Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
IRGC	56269	broad.mit.edu	37	19	44223786	44223786	+	Missense_Mutation	SNP	G	G	T			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr19:44223786G>T	ENST00000244314.5	+	2	1275	c.1076G>T	c.(1075-1077)cGc>cTc	p.R359L		NM_019612.3	NP_062558.1	Q6NXR0	IIGP5_HUMAN	immunity-related GTPase family, cinema	359						membrane	GTP binding|hydrolase activity, acting on acid anhydrides			central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(16)|ovary(1)|prostate(1)|skin(2)	25		Prostate(69;0.0435)				CGGGTGGCCCGCGCCTTTGAG	0.657000													8	14					4.68919e-08	5.77841e-08	0.361761	1	0
CORO2B	10391	broad.mit.edu	37	15	69003979	69003979	+	Silent	SNP	G	G	T			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr15:69003979G>T	ENST00000543950.1	+	5	921	c.567G>T	c.(565-567)ctG>ctT	p.L189L	CORO2B_ENST00000261861.5_Silent_p.L189L|CORO2B_ENST00000540068.1_Silent_p.L189L|CORO2B_ENST00000566799.1_Silent_p.L194L	NM_001190457.1	NP_001177386.1	Q9UQ03	COR2B_HUMAN	coronin, actin binding protein, 2B	194					actin cytoskeleton organization	actin cytoskeleton|cytoplasm|membrane	actin filament binding			kidney(3)|large_intestine(13)|lung(11)|ovary(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	36						ACGGCAGCCTGCTCACCACCA	0.552000													7	46					5.18039e-06	6.1419e-06	0.278610	1	0
CDH19	28513	broad.mit.edu	37	18	64172343	64172343	+	Silent	SNP	G	G	A			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr18:64172343G>A	ENST00000262150.2	-	12	2317	c.2025C>T	c.(2023-2025)agC>agT	p.S675S	CDH19_ENST00000540086.1_3'UTR	NM_021153.2	NP_066976.1	Q9H159	CAD19_HUMAN	cadherin 19, type 2	675					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(13)|lung(22)|ovary(1)|prostate(3)|skin(7)	61		Esophageal squamous(42;0.0132)				TGATCTCAGCGCTTGTGGTTT	0.478000													8	57					0	0	0.307466	0	0
COL4A6	1288	broad.mit.edu	37	X	107554031	107554031	+	Missense_Mutation	SNP	C	C	T			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chrX:107554031C>T	ENST00000334504.7	-	3	324	c.91G>A	c.(91-93)Ggg>Agg	p.G31R	COL4A6_ENST00000545689.1_Missense_Mutation_p.G31R|COL4A6_ENST00000538570.1_Missense_Mutation_p.G31R|COL4A6_ENST00000372216.4_Missense_Mutation_p.G32R|COL4A6_ENST00000461897.1_5'UTR|COL4A6_ENST00000394872.2_Missense_Mutation_p.G31R	NM_033641.2	NP_378667.1	Q14031	CO4A6_HUMAN	collagen, type IV, alpha 6	32	7S domain.				cell adhesion|extracellular matrix organization	collagen type IV	extracellular matrix structural constituent|protein binding			breast(2)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(20)|lung(41)|ovary(7)|prostate(1)|skin(1)|stomach(1)|urinary_tract(2)	92						TCCTGGCCCCCACATGGCTTT	0.433000									Alport syndrome with Diffuse Leiomyomatosis				16	138					0	0	0.592651	0	0
EPB42	2038	broad.mit.edu	37	15	43494107	43494107	+	Silent	SNP	G	G	T			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr15:43494107G>T	ENST00000300215.3	-	12	2395	c.1938C>A	c.(1936-1938)gcC>gcA	p.A646A	EPB42_ENST00000563128.1_5'UTR|EPB42_ENST00000540029.1_Silent_p.A538A|EPB42_ENST00000441366.2_Silent_p.A616A			P16452	EPB42_HUMAN	erythrocyte membrane protein band 4.2	616					erythrocyte maturation|peptide cross-linking|regulation of cell shape	cytoplasm|cytoskeleton|plasma membrane	ATP binding|protein binding|protein-glutamine gamma-glutamyltransferase activity|structural constituent of cytoskeleton			endometrium(3)|large_intestine(6)|lung(6)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	20		all_cancers(109;1.37e-14)|all_epithelial(112;1.26e-12)|Lung NSC(122;2.46e-08)|all_lung(180;2.75e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;8.7e-07)		CCTCCATGGGGGCATCTAGGG	0.552000													12	89					2.23348e-06	2.67847e-06	0.500413	1	0
ZNF560	147741	broad.mit.edu	37	19	9582012	9582012	+	Missense_Mutation	SNP	T	T	A			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr19:9582012T>A	ENST00000301480.4	-	6	494	c.281A>T	c.(280-282)cAg>cTg	p.Q94L		NM_152476.2	NP_689689.2	Q96MR9	ZN560_HUMAN	zinc finger protein 560	94					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(3)|endometrium(3)|kidney(2)|large_intestine(16)|liver(2)|lung(24)|ovary(2)|pancreas(1)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(4)	65						CCAAAACTCCTGCTGCAGTGC	0.308000													6	60					0	0	0.307466	0	0
RD3	343035	broad.mit.edu	37	1	211654671	211654671	+	Silent	SNP	A	A	G			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr1:211654671A>G	ENST00000367002.4	-	2	1250	c.87T>C	c.(85-87)ctT>ctC	p.L29L	RD3_ENST00000484910.1_Intron	NM_001164688.1|NM_183059.2	NP_001158160.1|NP_898882.1	Q7Z3Z2	RD3_HUMAN	retinal degeneration 3	29					response to stimulus|visual perception					central_nervous_system(1)|large_intestine(3)|lung(4)|ovary(1)|prostate(1)	10				OV - Ovarian serous cystadenocarcinoma(81;0.00284)|all cancers(67;0.0279)|Epithelial(68;0.0689)		GCTCCATCATAAGCGTCTCCA	0.632000													23	96					0	0	0.706142	0	0
GCLC	2729	broad.mit.edu	37	6	53370274	53370274	+	Silent	SNP	C	C	T			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr6:53370274C>T	ENST00000229416.6	-	12	1794	c.1311G>A	c.(1309-1311)gaG>gaA	p.E437E	RP1-27K12.4_ENST00000508884.1_RNA	NM_001197115.1|NM_001498.3	NP_001184044.1|NP_001489.1	P48506	GSH1_HUMAN	glutamate-cysteine ligase, catalytic subunit	437					anti-apoptosis|cell redox homeostasis|cysteine metabolic process|glutamate metabolic process|glutathione biosynthetic process|negative regulation of transcription, DNA-dependent|regulation of blood vessel size|response to heat|response to hormone stimulus|response to oxidative stress|xenobiotic metabolic process	cytosol	ADP binding|ATP binding|coenzyme binding|glutamate binding|glutamate-cysteine ligase activity|magnesium ion binding			breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(4)|liver(1)|lung(11)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	22	Lung NSC(77;0.0137)				L-Cysteine(DB00151)|L-Glutamic Acid(DB00142)	AGGCAGAGTTCTCAAAGTCTG	0.443000													3	44					0	0	0.150653	0	0
SLC36A4	120103	broad.mit.edu	37	11	92887297	92887297	+	Missense_Mutation	SNP	C	C	G			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr11:92887297C>G	ENST00000326402.4	-	10	1314	c.1184G>C	c.(1183-1185)aGa>aCa	p.R395T	SLC36A4_ENST00000529184.1_Missense_Mutation_p.R260T	NM_152313.2	NP_689526.2	Q6YBV0	S36A4_HUMAN	solute carrier family 36 (proton/amino acid symporter), member 4	395					L-alanine transport|proline transport|tryptophan transport	integral to membrane	symporter activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(11)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	25		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.0123)				CAAGAAGGATCTTATCCCAAA	0.279000													12	85					0	0	0.411799	0	0
IQSEC2	23096	broad.mit.edu	37	X	53283712	53283712	+	Splice_Site	SNP	C	C	A			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chrX:53283712C>A	ENST00000396435.3	-	4	1601	c.1401_splice	c.e4+1	p.Q467_splice	IQSEC2_ENST00000375365.2_Splice_Site_p.Q262_splice|IQSEC2_ENST00000375368.5_Splice_Site_p.Q457_splice	NM_001111125.2	NP_001104595.1	Q5JU85	IQEC2_HUMAN	IQ motif and Sec7 domain 2	457					regulation of ARF protein signal transduction	cytoplasm	ARF guanyl-nucleotide exchange factor activity			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(4)|lung(10)|ovary(4)|skin(1)	29						GGATCCTGACCTGTTTGGAGA	0.502000													7	64					4.68919e-08	5.77841e-08	0.361761	1	0
DDI1	414301	broad.mit.edu	37	11	103907653	103907653	+	Missense_Mutation	SNP	G	G	A			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr11:103907653G>A	ENST00000302259.3	+	1	346	c.103G>A	c.(103-105)Gaa>Aaa	p.E35K	PDGFD_ENST00000393158.2_Intron|PDGFD_ENST00000302251.5_Intron	NM_001001711.2	NP_001001711.1	Q8WTU0	DDI1_HUMAN	DNA-damage inducible 1 homolog 1 (S. cerevisiae)	35	Ubiquitin-like.				proteolysis		aspartic-type endopeptidase activity			central_nervous_system(1)|endometrium(4)|kidney(4)|large_intestine(12)|liver(2)|lung(21)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	52		Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.00648)|Melanoma(852;0.055)|all_neural(303;0.164)		BRCA - Breast invasive adenocarcinoma(274;0.00128)|Epithelial(105;0.0631)|all cancers(92;0.169)		GGTCCTCTGCGAAGCGGAGTC	0.592000													10	95					0	0	0.335167	0	0
PLA2G15	23659	broad.mit.edu	37	16	68293237	68293237	+	Missense_Mutation	SNP	G	G	A			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr16:68293237G>A	ENST00000219345.5	+	6	999	c.916G>A	c.(916-918)Gat>Aat	p.D306N	PLA2G15_ENST00000444212.2_Missense_Mutation_p.D106N|PLA2G15_ENST00000413021.2_Missense_Mutation_p.D212N|PLA2G15_ENST00000566188.1_3'UTR|RP11-96D1.7_ENST00000563175.1_RNA	NM_012320.3	NP_036452.1	Q8NCC3	PAG15_HUMAN	phospholipase A2, group XV	306					fatty acid catabolic process	extracellular region|lysosome	lysophospholipase activity|phosphatidylcholine-sterol O-acyltransferase activity|phospholipid binding			kidney(2)|large_intestine(2)|lung(2)|ovary(2)|prostate(3)|skin(1)	12						CGGCTTTGAAGATGGCTGGCT	0.577000													4	55					0	0	0.184627	0	0
ZNF3	7551	broad.mit.edu	37	7	99669784	99669784	+	Missense_Mutation	SNP	G	G	A			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr7:99669784G>A	ENST00000303915.6	-	5	1290	c.323C>T	c.(322-324)tCa>tTa	p.S108L	ZNF3_ENST00000424697.1_Missense_Mutation_p.S108L|ZNF3_ENST00000299667.4_Missense_Mutation_p.S108L|ZNF3_ENST00000413658.2_Intron			P17036	ZNF3_HUMAN	zinc finger protein 3	108	KRAB.				cell differentiation|leukocyte activation|multicellular organismal development	nucleus	DNA binding|identical protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding	p.S108*(1)		NS(1)|breast(1)|endometrium(5)|kidney(3)|large_intestine(4)|lung(8)|ovary(1)|skin(2)	25	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)	Ovarian(593;2.06e-05)|Myeloproliferative disorder(862;0.0122)|Breast(660;0.029)	STAD - Stomach adenocarcinoma(171;0.129)			GACCCCATGTGATCTTGTGTC	0.413000													6	61					0	0	0.307466	0	0
LRP12	29967	broad.mit.edu	37	8	105503496	105503496	+	Missense_Mutation	SNP	C	C	G			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr8:105503496C>G	ENST00000276654.5	-	7	2093	c.1985G>C	c.(1984-1986)aGa>aCa	p.R662T	LRP12_ENST00000518375.1_5'UTR|LRP12_ENST00000424843.2_Missense_Mutation_p.R643T	NM_013437.4	NP_038465.1	Q9Y561	LRP12_HUMAN	low density lipoprotein receptor-related protein 12	662					endocytosis|regulation of growth	coated pit|integral to plasma membrane	low-density lipoprotein receptor activity|protein binding			NS(1)|breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(10)|lung(18)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	48			OV - Ovarian serous cystadenocarcinoma(57;1.21e-06)|STAD - Stomach adenocarcinoma(118;0.229)			TGCCATATCTCTTCTCTCATT	0.483000													5	51					0	0	0.248553	0	0
BFAR	51283	broad.mit.edu	37	16	14742340	14742340	+	Missense_Mutation	SNP	A	A	T			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr16:14742340A>T	ENST00000261658.2	+	3	636	c.359A>T	c.(358-360)cAg>cTg	p.Q120L	BFAR_ENST00000426842.2_Intron|BFAR_ENST00000563971.1_Intron	NM_016561.2	NP_057645.1	Q9NZS9	BFAR_HUMAN	bifunctional apoptosis regulator	120					anti-apoptosis|apoptosis	endoplasmic reticulum membrane|integral to plasma membrane|membrane fraction	structural molecule activity|zinc ion binding			endometrium(4)|kidney(1)|large_intestine(2)|lung(1)|ovary(2)|skin(1)	11						GCAGCCTTTCAGAAATATGGG	0.433000													43	180					0	0	0.870114	0	0
CYP3A5	1577	broad.mit.edu	37	7	99250195	99250195	+	Missense_Mutation	SNP	C	C	T			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr7:99250195C>T	ENST00000343703.5	-	12	1590	c.1204G>A	c.(1204-1206)Gag>Aag	p.E402K	CYP3A5_ENST00000339843.2_3'UTR|CYP3A5_ENST00000222982.4_Missense_Mutation_p.E412K					cytochrome P450, family 3, subfamily A, polypeptide 5											NS(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(5)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	16	all_epithelial(64;2.77e-08)|Lung NSC(181;0.00396)|all_lung(186;0.00659)|Esophageal squamous(72;0.0166)					CGGAACTCCTCAGGCTCTGTC	0.473000													5	85					0	0	0.278610	0	0
COL11A1	1301	broad.mit.edu	37	1	103544391	103544391	+	Missense_Mutation	SNP	G	G	C			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr1:103544391G>C	ENST00000358392.2	-	3	628	c.311C>G	c.(310-312)aCa>aGa	p.T104R	COL11A1_ENST00000353414.4_Missense_Mutation_p.T104R|COL11A1_ENST00000370096.3_Missense_Mutation_p.T104R|COL11A1_ENST00000512756.1_Missense_Mutation_p.T104R	NM_080629.2	NP_542196.2	P12107	COBA1_HUMAN	collagen, type XI, alpha 1	104	TSP N-terminal.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			NS(3)|biliary_tract(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(17)|kidney(8)|large_intestine(28)|lung(157)|ovary(6)|pancreas(2)|prostate(6)|skin(9)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(1)	258		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		TGGTTTTACTGTAAATAGTAT	0.333000													9	17					0	0	0.335167	0	0
DOCK2	1794	broad.mit.edu	37	5	169096305	169096305	+	Silent	SNP	A	A	T			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr5:169096305A>T	ENST00000256935.8	+	3	221	c.141A>T	c.(139-141)ggA>ggT	p.G47G		NM_004946.2	NP_004937.1	Q92608	DOCK2_HUMAN	dedicator of cytokinesis 2	47	SH3.				actin cytoskeleton organization|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|endomembrane system|membrane	electron carrier activity|GTP binding|GTPase binding|heme binding|Rac guanyl-nucleotide exchange factor activity|T cell receptor binding			NS(2)|breast(5)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(42)|liver(2)|lung(63)|ovary(5)|pancreas(3)|prostate(7)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)	160	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			GGTATAGGGGATACCTCATAA	0.378000													8	93					0	0	0.307466	0	0
TEC	7006	broad.mit.edu	37	4	48147134	48147134	+	Nonsense_Mutation	SNP	C	C	A			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr4:48147134C>A	ENST00000381501.3	-	14	1589	c.1432G>T	c.(1432-1434)Gag>Tag	p.E478*	TEC_ENST00000511471.2_5'UTR	NM_003215.2	NP_003206.2	P42680	TEC_HUMAN	tec protein tyrosine kinase	478	Protein kinase.				intracellular protein kinase cascade	cytosol	ATP binding|metal ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding			breast(1)|central_nervous_system(1)|kidney(3)|large_intestine(4)|lung(16)|ovary(1)|prostate(2)|skin(2)|stomach(1)	31						TCCAGATACTCCATCCCTTCA	0.488000													42	149					2.69774e-35	3.85568e-35	0.870114	1	0
MSH4	4438	broad.mit.edu	37	1	76363664	76363664	+	Missense_Mutation	SNP	A	A	G	rs111548015		TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr1:76363664A>G	ENST00000263187.3	+	18	2532	c.2428A>G	c.(2428-2430)Atg>Gtg	p.M810V		NM_002440.3	NP_002431.2	O15457	MSH4_HUMAN	mutS homolog 4	810					chiasma assembly|homologous chromosome segregation|mismatch repair|reciprocal meiotic recombination	synaptonemal complex	ATP binding|DNA-dependent ATPase activity|mismatched DNA binding			breast(1)|endometrium(2)|kidney(4)|large_intestine(9)|lung(26)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	47						TGTAGAAAACATGCATTTTGA	0.323000								Mismatch excision repair (MMR)					16	56					0	0	0.520397	0	0
FAM151A	338094	broad.mit.edu	37	1	55081693	55081693	+	Splice_Site	SNP	C	C	T			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr1:55081693C>T	ENST00000302250.2	-	3	575	c.415_splice	c.e3+1	p.G139_splice	ACOT11_ENST00000371316.3_Intron|FAM151A_ENST00000371304.2_Splice_Site_p.G139_splice	NM_176782.2	NP_788954.2	Q8WW52	F151A_HUMAN	family with sequence similarity 151, member A	139						integral to membrane				breast(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(2)|ovary(1)|stomach(1)|upper_aerodigestive_tract(1)	12						AGGCCCTTACCCTTTTGGGAA	0.607000													6	26					0	0	0.307466	0	0
SLCO1A2	6579	broad.mit.edu	37	12	21457474	21457474	+	Missense_Mutation	SNP	A	A	T			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr12:21457474A>T	ENST00000307378.6	-	7	1196	c.476T>A	c.(475-477)gTg>gAg	p.V159E	SLCO1A2_ENST00000390670.3_Missense_Mutation_p.V157E|SLCO1A2_ENST00000452078.1_Missense_Mutation_p.V159E|SLCO1A2_ENST00000537524.1_Missense_Mutation_p.V27E|SLCO1A2_ENST00000458504.1_Missense_Mutation_p.V27E	NM_134431.3	NP_602307.1	P46721	SO1A2_HUMAN	solute carrier organic anion transporter family, member 1A2	159					bile acid metabolic process|sodium-independent organic anion transport	integral to membrane|plasma membrane	bile acid transmembrane transporter activity|organic anion transmembrane transporter activity			breast(2)|endometrium(2)|kidney(4)|large_intestine(8)|lung(23)|ovary(1)|pancreas(1)|skin(6)|upper_aerodigestive_tract(1)	48						TAGGACGTACACCCACATTAA	0.338000													6	142					0	0	0.307466	0	0
CRB1	23418	broad.mit.edu	37	1	197297974	197297974	+	Missense_Mutation	SNP	G	G	C			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr1:197297974G>C	ENST00000367400.3	+	2	628	c.493G>C	c.(493-495)Gat>Cat	p.D165H	CRB1_ENST00000538660.1_Missense_Mutation_p.D165H|CRB1_ENST00000535699.1_Missense_Mutation_p.D96H|CRB1_ENST00000367399.2_Missense_Mutation_p.D165H	NM_201253.2	NP_957705.1	P82279	CRUM1_HUMAN	crumbs homolog 1 (Drosophila)	165	EGF-like 4; calcium-binding (Potential).				cell-cell signaling|establishment or maintenance of cell polarity	apical plasma membrane|extracellular region|integral to membrane	calcium ion binding|protein binding			NS(1)|breast(4)|central_nervous_system(2)|cervix(3)|endometrium(13)|kidney(4)|large_intestine(21)|lung(58)|ovary(7)|prostate(3)|skin(10)|upper_aerodigestive_tract(4)|urinary_tract(2)	132						CGTGTGCCAGGATGGAATTGA	0.512000													8	31					0	0	0.307466	0	0
RAB6B	51560	broad.mit.edu	37	3	133557048	133557048	+	Missense_Mutation	SNP	T	T	C			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr3:133557048T>C	ENST00000285208.4	-	6	806	c.457A>G	c.(457-459)Att>Gtt	p.I153V	RAB6B_ENST00000543906.1_Missense_Mutation_p.I153V|RAB6B_ENST00000486858.1_Missense_Mutation_p.I140V|RAB6B_ENST00000469959.1_Intron	NM_016577.3	NP_057661.3	Q9NRW1	RAB6B_HUMAN	RAB6B, member RAS oncogene family	153					protein transport|retrograde vesicle-mediated transport, Golgi to ER|small GTPase mediated signal transduction	cytoplasmic membrane-bounded vesicle|Golgi membrane	GTP binding|GTPase activity|protein binding			NS(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(5)|pancreas(1)	11						CTGGTCTCAATGAACATGACG	0.612000													31	185					0	0	0.847076	0	0
ZFHX4	79776	broad.mit.edu	37	8	77617004	77617004	+	Missense_Mutation	SNP	C	C	G			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr8:77617004C>G	ENST00000521891.2	+	2	1129	c.681C>G	c.(679-681)ttC>ttG	p.F227L	ZFHX4_ENST00000517683.1_Intron|ZFHX4_ENST00000518282.1_Missense_Mutation_p.F227L|ZFHX4_ENST00000455469.2_Missense_Mutation_p.F227L|ZFHX4_ENST00000050961.6_Missense_Mutation_p.F227L	NM_024721.4	NP_078997.4	Q86UP3	ZFHX4_HUMAN	zinc finger homeobox 4	227						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding	p.F227L(1)		NS(3)|breast(11)|central_nervous_system(1)|endometrium(36)|haematopoietic_and_lymphoid_tissue(2)|kidney(15)|large_intestine(66)|liver(2)|lung(245)|ovary(11)|pancreas(3)|prostate(11)|skin(7)|upper_aerodigestive_tract(13)|urinary_tract(6)	432			BRCA - Breast invasive adenocarcinoma(89;0.0895)			TGCACAGTTTCCGTGTCTATG	0.468000										HNSCC(33;0.089)			7	26					0	0	0.278610	0	0
OR6X1	390260	broad.mit.edu	37	11	123624359	123624359	+	Missense_Mutation	SNP	T	T	A			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr11:123624359T>A	ENST00000327930.2	-	1	894	c.868A>T	c.(868-870)Att>Ttt	p.I290F		NM_001005188.1	NP_001005188.1	Q8NH79	OR6X1_HUMAN	olfactory receptor, family 6, subfamily X, member 1	290					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(3)|endometrium(3)|large_intestine(4)|lung(8)|ovary(2)|prostate(1)|skin(2)	23		Breast(109;0.0109)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0279)		TTGTTTCTAATAGTATAAATA	0.413000													18	90					0	0	0.592651	0	0
CNTNAP2	26047	broad.mit.edu	37	7	146997363	146997363	+	Silent	SNP	C	C	T			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr7:146997363C>T	ENST00000361727.3	+	9	1995	c.1479C>T	c.(1477-1479)ggC>ggT	p.G493G		NM_014141.5	NP_054860.1	Q9UHC6	CNTP2_HUMAN	contactin associated protein-like 2	493	Laminin G-like 2.				behavior|cell adhesion|clustering of voltage-gated potassium channels|limbic system development|neuron recognition|signal transduction|striatum development|superior temporal gyrus development|thalamus development|transmission of nerve impulse	axolemma|cell body fiber|dendrite|juxtaparanode region of axon|voltage-gated potassium channel complex	receptor binding			NS(3)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(21)|lung(105)|ovary(9)|pancreas(2)|prostate(5)|skin(7)|stomach(3)|upper_aerodigestive_tract(6)|urinary_tract(3)	188	Melanoma(164;0.153)	all_cancers(3;3.51e-10)|all_epithelial(3;1.4e-05)|Myeloproliferative disorder(3;0.00452)|Lung NSC(3;0.0067)|all_lung(3;0.00794)	OV - Ovarian serous cystadenocarcinoma(82;0.0319)			TTAAAACTGGCGAGAAGTACT	0.368000										HNSCC(39;0.1)			20	81					0	0	0.693898	0	0
KLK6	5653	broad.mit.edu	37	19	51466708	51466708	+	Missense_Mutation	SNP	C	C	T			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr19:51466708C>T	ENST00000376851.3	-	4	734	c.295G>A	c.(295-297)Gat>Aat	p.D99N	KLK6_ENST00000594641.1_Missense_Mutation_p.D99N|CTB-147C22.8_ENST00000601506.1_RNA|KLK6_ENST00000391808.1_5'UTR|KLK6_ENST00000376853.4_Intron|KLK6_ENST00000310157.2_Missense_Mutation_p.D99N	NM_001012964.1	NP_001012982.1	Q92876	KLK6_HUMAN	kallikrein-related peptidase 6	99	Peptidase S1.				amyloid precursor protein metabolic process|central nervous system development|collagen catabolic process|hormone metabolic process|myelination|positive regulation of G-protein coupled receptor protein signaling pathway|protein autoprocessing|proteolysis|regulation of cell differentiation|tissue regeneration	endoplasmic reticulum|extracellular region|microsome|mitochondrion|nucleolus	protein binding|serine-type endopeptidase activity			endometrium(1)|kidney(2)|large_intestine(2)|lung(4)|skin(4)	13		all_neural(266;0.026)		OV - Ovarian serous cystadenocarcinoma(262;0.00372)|GBM - Glioblastoma multiforme(134;0.00871)		CTGGCGGCATCATAGTCAGGG	0.582000													9	52					0	0	0.361761	0	0
ZNF688	146542	broad.mit.edu	37	16	30581727	30581727	+	Missense_Mutation	SNP	G	G	A			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr16:30581727G>A	ENST00000223459.6	-	3	1445	c.341C>T	c.(340-342)cCg>cTg	p.P114L	ZNF688_ENST00000395219.1_Missense_Mutation_p.P100L	NM_145271.3	NP_660314.1	P0C7X2	ZN688_HUMAN	zinc finger protein 688	114					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.P100Q(1)|p.P114Q(1)		endometrium(3)|large_intestine(2)|lung(2)|ovary(1)	8						GACTTCCTCCGGTTCCTCTTC	0.502000													4	73					0	0	0.248553	0	0
SLITRK1	114798	broad.mit.edu	37	13	84453625	84453625	+	Missense_Mutation	SNP	C	C	A			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr13:84453625C>A	ENST00000377084.2	-	1	2903	c.2018G>T	c.(2017-2019)tGg>tTg	p.W673L		NM_052910.1	NP_443142.1	Q96PX8	SLIK1_HUMAN	SLIT and NTRK-like family, member 1	673						integral to membrane				NS(2)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|liver(1)|lung(36)|ovary(4)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	80	Medulloblastoma(90;0.18)	Breast(118;0.212)		GBM - Glioblastoma multiforme(99;0.07)		CCCATTGTGCCAGTAGGAAGA	0.547000													6	30					3.09899e-07	3.78899e-07	0.307466	1	0
UNC79	57578	broad.mit.edu	37	14	94107578	94107578	+	Missense_Mutation	SNP	C	C	T			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr14:94107578C>T	ENST00000553484.1	+	35	6225	c.6071C>T	c.(6070-6072)aCg>aTg	p.T2024M	UNC79_ENST00000256339.4_Missense_Mutation_p.T1825M|UNC79_ENST00000555664.1_Missense_Mutation_p.T1963M|UNC79_ENST00000393151.2_Missense_Mutation_p.T2002M			Q9P2D8	UNC79_HUMAN	unc-79 homolog (C. elegans)	2002						integral to membrane				breast(3)|cervix(2)|endometrium(10)|kidney(7)|large_intestine(18)|liver(1)|lung(64)|ovary(1)|prostate(5)|skin(3)|urinary_tract(4)	118						GAGCAGCCGACGGTGATGACG	0.468000													5	24					0	0	0.217242	0	0
KIAA1549	57670	broad.mit.edu	37	7	138602171	138602171	+	Missense_Mutation	SNP	G	G	A			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr7:138602171G>A	ENST00000440172.1	-	2	2249	c.2201C>T	c.(2200-2202)aCg>aTg	p.T734M	KIAA1549_ENST00000422774.1_Missense_Mutation_p.T734M|KIAA1549_ENST00000242365.4_Missense_Mutation_p.T684M	NM_001164665.1|NM_020910.2	NP_001158137.1|NP_065961.2	Q9HCM3	K1549_HUMAN	KIAA1549	734	Ser-rich.					integral to membrane			KIAA1549/BRAF(703)	large_intestine(4)|pancreas(1)|upper_aerodigestive_tract(2)	7						CAGTGAAACCGTAGACGCTTC	0.458000			O	BRAF	pilocytic astrocytoma								5	39					0	0	0.217242	0	0
LRIG1	26018	broad.mit.edu	37	3	66436506	66436506	+	Missense_Mutation	SNP	T	T	G			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr3:66436506T>G	ENST00000383703.3	-	14	2363	c.1760A>C	c.(1759-1761)cAc>cCc	p.H587P	LRIG1_ENST00000496559.2_5'UTR|SLC25A26_ENST00000536651.1_Intron|LRIG1_ENST00000273261.3_Missense_Mutation_p.H563P			Q96JA1	LRIG1_HUMAN	leucine-rich repeats and immunoglobulin-like domains 1	563	Ig-like C2-type 1.					integral to membrane				NS(2)|breast(2)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(12)|ovary(3)|prostate(1)|skin(4)|stomach(4)|urinary_tract(1)	42		Lung NSC(201;0.0101)		BRCA - Breast invasive adenocarcinoma(55;0.00047)		CTGACGGAGGTGCAGGATGGT	0.542000													12	61					0	0	0.387290	0	0
ARMCX2	9823	broad.mit.edu	37	X	100911977	100911977	+	Missense_Mutation	SNP	C	C	A			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chrX:100911977C>A	ENST00000328766.5	-	5	1051	c.598G>T	c.(598-600)Gca>Tca	p.A200S	ARMCX2_ENST00000356824.4_Missense_Mutation_p.A200S|ARMCX2_ENST00000330154.2_Missense_Mutation_p.A200S	NM_014782.5	NP_055597.1	Q7L311	ARMX2_HUMAN	armadillo repeat containing, X-linked 2	200	Ala-rich.					integral to membrane	binding			NS(1)|breast(4)|endometrium(3)|kidney(1)|large_intestine(2)|lung(10)|ovary(6)|prostate(1)|skin(1)	29						GTAGGTGCTGCTACCCCAGGA	0.662000													7	35					0.0293803	0.030756	0.248553	1	0
CES5A	221223	broad.mit.edu	37	16	55880391	55880391	+	Missense_Mutation	SNP	T	T	G			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr16:55880391T>G	ENST00000521992.1	-	14	1932	c.1787A>C	c.(1786-1788)cAg>cCg	p.Q596P	CES5A_ENST00000290567.9_Missense_Mutation_p.Q567P|CES5A_ENST00000520435.1_Missense_Mutation_p.Q537P|CES5A_ENST00000518005.1_Missense_Mutation_p.Q461P|CES5A_ENST00000541580.1_5'UTR|CES5A_ENST00000319165.9_Missense_Mutation_p.Q517P	NM_001190158.1	NP_001177087.1	Q6NT32	EST5A_HUMAN	carboxylesterase 5A	567						extracellular region	carboxylesterase activity|methyl indole-3-acetate esterase activity|methyl jasmonate esterase activity|methyl salicylate esterase activity			breast(2)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(8)|lung(13)|ovary(4)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	39						AAAGAAAGGCTGGAGGAGAGA	0.473000													10	88					0	0	0.387290	0	0
HOXA3	3200	broad.mit.edu	37	7	27147556	27147556	+	Missense_Mutation	SNP	G	G	T			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr7:27147556G>T	ENST00000396352.4	-	3	1509	c.1310C>A	c.(1309-1311)gCa>gAa	p.A437E	HOXA-AS2_ENST00000518088.1_RNA|HOXA3_ENST00000317201.2_Missense_Mutation_p.A437E	NM_030661.4	NP_109377.1	O43365	HXA3_HUMAN	homeobox A3	437					angiogenesis	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|cervix(1)|endometrium(3)|large_intestine(4)|lung(18)|skin(1)	29						GAGCTTGGGTGCTTCCTGAAT	0.592000													8	79					1.08611e-07	1.33314e-07	0.387290	1	0
IL15	3600	broad.mit.edu	37	4	142643089	142643089	+	Silent	SNP	A	A	T			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr4:142643089A>T	ENST00000477265.1	+	4	5050	c.42A>T	c.(40-42)gcA>gcT	p.A14A	IL15_ENST00000394159.1_Silent_p.A14A|IL15_ENST00000320650.4_Silent_p.A41A|IL15_ENST00000529613.1_Silent_p.A41A|IL15_ENST00000514653.1_Silent_p.A14A|IL15_ENST00000296545.7_Silent_p.A41A			P40933	IL15_HUMAN	interleukin 15	41					cell-cell signaling|immune response|positive regulation of interleukin-17 production	endosome|extracellular space|Golgi apparatus|integral to plasma membrane|membrane fraction|nucleus	cytokine activity|cytokine receptor binding|signal transducer activity			kidney(1)|large_intestine(1)|lung(2)|stomach(1)	5	all_hematologic(180;0.158)					GTTTCAGTGCAGGGCTTCCTA	0.333000													6	56					0	0	0.307466	0	0
