Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
KLHL4	56062	broad.mit.edu	37	X	86773270	86773270	+	Missense_Mutation	SNP	A	A	G			TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chrX:86773270A>G	ENST00000373119.4	+	1	519	c.374A>G	c.(373-375)cAa>cGa	p.Q125R	KLHL4_ENST00000373114.4_Missense_Mutation_p.Q125R	NM_019117.4	NP_061990.2	Q9C0H6	KLHL4_HUMAN	kelch-like family member 4	125						cytoplasm|microtubule cytoskeleton|nucleolus	actin binding			NS(1)|biliary_tract(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(19)|lung(29)|ovary(2)|prostate(1)|skin(1)	67						AAACGCGCACAAGATTTGGAG	0.368000													57	34					0	0	1	0	0
OR10G2	26534	broad.mit.edu	37	14	22102281	22102281	+	Missense_Mutation	SNP	G	G	A			TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chr14:22102281G>A	ENST00000542433.1	-	1	815	c.718C>T	c.(718-720)Cgc>Tgc	p.R240C		NM_001005466.1	NP_001005466.1	Q8NGC3	O10G2_HUMAN	olfactory receptor, family 10, subfamily G, member 2	240					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(12)|prostate(1)|skin(2)|stomach(2)	22	all_cancers(95;0.00113)	Acute lymphoblastic leukemia(2;0.0279)		GBM - Glioblastoma multiforme(265;0.0142)		AAGGCCCGGCGCCTCCCATCA	0.552000													11	14					0	0	1	0	0
TMPRSS11B	132724	broad.mit.edu	37	4	69095207	69095207	+	Silent	SNP	G	G	C			TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chr4:69095207G>C	ENST00000332644.5	-	8	875	c.714C>G	c.(712-714)gtC>gtG	p.V238V		NM_182502.3	NP_872308.2	Q86T26	TM11B_HUMAN	transmembrane protease, serine 11B	238	Peptidase S1.				proteolysis	extracellular region|integral to plasma membrane	serine-type endopeptidase activity			breast(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(14)|ovary(1)|skin(1)	27						TTCCAAAGTTGACAGTCCAAT	0.338000													8	38					0	0	1	0	0
SAGE1	55511	broad.mit.edu	37	X	134993945	134993945	+	Missense_Mutation	SNP	C	C	G			TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chrX:134993945C>G	ENST00000535938.1	+	18	2521	c.2354C>G	c.(2353-2355)gCg>gGg	p.A785G	SAGE1_ENST00000324447.3_Missense_Mutation_p.A785G|SAGE1_ENST00000370709.3_Missense_Mutation_p.A785G|SAGE1_ENST00000537770.1_Missense_Mutation_p.A409G	NM_018666.2	NP_061136.2	Q9NXZ1	SAGE1_HUMAN	sarcoma antigen 1	785										breast(5)|endometrium(5)|large_intestine(10)|lung(23)|ovary(3)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	55	Acute lymphoblastic leukemia(192;0.000127)					AATGAATTTGCGGTAGGCACC	0.443000													34	85					0	0	1	0	0
PRB2	653247	broad.mit.edu	37	12	11546300	11546300	+	Missense_Mutation	SNP	G	G	T			TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chr12:11546300G>T	ENST00000389362.4	-	3	747	c.712C>A	c.(712-714)Cct>Act	p.P238T	PRB1_ENST00000546254.1_Intron	NM_006248.3	NP_006239.3			proline-rich protein BstNI subfamily 2											NS(1)|breast(1)|endometrium(2)|kidney(3)|large_intestine(3)|lung(14)|pancreas(1)|prostate(5)|skin(4)|stomach(2)|urinary_tract(1)	37		all_cancers(2;0.00558)|Acute lymphoblastic leukemia(2;3.94e-11)|all_hematologic(2;3.6e-09)	OV - Ovarian serous cystadenocarcinoma(49;0.185)			TTTCCTGGAGGAGATCGGGCA	0.612000													20	647					1.68575e-08	2.07022e-08	1	1	0
C6orf118	168090	broad.mit.edu	37	6	165715646	165715646	+	Translation_Start_Site	SNP	G	G	A			TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chr6:165715646G>A	ENST00000543069.1	-	0	434				C6orf118_ENST00000230301.8_Silent_p.D55D			Q5T5N4	CF118_HUMAN	chromosome 6 open reading frame 118									p.D55D(1)		breast(1)|kidney(2)|large_intestine(9)|liver(1)|lung(21)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	40		Breast(66;6.27e-05)|Ovarian(120;0.0228)|Prostate(117;0.0906)|all_neural(5;0.157)		OV - Ovarian serous cystadenocarcinoma(33;3.23e-18)|BRCA - Breast invasive adenocarcinoma(81;3.11e-06)|GBM - Glioblastoma multiforme(31;0.000313)		AGAGGTAGACGTCCTCCCGGT	0.557000													22	85					0	0	1	0	0
MXI1	4601	broad.mit.edu	37	10	111967665	111967665	+	Silent	SNP	C	C	A			TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chr10:111967665C>A	ENST00000332674.5	+	1	303	c.99C>A	c.(97-99)ccC>ccA	p.P33P	RP11-549L6.3_ENST00000451656.1_RNA	NM_130439.3	NP_569157.2	P50539	MXI1_HUMAN	MAX interactor 1, dimerization protein	45					cytoplasmic sequestering of transcription factor|negative regulation of cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|transcription corepressor activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|large_intestine(3)|lung(1)	10		Breast(234;0.052)|Lung NSC(174;0.223)		Epithelial(162;1.33e-05)|all cancers(201;0.000277)|BRCA - Breast invasive adenocarcinoma(275;0.127)		tggccgcgccccagcccccgg	0.751000													3	11					0.004672	0.00480941	1	1	0
FRMPD4	9758	broad.mit.edu	37	X	12701695	12701695	+	Missense_Mutation	SNP	G	G	A			TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chrX:12701695G>A	ENST00000380682.1	+	6	1068	c.562G>A	c.(562-564)Ggc>Agc	p.G188S		NM_014728.3	NP_055543.2	Q14CM0	FRPD4_HUMAN	FERM and PDZ domain containing 4	188					positive regulation of synapse structural plasticity	cytoskeleton|dendritic spine	phosphatidylinositol-4,5-bisphosphate binding|protein binding			breast(1)|central_nervous_system(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(1)|ovary(3)|pancreas(1)|skin(3)	22						CATCATCAACGGCCAAGTGTC	0.453000													5	14					0	0	1	0	0
CACNB2	783	broad.mit.edu	37	10	18828531	18828531	+	Missense_Mutation	SNP	T	T	A			TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chr10:18828531T>A	ENST00000396576.2	+	13	2197	c.1696T>A	c.(1696-1698)Tgc>Agc	p.C566S	CACNB2_ENST00000377315.4_Missense_Mutation_p.C573S|CACNB2_ENST00000377328.1_Missense_Mutation_p.C371S|CACNB2_ENST00000377319.3_Missense_Mutation_p.C528S|CACNB2_ENST00000377329.4_Missense_Mutation_p.C567S|CACNB2_ENST00000282343.8_Missense_Mutation_p.C593S|RP11-499P20.2_ENST00000425669.1_RNA|CACNB2_ENST00000377331.2_Missense_Mutation_p.C569S|CACNB2_ENST00000352115.6_Missense_Mutation_p.C597S|CACNB2_ENST00000324631.7_Missense_Mutation_p.C621S	NM_000724.3	NP_000715.2	Q08289	CACB2_HUMAN	calcium channel, voltage-dependent, beta 2 subunit	621					axon guidance|neuromuscular junction development	integral to plasma membrane|sarcolemma|voltage-gated calcium channel complex	protein binding|voltage-gated calcium channel activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(12)|prostate(1)|skin(3)|stomach(2)	31					Magnesium Sulfate(DB00653)|Verapamil(DB00661)	CCACAACGAGTGCAACAAGCA	0.557000													15	63					0	0	1	0	0
HCRTR2	3062	broad.mit.edu	37	6	55113494	55113494	+	Missense_Mutation	SNP	T	T	C			TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chr6:55113494T>C	ENST00000370862.3	+	2	617	c.281T>C	c.(280-282)gTc>gCc	p.V94A		NM_001526.3	NP_001517.2	O43614	OX2R_HUMAN	hypocretin (orexin) receptor 2	94					feeding behavior	integral to plasma membrane	neuropeptide receptor activity			breast(3)|endometrium(2)|kidney(1)|large_intestine(7)|lung(23)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	46	Lung NSC(77;0.107)|Renal(3;0.122)		LUSC - Lung squamous cell carcinoma(124;0.23)			TACTTCATAGTCAATCTTTCT	0.453000													44	130					0	0	1	0	0
LCE1B	353132	broad.mit.edu	37	1	152784945	152784945	+	Missense_Mutation	SNP	A	A	T			TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chr1:152784945A>T	ENST00000360090.3	+	1	499	c.23A>T	c.(22-24)cAg>cTg	p.Q8L		NM_178349.1	NP_848126.1	Q5T7P3	LCE1B_HUMAN	late cornified envelope 1B	8					keratinization					breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(5)|skin(2)	18	Lung NSC(65;9.06e-30)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.171)			CAGAACCAGCAGCAGTGCCAG	0.602000													80	130					0	0	1	0	0
NUP188	23511	broad.mit.edu	37	9	131760464	131760464	+	Missense_Mutation	SNP	G	G	A			TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chr9:131760464G>A	ENST00000372577.2	+	31	3407	c.3386G>A	c.(3385-3387)cGt>cAt	p.R1129H		NM_015354.1	NP_056169.1	Q5SRE5	NU188_HUMAN	nucleoporin 188kDa	1129					carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear pore	protein binding			breast(2)|central_nervous_system(3)|endometrium(6)|kidney(4)|large_intestine(9)|lung(20)|ovary(6)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	60						TCTGTGGTGCGTCGCCAGCTC	0.438000													36	228					0	0	1	0	0
GSTA5	221357	broad.mit.edu	37	6	52697743	52697743	+	Missense_Mutation	SNP	T	T	A			TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chr6:52697743T>A	ENST00000370989.1	-	6	618	c.460A>T	c.(460-462)Agc>Tgc	p.S154C	GSTA5_ENST00000475052.1_5'UTR|GSTA5_ENST00000284562.2_Missense_Mutation_p.S154C			Q7RTV2	GSTA5_HUMAN	glutathione S-transferase alpha 5	154	GST C-terminal.				glutathione metabolic process|xenobiotic metabolic process	cytosol	glutathione transferase activity			endometrium(3)|large_intestine(2)|lung(7)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	15	Lung NSC(77;0.0912)				Glutathione(DB00143)	TCAGCCCAGCTCAGCTTGTTG	0.512000													20	131					0	0	1	0	0
OVCH1	341350	broad.mit.edu	37	12	29598233	29598233	+	Missense_Mutation	SNP	G	G	T			TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chr12:29598233G>T	ENST00000318184.5	-	23	2858	c.2859C>A	c.(2857-2859)agC>agA	p.S953R	OVCH1-AS1_ENST00000551108.1_Intron|OVCH1-AS1_ENST00000549411.1_Intron	NM_183378.2	NP_899234.2	Q7RTY7	OVCH1_HUMAN	ovochymase 1	953	CUB 3.				proteolysis	extracellular region	metal ion binding|serine-type endopeptidase activity			NS(2)|breast(4)|central_nervous_system(3)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(15)|lung(43)|ovary(5)|pancreas(3)|prostate(2)|skin(1)|soft_tissue(1)|stomach(3)	92	Lung NSC(12;1.84e-09)|Acute lymphoblastic leukemia(23;0.00885)|all_hematologic(23;0.0155)					AGACAATATAGCTTATACCAA	0.358000													33	38					9.93527e-08	1.18546e-07	1	1	0
SYT13	57586	broad.mit.edu	37	11	45267950	45267950	+	Missense_Mutation	SNP	C	C	A			TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chr11:45267950C>A	ENST00000020926.3	-	5	1071	c.960G>T	c.(958-960)aaG>aaT	p.K320N		NM_001247987.1|NM_020826.2	NP_001234916.1|NP_065877.1	Q7L8C5	SYT13_HUMAN	synaptotagmin XIII	320	C2 2.					transport vesicle				breast(1)|large_intestine(3)|lung(16)|ovary(1)|skin(2)	23						CCAGGAGCTCCTTGGACTGGT	0.597000													42	78					6.1244e-12	8.63171e-12	1	1	0
FMNL3	91010	broad.mit.edu	37	12	50041554	50041554	+	Missense_Mutation	SNP	C	C	T			TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chr12:50041554C>T	ENST00000335154.5	-	23	2943	c.2710G>A	c.(2710-2712)Gag>Aag	p.E904K	FMNL3_ENST00000352151.5_Missense_Mutation_p.E853K|FMNL3_ENST00000293590.5_Missense_Mutation_p.E904K|FMNL3_ENST00000550488.1_Missense_Mutation_p.E903K	NM_175736.4	NP_783863.4	Q8IVF7	FMNL3_HUMAN	formin-like 3	904	FH2.				actin cytoskeleton organization		actin binding|Rho GTPase binding			breast(4)|endometrium(7)|kidney(2)|large_intestine(6)|lung(11)|ovary(2)|pancreas(2)|prostate(2)|skin(2)|stomach(1)	39						TTGGGACTCTCGCCAAAGTAG	0.517000													12	99					0	0	1	0	0
COL7A1	1294	broad.mit.edu	37	3	48629410	48629410	+	Silent	SNP	C	C	A			TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chr3:48629410C>A	ENST00000328333.8	-	10	1385	c.1278G>T	c.(1276-1278)ctG>ctT	p.L426L	COL7A1_ENST00000454817.1_Silent_p.L426L	NM_000094.3	NP_000085.1	Q02388	CO7A1_HUMAN	collagen, type VII, alpha 1	426	Fibronectin type-III 3.|Nonhelical region (NC1).				cell adhesion|epidermis development	basement membrane|collagen type VII	protein binding|serine-type endopeptidase inhibitor activity			NS(3)|breast(8)|central_nervous_system(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|lung(57)|ovary(7)|prostate(5)|skin(9)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(5)	137				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		ATGTGGGGCCCAGGATGACCG	0.662000													26	118					7.92952e-12	1.10278e-11	1	1	0
GABRA1	2554	broad.mit.edu	37	5	161324375	161324375	+	Missense_Mutation	SNP	G	G	T			TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chr5:161324375G>T	ENST00000428797.2	+	11	1673	c.1318G>T	c.(1318-1320)Gct>Tct	p.A440S	GABRA1_ENST00000437025.2_Missense_Mutation_p.A440S|GABRA1_ENST00000393943.4_Missense_Mutation_p.A440S|GABRA1_ENST00000023897.6_Missense_Mutation_p.A440S|GABRA1_ENST00000420560.1_Missense_Mutation_p.A440S|GABRA1_ENST00000444819.1_Missense_Mutation_p.A440S	NM_001127643.1	NP_001121115.1	P14867	GBRA1_HUMAN	gamma-aminobutyric acid (GABA) A receptor, alpha 1	440					gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			NS(1)|endometrium(2)|kidney(3)|large_intestine(4)|liver(1)|lung(22)|ovary(2)|pancreas(2)|prostate(1)|skin(3)|urinary_tract(1)	42	Renal(175;0.00259)	Medulloblastoma(196;0.0208)|all_neural(177;0.0672)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.228)	Alprazolam(DB00404)|Butabarbital(DB00237)|Butalbital(DB00241)|Butethal(DB01353)|Chlordiazepoxide(DB00475)|Clobazam(DB00349)|Clonazepam(DB01068)|Clorazepate(DB00628)|Desflurane(DB01189)|Diazepam(DB00829)|Enflurane(DB00228)|Ethanol(DB00898)|Ethchlorvynol(DB00189)|Etomidate(DB00292)|Flumazenil(DB01205)|Flurazepam(DB00690)|Halazepam(DB00801)|Halothane(DB01159)|Hexobarbital(DB01355)|Isoflurane(DB00753)|Lorazepam(DB00186)|Meprobamate(DB00371)|Metharbital(DB00463)|Methohexital(DB00474)|Methoxyflurane(DB01028)|Methylphenobarbital(DB00849)|Methyprylon(DB01107)|Midazolam(DB00683)|Nitrazepam(DB01595)|Oxazepam(DB00842)|Pentobarbital(DB00312)|Phenobarbital(DB01174)|Picrotoxin(DB00466)|Prazepam(DB01588)|Primidone(DB00794)|Progabide(DB00837)|Propofol(DB00818)|Quazepam(DB01589)|Secobarbital(DB00418)|Sevoflurane(DB01236)|Talbutal(DB00306)|Thiamylal(DB01154)|Thiopental(DB00599)|Topiramate(DB00273)|Zaleplon(DB00962)|Zolpidem(DB00425)	AGTCTACTGGGCTACGTATTT	0.423000													23	92					3.28513e-13	4.69304e-13	1	1	0
GIMAP4	55303	broad.mit.edu	37	7	150269446	150269446	+	Missense_Mutation	SNP	T	T	A			TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chr7:150269446T>A	ENST00000255945.2	+	3	463	c.288T>A	c.(286-288)aaT>aaA	p.N96K	GIMAP4_ENST00000461940.1_Missense_Mutation_p.N110K|GIMAP4_ENST00000494750.1_3'UTR	NM_018326.2	NP_060796.1	Q9NUV9	GIMA4_HUMAN	GTPase, IMAP family member 4	96							GTP binding			breast(1)|endometrium(1)|large_intestine(3)|lung(5)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	14			OV - Ovarian serous cystadenocarcinoma(82;0.0179)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		AGGTGCCCAATGCTGAAACGT	0.507000													26	45					0	0	1	0	0
SLC18A1	6570	broad.mit.edu	37	8	20036006	20036006	+	Splice_Site	SNP	T	T	A			TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chr8:20036006T>A	ENST00000440926.1	-	5	959		c.e5-2		SLC18A1_ENST00000437980.1_Splice_Site|SLC18A1_ENST00000381608.4_Splice_Site|SLC18A1_ENST00000265808.7_Splice_Site|SLC18A1_ENST00000519026.1_Splice_Site|SLC18A1_ENST00000276373.5_Splice_Site	NM_001135691.2	NP_001129163.1	P54219	VMAT1_HUMAN	solute carrier family 18 (vesicular monoamine transporter), member 1						neurotransmitter transport	clathrin sculpted monoamine transport vesicle membrane|integral to membrane|membrane fraction	drug transmembrane transporter activity|monoamine transmembrane transporter activity			central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(10)|ovary(3)|prostate(1)|upper_aerodigestive_tract(1)	29				Colorectal(74;0.0747)		TATCCAATCCTAAAAGGGAAT	0.358000													7	22					0	0	1	0	0
UGT1A3	54659	broad.mit.edu	37	2	234638492	234638492	+	Missense_Mutation	SNP	G	G	C			TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chr2:234638492G>C	ENST00000482026.1	+	1	739	c.720G>C	c.(718-720)caG>caC	p.Q240H	UGT1A6_ENST00000406651.1_Intron|UGT1A6_ENST00000373424.1_Intron|UGT1A7_ENST00000373426.3_Intron|UGT1A10_ENST00000373445.1_Intron|UGT1A8_ENST00000373450.4_Intron|UGT1A9_ENST00000354728.4_Intron|UGT1A10_ENST00000344644.5_Intron|UGT1A6_ENST00000305139.6_Intron|UGT1A4_ENST00000373409.3_Intron|UGT1A5_ENST00000373414.3_Intron|UGT1A6_ENST00000480628.1_Intron	NM_019093.2	NP_061966.1														breast(2)|endometrium(7)|kidney(18)|large_intestine(6)|lung(10)|ovary(1)|skin(1)|urinary_tract(1)	46		Breast(86;0.000765)|all_lung(227;0.00266)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0327)|Lung NSC(271;0.0456)|Lung SC(224;0.128)		Epithelial(121;2.4e-18)|BRCA - Breast invasive adenocarcinoma(100;0.000476)|Lung(119;0.00243)|LUSC - Lung squamous cell carcinoma(224;0.00599)		AGCTTTTTCAGAGAGAGGTGT	0.507000													124	172					0	0	1	0	0
APCS	325	broad.mit.edu	37	1	159558026	159558026	+	Missense_Mutation	SNP	G	G	T			TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chr1:159558026G>T	ENST00000255040.2	+	2	297	c.200G>T	c.(199-201)aGc>aTc	p.S67I		NM_001639.3	NP_001630.1	P02743	SAMP_HUMAN	amyloid P component, serum	67	Pentaxin.				acute-phase response|chaperone-mediated protein complex assembly|protein folding	extracellular space	metal ion binding|sugar binding|unfolded protein binding			breast(1)|endometrium(4)|kidney(1)|large_intestine(3)|lung(8)|ovary(1)|skin(2)	20	all_hematologic(112;0.0429)					CGTGCCTACAGCCTCTTCTCC	0.413000													37	99					4.62619e-21	7.30451e-21	1	1	0
NLRC3	197358	broad.mit.edu	37	16	3614256	3614256	+	RNA	SNP	G	G	A			TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chr16:3614256G>A	ENST00000301749.7	-	0	1087				NLRC3_ENST00000359128.5_RNA|NLRC3_ENST00000419350.2_RNA|NLRC3_ENST00000603507.1_RNA|NLRC3_ENST00000448023.2_RNA|NLRC3_ENST00000324659.8_RNA	NM_178844.2	NP_849172.2	Q7RTR2	NLRC3_HUMAN	NLR family, CARD domain containing 3						I-kappaB kinase/NF-kappaB cascade|negative regulation of NF-kappaB transcription factor activity|T cell activation	cytoplasm	ATP binding			breast(1)|central_nervous_system(2)|endometrium(1)|kidney(3)|large_intestine(1)|liver(1)|lung(16)|ovary(2)|pancreas(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	34						GAGAAGTCCAGAGGCGTCCTG	0.637000													6	27					0	0	1	0	0
SLC8A2	6543	broad.mit.edu	37	19	47935673	47935673	+	Silent	SNP	G	G	T			TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chr19:47935673G>T	ENST00000236877.6	-	9	2535	c.2140C>A	c.(2140-2142)Cgg>Agg	p.R714R	SLC8A2_ENST00000601757.1_5'UTR|SLC8A2_ENST00000542837.1_Silent_p.R470R|SLC8A2_ENST00000539381.1_Silent_p.R177R	NM_015063.2	NP_055878.1	Q9UPR5	NAC2_HUMAN	solute carrier family 8 (sodium/calcium exchanger), member 2	714					cell communication|platelet activation	integral to membrane|plasma membrane	calcium:sodium antiporter activity|calmodulin binding			breast(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(10)|ovary(2)|prostate(2)|skin(5)|stomach(1)	31		all_cancers(25;3.05e-07)|all_lung(116;4.19e-06)|Lung NSC(112;7.16e-06)|all_epithelial(76;7.65e-06)|all_neural(266;0.0652)|Ovarian(192;0.086)|Breast(70;0.173)		OV - Ovarian serous cystadenocarcinoma(262;0.000501)|all cancers(93;0.00058)|Epithelial(262;0.0181)|GBM - Glioblastoma multiforme(486;0.0457)		CGCTCCTCCCGGGACCCGTCC	0.622000													25	104					1.16021e-09	1.47663e-09	1	1	0
GALNT14	79623	broad.mit.edu	37	2	31167808	31167808	+	Splice_Site	SNP	C	C	A			TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chr2:31167808C>A	ENST00000349752.5	-	8	1382	c.742_splice	c.e8-1	p.G248_splice	GALNT14_ENST00000406653.1_Splice_Site_p.G228_splice|GALNT14_ENST00000356174.3_Splice_Site_p.G215_splice|GALNT14_ENST00000324589.5_Splice_Site_p.G253_splice|GALNT14_ENST00000420311.2_Splice_Site_p.G213_splice|GALNT14_ENST00000486564.1_5'UTR	NM_024572.3	NP_078848.2	Q96FL9	GLT14_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 14 (GalNAc-T14)	248						Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			cervix(1)|endometrium(3)|large_intestine(10)|liver(1)|lung(21)|ovary(1)|skin(3)|upper_aerodigestive_tract(3)	43	Acute lymphoblastic leukemia(172;0.155)					CCAGTCAAACCCTACAACACA	0.577000													39	40					1.07121e-22	1.7172e-22	1	1	0
