Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
ZNF141	7700	broad.mit.edu	37	4	366543	366543	+	Missense_Mutation	SNP	G	G	C			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr4:366543G>C	ENST00000240499.7	+	4	466	c.317G>C	c.(316-318)tGt>tCt	p.C106S	ZNF141_ENST00000505939.1_Intron|ZNF141_ENST00000512994.1_Missense_Mutation_p.C106S	NM_003441.2	NP_003432.1	Q15928	ZN141_HUMAN	zinc finger protein 141	106					anatomical structure morphogenesis|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleus	DNA binding|zinc ion binding			breast(1)|kidney(3)|large_intestine(5)|lung(8)|upper_aerodigestive_tract(1)	18						TATGAGAAATGTGGACATGAT	0.348000													5	44					0	0	1	0	0
LCA5	167691	broad.mit.edu	37	6	80201433	80201433	+	Missense_Mutation	SNP	C	C	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr6:80201433C>A	ENST00000392959.1	-	7	1581	c.970G>T	c.(970-972)Gat>Tat	p.D324Y	LCA5_ENST00000369846.4_Missense_Mutation_p.D324Y|LCA5_ENST00000467898.2_Missense_Mutation_p.D324Y	NM_181714.3	NP_859065.2	Q86VQ0	LCA5_HUMAN	Leber congenital amaurosis 5	324					protein transport	cilium axoneme|microtubule basal body	protein binding	p.D324N(1)		haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(11)|lung(15)|prostate(2)|skin(1)	32		all_cancers(76;3.32e-05)|Acute lymphoblastic leukemia(125;1.1e-05)|all_hematologic(105;0.00117)|all_epithelial(107;0.0176)		BRCA - Breast invasive adenocarcinoma(397;0.0657)		TCTGCAAAATCACTCTGGCAT	0.313000													21	104					1.2644e-06	1.49844e-06	1	1	0
DNAH5	1767	broad.mit.edu	37	5	13735298	13735298	+	Silent	SNP	T	T	A	rs139044537		TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr5:13735298T>A	ENST00000265104.4	-	68	11807	c.11703A>T	c.(11701-11703)ctA>ctT	p.L3901L		NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	3901					microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					TGTCAATCTTTAGGGTAAGCA	0.438000									Kartagener syndrome				40	66					0	0	1	0	0
CEP85	64793	broad.mit.edu	37	1	26586262	26586262	+	Missense_Mutation	SNP	A	A	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr1:26586262A>T	ENST00000252992.4	+	7	1441	c.1310A>T	c.(1309-1311)cAt>cTt	p.H437L	CEP85_ENST00000451429.2_Missense_Mutation_p.H386L	NM_022778.2	NP_073615.2	Q6P2H3	CEP85_HUMAN	centrosomal protein 85kDa	437						centrosome|nucleolus|spindle pole				breast(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(4)|lung(11)|skin(2)	25						TTGCAGAAGCATTCTGAGGAA	0.463000													33	58					0	0	1	0	0
CSMD3	114788	broad.mit.edu	37	8	113304867	113304867	+	Missense_Mutation	SNP	A	A	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr8:113304867A>T	ENST00000297405.5	-	55	8931	c.8687T>A	c.(8686-8688)gTg>gAg	p.V2896E	CSMD3_ENST00000352409.3_Missense_Mutation_p.V2826E|CSMD3_ENST00000343508.3_Missense_Mutation_p.V2856E|CSMD3_ENST00000455883.2_Missense_Mutation_p.V2727E	NM_198123.1	NP_937756.1	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3	2896	Sushi 19.					integral to membrane|plasma membrane				breast(7)|central_nervous_system(6)|endometrium(44)|haematopoietic_and_lymphoid_tissue(8)|kidney(36)|large_intestine(72)|liver(5)|lung(389)|ovary(24)|prostate(6)|skin(23)|upper_aerodigestive_tract(19)|urinary_tract(7)	646						GAATGTTACCACATCATTAAA	0.463000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			10	82					0	0	1	0	0
ATL3	25923	broad.mit.edu	37	11	63396867	63396867	+	Missense_Mutation	SNP	T	T	C	rs142132706	by1000genomes	TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr11:63396867T>C	ENST00000398868.3	-	13	1826	c.1550A>G	c.(1549-1551)cAt>cGt	p.H517R	ATL3_ENST00000332645.4_Missense_Mutation_p.H544R|ATL3_ENST00000538786.1_Missense_Mutation_p.H499R	NM_015459.3	NP_056274.3	Q6DD88	ATLA3_HUMAN	atlastin GTPase 3	517					endoplasmic reticulum organization|Golgi organization|protein homooligomerization	endoplasmic reticulum membrane|integral to membrane	GTP binding|GTPase activity|identical protein binding			endometrium(1)|large_intestine(3)|lung(2)|ovary(1)|pancreas(1)|skin(1)|stomach(1)|urinary_tract(1)	11						ATTACCGATATGAGAAGAAGC	0.368000													8	51					0	0	1	0	0
NPAS2	4862	broad.mit.edu	37	2	101582158	101582158	+	Silent	SNP	G	G	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr2:101582158G>T	ENST00000335681.5	+	10	1122	c.837G>T	c.(835-837)gtG>gtT	p.V279V	NPAS2_ENST00000542504.1_Silent_p.V344V	NM_002518.3	NP_002509.2	Q99743	NPAS2_HUMAN	neuronal PAS domain protein 2	279	PAS 2.				central nervous system development|positive regulation of transcription from RNA polymerase II promoter|rhythmic process	transcription factor complex	DNA binding|Hsp90 protein binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			cervix(1)|endometrium(3)|large_intestine(7)|lung(9)|ovary(3)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29						CTTTTGAAGTGCTGGGAACCT	0.577000													14	114					3.27435e-08	4.10752e-08	1	1	0
MAB21L1	4081	broad.mit.edu	37	13	36049841	36049841	+	Silent	SNP	G	G	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr13:36049841G>A	ENST00000379919.4	-	1	991	c.435C>T	c.(433-435)taC>taT	p.Y145Y	NBEA_ENST00000540320.1_Intron|NBEA_ENST00000310336.4_Intron|NBEA_ENST00000379939.2_Intron|NBEA_ENST00000400445.3_Intron	NM_005584.4	NP_005575.1	Q13394	MB211_HUMAN	mab-21-like 1 (C. elegans)	145					anatomical structure morphogenesis	nucleus				breast(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(7)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	20		Breast(139;0.014)|Lung SC(185;0.051)|Prostate(109;0.202)		all cancers(112;9.63e-08)|Epithelial(112;1.37e-06)|BRCA - Breast invasive adenocarcinoma(63;0.000659)|OV - Ovarian serous cystadenocarcinoma(117;0.00372)|GBM - Glioblastoma multiforme(144;0.115)		CCACATCCCGGTAGCTACATT	0.552000													22	36					0	0	1	0	0
OR5AP2	338675	broad.mit.edu	37	11	56409484	56409484	+	Silent	SNP	C	C	A	rs144441226		TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr11:56409484C>A	ENST00000544374.1	-	1	463	c.435G>T	c.(433-435)ggG>ggT	p.G145G	OR5AP2_ENST00000302981.1_Silent_p.G144G			Q8NGF4	O5AP2_HUMAN	olfactory receptor, family 5, subfamily AP, member 2	144					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(5)|liver(1)|lung(11)|ovary(1)|skin(2)|upper_aerodigestive_tract(2)	29						AGCAAATTCTCCCAGACACGA	0.488000													15	58					2.32078e-09	2.99515e-09	1	1	0
CLUL1	27098	broad.mit.edu	37	18	644961	644961	+	Missense_Mutation	SNP	A	A	C			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr18:644961A>C	ENST00000581619.1	+	8	2183	c.1336A>C	c.(1336-1338)Atg>Ctg	p.M446L	CLUL1_ENST00000338387.7_Missense_Mutation_p.M421L|CLUL1_ENST00000579494.1_Missense_Mutation_p.M421L|CLUL1_ENST00000540035.1_Missense_Mutation_p.M473L|CLUL1_ENST00000400606.2_Missense_Mutation_p.M421L|C18orf56_ENST00000585033.1_Intron			Q15846	CLUL1_HUMAN	clusterin-like 1 (retinal)	421					cell death	extracellular region				NS(1)|breast(1)|endometrium(5)|large_intestine(5)|liver(2)|lung(7)|ovary(2)|skin(1)	24						TGAAACAATGATGACAGACTT	0.373000													5	59					0	0	1	0	0
DCDC1	341019	broad.mit.edu	37	11	31327898	31327898	+	Silent	SNP	G	G	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr11:31327898G>T	ENST00000597505.1	-	3	471	c.472C>A	c.(472-474)Cgg>Agg	p.R158R	DCDC1_ENST00000452803.1_Silent_p.R158R|RP1-296L11.1_ENST00000528872.1_RNA			P59894	DCDC1_HUMAN	doublecortin domain containing 1	158					intracellular signal transduction					central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(17)|pancreas(2)|prostate(1)|skin(1)|stomach(1)	31	Lung SC(675;0.225)					TGCCAATTCCGGGCTGACTGA	0.338000													4	31					1	1	1	1	0
BRWD3	254065	broad.mit.edu	37	X	79932441	79932441	+	Missense_Mutation	SNP	C	C	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chrX:79932441C>A	ENST00000373275.4	-	41	5292	c.5076G>T	c.(5074-5076)agG>agT	p.R1692S		NM_153252.4	NP_694984.4	Q6RI45	BRWD3_HUMAN	bromodomain and WD repeat domain containing 3	1692	Gly-rich.									breast(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|lung(39)|ovary(4)|prostate(2)|skin(3)	87						tccctcgtcccctgcctcctc	0.572000													55	56					3.76997e-23	5.64922e-23	1	1	0
SOX13	9580	broad.mit.edu	37	1	204085650	204085650	+	Missense_Mutation	SNP	T	T	G			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr1:204085650T>G	ENST00000367204.1	+	5	543	c.434T>G	c.(433-435)cTa>cGa	p.L145R	SOX13_ENST00000367203.4_3'UTR	NM_005686.2	NP_005677.2	Q9UN79	SOX13_HUMAN	SRY (sex determining region Y)-box 13	145					anatomical structure morphogenesis	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(3)|lung(2)|ovary(2)|prostate(2)	13	all_cancers(21;0.0754)|Breast(84;0.116)|all_epithelial(62;0.189)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.109)			CAAGAGAGCCTAGCAGAGAAG	0.527000													9	73					0	0	1	0	0
GRM8	2918	broad.mit.edu	37	7	126544083	126544083	+	Missense_Mutation	SNP	G	G	C			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr7:126544083G>C	ENST00000339582.2	-	5	1769	c.961C>G	c.(961-963)Caa>Gaa	p.Q321E	GRM8_ENST00000444921.2_Missense_Mutation_p.Q321E|GRM8_ENST00000405249.1_Missense_Mutation_p.Q321E|GRM8_ENST00000358373.3_Missense_Mutation_p.Q321E|GRM8_ENST00000480995.1_5'UTR			O00222	GRM8_HUMAN	glutamate receptor, metabotropic 8	321					negative regulation of cAMP biosynthetic process|sensory perception of smell|visual perception	integral to plasma membrane				breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|large_intestine(16)|lung(62)|ovary(5)|pancreas(1)|prostate(1)|skin(14)|stomach(1)|upper_aerodigestive_tract(6)|urinary_tract(4)	125		Prostate(267;0.186)			L-Glutamic Acid(DB00142)	ATCTCCTCTTGCTGATAGACA	0.418000										HNSCC(24;0.065)			85	64					0	0	1	0	0
OR4K5	79317	broad.mit.edu	37	14	20389633	20389633	+	Silent	SNP	A	A	C			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr14:20389633A>C	ENST00000315915.4	+	1	893	c.868A>C	c.(868-870)Agg>Cgg	p.R290R		NM_001005483.1	NP_001005483.1	Q8NGD3	OR4K5_HUMAN	olfactory receptor, family 4, subfamily K, member 5	290					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(6)|liver(1)|lung(27)|ovary(1)|skin(3)|stomach(1)|urinary_tract(1)	47	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		TTATACACTAAGGAATAGGGA	0.403000													29	216					0	0	1	0	0
FREM2	341640	broad.mit.edu	37	13	39262919	39262919	+	Missense_Mutation	SNP	C	C	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr13:39262919C>T	ENST00000280481.7	+	1	1654	c.1438C>T	c.(1438-1440)Cgg>Tgg	p.R480W		NM_207361.4	NP_997244.3	Q5SZK8	FREM2_HUMAN	FRAS1 related extracellular matrix protein 2	480					cell communication|homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(35)|lung(39)|ovary(9)|pancreas(2)|prostate(12)|skin(11)|upper_aerodigestive_tract(7)|urinary_tract(2)	148		Lung NSC(96;1.04e-07)|Prostate(109;0.00384)|Breast(139;0.00396)|Lung SC(185;0.0565)|Hepatocellular(188;0.114)		all cancers(112;3.32e-07)|Epithelial(112;1.66e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00154)|BRCA - Breast invasive adenocarcinoma(63;0.00631)|GBM - Glioblastoma multiforme(144;0.0312)		AGAAGCAGTGCGGCTAGAGGT	0.582000													12	46					0	0	1	0	0
SCAF1	58506	broad.mit.edu	37	19	50148391	50148391	+	Splice_Site	SNP	G	G	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr19:50148391G>A	ENST00000360565.3	+	2	232	c.108_splice	c.e2+1	p.L36_splice		NM_021228.2	NP_067051.2	Q9H7N4	SFR19_HUMAN	SR-related CTD-associated factor 1	36					mRNA processing|RNA splicing	nucleus	RNA binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(2)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	20		all_lung(116;1.05e-05)|Lung NSC(112;3.77e-05)|all_neural(266;0.196)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.00113)|GBM - Glioblastoma multiforme(134;0.0204)		CCTTTATCCTGGTGAGGCTGC	0.632000													14	27					0	0	1	0	0
ADAMTS4	9507	broad.mit.edu	37	1	161167827	161167827	+	Missense_Mutation	SNP	C	C	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr1:161167827C>A	ENST00000367996.4	-	1	1019	c.591G>T	c.(589-591)aaG>aaT	p.K197N	ADAMTS4_ENST00000367995.3_Missense_Mutation_p.K197N	NM_005099.4	NP_005090.3	O75173	ATS4_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 4	197					proteolysis|skeletal system development	extracellular space|proteinaceous extracellular matrix	metalloendopeptidase activity|protease binding|zinc ion binding			central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(20)|ovary(4)|prostate(3)|skin(1)|urinary_tract(1)	43	all_cancers(52;3.73e-19)|Breast(13;0.000577)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00275)			CAAGAGGAGCCTTGACGTTGC	0.632000													12	87					0.0135373	0.0140355	1	1	0
FGD6	55785	broad.mit.edu	37	12	95602758	95602758	+	Missense_Mutation	SNP	C	C	G			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr12:95602758C>G	ENST00000343958.4	-	2	2525	c.2302G>C	c.(2302-2304)Gct>Cct	p.A768P	FGD6_ENST00000546711.1_Missense_Mutation_p.A768P|FGD6_ENST00000549499.1_Missense_Mutation_p.A768P	NM_018351.3	NP_060821.3	Q6ZV73	FGD6_HUMAN	FYVE, RhoGEF and PH domain containing 6	768					actin cytoskeleton organization|filopodium assembly|regulation of Cdc42 GTPase activity|regulation of cell shape	cytoskeleton|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			breast(3)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(14)|liver(1)|lung(12)|ovary(3)|prostate(3)|skin(6)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	56						TTCCGTATAGCCATAATAAAT	0.448000													15	79					0	0	1	0	0
RNGTT	8732	broad.mit.edu	37	6	89600224	89600224	+	Missense_Mutation	SNP	C	C	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr6:89600224C>A	ENST00000369485.4	-	8	1072	c.886G>T	c.(886-888)Gat>Tat	p.D296Y	RNGTT_ENST00000369475.3_Missense_Mutation_p.D296Y|RNGTT_ENST00000265607.6_Missense_Mutation_p.D296Y|RNGTT_ENST00000538899.1_Missense_Mutation_p.D236Y	NM_003800.3	NP_003791.3	O60942	MCE1_HUMAN	RNA guanylyltransferase and 5'-phosphatase	296	GTase.				interspecies interaction between organisms|mRNA capping|transcription from RNA polymerase II promoter|viral reproduction	nucleoplasm	GTP binding|mRNA guanylyltransferase activity|polynucleotide 5'-phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			endometrium(1)|large_intestine(7)|lung(6)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)	21		all_cancers(76;4.07e-09)|Prostate(29;1.16e-10)|Acute lymphoblastic leukemia(125;1.49e-10)|all_hematologic(105;7.79e-07)|all_epithelial(107;6.86e-05)		BRCA - Breast invasive adenocarcinoma(108;0.151)		CGAGTACCATCTGCTTTCCAG	0.353000													10	31					0.000442599	0.00048115	1	1	0
RABEP2	79874	broad.mit.edu	37	16	28922245	28922245	+	Silent	SNP	G	G	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr16:28922245G>A	ENST00000358201.4	-	7	1641	c.1053C>T	c.(1051-1053)acC>acT	p.T351T	RABEP2_ENST00000357573.6_Silent_p.T319T|RABEP2_ENST00000544477.1_Silent_p.T280T	NM_024816.2	NP_079092.2	Q9H5N1	RABE2_HUMAN	rabaptin, RAB GTPase binding effector protein 2	351					endocytosis|protein transport	early endosome	growth factor activity|GTPase activator activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(3)|lung(6)|ovary(1)|skin(1)	16						CCTGGCTCACGGTCCCTTGCA	0.652000													11	69					0	0	1	0	0
CAPRIN2	65981	broad.mit.edu	37	12	30862919	30862919	+	Missense_Mutation	SNP	A	A	G			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr12:30862919A>G	ENST00000251071.5	-	18	4051	c.3301T>C	c.(3301-3303)Tgg>Cgg	p.W1101R	CAPRIN2_ENST00000298892.5_Missense_Mutation_p.W1051R|CAPRIN2_ENST00000395805.2_3'UTR|CAPRIN2_ENST00000308433.5_Missense_Mutation_p.W767R	NM_001002259.1|NM_032156.3	NP_001002259.1|NP_115532.3	Q6IMN6	CAPR2_HUMAN	caprin family member 2	1101	C1q.				negative regulation of cell growth|negative regulation of translation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of dendrite morphogenesis|positive regulation of dendritic spine morphogenesis|positive regulation of peptidyl-serine phosphorylation|positive regulation of protein binding|positive regulation of transcription from RNA polymerase II promoter	mitochondrion|receptor complex	receptor binding|RNA binding			breast(1)|central_nervous_system(1)|endometrium(8)|kidney(4)|large_intestine(13)|lung(16)|ovary(1)|prostate(2)|skin(1)|urinary_tract(1)	48	all_lung(12;1.13e-09)|Lung NSC(12;7.98e-08)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0355)|Lung SC(12;0.0905)|Esophageal squamous(101;0.233)					AGACGTAACCATATCTGGTCT	0.428000													28	97					0	0	1	0	0
SLC46A2	57864	broad.mit.edu	37	9	115652031	115652031	+	Missense_Mutation	SNP	C	C	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr9:115652031C>T	ENST00000374228.4	-	1	1162	c.931G>A	c.(931-933)Gag>Aag	p.E311K		NM_033051.3	NP_149040.3	Q9BY10	TSCOT_HUMAN	solute carrier family 46, member 2	311						integral to membrane|plasma membrane	symporter activity			central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(11)|pancreas(1)|skin(1)	18						CCGAGAGGCTCCCTCAGCACA	0.552000													17	30					0	0	1	0	0
LPA	4018	broad.mit.edu	37	6	161027691	161027691	+	Splice_Site	SNP	C	C	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr6:161027691C>A	ENST00000447678.1	-	18	2724		c.e18-1		LPA_ENST00000316300.5_Splice_Site	NM_005577.2	NP_005568.2	P08519	APOA_HUMAN	lipoprotein, Lp(a)						blood circulation|lipid metabolic process|lipid transport|lipoprotein metabolic process|proteolysis|receptor-mediated endocytosis	plasma lipoprotein particle	apolipoprotein binding|endopeptidase inhibitor activity|fibronectin binding|heparin binding|serine-type endopeptidase activity			NS(1)|breast(3)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(16)|lung(54)|ovary(4)|pancreas(1)|prostate(2)|skin(10)|stomach(1)|urinary_tract(1)	107		Breast(66;0.000496)|Ovarian(120;0.0303)|Prostate(117;0.0965)		OV - Ovarian serous cystadenocarcinoma(65;2.5e-17)|BRCA - Breast invasive adenocarcinoma(81;6.48e-06)	Aminocaproic Acid(DB00513)	GATCAAGCCACTGGAAATTCC	0.512000													19	160					4.96729e-08	6.19184e-08	1	1	0
OR8K1	390157	broad.mit.edu	37	11	56113853	56113853	+	Missense_Mutation	SNP	C	C	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr11:56113853C>A	ENST00000279783.2	+	1	433	c.339C>A	c.(337-339)ttC>ttA	p.F113L		NM_001002907.1	NP_001002907.1	Q8NGG5	OR8K1_HUMAN	olfactory receptor, family 8, subfamily K, member 1	113					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(8)|liver(2)|lung(13)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	33	Esophageal squamous(21;0.00448)					TTGAGATTTTCATCATCTCTG	0.408000										HNSCC(65;0.19)			27	160					7.92952e-12	1.07545e-11	1	1	0
INPP5B	3633	broad.mit.edu	37	1	38397646	38397646	+	Silent	SNP	T	T	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr1:38397646T>A	ENST00000373023.2	-	7	564	c.471A>T	c.(469-471)ccA>ccT	p.P157P	INPP5B_ENST00000373021.1_Silent_p.P157P|INPP5B_ENST00000373024.3_Silent_p.P157P|INPP5B_ENST00000373026.1_Silent_p.P157P	NM_005540.2	NP_005531.2	P32019	I5P2_HUMAN	inositol polyphosphate-5-phosphatase, 75kDa	157					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|integral to membrane|microtubule cytoskeleton	GTPase activator activity|inositol-polyphosphate 5-phosphatase activity|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|protein binding			breast(1)|endometrium(2)|large_intestine(1)|liver(1)|lung(9)|urinary_tract(1)	15	Acute lymphoblastic leukemia(166;0.074)|all_hematologic(146;0.197)	Myeloproliferative disorder(586;0.0255)				CGCGCGGCGTTGGCATCTCCA	0.607000													9	81					0	0	1	0	0
PROM1	8842	broad.mit.edu	37	4	15995667	15995667	+	Nonsense_Mutation	SNP	G	G	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr4:15995667G>T	ENST00000505450.1	-	15	2295	c.1683C>A	c.(1681-1683)taC>taA	p.Y561*	PROM1_ENST00000540805.1_Nonsense_Mutation_p.Y570*|PROM1_ENST00000447510.2_Nonsense_Mutation_p.Y570*|PROM1_ENST00000508167.1_Nonsense_Mutation_p.Y561*|PROM1_ENST00000510224.1_Nonsense_Mutation_p.Y570*|PROM1_ENST00000543373.1_Nonsense_Mutation_p.Y561*|PROM1_ENST00000539194.1_Nonsense_Mutation_p.Y570*	NM_001145848.1	NP_001139320.1	O43490	PROM1_HUMAN	prominin 1	570					camera-type eye photoreceptor cell differentiation|photoreceptor cell maintenance|retina layer formation	apical plasma membrane|cell surface|integral to plasma membrane|microvillus membrane|photoreceptor outer segment membrane|plasma membrane	beta-actinin binding|cadherin binding			breast(2)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(4)|liver(1)|lung(11)|ovary(3)|pancreas(1)|upper_aerodigestive_tract(2)	35						GAAGAGTGCCGTAAGTGCCTC	0.418000													9	55					0.000274275	0.000299485	1	1	0
GRM3	2913	broad.mit.edu	37	7	86415744	86415744	+	Nonsense_Mutation	SNP	C	C	G			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr7:86415744C>G	ENST00000361669.2	+	3	1735	c.636C>G	c.(634-636)taC>taG	p.Y212*	GRM3_ENST00000546348.1_Intron|GRM3_ENST00000394720.2_Nonsense_Mutation_p.Y210*|GRM3_ENST00000439827.1_Nonsense_Mutation_p.Y212*|AC005009.2_ENST00000418031.1_RNA|GRM3_ENST00000536043.1_Nonsense_Mutation_p.Y84*|AC005009.2_ENST00000452471.1_RNA	NM_000840.2	NP_000831.2	Q14832	GRM3_HUMAN	glutamate receptor, metabotropic 3	212					synaptic transmission	integral to plasma membrane				NS(2)|breast(6)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(43)|ovary(3)|pancreas(2)|prostate(4)|skin(25)|upper_aerodigestive_tract(5)	109	Esophageal squamous(14;0.0058)|all_lung(186;0.132)|Lung NSC(181;0.142)				Acamprosate(DB00659)|Nicotine(DB00184)	ACTGGACCTACGTGTCCACAG	0.587000													19	121					0	0	1	0	0
FAT2	2196	broad.mit.edu	37	5	150948476	150948476	+	Missense_Mutation	SNP	A	A	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr5:150948476A>T	ENST00000261800.5	-	1	29	c.17T>A	c.(16-18)cTg>cAg	p.L6Q		NM_001447.2	NP_001438.1	Q9NYQ8	FAT2_HUMAN	FAT atypical cadherin 2	6					epithelial cell migration|homophilic cell adhesion	cell-cell adherens junction|integral to membrane|nucleus	calcium ion binding			NS(6)|breast(3)|central_nervous_system(3)|cervix(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(61)|liver(1)|lung(60)|ovary(6)|prostate(5)|skin(5)|stomach(2)|upper_aerodigestive_tract(11)|urinary_tract(1)	196		Medulloblastoma(196;0.0912)|all_hematologic(541;0.104)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			GGCAAAACCCAGCAGGGCAAT	0.473000													14	47					0	0	1	0	0
NLGN4X	57502	broad.mit.edu	37	X	5811206	5811206	+	Missense_Mutation	SNP	G	G	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chrX:5811206G>T	ENST00000381095.3	-	6	2730	c.2103C>A	c.(2101-2103)gaC>gaA	p.D701E	NLGN4X_ENST00000381092.1_Missense_Mutation_p.D701E|NLGN4X_ENST00000275857.6_Missense_Mutation_p.D701E|NLGN4X_ENST00000381093.2_Missense_Mutation_p.D721E|NLGN4X_ENST00000538097.1_Missense_Mutation_p.D701E	NM_181332.1	NP_851849.1	Q8N0W4	NLGNX_HUMAN	neuroligin 4, X-linked	701					brainstem development|cell adhesion|cell-cell junction organization|cerebellum development|male courtship behavior|positive regulation of organ growth|regulation of excitatory postsynaptic membrane potential|social behavior|synapse assembly|territorial aggressive behavior|vocalization behavior	cell surface|dendrite|integral to plasma membrane|synapse	chloride ion binding|neurexin binding|protein homodimerization activity|receptor activity			breast(1)|cervix(2)|endometrium(4)|large_intestine(21)|lung(39)|ovary(4)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)	81						GGCGCCTCTTGTCCTTTTTGT	0.507000													22	36					1.10513e-12	1.51975e-12	1	1	0
KIF5A	3798	broad.mit.edu	37	12	57975352	57975352	+	Splice_Site	SNP	G	G	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr12:57975352G>T	ENST00000455537.2	+	25	3183		c.e25+1		KIF5A_ENST00000286452.5_Splice_Site	NM_004984.2	NP_004975.2	Q12840	KIF5A_HUMAN	kinesin family member 5A						blood coagulation|cell death|microtubule-based movement|synaptic transmission	cytosol|kinesin complex|membrane fraction|microtubule|perinuclear region of cytoplasm	ATP binding|microtubule motor activity			breast(2)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(11)|liver(1)|lung(32)|ovary(2)|prostate(2)|skin(2)	62						CAGATATGTAGTGAGTGACCA	0.542000													10	78					3.07112e-06	3.59634e-06	1	1	0
ABCA2	20	broad.mit.edu	37	9	139907980	139907980	+	Missense_Mutation	SNP	A	A	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr9:139907980A>T	ENST00000265662.5	-	29	4630	c.4483T>A	c.(4483-4485)Tac>Aac	p.Y1495N	ABCA2_ENST00000341511.6_Missense_Mutation_p.Y1495N|ABCA2_ENST00000371605.3_Missense_Mutation_p.Y1494N			Q9BZC7	ABCA2_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 2	1494					cholesterol homeostasis|lipid metabolic process|regulation of intracellular cholesterol transport|regulation of transcription from RNA polymerase II promoter|response to drug|response to steroid hormone stimulus	ATP-binding cassette (ABC) transporter complex|cytoplasmic membrane-bounded vesicle|endosome|integral to membrane|microtubule organizing center	ATP binding|ATPase activity, coupled to transmembrane movement of substances			central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|liver(1)|lung(25)|prostate(2)|skin(1)|stomach(1)|urinary_tract(1)	41	all_cancers(76;0.16)	Myeloproliferative disorder(178;0.0511)	STAD - Stomach adenocarcinoma(284;0.123)	OV - Ovarian serous cystadenocarcinoma(145;2.94e-05)|Epithelial(140;0.00048)		TAGTTGTGGTACTGGGAAGGT	0.682000													3	7					0	0	1	0	0
ABCB1	5243	broad.mit.edu	37	7	87214952	87214952	+	Silent	SNP	T	T	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr7:87214952T>A	ENST00000265724.3	-	5	579	c.162A>T	c.(160-162)ggA>ggT	p.G54G	ABCB1_ENST00000543898.1_Silent_p.G54G	NM_000927.4	NP_000918.2	P08183	MDR1_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 1	54	ABC transmembrane type-1 1.				G2/M transition of mitotic cell cycle|stem cell proliferation	apical plasma membrane|cell surface|Golgi membrane|integral to membrane|intercellular canaliculus|membrane fraction	ATP binding|protein binding|xenobiotic-transporting ATPase activity			NS(1)|breast(6)|central_nervous_system(2)|endometrium(14)|kidney(9)|large_intestine(14)|lung(48)|ovary(4)|prostate(6)|skin(6)|upper_aerodigestive_tract(1)	111	Esophageal squamous(14;0.00164)				Adenosine triphosphate(DB00171)|Alfentanil(DB00802)|Arsenic trioxide(DB01169)|Atazanavir(DB01072)|Carvedilol(DB01136)|Colchicine(DB01394)|Cyclosporine(DB00091)|Daunorubicin(DB00694)|Dipyridamole(DB00975)|Estramustine(DB01196)|Flupenthixol(DB00875)|Imatinib(DB00619)|Itraconazole(DB01167)|Nicardipine(DB00622)|Propafenone(DB01182)|Quinacrine(DB01103)|Quinidine(DB00908)|Ranolazine(DB00243)|Rifampin(DB01045)|Roxithromycin(DB00778)|Saquinavir(DB01232)|Tamoxifen(DB00675)|Vinblastine(DB00570)	CAGCCAAAGTTCCCACCACCA	0.393000													5	39					0	0	1	0	0
KIAA0020	9933	broad.mit.edu	37	9	2810388	2810388	+	Missense_Mutation	SNP	C	C	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr9:2810388C>A	ENST00000397885.2	-	16	1885	c.1679G>T	c.(1678-1680)tGg>tTg	p.W560L		NM_014878.4	NP_055693.4	Q15397	K0020_HUMAN	KIAA0020	560						endoplasmic reticulum|nucleolus	RNA binding			NS(1)|breast(2)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(7)|lung(4)|ovary(1)	21				GBM - Glioblastoma multiforme(50;0.0319)		CTCTATTAACCACTTCAGAAC	0.343000													9	30					0.000673444	0.0007257	1	1	0
COL27A1	85301	broad.mit.edu	37	9	117002713	117002713	+	Splice_Site	SNP	G	G	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr9:117002713G>T	ENST00000356083.3	+	21	3172		c.e21-1			NM_032888.2	NP_116277.2	Q8IZC6	CORA1_HUMAN	collagen, type XXVII, alpha 1						cell adhesion		extracellular matrix structural constituent			central_nervous_system(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(17)|lung(30)|ovary(4)|prostate(6)|skin(3)|soft_tissue(1)|stomach(1)|urinary_tract(3)	80						CTTCTCCCCAGGGTAAGCCTG	0.667000													63	94					8.70598e-44	1.34547e-43	1	1	0
POU6F2	11281	broad.mit.edu	37	7	39243895	39243895	+	Missense_Mutation	SNP	G	G	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr7:39243895G>T	ENST00000518318.2	+	3	294	c.252G>T	c.(250-252)caG>caT	p.Q84H	POU6F2_ENST00000517348.1_3'UTR|POU6F2_ENST00000403058.1_Missense_Mutation_p.Q84H|POU6F2_ENST00000559001.1_Missense_Mutation_p.Q76H			P78424	PO6F2_HUMAN	POU class 6 homeobox 2	84					central nervous system development|ganglion mother cell fate determination|transcription from RNA polymerase II promoter|visual perception		sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			NS(3)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(16)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	42						AGGCCAGTCAGACCCACCCCC	0.468000													5	38					0.014758	0.0152052	1	1	0
ITPR1	3708	broad.mit.edu	37	3	4715045	4715045	+	Missense_Mutation	SNP	G	G	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr3:4715045G>T	ENST00000302640.8	+	20	2735	c.2385G>T	c.(2383-2385)gaG>gaT	p.E795D	ITPR1_ENST00000443694.2_Missense_Mutation_p.E795D|ITPR1_ENST00000423119.2_Missense_Mutation_p.E810D|ITPR1_ENST00000354582.6_Missense_Mutation_p.E810D|ITPR1_ENST00000456211.2_Missense_Mutation_p.E795D|ITPR1_ENST00000357086.4_Missense_Mutation_p.E810D|ITPR1_ENST00000544951.1_Intron	NM_001168272.1	NP_001161744.1	Q14643	ITPR1_HUMAN	inositol 1,4,5-trisphosphate receptor, type 1	810					activation of phospholipase C activity|cell death|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	endoplasmic reticulum membrane|integral to membrane|platelet dense granule membrane|platelet dense tubular network membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|intracellular ligand-gated calcium channel activity|phosphatidylinositol binding|protein binding			NS(1)|autonomic_ganglia(1)|breast(10)|endometrium(15)|kidney(6)|large_intestine(27)|liver(1)|lung(27)|ovary(6)|pancreas(1)|prostate(4)|skin(5)|urinary_tract(2)	106				Epithelial(13;0.0199)|OV - Ovarian serous cystadenocarcinoma(96;0.0361)|all cancers(10;0.0982)		TCTGGTCGGAGATTCCCTCGG	0.542000													16	114					6.49762e-13	8.94784e-13	1	1	0
BSX	390259	broad.mit.edu	37	11	122850143	122850143	+	Missense_Mutation	SNP	G	G	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr11:122850143G>T	ENST00000343035.2	-	2	333	c.285C>A	c.(283-285)ttC>ttA	p.F95L		NM_001098169.1	NP_001091639.1	Q3C1V8	BSH_HUMAN	brain-specific homeobox	95										endometrium(1)|kidney(1)|large_intestine(3)|lung(3)|prostate(2)	10		Breast(109;0.00249)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0361)		GCGGGTGCGGGAACAGCGCTG	0.677000													6	69					3.59834e-05	4.04556e-05	1	1	0
SMAGP	57228	broad.mit.edu	37	12	51639796	51639796	+	Missense_Mutation	SNP	C	C	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr12:51639796C>T	ENST00000603798.1	-	4	895	c.223G>A	c.(223-225)Gag>Aag	p.E75K	DAZAP2_ENST00000604900.1_Intron|DAZAP2_ENST00000425012.2_Intron|SMAGP_ENST00000398453.3_Missense_Mutation_p.E75K|SMAGP_ENST00000605627.1_Missense_Mutation_p.E61K|SMAGP_ENST00000603864.1_Missense_Mutation_p.E75K	NM_001031628.1	NP_001026798.1	Q0VAQ4	SMAGP_HUMAN	small cell adhesion glycoprotein	75						cytoplasmic vesicle membrane|integral to membrane|plasma membrane											GCACTGGGCTCACCTTCTGTA	0.507000													13	86					0	0	1	0	0
TRHDE	29953	broad.mit.edu	37	12	72667125	72667125	+	Silent	SNP	G	G	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr12:72667125G>A	ENST00000261180.4	+	1	663	c.567G>A	c.(565-567)gtG>gtA	p.V189V	TRHDE-AS1_ENST00000426250.3_RNA	NM_013381.2	NP_037513.1	Q9UKU6	TRHDE_HUMAN	thyrotropin-releasing hormone degrading enzyme	189					cell-cell signaling|proteolysis|signal transduction	integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(8)|kidney(3)|large_intestine(13)|lung(38)|ovary(2)|skin(4)|soft_tissue(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	79						GAGTGGCGGTGGAGAAAGTGC	0.612000													19	110					0	0	1	0	0
HP1BP3	50809	broad.mit.edu	37	1	21099998	21099998	+	Silent	SNP	C	C	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr1:21099998C>A	ENST00000312239.5	-	5	595	c.456G>T	c.(454-456)ccG>ccT	p.P152P	HP1BP3_ENST00000375003.2_5'UTR	NM_016287.3	NP_057371.2	Q5SSJ5	HP1B3_HUMAN	heterochromatin protein 1, binding protein 3	152					nucleosome assembly	nucleosome|nucleus	DNA binding			central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(5)|prostate(2)|skin(2)|urinary_tract(1)	16		all_lung(284;6.55e-06)|Lung NSC(340;6.59e-06)|Colorectal(325;3.46e-05)|Renal(390;9.67e-05)|Breast(348;0.00179)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0182)|COAD - Colon adenocarcinoma(152;1.26e-05)|BRCA - Breast invasive adenocarcinoma(304;0.00015)|GBM - Glioblastoma multiforme(114;0.000521)|Kidney(64;0.000529)|STAD - Stomach adenocarcinoma(196;0.00311)|KIRC - Kidney renal clear cell carcinoma(64;0.00687)|READ - Rectum adenocarcinoma(331;0.0655)|Lung(427;0.201)		AAGAAGCCATCGGTGTTTGTT	0.418000													10	58					9.70103e-10	1.25858e-09	1	1	0
PDLIM3	27295	broad.mit.edu	37	4	186425735	186425735	+	Missense_Mutation	SNP	G	G	C			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr4:186425735G>C	ENST00000284770.5	-	7	872	c.799C>G	c.(799-801)Cgt>Ggt	p.R267G	PDLIM3_ENST00000284771.6_Missense_Mutation_p.R219G|PDLIM3_ENST00000284767.5_3'UTR	NM_014476.5	NP_055291.2	Q53GG5	PDLI3_HUMAN	PDZ and LIM domain 3	267						sarcomere	zinc ion binding			breast(2)|endometrium(1)|large_intestine(1)|lung(5)|ovary(2)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	17		all_lung(41;1.03e-13)|Lung NSC(41;2.49e-13)|Melanoma(20;1.91e-06)|Hepatocellular(41;0.00826)|Renal(120;0.00988)|Prostate(90;0.00996)|Colorectal(36;0.0161)|all_hematologic(60;0.0592)|all_neural(102;0.243)		OV - Ovarian serous cystadenocarcinoma(60;1.4e-10)|BRCA - Breast invasive adenocarcinoma(30;8.64e-05)|GBM - Glioblastoma multiforme(59;0.000167)|STAD - Stomach adenocarcinoma(60;0.000828)|LUSC - Lung squamous cell carcinoma(40;0.00984)|COAD - Colon adenocarcinoma(29;0.0115)|READ - Rectum adenocarcinoma(43;0.171)		CCAGCCGGACGGTCATCTGAA	0.537000													17	30					0	0	1	0	0