GNA11	2767	broad.mit.edu	37	19	3113345	3113345	+	Silent	SNP	C	C	T			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr19:3113345C>T	ENST00000078429.4	+	3	581	c.339C>T	c.(337-339)atC>atT	p.I113I		NM_002067.2	NP_002058.2	P29992	GNA11_HUMAN	guanine nucleotide binding protein (G protein), alpha 11 (Gq class)	113					activation of phospholipase C activity by dopamine receptor signaling pathway|G-protein signaling, coupled to cAMP nucleotide second messenger|platelet activation|protein ADP-ribosylation|regulation of action potential	cytoplasm|heterotrimeric G-protein complex	G-protein beta/gamma-subunit complex binding|G-protein-coupled receptor binding|GTP binding|GTPase activity|signal transducer activity			endometrium(2)|eye(132)|kidney(1)|large_intestine(2)|lung(1)|meninges(5)|ovary(1)|prostate(1)|skin(16)	161		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.79e-05)|OV - Ovarian serous cystadenocarcinoma(105;2.68e-113)|Epithelial(107;1.22e-111)|all cancers(105;5.78e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00141)|STAD - Stomach adenocarcinoma(1328;0.181)		CGCTCCTGATCCGGGAGGTGG	0.637000			Mis		uveal melanoma								7	65					0	0	0.387290	0	0
NR0B1	190	broad.mit.edu	37	X	30322938	30322938	+	Missense_Mutation	SNP	C	C	A			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chrX:30322938C>A	ENST00000378970.4	-	2	1405	c.1171G>T	c.(1171-1173)Gtg>Ttg	p.V391L		NM_000475.4	NP_000466.2	P51843	NR0B1_HUMAN	nuclear receptor subfamily 0, group B, member 1	391	Ligand-binding (By similarity).				adrenal gland development|hypothalamus development|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of steroid hormone receptor signaling pathway|pituitary gland development|protein localization|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|steroid biosynthetic process	cytoplasm|membrane fraction|nucleoplasm|nucleus|polysomal ribosome	AF-2 domain binding|DNA hairpin binding|ligand-regulated transcription factor activity|protein domain specific binding|protein homodimerization activity|RNA binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|steroid hormone receptor binding|transcription corepressor activity|transcription factor binding			central_nervous_system(2)|endometrium(2)|large_intestine(4)|lung(13)|ovary(1)|skin(2)	24					Dexamethasone(DB01234)|Tretinoin(DB00755)	AGGCCCGGCACGTCTGGAGGG	0.468000													10	35					0.00185496	0.0020372	0.435327	1	0
KRTAP27-1	643812	broad.mit.edu	37	21	31709706	31709706	+	Missense_Mutation	SNP	G	G	T			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr21:31709706G>T	ENST00000382835.2	-	1	306	c.281C>A	c.(280-282)cCc>cAc	p.P94H		NM_001077711.1	NP_001071179.1	Q3LI81	KR271_HUMAN	keratin associated protein 27-1	94						intermediate filament				endometrium(2)|large_intestine(3)|lung(9)|ovary(2)|prostate(1)|skin(1)	18						CCTTTCGCAGGGCCTGGAATT	0.478000													14	98					3.57192e-18	4.94696e-18	0.539581	1	0
CHPF	79586	broad.mit.edu	37	2	220406757	220406757	+	Missense_Mutation	SNP	G	G	A			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr2:220406757G>A	ENST00000243776.6	-	2	717	c.469C>T	c.(469-471)Cgc>Tgc	p.R157C	CHPF_ENST00000373891.2_Missense_Mutation_p.R157C|CHPF_ENST00000535926.1_5'UTR	NM_024536.5	NP_078812.2	Q8IZ52	CHSS2_HUMAN	chondroitin polymerizing factor	157						Golgi cisterna membrane|integral to membrane	glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity|metal ion binding|N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity|protein binding			central_nervous_system(1)|cervix(1)|endometrium(4)|large_intestine(3)|lung(10)|ovary(1)|prostate(1)	21		Renal(207;0.0183)		Epithelial(149;3.02e-08)|all cancers(144;3.41e-06)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00802)		GGGGCCCGGCGGCCCCGTGCG	0.721000											OREG0015229	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	2	2					0	0	0.115264	0	0
GATAD2A	54815	broad.mit.edu	37	19	19606951	19606951	+	Nonsense_Mutation	SNP	G	G	T			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr19:19606951G>T	ENST00000404158.1	+	9	1265	c.847G>T	c.(847-849)Gga>Tga	p.G283*	GATAD2A_ENST00000358713.3_Nonsense_Mutation_p.G283*|GATAD2A_ENST00000360315.3_Nonsense_Mutation_p.G283*|GATAD2A_ENST00000429563.2_Nonsense_Mutation_p.G110*|GATAD2A_ENST00000252577.5_Nonsense_Mutation_p.G283*|GATAD2A_ENST00000537887.1_Intron|GATAD2A_ENST00000494516.1_Intron			Q86YP4	P66A_HUMAN	GATA zinc finger domain containing 2A	283					DNA methylation|negative regulation of transcription, DNA-dependent	nuclear speck|NuRD complex	protein binding, bridging|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(2)|kidney(1)|large_intestine(2)|lung(6)|ovary(1)|urinary_tract(1)	13						GCAGATTCAGGGACAGAGGAT	0.632000													6	66					0.00116845	0.00128776	0.217242	1	0
ZNF18	7566	broad.mit.edu	37	17	11895931	11895931	+	Silent	SNP	T	T	C			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr17:11895931T>C	ENST00000322748.3	-	4	820	c.216A>G	c.(214-216)ccA>ccG	p.P72P	ZNF18_ENST00000454073.3_Silent_p.P72P|ZNF18_ENST00000580613.1_Silent_p.P21P|ZNF18_ENST00000580306.1_Silent_p.P72P	NM_144680.2	NP_653281.2	P17022	ZNF18_HUMAN	zinc finger protein 18	72	SCAN box.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(4)	14				Colorectal(4;3.33e-05)|COAD - Colon adenocarcinoma(4;0.000494)|READ - Rectum adenocarcinoma(10;0.233)		TGTGAACCTCTGGCTGTAGCC	0.542000													8	49					0	0	0.307466	0	0
CNTNAP2	26047	broad.mit.edu	37	7	147675022	147675022	+	Missense_Mutation	SNP	C	C	T			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr7:147675022C>T	ENST00000361727.3	+	15	2840	c.2324C>T	c.(2323-2325)aCt>aTt	p.T775I		NM_014141.5	NP_054860.1	Q9UHC6	CNTP2_HUMAN	contactin associated protein-like 2	775	Fibrinogen C-terminal.				behavior|cell adhesion|clustering of voltage-gated potassium channels|limbic system development|neuron recognition|signal transduction|striatum development|superior temporal gyrus development|thalamus development|transmission of nerve impulse	axolemma|cell body fiber|dendrite|juxtaparanode region of axon|voltage-gated potassium channel complex	receptor binding			NS(3)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(21)|lung(105)|ovary(9)|pancreas(2)|prostate(5)|skin(7)|stomach(3)|upper_aerodigestive_tract(6)|urinary_tract(3)	188	Melanoma(164;0.153)	all_cancers(3;3.51e-10)|all_epithelial(3;1.4e-05)|Myeloproliferative disorder(3;0.00452)|Lung NSC(3;0.0067)|all_lung(3;0.00794)	OV - Ovarian serous cystadenocarcinoma(82;0.0319)			GTTGGAGATACTGACCGTCAA	0.483000										HNSCC(39;0.1)			10	70					0	0	0.411799	0	0
AAAS	8086	broad.mit.edu	37	12	53709521	53709521	+	Missense_Mutation	SNP	T	T	C			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr12:53709521T>C	ENST00000550286.1	-	3	370	c.17A>G	c.(16-18)cAg>cGg	p.Q6R	AAAS_ENST00000549983.1_5'UTR|AAAS_ENST00000394384.3_Silent_p.S99S|AAAS_ENST00000209873.4_Silent_p.S99S			Q9NRG9	AAAS_HUMAN	achalasia, adrenocortical insufficiency, alacrimia	0					carbohydrate metabolic process|glucose transport|nucleocytoplasmic transport|regulation of glucose transport|regulation of nucleocytoplasmic transport|transmembrane transport|viral reproduction	nuclear pore				breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(5)|ovary(1)|prostate(1)|skin(2)	20						CCTCTTCTTCTGAGTTTGCAA	0.488000													8	24					0	0	0.307466	0	0
NOX3	50508	broad.mit.edu	37	6	155776209	155776209	+	Missense_Mutation	SNP	C	C	T			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr6:155776209C>T	ENST00000159060.2	-	2	205	c.103G>A	c.(103-105)Gaa>Aaa	p.E35K		NM_015718.2	NP_056533.1	Q9HBY0	NOX3_HUMAN	NADPH oxidase 3	35							electron carrier activity|flavin adenine dinucleotide binding|iron ion binding			cervix(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(16)|ovary(1)|pancreas(1)|prostate(4)|upper_aerodigestive_tract(1)	45		Breast(66;0.0183)		OV - Ovarian serous cystadenocarcinoma(155;2.18e-12)|BRCA - Breast invasive adenocarcinoma(81;0.00815)		TCCTCCTCTTCATACCAGTAG	0.328000													5	45					0	0	0.307466	0	0
SEZ6L	23544	broad.mit.edu	37	22	26706657	26706657	+	Missense_Mutation	SNP	G	G	C			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr22:26706657G>C	ENST00000529632.2	+	7	1732	c.1536G>C	c.(1534-1536)caG>caC	p.Q512H	SEZ6L_ENST00000248933.6_Missense_Mutation_p.Q512H|SEZ6L_ENST00000360929.3_Missense_Mutation_p.Q512H|SEZ6L_ENST00000402979.1_Missense_Mutation_p.Q285H|SEZ6L_ENST00000343706.4_Missense_Mutation_p.Q512H|SEZ6L_ENST00000403121.1_Missense_Mutation_p.Q285H|SEZ6L_ENST00000404234.3_Missense_Mutation_p.Q512H	NM_001184774.1|NM_001184775.1|NM_001184777.1	NP_001171703.1|NP_001171704.1|NP_001171706.1	Q9BYH1	SE6L1_HUMAN	seizure related 6 homolog (mouse)-like	512	CUB 2.					endoplasmic reticulum membrane|integral to membrane				breast(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|lung(35)|ovary(4)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	80						ACAGCGGGCAGACCAACAAGT	0.567000													28	97					0	0	0.769981	0	0
SCARB1	949	broad.mit.edu	37	12	125270965	125270965	+	Missense_Mutation	SNP	C	C	T			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr12:125270965C>T	ENST00000339570.5	-	11	1535	c.1339G>A	c.(1339-1341)Gtc>Atc	p.V447I	SCARB1_ENST00000415380.2_Missense_Mutation_p.V447I|SCARB1_ENST00000544327.1_Missense_Mutation_p.V393I|SCARB1_ENST00000376788.1_Missense_Mutation_p.V347I|SCARB1_ENST00000546215.1_Intron|SCARB1_ENST00000261693.6_Missense_Mutation_p.V447I|SCARB1_ENST00000535005.1_5'UTR|SCARB1_ENST00000540495.1_Missense_Mutation_p.V410I|SCARB1_ENST00000541205.1_Missense_Mutation_p.V406I	NM_001082959.1	NP_001076428.1	Q8WTV0	SCRB1_HUMAN	scavenger receptor class B, member 1	447					adhesion to symbiont|cell adhesion|cholesterol efflux|cholesterol homeostasis|cholesterol import|detection of lipopolysaccharide|high-density lipoprotein particle clearance|high-density lipoprotein particle remodeling|lipopolysaccharide transport|lipoprotein metabolic process|positive regulation of cholesterol storage|positive regulation of endothelial cell migration|positive regulation of nitric-oxide synthase activity|recognition of apoptotic cell|reverse cholesterol transport|triglyceride homeostasis|wound healing	caveola	1-phosphatidylinositol binding|apolipoprotein A-I binding|high-density lipoprotein particle receptor activity|lipopolysaccharide receptor activity|low-density lipoprotein particle binding|phosphatidylserine binding|transporter activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(7)|prostate(1)	17	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000116)|Epithelial(86;0.000415)|all cancers(50;0.00395)	Phosphatidylserine(DB00144)	GCCAGGAGGACGTACTGGGCA	0.612000													9	132					0	0	0.335167	0	0
ANKRD11	29123	broad.mit.edu	37	16	89354971	89354971	+	Missense_Mutation	SNP	G	G	C			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr16:89354971G>C	ENST00000301030.4	-	7	1169	c.709C>G	c.(709-711)Cct>Gct	p.P237A	ANKRD11_ENST00000378330.2_Missense_Mutation_p.P237A	NM_001256183.1|NM_013275.5	NP_001243112.1|NP_037407.4	Q6UB99	ANR11_HUMAN	ankyrin repeat domain 11	237						nucleus				breast(4)|central_nervous_system(3)|endometrium(17)|kidney(2)|large_intestine(18)|lung(20)|ovary(6)|pancreas(1)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	83		all_hematologic(23;0.00824)|Colorectal(91;0.0475)		Epithelial(1;5.33e-11)|all cancers(4;2.6e-09)|OV - Ovarian serous cystadenocarcinoma(4;2.29e-07)|BRCA - Breast invasive adenocarcinoma(80;0.0142)		TCGTGCAAAGGCGTGTCGTCA	0.617000													8	38					0	0	0.361761	0	0
SRL	6345	broad.mit.edu	37	16	4242645	4242645	+	Missense_Mutation	SNP	C	C	G			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr16:4242645C>G	ENST00000399609.3	-	6	943	c.931G>C	c.(931-933)Gag>Cag	p.E311Q	SRL_ENST00000537996.1_Missense_Mutation_p.E269Q	NM_001098814.1	NP_001092284.1	Q86TD4	SRCA_HUMAN	sarcalumenin	770	Acidic domain, probably binds calcium (By similarity).					sarcoplasmic reticulum lumen	GTP binding|GTPase activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(8)|ovary(3)|skin(3)	21						AGGGAGATCTCTTCTTGGAGG	0.547000													11	113					0	0	0.361761	0	0
MYPN	84665	broad.mit.edu	37	10	69926170	69926170	+	Missense_Mutation	SNP	C	C	T			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr10:69926170C>T	ENST00000358913.5	+	10	2208	c.1720C>T	c.(1720-1722)Ccc>Tcc	p.P574S	MYPN_ENST00000354393.2_Missense_Mutation_p.P299S|MYPN_ENST00000540630.1_Missense_Mutation_p.P574S	NM_001256267.1|NM_032578.3	NP_001243196.1|NP_115967.2	Q86TC9	MYPN_HUMAN	myopalladin	574						nucleus|sarcomere	actin binding			breast(2)|central_nervous_system(1)|endometrium(13)|kidney(6)|large_intestine(13)|liver(1)|lung(43)|ovary(3)|prostate(1)|skin(6)|upper_aerodigestive_tract(5)	94						GGAACAACCCCCCAAACCCAA	0.577000													6	34					0	0	0.248553	0	0
DSE	29940	broad.mit.edu	37	6	116757051	116757051	+	Missense_Mutation	SNP	G	G	T			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr6:116757051G>T	ENST00000331677.3	+	7	1864	c.1420G>T	c.(1420-1422)Ggg>Tgg	p.G474W	DSE_ENST00000359564.2_Missense_Mutation_p.G474W|DSE_ENST00000537543.1_Missense_Mutation_p.G493W|DSE_ENST00000452085.3_Missense_Mutation_p.G474W			Q9UL01	DSE_HUMAN	dermatan sulfate epimerase	474					dermatan sulfate biosynthetic process	endoplasmic reticulum|Golgi apparatus|integral to membrane	chondroitin-glucuronate 5-epimerase activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|liver(2)|lung(12)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	35		all_cancers(87;0.00019)|all_epithelial(87;0.000416)|Ovarian(999;0.133)|Colorectal(196;0.234)		Epithelial(106;0.00915)|OV - Ovarian serous cystadenocarcinoma(136;0.0149)|GBM - Glioblastoma multiforme(226;0.0189)|all cancers(137;0.0262)		GGCTCTGTACGGGCCAAAGTA	0.453000													21	38					3.01185e-09	3.78598e-09	0.667858	1	0
INTS8	55656	broad.mit.edu	37	8	95850846	95850846	+	Splice_Site	SNP	G	G	T			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr8:95850846G>T	ENST00000523731.1	+	8	1150	c.1017_splice	c.e8+1	p.Q339_splice	INTS8_ENST00000447247.1_Splice_Site_p.Q339_splice	NM_017864.2	NP_060334.2	Q75QN2	INT8_HUMAN	integrator complex subunit 8	339					snRNA processing	integrator complex	protein binding			breast(3)|endometrium(3)|kidney(1)|large_intestine(9)|liver(1)|lung(9)|prostate(1)|upper_aerodigestive_tract(1)	28	Breast(36;1.05e-06)					GCAACTATCAGGTAAGGTGTA	0.423000													34	51					6.53348e-20	9.17031e-20	0.788014	1	0
PCDHA6	56142	broad.mit.edu	37	5	140208228	140208228	+	Silent	SNP	A	A	T			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr5:140208228A>T	ENST00000529310.1	+	1	666	c.552A>T	c.(550-552)atA>atT	p.I184I	PCDHA1_ENST00000504120.2_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA6_ENST00000527624.1_Silent_p.I184I|PCDHA2_ENST00000526136.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA4_ENST00000512229.2_Intron	NM_018909.2|NM_031848.1|NM_031849.1	NP_061732.1|NP_114036.1|NP_114037.1												p.I184M(2)		NS(1)|breast(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(11)|lung(42)|prostate(8)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	89			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ATGTGAAAATAAACAGTGATG	0.438000													5	64					0	0	0.184627	0	0
PSAT1	29968	broad.mit.edu	37	9	80943085	80943085	+	Silent	SNP	T	T	C			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr9:80943085T>C	ENST00000376588.3	+	8	1056	c.988T>C	c.(988-990)Ttg>Ctg	p.L330L	PSAT1_ENST00000347159.2_Intron	NM_058179.2	NP_478059.1	Q9Y617	SERC_HUMAN	phosphoserine aminotransferase 1	330					L-serine biosynthetic process|pyridoxine biosynthetic process		O-phospho-L-serine:2-oxoglutarate aminotransferase activity|pyridoxal phosphate binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(9)|ovary(1)|urinary_tract(1)	20					L-Glutamic Acid(DB00142)|Pyridoxal Phosphate(DB00114)|Pyridoxine(DB00165)	ACTCAATATGTTGTCCTTGAA	0.363000													3	24					0	0	0.150653	0	0
TFEB	7942	broad.mit.edu	37	6	41658524	41658524	+	Silent	SNP	C	C	T			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr6:41658524C>T	ENST00000394283.1	-	3	1571	c.345G>A	c.(343-345)ccG>ccA	p.P115P	TFEB_ENST00000358871.2_Silent_p.P129P|TFEB_ENST00000373033.1_Silent_p.P115P|TFEB_ENST00000420312.1_Intron|TFEB_ENST00000230323.4_Silent_p.P115P|TFEB_ENST00000403298.4_Silent_p.P115P			P19484	TFEB_HUMAN	transcription factor EB	115				GSPKPPPAASPGVRAGHVLSSSAGNSAPN -> ALRNPHQP PPQGCELDTCCPPPLATVLPI (in Ref. 1; AAA36730).	embryonic placenta development|humoral immune response|positive regulation of transcription from RNA polymerase II promoter	cytoplasm	sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(3)|ovary(1)|prostate(1)	11	Ovarian(28;0.0355)|Colorectal(47;0.121)		Epithelial(12;7.61e-05)|STAD - Stomach adenocarcinoma(11;0.000204)|Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00507)			GTGGGGGTTTCGGAGAGCCCT	0.632000			T	ALPHA	renal (childhood epithelioid)								5	58					0	0	0.248553	0	0
MAGEA10	4109	broad.mit.edu	37	X	151303999	151303999	+	Silent	SNP	G	G	A			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chrX:151303999G>A	ENST00000370323.4	-	4	410	c.94C>T	c.(94-96)Ctg>Ttg	p.L32L	MAGEA10_ENST00000244096.3_Silent_p.L32L|RP11-1007I13.4_ENST00000509345.2_RNA	NM_001251828.1|NM_021048.4	NP_001238757.1|NP_066386.2	P43363	MAGAA_HUMAN	melanoma antigen family A, 10	32										endometrium(2)|kidney(2)|large_intestine(4)|lung(11)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	23	Acute lymphoblastic leukemia(192;6.56e-05)					TCCACAGCCAGGGGAGCCTGT	0.562000													4	85					0	0	0.150653	0	0
DNAH10	196385	broad.mit.edu	37	12	124364265	124364265	+	Missense_Mutation	SNP	G	G	T			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr12:124364265G>T	ENST00000409039.3	+	49	8222	c.8197G>T	c.(8197-8199)Gac>Tac	p.D2733Y		NM_207437.3	NP_997320.2	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	2733					microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(14)|ovary(4)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	52	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		ATTGTTTGGAGACTTCCAGAT	0.517000													54	138					1.12612e-26	1.59491e-26	0.870114	1	0
KCND2	3751	broad.mit.edu	37	7	119915061	119915061	+	Silent	SNP	C	C	A			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr7:119915061C>A	ENST00000331113.4	+	1	1340	c.375C>A	c.(373-375)atC>atA	p.I125I		NM_012281.2	NP_036413.1	Q9NZV8	KCND2_HUMAN	potassium voltage-gated channel, Shal-related subfamily, member 2	125					regulation of action potential|synaptic transmission	cell surface|dendritic spine	metal ion binding	p.P126T(1)|p.I125I(1)		NS(2)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(8)|kidney(2)|large_intestine(11)|lung(35)|ovary(3)|pancreas(1)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)	75	all_neural(327;0.117)					TTGGCCTCATCCCGGAAATCA	0.582000													14	118					4.7546e-09	5.95276e-09	0.500413	1	0
BEX2	84707	broad.mit.edu	37	X	102564744	102564744	+	Missense_Mutation	SNP	C	C	A			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chrX:102564744C>A	ENST00000536889.1	-	3	614	c.257G>T	c.(256-258)aGg>aTg	p.R86M	BEX2_ENST00000372674.1_Missense_Mutation_p.R54M|BEX2_ENST00000372677.3_Missense_Mutation_p.R54M	NM_001168399.1|NM_001168400.1	NP_001161871.1|NP_001161872.1	Q9BXY8	BEX2_HUMAN	brain expressed X-linked 2	54					apoptosis|cell cycle|regulation of apoptosis|regulation of cell cycle	cytoplasm|nucleus				endometrium(1)|lung(1)|ovary(1)	3						GCGGAACCGCCTACGGTTTCC	0.478000													8	129					0.00621372	0.00670653	0.335167	1	0
FAT2	2196	broad.mit.edu	37	5	150934210	150934210	+	Missense_Mutation	SNP	G	G	A			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr5:150934210G>A	ENST00000261800.5	-	4	3670	c.3658C>T	c.(3658-3660)Ccc>Tcc	p.P1220S		NM_001447.2	NP_001438.1	Q9NYQ8	FAT2_HUMAN	FAT atypical cadherin 2	1220	Cadherin 10.				epithelial cell migration|homophilic cell adhesion	cell-cell adherens junction|integral to membrane|nucleus	calcium ion binding			NS(6)|breast(3)|central_nervous_system(3)|cervix(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(61)|liver(1)|lung(60)|ovary(6)|prostate(5)|skin(5)|stomach(2)|upper_aerodigestive_tract(11)|urinary_tract(1)	196		Medulloblastoma(196;0.0912)|all_hematologic(541;0.104)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			TTCAGTGAGGGTTCCCCATTG	0.488000													9	88					0	0	0.307466	0	0
ZNF780A	284323	broad.mit.edu	37	19	40580555	40580555	+	Missense_Mutation	SNP	C	C	T			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr19:40580555C>T	ENST00000450241.2	-	6	2003	c.1692G>A	c.(1690-1692)atG>atA	p.M564I	ZNF780A_ENST00000595687.2_Missense_Mutation_p.M598I|AC005614.5_ENST00000595508.1_RNA|ZNF780A_ENST00000594395.1_Missense_Mutation_p.M599I|ZNF780A_ENST00000455521.1_Missense_Mutation_p.M599I|ZNF780A_ENST00000414720.2_Intron|ZNF780A_ENST00000340963.5_Missense_Mutation_p.M598I			O75290	Z780A_HUMAN	zinc finger protein 780A	598					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(1)|kidney(1)|large_intestine(7)|lung(16)|upper_aerodigestive_tract(3)|urinary_tract(1)	31	all_cancers(60;9.55e-06)|all_lung(34;1.17e-07)|Lung NSC(34;1.41e-07)|Ovarian(47;0.0925)					GAATAAGTTGCATATGAAGTC	0.408000													12	75					0	0	0.479597	0	0
FCHO2	115548	broad.mit.edu	37	5	72313065	72313065	+	Missense_Mutation	SNP	G	G	C			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr5:72313065G>C	ENST00000430046.2	+	8	842	c.726G>C	c.(724-726)atG>atC	p.M242I	FCHO2_ENST00000287761.6_Missense_Mutation_p.M242I|FCHO2_ENST00000341845.6_Missense_Mutation_p.M242I|FCHO2_ENST00000512348.1_Missense_Mutation_p.M209I	NM_001146032.1|NM_138782.2	NP_001139504.1|NP_620137.2	Q0JRZ9	FCHO2_HUMAN	FCH domain only 2	242										cervix(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(4)|ovary(1)|prostate(1)	17		Lung NSC(167;0.0465)|Ovarian(174;0.0908)|Prostate(461;0.165)		OV - Ovarian serous cystadenocarcinoma(47;4.6e-53)		TAAATAACATGGCTAATACTA	0.303000													3	3					0	0	0.115264	0	0
NOX3	50508	broad.mit.edu	37	6	155776017	155776017	+	Silent	SNP	C	C	T			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr6:155776017C>T	ENST00000159060.2	-	3	285	c.183G>A	c.(181-183)ctG>ctA	p.L61L		NM_015718.2	NP_056533.1	Q9HBY0	NOX3_HUMAN	NADPH oxidase 3	61	Ferric oxidoreductase.						electron carrier activity|flavin adenine dinucleotide binding|iron ion binding			cervix(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(16)|ovary(1)|pancreas(1)|prostate(4)|upper_aerodigestive_tract(1)	45		Breast(66;0.0183)		OV - Ovarian serous cystadenocarcinoma(155;2.18e-12)|BRCA - Breast invasive adenocarcinoma(81;0.00815)		AGTTAAAATTCAGGCACAGTG	0.368000													5	39					0	0	0.184627	0	0
ZFC3H1	196441	broad.mit.edu	37	12	72026673	72026673	+	Missense_Mutation	SNP	C	C	A			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr12:72026673C>A	ENST00000378743.3	-	14	3168	c.2810G>T	c.(2809-2811)cGc>cTc	p.R937L		NM_144982.4	NP_659419.3	O60293	ZC3H1_HUMAN	zinc finger, C3H1-type containing	937					RNA processing	intracellular	metal ion binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(4)|large_intestine(12)|lung(31)|ovary(3)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	69						CACCCCAAAGCGATCTTGTTC	0.348000													3	94					0.184627	0.187624	0.184627	1	0
NSD1	64324	broad.mit.edu	37	5	176722250	176722250	+	Silent	SNP	G	G	T			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr5:176722250G>T	ENST00000439151.2	+	23	7926	c.7881G>T	c.(7879-7881)ctG>ctT	p.L2627L	NSD1_ENST00000361032.4_Silent_p.L2524L|NSD1_ENST00000354179.4_Silent_p.L2358L|NSD1_ENST00000347982.4_Silent_p.L2358L	NM_022455.4	NP_071900.2	Q96L73	NSD1_HUMAN	nuclear receptor binding SET domain protein 1	2627					negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	androgen receptor binding|chromatin binding|estrogen receptor binding|histone methyltransferase activity (H3-K36 specific)|histone methyltransferase activity (H4-K20 specific)|ligand-dependent nuclear receptor binding|retinoid X receptor binding|thyroid hormone receptor binding|transcription corepressor activity|zinc ion binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(13)|large_intestine(18)|lung(24)|ovary(2)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(7)|urinary_tract(3)	96	all_cancers(89;1.57e-05)|Renal(175;0.000269)|Lung NSC(126;0.00111)|all_lung(126;0.002)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)|Epithelial(233;0.198)	Kidney(146;0.235)		CCTGGGCCCTGGGAAAAGCCT	0.577000			T	NUP98	AML		Sotos Syndrome		Weaver syndrome;Sotos syndrome;Beckwith-Wiedemann syndrome	HNSCC(47;0.14)			3	46					0.115264	0.118287	0.115264	1	0
ERAL1	26284	broad.mit.edu	37	17	27182139	27182139	+	Silent	SNP	G	G	A			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr17:27182139G>A	ENST00000254928.5	+	1	184	c.87G>A	c.(85-87)cgG>cgA	p.R29R	ERAL1_ENST00000578001.1_3'UTR	NM_005702.2	NP_005693.1	O75616	ERAL1_HUMAN	Era-like 12S mitochondrial rRNA chaperone 1	29					ribosomal small subunit assembly	mitochondrial inner membrane|mitochondrial matrix	GTP binding|ribosomal small subunit binding|rRNA binding			endometrium(1)|kidney(1)|large_intestine(2)|lung(5)|skin(2)	11	all_cancers(5;2.12e-15)|all_epithelial(6;3.44e-19)|Lung NSC(42;0.01)		Epithelial(11;1.12e-05)|all cancers(11;5.32e-05)|BRCA - Breast invasive adenocarcinoma(11;0.000272)|OV - Ovarian serous cystadenocarcinoma(11;0.105)			CGAGGGAGCGGGTGATCCCTT	0.637000													10	60					0	0	0.361761	0	0
CT47B1	643311	broad.mit.edu	37	X	120008756	120008756	+	Missense_Mutation	SNP	G	G	T			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chrX:120008756G>T	ENST00000371311.3	-	1	1023	c.769C>A	c.(769-771)Ccc>Acc	p.P257T		NM_001145718.1	NP_001139190.1	P0C2W7	CT47B_HUMAN	cancer/testis antigen family 47, member B1	257										breast(1)|central_nervous_system(1)|endometrium(7)|kidney(2)|lung(9)|ovary(1)|skin(1)	22						TTACCCTCGGGGGCCACGGCC	0.682000													18	112					9.95505e-16	1.34307e-15	0.624587	1	0
CPM	1368	broad.mit.edu	37	12	69326608	69326608	+	Missense_Mutation	SNP	G	G	A			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr12:69326608G>A	ENST00000551568.1	-	2	70	c.10C>T	c.(10-12)Ccg>Tcg	p.P4S	CPM_ENST00000338356.3_Missense_Mutation_p.P4S|CPM_ENST00000546373.1_Missense_Mutation_p.P4S	NM_001005502.2|NM_198320.3	NP_001005502.1|NP_938079.1	P14384	CBPM_HUMAN	carboxypeptidase M	4					anatomical structure morphogenesis|proteolysis	anchored to membrane|cytoplasm|nucleus|plasma membrane	metallocarboxypeptidase activity|zinc ion binding			large_intestine(1)|lung(6)|prostate(2)	9	all_epithelial(5;1.09e-35)|Lung NSC(4;1.47e-33)|all_lung(4;1.02e-31)|Breast(13;1.59e-06)		all cancers(2;2.69e-50)|GBM - Glioblastoma multiforme(2;7.34e-41)|BRCA - Breast invasive adenocarcinoma(5;5.38e-10)|Lung(24;4.61e-05)|LUAD - Lung adenocarcinoma(15;0.000376)|STAD - Stomach adenocarcinoma(21;0.00372)|Kidney(9;0.143)			CAGAGGCACGGGAAGTCCATG	0.532000													17	45					0	0	0.592651	0	0
MAT1A	4143	broad.mit.edu	37	10	82049159	82049159	+	Silent	SNP	G	G	T			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr10:82049159G>T	ENST00000372213.3	-	1	281	c.21C>A	c.(19-21)ggC>ggA	p.G7G		NM_000429.2	NP_000420.1	Q00266	METK1_HUMAN	methionine adenosyltransferase I, alpha	7					methylation|S-adenosylmethionine biosynthetic process|xenobiotic metabolic process	cytosol	ATP binding|metal ion binding|methionine adenosyltransferase activity			endometrium(4)|large_intestine(7)|lung(10)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	26			Colorectal(32;0.229)		L-Methionine(DB00134)|S-Adenosylmethionine(DB00118)	GGTCACACAAGCCATCCACCG	0.473000													18	75					3.83957e-06	4.58697e-06	0.639603	1	0
C8orf31	286122	broad.mit.edu	37	8	144124454	144124454	+	Silent	SNP	A	A	G			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr8:144124454A>G	ENST00000395172.1	+	2	388	c.36A>G	c.(34-36)tcA>tcG	p.S12S	C8orf31_ENST00000517653.1_Intron	NM_173687.2	NP_775958.1	Q8N9H6	CH031_HUMAN	chromosome 8 open reading frame 31	12										breast(1)|kidney(1)|large_intestine(3)|lung(4)|ovary(1)	10	all_cancers(97;1.89e-10)|all_epithelial(106;8.73e-09)|Lung NSC(106;0.000161)|all_lung(105;0.000447)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)					CCTGCAATTCAGTGAGGCAGC	0.602000													20	80					0	0	0.654019	0	0
OR2T4	127074	broad.mit.edu	37	1	248525679	248525679	+	Missense_Mutation	SNP	G	G	T			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr1:248525679G>T	ENST00000366475.1	+	1	797	c.797G>T	c.(796-798)cGg>cTg	p.R266L		NM_001004696.1	NP_001004696.1	Q8NH00	OR2T4_HUMAN	olfactory receptor, family 2, subfamily T, member 4	266					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(3)|liver(2)|lung(47)	56	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			GCAGAGGGCCGGAAAAAGGCC	0.547000													35	98					9.8876e-21	1.39406e-20	0.804634	1	0
SERPINA9	327657	broad.mit.edu	37	14	94929540	94929540	+	Missense_Mutation	SNP	G	G	A			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr14:94929540G>A	ENST00000337425.5	-	5	1272	c.1198C>T	c.(1198-1200)Ccc>Tcc	p.P400S	SERPINA9_ENST00000424550.2_Missense_Mutation_p.P251S|SERPINA9_ENST00000298845.7_Missense_Mutation_p.P300S|RP11-349I1.2_ENST00000536735.1_RNA|SERPINA9_ENST00000448305.2_Missense_Mutation_p.P302S|SERPINA9_ENST00000380365.3_Missense_Mutation_p.P382S	NM_175739.3	NP_783866.2	Q86WD7	SPA9_HUMAN	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 9	382					regulation of proteolysis	cytoplasm|extracellular region|membrane	serine-type endopeptidase inhibitor activity			NS(1)|central_nervous_system(1)|kidney(1)|large_intestine(1)|lung(17)	21		all_cancers(154;0.0691)|all_epithelial(191;0.233)		Epithelial(152;0.144)|COAD - Colon adenocarcinoma(157;0.224)|all cancers(159;0.24)		AAGTAAGAGGGGCCATCCTTC	0.498000													11	86					0	0	0.435327	0	0