SPTBN1	6711	broad.mit.edu	37	2	54876169	54876169	+	Missense_Mutation	SNP	G	G	A			TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chr2:54876169G>A	ENST00000333896.5	+	24	5390	c.5005G>A	c.(5005-5007)Ggt>Agt	p.G1669S	SPTBN1_ENST00000356805.4_Missense_Mutation_p.G1682S	NM_178313.2	NP_842565.2	Q01082	SPTB2_HUMAN	spectrin, beta, non-erythrocytic 1	1682	Interaction with ANK2.				actin filament capping|axon guidance	cytosol|nucleolus|plasma membrane|sarcomere|spectrin	actin binding|calmodulin binding|protein binding|structural constituent of cytoskeleton			NS(1)|breast(8)|central_nervous_system(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(11)|lung(27)|ovary(4)|prostate(2)|skin(5)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	82			Lung(47;0.24)			ACTGTACGCTGGTCTGAAAGA	0.488000													28	37					0	0	1	0	0
CPA2	1358	broad.mit.edu	37	7	129915048	129915048	+	Missense_Mutation	SNP	G	G	T			TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chr7:129915048G>T	ENST00000222481.4	+	6	601	c.546G>T	c.(544-546)gaG>gaT	p.E182D		NM_001869.2	NP_001860.2	P48052	CBPA2_HUMAN	carboxypeptidase A2 (pancreatic)	182	Substrate binding (By similarity).				proteolysis|vacuolar protein catabolic process	extracellular region|vacuole	metallocarboxypeptidase activity|zinc ion binding			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(6)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	14	Melanoma(18;0.0435)					ATGCTCGAGAGTGGGTTACAC	0.512000													10	51					1.58986e-06	1.84459e-06	1	1	0
COQ2	27235	broad.mit.edu	37	4	84191124	84191124	+	Silent	SNP	C	C	A			TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chr4:84191124C>A	ENST00000311469.4	-	5	800	c.801G>T	c.(799-801)gcG>gcT	p.A267A	COQ2_ENST00000311461.7_Silent_p.A217A|COQ2_ENST00000439031.2_Silent_p.A230A	NM_015697.7	NP_056512.5	Q96H96	COQ2_HUMAN	coenzyme Q2 4-hydroxybenzoate polyprenyltransferase	217					glycerol metabolic process|isoprenoid biosynthetic process|ubiquinone biosynthetic process	mitochondrial membrane	4-hydroxybenzoate decaprenyltransferase activity|4-hydroxybenzoate nonaprenyltransferase activity			central_nervous_system(1)|endometrium(1)|large_intestine(3)|ovary(1)|skin(1)|stomach(1)	8		Hepatocellular(203;0.114)				ATCCAAGTAACGCTCCCCAAT	0.403000													17	74					1.15919e-05	1.32298e-05	1	1	0
NRCAM	4897	broad.mit.edu	37	7	107848037	107848037	+	Missense_Mutation	SNP	A	A	G			TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chr7:107848037A>G	ENST00000379028.3	-	13	1612	c.1142T>C	c.(1141-1143)aTc>aCc	p.I381T	NRCAM_ENST00000425651.2_Missense_Mutation_p.I381T|NRCAM_ENST00000379024.4_Missense_Mutation_p.I362T|NRCAM_ENST00000379022.4_Missense_Mutation_p.I381T|NRCAM_ENST00000413765.2_Missense_Mutation_p.I362T|NRCAM_ENST00000351718.4_Missense_Mutation_p.I375T			Q92823	NRCAM_HUMAN	neuronal cell adhesion molecule	381	Ig-like 4.				angiogenesis|axon guidance|axonal fasciculation|cell-cell adhesion|central nervous system development|clustering of voltage-gated sodium channels|neuron migration|positive regulation of neuron differentiation|regulation of axon extension|synapse assembly	external side of plasma membrane|integral to plasma membrane	ankyrin binding			breast(4)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(8)|liver(1)|lung(36)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(4)	65						AGCTCTGCAGATCAAGGTCCC	0.448000													5	61					0	0	1	0	0
CPED1	79974	broad.mit.edu	37	7	120906325	120906325	+	Silent	SNP	T	T	C			TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chr7:120906325T>C	ENST00000310396.5	+	19	2822	c.2355T>C	c.(2353-2355)taT>taC	p.Y785Y		NM_024913.4	NP_079189.4			cadherin-like and PC-esterase domain containing 1																		TCATGTACTATCTTATTGAAA	0.363000													26	108					0	0	1	0	0
EDIL3	10085	broad.mit.edu	37	5	83433159	83433159	+	Silent	SNP	G	G	A			TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chr5:83433159G>A	ENST00000296591.5	-	5	787	c.369C>T	c.(367-369)tgC>tgT	p.C123C	EDIL3_ENST00000380138.3_Silent_p.C113C	NM_005711.3	NP_005702.3	O43854	EDIL3_HUMAN	EGF-like repeats and discoidin I-like domains 3	123	EGF-like 3.				cell adhesion|multicellular organismal development	extracellular region	calcium ion binding|integrin binding			cervix(1)|endometrium(2)|kidney(3)|large_intestine(6)|lung(10)|ovary(1)|prostate(5)|skin(3)	31		Lung NSC(167;0.000121)|all_lung(232;0.000154)|Ovarian(174;0.0425)		OV - Ovarian serous cystadenocarcinoma(54;4.3e-40)|Epithelial(54;4.79e-32)|all cancers(79;1.54e-26)		GCTCAACTTCGCATTCATTTA	0.333000													13	80					0	0	1	0	0
AK9	221264	broad.mit.edu	37	6	109954298	109954298	+	Missense_Mutation	SNP	C	C	A			TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chr6:109954298C>A	ENST00000424296.2	-	12	1158	c.1082G>T	c.(1081-1083)gGt>gTt	p.G361V	AK9_ENST00000341338.6_5'UTR|AK9_ENST00000368948.2_Missense_Mutation_p.G361V|AK9_ENST00000285397.5_Missense_Mutation_p.G361V	NM_001145128.2	NP_001138600.2			adenylate kinase 9																		GTAGATTTTACCTAGAAAACT	0.333000													6	20					3.59834e-05	3.97711e-05	1	1	0
OR51A7	119687	broad.mit.edu	37	11	4929530	4929530	+	Missense_Mutation	SNP	G	G	T			TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chr11:4929530G>T	ENST00000359350.4	+	1	931	c.931G>T	c.(931-933)Ggg>Tgg	p.G311W	MMP26_ENST00000380390.1_Intron|MMP26_ENST00000477339.1_Intron	NM_001004749.1	NP_001004749.1	Q8NH64	O51A7_HUMAN	olfactory receptor, family 51, subfamily A, member 7	311					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.G311W(1)		breast(1)|endometrium(1)|large_intestine(7)|lung(13)|ovary(1)|skin(4)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	33		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;4.77e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00435)|LUSC - Lung squamous cell carcinoma(625;0.19)		TAATGTATGTGGGAGATAAGA	0.393000													33	36					2.80507e-11	3.75201e-11	1	1	0
PRB2	653247	broad.mit.edu	37	12	11546672	11546672	+	Missense_Mutation	SNP	G	G	T			TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chr12:11546672G>T	ENST00000389362.4	-	3	375	c.340C>A	c.(340-342)Cct>Act	p.P114T	PRB1_ENST00000546254.1_Intron	NM_006248.3	NP_006239.3			proline-rich protein BstNI subfamily 2											NS(1)|breast(1)|endometrium(2)|kidney(3)|large_intestine(3)|lung(14)|pancreas(1)|prostate(5)|skin(4)|stomach(2)|urinary_tract(1)	37		all_cancers(2;0.00558)|Acute lymphoblastic leukemia(2;3.94e-11)|all_hematologic(2;3.6e-09)	OV - Ovarian serous cystadenocarcinoma(49;0.185)			TTTCCTGGAGGAGATCGGGGA	0.612000													110	874					2.28164e-27	3.74332e-27	1	1	0
SACS	26278	broad.mit.edu	37	13	23908556	23908556	+	Missense_Mutation	SNP	C	C	A			TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chr13:23908556C>A	ENST00000382298.3	-	10	10047	c.9459G>T	c.(9457-9459)ttG>ttT	p.L3153F	SACS_ENST00000402364.1_Missense_Mutation_p.L2403F|SACS_ENST00000382292.3_Missense_Mutation_p.L3153F	NM_014363.4	NP_055178.3	Q9NZJ4	SACS_HUMAN	spastic ataxia of Charlevoix-Saguenay (sacsin)	3153					cell death|negative regulation of inclusion body assembly|protein folding	axon|cell body fiber|dendrite|mitochondrion|nucleus	ATP binding|chaperone binding|Hsp70 protein binding|proteasome binding			NS(1)|biliary_tract(1)|breast(3)|central_nervous_system(2)|endometrium(22)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(54)|lung(49)|ovary(7)|pancreas(1)|prostate(4)|skin(10)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(11)	189		all_cancers(29;1.51e-22)|all_epithelial(30;7.82e-19)|all_lung(29;4.71e-18)|Lung SC(185;0.0225)|Breast(139;0.128)		all cancers(112;0.00197)|Epithelial(112;0.00854)|OV - Ovarian serous cystadenocarcinoma(117;0.0298)|Lung(94;0.189)		TGAGAAGGGGCAATCCCTCAA	0.353000													6	13					0.0215528	0.0218651	1	1	0
KLK9	284366	broad.mit.edu	37	19	51506412	51506412	+	Missense_Mutation	SNP	G	G	C			TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chr19:51506412G>C	ENST00000376832.4	-	5	741	c.708C>G	c.(706-708)agC>agG	p.S236R	KLK9_ENST00000594211.1_Missense_Mutation_p.S236R|KLK9_ENST00000250366.6_Missense_Mutation_p.S236R|CTB-147C22.9_ENST00000594512.1_RNA	NM_012315.1	NP_036447.1	Q9UKQ9	KLK9_HUMAN	kallikrein-related peptidase 9	236	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(3)|skin(1)	7		all_neural(266;0.0652)		OV - Ovarian serous cystadenocarcinoma(262;0.00328)|GBM - Glioblastoma multiforme(134;0.00885)		AGTGGCATACGCTGGTGTAGA	0.647000													9	171					0	0	1	0	0
NPAP1	23742	broad.mit.edu	37	15	24921285	24921285	+	Missense_Mutation	SNP	G	G	C			TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chr15:24921285G>C	ENST00000329468.2	+	1	745	c.271G>C	c.(271-273)Ggg>Cgg	p.G91R		NM_018958.2	NP_061831.2			nuclear pore associated protein 1																		TGTGGGTTGGGGGCTGGCCAT	0.672000													15	49					0	0	1	0	0
ZNF677	342926	broad.mit.edu	37	19	53741171	53741171	+	Missense_Mutation	SNP	T	T	A			TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chr19:53741171T>A	ENST00000333952.4	-	5	974	c.809A>T	c.(808-810)aAg>aTg	p.K270M	ZNF677_ENST00000598513.1_Missense_Mutation_p.K270M			Q86XU0	ZN677_HUMAN	zinc finger protein 677	270					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(13)|lung(6)|ovary(1)|pancreas(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	36				GBM - Glioblastoma multiforme(134;0.00352)		GCTAAAAGCCTTTCCACAGTC	0.358000													6	43					0	0	1	0	0
COL11A1	1301	broad.mit.edu	37	1	103471662	103471662	+	Missense_Mutation	SNP	C	C	T			TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chr1:103471662C>T	ENST00000358392.2	-	17	2106	c.1789G>A	c.(1789-1791)Gat>Aat	p.D597N	COL11A1_ENST00000370096.3_Missense_Mutation_p.D585N|COL11A1_ENST00000353414.4_Missense_Mutation_p.D546N|COL11A1_ENST00000461720.1_5'UTR|COL11A1_ENST00000512756.1_Missense_Mutation_p.D469N	NM_080629.2	NP_542196.2	P12107	COBA1_HUMAN	collagen, type XI, alpha 1	585	Triple-helical region.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			NS(3)|biliary_tract(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(17)|kidney(8)|large_intestine(28)|lung(157)|ovary(6)|pancreas(2)|prostate(6)|skin(9)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(1)	258		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		CTTCCTCCATCTGCACCTGGA	0.363000													26	27					0	0	1	0	0
CLASP1	23332	broad.mit.edu	37	2	122154724	122154724	+	Missense_Mutation	SNP	C	C	G			TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chr2:122154724C>G	ENST00000263710.4	-	30	3504	c.3115G>C	c.(3115-3117)Gtg>Ctg	p.V1039L	CLASP1_ENST00000541859.1_Missense_Mutation_p.V795L|CLASP1_ENST00000541377.1_Missense_Mutation_p.V1017L|CLASP1_ENST00000545861.1_Missense_Mutation_p.V785L|CLASP1_ENST00000397587.3_Missense_Mutation_p.V1018L|CLASP1_ENST00000455322.2_Missense_Mutation_p.V1034L|CLASP1_ENST00000409078.3_Missense_Mutation_p.V1011L	NM_015282.2	NP_056097.1	Q7Z460	CLAP1_HUMAN	cytoplasmic linker associated protein 1	1039					axon guidance|cell division|establishment or maintenance of cell polarity|exit from mitosis|G2/M transition of mitotic cell cycle|microtubule anchoring|microtubule bundle formation|microtubule nucleation|microtubule organizing center organization|mitotic prometaphase|negative regulation of microtubule depolymerization	centrosomal corona|condensed chromosome kinetochore|cortical microtubule cytoskeleton|cytoplasmic microtubule|cytosol|Golgi apparatus|kinetochore microtubule	kinetochore binding|microtubule plus-end binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(8)|kidney(4)|large_intestine(8)|lung(19)|ovary(1)|prostate(1)	47	Renal(3;0.0496)					ACCTTTCTCACGTCTGAACTC	0.428000													7	45					0	0	1	0	0
ANK2	287	broad.mit.edu	37	4	114163317	114163317	+	Missense_Mutation	SNP	G	G	T			TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chr4:114163317G>T	ENST00000357077.4	+	9	896	c.843G>T	c.(841-843)atG>atT	p.M281I	ANK2_ENST00000506722.1_Missense_Mutation_p.M260I|ANK2_ENST00000264366.6_Missense_Mutation_p.M281I|ANK2_ENST00000394537.3_Missense_Mutation_p.M281I	NM_001148.4	NP_001139.3	Q01484	ANK2_HUMAN	ankyrin 2, neuronal	281					axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding			NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(10)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(54)|liver(2)|lung(112)|ovary(8)|pancreas(1)|prostate(7)|skin(11)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(10)	248		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		ATACAAACATGGTGAAGCTCT	0.433000													7	70					8.12818e-05	8.75343e-05	1	1	0
TAL1	6886	broad.mit.edu	37	1	47685462	47685462	+	Missense_Mutation	SNP	G	G	T			TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chr1:47685462G>T	ENST00000371883.3	-	4	1508	c.932C>A	c.(931-933)gCg>gAg	p.A311E	TAL1_ENST00000294339.3_Missense_Mutation_p.A309E|TAL1_ENST00000371884.2_Missense_Mutation_p.A309E|TAL1_ENST00000459729.1_5'UTR			P17542	TAL1_HUMAN	T-cell acute lymphocytic leukemia 1	309					basophil differentiation|cell fate commitment|cell proliferation|embryonic hemopoiesis|erythrocyte differentiation|megakaryocyte differentiation|positive regulation of cell division|positive regulation of chromatin assembly or disassembly|positive regulation of erythrocyte differentiation|positive regulation of mitotic cell cycle|positive regulation of protein complex assembly|positive regulation of transcription from RNA polymerase II promoter	nuclear chromatin	E-box binding|histone deacetylase binding|sequence-specific DNA binding transcription factor activity			haematopoietic_and_lymphoid_tissue(1)|lung(12)|prostate(1)|upper_aerodigestive_tract(1)	15						GTGTTTGGGCGCGGGCTCCTC	0.692000			T	"""TRD@, SIL"""	lymphoblastic leukemia/biphasic								26	89					6.12954e-19	9.39564e-19	1	1	0
DYNC1I1	1780	broad.mit.edu	37	7	95499293	95499293	+	Missense_Mutation	SNP	C	C	A			TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chr7:95499293C>A	ENST00000324972.6	+	6	717	c.524C>A	c.(523-525)gCc>gAc	p.A175D	DYNC1I1_ENST00000359388.4_Missense_Mutation_p.A138D|DYNC1I1_ENST00000447467.2_Missense_Mutation_p.A158D|DYNC1I1_ENST00000437599.1_Missense_Mutation_p.A155D|DYNC1I1_ENST00000457059.1_Missense_Mutation_p.A158D|DYNC1I1_ENST00000537881.1_Missense_Mutation_p.A138D	NM_004411.4	NP_004402.1	O14576	DC1I1_HUMAN	dynein, cytoplasmic 1, intermediate chain 1	175					vesicle transport along microtubule	condensed chromosome kinetochore|cytoplasmic dynein complex|microtubule|perinuclear region of cytoplasm|spindle pole|vesicle	microtubule binding|microtubule motor activity			NS(2)|autonomic_ganglia(1)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(10)|lung(27)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	54	all_cancers(62;9.39e-10)|all_epithelial(64;2.28e-09)|Lung NSC(181;0.165)|all_lung(186;0.191)		STAD - Stomach adenocarcinoma(171;0.0957)			ACTCCTCTTGCCACGCATCAG	0.448000													9	55					0.00448238	0.00463695	1	1	0
OR14A16	284532	broad.mit.edu	37	1	247978419	247978419	+	Missense_Mutation	SNP	C	C	A			TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chr1:247978419C>A	ENST00000357627.1	-	1	612	c.613G>T	c.(613-615)Gat>Tat	p.D205Y		NM_001001966.1	NP_001001966.1	Q8NHC5	O14AG_HUMAN	olfactory receptor, family 14, subfamily A, member 16	205					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(5)|kidney(1)|large_intestine(3)|lung(32)|skin(2)|stomach(1)	45						CAGCAGAAATCCAAAACTACA	0.378000													13	87					2.27111e-07	2.6794e-07	1	1	0
FERD3L	222894	broad.mit.edu	37	7	19184573	19184573	+	Missense_Mutation	SNP	G	G	T			TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chr7:19184573G>T	ENST00000275461.3	-	1	471	c.413C>A	c.(412-414)tCc>tAc	p.S138Y	AC003986.5_ENST00000452700.1_RNA	NM_152898.2	NP_690862.1	Q96RJ6	FER3L_HUMAN	Fer3-like bHLH transcription factor	138	Helix-loop-helix motif.				negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			breast(1)|endometrium(4)|large_intestine(8)|lung(16)|ovary(1)|prostate(2)|skin(1)|urinary_tract(2)	35						CTCGATCCGGGACAGCCTTTT	0.577000													8	73					0.0581538	0.058432	1	1	0
OR4A16	81327	broad.mit.edu	37	11	55111418	55111418	+	Missense_Mutation	SNP	G	G	T	rs141537673		TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chr11:55111418G>T	ENST00000314721.2	+	1	792	c.742G>T	c.(742-744)Gtt>Ttt	p.V248F		NM_001005274.1	NP_001005274.1	Q8NH70	O4A16_HUMAN	olfactory receptor, family 4, subfamily A, member 16	248					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(28)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	51						GGTTGCCCTCGTTTTTGTTCC	0.398000													33	36					8.16721e-17	1.23389e-16	1	1	0
ARHGAP24	83478	broad.mit.edu	37	4	86643125	86643125	+	Splice_Site	SNP	G	G	A			TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chr4:86643125G>A	ENST00000395184.1	+	3	734	c.268_splice	c.e3+1	p.G90_splice	ARHGAP24_ENST00000503995.1_Splice_Site_p.G90_splice|ARHGAP24_ENST00000506421.1_3'UTR	NM_001025616.2	NP_001020787.2	Q8N264	RHG24_HUMAN	Rho GTPase activating protein 24	90	PH.				angiogenesis|cell differentiation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cell projection|cytoskeleton|cytosol|focal adhesion	GTPase activator activity|protein binding			breast(3)|cervix(1)|endometrium(3)|large_intestine(4)|lung(10)|skin(1)|stomach(1)|urinary_tract(1)	24		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.242)		OV - Ovarian serous cystadenocarcinoma(123;0.000571)		AGTAGTTCCAGGTAAGATATT	0.378000													4	24					0	0	1	0	0
HSPBP1	23640	broad.mit.edu	37	19	55776713	55776713	+	Missense_Mutation	SNP	G	G	A			TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chr19:55776713G>A	ENST00000255631.5	-	8	1248	c.938C>T	c.(937-939)cCg>cTg	p.P313L	HSPBP1_ENST00000376343.3_Missense_Mutation_p.P211L|HSPBP1_ENST00000433386.2_Missense_Mutation_p.P313L|HSPBP1_ENST00000587922.1_Missense_Mutation_p.P313L	NM_001130106.1|NM_012267.4	NP_001123578.1|NP_036399.3	Q9NZL4	HPBP1_HUMAN	HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1	316					positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein ubiquitination|protein folding		enzyme inhibitor activity|protein binding			endometrium(1)|kidney(1)|large_intestine(2)|lung(2)|prostate(1)|urinary_tract(1)	8			BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0452)		GCCCAGTTCCGGCTCCCGACA	0.652000													39	133					0	0	1	0	0
TYW1B	441250	broad.mit.edu	37	7	72193901	72193901	+	RNA	SNP	T	T	A			TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chr7:72193901T>A	ENST00000438125.1	-	0	696							Q6NUM6	TYW1B_HUMAN	tRNA-yW synthesizing protein 1 homolog B (S. cerevisiae)						tRNA processing		4 iron, 4 sulfur cluster binding|FMN binding|iron ion binding|oxidoreductase activity										TTGTGGTGCCTAGGAACAAGA	0.408000													3	22					0	0	1	0	0
SMCHD1	23347	broad.mit.edu	37	18	2688676	2688676	+	Silent	SNP	T	T	G			TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chr18:2688676T>G	ENST00000320876.6	+	7	1142	c.804T>G	c.(802-804)tcT>tcG	p.S268S	RP11-703M24.5_ENST00000583546.1_RNA|SMCHD1_ENST00000261598.8_Silent_p.S268S	NM_015295.2	NP_056110.2	A6NHR9	SMHD1_HUMAN	structural maintenance of chromosomes flexible hinge domain containing 1	268					chromosome organization		ATP binding			NS(3)|breast(3)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(16)|lung(15)|pancreas(1)	45						TTGTGCTTTCTAAAGAAGATT	0.279000													3	6					0	0	1	0	0
DOCK2	1794	broad.mit.edu	37	5	169141194	169141194	+	Missense_Mutation	SNP	T	T	C			TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chr5:169141194T>C	ENST00000256935.8	+	18	1902	c.1822T>C	c.(1822-1824)Tcc>Ccc	p.S608P	DOCK2_ENST00000540750.1_5'UTR|DOCK2_ENST00000520908.1_Missense_Mutation_p.S100P	NM_004946.2	NP_004937.1	Q92608	DOCK2_HUMAN	dedicator of cytokinesis 2	608	DHR-1.				actin cytoskeleton organization|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|endomembrane system|membrane	electron carrier activity|GTP binding|GTPase binding|heme binding|Rac guanyl-nucleotide exchange factor activity|T cell receptor binding			NS(2)|breast(5)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(42)|liver(2)|lung(63)|ovary(5)|pancreas(3)|prostate(7)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)	160	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			CCTGGTGTGCTCCACAAAGCT	0.542000													14	46					0	0	1	0	0