PAK1	5058	broad.mit.edu	37	11	77090368	77090368	+	Silent	SNP	T	T	C	rs115947709	byFrequency	TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr11:77090368T>C	ENST00000356341.3	-	4	888	c.357A>G	c.(355-357)aaA>aaG	p.K119K	PAK1_ENST00000530617.1_Silent_p.K119K|PAK1_ENST00000528203.1_Silent_p.K21K|PAK1_ENST00000278568.4_Silent_p.K119K	NM_002576.4	NP_002567.3	Q13153	PAK1_HUMAN	p21 protein (Cdc42/Rac)-activated kinase 1	119	Autoregulatory region.				apoptosis|axon guidance|cytoskeleton organization|ER-nucleus signaling pathway|positive regulation of JUN kinase activity|positive regulation of peptidyl-serine phosphorylation|protein autophosphorylation|T cell costimulation|T cell receptor signaling pathway	cytosol|focal adhesion|Golgi apparatus	ATP binding|collagen binding|protein binding|protein serine/threonine kinase activity			NS(1)|breast(1)|endometrium(2)|kidney(3)|large_intestine(6)|lung(13)|skin(2)|stomach(1)	29	all_cancers(14;1.75e-18)					CCTGCGGGTTTTTCTTCTGCT	0.473000													9	96					0	0	1	0	0
GSE1	23199	broad.mit.edu	37	16	85694872	85694872	+	Silent	SNP	C	C	G			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr16:85694872C>G	ENST00000253458.7	+	9	1937	c.1761C>G	c.(1759-1761)ccC>ccG	p.P587P	GSE1_ENST00000405402.2_Silent_p.P483P|GSE1_ENST00000393243.1_Silent_p.P514P	NM_014615.2	NP_055430.1			Gse1 coiled-coil protein																		TCTGGAACCCCGTGTCCCTGA	0.677000													20	84					0	0	1	0	0
GLYAT	10249	broad.mit.edu	37	11	58480264	58480264	+	Silent	SNP	G	G	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr11:58480264G>T	ENST00000344743.3	-	4	426	c.285C>A	c.(283-285)ctC>ctA	p.L95L	GLYAT_ENST00000529732.1_Silent_p.L95L|GLYAT_ENST00000278400.3_Silent_p.L95L	NM_201648.2	NP_964011.2	Q6IB77	GLYAT_HUMAN	glycine-N-acyltransferase	95					acyl-CoA metabolic process|response to toxin|xenobiotic metabolic process	mitochondrial matrix	glycine N-acyltransferase activity|glycine N-benzoyltransferase activity			NS(1)|autonomic_ganglia(1)|kidney(1)|large_intestine(3)|lung(8)|skin(1)|urinary_tract(1)	16		Breast(21;0.0044)|all_epithelial(135;0.0157)			Glycine(DB00145)	TCCAGTTGATGAGTTCTGGTG	0.388000													11	58					5.50884e-06	6.36778e-06	1	1	0
KLHL2	11275	broad.mit.edu	37	4	166235212	166235212	+	Silent	SNP	A	A	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr4:166235212A>T	ENST00000226725.6	+	13	1762	c.1503A>T	c.(1501-1503)gtA>gtT	p.V501V	KLHL2_ENST00000506761.1_Silent_p.V335V|KLHL2_ENST00000421009.2_Silent_p.V404V|KLHL2_ENST00000538127.1_Silent_p.V413V|KLHL2_ENST00000509028.1_3'UTR|KLHL2_ENST00000514860.1_Silent_p.V505V	NM_007246.3	NP_009177.3	O95198	KLHL2_HUMAN	kelch-like family member 2	501					intracellular protein transport	actin cytoskeleton|cytoplasm	actin binding|transporter activity			endometrium(3)|large_intestine(5)|lung(4)|prostate(1)|urinary_tract(1)	14	all_hematologic(180;0.221)			GBM - Glioblastoma multiforme(119;2.94e-27)|COAD - Colon adenocarcinoma(41;1.4e-05)|Kidney(143;4.95e-05)|KIRC - Kidney renal clear cell carcinoma(143;0.000927)		TGTATGCTGTAGGAGGTCATG	0.378000													26	123					0	0	1	0	0
SIGLEC5	8778	broad.mit.edu	37	19	52130739	52130739	+	Missense_Mutation	SNP	T	T	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr19:52130739T>A	ENST00000222107.4	-	6	1396	c.1258A>T	c.(1258-1260)Agc>Tgc	p.S420C	SIGLEC5_ENST00000570106.2_Missense_Mutation_p.S420C|SIGLEC5_ENST00000534261.2_Missense_Mutation_p.S420C|SIGLEC5_ENST00000429354.3_Missense_Mutation_p.S420C|SIGLEC5_ENST00000599649.1_Missense_Mutation_p.S420C			O15389	SIGL5_HUMAN	sialic acid binding Ig-like lectin 5	420					cell adhesion	integral to membrane	sugar binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(3)|large_intestine(4)|lung(9)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)	27		all_neural(266;0.0726)		GBM - Glioblastoma multiforme(134;0.00124)|OV - Ovarian serous cystadenocarcinoma(262;0.0218)		ACAGAGCCGCTCTGGGACCCA	0.642000													49	96					0	0	1	0	0
LIN54	132660	broad.mit.edu	37	4	83867567	83867567	+	Missense_Mutation	SNP	T	T	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr4:83867567T>A	ENST00000340417.3	-	5	1389	c.1012A>T	c.(1012-1014)Aca>Tca	p.T338S	LIN54_ENST00000505397.1_Missense_Mutation_p.T338S|LIN54_ENST00000510557.1_Missense_Mutation_p.T117S|LIN54_ENST00000442461.2_Missense_Mutation_p.T117S|LIN54_ENST00000395282.2_3'UTR|LIN54_ENST00000446851.2_Missense_Mutation_p.T117S|LIN54_ENST00000395283.2_Missense_Mutation_p.T249S|LIN54_ENST00000506560.1_Missense_Mutation_p.T249S	NM_194282.2	NP_919258.2	Q6MZP7	LIN54_HUMAN	lin-54 homolog (C. elegans)	338					cell cycle|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			breast(2)|endometrium(2)|kidney(3)|large_intestine(2)|lung(5)	14		Hepatocellular(203;0.114)				GGAATAATTGTCTTAAACTGT	0.443000													12	99					0	0	1	0	0
KRTAP10-7	386675	broad.mit.edu	37	21	46021089	46021089	+	Missense_Mutation	SNP	C	C	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr21:46021089C>A	ENST00000380102.2	+	1	593	c.568C>A	c.(568-570)Ccc>Acc	p.P190T	TSPEAR_ENST00000323084.4_Intron	NM_198689.2	NP_941962.1	P60409	KR107_HUMAN	keratin associated protein 10-7	190	30 X 5 AA repeats of C-C-X(3).					keratin filament				breast(1)|large_intestine(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	8						TGTGTCCAGCCCCTGCTGCCA	0.642000													13	132					6.49762e-13	8.94784e-13	1	1	0
BMP15	9210	broad.mit.edu	37	X	50654045	50654045	+	Missense_Mutation	SNP	C	C	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chrX:50654045C>A	ENST00000252677.3	+	1	262	c.262C>A	c.(262-264)Cgc>Agc	p.R88S		NM_005448.2	NP_005439.2	O95972	BMP15_HUMAN	bone morphogenetic protein 15	88					female gamete generation|granulosa cell development|ovarian follicle development	extracellular space	cytokine activity|growth factor activity			NS(1)|breast(2)|endometrium(4)|kidney(1)|large_intestine(5)|lung(10)|ovary(2)|skin(1)	26	Ovarian(276;0.236)					TAGAGAGAACCGCACCATTGG	0.597000													2	6					0.004672	0.00490585	1	1	0
ZNF134	7693	broad.mit.edu	37	19	58131686	58131686	+	Nonsense_Mutation	SNP	G	G	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr19:58131686G>T	ENST00000396161.5	+	3	509	c.199G>T	c.(199-201)Gaa>Taa	p.E67*	ZNF134_ENST00000597975.1_3'UTR	NM_003435.3	NP_003426.3	P52741	ZN134_HUMAN	zinc finger protein 134	67						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(3)|lung(3)|prostate(1)	11		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0265)		GCACCTGGATGAACACCAGGG	0.478000													10	105					0.00829132	0.00866021	1	1	0
LUZP4	51213	broad.mit.edu	37	X	114537984	114537984	+	Splice_Site	SNP	G	G	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chrX:114537984G>A	ENST00000371920.3	+	3	349		c.e3+1		LUZP4_ENST00000451986.2_Intron	NM_016383.3	NP_057467.1	Q9P127	LUZP4_HUMAN	leucine zipper protein 4							nucleus				endometrium(1)|large_intestine(2)|lung(4)|ovary(2)|skin(3)|upper_aerodigestive_tract(2)	14						AATTGAGCAGGTAGATAAGTA	0.323000													13	47					0	0	1	0	0
EFCAB3	146779	broad.mit.edu	37	17	60491190	60491190	+	Missense_Mutation	SNP	C	C	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr17:60491190C>T	ENST00000450662.2	+	11	1192	c.1121C>T	c.(1120-1122)gCc>gTc	p.A374V	EFCAB3_ENST00000305286.3_Missense_Mutation_p.A322V	NM_001144933.1	NP_001138405.1	Q8N7B9	EFCB3_HUMAN	EF-hand calcium binding domain 3	322							calcium ion binding			cervix(1)|endometrium(2)|large_intestine(5)|lung(6)|skin(3)	17			BRCA - Breast invasive adenocarcinoma(2;2.27e-11)			TGTACAGTGGCCGATGCAACT	0.378000													10	65					0	0	1	0	0
SLC38A10	124565	broad.mit.edu	37	17	79263600	79263600	+	Silent	SNP	G	G	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr17:79263600G>A	ENST00000374759.3	-	2	491	c.108C>T	c.(106-108)atC>atT	p.I36I	SLC38A10_ENST00000288439.5_Silent_p.I36I	NM_001037984.1	NP_001033073.1	Q9HBR0	S38AA_HUMAN	solute carrier family 38, member 10	36					amino acid transport|sodium ion transport	integral to membrane				NS(1)|breast(2)|endometrium(4)|kidney(2)|large_intestine(2)|lung(7)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	23	all_neural(118;0.0804)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0272)|OV - Ovarian serous cystadenocarcinoma(97;0.117)			CCCCCAGGACGATGCCGCACT	0.617000													4	18					0	0	1	0	0
L3MBTL4	91133	broad.mit.edu	37	18	6093376	6093376	+	Missense_Mutation	SNP	C	C	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr18:6093376C>T	ENST00000400104.3	-	15	1551	c.1351G>A	c.(1351-1353)Gaa>Aaa	p.E451K	L3MBTL4_ENST00000535782.1_Missense_Mutation_p.E264K|L3MBTL4_ENST00000400105.2_Missense_Mutation_p.E451K|L3MBTL4_ENST00000284898.6_Missense_Mutation_p.E451K|L3MBTL4_ENST00000317931.7_Missense_Mutation_p.E451K			Q8NA19	LMBL4_HUMAN	l(3)mbt-like 4 (Drosophila)	451					chromatin modification	nucleus	sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(17)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	39		Colorectal(10;0.0249)				TTCACCTTTTCATGTTTTCCA	0.338000													10	73					0	0	1	0	0
MKRN3	7681	broad.mit.edu	37	15	23811208	23811208	+	Silent	SNP	C	C	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr15:23811208C>A	ENST00000314520.3	+	1	755	c.279C>A	c.(277-279)ggC>ggA	p.G93G	MKRN3_ENST00000564592.1_Silent_p.G93G|MKRN3_ENST00000568252.1_Silent_p.G93G	NM_005664.3	NP_005655.1	Q13064	MKRN3_HUMAN	makorin ring finger protein 3	93						ribonucleoprotein complex	ligase activity|nucleic acid binding|zinc ion binding			breast(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(33)|ovary(2)|prostate(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	61		all_cancers(20;8.44e-25)|all_epithelial(15;3.69e-22)|Lung NSC(15;2.96e-18)|all_lung(15;2.8e-17)|Breast(32;0.000353)|Colorectal(260;0.14)		all cancers(64;3.02e-06)|Epithelial(43;1.94e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0012)		GAAGCAGCGGCATTTGGACAA	0.597000													11	61					1.08611e-07	1.33197e-07	1	1	0
ANKRD36BP2	645784	broad.mit.edu	37	2	89084372	89084372	+	RNA	SNP	C	C	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr2:89084372C>T	ENST00000393525.3	+	0	740																											CTTCTCTTCCCCGAATAaatc	0.423000													3	3					0	0	1	0	0
PDZRN4	29951	broad.mit.edu	37	12	41966167	41966167	+	Splice_Site	SNP	C	C	G			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr12:41966167C>G	ENST00000298919.7	+	10	1194	c.804_splice	c.e10-1	p.P269_splice	PDZRN4_ENST00000402685.2_Splice_Site_p.P529_splice|PDZRN4_ENST00000539469.2_Splice_Site_p.P271_splice			Q6ZMN7	PZRN4_HUMAN	PDZ domain containing ring finger 4	529	PDZ 1.						ubiquitin-protein ligase activity|zinc ion binding			breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(23)|lung(29)|ovary(3)|pancreas(1)|prostate(2)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	77	all_cancers(12;0.000673)	Lung NSC(34;0.0205)|all_lung(34;0.0264)				TTTTCTTAGCCAAAAAAGCAA	0.358000													8	54					0	0	1	0	0
LRRC37A6P	387646	broad.mit.edu	37	10	27538569	27538569	+	RNA	SNP	G	G	A	rs11015624	by1000genomes	TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr10:27538569G>A	ENST00000574842.1	+	0	255				LRRC37A6P_ENST00000284414.4_RNA																							CAGGTCCAAAGGTTGAACTGT	0.478000													10	187					0	0	1	0	0
OLAH	55301	broad.mit.edu	37	10	15107592	15107592	+	Missense_Mutation	SNP	T	T	C			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr10:15107592T>C	ENST00000378217.3	+	7	758	c.571T>C	c.(571-573)Tgg>Cgg	p.W191R	OLAH_ENST00000378228.3_Missense_Mutation_p.W138R|OLAH_ENST00000485251.1_3'UTR	NM_018324.2	NP_060794.1	Q9NV23	SAST_HUMAN	oleoyl-ACP hydrolase	138					fatty acid biosynthetic process		myristoyl-[acyl-carrier-protein] hydrolase activity|oleoyl-[acyl-carrier-protein] hydrolase activity|palmitoyl-[acyl-carrier-protein] hydrolase activity			endometrium(2)|large_intestine(1)|lung(14)|stomach(1)	18						GTCAAAGGCCTGGCATCGCAT	0.398000													12	31					0	0	1	0	0
CUL9	23113	broad.mit.edu	37	6	43155093	43155093	+	Missense_Mutation	SNP	G	G	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr6:43155093G>T	ENST00000252050.4	+	6	1581	c.1497G>T	c.(1495-1497)tgG>tgT	p.W499C	CUL9_ENST00000354495.3_Intron|CUL9_ENST00000372647.2_Missense_Mutation_p.W499C	NM_015089.2	NP_055904.1	Q8IWT3	CUL9_HUMAN	cullin 9	499					ubiquitin-dependent protein catabolic process	cullin-RING ubiquitin ligase complex|cytoplasm	ATP binding|ubiquitin protein ligase binding|zinc ion binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|liver(1)|lung(30)|ovary(5)|prostate(3)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(4)	92						AGGCTGAATGGTGGGAGCTGC	0.488000													13	118					7.93312e-07	9.43553e-07	1	1	0
DUOX2	50506	broad.mit.edu	37	15	45389463	45389463	+	Missense_Mutation	SNP	C	C	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr15:45389463C>T	ENST00000389039.6	-	29	4205	c.3820G>A	c.(3820-3822)Gtg>Atg	p.V1274M	DUOX2_ENST00000603300.1_Missense_Mutation_p.V1274M			Q9NRD8	DUOX2_HUMAN	dual oxidase 2	1274	FAD-binding FR-type.				cuticle development|cytokine-mediated signaling pathway|hormone biosynthetic process|hydrogen peroxide catabolic process|response to cAMP|response to virus	apical plasma membrane|integral to membrane	calcium ion binding|electron carrier activity|flavin adenine dinucleotide binding|heme binding|NAD(P)H oxidase activity|peroxidase activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(28)|ovary(3)|pancreas(1)|prostate(4)|skin(7)|urinary_tract(1)	63		all_cancers(109;3.79e-11)|all_epithelial(112;2.92e-09)|Lung NSC(122;3.55e-06)|all_lung(180;2.56e-05)|Melanoma(134;0.027)		all cancers(107;1.05e-18)|GBM - Glioblastoma multiforme(94;4.23e-07)|COAD - Colon adenocarcinoma(120;0.0668)|Colorectal(133;0.068)		GCCTTCACCACGCTGATCTCC	0.587000													18	76					0	0	1	0	0
LGALS14	56891	broad.mit.edu	37	19	40197922	40197922	+	Missense_Mutation	SNP	G	G	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr19:40197922G>T	ENST00000392052.3	+	3	420	c.197G>T	c.(196-198)aGt>aTt	p.S66I	LGALS14_ENST00000360675.3_Missense_Mutation_p.S95I	NM_020129.2	NP_064514.1	Q8TCE9	PPL13_HUMAN	lectin, galactoside-binding, soluble, 14	66	Galectin.					nucleus	sugar binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(2)|ovary(1)|skin(2)|stomach(2)	14	all_cancers(60;4.39e-06)|all_lung(34;6.76e-08)|Lung NSC(34;7.98e-08)|Ovarian(47;0.06)	Myeloproliferative disorder(2;0.0741)	Epithelial(26;1.08e-24)|OV - Ovarian serous cystadenocarcinoma(5;1.92e-24)|all cancers(26;4.12e-22)			ATCATGAACAGTTGTGTGTTT	0.443000													120	134					3.18757e-65	4.93398e-65	1	1	0
C1orf168	199920	broad.mit.edu	37	1	57192183	57192183	+	Nonsense_Mutation	SNP	C	C	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr1:57192183C>A	ENST00000343433.6	-	16	1947	c.1867G>T	c.(1867-1869)Gaa>Taa	p.E623*		NM_001004303.4	NP_001004303.3	Q5VWT5	CA168_HUMAN	chromosome 1 open reading frame 168	623										NS(1)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(10)|lung(13)|ovary(3)|skin(6)|stomach(1)|urinary_tract(2)	46						TCTGATTCTTCAGCACCGTTT	0.378000													13	53					1.49906e-05	1.70875e-05	1	1	0
RAD51	5888	broad.mit.edu	37	15	40990990	40990990	+	Missense_Mutation	SNP	G	G	C			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr15:40990990G>C	ENST00000267868.3	+	2	302	c.34G>C	c.(34-36)Gat>Cat	p.D12H	RAD51_ENST00000382643.3_Missense_Mutation_p.D12H|RAD51_ENST00000423169.2_Missense_Mutation_p.D12H|RAD51_ENST00000557850.1_Missense_Mutation_p.D12H|RAD51_ENST00000532743.1_Missense_Mutation_p.D12H	NM_002875.4	NP_002866.2	Q06609	RAD51_HUMAN	RAD51 recombinase	12					DNA recombinase assembly|DNA unwinding involved in replication|mitotic recombination|positive regulation of DNA ligation|protein homooligomerization|reciprocal meiotic recombination	mitochondrial matrix|nucleus|perinuclear region of cytoplasm|PML body	ATP binding|damaged DNA binding|double-stranded DNA binding|identical protein binding|protein C-terminus binding|single-stranded DNA binding|single-stranded DNA-dependent ATPase activity			breast(2)|endometrium(1)|kidney(3)|large_intestine(1)|lung(1)|ovary(1)	9		all_cancers(109;1.19e-18)|all_epithelial(112;2.33e-15)|Lung NSC(122;5.34e-11)|all_lung(180;1.33e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.0946)		GBM - Glioblastoma multiforme(113;1.45e-05)|BRCA - Breast invasive adenocarcinoma(123;0.000421)|COAD - Colon adenocarcinoma(120;0.163)		AGCAAATGCAGATACTTCAGT	0.378000								Homologous recombination					7	60					0	0	1	0	0
INSRR	3645	broad.mit.edu	37	1	156824049	156824049	+	Missense_Mutation	SNP	C	C	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr1:156824049C>A	ENST00000368195.3	-	2	528	c.132G>T	c.(130-132)caG>caT	p.Q44H	NTRK1_ENST00000392302.2_Intron	NM_014215.2	NP_055030.1	P14616	INSRR_HUMAN	insulin receptor-related receptor	44					protein autophosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|insulin receptor substrate binding|metal ion binding|phosphatidylinositol 3-kinase binding|transmembrane receptor protein tyrosine kinase activity			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(13)|ovary(7)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)	42	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					AGTTCTCCAGCTGACGAAGCT	0.622000													6	48					3.59834e-05	4.04556e-05	1	1	0
DNAH17	8632	broad.mit.edu	37	17	76487572	76487572	+	Missense_Mutation	SNP	C	C	G			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr17:76487572C>G	ENST00000389840.5	-	43	6704	c.6580G>C	c.(6580-6582)Gac>Cac	p.D2194H	RP11-559N14.5_ENST00000585969.1_RNA|DNAH17_ENST00000586052.1_5'UTR|DNAH17_ENST00000585328.1_Missense_Mutation_p.D2203H					dynein, axonemal, heavy chain 17											NS(2)|breast(7)|central_nervous_system(5)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(13)|large_intestine(8)|lung(37)|ovary(8)|prostate(7)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	116			BRCA - Breast invasive adenocarcinoma(99;0.00294)|OV - Ovarian serous cystadenocarcinoma(97;0.0656)			CACATGGGGTCTATGTCTCCG	0.592000													4	14					0	0	1	0	0
OR2W5	441932	broad.mit.edu	37	1	247655050	247655050	+	RNA	SNP	T	T	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr1:247655050T>A	ENST00000522351.1	+	0	681							A6NFC9	OR2W5_HUMAN							sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(5)|kidney(2)|large_intestine(2)|lung(24)|ovary(1)|skin(4)	39	all_cancers(71;4.51e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.222)	OV - Ovarian serous cystadenocarcinoma(106;0.0188)			GTGGCTCTCCTCCTGGTGCCG	0.567000													23	132					0	0	1	0	0
MAP10	54627	broad.mit.edu	37	1	232941054	232941054	+	Missense_Mutation	SNP	C	C	G			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr1:232941054C>G	ENST00000418460.1	+	1	412	c.285C>G	c.(283-285)caC>caG	p.H95Q		NM_019090.2	NP_061963.2			microtubule-associated protein 10																		AAAGCAGACACCGCCCGAGAC	0.537000													15	99					0	0	1	0	0
PLCXD3	345557	broad.mit.edu	37	5	41381976	41381976	+	Missense_Mutation	SNP	G	G	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr5:41381976G>T	ENST00000377801.3	-	2	838	c.764C>A	c.(763-765)aCt>aAt	p.T255N	PLCXD3_ENST00000328457.3_Missense_Mutation_p.T255N			Q63HM9	PLCX3_HUMAN	phosphatidylinositol-specific phospholipase C, X domain containing 3	255					intracellular signal transduction|lipid catabolic process		phospholipase C activity|signal transducer activity			central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(4)|lung(21)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	37						TTTGACCACAGTGCTAGCTTT	0.433000													27	114					1.17739e-12	1.61237e-12	1	1	0
OR5AS1	219447	broad.mit.edu	37	11	55798643	55798643	+	Nonsense_Mutation	SNP	T	T	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr11:55798643T>A	ENST00000313555.1	+	1	749	c.749T>A	c.(748-750)tTa>tAa	p.L250*		NM_001001921.1	NP_001001921.1	Q8N127	O5AS1_HUMAN	olfactory receptor, family 5, subfamily AS, member 1	250					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(7)|large_intestine(7)|liver(1)|lung(22)|ovary(3)|prostate(4)|skin(3)|stomach(1)	48	Esophageal squamous(21;0.00693)					GCAGTCACCTTATTCTATGGA	0.458000													14	79					0	0	1	0	0
CSNK1D	1453	broad.mit.edu	37	17	80231184	80231184	+	Missense_Mutation	SNP	A	A	G			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr17:80231184A>G	ENST00000314028.6	-	1	423	c.74T>C	c.(73-75)cTc>cCc	p.L25P	CSNK1D_ENST00000398519.5_Missense_Mutation_p.L25P|CSNK1D_ENST00000392334.2_Missense_Mutation_p.L25P	NM_001893.4	NP_001884.2	P48730	KC1D_HUMAN	casein kinase 1, delta	25	Protein kinase.				circadian regulation of gene expression|DNA repair|G2/M transition of mitotic cell cycle|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|regulation of circadian rhythm|Wnt receptor signaling pathway	centrosome|cytosol|nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			breast(2)|large_intestine(2)|lung(7)	11	Breast(20;0.00136)|all_neural(118;0.0804)|Lung NSC(278;0.128)|all_lung(278;0.145)|Ovarian(332;0.227)		OV - Ovarian serous cystadenocarcinoma(97;0.00463)|BRCA - Breast invasive adenocarcinoma(99;0.0155)			ggccTCACCGAGATAGATGTC	0.731000													5	25					0	0	1	0	0
CACNA1E	777	broad.mit.edu	37	1	181480507	181480507	+	Splice_Site	SNP	G	G	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr1:181480507G>T	ENST00000526775.1	+	3	538	c.372_splice	c.e3-1	p.E125_splice	CACNA1E_ENST00000357570.5_Splice_Site_p.E76_splice|CACNA1E_ENST00000358338.5_Splice_Site_p.E76_splice|CACNA1E_ENST00000367570.1_Splice_Site_p.E125_splice|CACNA1E_ENST00000360108.3_Splice_Site_p.E125_splice|CACNA1E_ENST00000367573.2_Splice_Site_p.E125_splice|CACNA1E_ENST00000367567.4_5'UTR	NM_001205294.1	NP_001192223.1	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type, alpha 1E subunit	125					energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			NS(2)|breast(9)|central_nervous_system(3)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(6)|kidney(4)|large_intestine(34)|lung(99)|ovary(6)|pancreas(1)|prostate(9)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	204						ATCCCCACAGGAGAAGACAGA	0.507000													36	240					9.04072e-19	1.32454e-18	1	1	0
CARD6	84674	broad.mit.edu	37	5	40843532	40843532	+	Missense_Mutation	SNP	C	C	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr5:40843532C>A	ENST00000254691.5	+	2	761	c.562C>A	c.(562-564)Cca>Aca	p.P188T	CARD6_ENST00000381677.3_Missense_Mutation_p.P188T	NM_032587.3	NP_115976.2	Q9BX69	CARD6_HUMAN	caspase recruitment domain family, member 6	188					apoptosis|regulation of apoptosis	intracellular				NS(1)|breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|liver(2)|lung(29)|ovary(2)|pancreas(1)|prostate(2)|skin(3)|urinary_tract(1)	62						ATGTGAAGTTCCAGCAACTAT	0.373000													12	55					3.07112e-06	3.59634e-06	1	1	0
EPHA3	2042	broad.mit.edu	37	3	89499488	89499488	+	Silent	SNP	C	C	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr3:89499488C>A	ENST00000336596.2	+	15	2883	c.2658C>A	c.(2656-2658)ggC>ggA	p.G886G	EPHA3_ENST00000494014.1_Silent_p.G886G	NM_005233.5	NP_005224.2	P29320	EPHA3_HUMAN	EPH receptor A3	886						extracellular region|integral to plasma membrane	ATP binding			NS(1)|breast(4)|central_nervous_system(4)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(26)|liver(3)|lung(67)|ovary(7)|pancreas(1)|prostate(4)|skin(8)|stomach(1)|upper_aerodigestive_tract(5)	139	all_cancers(8;0.0406)|Melanoma(1;0.00142)|all_epithelial(1;0.0612)	Lung NSC(201;0.0782)		LUSC - Lung squamous cell carcinoma(29;0.00344)|Lung(72;0.00942)		GGAATCCCGGCAGCCTGAAGA	0.448000										TSP Lung(6;0.00050)			7	80					2.7689e-08	3.49569e-08	1	1	0
RANBP2	5903	broad.mit.edu	37	2	109383078	109383078	+	Missense_Mutation	SNP	G	G	C			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr2:109383078G>C	ENST00000283195.6	+	20	6209	c.6083G>C	c.(6082-6084)gGa>gCa	p.G2028A		NM_006267.4	NP_006258.3	P49792	RBP2_HUMAN	RAN binding protein 2	2028	RanBD1 2.				carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA transport|protein folding|protein import into nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear pore	peptidyl-prolyl cis-trans isomerase activity|Ran GTPase binding|zinc ion binding		RANBP2/ALK(34)	NS(1)|biliary_tract(1)|breast(3)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(21)|large_intestine(19)|lung(51)|pancreas(1)|prostate(8)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(1)	129						CTTGTAACAGGAGAAGAAGAT	0.393000													93	436					0	0	1	0	0
GPR113	165082	broad.mit.edu	37	2	26536638	26536638	+	Silent	SNP	G	G	C			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr2:26536638G>C	ENST00000333478.6	-	5	1251	c.669C>G	c.(667-669)acC>acG	p.T223T	GPR113_ENST00000459892.1_5'UTR|GPR113_ENST00000541401.1_Silent_p.T25T|GPR113_ENST00000311519.1_Silent_p.T422T|GPR113_ENST00000421160.2_Silent_p.T353T	NM_153835.3	NP_722577.2	Q8IZF5	GP113_HUMAN	G protein-coupled receptor 113	422					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(5)|ovary(4)|prostate(2)|skin(1)|stomach(1)|urinary_tract(1)	24	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CCTGGATGATGGTGATGGAGA	0.652000													8	49					0	0	1	0	0
SCN10A	6336	broad.mit.edu	37	3	38763885	38763885	+	Missense_Mutation	SNP	G	G	A	rs143208505		TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr3:38763885G>A	ENST00000449082.2	-	19	3370	c.3371C>T	c.(3370-3372)cCc>cTc	p.P1124L		NM_006514.2	NP_006505.2	Q9Y5Y9	SCNAA_HUMAN	sodium channel, voltage-gated, type X, alpha subunit	1124					sensory perception	voltage-gated sodium channel complex				NS(5)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(14)|kidney(5)|large_intestine(33)|lung(54)|ovary(5)|pancreas(1)|prostate(5)|skin(13)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	150				KIRC - Kidney renal clear cell carcinoma(284;0.0769)|Kidney(284;0.0945)	Benzocaine(DB01086)|Bupivacaine(DB00297)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dibucaine(DB00527)|Dyclonine(DB00645)|Hexylcaine(DB00473)|Levobupivacaine(DB01002)|Lidocaine(DB00281)|Mepivacaine(DB00961)|Oxybuprocaine(DB00892)|Procaine(DB00721)|Proparacaine(DB00807)|Ropivacaine(DB00296)	TTTGCAGCAGGGACAGTGGCG	0.557000													18	98					0	0	1	0	0
OR2W3	343171	broad.mit.edu	37	1	248059735	248059735	+	Missense_Mutation	SNP	C	C	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr1:248059735C>A	ENST00000537741.1	+	3	1104	c.847C>A	c.(847-849)Ccc>Acc	p.P283T	OR2W3_ENST00000360358.3_Missense_Mutation_p.P283T			Q7Z3T1	OR2W3_HUMAN	olfactory receptor, family 2, subfamily W, member 3	283					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|kidney(2)|large_intestine(2)|lung(33)|ovary(1)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(3)	49	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0319)			CATTGTCACCCCCCTCCTCAA	0.507000													40	49					2.87052e-16	4.11984e-16	1	1	0
OASL	8638	broad.mit.edu	37	12	121465410	121465410	+	Missense_Mutation	SNP	C	C	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr12:121465410C>A	ENST00000257570.5	-	4	1138	c.868G>T	c.(868-870)Gat>Tat	p.D290Y	OASL_ENST00000339275.5_Intron	NM_003733.3	NP_003724.1	Q15646	OASL_HUMAN	2'-5'-oligoadenylate synthetase-like	290					interferon-gamma-mediated signaling pathway|type I interferon-mediated signaling pathway	cytoplasm|nucleolus	ATP binding|DNA binding|double-stranded RNA binding|thyroid hormone receptor binding|transferase activity			NS(1)|endometrium(3)|large_intestine(4)|lung(4)|skin(2)	14	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)					CTGACACAATCCTCAATGATT	0.458000													9	81					6.71089e-19	9.8613e-19	1	1	0
TOP1MT	116447	broad.mit.edu	37	8	144391652	144391652	+	Missense_Mutation	SNP	C	C	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr8:144391652C>T	ENST00000523676.1	-	15	1876	c.1471G>A	c.(1471-1473)Gcc>Acc	p.A491T	TOP1MT_ENST00000519148.1_Missense_Mutation_p.A491T|TOP1MT_ENST00000329245.4_Missense_Mutation_p.A589T|TOP1MT_ENST00000521193.1_Missense_Mutation_p.A491T			Q969P6	TOP1M_HUMAN	topoisomerase (DNA) I, mitochondrial	589					DNA topological change	chromosome|mitochondrial nucleoid	ATP binding|chromatin DNA binding|DNA topoisomerase (ATP-hydrolyzing) activity|DNA topoisomerase type I activity			endometrium(5)|kidney(1)|large_intestine(6)|lung(8)|ovary(1)|upper_aerodigestive_tract(2)	23	all_cancers(97;1.01e-10)|all_epithelial(106;4.86e-09)|Lung NSC(106;0.000167)|all_lung(105;0.000459)|Ovarian(258;0.0212)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.156)|Colorectal(110;0.173)		Irinotecan(DB00762)|Topotecan(DB01030)	AGAGCCCAGGCGAACCTCTCC	0.517000													16	59					0	0	1	0	0
SCN9A	6335	broad.mit.edu	37	2	167134813	167134813	+	Missense_Mutation	SNP	C	C	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr2:167134813C>A	ENST00000375387.4	-	15	2697	c.2357G>T	c.(2356-2358)gGa>gTa	p.G786V	SCN9A_ENST00000409435.1_Missense_Mutation_p.G785V|AC010127.3_ENST00000447809.2_RNA|SCN9A_ENST00000303354.6_Missense_Mutation_p.G786V|SCN9A_ENST00000409672.1_Missense_Mutation_p.G774V			Q15858	SCN9A_HUMAN	sodium channel, voltage-gated, type IX, alpha subunit	785						voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(1)|breast(5)|central_nervous_system(6)|endometrium(6)|kidney(3)|large_intestine(27)|lung(38)|ovary(6)|prostate(8)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	108					Lamotrigine(DB00555)|Lidocaine(DB00281)	TGCAAAGATTCCAGTAAAGAC	0.318000													4	16					0.150653	0.151731	1	1	0
C17orf78	284099	broad.mit.edu	37	17	35733081	35733081	+	Missense_Mutation	SNP	C	C	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr17:35733081C>A	ENST00000300618.4	+	1	97	c.47C>A	c.(46-48)gCc>gAc	p.A16D	ACACA_ENST00000353139.5_Intron|C17orf78_ENST00000586700.1_Missense_Mutation_p.A16D|ACACA_ENST00000416895.1_Intron	NM_173625.3	NP_775896.3	Q8N4C9	CQ078_HUMAN	chromosome 17 open reading frame 78	16						integral to membrane				NS(1)|endometrium(1)|large_intestine(1)|lung(2)|stomach(1)	6		Breast(25;0.00295)|Ovarian(249;0.15)				TCCTATGATGCCAACAAGAAA	0.453000													7	38					5.18039e-06	6.03767e-06	1	1	0
BARHL2	343472	broad.mit.edu	37	1	91180090	91180090	+	Silent	SNP	G	G	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr1:91180090G>T	ENST00000370445.4	-	2	890	c.849C>A	c.(847-849)cgC>cgA	p.R283R		NM_020063.1	NP_064447.1	Q9NY43	BARH2_HUMAN	BarH-like homeobox 2	283						nucleus	sequence-specific DNA binding			cervix(2)|endometrium(1)|kidney(3)|large_intestine(5)|lung(9)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	24		all_lung(203;0.0263)|Lung SC(238;0.128)		all cancers(265;0.000897)|Epithelial(280;0.00516)|OV - Ovarian serous cystadenocarcinoma(397;0.211)		TCCCTTACCTGCGGTTCTGGT	0.542000													13	150					0.00244969	0.00259441	1	1	0
VPS36	51028	broad.mit.edu	37	13	53010530	53010530	+	Missense_Mutation	SNP	T	T	C			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr13:53010530T>C	ENST00000378060.4	-	4	273	c.246A>G	c.(244-246)atA>atG	p.I82M	VPS36_ENST00000480923.1_5'UTR	NM_016075.2	NP_057159.2	Q86VN1	VPS36_HUMAN	vacuolar protein sorting 36 homolog (S. cerevisiae)	82	GLUE N-terminal.				cellular membrane organization|endosome transport|protein transport|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|late endosome|membrane|nucleus	lipid binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(7)|skin(1)|upper_aerodigestive_tract(2)	17		Breast(56;0.000207)|Lung NSC(96;0.00212)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;3.14e-08)		GATGAACCACTATTTTGGCAC	0.338000													3	7					0	0	1	0	0
UNC13C	440279	broad.mit.edu	37	15	54707184	54707184	+	Missense_Mutation	SNP	C	C	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr15:54707184C>A	ENST00000545554.1	+	18	4852	c.4852C>A	c.(4852-4854)Cct>Act	p.P1618T	UNC13C_ENST00000260323.11_Missense_Mutation_p.P1618T|UNC13C_ENST00000537900.1_Missense_Mutation_p.P1616T			Q8NB66	UN13C_HUMAN	unc-13 homolog C (C. elegans)	1618					exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			breast(3)|endometrium(5)|kidney(5)|large_intestine(20)|lung(70)|ovary(6)|pancreas(2)|prostate(2)|upper_aerodigestive_tract(4)|urinary_tract(4)	121				GBM - Glioblastoma multiforme(80;0.0789)|all cancers(107;0.124)		TTTTAGGTTTCCTCAAGAGCT	0.303000													3	22					0.115264	0.117045	1	1	0
ZNF230	7773	broad.mit.edu	37	19	44515430	44515430	+	Silent	SNP	C	C	G			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr19:44515430C>G	ENST00000429154.2	+	5	1467	c.1239C>G	c.(1237-1239)ctC>ctG	p.L413L		NM_006300.3	NP_006291.2	Q9UIE0	ZN230_HUMAN	zinc finger protein 230	413					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|endometrium(2)|large_intestine(2)|lung(10)|skin(1)|stomach(3)|urinary_tract(2)	22		Prostate(69;0.0352)				ATAAGAAACTCCACTGCCGGA	0.438000													14	91					0	0	1	0	0
CNR1	1268	broad.mit.edu	37	6	88854096	88854096	+	Nonsense_Mutation	SNP	T	T	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr6:88854096T>A	ENST00000537554.1	-	2	4460	c.898A>T	c.(898-900)Aag>Tag	p.K300*	CNR1_ENST00000535130.1_Nonsense_Mutation_p.K300*|CNR1_ENST00000362094.5_3'UTR|CNR1_ENST00000428600.2_Nonsense_Mutation_p.K300*|CNR1_ENST00000369501.2_Nonsense_Mutation_p.K300*|CNR1_ENST00000549716.1_Nonsense_Mutation_p.K239*|CNR1_ENST00000468898.1_Nonsense_Mutation_p.K267*|CNR1_ENST00000549890.1_Nonsense_Mutation_p.K300*|CNR1_ENST00000369499.2_Nonsense_Mutation_p.K300*	NM_001160226.1|NM_001160258.1	NP_001153698.1|NP_001153730.1	P21554	CNR1_HUMAN	cannabinoid receptor 1 (brain)	300					G-protein signaling, coupled to cAMP nucleotide second messenger	integral to plasma membrane	cannabinoid receptor activity|protein binding			breast(2)|endometrium(3)|kidney(1)|large_intestine(7)|liver(1)|lung(11)|prostate(1)|skin(10)|urinary_tract(1)	37		all_cancers(76;8.24e-09)|Acute lymphoblastic leukemia(125;2.15e-10)|Prostate(29;4.11e-10)|all_hematologic(105;1.08e-06)|all_epithelial(107;0.00011)		BRCA - Breast invasive adenocarcinoma(108;0.15)	Marinol(DB00470)|Nabilone(DB00486)|Rimonabant(DB06155)	CTGTGAGCCTTCCAGAGAATA	0.527000													37	77					0	0	1	0	0
CCDC61	729440	broad.mit.edu	37	19	46511435	46511435	+	Missense_Mutation	SNP	C	C	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr19:46511435C>T	ENST00000263284.2	+	6	598	c.598C>T	c.(598-600)Cca>Tca	p.P200S	CCDC61_ENST00000594087.1_Missense_Mutation_p.P143S|CCDC61_ENST00000595358.1_Missense_Mutation_p.P143S|CCDC61_ENST00000536603.1_Missense_Mutation_p.P143S					coiled-coil domain containing 61											endometrium(3)|kidney(3)|large_intestine(1)|lung(5)|ovary(1)	13		all_neural(266;0.113)|Ovarian(192;0.127)		OV - Ovarian serous cystadenocarcinoma(262;0.00221)|GBM - Glioblastoma multiforme(486;0.0233)|Epithelial(262;0.164)		CCAGGGCAAGCCAGACCCCGT	0.607000													8	18					0	0	1	0	0