ALX3	257	broad.mit.edu	37	1	110607216	110607216	+	Missense_Mutation	SNP	C	C	T	rs112456669		TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr1:110607216C>T	ENST00000369792.4	-	2	674	c.587G>A	c.(586-588)cGg>cAg	p.R196Q		NM_006492.2	NP_006483.2	O95076	ALX3_HUMAN	ALX homeobox 3	196			R -> W (in FND1).			nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			large_intestine(1)|lung(3)|skin(1)|upper_aerodigestive_tract(1)	6		all_cancers(81;2.35e-05)|all_epithelial(167;7.69e-06)|all_lung(203;0.000116)|Lung NSC(277;0.000233)		Lung(183;0.015)|all cancers(265;0.0706)|Epithelial(280;0.0758)|Colorectal(144;0.113)|LUSC - Lung squamous cell carcinoma(189;0.135)		CACCTGTACCCGGGCCTCAGT	0.602000													9	35					0	0	0.411799	0	0
YARS2	51067	broad.mit.edu	37	12	32908396	32908396	+	Missense_Mutation	SNP	C	C	T			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr12:32908396C>T	ENST00000324868.8	-	1	440	c.413G>A	c.(412-414)cGa>cAa	p.R138Q		NM_001040436.2	NP_001035526.1	Q9Y2Z4	SYYM_HUMAN	tyrosyl-tRNA synthetase 2, mitochondrial	138					tyrosyl-tRNA aminoacylation	mitochondrial matrix	ATP binding|protein binding|RNA binding|tyrosine-tRNA ligase activity			endometrium(1)|large_intestine(4)|lung(9)|prostate(1)|upper_aerodigestive_tract(1)	16	Lung NSC(5;2.43e-07)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.239)				L-Tyrosine(DB00135)	CGCGTTGGCTCGCACGCGCTC	0.687000											OREG0021729	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	3	9					0	0	0.184627	0	0
ANKRD30A	91074	broad.mit.edu	37	10	37488690	37488690	+	Missense_Mutation	SNP	G	G	T			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr10:37488690G>T	ENST00000374660.1	+	36	3040	c.2941G>T	c.(2941-2943)Gtt>Ttt	p.V981F	ANKRD30A_ENST00000361713.1_Missense_Mutation_p.V862F|ANKRD30A_ENST00000602533.1_Missense_Mutation_p.V862F			Q9BXX3	AN30A_HUMAN	ankyrin repeat domain 30A	1018						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(8)|endometrium(14)|kidney(21)|large_intestine(13)|lung(70)|ovary(8)|pancreas(1)|prostate(3)|skin(15)|stomach(1)|urinary_tract(3)	158						ACAAAAGAAGGTTGAAGAAAA	0.274000													3	26					0.014758	0.0156585	0.184627	1	0
DOCK2	1794	broad.mit.edu	37	5	169461502	169461502	+	Silent	SNP	G	G	T			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr5:169461502G>T	ENST00000256935.8	+	35	3647	c.3567G>T	c.(3565-3567)cgG>cgT	p.R1189R	DOCK2_ENST00000540750.1_Silent_p.R250R|DOCK2_ENST00000523351.1_3'UTR|DOCK2_ENST00000520908.1_Silent_p.R681R	NM_004946.2	NP_004937.1	Q92608	DOCK2_HUMAN	dedicator of cytokinesis 2	1189	DHR-2.|Interaction with CRKL.				actin cytoskeleton organization|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|endomembrane system|membrane	electron carrier activity|GTP binding|GTPase binding|heme binding|Rac guanyl-nucleotide exchange factor activity|T cell receptor binding			NS(2)|breast(5)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(42)|liver(2)|lung(63)|ovary(5)|pancreas(3)|prostate(7)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)	160	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			TGGATTACCGGGGTGTGATGA	0.582000													10	64					5.50884e-06	6.50666e-06	0.411799	1	0
LRRC4C	57689	broad.mit.edu	37	11	40137641	40137641	+	Missense_Mutation	SNP	G	G	C			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr11:40137641G>C	ENST00000278198.2	-	2	2165	c.202C>G	c.(202-204)Cgt>Ggt	p.R68G	LRRC4C_ENST00000528697.1_Missense_Mutation_p.R68G|LRRC4C_ENST00000530763.1_Missense_Mutation_p.R68G|LRRC4C_ENST00000527150.1_Missense_Mutation_p.R68G			Q9HCJ2	LRC4C_HUMAN	leucine rich repeat containing 4C	68	LRRNT.				regulation of axonogenesis	integral to membrane	protein binding			NS(2)|central_nervous_system(3)|endometrium(1)|large_intestine(14)|lung(43)|ovary(5)|prostate(2)|skin(9)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	86		all_lung(304;0.0575)|Lung NSC(402;0.138)				GGAACCTCACGCAGGTTTTTC	0.527000													15	54					0	0	0.539581	0	0
ITPRIPL2	162073	broad.mit.edu	37	16	19127309	19127309	+	Missense_Mutation	SNP	C	C	T			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr16:19127309C>T	ENST00000381440.3	+	1	2056	c.1526C>T	c.(1525-1527)gCc>gTc	p.A509V	CTD-2349B8.1_ENST00000564808.2_Intron	NM_001034841.3	NP_001030013.1	Q3MIP1	IPIL2_HUMAN	inositol 1,4,5-trisphosphate receptor interacting protein-like 2	509						integral to membrane				endometrium(1)|kidney(1)|large_intestine(1)|lung(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	9						CTTCTCCGGGCCTACGGGGGT	0.682000													7	62					0	0	0.278610	0	0
IL9R	3581	broad.mit.edu	37	X	155239558	155239558	+	Silent	SNP	C	C	T			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chrX:155239558C>T	ENST00000424344.3	+	10	1354	c.987C>T	c.(985-987)ccC>ccT	p.P329P	IL9R_ENST00000369423.2_3'UTR|IL9R_ENST00000540897.1_3'UTR|IL9R_ENST00000244174.5_Silent_p.P350P			Q01113	IL9R_HUMAN	interleukin 9 receptor	350					cell proliferation	extracellular space|integral to plasma membrane	interleukin-9 receptor activity			NS(1)|central_nervous_system(1)|cervix(2)|endometrium(2)|kidney(3)|large_intestine(1)|lung(12)|upper_aerodigestive_tract(1)	23	all_cancers(53;1.86e-17)|all_epithelial(53;2.71e-11)|all_lung(58;1.84e-07)|Lung NSC(58;5.62e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)					CCTTGGAGCCCTGCGTCCAGG	0.672000													3	43					0	0	0.150653	0	0
GLUD1P7	414212	broad.mit.edu	37	10	48968566	48968566	+	RNA	SNP	A	A	G			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr10:48968566A>G	ENST00000594520.1	+	0	723																											ACAGGATAACAAACTGGAAAA	0.318000													3	16					0	0	0.115264	0	0
ENOX2	10495	broad.mit.edu	37	X	129771342	129771342	+	Missense_Mutation	SNP	C	C	A			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chrX:129771342C>A	ENST00000338144.3	-	12	1676	c.1259G>T	c.(1258-1260)aGc>aTc	p.S420I	ENOX2_ENST00000370927.1_Missense_Mutation_p.S420I|ENOX2_ENST00000394363.1_Missense_Mutation_p.S391I|ENOX2_ENST00000370935.1_Missense_Mutation_p.S391I	NM_182314.1	NP_872114.1	Q16206	ENOX2_HUMAN	ecto-NOX disulfide-thiol exchanger 2	420					cell growth|electron transport chain|regulation of growth|transport|ultradian rhythm	cytosol|external side of plasma membrane|extracellular space	nucleic acid binding|nucleotide binding|protein disulfide oxidoreductase activity			breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(17)|ovary(1)|prostate(3)	33						CCAACGGAGGCTGTCATTTTC	0.423000													8	102					0.00448238	0.00487148	0.307466	1	0
PUS3	83480	broad.mit.edu	37	11	125765571	125765571	+	Silent	SNP	G	G	C			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr11:125765571G>C	ENST00000227474.3	-	3	589	c.492C>G	c.(490-492)ctC>ctG	p.L164L	HYLS1_ENST00000425380.2_Intron|PUS3_ENST00000530811.1_Silent_p.L164L|HYLS1_ENST00000356438.3_Intron|HYLS1_ENST00000526028.1_Intron	NM_001271985.1|NM_031307.3	NP_001258914.1|NP_112597.3	Q9BZE2	PUS3_HUMAN	pseudouridylate synthase 3	164						nucleus	RNA binding			NS(1)|large_intestine(3)|lung(4)|ovary(1)|prostate(1)	10	all_hematologic(175;0.177)	Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.131)|all_lung(97;0.139)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.1e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.043)		GTACCCGATTGAGAATGTGGG	0.512000													7	77					0	0	0.307466	0	0
ZDHHC14	79683	broad.mit.edu	37	6	158014145	158014145	+	Missense_Mutation	SNP	G	G	C			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr6:158014145G>C	ENST00000359775.5	+	3	1421	c.532G>C	c.(532-534)Gcc>Ccc	p.A178P	ZDHHC14_ENST00000414563.2_Missense_Mutation_p.A178P|ZDHHC14_ENST00000341375.8_3'UTR			Q8IZN3	ZDH14_HUMAN	zinc finger, DHHC-type containing 14	178						integral to membrane	acyltransferase activity|zinc ion binding			central_nervous_system(1)|endometrium(2)|large_intestine(4)|lung(8)|ovary(1)|skin(1)	17		Breast(66;0.00586)|Ovarian(120;0.123)		OV - Ovarian serous cystadenocarcinoma(65;2.9e-17)|BRCA - Breast invasive adenocarcinoma(81;5.8e-05)		GCCCCCTCGCGCCTCCCATTG	0.597000													19	54					0	0	0.693898	0	0
ACSS3	79611	broad.mit.edu	37	12	81610762	81610762	+	Silent	SNP	C	C	A			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr12:81610762C>A	ENST00000548058.1	+	10	2347	c.1437C>A	c.(1435-1437)gtC>gtA	p.V479V	ACSS3_ENST00000261206.3_Silent_p.V478V|ACSS3_ENST00000548324.1_Silent_p.V161V			Q9H6R3	ACSS3_HUMAN	acyl-CoA synthetase short-chain family member 3	479						mitochondrion	acetate-CoA ligase activity|ATP binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(5)|kidney(2)|large_intestine(7)|liver(3)|lung(20)|ovary(1)|skin(4)|upper_aerodigestive_tract(2)	51						GAAAAAGCGTCCCAGGATACA	0.383000													5	42					0.248553	0.250151	0.248553	1	0
KCNH1	3756	broad.mit.edu	37	1	211093086	211093086	+	Nonsense_Mutation	SNP	G	G	T			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr1:211093086G>T	ENST00000367007.4	-	7	1446	c.1277C>A	c.(1276-1278)tCg>tAg	p.S426*	KCNH1_ENST00000271751.4_Nonsense_Mutation_p.S453*	NM_002238.3|NM_172362.2	NP_002229.1|NP_758872.1	O95259	KCNH1_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 1	453					myoblast fusion|regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	calmodulin binding|delayed rectifier potassium channel activity|two-component sensor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(13)|lung(35)|ovary(4)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	68				OV - Ovarian serous cystadenocarcinoma(81;0.0109)|all cancers(67;0.141)|Epithelial(68;0.185)		GAAATACAACGAGGAGATGTA	0.498000													24	91					6.44725e-10	8.20321e-10	0.624587	1	0
RELN	5649	broad.mit.edu	37	7	103138289	103138289	+	Silent	SNP	C	C	A			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr7:103138289C>A	ENST00000428762.1	-	55	9087	c.8928G>T	c.(8926-8928)ctG>ctT	p.L2976L	RELN_ENST00000424685.2_Silent_p.L2976L|CTB-107G13.1_ENST00000422488.1_RNA|RELN_ENST00000343529.5_Silent_p.L2976L	NM_005045.3	NP_005036.2	P78509	RELN_HUMAN	reelin	2976					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			NS(3)|breast(8)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(43)|lung(101)|ovary(9)|pancreas(2)|prostate(4)|skin(14)|stomach(2)|upper_aerodigestive_tract(12)|urinary_tract(2)	227				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		AGTAGTCCAACAGCACGCCTT	0.527000													7	78					2.17888e-05	2.47996e-05	0.335167	1	0
CXorf23	256643	broad.mit.edu	37	X	19983755	19983755	+	Nonsense_Mutation	SNP	A	A	C			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chrX:19983755A>C	ENST00000379687.3	-	3	714	c.681T>G	c.(679-681)taT>taG	p.Y227*	CXorf23_ENST00000356980.3_Nonsense_Mutation_p.Y227*|CXorf23_ENST00000379682.4_Nonsense_Mutation_p.Y227*	NM_198279.3	NP_938020.2	A2AJT9	CX023_HUMAN	chromosome X open reading frame 23	227						mitochondrion				endometrium(2)|large_intestine(1)|lung(6)|skin(1)|urinary_tract(1)	11						CTCTGCTTTCATACCTCTCCA	0.478000													14	126					0	0	0.479597	0	0
AKAP6	9472	broad.mit.edu	37	14	33015129	33015129	+	Missense_Mutation	SNP	A	A	T			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr14:33015129A>T	ENST00000280979.4	+	4	1440	c.1270A>T	c.(1270-1272)Agc>Tgc	p.S424C	AKAP6_ENST00000557354.1_Missense_Mutation_p.S424C|AKAP6_ENST00000557272.1_Missense_Mutation_p.S424C	NM_004274.4	NP_004265.3	Q13023	AKAP6_HUMAN	A kinase (PRKA) anchor protein 6	424					protein targeting	calcium channel complex|nuclear membrane|sarcoplasmic reticulum	protein kinase A binding|receptor binding			NS(2)|breast(10)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(25)|lung(42)|ovary(5)|pancreas(2)|prostate(3)|skin(9)|urinary_tract(2)	122	Breast(36;0.0388)|Prostate(35;0.15)		LUAD - Lung adenocarcinoma(48;0.00107)|Lung(238;0.00677)|STAD - Stomach adenocarcinoma(7;0.116)	GBM - Glioblastoma multiforme(265;0.019)		GATGAGCAGAAGCACCCCTTC	0.443000													25	174					0	0	0.717897	0	0
RNF180	285671	broad.mit.edu	37	5	63510244	63510244	+	Nonsense_Mutation	SNP	C	C	A			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr5:63510244C>A	ENST00000389100.4	+	4	1163	c.1091C>A	c.(1090-1092)tCa>tAa	p.S364*	RNF180_ENST00000296615.6_Nonsense_Mutation_p.S364*|RNF180_ENST00000381081.2_Intron	NM_001113561.1	NP_001107033.1	Q86T96	RN180_HUMAN	ring finger protein 180	364	Interaction with ZIC2 (By similarity).					integral to membrane|nuclear envelope	zinc ion binding			breast(1)|kidney(1)|large_intestine(4)|lung(9)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	20		Lung NSC(810;3.55e-06)|Prostate(74;0.0352)|Ovarian(174;0.0545)|Breast(144;0.0848)|Colorectal(97;0.234)		Lung(70;0.114)		GCCAATTTTTCATTGGGCAGC	0.507000													7	50					1.12685e-05	1.31606e-05	0.307466	1	0
SORL1	6653	broad.mit.edu	37	11	121474959	121474959	+	Missense_Mutation	SNP	C	C	T			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr11:121474959C>T	ENST00000260197.7	+	33	4706	c.4577C>T	c.(4576-4578)gCc>gTc	p.A1526V	SORL1_ENST00000525532.1_Missense_Mutation_p.A470V|SORL1_ENST00000532694.1_Missense_Mutation_p.A372V|SORL1_ENST00000534286.1_Missense_Mutation_p.A436V|SORL1_ENST00000527934.1_Missense_Mutation_p.A141V	NM_003105.5	NP_003096.1	Q92673	SORL_HUMAN	sortilin-related receptor, L(DLR class) A repeats containing	1526	LDL-receptor class A 11.				cholesterol metabolic process|lipid transport|receptor-mediated endocytosis	integral to plasma membrane|low-density lipoprotein particle	low-density lipoprotein particle binding|transmembrane receptor activity			NS(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|liver(2)|lung(34)|ovary(5)|pancreas(1)|skin(12)|stomach(2)|upper_aerodigestive_tract(2)	91		Breast(109;0.00119)|Medulloblastoma(222;0.0429)|all_neural(223;0.113)		BRCA - Breast invasive adenocarcinoma(274;3.34e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.108)		GACGGGGAGGCCTGCATTGTG	0.627000													28	132					0	0	0.827153	0	0
APOB	338	broad.mit.edu	37	2	21233694	21233694	+	Missense_Mutation	SNP	C	C	A			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr2:21233694C>A	ENST00000233242.1	-	26	6173	c.6046G>T	c.(6046-6048)Gac>Tac	p.D2016Y		NM_000384.2	NP_000375.2	P04114	APOB_HUMAN	apolipoprotein B	2016					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			NS(5)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(19)|kidney(10)|large_intestine(63)|liver(5)|lung(125)|ovary(16)|pancreas(1)|prostate(5)|skin(31)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(6)	305	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	AGAGTTAGGTCAGCCAGAGTT	0.428000													33	64					2.87052e-16	3.88949e-16	0.812448	1	0
ELN	2006	broad.mit.edu	37	7	73470724	73470724	+	Missense_Mutation	SNP	G	G	C			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr7:73470724G>C	ENST00000252034.7	+	20	1673	c.1274G>C	c.(1273-1275)gGt>gCt	p.G425A	ELN_ENST00000380584.4_Missense_Mutation_p.G411A|ELN_ENST00000380562.4_Missense_Mutation_p.G425A|ELN_ENST00000429192.1_Missense_Mutation_p.G430A|ELN_ENST00000414324.1_Missense_Mutation_p.G420A|ELN_ENST00000380553.4_Missense_Mutation_p.G308A|ELN_ENST00000358929.4_Missense_Mutation_p.G425A|ELN_ENST00000380575.4_Missense_Mutation_p.G415A|ELN_ENST00000380576.5_Missense_Mutation_p.G425A|ELN_ENST00000357036.5_Missense_Mutation_p.G430A|ELN_ENST00000445912.1_Missense_Mutation_p.G425A|ELN_ENST00000458204.1_Missense_Mutation_p.G415A|ELN_ENST00000320399.6_Missense_Mutation_p.G425A|ELN_ENST00000320492.7_Intron	NM_000501.2	NP_000492.2	P15502	ELN_HUMAN	elastin	425	Ala-rich.				blood circulation|cell proliferation|organ morphogenesis|respiratory gaseous exchange	proteinaceous extracellular matrix	extracellular matrix constituent conferring elasticity|protein binding			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(10)|ovary(4)|pancreas(2)|prostate(1)|skin(2)|stomach(1)	32		Lung NSC(55;0.159)			Rofecoxib(DB00533)	GGTGTCGGAGGTGTTCCCGGA	0.617000			T	PAX5	B-ALL		"""Supravalvular Aortic Stenosis, Cutis laxa , Williams-Beuren Syndrome"""						29	89					0	0	0.779181	0	0
SEMA3D	223117	broad.mit.edu	37	7	84751195	84751195	+	Missense_Mutation	SNP	T	T	C			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr7:84751195T>C	ENST00000284136.6	-	1	56	c.13A>G	c.(13-15)Aaa>Gaa	p.K5E	SEMA3D_ENST00000444867.1_Missense_Mutation_p.K5E	NM_152754.2	NP_689967.2	O95025	SEM3D_HUMAN	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D	5					cell differentiation|nervous system development	extracellular region|membrane	receptor activity			NS(1)|breast(2)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(19)|lung(29)|ovary(3)|pancreas(1)|prostate(4)|skin(2)	73						CTTTCATCTTTATTAGCATTC	0.318000													4	20					0	0	0.217242	0	0
BTAF1	9044	broad.mit.edu	37	10	93784690	93784690	+	Missense_Mutation	SNP	A	A	G			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr10:93784690A>G	ENST00000265990.6	+	35	5349	c.5041A>G	c.(5041-5043)Ata>Gta	p.I1681V	BTAF1_ENST00000544642.1_Missense_Mutation_p.I509V	NM_003972.2	NP_003963.1	O14981	BTAF1_HUMAN	BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa	1681	Helicase C-terminal.				negative regulation of transcription, DNA-dependent	nucleus	ATP binding|DNA binding|helicase activity|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(17)|lung(17)|ovary(1)|prostate(1)|skin(2)|urinary_tract(6)	59		Colorectal(252;0.0846)				AGATGGCAGCATACCTCCTGG	0.393000													34	101					0	0	0.870114	0	0
FOXP2	93986	broad.mit.edu	37	7	114302233	114302233	+	Missense_Mutation	SNP	G	G	T			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr7:114302233G>T	ENST00000408937.3	+	15	2210	c.1836G>T	c.(1834-1836)aaG>aaT	p.K612N	FOXP2_ENST00000403559.4_Missense_Mutation_p.K604N|FOXP2_ENST00000393494.2_Missense_Mutation_p.K587N|FOXP2_ENST00000393491.3_Missense_Mutation_p.K402N|FOXP2_ENST00000393489.3_Missense_Mutation_p.K495N|FOXP2_ENST00000393500.3_3'UTR|FOXP2_ENST00000350908.4_Missense_Mutation_p.K587N|FOXP2_ENST00000393498.2_Missense_Mutation_p.K566N	NM_001172766.2|NM_014491.3|NM_148898.3	NP_001166237.1|NP_055306.1|NP_683696.2	O15409	FOXP2_HUMAN	forkhead box P2	587					camera-type eye development|caudate nucleus development|cerebellum development|cerebral cortex development|embryo development|growth|lung alveolus development|negative regulation of transcription, DNA-dependent|pattern specification process|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of mesenchymal cell proliferation|post-embryonic development|putamen development|regulation of sequence-specific DNA binding transcription factor activity|righting reflex|skeletal muscle tissue development|smooth muscle tissue development|vocal learning	cytoplasm|transcription factor complex	chromatin binding|DNA bending activity|double-stranded DNA binding|promoter binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|zinc ion binding			breast(3)|endometrium(7)|kidney(4)|large_intestine(7)|lung(22)|ovary(4)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	52						GGTCACAAAAGATAACAGGGT	0.413000													8	77					5.18039e-06	6.1419e-06	0.278610	1	0
GNA11	2767	broad.mit.edu	37	19	3113402	3113402	+	Missense_Mutation	SNP	C	C	G			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr19:3113402C>G	ENST00000078429.4	+	3	638	c.396C>G	c.(394-396)atC>atG	p.I132M		NM_002067.2	NP_002058.2	P29992	GNA11_HUMAN	guanine nucleotide binding protein (G protein), alpha 11 (Gq class)	132					activation of phospholipase C activity by dopamine receptor signaling pathway|G-protein signaling, coupled to cAMP nucleotide second messenger|platelet activation|protein ADP-ribosylation|regulation of action potential	cytoplasm|heterotrimeric G-protein complex	G-protein beta/gamma-subunit complex binding|G-protein-coupled receptor binding|GTP binding|GTPase activity|signal transducer activity			endometrium(2)|eye(132)|kidney(1)|large_intestine(2)|lung(1)|meninges(5)|ovary(1)|prostate(1)|skin(16)	161		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.79e-05)|OV - Ovarian serous cystadenocarcinoma(105;2.68e-113)|Epithelial(107;1.22e-111)|all cancers(105;5.78e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00141)|STAD - Stomach adenocarcinoma(1328;0.181)		TCAGTGCCATCAAGACCCTGT	0.642000			Mis		uveal melanoma								5	40					0	0	0.278610	0	0
FAM134B	54463	broad.mit.edu	37	5	16477806	16477806	+	Nonsense_Mutation	SNP	G	G	C			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr5:16477806G>C	ENST00000306320.9	-	8	1051	c.965C>G	c.(964-966)tCa>tGa	p.S322*	FAM134B_ENST00000399793.2_Nonsense_Mutation_p.S181*	NM_001034850.2	NP_001030022.1	Q9H6L5	F134B_HUMAN	family with sequence similarity 134, member B	322					sensory perception of pain	cis-Golgi network|endoplasmic reticulum|integral to membrane				breast(1)|kidney(1)|large_intestine(4)|lung(5)|ovary(2)|prostate(2)|skin(1)	16						GTATCCTTCTGAAAGGTTGAA	0.408000													7	119					0	0	0.248553	0	0
USH2A	7399	broad.mit.edu	37	1	215824116	215824116	+	Missense_Mutation	SNP	C	C	A			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr1:215824116C>A	ENST00000366943.2	-	65	14547	c.14161G>T	c.(14161-14163)Gcc>Tcc	p.A4721S	USH2A_ENST00000307340.3_Missense_Mutation_p.A4721S			O75445	USH2A_HUMAN	Usher syndrome 2A (autosomal recessive, mild)	4721	Fibronectin type-III 32.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			NS(7)|breast(20)|central_nervous_system(3)|cervix(2)|endometrium(32)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(71)|liver(2)|lung(282)|ovary(25)|pancreas(2)|prostate(12)|skin(22)|stomach(7)|upper_aerodigestive_tract(20)|urinary_tract(3)	527				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		CTACTGGGGGCTTTTCCTGCA	0.493000										HNSCC(13;0.011)			34	90					2.20474e-14	2.89951e-14	0.788014	1	0
LINGO1	84894	broad.mit.edu	37	15	77908159	77908159	+	Silent	SNP	C	C	T			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr15:77908159C>T	ENST00000355300.6	-	2	264	c.90G>A	c.(88-90)gtG>gtA	p.V30V	LINGO1_ENST00000561030.1_Silent_p.V24V	NM_032808.5	NP_116197.4	Q96FE5	LIGO1_HUMAN	leucine rich repeat and Ig domain containing 1	30					negative regulation of axonogenesis|nerve growth factor receptor signaling pathway	integral to membrane|plasma membrane				breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(16)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	31						CTGAGCCCAGCACCAGCAGGA	0.716000													3	7					0	0	0.150653	0	0
SLC39A12	221074	broad.mit.edu	37	10	18280162	18280162	+	Nonsense_Mutation	SNP	T	T	A			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr10:18280162T>A	ENST00000377369.2	+	8	1625	c.1352T>A	c.(1351-1353)tTa>tAa	p.L451*	SLC39A12_ENST00000377374.4_Nonsense_Mutation_p.L451*|SLC39A12_ENST00000377371.3_Nonsense_Mutation_p.L451*|SLC39A12_ENST00000539911.1_Nonsense_Mutation_p.L317*	NM_001145195.1	NP_001138667.1	Q504Y0	S39AC_HUMAN	solute carrier family 39 (zinc transporter), member 12	451					zinc ion transport	integral to membrane	metal ion transmembrane transporter activity			NS(1)|breast(4)|central_nervous_system(1)|cervix(1)|kidney(3)|large_intestine(5)|lung(38)|ovary(3)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	60						CTGATGGGATTAATTGGAGGC	0.343000													3	17					0	0	0.115264	0	0
SLC25A14	9016	broad.mit.edu	37	X	129474255	129474255	+	Translation_Start_Site	SNP	G	G	T			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chrX:129474255G>T	ENST00000218197.5	+	1	230	c.3G>T	c.(1-3)atG>atT	p.M1I	SLC25A14_ENST00000543953.1_Intron|SLC25A14_ENST00000361980.5_Start_Codon_SNP_p.M1I|SLC25A14_ENST00000339231.3_Start_Codon_SNP_p.M1I|SLC25A14_ENST00000467496.1_3'UTR|SLC25A14_ENST00000545805.1_Start_Codon_SNP_p.M1I	NM_003951.2|NM_022810.1	NP_003942.1|NP_073721.1	O95258	UCP5_HUMAN	solute carrier family 25 (mitochondrial carrier, brain), member 14	1					aerobic respiration|mitochondrial transport	integral to plasma membrane|mitochondrial inner membrane	binding			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(7)|ovary(1)	22						GAGGGTGAATGGGTATCTTTC	0.537000													18	140					3.51602e-12	4.54757e-12	0.575678	1	0
TCP11L1	55346	broad.mit.edu	37	11	33094160	33094160	+	Missense_Mutation	SNP	A	A	G			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr11:33094160A>G	ENST00000334274.4	+	10	1868	c.1468A>G	c.(1468-1470)Aac>Gac	p.N490D	TCP11L1_ENST00000324357.9_Missense_Mutation_p.N269D|TCP11L1_ENST00000432887.1_Missense_Mutation_p.N490D|TCP11L1_ENST00000531632.2_Missense_Mutation_p.N490D	NM_018393.3	NP_060863.3	Q9NUJ3	T11L1_HUMAN	t-complex 11, testis-specific-like 1	490										kidney(1)|liver(2)|lung(2)|skin(1)	6						GGTCAACTATAACAAGATGGT	0.498000													15	108					0	0	0.557998	0	0
BRE	9577	broad.mit.edu	37	2	28210901	28210901	+	Missense_Mutation	SNP	G	G	A			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr2:28210901G>A	ENST00000344773.2	+	4	385	c.247G>A	c.(247-249)Gat>Aat	p.D83N	BRE_ENST00000361704.2_Missense_Mutation_p.D83N|BRE_ENST00000379624.1_Missense_Mutation_p.D83N|BRE_ENST00000379632.2_Missense_Mutation_p.D83N|BRE_ENST00000342045.2_Missense_Mutation_p.D83N|BRE_ENST00000603461.1_3'UTR	NM_004899.4	NP_004890.2	Q9NXR7	BRE_HUMAN	brain and reproductive organ-expressed (TNFRSF1A modulator)	83	UEV-like 1.				apoptosis|chromatin modification|double-strand break repair|G2/M transition DNA damage checkpoint|positive regulation of anti-apoptosis|positive regulation of DNA repair|response to ionizing radiation|signal transduction	BRCA1-A complex|BRISC complex|cytoplasm|nuclear ubiquitin ligase complex	peroxisome targeting sequence binding|polyubiquitin binding|tumor necrosis factor receptor binding			NS(1)|endometrium(3)|kidney(2)|large_intestine(2)|lung(11)|prostate(2)|skin(2)	23	Acute lymphoblastic leukemia(172;0.155)					ACTGCCTCCCGATTTTATCTT	0.398000													23	278					0	0	0.693898	0	0
VTN	7448	broad.mit.edu	37	17	26696336	26696336	+	Missense_Mutation	SNP	A	A	T			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr17:26696336A>T	ENST00000226218.4	-	4	1261	c.643T>A	c.(643-645)Tgt>Agt	p.C215S	SARM1_ENST00000379061.4_Intron|TMEM199_ENST00000509083.1_Intron|CTB-96E2.3_ENST00000591482.1_RNA|SEBOX_ENST00000536498.1_5'UTR	NM_000638.3	NP_000629.3	P04004	VTNC_HUMAN	vitronectin	215	Hemopexin-like 2.				cell adhesion mediated by integrin|immune response|negative regulation of endopeptidase activity|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of protein binding|positive regulation of receptor-mediated endocytosis|positive regulation of smooth muscle cell migration|positive regulation of vascular endothelial growth factor receptor signaling pathway|smooth muscle cell-matrix adhesion	alphav-beta3 integrin-vitronectin complex|extracellular space	heparin binding|integrin binding|scavenger receptor activity			kidney(2)|large_intestine(7)|lung(2)|ovary(1)|upper_aerodigestive_tract(1)	13	all_lung(13;0.000533)|Lung NSC(42;0.00171)			UCEC - Uterine corpus endometrioid carcinoma (53;0.153)	Urokinase(DB00013)	TTCCCCTGACAGTTGATGCGG	0.597000													9	103					0	0	0.387290	0	0
SGCZ	137868	broad.mit.edu	37	8	13959957	13959957	+	Missense_Mutation	SNP	C	C	A			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr8:13959957C>A	ENST00000382080.1	-	7	1387	c.672G>T	c.(670-672)caG>caT	p.Q224H	SGCZ_ENST00000421524.2_Missense_Mutation_p.Q177H	NM_139167.2	NP_631906.2	Q96LD1	SGCZ_HUMAN	sarcoglycan, zeta	211					cytoskeleton organization	cytoplasm|cytoskeleton|integral to membrane|sarcolemma				NS(1)|central_nervous_system(2)|endometrium(1)|kidney(3)|large_intestine(14)|lung(15)|ovary(2)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)	47				all cancers(2;0.000643)|Colorectal(111;0.00674)|COAD - Colon adenocarcinoma(73;0.0193)|GBM - Glioblastoma multiforme(2;0.026)		CAGCACTCACCTGGACCCCAC	0.488000													3	17					0.115264	0.118287	0.115264	1	0
SEC24A	10802	broad.mit.edu	37	5	133997053	133997053	+	Missense_Mutation	SNP	G	G	T			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr5:133997053G>T	ENST00000398844.2	+	2	630	c.342G>T	c.(340-342)caG>caT	p.Q114H	SEC24A_ENST00000322887.4_Missense_Mutation_p.Q114H	NM_021982.2	NP_068817.1	O95486	SC24A_HUMAN	SEC24 family member A	114	Pro-rich.				COPII vesicle coating|intracellular protein transport|post-translational protein modification|protein N-linked glycosylation via asparagine	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|Golgi membrane|perinuclear region of cytoplasm	zinc ion binding			NS(1)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(4)|lung(13)|ovary(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	36			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			CTGCTTCTCAGAACCCAGCTA	0.498000													13	90					2.31682e-05	2.62741e-05	0.479597	1	0