LDOC1	23641	broad.mit.edu	37	X	140271177	140271177	+	Missense_Mutation	SNP	G	G	T			TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chrX:140271177G>T	ENST00000370526.2	-	1	133	c.30C>A	c.(28-30)caC>caA	p.H10Q	LDOC1_ENST00000460721.1_5'UTR	NM_012317.2	NP_036449.1	O95751	LDOC1_HUMAN	leucine zipper, down-regulated in cancer 1	10					negative regulation of cell proliferation	nucleus	protein binding			endometrium(6)|large_intestine(1)|lung(6)|ovary(1)	14	Acute lymphoblastic leukemia(192;7.65e-05)					TCAGGAGCGCGTGCAGCAGCA	0.677000													11	9					1.49906e-05	1.68344e-05	1	1	0
MTERF	7978	broad.mit.edu	37	7	91503720	91503720	+	Nonsense_Mutation	SNP	G	G	A			TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chr7:91503720G>A	ENST00000419292.1	-	2	404	c.328C>T	c.(328-330)Cga>Tga	p.R110*	CTB-104F4.2_ENST00000454222.1_RNA|MTERF_ENST00000351870.3_Nonsense_Mutation_p.R130*|MTERF_ENST00000406735.2_Nonsense_Mutation_p.R110*			Q99551	MTERF_HUMAN	mitochondrial transcription termination factor	130					DNA geometric change|regulation of transcription, DNA-dependent|termination of mitochondrial transcription	mitochondrial nucleoid	double-stranded DNA binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(4)|liver(1)|lung(2)|skin(1)	14	all_cancers(62;2.28e-09)|all_epithelial(64;1.07e-07)|Breast(17;0.00371)|all_hematologic(106;0.091)|all_lung(186;0.178)|Lung NSC(181;0.235)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.0993)|Kidney(17;0.118)|Epithelial(20;0.136)|LUSC - Lung squamous cell carcinoma(200;0.176)			GTTATTGCTCGTGGATATCTT	0.403000													72	75					0	0	1	0	0
FAM135B	51059	broad.mit.edu	37	8	139165449	139165449	+	Silent	SNP	C	C	T			TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chr8:139165449C>T	ENST00000395297.1	-	13	1439	c.1269G>A	c.(1267-1269)ttG>ttA	p.L423L		NM_015912.3	NP_056996.2	Q49AJ0	F135B_HUMAN	family with sequence similarity 135, member B	423										NS(3)|breast(9)|endometrium(21)|kidney(5)|large_intestine(28)|liver(1)|lung(135)|ovary(9)|pancreas(1)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(1)	238	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			GATAAACACTCAAGTTATGCC	0.269000										HNSCC(54;0.14)			7	21					0	0	1	0	0
NCOA5	57727	broad.mit.edu	37	20	44691222	44691222	+	Missense_Mutation	SNP	C	C	T			TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chr20:44691222C>T	ENST00000290231.6	-	8	1621	c.1457G>A	c.(1456-1458)aGc>aAc	p.S486N		NM_020967.2	NP_066018.1	Q9HCD5	NCOA5_HUMAN	nuclear receptor coactivator 5	486	Transcription activation.				regulation of transcription, DNA-dependent|transcription, DNA-dependent|translation	nucleus	aminoacyl-tRNA ligase activity|ATP binding			central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(5)|liver(1)|lung(5)|ovary(1)|skin(2)|urinary_tract(1)	21		Myeloproliferative disorder(115;0.0122)				TCCCAAAATGCTTGGAGGCTG	0.572000													30	104					0	0	1	0	0
VIPR1	7433	broad.mit.edu	37	3	42572424	42572424	+	Splice_Site	SNP	G	G	T			TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chr3:42572424G>T	ENST00000433647.1	+	8	1291	c.667_splice	c.e8+1	p.G223_splice	VIPR1-AS1_ENST00000452639.2_RNA|VIPR1-AS1_ENST00000601312.1_RNA|VIPR1_ENST00000438259.2_Intron|VIPR1-AS1_ENST00000598837.1_RNA|VIPR1-AS1_ENST00000596630.1_RNA|VIPR1-AS1_ENST00000593611.1_RNA|VIPR1-AS1_ENST00000593621.1_RNA|VIPR1_ENST00000325123.4_Splice_Site_p.G264_splice|VIPR1_ENST00000543411.1_Splice_Site_p.G216_splice|VIPR1-AS1_ENST00000600342.1_RNA|VIPR1-AS1_ENST00000602176.1_RNA	NM_001251882.1	NP_001238811.1	P32241	VIPR1_HUMAN	vasoactive intestinal peptide receptor 1	264					digestion|G-protein signaling, coupled to cyclic nucleotide second messenger|immune response|muscle contraction|positive regulation of cell proliferation|synaptic transmission	integral to plasma membrane	vasoactive intestinal polypeptide receptor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|ovary(2)|skin(1)|urinary_tract(3)	18				KIRC - Kidney renal clear cell carcinoma(284;0.241)		CATCGGCTGGGGTATGGTACC	0.612000													14	75					1.3612e-06	1.58807e-06	1	1	0
MAML3	55534	broad.mit.edu	37	4	140811099	140811099	+	Splice_Site	SNP	C	C	T			TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chr4:140811099C>T	ENST00000398940.1	-	1	107	c.108_splice	c.e1+1	p.Q36_splice	MAML3_ENST00000327122.5_Silent_p.Q341Q|MAML3_ENST00000509479.2_Silent_p.Q497Q			Q96JK9	MAML3_HUMAN	mastermind-like 3 (Drosophila)	497					Notch signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear speck	transcription coactivator activity	p.Q497Q(2)		breast(1)|endometrium(7)|kidney(2)|large_intestine(1)|lung(9)|ovary(1)|prostate(2)|urinary_tract(2)	25	all_hematologic(180;0.162)					gctgctgctgctgctgctgct	0.542000													4	51					0	0	1	0	0
FAM102A	399665	broad.mit.edu	37	9	130712919	130712919	+	Translation_Start_Site	SNP	G	G	T			TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chr9:130712919G>T	ENST00000373084.4	-	0	82				FAM102A_ENST00000373095.1_Intron|FAM102A_ENST00000300434.3_5'UTR	NM_203305.2	NP_976050.1	Q5T9C2	F102A_HUMAN	family with sequence similarity 102, member A											breast(1)|cervix(1)|large_intestine(3)|lung(1)|ovary(4)	10						GAGGGAGACAGATAAAGCCCC	0.617000													10	18					3.86212e-05	4.24631e-05	1	1	0
NLRP7	199713	broad.mit.edu	37	19	55450939	55450939	+	Missense_Mutation	SNP	G	G	T			TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chr19:55450939G>T	ENST00000588756.1	-	6	1734	c.1248C>A	c.(1246-1248)agC>agA	p.S416R	NLRP7_ENST00000328092.5_Missense_Mutation_p.S416R|NLRP7_ENST00000592784.1_Missense_Mutation_p.S416R|NLRP7_ENST00000448121.2_Missense_Mutation_p.S416R|NLRP7_ENST00000590030.1_Missense_Mutation_p.S416R|NLRP7_ENST00000446217.1_Missense_Mutation_p.S444R|NLRP7_ENST00000340844.2_Missense_Mutation_p.S416R			Q8WX94	NALP7_HUMAN	NLR family, pyrin domain containing 7	416	NACHT.						ATP binding			autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(17)|liver(1)|lung(33)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	73				GBM - Glioblastoma multiforme(193;0.0325)		CGGCCAGGAGGCTCAGCGTCC	0.711000													9	28					0.00448238	0.00463695	1	1	0
TP73-AS1	57212	broad.mit.edu	37	1	3662326	3662326	+	RNA	SNP	G	G	A			TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chr1:3662326G>A	ENST00000452079.1	-	0	1560				TP73-AS1_ENST00000423764.1_RNA|TP73-AS1_ENST00000544565.1_RNA|TP73-AS1_ENST00000418088.1_RNA	NR_033711.1																						CTCTGCAGCAGTGCCGGGCTC	0.632000													16	17					0	0	1	0	0
ENAM	10117	broad.mit.edu	37	4	71510249	71510249	+	Missense_Mutation	SNP	C	C	A			TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chr4:71510249C>A	ENST00000396073.3	+	9	3387	c.3106C>A	c.(3106-3108)Caa>Aaa	p.Q1036K	ENAM_ENST00000472903.1_Intron	NM_031889.2	NP_114095.2	Q9NRM1	ENAM_HUMAN	enamelin	1036					bone mineralization|odontogenesis	proteinaceous extracellular matrix	structural constituent of tooth enamel			haematopoietic_and_lymphoid_tissue(1)|ovary(3)|upper_aerodigestive_tract(2)	6			Lung(101;0.235)			CATCCAAAGTCAAGTCCAAGA	0.443000													35	57					7.11191e-15	1.05922e-14	1	1	0
LRP1	4035	broad.mit.edu	37	12	57577283	57577283	+	Missense_Mutation	SNP	C	C	A			TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chr12:57577283C>A	ENST00000243077.3	+	35	6250	c.5784C>A	c.(5782-5784)gaC>gaA	p.D1928E		NM_002332.2	NP_002323.2	Q07954	LRP1_HUMAN	low density lipoprotein receptor-related protein 1	1928					aorta morphogenesis|apoptotic cell clearance|negative regulation of platelet-derived growth factor receptor-beta signaling pathway|negative regulation of smooth muscle cell migration|negative regulation of Wnt receptor signaling pathway|positive regulation of cholesterol efflux|regulation of actin cytoskeleton organization|regulation of phospholipase A2 activity	coated pit|integral to plasma membrane|nucleus	apolipoprotein E binding|calcium ion binding|lipoprotein transporter activity|protein complex binding|receptor activity			NS(1)|breast(9)|central_nervous_system(3)|cervix(3)|endometrium(33)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(26)|lung(58)|ovary(10)|pancreas(2)|prostate(11)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(5)	184				BRCA - Breast invasive adenocarcinoma(357;0.0103)	Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Becaplermin(DB00102)|Coagulation Factor IX(DB00100)|Tenecteplase(DB00031)	TCGGCATCGACTTCCACGCTG	0.612000													9	26					1.12685e-05	1.29311e-05	1	1	0
ZNF184	7738	broad.mit.edu	37	6	27425103	27425103	+	Missense_Mutation	SNP	C	C	A			TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chr6:27425103C>A	ENST00000211936.6	-	4	445	c.161G>T	c.(160-162)aGg>aTg	p.R54M	ZNF184_ENST00000377419.1_Missense_Mutation_p.R54M	NM_007149.2	NP_009080.2	Q99676	ZN184_HUMAN	zinc finger protein 184	54	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|cervix(1)|endometrium(4)|kidney(9)|large_intestine(13)|lung(14)|ovary(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	48						TGTCACATCCCTGAACAAATC	0.443000													45	57					7.05121e-23	1.13904e-22	1	1	0
NPR3	4883	broad.mit.edu	37	5	32784903	32784903	+	Splice_Site	SNP	A	A	T			TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chr5:32784903A>T	ENST00000265074.8	+	7	1771	c.1426_splice	c.e7-1	p.S476_splice	NPR3_ENST00000415167.2_Splice_Site|NPR3_ENST00000434067.2_Splice_Site_p.S260_splice|NPR3_ENST00000415685.2_Splice_Site	NM_000908.3|NM_001204375.1	NP_000899.1|NP_001191304.1	P17342	ANPRC_HUMAN	natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C)	476					osteoclast proliferation|positive regulation of urine volume|regulation of blood pressure|regulation of osteoblast proliferation|skeletal system development	integral to membrane	hormone binding|natriuretic peptide receptor activity			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(2)|large_intestine(5)|lung(12)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	24					Nesiritide(DB04899)	TTTTTCAAGCAGGTGGCCTAG	0.458000													10	68					0	0	1	0	0
FOXB2	442425	broad.mit.edu	37	9	79635356	79635356	+	Silent	SNP	C	C	T			TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chr9:79635356C>T	ENST00000376708.1	+	1	786	c.786C>T	c.(784-786)tcC>tcT	p.S262S		NM_001013735.1	NP_001013757.1	Q5VYV0	FOXB2_HUMAN	forkhead box B2	262					brain development|embryo development|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			breast(1)|lung(8)|ovary(1)	10						ccgcGGCGTCCACGTCAGGCT	0.711000													10	47					0	0	1	0	0
DMRTA1	63951	broad.mit.edu	37	9	22447347	22447347	+	Missense_Mutation	SNP	C	C	A			TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chr9:22447347C>A	ENST00000325870.1	+	1	508	c.283C>A	c.(283-285)Ccc>Acc	p.P95T		NM_022160.2	NP_071443.2	Q5VZB9	DMRTA_HUMAN	DMRT-like family A1	95					cell differentiation|sex differentiation	nucleus	DNA binding|metal ion binding|sequence-specific DNA binding transcription factor activity			breast(1)|kidney(1)|large_intestine(3)|lung(6)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	15		all_cancers(5;4.09e-243)|Acute lymphoblastic leukemia(3;8.25e-150)|all_hematologic(3;4.25e-147)|Esophageal squamous(3;2.32e-09)|Renal(3;1.71e-07)|Breast(3;2.07e-06)|Hepatocellular(5;0.00563)		GBM - Glioblastoma multiforme(1;5.12e-278)|Lung(24;8.2e-52)|LUSC - Lung squamous cell carcinoma(38;1.46e-37)|OV - Ovarian serous cystadenocarcinoma(39;0.0517)		CCCGCGGACGCCCAAGTGCGC	0.741000													4	8					0.150653	0.150653	1	1	0
SORCS1	114815	broad.mit.edu	37	10	108377951	108377951	+	Missense_Mutation	SNP	G	G	C			TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chr10:108377951G>C	ENST00000263054.6	-	21	2883	c.2876C>G	c.(2875-2877)gCt>gGt	p.A959G	SORCS1_ENST00000369698.1_Missense_Mutation_p.A494G|SORCS1_ENST00000478809.2_5'UTR|SORCS1_ENST00000344440.6_Missense_Mutation_p.A959G	NM_001206570.1|NM_052918.4	NP_001193499.1|NP_443150.3	Q8WY21	SORC1_HUMAN	sortilin-related VPS10 domain containing receptor 1	959						integral to membrane	neuropeptide receptor activity|protein binding			breast(5)|central_nervous_system(1)|cervix(2)|endometrium(9)|kidney(2)|large_intestine(24)|lung(69)|ovary(1)|prostate(8)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	127		Breast(234;0.0256)|Colorectal(252;0.09)|Lung NSC(174;0.168)		Epithelial(162;1.66e-05)|all cancers(201;0.000689)		GGCATTCCCAGCTGAGACCTG	0.468000													17	60					0	0	1	0	0
TSHZ3	57616	broad.mit.edu	37	19	31767552	31767552	+	Silent	SNP	G	G	T			TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chr19:31767552G>T	ENST00000240587.4	-	2	3474	c.3147C>A	c.(3145-3147)acC>acA	p.T1049T		NM_020856.2	NP_065907.2	Q63HK5	TSH3_HUMAN	teashirt zinc finger homeobox 3	1049					negative regulation of transcription, DNA-dependent|regulation of respiratory gaseous exchange by neurological system process	growth cone|nucleus	chromatin binding|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(4)|endometrium(15)|kidney(9)|large_intestine(20)|lung(60)|ovary(4)|pancreas(2)|prostate(4)|skin(5)	123	Esophageal squamous(110;0.226)					TGCTGGCAAAGGTCCGATTGC	0.493000													14	63					4.3838e-07	5.14301e-07	1	1	0
EPHB6	2051	broad.mit.edu	37	7	142568144	142568144	+	Missense_Mutation	SNP	G	G	C			TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chr7:142568144G>C	ENST00000392957.2	+	18	3572	c.2785G>C	c.(2785-2787)Ggg>Cgg	p.G929R	EPHB6_ENST00000476059.1_3'UTR|EPHB6_ENST00000442129.1_Missense_Mutation_p.G929R|EPHB6_ENST00000411471.2_Missense_Mutation_p.G652R	NM_004445.3	NP_004436.2	O15197	EPHB6_HUMAN	EPH receptor B6	929						extracellular region|integral to plasma membrane	ATP binding|ephrin receptor activity			NS(1)|breast(1)|central_nervous_system(4)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(9)|lung(46)|ovary(2)|pancreas(2)|prostate(1)|skin(9)|stomach(1)|upper_aerodigestive_tract(1)	87	Melanoma(164;0.059)					GCAGGCTGGCGGGGACCCAGG	0.582000													25	115					0	0	1	0	0
FAM135B	51059	broad.mit.edu	37	8	139165439	139165439	+	Missense_Mutation	SNP	G	G	A			TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chr8:139165439G>A	ENST00000395297.1	-	13	1449	c.1279C>T	c.(1279-1281)Cct>Tct	p.P427S		NM_015912.3	NP_056996.2	Q49AJ0	F135B_HUMAN	family with sequence similarity 135, member B	427										NS(3)|breast(9)|endometrium(21)|kidney(5)|large_intestine(28)|liver(1)|lung(135)|ovary(9)|pancreas(1)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(1)	238	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			TCAAAATTAGGATAAACACTC	0.294000										HNSCC(54;0.14)			12	20					0	0	1	0	0
GFAP	2670	broad.mit.edu	37	17	42988741	42988741	+	Silent	SNP	C	C	A			TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chr17:42988741C>A	ENST00000253408.5	-	6	1055	c.990G>T	c.(988-990)cgG>cgT	p.R330R	GFAP_ENST00000435360.2_Silent_p.R330R|GFAP_ENST00000588735.1_Intron|GFAP_ENST00000586793.1_Silent_p.R330R	NM_002055.4	NP_002046.1	P14136	GFAP_HUMAN	glial fibrillary acidic protein	330	Coil 2B.|Rod.					cytoplasm|intermediate filament	structural constituent of cytoskeleton			endometrium(3)|kidney(1)|large_intestine(2)|liver(1)|lung(11)|ovary(1)|pancreas(1)|skin(2)|urinary_tract(1)	23		Prostate(33;0.0959)				CTTCCTCCAGCCGCGCCAGCG	0.657000													20	63					1.56452e-12	2.21993e-12	1	1	0
PNPLA6	10908	broad.mit.edu	37	19	7626097	7626097	+	Missense_Mutation	SNP	A	A	G	rs141102875	by1000genomes	TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chr19:7626097A>G	ENST00000221249.6	+	34	4234	c.3803A>G	c.(3802-3804)gAg>gGg	p.E1268G	PNPLA6_ENST00000600737.1_Missense_Mutation_p.E1306G|PNPLA6_ENST00000545201.2_Missense_Mutation_p.E1241G|PNPLA6_ENST00000450331.3_Missense_Mutation_p.E1268G|PNPLA6_ENST00000414982.3_Missense_Mutation_p.E1316G	NM_006702.4	NP_006693.3	Q8IY17	PLPL6_HUMAN	patatin-like phospholipase domain containing 6	1307					cell death|lipid catabolic process|phosphatidylcholine metabolic process	endoplasmic reticulum membrane|integral to membrane	lysophospholipase activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(6)|lung(14)|ovary(3)|stomach(1)|upper_aerodigestive_tract(1)	35						ATTCCAGGAGAGGAGTCAGAT	0.677000													8	13					0	0	1	0	0
CCDC66	285331	broad.mit.edu	37	3	56653839	56653839	+	Missense_Mutation	SNP	C	C	G			TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chr3:56653839C>G	ENST00000394672.3	+	17	2740	c.2670C>G	c.(2668-2670)gaC>gaG	p.D890E	CCDC66_ENST00000436465.2_Missense_Mutation_p.D890E|CCDC66_ENST00000326595.7_Missense_Mutation_p.D856E	NM_001012506.4|NM_001141947.1	NP_001012524.4|NP_001135419.1	A2RUB6	CCD66_HUMAN	coiled-coil domain containing 66	890										breast(1)|kidney(1)|large_intestine(2)|liver(1)|lung(4)|skin(2)|urinary_tract(1)	12				KIRC - Kidney renal clear cell carcinoma(284;0.0478)|Kidney(284;0.0597)|OV - Ovarian serous cystadenocarcinoma(275;0.233)		TTGATTCTGACTGTGTCAGGG	0.403000													28	127					0	0	1	0	0
COL8A2	1296	broad.mit.edu	37	1	36565756	36565756	+	Missense_Mutation	SNP	C	C	A			TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chr1:36565756C>A	ENST00000397799.1	-	3	312	c.88G>T	c.(88-90)Ggc>Tgc	p.G30C	COL8A2_ENST00000303143.4_Missense_Mutation_p.G30C|COL8A2_ENST00000481785.1_Intron			P25067	CO8A2_HUMAN	collagen, type VIII, alpha 2	30	Nonhelical region (NC2).				angiogenesis|cell-cell adhesion|extracellular matrix organization	basement membrane|collagen	extracellular matrix structural constituent|protein binding, bridging			NS(2)|central_nervous_system(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(1)|lung(4)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	17		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				CCGGCCCCGCCACCAGAGGAC	0.677000											OREG0013361	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	8	27					0.0381472	0.038514	1	1	0
ZNF304	57343	broad.mit.edu	37	19	57868115	57868115	+	Missense_Mutation	SNP	A	A	T			TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chr19:57868115A>T	ENST00000391705.3	+	4	1162	c.878A>T	c.(877-879)cAc>cTc	p.H293L	ZNF304_ENST00000598744.1_Missense_Mutation_p.H251L|ZNF304_ENST00000443917.2_Missense_Mutation_p.H340L|ZNF304_ENST00000282286.5_Missense_Mutation_p.H293L	NM_020657.2	NP_065708.2	Q9HCX3	ZN304_HUMAN	zinc finger protein 304	293					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(15)|ovary(1)	26		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.221)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0265)		CACTTGCACCACCTAAAAATG	0.418000													19	37					0	0	1	0	0
CLCN1	1180	broad.mit.edu	37	7	143048721	143048721	+	Missense_Mutation	SNP	G	G	T			TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chr7:143048721G>T	ENST00000343257.2	+	23	2717	c.2630G>T	c.(2629-2631)gGg>gTg	p.G877V		NM_000083.2	NP_000074.2	P35523	CLCN1_HUMAN	chloride channel, voltage-sensitive 1	877					muscle contraction	chloride channel complex|integral to plasma membrane	voltage-gated chloride channel activity			breast(4)|central_nervous_system(1)|endometrium(1)|large_intestine(11)|lung(26)|ovary(3)|prostate(2)|skin(7)|stomach(1)|upper_aerodigestive_tract(2)	58	Melanoma(164;0.205)					ACCAAGTCTGGGGTGCAGCTC	0.542000													14	33					1.49906e-05	1.68344e-05	1	1	0
SLC19A1	6573	broad.mit.edu	37	21	46945843	46945843	+	Missense_Mutation	SNP	T	T	A			TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chr21:46945843T>A	ENST00000311124.4	-	5	1333	c.1181A>T	c.(1180-1182)gAg>gTg	p.E394V	SLC19A1_ENST00000380010.4_Missense_Mutation_p.E394V|SLC19A1_ENST00000567670.1_Missense_Mutation_p.E394V|SLC19A1_ENST00000485649.2_Missense_Mutation_p.E354V	NM_194255.2	NP_919231.1	P41440	S19A1_HUMAN	solute carrier family 19 (folate transporter), member 1	394					folic acid metabolic process	integral to plasma membrane|membrane fraction	folic acid binding|folic acid transporter activity|methotrexate transporter activity|reduced folate carrier activity			endometrium(4)|kidney(1)|large_intestine(1)|lung(1)|prostate(1)|skin(1)|urinary_tract(1)	10				Colorectal(79;0.0569)|READ - Rectum adenocarcinoma(84;0.172)		GGCACAGAGCTCTTTAGACAG	0.567000													36	103					0	0	1	0	0