ATP2B3	492	broad.mit.edu	37	X	152806852	152806852	+	Missense_Mutation	SNP	A	A	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chrX:152806852A>T	ENST00000370186.1	+	3	570	c.244A>T	c.(244-246)Agg>Tgg	p.R82W	ATP2B3_ENST00000359149.3_Missense_Mutation_p.R82W|ATP2B3_ENST00000349466.2_Missense_Mutation_p.R82W|ATP2B3_ENST00000263519.4_Missense_Mutation_p.R82W|ATP2B3_ENST00000370181.2_Missense_Mutation_p.R82W|ATP2B3_ENST00000393842.1_Missense_Mutation_p.R82W			Q16720	AT2B3_HUMAN	ATPase, Ca++ transporting, plasma membrane 3	82					ATP biosynthetic process|platelet activation	integral to membrane|plasma membrane	ATP binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding			NS(2)|breast(5)|endometrium(7)|large_intestine(8)|lung(23)|ovary(1)|pancreas(1)|skin(3)	50	all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					GGAGAAGCGCAGGCAGATCTA	0.622000													13	22					0	0	1	0	0
CENPE	1062	broad.mit.edu	37	4	104070561	104070561	+	Missense_Mutation	SNP	T	T	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr4:104070561T>A	ENST00000265148.3	-	27	3490	c.3401A>T	c.(3400-3402)cAg>cTg	p.Q1134L	CENPE_ENST00000380026.3_Missense_Mutation_p.Q1109L	NM_001813.2	NP_001804.2	Q02224	CENPE_HUMAN	centromere protein E, 312kDa	1134					blood coagulation|cell division|kinetochore assembly|microtubule-based movement|mitotic chromosome movement towards spindle pole|mitotic metaphase|mitotic metaphase plate congression|mitotic prometaphase|multicellular organismal development|positive regulation of protein kinase activity	condensed chromosome kinetochore|cytosol|microtubule|nucleus|spindle	ATP binding|kinetochore binding|microtubule motor activity	p.Q1134L(1)		NS(3)|breast(6)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(20)|lung(34)|ovary(5)|pancreas(1)|prostate(2)|skin(3)|stomach(5)|urinary_tract(3)	101				OV - Ovarian serous cystadenocarcinoma(123;2.95e-08)		TTGGAGTTGCTGGCTCTTAAA	0.289000													5	16					0	0	1	0	0
CRNN	49860	broad.mit.edu	37	1	152382571	152382571	+	Silent	SNP	C	C	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr1:152382571C>T	ENST00000271835.3	-	3	1049	c.987G>A	c.(985-987)gaG>gaA	p.E329E	RP1-91G5.3_ENST00000411804.1_RNA	NM_016190.2	NP_057274.1	Q9UBG3	CRNN_HUMAN	cornulin	329	Gln-rich.				cell-cell adhesion|response to heat	cytoplasm|membrane	calcium ion binding			breast(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(16)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	35	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			GACCGTGGATCTCAGTCCCTC	0.602000													152	271					0	0	1	0	0
XIRP2	129446	broad.mit.edu	37	2	168106791	168106791	+	Missense_Mutation	SNP	G	G	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr2:168106791G>T	ENST00000409195.1	+	9	8978	c.8889G>T	c.(8887-8889)caG>caT	p.Q2963H	XIRP2_ENST00000409043.1_Intron|XIRP2_ENST00000409605.1_Intron|XIRP2_ENST00000295237.9_Missense_Mutation_p.Q2963H|XIRP2_ENST00000420519.1_Intron|XIRP2_ENST00000409273.1_Missense_Mutation_p.Q2741H|XIRP2_ENST00000409728.1_Intron|XIRP2_ENST00000409756.2_Intron	NM_152381.5	NP_689594.4	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2	2788					actin cytoskeleton organization	cell junction	actin binding			NS(3)|biliary_tract(2)|breast(5)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(51)|lung(160)|ovary(7)|pancreas(3)|prostate(11)|skin(14)|stomach(5)|upper_aerodigestive_tract(8)|urinary_tract(7)	315						GAGTGAAACAGTTTGAAGCAG	0.383000													10	99					1.76689e-08	2.2364e-08	1	1	0
GALNT8	26290	broad.mit.edu	37	12	4854759	4854759	+	Missense_Mutation	SNP	G	G	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr12:4854759G>T	ENST00000252318.2	+	5	1362	c.1025G>T	c.(1024-1026)tGg>tTg	p.W342L		NM_017417.1	NP_059113.1	Q9NY28	GALT8_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 8 (GalNAc-T8)	342						Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(13)|ovary(2)|pancreas(1)|prostate(4)|skin(2)|urinary_tract(1)	35						CCACAAGCCTGGATTGATCTG	0.468000													13	25					4.36969e-10	5.70664e-10	1	1	0
MUC5B	727897	broad.mit.edu	37	11	1272350	1272350	+	Missense_Mutation	SNP	C	C	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr11:1272350C>A	ENST00000447027.1	+	31	14307	c.14249C>A	c.(14248-14250)gCt>gAt	p.A4750D	MUC5B_ENST00000529681.1_Missense_Mutation_p.A4747D			Q9HC84	MUC5B_HUMAN	mucin 5B, oligomeric mucus/gel-forming	4747	23 X approximate tandem repeats, Ser/Thr- rich.|Thr-rich.				cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding			cervix(2)|endometrium(36)|kidney(9)|lung(89)|urinary_tract(1)	137		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		AAATCCACAGCTACCAGCTTT	0.592000													18	65					1.33834e-09	1.72949e-09	1	1	0
SMC3	9126	broad.mit.edu	37	10	112361869	112361869	+	Missense_Mutation	SNP	C	C	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr10:112361869C>T	ENST00000361804.4	+	25	3164	c.3038C>T	c.(3037-3039)tCa>tTa	p.S1013L		NM_005445.3	NP_005436.1	Q9UQE7	SMC3_HUMAN	structural maintenance of chromosomes 3	1013					cell division|DNA mediated transformation|DNA repair|meiosis|mitotic metaphase/anaphase transition|mitotic prometaphase|mitotic spindle organization|negative regulation of DNA endoreduplication|signal transduction|sister chromatid cohesion	basement membrane|chromatin|chromosome, centromeric region|cytoplasm|meiotic cohesin complex|nuclear matrix|nucleoplasm|spindle pole	ATP binding|dynein binding|microtubule motor activity|protein heterodimerization activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|large_intestine(5)|lung(13)|ovary(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	39		Breast(234;0.0848)|Lung NSC(174;0.238)		Epithelial(162;0.00206)|all cancers(201;0.0227)|BRCA - Breast invasive adenocarcinoma(275;0.127)		GGTTACAAATCAATCATGGAA	0.343000													16	58					0	0	1	0	0
LGALS13	29124	broad.mit.edu	37	19	40096020	40096020	+	Missense_Mutation	SNP	G	G	C			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr19:40096020G>C	ENST00000221797.4	+	3	340	c.295G>C	c.(295-297)Gag>Cag	p.E99Q		NM_013268.2	NP_037400.1	Q9UHV8	PP13_HUMAN	lectin, galactoside-binding, soluble, 13	99	Galectin.				lipid catabolic process|phospholipid metabolic process		carboxylesterase activity|lysophospholipase activity|sugar binding			lung(5)|ovary(1)|urinary_tract(1)	7	all_cancers(60;1.77e-05)|all_lung(34;5.38e-08)|Lung NSC(34;6.37e-08)|Ovarian(47;0.116)		Epithelial(26;3.28e-26)|OV - Ovarian serous cystadenocarcinoma(5;7.31e-25)|all cancers(26;1.15e-23)|LUSC - Lung squamous cell carcinoma(53;0.00281)			ACATTACAATGAGTATGAGGT	0.527000													11	38					0	0	1	0	0
PNMAL1	55228	broad.mit.edu	37	19	46972992	46972992	+	Missense_Mutation	SNP	T	T	C			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr19:46972992T>C	ENST00000313683.10	-	2	1606	c.1301A>G	c.(1300-1302)aAt>aGt	p.N434S	PNMAL1_ENST00000602246.1_Intron|PNMAL1_ENST00000438932.2_Intron	NM_001103149.1|NM_018215.3	NP_001096619.1|NP_060685.2	Q86V59	PNML1_HUMAN	paraneoplastic Ma antigen family-like 1	434										cervix(1)|endometrium(2)|large_intestine(8)|lung(8)|prostate(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	25		Ovarian(192;0.00965)|all_neural(266;0.0459)		OV - Ovarian serous cystadenocarcinoma(262;0.000166)|all cancers(93;0.0014)|GBM - Glioblastoma multiforme(486;0.0421)|Epithelial(262;0.0427)		ATTCTCACCATTGGTGGCACG	0.642000													19	28					0	0	1	0	0
TNN	63923	broad.mit.edu	37	1	175049360	175049360	+	Missense_Mutation	SNP	G	G	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr1:175049360G>T	ENST00000239462.4	+	4	959	c.846G>T	c.(844-846)tgG>tgT	p.W282C		NM_022093.1	NP_071376.1	Q9UQP3	TENN_HUMAN	tenascin N	282	Fibronectin type-III 1.				cell growth|cell migration|signal transduction	extracellular space|proteinaceous extracellular matrix				NS(1)|central_nervous_system(2)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(29)|liver(1)|lung(81)|ovary(5)|prostate(6)|skin(5)|stomach(4)|upper_aerodigestive_tract(3)|urinary_tract(3)	156		Breast(1374;0.000962)		KIRC - Kidney renal clear cell carcinoma(1967;0.00198)		TGGTGAGCTGGGAGCCCTCCA	0.607000													24	36					2.39556e-15	3.39372e-15	1	1	0
KIAA1109	84162	broad.mit.edu	37	4	123277817	123277817	+	Missense_Mutation	SNP	G	G	C			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr4:123277817G>C	ENST00000264501.4	+	84	14915	c.14542G>C	c.(14542-14544)Gag>Cag	p.E4848Q	KIAA1109_ENST00000388738.3_Missense_Mutation_p.E4848Q			Q2LD37	K1109_HUMAN	KIAA1109	4848					regulation of cell growth|regulation of epithelial cell differentiation	integral to membrane|nucleus				breast(7)|central_nervous_system(1)|cervix(1)|endometrium(16)|kidney(6)|large_intestine(33)|liver(4)|lung(74)|ovary(9)|pancreas(1)|prostate(5)|skin(6)|upper_aerodigestive_tract(6)|urinary_tract(3)	172						TGTGGTGACAGAGTTCACTGA	0.358000													12	79					0	0	1	0	0
SLC18A2	6571	broad.mit.edu	37	10	119003664	119003664	+	Missense_Mutation	SNP	G	G	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr10:119003664G>T	ENST00000298472.5	+	3	447	c.304G>T	c.(304-306)Gcc>Tcc	p.A102S	SLC18A2_ENST00000497497.1_3'UTR	NM_003054.4	NP_003045.2	Q05940	VMAT2_HUMAN	solute carrier family 18 (vesicular monoamine transporter), member 2	102					neurotransmitter secretion	clathrin sculpted monoamine transport vesicle membrane|integral to plasma membrane|membrane fraction	monoamine transmembrane transporter activity			NS(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(8)|lung(16)	29		Colorectal(252;0.19)		all cancers(201;0.029)	Alseroxylon(DB00386)|Reserpine(DB00206)|Tetrabenazine(DB04844)	TCATCAGACCGCCACACAGCA	0.507000													13	69					4.3838e-07	5.26483e-07	1	1	0
RASGRP4	115727	broad.mit.edu	37	19	38912679	38912679	+	Missense_Mutation	SNP	C	C	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr19:38912679C>A	ENST00000454404.2	-	2	351	c.138G>T	c.(136-138)atG>atT	p.M46I	RASGRP4_ENST00000586305.1_Missense_Mutation_p.M46I|RASGRP4_ENST00000293062.9_Missense_Mutation_p.M46I|RASGRP4_ENST00000426920.2_Missense_Mutation_p.M46I|RASGRP4_ENST00000587753.1_Missense_Mutation_p.M46I|RASGRP4_ENST00000587738.1_Missense_Mutation_p.M46I|RASGRP4_ENST00000433821.2_Missense_Mutation_p.M46I	NM_001146205.1|NM_170604.2	NP_001139677.1|NP_733749.1	Q8TDF6	GRP4_HUMAN	RAS guanyl releasing protein 4	46					activation of phospholipase C activity|cell growth|cell proliferation|myeloid cell differentiation|positive regulation of Ras protein signal transduction|regulation of G-protein coupled receptor protein signaling pathway|response to extracellular stimulus|small GTPase mediated signal transduction|transmembrane receptor protein tyrosine kinase signaling pathway	cytoplasm|membrane fraction|plasma membrane|soluble fraction	diacylglycerol binding|GTP-dependent protein binding|metal ion binding|Ras guanyl-nucleotide exchange factor activity			cervix(1)|kidney(1)|large_intestine(4)|lung(12)|pancreas(1)|prostate(3)|skin(1)	23	all_cancers(60;4.21e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)			GGCCCAGGTTCATGGAAGCCA	0.617000													4	32					0.150653	0.151731	1	1	0
PHF20	51230	broad.mit.edu	37	20	34487415	34487415	+	Nonsense_Mutation	SNP	T	T	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr20:34487415T>A	ENST00000374012.3	+	10	1535	c.1406T>A	c.(1405-1407)tTg>tAg	p.L469*	PHF20_ENST00000481202.1_3'UTR|PHF20_ENST00000439301.1_3'UTR			Q9BVI0	PHF20_HUMAN	PHD finger protein 20	469					regulation of transcription, DNA-dependent|transcription, DNA-dependent	MLL1 complex	DNA binding|zinc ion binding			breast(5)|endometrium(1)|kidney(7)|large_intestine(6)|lung(11)|ovary(3)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	39	Breast(12;0.00631)|all_lung(11;0.0145)					GCCAAACTGTTGCACTATCAC	0.458000													8	43					0	0	1	0	0
SLC8A3	6547	broad.mit.edu	37	14	70634985	70634985	+	Nonsense_Mutation	SNP	G	G	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr14:70634985G>T	ENST00000381269.2	-	2	908	c.155C>A	c.(154-156)tCg>tAg	p.S52*	SLC8A3_ENST00000534137.1_Nonsense_Mutation_p.S52*|SLC8A3_ENST00000528359.1_Nonsense_Mutation_p.S52*|SLC8A3_ENST00000356921.2_Nonsense_Mutation_p.S52*|SLC8A3_ENST00000357887.3_Nonsense_Mutation_p.S52*	NM_058240.2|NM_183002.1	NP_489479.1|NP_892114.1	P57103	NAC3_HUMAN	solute carrier family 8 (sodium/calcium exchanger), member 3	52					cell communication|platelet activation	integral to membrane|plasma membrane	calcium:sodium antiporter activity|calmodulin binding			NS(1)|breast(3)|central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(12)|lung(18)|ovary(2)|pancreas(2)|prostate(3)|skin(6)	54				BRCA - Breast invasive adenocarcinoma(234;0.0079)|all cancers(60;0.0102)|OV - Ovarian serous cystadenocarcinoma(108;0.0555)		CTTGCAGTCCGATGACCCTGA	0.547000													18	38					6.94344e-10	9.02007e-10	1	1	0
AGAP1	116987	broad.mit.edu	37	2	236817478	236817478	+	Missense_Mutation	SNP	G	G	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr2:236817478G>T	ENST00000409538.1	+	11	2543	c.2047G>T	c.(2047-2049)Gca>Tca	p.A683S	AGAP1_ENST00000428334.2_Missense_Mutation_p.A257S|AGAP1_ENST00000336665.5_Missense_Mutation_p.A418S|AGAP1_ENST00000304032.7_Missense_Mutation_p.A418S			Q9UPQ3	AGAP1_HUMAN	ArfGAP with GTPase domain, ankyrin repeat and PH domain 1	418	Arf-GAP.				protein transport|regulation of ARF GTPase activity|small GTPase mediated signal transduction	cytoplasm	ARF GTPase activator activity|GTP binding|zinc ion binding			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(12)|lung(11)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	41						GTCAGCCTGCGCACCCATCTC	0.493000													12	69					9.05144e-12	1.22424e-11	1	1	0
SERGEF	26297	broad.mit.edu	37	11	18017431	18017431	+	Silent	SNP	C	C	G			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr11:18017431C>G	ENST00000265965.5	-	6	685	c.534G>C	c.(532-534)ggG>ggC	p.G178G	SERGEF_ENST00000532265.1_Silent_p.G64G|SERGEF_ENST00000528200.1_Silent_p.G178G	NM_012139.2	NP_036271.1	Q9UGK8	SRGEF_HUMAN	secretion regulating guanine nucleotide exchange factor	178					negative regulation of protein secretion|signal transduction	cytoplasm|nucleus	protein binding|Ran guanyl-nucleotide exchange factor activity			autonomic_ganglia(1)|central_nervous_system(1)|large_intestine(5)|lung(5)	12						CCAAACCAGTCCCCCACTGGA	0.493000													3	23					0	0	1	0	0
MAL	4118	broad.mit.edu	37	2	95691561	95691561	+	Silent	SNP	G	G	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr2:95691561G>A	ENST00000309988.4	+	1	133	c.24G>A	c.(22-24)ggG>ggA	p.G8G	MAL_ENST00000353004.3_Silent_p.G8G|MAL_ENST00000489399.1_3'UTR|AC103563.8_ENST00000448734.1_RNA|MAL_ENST00000354078.3_Silent_p.G8G|MAL_ENST00000349807.3_Silent_p.G8G	NM_002371.3	NP_002362.1	P21145	MAL_HUMAN	mal, T-cell differentiation protein	8					apical protein localization|cell differentiation|central nervous system development|induction of apoptosis|membrane raft polarization|myelination	apical plasma membrane|endoplasmic reticulum|endosome|integral to plasma membrane|membrane raft	apoptotic protease activator activity|channel activity|lipid binding|structural constituent of myelin sheath			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(4)|prostate(2)	10				STAD - Stomach adenocarcinoma(1183;0.18)		CGGCGACGGGGGGCAGCACCC	0.697000													6	11					0	0	1	0	0
LRRC37A11P	342666	broad.mit.edu	37	17	37186348	37186348	+	RNA	SNP	A	A	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr17:37186348A>T	ENST00000425901.2	+	0	190					NR_033753.2																						CTGCGTCCAGAGTCATCAGAA	0.522000													29	51					0	0	1	0	0
RGS22	26166	broad.mit.edu	37	8	101076197	101076197	+	Missense_Mutation	SNP	C	C	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr8:101076197C>T	ENST00000360863.6	-	8	993	c.799G>A	c.(799-801)Gaa>Aaa	p.E267K	RGS22_ENST00000523437.1_Missense_Mutation_p.E255K|RGS22_ENST00000523287.1_Missense_Mutation_p.E86K	NM_015668.3	NP_056483.3	Q8NE09	RGS22_HUMAN	regulator of G-protein signaling 22	267	Poly-Glu.				negative regulation of signal transduction	cytoplasm|plasma membrane	GTPase activator activity|signal transducer activity		RGS22/SYCP1(2)	breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(9)|lung(33)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	68			Epithelial(11;6.71e-08)|all cancers(13;4.19e-06)|OV - Ovarian serous cystadenocarcinoma(57;0.000469)|STAD - Stomach adenocarcinoma(118;0.169)			tcttcAAATTCAGAAATCAAT	0.353000													16	114					0	0	1	0	0
DENND2D	79961	broad.mit.edu	37	1	111743090	111743090	+	Translation_Start_Site	SNP	C	C	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr1:111743090C>A	ENST00000357640.4	-	0	221				DENND2D_ENST00000473682.1_5'UTR|DENND2D_ENST00000369752.5_Intron	NM_024901.3	NP_079177.2	Q9H6A0	DEN2D_HUMAN	DENN/MADD domain containing 2D											breast(1)|endometrium(1)|kidney(7)|large_intestine(4)|lung(8)|ovary(2)|prostate(1)|urinary_tract(1)	25		all_cancers(81;0.00198)|all_epithelial(167;0.000686)|all_lung(203;0.00318)|Lung NSC(277;0.00499)		Lung(183;0.0162)|Colorectal(144;0.069)|all cancers(265;0.0757)|LUSC - Lung squamous cell carcinoma(189;0.0845)|Epithelial(280;0.114)|COAD - Colon adenocarcinoma(174;0.14)		ATCTCTGGGCCTTCAGGACAG	0.577000													3	16					1	1	1	1	0
TMCC3	57458	broad.mit.edu	37	12	94975958	94975958	+	Missense_Mutation	SNP	C	C	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr12:94975958C>A	ENST00000261226.4	-	2	566	c.435G>T	c.(433-435)caG>caT	p.Q145H	TMCC3_ENST00000551457.1_Missense_Mutation_p.Q114H	NM_020698.2	NP_065749.2	Q9ULS5	TMCC3_HUMAN	transmembrane and coiled-coil domain family 3	145						integral to membrane				NS(1)|breast(3)|endometrium(2)|kidney(2)|large_intestine(8)|lung(10)|ovary(1)|skin(1)|urinary_tract(1)	29						AGGCTCCATTCTGCTCGATCT	0.478000													10	77					3.86212e-05	4.31752e-05	1	1	0
FKBP6	8468	broad.mit.edu	37	7	72742683	72742683	+	Missense_Mutation	SNP	G	G	C			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr7:72742683G>C	ENST00000252037.4	+	2	232	c.163G>C	c.(163-165)Gct>Cct	p.A55P	FKBP6_ENST00000431982.2_Missense_Mutation_p.A50P|FKBP6_ENST00000413573.2_Missense_Mutation_p.A55P	NM_003602.3	NP_003593.3	O75344	FKBP6_HUMAN	FK506 binding protein 6, 36kDa	55	PPIase FKBP-type.				protein folding	membrane	FK506 binding|peptidyl-prolyl cis-trans isomerase activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(10)	16		Lung NSC(55;0.0908)|all_lung(88;0.198)				GGCGCCTGATGCTTCGGTGCT	0.567000													15	100					0	0	1	0	0
LRP1B	53353	broad.mit.edu	37	2	141459724	141459724	+	Missense_Mutation	SNP	G	G	C			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr2:141459724G>C	ENST00000389484.3	-	39	7259	c.6288C>G	c.(6286-6288)atC>atG	p.I2096M		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	2096					protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		CAGACCAGTAGATGTAAGCCC	0.398000										TSP Lung(27;0.18)			30	85					0	0	1	0	0
PDE3A	5139	broad.mit.edu	37	12	20803534	20803534	+	Splice_Site	SNP	G	G	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr12:20803534G>A	ENST00000359062.3	+	14	2965	c.2925_splice	c.e14+1	p.Q975_splice	PDE3A_ENST00000544307.1_3'UTR	NM_000921.4|NM_001244683.1	NP_000912.3|NP_001231612.1	Q14432	PDE3A_HUMAN	phosphodiesterase 3A, cGMP-inhibited	975	Catalytic (By similarity).				lipid metabolic process|platelet activation|signal transduction	cytosol|integral to membrane	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cGMP-inhibited cyclic-nucleotide phosphodiesterase activity|metal ion binding			NS(1)|breast(3)|endometrium(4)|kidney(3)|large_intestine(7)|lung(29)|ovary(4)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	58	Esophageal squamous(101;0.125)	Breast(259;0.134)			Aminophylline(DB01223)|Amrinone(DB01427)|Anagrelide(DB00261)|Cilostazol(DB01166)|Enoximone(DB04880)|Milrinone(DB00235)|Theophylline(DB00277)	TTTATGAACAGGTAACTGACC	0.353000													10	29					0	0	1	0	0
SSTR1	6751	broad.mit.edu	37	14	38679584	38679584	+	Missense_Mutation	SNP	C	C	G			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr14:38679584C>G	ENST00000267377.2	+	3	1607	c.990C>G	c.(988-990)ttC>ttG	p.F330L		NM_001049.2	NP_001040.1	P30872	SSR1_HUMAN	somatostatin receptor 1	330					digestion|G-protein signaling, coupled to cyclic nucleotide second messenger|negative regulation of cell proliferation|response to nutrient	integral to plasma membrane	somatostatin receptor activity			breast(1)|central_nervous_system(3)|endometrium(6)|kidney(1)|large_intestine(6)|lung(8)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	29	Hepatocellular(127;0.213)|Esophageal squamous(585;0.22)		Lung(238;3.93e-06)|LUAD - Lung adenocarcinoma(48;2.62e-05)|Epithelial(34;0.187)	GBM - Glioblastoma multiforme(112;0.00444)	Octreotide(DB00104)	CAGACAACTTCAAGCGCTCTT	0.592000													111	167					0	0	1	0	0
OR3A2	4995	broad.mit.edu	37	17	3181319	3181319	+	Missense_Mutation	SNP	G	G	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr17:3181319G>A	ENST00000408891.2	-	1	949	c.911C>T	c.(910-912)cCt>cTt	p.P304L		NM_002551.3	NP_002542.3	P47893	OR3A2_HUMAN	olfactory receptor, family 3, subfamily A, member 2	304					sensory perception of smell	integral to plasma membrane	olfactory receptor activity			ovary(1)	1						CTGAACATCAGGGTTTCTGAG	0.488000													12	37					0	0	1	0	0
KLHL10	317719	broad.mit.edu	37	17	39998074	39998074	+	Splice_Site	SNP	G	G	C			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr17:39998074G>C	ENST00000293303.4	+	2	347		c.e2-1		KLHL10_ENST00000485613.1_Splice_Site	NM_152467.3	NP_689680.2	Q6JEL2	KLH10_HUMAN	kelch-like family member 10							cytoplasm				breast(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(5)|lung(7)|ovary(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	26		Breast(137;0.000162)				CTTTTTTCCAGAGCTTTGTTT	0.428000													10	85					0	0	1	0	0
NBPF10	100132406	broad.mit.edu	37	1	145368679	145368679	+	Nonsense_Mutation	SNP	C	C	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr1:145368679C>T	ENST00000342960.5	+	84	10692	c.10657C>T	c.(10657-10659)Caa>Taa	p.Q3553*	NBPF10_ENST00000369338.1_Nonsense_Mutation_p.Q669*|NBPF10_ENST00000369339.2_Nonsense_Mutation_p.Q671*	NM_001039703.4	NP_001034792.4	A6NDV3	A6NDV3_HUMAN	neuroblastoma breakpoint family, member 10	3553										NS(3)|breast(1)|central_nervous_system(3)|endometrium(12)|kidney(23)|lung(15)|ovary(1)|prostate(7)|skin(6)|urinary_tract(2)	73	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		CATATTCCCACAATAAGCAGC	0.463000													25	593					0	0	1	0	0
RPLP0P6	220717	broad.mit.edu	37	2	38709796	38709796	+	RNA	SNP	C	C	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr2:38709796C>T	ENST00000417039.1	-	0	696																											TCAAGGCCTTCTTGGCTGATC	0.552000													9	54					0	0	1	0	0
CCR5	1234	broad.mit.edu	37	3	46414769	46414769	+	Missense_Mutation	SNP	A	A	G			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr3:46414769A>G	ENST00000343801.4	+	3	733	c.376A>G	c.(376-378)Agg>Ggg	p.R126G	RP11-24F11.2_ENST00000451485.1_RNA|CCR5_ENST00000292303.4_Missense_Mutation_p.R126G|CCR5_ENST00000445772.1_Missense_Mutation_p.R126G	NM_000579.3	NP_000570.1	P51681	CCR5_HUMAN	chemokine (C-C motif) receptor 5 (gene/pseudogene)	126					cell-cell signaling|cellular defense response|dendritic cell chemotaxis|elevation of cytosolic calcium ion concentration|entry into host cell|immune response|inflammatory response|initiation of viral infection	endosome|external side of plasma membrane|integral to plasma membrane	actin binding|C-C chemokine receptor activity|coreceptor activity|phosphatidylinositol phospholipase C activity			central_nervous_system(1)|large_intestine(2)|lung(13)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	20				BRCA - Breast invasive adenocarcinoma(193;0.00112)|KIRC - Kidney renal clear cell carcinoma(197;0.017)|Kidney(197;0.02)	Maraviroc(DB04835)	GACAATCGATAGGTACCTGGC	0.478000													43	198					0	0	1	0	0
HERC2P3	283755	broad.mit.edu	37	15	20644015	20644015	+	RNA	SNP	C	C	G			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr15:20644015C>G	ENST00000428453.1	-	0	3444																				central_nervous_system(1)|endometrium(11)|kidney(2)|large_intestine(1)|lung(14)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	35						ACAGCCAGGACCGCCATGAGG	0.592000													6	71					0	0	1	0	0
SLC4A1	6521	broad.mit.edu	37	17	42333191	42333191	+	Silent	SNP	C	C	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr17:42333191C>T	ENST00000262418.6	-	14	1805	c.1650G>A	c.(1648-1650)caG>caA	p.Q550Q		NM_000342.3	NP_000333.1	P02730	B3AT_HUMAN	solute carrier family 4 (anion exchanger), member 1	550	Membrane (anion exchange).				bicarbonate transport|cellular ion homeostasis	basolateral plasma membrane|cortical cytoskeleton|integral to plasma membrane|Z disc	ankyrin binding|chloride transmembrane transporter activity|inorganic anion exchanger activity|protein anchor|protein homodimerization activity			central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(9)|lung(16)|ovary(2)|prostate(3)|skin(1)|urinary_tract(1)	40		Breast(137;0.014)|Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.115)		TATAAGTCTTCTGTAGTGGGT	0.532000													10	97					0	0	1	0	0
TMTC2	160335	broad.mit.edu	37	12	83251126	83251126	+	Missense_Mutation	SNP	G	G	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr12:83251126G>A	ENST00000549919.1	+	3	2208	c.403G>A	c.(403-405)Gat>Aat	p.D135N	TMTC2_ENST00000548305.1_Missense_Mutation_p.D141N|TMTC2_ENST00000321196.3_Missense_Mutation_p.D141N			Q8N394	TMTC2_HUMAN	transmembrane and tetratricopeptide repeat containing 2	141						endoplasmic reticulum|integral to membrane	binding			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(7)|lung(13)|ovary(2)|skin(1)|urinary_tract(1)	39						GGGACGAGCCGATGTCGGGGC	0.542000													11	38					0	0	1	0	0
RPS3A	6189	broad.mit.edu	37	4	152025386	152025386	+	Missense_Mutation	SNP	C	C	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr4:152025386C>T	ENST00000512690.1	+	5	627	c.613C>T	c.(613-615)Cca>Tca	p.P205S	RPS3A_ENST00000274065.4_Silent_p.L207L|RPS3A_ENST00000514682.1_Silent_p.L170L|RPS3A_ENST00000509736.1_Silent_p.L88L|RPS3A_ENST00000506126.1_Silent_p.L170L			P61247	RS3A_HUMAN	ribosomal protein S3A	0					cell differentiation|endocrine pancreas development|induction of apoptosis|translational elongation|translational initiation|translational termination|viral transcription	cytosolic small ribosomal subunit|nucleolus	protein binding|RNA binding|structural constituent of ribosome			endometrium(1)|lung(1)|ovary(1)|pancreas(1)	4	all_hematologic(180;0.093)					TTTATCCTCTCCATGATGTCT	0.353000													5	37					0	0	1	0	0
ADARB1	104	broad.mit.edu	37	21	46600262	46600262	+	Silent	SNP	C	C	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr21:46600262C>T	ENST00000539173.1	+	5	1416	c.981C>T	c.(979-981)gtC>gtT	p.V327V	ADARB1_ENST00000389863.4_Silent_p.V327V|ADARB1_ENST00000348831.4_Silent_p.V327V|ADARB1_ENST00000437626.1_3'UTR|ADARB1_ENST00000360697.3_Silent_p.V327V	NM_015833.3	NP_056648.1	P78563	RED1_HUMAN	adenosine deaminase, RNA-specific, B1	327					adenosine to inosine editing|mRNA modification|mRNA processing|RNA processing	nucleoplasm|nucleus	double-stranded RNA adenosine deaminase activity|double-stranded RNA binding|metal ion binding|mRNA binding|RNA binding			endometrium(4)|kidney(1)|large_intestine(3)|lung(8)|skin(1)	17				Colorectal(79;0.115)		CTGACGCTGTCTCACGCCTGG	0.572000													6	24					0	0	1	0	0
CHID1	66005	broad.mit.edu	37	11	902221	902221	+	Missense_Mutation	SNP	G	G	A	rs139154177		TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr11:902221G>A	ENST00000449825.1	-	4	727	c.371C>T	c.(370-372)aCg>aTg	p.T124M	CHID1_ENST00000526714.1_5'UTR|CHID1_ENST00000336845.5_Missense_Mutation_p.T149M|CHID1_ENST00000528581.1_Missense_Mutation_p.T149M|CHID1_ENST00000323541.7_Missense_Mutation_p.T154M|CHID1_ENST00000454838.2_Missense_Mutation_p.T149M|CHID1_ENST00000436108.2_Missense_Mutation_p.T124M|CHID1_ENST00000429789.2_Missense_Mutation_p.T124M|CHID1_ENST00000323578.8_Missense_Mutation_p.T124M	NM_001142675.1	NP_001136147.1	Q9BWS9	CHID1_HUMAN	chitinase domain containing 1	124					chitin catabolic process|innate immune response	extracellular region|lysosome	cation binding|chitinase activity	p.T124M(1)		endometrium(4)|kidney(1)|large_intestine(1)|lung(4)|ovary(1)|prostate(1)|skin(1)	13		all_cancers(49;9.46e-06)|Breast(177;0.00257)|all_epithelial(84;0.0027)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;5.48e-25)|Epithelial(43;3.75e-24)|BRCA - Breast invasive adenocarcinoma(625;4.65e-05)|Lung(200;0.0624)|LUSC - Lung squamous cell carcinoma(625;0.0735)		GTGGAGGCCCGTGACCTCAAA	0.567000													11	50					0	0	1	0	0
ATP6AP2	10159	broad.mit.edu	37	X	40456778	40456778	+	Splice_Site	SNP	G	G	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chrX:40456778G>A	ENST00000378438.4	+	5	554		c.e5-1		ATP6AP2_ENST00000535777.1_Intron|ATP6AP2_ENST00000486558.1_Splice_Site|ATP6AP2_ENST00000544975.1_Splice_Site|ATP6AP2_ENST00000535539.1_Splice_Site	NM_005765.2	NP_005756.2	O75787	RENR_HUMAN	ATPase, H+ transporting, lysosomal accessory protein 2						angiotensin maturation|positive regulation of transforming growth factor-beta1 production|regulation of MAPKKK cascade	external side of plasma membrane|integral to membrane	protein binding|receptor activity			endometrium(1)|large_intestine(1)|lung(2)	4						TCTTCTTACAGAGAGTGTATA	0.368000													15	59					0	0	1	0	0
RSPO4	343637	broad.mit.edu	37	20	944677	944677	+	Missense_Mutation	SNP	G	G	C			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr20:944677G>C	ENST00000217260.4	-	4	592	c.496C>G	c.(496-498)Cgg>Ggg	p.R166G	RSPO4_ENST00000400634.2_Intron	NM_001029871.3	NP_001025042.2	Q2I0M5	RSPO4_HUMAN	R-spondin 4	166	TSP type-1.				Wnt receptor signaling pathway	extracellular region	heparin binding			endometrium(1)|kidney(1)|large_intestine(2)|lung(3)	7						TCTCGTACCCGGCTCTCCAGG	0.657000													11	44					0	0	1	0	0
COL4A4	1286	broad.mit.edu	37	2	227985809	227985809	+	Missense_Mutation	SNP	C	C	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr2:227985809C>A	ENST00000396625.3	-	5	455	c.248G>T	c.(247-249)gGa>gTa	p.G83V	COL4A4_ENST00000329662.7_Missense_Mutation_p.G83V	NM_000092.4	NP_000083.3	P53420	CO4A4_HUMAN	collagen, type IV, alpha 4	83	Triple-helical region.				axon guidance|glomerular basement membrane development	basal lamina|collagen type IV	extracellular matrix structural constituent|protein binding			breast(2)|central_nervous_system(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(15)|lung(35)|ovary(5)|pancreas(3)|prostate(2)|skin(12)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	98		Renal(207;0.00844)|all_lung(227;0.0187)|Lung NSC(271;0.0879)|all_hematologic(139;0.21)|Esophageal squamous(248;0.242)		Epithelial(121;6.7e-11)|all cancers(144;5.39e-08)|Lung(261;0.0132)|LUSC - Lung squamous cell carcinoma(224;0.0181)		CCCAATGGGTCCTGGGGCTCC	0.542000													19	55					5.35267e-07	6.4206e-07	1	1	0
FAM155A	728215	broad.mit.edu	37	13	108518593	108518593	+	Missense_Mutation	SNP	G	G	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr13:108518593G>T	ENST00000375915.2	-	1	490	c.352C>A	c.(352-354)Cag>Aag	p.Q118K		NM_001080396.2	NP_001073865.1	B1AL88	F155A_HUMAN	family with sequence similarity 155, member A	118						integral to membrane	binding			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(11)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	33						CTGTGTGCCTGGGCGGCGGGC	0.756000													5	16					0.014758	0.0152052	1	1	0
DMBT1	1755	broad.mit.edu	37	10	124351968	124351968	+	Missense_Mutation	SNP	C	C	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr10:124351968C>A	ENST00000368909.3	+	20	2463	c.2357C>A	c.(2356-2358)gCc>gAc	p.A786D	DMBT1_ENST00000359586.6_Intron|DMBT1_ENST00000330163.4_Intron|DMBT1_ENST00000368956.2_Intron|DMBT1_ENST00000368955.3_Missense_Mutation_p.A776D|DMBT1_ENST00000344338.3_Missense_Mutation_p.A776D|DMBT1_ENST00000338354.3_Missense_Mutation_p.A786D	NM_007329.2	NP_015568.2	Q9UGM3	DMBT1_HUMAN	deleted in malignant brain tumors 1	786	SRCR 6.				epithelial cell differentiation|induction of bacterial agglutination|innate immune response|interspecies interaction between organisms|protein transport|response to virus	extrinsic to membrane|phagocytic vesicle membrane|zymogen granule membrane	calcium-dependent protein binding|Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|pattern recognition receptor activity|scavenger receptor activity|zymogen binding			breast(2)|central_nervous_system(7)|cervix(3)|endometrium(8)|kidney(1)|large_intestine(1)|lung(46)|prostate(1)|urinary_tract(3)	72		all_neural(114;0.0765)|Lung NSC(174;0.132)|all_lung(145;0.163)|Breast(234;0.238)				CCAGGAAATGCCCGGTTTGGC	0.622000													57	266					9.72345e-25	1.45926e-24	1	1	0
GSE1	23199	broad.mit.edu	37	16	85701835	85701835	+	Missense_Mutation	SNP	G	G	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr16:85701835G>T	ENST00000253458.7	+	14	3396	c.3220G>T	c.(3220-3222)Gcc>Tcc	p.A1074S	GSE1_ENST00000405402.2_Missense_Mutation_p.A970S|GSE1_ENST00000393243.1_Missense_Mutation_p.A1001S	NM_014615.2	NP_055430.1			Gse1 coiled-coil protein																		CTCCAGCCGCGCCCCTCCACC	0.647000													20	101					4.47668e-21	6.67777e-21	1	1	0
KLHL35	283212	broad.mit.edu	37	11	75139628	75139628	+	Missense_Mutation	SNP	C	C	G			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr11:75139628C>G	ENST00000539798.1	-	2	924	c.925G>C	c.(925-927)Gac>Cac	p.D309H	KLHL35_ENST00000376292.4_Missense_Mutation_p.D89H	NM_001039548.2	NP_001034637.2	Q6PF15	KLH35_HUMAN	kelch-like family member 35	89										lung(2)|stomach(1)	3						CCTTTGCGGTCGCAACCGCCG	0.627000													6	40					0	0	1	0	0
