Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
ADAM33	80332	broad.mit.edu	37	20	3651739	3651739	+	Silent	SNP	G	G	A			TCGA-97-7941-01A-11D-2184-08	TCGA-97-7941-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61181eca-24b7-4256-bf0b-7902359e4f4b	eb7be5ed-361f-463a-aa9d-6408387ded3a	g.chr20:3651739G>A	ENST00000356518.2	-	19	2395	c.2154C>T	c.(2152-2154)gcC>gcT	p.A718A	ADAM33_ENST00000466620.1_5'UTR|ADAM33_ENST00000379861.4_Silent_p.A718A|ADAM33_ENST00000350009.2_Silent_p.A692A	NM_025220.2	NP_079496.1	Q9BZ11	ADA33_HUMAN	ADAM metallopeptidase domain 33	718					proteolysis	integral to membrane	metalloendopeptidase activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(17)|ovary(1)|skin(3)	29						AGGCCAGGCCGGCCCCTGGGA	0.677000													3	7					0	0	1	0	0
SCN1A	6323	broad.mit.edu	37	2	166900521	166900521	+	Silent	SNP	C	C	T			TCGA-97-7941-01A-11D-2184-08	TCGA-97-7941-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61181eca-24b7-4256-bf0b-7902359e4f4b	eb7be5ed-361f-463a-aa9d-6408387ded3a	g.chr2:166900521C>T	ENST00000423058.2	-	11	1718	c.1701G>A	c.(1699-1701)agG>agA	p.R567R	AC010127.3_ENST00000595647.1_RNA|SCN1A_ENST00000409050.1_Silent_p.R567R|SCN1A_ENST00000375405.3_Silent_p.R567R|SCN1A_ENST00000303395.4_Silent_p.R567R|AC010127.3_ENST00000595268.1_RNA|AC010127.3_ENST00000599041.1_RNA	NM_001165963.1|NM_001202435.1	NP_001159435.1|NP_001189364.1	P35498	SCN1A_HUMAN	sodium channel, voltage-gated, type I, alpha subunit	567						voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(4)|breast(5)|endometrium(16)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(33)|lung(87)|ovary(7)|pancreas(1)|prostate(9)|skin(23)|upper_aerodigestive_tract(2)|urinary_tract(1)	200					Lamotrigine(DB00555)|Levetiracetam(DB01202)|Phenacemide(DB01121)|Phenytoin(DB00252)|Topiramate(DB00273)|Zonisamide(DB00909)	TGCTATTTCGCCTTGGTGAAA	0.418000													12	48					0	0	1	0	0
SPEF2	79925	broad.mit.edu	37	5	35793372	35793372	+	Missense_Mutation	SNP	G	G	C			TCGA-97-7941-01A-11D-2184-08	TCGA-97-7941-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61181eca-24b7-4256-bf0b-7902359e4f4b	eb7be5ed-361f-463a-aa9d-6408387ded3a	g.chr5:35793372G>C	ENST00000440995.2	+	32	4651	c.4651G>C	c.(4651-4653)Gag>Cag	p.E1551Q	CTD-2113L7.1_ENST00000510433.1_RNA|SPEF2_ENST00000356031.3_Missense_Mutation_p.E1556Q|SPEF2_ENST00000303129.4_Missense_Mutation_p.E353Q			Q9C093	SPEF2_HUMAN	sperm flagellar 2	1556					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		ATP binding|nucleobase, nucleoside, nucleotide kinase activity|protein dimerization activity			breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(15)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	37	all_lung(31;7.56e-05)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			GGAGCTCCTTGAGACCCTTCA	0.483000													13	77					0	0	1	0	0
GRM1	2911	broad.mit.edu	37	6	146351216	146351216	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7941-01A-11D-2184-08	TCGA-97-7941-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61181eca-24b7-4256-bf0b-7902359e4f4b	eb7be5ed-361f-463a-aa9d-6408387ded3a	g.chr6:146351216C>A	ENST00000392299.2	+	2	1033	c.563C>A	c.(562-564)aCa>aAa	p.T188K	GRM1_ENST00000355289.4_Missense_Mutation_p.T188K|GRM1_ENST00000507907.1_Missense_Mutation_p.T188K|GRM1_ENST00000492807.2_Missense_Mutation_p.T188K|GRM1_ENST00000361719.2_Missense_Mutation_p.T188K|GRM1_ENST00000282753.1_Missense_Mutation_p.T188K			Q13255	GRM1_HUMAN	glutamate receptor, metabotropic 1	188					synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			NS(2)|breast(5)|central_nervous_system(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(54)|ovary(7)|pancreas(2)|prostate(5)|skin(7)|upper_aerodigestive_tract(4)|urinary_tract(1)	126		Ovarian(120;0.0387)		OV - Ovarian serous cystadenocarcinoma(155;5.35e-08)|GBM - Glioblastoma multiforme(68;0.00762)	Acamprosate(DB00659)|L-Glutamic Acid(DB00142)	TATTCAGCCACAAGCATCGAC	0.522000													6	124					0.00307968	0.00324424	1	1	0
CACNA1F	778	broad.mit.edu	37	X	49066186	49066186	+	Missense_Mutation	SNP	G	G	A			TCGA-97-7941-01A-11D-2184-08	TCGA-97-7941-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61181eca-24b7-4256-bf0b-7902359e4f4b	eb7be5ed-361f-463a-aa9d-6408387ded3a	g.chrX:49066186G>A	ENST00000376265.2	-	41	4818	c.4757C>T	c.(4756-4758)aCa>aTa	p.T1586I	CACNA1F_ENST00000323022.5_Missense_Mutation_p.T1575I|CACNA1F_ENST00000376251.1_Missense_Mutation_p.T1521I	NM_005183.2	NP_005174.2	O60840	CAC1F_HUMAN	calcium channel, voltage-dependent, L type, alpha 1F subunit	1586					axon guidance|detection of light stimulus involved in visual perception	voltage-gated calcium channel complex	protein binding|voltage-gated calcium channel activity			autonomic_ganglia(1)|breast(8)|central_nervous_system(3)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(17)|lung(24)|ovary(5)|prostate(3)|skin(4)|urinary_tract(1)	85					Verapamil(DB00661)	GATCAGAAATGTGGCGTAGAA	0.592000													6	31					0	0	1	0	0
KIAA1045	23349	broad.mit.edu	37	9	34976631	34976631	+	Missense_Mutation	SNP	C	C	T			TCGA-97-7941-01A-11D-2184-08	TCGA-97-7941-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61181eca-24b7-4256-bf0b-7902359e4f4b	eb7be5ed-361f-463a-aa9d-6408387ded3a	g.chr9:34976631C>T	ENST00000242315.3	+	5	825	c.743C>T	c.(742-744)gCg>gTg	p.A248V	KIAA1045_ENST00000476115.2_3'UTR|KIAA1045_ENST00000544237.1_Missense_Mutation_p.A248V	NM_015297.1	NP_056112.1	Q9UPV7	K1045_HUMAN	KIAA1045	248							calcium ion binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(4)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	19			LUSC - Lung squamous cell carcinoma(32;0.00575)			GAAGAGCAGGCGGCCCGCCAG	0.612000													4	69					0	0	1	0	0
ADAM21P1	145241	broad.mit.edu	37	14	70713834	70713834	+	RNA	SNP	G	G	A			TCGA-97-7941-01A-11D-2184-08	TCGA-97-7941-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61181eca-24b7-4256-bf0b-7902359e4f4b	eb7be5ed-361f-463a-aa9d-6408387ded3a	g.chr14:70713834G>A	ENST00000530196.1	-	0	684					NR_003951.1																						AACTGTTGGCGTGCTACTTCC	0.453000													6	60					0	0	1	0	0
SPEN	23013	broad.mit.edu	37	1	16258564	16258564	+	Silent	SNP	G	G	A			TCGA-97-7941-01A-11D-2184-08	TCGA-97-7941-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61181eca-24b7-4256-bf0b-7902359e4f4b	eb7be5ed-361f-463a-aa9d-6408387ded3a	g.chr1:16258564G>A	ENST00000375759.3	+	11	6033	c.5829G>A	c.(5827-5829)gcG>gcA	p.A1943A		NM_015001.2	NP_055816.2	Q96T58	MINT_HUMAN	spen family transcriptional repressor	1943					interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|Notch signaling pathway	nucleus	nucleotide binding|protein binding|RNA binding			NS(1)|breast(13)|central_nervous_system(3)|cervix(5)|endometrium(16)|kidney(18)|large_intestine(27)|liver(2)|lung(37)|ovary(7)|prostate(7)|skin(7)|upper_aerodigestive_tract(5)|urinary_tract(1)	149		Colorectal(325;0.000258)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0185)|Colorectal(212;5.96e-07)|COAD - Colon adenocarcinoma(227;3.11e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000115)|Kidney(64;0.000212)|KIRC - Kidney renal clear cell carcinoma(64;0.003)|STAD - Stomach adenocarcinoma(313;0.013)|READ - Rectum adenocarcinoma(331;0.0681)		AGGCTGCAGCGGTTCCCACCA	0.587000													10	57					0	0	1	0	0
SCML2	10389	broad.mit.edu	37	X	18275064	18275064	+	Missense_Mutation	SNP	G	G	A			TCGA-97-7941-01A-11D-2184-08	TCGA-97-7941-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61181eca-24b7-4256-bf0b-7902359e4f4b	eb7be5ed-361f-463a-aa9d-6408387ded3a	g.chrX:18275064G>A	ENST00000251900.4	-	11	1519	c.1360C>T	c.(1360-1362)Cac>Tac	p.H454Y	SCML2_ENST00000398048.3_Missense_Mutation_p.H190Y	NM_006089.2	NP_006080.1	Q9UQR0	SCML2_HUMAN	sex comb on midleg-like 2 (Drosophila)	454					anatomical structure morphogenesis	PcG protein complex	DNA binding|sequence-specific DNA binding transcription factor activity			breast(4)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(13)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	36	Hepatocellular(33;0.183)					TGCAGACTGTGGCAGAAGTTC	0.468000													9	154					0	0	1	0	0
TEX264	51368	broad.mit.edu	37	3	51718507	51718507	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7941-01A-11D-2184-08	TCGA-97-7941-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61181eca-24b7-4256-bf0b-7902359e4f4b	eb7be5ed-361f-463a-aa9d-6408387ded3a	g.chr3:51718507G>T	ENST00000415259.1	+	3	1418	c.337G>T	c.(337-339)Gac>Tac	p.D113Y	TEX264_ENST00000395057.1_Missense_Mutation_p.D113Y|TEX264_ENST00000341333.5_Missense_Mutation_p.D113Y|TEX264_ENST00000416589.1_Missense_Mutation_p.D113Y|TEX264_ENST00000457573.1_Missense_Mutation_p.D113Y|TEX264_ENST00000463857.1_3'UTR			Q9Y6I9	TX264_HUMAN	testis expressed 264	113						extracellular region				NS(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(2)	7				BRCA - Breast invasive adenocarcinoma(193;8.53e-05)|Kidney(197;0.000594)|KIRC - Kidney renal clear cell carcinoma(197;0.000759)		TGAGCTCATCGACCTCTACCA	0.582000													11	47					7.03913e-09	9.43106e-09	1	1	0
ZNF510	22869	broad.mit.edu	37	9	99521573	99521573	+	Missense_Mutation	SNP	C	C	G			TCGA-97-7941-01A-11D-2184-08	TCGA-97-7941-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61181eca-24b7-4256-bf0b-7902359e4f4b	eb7be5ed-361f-463a-aa9d-6408387ded3a	g.chr9:99521573C>G	ENST00000375231.1	-	6	2189	c.1539G>C	c.(1537-1539)gaG>gaC	p.E513D	ZNF510_ENST00000223428.4_Missense_Mutation_p.E513D			Q9Y2H8	ZN510_HUMAN	zinc finger protein 510	513					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|endometrium(1)|kidney(3)|large_intestine(5)|lung(8)|stomach(1)|urinary_tract(1)	21		Acute lymphoblastic leukemia(62;0.0527)				GAAAGGATTTCTCCCCTGTGT	0.408000													5	239					0	0	1	0	0
KATNA1	11104	broad.mit.edu	37	6	149944338	149944338	+	Silent	SNP	G	G	A			TCGA-97-7941-01A-11D-2184-08	TCGA-97-7941-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61181eca-24b7-4256-bf0b-7902359e4f4b	eb7be5ed-361f-463a-aa9d-6408387ded3a	g.chr6:149944338G>A	ENST00000367411.2	-	4	660	c.402C>T	c.(400-402)gtC>gtT	p.V134V	KATNA1_ENST00000335643.8_Silent_p.V134V|KATNA1_ENST00000335647.5_Silent_p.V134V	NM_007044.3	NP_008975.1	O75449	KTNA1_HUMAN	katanin p60 (ATPase containing) subunit A 1	134	Interaction with microtubule.				cell division|interphase of mitotic cell cycle|mitosis	microtubule|microtubule organizing center|spindle pole	ATP binding|microtubule binding|microtubule-severing ATPase activity|protein heterodimerization activity			endometrium(1)|kidney(1)|large_intestine(2)|lung(5)|ovary(1)|skin(1)|urinary_tract(1)	12		Ovarian(120;0.0164)		OV - Ovarian serous cystadenocarcinoma(155;2.95e-12)|GBM - Glioblastoma multiforme(68;0.173)		GGTGAACTCTGACAGTTGTAC	0.423000													6	83					0	0	1	0	0
AFF4	27125	broad.mit.edu	37	5	132232334	132232334	+	Missense_Mutation	SNP	G	G	A			TCGA-97-7941-01A-11D-2184-08	TCGA-97-7941-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61181eca-24b7-4256-bf0b-7902359e4f4b	eb7be5ed-361f-463a-aa9d-6408387ded3a	g.chr5:132232334G>A	ENST00000265343.5	-	11	2367	c.1988C>T	c.(1987-1989)tCa>tTa	p.S663L	AFF4_ENST00000378595.3_Missense_Mutation_p.S663L	NM_014423.3	NP_055238.1	Q9UHB7	AFF4_HUMAN	AF4/FMR2 family, member 4	663					transcription from RNA polymerase II promoter	mitochondrion|nucleolus	protein binding|sequence-specific DNA binding transcription factor activity		SEPT8/AFF4(2)	breast(2)|central_nervous_system(2)|endometrium(6)|kidney(6)|large_intestine(7)|lung(11)|ovary(3)|pancreas(1)|prostate(3)|skin(2)	43		all_cancers(142;0.145)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			AGGAGTTTGTGAGGAAGGAGG	0.428000													17	66					0	0	1	0	0
PCDHB13	56123	broad.mit.edu	37	5	140594640	140594640	+	Silent	SNP	C	C	A			TCGA-97-7941-01A-11D-2184-08	TCGA-97-7941-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61181eca-24b7-4256-bf0b-7902359e4f4b	eb7be5ed-361f-463a-aa9d-6408387ded3a	g.chr5:140594640C>A	ENST00000341948.4	+	1	1132	c.945C>A	c.(943-945)tcC>tcA	p.S315S		NM_018933.2	NP_061756.1	Q9Y5F0	PCDBD_HUMAN		315	Cadherin 3.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			NS(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(14)|liver(4)|lung(24)|ovary(5)|pancreas(1)|skin(4)|upper_aerodigestive_tract(1)	66			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			AACTTCAGTCCTATGAAGTCA	0.388000													9	100					2.61681e-11	3.76167e-11	1	1	0
SLC6A10P	386757	broad.mit.edu	37	16	32890622	32890622	+	RNA	SNP	T	T	G			TCGA-97-7941-01A-11D-2184-08	TCGA-97-7941-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61181eca-24b7-4256-bf0b-7902359e4f4b	eb7be5ed-361f-463a-aa9d-6408387ded3a	g.chr16:32890622T>G	ENST00000330048.5	-	0	3176					NR_003083.2																						CGTTGGTGTTTTTGTAGACCA	0.617000													3	32					0	0	1	0	0
ANTXR1	84168	broad.mit.edu	37	2	69330019	69330019	+	Missense_Mutation	SNP	G	G	A			TCGA-97-7941-01A-11D-2184-08	TCGA-97-7941-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61181eca-24b7-4256-bf0b-7902359e4f4b	eb7be5ed-361f-463a-aa9d-6408387ded3a	g.chr2:69330019G>A	ENST00000303714.4	+	10	1071	c.749G>A	c.(748-750)cGc>cAc	p.R250H	ANTXR1_ENST00000409349.3_Missense_Mutation_p.R250H|ANTXR1_ENST00000409829.3_Missense_Mutation_p.R250H	NM_032208.2	NP_115584.1	Q9H6X2	ANTR1_HUMAN	anthrax toxin receptor 1	250					actin cytoskeleton reorganization|substrate adhesion-dependent cell spreading	filopodium membrane|integral to membrane|lamellipodium membrane	actin filament binding|collagen binding|metal ion binding|protein binding|transmembrane receptor activity			haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(16)|ovary(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	29						CGACATGCCCGCAACGTGGAC	0.478000									Familial Infantile Hemangioma				6	239					0	0	1	0	0
TIMM44	10469	broad.mit.edu	37	19	8002966	8002966	+	Silent	SNP	G	G	A			TCGA-97-7941-01A-11D-2184-08	TCGA-97-7941-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61181eca-24b7-4256-bf0b-7902359e4f4b	eb7be5ed-361f-463a-aa9d-6408387ded3a	g.chr19:8002966G>A	ENST00000270538.3	-	3	526	c.258C>T	c.(256-258)gaC>gaT	p.D86D		NM_006351.3	NP_006342.2	O43615	TIM44_HUMAN	translocase of inner mitochondrial membrane 44 homolog (yeast)	86					protein targeting to mitochondrion	mitochondrial inner membrane presequence translocase complex|mitochondrial matrix	ATP binding|P-P-bond-hydrolysis-driven protein transmembrane transporter activity			NS(1)|endometrium(3)|kidney(3)|large_intestine(2)|liver(2)|lung(2)|ovary(2)|skin(1)|urinary_tract(1)	17						TTCTGGCCTCGTCACGGAATT	0.428000													7	174					0	0	1	0	0
VN1R1	57191	broad.mit.edu	37	19	57967782	57967782	+	Missense_Mutation	SNP	C	C	T			TCGA-97-7941-01A-11D-2184-08	TCGA-97-7941-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61181eca-24b7-4256-bf0b-7902359e4f4b	eb7be5ed-361f-463a-aa9d-6408387ded3a	g.chr19:57967782C>T	ENST00000321039.3	-	1	72	c.73G>A	c.(73-75)Gat>Aat	p.D25N	AC004076.9_ENST00000596831.1_Intron|AC004076.9_ENST00000415705.3_Intron	NM_020633.3	NP_065684.1	Q9GZP7	VN1R1_HUMAN	vomeronasal 1 receptor 1	25					response to pheromone	integral to membrane|plasma membrane	pheromone receptor activity			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(8)|ovary(1)|pancreas(1)|skin(2)	19		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0694)|Renal(1328;0.157)|Breast(46;0.222)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0254)|Lung(386;0.171)		TCTGAAGAATCAGTAGAATAA	0.343000													4	38					0	0	1	0	0