MAGT1	84061	broad.mit.edu	37	X	77112343	77112343	+	Missense_Mutation	SNP	C	C	T			TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chrX:77112343C>T	ENST00000358075.6	-	5	741	c.655G>A	c.(655-657)Gct>Act	p.A219T		NM_032121.5	NP_115497.4	Q9H0U3	MAGT1_HUMAN	magnesium transporter 1	187					protein N-linked glycosylation via asparagine	integral to membrane|oligosaccharyltransferase complex				cervix(1)|kidney(2)|large_intestine(3)|lung(9)|prostate(1)|upper_aerodigestive_tract(1)	17						AGGGGACCAGCATAATTTGGG	0.328000													19	44					0	0	1	0	0
EPHA5	2044	broad.mit.edu	37	4	66201803	66201803	+	Missense_Mutation	SNP	G	G	C			TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chr4:66201803G>C	ENST00000273854.3	-	16	3299	c.2699C>G	c.(2698-2700)cCc>cGc	p.P900R	EPHA5_ENST00000432638.2_Missense_Mutation_p.P737R|EPHA5_ENST00000511294.1_Missense_Mutation_p.P901R|EPHA5_ENST00000354839.4_Missense_Mutation_p.P878R	NM_004439.5	NP_004430.4	P54756	EPHA5_HUMAN	EPH receptor A5	900	Protein kinase.				cAMP-mediated signaling|neuron development	dendrite|external side of plasma membrane|integral to plasma membrane|neuronal cell body|perinuclear region of cytoplasm|rough endoplasmic reticulum	ATP binding|transmembrane-ephrin receptor activity			autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(25)|liver(1)|lung(76)|ovary(3)|pancreas(1)|prostate(1)|skin(3)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	142						ACAATCCATGGGGCTTGGCAG	0.443000										TSP Lung(17;0.13)			21	29					0	0	1	0	0
CEP135	9662	broad.mit.edu	37	4	56823520	56823520	+	Missense_Mutation	SNP	G	G	T			TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chr4:56823520G>T	ENST00000257287.4	+	5	728	c.604G>T	c.(604-606)Gct>Tct	p.A202S	CEP135_ENST00000422247.2_Missense_Mutation_p.A202S	NM_025009.4	NP_079285.2	Q66GS9	CP135_HUMAN	centrosomal protein 135kDa	202					centriole replication|centriole-centriole cohesion|G2/M transition of mitotic cell cycle	centriole|cytosol	protein C-terminus binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(9)|lung(26)|ovary(2)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	50	Glioma(25;0.08)|all_neural(26;0.101)					CCTTCAAGTGGCTGATAACAG	0.413000													13	56					7.03913e-09	8.79891e-09	1	1	0
STK11	6794	broad.mit.edu	37	19	1207009	1207009	+	Nonsense_Mutation	SNP	G	G	T			TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chr19:1207009G>T	ENST00000326873.7	+	1	1270	c.97G>T	c.(97-99)Gag>Tag	p.E33*	STK11_ENST00000585748.1_Intron	NM_000455.4	NP_000446.1	Q15831	STK11_HUMAN	serine/threonine kinase 11	33					anoikis|cell cycle arrest|energy reserve metabolic process|insulin receptor signaling pathway|positive regulation of transforming growth factor beta receptor signaling pathway|regulation of fatty acid biosynthetic process|regulation of fatty acid oxidation	cytosol|nucleus	ATP binding|magnesium ion binding|protein serine/threonine kinase activity	p.0?(20)|p.?(3)|p.E33*(1)		biliary_tract(1)|breast(3)|cervix(35)|gastrointestinal_tract_(site_indeterminate)(5)|haematopoietic_and_lymphoid_tissue(7)|kidney(2)|large_intestine(14)|liver(1)|lung(219)|oesophagus(1)|ovary(4)|pancreas(6)|prostate(2)|skin(15)|small_intestine(1)|stomach(9)|testis(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	328		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;7.93e-06)|all_lung(49;1.25e-05)|Breast(49;0.000172)|Renal(1328;0.0183)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|Lung(535;0.00942)|STAD - Stomach adenocarcinoma(1328;0.18)		CGACTCCACCGAGGTCATCTA	0.632000		14	"""D, Mis, N, F, S"""		"""NSCLC, pancreatic"""	"""jejunal harmartoma, ovarian, testicular, pancreatic"""			Peutz-Jeghers syndrome	TSP Lung(3;<1E-08)			10	20					1.76689e-08	2.15725e-08	1	1	0
GRHL3	57822	broad.mit.edu	37	1	24668606	24668606	+	Splice_Site	SNP	T	T	A			TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chr1:24668606T>A	ENST00000361548.4	+	9	1279	c.1047_splice	c.e9-1	p.V350_splice	GRHL3_ENST00000236255.4_Splice_Site_p.V355_splice|GRHL3_ENST00000356046.2_Splice_Site_p.V304_splice|GRHL3_ENST00000350501.5_Splice_Site_p.V350_splice|GRHL3_ENST00000342072.4_Splice_Site_p.V257_splice	NM_198173.2	NP_937816.1	Q8TE85	GRHL3_HUMAN	grainyhead-like 3 (Drosophila)	350					regulation of actin cytoskeleton organization|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)|pancreas(3)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	20		Colorectal(325;3.46e-05)|Renal(390;0.0007)|Lung NSC(340;0.00171)|all_lung(284;0.00226)|Ovarian(437;0.00348)|Breast(348;0.0126)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.19)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;8.72e-25)|Colorectal(126;4.38e-08)|COAD - Colon adenocarcinoma(152;1.84e-06)|GBM - Glioblastoma multiforme(114;0.000132)|BRCA - Breast invasive adenocarcinoma(304;0.00105)|STAD - Stomach adenocarcinoma(196;0.00151)|KIRC - Kidney renal clear cell carcinoma(1967;0.00377)|READ - Rectum adenocarcinoma(331;0.0656)|Lung(427;0.143)		TGTCTCCAGGTGTTCATCGGC	0.572000													49	128					0	0	1	0	0
OBSCN	84033	broad.mit.edu	37	1	228468088	228468088	+	Silent	SNP	G	G	T			TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chr1:228468088G>T	ENST00000570156.2	+	34	9233	c.9159G>T	c.(9157-9159)gcG>gcT	p.A3053A	OBSCN_ENST00000422127.1_Silent_p.A2624A|OBSCN_ENST00000366709.4_5'UTR|OBSCN_ENST00000284548.11_Silent_p.A2624A|OBSCN_ENST00000366707.4_5'UTR|OBSCN_ENST00000359599.6_Silent_p.A1471A	NM_001271223.2	NP_001258152.2	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	2054	Ig-like 30.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			NS(2)|breast(7)|central_nervous_system(5)|cervix(2)|endometrium(30)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(37)|lung(89)|ovary(8)|pancreas(3)|prostate(13)|skin(6)|stomach(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	223		Prostate(94;0.0405)				GGGCTGATGCGGGCATAGTAC	0.622000													4	13					0.00024832	0.000266057	1	1	0
TRIO	7204	broad.mit.edu	37	5	14481384	14481384	+	Silent	SNP	A	A	G			TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chr5:14481384A>G	ENST00000344204.4	+	44	6402	c.6378A>G	c.(6376-6378)tcA>tcG	p.S2126S	TRIO_ENST00000537187.1_Silent_p.S2126S	NM_007118.2	NP_009049.2	O75962	TRIO_HUMAN	trio Rho guanine nucleotide exchange factor	2126	DH 2.				apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|transmembrane receptor protein tyrosine phosphatase signaling pathway	cytosol	ATP binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			NS(2)|breast(6)|central_nervous_system(4)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(21)|lung(34)|ovary(4)|prostate(2)|skin(11)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(4)	118	Lung NSC(4;0.000742)					TGGATACATCAGAATTAGAGG	0.502000													39	199					0	0	1	0	0
PLA2R1	22925	broad.mit.edu	37	2	160898556	160898556	+	Missense_Mutation	SNP	C	C	A			TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chr2:160898556C>A	ENST00000283243.7	-	3	853	c.647G>T	c.(646-648)tGg>tTg	p.W216L	PLA2R1_ENST00000392771.1_Missense_Mutation_p.W216L	NM_001195641.1|NM_007366.4	NP_001182570.1|NP_031392.3	Q13018	PLA2R_HUMAN	phospholipase A2 receptor 1, 180kDa	216	Fibronectin type-II.				endocytosis	extracellular space|integral to plasma membrane	receptor activity|sugar binding		PLA2R1/RBMS1(2)	central_nervous_system(1)|endometrium(8)|kidney(2)|large_intestine(17)|lung(20)|ovary(1)|pancreas(1)|prostate(1)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)	60						GCAAAATCCCCACTTTTCATC	0.393000													23	130					1.66031e-10	2.17915e-10	1	1	0
CFB	629	broad.mit.edu	37	6	31916606	31916606	+	Splice_Site	SNP	G	G	C			TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chr6:31916606G>C	ENST00000456570.1	+	20	2597		c.e20-1		CFB_ENST00000425368.2_Splice_Site|CFB_ENST00000497841.1_Splice_Site|CFB_ENST00000477310.1_Splice_Site|CFB_ENST00000556679.1_Splice_Site			P00751	CFAB_HUMAN	complement factor B						complement activation, alternative pathway|proteolysis	extracellular region|plasma membrane	complement binding|serine-type endopeptidase activity			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(10)|pancreas(1)|skin(1)|urinary_tract(1)	21						CCTCTCCACAGACCACAAGTT	0.512000													18	63					0	0	1	0	0
CYP2C19	1557	broad.mit.edu	37	10	96609703	96609703	+	Silent	SNP	T	T	A			TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chr10:96609703T>A	ENST00000371321.3	+	8	1261	c.1179T>A	c.(1177-1179)tcT>tcA	p.S393S	CYP2C19_ENST00000464755.1_3'UTR	NM_000769.1	NP_000760.1	P33261	CP2CJ_HUMAN	cytochrome P450, family 2, subfamily C, polypeptide 19	393					exogenous drug catabolic process|heterocycle metabolic process|monoterpenoid metabolic process|steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	(S)-limonene 6-monooxygenase activity|(S)-limonene 7-monooxygenase activity|4-hydroxyacetophenone monooxygenase activity|electron carrier activity|enzyme binding|heme binding|oxygen binding|steroid hydroxylase activity			central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(5)|lung(17)|ovary(4)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	43		Colorectal(252;0.09)		all cancers(201;6.02e-07)|KIRC - Kidney renal clear cell carcinoma(50;0.0672)|Kidney(138;0.0838)	Adinazolam(DB00546)|Aminophenazone(DB01424)|Amitriptyline(DB00321)|Amoxicillin(DB01060)|Arformoterol(DB01274)|Bortezomib(DB00188)|Carisoprodol(DB00395)|Chlorzoxazone(DB00356)|Cilostazol(DB01166)|Citalopram(DB00215)|Clarithromycin(DB01211)|Clobazam(DB00349)|Desipramine(DB01151)|Desloratadine(DB00967)|Diclofenac(DB00586)|Diltiazem(DB00343)|Efavirenz(DB00625)|Esomeprazole(DB00736)|Famotidine(DB00927)|Felbamate(DB00949)|Finasteride(DB01216)|Flunitrazepam(DB01544)|Fluvoxamine(DB00176)|Formoterol(DB00983)|Fosphenytoin(DB01320)|Guanfacine(DB01018)|Imipramine(DB00458)|Indomethacin(DB00328)|Ketoconazole(DB01026)|Lansoprazole(DB00448)|Lapatinib(DB01259)|Loratadine(DB00455)|Melatonin(DB01065)|Mephenytoin(DB00532)|Methadone(DB00333)|Methylphenobarbital(DB00849)|Moclobemide(DB01171)|Modafinil(DB00745)|Nelfinavir(DB00220)|Nicardipine(DB00622)|Nilutamide(DB00665)|Norgestrel(DB00506)|Omeprazole(DB00338)|Oxcarbazepine(DB00776)|Pantoprazole(DB00213)|Pentamidine(DB00738)|Phenobarbital(DB01174)|Phenytoin(DB00252)|Primidone(DB00794)|Progesterone(DB00396)|Proguanil(DB01131)|Promazine(DB00420)|Quinidine(DB00908)|Rabeprazole(DB01129)|Ranitidine(DB00863)|Ritonavir(DB00503)|Selegiline(DB01037)|Sertraline(DB01104)|Temazepam(DB00231)|Teniposide(DB00444)|Terfenadine(DB00342)|Thalidomide(DB01041)|Thioridazine(DB00679)|Ticlopidine(DB00208)|Tolbutamide(DB01124)|Topiramate(DB00273)|Tranylcypromine(DB00752)|Troglitazone(DB00197)|Troleandomycin(DB01361)|Voriconazole(DB00582)	CCCTCACTTCTGTGCTACATG	0.398000													19	104					0	0	1	0	0
ADAMTS19	171019	broad.mit.edu	37	5	129039947	129039947	+	Missense_Mutation	SNP	G	G	T			TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chr5:129039947G>T	ENST00000274487.4	+	21	3302	c.3157G>T	c.(3157-3159)Ggc>Tgc	p.G1053C	ADAMTS19_ENST00000509467.1_3'UTR|CTC-575N7.1_ENST00000503616.1_RNA	NM_133638.3	NP_598377.3	Q8TE59	ATS19_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 19	1053	TSP type-1 4.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(4)|endometrium(10)|kidney(9)|large_intestine(14)|lung(34)|ovary(6)|pancreas(1)|prostate(6)|skin(6)	91		all_cancers(142;0.0148)|Prostate(80;0.0494)|Breast(839;0.238)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	OV - Ovarian serous cystadenocarcinoma(64;0.222)		AGTCAAGTGTGGCAAAGGCAT	0.428000													35	100					9.65963e-10	1.24449e-09	1	1	0
ATP13A3	79572	broad.mit.edu	37	3	194165453	194165453	+	Splice_Site	SNP	C	C	A			TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chr3:194165453C>A	ENST00000439040.1	-	15	2351		c.e15+1		ATP13A3_ENST00000256031.4_Splice_Site			Q9H7F0	AT133_HUMAN	ATPase type 13A3						ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			NS(2)|endometrium(3)|kidney(3)|large_intestine(2)|lung(10)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	24	all_cancers(143;6.01e-09)|Ovarian(172;0.0634)	Melanoma(1037;0.211)	OV - Ovarian serous cystadenocarcinoma(49;3.83e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;5.98e-05)		CTAATATTTACCGTGCATTTT	0.313000													25	66					4.7796e-09	6.01028e-09	1	1	0
FAM135B	51059	broad.mit.edu	37	8	139151269	139151269	+	Missense_Mutation	SNP	A	A	C			TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chr8:139151269A>C	ENST00000395297.1	-	18	4031	c.3861T>G	c.(3859-3861)gaT>gaG	p.D1287E		NM_015912.3	NP_056996.2	Q49AJ0	F135B_HUMAN	family with sequence similarity 135, member B	1287										NS(3)|breast(9)|endometrium(21)|kidney(5)|large_intestine(28)|liver(1)|lung(135)|ovary(9)|pancreas(1)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(1)	238	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			ATTTGCGCAAATCAGCATTAT	0.433000										HNSCC(54;0.14)			58	79					0	0	1	0	0
BANK1	55024	broad.mit.edu	37	4	102783751	102783751	+	Silent	SNP	A	A	C			TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chr4:102783751A>C	ENST00000504592.1	+	8	1066	c.648A>C	c.(646-648)acA>acC	p.T216T	BANK1_ENST00000508653.1_Silent_p.T98T|BANK1_ENST00000322953.4_Silent_p.T231T|BANK1_ENST00000428908.1_Silent_p.T98T|BANK1_ENST00000444316.2_Silent_p.T201T			Q8NDB2	BANK1_HUMAN	B-cell scaffold protein with ankyrin repeats 1	231	DBB.				B cell activation					NS(1)|breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|liver(2)|lung(16)|ovary(2)|skin(2)|urinary_tract(1)	44		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;2.7e-07)		TTGAATTTACATCAAGTAATA	0.333000													19	27					0	0	1	0	0
DNAH11	8701	broad.mit.edu	37	7	21847634	21847634	+	Silent	SNP	G	G	T			TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chr7:21847634G>T	ENST00000328843.6	+	64	10351	c.10320G>T	c.(10318-10320)gtG>gtT	p.V3440V	DNAH11_ENST00000409508.3_Silent_p.V3433V			Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	3440					microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(1)|autonomic_ganglia(1)|breast(13)|central_nervous_system(3)|cervix(4)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(50)|lung(101)|ovary(10)|pancreas(4)|prostate(7)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	230						AGGAGCTGGTGCACTGCAAGT	0.468000									Kartagener syndrome				8	9					0.00448238	0.00463695	1	1	0
PAEP	5047	broad.mit.edu	37	9	138454243	138454243	+	Missense_Mutation	SNP	C	C	A			TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chr9:138454243C>A	ENST00000479141.1	+	2	244	c.200C>A	c.(199-201)aCc>aAc	p.T67N	PAEP_ENST00000371766.2_Missense_Mutation_p.T67N|PAEP_ENST00000277508.5_Missense_Mutation_p.T67N	NM_002571.2	NP_002562.2	P09466	PAEP_HUMAN	progestagen-associated endometrial protein	67					multicellular organismal development	extracellular region	binding|transporter activity			cervix(1)|endometrium(1)|lung(1)|prostate(1)|skin(1)|stomach(1)	6				OV - Ovarian serous cystadenocarcinoma(145;3.39e-07)|Epithelial(140;1.11e-06)|all cancers(34;2.04e-05)		CTGTTGCCCACCCCCGAGGAC	0.622000													14	55					1.15088e-07	1.36545e-07	1	1	0
SMOC1	64093	broad.mit.edu	37	14	70490118	70490118	+	Silent	SNP	C	C	A			TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chr14:70490118C>A	ENST00000381280.4	+	11	1498	c.1245C>A	c.(1243-1245)gtC>gtA	p.V415V	SMOC1_ENST00000361956.3_Silent_p.V415V	NM_001034852.2|NM_022137.5	NP_001030024.1|NP_071420.1	Q9H4F8	SMOC1_HUMAN	SPARC related modular calcium binding 1	415	EF-hand 2.				cell differentiation|eye development|limb development|regulation of osteoblast differentiation|signal transduction	basement membrane	calcium ion binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(10)|ovary(1)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	21				all cancers(60;0.00417)|BRCA - Breast invasive adenocarcinoma(234;0.0119)|OV - Ovarian serous cystadenocarcinoma(108;0.028)		AAGACAAGGTCATTTCACTGC	0.547000													51	199					3.85841e-42	6.64153e-42	1	1	0
DNAJC12	56521	broad.mit.edu	37	10	69565452	69565452	+	Nonsense_Mutation	SNP	C	C	A			TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chr10:69565452C>A	ENST00000225171.2	-	4	543	c.391G>T	c.(391-393)Gag>Tag	p.E131*	DNAJC12_ENST00000483798.2_Nonsense_Mutation_p.E161*	NM_021800.2	NP_068572.1	Q9UKB3	DJC12_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 12	131					protein folding		heat shock protein binding|unfolded protein binding			breast(2)|kidney(2)|large_intestine(1)|lung(6)|upper_aerodigestive_tract(1)	12						TCTCTTTGCTCATTACATTCC	0.443000													46	97					4.44401e-20	6.91291e-20	1	1	0
UHRF2	115426	broad.mit.edu	37	9	6499927	6499927	+	Silent	SNP	A	A	G			TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chr9:6499927A>G	ENST00000276893.5	+	13	2169	c.2001A>G	c.(1999-2001)tcA>tcG	p.S667S	UHRF2_ENST00000485617.2_3'UTR	NM_152896.2	NP_690856.1	Q96PU4	UHRF2_HUMAN	ubiquitin-like with PHD and ring finger domains 2, E3 ubiquitin protein ligase	667					cell cycle|cell differentiation|cell proliferation|protein autoubiquitination|regulation of cell cycle|ubiquitin-dependent protein catabolic process	nucleus	DNA binding|histone binding|ubiquitin-protein ligase activity|zinc ion binding			cervix(2)|endometrium(2)|kidney(3)|large_intestine(4)|lung(5)|ovary(1)	17		Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.0392)|Lung(218;0.129)		GGCCAATTTCAGATGGTAGGT	0.428000													3	28					0	0	1	0	0
IGSF10	285313	broad.mit.edu	37	3	151155474	151155474	+	Missense_Mutation	SNP	A	A	T			TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chr3:151155474A>T	ENST00000282466.3	-	6	6874	c.6875T>A	c.(6874-6876)gTc>gAc	p.V2292D	IGSF10_ENST00000495443.1_5'UTR	NM_001178145.1|NM_001178146.1|NM_178822.4	NP_001171616.1|NP_001171617.1|NP_849144.2	Q6WRI0	IGS10_HUMAN	immunoglobulin superfamily, member 10	2292	Ig-like C2-type 9.				cell differentiation|multicellular organismal development|ossification	extracellular region				NS(1)|breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(24)|liver(4)|lung(43)|ovary(8)|prostate(4)|skin(9)|stomach(1)|urinary_tract(3)	116			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			ATTTTTATGGACTGTGATTCT	0.458000													18	67					0	0	1	0	0
KCNU1	157855	broad.mit.edu	37	8	36776396	36776396	+	Silent	SNP	C	C	T			TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chr8:36776396C>T	ENST00000399881.3	+	23	2614	c.2577C>T	c.(2575-2577)gtC>gtT	p.V859V		NM_001031836.2	NP_001027006.2	A8MYU2	KCNU1_HUMAN	potassium channel, subfamily U, member 1	859						voltage-gated potassium channel complex	binding|large conductance calcium-activated potassium channel activity|voltage-gated potassium channel activity			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(8)|kidney(1)|large_intestine(9)|lung(31)|ovary(1)|urinary_tract(1)	57				KIRC - Kidney renal clear cell carcinoma(67;0.0504)|Kidney(114;0.0634)		GCCGAAAAGTCCCTATCCTTA	0.363000													40	48					0	0	1	0	0
OR2M4	26245	broad.mit.edu	37	1	248403038	248403038	+	Missense_Mutation	SNP	C	C	A			TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chr1:248403038C>A	ENST00000306687.1	+	1	808	c.808C>A	c.(808-810)Cag>Aag	p.Q270K		NM_017504.1	NP_059974.1	Q96R27	OR2M4_HUMAN	olfactory receptor, family 2, subfamily M, member 4	270					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(8)|lung(27)|skin(3)|upper_aerodigestive_tract(2)	50	all_cancers(71;0.000124)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			TACGCCAGACCAGGACAAGAT	0.507000													12	111					6.31663e-08	7.57995e-08	1	1	0
PLRG1	5356	broad.mit.edu	37	4	155459138	155459138	+	Missense_Mutation	SNP	C	C	A			TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chr4:155459138C>A	ENST00000499023.2	-	13	1400	c.1274G>T	c.(1273-1275)gGa>gTa	p.G425V	PLRG1_ENST00000393905.2_Missense_Mutation_p.G425V|PLRG1_ENST00000302078.5_Missense_Mutation_p.G416V	NM_001201564.1|NM_002669.3	NP_001188493.1|NP_002660.1	O43660	PLRG1_HUMAN	pleiotropic regulator 1	425						catalytic step 2 spliceosome|nuclear speck	protein binding|signal transducer activity|transcription corepressor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(11)|skin(1)|urinary_tract(1)	22	all_hematologic(180;0.215)	Renal(120;0.0854)				TACAAGCACTCCATCAGAATT	0.294000													5	57					0.000602214	0.000638712	1	1	0