NQO2	4835	broad.mit.edu	37	6	3012804	3012804	+	Missense_Mutation	SNP	A	A	G			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr6:3012804A>G	ENST00000338130.2	+	7	911	c.199A>G	c.(199-201)Aat>Gat	p.N67D	NQO2_ENST00000380430.1_Missense_Mutation_p.N67D|NQO2_ENST00000380455.4_Missense_Mutation_p.N67D|NQO2_ENST00000380441.1_Missense_Mutation_p.N67D|NQO2_ENST00000380454.4_Missense_Mutation_p.N67D			P16083	NQO2_HUMAN	NAD(P)H dehydrogenase, quinone 2	67						cytoplasm|nucleus	coenzyme binding|dihydronicotinamide riboside quinone reductase activity|electron carrier activity|metal ion binding|NADPH dehydrogenase (quinone) activity			endometrium(1)|large_intestine(1)|lung(2)|ovary(1)|prostate(1)|skin(1)	7	Ovarian(93;0.0412)	all_hematologic(90;0.0895)			Menadione(DB00170)|NADH(DB00157)	TGAGGTTTTCAATTATGGAGT	0.502000													27	44					0	0	1	0	0
ZNF804A	91752	broad.mit.edu	37	2	185802027	185802027	+	Missense_Mutation	SNP	T	T	C			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr2:185802027T>C	ENST00000302277.6	+	4	2498	c.1904T>C	c.(1903-1905)tTg>tCg	p.L635S		NM_194250.1	NP_919226.1	Q7Z570	Z804A_HUMAN	zinc finger protein 804A	635						intracellular	zinc ion binding			NS(5)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(22)|liver(2)|lung(79)|ovary(7)|pancreas(1)|prostate(2)|skin(12)|urinary_tract(1)	146						AAATATCTATTGGAACCAATT	0.358000													13	92					0	0	1	0	0
PNMAL2	57469	broad.mit.edu	37	19	46997684	46997684	+	Missense_Mutation	SNP	G	G	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr19:46997684G>A	ENST00000599531.1	-	1	2071	c.1039C>T	c.(1039-1041)Cgg>Tgg	p.R347W	PNMAL2_ENST00000377655.2_Intron|PNMAL2_ENST00000594749.1_Intron	NM_020709.1	NP_065760.1	Q9ULN7	PNML2_HUMAN	paraneoplastic Ma antigen family-like 2	347										central_nervous_system(1)|endometrium(2)|large_intestine(1)|lung(4)	8		Ovarian(192;0.00965)|all_neural(266;0.0459)		OV - Ovarian serous cystadenocarcinoma(262;0.000322)|all cancers(93;0.00233)|GBM - Glioblastoma multiforme(486;0.0421)|Epithelial(262;0.0427)		ATCTCCTCCCGGGCCCAGGGG	0.577000													26	179					0	0	1	0	0
INVS	27130	broad.mit.edu	37	9	102888741	102888741	+	Missense_Mutation	SNP	G	G	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr9:102888741G>T	ENST00000262457.2	+	3	368	c.183G>T	c.(181-183)ttG>ttT	p.L61F	INVS_ENST00000460636.2_3'UTR|INVS_ENST00000374921.3_Missense_Mutation_p.L61F|INVS_ENST00000262456.2_Missense_Mutation_p.L61F|INVS_ENST00000541287.1_5'UTR	NM_014425.3	NP_055240.2	Q9Y283	INVS_HUMAN	inversin	61					negative regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	cytoplasm|membrane|microtubule|nucleus|spindle	calmodulin binding			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(5)|ovary(4)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	31		Acute lymphoblastic leukemia(62;0.056)				CTGACAGATTGGATTGTGCAG	0.438000													20	26					1.01871e-10	1.34826e-10	1	1	0
SLC2A10	81031	broad.mit.edu	37	20	45353921	45353921	+	Missense_Mutation	SNP	C	C	G			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr20:45353921C>G	ENST00000359271.2	+	2	496	c.246C>G	c.(244-246)aaC>aaG	p.N82K		NM_030777.3	NP_110404.1	O95528	GTR10_HUMAN	solute carrier family 2 (facilitated glucose transporter), member 10	82						endomembrane system|integral to membrane|perinuclear region of cytoplasm|plasma membrane	D-glucose transmembrane transporter activity|sugar:hydrogen symporter activity			central_nervous_system(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(9)|liver(2)|lung(13)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)	34		Myeloproliferative disorder(115;0.0122)				TCGGGAGCAACTTGGTGCTGC	0.657000													12	40					0	0	1	0	0
ARHGEF40	55701	broad.mit.edu	37	14	21546374	21546374	+	Silent	SNP	G	G	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr14:21546374G>T	ENST00000298694.4	+	9	2200	c.2073G>T	c.(2071-2073)ctG>ctT	p.L691L	ARHGEF40_ENST00000298693.3_Silent_p.L691L			Q8TER5	ARH40_HUMAN	Rho guanine nucleotide exchange factor (GEF) 40	691					regulation of Rho protein signal transduction	cytoplasm	Rho guanyl-nucleotide exchange factor activity			large_intestine(4)|ovary(3)|upper_aerodigestive_tract(2)	9						AAGGTGTGCTGGGCTCGGTAC	0.552000													17	33					2.94398e-08	3.71198e-08	1	1	0
C3orf20	84077	broad.mit.edu	37	3	14813695	14813695	+	Silent	SNP	C	C	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr3:14813695C>T	ENST00000253697.3	+	16	3069	c.2617C>T	c.(2617-2619)Ctg>Ttg	p.L873L	C3orf20_ENST00000435614.1_Silent_p.L751L|C3orf20_ENST00000412910.1_Silent_p.L751L	NM_032137.4	NP_115513.4	Q8ND61	CC020_HUMAN	chromosome 3 open reading frame 20	873						cytoplasm|integral to membrane				NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(13)|lung(11)|ovary(4)|skin(2)	40						GGAGTTATCTCTGGAGGCTGA	0.547000													13	34					0	0	1	0	0
HECW1	23072	broad.mit.edu	37	7	43484586	43484586	+	Silent	SNP	G	G	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr7:43484586G>A	ENST00000395891.1	+	11	2420	c.1815G>A	c.(1813-1815)acG>acA	p.T605T	HECW1_ENST00000453890.1_Silent_p.T605T	NM_015052.3	NP_055867.3	Q76N89	HECW1_HUMAN	HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1	605					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	ubiquitin-protein ligase activity			NS(2)|breast(10)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(17)|lung(57)|ovary(8)|pancreas(2)|prostate(2)|skin(6)|urinary_tract(3)	125						AGGTGGACACGGTGGCCGCTG	0.711000													6	42					0	0	1	0	0
ENTHD1	150350	broad.mit.edu	37	22	40139715	40139715	+	Missense_Mutation	SNP	T	T	G			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr22:40139715T>G	ENST00000325157.6	-	7	2043	c.1793A>C	c.(1792-1794)cAg>cCg	p.Q598P		NM_152512.3	NP_689725.2	Q8IYW4	ENTD1_HUMAN	ENTH domain containing 1	598										breast(2)|endometrium(1)|kidney(6)|large_intestine(6)|lung(11)|ovary(3)|skin(3)	32	Melanoma(58;0.0749)					CTCAGAAGACTGGGGGACCTG	0.418000													13	57					0	0	1	0	0
OR10K1	391109	broad.mit.edu	37	1	158435684	158435684	+	Silent	SNP	C	C	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr1:158435684C>T	ENST00000289451.2	+	1	413	c.333C>T	c.(331-333)caC>caT	p.H111H		NM_001004473.1	NP_001004473.1	Q8NGX5	O10K1_HUMAN	olfactory receptor, family 10, subfamily K, member 1	111					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(1)|lung(15)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|stomach(1)	27	all_hematologic(112;0.0378)					GCTCCTCTCACTCCTTCCTGC	0.517000													125	149					0	0	1	0	0
PDK4	5166	broad.mit.edu	37	7	95216342	95216342	+	Missense_Mutation	SNP	C	C	G			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr7:95216342C>G	ENST00000005178.5	-	10	1272	c.1075G>C	c.(1075-1077)Gat>Cat	p.D359H		NM_002612.3	NP_002603.1	Q16654	PDK4_HUMAN	pyruvate dehydrogenase kinase, isozyme 4	359	Histidine kinase.				glucose metabolic process|peptidyl-histidine phosphorylation|pyruvate metabolic process|regulation of acetyl-CoA biosynthetic process from pyruvate	mitochondrial matrix	ATP binding|pyruvate dehydrogenase (acetyl-transferring) kinase activity|two-component sensor activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|liver(1)|lung(4)|skin(1)|upper_aerodigestive_tract(1)	15	all_cancers(62;1.06e-10)|all_epithelial(64;1.04e-09)|Lung NSC(181;0.128)|all_lung(186;0.151)		STAD - Stomach adenocarcinoma(171;0.0151)			ATGATAGCATCTGTTCCATAT	0.393000													4	36					0	0	1	0	0
EGFLAM	133584	broad.mit.edu	37	5	38338847	38338847	+	Missense_Mutation	SNP	G	G	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr5:38338847G>T	ENST00000322350.5	+	3	601	c.255G>T	c.(253-255)ttG>ttT	p.L85F	EGFLAM_ENST00000354891.3_Missense_Mutation_p.L85F	NM_152403.3	NP_689616.2	Q63HQ2	EGFLA_HUMAN	EGF-like, fibronectin type III and laminin G domains	85	Fibronectin type-III 1.					cell junction|proteinaceous extracellular matrix|synapse				NS(1)|breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(43)|ovary(1)|pancreas(3)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	85	all_lung(31;0.000385)					AGGAGCAGTTGCACAGCGTGC	0.552000													35	51					1.04352e-10	1.37923e-10	1	1	0
RAB11FIP1	80223	broad.mit.edu	37	8	37734903	37734903	+	Nonsense_Mutation	SNP	T	T	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr8:37734903T>A	ENST00000330843.4	-	2	550	c.538A>T	c.(538-540)Aag>Tag	p.K180*	RAB11FIP1_ENST00000287263.4_Nonsense_Mutation_p.K180*|RAB11FIP1_ENST00000522727.1_Nonsense_Mutation_p.K32*|RAB11FIP1_ENST00000524118.1_Nonsense_Mutation_p.K32*	NM_001002814.2	NP_001002814.2	Q6WKZ4	RFIP1_HUMAN	RAB11 family interacting protein 1 (class I)	180					protein transport	centrosome|phagocytic vesicle membrane|recycling endosome	protein binding			NS(1)|breast(1)|central_nervous_system(4)|endometrium(3)|large_intestine(6)|lung(20)|ovary(3)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	49		Lung NSC(58;0.118)|all_lung(54;0.195)	LUSC - Lung squamous cell carcinoma(8;3.62e-11)			TCCTTATTCTTCCCCTTGATC	0.463000													68	141					0	0	1	0	0
C2orf78	388960	broad.mit.edu	37	2	74043571	74043571	+	Missense_Mutation	SNP	C	C	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr2:74043571C>A	ENST00000409561.1	+	3	2342	c.2221C>A	c.(2221-2223)Cta>Ata	p.L741I		NM_001080474.1	NP_001073943.1	A6NCI8	CB078_HUMAN	chromosome 2 open reading frame 78	741										cervix(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(21)|ovary(2)|prostate(2)|soft_tissue(1)|urinary_tract(1)	34						GCCAAACCCTCTAGCCTCACG	0.542000													73	155					7.33394e-39	1.13165e-38	1	1	0
CACNA1E	777	broad.mit.edu	37	1	181725202	181725202	+	Missense_Mutation	SNP	C	C	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr1:181725202C>A	ENST00000526775.1	+	28	4208	c.4043C>A	c.(4042-4044)aCc>aAc	p.T1348N	CACNA1E_ENST00000357570.5_Missense_Mutation_p.T1318N|CACNA1E_ENST00000358338.5_Missense_Mutation_p.T1299N|CACNA1E_ENST00000367570.1_Missense_Mutation_p.T1367N|CACNA1E_ENST00000360108.3_Missense_Mutation_p.T1348N|CACNA1E_ENST00000367573.2_Missense_Mutation_p.T1367N|CACNA1E_ENST00000367567.4_Missense_Mutation_p.T974N	NM_001205294.1	NP_001192223.1	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type, alpha 1E subunit	1367					energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			NS(2)|breast(9)|central_nervous_system(3)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(6)|kidney(4)|large_intestine(34)|lung(99)|ovary(6)|pancreas(1)|prostate(9)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	204						ACCCTCTTCACCGTCTCCACA	0.522000													7	31					0.000157383	0.000172422	1	1	0
CHRNA4	1137	broad.mit.edu	37	20	61981345	61981345	+	Missense_Mutation	SNP	C	C	G			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr20:61981345C>G	ENST00000370263.4	-	5	1639	c.1418G>C	c.(1417-1419)aGc>aCc	p.S473T	CHRNA4_ENST00000463705.1_5'UTR	NM_000744.6|NM_001256573.1	NP_000735.1|NP_001243502.1	P43681	ACHA4_HUMAN	cholinergic receptor, nicotinic, alpha 4 (neuronal)	473					B cell activation|behavioral response to nicotine|calcium ion transport|cognition|DNA repair|membrane depolarization|regulation of action potential|regulation of dopamine secretion|regulation of inhibitory postsynaptic membrane potential|response to hypoxia|response to oxidative stress|sensory perception of pain|synaptic transmission, cholinergic	cell junction|dendrite|external side of plasma membrane|membrane fraction|neuronal cell body|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity			breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(19)|prostate(3)|skin(3)|soft_tissue(1)	33	all_cancers(38;1.71e-10)				Nicotine(DB00184)|Varenicline(DB01273)	TTCGCCAGGGCTGGACATGTG	0.721000													3	6					0	0	1	0	0
CCNT1	904	broad.mit.edu	37	12	49099550	49099550	+	Splice_Site	SNP	C	C	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr12:49099550C>A	ENST00000261900.3	-	3	595		c.e3+1			NM_001240.3	NP_001231.2	O60563	CCNT1_HUMAN	cyclin T1						cell cycle|cell division|interspecies interaction between organisms|positive regulation of viral transcription|protein phosphorylation|regulation of cyclin-dependent protein kinase activity|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|viral reproduction	nucleoplasm	DNA binding|protein kinase binding			breast(3)|endometrium(1)|kidney(1)|large_intestine(4)|lung(13)|ovary(3)|skin(2)	27						TAATCTCCTACCTCACTTCTA	0.383000													11	31					0.000673444	0.0007257	1	1	0
ZNF513	130557	broad.mit.edu	37	2	27603092	27603092	+	Missense_Mutation	SNP	C	C	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr2:27603092C>T	ENST00000323703.6	-	2	277	c.79G>A	c.(79-81)Gaa>Aaa	p.E27K	ZNF513_ENST00000407879.1_5'UTR	NM_144631.5	NP_653232.3	Q8N8E2	ZN513_HUMAN	zinc finger protein 513	27					regulation of transcription, DNA-dependent|response to stimulus|retina development in camera-type eye|transcription, DNA-dependent|visual perception	nucleus	transcription regulatory region DNA binding|zinc ion binding			endometrium(5)|kidney(1)|large_intestine(2)|lung(7)|ovary(2)	17	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CCGGGTCCTTCGTCGAGGGAG	0.582000													11	112					0	0	1	0	0
FOXG1	2290	broad.mit.edu	37	14	29237818	29237818	+	Missense_Mutation	SNP	C	C	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr14:29237818C>A	ENST00000382535.3	+	2	1702	c.1333C>A	c.(1333-1335)Ccg>Acg	p.P445T	FOXG1_ENST00000313071.4_Missense_Mutation_p.P445T			P55316	FOXG1_HUMAN	forkhead box G1	445					axon midline choice point recognition|central nervous system neuron development|dorsal/ventral pattern formation|embryo development ending in birth or egg hatching|hindbrain development|inner ear morphogenesis|negative regulation of neuron differentiation|negative regulation of transcription, DNA-dependent|nonmotile primary cilium assembly|nose development|positive regulation of cell cycle|positive regulation of neuroblast proliferation|positive regulation of transcription from RNA polymerase II promoter|regulation of mitotic cell cycle|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding	p.P445S(1)		breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(9)|lung(23)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|urinary_tract(2)	43			LUAD - Lung adenocarcinoma(48;0.011)|Lung(238;0.0575)	GBM - Glioblastoma multiforme(265;0.00413)		CTCCACGTCGCCGCAGGCCCC	0.597000													25	129					9.04412e-07	1.0731e-06	1	1	0
SHANK1	50944	broad.mit.edu	37	19	51205827	51205827	+	Silent	SNP	C	C	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr19:51205827C>T	ENST00000293441.1	-	11	1662	c.1644G>A	c.(1642-1644)agG>agA	p.R548R	SHANK1_ENST00000391814.1_Silent_p.R548R|SHANK1_ENST00000359082.3_Silent_p.R548R	NM_016148.2	NP_057232.2	Q9Y566	SHAN1_HUMAN	SH3 and multiple ankyrin repeat domains 1	548					cytoskeletal anchoring at plasma membrane	cell junction|cytoplasm|dendrite|membrane fraction|postsynaptic density|postsynaptic membrane	ionotropic glutamate receptor binding			breast(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(15)|liver(1)|lung(21)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)	64		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00493)|GBM - Glioblastoma multiforme(134;0.0199)		AGTAGAGCTTCCTCCGCCTCC	0.706000													4	21					0	0	1	0	0
USH2A	7399	broad.mit.edu	37	1	216052257	216052257	+	Missense_Mutation	SNP	G	G	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr1:216052257G>T	ENST00000366943.2	-	42	8793	c.8407C>A	c.(8407-8409)Ctt>Att	p.L2803I	USH2A_ENST00000307340.3_Missense_Mutation_p.L2803I			O75445	USH2A_HUMAN	Usher syndrome 2A (autosomal recessive, mild)	2803	Fibronectin type-III 14.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			NS(7)|breast(20)|central_nervous_system(3)|cervix(2)|endometrium(32)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(71)|liver(2)|lung(282)|ovary(25)|pancreas(2)|prostate(12)|skin(22)|stomach(7)|upper_aerodigestive_tract(20)|urinary_tract(3)	527				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		CACCCTCCAAGGTACCCATTA	0.443000										HNSCC(13;0.011)			21	148					6.44725e-10	8.39761e-10	1	1	0
ANTXR2	118429	broad.mit.edu	37	4	80828601	80828601	+	Silent	SNP	G	G	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr4:80828601G>A	ENST00000403729.2	-	17	1974	c.1449C>T	c.(1447-1449)tcC>tcT	p.S483S	ANTXR2_ENST00000482406.1_5'UTR|ANTXR2_ENST00000404191.1_Silent_p.S406S	NM_058172.5	NP_477520.2	P58335	ANTR2_HUMAN	anthrax toxin receptor 2	0						endoplasmic reticulum membrane|extracellular region|integral to membrane|plasma membrane	metal ion binding|protein binding|receptor activity			endometrium(2)|kidney(1)|large_intestine(2)|lung(7)|ovary(1)	13						ATGGAACTCGGGAGAAGTTTA	0.363000									Juvenile Hyaline Fibromatosis				12	64					0	0	1	0	0
ABCA6	23460	broad.mit.edu	37	17	67098996	67098996	+	Missense_Mutation	SNP	T	T	C			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr17:67098996T>C	ENST00000284425.2	-	21	3028	c.2854A>G	c.(2854-2856)Ata>Gta	p.I952V		NM_080284.2	NP_525023.2	Q8N139	ABCA6_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 6	952					transport	integral to membrane	ATP binding|ATPase activity			breast(6)|endometrium(5)|kidney(17)|large_intestine(18)|lung(20)|ovary(3)|prostate(2)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	82	Breast(10;5.65e-12)					CCAGAAACTATGATAGCTCCA	0.299000													5	25					0	0	1	0	0
C1orf173	127254	broad.mit.edu	37	1	75037739	75037739	+	Missense_Mutation	SNP	G	G	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr1:75037739G>T	ENST00000326665.5	-	14	3873	c.3655C>A	c.(3655-3657)Cct>Act	p.P1219T	C1orf173_ENST00000433746.2_5'UTR	NM_001002912.4	NP_001002912.4	Q5RHP9	CA173_HUMAN	chromosome 1 open reading frame 173	1219	Glu-rich.									NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(23)|lung(123)|ovary(3)|prostate(10)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)	184						TCAGCTTCAGGAGCTGCTAAG	0.612000													100	133					3.06722e-38	4.72543e-38	1	1	0
FARSA	2193	broad.mit.edu	37	19	13035059	13035059	+	Missense_Mutation	SNP	C	C	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr19:13035059C>A	ENST00000588025.1	-	13	1554	c.1414G>T	c.(1414-1416)Gtc>Ttc	p.V472F	FARSA_ENST00000314606.4_Missense_Mutation_p.V432F|FARSA_ENST00000423140.2_Missense_Mutation_p.V401F			Q9Y285	SYFA_HUMAN	phenylalanyl-tRNA synthetase, alpha subunit	432					phenylalanyl-tRNA aminoacylation	cytosol|soluble fraction	ATP binding|phenylalanine-tRNA ligase activity|protein binding|tRNA binding			NS(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(9)|ovary(3)|upper_aerodigestive_tract(1)	20					L-Phenylalanine(DB00120)	GAGTTTCCGACCTCCACCCAC	0.607000													19	154					1.50039e-11	2.02378e-11	1	1	0
METTL23	124512	broad.mit.edu	37	17	74729741	74729741	+	Silent	SNP	C	C	G	rs143884158	by1000genomes	TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr17:74729741C>G	ENST00000341249.6	+	5	878	c.546C>G	c.(544-546)gtC>gtG	p.V182V	METTL23_ENST00000588822.1_Silent_p.V115V|METTL23_ENST00000588783.1_3'UTR|METTL23_ENST00000590964.1_Silent_p.V115V|METTL23_ENST00000586200.1_Silent_p.V63V|METTL23_ENST00000586738.1_3'UTR|RP11-318A15.7_ENST00000587459.1_Intron|METTL23_ENST00000586752.1_Silent_p.V115V|METTL23_ENST00000588302.1_3'UTR	NM_001206984.1	NP_001193913.1	Q86XA0	MET23_HUMAN	methyltransferase like 23	182						integral to membrane	methyltransferase activity			large_intestine(2)|lung(1)	3						AAATGCTGGTCATTTCCTTTG	0.413000													8	77					0	0	1	0	0
PRSS3P2	154754	broad.mit.edu	37	7	142481807	142481807	+	RNA	SNP	C	C	T	rs4726591	by1000genomes	TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr7:142481807C>T	ENST00000603901.1	+	0	486					NR_001296.3																						AGTGCCTGGACGCTCCTGTGC	0.502000													7	35					0	0	1	0	0
BRD8	10902	broad.mit.edu	37	5	137488308	137488308	+	Missense_Mutation	SNP	G	G	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr5:137488308G>A	ENST00000254900.5	-	21	3090	c.2719C>T	c.(2719-2721)Cca>Tca	p.P907S		NM_139199.1	NP_631938.1	Q9H0E9	BRD8_HUMAN	bromodomain containing 8	907					cell surface receptor linked signaling pathway|histone H2A acetylation|histone H4 acetylation|regulation of growth|regulation of transcription from RNA polymerase II promoter	mitochondrion|NuA4 histone acetyltransferase complex	sequence-specific DNA binding transcription factor activity|thyroid hormone receptor activity			breast(2)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(9)|ovary(1)|prostate(1)|skin(1)|stomach(3)|urinary_tract(1)	35			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0109)			TCAGCCTCTGGATCCTCAGTT	0.537000													43	222					0	0	1	0	0
OSBPL1A	114876	broad.mit.edu	37	18	21897298	21897298	+	Missense_Mutation	SNP	T	T	C			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr18:21897298T>C	ENST00000319481.3	-	10	1005	c.799A>G	c.(799-801)Agg>Ggg	p.R267G		NM_080597.3	NP_542164.2	Q9BXW6	OSBL1_HUMAN	oxysterol binding protein-like 1A	267	PH.				cholesterol metabolic process|lipid transport|vesicle-mediated transport		phospholipid binding			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(16)|ovary(4)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	36	all_cancers(21;0.000396)|all_epithelial(16;4.36e-06)|Lung NSC(20;0.00171)|all_lung(20;0.0055)|Colorectal(14;0.0505)|Ovarian(20;0.17)					TACTGTTTCCTATACCATGAA	0.318000													6	78					0	0	1	0	0
ZEB1	6935	broad.mit.edu	37	10	31809297	31809297	+	Missense_Mutation	SNP	A	A	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr10:31809297A>T	ENST00000446923.2	+	7	1377	c.986A>T	c.(985-987)cAa>cTa	p.Q329L	ZEB1_ENST00000559858.1_3'UTR|ZEB1_ENST00000320985.10_Missense_Mutation_p.Q345L|ZEB1_ENST00000560721.2_Missense_Mutation_p.Q325L|ZEB1_ENST00000542815.3_Missense_Mutation_p.Q278L|ZEB1_ENST00000361642.5_Missense_Mutation_p.Q346L	NM_001128128.2|NM_001174094.1	NP_001121600.1|NP_001167565.1	P37275	ZEB1_HUMAN	zinc finger E-box binding homeobox 1	345					cell proliferation|immune response|negative regulation of transcription from RNA polymerase II promoter|positive regulation of neuron differentiation	cytoplasm	E-box binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity|zinc ion binding			NS(2)|breast(4)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(14)|lung(38)|ovary(3)|skin(6)|upper_aerodigestive_tract(4)	77		Prostate(175;0.0156)				TCTGTTAACCAAATTAAAACT	0.423000													12	41					0	0	1	0	0
VAT1L	57687	broad.mit.edu	37	16	77850871	77850871	+	Missense_Mutation	SNP	C	C	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr16:77850871C>A	ENST00000302536.2	+	2	440	c.287C>A	c.(286-288)cCc>cAc	p.P96H		NM_020927.1	NP_065978.1	Q9HCJ6	VAT1L_HUMAN	vesicle amine transport 1-like	96							oxidoreductase activity|zinc ion binding	p.P96L(1)		central_nervous_system(1)|endometrium(3)|large_intestine(5)|lung(10)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	24						GACAACCCTCCCAAGACTCCC	0.438000													18	116					5.3912e-06	6.2538e-06	1	1	0
NPY5R	4889	broad.mit.edu	37	4	164271727	164271727	+	Missense_Mutation	SNP	C	C	A	rs79962221		TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr4:164271727C>A	ENST00000515560.1	+	4	1824	c.302C>A	c.(301-303)tCt>tAt	p.S101Y	NPY5R_ENST00000506953.1_Missense_Mutation_p.S101Y|NPY5R_ENST00000338566.3_Missense_Mutation_p.S101Y			Q15761	NPY5R_HUMAN	neuropeptide Y receptor Y5	101					cardiac left ventricle morphogenesis|outflow tract morphogenesis	integral to plasma membrane				NS(2)|biliary_tract(1)|breast(1)|endometrium(3)|large_intestine(4)|lung(26)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	42	all_hematologic(180;0.166)	Prostate(90;0.109)				ACACTGACGTCTGTCTTGCTG	0.388000													68	196					4.83814e-26	7.30537e-26	1	1	0
LGALS13	29124	broad.mit.edu	37	19	40095993	40095993	+	Missense_Mutation	SNP	G	G	C			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr19:40095993G>C	ENST00000221797.4	+	3	313	c.268G>C	c.(268-270)Gag>Cag	p.E90Q		NM_013268.2	NP_037400.1	Q9UHV8	PP13_HUMAN	lectin, galactoside-binding, soluble, 13	90	Galectin.				lipid catabolic process|phospholipid metabolic process		carboxylesterase activity|lysophospholipase activity|sugar binding			lung(5)|ovary(1)|urinary_tract(1)	7	all_cancers(60;1.77e-05)|all_lung(34;5.38e-08)|Lung NSC(34;6.37e-08)|Ovarian(47;0.116)		Epithelial(26;3.28e-26)|OV - Ovarian serous cystadenocarcinoma(5;7.31e-25)|all cancers(26;1.15e-23)|LUSC - Lung squamous cell carcinoma(53;0.00281)			CAAACAATTTGAGCTGTGCAT	0.512000													20	45					0	0	1	0	0
SALL1	6299	broad.mit.edu	37	16	51175759	51175759	+	Missense_Mutation	SNP	A	A	G			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr16:51175759A>G	ENST00000440970.1	-	2	514	c.83T>C	c.(82-84)aTg>aCg	p.M28T	SALL1_ENST00000541611.1_Intron|SALL1_ENST00000251020.4_Missense_Mutation_p.M125T|SALL1_ENST00000566102.1_Intron	NM_001127892.1	NP_001121364.1	Q9NSC2	SALL1_HUMAN	spalt-like transcription factor 1	125					adrenal gland development|branching involved in ureteric bud morphogenesis|embryonic digestive tract development|embryonic digit morphogenesis|gonad development|histone deacetylation|inductive cell-cell signaling|mesenchymal to epithelial transition involved in metanephros morphogenesis|negative regulation of transcription from RNA polymerase II promoter|olfactory bulb interneuron differentiation|olfactory bulb mitral cell layer development|olfactory nerve development|outer ear morphogenesis|pituitary gland development|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway|ureteric bud invasion|ventricular septum development	chromocenter|cytoplasm|heterochromatin|nucleus	beta-catenin binding|DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(4)|breast(2)|central_nervous_system(2)|endometrium(3)|kidney(5)|large_intestine(25)|lung(61)|ovary(3)|prostate(6)|skin(12)|upper_aerodigestive_tract(3)	126		all_cancers(37;0.0322)	COAD - Colon adenocarcinoma(2;0.24)			CTCCACCTCCATGGACTCTTC	0.547000													9	92					0	0	1	0	0
CCDC93	54520	broad.mit.edu	37	2	118715997	118715997	+	Missense_Mutation	SNP	G	G	C			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr2:118715997G>C	ENST00000376300.2	-	12	1086	c.949C>G	c.(949-951)Cgg>Ggg	p.R317G	CCDC93_ENST00000460781.1_5'UTR|CCDC93_ENST00000319432.5_Missense_Mutation_p.R316G	NM_019044.4	NP_061917.3	Q567U6	CCD93_HUMAN	coiled-coil domain containing 93	317								p.R317G(2)		breast(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(11)|ovary(1)|prostate(2)|skin(2)	29						ATGACTTTCCGGCGATGTAGC	0.398000													7	58					0	0	1	0	0
PVRL3	25945	broad.mit.edu	37	3	110852792	110852792	+	Silent	SNP	A	A	G			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr3:110852792A>G	ENST00000485303.1	+	6	1655	c.1380A>G	c.(1378-1380)caA>caG	p.Q460Q	PVRL3_ENST00000493615.1_Intron|PVRL3_ENST00000319792.3_3'UTR	NM_001243286.1|NM_015480.2	NP_001230215.1|NP_056295.1	Q9NQS3	PVRL3_HUMAN	poliovirus receptor-related 3	460					adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane	cell adhesion molecule binding|protein homodimerization activity			breast(1)|cervix(1)|endometrium(1)|kidney(3)|large_intestine(3)|lung(7)|upper_aerodigestive_tract(3)	19						TTCTTCAACAAGATGAGCTTG	0.363000													9	60					0	0	1	0	0
KIF14	9928	broad.mit.edu	37	1	200571187	200571187	+	Silent	SNP	T	T	C			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr1:200571187T>C	ENST00000367350.4	-	11	2427	c.1989A>G	c.(1987-1989)aaA>aaG	p.K663K		NM_014875.2	NP_055690.1	Q15058	KIF14_HUMAN	kinesin family member 14	663					microtubule-based movement	cytoplasm|microtubule|nucleus|spindle	ATP binding|microtubule motor activity|protein binding			NS(1)|breast(5)|central_nervous_system(2)|endometrium(8)|kidney(8)|large_intestine(15)|lung(13)|ovary(3)|prostate(2)|skin(3)|urinary_tract(1)	61						CCAGACTTTCTTTTAACAGCC	0.343000													9	53					0	0	1	0	0
SNHG14	104472715	broad.mit.edu	37	15	25463718	25463718	+	RNA	SNP	C	C	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr15:25463718C>T	ENST00000424208.1	+	0	2994				SNHG14_ENST00000453082.2_RNA	NR_003305.1																						ATGAGTACATCCGGGTTCCAC	0.562000													28	161					0	0	1	0	0
SLC9A3R1	9368	broad.mit.edu	37	17	72745164	72745164	+	Missense_Mutation	SNP	T	T	G			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr17:72745164T>G	ENST00000262613.5	+	1	374	c.179T>G	c.(178-180)gTg>gGg	p.V60G		NM_004252.4	NP_004243.1	O14745	NHRF1_HUMAN	solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1	60	PDZ 1.				apoptosis|bile acid secretion|glutathione transport|microvillus assembly|negative regulation of cell proliferation|negative regulation of ERK1 and ERK2 cascade|negative regulation of phosphatidylinositol 3-kinase cascade|negative regulation of platelet-derived growth factor receptor signaling pathway|negative regulation of protein kinase B signaling cascade|protein complex assembly|regulation of protein kinase activity|regulation of sodium:hydrogen antiporter activity|renal absorption|Wnt receptor signaling pathway	actin cytoskeleton|apical plasma membrane|centrosome|endomembrane system|filopodium|intracellular membrane-bounded organelle|microvillus membrane|ruffle	beta-2 adrenergic receptor binding|beta-catenin binding|chloride channel regulator activity|growth factor receptor binding|PDZ domain binding|phosphatase binding|protein self-association			large_intestine(4)	4						GACCGGCTGGTGGAGGTGAAC	0.706000													3	10					0	0	1	0	0
PCBP3	54039	broad.mit.edu	37	21	47320983	47320983	+	Missense_Mutation	SNP	G	G	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr21:47320983G>T	ENST00000400314.1	+	7	633	c.295G>T	c.(295-297)Gcc>Tcc	p.A99S	PCBP3_ENST00000400304.1_Missense_Mutation_p.A67S|PCBP3_ENST00000400309.1_Missense_Mutation_p.A99S|PCBP3_ENST00000400308.1_Missense_Mutation_p.A99S|PCBP3_ENST00000449640.1_Missense_Mutation_p.A99S|PCBP3_ENST00000400310.1_Missense_Mutation_p.A99S|PCBP3_ENST00000468429.1_3'UTR			P57721	PCBP3_HUMAN	poly(rC) binding protein 3	99					mRNA metabolic process	cytosol|mitochondrion|nucleus|ribonucleoprotein complex	DNA binding|RNA binding			biliary_tract(1)|endometrium(3)|large_intestine(2)|lung(7)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	17	all_hematologic(128;0.24)			Colorectal(79;0.0411)|READ - Rectum adenocarcinoma(84;0.0649)		CCCCACAGACGCCATCTTCAA	0.587000													17	98					2.48551e-13	3.46145e-13	1	1	0
SCN3A	6328	broad.mit.edu	37	2	165946873	165946873	+	Silent	SNP	C	C	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr2:165946873C>T	ENST00000360093.3	-	28	6281	c.5790G>A	c.(5788-5790)gaG>gaA	p.E1930E	SCN3A_ENST00000283254.7_Silent_p.E1930E|SCN3A_ENST00000409101.3_Silent_p.E1881E|AC013463.2_ENST00000431341.1_RNA|SCN3A_ENST00000540861.1_Silent_p.E413E	NM_001081677.1	NP_001075146.1	Q9NY46	SCN3A_HUMAN	sodium channel, voltage-gated, type III, alpha subunit	1930						voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(1)|breast(7)|central_nervous_system(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(19)|liver(2)|lung(47)|ovary(6)|prostate(3)|skin(10)|upper_aerodigestive_tract(4)|urinary_tract(3)	120					Lamotrigine(DB00555)	CTTTAATTGCCTCTTTGTTAT	0.348000													4	41					0	0	1	0	0
KCNJ14	3770	broad.mit.edu	37	19	48967506	48967506	+	Silent	SNP	A	A	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr19:48967506A>T	ENST00000391884.1	+	2	1259	c.783A>T	c.(781-783)ggA>ggT	p.G261G	KCNJ14_ENST00000342291.2_Silent_p.G261G			Q9UNX9	IRK14_HUMAN	potassium inwardly-rectifying channel, subfamily J, member 14	261						voltage-gated potassium channel complex	inward rectifier potassium channel activity			cervix(1)|endometrium(2)|large_intestine(2)|lung(2)|skin(2)|urinary_tract(1)	10		all_epithelial(76;2.38e-06)|all_lung(116;4.89e-06)|Lung NSC(112;9.34e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.000109)|all cancers(93;0.000129)|Epithelial(262;0.0081)|GBM - Glioblastoma multiforme(486;0.0222)		GCTTTGATGGAGGCACCGATC	0.607000													19	24					0	0	1	0	0
ITGA8	8516	broad.mit.edu	37	10	15600189	15600189	+	Missense_Mutation	SNP	G	G	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr10:15600189G>T	ENST00000378076.3	-	26	3003	c.2650C>A	c.(2650-2652)Cca>Aca	p.P884T		NM_003638.1	NP_003629.1	P53708	ITA8_HUMAN	integrin, alpha 8	884					cell differentiation|cell-cell adhesion|cell-matrix adhesion|integrin-mediated signaling pathway|nervous system development	integrin complex	receptor activity			NS(2)|breast(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(57)|ovary(3)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	96						GTGTCCTCTGGGGAGGCAGCA	0.448000													5	52					0.000602214	0.000652509	1	1	0
PRC1	9055	broad.mit.edu	37	15	91527365	91527365	+	Silent	SNP	G	G	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr15:91527365G>T	ENST00000361188.5	-	3	1361	c.150C>A	c.(148-150)ctC>ctA	p.L50L	PRC1_ENST00000394249.3_Silent_p.L50L|PRC1-AS1_ENST00000554388.1_RNA|PRC1_ENST00000556129.1_5'UTR|PRC1_ENST00000361919.3_Silent_p.L50L|PRC1_ENST00000442656.2_Intron			O43663	PRC1_HUMAN	protein regulator of cytokinesis 1	50	Dimerization.				cytokinesis|mitotic spindle elongation	cytoplasm|nucleus|spindle microtubule|spindle pole	protein binding			endometrium(1)|kidney(2)|large_intestine(7)|lung(9)|ovary(3)|prostate(1)|skin(2)	25	Lung NSC(78;0.0987)|all_lung(78;0.175)					TCATATCCAGGAGTTCCTACA	0.418000													35	210					1.36161e-19	2.00981e-19	1	1	0
DCDC1	341019	broad.mit.edu	37	11	30974028	30974028	+	Nonsense_Mutation	SNP	G	G	C			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr11:30974028G>C	ENST00000597505.1	-	19	2678	c.2679C>G	c.(2677-2679)taC>taG	p.Y893*	DCDC1_ENST00000339794.5_5'UTR|DCDC1_ENST00000406071.2_5'UTR|DCDC1_ENST00000437348.1_Intron			P59894	DCDC1_HUMAN	doublecortin domain containing 1	0					intracellular signal transduction					central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(17)|pancreas(2)|prostate(1)|skin(1)|stomach(1)	31	Lung SC(675;0.225)					CAGGCCACATGTAGGTAAGCT	0.438000													5	29					0	0	1	0	0