IGHV3-7	28452	broad.mit.edu	37	14	106518634	106518634	+	RNA	SNP	G	G	C			TCGA-97-7941-01A-11D-2184-08	TCGA-97-7941-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61181eca-24b7-4256-bf0b-7902359e4f4b	eb7be5ed-361f-463a-aa9d-6408387ded3a	g.chr14:106518634G>C	ENST00000390598.2	-	0	195																											CTGCACAGGAGAGTCTCAGGG	0.582000													23	152					0	0	1	0	0
OR8D4	338662	broad.mit.edu	37	11	123777516	123777516	+	Silent	SNP	C	C	A			TCGA-97-7941-01A-11D-2184-08	TCGA-97-7941-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61181eca-24b7-4256-bf0b-7902359e4f4b	eb7be5ed-361f-463a-aa9d-6408387ded3a	g.chr11:123777516C>A	ENST00000321355.2	+	1	408	c.378C>A	c.(376-378)atC>atA	p.I126I		NM_001005197.1	NP_001005197.1	Q8NGM9	OR8D4_HUMAN	olfactory receptor, family 8, subfamily D, member 4	126					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(1)|lung(16)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	25		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.93e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0409)		ACGTGGCCATCTGCAGCCCAC	0.502000													17	69					3.41278e-10	4.80576e-10	1	1	0
FAM86A	196483	broad.mit.edu	37	16	5140288	5140288	+	Missense_Mutation	SNP	C	C	T	rs144582297	byFrequency	TCGA-97-7941-01A-11D-2184-08	TCGA-97-7941-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61181eca-24b7-4256-bf0b-7902359e4f4b	eb7be5ed-361f-463a-aa9d-6408387ded3a	g.chr16:5140288C>T	ENST00000427587.4	-	6	607	c.539G>A	c.(538-540)cGc>cAc	p.R180H	FAM86A_ENST00000458008.4_Missense_Mutation_p.R146H|FAM86A_ENST00000587133.1_Missense_Mutation_p.R119H	NM_201400.2	NP_958802.1	Q96G04	FA86A_HUMAN	family with sequence similarity 86, member A	180										endometrium(1)|large_intestine(2)|lung(4)|prostate(3)|skin(2)	12						TGCCCGGGGGCGGCACATCTT	0.607000													12	51					0	0	1	0	0
KHDC3L	154288	broad.mit.edu	37	6	74073285	74073285	+	Missense_Mutation	SNP	G	G	C			TCGA-97-7941-01A-11D-2184-08	TCGA-97-7941-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61181eca-24b7-4256-bf0b-7902359e4f4b	eb7be5ed-361f-463a-aa9d-6408387ded3a	g.chr6:74073285G>C	ENST00000370367.3	+	3	409	c.356G>C	c.(355-357)gGa>gCa	p.G119A		NM_001017361.2	NP_001017361.1			KH domain containing 3-like, subcortical maternal complex member																		CCAGGCTCAGGAAAGGCCCTC	0.617000													8	58					0	0	1	0	0
MYOCD	93649	broad.mit.edu	37	17	12620700	12620700	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7941-01A-11D-2184-08	TCGA-97-7941-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61181eca-24b7-4256-bf0b-7902359e4f4b	eb7be5ed-361f-463a-aa9d-6408387ded3a	g.chr17:12620700G>T	ENST00000425538.1	+	4	415	c.215G>T	c.(214-216)tGc>tTc	p.C72F	RP11-746E8.1_ENST00000578952.1_lincRNA|MYOCD_ENST00000343344.4_Missense_Mutation_p.C72F	NM_001146312.1|NM_153604.2	NP_001139784.1|NP_705832.1	Q8IZQ8	MYCD_HUMAN	myocardin	72					cardiac muscle cell differentiation|negative regulation of cell proliferation|negative regulation of cyclin-dependent protein kinase activity|positive regulation of smooth muscle cell differentiation|positive regulation of smooth muscle contraction|positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation|regulation of histone acetylation|smooth muscle cell differentiation	nucleus	nucleic acid binding|RNA polymerase II transcription factor binding transcription factor activity|transcription factor binding			breast(2)|central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(11)|liver(2)|lung(33)|ovary(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	70				UCEC - Uterine corpus endometrioid carcinoma (92;0.0969)		AGAAACAGGTGCAACAGTGCC	0.428000													6	29					3.09899e-07	3.92349e-07	1	1	0
OR2D2	120776	broad.mit.edu	37	11	6913156	6913156	+	Silent	SNP	G	G	T			TCGA-97-7941-01A-11D-2184-08	TCGA-97-7941-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61181eca-24b7-4256-bf0b-7902359e4f4b	eb7be5ed-361f-463a-aa9d-6408387ded3a	g.chr11:6913156G>T	ENST00000299459.2	-	1	674	c.576C>A	c.(574-576)acC>acA	p.T192T		NM_003700.1	NP_003691.1	Q9H210	OR2D2_HUMAN	olfactory receptor, family 2, subfamily D, member 2	192					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|cervix(1)|large_intestine(3)|lung(9)|ovary(1)|skin(2)	18		Medulloblastoma(188;0.0523)|all_neural(188;0.236)		Epithelial(150;4.68e-08)|BRCA - Breast invasive adenocarcinoma(625;0.129)		CTGATGCATGGGTGTCTGTGG	0.463000													3	42					0.150653	0.151753	1	1	0
TAOK2	9344	broad.mit.edu	37	16	29994190	29994190	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7941-01A-11D-2184-08	TCGA-97-7941-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61181eca-24b7-4256-bf0b-7902359e4f4b	eb7be5ed-361f-463a-aa9d-6408387ded3a	g.chr16:29994190G>T	ENST00000308893.4	+	11	2010	c.967G>T	c.(967-969)Ggc>Tgc	p.G323C	TAOK2_ENST00000279394.3_Missense_Mutation_p.G323C|TAOK2_ENST00000543033.1_Missense_Mutation_p.G323C|TAOK2_ENST00000416441.2_Missense_Mutation_p.G150C	NM_001252043.1|NM_016151.3	NP_001238972.1|NP_057235.2	Q9UL54	TAOK2_HUMAN	TAO kinase 2	323					actin cytoskeleton organization|activation of MAPKK activity|apoptosis|cell migration|focal adhesion assembly|positive regulation of JNK cascade|protein targeting to membrane|regulation of cell growth|regulation of cell shape|response to stress	cytoplasmic vesicle membrane|cytoskeleton|dendrite|integral to membrane|nucleolus	ATP binding|protein serine/threonine kinase activity			breast(1)|endometrium(3)|large_intestine(5)|lung(8)|ovary(1)|prostate(3)|skin(1)	22						GGCACCCAACGGCCCTGGTGC	0.602000													15	69					8.34094e-07	1.02772e-06	1	1	0
RPL19	6143	broad.mit.edu	37	17	37360818	37360818	+	Missense_Mutation	SNP	C	C	G			TCGA-97-7941-01A-11D-2184-08	TCGA-97-7941-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61181eca-24b7-4256-bf0b-7902359e4f4b	eb7be5ed-361f-463a-aa9d-6408387ded3a	g.chr17:37360818C>G	ENST00000579260.1	+	6	905	c.502C>G	c.(502-504)Cgc>Ggc	p.R168G	RPL19_ENST00000579374.1_Missense_Mutation_p.R167G|RPL19_ENST00000582193.1_Missense_Mutation_p.R168G|RPL19_ENST00000225430.4_Missense_Mutation_p.R170G			P84098	RL19_HUMAN	ribosomal protein L19	170					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit	RNA binding|structural constituent of ribosome			kidney(1)|large_intestine(1)|lung(3)|prostate(1)|upper_aerodigestive_tract(1)	7						CAAGGAAGCACGCAAGCGCCG	0.527000													3	68					0	0	1	0	0
RPS6KA6	27330	broad.mit.edu	37	X	83372087	83372087	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7941-01A-11D-2184-08	TCGA-97-7941-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61181eca-24b7-4256-bf0b-7902359e4f4b	eb7be5ed-361f-463a-aa9d-6408387ded3a	g.chrX:83372087C>A	ENST00000262752.2	-	11	937	c.930G>T	c.(928-930)agG>agT	p.R310S	RPS6KA6_ENST00000543399.1_Missense_Mutation_p.R310S	NM_014496.4	NP_055311.1	Q9UK32	KS6A6_HUMAN	ribosomal protein S6 kinase, 90kDa, polypeptide 6	310	Protein kinase 1.				axon guidance|central nervous system development|intracellular protein kinase cascade|synaptic transmission	cytosol|nucleoplasm	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			NS(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(26)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	46						TTGCTGGATTCCTTTTGAATA	0.323000													13	34					1.3612e-06	1.66235e-06	1	1	0
TEP1	7011	broad.mit.edu	37	14	20876303	20876303	+	Missense_Mutation	SNP	G	G	C			TCGA-97-7941-01A-11D-2184-08	TCGA-97-7941-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61181eca-24b7-4256-bf0b-7902359e4f4b	eb7be5ed-361f-463a-aa9d-6408387ded3a	g.chr14:20876303G>C	ENST00000262715.5	-	2	336	c.296C>G	c.(295-297)tCt>tGt	p.S99C	TEP1_ENST00000556935.1_Missense_Mutation_p.S99C	NM_007110.4	NP_009041.2	Q99973	TEP1_HUMAN	telomerase-associated protein 1	99					telomere maintenance via recombination	chromosome, telomeric region|cytoplasm|nuclear matrix|soluble fraction|telomerase holoenzyme complex	ATP binding|RNA binding			NS(4)|breast(1)|central_nervous_system(4)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(48)|ovary(7)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	96	all_cancers(95;0.00123)	all_lung(585;0.235)	Epithelial(56;7.42e-08)|all cancers(55;6.46e-07)	GBM - Glioblastoma multiforme(265;0.028)|READ - Rectum adenocarcinoma(17;0.233)		TGGGTGGGCAGAAACATGTCC	0.552000													5	122					0	0	1	0	0
FN1	2335	broad.mit.edu	37	2	216296671	216296671	+	Silent	SNP	C	C	A			TCGA-97-7941-01A-11D-2184-08	TCGA-97-7941-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61181eca-24b7-4256-bf0b-7902359e4f4b	eb7be5ed-361f-463a-aa9d-6408387ded3a	g.chr2:216296671C>A	ENST00000354785.4	-	4	801	c.432G>T	c.(430-432)ggG>ggT	p.G144G	FN1_ENST00000359671.1_Silent_p.G144G|FN1_ENST00000357867.4_Silent_p.G144G|FN1_ENST00000357009.2_Silent_p.G144G|FN1_ENST00000356005.4_Silent_p.G144G|FN1_ENST00000346544.3_Silent_p.G144G|FN1_ENST00000345488.5_Silent_p.G144G|FN1_ENST00000336916.4_Silent_p.G144G|FN1_ENST00000323926.6_Silent_p.G144G|FN1_ENST00000426059.1_Silent_p.G144G|FN1_ENST00000446046.1_Silent_p.G144G|FN1_ENST00000443816.1_Silent_p.G144G|FN1_ENST00000432072.2_Silent_p.G144G|FN1_ENST00000421182.1_Silent_p.G144G			P02751	FINC_HUMAN	fibronectin 1	144	Fibrin- and heparin-binding 1.|Fibronectin type-I 3.				acute-phase response|angiogenesis|leukocyte migration|peptide cross-linking|platelet activation|platelet degranulation|regulation of cell shape|substrate adhesion-dependent cell spreading	ER-Golgi intermediate compartment|fibrinogen complex|platelet alpha granule lumen|proteinaceous extracellular matrix	collagen binding|extracellular matrix structural constituent|heparin binding		FN1/ALK(2)	NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(7)|endometrium(9)|kidney(8)|large_intestine(33)|lung(38)|ovary(1)|pancreas(1)|prostate(3)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)	109		Renal(323;0.127)		Epithelial(149;9.59e-07)|all cancers(144;0.000174)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)	Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	AGGACTGACCCCCTTCATGGC	0.448000													19	86					1.50039e-11	2.17951e-11	1	1	0
SEMA3C	10512	broad.mit.edu	37	7	80374432	80374432	+	Silent	SNP	G	G	A			TCGA-97-7941-01A-11D-2184-08	TCGA-97-7941-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61181eca-24b7-4256-bf0b-7902359e4f4b	eb7be5ed-361f-463a-aa9d-6408387ded3a	g.chr7:80374432G>A	ENST00000265361.3	-	18	2595	c.2034C>T	c.(2032-2034)acC>acT	p.T678T	SEMA3C_ENST00000544525.1_Silent_p.T696T|SEMA3C_ENST00000419255.2_Silent_p.T678T	NM_006379.3	NP_006370.1	Q99985	SEM3C_HUMAN	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C	678					immune response|response to drug	membrane	receptor activity			NS(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(17)|ovary(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	34						AGCTGGCCCAGGTCCATGGGG	0.463000													16	63					0	0	1	0	0
APOB	338	broad.mit.edu	37	2	21234989	21234989	+	Missense_Mutation	SNP	G	G	C			TCGA-97-7941-01A-11D-2184-08	TCGA-97-7941-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61181eca-24b7-4256-bf0b-7902359e4f4b	eb7be5ed-361f-463a-aa9d-6408387ded3a	g.chr2:21234989G>C	ENST00000233242.1	-	26	4878	c.4751C>G	c.(4750-4752)tCt>tGt	p.S1584C		NM_000384.2	NP_000375.2	P04114	APOB_HUMAN	apolipoprotein B	1584					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			NS(5)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(19)|kidney(10)|large_intestine(63)|liver(5)|lung(125)|ovary(16)|pancreas(1)|prostate(5)|skin(31)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(6)	305	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	CATCTTGTTAGAAGTGGCAAA	0.403000													3	51					0	0	1	0	0
RNF213	57674	broad.mit.edu	37	17	78319618	78319618	+	Missense_Mutation	SNP	A	A	G			TCGA-97-7941-01A-11D-2184-08	TCGA-97-7941-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61181eca-24b7-4256-bf0b-7902359e4f4b	eb7be5ed-361f-463a-aa9d-6408387ded3a	g.chr17:78319618A>G	ENST00000582970.1	+	29	7626	c.7483A>G	c.(7483-7485)Ata>Gta	p.I2495V	RNF213_ENST00000336301.6_Missense_Mutation_p.I568V|RNF213_ENST00000508628.2_Missense_Mutation_p.I2544V	NM_001256071.1	NP_001243000.1	Q9HCF4	ALO17_HUMAN	ring finger protein 213	0								p.I568L(1)		NS(1)|breast(7)|central_nervous_system(1)|cervix(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(23)|lung(36)|ovary(11)|pancreas(2)|prostate(4)|skin(3)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	130	all_neural(118;0.0538)		BRCA - Breast invasive adenocarcinoma(99;0.0252)|OV - Ovarian serous cystadenocarcinoma(97;0.057)			AACGGAAGCTATAAGCTGTAT	0.488000													16	84					0	0	1	0	0
ASIC3	9311	broad.mit.edu	37	7	150746080	150746080	+	Silent	SNP	C	C	A			TCGA-97-7941-01A-11D-2184-08	TCGA-97-7941-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61181eca-24b7-4256-bf0b-7902359e4f4b	eb7be5ed-361f-463a-aa9d-6408387ded3a	g.chr7:150746080C>A	ENST00000357922.4	+	1	702	c.108C>A	c.(106-108)ggC>ggA	p.G36G	ASIC3_ENST00000297512.8_Silent_p.G36G|ASIC3_ENST00000349064.5_Silent_p.G36G	NM_020322.3	NP_064718.1	Q9UHC3	ACCN3_HUMAN	acid-sensing (proton-gated) ion channel 3	36					sensory perception|signal transduction	cytoplasm|integral to plasma membrane	ligand-gated sodium channel activity										TCGGGCCAGGCAGCCTGAGCC	0.697000													6	43					0.00116845	0.00124996	1	1	0
SRBD1	55133	broad.mit.edu	37	2	45774723	45774723	+	Silent	SNP	G	G	A			TCGA-97-7941-01A-11D-2184-08	TCGA-97-7941-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61181eca-24b7-4256-bf0b-7902359e4f4b	eb7be5ed-361f-463a-aa9d-6408387ded3a	g.chr2:45774723G>A	ENST00000263736.4	-	13	1766	c.1704C>T	c.(1702-1704)taC>taT	p.Y568Y	SRBD1_ENST00000535761.1_Silent_p.Y87Y	NM_018079.4	NP_060549.4	Q8N5C6	SRBD1_HUMAN	S1 RNA binding domain 1	568					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		hydrolase activity, acting on ester bonds|RNA binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(13)|large_intestine(8)|lung(15)|skin(2)|stomach(1)|urinary_tract(1)	49		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)	LUSC - Lung squamous cell carcinoma(58;0.0917)|Lung(47;0.154)			CACAATGCAAGTAAACCACAT	0.313000													7	33					0	0	1	0	0
PCDHB3	56132	broad.mit.edu	37	5	140480999	140480999	+	Missense_Mutation	SNP	C	C	T			TCGA-97-7941-01A-11D-2184-08	TCGA-97-7941-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61181eca-24b7-4256-bf0b-7902359e4f4b	eb7be5ed-361f-463a-aa9d-6408387ded3a	g.chr5:140480999C>T	ENST00000231130.2	+	1	766	c.766C>T	c.(766-768)Ccc>Tcc	p.P256S	AC005754.7_ENST00000607216.1_RNA	NM_018937.2	NP_061760.1	Q9Y5E6	PCDB3_HUMAN		256	Cadherin 3.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			NS(2)|breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(19)|lung(24)|ovary(1)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	72			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			AGAGAATACCCCCGTTAACTC	0.428000													9	99					0	0	1	0	0
DOCK11	139818	broad.mit.edu	37	X	117707926	117707926	+	Nonsense_Mutation	SNP	C	C	A			TCGA-97-7941-01A-11D-2184-08	TCGA-97-7941-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61181eca-24b7-4256-bf0b-7902359e4f4b	eb7be5ed-361f-463a-aa9d-6408387ded3a	g.chrX:117707926C>A	ENST00000276204.6	+	12	1408	c.1334C>A	c.(1333-1335)tCa>tAa	p.S445*	DOCK11_ENST00000276202.7_Nonsense_Mutation_p.S445*			Q5JSL3	DOC11_HUMAN	dedicator of cytokinesis 11	445					blood coagulation	cytosol	GTP binding			breast(4)|cervix(2)|endometrium(8)|kidney(5)|large_intestine(17)|liver(1)|lung(35)|ovary(4)|prostate(3)|skin(3)|stomach(1)|urinary_tract(1)	84						AAGGGCTCTTCACCCGAATCT	0.468000													19	67					9.57634e-11	1.36241e-10	1	1	0