CSMD2	114784	broad.mit.edu	37	1	34118028	34118028	+	Missense_Mutation	SNP	C	C	A			TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chr1:34118028C>A	ENST00000373381.4	-	28	4657	c.4481G>T	c.(4480-4482)gGa>gTa	p.G1494V	CSMD2_ENST00000373380.1_Missense_Mutation_p.G367V|CSMD2_ENST00000373388.2_5'UTR	NM_052896.3	NP_443128.2	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	1454	CUB 9.					integral to membrane|plasma membrane	protein binding			NS(5)|breast(5)|central_nervous_system(3)|cervix(2)|endometrium(20)|haematopoietic_and_lymphoid_tissue(4)|kidney(9)|large_intestine(43)|lung(114)|ovary(8)|pancreas(1)|prostate(6)|skin(20)|upper_aerodigestive_tract(5)|urinary_tract(1)	246		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				GAGGATGACTCCAGATGGTCC	0.562000													20	98					4.96729e-08	5.99501e-08	1	1	0
MUC16	94025	broad.mit.edu	37	19	9048251	9048251	+	Missense_Mutation	SNP	G	G	A			TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chr19:9048251G>A	ENST00000397910.4	-	5	33583	c.33380C>T	c.(33379-33381)cCt>cTt	p.P11127L		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	11129	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GGCCATTGAAGGTGTGGTCTC	0.498000													33	50					0	0	1	0	0
KCNT2	343450	broad.mit.edu	37	1	196205148	196205148	+	Silent	SNP	A	A	T			TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chr1:196205148A>T	ENST00000367433.5	-	26	3293	c.3192T>A	c.(3190-3192)tcT>tcA	p.S1064S	KCNT2_ENST00000367431.4_Silent_p.S1022S|KCNT2_ENST00000451324.2_3'UTR|KCNT2_ENST00000498426.1_5'UTR|KCNT2_ENST00000294725.8_Silent_p.S1088S			Q6UVM3	KCNT2_HUMAN	potassium channel, subfamily T, member 2	1088						voltage-gated potassium channel complex	ATP binding|calcium-activated potassium channel activity|voltage-gated potassium channel activity			NS(1)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(16)|lung(43)|ovary(5)|pancreas(1)|prostate(1)|skin(11)|stomach(2)|upper_aerodigestive_tract(1)	97						TGGTATCTGGAGATGGGTTAA	0.299000													71	191					0	0	1	0	0
PTH1R	5745	broad.mit.edu	37	3	46944040	46944040	+	Silent	SNP	G	G	T			TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chr3:46944040G>T	ENST00000449590.1	+	14	1439	c.1236G>T	c.(1234-1236)gtG>gtT	p.V412V	PTH1R_ENST00000430002.2_Silent_p.V412V|PTH1R_ENST00000418619.1_Silent_p.V412V|PTH1R_ENST00000313049.5_Silent_p.V412V	NM_000316.2	NP_000307.1	Q03431	PTH1R_HUMAN	parathyroid hormone 1 receptor	412						cytoplasm|integral to plasma membrane|nucleus	parathyroid hormone receptor activity|peptide hormone binding|protein self-association			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(3)|liver(1)|lung(5)|skin(2)|stomach(1)|urinary_tract(2)	19						CCACGCTGGTGCTCATGCCCC	0.597000													5	16					0.0215528	0.0218651	1	1	0
LRRC17	10234	broad.mit.edu	37	7	102580021	102580021	+	Missense_Mutation	SNP	T	T	G			TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chr7:102580021T>G	ENST00000249377.4	+	3	1198	c.917T>G	c.(916-918)tTc>tGc	p.F306C	LRRC17_ENST00000339431.4_Missense_Mutation_p.F306C|FBXL13_ENST00000379308.3_Intron|FBXL13_ENST00000379305.3_Intron|FBXL13_ENST00000436908.1_Intron|FBXL13_ENST00000456695.1_Intron|FBXL13_ENST00000313221.4_Intron|FBXL13_ENST00000455112.2_Intron|FBXL13_ENST00000379306.3_Intron|LRRC17_ENST00000485478.1_3'UTR|FBXL13_ENST00000393772.2_Intron	NM_005824.2	NP_005815.2	Q8N6Y2	LRC17_HUMAN	leucine rich repeat containing 17	306					bone marrow development|negative regulation of osteoclast differentiation|ossification	extracellular space				NS(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(5)|liver(2)|lung(3)|ovary(1)|prostate(1)|urinary_tract(1)	17						GGCATTGAATTCATCGATCCT	0.383000													18	97					0	0	1	0	0
TAF5L	27097	broad.mit.edu	37	1	229730303	229730303	+	Missense_Mutation	SNP	T	T	G			TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chr1:229730303T>G	ENST00000258281.2	-	5	1676	c.1511A>C	c.(1510-1512)aAa>aCa	p.K504T	TAF5L_ENST00000366676.1_Missense_Mutation_p.K504T	NM_014409.3	NP_055224.1	O75529	TAF5L_HUMAN	TAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa	504					histone H3 acetylation|transcription from RNA polymerase II promoter	STAGA complex|transcription factor TFTC complex	sequence-specific DNA binding transcription factor activity|transcription coactivator activity			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(2)|lung(4)|ovary(1)	11	Breast(184;0.193)|Ovarian(103;0.249)	Prostate(94;0.167)				TCTCAACTCTTTATAAAGGGT	0.562000													8	94					0	0	1	0	0
PDCD1LG2	80380	broad.mit.edu	37	9	5549474	5549474	+	Silent	SNP	C	C	A	rs56043856		TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chr9:5549474C>A	ENST00000397747.3	+	4	749	c.501C>A	c.(499-501)tcC>tcA	p.S167S	PDCD1LG2_ENST00000397745.2_Intron	NM_025239.3	NP_079515.2	Q9BQ51	PD1L2_HUMAN	programmed cell death 1 ligand 2	167	Ig-like C2-type.				immune response|T cell costimulation	endomembrane system|extracellular region|integral to membrane|plasma membrane	receptor activity			large_intestine(2)|lung(4)|prostate(2)	8	all_hematologic(13;0.158)	Acute lymphoblastic leukemia(23;0.154)		GBM - Glioblastoma multiforme(50;0.000767)|Lung(218;0.112)		CCAGCCACTCCAGGACCCCTG	0.562000													16	51					3.45872e-05	3.84302e-05	1	1	0
PIM2	11040	broad.mit.edu	37	X	48776079	48776079	+	Silent	SNP	C	C	A			TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chrX:48776079C>A	ENST00000376509.4	-	1	222	c.33G>T	c.(31-33)gcG>gcT	p.A11A		NM_006875.3	NP_006866.2	Q9P1W9	PIM2_HUMAN	pim-2 oncogene	11					anti-apoptosis|cell proliferation|male meiosis|positive regulation of autophagy|positive regulation of I-kappaB kinase/NF-kappaB cascade|response to virus		ATP binding|protein serine/threonine kinase activity			lung(3)|stomach(1)	4						TCCCGGGGGGCGCGGGAGGCC	0.701000													12	15					6.72482e-11	8.88184e-11	1	1	0
DMRTA1	63951	broad.mit.edu	37	9	22447346	22447346	+	Silent	SNP	G	G	A			TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chr9:22447346G>A	ENST00000325870.1	+	1	507	c.282G>A	c.(280-282)acG>acA	p.T94T		NM_022160.2	NP_071443.2	Q5VZB9	DMRTA_HUMAN	DMRT-like family A1	94					cell differentiation|sex differentiation	nucleus	DNA binding|metal ion binding|sequence-specific DNA binding transcription factor activity			breast(1)|kidney(1)|large_intestine(3)|lung(6)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	15		all_cancers(5;4.09e-243)|Acute lymphoblastic leukemia(3;8.25e-150)|all_hematologic(3;4.25e-147)|Esophageal squamous(3;2.32e-09)|Renal(3;1.71e-07)|Breast(3;2.07e-06)|Hepatocellular(5;0.00563)		GBM - Glioblastoma multiforme(1;5.12e-278)|Lung(24;8.2e-52)|LUSC - Lung squamous cell carcinoma(38;1.46e-37)|OV - Ovarian serous cystadenocarcinoma(39;0.0517)		ACCCGCGGACGCCCAAGTGCG	0.746000													4	8					0	0	1	0	0
OR5H14	403273	broad.mit.edu	37	3	97868314	97868314	+	Missense_Mutation	SNP	C	C	A			TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chr3:97868314C>A	ENST00000437310.1	+	1	145	c.85C>A	c.(85-87)Ctg>Atg	p.L29M		NM_001005514.1	NP_001005514.1	A6NHG9	O5H14_HUMAN	olfactory receptor, family 5, subfamily H, member 14	29					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.L29M(1)		breast(1)|central_nervous_system(2)|endometrium(3)|kidney(1)|large_intestine(3)|lung(17)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	31						ACCCCTGTTCCTGGCATTCTT	0.418000													78	136					9.53938e-30	1.57738e-29	1	1	0
DENND1A	57706	broad.mit.edu	37	9	126144811	126144811	+	Missense_Mutation	SNP	C	C	A			TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chr9:126144811C>A	ENST00000373624.2	-	22	2131	c.1930G>T	c.(1930-1932)Gac>Tac	p.D644Y	DENND1A_ENST00000473039.1_5'UTR|DENND1A_ENST00000542603.1_Missense_Mutation_p.D429Y|DENND1A_ENST00000394219.3_Missense_Mutation_p.D655Y	NM_020946.1	NP_065997.1	Q8TEH3	DEN1A_HUMAN	DENN/MADD domain containing 1A	644						cell junction|clathrin coated vesicle membrane|presynaptic membrane	guanyl-nucleotide exchange factor activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|liver(2)|lung(18)|ovary(2)|prostate(1)|skin(1)|stomach(1)	43						GCCATGTCGTCCTGGCCCAGG	0.662000													35	82					2.05212e-20	3.21601e-20	1	1	0
NOX3	50508	broad.mit.edu	37	6	155761216	155761216	+	Missense_Mutation	SNP	G	G	A			TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chr6:155761216G>A	ENST00000159060.2	-	6	644	c.542C>T	c.(541-543)tCt>tTt	p.S181F		NM_015718.2	NP_056533.1	Q9HBY0	NOX3_HUMAN	NADPH oxidase 3	181	Ferric oxidoreductase.						electron carrier activity|flavin adenine dinucleotide binding|iron ion binding			cervix(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(16)|ovary(1)|pancreas(1)|prostate(4)|upper_aerodigestive_tract(1)	45		Breast(66;0.0183)		OV - Ovarian serous cystadenocarcinoma(155;2.18e-12)|BRCA - Breast invasive adenocarcinoma(81;0.00815)		TAAAGCCAGAGAGATCACCAG	0.398000													11	52					0	0	1	0	0
PXDNL	137902	broad.mit.edu	37	8	52284553	52284553	+	Missense_Mutation	SNP	C	C	T			TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chr8:52284553C>T	ENST00000356297.4	-	19	3881	c.3781G>A	c.(3781-3783)Ggt>Agt	p.G1261S	PXDNL_ENST00000543296.1_Missense_Mutation_p.G1261S	NM_144651.4	NP_653252.3	A1KZ92	PXDNL_HUMAN	peroxidasin homolog (Drosophila)-like	1261					hydrogen peroxide catabolic process	extracellular space	heme binding|peroxidase activity			NS(1)|breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(6)|lung(25)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	48		all_cancers(86;0.107)|Lung NSC(129;0.00641)|all_epithelial(80;0.00716)|all_lung(136;0.015)				ATGCTGTCACCATTGTCACAA	0.527000													24	20					0	0	1	0	0
GPATCH2	55105	broad.mit.edu	37	1	217604609	217604609	+	Missense_Mutation	SNP	C	C	T			TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chr1:217604609C>T	ENST00000366935.3	-	10	1575	c.1465G>A	c.(1465-1467)Gat>Aat	p.D489N		NM_018040.2	NP_060510.1	Q9NW75	GPTC2_HUMAN	G patch domain containing 2	489	G-patch.					intracellular	nucleic acid binding			NS(1)|breast(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(17)|ovary(1)|prostate(1)|skin(3)|stomach(1)	35				OV - Ovarian serous cystadenocarcinoma(81;0.0397)|all cancers(67;0.0744)|GBM - Glioblastoma multiforme(131;0.0872)		CCCTTGCCATCTCGTCCAAGG	0.483000													12	219					0	0	1	0	0
SLC16A7	9194	broad.mit.edu	37	12	60098626	60098626	+	Translation_Start_Site	SNP	A	A	T			TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chr12:60098626A>T	ENST00000543448.1	+	0	192				SLC16A7_ENST00000549588.1_3'UTR|SLC16A7_ENST00000547379.1_Missense_Mutation_p.D15V|SLC16A7_ENST00000552024.1_Missense_Mutation_p.D15V|SLC16A7_ENST00000261187.4_Missense_Mutation_p.D15V|SLC16A7_ENST00000549465.1_Missense_Mutation_p.D15V|SLC16A7_ENST00000552432.1_Missense_Mutation_p.D15V			O60669	MOT2_HUMAN	solute carrier family 16 (monocarboxylate transporter), member 7							integral to plasma membrane|membrane fraction	pyruvate secondary active transmembrane transporter activity|secondary active monocarboxylate transmembrane transporter activity|symporter activity			endometrium(1)|large_intestine(14)|liver(2)|lung(11)|ovary(1)|skin(1)	30				GBM - Glioblastoma multiforme(3;0.0303)	Pyruvic acid(DB00119)	CCACCTCCAGATGGAGGATGG	0.428000													24	17					0	0	1	0	0
SLITRK3	22865	broad.mit.edu	37	3	164905921	164905921	+	Missense_Mutation	SNP	C	C	A			TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chr3:164905921C>A	ENST00000475390.1	-	2	3141	c.2698G>T	c.(2698-2700)Gtg>Ttg	p.V900L	SLITRK3_ENST00000241274.3_Missense_Mutation_p.V900L			O94933	SLIK3_HUMAN	SLIT and NTRK-like family, member 3	900						integral to membrane				NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(14)|lung(66)|ovary(6)|pancreas(1)|prostate(4)|skin(5)|upper_aerodigestive_tract(5)	119						AGACAGTCCACAAATCCCACT	0.557000										HNSCC(40;0.11)			32	49					2.61193e-14	3.86272e-14	1	1	0
USH2A	7399	broad.mit.edu	37	1	216420259	216420259	+	Missense_Mutation	SNP	C	C	A			TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chr1:216420259C>A	ENST00000366943.2	-	13	2863	c.2477G>T	c.(2476-2478)tGc>tTc	p.C826F	USH2A_ENST00000366942.3_Missense_Mutation_p.C826F|USH2A_ENST00000307340.3_Missense_Mutation_p.C826F			O75445	USH2A_HUMAN	Usher syndrome 2A (autosomal recessive, mild)	826	Laminin EGF-like 6.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			NS(7)|breast(20)|central_nervous_system(3)|cervix(2)|endometrium(32)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(71)|liver(2)|lung(282)|ovary(25)|pancreas(2)|prostate(12)|skin(22)|stomach(7)|upper_aerodigestive_tract(20)|urinary_tract(3)	527				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		ACATTTATTGCACTGTCTCCC	0.478000										HNSCC(13;0.011)			22	140					2.89027e-11	3.8415e-11	1	1	0
DLGAP3	58512	broad.mit.edu	37	1	35370048	35370048	+	Missense_Mutation	SNP	G	G	T			TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chr1:35370048G>T	ENST00000373347.1	-	3	1205	c.937C>A	c.(937-939)Ctt>Att	p.L313I	DLGAP3_ENST00000235180.4_Missense_Mutation_p.L313I			O95886	DLGP3_HUMAN	discs, large (Drosophila) homolog-associated protein 3	313					cell-cell signaling	cell junction|postsynaptic density|postsynaptic membrane				central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(23)|ovary(4)|prostate(3)|skin(3)|urinary_tract(1)	46		Myeloproliferative disorder(586;0.0393)				GTGCAGGCAAGGCAGCGGCCT	0.652000													28	63					1.12875e-08	1.39434e-08	1	1	0
USP32	84669	broad.mit.edu	37	17	58297057	58297057	+	Missense_Mutation	SNP	T	T	A			TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chr17:58297057T>A	ENST00000300896.4	-	16	2035	c.1841A>T	c.(1840-1842)cAg>cTg	p.Q614L	USP32_ENST00000592339.1_Missense_Mutation_p.Q284L	NM_032582.3	NP_115971.2	Q8NFA0	UBP32_HUMAN	ubiquitin specific peptidase 32	614					protein deubiquitination|ubiquitin-dependent protein catabolic process	Golgi apparatus|membrane	calcium ion binding|cysteine-type peptidase activity|ubiquitin thiolesterase activity			NS(3)|breast(5)|endometrium(5)|kidney(4)|large_intestine(12)|liver(1)|lung(24)|pancreas(1)|prostate(3)|skin(3)|urinary_tract(1)	62	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		Epithelial(12;2.02e-11)|all cancers(12;5.23e-10)|Colorectal(3;0.198)			GTTAGACTGCTGTGTCCGAGT	0.453000													13	65					0	0	1	0	0
EFCAB2	84288	broad.mit.edu	37	1	245250578	245250578	+	Silent	SNP	A	A	G			TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chr1:245250578A>G	ENST00000366523.1	+	8	670	c.405A>G	c.(403-405)gaA>gaG	p.E135E	EFCAB2_ENST00000487845.1_Intron|EFCAB2_ENST00000447569.2_Intron|EFCAB2_ENST00000366522.2_Intron	NM_032328.3	NP_115704.1	Q5VUJ9	EFCB2_HUMAN	EF-hand calcium binding domain 2	0							calcium ion binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(4)|prostate(1)|stomach(2)	13	all_cancers(71;2.93e-06)|all_epithelial(71;2.13e-05)|all_lung(81;0.0337)|Lung NSC(105;0.0472)|Ovarian(71;0.0584)|Breast(184;0.0716)|all_neural(11;0.0982)		OV - Ovarian serous cystadenocarcinoma(106;0.015)			AAATGGAAGAAATGTTGTCTG	0.318000													4	58					0	0	1	0	0
C11orf42	160298	broad.mit.edu	37	11	6231843	6231843	+	Missense_Mutation	SNP	G	G	A			TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chr11:6231843G>A	ENST00000316375.2	+	2	886	c.836G>A	c.(835-837)cGa>cAa	p.R279Q		NM_173525.2	NP_775796.2	Q8N5U0	CK042_HUMAN	chromosome 11 open reading frame 42	279	Pro-rich.									endometrium(3)|kidney(3)|large_intestine(1)|lung(4)|ovary(2)|skin(1)|soft_tissue(1)	15		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;1.95e-08)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TACAAGGGCCGAAACCCCTTC	0.582000													35	35					0	0	1	0	0
OR2L3	391192	broad.mit.edu	37	1	248224700	248224700	+	Silent	SNP	C	C	A			TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chr1:248224700C>A	ENST00000359959.3	+	1	717	c.717C>A	c.(715-717)acC>acA	p.T239T	OR2L13_ENST00000366478.2_Intron	NM_001004687.1	NP_001004687.1	Q8NG85	OR2L3_HUMAN	olfactory receptor, family 2, subfamily L, member 3	239					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|endometrium(2)|large_intestine(7)|lung(28)|prostate(1)|skin(1)|urinary_tract(1)	41	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0278)			CCTACCTGACCTGCAGCACCC	0.478000													24	214					3.28513e-13	4.69304e-13	1	1	0
DENND2C	163259	broad.mit.edu	37	1	115166139	115166139	+	Missense_Mutation	SNP	T	T	C			TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chr1:115166139T>C	ENST00000393274.1	-	5	1557	c.932A>G	c.(931-933)gAa>gGa	p.E311G	DENND2C_ENST00000481894.1_Intron|DENND2C_ENST00000393277.1_Missense_Mutation_p.E311G|DENND2C_ENST00000393276.3_Missense_Mutation_p.E311G	NM_001256404.1	NP_001243333.1	Q68D51	DEN2C_HUMAN	DENN/MADD domain containing 2C	311										NS(2)|breast(2)|cervix(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|lung(10)|pancreas(1)|skin(3)	37	all_epithelial(7;9.54e-05)|all_lung(7;0.000179)|Lung NSC(6;0.00195)|Lung SC(450;0.211)	all_cancers(81;4.64e-07)|all_epithelial(167;4.2e-07)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		TATGATATCTTCATAGATATT	0.353000													3	31					0	0	1	0	0
PRUNE2	158471	broad.mit.edu	37	9	79326177	79326177	+	Missense_Mutation	SNP	G	G	T			TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chr9:79326177G>T	ENST00000376718.3	-	8	1136	c.1013C>A	c.(1012-1014)cCt>cAt	p.P338H	PRUNE2_ENST00000428286.1_5'UTR	NM_015225.2	NP_056040.2	Q8WUY3	PRUN2_HUMAN	prune homolog 2 (Drosophila)	338					apoptosis|G1 phase|induction of apoptosis	cytoplasm	metal ion binding|pyrophosphatase activity			endometrium(1)|kidney(4)|large_intestine(3)|lung(7)|prostate(1)	16						AGTCACTGAAGGGTCCTCTTG	0.512000													6	13					0.00116845	0.00123303	1	1	0
SH3TC2	79628	broad.mit.edu	37	5	148406461	148406461	+	Missense_Mutation	SNP	A	A	T			TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chr5:148406461A>T	ENST00000538184.1	-	7	2363	c.1475T>A	c.(1474-1476)aTg>aAg	p.M492K	SH3TC2_ENST00000394358.2_Missense_Mutation_p.M830K|SH3TC2_ENST00000512049.1_Missense_Mutation_p.M938K|SH3TC2_ENST00000515425.1_Missense_Mutation_p.M945K			Q8TF17	S3TC2_HUMAN	SH3 domain and tetratricopeptide repeats 2	945							binding			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(12)|ovary(3)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	39			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CAGCAATGCCATTTCATAACA	0.443000													30	140					0	0	1	0	0
HCN1	348980	broad.mit.edu	37	5	45695938	45695938	+	Silent	SNP	C	C	A			TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chr5:45695938C>A	ENST00000303230.4	-	1	315	c.258G>T	c.(256-258)ggG>ggT	p.G86G		NM_021072.3	NP_066550.2	O60741	HCN1_HUMAN	hyperpolarization activated cyclic nucleotide-gated potassium channel 1	86						integral to membrane	cAMP binding|sodium channel activity|voltage-gated potassium channel activity			NS(3)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(21)|liver(1)|lung(98)|ovary(1)|prostate(7)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(5)	156						GCCGCCGGGGCCCCTCGGCGT	0.706000													11	23					9.05144e-12	1.25053e-11	1	1	0
LRTOMT	220074	broad.mit.edu	37	11	71804553	71804553	+	Missense_Mutation	SNP	G	G	A			TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chr11:71804553G>A	ENST00000324866.7	+	4	260	c.94G>A	c.(94-96)Gag>Aag	p.E32K	LAMTOR1_ENST00000545249.1_Intron|LRTOMT_ENST00000536917.1_Missense_Mutation_p.E32K|LRTOMT_ENST00000419228.1_5'UTR|LRTOMT_ENST00000538478.1_Missense_Mutation_p.E32K|LRTOMT_ENST00000289488.2_Missense_Mutation_p.E32K|LRTOMT_ENST00000439209.1_Missense_Mutation_p.E32K|LRTOMT_ENST00000541614.1_Missense_Mutation_p.E32K|LRTOMT_ENST00000423494.2_Missense_Mutation_p.E14K|LRTOMT_ENST00000539271.1_5'UTR|LRTOMT_ENST00000447974.1_Missense_Mutation_p.E32K|LRTOMT_ENST00000435085.1_5'UTR|LRTOMT_ENST00000539587.1_Intron|LRTOMT_ENST00000307198.7_5'UTR	NM_001271471.2	NP_001258400.1	Q96E66	LRC51_HUMAN	leucine rich transmembrane and O-methyltransferase domain containing	32						cytoplasm				large_intestine(2)|lung(1)|ovary(1)	4						TCTGGTAAATGAGGAGCCAAG	0.488000													4	19					0	0	1	0	0