ATP7A	538	broad.mit.edu	37	X	77268489	77268489	+	Silent	SNP	G	G	A			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chrX:77268489G>A	ENST00000341514.6	+	10	2441	c.2286G>A	c.(2284-2286)ttG>ttA	p.L762L	ATP7A_ENST00000350425.4_Intron|ATP7A_ENST00000343533.5_Intron	NM_000052.5	NP_000043.3	Q04656	ATP7A_HUMAN	ATPase, Cu++ transporting, alpha polypeptide	762					ATP biosynthetic process|blood vessel development|blood vessel remodeling|cartilage development|cellular copper ion homeostasis|cerebellar Purkinje cell differentiation|collagen fibril organization|copper ion import|detoxification of copper ion|dopamine metabolic process|elastic fiber assembly|elastin biosynthetic process|epinephrine metabolic process|hair follicle morphogenesis|locomotory behavior|lung alveolus development|negative regulation of metalloenzyme activity|neuroprotection|peptidyl-lysine modification|pigmentation|positive regulation of metalloenzyme activity|positive regulation of oxidoreductase activity|pyramidal neuron development|regulation of oxidative phosphorylation|removal of superoxide radicals|serotonin metabolic process|skin development|T-helper cell differentiation|tryptophan metabolic process	basolateral plasma membrane|cytosol|endoplasmic reticulum|integral to membrane|late endosome|neuron projection|neuronal cell body|perinuclear region of cytoplasm|trans-Golgi network|trans-Golgi network transport vesicle	ATP binding|copper-dependent protein binding|copper-exporting ATPase activity|superoxide dismutase copper chaperone activity			breast(4)|central_nervous_system(3)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(26)|pancreas(1)|prostate(1)|urinary_tract(1)	53						CCTACTCTTTGATTATTCTTC	0.413000													21	288					0	0	0.681144	0	0
CAPN6	827	broad.mit.edu	37	X	110494264	110494264	+	Missense_Mutation	SNP	T	T	C			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chrX:110494264T>C	ENST00000324068.1	-	8	1206	c.1039A>G	c.(1039-1041)Att>Gtt	p.I347V	CAPN6_ENST00000541758.1_Missense_Mutation_p.I92V	NM_014289.3	NP_055104.2	Q9Y6Q1	CAN6_HUMAN	calpain 6	347	Domain III.				microtubule bundle formation|proteolysis|regulation of cytoskeleton organization	perinuclear region of cytoplasm|spindle microtubule	calcium-dependent cysteine-type endopeptidase activity|microtubule binding			cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(25)|ovary(3)|skin(3)|upper_aerodigestive_tract(1)	47						CGGCCAAAAATAGGGTTGTTC	0.478000													47	489					0	0	0.870114	0	0
GLP1R	2740	broad.mit.edu	37	6	39053762	39053762	+	Silent	SNP	C	C	G			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr6:39053762C>G	ENST00000373256.4	+	13	1348	c.1305C>G	c.(1303-1305)ccC>ccG	p.P435P		NM_002062.3	NP_002053.3	P43220	GLP1R_HUMAN	glucagon-like peptide 1 receptor	435					activation of adenylate cyclase activity|cAMP-mediated signaling|elevation of cytosolic calcium ion concentration|energy reserve metabolic process|regulation of insulin secretion	integral to membrane|plasma membrane	glucagon receptor activity|peptide receptor activity, G-protein coupled			breast(5)|endometrium(3)|kidney(1)|large_intestine(8)|lung(9)|pancreas(1)|prostate(1)|skin(1)|stomach(2)	31					Exenatide(DB01276)|Glucagon recombinant(DB00040)	GCATGAAGCCCCTCAAGTGTC	0.622000													10	125					0	0	0.387290	0	0
EPHA10	284656	broad.mit.edu	37	1	38227381	38227381	+	Silent	SNP	C	C	T			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr1:38227381C>T	ENST00000373048.4	-	3	545	c.546G>A	c.(544-546)ccG>ccA	p.P182P	EPHA10_ENST00000427468.2_Silent_p.P182P|EPHA10_ENST00000319637.6_Silent_p.P182P	NM_001099439.1	NP_001092909.1	Q5JZY3	EPHAA_HUMAN	EPH receptor A10	182						extracellular region|integral to membrane|integral to plasma membrane	ATP binding|ephrin receptor activity|protein binding|transmembrane-ephrin receptor activity	p.P182P(1)		NS(2)|breast(4)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(4)|lung(13)|prostate(3)|skin(8)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	50	Acute lymphoblastic leukemia(166;0.074)|all_hematologic(146;0.197)	Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				GCCGGCTGAGCGGTCCGATCT	0.657000													4	79					0	0	0.217242	0	0
PRPS2	5634	broad.mit.edu	37	X	12817442	12817442	+	Missense_Mutation	SNP	C	C	A	rs11542625		TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chrX:12817442C>A	ENST00000380668.5	+	2	367	c.239C>A	c.(238-240)gCg>gAg	p.A80E	PRPS2_ENST00000398491.2_Missense_Mutation_p.A80E|PRPS2_ENST00000489404.1_Missense_Mutation_p.A80E	NM_001039091.2|NM_002765.4	NP_001034180.1|NP_002756.1	P11908	PRPS2_HUMAN	phosphoribosyl pyrophosphate synthetase 2	80					nucleoside metabolic process|ribonucleoside monophosphate biosynthetic process		ATP binding|kinase activity|magnesium ion binding|protein homodimerization activity|ribose phosphate diphosphokinase activity			breast(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(5)|urinary_tract(1)	16						TGCAAGATTGCGTCATCATCC	0.507000													20	200					2.27525e-19	3.16513e-19	0.667858	1	0
HSPA4	3308	broad.mit.edu	37	5	132424158	132424158	+	Missense_Mutation	SNP	G	G	T			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr5:132424158G>T	ENST00000304858.2	+	9	1337	c.1048G>T	c.(1048-1050)Gta>Tta	p.V350L	HSPA4_ENST00000504328.1_3'UTR	NM_002154.3	NP_002145.3	P34932	HSP74_HUMAN	heat shock 70kDa protein 4	350					cellular chaperone-mediated protein complex assembly|protein import into mitochondrial outer membrane|response to unfolded protein	cytoplasm|nucleus	ATP binding			NS(2)|breast(4)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(9)|lung(10)|stomach(1)	32			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			AATCCCTGCGGTAAAAGAGAA	0.348000													7	59					5.4927e-09	6.82229e-09	0.307466	1	0
ZNF319	57567	broad.mit.edu	37	16	58031336	58031336	+	Silent	SNP	G	G	A			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr16:58031336G>A	ENST00000299237.2	-	2	1456	c.834C>T	c.(832-834)taC>taT	p.Y278Y		NM_020807.1	NP_065858.1	Q9P2F9	ZN319_HUMAN	zinc finger protein 319	278					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(2)|lung(4)|ovary(1)|urinary_tract(1)	8						CCGAGTGCGCGTACATGTGGC	0.637000													3	54					0	0	0.184627	0	0
MDFIC	29969	broad.mit.edu	37	7	114619572	114619572	+	Missense_Mutation	SNP	C	C	T			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr7:114619572C>T	ENST00000257724.3	+	4	819	c.556C>T	c.(556-558)Cgc>Tgc	p.R186C	MDFIC_ENST00000393486.1_Missense_Mutation_p.R77C			Q9P1T7	MDFIC_HUMAN	MyoD family inhibitor domain containing	77	Cys-rich.				activation of JUN kinase activity|interspecies interaction between organisms|negative regulation of protein import into nucleus|negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|positive regulation of viral transcription|regulation of Wnt receptor signaling pathway|transcription, DNA-dependent	cytoplasm|nucleolus|nucleus	cyclin binding|Tat protein binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(2)|ovary(1)	8						CCAACCTCAGCGCTTGCCTCA	0.383000													3	56					0	0	0.150653	0	0
CASC3	22794	broad.mit.edu	37	17	38297833	38297833	+	Silent	SNP	G	G	T			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr17:38297833G>T	ENST00000264645.7	+	3	496	c.270G>T	c.(268-270)tcG>tcT	p.S90S		NM_007359.4	NP_031385.2	O15234	CASC3_HUMAN	cancer susceptibility candidate 3	90					mRNA processing|mRNA transport|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of translation|response to stress|RNA splicing	exon-exon junction complex|nuclear speck|perinuclear region of cytoplasm	identical protein binding|RNA binding|ubiquitin protein ligase binding			endometrium(4)|kidney(2)|large_intestine(3)|lung(4)|ovary(1)|urinary_tract(2)	16						CTGTTCTCTCGGATTATGAAA	0.358000													27	85					6.00712e-18	8.24662e-18	0.760397	1	0
RRBP1	6238	broad.mit.edu	37	20	17639463	17639463	+	Missense_Mutation	SNP	T	T	A			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr20:17639463T>A	ENST00000377813.1	-	3	1993	c.1690A>T	c.(1690-1692)Aca>Tca	p.T564S	RRBP1_ENST00000377807.2_Intron|RRBP1_ENST00000360807.4_Intron|RRBP1_ENST00000455029.2_Intron|RRBP1_ENST00000246043.4_Missense_Mutation_p.T564S			Q9P2E9	RRBP1_HUMAN	ribosome binding protein 1	564	41 X 10 AA approximate tandem repeats of [TN]-Q-[GSA]-[KRQT]-K-[ATGSV]-[ED]- [GTAS]-[ATIS]-[PQTAS].				protein transport|translation|transmembrane transport	integral to endoplasmic reticulum membrane|ribosome	receptor activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(9)|ovary(2)|prostate(6)	28						CCCTGGTTTGTAATACCCTCT	0.527000													3	51					0	0	0.184627	0	0
LPCAT2	54947	broad.mit.edu	37	16	55568378	55568378	+	Silent	SNP	A	A	G			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr16:55568378A>G	ENST00000262134.5	+	7	970	c.786A>G	c.(784-786)caA>caG	p.Q262Q		NM_017839.4	NP_060309.2	Q7L5N7	PCAT2_HUMAN	lysophosphatidylcholine acyltransferase 2	262					cellular membrane organization|platelet activating factor biosynthetic process	endoplasmic reticulum membrane|Golgi membrane|Golgi stack|integral to membrane	1-acylglycerophosphocholine O-acyltransferase activity|1-alkylglycerophosphocholine O-acetyltransferase activity|calcium ion binding			endometrium(2)|kidney(1)|large_intestine(3)|lung(5)|prostate(1)	12						GGACATGGCAAGGATATACAT	0.239000													8	76					0	0	0.361761	0	0
BEST3	144453	broad.mit.edu	37	12	70049365	70049365	+	Silent	SNP	G	G	A			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr12:70049365G>A	ENST00000330891.5	-	10	1555	c.1329C>T	c.(1327-1329)ccC>ccT	p.P443P	BEST3_ENST00000488961.1_Silent_p.P230P|BEST3_ENST00000331471.4_Intron|BEST3_ENST00000553096.1_Silent_p.P337P	NM_032735.2	NP_116124.2	Q8N1M1	BEST3_HUMAN	bestrophin 3	443						chloride channel complex|plasma membrane	chloride channel activity			cervix(2)|endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|prostate(1)|skin(2)	12	Breast(13;2.31e-06)|Esophageal squamous(21;0.187)		Lung(24;0.000278)|OV - Ovarian serous cystadenocarcinoma(12;0.0019)|STAD - Stomach adenocarcinoma(21;0.00694)			AGGCCCTGGGGGGGTTTCTTG	0.592000													4	54					0	0	0.184627	0	0
OR4N5	390437	broad.mit.edu	37	14	20612483	20612483	+	Missense_Mutation	SNP	C	C	T			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr14:20612483C>T	ENST00000333629.1	+	1	589	c.589C>T	c.(589-591)Ctt>Ttt	p.L197F		NM_001004724.1	NP_001004724.1	Q8IXE1	OR4N5_HUMAN	olfactory receptor, family 4, subfamily N, member 5	197					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|lung(23)|ovary(1)|skin(2)|urinary_tract(1)	29	all_cancers(95;0.00108)		Epithelial(56;7.58e-07)|all cancers(55;3.84e-06)	GBM - Glioblastoma multiforme(265;0.0143)		TGTGGTGGAGCTTCTGATGGT	0.547000													5	39					0	0	0.184627	0	0
MAGI1	9223	broad.mit.edu	37	3	65342324	65342324	+	Missense_Mutation	SNP	G	G	A			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr3:65342324G>A	ENST00000402939.2	-	23	4117	c.4118C>T	c.(4117-4119)tCt>tTt	p.S1373F	MAGI1_ENST00000330909.8_3'UTR	NM_001033057.1	NP_001028229.1	Q96QZ7	MAGI1_HUMAN	membrane associated guanylate kinase, WW and PDZ domain containing 1	1402					cell adhesion|cell surface receptor linked signaling pathway|protein complex assembly	tight junction	ATP binding|protein C-terminus binding			breast(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|liver(1)|lung(21)|pancreas(1)|skin(5)	51		Lung NSC(201;0.0016)		BRCA - Breast invasive adenocarcinoma(55;0.00138)|KIRC - Kidney renal clear cell carcinoma(15;0.0988)|Kidney(15;0.133)		TCTCTCCAGAGACCGTCTCCG	0.711000													4	29					0	0	0.184627	0	0
MTHFD1L	25902	broad.mit.edu	37	6	151247397	151247397	+	Missense_Mutation	SNP	G	G	A			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr6:151247397G>A	ENST00000367321.3	+	11	1496	c.1222G>A	c.(1222-1224)Gat>Aat	p.D408N		NM_001242767.1|NM_001242768.1|NM_015440.4	NP_001229696.1|NP_001229697.1|NP_056255.2	Q6UB35	C1TM_HUMAN	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like	408	Formyltetrahydrofolate synthetase.				folic acid-containing compound biosynthetic process|formate metabolic process|one-carbon metabolic process|tetrahydrofolate metabolic process	mitochondrion	ATP binding|formate-tetrahydrofolate ligase activity|protein homodimerization activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(12)|lung(8)|ovary(3)|prostate(1)|upper_aerodigestive_tract(2)	29		Ovarian(120;0.128)		OV - Ovarian serous cystadenocarcinoma(155;8.7e-12)		AAGGTTAAAGGATCAAGCAGA	0.393000													16	102					0	0	0.592651	0	0
DMD	1756	broad.mit.edu	37	X	31496475	31496475	+	Missense_Mutation	SNP	C	C	G			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chrX:31496475C>G	ENST00000357033.4	-	59	8891	c.8685G>C	c.(8683-8685)gaG>gaC	p.E2895D	DMD_ENST00000359836.1_Missense_Mutation_p.E435D|DMD_ENST00000378707.3_Missense_Mutation_p.E435D|DMD_ENST00000445312.1_5'UTR|DMD_ENST00000474231.1_Missense_Mutation_p.E435D|DMD_ENST00000343523.2_Missense_Mutation_p.E435D|DMD_ENST00000378677.2_Missense_Mutation_p.E2891D|DMD_ENST00000541735.1_Missense_Mutation_p.E435D	NM_000109.3|NM_004006.2|NM_004007.2|NM_004011.3|NM_004012.3|NM_004014.2	NP_000100.2|NP_003997.1|NP_003998.1|NP_004002.2|NP_004003.1|NP_004005.1	P11532	DMD_HUMAN	dystrophin	2895					muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			NS(2)|breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(17)|liver(1)|lung(25)|ovary(3)|pancreas(3)|prostate(2)|skin(1)|urinary_tract(2)	77		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				TCTGGGCTCTCTCCTCAGGAG	0.433000													20	89					0	0	0.667858	0	0
SYNE1	23345	broad.mit.edu	37	6	152563539	152563539	+	Missense_Mutation	SNP	G	G	A			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr6:152563539G>A	ENST00000367255.5	-	107	20330	c.19729C>T	c.(19729-19731)Cgg>Tgg	p.R6577W	SYNE1_ENST00000356820.4_Missense_Mutation_p.R1101W|SYNE1_ENST00000448038.1_Missense_Mutation_p.R6506W|SYNE1_ENST00000341594.5_Missense_Mutation_p.R6189W|SYNE1_ENST00000423061.1_Missense_Mutation_p.R6506W|SYNE1_ENST00000265368.4_Missense_Mutation_p.R6577W	NM_182961.3	NP_892006.3	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	6577					cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			NS(3)|biliary_tract(1)|breast(17)|central_nervous_system(21)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(4)|kidney(16)|large_intestine(138)|liver(1)|lung(190)|ovary(11)|pancreas(5)|prostate(12)|skin(20)|stomach(3)|upper_aerodigestive_tract(33)|urinary_tract(19)	524		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		CCACTCCTCCGGGAGCCAATG	0.468000										HNSCC(10;0.0054)			25	72					0	0	0.729181	0	0
MYO5C	55930	broad.mit.edu	37	15	52553230	52553230	+	Missense_Mutation	SNP	C	C	A			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr15:52553230C>A	ENST00000261839.7	-	10	1303	c.1142G>T	c.(1141-1143)aGc>aTc	p.S381I	MYO5C_ENST00000443683.2_Missense_Mutation_p.S324I|MYO5C_ENST00000541028.1_5'UTR	NM_018728.3	NP_061198.2	Q9NQX4	MYO5C_HUMAN	myosin VC	381	Myosin head-like.					myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(8)|kidney(7)|large_intestine(15)|lung(12)|ovary(7)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	66				all cancers(107;0.0137)		CGTCTCAGAGCTTGTGACGAT	0.532000													5	58					8.12818e-05	9.08615e-05	0.248553	1	0
ZSCAN22	342945	broad.mit.edu	37	19	58850395	58850395	+	Silent	SNP	G	G	A			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr19:58850395G>A	ENST00000329665.4	+	3	1326	c.1179G>A	c.(1177-1179)acG>acA	p.T393T		NM_181846.2	NP_862829.1	P10073	ZSC22_HUMAN	zinc finger and SCAN domain containing 22	393					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			cervix(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(7)|pancreas(1)|prostate(2)	16		all_cancers(17;3.11e-12)|all_epithelial(17;9.43e-09)|Colorectal(82;0.000256)|Lung NSC(17;0.000607)|all_lung(17;0.0024)|all_neural(62;0.0412)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0289)		GCCAGAGCACGCACCTGACTC	0.647000													9	62					0	0	0.411799	0	0
SAP130	79595	broad.mit.edu	37	2	128699639	128699639	+	Missense_Mutation	SNP	G	G	T			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr2:128699639G>T	ENST00000357702.5	-	21	3324	c.3193C>A	c.(3193-3195)Ctt>Att	p.L1065I	SAP130_ENST00000259234.6_Missense_Mutation_p.L1038I|SAP130_ENST00000259235.3_Missense_Mutation_p.L1030I	NM_001145928.1	NP_001139400.1	Q9H0E3	SP130_HUMAN	Sin3A-associated protein, 130kDa	1030					histone H3 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	STAGA complex	transcription coactivator activity			NS(4)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(11)|lung(10)|ovary(2)|prostate(1)|skin(5)|urinary_tract(2)	45	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0771)		TTCTTGTTAAGCAGCTTCAGG	0.403000													6	80					0.217242	0.220054	0.217242	1	0
CPEB4	80315	broad.mit.edu	37	5	173380139	173380139	+	Missense_Mutation	SNP	A	A	G			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr5:173380139A>G	ENST00000265085.5	+	9	3280	c.1826A>G	c.(1825-1827)tAc>tGc	p.Y609C	CPEB4_ENST00000334035.5_Missense_Mutation_p.Y592C|CPEB4_ENST00000520867.1_Missense_Mutation_p.Y584C|CPEB4_ENST00000519467.1_3'UTR|CPEB4_ENST00000519835.1_Missense_Mutation_p.Y584C|CPEB4_ENST00000517880.1_Missense_Mutation_p.Y202C|CPEB4_ENST00000522336.1_Missense_Mutation_p.Y219C	NM_030627.2	NP_085130.2	Q17RY0	CPEB4_HUMAN	cytoplasmic polyadenylation element binding protein 4	609	RRM 2.						nucleotide binding|RNA binding			NS(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(5)|prostate(1)|stomach(1)|upper_aerodigestive_tract(2)	20	Renal(175;0.000159)|Lung NSC(126;0.0128)|all_lung(126;0.0202)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000183)			GGTGTGTGCTACGCTGGGATT	0.448000													25	152					0	0	0.750413	0	0
ME2	4200	broad.mit.edu	37	18	48434439	48434439	+	Missense_Mutation	SNP	G	G	T			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr18:48434439G>T	ENST00000321341.5	+	3	387	c.115G>T	c.(115-117)Gca>Tca	p.A39S	ME2_ENST00000382927.3_Missense_Mutation_p.A39S	NM_002396.4	NP_002387.1	P23368	MAOM_HUMAN	malic enzyme 2, NAD(+)-dependent, mitochondrial	39					malate metabolic process	mitochondrial matrix	electron carrier activity|malate dehydrogenase (decarboxylating) activity|malate dehydrogenase (oxaloacetate-decarboxylating) activity|metal ion binding|NAD binding			breast(2)|endometrium(1)|kidney(2)|large_intestine(4)|lung(11)|upper_aerodigestive_tract(3)	23		Colorectal(6;0.0273)|all_epithelial(6;0.118)		Colorectal(21;0.0313)|READ - Rectum adenocarcinoma(32;0.105)|STAD - Stomach adenocarcinoma(97;0.184)	NADH(DB00157)	TTAGGGAATGGCATTTACTTT	0.313000													4	29					0.00909568	0.00971655	0.150653	1	0
RNF148	378925	broad.mit.edu	37	7	122342626	122342626	+	Missense_Mutation	SNP	C	C	A			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr7:122342626C>A	ENST00000434824.1	-	1	395	c.179G>T	c.(178-180)gGa>gTa	p.G60V	CADPS2_ENST00000313070.7_Intron|CADPS2_ENST00000449022.2_Intron|CADPS2_ENST00000412584.2_Intron|RNF148_ENST00000447240.1_Intron|CADPS2_ENST00000334010.7_Intron	NM_198085.1	NP_932351.1	Q8N7C7	RN148_HUMAN	ring finger protein 148	60						integral to membrane	zinc ion binding			endometrium(2)|kidney(1)|large_intestine(6)|lung(7)	16						CCCGAACACTCCACTCTCTCC	0.458000													18	48					5.45024e-15	7.25926e-15	0.654019	1	0
GDNF	2668	broad.mit.edu	37	5	37816214	37816214	+	Missense_Mutation	SNP	C	C	A			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr5:37816214C>A	ENST00000326524.2	-	3	374	c.175G>T	c.(175-177)Gat>Tat	p.D59Y	GDNF_ENST00000381826.4_Missense_Mutation_p.D50Y|GDNF_ENST00000515058.1_Missense_Mutation_p.D33Y|GDNF_ENST00000427982.1_Missense_Mutation_p.D76Y|GDNF_ENST00000344622.4_Missense_Mutation_p.D33Y	NM_000514.3	NP_000505.1	P39905	GDNF_HUMAN	glial cell derived neurotrophic factor	59					adult locomotory behavior|anti-apoptosis|axon guidance|branching involved in ureteric bud morphogenesis|enteric nervous system development|mRNA stabilization|negative regulation of neuron apoptosis|neural crest cell migration|peristalsis|positive regulation of branching involved in ureteric bud morphogenesis|positive regulation of dopamine secretion|positive regulation of monooxygenase activity|positive regulation of transcription from RNA polymerase II promoter|positive regulation of ureteric bud formation|postganglionic parasympathetic nervous system development|regulation of dopamine uptake|signal transduction|sympathetic nervous system development	extracellular region	growth factor activity|protein homodimerization activity			NS(1)|endometrium(1)|large_intestine(2)|liver(1)|lung(8)|skin(2)	15	all_lung(31;0.00118)					TCGAACTGATCAGGATAATCC	0.398000													4	61					1.23904e-05	1.42058e-05	0.184627	1	0
MUC17	140453	broad.mit.edu	37	7	100679759	100679759	+	Missense_Mutation	SNP	G	G	A			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr7:100679759G>A	ENST00000306151.4	+	3	5126	c.5062G>A	c.(5062-5064)Gga>Aga	p.G1688R		NM_001040105.1	NP_001035194.1	Q685J3	MUC17_HUMAN	mucin 17, cell surface associated	1688	59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			NS(3)|breast(14)|central_nervous_system(2)|cervix(2)|endometrium(27)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(28)|lung(179)|ovary(19)|pancreas(1)|prostate(13)|skin(26)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	343	Lung NSC(181;0.136)|all_lung(186;0.182)					TTATACTGAAGGAAGAACTCC	0.473000													27	185					0	0	0.740014	0	0
ADCY8	114	broad.mit.edu	37	8	131922058	131922058	+	Silent	SNP	G	G	A	rs150100724		TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr8:131922058G>A	ENST00000286355.5	-	6	3628	c.1536C>T	c.(1534-1536)tcC>tcT	p.S512S	ADCY8_ENST00000377928.3_Silent_p.S512S	NM_001115.2	NP_001106.1	P40145	ADCY8_HUMAN	adenylate cyclase 8 (brain)	512					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|membrane fraction|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|metal ion binding			NS(1)|breast(4)|central_nervous_system(2)|cervix(1)|endometrium(10)|kidney(5)|large_intestine(21)|lung(67)|pancreas(1)|prostate(3)|skin(12)|upper_aerodigestive_tract(5)|urinary_tract(2)	134	Esophageal squamous(12;0.00693)|Ovarian(258;0.00707)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000538)			GCACCGAGCCGGAGTGGATTC	0.473000										HNSCC(32;0.087)			16	111					0	0	0.557998	0	0
ATF5	22809	broad.mit.edu	37	19	50435876	50435876	+	Missense_Mutation	SNP	T	T	C			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr19:50435876T>C	ENST00000423777.2	+	3	753	c.376T>C	c.(376-378)Tcc>Ccc	p.S126P	ATF5_ENST00000595125.1_Missense_Mutation_p.S126P|CTC-326K19.6_ENST00000451973.1_Intron	NM_001193646.1	NP_001180575.1	Q9Y2D1	ATF5_HUMAN	activating transcription factor 5	126	Interaction with PTP4A1 (By similarity).|Poly-Pro.				regulation of transcription from RNA polymerase II promoter	cytoplasm	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity	p.S126P(1)		NS(1)|endometrium(2)|large_intestine(1)|skin(3)	7		all_lung(116;0.00318)|all_neural(266;0.107)|Ovarian(192;0.17)		GBM - Glioblastoma multiforme(134;0.00221)|OV - Ovarian serous cystadenocarcinoma(262;0.017)		Cccaccaccctccccgccgcc	0.642000													5	7					0	0	0.217242	0	0
EHBP1L1	254102	broad.mit.edu	37	11	65349331	65349331	+	Silent	SNP	A	A	G			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr11:65349331A>G	ENST00000309295.4	+	9	1453	c.1188A>G	c.(1186-1188)ccA>ccG	p.P396P		NM_001099409.1	NP_001092879.1	Q8N3D4	EH1L1_HUMAN	EH domain binding protein 1-like 1	396										central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(3)|lung(6)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	23						ACACTGAGCCAAGGTCAGGAG	0.547000													6	26					0	0	0.278610	0	0
KCNT2	343450	broad.mit.edu	37	1	196227558	196227558	+	Missense_Mutation	SNP	G	G	T			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr1:196227558G>T	ENST00000367433.5	-	25	3006	c.2905C>A	c.(2905-2907)Cgc>Agc	p.R969S	KCNT2_ENST00000367431.4_Missense_Mutation_p.R927S|KCNT2_ENST00000498426.1_5'UTR|KCNT2_ENST00000294725.8_Missense_Mutation_p.R993S|KCNT2_ENST00000451324.2_3'UTR			Q6UVM3	KCNT2_HUMAN	potassium channel, subfamily T, member 2	993						voltage-gated potassium channel complex	ATP binding|calcium-activated potassium channel activity|voltage-gated potassium channel activity			NS(1)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(16)|lung(43)|ovary(5)|pancreas(1)|prostate(1)|skin(11)|stomach(2)|upper_aerodigestive_tract(1)	97						TGGTTGCTGCGGTGGTGCCCT	0.468000													52	103					4.13886e-29	5.88847e-29	0.870114	1	0
AWAT1	158833	broad.mit.edu	37	X	69459684	69459684	+	Missense_Mutation	SNP	C	C	A			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chrX:69459684C>A	ENST00000374521.3	+	6	773	c.732C>A	c.(730-732)ttC>ttA	p.F244L		NM_001013579.2	NP_001013597.1	Q58HT5	AWAT1_HUMAN	acyl-CoA wax alcohol acyltransferase 1	244					lipid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	long-chain-alcohol O-fatty-acyltransferase activity			breast(2)|central_nervous_system(1)|large_intestine(4)|lung(3)|ovary(4)|skin(1)	15						AGAGCTGCTTCCGCCGTATCT	0.507000													16	83					6.94344e-10	8.79878e-10	0.539581	1	0
MYH11	4629	broad.mit.edu	37	16	15832534	15832534	+	Silent	SNP	G	G	T			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr16:15832534G>T	ENST00000338282.6	-	24	3115	c.3009C>A	c.(3007-3009)ctC>ctA	p.L1003L	MYH11_ENST00000576790.1_Silent_p.L1003L|MYH11_ENST00000452625.2_Silent_p.L1010L|MYH11_ENST00000300036.5_Silent_p.L1003L|MYH11_ENST00000396324.3_Silent_p.L1010L	NM_022844.2	NP_074035.1	P35749	MYH11_HUMAN	myosin, heavy chain 11, smooth muscle	1003					axon guidance|cardiac muscle fiber development|elastic fiber assembly|skeletal muscle myosin thick filament assembly|smooth muscle contraction	cytosol|melanosome|muscle myosin complex|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			NS(2)|breast(7)|central_nervous_system(1)|endometrium(11)|kidney(5)|large_intestine(34)|liver(1)|lung(37)|ovary(9)|pancreas(1)|prostate(7)|skin(7)|upper_aerodigestive_tract(1)	123						TCTCCTCAAGGAGTTTTCGTT	0.353000			T	CBFB	AML								7	53					1.12685e-05	1.31606e-05	0.307466	1	0
UTS2B	257313	broad.mit.edu	37	3	190993123	190993123	+	Silent	SNP	T	T	C			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr3:190993123T>C	ENST00000340524.5	-	8	1038	c.252A>G	c.(250-252)ctA>ctG	p.L84L	UTS2B_ENST00000427544.2_Silent_p.L84L	NM_198152.3	NP_937795.2			urotensin 2B																		GCTGTTCTTTTAGCTTTTCCA	0.418000													15	65					0	0	0.500413	0	0
FAT2	2196	broad.mit.edu	37	5	150947878	150947878	+	Silent	SNP	C	C	T			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr5:150947878C>T	ENST00000261800.5	-	1	627	c.615G>A	c.(613-615)gtG>gtA	p.V205V		NM_001447.2	NP_001438.1	Q9NYQ8	FAT2_HUMAN	FAT atypical cadherin 2	205	Cadherin 2.				epithelial cell migration|homophilic cell adhesion	cell-cell adherens junction|integral to membrane|nucleus	calcium ion binding			NS(6)|breast(3)|central_nervous_system(3)|cervix(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(61)|liver(1)|lung(60)|ovary(6)|prostate(5)|skin(5)|stomach(2)|upper_aerodigestive_tract(11)|urinary_tract(1)	196		Medulloblastoma(196;0.0912)|all_hematologic(541;0.104)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			GCTTCCCAGCCACAGTGACCA	0.537000													6	59					0	0	0.248553	0	0
ERCC4	2072	broad.mit.edu	37	16	14041714	14041714	+	Missense_Mutation	SNP	G	G	T	rs143357336	byFrequency	TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr16:14041714G>T	ENST00000311895.7	+	11	2270	c.2261G>T	c.(2260-2262)cGt>cTt	p.R754L		NM_005236.2	NP_005227.1	Q92889	XPF_HUMAN	excision repair cross-complementing rodent repair deficiency, complementation group 4	754	ERCC4.|Interaction with EME1 and ERCC1.				double-strand break repair via homologous recombination|meiotic mismatch repair|negative regulation of telomere maintenance|nucleotide-excision repair, DNA damage removal|nucleotide-excision repair, DNA incision, 3'-to lesion|nucleotide-excision repair, DNA incision, 5'-to lesion|resolution of meiotic recombination intermediates|telomere maintenance via telomere shortening|transcription-coupled nucleotide-excision repair	nuclear chromosome, telomeric region|nucleoplasm|nucleotide-excision repair factor 1 complex	damaged DNA binding|protein C-terminus binding|protein N-terminus binding|single-stranded DNA binding|single-stranded DNA specific endodeoxyribonuclease activity			NS(1)|breast(1)|endometrium(7)|kidney(3)|large_intestine(5)|lung(12)|ovary(4)|pancreas(1)|prostate(1)|skin(3)	38						TACTACAAGCGTCCCGTGCTT	0.493000			"""Mis, N, F"""			"""skin basal cell, skin squamous cell, melanoma"""		Nucleotide excision repair (NER)	Xeroderma Pigmentosum				6	83					2.52707e-12	3.28204e-12	0.335167	1	0
SLC9A7	84679	broad.mit.edu	37	X	46618270	46618270	+	Missense_Mutation	SNP	C	C	G			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chrX:46618270C>G	ENST00000328306.4	-	1	220	c.195G>C	c.(193-195)gaG>gaC	p.E65D		NM_001257291.1|NM_032591.2	NP_001244220.1|NP_115980.1	Q96T83	SL9A7_HUMAN	solute carrier family 9, subfamily A (NHE7, cation proton antiporter 7), member 7	65					regulation of pH	Golgi membrane|integral to membrane|recycling endosome membrane|trans-Golgi network	potassium:hydrogen antiporter activity|protein homodimerization activity|sodium:hydrogen antiporter activity			breast(2)|cervix(2)|endometrium(3)|kidney(1)|large_intestine(6)|lung(3)|ovary(2)|prostate(1)|skin(1)	21						GCCGGTGGCTCTCCTCCGCCT	0.682000													68	29					0	0	0.870114	0	0
OR10S1	219873	broad.mit.edu	37	11	123847690	123847690	+	Missense_Mutation	SNP	C	C	A			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr11:123847690C>A	ENST00000531945.1	-	1	798	c.709G>T	c.(709-711)Gca>Tca	p.A237S		NM_001004474.1	NP_001004474.1	Q8NGN2	O10S1_HUMAN	olfactory receptor, family 10, subfamily S, member 1	237					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(16)|ovary(1)|prostate(2)|skin(2)|urinary_tract(1)	36		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0399)		AACACAGCTGCCACGATGAAG	0.587000													11	49					1.3612e-06	1.65138e-06	0.479597	1	0