ZNF730	100129543	broad.mit.edu	37	19	23328736	23328736	+	Nonsense_Mutation	SNP	C	C	G			TCGA-97-7941-01A-11D-2184-08	TCGA-97-7941-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61181eca-24b7-4256-bf0b-7902359e4f4b	eb7be5ed-361f-463a-aa9d-6408387ded3a	g.chr19:23328736C>G	ENST00000597761.2	+	4	1089	c.890C>G	c.(889-891)tCa>tGa	p.S297*		NM_001277403.1	NP_001264332.1			zinc finger protein 730											endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(7)|pancreas(1)|stomach(2)|urinary_tract(1)	16						AACCAGTCCTCAAACCTTACT	0.348000													3	33					0	0	1	0	0
SCN10A	6336	broad.mit.edu	37	3	38763897	38763897	+	Missense_Mutation	SNP	A	A	T			TCGA-97-7941-01A-11D-2184-08	TCGA-97-7941-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61181eca-24b7-4256-bf0b-7902359e4f4b	eb7be5ed-361f-463a-aa9d-6408387ded3a	g.chr3:38763897A>T	ENST00000449082.2	-	19	3358	c.3359T>A	c.(3358-3360)aTt>aAt	p.I1120N		NM_006514.2	NP_006505.2	Q9Y5Y9	SCNAA_HUMAN	sodium channel, voltage-gated, type X, alpha subunit	1120					sensory perception	voltage-gated sodium channel complex				NS(5)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(14)|kidney(5)|large_intestine(33)|lung(54)|ovary(5)|pancreas(1)|prostate(5)|skin(13)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	150				KIRC - Kidney renal clear cell carcinoma(284;0.0769)|Kidney(284;0.0945)	Benzocaine(DB01086)|Bupivacaine(DB00297)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dibucaine(DB00527)|Dyclonine(DB00645)|Hexylcaine(DB00473)|Levobupivacaine(DB01002)|Lidocaine(DB00281)|Mepivacaine(DB00961)|Oxybuprocaine(DB00892)|Procaine(DB00721)|Proparacaine(DB00807)|Ropivacaine(DB00296)	ACAGTGGCGAATGCATCCTGT	0.562000													29	177					0	0	1	0	0
BARHL1	56751	broad.mit.edu	37	9	135464783	135464783	+	Silent	SNP	G	G	T			TCGA-97-7941-01A-11D-2184-08	TCGA-97-7941-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61181eca-24b7-4256-bf0b-7902359e4f4b	eb7be5ed-361f-463a-aa9d-6408387ded3a	g.chr9:135464783G>T	ENST00000263610.2	+	3	1471	c.858G>T	c.(856-858)ccG>ccT	p.P286P	BARHL1_ENST00000542090.1_Silent_p.P286P	NM_020064.3	NP_064448.1	Q9BZE3	BARH1_HUMAN	BarH-like homeobox 1	286						nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			cervix(1)|large_intestine(2)|lung(2)|skin(3)	8				OV - Ovarian serous cystadenocarcinoma(145;1.79e-06)|Epithelial(140;3.12e-05)		CCAGCGCGCCGCCGCCTGCTC	0.721000													4	34					0.000602214	0.000654375	1	1	0
IFT88	8100	broad.mit.edu	37	13	21166516	21166516	+	Missense_Mutation	SNP	C	C	T			TCGA-97-7941-01A-11D-2184-08	TCGA-97-7941-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61181eca-24b7-4256-bf0b-7902359e4f4b	eb7be5ed-361f-463a-aa9d-6408387ded3a	g.chr13:21166516C>T	ENST00000382778.4	+	8	1516	c.398C>T	c.(397-399)tCc>tTc	p.S133F	IFT88_ENST00000351808.5_Missense_Mutation_p.S124F|IFT88_ENST00000319980.6_Missense_Mutation_p.S133F|IFT88_ENST00000537103.1_Missense_Mutation_p.S105F			Q13099	IFT88_HUMAN	intraflagellar transport 88 homolog (Chlamydomonas)	133					cilium morphogenesis	centriole|intraflagellar transport particle B|microtubule basal body|microtubule-based flagellum	protein binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(13)|ovary(1)|prostate(2)|skin(2)|urinary_tract(1)	27		all_cancers(29;5.79e-25)|all_epithelial(30;2.57e-20)|all_lung(29;3.13e-16)|Lung SC(185;0.0262)|Ovarian(182;0.0825)|Hepatocellular(188;0.244)		all cancers(112;0.000667)|Epithelial(112;0.00119)|OV - Ovarian serous cystadenocarcinoma(117;0.0141)|Lung(94;0.0183)|LUSC - Lung squamous cell carcinoma(192;0.0528)		GGCCCTGCTTCCCCTTTGGAA	0.358000													3	45					0	0	1	0	0
ABT1	29777	broad.mit.edu	37	6	26598733	26598733	+	Missense_Mutation	SNP	C	C	T			TCGA-97-7941-01A-11D-2184-08	TCGA-97-7941-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61181eca-24b7-4256-bf0b-7902359e4f4b	eb7be5ed-361f-463a-aa9d-6408387ded3a	g.chr6:26598733C>T	ENST00000274849.1	+	3	710	c.679C>T	c.(679-681)Cgg>Tgg	p.R227W		NM_013375.3	NP_037507.1	Q9ULW3	ABT1_HUMAN	activator of basal transcription 1	227					regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleolus	DNA binding|nucleotide binding|protein binding|RNA binding|transcription coactivator activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(3)|ovary(1)|urinary_tract(1)	11						TAAAGCAGCACGGCCAGGGGG	0.657000													12	65					0	0	1	0	0
SMAD4	4089	broad.mit.edu	37	18	48593406	48593406	+	Missense_Mutation	SNP	G	G	T	rs121912580		TCGA-97-7941-01A-11D-2184-08	TCGA-97-7941-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61181eca-24b7-4256-bf0b-7902359e4f4b	eb7be5ed-361f-463a-aa9d-6408387ded3a	g.chr18:48593406G>T	ENST00000342988.3	+	10	1695	c.1157G>T	c.(1156-1158)gGt>gTt	p.G386V	SMAD4_ENST00000398417.2_Missense_Mutation_p.G386V|SMAD4_ENST00000588745.1_Missense_Mutation_p.G290V	NM_005359.5	NP_005350.1	Q13485	SMAD4_HUMAN	SMAD family member 4	386	MH2.		G -> D (in JP/HHT; dbSNP:rs28936393).		BMP signaling pathway|negative regulation of cell growth|negative regulation of protein catabolic process|negative regulation of transcription, DNA-dependent|palate development|positive regulation of epithelial to mesenchymal transition|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of SMAD protein import into nucleus|positive regulation of transforming growth factor beta receptor signaling pathway|regulation of transforming growth factor-beta2 production|response to hypoxia|response to transforming growth factor beta stimulus|SMAD protein complex assembly|SMAD protein signal transduction|transforming growth factor beta receptor signaling pathway	activin responsive factor complex|centrosome|cytosol	I-SMAD binding|protein homodimerization activity|R-SMAD binding|transcription regulatory region DNA binding|transforming growth factor beta receptor, common-partner cytoplasmic mediator activity	p.0?(36)|p.?(2)		NS(2)|biliary_tract(19)|breast(9)|central_nervous_system(2)|endometrium(2)|gastrointestinal_tract_(site_indeterminate)(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(142)|liver(2)|lung(27)|oesophagus(4)|ovary(7)|pancreas(180)|prostate(3)|skin(1)|small_intestine(9)|stomach(5)|testis(2)|thyroid(19)|upper_aerodigestive_tract(10)|urinary_tract(2)|vulva(1)	454		all_cancers(7;0.203)|Colorectal(6;0.003)|all_epithelial(6;0.00336)		Colorectal(16;0.0032)|COAD - Colon adenocarcinoma(17;0.0708)|READ - Rectum adenocarcinoma(32;0.155)		ATAGGCAAAGGTGTGCAGTTG	0.368000													18	68					1.55469e-16	2.33204e-16	1	1	0
CDHR5	53841	broad.mit.edu	37	11	619514	619514	+	Missense_Mutation	SNP	G	G	A			TCGA-97-7941-01A-11D-2184-08	TCGA-97-7941-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61181eca-24b7-4256-bf0b-7902359e4f4b	eb7be5ed-361f-463a-aa9d-6408387ded3a	g.chr11:619514G>A	ENST00000358353.3	-	12	1575	c.1253C>T	c.(1252-1254)aCc>aTc	p.T418I	CDHR5_ENST00000397542.2_Missense_Mutation_p.T418I|CDHR5_ENST00000349570.7_Missense_Mutation_p.T418I			Q9HBB8	CDHR5_HUMAN	cadherin-related family member 5	418	Cadherin 4.				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(1)|endometrium(4)|kidney(1)|large_intestine(6)|lung(7)|ovary(1)|skin(2)	23						TGTGGTGGTGGTCAGCACAAC	0.597000													25	144					0	0	1	0	0
ZNF423	23090	broad.mit.edu	37	16	49669967	49669967	+	Silent	SNP	C	C	A	rs145829157		TCGA-97-7941-01A-11D-2184-08	TCGA-97-7941-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61181eca-24b7-4256-bf0b-7902359e4f4b	eb7be5ed-361f-463a-aa9d-6408387ded3a	g.chr16:49669967C>A	ENST00000561648.1	-	4	3149	c.3096G>T	c.(3094-3096)acG>acT	p.T1032T	ZNF423_ENST00000567169.1_Silent_p.T915T|ZNF423_ENST00000562520.1_Silent_p.T972T|ZNF423_ENST00000562871.1_Silent_p.T972T|ZNF423_ENST00000535559.1_Silent_p.T915T|ZNF423_ENST00000262383.2_Silent_p.T1032T|ZNF423_ENST00000563137.2_Silent_p.T972T	NM_001271620.1	NP_001258549.1	Q2M1K9	ZN423_HUMAN	zinc finger protein 423	1032					cell differentiation|negative regulation of transcription, DNA-dependent|nervous system development|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(8)|kidney(6)|large_intestine(16)|lung(47)|ovary(1)|pancreas(2)|prostate(4)|skin(1)|urinary_tract(2)	89		all_cancers(37;0.0155)				TGAGCTCAAGCGTGGAAGTGA	0.597000													4	35					4.096e-09	5.54165e-09	1	1	0
CDH4	1002	broad.mit.edu	37	20	60504878	60504878	+	Silent	SNP	C	C	T			TCGA-97-7941-01A-11D-2184-08	TCGA-97-7941-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61181eca-24b7-4256-bf0b-7902359e4f4b	eb7be5ed-361f-463a-aa9d-6408387ded3a	g.chr20:60504878C>T	ENST00000360469.5	+	13	2305	c.2217C>T	c.(2215-2217)ctC>ctT	p.L739L	CDH4_ENST00000543233.1_Silent_p.L665L	NM_001794.3	NP_001785.2	P55283	CADH4_HUMAN	cadherin 4, type 1, R-cadherin (retinal)	739					adherens junction organization|cell junction assembly		calcium ion binding			NS(2)|breast(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|liver(2)|lung(25)|ovary(2)|prostate(1)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	74			BRCA - Breast invasive adenocarcinoma(19;2.36e-08)			TGGCCATCCTCATCTGCATCC	0.622000													18	62					0	0	1	0	0
C10orf90	118611	broad.mit.edu	37	10	128153375	128153375	+	Missense_Mutation	SNP	C	C	G			TCGA-97-7941-01A-11D-2184-08	TCGA-97-7941-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61181eca-24b7-4256-bf0b-7902359e4f4b	eb7be5ed-361f-463a-aa9d-6408387ded3a	g.chr10:128153375C>G	ENST00000284694.7	-	4	1544	c.1424G>C	c.(1423-1425)aGc>aCc	p.S475T	C10orf90_ENST00000454341.1_Intron|C10orf90_ENST00000356858.3_Missense_Mutation_p.S428T|C10orf90_ENST00000544758.1_Missense_Mutation_p.S572T	NM_001004298.2	NP_001004298.2	Q96M02	CJ090_HUMAN	chromosome 10 open reading frame 90	475										NS(1)|breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(19)|liver(1)|lung(29)|ovary(2)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	65		all_epithelial(44;4.51e-05)|all_lung(145;0.0068)|Lung NSC(174;0.0105)|Colorectal(57;0.0848)|all_neural(114;0.0936)|Breast(234;0.203)		COAD - Colon adenocarcinoma(40;0.0442)|Colorectal(40;0.0479)		TTTCAGGAAGCTTTGATGTCG	0.473000													6	39					0	0	1	0	0
CACNA1B	774	broad.mit.edu	37	9	140953545	140953545	+	Silent	SNP	C	C	T			TCGA-97-7941-01A-11D-2184-08	TCGA-97-7941-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61181eca-24b7-4256-bf0b-7902359e4f4b	eb7be5ed-361f-463a-aa9d-6408387ded3a	g.chr9:140953545C>T	ENST00000277549.5	+	31	4645	c.2076C>T	c.(2074-2076)ccC>ccT	p.P692P	CACNA1B_ENST00000371363.1_Silent_p.P1496P|CACNA1B_ENST00000371357.1_Silent_p.P1497P|CACNA1B_ENST00000277551.2_Silent_p.P1496P|CACNA1B_ENST00000371372.1_Silent_p.P1496P|CACNA1B_ENST00000371355.4_Silent_p.P1497P			Q00975	CAC1B_HUMAN	calcium channel, voltage-dependent, N type, alpha 1B subunit	1496					membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	ATP binding|protein C-terminus binding|voltage-gated calcium channel activity			NS(3)|autonomic_ganglia(1)|breast(7)|central_nervous_system(1)|endometrium(10)|kidney(2)|large_intestine(17)|lung(31)|ovary(1)|prostate(1)|skin(2)|stomach(2)|urinary_tract(2)	80	all_cancers(76;0.166)			OV - Ovarian serous cystadenocarcinoma(145;1.16e-05)|Epithelial(140;0.000476)	Amlodipine(DB00381)|Gabapentin(DB00996)	ATGATGCACCCTATGAGTACG	0.542000													5	30					0	0	1	0	0
MOB1B	92597	broad.mit.edu	37	4	71824700	71824700	+	Missense_Mutation	SNP	C	C	T			TCGA-97-7941-01A-11D-2184-08	TCGA-97-7941-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61181eca-24b7-4256-bf0b-7902359e4f4b	eb7be5ed-361f-463a-aa9d-6408387ded3a	g.chr4:71824700C>T	ENST00000309395.2	+	2	325	c.124C>T	c.(124-126)Cgg>Tgg	p.R42W	MOB1B_ENST00000511449.1_3'UTR|MOB1B_ENST00000396051.2_Missense_Mutation_p.R47W	NM_001244766.1|NM_173468.3	NP_001231695.1|NP_775739.1	Q7L9L4	MOL1A_HUMAN	MOB kinase activator 1B	42					hippo signaling cascade|protein autophosphorylation	cytoplasm|nucleus	kinase activator activity|kinase binding|metal ion binding										TGGCAACCTTCGGATGGCTGT	0.433000													10	28					0	0	1	0	0
RELN	5649	broad.mit.edu	37	7	103138348	103138348	+	Missense_Mutation	SNP	C	C	T			TCGA-97-7941-01A-11D-2184-08	TCGA-97-7941-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61181eca-24b7-4256-bf0b-7902359e4f4b	eb7be5ed-361f-463a-aa9d-6408387ded3a	g.chr7:103138348C>T	ENST00000428762.1	-	55	9028	c.8869G>A	c.(8869-8871)Ggt>Agt	p.G2957S	CTB-107G13.1_ENST00000422488.1_RNA|RELN_ENST00000343529.5_Missense_Mutation_p.G2957S|RELN_ENST00000424685.2_Missense_Mutation_p.G2957S	NM_005045.3	NP_005036.2	P78509	RELN_HUMAN	reelin	2957					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			NS(3)|breast(8)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(43)|lung(101)|ovary(9)|pancreas(2)|prostate(4)|skin(14)|stomach(2)|upper_aerodigestive_tract(12)|urinary_tract(2)	227				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		TTCTCACTACCGATGCGCCCC	0.468000													5	69					0	0	1	0	0
PRRC1	133619	broad.mit.edu	37	5	126874745	126874745	+	Missense_Mutation	SNP	G	G	A			TCGA-97-7941-01A-11D-2184-08	TCGA-97-7941-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61181eca-24b7-4256-bf0b-7902359e4f4b	eb7be5ed-361f-463a-aa9d-6408387ded3a	g.chr5:126874745G>A	ENST00000442138.2	+	7	1081	c.935G>A	c.(934-936)cGg>cAg	p.R312Q	PRRC1_ENST00000512635.2_Missense_Mutation_p.R312Q|PRRC1_ENST00000296666.8_Missense_Mutation_p.R312Q			Q96M27	PRRC1_HUMAN	proline-rich coiled-coil 1	312						Golgi apparatus				endometrium(1)|large_intestine(1)|lung(4)	6		Prostate(80;0.165)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0851)|Epithelial(69;0.113)		GCTCAGGAACGGATAGATAGC	0.373000													6	83					0	0	1	0	0
CACNA2D3	55799	broad.mit.edu	37	3	54919551	54919551	+	Missense_Mutation	SNP	G	G	A			TCGA-97-7941-01A-11D-2184-08	TCGA-97-7941-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61181eca-24b7-4256-bf0b-7902359e4f4b	eb7be5ed-361f-463a-aa9d-6408387ded3a	g.chr3:54919551G>A	ENST00000474759.1	+	23	2042	c.1994G>A	c.(1993-1995)cGc>cAc	p.R665H	CACNA2D3_ENST00000288197.5_Missense_Mutation_p.R665H|CACNA2D3_ENST00000490478.1_Missense_Mutation_p.R571H|CACNA2D3-AS1_ENST00000471265.1_RNA|CACNA2D3_ENST00000415676.2_Missense_Mutation_p.R665H	NM_018398.2	NP_060868.2	Q8IZS8	CA2D3_HUMAN	calcium channel, voltage-dependent, alpha 2/delta subunit 3	665						integral to membrane	calcium channel activity|metal ion binding|voltage-gated ion channel activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(17)|ovary(1)|prostate(1)|skin(5)|stomach(1)|urinary_tract(3)	59				KIRC - Kidney renal clear cell carcinoma(284;0.00287)|Kidney(284;0.00327)		CCTGAGCACCGCCATCTGTCT	0.473000													7	25					0	0	1	0	0
GPR112	139378	broad.mit.edu	37	X	135430454	135430454	+	Missense_Mutation	SNP	A	A	G			TCGA-97-7941-01A-11D-2184-08	TCGA-97-7941-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61181eca-24b7-4256-bf0b-7902359e4f4b	eb7be5ed-361f-463a-aa9d-6408387ded3a	g.chrX:135430454A>G	ENST00000394143.1	+	6	4880	c.4589A>G	c.(4588-4590)gAc>gGc	p.D1530G	GPR112_ENST00000287534.4_Missense_Mutation_p.D1467G|GPR112_ENST00000412101.1_Missense_Mutation_p.D1325G|GPR112_ENST00000394141.1_Missense_Mutation_p.D1325G|GPR112_ENST00000370652.1_Missense_Mutation_p.D1530G	NM_153834.3	NP_722576.3	Q8IZF6	GP112_HUMAN	G protein-coupled receptor 112	1530					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(2)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(33)|lung(97)|ovary(5)|pancreas(2)|prostate(4)|skin(10)|upper_aerodigestive_tract(1)|urinary_tract(2)	199	Acute lymphoblastic leukemia(192;0.000127)					AAAGTTTCTGACACTCCCCCA	0.433000													3	102					0	0	1	0	0