CRELD1	78987	broad.mit.edu	37	3	9985088	9985088	+	Missense_Mutation	SNP	G	G	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr3:9985088G>A	ENST00000383811.3	+	9	1536	c.937G>A	c.(937-939)Gtg>Atg	p.V313M	CRELD1_ENST00000489674.1_Intron|CRELD1_ENST00000397170.3_Missense_Mutation_p.V313M|CRELD1_ENST00000452070.1_Missense_Mutation_p.V313M|CRELD1_ENST00000326434.5_Missense_Mutation_p.V313M	NM_015513.4	NP_056328.2	Q96HD1	CREL1_HUMAN	cysteine-rich with EGF-like domains 1	313	EGF-like 2; calcium-binding (Potential).				cardiac septum development|endocardial cushion development	integral to membrane	calcium ion binding			NS(1)|breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(2)|ovary(1)|stomach(1)|urinary_tract(1)	14						TGAGACAGAGGTGTGTCCGGG	0.572000													31	112					0	0	1	0	0
CSK	1445	broad.mit.edu	37	15	75093361	75093361	+	Missense_Mutation	SNP	G	G	C			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr15:75093361G>C	ENST00000220003.9	+	9	1460	c.731G>C	c.(730-732)cGg>cCg	p.R244P	CSK_ENST00000309470.9_Missense_Mutation_p.R244P|CSK_ENST00000567571.1_Missense_Mutation_p.R244P|CSK_ENST00000439220.2_Missense_Mutation_p.R244P	NM_004383.2	NP_004374.1	P41240	CSK_HUMAN	c-src tyrosine kinase	244	Protein kinase.				blood coagulation|epidermal growth factor receptor signaling pathway|T cell costimulation|T cell receptor signaling pathway	centrosome|cytosol|Golgi apparatus	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein C-terminus binding			central_nervous_system(1)|lung(2)	3						AGGCAACTGCGGCATAGCAAC	0.637000													26	131					0	0	1	0	0
FRYL	285527	broad.mit.edu	37	4	48567661	48567661	+	Missense_Mutation	SNP	G	G	C			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr4:48567661G>C	ENST00000537810.1	-	29	3821	c.3217C>G	c.(3217-3219)Cta>Gta	p.L1073V	FRYL_ENST00000503238.1_Missense_Mutation_p.L1073V|FRYL_ENST00000507711.1_Missense_Mutation_p.L1073V|FRYL_ENST00000358350.4_Missense_Mutation_p.L1073V|FRYL_ENST00000264319.7_5'UTR			O94915	FRYL_HUMAN	FRY-like	1073					regulation of transcription, DNA-dependent|transcription, DNA-dependent		protein binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(21)|lung(38)|ovary(1)|pancreas(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	91						AGCATAAATAGACTGTGACGA	0.353000													6	31					0	0	1	0	0
ELTD1	64123	broad.mit.edu	37	1	79387383	79387383	+	Missense_Mutation	SNP	A	A	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr1:79387383A>T	ENST00000370742.3	-	9	1235	c.1172T>A	c.(1171-1173)cTg>cAg	p.L391Q		NM_022159.3	NP_071442.2	Q9HBW9	ELTD1_HUMAN	EGF, latrophilin and seven transmembrane domain containing 1	391	GPS.				neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(1)|breast(1)|endometrium(3)|kidney(2)|large_intestine(10)|lung(45)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	69				COAD - Colon adenocarcinoma(225;0.0905)|Colorectal(170;0.103)|all cancers(265;0.105)|Epithelial(280;0.148)		TGAGTATGTCAGCTCACAGCC	0.428000													125	83					0	0	1	0	0
MS4A5	64232	broad.mit.edu	37	11	60198356	60198356	+	Missense_Mutation	SNP	T	T	C			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr11:60198356T>C	ENST00000300190.2	+	2	327	c.241T>C	c.(241-243)Ttt>Ctt	p.F81L	MS4A5_ENST00000534071.1_Intron	NM_023945.2	NP_076434.2	Q9H3V2	MS4A5_HUMAN	membrane-spanning 4-domains, subfamily A, member 5	81						integral to membrane	receptor activity			large_intestine(7)|lung(7)|ovary(1)|skin(1)	16						AAGGTTTCCCTTTATATTTCT	0.383000													17	88					0	0	1	0	0
DGCR8	54487	broad.mit.edu	37	22	20077225	20077225	+	Missense_Mutation	SNP	A	A	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr22:20077225A>T	ENST00000351989.3	+	4	1343	c.914A>T	c.(913-915)gAc>gTc	p.D305V	DGCR8_ENST00000407755.1_Missense_Mutation_p.D305V|DGCR8_ENST00000383024.2_Missense_Mutation_p.D305V	NM_022720.6	NP_073557.3	Q8WYQ5	DGCR8_HUMAN	DGCR8 microprocessor complex subunit	305	Necessary for heme-binding and pri-miRNA processing.|Necessary for interaction with NCL.|WW.				primary miRNA processing	cytoplasm|microtubule cytoskeleton|nucleolus|nucleoplasm	double-stranded RNA binding|metal ion binding|protein binding			NS(2)|breast(1)|endometrium(5)|large_intestine(5)|lung(7)|skin(1)|upper_aerodigestive_tract(1)	22	Colorectal(54;0.0993)					CCGCTGCCCGACGGGTGGATC	0.542000													23	113					0	0	1	0	0
AGK	55750	broad.mit.edu	37	7	141352706	141352706	+	Silent	SNP	C	C	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr7:141352706C>T	ENST00000355413.4	+	16	1511	c.1251C>T	c.(1249-1251)ctC>ctT	p.L417L	RP5-894A10.2_ENST00000467537.1_RNA|AGK_ENST00000473247.1_Silent_p.L389L	NM_018238.3	NP_060708.1	Q53H12	AGK_HUMAN	acylglycerol kinase	417					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway	mitochondrial membrane	acylglycerol kinase activity|ATP binding|diacylglycerol kinase activity|NAD+ kinase activity			breast(1)|endometrium(1)|large_intestine(4)|lung(6)|ovary(1)|pancreas(1)|prostate(3)	17	Melanoma(164;0.0171)					AACAGATGCTCACAAGCCCCA	0.547000													24	59					0	0	1	0	0
TPO	7173	broad.mit.edu	37	2	1546343	1546343	+	Silent	SNP	A	A	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr2:1546343A>T	ENST00000337415.3	+	16	2860	c.2769A>T	c.(2767-2769)cgA>cgT	p.R923R	TPO_ENST00000382201.3_3'UTR|TPO_ENST00000349624.3_3'UTR|TPO_ENST00000346956.3_3'UTR|TPO_ENST00000345913.4_3'UTR|TPO_ENST00000497517.2_3'UTR|TPO_ENST00000329066.4_3'UTR			P07202	PERT_HUMAN	thyroid peroxidase	0					cellular nitrogen compound metabolic process|hormone biosynthetic process|hydrogen peroxide catabolic process	cell surface|cytoplasm|integral to plasma membrane	calcium ion binding|heme binding|iodide peroxidase activity			breast(1)|central_nervous_system(3)|endometrium(8)|kidney(4)|large_intestine(14)|liver(2)|lung(33)|ovary(8)|pancreas(6)|prostate(4)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	95	all_hematologic(175;0.0487)|Acute lymphoblastic leukemia(172;0.0627)	all_cancers(51;0.0338)		all cancers(51;0.0356)|OV - Ovarian serous cystadenocarcinoma(76;0.0748)|Epithelial(75;0.12)	Carbimazole(DB00389)|Methimazole(DB00763)|Propylthiouracil(DB00550)	CAGCAGGACGACTGTTTTCCC	0.448000													3	8					0	0	1	0	0
SVIL	6840	broad.mit.edu	37	10	29821566	29821566	+	Missense_Mutation	SNP	T	T	C			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr10:29821566T>C	ENST00000375398.2	-	10	2179	c.1730A>G	c.(1729-1731)aAg>aGg	p.K577R	SVIL_ENST00000355867.4_Missense_Mutation_p.K577R|SVIL_ENST00000375400.3_Intron			O95425	SVIL_HUMAN	supervillin	577					cytoskeleton organization|skeletal muscle tissue development	cell junction|costamere|invadopodium|nucleus|podosome	actin filament binding			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(17)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(24)|lung(35)|ovary(8)|prostate(2)|skin(4)|stomach(7)|upper_aerodigestive_tract(2)|urinary_tract(2)	112		Breast(68;0.103)				CCCTTCGGTCTTGGAGCTGGG	0.592000													17	67					0	0	1	0	0
SDR42E1	93517	broad.mit.edu	37	16	82033255	82033255	+	Missense_Mutation	SNP	C	C	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr16:82033255C>A	ENST00000328945.5	-	3	770	c.643G>T	c.(643-645)Gac>Tac	p.D215Y		NM_145168.2	NP_660151.2	Q8WUS8	D42E1_HUMAN	short chain dehydrogenase/reductase family 42E, member 1	215					steroid biosynthetic process	integral to membrane	3-beta-hydroxy-delta5-steroid dehydrogenase activity|binding			NS(2)|endometrium(1)|lung(4)|skin(3)	10						CTCCTGGGGTCCCCGTAGACA	0.552000													31	129					1.13719e-10	1.50103e-10	1	1	0
TTC21B	79809	broad.mit.edu	37	2	166771822	166771822	+	Missense_Mutation	SNP	A	A	C			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr2:166771822A>C	ENST00000243344.7	-	15	2164	c.2027T>G	c.(2026-2028)aTc>aGc	p.I676S		NM_024753.4	NP_079029.3	Q7Z4L5	TT21B_HUMAN	tetratricopeptide repeat domain 21B	676						cilium axoneme|cytoplasm|cytoskeleton	binding			breast(2)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(9)|lung(28)|ovary(2)|pancreas(2)|skin(2)|urinary_tract(1)	58						ATTCTGAAGGATGCTTAAAGC	0.398000													54	144					0	0	1	0	0
MGAT3	4248	broad.mit.edu	37	22	39884744	39884744	+	Missense_Mutation	SNP	G	G	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr22:39884744G>T	ENST00000341184.6	+	2	1607	c.1392G>T	c.(1390-1392)tgG>tgT	p.W464C		NM_001098270.1|NM_002409.4	NP_001091740.1|NP_002400.3	Q09327	MGAT3_HUMAN	mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase	464					post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	beta-1,4-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity			endometrium(4)|kidney(1)|large_intestine(5)|lung(12)|prostate(1)|skin(1)	24	Melanoma(58;0.04)					CCGGGGGCTGGTTCGACGGCA	0.637000													5	27					3.59834e-05	4.04556e-05	1	1	0
UBQLN2	29978	broad.mit.edu	37	X	56591882	56591882	+	Missense_Mutation	SNP	G	G	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chrX:56591882G>T	ENST00000338222.5	+	1	1857	c.1576G>T	c.(1576-1578)Ggc>Tgc	p.G526C		NM_013444.3	NP_038472.2	Q9UHD9	UBQL2_HUMAN	ubiquilin 2	526	12 X 3 AA tandem repeats of P-X-X.					cytoplasm|nucleus|plasma membrane	binding			breast(2)|endometrium(3)|large_intestine(4)|lung(8)|ovary(2)|prostate(1)|skin(1)	21						AGCCCCCCCTGGCTCCACCGG	0.632000													6	6					2.7689e-08	3.49569e-08	1	1	0
NRIP1	8204	broad.mit.edu	37	21	16339463	16339463	+	Missense_Mutation	SNP	C	C	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr21:16339463C>A	ENST00000400202.1	-	3	1763	c.1051G>T	c.(1051-1053)Ggt>Tgt	p.G351C	NRIP1_ENST00000400199.1_Missense_Mutation_p.G351C|NRIP1_ENST00000318948.4_Missense_Mutation_p.G351C			P48552	NRIP1_HUMAN	nuclear receptor interacting protein 1	351					androgen receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		androgen receptor binding|estrogen receptor binding|glucocorticoid receptor binding|transcription coactivator activity|transcription corepressor activity			cervix(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(6)|lung(13)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(4)	39				Epithelial(23;1.19e-05)|all cancers(11;4.64e-05)|COAD - Colon adenocarcinoma(22;0.000232)|Colorectal(24;0.0006)|OV - Ovarian serous cystadenocarcinoma(11;0.00418)|Lung(58;0.199)|LUSC - Lung squamous cell carcinoma(23;0.24)		GGAATGATACCCATTGGATTT	0.373000													14	59					4.3838e-07	5.26483e-07	1	1	0
CHD5	26038	broad.mit.edu	37	1	6203951	6203951	+	Missense_Mutation	SNP	G	G	C			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr1:6203951G>C	ENST00000262450.3	-	13	2074	c.1975C>G	c.(1975-1977)Ctg>Gtg	p.L659V	CHD5_ENST00000378021.1_5'UTR	NM_015557.2	NP_056372.1	Q8TDI0	CHD5_HUMAN	chromodomain helicase DNA binding protein 5	659					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|DNA binding|zinc ion binding			breast(3)|central_nervous_system(3)|liver(1)|lung(1)|ovary(4)|pancreas(1)|skin(1)|upper_aerodigestive_tract(2)	16	Ovarian(185;0.0634)	all_cancers(23;5.36e-32)|all_epithelial(116;2.32e-17)|all_neural(13;3.68e-06)|all_lung(118;3.94e-06)|all_hematologic(16;2.39e-05)|Lung NSC(185;5.33e-05)|Acute lymphoblastic leukemia(12;0.000372)|Glioma(11;0.00127)|Renal(390;0.00188)|Colorectal(325;0.00342)|Breast(487;0.00373)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.15)		Epithelial(90;3.08e-37)|GBM - Glioblastoma multiforme(13;1.36e-31)|OV - Ovarian serous cystadenocarcinoma(86;7.7e-19)|Colorectal(212;9.97e-08)|COAD - Colon adenocarcinoma(227;1.07e-05)|Kidney(185;6.16e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.00109)|BRCA - Breast invasive adenocarcinoma(365;0.0012)|STAD - Stomach adenocarcinoma(132;0.00346)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.193)		TTCTTGAGCAGCCTCTTGGGC	0.647000													21	113					0	0	1	0	0
SIRPG	55423	broad.mit.edu	37	20	1617044	1617044	+	Silent	SNP	G	G	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr20:1617044G>A	ENST00000381580.1	-	3	618	c.439C>T	c.(439-441)Ctg>Ttg	p.L147L	SIRPG_ENST00000303415.3_Silent_p.L180L|SIRPG_ENST00000344103.4_Intron|RP11-77C3.3_ENST00000456177.1_RNA|SIRPG_ENST00000216927.4_Silent_p.L180L|SIRPG_ENST00000381583.2_Silent_p.L180L			Q9P1W8	SIRPG_HUMAN	signal-regulatory protein gamma	180	Ig-like C1-type 1.				blood coagulation|cell adhesion|cell junction assembly|cell-cell signaling|intracellular signal transduction|leukocyte migration|negative regulation of cell proliferation|positive regulation of cell proliferation|positive regulation of cell-cell adhesion|positive regulation of T cell activation	integral to membrane|intracellular|plasma membrane	protein binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(14)|ovary(1)|prostate(2)|stomach(1)	27						AACCATTTCAGGGTGATGTCT	0.572000													45	94					0	0	1	0	0
LILRP2	79166	broad.mit.edu	37	19	55224690	55224690	+	RNA	SNP	G	G	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr19:55224690G>A	ENST00000413439.1	+	0	1862																											GCTGCTTTAGGATTGGCACAG	0.542000													7	16					0	0	1	0	0
FBXL17	64839	broad.mit.edu	37	5	107216681	107216681	+	Missense_Mutation	SNP	C	C	G			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr5:107216681C>G	ENST00000496714.1	-	7	1029	c.828G>C	c.(826-828)ttG>ttC	p.L276F	FBXL17_ENST00000359660.5_Intron|FBXL17_ENST00000542267.1_Intron			Q9UF56	FXL17_HUMAN	F-box and leucine-rich repeat protein 17	0										endometrium(1)|large_intestine(4)|lung(1)	6		all_cancers(142;0.00273)|all_epithelial(76;0.000362)|Prostate(80;0.0115)|Myeloproliferative disorder(839;0.0393)|Ovarian(225;0.232)		OV - Ovarian serous cystadenocarcinoma(64;9.63e-11)|Epithelial(69;4.02e-10)		GATATGACATCAAGCTATTAA	0.338000													11	72					0	0	1	0	0
GIN1	54826	broad.mit.edu	37	5	102440274	102440274	+	Missense_Mutation	SNP	T	T	G			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr5:102440274T>G	ENST00000399004.2	-	4	704	c.610A>C	c.(610-612)Atg>Ctg	p.M204L	GIN1_ENST00000508629.1_Missense_Mutation_p.M204L|GIN1_ENST00000511400.1_5'UTR	NM_017676.2	NP_060146.2	Q9NXP7	GIN1_HUMAN	gypsy retrotransposon integrase 1	204	Integrase catalytic.				DNA integration		DNA binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(8)|ovary(1)|prostate(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	25		all_cancers(142;3.23e-07)|all_epithelial(76;3.64e-10)|Prostate(80;0.00914)|Ovarian(225;0.0139)|Lung NSC(167;0.0212)|Colorectal(57;0.0249)|all_lung(232;0.0283)		Epithelial(69;3.57e-14)|COAD - Colon adenocarcinoma(37;0.00794)		CTTTGGTCCATTATTATTTTC	0.353000													4	21					0	0	1	0	0
ATP6AP1L	92270	broad.mit.edu	37	5	81608566	81608566	+	Missense_Mutation	SNP	C	C	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr5:81608566C>T	ENST00000380167.4	+	9	1593	c.268C>T	c.(268-270)Cgc>Tgc	p.R90C	ATP6AP1L_ENST00000439350.1_Missense_Mutation_p.R90C|ATP6AP1L_ENST00000508366.1_3'UTR			Q52LC2	VAS1L_HUMAN	ATPase, H+ transporting, lysosomal accessory protein 1-like	90					ATP hydrolysis coupled proton transport	integral to membrane|proton-transporting V-type ATPase, V1 domain	hydrogen ion transporting ATP synthase activity, rotational mechanism|proton-transporting ATPase activity, rotational mechanism			breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(4)|urinary_tract(1)	12						TTACTCCTACCGCTGCCAACG	0.537000											OREG0016689	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	30	122					0	0	1	0	0
OR52E4	390081	broad.mit.edu	37	11	5906320	5906320	+	Silent	SNP	C	C	G			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr11:5906320C>G	ENST00000316987.2	+	1	820	c.798C>G	c.(796-798)ggC>ggG	p.G266G		NM_001005165.1	NP_001005165.1	Q8NGH9	O52E4_HUMAN	olfactory receptor, family 52, subfamily E, member 4	266					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			autonomic_ganglia(1)|endometrium(1)|kidney(1)|large_intestine(7)|liver(2)|lung(13)|ovary(2)|prostate(1)|skin(2)	30		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;1.24e-08)|BRCA - Breast invasive adenocarcinoma(625;0.135)		ATCGTTTTGGCCAAAACATTC	0.428000													14	79					0	0	1	0	0
TNPO3	23534	broad.mit.edu	37	7	128658072	128658072	+	Missense_Mutation	SNP	C	C	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr7:128658072C>T	ENST00000393245.1	-	2	633	c.260G>A	c.(259-261)cGg>cAg	p.R87Q	TNPO3_ENST00000471234.1_Missense_Mutation_p.R87Q|TNPO3_ENST00000471166.1_Missense_Mutation_p.R87Q|TNPO3_ENST00000482320.1_Missense_Mutation_p.R21Q|TNPO3_ENST00000265388.5_Missense_Mutation_p.R87Q	NM_012470.3	NP_036602.1	Q9Y5L0	TNPO3_HUMAN	transportin 3	87				R -> W (in Ref. 1; AAD38537).	splicing factor protein import into nucleus	cytoplasm|nucleus	protein binding|receptor activity			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(2)|lung(7)|ovary(2)|prostate(2)|skin(3)	22						CAATGAGTCCCGTAAAGAGGC	0.438000													12	83					0	0	1	0	0
GRM1	2911	broad.mit.edu	37	6	146350979	146350979	+	Missense_Mutation	SNP	G	G	C			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr6:146350979G>C	ENST00000392299.2	+	2	796	c.326G>C	c.(325-327)tGc>tCc	p.C109S	GRM1_ENST00000507907.1_Missense_Mutation_p.C109S|GRM1_ENST00000355289.4_Missense_Mutation_p.C109S|GRM1_ENST00000361719.2_Missense_Mutation_p.C109S|GRM1_ENST00000492807.2_Missense_Mutation_p.C109S|GRM1_ENST00000282753.1_Missense_Mutation_p.C109S			Q13255	GRM1_HUMAN	glutamate receptor, metabotropic 1	109					synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			NS(2)|breast(5)|central_nervous_system(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(54)|ovary(7)|pancreas(2)|prostate(5)|skin(7)|upper_aerodigestive_tract(4)|urinary_tract(1)	126		Ovarian(120;0.0387)		OV - Ovarian serous cystadenocarcinoma(155;5.35e-08)|GBM - Glioblastoma multiforme(68;0.00762)	Acamprosate(DB00659)|L-Glutamic Acid(DB00142)	CGGGACTCCTGCTGGCACTCT	0.557000													16	54					0	0	1	0	0
ITGA8	8516	broad.mit.edu	37	10	15714731	15714731	+	Missense_Mutation	SNP	T	T	C			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr10:15714731T>C	ENST00000378076.3	-	7	1047	c.694A>G	c.(694-696)Agt>Ggt	p.S232G		NM_003638.1	NP_003629.1	P53708	ITA8_HUMAN	integrin, alpha 8	232					cell differentiation|cell-cell adhesion|cell-matrix adhesion|integrin-mediated signaling pathway|nervous system development	integrin complex	receptor activity			NS(2)|breast(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(57)|ovary(3)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	96						TCTGCAACACTGGCAGTGATC	0.448000													11	55					0	0	1	0	0
CLK2	1196	broad.mit.edu	37	1	155235708	155235708	+	Missense_Mutation	SNP	C	C	G			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr1:155235708C>G	ENST00000368361.4	-	8	1191	c.876G>C	c.(874-876)aaG>aaC	p.K292N	CLK2_ENST00000497188.1_5'UTR|CLK2_ENST00000361168.5_Missense_Mutation_p.K291N|CLK2_ENST00000536801.1_Missense_Mutation_p.K292N|CLK2_ENST00000355560.4_Missense_Mutation_p.K290N			P49760	CLK2_HUMAN	CDC-like kinase 2	292	Protein kinase.					nucleus	ATP binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			endometrium(4)|lung(12)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	22	all_lung(78;2.32e-23)|Hepatocellular(266;0.0877)|all_hematologic(923;0.088)		Epithelial(20;3.72e-10)|all cancers(21;1.19e-09)|BRCA - Breast invasive adenocarcinoma(34;0.000752)|LUSC - Lung squamous cell carcinoma(543;0.193)			TATTTTCAGGCTTGAGGTCTG	0.502000								Other conserved DNA damage response genes					63	116					0	0	1	0	0
PMFBP1	83449	broad.mit.edu	37	16	72166693	72166693	+	Missense_Mutation	SNP	C	C	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr16:72166693C>A	ENST00000537465.1	-	10	1559	c.1401G>T	c.(1399-1401)aaG>aaT	p.K467N	PMFBP1_ENST00000237353.10_Missense_Mutation_p.K467N|PMFBP1_ENST00000355636.6_Missense_Mutation_p.K322N			Q8TBY8	PMFBP_HUMAN	polyamine modulated factor 1 binding protein 1	467										NS(1)|breast(3)|endometrium(1)|kidney(2)|large_intestine(7)|lung(25)|ovary(2)|skin(3)|urinary_tract(1)	45		Ovarian(137;0.179)				TGTTCTTCAGCTTCTGGACCT	0.587000													70	146					6.25564e-26	9.43129e-26	1	1	0
BCAR1	9564	broad.mit.edu	37	16	75276842	75276842	+	Silent	SNP	G	G	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr16:75276842G>T	ENST00000546196.1	-	2	1724	c.72C>A	c.(70-72)ggC>ggA	p.G24G	BCAR1_ENST00000162330.5_Silent_p.G53G|BCAR1_ENST00000420641.3_Silent_p.G71G|BCAR1_ENST00000542031.2_Silent_p.G51G|BCAR1_ENST00000538440.2_Silent_p.G53G|BCAR1_ENST00000535626.2_Silent_p.G53G|BCAR1_ENST00000393422.2_Silent_p.G71G|BCAR1_ENST00000418647.3_Silent_p.G99G|BCAR1_ENST00000393420.6_Silent_p.G53G			P56945	BCAR1_HUMAN	breast cancer anti-estrogen resistance 1	53	SH3.				actin filament organization|B cell receptor signaling pathway|blood coagulation|cell adhesion|cell division|cell migration|cell proliferation|epidermal growth factor receptor signaling pathway|G-protein coupled receptor protein signaling pathway|insulin receptor signaling pathway|integrin-mediated signaling pathway|nerve growth factor receptor signaling pathway|platelet-derived growth factor receptor signaling pathway|positive regulation of cell migration|regulation of apoptosis|regulation of cell growth|T cell receptor signaling pathway	cytosol|focal adhesion|membrane fraction|ruffle	protein kinase binding|protein phosphatase binding|SH3 domain binding|signal transducer activity			breast(2)|central_nervous_system(5)|endometrium(1)|kidney(6)|large_intestine(1)|liver(1)|lung(13)|ovary(1)|prostate(3)|upper_aerodigestive_tract(2)	35				BRCA - Breast invasive adenocarcinoma(221;0.169)		CAGGCACGATGCCCTGGCGCC	0.667000													8	86					3.86212e-05	4.31752e-05	1	1	0
MAST2	23139	broad.mit.edu	37	1	46501239	46501239	+	Missense_Mutation	SNP	G	G	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr1:46501239G>T	ENST00000361297.2	+	29	5181	c.4898G>T	c.(4897-4899)aGc>aTc	p.S1633I	MAST2_ENST00000372009.2_Missense_Mutation_p.S1443I|MAST2_ENST00000372008.1_Intron	NM_015112.2	NP_055927.2	Q6P0Q8	MAST2_HUMAN	microtubule associated serine/threonine kinase 2	1633					regulation of interleukin-12 biosynthetic process|spermatid differentiation	cytoplasm|cytoskeleton|plasma membrane	ATP binding|magnesium ion binding|phosphatase binding|protein serine/threonine kinase activity			breast(1)|lung(3)|ovary(5)|stomach(2)	11	Acute lymphoblastic leukemia(166;0.155)|Lung SC(450;0.184)					CTTTCTCCCAGCACTTCGGGA	0.602000													33	69					1.36161e-19	2.00981e-19	1	1	0
SYNE1	23345	broad.mit.edu	37	6	152755061	152755061	+	Missense_Mutation	SNP	C	C	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr6:152755061C>T	ENST00000367255.5	-	34	4931	c.4330G>A	c.(4330-4332)Gtg>Atg	p.V1444M	SYNE1_ENST00000448038.1_Missense_Mutation_p.V1451M|SYNE1_ENST00000367253.4_Missense_Mutation_p.V1444M|SYNE1_ENST00000265368.4_Missense_Mutation_p.V1444M|SYNE1_ENST00000341594.5_Missense_Mutation_p.V1514M|SYNE1_ENST00000367248.3_3'UTR|SYNE1_ENST00000423061.1_Missense_Mutation_p.V1451M	NM_182961.3	NP_892006.3	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	1444					cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			NS(3)|biliary_tract(1)|breast(17)|central_nervous_system(21)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(4)|kidney(16)|large_intestine(138)|liver(1)|lung(190)|ovary(11)|pancreas(5)|prostate(12)|skin(20)|stomach(3)|upper_aerodigestive_tract(33)|urinary_tract(19)	524		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		TTGGTTTTCACCATTTCCATG	0.338000										HNSCC(10;0.0054)			9	38					0	0	1	0	0
YIPF5	81555	broad.mit.edu	37	5	143539985	143539985	+	Silent	SNP	G	G	A	rs35108266		TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr5:143539985G>A	ENST00000274496.5	-	6	884	c.750C>T	c.(748-750)gtC>gtT	p.V250V	YIPF5_ENST00000448443.2_Silent_p.V250V|YIPF5_ENST00000513112.1_Silent_p.V196V	NM_001271732.1|NM_030799.7	NP_001258661.1|NP_110426.4	Q969M3	YIPF5_HUMAN	Yip1 domain family, member 5	250					protein transport|vesicle-mediated transport	endoplasmic reticulum membrane|ER to Golgi transport vesicle|Golgi cisterna membrane|integral to membrane				large_intestine(2)|lung(5)|ovary(1)|skin(1)	9		all_hematologic(541;0.118)	KIRC - Kidney renal clear cell carcinoma(527;0.00111)|Kidney(363;0.00176)			TCAGGGCAAAGACTCCATATA	0.393000													15	63					0	0	1	0	0
PTGER4	5734	broad.mit.edu	37	5	40681161	40681161	+	Silent	SNP	C	C	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr5:40681161C>T	ENST00000302472.3	+	2	1090	c.66C>T	c.(64-66)acC>acT	p.T22T	PTGER4_ENST00000514343.1_3'UTR	NM_000958.2	NP_000949.1	P35408	PE2R4_HUMAN	prostaglandin E receptor 4 (subtype EP4)	22					G-protein signaling, coupled to cAMP nucleotide second messenger|immune response	integral to membrane|plasma membrane	prostaglandin E receptor activity			breast(1)|endometrium(3)|liver(1)|lung(13)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	23						GCCCAGTGACCATCCCGGCGG	0.622000											OREG0016588	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	29	136					0	0	1	0	0
ARHGAP27	201176	broad.mit.edu	37	17	43475384	43475384	+	Silent	SNP	C	C	G			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr17:43475384C>G	ENST00000532038.1	-	9	1242	c.1107G>C	c.(1105-1107)ctG>ctC	p.L369L	ARHGAP27_ENST00000532891.2_Silent_p.L569L|ARHGAP27_ENST00000442348.1_Silent_p.L564L|ARHGAP27_ENST00000428638.1_Silent_p.L591L|ARHGAP27_ENST00000528384.1_Silent_p.L223L|ARHGAP27_ENST00000455881.1_Silent_p.L250L|ARHGAP27_ENST00000376922.2_Silent_p.L250L|ARHGAP27_ENST00000582826.1_5'UTR			Q6ZUM4	RHG27_HUMAN	Rho GTPase activating protein 27	591					positive regulation of Cdc42 GTPase activity|receptor-mediated endocytosis|signal transduction	cytoplasm|membrane	Rac GTPase activator activity|SH3 domain binding			endometrium(4)|large_intestine(9)|lung(3)|skin(1)	17	Renal(3;0.0405)					CGTGCTGGATCAGGTACTCAG	0.617000													15	80					0	0	1	0	0
PARVG	64098	broad.mit.edu	37	22	44602230	44602230	+	Missense_Mutation	SNP	G	G	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr22:44602230G>T	ENST00000422871.1	+	14	1344	c.920G>T	c.(919-921)aGg>aTg	p.R307M	PARVG_ENST00000444313.2_Missense_Mutation_p.R307M|PARVG_ENST00000415224.1_Missense_Mutation_p.R307M	NM_001137605.1	NP_001131077.1	Q9HBI0	PARVG_HUMAN	parvin, gamma	307	CH 2.				cell-matrix adhesion	cytoplasm|cytoskeleton|focal adhesion	actin binding			endometrium(2)|kidney(1)|large_intestine(4)|lung(10)	17		Ovarian(80;0.024)|all_neural(38;0.0299)				AGCACACTGAGGGTGCTCTAT	0.607000													10	63					1.5842e-08	2.01032e-08	1	1	0
DSCAM	1826	broad.mit.edu	37	21	42080487	42080487	+	Missense_Mutation	SNP	G	G	C			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr21:42080487G>C	ENST00000400454.1	-	2	731	c.254C>G	c.(253-255)cCc>cGc	p.P85R		NM_001389.3	NP_001380.2	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule	85	Ig-like C2-type 1.				cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(22)|lung(47)|ovary(7)|pancreas(2)|prostate(3)|skin(14)|upper_aerodigestive_tract(6)|urinary_tract(4)	142		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				AGGAGGGAAGGGGAAAATTTG	0.498000													19	106					0	0	1	0	0
RP11-146E13.4	0	broad.mit.edu	37	14	19857025	19857025	+	RNA	SNP	C	C	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr14:19857025C>T	ENST00000548109.1	+	0	72																											CTCTCAGCATCCTGGATAATA	0.383000													22	132					0	0	1	0	0
TOPORS	10210	broad.mit.edu	37	9	32544225	32544225	+	Missense_Mutation	SNP	C	C	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr9:32544225C>T	ENST00000360538.2	-	3	414	c.298G>A	c.(298-300)Gat>Aat	p.D100N	TOPORS_ENST00000379858.1_Missense_Mutation_p.D35N	NM_005802.4	NP_005793.2	Q9NS56	TOPRS_HUMAN	topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase	100	E3 ubiquitin-protein ligase activity.|Required for DNA-binding.				DNA damage response, signal transduction resulting in induction of apoptosis|maintenance of protein location in nucleus|proteasomal ubiquitin-dependent protein catabolic process|protein sumoylation|transcription, DNA-dependent	nuclear speck|PML body	antigen binding|DNA binding|DNA topoisomerase I binding|SUMO ligase activity|ubiquitin-protein ligase activity|zinc ion binding			large_intestine(6)|ovary(3)|skin(2)|upper_aerodigestive_tract(1)	12			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.0018)		CACTTAGAATCAGGAGATGCA	0.398000													24	56					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179553414	179553414	+	Silent	SNP	C	C	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr2:179553414C>T	ENST00000589042.1	-	126	32411	c.32187G>A	c.(32185-32187)acG>acA	p.T10729T	TTN_ENST00000342175.6_Intron|TTN-AS1_ENST00000589830.1_RNA|TTN_ENST00000359218.5_Intron|TTN-AS1_ENST00000431752.1_RNA|TTN-AS1_ENST00000589487.1_RNA|TTN_ENST00000591111.1_Silent_p.T10412T|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000342992.6_Silent_p.T9485T|TTN_ENST00000460472.2_Intron|TTN-AS1_ENST00000592630.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	10412	Glu-rich.|Pro-rich.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CTTCGTGCCGCGTGACTTCCA	0.388000													7	50					0	0	1	0	0
SLC2A14	144195	broad.mit.edu	37	12	7981302	7981302	+	Missense_Mutation	SNP	C	C	G			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr12:7981302C>G	ENST00000543909.1	-	11	1502	c.743G>C	c.(742-744)cGg>cCg	p.R248P	SLC2A14_ENST00000396589.2_Missense_Mutation_p.R248P|SLC2A14_ENST00000542505.1_Intron|SLC2A14_ENST00000535295.1_Missense_Mutation_p.R139P|SLC2A14_ENST00000431042.2_Missense_Mutation_p.R225P|SLC2A14_ENST00000539924.1_Missense_Mutation_p.R263P|SLC2A14_ENST00000340749.5_Missense_Mutation_p.R225P|SLC2A14_ENST00000542546.1_Missense_Mutation_p.R139P			Q8TDB8	GTR14_HUMAN	solute carrier family 2 (facilitated glucose transporter), member 14	248					cell differentiation|multicellular organismal development|spermatogenesis	integral to membrane	glucose transmembrane transporter activity			central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(9)|lung(12)|ovary(2)|prostate(1)|skin(1)|stomach(3)|upper_aerodigestive_tract(1)	38				Kidney(36;0.0883)		ATACTCACTCCGCGTAGCATT	0.433000													18	99					0	0	1	0	0
PDZRN3	23024	broad.mit.edu	37	3	73433873	73433873	+	Missense_Mutation	SNP	C	C	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr3:73433873C>A	ENST00000263666.4	-	10	1958	c.1844G>T	c.(1843-1845)aGc>aTc	p.S615I	PDZRN3_ENST00000466780.1_Missense_Mutation_p.S272I|PDZRN3_ENST00000479530.1_Missense_Mutation_p.S332I|PDZRN3_ENST00000535920.1_Missense_Mutation_p.S337I|PDZRN3_ENST00000462146.2_Missense_Mutation_p.S272I	NM_015009.1	NP_055824.1	Q9UPQ7	PZRN3_HUMAN	PDZ domain containing ring finger 3	615							ubiquitin-protein ligase activity|zinc ion binding			breast(2)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(13)|lung(31)|ovary(4)|pancreas(2)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	69		Prostate(10;0.114)|Lung NSC(201;0.187)|Lung SC(41;0.236)		BRCA - Breast invasive adenocarcinoma(55;0.00041)|Epithelial(33;0.0023)|LUSC - Lung squamous cell carcinoma(21;0.0048)|Lung(16;0.0105)|KIRC - Kidney renal clear cell carcinoma(39;0.111)|Kidney(39;0.134)		CAGGTCGCCGCTGCCCAAGGT	0.657000													20	85					5.03518e-11	6.77311e-11	1	1	0
RFWD3	55159	broad.mit.edu	37	16	74666542	74666542	+	Missense_Mutation	SNP	T	T	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr16:74666542T>A	ENST00000361070.4	-	9	1553	c.1456A>T	c.(1456-1458)Aac>Tac	p.N486Y	RFWD3_ENST00000571750.1_Missense_Mutation_p.N486Y	NM_018124.3	NP_060594.3	Q6PCD5	RFWD3_HUMAN	ring finger and WD repeat domain 3	486					DNA repair|mitotic cell cycle G1/S transition DNA damage checkpoint|response to ionizing radiation	nucleus	MDM2 binding|p53 binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|breast(1)|endometrium(3)|kidney(1)|large_intestine(3)|lung(12)|ovary(1)|skin(2)|stomach(1)|urinary_tract(1)	26						CTCTTCATGTTGGCAGTACTC	0.428000													26	48					0	0	1	0	0
UNC80	285175	broad.mit.edu	37	2	210642095	210642095	+	Missense_Mutation	SNP	G	G	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr2:210642095G>T	ENST00000439458.1	+	4	492	c.412G>T	c.(412-414)Ggc>Tgc	p.G138C	UNC80_ENST00000478701.1_3'UTR|UNC80_ENST00000272845.5_Missense_Mutation_p.G138C	NM_032504.1	NP_115893.1	Q8N2C7	UNC80_HUMAN	unc-80 homolog (C. elegans)	138						integral to membrane				breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(9)|ovary(1)|prostate(1)	20						TACAGACCGAGGCTCCAGCTG	0.552000													20	81					3.99206e-14	5.5991e-14	1	1	0
PAK7	57144	broad.mit.edu	37	20	9546559	9546559	+	Missense_Mutation	SNP	C	C	G			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr20:9546559C>G	ENST00000378429.3	-	6	2009	c.1463G>C	c.(1462-1464)cGa>cCa	p.R488P	PAK7_ENST00000353224.5_Missense_Mutation_p.R488P|PAK7_ENST00000378423.1_Missense_Mutation_p.R488P	NM_020341.3	NP_065074.1	Q9P286	PAK7_HUMAN	p21 protein (Cdc42/Rac)-activated kinase 7	488	Protein kinase.						ATP binding|protein binding|protein serine/threonine kinase activity			NS(1)|central_nervous_system(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(44)|ovary(2)|skin(13)|stomach(1)|upper_aerodigestive_tract(3)	81			COAD - Colon adenocarcinoma(9;0.194)			AAGCAGTTCTCGTCTCTGTTG	0.433000													55	200					0	0	1	0	0
CDCA2	157313	broad.mit.edu	37	8	25318021	25318021	+	Silent	SNP	C	C	G	rs116086438	by1000genomes	TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr8:25318021C>G	ENST00000330560.3	+	3	660	c.183C>G	c.(181-183)acC>acG	p.T61T	CDCA2_ENST00000380665.3_Silent_p.T46T	NM_152562.2	NP_689775.2	Q69YH5	CDCA2_HUMAN	cell division cycle associated 2	61					cell division|mitosis	cytoplasm|nucleus				breast(3)|cervix(1)|endometrium(3)|kidney(7)|large_intestine(7)|lung(10)|ovary(1)|prostate(3)	35		all_cancers(63;0.0378)|Ovarian(32;0.000878)|all_epithelial(46;0.0162)|Breast(100;0.0164)|Prostate(55;0.191)		UCEC - Uterine corpus endometrioid carcinoma (27;0.022)|Epithelial(17;1.37e-11)|Colorectal(74;0.0129)|COAD - Colon adenocarcinoma(73;0.0443)		CCACAGTAACCGTAGAGCAAT	0.383000													17	91					0	0	1	0	0
OR2T6	254879	broad.mit.edu	37	1	248551037	248551037	+	Missense_Mutation	SNP	G	G	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr1:248551037G>T	ENST00000355728.2	+	1	128	c.128G>T	c.(127-129)gGg>gTg	p.G43V		NM_001005471.1	NP_001005471.1	Q8NHC8	OR2T6_HUMAN	olfactory receptor, family 2, subfamily T, member 6	43					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|large_intestine(5)|lung(38)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	55	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			ATAGCTAATGGGGTCATGATC	0.473000													20	108					1.15919e-05	1.33057e-05	1	1	0