GRIA3	2892	broad.mit.edu	37	X	122532604	122532604	+	Missense_Mutation	SNP	C	C	A			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chrX:122532604C>A	ENST00000264357.5	+	7	1322	c.1030C>A	c.(1030-1032)Cct>Act	p.P344T	GRIA3_ENST00000541091.1_Missense_Mutation_p.P328T|GRIA3_ENST00000371251.1_Missense_Mutation_p.P344T|GRIA3_ENST00000371256.5_Missense_Mutation_p.P344T|GRIA3_ENST00000542149.1_Missense_Mutation_p.P344T	NM_000828.4	NP_000819.3	P42263	GRIA3_HUMAN	glutamate receptor, ionotropic, AMPA 3	344					glutamate signaling pathway|synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|endocytic vesicle membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity			breast(2)|central_nervous_system(1)|endometrium(8)|kidney(3)|large_intestine(8)|lung(25)|ovary(3)|pancreas(2)|skin(2)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(1)	57					L-Glutamic Acid(DB00142)	CTTAGCAAATCCTGCTGTGCC	0.473000													8	45					1.58986e-06	1.92134e-06	0.361761	1	0
PCDH11X	27328	broad.mit.edu	37	X	91133302	91133302	+	Missense_Mutation	SNP	C	C	A			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chrX:91133302C>A	ENST00000373094.1	+	2	2908	c.2063C>A	c.(2062-2064)tCc>tAc	p.S688Y	PCDH11X_ENST00000395337.2_Missense_Mutation_p.S688Y|PCDH11X_ENST00000373097.1_Missense_Mutation_p.S688Y|PCDH11X_ENST00000373088.1_Missense_Mutation_p.S688Y|PCDH11X_ENST00000504220.1_Missense_Mutation_p.S688Y|PCDH11X_ENST00000361724.1_Missense_Mutation_p.S688Y|PCDH11X_ENST00000361655.2_Missense_Mutation_p.S688Y|PCDH11X_ENST00000298274.8_Missense_Mutation_p.S688Y|PCDH11X_ENST00000406881.1_Missense_Mutation_p.S688Y	NM_032968.3	NP_116750.1	Q9BZA7	PC11X_HUMAN	protocadherin 11 X-linked	688	Cadherin 7.				homophilic cell adhesion	integral to plasma membrane	calcium ion binding			NS(1)|autonomic_ganglia(1)|biliary_tract(1)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(30)|liver(4)|lung(92)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	159						GTTCTACCGTCCACTAATCCA	0.423000													8	150					4.36969e-10	5.5825e-10	0.435327	1	0
GUCY1A2	2977	broad.mit.edu	37	11	106681009	106681009	+	Silent	SNP	T	T	G			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr11:106681009T>G	ENST00000526355.1	-	5	1870	c.1402A>C	c.(1402-1404)Agg>Cgg	p.R468R	GUCY1A2_ENST00000347596.2_Silent_p.R489R|GUCY1A2_ENST00000282249.2_Silent_p.R468R	NM_000855.2	NP_000846.1	P33402	GCYA2_HUMAN	guanylate cyclase 1, soluble, alpha 2	468					intracellular signal transduction|platelet activation	cytoplasm	GTP binding|guanylate cyclase activity|heme binding			breast(5)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(18)|liver(1)|lung(32)|ovary(1)|pancreas(2)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	74		all_epithelial(67;3.66e-05)|Melanoma(852;0.000382)|Acute lymphoblastic leukemia(157;0.001)|all_hematologic(158;0.0017)|Breast(348;0.026)|all_neural(303;0.068)		BRCA - Breast invasive adenocarcinoma(274;8.04e-05)|Epithelial(105;0.0036)|all cancers(92;0.0476)		TTATCCATCCTTTTCTTCAAC	0.458000													4	55					0	0	0.217242	0	0
GPM6A	2823	broad.mit.edu	37	4	176622830	176622830	+	Silent	SNP	C	C	A			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr4:176622830C>A	ENST00000280187.7	-	3	171	c.126G>T	c.(124-126)ctG>ctT	p.L42L	GPM6A_ENST00000515090.1_Silent_p.L35L|GPM6A_ENST00000506894.1_Silent_p.L31L|GPM6A_ENST00000393658.2_Silent_p.L42L	NM_005277.4	NP_005268.1	P51674	GPM6A_HUMAN	glycoprotein M6A	42						cell surface|integral to membrane				NS(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(16)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	33		Breast(14;7.35e-05)|Melanoma(52;0.00909)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;9.21e-19)|Epithelial(43;3.01e-17)|OV - Ovarian serous cystadenocarcinoma(60;2.02e-09)|STAD - Stomach adenocarcinoma(60;0.00083)|GBM - Glioblastoma multiforme(59;0.00168)|LUSC - Lung squamous cell carcinoma(193;0.0388)		AGCCACAGAACAGGGCAACAC	0.493000													15	157					5.35267e-07	6.51901e-07	0.557998	1	0
PTF1A	256297	broad.mit.edu	37	10	23482775	23482775	+	Silent	SNP	C	C	G			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr10:23482775C>G	ENST00000376504.3	+	2	1131	c.927C>G	c.(925-927)ctC>ctG	p.L309L		NM_178161.2	NP_835455.1	Q7RTS3	PTF1A_HUMAN	pancreas specific transcription factor, 1a	309					endocrine pancreas development|exocrine pancreas development|regulation of transcription, DNA-dependent|tissue development|transcription, DNA-dependent	cytoplasm|transcription factor complex				endometrium(1)|large_intestine(1)|lung(3)|pancreas(1)|skin(1)	7						CCAGAAAACTCAACAGCAAAT	0.438000													9	113					0	0	0.335167	0	0
KRTAP4-7	100132476	broad.mit.edu	37	17	39240908	39240908	+	Silent	SNP	T	T	C			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr17:39240908T>C	ENST00000391417.4	+	1	450	c.450T>C	c.(448-450)tgT>tgC	p.C150C		NM_033061.3	NP_149050.3			keratin associated protein 4-7									p.C150C(1)		NS(1)|endometrium(3)|kidney(1)|lung(1)|prostate(2)|urinary_tract(1)	9						CCTTGTGCTGTGCCTCCTCTT	0.607000													4	14					0	0	0.278610	0	0
UNC79	57578	broad.mit.edu	37	14	94107579	94107579	+	Silent	SNP	G	G	T			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr14:94107579G>T	ENST00000553484.1	+	35	6226	c.6072G>T	c.(6070-6072)acG>acT	p.T2024T	UNC79_ENST00000256339.4_Silent_p.T1825T|UNC79_ENST00000555664.1_Silent_p.T1963T|UNC79_ENST00000393151.2_Silent_p.T2002T			Q9P2D8	UNC79_HUMAN	unc-79 homolog (C. elegans)	2002						integral to membrane				breast(3)|cervix(2)|endometrium(10)|kidney(7)|large_intestine(18)|liver(1)|lung(64)|ovary(1)|prostate(5)|skin(3)|urinary_tract(4)	118						AGCAGCCGACGGTGATGACGG	0.463000													5	23					0.0215528	0.0226376	0.217242	1	0
HAO1	54363	broad.mit.edu	37	20	7886899	7886899	+	Missense_Mutation	SNP	T	T	A			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr20:7886899T>A	ENST00000378789.3	-	4	674	c.623A>T	c.(622-624)tAt>tTt	p.Y208F		NM_017545.2	NP_060015.1	Q9UJM8	HAOX1_HUMAN	hydroxyacid oxidase (glycolate oxidase) 1	208	FMN hydroxy acid dehydrogenase.				cellular nitrogen compound metabolic process|fatty acid alpha-oxidation|glycolate catabolic process|glyoxylate metabolic process	peroxisomal matrix	FMN binding|glycolate oxidase activity|glyoxylate oxidase activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(19)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	36						TTTAGCCACATATGCAGCAAG	0.373000													29	63					0	0	0.769981	0	0
GPR123	84435	broad.mit.edu	37	10	134884542	134884542	+	Missense_Mutation	SNP	G	G	A			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr10:134884542G>A	ENST00000607359.1	+	1	110	c.110G>A	c.(109-111)cGg>cAg	p.R37Q				Q86SQ6	GP123_HUMAN	G protein-coupled receptor 123	0						integral to membrane|plasma membrane	G-protein coupled receptor activity			endometrium(2)|kidney(2)|large_intestine(1)|lung(6)|prostate(3)	14		all_cancers(35;1.8e-10)|all_epithelial(44;8.95e-09)|Lung NSC(174;0.000845)|all_lung(145;0.00144)|all_neural(114;0.0299)|Colorectal(31;0.0585)|Melanoma(40;0.123)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;9.16e-06)|Epithelial(32;1.21e-05)|all cancers(32;1.63e-05)		CGAGGGGGCCGGACACCACAG	0.657000													7	23					0	0	0.387290	0	0
MAML2	84441	broad.mit.edu	37	11	95825485	95825485	+	Missense_Mutation	SNP	C	C	G			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr11:95825485C>G	ENST00000524717.1	-	2	2994	c.1710G>C	c.(1708-1710)caG>caC	p.Q570H		NM_032427.1	NP_115803.1	Q8IZL2	MAML2_HUMAN	mastermind-like 2 (Drosophila)	570					Notch signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear speck	transcription coactivator activity		CRTC3/MAML2(26)|CRTC1/MAML2(516)	breast(2)|cervix(1)|endometrium(11)|kidney(4)|large_intestine(8)|lung(12)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	43		Acute lymphoblastic leukemia(157;2.63e-05)|all_hematologic(158;0.00837)				CAGAAGGCATCTGCTGGTTCG	0.522000			T	"""MECT1, CRTC3"""	salivary gland mucoepidermoid								2	5					0	0	0.115264	0	0
CFHR5	81494	broad.mit.edu	37	1	196977760	196977760	+	Missense_Mutation	SNP	C	C	A			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr1:196977760C>A	ENST00000367414.5	+	10	1785	c.1729C>A	c.(1729-1731)Cca>Aca	p.P577T	CFHR5_ENST00000256785.4_Missense_Mutation_p.P553T	NM_030787.3	NP_110414.1	Q9BXR6	FHR5_HUMAN	complement factor H-related 5	553					complement activation, alternative pathway	extracellular region				NS(2)|breast(2)|endometrium(2)|kidney(1)|large_intestine(7)|liver(2)|lung(23)|pancreas(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)	49						ATCATCACCACCATTTCGAGC	0.363000													23	79					6.00712e-18	8.24662e-18	0.760397	1	0
PLCE1	51196	broad.mit.edu	37	10	96033397	96033397	+	Missense_Mutation	SNP	G	G	T			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr10:96033397G>T	ENST00000260766.3	+	19	5219	c.4585G>T	c.(4585-4587)Gac>Tac	p.D1529Y	PLCE1_ENST00000371385.3_Missense_Mutation_p.D1221Y|PLCE1_ENST00000371375.1_Missense_Mutation_p.D1221Y|PLCE1_ENST00000371380.2_Missense_Mutation_p.D1529Y	NM_016341.3	NP_057425.3	Q9P212	PLCE1_HUMAN	phospholipase C, epsilon 1	1529	PI-PLC X-box.				activation of MAPK activity|activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|calcium-mediated signaling|cell proliferation|cytoskeleton organization|diacylglycerol biosynthetic process|elevation of cytosolic calcium ion concentration|epidermal growth factor receptor signaling pathway|glomerulus development|heart development|lipid catabolic process|Ras protein signal transduction|regulation of cell growth|regulation of G-protein coupled receptor protein signaling pathway|regulation of Ras protein signal transduction|regulation of smooth muscle contraction	cytosol|Golgi membrane|membrane fraction|plasma membrane	calcium ion binding|guanyl-nucleotide exchange factor activity|phosphatidylinositol phospholipase C activity|Ras GTPase binding|receptor signaling protein activity			liver(1)|ovary(2)|skin(4)|upper_aerodigestive_tract(1)	8		Colorectal(252;0.0458)				TCCTTCACCTGACCAACTCAG	0.383000													6	41					0.0215528	0.0226376	0.217242	1	0
CNKSR2	22866	broad.mit.edu	37	X	21670456	21670456	+	Missense_Mutation	SNP	A	A	C			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chrX:21670456A>C	ENST00000425654.2	+	21	3312	c.2832A>C	c.(2830-2832)aaA>aaC	p.K944N	CNKSR2_ENST00000379510.3_Missense_Mutation_p.K974N	NM_001168647.1	NP_001162118.1	Q8WXI2	CNKR2_HUMAN	connector enhancer of kinase suppressor of Ras 2	974					regulation of signal transduction	cytoplasm|membrane	protein binding			breast(3)|endometrium(8)|kidney(2)|large_intestine(15)|lung(28)|prostate(2)|upper_aerodigestive_tract(3)	61						TTATCGATAAAGTCCTAGACA	0.358000													4	66					0	0	0.217242	0	0
C10orf95	79946	broad.mit.edu	37	10	104210870	104210870	+	Missense_Mutation	SNP	T	T	A			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr10:104210870T>A	ENST00000239125.1	-	2	192	c.118A>T	c.(118-120)Agc>Tgc	p.S40C	RP11-18I14.10_ENST00000473970.2_RNA|RP11-18I14.10_ENST00000492465.2_RNA|RP11-18I14.10_ENST00000594818.1_RNA|RP11-18I14.10_ENST00000494270.2_RNA|RP11-18I14.10_ENST00000596366.1_RNA|RP11-18I14.10_ENST00000596045.1_RNA	NM_024886.1	NP_079162.1	Q9H7T3	CJ095_HUMAN	chromosome 10 open reading frame 95	40										liver(1)	1		Colorectal(252;0.207)		Epithelial(162;8.34e-09)|all cancers(201;1.95e-07)|BRCA - Breast invasive adenocarcinoma(275;0.213)		CCCAGGCGGCTGCTGTTCTTA	0.662000													3	19					0	0	0.184627	0	0
PTPRO	5800	broad.mit.edu	37	12	15742395	15742395	+	Silent	SNP	C	C	A			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr12:15742395C>A	ENST00000281171.4	+	25	3747	c.3417C>A	c.(3415-3417)ggC>ggA	p.G1139G	PTPRO_ENST00000445537.2_Silent_p.G328G|PTPRO_ENST00000442921.2_Silent_p.G328G|PTPRO_ENST00000348962.2_Silent_p.G1111G|PTPRO_ENST00000542557.1_Silent_p.G300G|PTPRO_ENST00000544244.1_Silent_p.G300G	NM_030667.2	NP_109592.1	Q16827	PTPRO_HUMAN	protein tyrosine phosphatase, receptor type, O	1139	Substrate binding (By similarity).|Tyrosine-protein phosphatase.					integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(2)|central_nervous_system(1)|endometrium(7)|kidney(2)|large_intestine(11)|lung(30)|ovary(2)|prostate(1)|skin(17)|upper_aerodigestive_tract(1)	74		Hepatocellular(102;0.244)				GCAGTGCTGGCGTGGGACGGA	0.453000													37	115					1.61863e-15	2.17438e-15	0.870114	1	0
DRD3	1814	broad.mit.edu	37	3	113850099	113850099	+	Missense_Mutation	SNP	G	G	A			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr3:113850099G>A	ENST00000383673.2	-	6	1302	c.872C>T	c.(871-873)gCg>gTg	p.A291V	DRD3_ENST00000295881.7_Intron|DRD3_ENST00000460779.1_Missense_Mutation_p.A291V|DRD3_ENST00000467632.1_Missense_Mutation_p.A291V	NM_000796.3	NP_000787.2	P35462	DRD3_HUMAN	dopamine receptor D3	291					activation of adenylate cyclase activity by dopamine receptor signaling pathway|arachidonic acid secretion|behavioral response to cocaine|cellular calcium ion homeostasis|circadian regulation of gene expression|G-protein coupled receptor internalization|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|locomotory behavior|musculoskeletal movement, spinal reflex action|negative regulation of blood pressure|negative regulation of oligodendrocyte differentiation|negative regulation of protein kinase B signaling cascade|negative regulation of protein secretion|positive regulation of dopamine receptor signaling pathway|positive regulation of mitosis|prepulse inhibition|regulation of dopamine secretion|response to drug|response to histamine|response to morphine|social behavior|visual learning	integral to plasma membrane	dopamine D3 receptor activity|drug binding			central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(4)|liver(1)|lung(23)|ovary(1)|pancreas(1)|skin(1)	36					Apomorphine(DB00714)|Chlorprothixene(DB01239)|Cocaine(DB00907)|Methotrimeprazine(DB01403)|Olanzapine(DB00334)|Pramipexole(DB00413)|Ropinirole(DB00268)|Ziprasidone(DB00246)	GAGCTTGGGCGCTATGGTGGG	0.542000													24	135					0	0	0.706142	0	0
C2orf70	339778	broad.mit.edu	37	2	26799015	26799015	+	Missense_Mutation	SNP	G	G	T			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr2:26799015G>T	ENST00000329615.3	+	2	351	c.320G>T	c.(319-321)cGc>cTc	p.R107L	C2orf70_ENST00000409392.1_Silent_p.S94S	NM_001105519.1	NP_001098989.1	A6NJV1	CB070_HUMAN	chromosome 2 open reading frame 70	107										breast(3)|endometrium(2)|large_intestine(1)|lung(4)|prostate(1)|skin(2)	13						GACAGCCATCGCTCCACAGAG	0.637000													13	88					0.000219431	0.00024442	0.457914	1	0
C2orf16	84226	broad.mit.edu	37	2	27804634	27804634	+	Missense_Mutation	SNP	G	G	A			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr2:27804634G>A	ENST00000408964.2	+	1	5246	c.5195G>A	c.(5194-5196)aGa>aAa	p.R1732K		NM_032266.3	NP_115642.3	Q68DN1	CB016_HUMAN	chromosome 2 open reading frame 16	1732	27 X 8 AA approximative tandem repeat of P-S-E-R-S-H-H-S.|Arg-rich.									breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(33)|urinary_tract(1)	47	Acute lymphoblastic leukemia(172;0.155)					CCCTCAGAGAGAAGCCATCAC	0.562000													6	239					0	0	0.217242	0	0
SLC37A3	84255	broad.mit.edu	37	7	140037109	140037109	+	Nonsense_Mutation	SNP	C	C	T			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr7:140037109C>T	ENST00000326232.9	-	14	1570	c.1367G>A	c.(1366-1368)tGg>tAg	p.W456*	SLC37A3_ENST00000340308.3_Silent_p.V355V|SLC37A3_ENST00000447932.2_Nonsense_Mutation_p.W440*	NM_207113.1	NP_996996.1	Q8NCC5	SPX3_HUMAN	solute carrier family 37, member 3	456					carbohydrate transport|transmembrane transport	integral to membrane				endometrium(4)|kidney(1)|large_intestine(5)|lung(7)|ovary(3)|prostate(1)|stomach(3)	24	Melanoma(164;0.0142)					GTAGAAAACCCACATCCATCC	0.323000													3	31					0	0	0.150653	0	0
RACGAP1	29127	broad.mit.edu	37	12	50393004	50393004	+	Nonsense_Mutation	SNP	C	C	A			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr12:50393004C>A	ENST00000434422.1	-	10	1100	c.799G>T	c.(799-801)Gag>Tag	p.E267*	RACGAP1_ENST00000427314.2_Nonsense_Mutation_p.E267*|RACGAP1_ENST00000551016.1_Nonsense_Mutation_p.E267*|RACGAP1_ENST00000454520.2_Nonsense_Mutation_p.E267*|RACGAP1_ENST00000547905.1_Nonsense_Mutation_p.E267*|RACGAP1_ENST00000547061.1_5'UTR|RACGAP1_ENST00000312377.5_Nonsense_Mutation_p.E267*			Q9H0H5	RGAP1_HUMAN	Rac GTPase activating protein 1	267	Interaction with SLC26A8.				blood coagulation|cytokinesis, actomyosin contractile ring assembly|cytokinesis, initiation of separation|embryo development|microtubule-based movement|neuroblast proliferation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction|spermatogenesis|sulfate transport	acrosomal vesicle|cytosol|microtubule|midbody|nucleus|spindle	alpha-tubulin binding|beta-tubulin binding|gamma-tubulin binding|GTPase activator activity|metal ion binding			cervix(1)|endometrium(1)|kidney(3)|large_intestine(3)|lung(6)	14						GTTCTTGGCTCCAGCTGCCTG	0.453000													106	54					4.47202e-65	6.42084e-65	0.870114	1	0
BRWD3	254065	broad.mit.edu	37	X	79932311	79932311	+	Missense_Mutation	SNP	T	T	G	rs139074810		TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chrX:79932311T>G	ENST00000373275.4	-	41	5422	c.5206A>C	c.(5206-5208)Atg>Ctg	p.M1736L		NM_153252.4	NP_694984.4	Q6RI45	BRWD3_HUMAN	bromodomain and WD repeat domain containing 3	1736										breast(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|lung(39)|ovary(4)|prostate(2)|skin(3)	87						CCTGAAAACATGGTATCAAAT	0.438000													6	61					0	0	0.248553	0	0
ZNRF4	148066	broad.mit.edu	37	19	5456203	5456203	+	Missense_Mutation	SNP	C	C	T			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr19:5456203C>T	ENST00000222033.4	+	1	778	c.701C>T	c.(700-702)gCg>gTg	p.A234V		NM_181710.3	NP_859061.3	Q8WWF5	ZNRF4_HUMAN	zinc and ring finger 4	234						integral to membrane	zinc ion binding			NS(1)|kidney(2)|large_intestine(5)|lung(5)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	16				UCEC - Uterine corpus endometrioid carcinoma (162;0.0002)		TCGGCCCACGCGCTGCTCCTG	0.682000													12	58					0	0	0.411799	0	0
MMP2	4313	broad.mit.edu	37	16	55513493	55513493	+	Silent	SNP	C	C	T			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr16:55513493C>T	ENST00000219070.4	+	1	611	c.102C>T	c.(100-102)atC>atT	p.I34I	MMP2_ENST00000570308.1_Intron	NM_004530.4	NP_004521.1	P08253	MMP2_HUMAN	matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)	34					angiogenesis|collagen catabolic process|proteolysis	extracellular space|membrane|nucleus|proteinaceous extracellular matrix	metalloendopeptidase activity|protein binding|zinc ion binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(12)|liver(2)|lung(23)|ovary(3)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	58		Renal(780;0.00183)|Breast(268;0.00354)|Hepatocellular(780;0.00826)|all_neural(199;0.0189)		UCEC - Uterine corpus endometrioid carcinoma (183;0.0185)|all cancers(182;7.16e-45)|Epithelial(162;5.26e-37)|GBM - Glioblastoma multiforme(240;9e-08)|Kidney(780;0.00227)|BRCA - Breast invasive adenocarcinoma(181;0.00786)	Marimastat(DB00786)|Sulindac(DB00605)	CGTCGCCCATCATCAAGTTCC	0.657000													3	32					0	0	0.150653	0	0
SLC34A3	142680	broad.mit.edu	37	9	140126205	140126205	+	Silent	SNP	G	G	A			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr9:140126205G>A	ENST00000538474.1	+	2	275	c.51G>A	c.(49-51)gcG>gcA	p.A17A	SLC34A3_ENST00000361134.2_Silent_p.A17A	NM_001177316.1|NM_001177317.1	NP_001170787.1|NP_001170788.1	Q8N130	NPT2C_HUMAN	solute carrier family 34 (type II sodium/phosphate contransporter), member 3	17					cellular phosphate ion homeostasis	apical plasma membrane|integral to membrane	sodium-dependent phosphate transmembrane transporter activity|sodium:phosphate symporter activity			kidney(3)|lung(6)|ovary(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	13	all_cancers(76;0.0926)		STAD - Stomach adenocarcinoma(284;0.0698)	OV - Ovarian serous cystadenocarcinoma(145;6.37e-05)|Epithelial(140;0.00057)		CTCTGGACGCGGTTGACCTAG	0.647000													23	95					0	0	0.706142	0	0
NRXN3	9369	broad.mit.edu	37	14	79434666	79434666	+	Missense_Mutation	SNP	G	G	A			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr14:79434666G>A	ENST00000554719.1	+	11	2491	c.2000G>A	c.(1999-2001)gGa>gAa	p.G667E	NRXN3_ENST00000335750.5_Missense_Mutation_p.G667E	NM_004796.4	NP_004787.2	Q9HDB5	NRX3B_HUMAN	neurexin 3	0					angiogenesis|cell adhesion	integral to membrane				NS(1)|breast(4)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(23)|lung(40)|ovary(3)|pancreas(2)|prostate(5)|skin(7)|upper_aerodigestive_tract(9)|urinary_tract(1)	104		Renal(4;0.00876)		BRCA - Breast invasive adenocarcinoma(234;0.00544)|Kidney(3;0.029)|KIRC - Kidney renal clear cell carcinoma(182;0.223)		CATCGGAGCGGACAGATCGAG	0.522000													8	64					0	0	0.335167	0	0
RAPGEF2	9693	broad.mit.edu	37	4	160274840	160274840	+	Missense_Mutation	SNP	G	G	C			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr4:160274840G>C	ENST00000264431.4	+	22	4229	c.3810G>C	c.(3808-3810)gaG>gaC	p.E1270D		NM_014247.2	NP_055062.1	Q9Y4G8	RPGF2_HUMAN	Rap guanine nucleotide exchange factor (GEF) 2	1270					cAMP-mediated signaling|MAPKKK cascade|small GTPase mediated signal transduction	integral to plasma membrane|intracellular	calcium ion binding|diacylglycerol binding|Rap GTPase activator activity|Rap guanyl-nucleotide exchange factor activity|signal transducer activity			breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|liver(1)|lung(29)|ovary(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	70	all_hematologic(180;0.24)			COAD - Colon adenocarcinoma(41;0.0817)		GAAGCTGGGAGACTCTTCCAT	0.488000													10	99					0	0	0.411799	0	0
WBSCR17	64409	broad.mit.edu	37	7	70881005	70881005	+	Missense_Mutation	SNP	G	G	T			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr7:70881005G>T	ENST00000333538.5	+	4	1354	c.720G>T	c.(718-720)caG>caT	p.Q240H	WBSCR17_ENST00000498380.2_3'UTR	NM_022479.1	NP_071924.1	Q6IS24	GLTL3_HUMAN	Williams-Beuren syndrome chromosome region 17	240	Catalytic subdomain A.					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			NS(5)|breast(2)|central_nervous_system(1)|endometrium(7)|kidney(7)|large_intestine(22)|lung(45)|ovary(2)|pancreas(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)	100		all_cancers(73;0.2)|Lung NSC(55;0.094)|all_lung(88;0.125)				CTACCGGGCAGGTCACTGGCT	0.577000													6	76					0.00307968	0.00337042	0.278610	1	0
KCNB2	9312	broad.mit.edu	37	8	73480285	73480285	+	Missense_Mutation	SNP	G	G	T			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr8:73480285G>T	ENST00000523207.1	+	2	904	c.316G>T	c.(316-318)Ggg>Tgg	p.G106W		NM_004770.2	NP_004761.2	Q92953	KCNB2_HUMAN	potassium voltage-gated channel, Shab-related subfamily, member 2	106					regulation of smooth muscle contraction	voltage-gated potassium channel complex	delayed rectifier potassium channel activity|protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(20)|liver(2)|lung(31)|ovary(2)|pancreas(3)|prostate(2)|skin(8)|upper_aerodigestive_tract(4)|urinary_tract(1)	85	Breast(64;0.137)		Epithelial(68;0.105)			CTACCGGACCGGGAAACTCCA	0.468000													5	43					0.014758	0.0156585	0.184627	1	0
TSPYL2	64061	broad.mit.edu	37	X	53113784	53113784	+	Missense_Mutation	SNP	C	C	T			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chrX:53113784C>T	ENST00000375442.4	+	2	997	c.865C>T	c.(865-867)Cgc>Tgc	p.R289C		NM_022117.3	NP_071400.1	Q9H2G4	TSYL2_HUMAN	TSPY-like 2	289					cell cycle|chromatin modification|negative regulation of cell cycle|negative regulation of cell growth|negative regulation of DNA replication|nucleosome assembly|regulation of protein kinase activity|regulation of signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	protein binding|rDNA binding			central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(2)|lung(8)|upper_aerodigestive_tract(1)	19						AGACATTTTCCGCTACTTGAC	0.493000													17	181					0	0	0.592651	0	0
PRR16	51334	broad.mit.edu	37	5	120021977	120021977	+	Missense_Mutation	SNP	C	C	A			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr5:120021977C>A	ENST00000379551.2	+	3	776	c.419C>A	c.(418-420)cCt>cAt	p.P140H	PRR16_ENST00000505123.1_Missense_Mutation_p.P93H|PRR16_ENST00000407149.2_Missense_Mutation_p.P163H|PRR16_ENST00000446965.1_Missense_Mutation_p.P93H	NM_016644.1	NP_057728.1	Q569H4	PRR16_HUMAN	proline rich 16	163	Pro-rich.									endometrium(2)|kidney(2)|large_intestine(5)|lung(12)|ovary(1)|pancreas(2)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	28		all_cancers(142;0.0464)|Prostate(80;0.00446)	KIRC - Kidney renal clear cell carcinoma(527;0.159)|Kidney(363;0.221)	OV - Ovarian serous cystadenocarcinoma(64;0.000126)|Epithelial(69;0.000331)|all cancers(49;0.00169)		CCAGGTGGACCTAACAAAATT	0.463000													7	61					0.00448238	0.00487148	0.307466	1	0
TP53	7157	broad.mit.edu	37	17	7577538	7577538	+	Missense_Mutation	SNP	C	C	A	rs11540652		TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr17:7577538C>A	ENST00000420246.2	-	7	875	c.743G>T	c.(742-744)cGg>cTg	p.R248L	TP53_ENST00000413465.2_Missense_Mutation_p.R248L|TP53_ENST00000359597.4_Missense_Mutation_p.R248L|TP53_ENST00000455263.2_Missense_Mutation_p.R248L|TP53_ENST00000269305.4_Missense_Mutation_p.R248L|TP53_ENST00000445888.2_Missense_Mutation_p.R248L	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	248	Interaction with AXIN1 (By similarity).|Interaction with HIPK1 (By similarity).|Interacts with the 53BP2 SH3 domain.		NR -> IP (in a sporadic cancer; somatic mutation).|NR -> KW (in sporadic cancers; somatic mutation).|R -> C (in a sporadic cancer; somatic mutation).|R -> G (in sporadic cancers; somatic mutation).|R -> L (in sporadic cancers; somatic mutation).|R -> P (in sporadic cancers; somatic mutation).|R -> Q (in LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs11540652).|R -> W (in LFS; germline mutation and in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R248Q(580)|p.R248L(75)|p.R248P(19)|p.R155Q(18)|p.0?(8)|p.?(5)|p.R155L(3)|p.R155P(2)|p.N247_R248delNR(2)|p.R248fs*16(2)|p.M246_P250delMNRRP(2)|p.R248_P250delRRP(1)|p.unknown(1)|p.N247_R249delNRR(1)|p.N247_P250delNRRP(1)|p.R249fs*96(1)|p.R248fs*>39(1)|p.R248C(1)|p.G245fs*14(1)|p.N247_R248>IP(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GATGGGCCTCCGGTTCATGCC	0.572000	R248Q(BL41_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(CA46_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(CI1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(DB_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(EM2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(HCC1143_BREAST)|R248Q(HCC70_BREAST)|R248Q(HEC1A_ENDOMETRIUM)|R248Q(HS683_CENTRAL_NERVOUS_SYSTEM)|R248Q(HSC4_UPPER_AERODIGESTIVE_TRACT)|R248Q(KASUMI1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(KYO1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(KYSE150_OESOPHAGUS)|R248Q(MOLM6_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(NAMALWA_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(NB4_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(NCIH211_LUNG)|R248Q(NCIN87_STOMACH)|R248Q(NIHOVCAR3_OVARY)|R248Q(NUDHL1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(P12ICHIKAWA_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(PANC0203_PANCREAS)|R248Q(PC14_LUNG)|R248Q(PF382_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(RT112_URINARY_TRACT)|R248Q(SEM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(SF295_CENTRAL_NERVOUS_SYSTEM)|R248Q(SKUT1_SOFT_TISSUE)|R248Q(SUPT1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(SW1463_LARGE_INTESTINE)|R248Q(WSUDLCL2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)	111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			30	44					1.08052e-11	1.39178e-11	0.796494	1	0
THOC2	57187	broad.mit.edu	37	X	122747261	122747261	+	Missense_Mutation	SNP	C	C	A			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chrX:122747261C>A	ENST00000245838.8	-	36	4697	c.4666G>T	c.(4666-4668)Ggt>Tgt	p.G1556C	THOC2_ENST00000464992.1_5'UTR|THOC2_ENST00000491737.1_Missense_Mutation_p.G1441C|THOC2_ENST00000355725.4_Missense_Mutation_p.G1556C	NM_001081550.1	NP_001075019.1	Q8NI27	THOC2_HUMAN	THO complex 2	1556	Lys-rich.				intronless viral mRNA export from host nucleus|mRNA processing|RNA splicing	THO complex part of transcription export complex	protein binding|RNA binding			breast(2)|endometrium(13)|kidney(4)|large_intestine(11)|lung(26)|ovary(3)|skin(1)|upper_aerodigestive_tract(3)	63						TTTTTGCCACCGGAGGAGATT	0.294000													7	49					0.0477658	0.0498356	0.307466	1	0
CFH	3075	broad.mit.edu	37	1	196706028	196706028	+	Missense_Mutation	SNP	C	C	T	rs62641696	byFrequency	TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr1:196706028C>T	ENST00000367429.4	+	16	2728	c.2488C>T	c.(2488-2490)Cgg>Tgg	p.R830W		NM_000186.3	NP_000177.2	P08603	CFAH_HUMAN	complement factor H	830	Sushi 14.				complement activation, alternative pathway	extracellular space				NS(3)|breast(4)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(24)|lung(33)|ovary(1)|prostate(5)|skin(9)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	101						ACTGAATTATCGGGATGGAGA	0.343000													17	56					0	0	0.624587	0	0