HYAL3	8372	broad.mit.edu	37	3	50332964	50332964	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7941-01A-11D-2184-08	TCGA-97-7941-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61181eca-24b7-4256-bf0b-7902359e4f4b	eb7be5ed-361f-463a-aa9d-6408387ded3a	g.chr3:50332964G>T	ENST00000336307.1	-	2	342	c.70C>A	c.(70-72)Cca>Aca	p.P24T	HYAL3_ENST00000450982.1_Missense_Mutation_p.P24T|HYAL3_ENST00000359051.3_Missense_Mutation_p.P24T|HYAL3_ENST00000513170.1_Intron|HYAL3_ENST00000415204.1_Intron	NM_001200029.1|NM_003549.3	NP_001186958.1|NP_003540.2	O43820	HYAL3_HUMAN	hyaluronoglucosaminidase 3	24					carbohydrate metabolic process	extracellular region|lysosome	hyalurononglucosaminidase activity			central_nervous_system(1)|endometrium(2)|kidney(1)|lung(5)|ovary(3)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	19				BRCA - Breast invasive adenocarcinoma(193;0.000272)|KIRC - Kidney renal clear cell carcinoma(197;0.00544)|Kidney(197;0.00607)		GGGACCTGTGGTAGGGGCTGG	0.627000													9	40					0.000274275	0.0003028	1	1	0
SRBD1	55133	broad.mit.edu	37	2	45774718	45774718	+	Missense_Mutation	SNP	T	T	A	rs35369160		TCGA-97-7941-01A-11D-2184-08	TCGA-97-7941-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61181eca-24b7-4256-bf0b-7902359e4f4b	eb7be5ed-361f-463a-aa9d-6408387ded3a	g.chr2:45774718T>A	ENST00000263736.4	-	13	1771	c.1709A>T	c.(1708-1710)cAt>cTt	p.H570L	SRBD1_ENST00000535761.1_Missense_Mutation_p.H89L	NM_018079.4	NP_060549.4	Q8N5C6	SRBD1_HUMAN	S1 RNA binding domain 1	570					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		hydrolase activity, acting on ester bonds|RNA binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(13)|large_intestine(8)|lung(15)|skin(2)|stomach(1)|urinary_tract(1)	49		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)	LUSC - Lung squamous cell carcinoma(58;0.0917)|Lung(47;0.154)			TTGTCCACAATGCAAGTAAAC	0.323000													7	36					0	0	1	0	0
VEGFC	7424	broad.mit.edu	37	4	177648996	177648996	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7941-01A-11D-2184-08	TCGA-97-7941-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61181eca-24b7-4256-bf0b-7902359e4f4b	eb7be5ed-361f-463a-aa9d-6408387ded3a	g.chr4:177648996C>A	ENST00000280193.2	-	3	903	c.488G>T	c.(487-489)gGg>gTg	p.G163V	VEGFC_ENST00000507638.1_5'UTR	NM_005429.2	NP_005420.1	P49767	VEGFC_HUMAN	vascular endothelial growth factor C	163					angiogenesis|induction of positive chemotaxis|platelet activation|platelet degranulation|positive regulation of cell division|positive regulation of mast cell chemotaxis|substrate-dependent cell migration|vascular endothelial growth factor receptor signaling pathway	membrane|platelet alpha granule lumen	chemoattractant activity|growth factor activity			biliary_tract(1)|cervix(1)|large_intestine(6)|lung(28)|pancreas(1)|prostate(2)|skin(2)	41		Breast(14;0.000223)|Renal(120;0.00988)|Prostate(90;0.00996)|Melanoma(52;0.0101)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;1.59e-18)|Epithelial(43;3.68e-16)|OV - Ovarian serous cystadenocarcinoma(60;8.52e-09)|GBM - Glioblastoma multiforme(59;0.000546)|STAD - Stomach adenocarcinoma(60;0.00308)|Colorectal(24;0.025)|COAD - Colon adenocarcinoma(29;0.0359)|LUSC - Lung squamous cell carcinoma(193;0.0397)		GCAGCAACCCCCACATCTGTA	0.547000													20	109					1.87028e-06	2.26403e-06	1	1	0
FAT2	2196	broad.mit.edu	37	5	150920132	150920132	+	Nonsense_Mutation	SNP	G	G	T			TCGA-97-7941-01A-11D-2184-08	TCGA-97-7941-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61181eca-24b7-4256-bf0b-7902359e4f4b	eb7be5ed-361f-463a-aa9d-6408387ded3a	g.chr5:150920132G>T	ENST00000261800.5	-	10	9047	c.9035C>A	c.(9034-9036)tCa>tAa	p.S3012*		NM_001447.2	NP_001438.1	Q9NYQ8	FAT2_HUMAN	FAT atypical cadherin 2	3012	Cadherin 27.				epithelial cell migration|homophilic cell adhesion	cell-cell adherens junction|integral to membrane|nucleus	calcium ion binding			NS(6)|breast(3)|central_nervous_system(3)|cervix(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(61)|liver(1)|lung(60)|ovary(6)|prostate(5)|skin(5)|stomach(2)|upper_aerodigestive_tract(11)|urinary_tract(1)	196		Medulloblastoma(196;0.0912)|all_hematologic(541;0.104)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			TCTCACCTGTGAACACTGTGG	0.532000													4	26					0.00909568	0.00943762	1	1	0
DYNC1I1	1780	broad.mit.edu	37	7	95625311	95625311	+	Nonsense_Mutation	SNP	G	G	T			TCGA-97-7941-01A-11D-2184-08	TCGA-97-7941-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61181eca-24b7-4256-bf0b-7902359e4f4b	eb7be5ed-361f-463a-aa9d-6408387ded3a	g.chr7:95625311G>T	ENST00000324972.6	+	10	1139	c.946G>T	c.(946-948)Gaa>Taa	p.E316*	DYNC1I1_ENST00000457059.1_Nonsense_Mutation_p.E299*|DYNC1I1_ENST00000447467.2_Nonsense_Mutation_p.E299*|DYNC1I1_ENST00000537881.1_Nonsense_Mutation_p.E279*|DYNC1I1_ENST00000437599.1_Nonsense_Mutation_p.E296*|DYNC1I1_ENST00000359388.4_Nonsense_Mutation_p.E279*	NM_004411.4	NP_004402.1	O14576	DC1I1_HUMAN	dynein, cytoplasmic 1, intermediate chain 1	316					vesicle transport along microtubule	condensed chromosome kinetochore|cytoplasmic dynein complex|microtubule|perinuclear region of cytoplasm|spindle pole|vesicle	microtubule binding|microtubule motor activity			NS(2)|autonomic_ganglia(1)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(10)|lung(27)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	54	all_cancers(62;9.39e-10)|all_epithelial(64;2.28e-09)|Lung NSC(181;0.165)|all_lung(186;0.191)		STAD - Stomach adenocarcinoma(171;0.0957)			TGCTCCCCATGAACCAGATGG	0.428000													8	131					0.00307968	0.00324424	1	1	0
BZW2	28969	broad.mit.edu	37	7	16744259	16744259	+	Missense_Mutation	SNP	A	A	G			TCGA-97-7941-01A-11D-2184-08	TCGA-97-7941-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61181eca-24b7-4256-bf0b-7902359e4f4b	eb7be5ed-361f-463a-aa9d-6408387ded3a	g.chr7:16744259A>G	ENST00000433922.2	+	11	1374	c.1196A>G	c.(1195-1197)aAg>aGg	p.K399R	AC073333.8_ENST00000418907.1_RNA|BZW2_ENST00000405202.1_Missense_Mutation_p.K323R|BZW2_ENST00000258761.3_Missense_Mutation_p.K399R|BZW2_ENST00000407633.1_Missense_Mutation_p.K205R	NM_001159767.1	NP_001153239.1	Q9Y6E2	BZW2_HUMAN	basic leucine zipper and W2 domains 2	399	W2.				cell differentiation|nervous system development|RNA metabolic process		protein binding			cervix(1)|endometrium(1)|kidney(4)|large_intestine(3)|lung(2)|ovary(2)|skin(1)|urinary_tract(1)	15	Lung NSC(10;0.0367)|all_lung(11;0.0837)			UCEC - Uterine corpus endometrioid carcinoma (126;0.199)		GACCAGATGAAGAAATTTGTT	0.328000													12	40					0	0	1	0	0
CCDC86	79080	broad.mit.edu	37	11	60615506	60615506	+	Nonsense_Mutation	SNP	G	G	T			TCGA-97-7941-01A-11D-2184-08	TCGA-97-7941-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61181eca-24b7-4256-bf0b-7902359e4f4b	eb7be5ed-361f-463a-aa9d-6408387ded3a	g.chr11:60615506G>T	ENST00000227520.5	+	2	922	c.868G>T	c.(868-870)Gag>Tag	p.E290*	CCDC86_ENST00000545580.1_Nonsense_Mutation_p.E34*|RP11-804A23.4_ENST00000538705.1_RNA	NM_024098.3	NP_077003.1	Q9H6F5	CCD86_HUMAN	coiled-coil domain containing 86	290					interspecies interaction between organisms	nucleus				endometrium(1)|large_intestine(2)|liver(2)|lung(2)|urinary_tract(3)	10						CCTGGAGGAGGAGAAGGAGAG	0.627000													9	38					0.0477658	0.0484682	1	1	0
CCDC172	374355	broad.mit.edu	37	10	118137968	118137968	+	Silent	SNP	T	T	C			TCGA-97-7941-01A-11D-2184-08	TCGA-97-7941-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61181eca-24b7-4256-bf0b-7902359e4f4b	eb7be5ed-361f-463a-aa9d-6408387ded3a	g.chr10:118137968T>C	ENST00000333254.3	+	8	938	c.687T>C	c.(685-687)gaT>gaC	p.D229D		NM_198515.2	NP_940917.1			coiled-coil domain containing 172																		ATAAGGAAGATGACATGGAAA	0.274000													8	51					0	0	1	0	0
KAT6A	7994	broad.mit.edu	37	8	41792359	41792359	+	Missense_Mutation	SNP	G	G	A			TCGA-97-7941-01A-11D-2184-08	TCGA-97-7941-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61181eca-24b7-4256-bf0b-7902359e4f4b	eb7be5ed-361f-463a-aa9d-6408387ded3a	g.chr8:41792359G>A	ENST00000396930.3	-	18	3922	c.3379C>T	c.(3379-3381)Ctt>Ttt	p.L1127F	KAT6A_ENST00000265713.2_Missense_Mutation_p.L1127F|KAT6A_ENST00000406337.1_Missense_Mutation_p.L1127F	NM_001099412.1	NP_001092882.1	Q92794	MYST3_HUMAN	K(lysine) acetyltransferase 6A	1127					histone H3 acetylation|myeloid cell differentiation|negative regulation of transcription, DNA-dependent|nucleosome assembly|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	MOZ/MORF histone acetyltransferase complex|nucleosome	DNA binding|histone acetyltransferase activity|transcription coactivator activity|transcription factor binding|zinc ion binding										TTTCGCAAAAGAGATACTGGC	0.413000													14	176					0	0	1	0	0
LTF	4057	broad.mit.edu	37	3	46486797	46486797	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7941-01A-11D-2184-08	TCGA-97-7941-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61181eca-24b7-4256-bf0b-7902359e4f4b	eb7be5ed-361f-463a-aa9d-6408387ded3a	g.chr3:46486797G>T	ENST00000231751.4	-	12	1783	c.1488C>A	c.(1486-1488)ttC>ttA	p.F496L	LTF_ENST00000426532.2_Missense_Mutation_p.F452L|LTF_ENST00000417439.1_Missense_Mutation_p.F494L	NM_002343.3	NP_002334.2	P02788	TRFL_HUMAN	lactotransferrin	496	Transferrin-like 2.				cellular iron ion homeostasis|defense response to bacterium|humoral immune response|iron ion transport	extracellular region|stored secretory granule	ferric iron binding|heparin binding|protein binding|serine-type endopeptidase activity			NS(1)|breast(3)|central_nervous_system(3)|endometrium(4)|kidney(3)|large_intestine(5)|lung(13)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)	40				all cancers(1;7.55e-14)|GBM - Glioblastoma multiforme(1;2.1e-09)|Epithelial(1;9.25e-07)|Colorectal(1;3.81e-05)|BRCA - Breast invasive adenocarcinoma(193;0.00129)|COAD - Colon adenocarcinoma(1;0.00308)|KIRC - Kidney renal clear cell carcinoma(197;0.0205)|Kidney(197;0.0242)|OV - Ovarian serous cystadenocarcinoma(275;0.089)	Pefloxacin(DB00487)	CCGTCTGGTTGAAGAGCAGGC	0.567000													6	96					0.000157383	0.000175152	1	1	0
TRBV10-1	28585	broad.mit.edu	37	7	142231664	142231664	+	RNA	SNP	C	C	A			TCGA-97-7941-01A-11D-2184-08	TCGA-97-7941-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61181eca-24b7-4256-bf0b-7902359e4f4b	eb7be5ed-361f-463a-aa9d-6408387ded3a	g.chr7:142231664C>A	ENST00000390364.3	-	0	320																											GATCTAGAGACACTGTAGCCA	0.512000													18	110					4.96729e-08	6.59121e-08	1	1	0
UNC5C	8633	broad.mit.edu	37	4	96140183	96140183	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7941-01A-11D-2184-08	TCGA-97-7941-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61181eca-24b7-4256-bf0b-7902359e4f4b	eb7be5ed-361f-463a-aa9d-6408387ded3a	g.chr4:96140183G>T	ENST00000453304.1	-	9	1930	c.1582C>A	c.(1582-1584)Cca>Aca	p.P528T	UNC5C_ENST00000506749.1_Missense_Mutation_p.P547T	NM_003728.3	NP_003719.3	O95185	UNC5C_HUMAN	unc-5 homolog C (C. elegans)	528	ZU5.				apoptosis|axon guidance|brain development	integral to membrane	netrin receptor activity			NS(1)|breast(2)|endometrium(2)|kidney(1)|large_intestine(14)|lung(25)|ovary(3)|pancreas(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	55		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;8.72e-10)		GTACAGGATGGATCAGTCTGC	0.493000													10	84					0.0167234	0.017095	1	1	0
MRPL53	116540	broad.mit.edu	37	2	74699360	74699360	+	Missense_Mutation	SNP	A	A	T			TCGA-97-7941-01A-11D-2184-08	TCGA-97-7941-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61181eca-24b7-4256-bf0b-7902359e4f4b	eb7be5ed-361f-463a-aa9d-6408387ded3a	g.chr2:74699360A>T	ENST00000409710.1	-	2	138	c.112T>A	c.(112-114)Tat>Aat	p.Y38N	MRPL53_ENST00000258105.7_Silent_p.I75I			Q96EL3	RM53_HUMAN	mitochondrial ribosomal protein L53	0						mitochondrion|ribosome				central_nervous_system(1)|large_intestine(2)|lung(1)|urinary_tract(1)	5						CGCCGCGCATAATCAGGCGAT	0.682000													5	24					0	0	1	0	0
SPHKAP	80309	broad.mit.edu	37	2	228856017	228856017	+	Missense_Mutation	SNP	G	G	A			TCGA-97-7941-01A-11D-2184-08	TCGA-97-7941-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61181eca-24b7-4256-bf0b-7902359e4f4b	eb7be5ed-361f-463a-aa9d-6408387ded3a	g.chr2:228856017G>A	ENST00000392056.3	-	10	4793	c.4747C>T	c.(4747-4749)Ctt>Ttt	p.L1583F	SPHKAP_ENST00000344657.5_Missense_Mutation_p.L1554F	NM_001142644.1	NP_001136116.1	Q2M3C7	SPKAP_HUMAN	SPHK1 interactor, AKAP domain containing	1583						cytoplasm	protein binding			NS(5)|breast(5)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(25)|lung(86)|ovary(6)|pancreas(1)|prostate(6)|skin(17)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	185		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;8.17e-11)|all cancers(144;7.92e-08)|Lung(261;0.0168)|LUSC - Lung squamous cell carcinoma(224;0.0232)		TGTCCTTTAAGAATCTTCTTT	0.413000													8	84					0	0	1	0	0
ZBTB49	166793	broad.mit.edu	37	4	4322915	4322915	+	Missense_Mutation	SNP	G	G	T	rs145779018		TCGA-97-7941-01A-11D-2184-08	TCGA-97-7941-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61181eca-24b7-4256-bf0b-7902359e4f4b	eb7be5ed-361f-463a-aa9d-6408387ded3a	g.chr4:4322915G>T	ENST00000337872.4	+	8	2291	c.2170G>T	c.(2170-2172)Ggt>Tgt	p.G724C	ZBTB49_ENST00000538529.1_Missense_Mutation_p.G207C|ZBTB49_ENST00000355834.3_Missense_Mutation_p.G602C	NM_145291.3	NP_660334.3	Q6ZSB9	ZBT49_HUMAN	zinc finger and BTB domain containing 49	724					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(3)|kidney(3)|large_intestine(5)|lung(9)|ovary(1)|prostate(1)|skin(2)|stomach(1)|urinary_tract(1)	28						CAACCACGGCGGTGACCCCCT	0.587000													6	35					0.00116845	0.00124996	1	1	0
MFAP3L	9848	broad.mit.edu	37	4	170913125	170913125	+	Missense_Mutation	SNP	T	T	A			TCGA-97-7941-01A-11D-2184-08	TCGA-97-7941-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61181eca-24b7-4256-bf0b-7902359e4f4b	eb7be5ed-361f-463a-aa9d-6408387ded3a	g.chr4:170913125T>A	ENST00000361618.3	-	3	941	c.634A>T	c.(634-636)Acc>Tcc	p.T212S	MFAP3L_ENST00000393704.3_Missense_Mutation_p.T109S|RP11-6E9.4_ENST00000508955.1_RNA	NM_021647.6	NP_067679.6	O75121	MFA3L_HUMAN	microfibrillar-associated protein 3-like	212						integral to membrane|plasma membrane				cervix(1)|endometrium(4)|kidney(1)|large_intestine(6)|lung(5)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	22		Prostate(90;0.00601)|Renal(120;0.0183)|all_neural(102;0.122)|Melanoma(52;0.17)		GBM - Glioblastoma multiforme(119;0.0201)|LUSC - Lung squamous cell carcinoma(193;0.116)		TTGGCGGAGGTGATGATGGGG	0.532000													11	55					0	0	1	0	0
SPAG6	9576	broad.mit.edu	37	10	22675764	22675764	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7941-01A-11D-2184-08	TCGA-97-7941-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61181eca-24b7-4256-bf0b-7902359e4f4b	eb7be5ed-361f-463a-aa9d-6408387ded3a	g.chr10:22675764G>T	ENST00000376603.2	+	5	924	c.782G>T	c.(781-783)aGg>aTg	p.R261M	RP11-301N24.3_ENST00000422675.1_RNA|SPAG6_ENST00000376624.3_Missense_Mutation_p.R185M|SPAG6_ENST00000376601.1_Intron|SPAG6_ENST00000538630.1_Missense_Mutation_p.R160M|SPAG6_ENST00000313311.6_Missense_Mutation_p.R185M			O75602	SPAG6_HUMAN	sperm associated antigen 6	185					cell projection organization|spermatid development	axoneme|cilium|cytoplasm|flagellum|microtubule	binding			breast(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(13)|prostate(1)|skin(2)	27						GCTTTGAAAAGGATTGCTGCT	0.473000													19	79					1.50039e-11	2.17951e-11	1	1	0