SORCS2	57537	broad.mit.edu	37	4	7691293	7691293	+	Silent	SNP	C	C	T			TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chr4:7691293C>T	ENST00000507866.2	+	11	1678	c.1569C>T	c.(1567-1569)gcC>gcT	p.A523A	SORCS2_ENST00000329016.9_Silent_p.A351A	NM_020777.2	NP_065828.2	Q96PQ0	SORC2_HUMAN	sortilin-related VPS10 domain containing receptor 2	523						integral to membrane	neuropeptide receptor activity			autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(4)|large_intestine(8)|lung(8)|ovary(2)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	42						AGGACACCGCCCCAGGCCTCA	0.587000													4	10					0	0	1	0	0
PABPC4	8761	broad.mit.edu	37	1	40041491	40041491	+	Missense_Mutation	SNP	C	C	A			TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chr1:40041491C>A	ENST00000372857.3	-	1	925	c.133G>T	c.(133-135)Gat>Tat	p.D45Y	PABPC4_ENST00000372862.3_Missense_Mutation_p.D45Y|PABPC4_ENST00000372856.3_Missense_Mutation_p.D45Y|PABPC4_ENST00000372858.3_Missense_Mutation_p.D45Y	NM_003819.3	NP_003810.1	Q13310	PABP4_HUMAN	poly(A) binding protein, cytoplasmic 4 (inducible form)	45	RRM 1.				blood coagulation|RNA catabolic process|RNA processing|translation	cytoplasm|ribonucleoprotein complex	nucleotide binding|poly(A) RNA binding|poly(U) RNA binding|protein binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(5)|liver(1)|lung(6)|prostate(1)|skin(3)	21	Lung NSC(20;1.55e-06)|Ovarian(52;0.00769)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;2.89e-18)|Epithelial(16;6.17e-17)|all cancers(16;1.18e-15)|LUSC - Lung squamous cell carcinoma(16;0.000261)|Lung(16;0.000457)			GTGATCATATCGCGGCAGACC	0.652000													15	31					0.000566183	0.000603546	1	1	0
FAM135B	51059	broad.mit.edu	37	8	139164901	139164901	+	Missense_Mutation	SNP	G	G	A			TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chr8:139164901G>A	ENST00000395297.1	-	13	1987	c.1817C>T	c.(1816-1818)tCt>tTt	p.S606F		NM_015912.3	NP_056996.2	Q49AJ0	F135B_HUMAN	family with sequence similarity 135, member B	606										NS(3)|breast(9)|endometrium(21)|kidney(5)|large_intestine(28)|liver(1)|lung(135)|ovary(9)|pancreas(1)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(1)	238	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			TTTGTCTGAAGAGATGGCATT	0.453000										HNSCC(54;0.14)			119	139					0	0	1	0	0
UBR1	197131	broad.mit.edu	37	15	43360190	43360190	+	Missense_Mutation	SNP	T	T	A			TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chr15:43360190T>A	ENST00000290650.4	-	6	782	c.704A>T	c.(703-705)cAc>cTc	p.H235L	UBR1_ENST00000382177.2_Missense_Mutation_p.H235L	NM_174916.2	NP_777576.1	Q8IWV7	UBR1_HUMAN	ubiquitin protein ligase E3 component n-recognin 1	235					cellular response to leucine|negative regulation of TOR signaling cascade	cytosol	leucine binding|zinc ion binding			NS(2)|endometrium(2)|kidney(7)|large_intestine(12)|lung(25)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	58		all_cancers(109;4.32e-15)|all_epithelial(112;4.05e-13)|Lung NSC(122;1.75e-08)|all_lung(180;2e-07)|Melanoma(134;0.0179)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;4.08e-07)|COAD - Colon adenocarcinoma(120;0.185)|Colorectal(105;0.214)		ATATGAATGGTGTTCATCATT	0.368000													27	47					0	0	1	0	0
HECW1	23072	broad.mit.edu	37	7	43540318	43540318	+	Missense_Mutation	SNP	G	G	A			TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chr7:43540318G>A	ENST00000395891.1	+	20	4063	c.3458G>A	c.(3457-3459)cGg>cAg	p.R1153Q	HECW1_ENST00000453890.1_Missense_Mutation_p.R1119Q	NM_015052.3	NP_055867.3	Q76N89	HECW1_HUMAN	HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1	1153					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	ubiquitin-protein ligase activity			NS(2)|breast(10)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(17)|lung(57)|ovary(8)|pancreas(2)|prostate(2)|skin(6)|urinary_tract(3)	125						CATTACATTCGGACTGAGGGT	0.418000													23	149					0	0	1	0	0
SNTG1	54212	broad.mit.edu	37	8	51449356	51449356	+	Missense_Mutation	SNP	C	C	A			TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chr8:51449356C>A	ENST00000522124.1	+	11	1329	c.668C>A	c.(667-669)aCa>aAa	p.T223K	SNTG1_ENST00000517473.1_Missense_Mutation_p.T223K|SNTG1_ENST00000276467.5_Missense_Mutation_p.T223K|SNTG1_ENST00000518864.1_Missense_Mutation_p.T223K	NM_018967.2	NP_061840.1	Q9NSN8	SNTG1_HUMAN	syntrophin, gamma 1	223					cell communication	cytoplasm|cytoskeleton|nucleus|ruffle membrane|syntrophin complex	actin binding|protein C-terminus binding			NS(1)|breast(1)|endometrium(6)|kidney(3)|large_intestine(6)|lung(36)|ovary(6)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)	66		all_cancers(86;0.00754)|all_epithelial(80;9.76e-05)|Lung NSC(129;0.000865)|all_lung(136;0.00249)|Colorectal(162;0.22)				GTGCCCGGCACAGATTTGAGT	0.473000													59	290					3.40343e-31	5.71776e-31	1	1	0
EDIL3	10085	broad.mit.edu	37	5	83433160	83433160	+	Missense_Mutation	SNP	C	C	A			TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chr5:83433160C>A	ENST00000296591.5	-	5	786	c.368G>T	c.(367-369)tGc>tTc	p.C123F	EDIL3_ENST00000380138.3_Missense_Mutation_p.C113F	NM_005711.3	NP_005702.3	O43854	EDIL3_HUMAN	EGF-like repeats and discoidin I-like domains 3	123	EGF-like 3.				cell adhesion|multicellular organismal development	extracellular region	calcium ion binding|integrin binding			cervix(1)|endometrium(2)|kidney(3)|large_intestine(6)|lung(10)|ovary(1)|prostate(5)|skin(3)	31		Lung NSC(167;0.000121)|all_lung(232;0.000154)|Ovarian(174;0.0425)		OV - Ovarian serous cystadenocarcinoma(54;4.3e-40)|Epithelial(54;4.79e-32)|all cancers(79;1.54e-26)		CTCAACTTCGCATTCATTTAT	0.333000													12	80					1.05317e-09	1.34857e-09	1	1	0
DSCAM	1826	broad.mit.edu	37	21	41725617	41725617	+	Missense_Mutation	SNP	T	T	A			TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chr21:41725617T>A	ENST00000400454.1	-	5	1186	c.709A>T	c.(709-711)Atg>Ttg	p.M237L		NM_001389.3	NP_001380.2	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule	237	Ig-like C2-type 3.				cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(22)|lung(47)|ovary(7)|pancreas(2)|prostate(3)|skin(14)|upper_aerodigestive_tract(6)|urinary_tract(4)	142		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				TGCCCAGCCATGGCTTTGCGA	0.547000													6	28					0	0	1	0	0
ANKRD30B	374860	broad.mit.edu	37	18	14763729	14763729	+	Nonsense_Mutation	SNP	G	G	T			TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chr18:14763729G>T	ENST00000358984.4	+	7	1045	c.865G>T	c.(865-867)Gaa>Taa	p.E289*	ANKRD30B_ENST00000447268.2_Nonsense_Mutation_p.E289*|ANKRD30B_ENST00000579292.1_Intron	NM_001145029.1	NP_001138501.1	Q9BXX2	AN30B_HUMAN	ankyrin repeat domain 30B	289										breast(3)|endometrium(4)|kidney(3)|lung(8)|ovary(1)|prostate(2)|skin(1)	22						ACCCTTGGCGGAAAGAACACC	0.478000													8	22					2.74318e-10	3.57806e-10	1	1	0
EMC2	9694	broad.mit.edu	37	8	109462682	109462682	+	Missense_Mutation	SNP	G	G	T			TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chr8:109462682G>T	ENST00000220853.3	+	3	215	c.180G>T	c.(178-180)atG>atT	p.M60I		NM_014673.3	NP_055488.1			ER membrane protein complex subunit 2																		AACAGGTGATGATTGCAGCAC	0.313000													78	77					9.54843e-35	1.61707e-34	1	1	0
ZNF114	163071	broad.mit.edu	37	19	48789046	48789046	+	Silent	SNP	C	C	T	rs150295509	by1000genomes	TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chr19:48789046C>T	ENST00000595607.1	+	6	659	c.165C>T	c.(163-165)gaC>gaT	p.D55D	ZNF114_ENST00000600687.1_Silent_p.D55D|ZNF114_ENST00000597695.1_Silent_p.D21D|ZNF114_ENST00000315849.1_Silent_p.D55D			Q8NC26	ZN114_HUMAN	zinc finger protein 114	55	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|large_intestine(6)|lung(11)	18		all_epithelial(76;8.01e-05)|all_lung(116;0.000112)|Lung NSC(112;0.000192)|Prostate(7;0.0187)|all_neural(266;0.0228)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;7.56e-05)|all cancers(93;0.000113)|Epithelial(262;0.00962)|GBM - Glioblastoma multiforme(486;0.0153)		AAACCAAAGACGCAACCCCTC	0.428000													12	73					0	0	1	0	0
BRINP3	339479	broad.mit.edu	37	1	190067382	190067382	+	Nonsense_Mutation	SNP	G	G	T			TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chr1:190067382G>T	ENST00000367462.3	-	8	2298	c.2067C>A	c.(2065-2067)taC>taA	p.Y689*	FAM5C_ENST00000484105.1_5'UTR|FAM5C_ENST00000534846.1_Nonsense_Mutation_p.Y587*	NM_199051.1	NP_950252.1	Q76B58	FAM5C_HUMAN		689						extracellular region				NS(1)|breast(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(6)|kidney(8)|large_intestine(18)|lung(98)|ovary(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(7)|urinary_tract(2)	164	Prostate(682;0.198)					GAGTATAGGGGTAGTCCAGCT	0.468000													18	94					2.35188e-11	3.18642e-11	1	1	0
LRP1B	53353	broad.mit.edu	37	2	141116420	141116420	+	Missense_Mutation	SNP	C	C	A	rs150879175	byFrequency	TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chr2:141116420C>A	ENST00000389484.3	-	73	12198	c.11227G>T	c.(11227-11229)Ggt>Tgt	p.G3743C		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	3743	LDL-receptor class A 31.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding	p.G3743S(1)		NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		GAATTGTCACCGCATTCATCA	0.398000										TSP Lung(27;0.18)			59	85					1.88225e-35	3.2136e-35	1	1	0
L3MBTL1	26013	broad.mit.edu	37	20	42169596	42169596	+	Missense_Mutation	SNP	A	A	T			TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chr20:42169596A>T	ENST00000373135.3	+	19	2279	c.2147A>T	c.(2146-2148)cAt>cTt	p.H716L	L3MBTL1_ENST00000418998.1_Missense_Mutation_p.H784L|L3MBTL1_ENST00000373134.1_3'UTR|L3MBTL1_ENST00000444063.1_3'UTR|L3MBTL1_ENST00000427442.2_Missense_Mutation_p.H784L	NM_015478.6	NP_056293.4	Q9Y468	LMBL1_HUMAN	l(3)mbt-like 1 (Drosophila)	0	SAM.				chromatin modification|hemopoiesis|negative regulation of transcription, DNA-dependent|regulation of megakaryocyte differentiation|regulation of mitosis	chromatin|condensed chromosome|nucleoplasm	identical protein binding|methylated histone residue binding|nucleosomal histone binding|SAM domain binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|large_intestine(3)|ovary(1)|skin(2)	7						AGAGTGACCCATGTATCTGGG	0.562000													4	24					0	0	1	0	0
CDH18	1016	broad.mit.edu	37	5	19591255	19591255	+	Missense_Mutation	SNP	T	T	A			TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chr5:19591255T>A	ENST00000507958.1	-	9	1900	c.910A>T	c.(910-912)Acc>Tcc	p.T304S	CDH18_ENST00000274170.4_Missense_Mutation_p.T304S|CDH18_ENST00000502796.1_Missense_Mutation_p.T304S|CDH18_ENST00000382275.1_Missense_Mutation_p.T304S|CDH18_ENST00000511273.1_Missense_Mutation_p.T304S|CDH18_ENST00000506372.1_Missense_Mutation_p.T304S			Q13634	CAD18_HUMAN	cadherin 18, type 2	304	Cadherin 3.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(24)|lung(76)|ovary(5)|prostate(4)|skin(6)|upper_aerodigestive_tract(1)	138	Lung NSC(1;0.00734)|all_lung(1;0.0197)					ATGGAGTAGGTCATGTCAGCA	0.413000													29	51					0	0	1	0	0
TMEM132A	54972	broad.mit.edu	37	11	60704298	60704298	+	Silent	SNP	C	C	T			TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chr11:60704298C>T	ENST00000005286.4	+	11	3147	c.2994C>T	c.(2992-2994)atC>atT	p.I998I	TMEM132A_ENST00000453848.2_Silent_p.I997I	NM_017870.3|NM_178031.2	NP_060340.2|NP_821174.1	Q24JP5	T132A_HUMAN	transmembrane protein 132A	997	Confers cellular localization similar to full-length form (By similarity).					endoplasmic reticulum membrane|Golgi membrane|integral to membrane				breast(1)|cervix(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(14)|ovary(3)|prostate(1)|skin(3)	32						AGGAGGACATCCGCTGGGTGT	0.627000													5	58					0	0	1	0	0
CDHR2	54825	broad.mit.edu	37	5	175995990	175995990	+	Silent	SNP	C	C	T			TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chr5:175995990C>T	ENST00000510636.1	+	5	568	c.294C>T	c.(292-294)tcC>tcT	p.S98S	CDHR2_ENST00000261944.5_Silent_p.S98S|CDHR2_ENST00000506348.1_Silent_p.S98S	NM_001171976.1	NP_001165447.1	Q9BYE9	CDHR2_HUMAN	cadherin-related family member 2	98	Cadherin 1.				homophilic cell adhesion|negative regulation of cell growth	apical plasma membrane|cell junction|integral to membrane	calcium ion binding|protein binding			breast(3)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(4)|large_intestine(8)|liver(1)|lung(23)|ovary(3)|prostate(5)|skin(4)|urinary_tract(1)	56						TCACCATCTCCGTGAGCGACC	0.627000													9	49					0	0	1	0	0
PRMT5	10419	broad.mit.edu	37	14	23398432	23398432	+	Translation_Start_Site	SNP	C	C	T			TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chr14:23398432C>T	ENST00000397441.2	-	1	178	c.3G>A	c.(1-3)atG>atA	p.M1I	PRMT5_ENST00000324366.8_Intron|PRMT5_ENST00000216350.8_Start_Codon_SNP_p.M1I|PRMT5_ENST00000553641.1_5'UTR|PRMT5_ENST00000553897.1_Intron|PRMT5_ENST00000538452.1_5'UTR|PRMT5_ENST00000397440.4_Start_Codon_SNP_p.M1I	NM_001039619.1	NP_001034708.1	O14744	ANM5_HUMAN	protein arginine methyltransferase 5	0					cell proliferation|histone H4-R3 methylation|ncRNA metabolic process|regulation of mitosis|spliceosomal snRNP assembly|transcription, DNA-dependent	cytosol|nucleus	histone-arginine N-methyltransferase activity|protein binding|protein-arginine omega-N symmetric methyltransferase activity|ribonucleoprotein binding			endometrium(4)|kidney(3)|large_intestine(3)|lung(9)|ovary(1)|prostate(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	25	all_cancers(95;2.76e-05)			GBM - Glioblastoma multiforme(265;0.0126)		TCGGACCCCGCATTCCGCTCG	0.632000													18	97					0	0	1	0	0
MYH11	4629	broad.mit.edu	37	16	15809082	15809082	+	Missense_Mutation	SNP	A	A	T			TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chr16:15809082A>T	ENST00000338282.6	-	39	5658	c.5552T>A	c.(5551-5553)cTg>cAg	p.L1851Q	MYH11_ENST00000396324.3_Missense_Mutation_p.L1858Q|MYH11_ENST00000300036.5_Missense_Mutation_p.L1851Q|NDE1_ENST00000342673.5_Intron|NDE1_ENST00000396355.1_Intron|MYH11_ENST00000576790.1_Missense_Mutation_p.L1851Q|NDE1_ENST00000396354.1_Intron|MYH11_ENST00000452625.2_Missense_Mutation_p.L1858Q	NM_022844.2	NP_074035.1	P35749	MYH11_HUMAN	myosin, heavy chain 11, smooth muscle	1851					axon guidance|cardiac muscle fiber development|elastic fiber assembly|skeletal muscle myosin thick filament assembly|smooth muscle contraction	cytosol|melanosome|muscle myosin complex|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			NS(2)|breast(7)|central_nervous_system(1)|endometrium(11)|kidney(5)|large_intestine(34)|liver(1)|lung(37)|ovary(9)|pancreas(1)|prostate(7)|skin(7)|upper_aerodigestive_tract(1)	123						GATTTCCTTCAGCTTCTTGTC	0.592000			T	CBFB	AML								35	65					0	0	1	0	0
NPR3	4883	broad.mit.edu	37	5	32774938	32774938	+	Missense_Mutation	SNP	G	G	T			TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chr5:32774938G>T	ENST00000265074.8	+	4	1527	c.1184G>T	c.(1183-1185)aGa>aTa	p.R395I	NPR3_ENST00000415167.2_Missense_Mutation_p.R395I|NPR3_ENST00000434067.2_Missense_Mutation_p.R179I|NPR3_ENST00000415685.2_Missense_Mutation_p.R179I	NM_000908.3|NM_001204375.1	NP_000899.1|NP_001191304.1	P17342	ANPRC_HUMAN	natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C)	395					osteoclast proliferation|positive regulation of urine volume|regulation of blood pressure|regulation of osteoblast proliferation|skeletal system development	integral to membrane	hormone binding|natriuretic peptide receptor activity			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(2)|large_intestine(5)|lung(12)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	24					Nesiritide(DB04899)	ACTTGGAACAGAACATTTGAA	0.468000													54	87					1.75667e-42	3.04876e-42	1	1	0
COL5A1	1289	broad.mit.edu	37	9	137726876	137726876	+	Silent	SNP	G	G	T			TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chr9:137726876G>T	ENST00000371817.3	+	65	5610	c.5196G>T	c.(5194-5196)cgG>cgT	p.R1732R		NM_000093.3|NM_001278074.1	NP_000084.3|NP_001265003.1	P20908	CO5A1_HUMAN	collagen, type V, alpha 1	1732	Fibrillar collagen NC1.				axon guidance|cell adhesion|collagen biosynthetic process|collagen fibril organization|eye morphogenesis|fibril organization|integrin biosynthetic process|skin development|wound healing, spreading of epidermal cells	collagen type V	heparin binding|integrin binding|platelet-derived growth factor binding|proteoglycan binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(26)|liver(2)|lung(36)|ovary(4)|pancreas(4)|prostate(5)|skin(10)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(4)	115		Myeloproliferative disorder(178;0.0341)		all cancers(34;2.28e-08)|OV - Ovarian serous cystadenocarcinoma(145;6.03e-08)|Epithelial(140;6.4e-08)|GBM - Glioblastoma multiforme(294;0.131)		CCTTCCTGCGGCTGCTGAGCG	0.657000													5	35					1.23904e-05	1.40648e-05	1	1	0
KRAS	3845	broad.mit.edu	37	12	25398284	25398284	+	Missense_Mutation	SNP	C	C	G	rs121913529		TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chr12:25398284C>G	ENST00000311936.3	-	2	226	c.35G>C	c.(34-36)gGt>gCt	p.G12A	KRAS_ENST00000556131.1_Missense_Mutation_p.G12A|KRAS_ENST00000557334.1_Missense_Mutation_p.G12A|KRAS_ENST00000256078.4_Missense_Mutation_p.G12A	NM_004985.3	NP_004976.2	P01116	RASK_HUMAN	Kirsten rat sarcoma viral oncogene homolog	12			G -> A (in a colorectal cancer sample; somatic mutation).|G -> C (in lung carcinoma; somatic mutation).|G -> D (in pancreatic carcinoma, GASC and lung carcinoma; somatic mutation).|G -> R (in lung cancer and bladder cancer; somatic mutation).|G -> S (in lung carcinoma and GASC; somatic mutation).|G -> V (in lung carcinoma, pancreatic carcinoma, colon cancer and GASC; somatic mutation).		activation of MAPKK activity|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	plasma membrane	GTP binding|GTPase activity|protein binding	p.G12D(8562)|p.G12V(5775)|p.G12A(1407)|p.G12F(46)|p.G12L(8)|p.G12I(4)|p.G12E(3)|p.G12W(3)|p.G12Y(2)|p.G12fs*3(1)|p.G12C(1)|p.G12N(1)	UBE2L3/KRAS(2)	NS(6)|adrenal_gland(1)|autonomic_ganglia(3)|biliary_tract(532)|bone(2)|breast(32)|central_nervous_system(14)|cervix(50)|endometrium(411)|eye(4)|gastrointestinal_tract_(site_indeterminate)(7)|genital_tract(1)|haematopoietic_and_lymphoid_tissue(385)|kidney(8)|large_intestine(15267)|liver(29)|lung(3407)|oesophagus(16)|ovary(612)|pancreas(3739)|penis(1)|peritoneum(6)|prostate(96)|salivary_gland(6)|skin(45)|small_intestine(68)|soft_tissue(88)|stomach(207)|testis(17)|thymus(5)|thyroid(159)|upper_aerodigestive_tract(68)|urinary_tract(57)	25349	all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)		OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)			GCCTACGCCACCAGCTCCAAC	0.348000	G12A(KMS28BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(KPNSI9S_AUTONOMIC_GANGLIA)|G12A(MM1S_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(NCIH1573_LUNG)|G12A(NCIH2009_LUNG)|G12A(RERFLCAD1_LUNG)|G12A(RPMI8226_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(SW1116_LARGE_INTESTINE)|G12D(AGS_STOMACH)|G12D(ASPC1_PANCREAS)|G12D(COLO678_LARGE_INTESTINE)|G12D(HEC1A_ENDOMETRIUM)|G12D(HEC50B_ENDOMETRIUM)|G12D(HEYA8_OVARY)|G12D(HPAC_PANCREAS)|G12D(HPAFII_PANCREAS)|G12D(KARPAS620_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KP4_PANCREAS)|G12D(L33_PANCREAS)|G12D(LS180_LARGE_INTESTINE)|G12D(LS513_LARGE_INTESTINE)|G12D(MCAS_OVARY)|G12D(PANC0203_PANCREAS)|G12D(PANC0403_PANCREAS)|G12D(PANC0504_PANCREAS)|G12D(PANC0813_PANCREAS)|G12D(PANC1_PANCREAS)|G12D(PK1_PANCREAS)|G12D(PK59_PANCREAS)|G12D(SKLU1_LUNG)|G12D(SNUC2A_LARGE_INTESTINE)|G12D(SU8686_PANCREAS)|G12D(SUIT2_PANCREAS)|G12D(SW1990_PANCREAS)|G12V(A498_KIDNEY)|G12V(CAPAN2_PANCREAS)|G12V(CFPAC1_PANCREAS)|G12V(COLO668_LUNG)|G12V(CORL23_LUNG)|G12V(DANG_PANCREAS)|G12V(HCC56_LARGE_INTESTINE)|G12V(HUPT4_PANCREAS)|G12V(KP3_PANCREAS)|G12V(LCLC97TM1_LUNG)|G12V(NCIH2444_LUNG)|G12V(NCIH441_LUNG)|G12V(NCIH727_LUNG)|G12V(PANC0327_PANCREAS)|G12V(PATU8902_PANCREAS)|G12V(PATU8988S_PANCREAS)|G12V(QGP1_PANCREAS)|G12V(RCM1_LARGE_INTESTINE)|G12V(RERFLCAD2_LUNG)|G12V(RKN_OVARY)|G12V(SH10TC_STOMACH)|G12V(SHP77_LUNG)|G12V(SNGM_ENDOMETRIUM)|G12V(SW403_LARGE_INTESTINE)|G12V(SW480_LARGE_INTESTINE)|G12V(SW620_LARGE_INTESTINE)|G12V(SW900_LUNG)|G12V(YAPC_PANCREAS)	119	Mis		"""pancreatic, colorectal, lung, thyroid, AML, others"""				Noonan syndrome;Cardiofaciocutaneous syndrome	TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)			3	8					0	0	1	0	0