IGHA2	3494	broad.mit.edu	37	14	106054582	106054582	+	RNA	SNP	T	T	C			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr14:106054582T>C	ENST00000390539.2	-	0	150																											GGGAAGTTTCTGGCGGTCACG	0.637000													12	68					0	0	0.435327	0	0
STAG1	10274	broad.mit.edu	37	3	136183774	136183774	+	Missense_Mutation	SNP	T	T	A			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr3:136183774T>A	ENST00000383202.2	-	13	1518	c.1262A>T	c.(1261-1263)tAc>tTc	p.Y421F	STAG1_ENST00000236698.5_Missense_Mutation_p.Y421F|STAG1_ENST00000536929.1_Intron|STAG1_ENST00000434713.2_Missense_Mutation_p.Y195F	NM_005862.2	NP_005853.2	Q8WVM7	STAG1_HUMAN	stromal antigen 1	421					cell division|chromosome segregation|mitotic metaphase/anaphase transition|mitotic prometaphase	cell junction|chromatin|chromosome, centromeric region|nucleoplasm	protein binding			NS(2)|breast(4)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(16)|lung(16)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	58						ATGTGCCGAGTACACCAAGTG	0.388000													6	35					0	0	0.307466	0	0
PLB1	151056	broad.mit.edu	37	2	28764613	28764613	+	Missense_Mutation	SNP	G	G	C			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr2:28764613G>C	ENST00000422425.2	+	13	891	c.847G>C	c.(847-849)Gag>Cag	p.E283Q	PLB1_ENST00000327757.5_Missense_Mutation_p.E272Q	NM_001170585.1	NP_001164056.1	Q6P1J6	PLB1_HUMAN	phospholipase B1	272	4 X 308-326 AA approximate repeats.				lipid catabolic process|retinoid metabolic process|steroid metabolic process	apical plasma membrane|integral to membrane	lysophospholipase activity|phospholipase A2 activity|retinyl-palmitate esterase activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(10)|lung(31)|ovary(6)|prostate(1)|skin(7)|stomach(2)	69	Acute lymphoblastic leukemia(172;0.155)					CAGGTACAGTGAGCAGGAGTC	0.592000													5	50					0	0	0.248553	0	0
PRDM9	56979	broad.mit.edu	37	5	23518018	23518018	+	Silent	SNP	G	G	T			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr5:23518018G>T	ENST00000296682.3	+	5	512	c.330G>T	c.(328-330)gtG>gtT	p.V110V		NM_020227.2	NP_064612.2	Q9NQV7	PRDM9_HUMAN	PR domain containing 9	110					meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleoplasm	histone-lysine N-methyltransferase activity|nucleic acid binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(3)|endometrium(15)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(27)|lung(87)|ovary(6)|pancreas(2)|prostate(4)|skin(10)|upper_aerodigestive_tract(11)	172						CCTTAAGAGTGGAACAGCGTA	0.403000										HNSCC(3;0.000094)			10	192					9.31168e-06	1.0957e-05	0.435327	1	0
CACNB3	784	broad.mit.edu	37	12	49221499	49221499	+	Silent	SNP	C	C	T			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr12:49221499C>T	ENST00000301050.2	+	13	1471	c.1272C>T	c.(1270-1272)caC>caT	p.H424H	CACNB3_ENST00000547392.1_Silent_p.H397H|CACNB3_ENST00000547230.1_Silent_p.H383H|CACNB3_ENST00000540990.1_Silent_p.H411H|CACNB3_ENST00000536187.2_Silent_p.H423H	NM_000725.3	NP_000716.2	P54284	CACB3_HUMAN	calcium channel, voltage-dependent, beta 3 subunit	424					axon guidance|membrane depolarization|synaptic transmission	cytosol|voltage-gated calcium channel complex	protein binding|voltage-gated calcium channel activity			autonomic_ganglia(1)|breast(1)|large_intestine(5)|lung(4)|prostate(1)	12					Verapamil(DB00661)	GCTCCCGCCACCTGGAGGAGG	0.632000													25	68					0	0	0.706142	0	0
KLHL1	57626	broad.mit.edu	37	13	70681461	70681461	+	Nonsense_Mutation	SNP	G	G	T			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr13:70681461G>T	ENST00000377844.4	-	1	1130	c.371C>A	c.(370-372)tCa>tAa	p.S124*	KLHL1_ENST00000545028.1_5'UTR|ATXN8OS_ENST00000414504.2_RNA	NM_020866.2	NP_065917.1	Q9NR64	KLHL1_HUMAN	kelch-like family member 1	124					actin cytoskeleton organization	cytoplasm|cytoskeleton	actin binding			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(11)|lung(56)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(4)|urinary_tract(1)	84		Breast(118;0.000162)		COAD - Colon adenocarcinoma(199;0.000193)|GBM - Glioblastoma multiforme(99;0.000211)		CTCCTCTAGTGACTCCACGTA	0.597000													6	54					2.0095e-06	2.41913e-06	0.248553	1	0
RSRC1	51319	broad.mit.edu	37	3	157841731	157841731	+	Missense_Mutation	SNP	G	G	T			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr3:157841731G>T	ENST00000464171.1	+	3	396	c.271G>T	c.(271-273)Ggg>Tgg	p.G91W	RSRC1_ENST00000480820.1_Missense_Mutation_p.G91W|RSRC1_ENST00000475278.2_Missense_Mutation_p.G91W|RSRC1_ENST00000295930.3_Missense_Mutation_p.G91W|RSRC1_ENST00000312179.6_Missense_Mutation_p.G91W	NM_001271834.1	NP_001258763.1	Q96IZ7	RSRC1_HUMAN	arginine/serine-rich coiled-coil 1	91	Arg/Ser-rich.				nucleocytoplasmic transport	cytoplasm|nuclear speck	protein binding	p.G91R(1)		cervix(1)|endometrium(2)|large_intestine(3)|lung(11)|upper_aerodigestive_tract(1)	18			Lung(72;0.00416)|LUSC - Lung squamous cell carcinoma(72;0.00575)			AAGGGGTCGAGGGAAATCCTA	0.383000													22	29					7.87624e-14	1.02719e-13	0.639603	1	0
GRIN2A	2903	broad.mit.edu	37	16	9858063	9858063	+	Missense_Mutation	SNP	G	G	A			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr16:9858063G>A	ENST00000396573.2	-	14	3647	c.3338C>T	c.(3337-3339)cCt>cTt	p.P1113L	GRIN2A_ENST00000404927.2_Missense_Mutation_p.P1113L|GRIN2A_ENST00000330684.3_Missense_Mutation_p.P1113L|GRIN2A_ENST00000396575.2_Missense_Mutation_p.P1113L|GRIN2A_ENST00000562109.1_Missense_Mutation_p.P1113L|GRIN2A_ENST00000535259.1_Missense_Mutation_p.P956L	NM_000833.3	NP_000824.1	Q12879	NMDE1_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 2A	1113					response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			NS(7)|breast(5)|cervix(1)|endometrium(11)|kidney(6)|large_intestine(36)|lung(71)|ovary(4)|prostate(9)|skin(45)|upper_aerodigestive_tract(2)|urinary_tract(1)	198					Felbamate(DB00949)|Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	CTTGTCTCTAGGGGAGCTTGA	0.488000													7	94					0	0	0.307466	0	0
TOPORS	10210	broad.mit.edu	37	9	32542600	32542600	+	Missense_Mutation	SNP	T	T	A			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr9:32542600T>A	ENST00000360538.2	-	3	2039	c.1923A>T	c.(1921-1923)agA>agT	p.R641S	TOPORS_ENST00000379858.1_Missense_Mutation_p.R576S	NM_005802.4	NP_005793.2	Q9NS56	TOPRS_HUMAN	topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase	641	Arg-rich.|Interaction with SUMO1.|Interaction with TOP1.|Interaction with p53/TP53.				DNA damage response, signal transduction resulting in induction of apoptosis|maintenance of protein location in nucleus|proteasomal ubiquitin-dependent protein catabolic process|protein sumoylation|transcription, DNA-dependent	nuclear speck|PML body	antigen binding|DNA binding|DNA topoisomerase I binding|SUMO ligase activity|ubiquitin-protein ligase activity|zinc ion binding			large_intestine(6)|ovary(3)|skin(2)|upper_aerodigestive_tract(1)	12			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.0018)		TCTTTTTGTCTCTTCTCCCTC	0.428000													24	166					0	0	0.693898	0	0
HCN1	348980	broad.mit.edu	37	5	45262788	45262788	+	Silent	SNP	G	G	A			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr5:45262788G>A	ENST00000303230.4	-	8	1965	c.1908C>T	c.(1906-1908)atC>atT	p.I636I		NM_021072.3	NP_066550.2	O60741	HCN1_HUMAN	hyperpolarization activated cyclic nucleotide-gated potassium channel 1	636						integral to membrane	cAMP binding|sodium channel activity|voltage-gated potassium channel activity	p.I636I(1)		NS(3)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(21)|liver(1)|lung(98)|ovary(1)|prostate(7)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(5)	156						TGATGGGAGCGATTGCCTGCA	0.478000													14	124					0	0	0.539581	0	0
MFAP5	8076	broad.mit.edu	37	12	8814677	8814677	+	Silent	SNP	C	C	G			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr12:8814677C>G	ENST00000359478.2	-	2	211	c.24G>C	c.(22-24)gtG>gtC	p.V8V	MFAP5_ENST00000433590.2_Silent_p.V8V|MFAP5_ENST00000543369.1_Silent_p.V8V|MFAP5_ENST00000540087.1_Silent_p.V8V|MFAP5_ENST00000538107.1_5'UTR|MFAP5_ENST00000535336.1_Silent_p.V8V|MFAP5_ENST00000396549.2_Silent_p.V8V	NM_003480.2	NP_003471.1	Q13361	MFAP5_HUMAN	microfibrillar associated protein 5	8						microfibril	extracellular matrix structural constituent			breast(1)|endometrium(2)|large_intestine(4)|lung(5)|skin(1)	13	Lung SC(5;0.184)					GAAACAGCAGCACCTTGGGTC	0.507000													7	25					0	0	0.307466	0	0
DACH2	117154	broad.mit.edu	37	X	85969643	85969643	+	Missense_Mutation	SNP	C	C	T			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chrX:85969643C>T	ENST00000373131.1	+	5	1148	c.985C>T	c.(985-987)Cat>Tat	p.H329Y	DACH2_ENST00000510272.1_Missense_Mutation_p.H123Y|DACH2_ENST00000373125.4_Missense_Mutation_p.H342Y|DACH2_ENST00000508860.1_Missense_Mutation_p.H175Y	NM_001139514.1	NP_001132986.1	Q96NX9	DACH2_HUMAN	dachshund homolog 2 (Drosophila)	342					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|nucleotide binding			breast(2)|central_nervous_system(3)|cervix(1)|endometrium(7)|kidney(6)|large_intestine(14)|lung(28)|ovary(5)|pancreas(1)|skin(1)|upper_aerodigestive_tract(3)	71						TCAGATGAACCATCTCAATAC	0.448000													28	207					0	0	0.760397	0	0
SETX	23064	broad.mit.edu	37	9	135203113	135203113	+	Missense_Mutation	SNP	T	T	C			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr9:135203113T>C	ENST00000372169.2	-	10	4054	c.3872A>G	c.(3871-3873)aAg>aGg	p.K1291R	SETX_ENST00000393220.1_Missense_Mutation_p.K1291R|SETX_ENST00000224140.5_Missense_Mutation_p.K1291R			Q7Z333	SETX_HUMAN	senataxin	1291					cell death|double-strand break repair|RNA processing	cytoplasm|nucleolus|nucleoplasm	ATP binding|DNA helicase activity			breast(7)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(25)|liver(1)|lung(36)|ovary(2)|prostate(2)|skin(1)|stomach(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	97		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;6.82e-06)|Epithelial(140;0.000171)		ACGAGGACCCTTTTTCAGGCC	0.438000													3	64					0	0	0.115264	0	0
UBL5	59286	broad.mit.edu	37	19	9939267	9939267	+	Splice_Site	SNP	G	G	A			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr19:9939267G>A	ENST00000358666.3	+	3	240		c.e3-1		UBL5_ENST00000590068.1_Splice_Site|UBL5_ENST00000589960.1_Intron|UBL5_ENST00000586895.1_Splice_Site|UBL5_ENST00000593087.1_Intron	NM_024292.3	NP_077268.1	Q9BZL1	UBL5_HUMAN	ubiquitin-like 5							cytoplasm				kidney(1)|lung(1)	2						TCTGCGCCCAGCACGGATGAT	0.552000													29	91					0	0	0.804634	0	0
NMUR2	56923	broad.mit.edu	37	5	151784216	151784216	+	Silent	SNP	G	G	A			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr5:151784216G>A	ENST00000255262.3	-	1	624	c.459C>T	c.(457-459)cgC>cgT	p.R153R	NMUR2_ENST00000518933.1_Intron	NM_020167.4	NP_064552.3	Q9GZQ4	NMUR2_HUMAN	neuromedin U receptor 2	153					activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|arachidonic acid secretion|calcium ion transport|central nervous system development|elevation of cytosolic calcium ion concentration|regulation of smooth muscle contraction	integral to membrane|plasma membrane	GTP binding|intracellular calcium activated chloride channel activity|neuromedin U receptor activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(12)|liver(1)|lung(15)|ovary(3)|pancreas(1)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)	44		Medulloblastoma(196;0.091)|all_hematologic(541;0.103)	Kidney(363;0.000106)|KIRC - Kidney renal clear cell carcinoma(527;0.000672)			GCAGTTTGGCGCGGAACGGGT	0.637000													10	57					0	0	0.361761	0	0
DMD	1756	broad.mit.edu	37	X	32503111	32503111	+	Missense_Mutation	SNP	C	C	A			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chrX:32503111C>A	ENST00000357033.4	-	21	2934	c.2728G>T	c.(2728-2730)Gac>Tac	p.D910Y	DMD_ENST00000378677.2_Missense_Mutation_p.D906Y	NM_000109.3|NM_004006.2|NM_004007.2|NM_004011.3|NM_004012.3|NM_004014.2	NP_000100.2|NP_003997.1|NP_003998.1|NP_004002.2|NP_004003.1|NP_004005.1	P11532	DMD_HUMAN	dystrophin	910					muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			NS(2)|breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(17)|liver(1)|lung(25)|ovary(3)|pancreas(3)|prostate(2)|skin(1)|urinary_tract(2)	77		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				GCCACAAAGTCTGCATCCAGG	0.403000													4	57					0.00909568	0.00971655	0.150653	1	0
PLK4	10733	broad.mit.edu	37	4	128807298	128807298	+	Nonsense_Mutation	SNP	C	C	A			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr4:128807298C>A	ENST00000270861.5	+	5	1047	c.773C>A	c.(772-774)tCa>tAa	p.S258*	PLK4_ENST00000514379.1_Nonsense_Mutation_p.S217*|PLK4_ENST00000515069.1_Nonsense_Mutation_p.S258*|PLK4_ENST00000513090.1_Nonsense_Mutation_p.S226*|PLK4_ENST00000507249.1_Nonsense_Mutation_p.S258*	NM_014264.4	NP_055079.3	O00444	PLK4_HUMAN	polo-like kinase 4	258	Protein kinase.				G2/M transition of mitotic cell cycle|positive regulation of centriole replication|trophoblast giant cell differentiation	centriole|cleavage furrow|cytosol|nucleolus	ATP binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(10)|lung(12)|prostate(1)|upper_aerodigestive_tract(1)	31						AGTCTGTCTTCAGTATTGGAC	0.383000													22	116					5.45024e-15	7.25926e-15	0.654019	1	0
DTX3L	151636	broad.mit.edu	37	3	122289337	122289337	+	Silent	SNP	A	A	G			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr3:122289337A>G	ENST00000296161.4	+	4	2160	c.1971A>G	c.(1969-1971)ggA>ggG	p.G657G	DTX3L_ENST00000383661.3_Silent_p.G145G	NM_138287.3	NP_612144.1	Q8TDB6	DTX3L_HUMAN	deltex 3-like (Drosophila)	657					histone monoubiquitination|response to DNA damage stimulus	cytoplasm|nucleus	histone binding|ubiquitin-protein ligase activity|zinc ion binding			breast(2)|endometrium(2)|kidney(1)|large_intestine(3)|lung(12)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	24				GBM - Glioblastoma multiforme(114;0.0459)		GATACCCTGGAATACAGCGAA	0.408000													5	44					0	0	0.217242	0	0
ABCA3	21	broad.mit.edu	37	16	2376171	2376171	+	Silent	SNP	G	G	A			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr16:2376171G>A	ENST00000301732.5	-	5	859	c.159C>T	c.(157-159)aaC>aaT	p.N53N	ABCA3_ENST00000567910.1_Silent_p.N53N|ABCA3_ENST00000382381.3_Silent_p.N53N	NM_001089.2	NP_001080.2	Q99758	ABCA3_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 3	53					response to drug	integral to membrane|lamellar body|membrane fraction|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(7)|central_nervous_system(4)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(11)|liver(1)|lung(20)|ovary(7)|prostate(5)|skin(6)|upper_aerodigestive_tract(1)	70		Ovarian(90;0.17)				AGATGGTGGCGTTGGGCACAT	0.572000													10	44					0	0	0.361761	0	0
CDH9	1007	broad.mit.edu	37	5	26881336	26881336	+	Missense_Mutation	SNP	C	C	T			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr5:26881336C>T	ENST00000231021.4	-	12	2451	c.2279G>A	c.(2278-2280)tGt>tAt	p.C760Y		NM_016279.3	NP_057363.3	Q9ULB4	CADH9_HUMAN	cadherin 9, type 2 (T1-cadherin)	760					adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding	p.C760F(1)		breast(6)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(25)|lung(80)|ovary(5)|prostate(4)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	137						ATCTTGGTTACAATCAGCTGT	0.453000													13	157					0	0	0.435327	0	0
HMGN5	79366	broad.mit.edu	37	X	80375302	80375302	+	Silent	SNP	A	A	C			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chrX:80375302A>C	ENST00000358130.2	-	3	358	c.30T>G	c.(28-30)ggT>ggG	p.G10G	HMGN5_ENST00000491275.1_5'UTR	NM_030763.2	NP_110390.1	P82970	HMGN5_HUMAN	high mobility group nucleosome binding domain 5	10					chromatin modification|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromatin|nucleolus	chromatin binding|DNA binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(3)	10						GCCTCATATCACCTTGACCTG	0.373000													5	57					0	0	0.217242	0	0
THOC2	57187	broad.mit.edu	37	X	122757749	122757749	+	Missense_Mutation	SNP	A	A	T			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chrX:122757749A>T	ENST00000245838.8	-	28	3423	c.3392T>A	c.(3391-3393)cTt>cAt	p.L1131H	THOC2_ENST00000491737.1_Missense_Mutation_p.L1016H|THOC2_ENST00000355725.4_Missense_Mutation_p.L1131H	NM_001081550.1	NP_001075019.1	Q8NI27	THOC2_HUMAN	THO complex 2	1131					intronless viral mRNA export from host nucleus|mRNA processing|RNA splicing	THO complex part of transcription export complex	protein binding|RNA binding			breast(2)|endometrium(13)|kidney(4)|large_intestine(11)|lung(26)|ovary(3)|skin(1)|upper_aerodigestive_tract(3)	63						GTACCAAGGAAGTATTTTTGT	0.378000													7	88					0	0	0.335167	0	0
TRIP12	9320	broad.mit.edu	37	2	230642091	230642091	+	Silent	SNP	T	T	C			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr2:230642091T>C	ENST00000283943.5	-	36	5422	c.5244A>G	c.(5242-5244)tcA>tcG	p.S1748S	TRIP12_ENST00000389044.4_Silent_p.S1796S|TRIP12_ENST00000389045.3_Silent_p.S1478S	NM_004238.1	NP_004229.1	Q14669	TRIPC_HUMAN	thyroid hormone receptor interactor 12	1748					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	proteasome complex	thyroid hormone receptor binding|ubiquitin-protein ligase activity			breast(2)|central_nervous_system(4)|cervix(1)|endometrium(5)|kidney(6)|large_intestine(19)|lung(32)|ovary(5)|prostate(4)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	87		Renal(207;0.025)|all_hematologic(139;0.122)|all_lung(227;0.126)|Acute lymphoblastic leukemia(138;0.164)		Epithelial(121;4.76e-13)|all cancers(144;4.34e-10)|LUSC - Lung squamous cell carcinoma(224;0.00864)|Lung(119;0.0116)		GGTGATAAACTGATCTGGCTA	0.408000													14	121					0	0	0.557998	0	0
POF1B	79983	broad.mit.edu	37	X	84600995	84600995	+	Silent	SNP	G	G	T			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chrX:84600995G>T	ENST00000262753.4	-	6	739	c.594C>A	c.(592-594)gtC>gtA	p.V198V	POF1B_ENST00000373145.3_Silent_p.V198V	NM_024921.3	NP_079197.3	Q8WVV4	POF1B_HUMAN	premature ovarian failure, 1B	198							actin binding			central_nervous_system(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(3)|liver(2)|lung(17)|ovary(1)|prostate(1)	35						CAGAGTGGATGACCTGGGGCT	0.448000													6	87					0.0215528	0.0226376	0.217242	1	0
ZNF493	284443	broad.mit.edu	37	19	21606712	21606712	+	Silent	SNP	T	T	C			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr19:21606712T>C	ENST00000392288.2	+	4	1360	c.1251T>C	c.(1249-1251)tcT>tcC	p.S417S	CTD-2561J22.3_ENST00000600810.1_Intron|ZNF493_ENST00000355504.4_Silent_p.S289S	NM_001076678.2	NP_001070146.1	Q6ZR52	ZN493_HUMAN	zinc finger protein 493	289					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(6)|lung(10)|ovary(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	30						ATAAGGAGTCTTCACACCTTA	0.348000													4	35					0	0	0.184627	0	0
ZNF518A	9849	broad.mit.edu	37	10	97918519	97918519	+	RNA	SNP	G	G	T			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr10:97918519G>T	ENST00000534948.1	+	0	3297							Q6AHZ1	Z518A_HUMAN	zinc finger protein 518A						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(4)|lung(8)|ovary(1)|prostate(2)|urinary_tract(2)	24		Colorectal(252;0.0815)		Epithelial(162;4.23e-08)|all cancers(201;1.85e-06)		ACTTCATTGTGACCAGTCATT	0.398000													7	23					0.248553	0.250151	0.248553	1	0
FAT4	79633	broad.mit.edu	37	4	126411330	126411330	+	Silent	SNP	T	T	C			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr4:126411330T>C	ENST00000394329.3	+	17	13366	c.13353T>C	c.(13351-13353)tgT>tgC	p.C4451C	FAT4_ENST00000335110.5_Silent_p.C2692C	NM_024582.4	NP_078858.4	Q6V0I7	FAT4_HUMAN	FAT atypical cadherin 4	4451	EGF-like 6.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						GCTTCACCTGTAGCTGCCCAG	0.622000													6	61					0	0	0.248553	0	0
PGBD1	84547	broad.mit.edu	37	6	28269577	28269577	+	Missense_Mutation	SNP	C	C	T			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr6:28269577C>T	ENST00000405948.2	+	7	2366	c.1946C>T	c.(1945-1947)aCa>aTa	p.T649I	PGBD1_ENST00000259883.3_Missense_Mutation_p.T649I	NM_001184743.1|NM_032507.3	NP_001171672.1|NP_115896.1	Q96JS3	PGBD1_HUMAN	piggyBac transposable element derived 1	649					viral reproduction	membrane|nucleus	scavenger receptor activity|sequence-specific DNA binding transcription factor activity			endometrium(2)|kidney(2)|large_intestine(7)|lung(16)|ovary(4)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)	41						GCAACAGGAACAATTCGTGAG	0.388000													6	61					0	0	0.217242	0	0
KALRN	8997	broad.mit.edu	37	3	124103822	124103822	+	Missense_Mutation	SNP	G	G	C			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr3:124103822G>C	ENST00000360013.3	+	11	2022	c.1895G>C	c.(1894-1896)aGg>aCg	p.R632T	KALRN_ENST00000460856.1_Missense_Mutation_p.R632T|KALRN_ENST00000240874.3_Missense_Mutation_p.R632T	NM_001024660.3	NP_001019831.2	O60229	KALRN_HUMAN	kalirin, RhoGEF kinase	632					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|vesicle-mediated transport	actin cytoskeleton|cytosol	ATP binding|GTPase activator activity|metal ion binding|protein binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(21)|lung(28)|ovary(4)|prostate(5)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	83						TTCGTGCGCAGGGTGGAGCAG	0.582000													27	54					0	0	0.706142	0	0
TAF7L	54457	broad.mit.edu	37	X	100542529	100542529	+	Missense_Mutation	SNP	C	C	T			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chrX:100542529C>T	ENST00000372907.3	-	2	272	c.261G>A	c.(259-261)atG>atA	p.M87I	TAF7L_ENST00000372905.2_Start_Codon_SNP_p.M1I|TAF7L_ENST00000356784.1_Start_Codon_SNP_p.M1I|TAF7L_ENST00000324762.6_Start_Codon_SNP_p.M1I	NM_024885.3	NP_079161.3	Q5H9L4	TAF7L_HUMAN	TAF7-like RNA polymerase II, TATA box binding protein (TBP)-associated factor, 50kDa	87					cell differentiation|multicellular organismal development|regulation of transcription, DNA-dependent|spermatogenesis|transcription initiation from RNA polymerase II promoter	cytoplasm|transcription factor TFIID complex	binding			NS(1)|breast(4)|kidney(4)|large_intestine(4)|lung(7)|ovary(1)|pancreas(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	29						GGCTTTCACTCATGTCTTGAT	0.383000													11	56					0	0	0.435327	0	0
SNHG14	104472715	broad.mit.edu	37	15	25475894	25475894	+	RNA	SNP	C	C	A			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr15:25475894C>A	ENST00000453082.2	+	0	1489					NR_003343.1																						TGCACTGAAGCTCCAGCCCTT	0.607000													4	18					0.150653	0.153598	0.150653	1	0
PHKA1	5255	broad.mit.edu	37	X	71840620	71840620	+	Missense_Mutation	SNP	C	C	G			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chrX:71840620C>G	ENST00000339490.3	-	19	2392	c.2092G>C	c.(2092-2094)Gac>Cac	p.D698H	PHKA1_ENST00000373539.3_Missense_Mutation_p.D698H|PHKA1_ENST00000373542.4_Missense_Mutation_p.D698H|PHKA1_ENST00000373545.3_Intron|PHKA1_ENST00000541944.1_Intron	NM_001122670.1	NP_001116142.1	P46020	KPB1_HUMAN	phosphorylase kinase, alpha 1 (muscle)	698					glucose metabolic process|glycogen catabolic process	cytosol|plasma membrane	calmodulin binding|glucan 1,4-alpha-glucosidase activity|phosphorylase kinase activity			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(9)|liver(2)|lung(18)|ovary(3)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	52	Renal(35;0.156)					GACATTAAGTCGCAGGTTGTT	0.537000													8	84					0	0	0.411799	0	0
COL12A1	1303	broad.mit.edu	37	6	75813501	75813501	+	Missense_Mutation	SNP	C	C	A			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr6:75813501C>A	ENST00000322507.8	-	55	8600	c.8291G>T	c.(8290-8292)aGa>aTa	p.R2764I	COL12A1_ENST00000416123.2_Missense_Mutation_p.R2688I|COL12A1_ENST00000483888.2_Missense_Mutation_p.R2764I|COL12A1_ENST00000345356.6_Missense_Mutation_p.R1600I	NM_004370.5	NP_004361.3	Q99715	COCA1_HUMAN	collagen, type XII, alpha 1	2764	Triple-helical region (COL2) with 1 imperfection.				cell adhesion|collagen fibril organization|skeletal system development	collagen type XII|extracellular space	extracellular matrix structural constituent conferring tensile strength			breast(7)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(5)|kidney(5)|large_intestine(44)|liver(1)|lung(77)|ovary(7)|prostate(3)|skin(4)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(2)	169						TCTTTCACCTCTGGGACCTTT	0.358000													6	70					0.00621372	0.00670653	0.335167	1	0
ATRX	546	broad.mit.edu	37	X	76890157	76890157	+	Silent	SNP	C	C	A			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chrX:76890157C>A	ENST00000373344.5	-	17	4951	c.4737G>T	c.(4735-4737)gtG>gtT	p.V1579V	ATRX_ENST00000395603.3_Silent_p.V1541V|ATRX_ENST00000480283.1_5'UTR	NM_000489.3	NP_000480.2	P46100	ATRX_HUMAN	alpha thalassemia/mental retardation syndrome X-linked	1579					DNA methylation|DNA recombination|DNA repair|regulation of transcription, DNA-dependent	nuclear heterochromatin	ATP binding|chromo shadow domain binding|DNA binding|DNA helicase activity|zinc ion binding	p.?(1)		bone(1)|breast(6)|central_nervous_system(31)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(15)|kidney(14)|large_intestine(1)|liver(1)|lung(40)|ovary(2)|pancreas(13)|prostate(5)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	145					Phosphatidylserine(DB00144)	TTGTTTTTTTCACAGACTCAC	0.368000			"""Mis, F, N"""		"""Pancreatic neuroendocrine tumors, paediatric GBM"""		ATR-X (alpha thalassemia/mental retardation) syndrome						25	152					1.36161e-19	1.90261e-19	0.796494	1	0
MED12	9968	broad.mit.edu	37	X	70348217	70348217	+	Missense_Mutation	SNP	G	G	A			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chrX:70348217G>A	ENST00000333646.6	+	23	3480	c.3281G>A	c.(3280-3282)gGa>gAa	p.G1094E	MED12_ENST00000374080.3_Missense_Mutation_p.G1094E|MED12_ENST00000374102.1_Missense_Mutation_p.G1094E	NM_005120.2	NP_005111.2	Q93074	MED12_HUMAN	mediator complex subunit 12	1094					androgen receptor signaling pathway|negative regulation of Wnt receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|protein C-terminus binding|protein domain specific binding|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			breast(6)|central_nervous_system(2)|endometrium(22)|kidney(5)|large_intestine(8)|lung(31)|ovary(2)|pancreas(1)|prostate(11)|skin(5)|soft_tissue(323)|upper_aerodigestive_tract(1)|urinary_tract(3)	420	Renal(35;0.156)					GAATGGCTAGGAGTGCTTAAG	0.498000			"""M, S"""		uterine leiomyoma		Opitz-Kaveggia Syndrome						41	165					0	0	0.859065	0	0
CES5A	221223	broad.mit.edu	37	16	55880393	55880393	+	Silent	SNP	G	G	T			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr16:55880393G>T	ENST00000521992.1	-	14	1930	c.1785C>A	c.(1783-1785)ctC>ctA	p.L595L	CES5A_ENST00000290567.9_Silent_p.L566L|CES5A_ENST00000520435.1_Silent_p.L536L|CES5A_ENST00000518005.1_Silent_p.L460L|CES5A_ENST00000541580.1_5'UTR|CES5A_ENST00000319165.9_Silent_p.L516L	NM_001190158.1	NP_001177087.1	Q6NT32	EST5A_HUMAN	carboxylesterase 5A	566						extracellular region	carboxylesterase activity|methyl indole-3-acetate esterase activity|methyl jasmonate esterase activity|methyl salicylate esterase activity			breast(2)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(8)|lung(13)|ovary(4)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	39						AGAAAGGCTGGAGGAGAGAGA	0.468000													10	96					0.000673444	0.000744834	0.361761	1	0
OR52D1	390066	broad.mit.edu	37	11	5510860	5510860	+	Silent	SNP	A	A	G			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr11:5510860A>G	ENST00000322641.5	+	1	946	c.924A>G	c.(922-924)ctA>ctG	p.L308L	AC104389.28_ENST00000415970.1_RNA|HBE1_ENST00000380237.1_Intron|HBG2_ENST00000380259.2_Intron|HBG2_ENST00000380252.1_Intron	NM_001005163.2	NP_001005163.1	Q9H346	O52D1_HUMAN	olfactory receptor, family 52, subfamily D, member 1	308					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|cervix(1)|endometrium(3)|large_intestine(5)|lung(8)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	22		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;3.46e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GTCGACTTCTAAAACTGCTTC	0.423000													11	54					0	0	0.387290	0	0
NRDE2	55051	broad.mit.edu	37	14	90764693	90764693	+	Missense_Mutation	SNP	C	C	A			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr14:90764693C>A	ENST00000354366.3	-	8	1809	c.1577G>T	c.(1576-1578)gGa>gTa	p.G526V	NRDE2_ENST00000357904.3_Missense_Mutation_p.G295V	NM_017970.3	NP_060440.2			NRDE-2, necessary for RNA interference, domain containing																		CCGGGGCTCTCCACTGTCCCA	0.542000													3	27					0.115264	0.118287	0.115264	1	0