PTK2B	2185	broad.mit.edu	37	8	27289812	27289812	+	Silent	SNP	C	C	T			TCGA-97-7941-01A-11D-2184-08	TCGA-97-7941-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61181eca-24b7-4256-bf0b-7902359e4f4b	eb7be5ed-361f-463a-aa9d-6408387ded3a	g.chr8:27289812C>T	ENST00000397501.1	+	15	1729	c.921C>T	c.(919-921)tcC>tcT	p.S307S	PTK2B_ENST00000544172.1_Silent_p.S307S|PTK2B_ENST00000397497.4_Silent_p.S53S|PTK2B_ENST00000346049.5_Silent_p.S307S|PTK2B_ENST00000338238.4_Silent_p.S307S|PTK2B_ENST00000420218.2_Silent_p.S307S|PTK2B_ENST00000517339.1_Silent_p.S307S	NM_173174.2	NP_775266.1	Q14289	FAK2_HUMAN	protein tyrosine kinase 2 beta	307	FERM.				apoptosis|bone resorption|positive regulation of cell proliferation|signal complex assembly	cytosol	ATP binding|non-membrane spanning protein tyrosine kinase activity|signal transducer activity			breast(2)|central_nervous_system(2)|endometrium(3)|kidney(1)|large_intestine(2)|lung(17)|ovary(4)|skin(12)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	47		Ovarian(32;2.72e-05)		UCEC - Uterine corpus endometrioid carcinoma (27;0.023)|Epithelial(17;6.61e-10)|BRCA - Breast invasive adenocarcinoma(99;0.226)|Colorectal(74;0.229)		AGATCAGGTCCATCAGGTGCC	0.617000													5	46					0	0	1	0	0
SYMPK	8189	broad.mit.edu	37	19	46319250	46319250	+	Silent	SNP	C	C	A			TCGA-97-7941-01A-11D-2184-08	TCGA-97-7941-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61181eca-24b7-4256-bf0b-7902359e4f4b	eb7be5ed-361f-463a-aa9d-6408387ded3a	g.chr19:46319250C>A	ENST00000245934.7	-	26	3790	c.3546G>T	c.(3544-3546)ccG>ccT	p.P1182P	SYMPK_ENST00000598155.1_5'UTR	NM_004819.2	NP_004810.2	Q92797	SYMPK_HUMAN	symplekin	1182					cell adhesion|mRNA processing	cytoplasm|cytoskeleton|nucleoplasm|tight junction	protein binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(7)|liver(1)|lung(25)|ovary(1)|urinary_tract(1)	45		all_neural(266;0.0299)|Ovarian(192;0.0308)		OV - Ovarian serous cystadenocarcinoma(262;0.00509)|GBM - Glioblastoma multiforme(486;0.0593)		CAGACGGGGGCGGGCCTGGCC	0.672000													4	15					2.0095e-06	2.4114e-06	1	1	0
ARMC3	219681	broad.mit.edu	37	10	23235079	23235079	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7941-01A-11D-2184-08	TCGA-97-7941-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61181eca-24b7-4256-bf0b-7902359e4f4b	eb7be5ed-361f-463a-aa9d-6408387ded3a	g.chr10:23235079C>A	ENST00000298032.5	+	3	139	c.55C>A	c.(55-57)Cca>Aca	p.P19T	ARMC3_ENST00000409049.3_Missense_Mutation_p.P19T|ARMC3_ENST00000376528.4_Intron|ARMC3_ENST00000409983.3_Missense_Mutation_p.P19T	NM_173081.3	NP_775104.2	Q5W041	ARMC3_HUMAN	armadillo repeat containing 3	19							binding			breast(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(24)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	47						TCAGTTTGACCCATTAATGAT	0.308000													5	39					3.59834e-05	4.10389e-05	1	1	0
FRK	2444	broad.mit.edu	37	6	116264242	116264242	+	Missense_Mutation	SNP	A	A	G			TCGA-97-7941-01A-11D-2184-08	TCGA-97-7941-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61181eca-24b7-4256-bf0b-7902359e4f4b	eb7be5ed-361f-463a-aa9d-6408387ded3a	g.chr6:116264242A>G	ENST00000606080.1	-	7	1693	c.1247T>C	c.(1246-1248)gTa>gCa	p.V416A	FRK_ENST00000538210.1_Missense_Mutation_p.V274A	NM_002031.2	NP_002022.1	P42685	FRK_HUMAN	fyn-related kinase	416	Protein kinase.				negative regulation of cell proliferation	cytoplasm|nucleus	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding			breast(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(10)|ovary(3)|pancreas(1)|skin(1)|urinary_tract(1)	27		all_cancers(87;0.00559)|all_epithelial(87;0.00738)|Colorectal(196;0.0465)		all cancers(137;0.0128)|OV - Ovarian serous cystadenocarcinoma(136;0.0209)|GBM - Glioblastoma multiforme(226;0.0459)|Epithelial(106;0.0625)		AAATGACCATACATCGGACTT	0.398000													5	55					0	0	1	0	0
SETD2	29072	broad.mit.edu	37	3	47103738	47103738	+	Nonsense_Mutation	SNP	G	G	A			TCGA-97-7941-01A-11D-2184-08	TCGA-97-7941-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61181eca-24b7-4256-bf0b-7902359e4f4b	eb7be5ed-361f-463a-aa9d-6408387ded3a	g.chr3:47103738G>A	ENST00000409792.3	-	14	6250	c.6208C>T	c.(6208-6210)Caa>Taa	p.Q2070*	SETD2_ENST00000492397.1_5'UTR	NM_014159.6	NP_054878.5	Q9BYW2	SETD2_HUMAN	SET domain containing 2	2070					regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	DNA binding|histone-lysine N-methyltransferase activity|oxidoreductase activity|transition metal ion binding			breast(6)|central_nervous_system(5)|endometrium(4)|kidney(63)|large_intestine(18)|lung(26)|ovary(6)|prostate(2)|skin(3)|soft_tissue(1)|stomach(2)|urinary_tract(5)	141		Acute lymphoblastic leukemia(5;0.0169)		BRCA - Breast invasive adenocarcinoma(193;0.000302)|KIRC - Kidney renal clear cell carcinoma(197;0.00732)|Kidney(197;0.00844)		TCTTTATTTTGAGTTTGCTTG	0.493000			"""N, F, S, Mis"""		clear cell renal carcinoma								29	168					0	0	1	0	0
CHERP	10523	broad.mit.edu	37	19	16640583	16640583	+	Silent	SNP	C	C	T			TCGA-97-7941-01A-11D-2184-08	TCGA-97-7941-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61181eca-24b7-4256-bf0b-7902359e4f4b	eb7be5ed-361f-463a-aa9d-6408387ded3a	g.chr19:16640583C>T	ENST00000546361.2	-	8	1156	c.1005G>A	c.(1003-1005)caG>caA	p.Q335Q	CHERP_ENST00000198939.6_Silent_p.Q346Q|CTD-3222D19.2_ENST00000409035.1_Intron	NM_006387.5	NP_006378.3	Q8IWX8	CHERP_HUMAN	calcium homeostasis endoplasmic reticulum protein	335	Gln-rich.				cellular calcium ion homeostasis|negative regulation of cell proliferation|nervous system development|RNA processing	endoplasmic reticulum|perinuclear region of cytoplasm	RNA binding			endometrium(3)|kidney(2)|large_intestine(4)|lung(9)|ovary(2)|stomach(1)|urinary_tract(3)	24						gctgctgttgctgctgctgct	0.667000													3	40					0	0	1	0	0
IGKV3D-11	28876	broad.mit.edu	37	2	90212092	90212092	+	RNA	SNP	C	C	T			TCGA-97-7941-01A-11D-2184-08	TCGA-97-7941-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61181eca-24b7-4256-bf0b-7902359e4f4b	eb7be5ed-361f-463a-aa9d-6408387ded3a	g.chr2:90212092C>T	ENST00000390277.2	+	0	281																											GAAACCTGGCCAGGCTCCCAG	0.592000													8	49					0	0	1	0	0
JAK2	3717	broad.mit.edu	37	9	5054630	5054630	+	Nonsense_Mutation	SNP	C	C	T			TCGA-97-7941-01A-11D-2184-08	TCGA-97-7941-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61181eca-24b7-4256-bf0b-7902359e4f4b	eb7be5ed-361f-463a-aa9d-6408387ded3a	g.chr9:5054630C>T	ENST00000381652.3	+	7	1176	c.682C>T	c.(682-684)Cga>Tga	p.R228*	JAK2_ENST00000544510.1_Nonsense_Mutation_p.R79*|JAK2_ENST00000539801.1_Nonsense_Mutation_p.R228*	NM_004972.3	NP_004963.1	O60674	JAK2_HUMAN	Janus kinase 2	228	FERM.|Interaction with cytokine/interferon/growth hormone receptors (By similarity).				actin filament polymerization|activation of caspase activity by protein phosphorylation|activation of JAK2 kinase activity|blood coagulation|cellular component movement|erythrocyte differentiation|interferon-gamma-mediated signaling pathway|interleukin-12-mediated signaling pathway|JAK-STAT cascade involved in growth hormone signaling pathway|mammary gland epithelium development|mesoderm development|negative regulation of cell proliferation|negative regulation of DNA binding|positive regulation of apoptosis|positive regulation of cell-substrate adhesion|positive regulation of growth hormone receptor signaling pathway|positive regulation of nitric-oxide synthase 2 biosynthetic process|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of tumor necrosis factor production|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of tyrosine phosphorylation of Stat5 protein|protein autophosphorylation|regulation of inflammatory response|regulation of interferon-gamma-mediated signaling pathway|response to antibiotic|response to lipopolysaccharide|STAT protein import into nucleus|tumor necrosis factor-mediated signaling pathway|tyrosine phosphorylation of STAT protein	caveola|cytoskeleton|cytosol|endomembrane system|nucleus	ATP binding|growth hormone receptor binding|heme binding|histone binding|histone kinase activity (H3-Y41 specific)|interleukin-12 receptor binding|non-membrane spanning protein tyrosine kinase activity|protein kinase binding|SH2 domain binding		BCR/JAK2(6)|SSBP2/JAK2(4)|SEC31A/JAK2(4)|ETV6/JAK2(11)|PCM1/JAK2(30)|PAX5/JAK2(18)	breast(5)|endometrium(4)|haematopoietic_and_lymphoid_tissue(32944)|kidney(4)|large_intestine(10)|liver(1)|lung(20)|ovary(3)|prostate(4)|skin(2)|urinary_tract(1)	32998	all_hematologic(13;0.137)	Acute lymphoblastic leukemia(23;0.0198)|Breast(48;0.147)		GBM - Glioblastoma multiforme(50;0.0237)|Lung(218;0.133)		GACAAGGAAGCGAATAAGGTA	0.348000		1	"""T, Mis, O"""	"""ETV6, PCM1, BCR"""	"""ALL, AML, MPD,  CML"""				Polycythemia Vera, Familial				12	126					0	0	1	0	0
KDM2B	84678	broad.mit.edu	37	12	121947779	121947779	+	Missense_Mutation	SNP	T	T	A			TCGA-97-7941-01A-11D-2184-08	TCGA-97-7941-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61181eca-24b7-4256-bf0b-7902359e4f4b	eb7be5ed-361f-463a-aa9d-6408387ded3a	g.chr12:121947779T>A	ENST00000377069.4	-	11	1551	c.1145A>T	c.(1144-1146)gAg>gTg	p.E382V	KDM2B_ENST00000536437.1_Missense_Mutation_p.E296V|KDM2B_ENST00000377071.4_Missense_Mutation_p.E413V|KDM2B_ENST00000538046.2_Missense_Mutation_p.E323V	NM_001005366.1	NP_001005366.1	Q8NHM5	KDM2B_HUMAN	lysine (K)-specific demethylase 2B	413					embryonic camera-type eye morphogenesis|fourth ventricle development|histone H2A monoubiquitination|initiation of neural tube closure|lateral ventricle development|midbrain development|midbrain-hindbrain boundary morphogenesis|negative regulation of neural precursor cell proliferation|negative regulation of neuron apoptosis|negative regulation of transcription from RNA polymerase II promoter|spermatogenesis|third ventricle development|transcription, DNA-dependent	nucleolus	DNA binding|histone demethylase activity (H3-K36 specific)|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|rRNA binding|zinc ion binding			breast(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(8)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	19						ATCACAGGCCTCCTCCTCCAT	0.627000													10	40					0	0	1	0	0
PRAMEF1	65121	broad.mit.edu	37	1	12855993	12855993	+	Missense_Mutation	SNP	G	G	A			TCGA-97-7941-01A-11D-2184-08	TCGA-97-7941-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61181eca-24b7-4256-bf0b-7902359e4f4b	eb7be5ed-361f-463a-aa9d-6408387ded3a	g.chr1:12855993G>A	ENST00000332296.7	+	4	1376	c.1273G>A	c.(1273-1275)Gtc>Atc	p.V425I	PRAMEF1_ENST00000400814.3_Missense_Mutation_p.V180I	NM_023013.2	NP_075389.1	O95521	PRAM1_HUMAN	PRAME family member 1	425										cervix(1)|endometrium(2)|kidney(3)|large_intestine(6)|lung(14)|ovary(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	35	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.0042)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;4.88e-06)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|COAD - Colon adenocarcinoma(227;0.000241)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		CTTGGTTCGTGTCAATTGGGA	0.577000													28	198					0	0	1	0	0
MRAP	56246	broad.mit.edu	37	21	33684278	33684278	+	Missense_Mutation	SNP	G	G	A			TCGA-97-7941-01A-11D-2184-08	TCGA-97-7941-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61181eca-24b7-4256-bf0b-7902359e4f4b	eb7be5ed-361f-463a-aa9d-6408387ded3a	g.chr21:33684278G>A	ENST00000399784.2	+	5	677	c.490G>A	c.(490-492)Gga>Aga	p.G164R	MRAP_ENST00000339944.4_Intron|MRAP_ENST00000303645.5_Missense_Mutation_p.G164R|MRAP_ENST00000497833.1_3'UTR|URB1_ENST00000382751.3_3'UTR|MRAP_ENST00000399786.3_Intron	NM_178817.3	NP_848932.1	Q8TCY5	MRAP_HUMAN	melanocortin 2 receptor accessory protein	164					positive regulation of cAMP biosynthetic process|protein localization at cell surface	endoplasmic reticulum|integral to membrane|perinuclear region of cytoplasm|plasma membrane	corticotropin hormone receptor binding|type 1 melanocortin receptor binding|type 3 melanocortin receptor binding|type 4 melanocortin receptor binding|type 5 melanocortin receptor binding			endometrium(1)|large_intestine(2)|lung(3)	6						GCCTCCCCCTGGAGACAGGAC	0.582000													15	59					0	0	1	0	0
HIST1H2BG	8339	broad.mit.edu	37	6	26216578	26216578	+	Silent	SNP	G	G	A			TCGA-97-7941-01A-11D-2184-08	TCGA-97-7941-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61181eca-24b7-4256-bf0b-7902359e4f4b	eb7be5ed-361f-463a-aa9d-6408387ded3a	g.chr6:26216578G>A	ENST00000244601.3	-	1	294	c.294C>T	c.(292-294)gcC>gcT	p.A98A		NM_003518.3	NP_003509.1	P62807	H2B1C_HUMAN	histone cluster 1, H2bg	98					defense response to bacterium|nucleosome assembly	nucleosome|nucleus	DNA binding|protein binding			endometrium(1)|large_intestine(1)|lung(3)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	8		all_hematologic(11;0.196)				GCAGACGCACGGCGGTCTGGA	0.572000													4	121					0	0	1	0	0
TPSD1	23430	broad.mit.edu	37	16	1306674	1306674	+	Silent	SNP	G	G	T			TCGA-97-7941-01A-11D-2184-08	TCGA-97-7941-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61181eca-24b7-4256-bf0b-7902359e4f4b	eb7be5ed-361f-463a-aa9d-6408387ded3a	g.chr16:1306674G>T	ENST00000211076.3	+	2	388	c.240G>T	c.(238-240)gcG>gcT	p.A80A	TPSD1_ENST00000397534.2_Silent_p.A73A	NM_012217.2	NP_036349.1	Q9BZJ3	TRYD_HUMAN	tryptase delta 1	80	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(9)|skin(1)|stomach(2)|upper_aerodigestive_tract(3)	20		Hepatocellular(780;0.00369)				TAACCGCGGCGCACTGCGTGG	0.701000													7	55					7.48243e-07	9.30248e-07	1	1	0
LDHA	3939	broad.mit.edu	37	11	18418443	18418443	+	Silent	SNP	C	C	A	rs11553865		TCGA-97-7941-01A-11D-2184-08	TCGA-97-7941-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61181eca-24b7-4256-bf0b-7902359e4f4b	eb7be5ed-361f-463a-aa9d-6408387ded3a	g.chr11:18418443C>A	ENST00000422447.3	+	2	327	c.54C>A	c.(52-54)acC>acA	p.T18T	LDHA_ENST00000540430.1_Silent_p.T47T|LDHA_ENST00000379412.5_Silent_p.T18T|LDHA_ENST00000542179.1_Silent_p.T18T|LDHA_ENST00000396222.2_Silent_p.T18T|LDHA_ENST00000227157.4_Silent_p.T18T|LDHA_ENST00000430553.2_Silent_p.T18T	NM_001135239.1|NM_005566.3	NP_001128711.1|NP_005557.1	P00338	LDHA_HUMAN	lactate dehydrogenase A	18					glycolysis|pyruvate metabolic process	cytosol	L-lactate dehydrogenase activity|protein binding			central_nervous_system(3)|endometrium(1)|large_intestine(4)|lung(4)	12					NADH(DB00157)	AAGAACAGACCCCCCAGAATA	0.418000													11	79					2.27111e-07	2.90197e-07	1	1	0
TTN	7273	broad.mit.edu	37	2	179456035	179456035	+	Silent	SNP	C	C	T			TCGA-97-7941-01A-11D-2184-08	TCGA-97-7941-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61181eca-24b7-4256-bf0b-7902359e4f4b	eb7be5ed-361f-463a-aa9d-6408387ded3a	g.chr2:179456035C>T	ENST00000589042.1	-	304	60641	c.60417G>A	c.(60415-60417)aaG>aaA	p.K20139K	TTN-AS1_ENST00000589907.1_RNA|TTN_ENST00000359218.5_Silent_p.K11199K|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000456053.1_RNA|TTN-AS1_ENST00000589234.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN_ENST00000591111.1_Silent_p.K18498K|TTN-AS1_ENST00000590932.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN_ENST00000342175.6_Silent_p.K11266K|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000342992.6_Silent_p.K17571K|TTN_ENST00000460472.2_Silent_p.K11074K	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	18498	Fibronectin type-III 46.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTAAGCAGTTCTTAATGGTAA	0.433000													13	402					0	0	1	0	0
FZD9	8326	broad.mit.edu	37	7	72849738	72849738	+	Silent	SNP	C	C	A			TCGA-97-7941-01A-11D-2184-08	TCGA-97-7941-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61181eca-24b7-4256-bf0b-7902359e4f4b	eb7be5ed-361f-463a-aa9d-6408387ded3a	g.chr7:72849738C>A	ENST00000344575.3	+	1	1630	c.1401C>A	c.(1399-1401)gtC>gtA	p.V467V		NM_003508.2	NP_003499.1	O00144	FZD9_HUMAN	frizzled family receptor 9	467					B cell differentiation|brain development|canonical Wnt receptor signaling pathway|embryo development|gonad development|neuroblast proliferation|vasculature development	cell surface|filopodium membrane|integral to membrane|perinuclear region of cytoplasm	G-protein coupled receptor activity|PDZ domain binding|protein heterodimerization activity|protein homodimerization activity|Wnt receptor activity|Wnt-protein binding			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(1)|lung(4)|prostate(2)|skin(1)	14		Lung NSC(55;0.0659)|all_lung(88;0.152)				TTTGCTATGTCTACGAACGCC	0.642000													5	20					8.12818e-05	9.11943e-05	1	1	0