ZNF513	130557	broad.mit.edu	37	2	27600829	27600829	+	Silent	SNP	C	C	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr2:27600829C>T	ENST00000323703.6	-	4	1407	c.1209G>A	c.(1207-1209)ctG>ctA	p.L403L	ZNF513_ENST00000407879.1_Silent_p.L341L|ZNF513_ENST00000491924.1_5'UTR	NM_144631.5	NP_653232.3	Q8N8E2	ZN513_HUMAN	zinc finger protein 513	403					regulation of transcription, DNA-dependent|response to stimulus|retina development in camera-type eye|transcription, DNA-dependent|visual perception	nucleus	transcription regulatory region DNA binding|zinc ion binding			endometrium(5)|kidney(1)|large_intestine(2)|lung(7)|ovary(2)	17	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GGTGCCGTTTCAGGTTATCCA	0.587000													40	192					0	0	1	0	0
XIRP1	165904	broad.mit.edu	37	3	39230561	39230561	+	Missense_Mutation	SNP	T	T	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr3:39230561T>A	ENST00000340369.3	-	2	604	c.376A>T	c.(376-378)Acc>Tcc	p.T126S	XIRP1_ENST00000421646.1_Intron|XIRP1_ENST00000396251.1_Missense_Mutation_p.T126S	NM_194293.2	NP_919269.2	Q702N8	XIRP1_HUMAN	xin actin-binding repeat containing 1	126							actin binding			breast(4)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(14)|lung(22)|ovary(4)|pancreas(1)|prostate(2)|skin(6)	71				KIRC - Kidney renal clear cell carcinoma(284;0.0517)|Kidney(284;0.065)		TTGCGGGAGGTGGCCTGGACG	0.617000													11	73					0	0	1	0	0
RBM6	10180	broad.mit.edu	37	3	50102541	50102541	+	Silent	SNP	G	G	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr3:50102541G>A	ENST00000443081.1	+	16	3187	c.2268G>A	c.(2266-2268)aaG>aaA	p.K756K	RBM6_ENST00000441115.1_3'UTR|RBM6_ENST00000266022.4_Silent_p.K888K|RBM6_ENST00000539992.1_Silent_p.K230K|RBM6_ENST00000442092.1_Silent_p.K366K|RBM6_ENST00000422955.1_Silent_p.K366K			P78332	RBM6_HUMAN	RNA binding motif protein 6	888					RNA processing	nucleus	DNA binding|nucleotide binding|RNA binding|zinc ion binding			breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(10)|ovary(3)|prostate(1)|skin(4)|urinary_tract(1)	33				BRCA - Breast invasive adenocarcinoma(193;6.81e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.0084)|Kidney(197;0.00977)		CTGTGAAGAAGGAAGAGAGTC	0.537000													19	87					0	0	1	0	0
PCDHA5	56143	broad.mit.edu	37	5	140202981	140202981	+	Missense_Mutation	SNP	G	G	T	rs17844295		TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr5:140202981G>T	ENST00000529859.1	+	1	1621	c.1621G>T	c.(1621-1623)Gtg>Ttg	p.V541L	PCDHA5_ENST00000378126.3_Missense_Mutation_p.V541L|PCDHA5_ENST00000529619.1_Missense_Mutation_p.V541L|PCDHA1_ENST00000504120.2_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA1_ENST00000394633.3_Intron	NM_018908.2	NP_061731.1														NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(4)|kidney(6)|large_intestine(8)|liver(1)|lung(22)|ovary(2)|prostate(6)|skin(4)|upper_aerodigestive_tract(3)	60			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGACGCGGGCGTGCCGCCTCT	0.701000													47	127					5.13769e-22	7.67539e-22	1	1	0
LRRIQ3	127255	broad.mit.edu	37	1	74575206	74575206	+	Nonsense_Mutation	SNP	C	C	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr1:74575206C>A	ENST00000354431.4	-	5	930	c.739G>T	c.(739-741)Gaa>Taa	p.E247*	LRRIQ3_ENST00000370909.2_Nonsense_Mutation_p.E139*|LRRIQ3_ENST00000395089.1_Nonsense_Mutation_p.E247*|LRRIQ3_ENST00000468759.1_5'UTR	NM_001105659.1	NP_001099129.1	A6PVS8	LRIQ3_HUMAN	leucine-rich repeats and IQ motif containing 3	247				QQEKII -> TAGKNY (in Ref. 1; BAD18621).						NS(2)|breast(1)|central_nervous_system(2)|endometrium(7)|kidney(5)|large_intestine(13)|liver(1)|lung(27)|ovary(3)|prostate(1)|skin(5)|soft_tissue(1)|upper_aerodigestive_tract(5)	73						ATAATTTTTTCCTGCTGTTTT	0.313000													6	60					0.00116845	0.00124685	1	1	0
CLDN25	644672	broad.mit.edu	37	11	113650517	113650517	+	Translation_Start_Site	SNP	T	T	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr11:113650517T>A	ENST00000453129.2	+	0	49					NM_001101389.1	NP_001094859.1	C9JDP6	CLD25_HUMAN	claudin 25							integral to membrane|tight junction	structural molecule activity			large_intestine(1)|lung(6)|ovary(1)|urinary_tract(2)	10						TGGGAGTGACTATGGCCTGGA	0.547000													19	81					0	0	1	0	0
IGSF3	3321	broad.mit.edu	37	1	117142905	117142905	+	Missense_Mutation	SNP	C	C	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr1:117142905C>A	ENST00000369486.3	-	7	2452	c.1687G>T	c.(1687-1689)Gac>Tac	p.D563Y	IGSF3_ENST00000318837.6_Missense_Mutation_p.D583Y|IGSF3_ENST00000369483.1_Missense_Mutation_p.D583Y	NM_001007237.1	NP_001007238.1	O75054	IGSF3_HUMAN	immunoglobulin superfamily, member 3	563	Ig-like C2-type 5.					integral to membrane				NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|liver(1)|lung(31)|ovary(4)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)	62	Lung SC(450;0.225)	all_cancers(81;1.24e-06)|all_epithelial(167;4.85e-07)|all_lung(203;1.66e-06)|Lung NSC(69;1.11e-05)		Lung(183;0.0142)|Colorectal(144;0.0929)|LUSC - Lung squamous cell carcinoma(189;0.108)|COAD - Colon adenocarcinoma(174;0.139)|all cancers(265;0.159)|Epithelial(280;0.166)		CACTGCAAGTCAAAGGAGTCG	0.582000													4	36					0.150653	0.151731	1	1	0
PCDH11X	27328	broad.mit.edu	37	X	91873901	91873901	+	Nonsense_Mutation	SNP	A	A	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chrX:91873901A>T	ENST00000373094.1	+	7	4851	c.4006A>T	c.(4006-4008)Aga>Tga	p.R1336*	PCDH11X_ENST00000373088.1_Nonsense_Mutation_p.R1299*|PCDH11X_ENST00000298274.8_Nonsense_Mutation_p.R1299*|PCDH11X_ENST00000504220.1_3'UTR|PCDH11X_ENST00000406881.1_Nonsense_Mutation_p.R1328*|PCDH11X_ENST00000373097.1_Nonsense_Mutation_p.R1326*|PCDH11X_ENST00000361655.2_Nonsense_Mutation_p.R1318*	NM_032968.3	NP_116750.1	Q9BZA7	PC11X_HUMAN	protocadherin 11 X-linked	1336					homophilic cell adhesion	integral to plasma membrane	calcium ion binding			NS(1)|autonomic_ganglia(1)|biliary_tract(1)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(30)|liver(4)|lung(92)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	159						CAGACCGTCCAGAGGTGATTC	0.373000													66	60					0	0	1	0	0
CIRBP	1153	broad.mit.edu	37	19	1272009	1272009	+	Missense_Mutation	SNP	G	G	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr19:1272009G>A	ENST00000444172.2	+	5	436	c.302G>A	c.(301-303)cGg>cAg	p.R101Q	CIRBP_ENST00000586472.1_Missense_Mutation_p.R154Q|CIRBP_ENST00000588230.1_Missense_Mutation_p.R154Q|CIRBP_ENST00000413636.2_Missense_Mutation_p.R120Q|CIRBP_ENST00000589686.1_Missense_Mutation_p.R154Q|CIRBP_ENST00000320936.5_Missense_Mutation_p.R154Q|CIRBP_ENST00000589710.1_Missense_Mutation_p.R154Q|CIRBP_ENST00000588030.1_Missense_Mutation_p.R154Q|CIRBP_ENST00000591935.1_Missense_Mutation_p.R154Q|CIRBP_ENST00000587323.1_Missense_Mutation_p.R154Q|CIRBP_ENST00000589235.1_Missense_Mutation_p.R154Q|CIRBP_ENST00000585630.1_Missense_Mutation_p.R154Q|CIRBP_ENST00000586773.1_Missense_Mutation_p.R154Q|CIRBP_ENST00000588090.1_Missense_Mutation_p.R154Q|CIRBP_ENST00000587896.1_Missense_Mutation_p.R154Q|CIRBP_ENST00000589660.1_Missense_Mutation_p.R154Q			Q14011	CIRBP_HUMAN	cold inducible RNA binding protein	154	Gly-rich.				mRNA stabilization|positive regulation of translation|response to cold|response to UV|stress granule assembly	nucleoplasm|stress granule	mRNA 3'-UTR binding|nucleotide binding|protein binding|SSU rRNA binding|translation repressor activity			endometrium(1)|large_intestine(1)|lung(3)	5		Acute lymphoblastic leukemia(61;4.36e-14)|all_hematologic(61;4.84e-09)|Lung NSC(49;0.000332)|all_lung(49;0.000498)|Breast(49;0.0014)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TACAGTGACCGGAGCTCGGGC	0.602000													15	76					0	0	1	0	0
MAGEL2	54551	broad.mit.edu	37	15	23889981	23889981	+	Missense_Mutation	SNP	C	C	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr15:23889981C>A	ENST00000532292.1	-	1	1194	c.1100G>T	c.(1099-1101)tGg>tTg	p.W367L		NM_019066.4	NP_061939.3			MAGE-like 2											breast(1)|endometrium(1)|large_intestine(2)|lung(2)|upper_aerodigestive_tract(1)	7		all_cancers(20;1.78e-24)|all_epithelial(15;7.75e-22)|Lung NSC(15;2.96e-18)|all_lung(15;2.8e-17)|Breast(32;0.000625)|Colorectal(260;0.14)		all cancers(64;1.84e-06)|Epithelial(43;1.2e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00177)		CGGGCCCTCCCAGGCACTCAG	0.667000													7	37					0.000157383	0.000172422	1	1	0
GGH	8836	broad.mit.edu	37	8	63938819	63938819	+	Missense_Mutation	SNP	T	T	C			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr8:63938819T>C	ENST00000260118.6	-	5	799	c.397A>G	c.(397-399)Aca>Gca	p.T133A	GGH_ENST00000518113.1_5'UTR	NM_003878.2	NP_003869.1	Q92820	GGH_HUMAN	gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)	133	Gamma-glutamyl hydrolase.				glutamine metabolic process	extracellular space|lysosome|melanosome	gamma-glutamyl-peptidase activity			breast(1)|kidney(1)|large_intestine(1)|liver(1)|lung(6)|stomach(1)	11	Breast(64;0.0716)	all_cancers(86;0.189)|Lung NSC(129;0.0324)|all_lung(136;0.0593)|all_epithelial(80;0.131)			Folic Acid(DB00158)|L-Glutamic Acid(DB00142)	CCAAGGCATGTGCCCCACACA	0.393000													24	40					0	0	1	0	0
PGAP1	80055	broad.mit.edu	37	2	197711726	197711726	+	Splice_Site	SNP	C	C	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr2:197711726C>A	ENST00000354764.3	-	22	2265		c.e22+1			NM_024989.3	NP_079265.2	Q75T13	PGAP1_HUMAN	post-GPI attachment to proteins 1						attachment of GPI anchor to protein|C-terminal protein lipidation|intracellular protein transport|myo-inositol transport	integral to membrane|intrinsic to endoplasmic reticulum membrane	nuclease activity|phosphoric ester hydrolase activity			breast(4)|central_nervous_system(2)|endometrium(4)|kidney(2)|large_intestine(9)|lung(11)|ovary(6)|stomach(1)|urinary_tract(1)	40						TCATTCTTTACCTTTTCAAAG	0.328000													12	48					2.80697e-09	3.60844e-09	1	1	0
TKTL2	84076	broad.mit.edu	37	4	164393184	164393184	+	Missense_Mutation	SNP	C	C	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr4:164393184C>T	ENST00000280605.3	-	1	1863	c.1703G>A	c.(1702-1704)aGg>aAg	p.R568K		NM_032136.4	NP_115512.3	Q9H0I9	TKTL2_HUMAN	transketolase-like 2	568						cytoplasm	metal ion binding|transketolase activity			breast(1)|endometrium(4)|kidney(2)|large_intestine(9)|lung(42)|ovary(3)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)	70	all_hematologic(180;0.166)	Prostate(90;0.0959)|all_neural(102;0.223)				GCCACCTTCCCTGTAGTGATC	0.532000													16	139					0	0	1	0	0
GRPR	2925	broad.mit.edu	37	X	16142296	16142296	+	Missense_Mutation	SNP	G	G	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chrX:16142296G>A	ENST00000380289.2	+	1	618	c.220G>A	c.(220-222)Gtt>Att	p.V74I		NM_005314.2	NP_005305.1	P30550	GRPR_HUMAN	gastrin-releasing peptide receptor	74					cell proliferation	integral to plasma membrane	bombesin receptor activity			central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(12)|ovary(3)|stomach(1)|upper_aerodigestive_tract(3)	25	Hepatocellular(33;0.183)					CATGCGAAACGTTCCAAACCT	0.483000											OREG0019682	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	27	59					0	0	1	0	0
MDM1	56890	broad.mit.edu	37	12	68708778	68708778	+	Silent	SNP	T	T	C			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr12:68708778T>C	ENST00000303145.7	-	9	1535	c.1449A>G	c.(1447-1449)caA>caG	p.Q483Q	MDM1_ENST00000540418.1_Silent_p.Q203Q|MDM1_ENST00000411698.2_Silent_p.Q448Q	NM_017440.4	NP_059136.2	Q8TC05	MDM1_HUMAN	Mdm1 nuclear protein homolog (mouse)	483						nucleus				breast(1)|endometrium(4)|kidney(1)|large_intestine(4)|lung(10)|ovary(3)|pancreas(1)|prostate(2)|skin(7)	33			Lung(24;0.000131)|LUAD - Lung adenocarcinoma(15;0.00107)|STAD - Stomach adenocarcinoma(21;0.018)	GBM - Glioblastoma multiforme(7;0.000174)		CCAACTTCTCTTGCTCTCCCA	0.448000													102	252					0	0	1	0	0
TREML3P	340206	broad.mit.edu	37	6	41185530	41185530	+	RNA	SNP	C	C	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr6:41185530C>A	ENST00000564680.1	-	0	155																											TTGGCTTGTCCCAGATTGTGT	0.473000													9	29					2.17888e-05	2.47794e-05	1	1	0
NAV2	89797	broad.mit.edu	37	11	20071402	20071402	+	Missense_Mutation	SNP	C	C	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr11:20071402C>A	ENST00000396085.1	+	16	4752	c.4391C>A	c.(4390-4392)gCt>gAt	p.A1464D	NAV2_ENST00000360655.4_Missense_Mutation_p.A1400D|NAV2_ENST00000311043.8_Intron|NAV2_ENST00000540292.1_Missense_Mutation_p.A1418D|NAV2_ENST00000533917.1_Intron|NAV2_ENST00000349880.4_Missense_Mutation_p.A1464D|NAV2_ENST00000527559.2_Missense_Mutation_p.A1416D|NAV2_ENST00000396087.3_Missense_Mutation_p.A1487D	NM_182964.5	NP_892009.3	Q8IVL1	NAV2_HUMAN	neuron navigator 2	1487	Ser-rich.					nucleus	ATP binding|helicase activity			NS(1)|breast(2)|central_nervous_system(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(26)|lung(38)|ovary(3)|pancreas(1)|prostate(7)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	116						TCCCCTGCTGCTAGCCCTAAG	0.493000													19	96					8.10497e-08	1.0027e-07	1	1	0
CENPA	1058	broad.mit.edu	37	2	27015104	27015104	+	Missense_Mutation	SNP	G	G	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr2:27015104G>T	ENST00000335756.4	+	2	406	c.206G>T	c.(205-207)cGc>cTc	p.R69L	CENPA_ENST00000475662.1_3'UTR|CENPA_ENST00000233505.8_Missense_Mutation_p.R69L	NM_001809.3	NP_001800.1	P49450	CENPA_HUMAN	centromere protein A	69	H3-like.				CenH3-containing nucleosome assembly at centromere|establishment of mitotic spindle orientation|interspecies interaction between organisms|kinetochore assembly|mitotic prometaphase|protein localization to chromosome, centromeric region	condensed nuclear chromosome kinetochore|cytosol|nucleoplasm|nucleosome	chromatin binding|DNA binding|protein binding			endometrium(1)|large_intestine(3)|lung(3)|urinary_tract(1)	8	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CCCTTCAGCCGCCTGGTAAGC	0.517000													9	13					1.12685e-05	1.29496e-05	1	1	0
POLL	27343	broad.mit.edu	37	10	103347097	103347097	+	Missense_Mutation	SNP	C	C	G	rs139055788		TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr10:103347097C>G	ENST00000370162.3	-	2	515	c.21G>C	c.(19-21)ttG>ttC	p.L7F	POLL_ENST00000370158.3_5'UTR|DPCD_ENST00000416979.2_5'UTR|POLL_ENST00000436284.2_Intron|POLL_ENST00000456836.2_5'UTR|POLL_ENST00000370169.1_Missense_Mutation_p.L7F|POLL_ENST00000299206.4_Missense_Mutation_p.L7F|POLL_ENST00000339310.3_5'UTR|POLL_ENST00000370172.1_Intron|DPCD_ENST00000470165.1_3'UTR	NM_001174084.1|NM_001174085.1|NM_013274.3	NP_001167555.1|NP_001167556.1|NP_037406.1	Q9UGP5	DPOLL_HUMAN	polymerase (DNA directed), lambda	7					DNA replication|nucleotide-excision repair|somatic hypermutation of immunoglobulin genes	nucleus	DNA binding|DNA-directed DNA polymerase activity|lyase activity|metal ion binding			biliary_tract(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(2)|lung(7)|upper_aerodigestive_tract(2)	19		Colorectal(252;0.234)		Epithelial(162;1.55e-08)|all cancers(201;6.64e-07)		GAAATGCCTTCAAGATACCCC	0.507000								DNA polymerases (catalytic subunits)					17	104					0	0	1	0	0
EFCAB13	124989	broad.mit.edu	37	17	45452284	45452284	+	Missense_Mutation	SNP	C	C	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr17:45452284C>T	ENST00000331493.2	+	12	1735	c.1324C>T	c.(1324-1326)Ctc>Ttc	p.L442F	EFCAB13_ENST00000517484.1_Missense_Mutation_p.L346F	NM_152347.4	NP_689560.3			EF-hand calcium binding domain 13																		GCATTCCAGTCTCCAAAAACA	0.383000													7	52					0	0	1	0	0
CMYA5	202333	broad.mit.edu	37	5	79030449	79030449	+	Missense_Mutation	SNP	C	C	G			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr5:79030449C>G	ENST00000446378.2	+	2	5892	c.5861C>G	c.(5860-5862)tCt>tGt	p.S1954C		NM_153610.3	NP_705838.3	Q8N3K9	CMYA5_HUMAN	cardiomyopathy associated 5	1954						perinuclear region of cytoplasm				NS(2)|breast(4)|central_nervous_system(1)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(4)|large_intestine(37)|lung(34)|ovary(6)|pancreas(2)|prostate(5)|skin(5)|stomach(11)|upper_aerodigestive_tract(3)|urinary_tract(1)	128		Lung NSC(167;0.00296)|all_lung(232;0.00327)|Ovarian(174;0.0262)		OV - Ovarian serous cystadenocarcinoma(54;9.85e-46)|Epithelial(54;3.38e-40)|all cancers(79;3.43e-35)		GCTGAAGAATCTCATTTGTCA	0.453000													6	32					0	0	1	0	0
PIK3R4	30849	broad.mit.edu	37	3	130400415	130400415	+	Missense_Mutation	SNP	C	C	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr3:130400415C>A	ENST00000356763.3	-	17	4185	c.3628G>T	c.(3628-3630)Gtg>Ttg	p.V1210L	PIK3R4_ENST00000512677.1_5'UTR	NM_014602.2	NP_055417.1	Q99570	PI3R4_HUMAN	phosphoinositide-3-kinase, regulatory subunit 4	1210					fibroblast growth factor receptor signaling pathway|innate immune response|insulin receptor signaling pathway	cytosol	ATP binding|protein binding|protein serine/threonine kinase activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(6)|kidney(6)|large_intestine(16)|lung(28)|ovary(6)|pancreas(1)|prostate(2)|skin(5)|stomach(1)|urinary_tract(1)	77						CACATGGACACTTCGTTGTTG	0.433000													17	65					5.3912e-06	6.2538e-06	1	1	0
CWH43	80157	broad.mit.edu	37	4	48996698	48996698	+	Nonsense_Mutation	SNP	A	A	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr4:48996698A>T	ENST00000226432.4	+	5	757	c.574A>T	c.(574-576)Aga>Tga	p.R192*	CWH43_ENST00000513409.1_Nonsense_Mutation_p.R165*	NM_025087.2	NP_079363.2	Q9H720	PG2IP_HUMAN	cell wall biogenesis 43 C-terminal homolog (S. cerevisiae)	192					GPI anchor biosynthetic process	integral to membrane				cervix(1)|endometrium(4)|kidney(1)|large_intestine(4)|lung(26)|ovary(1)|prostate(1)|skin(4)|urinary_tract(1)	43						GATGGCCTCTAGACCCAACTG	0.468000													14	113					0	0	1	0	0
EFS	10278	broad.mit.edu	37	14	23828664	23828664	+	Silent	SNP	T	T	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr14:23828664T>A	ENST00000216733.3	-	4	1630	c.1023A>T	c.(1021-1023)ccA>ccT	p.P341P	EFS_ENST00000351354.3_Silent_p.P248P|EFS_ENST00000429593.2_Silent_p.P172P	NM_005864.2	NP_005855.1	O43281	EFS_HUMAN	embryonal Fyn-associated substrate	341	Pro-rich.				cell adhesion|intracellular signal transduction	cytoplasm	SH3 domain binding			endometrium(2)|kidney(1)|large_intestine(1)|liver(1)|lung(5)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(2)	16	all_cancers(95;7.12e-06)			GBM - Glioblastoma multiforme(265;0.00649)		GCAGGCGGGGTGGGGGTGGGG	0.697000													18	76					0	0	1	0	0
TAS1R2	80834	broad.mit.edu	37	1	19184026	19184026	+	Silent	SNP	C	C	G			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr1:19184026C>G	ENST00000375371.3	-	2	303	c.282G>C	c.(280-282)ctG>ctC	p.L94L	RP13-279N23.2_ENST00000494072.3_3'UTR	NM_152232.2	NP_689418.2	Q8TE23	TS1R2_HUMAN	taste receptor, type 1, member 2	94					detection of chemical stimulus involved in sensory perception of sweet taste	plasma membrane	protein heterodimerization activity|taste receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(4)|large_intestine(10)|lung(14)|ovary(1)|pancreas(3)|prostate(1)|skin(3)|stomach(1)	45		Colorectal(325;3.46e-05)|all_lung(284;0.000321)|Lung NSC(340;0.000398)|Renal(390;0.000518)|Breast(348;0.000812)|Ovarian(437;0.00764)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00466)|BRCA - Breast invasive adenocarcinoma(304;3.56e-05)|Kidney(64;0.000177)|KIRC - Kidney renal clear cell carcinoma(64;0.00262)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)	Aspartame(DB00168)	TCTCATAGCCCAGCAGCACAC	0.547000													12	67					0	0	1	0	0
P2RY10	27334	broad.mit.edu	37	X	78217036	78217036	+	Nonstop_Mutation	SNP	A	A	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chrX:78217036A>T	ENST00000171757.2	+	4	1299	c.1019A>T	c.(1018-1020)tAa>tTa	p.*340L	P2RY10_ENST00000544091.1_Nonstop_Mutation_p.*340L	NM_014499.2	NP_055314.1	O00398	P2Y10_HUMAN	purinergic receptor P2Y, G-protein coupled, 10	0						integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			breast(2)|central_nervous_system(1)|endometrium(3)|large_intestine(9)|lung(22)|ovary(3)|skin(2)	42						ATGATTGGCTAAAATTAAGAT	0.413000													44	41					0	0	1	0	0
NAV3	89795	broad.mit.edu	37	12	78569132	78569132	+	Missense_Mutation	SNP	C	C	G			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr12:78569132C>G	ENST00000397909.2	+	25	5201	c.5028C>G	c.(5026-5028)atC>atG	p.I1676M	NAV3_ENST00000266692.7_Missense_Mutation_p.I1499M|NAV3_ENST00000536525.2_Missense_Mutation_p.I1676M|NAV3_ENST00000228327.6_Missense_Mutation_p.I1676M			Q8IVL0	NAV3_HUMAN	neuron navigator 3	1676						nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			NS(2)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(13)|kidney(16)|large_intestine(39)|liver(2)|lung(126)|ovary(5)|pancreas(3)|prostate(6)|skin(5)|stomach(2)|upper_aerodigestive_tract(8)|urinary_tract(1)	236						TTTCTAGTATCAACAGTGCCA	0.423000										HNSCC(70;0.22)			6	33					0	0	1	0	0
TUBB8	347688	broad.mit.edu	37	10	93378	93378	+	Missense_Mutation	SNP	C	C	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr10:93378C>A	ENST00000447903.2	-	4	1053	c.738G>T	c.(736-738)agG>agT	p.R246S	TUBB8_ENST00000309812.4_Missense_Mutation_p.R318S			Q3ZCM7	TBB8_HUMAN	tubulin, beta 8 class VIII	318					microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|structural molecule activity			NS(1)|cervix(1)|endometrium(4)|large_intestine(5)|lung(12)|ovary(2)|prostate(3)|skin(3)|stomach(1)	32		all_cancers(4;0.00131)|all_lung(4;0.000777)|Lung NSC(4;0.0043)|all_epithelial(10;0.0154)|Colorectal(49;0.235)		Epithelial(11;0.00341)|all cancers(11;0.00922)|OV - Ovarian serous cystadenocarcinoma(14;0.0508)|Lung(33;0.132)		GCATGCGACCCCTGAAAATGG	0.517000													30	145					3.80469e-20	5.64125e-20	1	1	0
MUC2	4583	broad.mit.edu	37	11	1093935	1093935	+	Splice_Site	SNP	T	T	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr11:1093935T>A	ENST00000441003.2	+	30	5779		c.e30+2		MUC2_ENST00000361558.6_Intron|MUC2_ENST00000333592.6_Splice_Site	NM_002457.2	NP_002448.2	Q02817	MUC2_HUMAN	mucin 2, oligomeric mucus/gel-forming							inner mucus layer|outer mucus layer	protein binding			NS(3)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(26)|haematopoietic_and_lymphoid_tissue(4)|kidney(11)|large_intestine(5)|lung(22)|ovary(2)|prostate(16)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	102		all_cancers(49;1.08e-07)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.191)		BRCA - Breast invasive adenocarcinoma(625;0.000207)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)	Pranlukast(DB01411)	CCCCTCCAGGTAAGCAGAGCT	0.667000													8	43					0	0	1	0	0
OR1A1	8383	broad.mit.edu	37	17	3119074	3119074	+	Missense_Mutation	SNP	C	C	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr17:3119074C>A	ENST00000304094.1	+	1	160	c.160C>A	c.(160-162)Cgc>Agc	p.R54S		NM_014565.2	NP_055380.2	Q9P1Q5	OR1A1_HUMAN	olfactory receptor, family 1, subfamily A, member 1	54					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.R54C(1)		NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(7)|ovary(1)|pancreas(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	23						CTCTGATGTTCGCCTTCACAA	0.458000													43	142					7.88023e-25	1.18444e-24	1	1	0
HERPUD2	64224	broad.mit.edu	37	7	35733845	35733845	+	Missense_Mutation	SNP	C	C	G			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr7:35733845C>G	ENST00000396081.1	-	1	900	c.96G>C	c.(94-96)tgG>tgC	p.W32C	HERPUD2_ENST00000311350.3_Missense_Mutation_p.W32C	NM_022373.4	NP_071768.3	Q9BSE4	HERP2_HUMAN	HERPUD family member 2	32	Ubiquitin-like.				response to unfolded protein	integral to membrane				kidney(3)|large_intestine(5)|lung(6)|ovary(3)|prostate(1)	18						TCCCCACGGTCCAGTTCAAGA	0.473000													30	147					0	0	1	0	0
IGHV1OR21-1	390530	broad.mit.edu	37	21	10862892	10862892	+	RNA	SNP	G	G	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr21:10862892G>T	ENST00000559480.1	+	0	188																				breast(1)|endometrium(1)|kidney(3)|lung(20)|urinary_tract(1)	26						CATGCACAAGGGCTTGAGTGG	0.552000													20	150					8.34094e-07	9.90863e-07	1	1	0
SMARCA4	6597	broad.mit.edu	37	19	11123789	11123789	+	Splice_Site	SNP	G	G	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr19:11123789G>T	ENST00000358026.2	+	16	2722		c.e16+1		SMARCA4_ENST00000590574.1_Splice_Site|SMARCA4_ENST00000589677.1_Splice_Site|SMARCA4_ENST00000541122.2_Splice_Site|SMARCA4_ENST00000450717.3_Splice_Site|SMARCA4_ENST00000344626.4_Splice_Site|SMARCA4_ENST00000413806.3_Splice_Site|CTC-215O4.4_ENST00000587831.1_RNA|SMARCA4_ENST00000444061.3_Splice_Site|SMARCA4_ENST00000429416.3_Splice_Site	NM_001128849.1	NP_001122321.1	P51532	SMCA4_HUMAN	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4						chromatin remodeling|negative regulation of androgen receptor signaling pathway|negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|negative regulation of transcription from RNA polymerase II promoter|nervous system development|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nBAF complex|npBAF complex|nuclear chromatin|SWI/SNF complex|WINAC complex	androgen receptor binding|ATP binding|DNA binding|DNA-dependent ATPase activity|helicase activity|histone acetyl-lysine binding|identical protein binding|p53 binding|protein N-terminus binding|transcription corepressor activity	p.?(1)		adrenal_gland(1)|autonomic_ganglia(1)|breast(6)|central_nervous_system(23)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(16)|liver(4)|lung(60)|ovary(10)|pancreas(7)|prostate(3)|skin(8)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	163		all_lung(6;0.0512)|Lung NSC(9;0.0568)				TGCCTCTCTCGTGAGTACCCG	0.552000			"""F, N, Mis"""		NSCLC								19	34					4.35082e-09	5.57131e-09	1	1	0
SDCCAG8	10806	broad.mit.edu	37	1	243652396	243652396	+	Missense_Mutation	SNP	T	T	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr1:243652396T>A	ENST00000366541.3	+	17	2184	c.2066T>A	c.(2065-2067)cTg>cAg	p.L689Q	SDCCAG8_ENST00000343783.6_Missense_Mutation_p.L544Q|SDCCAG8_ENST00000355875.4_Missense_Mutation_p.L646Q|AKT3_ENST00000336199.5_Intron	NM_006642.3	NP_006633.1	Q86SQ7	SDCG8_HUMAN	serologically defined colon cancer antigen 8	689	Gln-rich.|Mediates interaction with OFD1.|Sufficient for homodimerization (By similarity).				establishment of cell polarity|G2/M transition of mitotic cell cycle|tube formation	cell-cell junction|centriole|cytosol	protein binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(17)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29	all_cancers(71;0.000545)|all_epithelial(71;0.000509)|all_lung(81;0.0821)|Ovarian(71;0.0919)|all_neural(11;0.101)|Breast(184;0.218)	all_cancers(173;0.00395)	all cancers(7;1.58e-07)|GBM - Glioblastoma multiforme(7;5.12e-06)|OV - Ovarian serous cystadenocarcinoma(106;0.00392)	COAD - Colon adenocarcinoma(196;0.145)		CAGCTTCTCCTGGAGAGGCAG	0.632000													5	35					0	0	1	0	0
DAG1	1605	broad.mit.edu	37	3	49569741	49569741	+	Silent	SNP	C	C	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr3:49569741C>T	ENST00000545947.1	+	6	2519	c.1797C>T	c.(1795-1797)ccC>ccT	p.P599P	DAG1_ENST00000515359.2_Silent_p.P599P|DAG1_ENST00000308775.2_Silent_p.P599P|DAG1_ENST00000541308.1_Silent_p.P599P|DAG1_ENST00000539901.1_Silent_p.P599P|DAG1_ENST00000538711.1_Silent_p.P599P	NM_001177634.2	NP_001171105.1	Q14118	DAG1_HUMAN	dystroglycan 1 (dystrophin-associated glycoprotein 1)	599	Peptidase S72.				cytoskeletal anchoring at plasma membrane|interspecies interaction between organisms|microtubule anchoring|negative regulation of cell migration|negative regulation of MAPKKK cascade|negative regulation of protein kinase B signaling cascade	basement membrane|contractile ring|cytoplasm|cytoskeleton|dystrophin-associated glycoprotein complex|extracellular space|filopodium|integral to membrane|integral to membrane of membrane fraction|lamellipodium|nucleoplasm	actin binding|alpha-actinin binding|calcium ion binding|laminin-1 binding|receptor activity|structural constituent of muscle|tubulin binding|vinculin binding			NS(1)|autonomic_ganglia(2)|breast(2)|endometrium(1)|large_intestine(8)|lung(5)|ovary(2)|prostate(1)|skin(1)	23				BRCA - Breast invasive adenocarcinoma(193;5.13e-05)|Kidney(197;0.00241)|KIRC - Kidney renal clear cell carcinoma(197;0.00258)		ACAGGCGCCCCCAAGGGGATA	0.562000													11	72					0	0	1	0	0
ZC3H3	23144	broad.mit.edu	37	8	144620208	144620208	+	Silent	SNP	G	G	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr8:144620208G>A	ENST00000262577.5	-	2	1360	c.1329C>T	c.(1327-1329)agC>agT	p.S443S		NM_015117.2	NP_055932.2	Q8IXZ2	ZC3H3_HUMAN	zinc finger CCCH-type containing 3	443					mRNA polyadenylation|poly(A)+ mRNA export from nucleus|regulation of mRNA export from nucleus	nucleus	nucleic acid binding|zinc ion binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(1)|lung(13)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	23	all_cancers(97;8.64e-11)|all_epithelial(106;6.43e-09)|Lung NSC(106;0.000202)|all_lung(105;0.000548)|Ovarian(258;0.0212)|Acute lymphoblastic leukemia(118;0.155)		Colorectal(110;0.107)|BRCA - Breast invasive adenocarcinoma(115;0.107)			TCTTGGTGCGGCTCTTCACTT	0.627000													11	58					0	0	1	0	0
ANKRD20A8P	729171	broad.mit.edu	37	2	95522786	95522786	+	RNA	SNP	T	T	C			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr2:95522786T>C	ENST00000432432.2	-	0	241					NR_040113.1													p.K44K(1)									CGGCGTCGCCTTTGACAGCTG	0.687000													7	97					0	0	1	0	0
ZMAT3	64393	broad.mit.edu	37	3	178748673	178748673	+	Missense_Mutation	SNP	G	G	C			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr3:178748673G>C	ENST00000311417.2	-	3	1126	c.385C>G	c.(385-387)Ccg>Gcg	p.P129A	ZMAT3_ENST00000432729.1_Missense_Mutation_p.P129A	NM_022470.3	NP_071915.1	Q9HA38	ZMAT3_HUMAN	zinc finger, matrin-type 3	129					apoptosis|protein transport|regulation of growth|response to DNA damage stimulus|transmembrane transport	nucleolus	RNA binding|zinc ion binding			breast(1)|endometrium(1)|large_intestine(6)|lung(2)|ovary(2)|prostate(1)|skin(1)	14	all_cancers(143;3.31e-18)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;6.74e-27)|GBM - Glioblastoma multiforme(14;0.00448)|BRCA - Breast invasive adenocarcinoma(182;0.0527)			CTCACCTGCGGAGGGACTGGA	0.468000													20	129					0	0	1	0	0
KCNB2	9312	broad.mit.edu	37	8	73848403	73848403	+	Missense_Mutation	SNP	G	G	C			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr8:73848403G>C	ENST00000523207.1	+	3	1401	c.813G>C	c.(811-813)ttG>ttC	p.L271F		NM_004770.2	NP_004761.2	Q92953	KCNB2_HUMAN	potassium voltage-gated channel, Shab-related subfamily, member 2	271					regulation of smooth muscle contraction	voltage-gated potassium channel complex	delayed rectifier potassium channel activity|protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(20)|liver(2)|lung(31)|ovary(2)|pancreas(3)|prostate(2)|skin(8)|upper_aerodigestive_tract(4)|urinary_tract(1)	85	Breast(64;0.137)		Epithelial(68;0.105)			TCATTGATTTGCTGGCCATCT	0.463000													32	96					0	0	1	0	0
RFX4	5992	broad.mit.edu	37	12	107141292	107141292	+	Missense_Mutation	SNP	C	C	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr12:107141292C>A	ENST00000392842.1	+	16	2125	c.1711C>A	c.(1711-1713)Cag>Aag	p.Q571K	RFX4_ENST00000357881.4_Missense_Mutation_p.Q580K|RFX4_ENST00000229387.5_Missense_Mutation_p.Q477K|RP11-144F15.1_ENST00000551505.1_Intron	NM_213594.2	NP_998759.1	Q33E94	RFX4_HUMAN	regulatory factor X, 4 (influences HLA class II expression)	571					transcription, DNA-dependent	nucleus	DNA binding			NS(2)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(20)|pancreas(1)|upper_aerodigestive_tract(1)	35						GAACTCCCAACAGCTGCCCTG	0.512000													14	77					0.146539	0.14865	1	1	0
GCFC2	6936	broad.mit.edu	37	2	75929319	75929319	+	Missense_Mutation	SNP	C	C	G	rs146928795	by1000genomes	TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr2:75929319C>G	ENST00000470503.1	-	3	668	c.625G>C	c.(625-627)Gat>Cat	p.D209H	GCFC2_ENST00000409857.3_Intron|GCFC2_ENST00000321027.3_Intron|GCFC2_ENST00000541687.1_Intron	NM_001201335.1	NP_001188264.1	P16383	GCF_HUMAN	GC-rich sequence DNA-binding factor 2	623					negative regulation of transcription, DNA-dependent	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity										ATTGGTAAATCCATACTTGAT	0.333000													21	82					0	0	1	0	0
SH2D5	400745	broad.mit.edu	37	1	21052498	21052498	+	Missense_Mutation	SNP	C	C	G			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr1:21052498C>G	ENST00000375031.1	-	4	677	c.53G>C	c.(52-54)tGc>tCc	p.C18S	SH2D5_ENST00000460804.1_Intron|SH2D5_ENST00000444387.2_Missense_Mutation_p.C102S	NM_001103160.1	NP_001096630.1	Q6ZV89	SH2D5_HUMAN	SH2 domain containing 5	18										lung(4)|prostate(1)|upper_aerodigestive_tract(1)	6		Colorectal(325;3.46e-05)|all_lung(284;5.32e-05)|Lung NSC(340;5.51e-05)|Renal(390;9.67e-05)|Breast(348;0.00179)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0181)|COAD - Colon adenocarcinoma(152;1.17e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000142)|GBM - Glioblastoma multiforme(114;0.000465)|Kidney(64;0.000476)|STAD - Stomach adenocarcinoma(196;0.00303)|KIRC - Kidney renal clear cell carcinoma(64;0.00634)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.199)		GGCAAACTGGCAGTCGGCAGG	0.627000													6	23					0	0	1	0	0
C8orf4	56892	broad.mit.edu	37	8	40011157	40011157	+	Missense_Mutation	SNP	G	G	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr8:40011157G>T	ENST00000315792.3	+	1	169	c.106G>T	c.(106-108)Gtg>Ttg	p.V36L		NM_020130.4	NP_064515.1	Q9NR00	CH004_HUMAN	chromosome 8 open reading frame 4	36					apoptosis					breast(1)|large_intestine(1)|ovary(1)	3	Ovarian(28;0.0173)	all_cancers(7;5.34e-21)|all_epithelial(6;1.04e-14)|Lung NSC(58;9.35e-06)|all_lung(54;1.39e-05)|Hepatocellular(245;0.00745)|Breast(189;0.0334)|Colorectal(162;0.0815)|Myeloproliferative disorder(644;0.116)|Esophageal squamous(32;0.141)	LUSC - Lung squamous cell carcinoma(45;0.000149)	KIRC - Kidney renal clear cell carcinoma(67;0.0923)|Kidney(114;0.111)		TAAGAAAGCCGTGGGCAACAT	0.498000													15	53					1.15088e-07	1.40965e-07	1	1	0