ZCCHC16	340595	broad.mit.edu	37	X	111698803	111698803	+	Missense_Mutation	SNP	T	T	C			TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chrX:111698803T>C	ENST00000340433.2	+	1	1077	c.847T>C	c.(847-849)Tgc>Cgc	p.C283R		NM_001004308.2	NP_001004308.2	Q6ZR62	ZCH16_HUMAN	zinc finger, CCHC domain containing 16	283							nucleic acid binding|zinc ion binding			cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(16)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	27						GTGCCTCTACTGCAGCCAATC	0.547000													48	22					0	0	1	0	0
ANKEF1	63926	broad.mit.edu	37	20	10023772	10023772	+	Missense_Mutation	SNP	G	G	A			TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chr20:10023772G>A	ENST00000378380.3	+	3	678	c.349G>A	c.(349-351)Gtt>Att	p.V117I	SNAP25-AS1_ENST00000603542.1_RNA|ANKEF1_ENST00000488991.1_3'UTR|SNAP25-AS1_ENST00000421143.2_RNA|ANKEF1_ENST00000378392.1_Missense_Mutation_p.V117I	NM_198798.1	NP_942093.1			ankyrin repeat and EF-hand domain containing 1																		CTCTGCAGGTGTTTTGTTTTA	0.353000													10	41					0	0	1	0	0
DNMT3L	29947	broad.mit.edu	37	21	45679420	45679420	+	Missense_Mutation	SNP	C	C	T			TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chr21:45679420C>T	ENST00000270172.3	-	5	727	c.244G>A	c.(244-246)Gat>Aat	p.D82N	DNMT3L_ENST00000418993.1_Missense_Mutation_p.D82N	NM_013369.3	NP_037501.2	Q9UJW3	DNM3L_HUMAN	DNA (cytosine-5-)-methyltransferase 3-like	82	ADD.				DNA methylation|negative regulation of transcription, DNA-dependent|regulation of gene expression by genetic imprinting|spermatogenesis	cytosol	enzyme activator activity|enzyme binding|metal ion binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|prostate(1)|skin(3)	11				Colorectal(79;0.0165)|READ - Rectum adenocarcinoma(84;0.0781)		AAGAGGGCATCCAGGAACTTG	0.582000													4	57					0	0	1	0	0
NLRP7	199713	broad.mit.edu	37	19	55451528	55451528	+	Missense_Mutation	SNP	G	G	T			TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chr19:55451528G>T	ENST00000588756.1	-	6	1145	c.659C>A	c.(658-660)cCc>cAc	p.P220H	NLRP7_ENST00000328092.5_Missense_Mutation_p.P220H|NLRP7_ENST00000592784.1_Missense_Mutation_p.P220H|NLRP7_ENST00000448121.2_Missense_Mutation_p.P220H|NLRP7_ENST00000590030.1_Missense_Mutation_p.P220H|NLRP7_ENST00000446217.1_Missense_Mutation_p.P248H|NLRP7_ENST00000340844.2_Missense_Mutation_p.P220H			Q8WX94	NALP7_HUMAN	NLR family, pyrin domain containing 7	220	NACHT.						ATP binding			autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(17)|liver(1)|lung(33)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	73				GBM - Glioblastoma multiforme(193;0.0325)		AAAACTGCAGGGGCCCATGCG	0.547000													18	80					2.48551e-13	3.62469e-13	1	1	0
ZFYVE20	64145	broad.mit.edu	37	3	15115625	15115625	+	Silent	SNP	T	T	A			TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chr3:15115625T>A	ENST00000253699.3	-	14	2632	c.2019A>T	c.(2017-2019)gcA>gcT	p.A673A	ZFYVE20_ENST00000476527.2_Silent_p.A673A	NM_022340.2	NP_071735.2	Q9H1K0	RBNS5_HUMAN	zinc finger, FYVE domain containing 20	673	Necessary for the interaction with EHD1.|Necessary for the interaction with RAB5A.				blood coagulation|endosome transport|protein transport	early endosome membrane|plasma membrane	protein binding|zinc ion binding			NS(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(10)|skin(3)|stomach(1)|urinary_tract(2)	26						TCCCTGCCACTGCTTCCTCCT	0.562000													23	149					0	0	1	0	0
ROR2	4920	broad.mit.edu	37	9	94486849	94486849	+	Missense_Mutation	SNP	C	C	G			TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chr9:94486849C>G	ENST00000375708.3	-	9	2125	c.1927G>C	c.(1927-1929)Gcc>Ccc	p.A643P	ROR2_ENST00000550066.1_5'UTR|ROR2_ENST00000375715.1_Missense_Mutation_p.A503P	NM_004560.3	NP_004551.2	Q01974	ROR2_HUMAN	receptor tyrosine kinase-like orphan receptor 2	643	Protein kinase.				negative regulation of cell proliferation|positive regulation of cell migration|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity|Wnt-protein binding			autonomic_ganglia(1)|breast(1)|central_nervous_system(5)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(12)|lung(31)|ovary(3)|prostate(6)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	71						TAGTAATCGGCGGCATACACC	0.567000													12	74					0	0	1	0	0
ZFYVE26	23503	broad.mit.edu	37	14	68272204	68272204	+	Silent	SNP	G	G	A			TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chr14:68272204G>A	ENST00000347230.4	-	7	1287	c.1149C>T	c.(1147-1149)gcC>gcT	p.A383A	ZFYVE26_ENST00000555452.1_Silent_p.A383A	NM_015346.3	NP_056161.2	Q68DK2	ZFY26_HUMAN	zinc finger, FYVE domain containing 26	383					cell cycle|cell death|cytokinesis|double-strand break repair via homologous recombination	centrosome|midbody	metal ion binding|phosphatidylinositol-3-phosphate binding|protein binding			NS(1)|breast(3)|cervix(1)|endometrium(6)|kidney(8)|large_intestine(8)|lung(39)|ovary(12)|pancreas(1)|prostate(7)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)	94				all cancers(60;0.000763)|OV - Ovarian serous cystadenocarcinoma(108;0.0011)|BRCA - Breast invasive adenocarcinoma(234;0.0115)		GCAGCCTCTTGGCTGACTCTA	0.572000													20	67					0	0	1	0	0
PRPF8	10594	broad.mit.edu	37	17	1560029	1560029	+	Missense_Mutation	SNP	C	C	A			TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chr17:1560029C>A	ENST00000572621.1	-	34	5797	c.5532G>T	c.(5530-5532)gaG>gaT	p.E1844D	PRPF8_ENST00000304992.6_Missense_Mutation_p.E1844D			Q6P2Q9	PRP8_HUMAN	pre-mRNA processing factor 8	1844	Involved in interaction with pre-mRNA 5' splice site.					catalytic step 2 spliceosome|nuclear speck|U5 snRNP	protein binding|RNA binding			NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(13)|lung(24)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(5)|urinary_tract(3)	77				UCEC - Uterine corpus endometrioid carcinoma (25;0.0855)		GGGCGGCCACCTCCTCAGCTG	0.512000													12	21					2.61681e-11	3.52264e-11	1	1	0
LOC220729	220729	broad.mit.edu	37	3	197348646	197348646	+	RNA	SNP	T	T	C	rs138265355	by1000genomes	TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chr3:197348646T>C	ENST00000418868.1	-	0	613					NR_003266.2																						TGGGCCTGCCTGCCCTTTCCA	0.532000													5	109					0	0	1	0	0
KIF3A	11127	broad.mit.edu	37	5	132051569	132051569	+	Silent	SNP	G	G	T			TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chr5:132051569G>T	ENST00000378746.4	-	8	1227	c.1009C>A	c.(1009-1011)Cgg>Agg	p.R337R	AC004237.1_ENST00000431165.1_RNA|KIF3A_ENST00000403231.1_Silent_p.R337R|KIF3A_ENST00000378735.1_Silent_p.R337R	NM_007054.5	NP_008985.3	Q9Y496	KIF3A_HUMAN	kinesin family member 3A	337	Kinesin-motor.				blood coagulation|organelle organization|plus-end-directed vesicle transport along microtubule	centrosome|cytosol|kinesin II complex|spindle microtubule	ATP binding|plus-end-directed microtubule motor activity|protein binding	p.R337W(2)		endometrium(1)|kidney(4)|large_intestine(8)|lung(3)|ovary(1)|pancreas(1)|prostate(4)|skin(1)|upper_aerodigestive_tract(2)	25		all_cancers(142;0.0751)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			TTGGCATACCGTAATGTACTG	0.328000													6	14					8.12818e-05	8.75343e-05	1	1	0
GDF10	2662	broad.mit.edu	37	10	48428922	48428922	+	Missense_Mutation	SNP	G	G	T			TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chr10:48428922G>T	ENST00000224605.2	-	2	1229	c.964C>A	c.(964-966)Cag>Aag	p.Q322K		NM_004962.3	NP_004953.1	P55107	BMP3B_HUMAN	growth differentiation factor 10	322					growth|skeletal system development|transforming growth factor beta receptor signaling pathway	extracellular space	cytokine activity|growth factor activity			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(4)|lung(20)|skin(1)	31						GGCCACAGCTGGTGCTTGTGG	0.716000													5	39					8.12818e-05	8.75343e-05	1	1	0
CDK18	5129	broad.mit.edu	37	1	205499786	205499786	+	Missense_Mutation	SNP	A	A	G			TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chr1:205499786A>G	ENST00000360066.2	+	15	1644	c.1343A>G	c.(1342-1344)cAg>cGg	p.Q448R	CDK18_ENST00000429964.2_Missense_Mutation_p.Q448R|CDK18_ENST00000506784.1_Missense_Mutation_p.Q478R|CDK18_ENST00000509056.1_3'UTR	NM_002596.3|NM_212502.2|NM_212503.2	NP_002587.2|NP_997667.1|NP_997668.1	Q07002	CDK18_HUMAN	cyclin-dependent kinase 18	446							ATP binding|cyclin-dependent protein kinase activity|protein binding|signal transducer activity			breast(2)|endometrium(2)|large_intestine(2)|lung(10)|stomach(2)|urinary_tract(1)	19						AAGGAGATCCAGCTCCAGAAG	0.612000													4	54					0	0	1	0	0
SALL3	27164	broad.mit.edu	37	18	76754097	76754097	+	Silent	SNP	G	G	C			TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chr18:76754097G>C	ENST00000536229.3	+	1	2416	c.1707G>C	c.(1705-1707)acG>acC	p.T569T	SALL3_ENST00000537592.2_Silent_p.T702T|SALL3_ENST00000575389.2_Silent_p.T702T			Q9BXA9	SALL3_HUMAN	spalt-like transcription factor 3	702					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(2)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(8)|lung(40)|ovary(4)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	74		Esophageal squamous(42;0.129)|Melanoma(33;0.16)|Prostate(75;0.167)		OV - Ovarian serous cystadenocarcinoma(15;4.69e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0256)		GGACGCACACGGGGGAGCGGC	0.637000													7	31					0	0	1	0	0
MORC1	27136	broad.mit.edu	37	3	108773602	108773602	+	Missense_Mutation	SNP	C	C	A			TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chr3:108773602C>A	ENST00000232603.5	-	14	1385	c.1303G>T	c.(1303-1305)Gtc>Ttc	p.V435F	MORC1_ENST00000483760.1_Missense_Mutation_p.V435F	NM_014429.3	NP_055244.3	Q86VD1	MORC1_HUMAN	MORC family CW-type zinc finger 1	435					cell differentiation|multicellular organismal development|spermatogenesis	nucleus	ATP binding|zinc ion binding			breast(7)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(14)|lung(47)|ovary(3)|prostate(6)|skin(12)|upper_aerodigestive_tract(3)	105						CAGTACTGGACCAAGTACTGT	0.388000													39	69					2.95478e-19	4.56252e-19	1	1	0
NFASC	23114	broad.mit.edu	37	1	204921172	204921172	+	Missense_Mutation	SNP	C	C	A			TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chr1:204921172C>A	ENST00000367172.4	+	5	471	c.143C>A	c.(142-144)gCg>gAg	p.A48E	NFASC_ENST00000404076.1_Missense_Mutation_p.A42E|NFASC_ENST00000404907.1_Missense_Mutation_p.A42E|NFASC_ENST00000360049.4_Missense_Mutation_p.A42E|NFASC_ENST00000339876.6_Missense_Mutation_p.A48E|NFASC_ENST00000513543.1_Missense_Mutation_p.A42E|NFASC_ENST00000401399.1_Missense_Mutation_p.A48E|NFASC_ENST00000403080.1_Missense_Mutation_p.A48E|NFASC_ENST00000367171.4_Missense_Mutation_p.A48E|NFASC_ENST00000338515.6_Missense_Mutation_p.A48E|NFASC_ENST00000338586.6_Missense_Mutation_p.A48E|NFASC_ENST00000367169.4_Missense_Mutation_p.A48E|NFASC_ENST00000367170.4_Missense_Mutation_p.A48E|NFASC_ENST00000539706.1_Missense_Mutation_p.A42E			O94856	NFASC_HUMAN	neurofascin	48	Ig-like C2-type 1.				axon guidance|cell adhesion|myelination|peripheral nervous system development	integral to membrane|node of Ranvier|plasma membrane	protein binding	p.A48V(2)|p.A42V(1)		NS(1)|breast(4)|central_nervous_system(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|liver(1)|lung(24)|ovary(3)|pancreas(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)	81	all_cancers(21;0.0375)|Breast(84;0.0437)|all_epithelial(62;0.171)|Prostate(682;0.19)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.158)			AAGCAGTCAGCGAAGGATCAC	0.577000													17	40					9.16793e-09	1.13921e-08	1	1	0
KCNQ3	3786	broad.mit.edu	37	8	133141656	133141656	+	Silent	SNP	C	C	A			TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chr8:133141656C>A	ENST00000388996.4	-	15	2892	c.2472G>T	c.(2470-2472)tcG>tcT	p.S824S	KCNQ3_ENST00000521134.1_Silent_p.S704S|KCNQ3_ENST00000519445.1_Silent_p.S812S	NM_004519.3	NP_004510.1	O43525	KCNQ3_HUMAN	potassium voltage-gated channel, KQT-like subfamily, member 3	824					axon guidance|synaptic transmission	voltage-gated potassium channel complex	voltage-gated potassium channel activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(21)|lung(22)|ovary(2)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	70	Esophageal squamous(12;0.00507)|Ovarian(258;0.00579)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000311)			TCATCCAGCTCGACCCCCCAT	0.622000													44	46					9.39024e-22	1.4939e-21	1	1	0
TRRAP	8295	broad.mit.edu	37	7	98490104	98490104	+	Missense_Mutation	SNP	C	C	T			TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chr7:98490104C>T	ENST00000359863.4	+	5	528	c.319C>T	c.(319-321)Cgt>Tgt	p.R107C	TRRAP_ENST00000446306.3_Missense_Mutation_p.R107C|TRRAP_ENST00000355540.3_Missense_Mutation_p.R107C	NM_001244580.1	NP_001231509.1	Q9Y4A5	TRRAP_HUMAN	transformation/transcription domain-associated protein	107					histone deubiquitination|histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|PCAF complex|STAGA complex|transcription factor TFTC complex	phosphotransferase activity, alcohol group as acceptor|protein binding|transcription cofactor activity			NS(3)|breast(1)|central_nervous_system(10)|endometrium(16)|kidney(7)|large_intestine(36)|liver(1)|lung(54)|ovary(10)|pancreas(1)|prostate(8)|skin(16)|stomach(5)|upper_aerodigestive_tract(6)|urinary_tract(2)	176	all_cancers(62;6.96e-09)|all_epithelial(64;4.86e-09)|Lung NSC(181;0.01)|all_lung(186;0.016)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)			CGAACATCTTCGTCCTCACAC	0.338000													21	87					0	0	1	0	0
CABS1	85438	broad.mit.edu	37	4	71201633	71201633	+	Nonsense_Mutation	SNP	G	G	T			TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chr4:71201633G>T	ENST00000273936.4	+	1	936	c.877G>T	c.(877-879)Gag>Tag	p.E293*		NM_033122.3	NP_149113.3	Q96KC9	CABS1_HUMAN	calcium-binding protein, spermatid-specific 1	293						flagellum	calcium ion binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(12)|ovary(4)|pancreas(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	33						AGAAACTACCGAGGGAGCCAG	0.423000													18	73					4.35082e-09	5.50405e-09	1	1	0
WBSCR17	64409	broad.mit.edu	37	7	70597938	70597938	+	Missense_Mutation	SNP	C	C	A			TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chr7:70597938C>A	ENST00000333538.5	+	1	784	c.150C>A	c.(148-150)aaC>aaA	p.N50K		NM_022479.1	NP_071924.1	Q6IS24	GLTL3_HUMAN	Williams-Beuren syndrome chromosome region 17	50						Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			NS(5)|breast(2)|central_nervous_system(1)|endometrium(7)|kidney(7)|large_intestine(22)|lung(45)|ovary(2)|pancreas(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)	100		all_cancers(73;0.2)|Lung NSC(55;0.094)|all_lung(88;0.125)				AGGTGGCCAACCTCAGCGCGC	0.687000													12	55					3.07112e-06	3.5436e-06	1	1	0
RAPGEF2	9693	broad.mit.edu	37	4	160252979	160252979	+	Silent	SNP	G	G	T			TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chr4:160252979G>T	ENST00000264431.4	+	9	1709	c.1290G>T	c.(1288-1290)ggG>ggT	p.G430G		NM_014247.2	NP_055062.1	Q9Y4G8	RPGF2_HUMAN	Rap guanine nucleotide exchange factor (GEF) 2	430	PDZ.				cAMP-mediated signaling|MAPKKK cascade|small GTPase mediated signal transduction	integral to plasma membrane|intracellular	calcium ion binding|diacylglycerol binding|Rap GTPase activator activity|Rap guanyl-nucleotide exchange factor activity|signal transducer activity			breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|liver(1)|lung(29)|ovary(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	70	all_hematologic(180;0.24)			COAD - Colon adenocarcinoma(41;0.0817)		TGAAACGGGGGGATCAGGTAT	0.363000													40	70					2.45108e-15	3.67662e-15	1	1	0
LRP1B	53353	broad.mit.edu	37	2	141215095	141215095	+	Missense_Mutation	SNP	G	G	T			TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chr2:141215095G>T	ENST00000389484.3	-	61	10722	c.9751C>A	c.(9751-9753)Ctg>Atg	p.L3251M		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	3251					protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		GAGTAAATCAGTGAGAGTCTG	0.403000										TSP Lung(27;0.18)			21	131					1.50039e-11	2.05936e-11	1	1	0
ZNF345	25850	broad.mit.edu	37	19	37368087	37368087	+	Missense_Mutation	SNP	G	G	A			TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chr19:37368087G>A	ENST00000529555.1	+	2	1143	c.355G>A	c.(355-357)Gaa>Aaa	p.E119K	ZNF345_ENST00000420450.1_Missense_Mutation_p.E119K|ZNF345_ENST00000432005.2_Intron|ZNF345_ENST00000526123.1_Intron|ZNF345_ENST00000589046.1_Missense_Mutation_p.E119K			Q14585	ZN345_HUMAN	zinc finger protein 345	119					negative regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase III promoter|transcription from RNA polymerase II promoter|transcription from RNA polymerase III promoter	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(13)|lung(5)|ovary(2)|prostate(1)	24	Esophageal squamous(110;0.183)		COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			GAAGCCTTTTGAATGTAAAGA	0.428000													8	55					0	0	1	0	0
PRPF19	27339	broad.mit.edu	37	11	60670077	60670077	+	Missense_Mutation	SNP	G	G	A			TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chr11:60670077G>A	ENST00000227524.4	-	5	645	c.440C>T	c.(439-441)cCa>cTa	p.P147L		NM_014502.4	NP_055317.1	Q9UMS4	PRP19_HUMAN	pre-mRNA processing factor 19	147					DNA repair|protein polyubiquitination|spliceosome assembly	catalytic step 2 spliceosome|nuclear speck|spindle|ubiquitin ligase complex	DNA binding|identical protein binding|ubiquitin-ubiquitin ligase activity			haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(10)|ovary(1)|prostate(1)|urinary_tract(1)	22						TTGGGAACTTGGCACAGCCTG	0.512000													13	49					0	0	1	0	0
DOK7	285489	broad.mit.edu	37	4	3494877	3494877	+	Silent	SNP	C	C	T			TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chr4:3494877C>T	ENST00000340083.5	+	7	1229	c.1164C>T	c.(1162-1164)tgC>tgT	p.C388C	DOK7_ENST00000512714.1_3'UTR|DOK7_ENST00000507039.1_3'UTR|DOK7_ENST00000389653.2_Silent_p.C388C	NM_173660.4	NP_775931.3	Q18PE1	DOK7_HUMAN	docking protein 7	388					positive regulation of protein tyrosine kinase activity	cell junction|synapse	insulin receptor binding|protein kinase binding			kidney(1)|large_intestine(1)|skin(2)|upper_aerodigestive_tract(1)	5				UCEC - Uterine corpus endometrioid carcinoma (64;0.163)		TGTGCACCTGCCTGCCCGGGA	0.697000													3	7					0	0	1	0	0
PSG6	5675	broad.mit.edu	37	19	43414735	43414735	+	Missense_Mutation	SNP	G	G	A			TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chr19:43414735G>A	ENST00000187910.2	-	3	768	c.703C>T	c.(703-705)Ctc>Ttc	p.L235F	PSG6_ENST00000402603.4_Missense_Mutation_p.L235F|PSG6_ENST00000292125.2_Missense_Mutation_p.L235F	NM_001031850.3	NP_001027020.1			pregnancy specific beta-1-glycoprotein 6											central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(3)|lung(19)|ovary(1)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)	44		Prostate(69;0.00899)				TACTCACGGAGGAGATTCAGG	0.522000													109	262					0	0	1	0	0