LOC644669	644669	broad.mit.edu	37	18	15323276	15323276	+	RNA	SNP	A	A	T			TCGA-97-7941-01A-11D-2184-08	TCGA-97-7941-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61181eca-24b7-4256-bf0b-7902359e4f4b	eb7be5ed-361f-463a-aa9d-6408387ded3a	g.chr18:15323276A>T	ENST00000455308.2	-	0	572					NR_027417.1																						ATCAACTGCAATTGCATTTGC	0.308000													3	10					0	0	1	0	0
SIDT2	51092	broad.mit.edu	37	11	117063023	117063023	+	Silent	SNP	C	C	T			TCGA-97-7941-01A-11D-2184-08	TCGA-97-7941-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61181eca-24b7-4256-bf0b-7902359e4f4b	eb7be5ed-361f-463a-aa9d-6408387ded3a	g.chr11:117063023C>T	ENST00000324225.4	+	20	2457	c.1926C>T	c.(1924-1926)atC>atT	p.I642I	SIDT2_ENST00000431081.2_Silent_p.I639I	NM_001040455.1	NP_001035545.1	Q8NBJ9	SIDT2_HUMAN	SID1 transmembrane family, member 2	642						integral to membrane|lysosomal membrane				NS(1)|breast(2)|endometrium(4)|kidney(1)|large_intestine(9)|lung(11)|ovary(1)|prostate(4)|skin(1)|upper_aerodigestive_tract(2)	36	all_hematologic(175;0.0487)	Breast(348;0.00908)|Medulloblastoma(222;0.0425)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;1.69e-05)|Epithelial(105;0.000219)|all cancers(92;0.00144)		TCATTCACATCATCGCCACCC	0.637000													7	99					0	0	1	0	0
MYH8	4626	broad.mit.edu	37	17	10295215	10295215	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7941-01A-11D-2184-08	TCGA-97-7941-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61181eca-24b7-4256-bf0b-7902359e4f4b	eb7be5ed-361f-463a-aa9d-6408387ded3a	g.chr17:10295215C>A	ENST00000403437.2	-	39	5742	c.5648G>T	c.(5647-5649)aGa>aTa	p.R1883I	CTC-297N7.7_ENST00000399342.2_RNA|CTC-297N7.7_ENST00000581304.1_RNA|CTC-297N7.7_ENST00000587182.1_RNA	NM_002472.2	NP_002463.2	P13535	MYH8_HUMAN	myosin, heavy chain 8, skeletal muscle, perinatal	1883					muscle filament sliding	cytosol|muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			NS(3)|breast(8)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(61)|ovary(3)|prostate(3)|skin(10)|upper_aerodigestive_tract(2)|urinary_tract(2)	134						CTCAGCTTGTCTCTTGTATGA	0.378000									Trismus-Pseudocamptodactyly Syndrome with Cardiac Myxoma and Freckling				42	137					9.55421e-19	1.46498e-18	1	1	0
FAM47B	170062	broad.mit.edu	37	X	34962077	34962077	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7941-01A-11D-2184-08	TCGA-97-7941-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61181eca-24b7-4256-bf0b-7902359e4f4b	eb7be5ed-361f-463a-aa9d-6408387ded3a	g.chrX:34962077C>A	ENST00000329357.5	+	1	1165	c.1129C>A	c.(1129-1131)Cct>Act	p.P377T		NM_152631.2	NP_689844.2	Q8NA70	FA47B_HUMAN	family with sequence similarity 47, member B	377										breast(3)|central_nervous_system(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(13)|lung(28)|ovary(4)|prostate(3)|skin(2)|upper_aerodigestive_tract(3)	71						ACTCACCAAGCCTGGTAAATA	0.537000													12	39					1.49906e-05	1.7384e-05	1	1	0
SLC30A10	55532	broad.mit.edu	37	1	220088985	220088985	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7941-01A-11D-2184-08	TCGA-97-7941-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61181eca-24b7-4256-bf0b-7902359e4f4b	eb7be5ed-361f-463a-aa9d-6408387ded3a	g.chr1:220088985G>T	ENST00000366926.3	-	4	1425	c.1264C>A	c.(1264-1266)Ctg>Atg	p.L422M	SLC30A10_ENST00000536446.1_Missense_Mutation_p.L177M|SLC30A10_ENST00000484079.1_5'UTR	NM_018713.2	NP_061183.2	Q6XR72	ZNT10_HUMAN	solute carrier family 30, member 10	422					zinc ion transport	integral to membrane|plasma membrane	cation transmembrane transporter activity			NS(1)|endometrium(1)|large_intestine(1)|lung(9)|skin(1)	13				GBM - Glioblastoma multiforme(131;0.051)|all cancers(67;0.209)		ACGTGAGCCAGAGGCAGTGCC	0.567000													13	53					1.49906e-05	1.7384e-05	1	1	0
INSC	387755	broad.mit.edu	37	11	15243191	15243191	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7941-01A-11D-2184-08	TCGA-97-7941-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61181eca-24b7-4256-bf0b-7902359e4f4b	eb7be5ed-361f-463a-aa9d-6408387ded3a	g.chr11:15243191G>T	ENST00000379554.3	+	8	1175	c.1129G>T	c.(1129-1131)Gtc>Ttc	p.V377F	INSC_ENST00000379556.3_Missense_Mutation_p.V330F|INSC_ENST00000525218.1_Missense_Mutation_p.V288F|INSC_ENST00000528567.1_Missense_Mutation_p.V330F|INSC_ENST00000530161.1_Missense_Mutation_p.V330F|INSC_ENST00000424273.1_Missense_Mutation_p.V288F|INSC_ENST00000447214.2_3'UTR	NM_001031853.3	NP_001027024.3	Q1MX18	INSC_HUMAN	inscuteable homolog (Drosophila)	377					cell differentiation|nervous system development	cytoplasm	binding			NS(2)|breast(1)|central_nervous_system(2)|endometrium(6)|kidney(4)|large_intestine(3)|lung(24)|ovary(3)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	49						GACAGCCCTCGTCAGTGAGTC	0.617000													4	39					0.014758	0.0151985	1	1	0
SETD2	29072	broad.mit.edu	37	3	47158197	47158197	+	Missense_Mutation	SNP	C	C	G			TCGA-97-7941-01A-11D-2184-08	TCGA-97-7941-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61181eca-24b7-4256-bf0b-7902359e4f4b	eb7be5ed-361f-463a-aa9d-6408387ded3a	g.chr3:47158197C>G	ENST00000409792.3	-	4	4544	c.4502G>C	c.(4501-4503)tGt>tCt	p.C1501S		NM_014159.6	NP_054878.5	Q9BYW2	SETD2_HUMAN	SET domain containing 2	1501	AWS.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	DNA binding|histone-lysine N-methyltransferase activity|oxidoreductase activity|transition metal ion binding			breast(6)|central_nervous_system(5)|endometrium(4)|kidney(63)|large_intestine(18)|lung(26)|ovary(6)|prostate(2)|skin(3)|soft_tissue(1)|stomach(2)|urinary_tract(5)	141		Acute lymphoblastic leukemia(5;0.0169)		BRCA - Breast invasive adenocarcinoma(193;0.000302)|KIRC - Kidney renal clear cell carcinoma(197;0.00732)|Kidney(197;0.00844)		AAGAGGTGTACACTCACACTG	0.318000			"""N, F, S, Mis"""		clear cell renal carcinoma								16	71					0	0	1	0	0
MAB21L3	126868	broad.mit.edu	37	1	116675911	116675911	+	Silent	SNP	C	C	A			TCGA-97-7941-01A-11D-2184-08	TCGA-97-7941-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61181eca-24b7-4256-bf0b-7902359e4f4b	eb7be5ed-361f-463a-aa9d-6408387ded3a	g.chr1:116675911C>A	ENST00000369500.3	+	7	1279	c.1014C>A	c.(1012-1014)acC>acA	p.T338T		NM_152367.2	NP_689580.2	Q8N8X9	MB213_HUMAN	mab-21-like 3 (C. elegans)	338				T -> A (in Ref. 1; BAC04682 and 3; AAI28150).						breast(2)|endometrium(1)|large_intestine(3)|lung(8)|prostate(2)|skin(2)|urinary_tract(1)	19						TTCAGTGCACCAACCCGACTG	0.582000													6	130					8.12818e-05	9.11943e-05	1	1	0
MRPS5	64969	broad.mit.edu	37	2	95766248	95766248	+	Missense_Mutation	SNP	G	G	A			TCGA-97-7941-01A-11D-2184-08	TCGA-97-7941-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61181eca-24b7-4256-bf0b-7902359e4f4b	eb7be5ed-361f-463a-aa9d-6408387ded3a	g.chr2:95766248G>A	ENST00000272418.2	-	10	1110	c.902C>T	c.(901-903)aCg>aTg	p.T301M		NM_031902.3	NP_114108.1	P82675	RT05_HUMAN	mitochondrial ribosomal protein S5	301					translation	mitochondrion|ribosome	protein binding|RNA binding|structural constituent of ribosome			central_nervous_system(1)|kidney(2)|large_intestine(4)|lung(9)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	20						CTTGATATGCGTCCTTTTAAA	0.328000													3	46					0	0	1	0	0
GRID1	2894	broad.mit.edu	37	10	87628808	87628808	+	Missense_Mutation	SNP	G	G	C			TCGA-97-7941-01A-11D-2184-08	TCGA-97-7941-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61181eca-24b7-4256-bf0b-7902359e4f4b	eb7be5ed-361f-463a-aa9d-6408387ded3a	g.chr10:87628808G>C	ENST00000327946.7	-	6	995	c.910C>G	c.(910-912)Ctg>Gtg	p.L304V		NM_017551.2	NP_060021.1	Q9ULK0	GRID1_HUMAN	glutamate receptor, ionotropic, delta 1	304						cell junction|integral to membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity	p.L304M(1)		NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(24)|lung(46)|ovary(5)|prostate(4)|skin(5)|stomach(4)|upper_aerodigestive_tract(5)	106					L-Glutamic Acid(DB00142)	TCGCAGAGCAGGGAGGAGATG	0.577000										Multiple Myeloma(13;0.14)			16	75					0	0	1	0	0
TEX101	83639	broad.mit.edu	37	19	43920682	43920682	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7941-01A-11D-2184-08	TCGA-97-7941-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61181eca-24b7-4256-bf0b-7902359e4f4b	eb7be5ed-361f-463a-aa9d-6408387ded3a	g.chr19:43920682G>T	ENST00000602198.1	+	6	862	c.420G>T	c.(418-420)caG>caT	p.Q140H	TEX101_ENST00000253435.7_Missense_Mutation_p.Q140H|TEX101_ENST00000601707.1_3'UTR|TEX101_ENST00000598265.1_Missense_Mutation_p.Q122H	NM_031451.4	NP_113639.4	Q9BY14	TX101_HUMAN	testis expressed 101	122						anchored to membrane|plasma membrane				large_intestine(1)|lung(12)|ovary(1)|skin(1)	15		Prostate(69;0.0199)				GCCTGTCTCAGTTTTGGGAGT	0.483000													39	181					2.54354e-34	4.08149e-34	1	1	0
AHCTF1	25909	broad.mit.edu	37	1	247014516	247014516	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7941-01A-11D-2184-08	TCGA-97-7941-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61181eca-24b7-4256-bf0b-7902359e4f4b	eb7be5ed-361f-463a-aa9d-6408387ded3a	g.chr1:247014516C>A	ENST00000366508.1	-	33	5033	c.4897G>T	c.(4897-4899)Ggt>Tgt	p.G1633C	AHCTF1_ENST00000391829.2_Missense_Mutation_p.G1598C|AHCTF1_ENST00000326225.3_Missense_Mutation_p.G1607C|AHCTF1_ENST00000470300.1_5'UTR			Q8WYP5	ELYS_HUMAN	AT hook containing transcription factor 1	1598	Mediates transcriptional activity (By similarity).|Necessary for nuclear localization (By similarity).				cytokinesis|mitotic prometaphase|mRNA transport|nuclear pore complex assembly|protein transport|transmembrane transport	condensed chromosome kinetochore|cytosol|nuclear matrix|nuclear membrane|nuclear pore|nucleoplasm	DNA binding			NS(1)|breast(6)|cervix(3)|endometrium(8)|kidney(6)|large_intestine(12)|liver(2)|lung(21)|ovary(5)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	74	all_cancers(71;3.05e-05)|all_epithelial(71;6.72e-06)|Ovarian(71;0.0173)|Breast(184;0.0318)|all_lung(81;0.0458)|Lung NSC(105;0.0518)	all_cancers(173;0.0266)	OV - Ovarian serous cystadenocarcinoma(106;0.00271)			CCTTCTTCACCTTCCAATATC	0.413000													15	43					6.94344e-10	9.58195e-10	1	1	0
C20orf26	26074	broad.mit.edu	37	20	20172016	20172016	+	Missense_Mutation	SNP	G	G	A			TCGA-97-7941-01A-11D-2184-08	TCGA-97-7941-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61181eca-24b7-4256-bf0b-7902359e4f4b	eb7be5ed-361f-463a-aa9d-6408387ded3a	g.chr20:20172016G>A	ENST00000245957.5	+	15	1619	c.1543G>A	c.(1543-1545)Gaa>Aaa	p.E515K	C20orf26_ENST00000377309.2_5'UTR|C20orf26_ENST00000389656.3_5'UTR	NM_015585.3	NP_056400.3	Q8NHU2	CT026_HUMAN	chromosome 20 open reading frame 26	515										NS(2)|breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|lung(42)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	77				READ - Rectum adenocarcinoma(2;0.171)		ATTTGTAGCTGAAGTTGCAGA	0.343000													14	78					0	0	1	0	0
PKLR	5313	broad.mit.edu	37	1	155264336	155264336	+	Missense_Mutation	SNP	A	A	G			TCGA-97-7941-01A-11D-2184-08	TCGA-97-7941-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61181eca-24b7-4256-bf0b-7902359e4f4b	eb7be5ed-361f-463a-aa9d-6408387ded3a	g.chr1:155264336A>G	ENST00000392414.3	-	6	922	c.809T>C	c.(808-810)cTg>cCg	p.L270P	PKLR_ENST00000342741.4_Missense_Mutation_p.L301P	NM_181871.3	NP_870986.1	P30613	KPYR_HUMAN	pyruvate kinase, liver and RBC	301					endocrine pancreas development|energy reserve metabolic process|glycolysis|positive regulation of cellular metabolic process	cytosol	ATP binding|magnesium ion binding|potassium ion binding|pyruvate kinase activity			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(16)|ovary(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	35	all_lung(78;6.99e-23)|Hepatocellular(266;0.0877)|all_hematologic(923;0.145)		Epithelial(20;3.18e-10)|all cancers(21;7.9e-10)|BRCA - Breast invasive adenocarcinoma(34;0.00116)|LUSC - Lung squamous cell carcinoma(543;0.127)		Pyruvic acid(DB00119)	TTCCGGACCCAGAGCAGCCCT	0.612000													7	37					0	0	1	0	0
KRAS	3845	broad.mit.edu	37	12	25398284	25398284	+	Missense_Mutation	SNP	C	C	G	rs121913529		TCGA-97-7941-01A-11D-2184-08	TCGA-97-7941-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61181eca-24b7-4256-bf0b-7902359e4f4b	eb7be5ed-361f-463a-aa9d-6408387ded3a	g.chr12:25398284C>G	ENST00000311936.3	-	2	226	c.35G>C	c.(34-36)gGt>gCt	p.G12A	KRAS_ENST00000556131.1_Missense_Mutation_p.G12A|KRAS_ENST00000256078.4_Missense_Mutation_p.G12A|KRAS_ENST00000557334.1_Missense_Mutation_p.G12A	NM_004985.3	NP_004976.2	P01116	RASK_HUMAN	Kirsten rat sarcoma viral oncogene homolog	12			G -> A (in a colorectal cancer sample; somatic mutation).|G -> C (in lung carcinoma; somatic mutation).|G -> D (in pancreatic carcinoma, GASC and lung carcinoma; somatic mutation).|G -> R (in lung cancer and bladder cancer; somatic mutation).|G -> S (in lung carcinoma and GASC; somatic mutation).|G -> V (in lung carcinoma, pancreatic carcinoma, colon cancer and GASC; somatic mutation).		activation of MAPKK activity|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	plasma membrane	GTP binding|GTPase activity|protein binding	p.G12D(8562)|p.G12V(5775)|p.G12A(1407)|p.G12F(46)|p.G12L(8)|p.G12I(4)|p.G12E(3)|p.G12W(3)|p.G12Y(2)|p.G12fs*3(1)|p.G12C(1)|p.G12N(1)	UBE2L3/KRAS(2)	NS(6)|adrenal_gland(1)|autonomic_ganglia(3)|biliary_tract(532)|bone(2)|breast(32)|central_nervous_system(14)|cervix(50)|endometrium(411)|eye(4)|gastrointestinal_tract_(site_indeterminate)(7)|genital_tract(1)|haematopoietic_and_lymphoid_tissue(385)|kidney(8)|large_intestine(15267)|liver(29)|lung(3407)|oesophagus(16)|ovary(612)|pancreas(3739)|penis(1)|peritoneum(6)|prostate(96)|salivary_gland(6)|skin(45)|small_intestine(68)|soft_tissue(88)|stomach(207)|testis(17)|thymus(5)|thyroid(159)|upper_aerodigestive_tract(68)|urinary_tract(57)	25349	all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)		OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)			GCCTACGCCACCAGCTCCAAC	0.348000	G12A(KMS28BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(KPNSI9S_AUTONOMIC_GANGLIA)|G12A(MM1S_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(NCIH1573_LUNG)|G12A(NCIH2009_LUNG)|G12A(RERFLCAD1_LUNG)|G12A(RPMI8226_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(SW1116_LARGE_INTESTINE)|G12D(AGS_STOMACH)|G12D(ASPC1_PANCREAS)|G12D(COLO678_LARGE_INTESTINE)|G12D(HEC1A_ENDOMETRIUM)|G12D(HEC50B_ENDOMETRIUM)|G12D(HEYA8_OVARY)|G12D(HPAC_PANCREAS)|G12D(HPAFII_PANCREAS)|G12D(KARPAS620_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KP4_PANCREAS)|G12D(L33_PANCREAS)|G12D(LS180_LARGE_INTESTINE)|G12D(LS513_LARGE_INTESTINE)|G12D(MCAS_OVARY)|G12D(PANC0203_PANCREAS)|G12D(PANC0403_PANCREAS)|G12D(PANC0504_PANCREAS)|G12D(PANC0813_PANCREAS)|G12D(PANC1_PANCREAS)|G12D(PK1_PANCREAS)|G12D(PK59_PANCREAS)|G12D(SKLU1_LUNG)|G12D(SNUC2A_LARGE_INTESTINE)|G12D(SU8686_PANCREAS)|G12D(SUIT2_PANCREAS)|G12D(SW1990_PANCREAS)|G12V(A498_KIDNEY)|G12V(CAPAN2_PANCREAS)|G12V(CFPAC1_PANCREAS)|G12V(COLO668_LUNG)|G12V(CORL23_LUNG)|G12V(DANG_PANCREAS)|G12V(HCC56_LARGE_INTESTINE)|G12V(HUPT4_PANCREAS)|G12V(KP3_PANCREAS)|G12V(LCLC97TM1_LUNG)|G12V(NCIH2444_LUNG)|G12V(NCIH441_LUNG)|G12V(NCIH727_LUNG)|G12V(PANC0327_PANCREAS)|G12V(PATU8902_PANCREAS)|G12V(PATU8988S_PANCREAS)|G12V(QGP1_PANCREAS)|G12V(RCM1_LARGE_INTESTINE)|G12V(RERFLCAD2_LUNG)|G12V(RKN_OVARY)|G12V(SH10TC_STOMACH)|G12V(SHP77_LUNG)|G12V(SNGM_ENDOMETRIUM)|G12V(SW403_LARGE_INTESTINE)|G12V(SW480_LARGE_INTESTINE)|G12V(SW620_LARGE_INTESTINE)|G12V(SW900_LUNG)|G12V(YAPC_PANCREAS)	119	Mis		"""pancreatic, colorectal, lung, thyroid, AML, others"""				Noonan syndrome;Cardiofaciocutaneous syndrome	TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)			9	19					0	0	1	0	0