PEG3	5178	broad.mit.edu	37	19	57326922	57326922	+	Missense_Mutation	SNP	C	C	T			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr19:57326922C>T	ENST00000326441.9	-	10	3251	c.2888G>A	c.(2887-2889)cGc>cAc	p.R963H	ZIM2_ENST00000599935.1_Intron|ZIM2_ENST00000601070.1_Intron|PEG3_ENST00000593695.1_Missense_Mutation_p.R837H|ZIM2_ENST00000593711.1_Intron|ZIM2_ENST00000391708.3_Intron|PEG3_ENST00000423103.2_Missense_Mutation_p.R963H|PEG3_ENST00000598410.1_Missense_Mutation_p.R839H|ZIM2_ENST00000221722.5_Intron	NM_006210.2	NP_006201.1	Q9GZU2	PEG3_HUMAN	paternally expressed 3	963					apoptosis|viral reproduction	cytoplasm|nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|biliary_tract(4)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(27)|lung(84)|ovary(8)|pancreas(5)|prostate(6)|skin(8)|stomach(2)|upper_aerodigestive_tract(6)	170		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0269)		CCCTCGAGGGCGAAATGTTTG	0.473000													42	109					0	0	0.853193	0	0
CSNK1A1L	122011	broad.mit.edu	37	13	37679150	37679150	+	Missense_Mutation	SNP	C	C	T			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr13:37679150C>T	ENST00000379800.3	-	1	653	c.244G>A	c.(244-246)Gaa>Aaa	p.E82K		NM_145203.5	NP_660204.2	Q8N752	KC1AL_HUMAN	casein kinase 1, alpha 1-like	82	Protein kinase.				Wnt receptor signaling pathway	cytoplasm	ATP binding|protein serine/threonine kinase activity			NS(1)|breast(3)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(10)|lung(11)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	37		Lung NSC(96;7.97e-05)|Breast(139;0.0615)|Lung SC(185;0.0743)|Prostate(109;0.109)		all cancers(112;3.58e-07)|Epithelial(112;1.29e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00695)|BRCA - Breast invasive adenocarcinoma(63;0.0117)|GBM - Glioblastoma multiforme(144;0.0407)		TTGTCTTTTTCCTGACCATAC	0.468000													15	57					0	0	0.520397	0	0
COL19A1	1310	broad.mit.edu	37	6	70861292	70861292	+	Missense_Mutation	SNP	G	G	T			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr6:70861292G>T	ENST00000322773.4	+	31	2143	c.2041G>T	c.(2041-2043)Gca>Tca	p.A681S	COL19A1_ENST00000393344.1_Missense_Mutation_p.A303S	NM_001858.4	NP_001849.2	Q14993	COJA1_HUMAN	collagen, type XIX, alpha 1	681	Triple-helical region 3 (COL3).				cell differentiation|cell-cell adhesion|extracellular matrix organization|skeletal system development	collagen	extracellular matrix structural constituent|protein binding, bridging			breast(4)|central_nervous_system(3)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(5)|kidney(4)|large_intestine(8)|lung(54)|ovary(3)|prostate(2)|skin(10)|upper_aerodigestive_tract(4)|urinary_tract(2)	109						ACCACAGATTGCACTTCCTCT	0.308000													17	69					6.21321e-17	8.45537e-17	0.639603	1	0
DCAF12L2	340578	broad.mit.edu	37	X	125298774	125298774	+	Silent	SNP	G	G	A			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chrX:125298774G>A	ENST00000538699.1	-	2	1214	c.1134C>T	c.(1132-1134)cgC>cgT	p.R378R	DCAF12L2_ENST00000360028.2_Silent_p.R378R	NM_001013628.2	NP_001013650.1	Q5VW00	DC122_HUMAN	DDB1 and CUL4 associated factor 12-like 2	378										NS(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(11)|lung(36)|ovary(2)|pancreas(1)|skin(2)|upper_aerodigestive_tract(3)	64						ACTTCTGGGCGCGGATGTCAT	0.642000													6	129					0	0	0.278610	0	0
SH3BGRL	6451	broad.mit.edu	37	X	80532613	80532613	+	Missense_Mutation	SNP	C	C	A			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chrX:80532613C>A	ENST00000373212.5	+	2	434	c.176C>A	c.(175-177)cCa>cAa	p.P59Q	SH3BGRL_ENST00000481106.1_3'UTR	NM_003022.2	NP_003013.1	O75368	SH3L1_HUMAN	SH3 domain binding glutamic acid-rich protein like	59						cytoplasm|nucleus	SH3 domain binding|SH3/SH2 adaptor activity			endometrium(1)|lung(2)|ovary(1)	4		all_lung(315;5.94e-05)				AATAGTCGACCAGCCACAGGT	0.398000													4	68					1.23904e-05	1.42058e-05	0.184627	1	0
NKAIN3	286183	broad.mit.edu	37	8	63659576	63659576	+	Missense_Mutation	SNP	C	C	T			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr8:63659576C>T	ENST00000523211.1	+	4	491	c.359C>T	c.(358-360)cCt>cTt	p.P120L	NKAIN3_ENST00000519049.1_3'UTR|NKAIN3_ENST00000328472.5_Missense_Mutation_p.P120L	NM_173688.2	NP_775959.1	Q8N8D7	NKAI3_HUMAN	Na+/K+ transporting ATPase interacting 3	120						integral to membrane|plasma membrane				kidney(3)|large_intestine(2)|lung(8)	13	Breast(64;0.127)	Lung NSC(129;0.187)				AGAGTGCTGCCTCCCTCAGCC	0.522000													3	42					0	0	0.150653	0	0
IFT20	90410	broad.mit.edu	37	17	26659009	26659009	+	Missense_Mutation	SNP	C	C	T			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr17:26659009C>T	ENST00000585089.1	-	3	351	c.81G>A	c.(79-81)atG>atA	p.M27I	IFT20_ENST00000578985.1_Missense_Mutation_p.M27I|IFT20_ENST00000578122.1_Missense_Mutation_p.M27I|IFT20_ENST00000395418.3_Start_Codon_SNP_p.M1I|IFT20_ENST00000357896.3_Start_Codon_SNP_p.M1I|IFT20_ENST00000585313.1_Start_Codon_SNP_p.M1I|IFT20_ENST00000579419.1_Start_Codon_SNP_p.M1I	NM_001267774.1	NP_001254703.1	Q8IY31	IFT20_HUMAN	intraflagellar transport 20 homolog (Chlamydomonas)	1					cell projection organization	centriole|cilium|Golgi apparatus|microtubule basal body	protein binding			lung(2)	2	all_lung(13;0.000294)|Lung NSC(42;0.000964)			UCEC - Uterine corpus endometrioid carcinoma (53;0.153)		TGTCCTTGGCCATGGCTGTAA	0.552000													34	64					0	0	0.827153	0	0
LEPR	3953	broad.mit.edu	37	1	66058391	66058391	+	Silent	SNP	G	G	A			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr1:66058391G>A	ENST00000349533.6	+	6	731	c.546G>A	c.(544-546)caG>caA	p.Q182Q	LEPR_ENST00000371060.3_Silent_p.Q182Q|LEPR_ENST00000462765.1_3'UTR|LEPR_ENST00000344610.8_Silent_p.Q182Q|LEPR_ENST00000406510.3_Intron|LEPR_ENST00000371058.1_Silent_p.Q182Q|LEPR_ENST00000371059.3_Silent_p.Q182Q	NM_002303.5	NP_002294.2	P48357	LEPR_HUMAN	leptin receptor	182					energy reserve metabolic process|multicellular organismal development	extracellular region|integral to membrane|plasma membrane	cytokine receptor activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(22)|skin(2)	36				OV - Ovarian serous cystadenocarcinoma(397;0.00722)|KIRC - Kidney renal clear cell carcinoma(1967;0.094)		GCAGTTTTCAGATGGTTCACT	0.378000													11	69					0	0	0.479597	0	0
SYNPO2	171024	broad.mit.edu	37	4	119944647	119944647	+	Silent	SNP	C	C	T			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr4:119944647C>T	ENST00000307142.4	+	2	364	c.168C>T	c.(166-168)atC>atT	p.I56I	SYNPO2_ENST00000448416.2_Silent_p.I56I|SYNPO2_ENST00000429713.2_Silent_p.I56I|SYNPO2_ENST00000434046.2_Silent_p.I56I	NM_133477.2	NP_597734.2	Q9UMS6	SYNP2_HUMAN	synaptopodin 2	56	PDZ.					nucleus|Z disc	14-3-3 protein binding|actin binding|muscle alpha-actinin binding	p.I56I(2)		breast(3)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(20)|lung(18)|ovary(2)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	64						TGGTTTCCATCAATGGCAACC	0.438000													7	76					0	0	0.278610	0	0
PCDHGC5	56097	broad.mit.edu	37	5	140870425	140870425	+	Missense_Mutation	SNP	G	G	A			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr5:140870425G>A	ENST00000252087.1	+	1	1618	c.1618G>A	c.(1618-1620)Ggc>Agc	p.G540S	PCDHGB1_ENST00000523390.1_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGB4_ENST00000519479.1_Intron|PCDHGA7_ENST00000518325.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGA6_ENST00000517434.1_Intron|PCDHGA9_ENST00000573521.1_Intron|PCDHGB6_ENST00000520790.1_Intron|PCDHGA11_ENST00000518882.1_Intron|PCDHGA11_ENST00000398587.2_Intron|PCDHGB7_ENST00000398594.2_Intron|PCDHGA8_ENST00000398604.2_Intron|PCDHGA10_ENST00000398610.2_Intron|PCDHGB3_ENST00000576222.1_Intron|PCDHGC3_ENST00000308177.3_Intron|PCDHGC4_ENST00000306593.1_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGA12_ENST00000252085.3_Intron|PCDHGA5_ENST00000518069.1_Intron	NM_018929.2|NM_032403.2|NM_032407.1	NP_061752.1|NP_115779.1|NP_115783.1	Q9Y5F6	PCDGM_HUMAN		540	Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(2)|central_nervous_system(2)|endometrium(6)|kidney(4)|large_intestine(4)|lung(10)|ovary(4)|prostate(1)|urinary_tract(2)	35			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCGAGACTCCGGCTCTCCCCC	0.537000													8	79					0	0	0.307466	0	0
SEC31B	25956	broad.mit.edu	37	10	102258531	102258531	+	Missense_Mutation	SNP	C	C	A			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr10:102258531C>A	ENST00000370345.3	-	14	1712	c.1615G>T	c.(1615-1617)Gct>Tct	p.A539S	SEC31B_ENST00000494350.1_5'UTR	NM_015490.3	NP_056305.1	Q9NQW1	SC31B_HUMAN	SEC31 homolog B (S. cerevisiae)	539					protein transport|vesicle-mediated transport	endoplasmic reticulum membrane|ER to Golgi transport vesicle membrane				NS(1)|breast(2)|cervix(1)|endometrium(6)|kidney(4)|large_intestine(3)|lung(17)|ovary(1)|urinary_tract(1)	36		Colorectal(252;0.117)		Epithelial(162;2.36e-10)|all cancers(201;2.09e-08)		GCTGAGGAAGCAGAGGCTTCC	0.527000													10	64					3.03607e-14	3.97611e-14	0.411799	1	0
PCDH19	57526	broad.mit.edu	37	X	99596916	99596916	+	Nonsense_Mutation	SNP	G	G	A			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chrX:99596916G>A	ENST00000373034.4	-	5	4508	c.2833C>T	c.(2833-2835)Cag>Tag	p.Q945*	PCDH19_ENST00000420881.2_Nonsense_Mutation_p.Q897*|PCDH19_ENST00000255531.7_Nonsense_Mutation_p.Q898*	NM_001184880.1	NP_001171809.1	Q8TAB3	PCD19_HUMAN	protocadherin 19	945					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(5)|endometrium(11)|kidney(1)|large_intestine(14)|liver(1)|lung(23)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	68						TCAGGCATCTGAGATCCCATG	0.463000													9	71					0	0	0.335167	0	0
VAMP7	6845	broad.mit.edu	37	X	155125334	155125334	+	Silent	SNP	C	C	T			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chrX:155125334C>T	ENST00000286448.6	+	3	360	c.195C>T	c.(193-195)atC>atT	p.I65I	VAMP7_ENST00000479687.1_3'UTR|VAMP7_ENST00000262640.6_Silent_p.I65I|VAMP7_ENST00000460621.1_Intron	NM_001145149.2|NM_005638.5	NP_001138621.1|NP_005629.1	P51809	VAMP7_HUMAN	vesicle-associated membrane protein 7	65	Longin.				calcium ion-dependent exocytosis|endosome to lysosome transport|eosinophil degranulation|ER to Golgi vesicle-mediated transport|neutrophil degranulation|phagocytosis, engulfment|post-Golgi vesicle-mediated transport|protein transport|vesicle fusion	endoplasmic reticulum membrane|Golgi apparatus|integral to membrane|late endosome membrane|lysosomal membrane|phagocytic vesicle membrane|plasma membrane|SNARE complex|transport vesicle membrane	protein binding			large_intestine(1)|lung(8)	9	all_cancers(53;1.86e-17)|all_epithelial(53;2.71e-11)|all_lung(58;1.84e-07)|Lung NSC(58;5.62e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)					ATCTTTGTATCACTGATGATG	0.333000													10	79					0	0	0.435327	0	0
PRAMEF4	400735	broad.mit.edu	37	1	12941866	12941866	+	Silent	SNP	T	T	C			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr1:12941866T>C	ENST00000235349.5	-	3	754	c.684A>G	c.(682-684)ccA>ccG	p.P228P		NM_001009611.2	NP_001009611.1	O60810	PRAM4_HUMAN	PRAME family member 4	228										breast(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(10)|ovary(2)|prostate(3)|skin(1)	24	Ovarian(185;0.249)	Lung NSC(185;3.67e-05)|all_lung(284;4.03e-05)|Renal(390;0.000147)|Breast(348;0.000278)|Colorectal(325;0.00058)|Ovarian(437;0.00965)|Hepatocellular(190;0.0245)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;4.88e-06)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|COAD - Colon adenocarcinoma(227;0.000241)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		GGCCCAGGTATGGGGTAAACT	0.483000													45	209					0	0	0.870114	0	0
MROH2B	133558	broad.mit.edu	37	5	41058239	41058239	+	Nonsense_Mutation	SNP	C	C	A			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr5:41058239C>A	ENST00000399564.4	-	7	1132	c.682G>T	c.(682-684)Gga>Tga	p.G228*	MROH2B_ENST00000506092.2_5'UTR	NM_173489.4	NP_775760.3			maestro heat-like repeat family member 2B									p.G228*(1)									AGGGCGTATCCACGGAAGTCT	0.517000													3	37					1.23904e-05	1.42058e-05	0.184627	1	0
IL36RN	26525	broad.mit.edu	37	2	113819803	113819803	+	Missense_Mutation	SNP	G	G	C			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr2:113819803G>C	ENST00000393200.2	+	4	379	c.218G>C	c.(217-219)gGg>gCg	p.G73A	IL36RN_ENST00000346807.3_Missense_Mutation_p.G73A	NM_012275.2	NP_036407.1	Q9UBH0	I36RA_HUMAN	interleukin 36 receptor antagonist	73						extracellular space	cytokine activity|interleukin-1 receptor antagonist activity			large_intestine(3)|lung(5)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	11						TGTGGGGTGGGGCAGGAGCCG	0.632000													9	87					0	0	0.361761	0	0
LEPROT	54741	broad.mit.edu	37	1	65895576	65895576	+	Missense_Mutation	SNP	C	C	T			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr1:65895576C>T	ENST00000371065.4	+	3	262	c.124C>T	c.(124-126)Cac>Tac	p.H42Y	LEPR_ENST00000371060.3_Intron|LEPR_ENST00000349533.6_Intron|LEPROT_ENST00000484243.1_3'UTR|LEPR_ENST00000344610.8_Intron|LEPR_ENST00000406510.3_Intron|LEPR_ENST00000371059.3_Intron	NM_001198681.1|NM_017526.4	NP_001185610.1|NP_059996.1	O15243	OBRG_HUMAN	leptin receptor overlapping transcript	42						endosome membrane|Golgi membrane|integral to plasma membrane				kidney(1)|large_intestine(1)|lung(5)	7				OV - Ovarian serous cystadenocarcinoma(397;0.00722)|KIRC - Kidney renal clear cell carcinoma(1967;0.094)		CCTGATTTTCCACGCCATCTC	0.438000													28	171					0	0	0.796494	0	0
SPATA18	132671	broad.mit.edu	37	4	52943078	52943078	+	Missense_Mutation	SNP	C	C	A			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr4:52943078C>A	ENST00000295213.4	+	7	1266	c.892C>A	c.(892-894)Cgc>Agc	p.R298S	SPATA18_ENST00000419395.2_Missense_Mutation_p.R266S	NM_145263.2	NP_660306.1	Q8TC71	MIEAP_HUMAN	spermatogenesis associated 18	298	Ser-rich.				mitochondrial protein catabolic process|mitochondrion degradation by induced vacuole formation|response to DNA damage stimulus	mitochondrial outer membrane	protein binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(8)|lung(20)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	41			GBM - Glioblastoma multiforme(4;1.77e-13)|LUSC - Lung squamous cell carcinoma(32;0.00204)			CAATGTGGCGCGCAAGGCTGC	0.657000													4	41					3.59834e-05	4.03684e-05	0.217242	1	0
LRRC37A4P	55073	broad.mit.edu	37	17	43587657	43587657	+	RNA	SNP	C	C	T	rs148404065	by1000genomes	TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr17:43587657C>T	ENST00000253803.2	+	0	267				LRRC37A4P_ENST00000579913.1_RNA																							GGTGACAACACATCTGTTTTA	0.323000													5	44					0	0	0.184627	0	0
SHROOM2	357	broad.mit.edu	37	X	9862786	9862786	+	Missense_Mutation	SNP	C	C	G			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chrX:9862786C>G	ENST00000380913.3	+	4	928	c.838C>G	c.(838-840)Ccc>Gcc	p.P280A		NM_001649.2	NP_001640.1	Q13796	SHRM2_HUMAN	shroom family member 2	280					apical protein localization|brain development|cell migration|cell morphogenesis|cellular pigment accumulation|ear development|establishment of melanosome localization|eye pigment granule organization|lens morphogenesis in camera-type eye|melanosome organization	apical plasma membrane|cell-cell adherens junction|microtubule|tight junction	actin filament binding|beta-catenin binding|ligand-gated sodium channel activity			breast(4)|central_nervous_system(2)|cervix(3)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(13)|ovary(3)|prostate(3)|skin(6)|upper_aerodigestive_tract(2)	57		Hepatocellular(5;0.000888)				CGGCAAAGGCCCCAGGCCAGA	0.642000													3	29					0	0	0.115264	0	0
TMEM64	169200	broad.mit.edu	37	8	91643780	91643780	+	Splice_Site	SNP	C	C	T			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr8:91643780C>T	ENST00000458549.2	-	2	1128	c.951_splice	c.e2+1	p.Q317_splice	TMEM64_ENST00000519519.1_Splice_Site_p.Q56_splice|TMEM64_ENST00000418210.2_Intron	NM_001008495.3	NP_001008495.2	Q6YI46	TMM64_HUMAN	transmembrane protein 64	317						integral to membrane				endometrium(1)|large_intestine(1)	2			BRCA - Breast invasive adenocarcinoma(11;0.0598)			TTAAACTCACCTGTAAACAAA	0.383000													7	79					0	0	0.278610	0	0
ROS1	6098	broad.mit.edu	37	6	117687261	117687261	+	Silent	SNP	C	C	T			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr6:117687261C>T	ENST00000368508.3	-	18	2988	c.2790G>A	c.(2788-2790)caG>caA	p.Q930Q	ROS1_ENST00000368507.3_Silent_p.Q925Q|GOPC_ENST00000467125.1_Intron	NM_002944.2	NP_002935.2	P08922	ROS_HUMAN	c-ros oncogene 1 , receptor tyrosine kinase	930					transmembrane receptor protein tyrosine kinase signaling pathway	membrane fraction|sodium:potassium-exchanging ATPase complex	ATP binding|transmembrane receptor protein tyrosine kinase activity		TPM3_ENST00000368530/ROS1(4)|LRIG3/ROS1(2)|CD74_ENST00000009530/ROS1(32)|SLC34A2/ROS1(14)|EZR/ROS1(4)|GOPC/ROS1(14)|SDC4/ROS1(7)	NS(2)|breast(7)|central_nervous_system(5)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(28)|lung(56)|ovary(8)|prostate(5)|skin(19)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(3)	162		all_cancers(87;0.00846)|all_epithelial(87;0.0242)		GBM - Glioblastoma multiforme(226;0.0387)|OV - Ovarian serous cystadenocarcinoma(136;0.0954)|all cancers(137;0.137)		TAAGGGATGTCTGAATAATTG	0.378000			T	"""GOPC, SDC4, SLC34A2, EZR, LRIG3"""	"""glioblastoma, NSCLC"""								11	131					0	0	0.479597	0	0
ROBO2	6092	broad.mit.edu	37	3	77651359	77651359	+	Splice_Site	SNP	A	A	T			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr3:77651359A>T	ENST00000461745.1	+	20	3754		c.e20-1		ROBO2_ENST00000487694.3_Splice_Site|ROBO2_ENST00000332191.8_Splice_Site	NM_002942.4	NP_002933.1	Q9HCK4	ROBO2_HUMAN	roundabout, axon guidance receptor, homolog 2 (Drosophila)						apoptosis involved in luteolysis|axon midline choice point recognition|cellular response to hormone stimulus|homophilic cell adhesion|metanephros development|negative regulation of negative chemotaxis|negative regulation of synaptogenesis|olfactory bulb interneuron development|positive regulation of axonogenesis|retinal ganglion cell axon guidance|ureteric bud development	axolemma|cell surface|integral to membrane	axon guidance receptor activity|identical protein binding			NS(1)|biliary_tract(5)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(23)|liver(1)|lung(52)|ovary(2)|pancreas(2)|prostate(5)|skin(8)|upper_aerodigestive_tract(1)	117				Epithelial(33;0.00199)|LUSC - Lung squamous cell carcinoma(21;0.008)|BRCA - Breast invasive adenocarcinoma(55;0.00884)|Lung(72;0.0183)|KIRC - Kidney renal clear cell carcinoma(39;0.0832)|Kidney(39;0.103)		TGTTCACCACAGATGTGCTGC	0.443000													7	43					0	0	0.335167	0	0
BTN2A3P	54718	broad.mit.edu	37	6	26431645	26431645	+	RNA	SNP	G	G	T			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr6:26431645G>T	ENST00000466808.2	+	0	1593																											TGCCTCTGGTGGAAGACACGC	0.577000													27	76					7.26314e-15	9.6329e-15	0.717897	1	0
FRG1B	284802	broad.mit.edu	37	20	29625877	29625877	+	Missense_Mutation	SNP	G	G	A	rs7266938	by1000genomes	TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr20:29625877G>A	ENST00000278882.3	+	5	501	c.121G>A	c.(121-123)Gcc>Acc	p.A41T	FRG1B_ENST00000358464.4_Missense_Mutation_p.A41T|FRG1B_ENST00000439954.2_Missense_Mutation_p.A46T														p.A41T(2)		endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						GTACAGAATCGCCCTGAAATC	0.358000													6	47					0	0	0.248553	0	0
IFT57	55081	broad.mit.edu	37	3	107938420	107938420	+	Splice_Site	SNP	C	C	G			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr3:107938420C>G	ENST00000264538.3	-	2	460		c.e2-1			NM_018010.3	NP_060480.1	Q9NWB7	IFT57_HUMAN	intraflagellar transport 57 homolog (Chlamydomonas)						activation of caspase activity|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cilium|microtubule basal body	DNA binding|protein binding			kidney(1)|large_intestine(2)|lung(4)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|urinary_tract(2)	14			OV - Ovarian serous cystadenocarcinoma(3;0.0428)|Epithelial(53;0.246)			AAAATAGTGTCTGTTTCAAAA	0.413000													12	71					0	0	0.520397	0	0
INSRR	3645	broad.mit.edu	37	1	156815425	156815425	+	Silent	SNP	C	C	T			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr1:156815425C>T	ENST00000368195.3	-	10	2556	c.2160G>A	c.(2158-2160)gcG>gcA	p.A720A	NTRK1_ENST00000392302.2_Intron	NM_014215.2	NP_055030.1	P14616	INSRR_HUMAN	insulin receptor-related receptor	720					protein autophosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|insulin receptor substrate binding|metal ion binding|phosphatidylinositol 3-kinase binding|transmembrane receptor protein tyrosine kinase activity	p.A720A(1)		breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(13)|ovary(7)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)	42	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					GGATGGTGATCGCGTTGTGTA	0.637000													5	45					0	0	0.248553	0	0
DCAF4	26094	broad.mit.edu	37	14	73420894	73420894	+	Silent	SNP	C	C	T			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr14:73420894C>T	ENST00000553457.1	+	9	821	c.531C>T	c.(529-531)ctC>ctT	p.L177L	DCAF4_ENST00000358377.2_Silent_p.L277L|DCAF4_ENST00000509153.1_Silent_p.L217L|DCAF4_ENST00000394234.2_Silent_p.L177L|DCAF4_ENST00000353777.3_Intron|DCAF4_ENST00000555042.1_Silent_p.L278L			Q8WV16	DCAF4_HUMAN	DDB1 and CUL4 associated factor 4	277						CUL4 RING ubiquitin ligase complex				NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(6)|ovary(1)|skin(1)	22						CTGGCATGCTCTGCAGTTTCC	0.567000													39	252					0	0	0.870114	0	0
JMJD6	23210	broad.mit.edu	37	17	74720119	74720119	+	Silent	SNP	T	T	C			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr17:74720119T>C	ENST00000445478.2	-	3	743	c.540A>G	c.(538-540)ccA>ccG	p.P180P	JMJD6_ENST00000397625.4_Silent_p.P180P|JMJD6_ENST00000585429.1_Silent_p.P180P	NM_001081461.1	NP_001074930.1	Q6NYC1	JMJD6_HUMAN	jumonji domain containing 6	180	JmjC.				mRNA processing|peptidyl-lysine hydroxylation to 5-hydroxy-L-lysine|regulation of nuclear mRNA splicing, via spliceosome|regulation of transcription, DNA-dependent|RNA splicing|sprouting angiogenesis|transcription, DNA-dependent	nucleolus|nucleoplasm	histone demethylase activity (H3-R2 specific)|histone demethylase activity (H4-R3 specific)|identical protein binding|iron ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|peptidyl-lysine 5-dioxygenase activity|single-stranded RNA binding			endometrium(2)|kidney(5)|large_intestine(2)|lung(3)|ovary(2)|skin(2)	16						TTCCGGAGCGTGGTGGCCCCA	0.478000													14	89					0	0	0.557998	0	0
KLHL10	317719	broad.mit.edu	37	17	40001820	40001820	+	Missense_Mutation	SNP	G	G	A			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr17:40001820G>A	ENST00000293303.4	+	3	1280	c.1127G>A	c.(1126-1128)cGt>cAt	p.R376H		NM_152467.3	NP_689680.2	Q6JEL2	KLH10_HUMAN	kelch-like family member 10	376						cytoplasm				breast(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(5)|lung(7)|ovary(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	26		Breast(137;0.000162)				CACTCCAGACGTTGCTATGTC	0.463000													12	61					0	0	0.411799	0	0
OR5AC2	81050	broad.mit.edu	37	3	97806525	97806525	+	Missense_Mutation	SNP	T	T	A			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr3:97806525T>A	ENST00000358642.2	+	1	509	c.509T>A	c.(508-510)tTc>tAc	p.F170Y		NM_054106.1	NP_473447.1	Q9NZP5	O5AC2_HUMAN	olfactory receptor, family 5, subfamily AC, member 2	170					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(4)|large_intestine(3)|lung(13)|pancreas(1)|prostate(2)|skin(4)|urinary_tract(1)	28						CGACTAACTTTCTGCAGGTTT	0.333000													10	77					0	0	0.411799	0	0
OR1J4	26219	broad.mit.edu	37	9	125282004	125282004	+	Silent	SNP	T	T	C			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr9:125282004T>C	ENST00000340750.1	+	1	585	c.585T>C	c.(583-585)aaT>aaC	p.N195N		NM_001004452.1	NP_001004452.1	Q8NGS1	OR1J4_HUMAN	olfactory receptor, family 1, subfamily J, member 4	195					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(5)|lung(11)|skin(3)|upper_aerodigestive_tract(1)	20						TCTCCCTCAATGAGCTGGTCA	0.493000													6	42					0	0	0.248553	0	0
PUS7L	83448	broad.mit.edu	37	12	44124307	44124307	+	Missense_Mutation	SNP	C	C	A			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr12:44124307C>A	ENST00000416848.2	-	9	2466	c.1978G>T	c.(1978-1980)Gac>Tac	p.D660Y	PUS7L_ENST00000344862.5_Missense_Mutation_p.D660Y|PUS7L_ENST00000431332.3_Missense_Mutation_p.D347Y|PUS7L_ENST00000551923.1_Missense_Mutation_p.D660Y	NM_001098615.1|NM_001271826.1	NP_001092085.1|NP_001258755.1	Q9H0K6	PUS7L_HUMAN	pseudouridylate synthase 7 homolog (S. cerevisiae)-like	660					pseudouridine synthesis|tRNA processing		pseudouridine synthase activity|RNA binding			NS(1)|endometrium(1)|kidney(2)|large_intestine(9)|lung(15)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	32	all_cancers(12;0.00027)	Lung NSC(34;0.114)|all_lung(34;0.24)		GBM - Glioblastoma multiforme(48;0.0402)		ACATCAATGTCATGATCTTCC	0.368000													5	89					1.23904e-05	1.42058e-05	0.184627	1	0
OR6X1	390260	broad.mit.edu	37	11	123624360	123624360	+	Silent	SNP	A	A	T			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr11:123624360A>T	ENST00000327930.2	-	1	893	c.867T>A	c.(865-867)acT>acA	p.T289T		NM_001005188.1	NP_001005188.1	Q8NH79	OR6X1_HUMAN	olfactory receptor, family 6, subfamily X, member 1	289					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(3)|endometrium(3)|large_intestine(4)|lung(8)|ovary(2)|prostate(1)|skin(2)	23		Breast(109;0.0109)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0279)		TGTTTCTAATAGTATAAATAA	0.413000													18	90					0	0	0.592651	0	0
MKRN3	7681	broad.mit.edu	37	15	23811411	23811411	+	Missense_Mutation	SNP	C	C	G			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr15:23811411C>G	ENST00000314520.3	+	1	958	c.482C>G	c.(481-483)cCg>cGg	p.P161R	MKRN3_ENST00000564592.1_Intron|MKRN3_ENST00000568252.1_Intron	NM_005664.3	NP_005655.1	Q13064	MKRN3_HUMAN	makorin ring finger protein 3	161						ribonucleoprotein complex	ligase activity|nucleic acid binding|zinc ion binding			breast(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(33)|ovary(2)|prostate(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	61		all_cancers(20;8.44e-25)|all_epithelial(15;3.69e-22)|Lung NSC(15;2.96e-18)|all_lung(15;2.8e-17)|Breast(32;0.000353)|Colorectal(260;0.14)		all cancers(64;3.02e-06)|Epithelial(43;1.94e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0012)		GAAGCCCCCCCGGCTGCATCC	0.642000													7	37					0	0	0.248553	0	0
BTN2A3P	54718	broad.mit.edu	37	6	26428160	26428160	+	RNA	SNP	G	G	T			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr6:26428160G>T	ENST00000466808.2	+	0	1129																											TGATTATTCTGATGATACCCA	0.413000													22	70					1.10923e-09	1.39996e-09	0.639603	1	0
TCF7	6932	broad.mit.edu	37	5	133473755	133473755	+	Missense_Mutation	SNP	G	G	T			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr5:133473755G>T	ENST00000395029.1	+	4	642	c.447G>T	c.(445-447)aaG>aaT	p.K149N	TCF7_ENST00000378564.1_Missense_Mutation_p.K149N|TCF7_ENST00000321584.4_Missense_Mutation_p.K149N|TCF7_ENST00000342854.5_Missense_Mutation_p.K149N|TCF7_ENST00000520958.1_Missense_Mutation_p.K34N|TCF7_ENST00000321603.6_Missense_Mutation_p.K149N|TCF7_ENST00000378560.4_Missense_Mutation_p.K34N|TCF7_ENST00000518915.1_Missense_Mutation_p.K34N|TCF7_ENST00000395023.1_Missense_Mutation_p.K34N|TCF7_ENST00000432532.2_Missense_Mutation_p.K34N			P36402	TCF7_HUMAN	transcription factor 7 (T-cell specific, HMG-box)	149					cellular response to interleukin-4|immune response|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent|Wnt receptor signaling pathway	nucleus	protein binding|transcription regulatory region DNA binding			kidney(2)|large_intestine(7)|lung(2)|skin(1)	12		Breast(839;0.058)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			TTCAGCACAAGGCCAATCAGC	0.562000													13	152					1.37522e-17	1.87967e-17	0.557998	1	0
OR13C2	392376	broad.mit.edu	37	9	107367888	107367888	+	Silent	SNP	G	G	T			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr9:107367888G>T	ENST00000542196.1	-	1	63	c.21C>A	c.(19-21)acC>acA	p.T7T		NM_001004481.1	NP_001004481.1	Q8NGS9	O13C2_HUMAN	olfactory receptor, family 13, subfamily C, member 2	7					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(10)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	22						CCACCAGAATGGTGTGGTTTT	0.368000													7	41					0.000442599	0.000491254	0.335167	1	0
RARS2	57038	broad.mit.edu	37	6	88299660	88299660	+	Missense_Mutation	SNP	G	G	A			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr6:88299660G>A	ENST00000369536.5	-	1	61	c.16C>T	c.(16-18)Cgc>Tgc	p.R6C		NM_020320.3	NP_064716.2	Q5T160	SYRM_HUMAN	arginyl-tRNA synthetase 2, mitochondrial	6					arginyl-tRNA aminoacylation	mitochondrial matrix	arginine-tRNA ligase activity|ATP binding|protein binding	p.R6C(1)		breast(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(6)|lung(7)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	22		all_cancers(76;3.93e-06)|Acute lymphoblastic leukemia(125;3.55e-10)|Prostate(29;3.51e-09)|all_hematologic(105;3.29e-06)|all_epithelial(107;0.00575)		BRCA - Breast invasive adenocarcinoma(108;0.0456)		ATAGCGCGGCGAAAGCCGCAC	0.672000											OREG0031911	type=REGULATORY REGION|TFbs=RELA|Dataset=RELA (p65) ChIP-PET Binding Sites|EvidenceSubtype=Chromatin immunoprecipitation with paired-end diTag sequencing (ChIP-PET)	4	45					0	0	0.217242	0	0