NPHP1	4867	broad.mit.edu	37	2	110922275	110922275	+	Missense_Mutation	SNP	G	G	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr2:110922275G>T	ENST00000316534.4	-	8	834	c.761C>A	c.(760-762)gCg>gAg	p.A254E	NPHP1_ENST00000393272.3_Missense_Mutation_p.A254E|NPHP1_ENST00000417665.1_Missense_Mutation_p.A254E|NPHP1_ENST00000355301.4_Missense_Mutation_p.A192E|NPHP1_ENST00000445609.2_Missense_Mutation_p.A254E			O15259	NPHP1_HUMAN	nephronophthisis 1 (juvenile)	254					actin cytoskeleton organization|cell projection organization|cell-cell adhesion|excretion|retina development in camera-type eye|signal transduction|spermatid differentiation|visual behavior	adherens junction|cell-cell junction|cilium axoneme|cytoplasm|cytoskeleton|motile cilium|photoreceptor connecting cilium	protein binding|structural molecule activity			autonomic_ganglia(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|lung(10)|ovary(2)	24						CTCTGAAATCGCTTTCTGAAC	0.443000													10	92					5.3912e-06	6.2538e-06	1	1	0
NAPRT1	93100	broad.mit.edu	37	8	144657399	144657399	+	Missense_Mutation	SNP	C	C	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr8:144657399C>A	ENST00000449291.2	-	11	1702	c.1408G>T	c.(1408-1410)Gtg>Ttg	p.V470L	NAPRT1_ENST00000460623.1_Splice_Site|NAPRT1_ENST00000426292.3_Splice_Site|NAPRT1_ENST00000276844.7_Missense_Mutation_p.V470L|RP11-661A12.9_ENST00000531730.1_RNA|NAPRT1_ENST00000435154.3_Missense_Mutation_p.V470L			Q6XQN6	PNCB_HUMAN	nicotinate phosphoribosyltransferase domain containing 1	470					nicotinamide metabolic process|nicotinate nucleotide salvage|response to oxidative stress|water-soluble vitamin metabolic process	cytosol|Golgi apparatus|nucleus	nicotinate phosphoribosyltransferase activity|nicotinate-nucleotide diphosphorylase (carboxylating) activity			endometrium(1)|lung(2)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	6	all_cancers(97;6.49e-11)|all_epithelial(106;4.73e-09)|Lung NSC(106;0.000202)|all_lung(105;0.000548)|Ovarian(258;0.014)|Acute lymphoblastic leukemia(118;0.155)		Colorectal(110;0.134)|BRCA - Breast invasive adenocarcinoma(115;0.146)			AGTGGCTCCACCTGGGCTGGC	0.687000													3	20					0.00909568	0.00946027	1	1	0
SULT1C3	442038	broad.mit.edu	37	2	108881408	108881408	+	Missense_Mutation	SNP	C	C	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr2:108881408C>A	ENST00000329106.2	+	6	749	c.749C>A	c.(748-750)aCc>aAc	p.T250N		NM_001008743.1	NP_001008743.1	Q6IMI6	ST1C3_HUMAN	sulfotransferase family, cytosolic, 1C, member 3	250						cytoplasm	alcohol sulfotransferase activity			breast(1)|kidney(1)|large_intestine(1)|lung(8)|prostate(1)|skin(4)	16						ACCAACTATACCACTTTGCCC	0.403000													24	68					9.57634e-11	1.27254e-10	1	1	0
BBS12	166379	broad.mit.edu	37	4	123663171	123663171	+	Nonsense_Mutation	SNP	G	G	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr4:123663171G>T	ENST00000542236.1	+	3	505	c.124G>T	c.(124-126)Gaa>Taa	p.E42*	BBS12_ENST00000314218.3_Nonsense_Mutation_p.E42*	NM_001178007.1	NP_001171478.1	Q6ZW61	BBS12_HUMAN	Bardet-Biedl syndrome 12	42					cellular protein metabolic process	cilium	ATP binding			cervix(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(6)|ovary(2)|prostate(4)	21						TATTATAGATGAAGAATGTCA	0.368000									Bardet-Biedl syndrome				12	52					4.3838e-07	5.26483e-07	1	1	0
TTN	7273	broad.mit.edu	37	2	179616576	179616576	+	Missense_Mutation	SNP	C	C	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr2:179616576C>A	ENST00000360870.5	-	46	10773	c.10551G>T	c.(10549-10551)gaG>gaT	p.E3517D	TTN_ENST00000342175.6_Intron|TTN_ENST00000359218.5_Intron|TTN-AS1_ENST00000578746.1_RNA|TTN_ENST00000591111.1_Intron|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000590773.1_RNA|TTN_ENST00000342992.6_Intron|TTN_ENST00000460472.2_Intron|TTN_ENST00000589042.1_Intron	NM_133379.3	NP_596870.2	Q8WZ42	TITIN_HUMAN	titin	3516	Ig-like 21.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CCGGTTCACCCTCTAAAACAT	0.388000													11	92					0.00829132	0.00866021	1	1	0
SYT10	341359	broad.mit.edu	37	12	33535308	33535308	+	Missense_Mutation	SNP	G	G	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr12:33535308G>T	ENST00000228567.3	-	5	1642	c.1346C>A	c.(1345-1347)tCc>tAc	p.S449Y	SYT10_ENST00000535526.1_Missense_Mutation_p.S268Y	NM_198992.3	NP_945343.1	Q6XYQ8	SYT10_HUMAN	synaptotagmin X	449	C2 2.					cell junction|integral to membrane|synaptic vesicle membrane	metal ion binding|transporter activity			NS(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|liver(1)|lung(18)|ovary(1)|prostate(3)|skin(4)|urinary_tract(1)	42	Lung NSC(5;8.37e-07)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0334)					GACCGCAATGGAGAGGCTGAC	0.453000													6	76					0.00116845	0.00124685	1	1	0
RBBP5	5929	broad.mit.edu	37	1	205090984	205090984	+	Splice_Site	SNP	C	C	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr1:205090984C>A	ENST00000264515.6	-	1	159	c.19_splice	c.e1+1	p.L6_splice	RBBP5_ENST00000367164.1_Splice_Site_p.L6_splice|RBBP5_ENST00000484379.1_5'UTR	NM_001193273.1|NM_005057.3	NP_001180202.1|NP_005048.2	Q15291	RBBP5_HUMAN	retinoblastoma binding protein 5	6					histone H3-K4 methylation|regulation of transcription, DNA-dependent|response to estrogen stimulus|transcription, DNA-dependent	MLL1 complex|Set1C/COMPASS complex	methylated histone residue binding|transcription regulatory region DNA binding			cervix(1)|kidney(3)|large_intestine(4)|lung(14)|ovary(1)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(1)	27	Breast(84;0.0505)		BRCA - Breast invasive adenocarcinoma(75;0.0923)			CCTTCTCACCCAGCAACTCGA	0.607000													12	71					9.05144e-12	1.22424e-11	1	1	0
ZNF831	128611	broad.mit.edu	37	20	57767559	57767559	+	Silent	SNP	C	C	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr20:57767559C>T	ENST00000371030.2	+	1	1485	c.1485C>T	c.(1483-1485)acC>acT	p.T495T		NM_178457.1	NP_848552.1	Q5JPB2	ZN831_HUMAN	zinc finger protein 831	495						intracellular	nucleic acid binding|zinc ion binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(15)|lung(71)|ovary(2)|pancreas(1)|prostate(4)|skin(16)|upper_aerodigestive_tract(2)|urinary_tract(3)	125	all_lung(29;0.0085)					TCTCCACCACCGTGGAATGTG	0.701000													14	55					0	0	1	0	0
OR52A5	390054	broad.mit.edu	37	11	5153674	5153674	+	Missense_Mutation	SNP	T	T	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr11:5153674T>A	ENST00000307388.1	-	1	198	c.199A>T	c.(199-201)Atg>Ttg	p.M67L		NM_001005160.2	NP_001005160.1	Q9H2C5	O52A5_HUMAN	olfactory receptor, family 52, subfamily A, member 5	67					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(8)|lung(18)|skin(3)	35		Medulloblastoma(188;0.0049)|all_neural(188;0.0442)|Breast(177;0.0675)		Epithelial(150;1.74e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)|LUSC - Lung squamous cell carcinoma(625;0.2)		GCTGCCAACATGGCCAAAAAA	0.383000													11	47					0	0	1	0	0
ELOVL4	6785	broad.mit.edu	37	6	80634687	80634687	+	Missense_Mutation	SNP	A	A	T	rs148018494	byFrequency	TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr6:80634687A>T	ENST00000369816.4	-	3	651	c.351T>A	c.(349-351)aaT>aaA	p.N117K		NM_022726.3	NP_073563.1	Q9GZR5	ELOV4_HUMAN	ELOVL fatty acid elongase 4	117					fatty acid elongation, saturated fatty acid|long-chain fatty-acyl-CoA biosynthetic process|triglyceride biosynthetic process|very long-chain fatty acid biosynthetic process	integral to endoplasmic reticulum membrane	G-protein coupled photoreceptor activity|protein binding|transferase activity, transferring acyl groups other than amino-acyl groups			central_nervous_system(2)|cervix(1)|kidney(1)|large_intestine(6)|lung(8)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	22		all_cancers(76;1.83e-05)|Acute lymphoblastic leukemia(125;1.1e-05)|all_hematologic(105;0.00117)|all_epithelial(107;0.011)		BRCA - Breast invasive adenocarcinoma(397;0.0168)	Alpha-Linolenic Acid(DB00132)	CATGAACATTATTAGAATAAT	0.303000													9	64					0	0	1	0	0
ZNF91	7644	broad.mit.edu	37	19	23544859	23544859	+	Missense_Mutation	SNP	T	T	C			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr19:23544859T>C	ENST00000300619.7	-	4	1127	c.922A>G	c.(922-924)Acc>Gcc	p.T308A	ZNF91_ENST00000397082.2_Missense_Mutation_p.T276A|ZNF91_ENST00000599743.1_Intron	NM_003430.2	NP_003421.2	Q05481	ZNF91_HUMAN	zinc finger protein 91	308						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding						all_lung(12;0.0349)|Lung NSC(12;0.0538)|all_epithelial(12;0.0611)				TTAGCAAGGGTTGAAGAATGG	0.393000													7	84					0	0	1	0	0
CA4	762	broad.mit.edu	37	17	58236703	58236703	+	Missense_Mutation	SNP	C	C	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr17:58236703C>A	ENST00000300900.4	+	8	956	c.857C>A	c.(856-858)gCc>gAc	p.A286D		NM_000717.3	NP_000708.1	P22748	CAH4_HUMAN	carbonic anhydrase IV	286					bicarbonate transport|one-carbon metabolic process	anchored to external side of plasma membrane|apical plasma membrane|brush border membrane|ER-Golgi intermediate compartment|membrane fraction|perinuclear region of cytoplasm|rough endoplasmic reticulum|secretory granule membrane|trans-Golgi network|transport vesicle membrane	carbonate dehydratase activity|protein binding|zinc ion binding			kidney(1)|large_intestine(2)|lung(5)|ovary(1)	9	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		Epithelial(12;3.83e-12)|all cancers(12;6.83e-11)		Bendroflumethiazide(DB00436)|Benzthiazide(DB00562)|Chlorothiazide(DB00880)|Cyclothiazide(DB00606)|Diazoxide(DB01119)|Hydrochlorothiazide(DB00999)|Hydroflumethiazide(DB00774)|Methyclothiazide(DB00232)|Quinethazone(DB01325)|Topiramate(DB00273)|Trichlormethiazide(DB01021)	AAGTCCGGGGCCCCGGGTCGG	0.657000													3	19					0.115264	0.117045	1	1	0
OR11H4	390442	broad.mit.edu	37	14	20711258	20711258	+	Nonsense_Mutation	SNP	C	C	G			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr14:20711258C>G	ENST00000315409.2	+	1	361	c.308C>G	c.(307-309)tCa>tGa	p.S103*		NM_001004479.1	NP_001004479.1	Q8NGC9	O11H4_HUMAN	olfactory receptor, family 11, subfamily H, member 4	103					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(3)|lung(11)|ovary(1)|upper_aerodigestive_tract(1)	29	all_cancers(95;0.000888)		Epithelial(56;1.75e-06)|all cancers(55;1.22e-05)	GBM - Glioblastoma multiforme(265;0.0146)		AAGGCCATCTCATTTTCTGGG	0.438000													16	216					0	0	1	0	0
SLC9A7	84679	broad.mit.edu	37	X	46532014	46532014	+	Missense_Mutation	SNP	C	C	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chrX:46532014C>A	ENST00000328306.4	-	4	677	c.652G>T	c.(652-654)Ggg>Tgg	p.G218W		NM_001257291.1|NM_032591.2	NP_001244220.1|NP_115980.1	Q96T83	SL9A7_HUMAN	solute carrier family 9, subfamily A (NHE7, cation proton antiporter 7), member 7	218					regulation of pH	Golgi membrane|integral to membrane|recycling endosome membrane|trans-Golgi network	potassium:hydrogen antiporter activity|protein homodimerization activity|sodium:hydrogen antiporter activity			breast(2)|cervix(2)|endometrium(3)|kidney(1)|large_intestine(6)|lung(3)|ovary(2)|prostate(1)|skin(1)	21						ACAGCAGTCCCCAAGAAGGCA	0.383000													19	31					3.62473e-10	4.74633e-10	1	1	0
FAT4	79633	broad.mit.edu	37	4	126411315	126411315	+	Missense_Mutation	SNP	C	C	G			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr4:126411315C>G	ENST00000394329.3	+	17	13351	c.13338C>G	c.(13336-13338)caC>caG	p.H4446Q	FAT4_ENST00000335110.5_Missense_Mutation_p.H2687Q	NM_024582.4	NP_078858.4	Q6V0I7	FAT4_HUMAN	FAT atypical cadherin 4	4446	EGF-like 6.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						CAGGCCTGCACTCCGGCTTCA	0.612000													19	108					0	0	1	0	0
CSHL1	1444	broad.mit.edu	37	17	61987219	61987219	+	Missense_Mutation	SNP	T	T	C			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr17:61987219T>C	ENST00000259003.10	-	5	479	c.335A>G	c.(334-336)tAc>tGc	p.Y112C	CSHL1_ENST00000346606.6_Missense_Mutation_p.Y80C|CSHL1_ENST00000309894.5_Missense_Mutation_p.Y174C|CSHL1_ENST00000438387.2_Missense_Mutation_p.Y91C|CSHL1_ENST00000561003.1_Silent_p.L175L|CSHL1_ENST00000558099.1_5'UTR|CSHL1_ENST00000450719.3_Silent_p.L164L			Q14406	CSHL_HUMAN	chorionic somatomammotropin hormone-like 1	174						extracellular region	hormone activity|metal ion binding			endometrium(3)|lung(6)	9						AAACTTGCTGTAGGTCTGCTT	0.552000													62	141					0	0	1	0	0
OASL	8638	broad.mit.edu	37	12	121465411	121465411	+	Missense_Mutation	SNP	C	C	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr12:121465411C>A	ENST00000257570.5	-	4	1137	c.867G>T	c.(865-867)gaG>gaT	p.E289D	OASL_ENST00000339275.5_Intron	NM_003733.3	NP_003724.1	Q15646	OASL_HUMAN	2'-5'-oligoadenylate synthetase-like	289					interferon-gamma-mediated signaling pathway|type I interferon-mediated signaling pathway	cytoplasm|nucleolus	ATP binding|DNA binding|double-stranded RNA binding|thyroid hormone receptor binding|transferase activity			NS(1)|endometrium(3)|large_intestine(4)|lung(4)|skin(2)	14	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)					TGACACAATCCTCAATGATTG	0.458000													8	81					4.1943e-16	6.0023e-16	1	1	0
CDHR5	53841	broad.mit.edu	37	11	620375	620375	+	Silent	SNP	G	G	C	rs139559471		TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr11:620375G>C	ENST00000358353.3	-	9	1123	c.801C>G	c.(799-801)ctC>ctG	p.L267L	CDHR5_ENST00000349570.7_Silent_p.L267L|CDHR5_ENST00000397542.2_Silent_p.L267L			Q9HBB8	CDHR5_HUMAN	cadherin-related family member 5	267	Cadherin 3.				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(1)|endometrium(4)|kidney(1)|large_intestine(6)|lung(7)|ovary(1)|skin(2)	23						GACGCAGGACGAGGGGAGATG	0.662000													11	50					0	0	1	0	0
TRPA1	8989	broad.mit.edu	37	8	72935158	72935158	+	Missense_Mutation	SNP	G	G	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr8:72935158G>A	ENST00000262209.4	-	27	3550	c.3343C>T	c.(3343-3345)Cac>Tac	p.H1115Y	RP11-383H13.1_ENST00000524152.1_Intron|RP11-383H13.1_ENST00000457356.4_Intron|RP11-383H13.1_ENST00000537896.1_Intron	NM_007332.2	NP_015628.2	O75762	TRPA1_HUMAN	transient receptor potential cation channel, subfamily A, member 1	1115						integral to plasma membrane				NS(1)|breast(2)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(26)|lung(44)|ovary(4)|prostate(6)|stomach(1)	98			Epithelial(68;0.223)		Menthol(DB00825)	TCAAGATGGTGTGTTTTTGCC	0.423000													11	53					0	0	1	0	0
SLC28A2	9153	broad.mit.edu	37	15	45556216	45556216	+	Missense_Mutation	SNP	G	G	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr15:45556216G>A	ENST00000347644.3	+	6	649	c.584G>A	c.(583-585)aGc>aAc	p.S195N	CTD-2651B20.3_ENST00000561404.1_RNA|CTD-2651B20.3_ENST00000560344.1_RNA	NM_004212.3	NP_004203.2	O43868	S28A2_HUMAN	solute carrier family 28 (concentrative nucleoside transporter), member 2	195					nucleobase, nucleoside and nucleotide metabolic process	integral to plasma membrane|membrane fraction	nucleoside binding|nucleoside:sodium symporter activity|purine nucleoside transmembrane transporter activity			NS(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(12)|ovary(4)|skin(1)	26		all_cancers(109;8.53e-07)|all_epithelial(112;1.39e-05)|Lung NSC(122;8.3e-05)|all_lung(180;0.000547)|Melanoma(134;0.0417)		all cancers(107;3.77e-16)|GBM - Glioblastoma multiforme(94;2.71e-06)		AAACACCACAGCGCAGTGAGT	0.483000													6	60					0	0	1	0	0
ZNF513	130557	broad.mit.edu	37	2	27602975	27602975	+	Missense_Mutation	SNP	C	C	G			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr2:27602975C>G	ENST00000323703.6	-	2	394	c.196G>C	c.(196-198)Gag>Cag	p.E66Q	ZNF513_ENST00000407879.1_Missense_Mutation_p.E4Q	NM_144631.5	NP_653232.3	Q8N8E2	ZN513_HUMAN	zinc finger protein 513	66	Gly-rich.				regulation of transcription, DNA-dependent|response to stimulus|retina development in camera-type eye|transcription, DNA-dependent|visual perception	nucleus	transcription regulatory region DNA binding|zinc ion binding			endometrium(5)|kidney(1)|large_intestine(2)|lung(7)|ovary(2)	17	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GAGTCTCTCTCGAAGCCCATG	0.552000													18	199					0	0	1	0	0
PSTPIP1	9051	broad.mit.edu	37	15	77324705	77324705	+	Missense_Mutation	SNP	C	C	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr15:77324705C>A	ENST00000558012.1	+	11	1297	c.808C>A	c.(808-810)Cag>Aag	p.Q270K	PSTPIP1_ENST00000267939.5_Missense_Mutation_p.Q269K|PSTPIP1_ENST00000379595.3_Missense_Mutation_p.Q270K|PSTPIP1_ENST00000559295.1_Missense_Mutation_p.Q270K|PSTPIP1_ENST00000557995.1_3'UTR	NM_003978.3	NP_003969.2	O43586	PPIP1_HUMAN	proline-serine-threonine phosphatase interacting protein 1	270					cell adhesion|signal transduction	cleavage furrow|lamellipodium|perinuclear region of cytoplasm	catalytic activity			breast(1)|endometrium(3)|lung(2)|ovary(2)|upper_aerodigestive_tract(1)	9						CAGTTTCATCCAGGCCAAGAG	0.662000													8	44					3.86212e-05	4.31752e-05	1	1	0
LSM14A	26065	broad.mit.edu	37	19	34699902	34699902	+	Missense_Mutation	SNP	G	G	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr19:34699902G>T	ENST00000544216.3	+	4	561	c.484G>T	c.(484-486)Gtt>Ttt	p.V162F	LSM14A_ENST00000433627.5_Missense_Mutation_p.V162F|LSM14A_ENST00000540746.2_Intron	NM_015578.2	NP_056393.2	Q8ND56	LS14A_HUMAN	LSM14A, SCD6 homolog A (S. cerevisiae)	162					cytoplasmic mRNA processing body assembly|multicellular organismal development|regulation of translation	cytoplasmic mRNA processing body|intracellular membrane-bounded organelle|stress granule				breast(1)|endometrium(4)|kidney(1)|large_intestine(8)|lung(7)|skin(1)	22	Esophageal squamous(110;0.162)					AAGTAGTGCGGTTGGTTCTGC	0.348000													16	22					1.99824e-07	2.43543e-07	1	1	0
KCNH7	90134	broad.mit.edu	37	2	163393470	163393470	+	Missense_Mutation	SNP	C	C	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr2:163393470C>T	ENST00000332142.5	-	3	527	c.428G>A	c.(427-429)aGg>aAg	p.R143K	KCNH7_ENST00000328032.4_Missense_Mutation_p.R143K	NM_033272.3	NP_150375.2	Q9NS40	KCNH7_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 7	143	PAC.				regulation of transcription, DNA-dependent	integral to membrane	protein binding|signal transducer activity			NS(1)|biliary_tract(1)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(22)|lung(53)|ovary(3)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(3)	108					Ibutilide(DB00308)	TGGGTTTACCCTCTCTGGGGT	0.378000													12	120					0	0	1	0	0
SIX3	6496	broad.mit.edu	37	2	45169367	45169367	+	Missense_Mutation	SNP	G	G	C			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr2:45169367G>C	ENST00000260653.3	+	1	466	c.124G>C	c.(124-126)Ggc>Cgc	p.G42R		NM_005413.3	NP_005404.1	O95343	SIX3_HUMAN	SIX homeobox 3	42	Poly-Gly.				visual perception	nucleus				haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(7)|skin(1)	11		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)				gggaggcggcggcggcgcggg	0.746000													10	68					0	0	1	0	0
BCR	613	broad.mit.edu	37	22	23523711	23523711	+	Silent	SNP	G	G	C			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr22:23523711G>C	ENST00000305877.8	+	1	1315	c.564G>C	c.(562-564)ctG>ctC	p.L188L	BCR_ENST00000359540.3_Silent_p.L188L|BCR_ENST00000398512.5_Silent_p.L188L	NM_004327.3	NP_004318.3	P11274	BCR_HUMAN	breakpoint cluster region	188	Kinase.				regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	ATP binding|GTPase activator activity|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity		BCR/JAK2(6)	central_nervous_system(3)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(9)|ovary(1)|prostate(1)|skin(4)|stomach(1)|urinary_tract(1)	35						AGCGCGGCCTGGTGAAGGTCA	0.652000			T	"""ABL1,  FGFR1, JAK2 """	"""CML, ALL, AML"""								13	58					0	0	1	0	0
DNAH14	127602	broad.mit.edu	37	1	225155208	225155208	+	Missense_Mutation	SNP	G	G	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr1:225155208G>T	ENST00000430092.1	+	6	789	c.574G>T	c.(574-576)Gat>Tat	p.D192Y	DNAH14_ENST00000439375.2_Missense_Mutation_p.D192Y|DNAH14_ENST00000366848.1_Missense_Mutation_p.D192Y|DNAH14_ENST00000400952.3_Missense_Mutation_p.D192Y|DNAH14_ENST00000366849.1_Missense_Mutation_p.D192Y|DNAH14_ENST00000366850.3_Missense_Mutation_p.D192Y	NM_001373.1	NP_001364.1	Q0VDD8	DYH14_HUMAN	dynein, axonemal, heavy chain 14	319					microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|microtubule motor activity			NS(2)|breast(3)|central_nervous_system(3)|endometrium(8)|kidney(4)|large_intestine(2)|lung(2)|skin(2)|stomach(1)	27						CAATCCATATGATCTTCAGGT	0.313000													15	146					2.23348e-06	2.62794e-06	1	1	0
HOXC13	3229	broad.mit.edu	37	12	54333329	54333329	+	Silent	SNP	C	C	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr12:54333329C>T	ENST00000243056.3	+	1	795	c.639C>T	c.(637-639)ggC>ggT	p.G213G	HOXC-AS5_ENST00000512916.2_RNA	NM_017410.2	NP_059106.2	P31276	HXC13_HUMAN	homeobox C13	213						nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|large_intestine(1)|skin(1)	3						CCGTCGAAGGCTACCAGCACT	0.662000			T	NUP98	AML								6	25					0	0	1	0	0
GRM7	2917	broad.mit.edu	37	3	7721755	7721755	+	Missense_Mutation	SNP	C	C	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr3:7721755C>A	ENST00000486284.1	+	9	2745	c.2471C>A	c.(2470-2472)aCg>aAg	p.T824K	GRM7_ENST00000402647.2_Missense_Mutation_p.T824K|GRM7_ENST00000389336.4_Missense_Mutation_p.T824K|GRM7_ENST00000403881.1_Missense_Mutation_p.T824K|GRM7_ENST00000357716.4_Missense_Mutation_p.T824K	NM_181874.2	NP_870989.1	Q14831	GRM7_HUMAN	glutamate receptor, metabotropic 7	824					negative regulation of adenylate cyclase activity|negative regulation of cAMP biosynthetic process|negative regulation of glutamate secretion|sensory perception of smell|sensory perception of sound|synaptic transmission	asymmetric synapse|axon|cell cortex|dendritic shaft|integral to plasma membrane|postsynaptic membrane|presynaptic active zone	adenylate cyclase inhibitor activity|calcium ion binding|glutamate binding|group III metabotropic glutamate receptor activity|PDZ domain binding|serine binding	p.T824M(1)		breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(14)|lung(35)|ovary(4)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	76					L-Glutamic Acid(DB00142)	CAAACTACCACGCTTACAATC	0.438000													9	35					3.09899e-07	3.74461e-07	1	1	0
HPS5	11234	broad.mit.edu	37	11	18314518	18314518	+	Missense_Mutation	SNP	T	T	C			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr11:18314518T>C	ENST00000396253.3	-	14	1910	c.1448A>G	c.(1447-1449)gAa>gGa	p.E483G	HPS5_ENST00000352460.3_Intron|HPS5_ENST00000438420.2_Missense_Mutation_p.E483G|HPS5_ENST00000349215.3_Missense_Mutation_p.E597G	NM_007216.3	NP_009147.3	Q9UPZ3	HPS5_HUMAN	Hermansky-Pudlak syndrome 5	597						cytosol				breast(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(17)|ovary(1)|pancreas(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	30						TACCTCTTTTTCCTCCCTAAA	0.418000									Hermansky-Pudlak syndrome				13	50					0	0	1	0	0
VAV1	7409	broad.mit.edu	37	19	6848051	6848051	+	Silent	SNP	G	G	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr19:6848051G>T	ENST00000304076.2	+	22	2083	c.1989G>T	c.(1987-1989)ctG>ctT	p.L663L	VAV1_ENST00000539284.1_Silent_p.L588L|VAV1_ENST00000599806.1_Silent_p.L630L|VAV1_ENST00000596764.1_Silent_p.L653L|VAV1_ENST00000602142.1_Silent_p.L685L	NM_001258206.1	NP_001245135.1	P15498	VAV_HUMAN	vav 1 guanine nucleotide exchange factor	685					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|platelet activation|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|T cell costimulation	cytosol|plasma membrane	metal ion binding|protein binding|sequence-specific DNA binding transcription factor activity			biliary_tract(1)|breast(3)|central_nervous_system(2)|endometrium(3)|kidney(5)|large_intestine(16)|lung(18)|ovary(5)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)	62						AGAGCATCCTGGCCAACCGCT	0.587000													32	82					3.90053e-15	5.50991e-15	1	1	0
IGKV1-17	28937	broad.mit.edu	37	2	89416903	89416903	+	RNA	SNP	G	G	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr2:89416903G>T	ENST00000490686.1	-	0	307																											GATTGTGAGAGTGAATTCTGT	0.488000													12	135					4.7546e-09	6.08047e-09	1	1	0
NRIP1	8204	broad.mit.edu	37	21	16339464	16339464	+	Missense_Mutation	SNP	C	C	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr21:16339464C>A	ENST00000400202.1	-	3	1762	c.1050G>T	c.(1048-1050)atG>atT	p.M350I	NRIP1_ENST00000400199.1_Missense_Mutation_p.M350I|NRIP1_ENST00000318948.4_Missense_Mutation_p.M350I			P48552	NRIP1_HUMAN	nuclear receptor interacting protein 1	350					androgen receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		androgen receptor binding|estrogen receptor binding|glucocorticoid receptor binding|transcription coactivator activity|transcription corepressor activity			cervix(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(6)|lung(13)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(4)	39				Epithelial(23;1.19e-05)|all cancers(11;4.64e-05)|COAD - Colon adenocarcinoma(22;0.000232)|Colorectal(24;0.0006)|OV - Ovarian serous cystadenocarcinoma(11;0.00418)|Lung(58;0.199)|LUSC - Lung squamous cell carcinoma(23;0.24)		GAATGATACCCATTGGATTTT	0.373000													14	60					4.3838e-07	5.26483e-07	1	1	0
D2HGDH	728294	broad.mit.edu	37	2	242707234	242707234	+	Silent	SNP	C	C	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr2:242707234C>T	ENST00000321264.4	+	10	1625	c.1416C>T	c.(1414-1416)gtC>gtT	p.V472V	D2HGDH_ENST00000486953.1_3'UTR|D2HGDH_ENST00000403782.1_Silent_p.V338V	NM_152783.3	NP_689996.4	Q8N465	D2HDH_HUMAN	D-2-hydroxyglutarate dehydrogenase	472					2-oxoglutarate metabolic process|cellular protein metabolic process|response to cobalt ion|response to manganese ion|response to zinc ion	mitochondrial matrix	(R)-2-hydroxyglutarate dehydrogenase activity|flavin adenine dinucleotide binding|protein binding			breast(1)|endometrium(3)|lung(10)|skin(1)|urinary_tract(1)	16		all_cancers(19;1.09e-40)|all_epithelial(40;2.03e-18)|Breast(86;1.53e-05)|all_lung(227;0.00338)|Renal(207;0.00502)|Ovarian(221;0.00716)|Lung NSC(271;0.012)|Esophageal squamous(248;0.129)|Melanoma(123;0.144)|all_hematologic(139;0.158)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;4.59e-33)|all cancers(36;9.89e-31)|OV - Ovarian serous cystadenocarcinoma(60;7.89e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;1.63e-06)|Lung(119;0.000152)|LUSC - Lung squamous cell carcinoma(224;0.00154)|Colorectal(34;0.0129)|COAD - Colon adenocarcinoma(134;0.0833)		AGGGCAGCGTCAGCGCGGAGC	0.692000													12	44					0	0	1	0	0
SLC5A8	160728	broad.mit.edu	37	12	101560366	101560366	+	Missense_Mutation	SNP	G	G	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr12:101560366G>T	ENST00000536262.2	-	12	1990	c.1432C>A	c.(1432-1434)Caa>Aaa	p.Q478K		NM_145913.3	NP_666018.3	Q8N695	SC5A8_HUMAN	solute carrier family 5 (sodium/monocarboxylate cotransporter), member 8	478					apoptosis|sodium ion transport	apical plasma membrane|integral to membrane	monocarboxylic acid transmembrane transporter activity|passive transmembrane transporter activity|symporter activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(9)|lung(29)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	47						TTACAGCCTTGGATATCAAGG	0.393000													7	28					1.06961e-07	1.31665e-07	1	1	0
SYCP2	10388	broad.mit.edu	37	20	58442798	58442798	+	Missense_Mutation	SNP	T	T	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr20:58442798T>A	ENST00000357552.3	-	39	4318	c.4093A>T	c.(4093-4095)Agg>Tgg	p.R1365W	SYCP2_ENST00000371001.2_Missense_Mutation_p.R1365W			Q9BX26	SYCP2_HUMAN	synaptonemal complex protein 2	1365					cell division|meiotic prophase I|synaptonemal complex assembly		DNA binding			NS(4)|breast(2)|central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(14)|lung(12)|ovary(4)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	53	all_lung(29;0.00344)		BRCA - Breast invasive adenocarcinoma(7;1.19e-09)			GAATTGAGCCTCTCGTAAGTC	0.323000													8	38					0	0	1	0	0
DTX2	113878	broad.mit.edu	37	7	76112138	76112138	+	Silent	SNP	C	C	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr7:76112138C>T	ENST00000324432.5	+	5	1092	c.582C>T	c.(580-582)gtC>gtT	p.V194V	DTX2_ENST00000307569.8_Silent_p.V194V|DTX2_ENST00000446600.1_Silent_p.V103V|DTX2_ENST00000446820.2_Silent_p.V194V|DTX2_ENST00000430490.2_Silent_p.V194V|DTX2_ENST00000413936.2_Silent_p.V194V	NM_020892.2	NP_065943.2	Q86UW9	DTX2_HUMAN	deltex homolog 2 (Drosophila)	194					Notch signaling pathway	cytoplasm|nucleus	protein binding|zinc ion binding			NS(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(14)|ovary(1)|skin(1)|stomach(2)	27						ACACAGGCGTCGCCTGCTCTT	0.672000													30	156					0	0	1	0	0
RPS4Y2	140032	broad.mit.edu	37	Y	22921762	22921762	+	Silent	SNP	T	T	C			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chrY:22921762T>C	ENST00000288666.5	+	3	90	c.90T>C	c.(88-90)cgT>cgC	p.R30R		NM_001039567.2	NP_001034656.1	Q8TD47	RS4Y2_HUMAN	ribosomal protein S4, Y-linked 2	30					translation	ribosome	rRNA binding|structural constituent of ribosome			lung(2)	2						AGGCACCTCGTCCATCGACAG	0.468000													31	29					0	0	1	0	0
C5orf51	285636	broad.mit.edu	37	5	41904501	41904501	+	Missense_Mutation	SNP	G	G	C			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr5:41904501G>C	ENST00000381647.2	+	1	51	c.32G>C	c.(31-33)cGa>cCa	p.R11P	C5orf51_ENST00000505931.2_Intron	NM_175921.4	NP_787117.3	A6NDU8	CE051_HUMAN	chromosome 5 open reading frame 51	11										endometrium(1)|large_intestine(5)|lung(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	11						GTGGTGAGACGAGTGGAAGAG	0.662000													21	38					0	0	1	0	0
FAM47B	170062	broad.mit.edu	37	X	34961113	34961113	+	Missense_Mutation	SNP	G	G	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chrX:34961113G>T	ENST00000329357.5	+	1	201	c.165G>T	c.(163-165)atG>atT	p.M55I		NM_152631.2	NP_689844.2	Q8NA70	FA47B_HUMAN	family with sequence similarity 47, member B	55										breast(3)|central_nervous_system(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(13)|lung(28)|ovary(4)|prostate(3)|skin(2)|upper_aerodigestive_tract(3)	71						CGGAGGGCATGGACGACTTCC	0.557000													23	26					7.87624e-14	1.10312e-13	1	1	0
LRRC4C	57689	broad.mit.edu	37	11	40136549	40136549	+	Missense_Mutation	SNP	C	C	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr11:40136549C>A	ENST00000278198.2	-	2	3257	c.1294G>T	c.(1294-1296)Gtt>Ttt	p.V432F	LRRC4C_ENST00000527150.1_Missense_Mutation_p.V432F|LRRC4C_ENST00000528697.1_Missense_Mutation_p.V432F|LRRC4C_ENST00000530763.1_Missense_Mutation_p.V432F			Q9HCJ2	LRC4C_HUMAN	leucine rich repeat containing 4C	432	Ig-like C2-type.				regulation of axonogenesis	integral to membrane	protein binding			NS(2)|central_nervous_system(3)|endometrium(1)|large_intestine(14)|lung(43)|ovary(5)|prostate(2)|skin(9)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	86		all_lung(304;0.0575)|Lung NSC(402;0.138)				GTATTCCCAACGGAATTACTC	0.438000													13	137					9.16793e-09	1.1679e-08	1	1	0
EXOC3	11336	broad.mit.edu	37	5	453722	453722	+	Missense_Mutation	SNP	C	C	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr5:453722C>T	ENST00000512944.1	+	4	791	c.602C>T	c.(601-603)aCt>aTt	p.T201I	EXOC3_ENST00000315013.5_Missense_Mutation_p.T201I	NM_007277.4	NP_009208.2	O60645	EXOC3_HUMAN	exocyst complex component 3	212					exocytosis|protein transport					breast(2)|cervix(1)|endometrium(4)|large_intestine(1)|lung(13)|ovary(1)|urinary_tract(1)	23		Ovarian(839;0.0563)	Epithelial(17;0.000529)|OV - Ovarian serous cystadenocarcinoma(19;0.00153)|all cancers(22;0.00186)|Lung(60;0.0863)			TCACTGGTCACTGTCCGCCGT	0.547000													27	116					0	0	1	0	0
SERPINB7	8710	broad.mit.edu	37	18	61465961	61465961	+	Missense_Mutation	SNP	G	G	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr18:61465961G>A	ENST00000398019.2	+	6	903	c.578G>A	c.(577-579)tGc>tAc	p.C193Y	SERPINB7_ENST00000540675.1_Missense_Mutation_p.C176Y|SERPINB7_ENST00000336429.2_Missense_Mutation_p.C193Y|SERPINB7_ENST00000546027.1_Missense_Mutation_p.C193Y	NM_003784.3	NP_003775.1	O75635	SPB7_HUMAN	serpin peptidase inhibitor, clade B (ovalbumin), member 7	193					regulation of proteolysis	cytoplasm	serine-type endopeptidase inhibitor activity			central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(3)|lung(14)|prostate(1)|skin(3)	27		Esophageal squamous(42;0.129)				ACCATAAATTGCCATTTCAAA	0.408000													29	54					0	0	1	0	0
UNC79	57578	broad.mit.edu	37	14	94129022	94129022	+	Missense_Mutation	SNP	G	G	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr14:94129022G>T	ENST00000553484.1	+	42	6935	c.6781G>T	c.(6781-6783)Gtg>Ttg	p.V2261L	UNC79_ENST00000393151.2_Missense_Mutation_p.V2239L|UNC79_ENST00000555664.1_Missense_Mutation_p.V2200L|UNC79_ENST00000256339.4_Missense_Mutation_p.V2062L			Q9P2D8	UNC79_HUMAN	unc-79 homolog (C. elegans)	2239						integral to membrane				breast(3)|cervix(2)|endometrium(10)|kidney(7)|large_intestine(18)|liver(1)|lung(64)|ovary(1)|prostate(5)|skin(3)|urinary_tract(4)	118						GGCCTACCTGGTGGAGCTGTG	0.418000													10	17					1.58986e-06	1.87737e-06	1	1	0
OR5D13	390142	broad.mit.edu	37	11	55541155	55541155	+	Missense_Mutation	SNP	C	C	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr11:55541155C>A	ENST00000361760.1	+	1	242	c.242C>A	c.(241-243)cCt>cAt	p.P81H		NM_001001967.1	NP_001001967.1	Q8NGL4	OR5DD_HUMAN	olfactory receptor, family 5, subfamily D, member 13	81					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|liver(1)|lung(20)|ovary(1)|pancreas(2)|skin(2)|stomach(1)|urinary_tract(1)	40		all_epithelial(135;0.196)				GTAGTTACACCTAAACTGTTG	0.368000													21	87					2.4624e-09	3.17376e-09	1	1	0
FAM71C	196472	broad.mit.edu	37	12	100042346	100042346	+	Missense_Mutation	SNP	A	A	C			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr12:100042346A>C	ENST00000324341.1	+	1	816	c.394A>C	c.(394-396)Aac>Cac	p.N132H	ANKS1B_ENST00000329257.7_Intron|ANKS1B_ENST00000547776.2_Intron|ANKS1B_ENST00000547010.1_Intron	NM_153364.3	NP_699195.1	Q8NEG0	FA71C_HUMAN	family with sequence similarity 71, member C	132										breast(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(8)|upper_aerodigestive_tract(1)|urinary_tract(1)	18				OV - Ovarian serous cystadenocarcinoma(2;0.00733)|Epithelial(2;0.0385)|all cancers(2;0.19)		AACCATCCACAACAGCGTAAA	0.483000													24	85					0	0	1	0	0