NFE2L2	4780	broad.mit.edu	37	2	178098809	178098809	+	Missense_Mutation	SNP	T	T	A			TCGA-97-7941-01A-11D-2184-08	TCGA-97-7941-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61181eca-24b7-4256-bf0b-7902359e4f4b	eb7be5ed-361f-463a-aa9d-6408387ded3a	g.chr2:178098809T>A	ENST00000397062.3	-	2	790	c.236A>T	c.(235-237)gAg>gTg	p.E79V	NFE2L2_ENST00000446151.2_Missense_Mutation_p.E63V|NFE2L2_ENST00000464747.1_Missense_Mutation_p.E63V|NFE2L2_ENST00000423513.1_Missense_Mutation_p.E63V|NFE2L2_ENST00000397063.4_Missense_Mutation_p.E63V	NM_006164.4	NP_006155.2	Q16236	NF2L2_HUMAN	nuclear factor, erythroid 2-like 2	79					transcription from RNA polymerase II promoter	centrosome|cytosol|nucleus|plasma membrane	protein dimerization activity|protein domain specific binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	p.E79G(1)|p.E79_T80insE(1)		central_nervous_system(1)|cervix(4)|endometrium(14)|kidney(5)|large_intestine(4)|liver(13)|lung(71)|oesophagus(29)|skin(2)|upper_aerodigestive_tract(11)|urinary_tract(4)	158			Epithelial(96;0.00442)|OV - Ovarian serous cystadenocarcinoma(117;0.00739)|all cancers(119;0.0195)|LUSC - Lung squamous cell carcinoma(2;0.036)|Lung(16;0.0935)			TTCACCTGTCTCTTCATCTAG	0.438000			Mis		"""NSCLC, HNSCC"""					HNSCC(56;0.16)			11	50					0	0	1	0	0
HAT1	8520	broad.mit.edu	37	2	172809485	172809485	+	Missense_Mutation	SNP	C	C	T			TCGA-97-7941-01A-11D-2184-08	TCGA-97-7941-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61181eca-24b7-4256-bf0b-7902359e4f4b	eb7be5ed-361f-463a-aa9d-6408387ded3a	g.chr2:172809485C>T	ENST00000264108.4	+	4	311	c.275C>T	c.(274-276)gCa>gTa	p.A92V	HAT1_ENST00000392584.1_Missense_Mutation_p.A7V|SLC25A12_ENST00000472748.1_Intron	NM_003642.3	NP_003633.1	O14929	HAT1_HUMAN	histone acetyltransferase 1	92					chromatin silencing at telomere|DNA packaging	cytoplasm|nuclear matrix|nucleoplasm	histone acetyltransferase activity|protein binding			breast(1)|kidney(1)|large_intestine(5)|liver(2)|lung(8)|ovary(1)|prostate(1)	19			OV - Ovarian serous cystadenocarcinoma(117;0.216)			GTTGAATATGCATCTAAAGTT	0.323000													4	79					0	0	1	0	0
CYP2A6	1548	broad.mit.edu	37	19	41349784	41349784	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7941-01A-11D-2184-08	TCGA-97-7941-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61181eca-24b7-4256-bf0b-7902359e4f4b	eb7be5ed-361f-463a-aa9d-6408387ded3a	g.chr19:41349784G>T	ENST00000301141.5	-	9	1422	c.1402C>A	c.(1402-1404)Cct>Act	p.P468T	CTC-490E21.12_ENST00000601627.1_Intron	NM_000762.5	NP_000753.3	P11509	CP2A6_HUMAN	cytochrome P450, family 2, subfamily A, polypeptide 6	468					coumarin catabolic process|exogenous drug catabolic process|steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|coumarin 7-hydroxylase activity|electron carrier activity|enzyme binding|heme binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(7)|lung(9)|ovary(3)|prostate(5)|skin(2)|upper_aerodigestive_tract(2)	37			LUSC - Lung squamous cell carcinoma(20;0.000219)|Lung(22;0.000959)		Chlorzoxazone(DB00356)|Diethylstilbestrol(DB00255)|Estradiol(DB00783)|Ethinyl Estradiol(DB00977)|Formoterol(DB00983)|Halothane(DB01159)|Letrozole(DB01006)|Methoxsalen(DB00553)|Metyrapone(DB01011)|Nicotine(DB00184)|Pilocarpine(DB01085)|Tolbutamide(DB01124)|Tranylcypromine(DB00752)	ATGTCCTTAGGTGACTGGGAG	0.572000													8	88					2.68362e-12	3.98215e-12	1	1	0
ALG10	84920	broad.mit.edu	37	12	34179154	34179154	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7941-01A-11D-2184-08	TCGA-97-7941-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61181eca-24b7-4256-bf0b-7902359e4f4b	eb7be5ed-361f-463a-aa9d-6408387ded3a	g.chr12:34179154G>T	ENST00000266483.2	+	3	1045	c.726G>T	c.(724-726)atG>atT	p.M242I	ALG10_ENST00000538927.1_Intron|RP11-847H18.2_ENST00000501954.2_RNA	NM_032834.3	NP_116223.3	Q5BKT4	AG10A_HUMAN	ALG10, alpha-1,2-glucosyltransferase	242					dolichol-linked oligosaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane|integral to membrane	dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity			NS(1)|breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(3)|lung(13)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	26	Lung NSC(5;3.82e-05)|Acute lymphoblastic leukemia(23;0.0142)|all_hematologic(23;0.0429)	Lung NSC(34;0.204)|all_lung(34;0.235)				CTTATTCCATGTCCTTTAAAA	0.368000													25	139					7.38237e-10	1.00868e-09	1	1	0
APOB	338	broad.mit.edu	37	2	21234526	21234526	+	Silent	SNP	G	G	C			TCGA-97-7941-01A-11D-2184-08	TCGA-97-7941-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61181eca-24b7-4256-bf0b-7902359e4f4b	eb7be5ed-361f-463a-aa9d-6408387ded3a	g.chr2:21234526G>C	ENST00000233242.1	-	26	5341	c.5214C>G	c.(5212-5214)ctC>ctG	p.L1738L		NM_000384.2	NP_000375.2	P04114	APOB_HUMAN	apolipoprotein B	1738					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			NS(5)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(19)|kidney(10)|large_intestine(63)|liver(5)|lung(125)|ovary(16)|pancreas(1)|prostate(5)|skin(31)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(6)	305	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	TGTCATTTGAGAGCTTAAGTC	0.418000													6	243					0	0	1	0	0
IFT172	26160	broad.mit.edu	37	2	27704107	27704107	+	Silent	SNP	C	C	A			TCGA-97-7941-01A-11D-2184-08	TCGA-97-7941-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61181eca-24b7-4256-bf0b-7902359e4f4b	eb7be5ed-361f-463a-aa9d-6408387ded3a	g.chr2:27704107C>A	ENST00000260570.3	-	8	694	c.591G>T	c.(589-591)ccG>ccT	p.P197P	IFT172_ENST00000359466.6_Silent_p.P197P|IFT172_ENST00000416524.2_Silent_p.P176P	NM_015662.1	NP_056477.1	Q9UG01	IF172_HUMAN	intraflagellar transport 172 homolog (Chlamydomonas)	197					cilium assembly	cilium	binding			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(17)|lung(17)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	43	Acute lymphoblastic leukemia(172;0.155)					AGGGTGGACACGGGTGGTTAA	0.483000													5	27					1.06961e-07	1.39252e-07	1	1	0
CDCA4	55038	broad.mit.edu	37	14	105477868	105477868	+	Silent	SNP	G	G	C			TCGA-97-7941-01A-11D-2184-08	TCGA-97-7941-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61181eca-24b7-4256-bf0b-7902359e4f4b	eb7be5ed-361f-463a-aa9d-6408387ded3a	g.chr14:105477868G>C	ENST00000336219.3	-	2	554	c.399C>G	c.(397-399)acC>acG	p.T133T	CDCA4_ENST00000392590.3_Silent_p.T133T	NM_017955.3	NP_060425.2	Q9BXL8	CDCA4_HUMAN	cell division cycle associated 4	133						nucleus				endometrium(1)|large_intestine(2)|lung(2)|ovary(1)	6		all_cancers(154;0.0798)|Melanoma(154;0.155)|all_epithelial(191;0.183)	OV - Ovarian serous cystadenocarcinoma(23;0.00778)|all cancers(16;0.00936)|Epithelial(46;0.0227)	Epithelial(152;0.142)		CCTGTGCTGAGGTGACTGGGC	0.592000													3	53					0	0	1	0	0
PCNXL3	399909	broad.mit.edu	37	11	65393401	65393401	+	Silent	SNP	A	A	G			TCGA-97-7941-01A-11D-2184-08	TCGA-97-7941-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61181eca-24b7-4256-bf0b-7902359e4f4b	eb7be5ed-361f-463a-aa9d-6408387ded3a	g.chr11:65393401A>G	ENST00000355703.3	+	20	3794	c.3255A>G	c.(3253-3255)gcA>gcG	p.A1085A		NM_032223.2	NP_115599.2	Q9H6A9	PCX3_HUMAN	pecanex-like 3 (Drosophila)	1085						integral to membrane				breast(1)|endometrium(2)|kidney(2)|large_intestine(1)|lung(6)|prostate(1)	13						TGTTGTACGCACTGGCTGGGG	0.632000											OREG0021084	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	11	50					0	0	1	0	0
IL12B	3593	broad.mit.edu	37	5	158743806	158743806	+	Missense_Mutation	SNP	C	C	A	rs150030340		TCGA-97-7941-01A-11D-2184-08	TCGA-97-7941-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61181eca-24b7-4256-bf0b-7902359e4f4b	eb7be5ed-361f-463a-aa9d-6408387ded3a	g.chr5:158743806C>A	ENST00000231228.2	-	7	1329	c.874G>T	c.(874-876)Gac>Tac	p.D292Y		NM_002187.2	NP_002178.2	P29460	IL12B_HUMAN	interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)	292	Fibronectin type-III.				cell cycle arrest|cell migration|defense response to Gram-negative bacterium|interferon-gamma biosynthetic process|natural killer cell activation|negative regulation of interleukin-10 production|negative regulation of interleukin-17 production|negative regulation of smooth muscle cell proliferation|positive regulation of activated T cell proliferation|positive regulation of activation of JAK2 kinase activity|positive regulation of cell adhesion|positive regulation of defense response to virus by host|positive regulation of granulocyte macrophage colony-stimulating factor production|positive regulation of interferon-gamma biosynthetic process|positive regulation of interferon-gamma production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 production|positive regulation of interleukin-17 production|positive regulation of memory T cell differentiation|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target|positive regulation of natural killer cell proliferation|positive regulation of NF-kappaB import into nucleus|positive regulation of NK T cell activation|positive regulation of NK T cell proliferation|positive regulation of osteoclast differentiation|positive regulation of smooth muscle cell apoptosis|positive regulation of T cell mediated cytotoxicity|positive regulation of T-helper 1 type immune response|positive regulation of T-helper 17 cell lineage commitment|positive regulation of T-helper 17 type immune response|positive regulation of tumor necrosis factor production|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of tyrosine phosphorylation of Stat4 protein|positive regulation of tyrosine phosphorylation of Stat5 protein|regulation of tyrosine phosphorylation of Stat1 protein|response to UV-B|sexual reproduction|T-helper 1 type immune response|T-helper cell differentiation	interleukin-12 complex|interleukin-23 complex|membrane	cytokine activity|cytokine receptor activity|interleukin-12 receptor binding|protein heterodimerization activity			cervix(1)|endometrium(1)|large_intestine(5)|lung(4)	11	Renal(175;0.00196)	Medulloblastoma(196;0.0354)|all_neural(177;0.138)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			GAGGTCTTGTCCGTGAAGACT	0.512000											OREG0016989	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	12	65					2.23348e-06	2.65708e-06	1	1	0
TMEM2	23670	broad.mit.edu	37	9	74360430	74360430	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7941-01A-11D-2184-08	TCGA-97-7941-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61181eca-24b7-4256-bf0b-7902359e4f4b	eb7be5ed-361f-463a-aa9d-6408387ded3a	g.chr9:74360430G>T	ENST00000377044.4	-	4	1077	c.538C>A	c.(538-540)Ctg>Atg	p.L180M	TMEM2_ENST00000377066.5_Missense_Mutation_p.L180M	NM_001135820.1|NM_013390.2	NP_001129292.1|NP_037522.1	Q9UHN6	TMEM2_HUMAN	transmembrane protein 2	180	G8.					integral to membrane				central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(15)|liver(1)|lung(19)|ovary(2)|prostate(5)|skin(1)|stomach(1)|urinary_tract(2)	56		all_epithelial(88;4.56e-14)|Myeloproliferative disorder(762;0.0255)		GBM - Glioblastoma multiforme(74;7.45e-21)|OV - Ovarian serous cystadenocarcinoma(323;1.02e-16)		TCCTGGATCAGGATGTAATGA	0.438000													13	91					2.31682e-05	2.66435e-05	1	1	0
SCARA5	286133	broad.mit.edu	37	8	27823930	27823930	+	Splice_Site	SNP	C	C	G			TCGA-97-7941-01A-11D-2184-08	TCGA-97-7941-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61181eca-24b7-4256-bf0b-7902359e4f4b	eb7be5ed-361f-463a-aa9d-6408387ded3a	g.chr8:27823930C>G	ENST00000354914.3	-	3	727		c.e3+1		SCARA5_ENST00000380385.2_Splice_Site|SCARA5_ENST00000518030.1_Intron|SCARA5_ENST00000524352.1_Splice_Site|SCARA5_ENST00000301906.4_Intron	NM_173833.5	NP_776194.2	Q6ZMJ2	SCAR5_HUMAN	scavenger receptor class A, member 5 (putative)						cellular iron ion homeostasis|endocytosis|iron ion transmembrane transport|protein homotrimerization	integral to plasma membrane	ferritin receptor activity|scavenger receptor activity			central_nervous_system(1)|large_intestine(6)|lung(5)|prostate(3)|skin(3)	18		Ovarian(32;0.0218)		UCEC - Uterine corpus endometrioid carcinoma (27;0.023)|KIRC - Kidney renal clear cell carcinoma(542;0.152)|Kidney(114;0.181)|Colorectal(74;0.228)		CCTGCTCTTACCTGCTAAGAT	0.542000													11	36					0	0	1	0	0
RANBP2	5903	broad.mit.edu	37	2	109347334	109347334	+	Missense_Mutation	SNP	G	G	A			TCGA-97-7941-01A-11D-2184-08	TCGA-97-7941-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61181eca-24b7-4256-bf0b-7902359e4f4b	eb7be5ed-361f-463a-aa9d-6408387ded3a	g.chr2:109347334G>A	ENST00000283195.6	+	3	371	c.245G>A	c.(244-246)tGt>tAt	p.C82Y		NM_006267.4	NP_006258.3	P49792	RBP2_HUMAN	RAN binding protein 2	82					carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA transport|protein folding|protein import into nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear pore	peptidyl-prolyl cis-trans isomerase activity|Ran GTPase binding|zinc ion binding		RANBP2/ALK(34)	NS(1)|biliary_tract(1)|breast(3)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(21)|large_intestine(19)|lung(51)|pancreas(1)|prostate(8)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(1)	129						GCCGTTGAATGTTACAGGGTA	0.343000													23	140					0	0	1	0	0
AIDA	64853	broad.mit.edu	37	1	222860943	222860943	+	Missense_Mutation	SNP	G	G	A			TCGA-97-7941-01A-11D-2184-08	TCGA-97-7941-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61181eca-24b7-4256-bf0b-7902359e4f4b	eb7be5ed-361f-463a-aa9d-6408387ded3a	g.chr1:222860943G>A	ENST00000340020.6	-	5	553	c.347C>T	c.(346-348)cCa>cTa	p.P116L	AIDA_ENST00000541237.1_Missense_Mutation_p.P92L|AIDA_ENST00000474863.1_5'UTR|AIDA_ENST00000355727.2_Missense_Mutation_p.P116L	NM_022831.2	NP_073742.2	Q96BJ3	AIDA_HUMAN	axin interactor, dorsalization associated	116					dorsal/ventral pattern formation|negative regulation of JNK cascade|negative regulation of JUN kinase activity|regulation of protein homodimerization activity					kidney(2)|large_intestine(2)|lung(5)|upper_aerodigestive_tract(1)	10						TTACCTTAATGGGACAGGCTG	0.269000													9	70					0	0	1	0	0
TMEM208	29100	broad.mit.edu	37	16	67262440	67262440	+	Missense_Mutation	SNP	C	C	T			TCGA-97-7941-01A-11D-2184-08	TCGA-97-7941-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61181eca-24b7-4256-bf0b-7902359e4f4b	eb7be5ed-361f-463a-aa9d-6408387ded3a	g.chr16:67262440C>T	ENST00000565201.1	+	4	256	c.205C>T	c.(205-207)Cac>Tac	p.H69Y	TMEM208_ENST00000563953.1_5'UTR|TMEM208_ENST00000563426.1_3'UTR|TMEM208_ENST00000304800.9_Missense_Mutation_p.H69Y			Q9BTX3	TM208_HUMAN	transmembrane protein 208	69						integral to membrane				breast(1)|kidney(2)|lung(1)|upper_aerodigestive_tract(1)	5		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.00067)|Epithelial(162;0.00442)|all cancers(182;0.0417)		GGCCAGCTACCACTCTATGAG	0.577000													6	15					0	0	1	0	0