CTBP1	1487	broad.mit.edu	37	4	1231989	1231989	+	Silent	SNP	C	C	A			TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chr4:1231989C>A	ENST00000510568.1	-	2	735	c.144G>T	c.(142-144)acG>acT	p.T48T	CTBP1_ENST00000382952.3_Silent_p.T48T|CTBP1_ENST00000290921.6_Silent_p.T59T|CTBP1_ENST00000515690.1_5'UTR			Q13363	CTBP1_HUMAN	C-terminal binding protein 1	59	Interaction with GLIS2 1 (By similarity).				interspecies interaction between organisms|negative regulation of cell proliferation|negative regulation of histone H4 acetylation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of histone deacetylation|protein phosphorylation|regulation of cell cycle|regulation of transcription by chromatin organization|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|viral genome replication|white fat cell differentiation	cytoplasm|transcriptional repressor complex	NAD binding|oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor|protein C-terminus binding|protein domain specific binding|transcription factor binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(2)|ovary(1)|skin(1)|urinary_tract(1)	8			OV - Ovarian serous cystadenocarcinoma(23;0.00818)	Colorectal(103;0.2)		GGATCTCCTGCGTGGACTGCG	0.682000													14	86					2.31682e-05	2.58794e-05	1	1	0
BRINP3	339479	broad.mit.edu	37	1	190234085	190234085	+	Silent	SNP	C	C	T	rs141418514		TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chr1:190234085C>T	ENST00000367462.3	-	4	759	c.528G>A	c.(526-528)acG>acA	p.T176T	RP11-547I7.1_ENST00000452178.1_RNA|FAM5C_ENST00000484105.1_5'UTR|FAM5C_ENST00000534846.1_Silent_p.T74T	NM_199051.1	NP_950252.1	Q76B58	FAM5C_HUMAN		176						extracellular region				NS(1)|breast(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(6)|kidney(8)|large_intestine(18)|lung(98)|ovary(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(7)|urinary_tract(2)	164	Prostate(682;0.198)					GCTGATGTAGCGTCTCCAGAG	0.473000													16	100					0	0	1	0	0
UBAP1	51271	broad.mit.edu	37	9	34251520	34251520	+	Missense_Mutation	SNP	G	G	A			TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chr9:34251520G>A	ENST00000536252.1	+	8	1897	c.1499G>A	c.(1498-1500)gGa>gAa	p.G500E	UBAP1_ENST00000545103.1_Missense_Mutation_p.G564E|UBAP1_ENST00000297661.4_Missense_Mutation_p.G500E|UBAP1_ENST00000379186.4_Missense_Mutation_p.G439E|UBAP1_ENST00000540348.1_Missense_Mutation_p.G500E|UBAP1_ENST00000359544.2_Missense_Mutation_p.G500E|UBAP1_ENST00000543944.1_Missense_Mutation_p.G536E	NM_001171203.2	NP_001164674.1	Q9NZ09	UBAP1_HUMAN	ubiquitin associated protein 1	500						cytoplasm				endometrium(4)|kidney(2)|lung(6)|upper_aerodigestive_tract(1)	13			LUSC - Lung squamous cell carcinoma(29;0.00272)			GCTCGGGCAGGAGCCAGCTGA	0.557000													7	35					0	0	1	0	0
FBN2	2201	broad.mit.edu	37	5	127704902	127704902	+	Missense_Mutation	SNP	A	A	T			TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chr5:127704902A>T	ENST00000508053.1	-	22	3195	c.2221T>A	c.(2221-2223)Tgc>Agc	p.C741S	FBN2_ENST00000262464.4_Missense_Mutation_p.C741S|FBN2_ENST00000511489.1_5'UTR|FBN2_ENST00000508989.1_Missense_Mutation_p.C708S			P35556	FBN2_HUMAN	fibrillin 2	741	TB 3.				bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			NS(1)|autonomic_ganglia(1)|biliary_tract(1)|breast(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(37)|liver(1)|lung(89)|ovary(9)|pancreas(2)|prostate(6)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	197		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)		CATGGCTGGCAGGGTTCTCCA	0.463000													13	49					0	0	1	0	0
SNHG14	104472715	broad.mit.edu	37	15	25324268	25324268	+	RNA	SNP	G	G	T			TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chr15:25324268G>T	ENST00000549804.2	+	0	1377				SNORD116-13_ENST00000384408.1_RNA																							TGGGAACTCTGTACTATCATC	0.433000													33	73					7.83172e-31	1.30529e-30	1	1	0
OR1M1	125963	broad.mit.edu	37	19	9204165	9204165	+	Missense_Mutation	SNP	T	T	A			TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chr19:9204165T>A	ENST00000429566.3	+	1	311	c.245T>A	c.(244-246)cTg>cAg	p.L82Q		NM_001004456.1	NP_001004456.1	Q8NGA1	OR1M1_HUMAN	olfactory receptor, family 1, subfamily M, member 1	82					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(4)|large_intestine(3)|lung(17)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	32						CCTAAGATGCTGGTGAGCCTT	0.522000													16	60					0	0	1	0	0
NCKAP5	344148	broad.mit.edu	37	2	133541210	133541210	+	Silent	SNP	T	T	C			TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chr2:133541210T>C	ENST00000409261.1	-	14	3547	c.3174A>G	c.(3172-3174)caA>caG	p.Q1058Q	NCKAP5_ENST00000317721.6_Silent_p.Q1058Q|NCKAP5_ENST00000409213.1_Intron|NCKAP5_ENST00000405974.3_Intron	NM_207363.2	NP_997246.2	O14513	NCKP5_HUMAN	NCK-associated protein 5	1058							protein binding			NS(4)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(29)|lung(51)|prostate(5)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	118						CTATGTCCCTTTGTGGGGTCC	0.532000													78	81					0	0	1	0	0
TAF7	6879	broad.mit.edu	37	5	140698953	140698953	+	Missense_Mutation	SNP	C	C	A			TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chr5:140698953C>A	ENST00000313368.5	-	1	1377	c.659G>T	c.(658-660)cGg>cTg	p.R220L		NM_005642.2	NP_005633.2	Q15545	TAF7_HUMAN	TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 55kDa	220					negative regulation of histone acetylation|negative regulation of protein kinase activity|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|spermine transport|transcription initiation from RNA polymerase II promoter	Golgi apparatus|MLL1 complex|transcription factor TFIID complex|transcription factor TFTC complex	histone acetyltransferase binding|thyroid hormone receptor binding|transcription coactivator activity|transcription regulatory region DNA binding|vitamin D receptor binding			central_nervous_system(2)|endometrium(2)|large_intestine(2)|lung(5)|skin(1)	12			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GAATATCTCCCGAAGCTCATC	0.458000													15	90					2.35188e-11	3.18642e-11	1	1	0
SDCCAG8	10806	broad.mit.edu	37	1	243507521	243507521	+	Missense_Mutation	SNP	G	G	T			TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chr1:243507521G>T	ENST00000366541.3	+	12	1479	c.1361G>T	c.(1360-1362)tGt>tTt	p.C454F	SDCCAG8_ENST00000343783.6_Missense_Mutation_p.C309F|SDCCAG8_ENST00000355875.4_Missense_Mutation_p.C411F	NM_006642.3	NP_006633.1	Q86SQ7	SDCG8_HUMAN	serologically defined colon cancer antigen 8	454	Sufficient for homodimerization (By similarity).				establishment of cell polarity|G2/M transition of mitotic cell cycle|tube formation	cell-cell junction|centriole|cytosol	protein binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(17)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29	all_cancers(71;0.000545)|all_epithelial(71;0.000509)|all_lung(81;0.0821)|Ovarian(71;0.0919)|all_neural(11;0.101)|Breast(184;0.218)	all_cancers(173;0.00395)	all cancers(7;1.58e-07)|GBM - Glioblastoma multiforme(7;5.12e-06)|OV - Ovarian serous cystadenocarcinoma(106;0.00392)	COAD - Colon adenocarcinoma(196;0.145)		TAACAGGTGTGTGGAGAAATG	0.428000													18	51					7.45023e-12	1.04303e-11	1	1	0
FKBP11	51303	broad.mit.edu	37	12	49318378	49318378	+	Silent	SNP	C	C	T			TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chr12:49318378C>T	ENST00000550765.1	-	3	647	c.249G>A	c.(247-249)ctG>ctA	p.L83L	CCDC65_ENST00000266984.5_Intron|FKBP11_ENST00000552878.1_Silent_p.L83L|AC073610.5_ENST00000537495.1_Intron|FKBP11_ENST00000453172.2_Silent_p.L83L|ARF3_ENST00000398092.4_Intron|FKBP11_ENST00000444214.2_5'UTR	NM_016594.2	NP_057678.1	Q9NYL4	FKB11_HUMAN	FK506 binding protein 11, 19 kDa	83	PPIase FKBP-type.				protein folding	integral to membrane	FK506 binding|peptidyl-prolyl cis-trans isomerase activity			kidney(1)|large_intestine(3)|lung(1)	5						GTTCTATAACCAGAGGGTCTC	0.527000											OREG0021773	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	71	43					0	0	1	0	0
USP14	9097	broad.mit.edu	37	18	211166	211166	+	Missense_Mutation	SNP	G	G	A			TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chr18:211166G>A	ENST00000261601.6	+	16	1458	c.1367G>A	c.(1366-1368)aGc>aAc	p.S456N	USP14_ENST00000383589.2_Missense_Mutation_p.S410N|USP14_ENST00000582707.1_Missense_Mutation_p.S421N|USP14_ENST00000400266.3_Missense_Mutation_p.S445N	NM_005151.3	NP_005142.1	P54578	UBP14_HUMAN	ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase)	456					regulation of chemotaxis|regulation of proteasomal protein catabolic process|ubiquitin-dependent protein catabolic process	cell surface|cytoplasmic membrane-bounded vesicle|plasma membrane|proteasome complex	cysteine-type endopeptidase activity|endopeptidase inhibitor activity|proteasome binding|tRNA guanylyltransferase activity|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			endometrium(1)|large_intestine(1)|lung(5)|ovary(2)|skin(2)	11		all_cancers(4;0.0896)|Myeloproliferative disorder(11;0.0412)				GACAAAGTCAGCATCGTAACA	0.408000													7	39					0	0	1	0	0
LPHN2	23266	broad.mit.edu	37	1	82431848	82431848	+	Silent	SNP	C	C	G			TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chr1:82431848C>G	ENST00000370728.1	+	14	2757	c.2112C>G	c.(2110-2112)gtC>gtG	p.V704V	LPHN2_ENST00000370725.1_Silent_p.V704V|LPHN2_ENST00000370727.1_Silent_p.V704V|LPHN2_ENST00000359929.3_Silent_p.V691V|LPHN2_ENST00000370715.1_Silent_p.V691V|LPHN2_ENST00000370730.1_Silent_p.V704V|LPHN2_ENST00000271029.4_Silent_p.V704V|LPHN2_ENST00000469377.2_Intron|LPHN2_ENST00000370713.1_Silent_p.V691V|LPHN2_ENST00000370723.1_Silent_p.V691V|LPHN2_ENST00000335786.5_Silent_p.V704V|LPHN2_ENST00000394879.1_Silent_p.V691V|LPHN2_ENST00000370717.2_Silent_p.V704V|LPHN2_ENST00000370721.1_Silent_p.V629V|LPHN2_ENST00000319517.6_Silent_p.V691V			O95490	LPHN2_HUMAN	latrophilin 2	704					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|latrotoxin receptor activity|sugar binding			NS(3)|breast(6)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(18)|liver(2)|lung(37)|ovary(3)|pancreas(1)|prostate(3)|skin(22)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(5)	119				all cancers(265;0.00142)|Epithelial(280;0.00829)|OV - Ovarian serous cystadenocarcinoma(397;0.077)|STAD - Stomach adenocarcinoma(256;0.248)		CAAATACCGTCAAACAGAACA	0.388000													23	52					0	0	1	0	0
ZCCHC11	23318	broad.mit.edu	37	1	52940508	52940508	+	Frame_Shift_Del	DEL	C	C	-			TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chr1:52940508delC	ENST00000371544.3	-	13	2985	c.2723delG	c.(2722-2724)gcfs	p.G908fs	ZCCHC11_ENST00000371541.1_5'UTR|ZCCHC11_ENST00000257177.4_Frame_Shift_Del_p.G908fs	NM_001009881.2|NM_015269.2	NP_001009881.1|NP_056084.1	Q5TAX3	TUT4_HUMAN	zinc finger, CCHC domain containing 11	908					miRNA catabolic process|pre-miRNA processing|RNA 3'-end processing|stem cell maintenance	cytoplasm|nucleolus	nucleic acid binding|protein binding|RNA uridylyltransferase activity|zinc ion binding			NS(2)|breast(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(15)|lung(17)|ovary(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	58						TCCTACCTTGCCAGAGGTTAA	0.313													7	37	---	---	---	---					
CEP350	9857	broad.mit.edu	37	1	180065064	180065067	+	Splice_Site	DEL	AGGT	AGGT	-			TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chr1:180065064_180065067delAGGT	ENST00000367607.3	+	35	9336_9337	c.8919_splice	c.e35+1	p.2973_splice	CEP350_ENST00000490141.1_3'UTR	NM_014810.4	NP_055625.4	Q5VT06	CE350_HUMAN	centrosomal protein 350kDa	2973						centrosome|nucleus|spindle				central_nervous_system(1)|endometrium(9)|kidney(4)|large_intestine(7)|lung(35)|ovary(4)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	66						GTCTACAAACAGGTAGGTGAAATA	0.338													7	27	---	---	---	---					
NR5A2	2494	broad.mit.edu	37	1	200090010	200090011	+	Frame_Shift_Ins	INS	-	-	C			TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chr1:200090010_200090011insC	ENST00000367362.3	+	7	1551_1552	c.1305_1306insC	c.(1303-1308)gtcaaafs	p.K436fs	NR5A2_ENST00000236914.3_Frame_Shift_Ins_p.K390fs|NR5A2_ENST00000544748.1_Frame_Shift_Ins_p.K364fs	NM_001276464.1|NM_205860.1	NP_001263393.1|NP_995582.1	O00482	NR5A2_HUMAN	nuclear receptor subfamily 5, group A, member 2	436					embryo development|positive regulation of viral genome replication|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	cytoplasm|nucleoplasm	lipid binding|protein binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|steroid hormone receptor activity|transcription regulatory region DNA binding|zinc ion binding	p.A436S(1)		cervix(1)|endometrium(1)|kidney(3)|large_intestine(6)|lung(15)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	31	Prostate(682;0.19)					AGGAGTTAGTGGCAAAACTTCG	0.426													11	90	---	---	---	---					
IKZF2	22807	broad.mit.edu	37	2	213878652	213878653	+	Frame_Shift_Ins	INS	-	-	GA			TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chr2:213878652_213878653insGA	ENST00000457361.1	-	7	886_887	c.718_719insTC	c.(718-720)tatfs	p.Y240fs	IKZF2_ENST00000374327.4_Frame_Shift_Ins_p.Y95fs|IKZF2_ENST00000374319.4_Frame_Shift_Ins_p.Y214fs|IKZF2_ENST00000342002.2_Frame_Shift_Ins_p.Y246fs|IKZF2_ENST00000434687.1_Frame_Shift_Ins_p.Y240fs|IKZF2_ENST00000413091.3_3'UTR|IKZF2_ENST00000451136.2_Frame_Shift_Ins_p.Y168fs|IKZF2_ENST00000421754.2_Intron	NM_016260.2	NP_057344.2	Q9UKS7	IKZF2_HUMAN	IKAROS family zinc finger 2 (Helios)	240					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|cervix(1)|endometrium(1)|large_intestine(7)|lung(7)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	23		Esophageal squamous(248;0.0559)|Renal(323;0.218)		UCEC - Uterine corpus endometrioid carcinoma (47;0.214)|Epithelial(149;2.97e-07)|all cancers(144;1.53e-05)|LUSC - Lung squamous cell carcinoma(224;0.00599)|Lung(261;0.00792)		ATCTTCCATAGGAGGTACTATA	0.371													27	48	---	---	---	---					
CMSS1	84319	broad.mit.edu	37	3	99881242	99881243	+	Frame_Shift_Ins	INS	-	-	T			TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chr3:99881242_99881243insT	ENST00000421999.2	+	4	467_468	c.321_322insT	c.(319-324)cgtggtfs	p.G108fs	CMSS1_ENST00000489081.1_Frame_Shift_Ins_p.G90fs	NM_032359.3	NP_115735.2			cms1 ribosomal small subunit homolog (yeast)																		GCAGCAGACGCTTGGTGATTGA	0.391													37	60	---	---	---	---					
ZDHHC11	79844	broad.mit.edu	37	5	840719	840720	+	Frame_Shift_Ins	INS	-	-	G			TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chr5:840719_840720insG	ENST00000283441.8	-	5	1057_1058	c.674_675insC	c.(673-675)cgtfs	p.R225fs	ZDHHC11_ENST00000424784.2_Frame_Shift_Ins_p.R225fs|ZDHHC11_ENST00000511539.1_Frame_Shift_Ins_p.R12fs|ZDHHC11_ENST00000503758.2_5'UTR	NM_024786.2	NP_079062.1	Q9H8X9	ZDH11_HUMAN	zinc finger, DHHC-type containing 11	225						integral to membrane	acyltransferase activity|zinc ion binding	p.P225P(2)		haematopoietic_and_lymphoid_tissue(1)|liver(1)|lung(10)|pancreas(1)|prostate(5)|skin(2)|urinary_tract(1)	21			Epithelial(17;0.000445)|all cancers(22;0.00176)|OV - Ovarian serous cystadenocarcinoma(19;0.00227)|Lung(60;0.0863)			GCACCTGCACCGGGAACAGGGG	0.584													59	858	---	---	---	---					
SND1	27044	broad.mit.edu	37	7	127342520	127342520	+	Frame_Shift_Del	DEL	G	G	-			TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chr7:127342520delG	ENST00000354725.3	+	6	815	c.621delG	c.(619-621)gtfs	p.V208fs		NM_014390.2	NP_055205.2	Q7KZF4	SND1_HUMAN	staphylococcal nuclease and tudor domain containing 1	208	TNase-like 2.				gene silencing by RNA|interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription, DNA-dependent	melanosome|nucleus|RNA-induced silencing complex	nuclease activity|nucleic acid binding|protein binding|transcription cofactor activity			central_nervous_system(1)|endometrium(8)|kidney(1)|large_intestine(9)|lung(15)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	41						ACGGCAGTGTGGTCAGGGCCC	0.493													22	85	---	---	---	---					
KIAA2026	158358	broad.mit.edu	37	9	5968617	5968618	+	Frame_Shift_Del	DEL	CT	CT	-			TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chr9:5968617_5968618delCT	ENST00000399933.3	-	3	1612_1613	c.1613_1614delAG	c.(1612-1614)gfs	p.E538fs	KIAA2026_ENST00000381461.2_Frame_Shift_Del_p.E538fs	NM_001017969.2	NP_001017969.2	Q5HYC2	K2026_HUMAN	KIAA2026	538										breast(6)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(11)|lung(15)|ovary(2)|prostate(2)|skin(1)	46		Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.00155)|Lung(218;0.124)		TATTTTCCTGCTCTTTCTTGAA	0.371													14	84	---	---	---	---					
ZWINT	11130	broad.mit.edu	37	10	58118594	58118594	+	Frame_Shift_Del	DEL	C	C	-			TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chr10:58118594delC	ENST00000373944.3	-	6	633	c.595delG	c.(595-597)cafs	p.A199fs	ZWINT_ENST00000460654.1_5'UTR|ZWINT_ENST00000395405.1_Frame_Shift_Del_p.A199fs|ZWINT_ENST00000318387.2_Frame_Shift_Del_p.A79fs|ZWINT_ENST00000361148.6_Intron			O95229	ZWINT_HUMAN	ZW10 interacting kinetochore protein	199					cell division|establishment of localization in cell|mitotic cell cycle checkpoint|mitotic prometaphase|mitotic sister chromatid segregation|phosphatidylinositol-mediated signaling|spindle organization	condensed chromosome kinetochore|cytosol|nucleus	protein N-terminus binding			NS(2)|breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(10)|prostate(1)	20						TCCTGTTCTGCCTGCTGCTTC	0.537													33	106	---	---	---	---					
CRY1	1407	broad.mit.edu	37	12	107486580	107486580	+	Splice_Site	DEL	A	A	-			TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chr12:107486580delA	ENST00000008527.5	-	1	1026		c.e1+1		CRY1_ENST00000550633.1_Splice_Site	NM_004075.3	NP_004066.1	Q16526	CRY1_HUMAN	cryptochrome 1 (photolyase-like)						DNA repair|protein-chromophore linkage|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	blue light photoreceptor activity|DNA photolyase activity|double-stranded DNA binding|nucleotide binding|protein binding			NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(11)|ovary(3)|skin(1)	29						CTTGTGACTCACCGCCACCTG	0.542											OREG0022082	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	9	12	---	---	---	---					
HIF3A	64344	broad.mit.edu	37	19	46800336	46800350	+	Translation_Start_Site	DEL	GGCGCTGGGGCTGCA	GGCGCTGGGGCTGCA	-	rs112781848		TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chr19:46800336_46800350delGGCGCTGGGGCTGCA	ENST00000377670.4	+	0	34_48					NM_152795.3	NP_690008.2	Q9Y2N7	HIF3A_HUMAN	hypoxia inducible factor 3, alpha subunit						regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|signal transducer activity			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(7)|lung(14)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)	33		Ovarian(192;0.00965)|all_neural(266;0.0887)		OV - Ovarian serous cystadenocarcinoma(262;0.00204)|all cancers(93;0.0107)|GBM - Glioblastoma multiforme(486;0.0489)|Epithelial(262;0.136)		GGCGAGCCATGGCGCTGGGGCTGCAGCGCGCAAGG	0.721													7	77	---	---	---	---					
POLD1	5424	broad.mit.edu	37	19	50919910	50919910	+	Frame_Shift_Del	DEL	G	G	-			TCGA-86-8359-01A-11D-2323-08	TCGA-86-8359-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ad3037b7-368c-4f3b-846c-8c7d22ed5029	64ff45a3-4800-4868-923e-783abc7364ed	g.chr19:50919910delG	ENST00000440232.2	+	24	3050	c.2997delG	c.(2995-2997)gtfs	p.V999fs	POLD1_ENST00000599857.1_Frame_Shift_Del_p.V999fs|POLD1_ENST00000595904.1_Frame_Shift_Del_p.V1025fs	NM_001256849.1|NM_002691.3	NP_001243778.1|NP_002682.2	P28340	DPOD1_HUMAN	polymerase (DNA directed), delta 1, catalytic subunit	999					base-excision repair, gap-filling|DNA replication proofreading|DNA replication, removal of RNA primer|DNA synthesis involved in DNA repair|nucleotide-excision repair, DNA gap filling|regulation of mitotic cell cycle|response to UV|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	delta DNA polymerase complex|nucleoplasm|nucleotide-excision repair complex	3'-5'-exodeoxyribonuclease activity|chromatin binding|DNA binding|DNA-directed DNA polymerase activity|metal ion binding|nucleotide binding|protein binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(8)|kidney(4)|large_intestine(6)|lung(8)|ovary(3)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	39		all_neural(266;0.0571)		OV - Ovarian serous cystadenocarcinoma(262;0.00794)|GBM - Glioblastoma multiforme(134;0.0195)		CGGGCAAGGTGGGCGGCCTCC	0.711								DNA polymerases (catalytic subunits)					2	4	---	---	---	---