MYO16	23026	broad.mit.edu	37	13	109613951	109613951	+	Missense_Mutation	SNP	C	C	T			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr13:109613951C>T	ENST00000356711.2	+	18	2162	c.2036C>T	c.(2035-2037)gCc>gTc	p.A679V	MYO16_ENST00000457511.2_Missense_Mutation_p.A191V|MYO16_ENST00000251041.5_Missense_Mutation_p.A679V|MYO16_ENST00000357550.2_Missense_Mutation_p.A679V	NM_015011.1	NP_055826.1	Q9Y6X6	MYO16_HUMAN	myosin XVI	679	Myosin head-like 1.				cerebellum development|negative regulation of cell proliferation|negative regulation of S phase of mitotic cell cycle	myosin complex|nucleoplasm|perinuclear region of cytoplasm|plasma membrane	actin filament binding|ATP binding|motor activity			NS(3)|breast(4)|central_nervous_system(2)|endometrium(10)|kidney(8)|large_intestine(27)|lung(51)|ovary(9)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	121	all_lung(23;0.000332)|all_neural(89;0.00294)|Medulloblastoma(90;0.00596)|Lung NSC(43;0.00751)|Lung SC(71;0.104)		BRCA - Breast invasive adenocarcinoma(86;0.19)|all cancers(43;0.201)			CGGTTTACTGCCCTGAATGAG	0.453000													10	65					0	0	0.387290	0	0
OR5D16	390144	broad.mit.edu	37	11	55606598	55606598	+	Missense_Mutation	SNP	A	A	T			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr11:55606598A>T	ENST00000378396.1	+	1	371	c.371A>T	c.(370-372)cAc>cTc	p.H124L		NM_001005496.1	NP_001005496.1	Q8NGK9	OR5DG_HUMAN	olfactory receptor, family 5, subfamily D, member 16	124					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|endometrium(2)|large_intestine(4)|lung(26)|ovary(5)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	44		all_epithelial(135;0.208)				GCCTATGACCACTTTGTGGCC	0.438000													23	82					0	0	0.654019	0	0
ITPR3	3710	broad.mit.edu	37	6	33632739	33632739	+	Missense_Mutation	SNP	G	G	T			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr6:33632739G>T	ENST00000374316.5	+	13	2301	c.1241G>T	c.(1240-1242)cGg>cTg	p.R414L	ITPR3_ENST00000605930.1_Missense_Mutation_p.R414L			Q14573	ITPR3_HUMAN	inositol 1,4,5-trisphosphate receptor, type 3	414	MIR 5.				activation of phospholipase C activity|calcium ion transport into cytosol|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|nerve growth factor receptor signaling pathway|platelet activation|protein heterooligomerization|protein homooligomerization|regulation of insulin secretion|response to calcium ion	apical part of cell|brush border|endoplasmic reticulum membrane|integral to plasma membrane|myelin sheath|neuronal cell body|nuclear outer membrane|platelet dense tubular network membrane	inositol 1,3,4,5 tetrakisphosphate binding|inositol 1,4,5 trisphosphate binding|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|inositol hexakisphosphate binding|intracellular ligand-gated calcium channel activity|protein binding			NS(1)|breast(6)|central_nervous_system(5)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|liver(1)|lung(24)|ovary(8)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	85						CGGCCCATCCGGCTCATGGTG	0.662000													14	34					1.5739e-10	2.01897e-10	0.500413	1	0
OR8K1	390157	broad.mit.edu	37	11	56114119	56114119	+	Missense_Mutation	SNP	A	A	G			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr11:56114119A>G	ENST00000279783.2	+	1	699	c.605A>G	c.(604-606)gAa>gGa	p.E202G		NM_001002907.1	NP_001002907.1	Q8NGG5	OR8K1_HUMAN	olfactory receptor, family 8, subfamily K, member 1	202					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(8)|liver(2)|lung(13)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	33	Esophageal squamous(21;0.00448)					AATGAATTAGAATTAATAATT	0.353000										HNSCC(65;0.19)			12	91					0	0	0.539581	0	0
NIPAL4	348938	broad.mit.edu	37	5	156898697	156898697	+	Missense_Mutation	SNP	G	G	A			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr5:156898697G>A	ENST00000311946.7	+	5	760	c.644G>A	c.(643-645)aGt>aAt	p.S215N	ADAM19_ENST00000430702.2_Intron|NIPAL4_ENST00000435489.2_Missense_Mutation_p.S196N	NM_001099287.1	NP_001092757.1	Q0D2K0	NIPA4_HUMAN	NIPA-like domain containing 4	215						integral to membrane	receptor activity			breast(3)|endometrium(3)|kidney(1)|large_intestine(1)|lung(12)|prostate(1)|skin(1)	22						CTGAGGGAGAGTCTGAACCTG	0.537000											OREG0016979	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	19					0	0	0.184627	0	0
SCNN1D	6339	broad.mit.edu	37	1	1225876	1225876	+	Silent	SNP	C	C	T			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr1:1225876C>T	ENST00000338555.2	+	11	2452	c.1308C>T	c.(1306-1308)ctC>ctT	p.L436L	SCNN1D_ENST00000379116.5_Silent_p.L600L|SCNN1D_ENST00000400928.3_Silent_p.L436L|SCNN1D_ENST00000325425.8_Silent_p.L502L					sodium channel, non-voltage-gated 1, delta subunit											lung(6)|skin(1)	7	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;3.01e-35)|OV - Ovarian serous cystadenocarcinoma(86;2.46e-21)|Colorectal(212;0.000157)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00229)|BRCA - Breast invasive adenocarcinoma(365;0.00251)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.034)|Lung(427;0.199)		TCTACCGCCTCTACCAGGACC	0.672000													8	120					0	0	0.335167	0	0
SERPINA6	866	broad.mit.edu	37	14	94776296	94776296	+	Missense_Mutation	SNP	A	A	T			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr14:94776296A>T	ENST00000341584.3	-	3	807	c.661T>A	c.(661-663)Ttc>Atc	p.F221I		NM_001756.3	NP_001747.2	P08185	CBG_HUMAN	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6	221					regulation of proteolysis|transport	extracellular space	serine-type endopeptidase inhibitor activity|steroid binding			central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(11)|ovary(1)|skin(4)|upper_aerodigestive_tract(1)	26		all_cancers(154;0.0482)|all_epithelial(191;0.166)		COAD - Colon adenocarcinoma(157;0.211)	Alclometasone(DB00240)|Beclomethasone(DB00394)|Ciclesonide(DB01410)|Flumethasone Pivalate(DB00663)|Flunisolide(DB00180)|Fluocinolone Acetonide(DB00591)|Fluocinonide(DB01047)|Fluorometholone(DB00324)|Flurandrenolide(DB00846)|Fluticasone Propionate(DB00588)|Halobetasol Propionate(DB00596)|Medrysone(DB00253)|Mitotane(DB00648)|Paramethasone(DB01384)|Prednisolone(DB00860)|Rimexolone(DB00896)|Triamcinolone(DB00620)	TCCACATAGAAGTTCTCCTCC	0.552000													4	34					0	0	0.184627	0	0
EPPK1	83481	broad.mit.edu	37	8	144945228	144945228	+	Missense_Mutation	SNP	G	G	A			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr8:144945228G>A	ENST00000525985.1	-	2	2265	c.2194C>T	c.(2194-2196)Ccc>Tcc	p.P732S				P58107	EPIPL_HUMAN	epiplakin 1	732						cytoplasm|cytoskeleton	protein binding|structural molecule activity			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(5)|cervix(1)|endometrium(8)|kidney(4)|large_intestine(2)|lung(30)|ovary(2)|pancreas(1)|prostate(10)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	71	all_cancers(97;1.42e-10)|all_epithelial(106;1.99e-09)|Lung NSC(106;0.000126)|all_lung(105;0.000354)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;2.88e-40)|all cancers(56;1.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			CTGTGCACGGGGTCGATGACG	0.652000													7	86					0	0	0.248553	0	0
EPX	8288	broad.mit.edu	37	17	56272480	56272480	+	Silent	SNP	C	C	T			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr17:56272480C>T	ENST00000225371.5	+	6	860	c.750C>T	c.(748-750)ggC>ggT	p.G250G		NM_000502.4	NP_000493.1	P11678	PERE_HUMAN	eosinophil peroxidase	250					hydrogen peroxide catabolic process		heme binding|peroxidase activity|protein binding			breast(2)|endometrium(9)|kidney(1)|large_intestine(9)|liver(2)|lung(20)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)	48						TCACTGCAGGCGTTGACTGTG	0.622000													9	106					0	0	0.387290	0	0
TSIX	9383	broad.mit.edu	37	X	73046437	73046437	+	RNA	SNP	A	A	T			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chrX:73046437A>T	ENST00000604411.1	+	0	34398				XIST_ENST00000429829.1_lincRNA	NR_003255.2																						AATATCTAAGAGTAAGAAGTG	0.393000													22	101					0	0	0.667858	0	0
ZNF557	79230	broad.mit.edu	37	19	7083170	7083170	+	Silent	SNP	C	C	T			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr19:7083170C>T	ENST00000414706.1	+	8	1181	c.708C>T	c.(706-708)taC>taT	p.Y236Y	ZNF557_ENST00000439035.2_Silent_p.Y229Y|ZNF557_ENST00000252840.6_Silent_p.Y236Y	NM_001044387.1|NM_001044388.1|NM_024341.2	NP_001037852.1|NP_001037853.1|NP_077317.2	Q8N988	ZN557_HUMAN	zinc finger protein 557	229					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(6)|large_intestine(1)|lung(5)|ovary(1)|pancreas(1)|skin(1)|stomach(1)|urinary_tract(1)	17				Lung(535;0.179)		AGAAACCCTACGAATGCAGTG	0.443000													3	40					0	0	0.115264	0	0
ZFAND2A	90637	broad.mit.edu	37	7	1195212	1195212	+	Silent	SNP	G	G	A			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr7:1195212G>A	ENST00000401903.1	-	4	418	c.159C>T	c.(157-159)caC>caT	p.H53H	ZFAND2A_ENST00000316495.3_Silent_p.H53H			Q8N6M9	ZFN2A_HUMAN	zinc finger, AN1-type domain 2A	53			H -> L (in dbSNP:rs17855544).			cytoplasm|nucleus	zinc ion binding			lung(2)|ovary(1)	3		Ovarian(82;0.11)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0178)|OV - Ovarian serous cystadenocarcinoma(56;1.82e-15)		ATACTGGGACGTGAACATCCT	0.448000													11	84					0	0	0.411799	0	0
ZNF736	728927	broad.mit.edu	37	7	63809421	63809421	+	Missense_Mutation	SNP	G	G	C			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr7:63809421G>C	ENST00000355095.4	+	5	1502	c.1180G>C	c.(1180-1182)Gag>Cag	p.E394Q	ZNF736_ENST00000423484.1_Missense_Mutation_p.E394Q	NM_001170905.1	NP_001164376.1	B4DX44	ZN736_HUMAN	zinc finger protein 736	394					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(6)|stomach(1)|urinary_tract(1)	9						TCACACTGGAGAGAAACCCTA	0.408000													3	18					0	0	0.115264	0	0
TSHZ2	128553	broad.mit.edu	37	20	51872726	51872726	+	Missense_Mutation	SNP	C	C	T			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr20:51872726C>T	ENST00000371497.5	+	2	3616	c.2729C>T	c.(2728-2730)aCg>aTg	p.T910M	RP4-678D15.1_ENST00000606932.1_RNA|TSHZ2_ENST00000603338.2_Missense_Mutation_p.T907M|TSHZ2_ENST00000329613.6_Missense_Mutation_p.T907M	NM_001193421.1|NM_173485.5	NP_001180350.1|NP_775756.3	Q9NRE2	TSH2_HUMAN	teashirt zinc finger homeobox 2	910					multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(2)|breast(4)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(16)|lung(38)|ovary(5)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	84			STAD - Stomach adenocarcinoma(23;0.1)			CTTAGGAAAACGGGCGGGACA	0.488000													6	93					0	0	0.278610	0	0
MFSD1	64747	broad.mit.edu	37	3	158531837	158531837	+	Silent	SNP	C	C	T	rs147447476		TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr3:158531837C>T	ENST00000415822.2	+	7	921	c.780C>T	c.(778-780)ctC>ctT	p.L260L	MFSD1_ENST00000392813.4_Silent_p.L221L|MFSD1_ENST00000264266.8_Silent_p.L211L	NM_022736.2	NP_073573.2	Q9H3U5	MFSD1_HUMAN	major facilitator superfamily domain containing 1	211					transmembrane transport	integral to membrane				breast(1)|central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(3)|lung(15)|skin(1)	26			Lung(72;0.00372)|LUSC - Lung squamous cell carcinoma(72;0.00523)			ACACAACCCTCGGGATCACAC	0.453000													6	49					0	0	0.248553	0	0
TTC7B	145567	broad.mit.edu	37	14	91282527	91282527	+	Missense_Mutation	SNP	A	A	G			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr14:91282527A>G	ENST00000357056.2	-	1	234	c.113T>C	c.(112-114)aTc>aCc	p.I38T	TTC7B_ENST00000328459.6_Missense_Mutation_p.I38T			Q86TV6	TTC7B_HUMAN	tetratricopeptide repeat domain 7B	38							binding			NS(1)|breast(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(8)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)	36		Melanoma(154;0.222)				ACCGTTGGCGATGAGCTTGGC	0.776000													5	25					0	0	0.217242	0	0
TRIM28	10155	broad.mit.edu	37	19	59060353	59060353	+	Splice_Site	SNP	A	A	G	rs111246927		TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr19:59060353A>G	ENST00000253024.5	+	12	1698		c.e12-1		TRIM28_ENST00000341753.6_Splice_Site	NM_005762.2	NP_005753.1	Q13263	TIF1B_HUMAN	tripartite motif containing 28						epithelial to mesenchymal transition|positive regulation of transcription, DNA-dependent	nucleoplasm	chromo shadow domain binding|ligase activity|transcription corepressor activity|zinc ion binding			biliary_tract(1)|breast(2)|endometrium(2)|kidney(2)|large_intestine(3)|lung(7)|ovary(1)|urinary_tract(1)	19		all_cancers(17;4.4e-22)|all_epithelial(17;2.15e-16)|Lung NSC(17;1.24e-06)|all_lung(17;5.41e-06)|Colorectal(82;3.46e-05)|Renal(17;0.00179)|all_neural(62;0.00607)|Ovarian(87;0.0443)|Breast(46;0.0928)|Medulloblastoma(540;0.184)		UCEC - Uterine corpus endometrioid carcinoma (67;0.0434)|all cancers(4;1.39e-13)|Epithelial(4;1.01e-10)|OV - Ovarian serous cystadenocarcinoma(4;2.34e-09)|GBM - Glioblastoma multiforme(193;0.0102)|Lung(386;0.179)		CTGCATCTACAGGTCCCGCTC	0.622000													3	39					0	0	0.115264	0	0
MARCH9	92979	broad.mit.edu	37	12	58150755	58150755	+	Missense_Mutation	SNP	G	G	A			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr12:58150755G>A	ENST00000266643.5	+	2	832	c.401G>A	c.(400-402)tGc>tAc	p.C134Y		NM_138396.5	NP_612405.2	Q86YJ5	MARH9_HUMAN	membrane-associated ring finger (C3HC4) 9	134						Golgi membrane|Golgi stack|integral to membrane|lysosomal membrane|trans-Golgi network	ligase activity|zinc ion binding			autonomic_ganglia(1)|large_intestine(2)|lung(1)	4	all_cancers(7;4.96e-69)|Lung NSC(6;5.5e-25)|all_lung(6;3.87e-23)|all_epithelial(6;1.66e-15)|Glioma(12;6.95e-05)|all_neural(12;0.00016)|Melanoma(17;0.122)		GBM - Glioblastoma multiforme(5;4.21e-120)|all cancers(5;3.75e-83)|BRCA - Breast invasive adenocarcinoma(9;0.0294)			TCAGTGCGCTGCACGCATCAG	0.647000											OREG0021952	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	3	30					0	0	0.150653	0	0
BTLA	151888	broad.mit.edu	37	3	112198407	112198407	+	Missense_Mutation	SNP	G	G	C			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr3:112198407G>C	ENST00000334529.5	-	2	500	c.298C>G	c.(298-300)Cta>Gta	p.L100V	BTLA_ENST00000383680.4_Missense_Mutation_p.L100V	NM_181780.3	NP_861445.3	Q7Z6A9	BTLA_HUMAN	B and T lymphocyte associated	100	Ig-like V-type.				T cell costimulation		receptor activity			breast(1)|central_nervous_system(1)|cervix(2)|large_intestine(1)|lung(5)|prostate(1)	11		Acute lymphoblastic leukemia(4;1.34e-07)|all_hematologic(4;0.000361)				TCAAAATGTAGAATGAAAAAT	0.378000													7	74					0	0	0.278610	0	0
TRIM41	90933	broad.mit.edu	37	5	180661251	180661251	+	Missense_Mutation	SNP	G	G	C			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr5:180661251G>C	ENST00000315073.5	+	6	2079	c.1369G>C	c.(1369-1371)Gag>Cag	p.E457Q	TRIM41_ENST00000351937.5_Missense_Mutation_p.E457Q|TRIM41_ENST00000510072.1_3'UTR	NM_033549.4	NP_291027.3	Q8WV44	TRI41_HUMAN	tripartite motif containing 41	457	B30.2/SPRY.					cytoplasm|nucleus	ligase activity|protein binding|zinc ion binding			NS(1)|endometrium(4)|kidney(2)|large_intestine(7)|lung(3)|prostate(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	26	all_cancers(89;9.17e-06)|all_epithelial(37;1.19e-06)|Renal(175;0.000159)|Lung NSC(126;0.00354)|all_lung(126;0.00609)|Breast(19;0.0684)	all_cancers(40;0.000209)|Medulloblastoma(196;0.0133)|all_neural(177;0.0199)|all_lung(500;0.0221)|all_hematologic(541;0.0433)|Lung NSC(249;0.132)|Ovarian(839;0.238)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CCGCCTGGCAGAGCGGCGGCA	0.697000													4	85					0	0	0.248553	0	0
SCN7A	6332	broad.mit.edu	37	2	167298209	167298209	+	Nonsense_Mutation	SNP	C	C	T			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr2:167298209C>T	ENST00000409855.1	-	14	1980	c.1854G>A	c.(1852-1854)tgG>tgA	p.W618*		NM_002976.3	NP_002967.2	Q01118	SCN7A_HUMAN	sodium channel, voltage-gated, type VII, alpha subunit	618					muscle contraction	voltage-gated sodium channel complex	voltage-gated sodium channel activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(1)|lung(30)|prostate(4)|soft_tissue(1)|urinary_tract(1)	44						TACTAAGAGACCACATCAAAA	0.373000													20	49					0	0	0.654019	0	0
CT47B1	643311	broad.mit.edu	37	X	120008755	120008755	+	Missense_Mutation	SNP	G	G	T			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chrX:120008755G>T	ENST00000371311.3	-	1	1024	c.770C>A	c.(769-771)cCc>cAc	p.P257H		NM_001145718.1	NP_001139190.1	P0C2W7	CT47B_HUMAN	cancer/testis antigen family 47, member B1	257										breast(1)|central_nervous_system(1)|endometrium(7)|kidney(2)|lung(9)|ovary(1)|skin(1)	22						CTTACCCTCGGGGGCCACGGC	0.682000													17	110					1.55795e-14	2.05754e-14	0.608945	1	0
TENM1	10178	broad.mit.edu	37	X	123519792	123519792	+	Silent	SNP	C	C	A			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chrX:123519792C>A	ENST00000422452.2	-	29	5874	c.5811G>T	c.(5809-5811)gtG>gtT	p.V1937V	TENM1_ENST00000371130.3_Silent_p.V1930V|STAG2_ENST00000469481.1_Intron	NM_001163278.1|NM_001163279.1	NP_001156750.1|NP_001156751.1			teneurin transmembrane protein 1																		GGTAGTAGCCCACTGAAAGCA	0.512000													22	95					4.7796e-09	5.96022e-09	0.681144	1	0
RXFP1	59350	broad.mit.edu	37	4	159559173	159559173	+	Missense_Mutation	SNP	A	A	T			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr4:159559173A>T	ENST00000307765.5	+	13	1236	c.985A>T	c.(985-987)Aat>Tat	p.N329Y	RXFP1_ENST00000343542.5_Intron|RXFP1_ENST00000470033.1_Missense_Mutation_p.N296Y|RXFP1_ENST00000448688.2_Missense_Mutation_p.N224Y|RXFP1_ENST00000460056.2_Missense_Mutation_p.N248Y	NM_001253727.1|NM_001253728.1|NM_001253730.1|NM_001253732.1|NM_001253733.1|NM_021634.3	NP_001240656.1|NP_001240657.1|NP_001240659.1|NP_001240661.1|NP_001240662.1|NP_067647.2	Q9HBX9	RXFP1_HUMAN	relaxin/insulin-like family peptide receptor 1	329						integral to membrane|plasma membrane	G-protein coupled receptor activity|metal ion binding			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(5)|liver(2)|lung(22)|prostate(1)|skin(10)	49	all_hematologic(180;0.24)	Renal(120;0.0854)		COAD - Colon adenocarcinoma(41;0.0219)		TCTTTCCTATAATCCAATCCA	0.299000													5	34					0	0	0.217242	0	0
PDZD2	23037	broad.mit.edu	37	5	32088396	32088396	+	Silent	SNP	T	T	C			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr5:32088396T>C	ENST00000438447.1	+	20	5230	c.4842T>C	c.(4840-4842)ccT>ccC	p.P1614P	PDZD2_ENST00000282493.3_Silent_p.P1614P			O15018	PDZD2_HUMAN	PDZ domain containing 2	1614					cell adhesion	cell-cell junction|endoplasmic reticulum|extracellular region|nucleus				NS(2)|breast(4)|central_nervous_system(5)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(31)|lung(58)|ovary(6)|prostate(2)|skin(8)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	148						CCTCGAGTCCTGCTCATCTTC	0.542000													63	217					0	0	0.870114	0	0
GTF2IRD2P1	401375	broad.mit.edu	37	7	72658162	72658162	+	RNA	SNP	C	C	A			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr7:72658162C>A	ENST00000425256.1	-	0	1749					NR_002164.1																						tcttcaacttctgagcacaga	0.502000													11	55					1.49906e-05	1.71243e-05	0.457914	1	0
ZFAND6	54469	broad.mit.edu	37	15	80415143	80415143	+	Splice_Site	SNP	G	G	A			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr15:80415143G>A	ENST00000261749.6	+	5	786		c.e5+1		ZFAND6_ENST00000558494.1_Splice_Site|ZFAND6_ENST00000559775.1_Splice_Site|ZFAND6_ENST00000561060.1_Splice_Site|ZFAND6_ENST00000559157.1_Splice_Site|ZFAND6_ENST00000558087.1_Splice_Site|ZFAND6_ENST00000558688.1_Splice_Site|ZFAND6_ENST00000559835.1_Splice_Site	NM_001242913.1|NM_001242914.1|NM_019006.3	NP_001229842.1|NP_001229843.1|NP_061879.2	Q6FIF0	ZFAN6_HUMAN	zinc finger, AN1-type domain 6								DNA binding|zinc ion binding			cervix(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(5)|ovary(1)	11						GATGTGCAGGGTTTGTATATG	0.358000													9	49					0	0	0.307466	0	0
PCDH15	65217	broad.mit.edu	37	10	55582031	55582031	+	Missense_Mutation	SNP	G	G	T			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr10:55582031G>T	ENST00000361849.3	-	34	5855	c.5461C>A	c.(5461-5463)Cct>Act	p.P1821T	PCDH15_ENST00000414778.1_Intron|PCDH15_ENST00000395446.1_Intron|PCDH15_ENST00000409834.1_Intron|PCDH15_ENST00000437009.1_Missense_Mutation_p.P1750T|PCDH15_ENST00000395433.1_Missense_Mutation_p.P1796T|PCDH15_ENST00000395440.1_Intron|PCDH15_ENST00000373965.2_Intron|PCDH15_ENST00000395445.1_Intron|PCDH15_ENST00000463095.1_5'UTR|PCDH15_ENST00000395442.1_Intron|PCDH15_ENST00000373957.3_Intron|PCDH15_ENST00000395432.2_Missense_Mutation_p.P1779T|PCDH15_ENST00000320301.6_Missense_Mutation_p.P1819T|PCDH15_ENST00000395438.1_Intron|PCDH15_ENST00000395430.1_Missense_Mutation_p.P1816T	NM_001142763.1|NM_001142764.1|NM_001142765.1|NM_001142768.1	NP_001136235.1|NP_001136236.1|NP_001136237.1|NP_001136240.1	Q96QU1	PCD15_HUMAN	protocadherin-related 15	1819	Poly-Pro.				equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			NS(3)|breast(6)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(39)|lung(108)|ovary(5)|pancreas(6)|prostate(6)|skin(12)|upper_aerodigestive_tract(12)|urinary_tract(1)	237		Melanoma(3;0.117)|Lung SC(717;0.238)				ggtggtggaggaagaggagtt	0.483000										HNSCC(58;0.16)			3	22					0.115264	0.118287	0.115264	1	0
OR8J3	81168	broad.mit.edu	37	11	55904768	55904768	+	Missense_Mutation	SNP	G	G	T			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr11:55904768G>T	ENST00000301529.1	-	1	426	c.427C>A	c.(427-429)Ctg>Atg	p.L143M		NM_001004064.1	NP_001004064.1	Q8NGG0	OR8J3_HUMAN	olfactory receptor, family 8, subfamily J, member 3	143					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(1)|lung(38)|pancreas(1)|prostate(1)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)	59	Esophageal squamous(21;0.00693)					GACACCAGCAGGAGGCAGAGC	0.473000													5	77					3.59834e-05	4.03684e-05	0.217242	1	0
HORMAD1	84072	broad.mit.edu	37	1	150691947	150691947	+	Splice_Site	SNP	A	A	C			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr1:150691947A>C	ENST00000368993.2	-	2	139		c.e2+1		HORMAD1_ENST00000368995.4_Splice_Site|HORMAD1_ENST00000322343.7_Splice_Site|HORMAD1_ENST00000361824.2_Splice_Site|HORMAD1_ENST00000476530.1_Splice_Site			Q86X24	HORM1_HUMAN	HORMA domain containing 1						blastocyst development|cell differentiation|meiotic DNA double-strand break formation|meiotic recombination checkpoint|meiotic sister chromatid cohesion|mitosis|oogenesis|regulation of homologous chromosome segregation|spermatogenesis|synaptonemal complex assembly	chromosome|nucleus				breast(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|large_intestine(3)|lung(4)|ovary(3)	16	all_cancers(9;3.23e-52)|all_epithelial(9;4.68e-43)|all_lung(15;5.74e-35)|Lung NSC(24;2.09e-31)|Breast(34;0.0009)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Melanoma(130;0.128)|Colorectal(459;0.171)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0241)|Epithelial(6;2.32e-23)|all cancers(9;5.21e-23)|OV - Ovarian serous cystadenocarcinoma(6;6.72e-15)|BRCA - Breast invasive adenocarcinoma(12;0.000479)|LUSC - Lung squamous cell carcinoma(543;0.171)			AAGAAATCATACCATGGGAGT	0.363000													14	52					0	0	0.557998	0	0
WDTC1	23038	broad.mit.edu	37	1	27632808	27632809	+	Frame_Shift_Ins	INS	-	-	G			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr1:27632808_27632809insG	ENST00000319394.3	+	16	2503_2504	c.1968_1969insG	c.(1966-1971)agggggfs	p.RG656fs	WDTC1_ENST00000361771.3_Frame_Shift_Ins_p.RG655fs	NM_001276252.1|NM_015023.3	NP_001263181.1|NP_055838.2	Q8N5D0	WDTC1_HUMAN	WD and tetratricopeptide repeats 1	656							protein binding			central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(7)|lung(5)|ovary(1)|skin(1)	21		all_cancers(24;3.12e-19)|all_epithelial(13;4.18e-18)|Colorectal(325;0.000147)|all_lung(284;0.000366)|Lung NSC(340;0.000548)|Renal(390;0.00211)|Breast(348;0.00257)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0707)|all_neural(195;0.0966)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0443)|OV - Ovarian serous cystadenocarcinoma(117;1.09e-27)|Colorectal(126;8.83e-09)|COAD - Colon adenocarcinoma(152;1.02e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000544)|KIRC - Kidney renal clear cell carcinoma(1967;0.00201)|STAD - Stomach adenocarcinoma(196;0.00321)|READ - Rectum adenocarcinoma(331;0.0476)		GCCTGAGCAGTGGGGGTGCCGG	0.649													16	96	---	---	---	---					
RFX5	5993	broad.mit.edu	37	1	151316295	151316295	+	Frame_Shift_Del	DEL	G	G	-			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr1:151316295delG	ENST00000290524.4	-	9	797	c.619delC	c.(619-621)tgfs	p.L207fs	RFX5_ENST00000368870.2_Frame_Shift_Del_p.L207fs|RFX5_ENST00000452671.2_Frame_Shift_Del_p.L207fs|RFX5_ENST00000452513.2_Frame_Shift_Del_p.L167fs	NM_000449.3|NM_001025603.1	NP_000440.1|NP_001020774.1	P48382	RFX5_HUMAN	regulatory factor X, 5 (influences HLA class II expression)	207						nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			endometrium(3)|kidney(2)|large_intestine(2)|lung(9)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	20	Lung SC(34;0.00471)|Ovarian(49;0.0147)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)			TCACAGGTCAGGGCACACGCT	0.577													17	177	---	---	---	---					
SYN2	6854	broad.mit.edu	37	3	12046124	12046126	+	RNA	DEL	AGC	AGC	-	rs76272937		TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr3:12046124_12046126delAGC	ENST00000432424.2	+	0	245_247							Q86VA8	Q86VA8_HUMAN	synapsin II						neurotransmitter secretion	synaptic vesicle	ATP binding|ligase activity			breast(5)|central_nervous_system(1)|endometrium(1)|large_intestine(5)|lung(5)|ovary(1)	18						AGCCCCAGCAAGCGCCGAcgccg	0.764													2	4	---	---	---	---					
LARP1	23367	broad.mit.edu	37	5	154181822	154181822	+	Frame_Shift_Del	DEL	G	G	-			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr5:154181822delG	ENST00000336314.4	+	11	1765	c.1741delG	c.(1741-1743)ggfs	p.G582fs		NM_015315.3	NP_056130.2	Q6PKG0	LARP1_HUMAN	La ribonucleoprotein domain family, member 1	659							protein binding|RNA binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(10)|lung(9)|ovary(3)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	33	Renal(175;0.00488)	Medulloblastoma(196;0.0354)|all_neural(177;0.147)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)			CCGGCACCCAGGGGGGGACCG	0.547													7	133	---	---	---	---					
TP53INP1	94241	broad.mit.edu	37	8	95952409	95952411	+	In_Frame_Del	DEL	TCT	TCT	-			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr8:95952409_95952411delTCT	ENST00000342697.4	-	3	557_559	c.150_152delAGA	c.(148-153)gag>ga	p.EE50del	TP53INP1_ENST00000448464.2_In_Frame_Del_p.EE50del|TP53INP1_ENST00000378776.4_In_Frame_Del_p.EE50del|NDUFAF6_ENST00000396113.1_Intron	NM_033285.3	NP_150601.1	Q96A56	T53I1_HUMAN	tumor protein p53 inducible nuclear protein 1	50	Glu-rich.				apoptosis	PML body		p.E50E(1)		kidney(2)|large_intestine(3)|lung(2)|prostate(1)|skin(1)	9	Breast(36;8.75e-07)					GATGTCCTCCTCTTCTTCTTCTT	0.458													9	56	---	---	---	---					
NOX5	79400	broad.mit.edu	37	15	69339827	69339828	+	Frame_Shift_Ins	INS	-	-	G			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr15:69339827_69339828insG	ENST00000260364.5	+	13	2014_2015	c.1713_1714insG	c.(1711-1716)gcgcatfs	p.H572fs	NOX5_ENST00000388866.3_Frame_Shift_Ins_p.H590fs|NOX5_ENST00000525163.1_3'UTR|NOX5_ENST00000448182.3_Frame_Shift_Ins_p.H544fs|NOX5_ENST00000530406.2_Frame_Shift_Ins_p.H562fs|NOX5_ENST00000455873.3_Frame_Shift_Ins_p.H555fs			Q96PH1	NOX5_HUMAN	NADPH oxidase, EF-hand calcium binding domain 5	590	FAD-binding FR-type.				angiogenesis|cytokine secretion|cytokinesis|electron transport chain|endothelial cell proliferation|induction of apoptosis|positive regulation of reactive oxygen species metabolic process|regulation of fusion of sperm to egg plasma membrane|regulation of proton transport|superoxide anion generation	endoplasmic reticulum|integral to membrane	calcium ion binding|electron carrier activity|flavin adenine dinucleotide binding|heme binding|hydrogen ion channel activity|NADP binding|superoxide-generating NADPH oxidase activity			breast(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|liver(2)|lung(18)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	35						TCATCGGGGCAGGCATCGGCAT	0.589													8	99	---	---	---	---					
NUMBL	9253	broad.mit.edu	37	19	41173875	41173877	+	In_Frame_Del	DEL	TGC	TGC	-			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr19:41173875_41173877delTGC	ENST00000252891.4	-	10	1493_1495	c.1326_1328delGCA	c.(1324-1329)caa>ca	p.QQ444del	NUMBL_ENST00000540131.1_In_Frame_Del_p.QQ403del|NUMBL_ENST00000598779.1_In_Frame_Del_p.QQ403del	NM_004756.3	NP_004747.1	Q9Y6R0	NUMBL_HUMAN	numb homolog (Drosophila)-like	444	Poly-Gln.				cytokine-mediated signaling pathway|lateral ventricle development|neuroblast division in subventricular zone|protein metabolic process	cytoplasm	protein binding			NS(1)|breast(1)|endometrium(1)|large_intestine(5)|lung(6)|ovary(2)	16			Lung(22;0.000393)|LUSC - Lung squamous cell carcinoma(20;0.00105)			ttgctgctgttgctgctgctgct	0.660													3	4	---	---	---	---					
LIPE-AS1	100996307	broad.mit.edu	37	19	43136057	43136057	+	RNA	DEL	T	T	-			TCGA-86-7954-01A-11D-2184-08	TCGA-86-7954-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e9b59dff-cdd4-4c46-961a-b3fc4a1b1920	c2315104-b35e-48ad-91c2-f2f42deb5e5e	g.chr19:43136057delT	ENST00000594688.1	+	0	1450				LIPE-AS1_ENST00000594624.2_RNA	NR_073179.1																						AGTTACTTCATTGTGTATTAC	0.478													2	4	---	---	---	---