CRX	1406	broad.mit.edu	37	19	48342874	48342874	+	Missense_Mutation	SNP	C	C	A			TCGA-97-7941-01A-11D-2184-08	TCGA-97-7941-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61181eca-24b7-4256-bf0b-7902359e4f4b	eb7be5ed-361f-463a-aa9d-6408387ded3a	g.chr19:48342874C>A	ENST00000221996.7	+	4	756	c.550C>A	c.(550-552)Ccg>Acg	p.P184T	TPRX2P_ENST00000535362.1_Intron|CRX_ENST00000539067.1_Missense_Mutation_p.P184T	NM_000554.4	NP_000545.1	O43186	CRX_HUMAN	cone-rod homeobox	184					organ morphogenesis|response to stimulus|visual perception		leucine zipper domain binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(11)|prostate(2)|urinary_tract(1)	23		all_cancers(25;2.76e-09)|all_epithelial(76;7.01e-07)|all_lung(116;2.48e-06)|Lung NSC(112;5.15e-06)|Ovarian(192;0.0139)|all_neural(266;0.0146)|Breast(70;0.133)		OV - Ovarian serous cystadenocarcinoma(262;0.000266)|all cancers(93;0.000788)|Epithelial(262;0.0226)|GBM - Glioblastoma multiforme(486;0.0521)		GGCCTCAGGGCCGTCTCTGAC	0.672000													6	34					1.06961e-07	1.39252e-07	1	1	0
AKAP4	8852	broad.mit.edu	37	X	49962221	49962221	+	Missense_Mutation	SNP	G	G	T			TCGA-97-7941-01A-11D-2184-08	TCGA-97-7941-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61181eca-24b7-4256-bf0b-7902359e4f4b	eb7be5ed-361f-463a-aa9d-6408387ded3a	g.chrX:49962221G>T	ENST00000376056.2	-	3	271	c.121C>A	c.(121-123)Ctg>Atg	p.L41M	AKAP4_ENST00000481402.1_5'UTR|AKAP4_ENST00000376058.2_Missense_Mutation_p.L41M|AKAP4_ENST00000358526.2_Missense_Mutation_p.L50M|AKAP4_ENST00000376064.3_Missense_Mutation_p.L41M			Q5JQC9	AKAP4_HUMAN	A kinase (PRKA) anchor protein 4	50					cell projection organization|single fertilization|sperm motility	cAMP-dependent protein kinase complex|cilium|cytoskeleton|microtubule-based flagellum	protein kinase A binding			NS(2)|breast(3)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(6)|large_intestine(6)|lung(14)|ovary(1)|skin(4)	41	Ovarian(276;0.236)					TCTACATTCAGGGTGGACACA	0.398000													5	49					1.12685e-05	1.32911e-05	1	1	0
CR2	1380	broad.mit.edu	37	1	207642509	207642509	+	Missense_Mutation	SNP	G	G	A			TCGA-97-7941-01A-11D-2184-08	TCGA-97-7941-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61181eca-24b7-4256-bf0b-7902359e4f4b	eb7be5ed-361f-463a-aa9d-6408387ded3a	g.chr1:207642509G>A	ENST00000367057.3	+	5	938	c.749G>A	c.(748-750)gGc>gAc	p.G250D	CR2_ENST00000367059.3_Missense_Mutation_p.G250D|CR2_ENST00000367058.3_Missense_Mutation_p.G250D|CR2_ENST00000458541.2_Missense_Mutation_p.G250D|CR2_ENST00000485707.1_3'UTR	NM_001006658.2	NP_001006659.1	P20023	CR2_HUMAN	complement component (3d/Epstein Barr virus) receptor 2	250	Sushi 4.				complement activation, classical pathway|innate immune response	integral to membrane|plasma membrane	complement receptor activity|protein homodimerization activity			NS(2)|breast(3)|endometrium(4)|kidney(3)|large_intestine(12)|lung(26)|ovary(1)|pancreas(1)|prostate(1)|skin(12)|upper_aerodigestive_tract(3)|urinary_tract(1)	69						CGACTGCAAGGCCCACCTTCT	0.473000													34	173					0	0	1	0	0
MROH8	140699	broad.mit.edu	37	20	35769666	35769666	+	Missense_Mutation	SNP	T	T	C			TCGA-97-7941-01A-11D-2184-08	TCGA-97-7941-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61181eca-24b7-4256-bf0b-7902359e4f4b	eb7be5ed-361f-463a-aa9d-6408387ded3a	g.chr20:35769666T>C	ENST00000400441.3	-	12	1386	c.1387A>G	c.(1387-1389)Aca>Gca	p.T463A	MROH8_ENST00000217333.8_Intron|MROH8_ENST00000441008.2_Missense_Mutation_p.T449A					maestro heat-like repeat family member 8									p.T463A(1)									GTATCAAATGTAGTCATTATA	0.378000													4	5					0	0	1	0	0
KRT16P6	353194	broad.mit.edu	37	17	16723379	16723379	+	RNA	SNP	C	C	A			TCGA-97-7941-01A-11D-2184-08	TCGA-97-7941-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61181eca-24b7-4256-bf0b-7902359e4f4b	eb7be5ed-361f-463a-aa9d-6408387ded3a	g.chr17:16723379C>A	ENST00000417510.1	-	0	740																											ATGTCGGCCCCCACACTCATG	0.557000													18	148					7.21436e-19	1.13134e-18	1	1	0
LEPROT	54741	broad.mit.edu	37	1	65895546	65895546	+	Splice_Site	SNP	G	G	T			TCGA-97-7941-01A-11D-2184-08	TCGA-97-7941-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61181eca-24b7-4256-bf0b-7902359e4f4b	eb7be5ed-361f-463a-aa9d-6408387ded3a	g.chr1:65895546G>T	ENST00000371065.4	+	3	232	c.92_splice	c.e3-1	p.V32_splice	LEPR_ENST00000349533.6_Intron|LEPR_ENST00000344610.8_Intron|LEPR_ENST00000406510.3_Intron|LEPR_ENST00000371059.3_Intron|LEPR_ENST00000371060.3_Intron|LEPROT_ENST00000484243.1_3'UTR	NM_001198681.1|NM_017526.4	NP_001185610.1|NP_059996.1	O15243	OBRG_HUMAN	leptin receptor overlapping transcript	32						endosome membrane|Golgi membrane|integral to plasma membrane				kidney(1)|large_intestine(1)|lung(5)	7				OV - Ovarian serous cystadenocarcinoma(397;0.00722)|KIRC - Kidney renal clear cell carcinoma(1967;0.094)		AACTGACAGCGTTTACTGGCC	0.398000													28	131					9.04072e-19	1.40182e-18	1	1	0
PCDHB16	57717	broad.mit.edu	37	5	140563505	140563505	+	Silent	SNP	C	C	A			TCGA-97-7941-01A-11D-2184-08	TCGA-97-7941-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61181eca-24b7-4256-bf0b-7902359e4f4b	eb7be5ed-361f-463a-aa9d-6408387ded3a	g.chr5:140563505C>A	ENST00000361016.2	+	1	2526	c.1371C>A	c.(1369-1371)acC>acA	p.T457T		NM_020957.1	NP_066008.1	Q9NRJ7	PCDBG_HUMAN		457	Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			breast(1)|endometrium(10)|kidney(3)|large_intestine(14)|lung(29)|ovary(5)|pancreas(2)|prostate(3)|skin(1)|urinary_tract(1)	69			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CCTCCTACACCCTGTTCGTCC	0.567000													28	157					6.97489e-18	1.05773e-17	1	1	0
ACSF3	197322	broad.mit.edu	37	16	89220529	89220529	+	Nonsense_Mutation	SNP	G	G	T			TCGA-97-7941-01A-11D-2184-08	TCGA-97-7941-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61181eca-24b7-4256-bf0b-7902359e4f4b	eb7be5ed-361f-463a-aa9d-6408387ded3a	g.chr16:89220529G>T	ENST00000317447.4	+	11	2022	c.1645G>T	c.(1645-1647)Gag>Tag	p.E549*	ACSF3_ENST00000406948.3_Nonsense_Mutation_p.E549*|ACSF3_ENST00000378345.4_Nonsense_Mutation_p.E284*|ACSF3_ENST00000537116.1_3'UTR	NM_001127214.2|NM_001243279.1|NM_174917.3	NP_001120686.1|NP_001230208.1|NP_777577.2	Q4G176	ACSF3_HUMAN	acyl-CoA synthetase family member 3	549					fatty acid metabolic process	mitochondrion	acid-thiol ligase activity|ATP binding			central_nervous_system(1)|endometrium(1)|kidney(2)|lung(9)|prostate(1)|urinary_tract(1)	15				BRCA - Breast invasive adenocarcinoma(80;0.0281)		GGTGCCCTCGGAGCTGGTGCT	0.637000													3	26					1	1	1	1	0
CPT2	1376	broad.mit.edu	37	1	53668099	53668099	+	Missense_Mutation	SNP	C	C	T	rs74315294	byFrequency	TCGA-97-7941-01A-11D-2184-08	TCGA-97-7941-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61181eca-24b7-4256-bf0b-7902359e4f4b	eb7be5ed-361f-463a-aa9d-6408387ded3a	g.chr1:53668099C>T	ENST00000371486.3	+	3	853	c.338C>T	c.(337-339)tCg>tTg	p.S113L	CPT2_ENST00000468572.1_3'UTR	NM_000098.2	NP_000089.1	P23786	CPT2_HUMAN	carnitine palmitoyltransferase 2	113			S -> L (in CPT2D; muscular form. Frequent mutation, may be a polymorphism as it found in some 'normal' cDNA seqeuences).		carnitine shuttle|fatty acid beta-oxidation|regulation of fatty acid oxidation	mitochondrial inner membrane	carnitine O-palmitoyltransferase activity			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(2)|lung(7)|skin(1)|upper_aerodigestive_tract(1)	15					L-Carnitine(DB00583)|Perhexiline(DB01074)	AGCTACATTTCGGGTAGGTAG	0.418000													5	63					0	0	1	0	0
TBL2	26608	broad.mit.edu	37	7	72988330	72988330	+	Silent	SNP	G	G	A			TCGA-97-7941-01A-11D-2184-08	TCGA-97-7941-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61181eca-24b7-4256-bf0b-7902359e4f4b	eb7be5ed-361f-463a-aa9d-6408387ded3a	g.chr7:72988330G>A	ENST00000305632.5	-	3	625	c.384C>T	c.(382-384)cgC>cgT	p.R128R	TBL2_ENST00000432538.1_Silent_p.R92R|TBL2_ENST00000459913.1_5'UTR|TBL2_ENST00000452475.1_Silent_p.R128R	NM_012453.2	NP_036585.1	Q9Y4P3	TBL2_HUMAN	transducin (beta)-like 2	128										endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(7)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	19		Lung NSC(55;0.0659)|all_lung(88;0.152)				CTCTCATGCTGCGGTGCTCTC	0.602000													18	79					0	0	1	0	0
CLOCK	9575	broad.mit.edu	37	4	56316293	56316305	+	Frame_Shift_Del	DEL	CTTGAACTCCGAG	CTTGAACTCCGAG	-	rs148913372		TCGA-97-7941-01A-11D-2184-08	TCGA-97-7941-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61181eca-24b7-4256-bf0b-7902359e4f4b	eb7be5ed-361f-463a-aa9d-6408387ded3a	g.chr4:56316293_56316305delCTTGAACTCCGAG	ENST00000309964.4	-	15	1551_1563	c.1301_1313delCTCGGAGTTCAAG	c.(1300-1314)tafs	p.SRSSR434fs	CLOCK_ENST00000381322.1_Frame_Shift_Del_p.SRSSR434fs|CLOCK_ENST00000513440.1_Frame_Shift_Del_p.SRSSR434fs	NM_004898.3	NP_004889.1	O15516	CLOCK_HUMAN	clock circadian regulator	434					circadian rhythm|photoperiodism|positive regulation of transcription from RNA polymerase II promoter	cytoplasm|transcription factor complex	DNA binding|histone acetyltransferase activity|sequence-specific DNA binding transcription factor activity|signal transducer activity			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(4)|kidney(5)|large_intestine(9)|lung(8)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	38	Lung NSC(11;0.00335)|Glioma(25;0.08)|all_epithelial(27;0.0992)|all_neural(26;0.101)		LUSC - Lung squamous cell carcinoma(4;1.62e-07)|Lung(4;1.34e-06)|Epithelial(7;0.0107)			AGATGATTTTCTTGAACTCCGAGAAGAGGCAGA	0.432													7	71	---	---	---	---					
FSTL5	56884	broad.mit.edu	37	4	162376268	162376268	+	Frame_Shift_Del	DEL	C	C	-			TCGA-97-7941-01A-11D-2184-08	TCGA-97-7941-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61181eca-24b7-4256-bf0b-7902359e4f4b	eb7be5ed-361f-463a-aa9d-6408387ded3a	g.chr4:162376268delC	ENST00000306100.5	-	15	2165	c.1729delG	c.(1729-1731)ccfs	p.A577fs	FSTL5_ENST00000536695.1_Frame_Shift_Del_p.A576fs|FSTL5_ENST00000379164.4_Frame_Shift_Del_p.A576fs|FSTL5_ENST00000427802.2_Frame_Shift_Del_p.A567fs	NM_001128427.2|NM_020116.4	NP_001121899.1|NP_064501.2	Q8N475	FSTL5_HUMAN	follistatin-like 5	577						extracellular region	calcium ion binding			central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(18)|lung(43)|ovary(4)|pancreas(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	91	all_hematologic(180;0.24)			COAD - Colon adenocarcinoma(41;0.179)		TTCCCACTGGCCAGGGTAATT	0.398													17	82	---	---	---	---					
LSM11	134353	broad.mit.edu	37	5	157171203	157171203	+	Frame_Shift_Del	DEL	C	C	-			TCGA-97-7941-01A-11D-2184-08	TCGA-97-7941-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61181eca-24b7-4256-bf0b-7902359e4f4b	eb7be5ed-361f-463a-aa9d-6408387ded3a	g.chr5:157171203delC	ENST00000286307.5	+	1	501	c.445delC	c.(445-447)ccfs	p.P149fs		NM_173491.2	NP_775762.1	P83369	LSM11_HUMAN	LSM11, U7 small nuclear RNA associated	149					histone mRNA 3'-end processing|S phase of mitotic cell cycle|termination of RNA polymerase II transcription	histone pre-mRNA 3'end processing complex|nucleoplasm|U7 snRNP	protein binding|U7 snRNA binding			breast(1)|kidney(1)|large_intestine(2)|lung(2)|prostate(1)	7	Renal(175;0.00488)	Medulloblastoma(196;0.0523)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			CACGCGAATGCCCTGTGAGTC	0.761													2	4	---	---	---	---					
SLC17A2	10246	broad.mit.edu	37	6	25921520	25921520	+	Frame_Shift_Del	DEL	T	T	-			TCGA-97-7941-01A-11D-2184-08	TCGA-97-7941-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61181eca-24b7-4256-bf0b-7902359e4f4b	eb7be5ed-361f-463a-aa9d-6408387ded3a	g.chr6:25921520delT	ENST00000377850.3	-	4	885	c.361delA	c.(361-363)tgfs	p.M121fs	SLC17A2_ENST00000265425.3_Frame_Shift_Del_p.M121fs|SLC17A2_ENST00000360488.3_Frame_Shift_Del_p.M121fs			O00624	NPT3_HUMAN	solute carrier family 17, member 2	121					phosphate metabolic process	integral to plasma membrane|membrane fraction	sodium:phosphate symporter activity	p.M121fs*7(1)		endometrium(3)|kidney(1)|large_intestine(9)|lung(12)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)	31						GCACCAAGCATTTTTTTTGCT	0.453													8	119	---	---	---	---					
TRA2A	29896	broad.mit.edu	37	7	23547133	23547135	+	In_Frame_Del	DEL	TTC	TTC	-			TCGA-97-7941-01A-11D-2184-08	TCGA-97-7941-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61181eca-24b7-4256-bf0b-7902359e4f4b	eb7be5ed-361f-463a-aa9d-6408387ded3a	g.chr7:23547133_23547135delTTC	ENST00000297071.4	-	5	761_763	c.545_547delGAA	c.(544-549)gtg>g	p.GM182del	TRA2A_ENST00000538367.1_In_Frame_Del_p.GM81del|TRA2A_ENST00000392502.4_In_Frame_Del_p.GM81del|TRA2A_ENST00000474586.1_5'UTR	NM_013293.3	NP_037425.1	Q13595	TRA2A_HUMAN	transformer 2 alpha homolog (Drosophila)	182	RRM.				nuclear mRNA splicing, via spliceosome	nucleus	nucleotide binding|RNA binding			endometrium(1)|large_intestine(1)|lung(6)|ovary(1)|prostate(1)	10						TCCAGCTCCATTCCATTTGCCCT	0.404													7	196	---	---	---	---					
GTF2IRD2P1	401375	broad.mit.edu	37	7	72664019	72664020	+	RNA	INS	-	-	T			TCGA-97-7941-01A-11D-2184-08	TCGA-97-7941-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61181eca-24b7-4256-bf0b-7902359e4f4b	eb7be5ed-361f-463a-aa9d-6408387ded3a	g.chr7:72664019_72664020insT	ENST00000425256.1	-	0	880_881					NR_002164.1																						CACCCCCGGGGCATGCCATCAA	0.505													2	4	---	---	---	---					
FBXO22	26263	broad.mit.edu	37	15	76225419	76225422	+	Frame_Shift_Del	DEL	CATA	CATA	-			TCGA-97-7941-01A-11D-2184-08	TCGA-97-7941-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61181eca-24b7-4256-bf0b-7902359e4f4b	eb7be5ed-361f-463a-aa9d-6408387ded3a	g.chr15:76225419_76225422delCATA	ENST00000308275.3	+	7	1293_1296	c.1188_1191delCATA	c.(1186-1191)ctfs	p.LI396fs	FBXO22_ENST00000540507.1_Frame_Shift_Del_p.LI292fs	NM_147188.2	NP_671717.1	Q8NEZ5	FBX22_HUMAN	F-box protein 22	396					ubiquitin-dependent protein catabolic process		ubiquitin-protein ligase activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(8)|pancreas(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	21						TAATGGCACTCATACATCTGGGGT	0.343													8	95	---	---	---	---					
LONP2	83752	broad.mit.edu	37	16	48382016	48382016	+	Frame_Shift_Del	DEL	G	G	-			TCGA-97-7941-01A-11D-2184-08	TCGA-97-7941-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61181eca-24b7-4256-bf0b-7902359e4f4b	eb7be5ed-361f-463a-aa9d-6408387ded3a	g.chr16:48382016delG	ENST00000285737.4	+	14	2245	c.2152delG	c.(2152-2154)gafs	p.G718fs	LONP2_ENST00000535754.1_Frame_Shift_Del_p.G674fs|LONP2_ENST00000564259.1_3'UTR	NM_031490.2	NP_113678.2	Q86WA8	LONP2_HUMAN	lon peptidase 2, peroxisomal	718					misfolded or incompletely synthesized protein catabolic process|protein targeting to peroxisome|signal peptide processing	nucleoid|peroxisomal matrix	ATP binding|ATP-dependent peptidase activity|enzyme binding|sequence-specific DNA binding|serine-type endopeptidase activity			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(13)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	31						TAAAGCTTTTGGAAGTTTTGA	0.358													15	66	---	---	---	---					
KRT16P4	339244	broad.mit.edu	37	17	18334177	18334177	+	RNA	DEL	T	T	-			TCGA-97-7941-01A-11D-2184-08	TCGA-97-7941-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61181eca-24b7-4256-bf0b-7902359e4f4b	eb7be5ed-361f-463a-aa9d-6408387ded3a	g.chr17:18334177delT	ENST00000580052.1	+	0	43																											TTCCTCTCTGTTTTTTTTTTC	0.572													2	4	---	---	---	---					
WIZ	58525	broad.mit.edu	37	19	15549931	15549933	+	In_Frame_Del	DEL	TCC	TCC	-			TCGA-97-7941-01A-11D-2184-08	TCGA-97-7941-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	61181eca-24b7-4256-bf0b-7902359e4f4b	eb7be5ed-361f-463a-aa9d-6408387ded3a	g.chr19:15549931_15549933delTCC	ENST00000389282.4	-	3	1941_1943	c.1728_1730delGGA	c.(1726-1731)gat>ga	p.ED576del	WIZ_ENST00000263381.6_Intron			O95785	WIZ_HUMAN	widely interspaced zinc finger motifs	576	Poly-Glu.					nucleus	zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(9)|ovary(1)|skin(1)|stomach(1)|urinary_tract(1)	24						CAGCACTACAtcctcctcctcct	0.611													2	4	---	---	---	---