PDIA2	64714	broad.mit.edu	37	16	334453	334453	+	Missense_Mutation	SNP	C	C	G			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr16:334453C>G	ENST00000219406.6	+	2	284	c.266C>G	c.(265-267)gCg>gGg	p.A89G	PDIA2_ENST00000404312.1_Missense_Mutation_p.A89G	NM_006849.2	NP_006840.2	Q13087	PDIA2_HUMAN	protein disulfide isomerase family A, member 2	89	Thioredoxin 1.				apoptosis|cell redox homeostasis|glycerol ether metabolic process|protein folding|protein retention in ER lumen|response to hypoxia	endoplasmic reticulum lumen	electron carrier activity|protein binding|protein disulfide isomerase activity|protein disulfide oxidoreductase activity|steroid binding			breast(1)|central_nervous_system(4)|kidney(3)|lung(7)|skin(1)|upper_aerodigestive_tract(1)	17		all_cancers(16;6.71e-07)|all_epithelial(16;1.59e-06)|Hepatocellular(16;0.000105)|Lung NSC(18;0.00769)|all_lung(18;0.0186)				GCCGTGCTCGCGGCCGAGTCA	0.687000													4	9					0	0	1	0	0
TMEM63B	55362	broad.mit.edu	37	6	44106231	44106231	+	Missense_Mutation	SNP	G	G	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr6:44106231G>T	ENST00000259746.9	+	6	567	c.384G>T	c.(382-384)tgG>tgT	p.W128C	TMEM63B_ENST00000323267.6_Missense_Mutation_p.W128C			Q5T3F8	TM63B_HUMAN	transmembrane protein 63B	128						integral to membrane	nucleotide binding|protein binding			breast(3)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(8)|ovary(1)|pancreas(2)|prostate(2)|stomach(4)	35	all_cancers(18;1.66e-06)|Lung NSC(15;0.00108)|all_lung(25;0.00278)|Hepatocellular(11;0.00309)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0215)			TCTGTTCCTGGCTGACAGCCA	0.517000													41	165					2.64894e-19	3.90412e-19	1	1	0
MAP1LC3B2	643246	broad.mit.edu	37	12	117013999	117013999	+	Missense_Mutation	SNP	C	C	G			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr12:117013999C>G	ENST00000306985.4	+	2	406	c.252C>G	c.(250-252)aaC>aaG	p.N84K	MAP1LC3B2_ENST00000556529.1_Missense_Mutation_p.N84K	NM_001085481.1	NP_001078950.1	A6NCE7	MP3B2_HUMAN	microtubule-associated protein 1 light chain 3 beta 2	84					autophagy	autophagic vacuole membrane|cytoplasmic vesicle|endomembrane system|microtubule				breast(1)|large_intestine(2)|lung(3)	6						TGTTGGTGAACGGACACAGCA	0.478000													17	78					0	0	1	0	0
TUBA3C	7278	broad.mit.edu	37	13	19752451	19752451	+	Missense_Mutation	SNP	C	C	A	rs145210942		TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr13:19752451C>A	ENST00000400113.3	-	3	414	c.310G>T	c.(310-312)Gcc>Tcc	p.A104S		NM_006001.2	NP_005992.1	Q13748	TBA3C_HUMAN	tubulin, alpha 3c	104					'de novo' posttranslational protein folding|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|protein binding|structural molecule activity			NS(1)|biliary_tract(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(12)|lung(33)|ovary(4)|prostate(7)|skin(7)|urinary_tract(1)	72		all_cancers(29;1.31e-20)|all_epithelial(30;1.59e-20)|all_lung(29;6.91e-20)|Lung NSC(5;9.25e-17)|Hepatocellular(1;0.0207)|Lung SC(185;0.0262)|Ovarian(182;0.162)		all cancers(112;6.78e-06)|Epithelial(112;3.79e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00172)|Lung(94;0.0186)|LUSC - Lung squamous cell carcinoma(192;0.108)		TGGCCTCTGGCGTAATTATTG	0.532000													32	101					3.90053e-15	5.50991e-15	1	1	0
TCTN1	79600	broad.mit.edu	37	12	111066760	111066760	+	Missense_Mutation	SNP	A	A	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr12:111066760A>T	ENST00000550703.2	+	4	817	c.661A>T	c.(661-663)Aca>Tca	p.T221S	TCTN1_ENST00000397655.3_Intron|TCTN1_ENST00000397659.4_Intron|TCTN1_ENST00000551590.1_Intron|TCTN1_ENST00000551555.2_Intron|TCTN1_ENST00000377654.3_Intron|HVCN1_ENST00000548312.1_Intron			Q2MV58	TECT1_HUMAN	tectonic family member 1	0					multicellular organismal development	extracellular region				NS(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(9)|urinary_tract(1)	15						TCATCCCATCACAAATATCTT	0.353000													3	19					0	0	1	0	0
PRKD3	23683	broad.mit.edu	37	2	37481388	37481388	+	Missense_Mutation	SNP	G	G	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr2:37481388G>A	ENST00000379066.1	-	18	3220	c.2458C>T	c.(2458-2460)Cgt>Tgt	p.R820C	PRKD3_ENST00000234179.2_Missense_Mutation_p.R820C			O94806	KPCD3_HUMAN	protein kinase D3	820	Protein kinase.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction	cytoplasm|membrane|nucleus	ATP binding|metal ion binding|protein binding|protein kinase C activity			breast(3)|central_nervous_system(2)|kidney(3)|large_intestine(8)|lung(9)|ovary(3)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	33		all_hematologic(82;0.21)				ACACTGTAACGTTTTCTCATC	0.373000													11	50					0	0	1	0	0
LAMC1	3915	broad.mit.edu	37	1	183079630	183079630	+	Missense_Mutation	SNP	T	T	C			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr1:183079630T>C	ENST00000258341.4	+	4	1119	c.862T>C	c.(862-864)Tgt>Cgt	p.C288R		NM_002293.3	NP_002284.3	P11047	LAMC1_HUMAN	laminin, gamma 1 (formerly LAMB2)	288	Laminin EGF-like 1.				axon guidance|cell migration|endoderm development|extracellular matrix disassembly|hemidesmosome assembly|positive regulation of epithelial cell proliferation|protein complex assembly|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-11 complex	extracellular matrix structural constituent			NS(2)|breast(5)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(17)|lung(27)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)	76					Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	CAGATGTAAATGTAATGGACA	0.383000													13	106					0	0	1	0	0
MOB2	81532	broad.mit.edu	37	11	1492549	1492549	+	Nonsense_Mutation	SNP	C	C	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr11:1492549C>A	ENST00000329957.6	-	4	655	c.466G>T	c.(466-468)Gag>Tag	p.E156*	MOB2_ENST00000526462.1_5'UTR	NM_001172223.1	NP_001165694.1	Q70IA6	MOB2_HUMAN	MOB kinase activator 2	125						nucleus|perinuclear region of cytoplasm	metal ion binding			breast(1)|kidney(2)|lung(1)	4						AACACGTCCTCATCCGTCACC	0.577000													6	33					0.0215528	0.0220675	1	1	0
KCNJ3	3760	broad.mit.edu	37	2	155711507	155711507	+	Silent	SNP	T	T	C			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr2:155711507T>C	ENST00000295101.2	+	3	1665	c.1188T>C	c.(1186-1188)acT>acC	p.T396T	KCNJ3_ENST00000493505.1_3'UTR|KCNJ3_ENST00000544049.1_3'UTR	NM_001260509.1|NM_002239.3	NP_001247438.1|NP_002230.1	P48549	IRK3_HUMAN	potassium inwardly-rectifying channel, subfamily J, member 3	396					synaptic transmission	voltage-gated potassium channel complex	G-protein activated inward rectifier potassium channel activity|protein binding			breast(2)|endometrium(2)|kidney(3)|large_intestine(9)|lung(30)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	54					Halothane(DB01159)	ATGATATTACTACAAAACTAC	0.378000													40	96					0	0	1	0	0
LILRB2	10288	broad.mit.edu	37	19	54783452	54783452	+	Missense_Mutation	SNP	A	A	C			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr19:54783452A>C	ENST00000391748.1	-	5	533	c.406T>G	c.(406-408)Tca>Gca	p.S136A	LILRB2_ENST00000391746.1_Missense_Mutation_p.S136A|LILRB2_ENST00000314446.5_Missense_Mutation_p.S136A|LILRB2_ENST00000434421.1_Missense_Mutation_p.S20A|LILRB2_ENST00000391749.4_Missense_Mutation_p.S136A	NM_001278403.1	NP_001265332.1	Q8N423	LIRB2_HUMAN	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2	136	Ig-like C2-type 2.				cell surface receptor linked signaling pathway|cell-cell signaling|cellular defense response|immune response|regulation of immune response	integral to plasma membrane|membrane fraction	receptor activity			breast(2)|endometrium(3)|kidney(1)|large_intestine(4)|lung(30)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	44	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		CTTCCTCCTGAGGTCACCACA	0.572000													39	90					0	0	1	0	0
HMGXB4	10042	broad.mit.edu	37	22	35659194	35659194	+	Missense_Mutation	SNP	G	G	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr22:35659194G>T	ENST00000216106.5	+	3	283	c.155G>T	c.(154-156)aGg>aTg	p.R52M	HMGXB4_ENST00000444518.2_5'UTR	NM_001003681.2	NP_001003681.1	Q9UGU5	HMGX4_HUMAN	HMG box domain containing 4	52					endosome to lysosome transport|negative regulation of Wnt receptor signaling pathway|Wnt receptor signaling pathway	NURF complex	DNA binding			breast(1)|endometrium(1)|large_intestine(6)|liver(1)|lung(4)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	19						GCTCAGGTCAGGAATTCTTCC	0.363000													8	40					3.09899e-07	3.74461e-07	1	1	0
LRP1B	53353	broad.mit.edu	37	2	141253296	141253296	+	Missense_Mutation	SNP	G	G	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr2:141253296G>T	ENST00000389484.3	-	56	9843	c.8872C>A	c.(8872-8874)Caa>Aaa	p.Q2958K		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	2958	EGF-like 6.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		TCCTTCAGTTGGAATCCAGGC	0.398000										TSP Lung(27;0.18)			7	44					0.0293803	0.0299576	1	1	0
SPATA22	84690	broad.mit.edu	37	17	3343561	3343561	+	Missense_Mutation	SNP	G	G	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr17:3343561G>T	ENST00000573128.1	-	9	1455	c.972C>A	c.(970-972)aaC>aaA	p.N324K	SPATA22_ENST00000572969.1_Missense_Mutation_p.N324K|SPATA22_ENST00000575375.1_Missense_Mutation_p.N324K|SPATA22_ENST00000355380.4_Missense_Mutation_p.N281K|SPATA22_ENST00000397168.3_Missense_Mutation_p.N324K|SPATA22_ENST00000541913.1_Missense_Mutation_p.N308K|SPATA22_ENST00000268981.5_3'UTR			Q8NHS9	SPT22_HUMAN	spermatogenesis associated 22	324										breast(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(8)|skin(2)	19						ATTGGAAAATGTTCTTTTTCT	0.363000													10	33					0.00829132	0.00866021	1	1	0
DPF3	8110	broad.mit.edu	37	14	73141046	73141046	+	Missense_Mutation	SNP	G	G	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr14:73141046G>T	ENST00000541685.1	-	8	785	c.773C>A	c.(772-774)cCc>cAc	p.P258H	DPF3_ENST00000546183.1_Missense_Mutation_p.P268H|DPF3_ENST00000557704.1_5'UTR|DPF3_ENST00000556509.1_Missense_Mutation_p.P258H	NM_012074.3	NP_036206.3	Q92784	DPF3_HUMAN	D4, zinc and double PHD fingers, family 3	258					chromatin modification|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nBAF complex	nucleic acid binding|zinc ion binding			central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(13)|ovary(1)	22				BRCA - Breast invasive adenocarcinoma(234;0.00649)|OV - Ovarian serous cystadenocarcinoma(108;0.0654)		GTAGTTATTGGGAATGACTGT	0.507000													9	11					3.86212e-05	4.31752e-05	1	1	0
MUC16	94025	broad.mit.edu	37	19	9086989	9086989	+	Missense_Mutation	SNP	G	G	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr19:9086989G>T	ENST00000397910.4	-	1	5029	c.4826C>A	c.(4825-4827)cCa>cAa	p.P1609Q		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	1609	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GTCTGTAGATGGTTTCCAAAA	0.502000													57	95					7.50695e-29	1.14403e-28	1	1	0
OR52J3	119679	broad.mit.edu	37	11	5068689	5068689	+	Nonstop_Mutation	SNP	T	T	C			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr11:5068689T>C	ENST00000380370.1	+	1	934	c.934T>C	c.(934-936)Taa>Caa	p.*312Q		NM_001001916.2	NP_001001916.2	Q8NH60	O52J3_HUMAN	olfactory receptor, family 52, subfamily J, member 3	0					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(1)|kidney(6)|large_intestine(6)|lung(19)|ovary(1)|skin(2)	36		Medulloblastoma(188;0.00131)|all_neural(188;0.0189)|Breast(177;0.0204)		Epithelial(150;9.29e-10)|BRCA - Breast invasive adenocarcinoma(625;0.135)|LUSC - Lung squamous cell carcinoma(625;0.19)		TACTAAAAAATAAGACTCTTA	0.373000													9	49					0	0	1	0	0
GNGT2	2793	broad.mit.edu	37	17	47284190	47284190	+	Missense_Mutation	SNP	C	C	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr17:47284190C>A	ENST00000511277.1	-	4	318	c.139G>T	c.(139-141)Gat>Tat	p.D47Y	GNGT2_ENST00000300406.2_Missense_Mutation_p.D47Y|GNGT2_ENST00000515635.1_Missense_Mutation_p.D47Y|GNGT2_ENST00000503070.1_Missense_Mutation_p.D47Y|GNGT2_ENST00000507680.1_Missense_Mutation_p.D47Y|GNGT2_ENST00000511673.1_Missense_Mutation_p.D47Y	NM_001198756.1	NP_001185685.1	O14610	GBGT2_HUMAN	guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2	47					G-protein coupled receptor protein signaling pathway|phototransduction|synaptic transmission	extracellular region|heterotrimeric G-protein complex	GTPase activity|signal transducer activity			endometrium(1)|lung(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	4			Epithelial(5;6.37e-06)|all cancers(6;6.36e-05)			AGAAAAGGATCGTTTCCTGCT	0.488000													25	89					1.64293e-13	2.29452e-13	1	1	0
ROBO4	54538	broad.mit.edu	37	11	124754983	124754983	+	Missense_Mutation	SNP	G	G	C			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr11:124754983G>C	ENST00000306534.3	-	17	3440	c.2955C>G	c.(2953-2955)atC>atG	p.I985M	RP11-664I21.5_ENST00000524453.1_RNA|ROBO4_ENST00000533054.1_Missense_Mutation_p.I840M	NM_019055.5	NP_061928.4	Q8WZ75	ROBO4_HUMAN	roundabout, axon guidance receptor, homolog 4 (Drosophila)	985					angiogenesis|cell differentiation	integral to membrane	receptor activity			NS(2)|breast(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(11)|lung(42)|ovary(1)|prostate(4)|skin(5)|urinary_tract(3)	76	all_hematologic(175;0.215)	Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|Breast(109;0.171)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.5e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0301)		TCTGGGAAGAGATCTGAGAGT	0.602000													10	72					0	0	1	0	0
WNK1	65125	broad.mit.edu	37	12	863210	863210	+	Missense_Mutation	SNP	C	C	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr12:863210C>A	ENST00000537687.1	+	1	1122	c.479C>A	c.(478-480)aCc>aAc	p.T160N	WNK1_ENST00000447667.2_Missense_Mutation_p.T160N|WNK1_ENST00000535572.1_Missense_Mutation_p.T160N|WNK1_ENST00000315939.6_Missense_Mutation_p.T160N|WNK1_ENST00000530271.2_Missense_Mutation_p.T160N	NM_001184985.1|NM_213655.4	NP_001171914.1|NP_998820.3	Q9H4A3	WNK1_HUMAN	WNK lysine deficient protein kinase 1	160					intracellular protein kinase cascade|ion transport|neuron development	cytoplasm	ATP binding|protein binding|protein kinase inhibitor activity|protein serine/threonine kinase activity			breast(7)|central_nervous_system(1)|endometrium(3)|kidney(6)|large_intestine(15)|lung(43)|ovary(6)|prostate(3)|skin(7)|stomach(8)|upper_aerodigestive_tract(3)|urinary_tract(2)	104	all_cancers(10;0.00611)|all_epithelial(11;0.00825)|all_lung(10;0.0331)|Ovarian(42;0.0512)|Lung NSC(10;0.0632)		Epithelial(1;1.74e-08)|all cancers(1;7.04e-08)|OV - Ovarian serous cystadenocarcinoma(31;0.000423)|BRCA - Breast invasive adenocarcinoma(9;0.0149)|Colorectal(1;0.0197)			CCCAGCAGTACCAGCAAAGAC	0.721000													7	21					0.00198382	0.00210327	1	1	0
RYR1	6261	broad.mit.edu	37	19	39002948	39002948	+	Silent	SNP	C	C	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr19:39002948C>T	ENST00000355481.4	+	63	9428	c.9297C>T	c.(9295-9297)gcC>gcT	p.A3099A	RYR1_ENST00000359596.3_Silent_p.A3099A|RYR1_ENST00000360985.3_Silent_p.A3099A	NM_000540.2|NM_001042723.1	NP_000531.2|NP_001036188.1	P21817	RYR1_HUMAN	ryanodine receptor 1 (skeletal)	3099					muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(4)|autonomic_ganglia(2)|breast(3)|central_nervous_system(5)|endometrium(26)|haematopoietic_and_lymphoid_tissue(3)|kidney(34)|large_intestine(42)|liver(1)|lung(106)|ovary(11)|pancreas(5)|prostate(9)|skin(12)|stomach(11)|upper_aerodigestive_tract(4)|urinary_tract(7)	285	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	TCGAGAGTGCCTCGGAGGACA	0.612000													51	51					0	0	1	0	0
DNAJA3	9093	broad.mit.edu	37	16	4484477	4484477	+	Nonsense_Mutation	SNP	C	C	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr16:4484477C>T	ENST00000262375.6	+	2	381	c.304C>T	c.(304-306)Cga>Tga	p.R102*	DNAJA3_ENST00000572139.1_3'UTR|DNAJA3_ENST00000355296.4_Nonsense_Mutation_p.R102*|DNAJA3_ENST00000431375.2_Intron	NM_005147.5	NP_005138.3	Q96EY1	DNJA3_HUMAN	DnaJ (Hsp40) homolog, subfamily A, member 3	102	J.				activation of caspase activity|negative regulation of apoptosis|negative regulation of caspase activity|negative regulation of cell proliferation|negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of interferon-gamma-mediated signaling pathway|negative regulation of NF-kappaB transcription factor activity|negative regulation of protein kinase activity|neuromuscular junction development|positive regulation of apoptosis|positive regulation of protein ubiquitination|protein folding|protein stabilization|response to heat|response to interferon-gamma	cytosol|mitochondrial matrix|mitochondrial nucleoid|nucleus	ATP binding|heat shock protein binding|interferon-gamma receptor binding|metal ion binding|NF-kappaB binding|protein kinase binding			NS(1)|breast(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|ovary(2)|upper_aerodigestive_tract(2)	15						AGGAGTGCCTCGAAATGCCAG	0.413000													20	143					0	0	1	0	0
MND1	84057	broad.mit.edu	37	4	154318395	154318395	+	Nonsense_Mutation	SNP	G	G	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr4:154318395G>T	ENST00000240488.3	+	6	465	c.376G>T	c.(376-378)Gag>Tag	p.E126*	MND1_ENST00000504860.1_Nonsense_Mutation_p.E111*	NM_001253861.1|NM_032117.3	NP_001240790.1|NP_115493.1	Q9BWT6	MND1_HUMAN	meiotic nuclear divisions 1 homolog (S. cerevisiae)	126					DNA recombination|meiosis	nucleus	DNA binding			large_intestine(2)|lung(1)	3	all_hematologic(180;0.093)					GCTAGCAAAAGAGCTTTCTTC	0.358000													3	19					0.004672	0.00490585	1	1	0
RYR2	6262	broad.mit.edu	37	1	237777698	237777698	+	Missense_Mutation	SNP	T	T	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr1:237777698T>A	ENST00000366574.2	+	37	5587	c.5270T>A	c.(5269-5271)cTc>cAc	p.L1757H	RYR2_ENST00000542537.1_Missense_Mutation_p.L1741H|RYR2_ENST00000360064.6_Missense_Mutation_p.L1755H	NM_001035.2	NP_001026.2	Q92736	RYR2_HUMAN	ryanodine receptor 2 (cardiac)	1757	4 X approximate repeats.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			NS(4)|breast(8)|central_nervous_system(11)|cervix(2)|endometrium(39)|haematopoietic_and_lymphoid_tissue(5)|kidney(17)|large_intestine(83)|liver(4)|lung(353)|ovary(18)|pancreas(5)|prostate(12)|skin(8)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(4)	586	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			AGCACCTCCCTCAGGCCACGG	0.512000													11	82					0	0	1	0	0
SEC24D	9871	broad.mit.edu	37	4	119678977	119678977	+	Silent	SNP	T	T	C			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr4:119678977T>C	ENST00000379735.5	-	11	1594	c.1323A>G	c.(1321-1323)ccA>ccG	p.P441P	SEC24D_ENST00000511481.1_Silent_p.P71P|SEC24D_ENST00000419654.2_5'UTR|SEC24D_ENST00000280551.6_Silent_p.P440P|SEC24D_ENST00000429811.2_5'UTR|SEC24D_ENST00000505134.1_5'UTR	NM_014822.2	NP_055637.2	O94855	SC24D_HUMAN	SEC24 family member D	440					COPII vesicle coating|intracellular protein transport|post-translational protein modification|protein N-linked glycosylation via asparagine	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|Golgi membrane|perinuclear region of cytoplasm	zinc ion binding			breast(3)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(10)|lung(13)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	37						AGATAAAGGCTGGTGGGTTGG	0.338000													9	37					0	0	1	0	0
ABHD5	51099	broad.mit.edu	37	3	43744032	43744032	+	Missense_Mutation	SNP	C	C	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr3:43744032C>A	ENST00000458276.2	+	3	582	c.459C>A	c.(457-459)aaC>aaA	p.N153K		NM_016006.4	NP_057090.2	Q8WTS1	ABHD5_HUMAN	abhydrolase domain containing 5	153					cell differentiation|fatty acid metabolic process|negative regulation of sequestering of triglyceride|phosphatidic acid biosynthetic process|positive regulation of triglyceride catabolic process|triglyceride catabolic process	cytosol|lipid particle	1-acylglycerol-3-phosphate O-acyltransferase activity|lysophosphatidic acid acyltransferase activity			kidney(3)|large_intestine(2)|liver(2)|lung(5)|ovary(1)|skin(1)	14		Renal(3;0.0134)		KIRC - Kidney renal clear cell carcinoma(197;0.0546)|Kidney(197;0.0687)		TTGGGCACAACCTAGGTGGAT	0.463000													26	112					3.01185e-09	3.86677e-09	1	1	0
UPF2	26019	broad.mit.edu	37	10	12039734	12039734	+	Missense_Mutation	SNP	T	T	C			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr10:12039734T>C	ENST00000356352.2	-	7	2254	c.1781A>G	c.(1780-1782)aAc>aGc	p.N594S	UPF2_ENST00000357604.5_Missense_Mutation_p.N594S|UPF2_ENST00000397053.2_Missense_Mutation_p.N594S			Q9HAU5	RENT2_HUMAN	UPF2 regulator of nonsense transcripts homolog (yeast)	594	MIF4G 2.				mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	exon-exon junction complex|perinuclear region of cytoplasm	identical protein binding|RNA binding			breast(3)|central_nervous_system(3)|cervix(1)|endometrium(5)|kidney(6)|large_intestine(14)|lung(17)|ovary(2)|skin(3)|urinary_tract(2)	56		Renal(717;0.228)				TGTGTTCATGTTCATGCAAAA	0.343000													9	54					0	0	1	0	0
RNGTT	8732	broad.mit.edu	37	6	89324063	89324063	+	Missense_Mutation	SNP	C	C	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr6:89324063C>T	ENST00000369485.4	-	15	1744	c.1558G>A	c.(1558-1560)Gag>Aag	p.E520K	RNGTT_ENST00000265607.6_Missense_Mutation_p.E497K|RNGTT_ENST00000538899.1_Missense_Mutation_p.E437K	NM_003800.3	NP_003791.3	O60942	MCE1_HUMAN	RNA guanylyltransferase and 5'-phosphatase	520	GTase.				interspecies interaction between organisms|mRNA capping|transcription from RNA polymerase II promoter|viral reproduction	nucleoplasm	GTP binding|mRNA guanylyltransferase activity|polynucleotide 5'-phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			endometrium(1)|large_intestine(7)|lung(6)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)	21		all_cancers(76;4.07e-09)|Prostate(29;1.16e-10)|Acute lymphoblastic leukemia(125;1.49e-10)|all_hematologic(105;7.79e-07)|all_epithelial(107;6.86e-05)		BRCA - Breast invasive adenocarcinoma(108;0.151)		CTGTTGTTCTCAAATTTGCAT	0.358000													5	39					0	0	1	0	0
SGCD	6444	broad.mit.edu	37	5	156184638	156184638	+	Missense_Mutation	SNP	G	G	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr5:156184638G>A	ENST00000435422.3	+	7	1106	c.619G>A	c.(619-621)Gtg>Atg	p.V207M	SGCD_ENST00000447401.1_Missense_Mutation_p.V208M|SGCD_ENST00000517913.1_Missense_Mutation_p.V208M|SGCD_ENST00000337851.4_Missense_Mutation_p.V208M	NM_001128209.1	NP_001121681.1	Q92629	SGCD_HUMAN	sarcoglycan, delta (35kDa dystrophin-associated glycoprotein)	207					cytoskeleton organization|muscle organ development	cytoplasm|cytoskeleton|integral to membrane|sarcoglycan complex|sarcolemma				breast(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(16)|prostate(1)	24	Renal(175;0.00488)	Medulloblastoma(196;0.0378)|all_neural(177;0.106)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			CCCAAAAGGAGTGGAAATCAA	0.468000													4	12					0	0	1	0	0
ROS1	6098	broad.mit.edu	37	6	117662732	117662732	+	Missense_Mutation	SNP	C	C	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr6:117662732C>A	ENST00000368508.3	-	29	4931	c.4733G>T	c.(4732-4734)tGg>tTg	p.W1578L	GOPC_ENST00000467125.1_Intron|ROS1_ENST00000368507.3_Missense_Mutation_p.W1572L	NM_002944.2	NP_002935.2	P08922	ROS_HUMAN	c-ros oncogene 1 , receptor tyrosine kinase	1578	Fibronectin type-III 7.				transmembrane receptor protein tyrosine kinase signaling pathway	membrane fraction|sodium:potassium-exchanging ATPase complex	ATP binding|transmembrane receptor protein tyrosine kinase activity		TPM3_ENST00000368530/ROS1(4)|LRIG3/ROS1(2)|CD74_ENST00000009530/ROS1(32)|SLC34A2/ROS1(14)|EZR/ROS1(4)|GOPC/ROS1(14)|SDC4/ROS1(7)	NS(2)|breast(7)|central_nervous_system(5)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(28)|lung(56)|ovary(8)|prostate(5)|skin(19)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(3)	162		all_cancers(87;0.00846)|all_epithelial(87;0.0242)		GBM - Glioblastoma multiforme(226;0.0387)|OV - Ovarian serous cystadenocarcinoma(136;0.0954)|all cancers(137;0.137)		AGATTCTCTCCAAGATATAAT	0.433000			T	"""GOPC, SDC4, SLC34A2, EZR, LRIG3"""	"""glioblastoma, NSCLC"""								13	56					2.27111e-07	2.75778e-07	1	1	0
RCC1	1104	broad.mit.edu	37	1	28861843	28861843	+	Silent	SNP	A	A	G			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr1:28861843A>G	ENST00000373833.6	+	9	897	c.612A>G	c.(610-612)ctA>ctG	p.L204L	RCC1_ENST00000429051.1_3'UTR|RCC1_ENST00000373832.1_Silent_p.L204L|RCC1_ENST00000373831.3_Silent_p.L235L|RCC1_ENST00000398958.2_Silent_p.L204L			P18754	RCC1_HUMAN	regulator of chromosome condensation 1	204					cell division|chromosome segregation|G1/S transition of mitotic cell cycle|mitosis|mitotic spindle organization|regulation of mitosis|regulation of S phase of mitotic cell cycle|spindle assembly|viral reproduction	condensed nuclear chromosome|cytoplasm|nuclear chromatin|nuclear membrane|nucleoplasm	histone binding|nucleosomal DNA binding|Ran guanyl-nucleotide exchange factor activity			breast(1)|kidney(2)|large_intestine(6)|lung(4)|ovary(1)	14		Colorectal(325;3.46e-05)|Lung NSC(340;0.000318)|all_lung(284;0.000434)|Renal(390;0.00121)|Breast(348;0.00345)|all_neural(195;0.00989)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0261)|Medulloblastoma(700;0.123)		Colorectal(126;2.96e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|STAD - Stomach adenocarcinoma(196;0.00299)|KIRC - Kidney renal clear cell carcinoma(1967;0.0101)|BRCA - Breast invasive adenocarcinoma(304;0.022)|READ - Rectum adenocarcinoma(331;0.0649)		AGGGCCAGCTAGGCCGTGTGC	0.587000													16	63					0	0	1	0	0
PEG3	5178	broad.mit.edu	37	19	57334188	57334188	+	Missense_Mutation	SNP	G	G	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr19:57334188G>T	ENST00000326441.9	-	6	861	c.498C>A	c.(496-498)gaC>gaA	p.D166E	PEG3_ENST00000598410.1_Missense_Mutation_p.D41E|ZIM2_ENST00000601070.1_Missense_Mutation_p.D41E|PEG3_ENST00000593695.1_Missense_Mutation_p.D40E|PEG3_ENST00000423103.2_Missense_Mutation_p.D166E|ZIM2_ENST00000391708.3_Missense_Mutation_p.D41E|ZIM2_ENST00000599935.1_Missense_Mutation_p.D41E|ZIM2_ENST00000221722.5_Missense_Mutation_p.D41E|ZIM2_ENST00000593711.1_Missense_Mutation_p.D41E|ZIM2_ENST00000593931.1_Missense_Mutation_p.D41E	NM_006210.2	NP_006201.1	Q9GZU2	PEG3_HUMAN	paternally expressed 3	166					apoptosis|viral reproduction	cytoplasm|nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|biliary_tract(4)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(27)|lung(84)|ovary(8)|pancreas(5)|prostate(6)|skin(8)|stomach(2)|upper_aerodigestive_tract(6)	170		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0269)		TGCCCCTCCGGTCCCAGTCCC	0.542000													10	10					4.68919e-08	5.86e-08	1	1	0
HFM1	164045	broad.mit.edu	37	1	91781454	91781454	+	Missense_Mutation	SNP	T	T	C			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr1:91781454T>C	ENST00000370425.3	-	28	3156	c.3058A>G	c.(3058-3060)Aaa>Gaa	p.K1020E	HFM1_ENST00000294696.5_Missense_Mutation_p.K252E|HFM1_ENST00000462405.1_5'UTR|HFM1_ENST00000370424.3_Missense_Mutation_p.K699E	NM_001017975.3	NP_001017975.3	A2PYH4	HFM1_HUMAN	HFM1, ATP-dependent DNA helicase homolog (S. cerevisiae)	1020	SEC63.						ATP binding|ATP-dependent helicase activity|nucleic acid binding			breast(4)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(17)|lung(33)|ovary(1)|prostate(3)|skin(2)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	75		all_lung(203;0.00961)|Lung NSC(277;0.0351)		all cancers(265;0.000481)|Epithelial(280;0.00863)|OV - Ovarian serous cystadenocarcinoma(397;0.126)|KIRC - Kidney renal clear cell carcinoma(1967;0.171)		GCTGTTCTTTTAGTTTGTAGC	0.313000													25	28					0	0	1	0	0
TMTC1	83857	broad.mit.edu	37	12	29671540	29671540	+	Splice_Site	SNP	C	C	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr12:29671540C>A	ENST00000256062.5	-	13	2038	c.1564_splice	c.e13-1	p.G522_splice	TMTC1_ENST00000552618.1_Splice_Site_p.G654_splice|TMTC1_ENST00000539277.1_Splice_Site_p.G630_splice|TMTC1_ENST00000551659.1_Splice_Site_p.G692_splice|TMTC1_ENST00000319685.8_5'UTR	NM_175861.3	NP_787057.2	Q8IUR5	TMTC1_HUMAN	transmembrane and tetratricopeptide repeat containing 1	630						integral to membrane	binding			breast(1)|endometrium(4)|kidney(3)|large_intestine(17)|lung(45)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	75	Lung NSC(12;7.61e-10)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.032)					TTCTGGTAAGCCTGTAACCAG	0.433000													58	142					6.3237e-29	9.65196e-29	1	1	0
PCYOX1	51449	broad.mit.edu	37	2	70502790	70502790	+	Missense_Mutation	SNP	A	A	G			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr2:70502790A>G	ENST00000433351.2	+	5	879	c.851A>G	c.(850-852)aAg>aGg	p.K284R	PCYOX1_ENST00000505044.2_Missense_Mutation_p.K207R|PCYOX1_ENST00000545138.1_Missense_Mutation_p.K206R|PCYOX1_ENST00000264441.5_Missense_Mutation_p.K284R	NM_016297.3	NP_057381.3	Q9UHG3	PCYOX_HUMAN	prenylcysteine oxidase 1	284					prenylated protein catabolic process	lysosome|very-low-density lipoprotein particle	prenylcysteine oxidase activity			breast(1)|central_nervous_system(3)|endometrium(1)|kidney(1)|large_intestine(3)|lung(6)	15						ACAAAGACCAAGTACACAGGT	0.413000													13	67					0	0	1	0	0
PKHD1	5314	broad.mit.edu	37	6	51900449	51900449	+	Silent	SNP	C	C	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr6:51900449C>A	ENST00000371117.3	-	28	3443	c.3168G>T	c.(3166-3168)tcG>tcT	p.S1056S	PKHD1_ENST00000340994.4_Silent_p.S1056S	NM_138694.3	NP_619639.3	P08F94	PKHD1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)	1056	IPT/TIG 5.				cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			NS(1)|autonomic_ganglia(1)|breast(8)|central_nervous_system(5)|cervix(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(4)|kidney(11)|large_intestine(59)|lung(139)|ovary(16)|prostate(8)|skin(20)|soft_tissue(1)|stomach(2)|upper_aerodigestive_tract(7)|urinary_tract(5)	304	Lung NSC(77;0.0605)					TGATGGCACACGAGTAAGATC	0.453000													36	89					9.8876e-21	1.46825e-20	1	1	0
CHD6	84181	broad.mit.edu	37	20	40049640	40049640	+	Missense_Mutation	SNP	C	C	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr20:40049640C>A	ENST00000373233.3	-	31	5812	c.5635G>T	c.(5635-5637)Gcc>Tcc	p.A1879S		NM_032221.3	NP_115597.3	Q8TD26	CHD6_HUMAN	chromodomain helicase DNA binding protein 6	1879					chromatin remodeling|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding			breast(8)|central_nervous_system(2)|cervix(2)|endometrium(5)|kidney(4)|large_intestine(24)|lung(53)|ovary(8)|prostate(5)|skin(8)|stomach(1)|urinary_tract(9)	129		Myeloproliferative disorder(115;0.00425)				ACTGCCATGGCTAAgttttcc	0.438000													34	65					1.62565e-12	2.22007e-12	1	1	0
MIR891B	100126304	broad.mit.edu	37	X	145082581	145082581	+	RNA	SNP	C	C	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chrX:145082581C>A	ENST00000401245.1	-	0	68					NR_030590.1																						tcttttgaccctaacaacaaa	0.398000													12	18					1.61879e-10	2.12817e-10	1	1	0
SAP130	79595	broad.mit.edu	37	2	128747167	128747167	+	Missense_Mutation	SNP	T	T	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr2:128747167T>A	ENST00000357702.5	-	13	1960	c.1829A>T	c.(1828-1830)cAg>cTg	p.Q610L	SAP130_ENST00000259235.3_Missense_Mutation_p.Q610L|SAP130_ENST00000259234.6_Missense_Mutation_p.Q584L	NM_001145928.1	NP_001139400.1	Q9H0E3	SP130_HUMAN	Sin3A-associated protein, 130kDa	610					histone H3 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	STAGA complex	transcription coactivator activity			NS(4)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(11)|lung(10)|ovary(2)|prostate(1)|skin(5)|urinary_tract(2)	45	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0771)		CTGAGGCTGCTGAGTACCCAT	0.468000													11	84					0	0	1	0	0
CHKA	1119	broad.mit.edu	37	11	67864551	67864551	+	Missense_Mutation	SNP	T	T	G			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr11:67864551T>G	ENST00000265689.4	-	2	423	c.397A>C	c.(397-399)Aca>Cca	p.T133P	CHKA_ENST00000356135.5_Missense_Mutation_p.T133P	NM_001277.2	NP_001268.2	P35790	CHKA_HUMAN	choline kinase alpha	133					lipid transport|phosphatidylethanolamine biosynthetic process	cytoplasm	ATP binding|choline kinase activity|drug binding|ethanolamine kinase activity|signal transducer activity			central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(5)|ovary(1)|skin(1)	13					Choline(DB00122)	AGGGTGGCTGTGGTGTCAGGT	0.522000													9	45					0	0	1	0	0
TMEM106B	54664	broad.mit.edu	37	7	12263979	12263979	+	Missense_Mutation	SNP	G	G	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr7:12263979G>T	ENST00000396667.2	+	5	731	c.409G>T	c.(409-411)Gtt>Ttt	p.V137F	TMEM106B_ENST00000396668.3_Missense_Mutation_p.V137F	NM_018374.3	NP_060844.2	Q9NUM4	T106B_HUMAN	transmembrane protein 106B	137						integral to membrane				NS(1)|endometrium(8)|large_intestine(2)|lung(7)	18				UCEC - Uterine corpus endometrioid carcinoma (126;0.185)		CAGTTATGATGTTCAGAAGCG	0.343000													16	105					2.62699e-14	3.7003e-14	1	1	0
PITX3	5309	broad.mit.edu	37	10	103990789	103990789	+	Missense_Mutation	SNP	C	C	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr10:103990789C>T	ENST00000370002.3	-	4	544	c.391G>A	c.(391-393)Ggc>Agc	p.G131S	PITX3_ENST00000539804.1_Missense_Mutation_p.G131S	NM_005029.3	NP_005020.1	O75364	PITX3_HUMAN	paired-like homeodomain 3	131					dopaminergic neuron differentiation|lens morphogenesis in camera-type eye|midbrain development|positive regulation of transcription, DNA-dependent	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(1)|large_intestine(2)|lung(2)	5		Colorectal(252;0.00957)		Epithelial(162;4.97e-08)|all cancers(201;8.99e-07)		GCGAAGCTGCCTTTGCATAGC	0.706000													6	13					0	0	1	0	0
AKAP6	9472	broad.mit.edu	37	14	33204922	33204922	+	Missense_Mutation	SNP	G	G	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr14:33204922G>A	ENST00000280979.4	+	11	3376	c.3206G>A	c.(3205-3207)cGt>cAt	p.R1069H	AKAP6_ENST00000557272.1_Missense_Mutation_p.R1069H	NM_004274.4	NP_004265.3	Q13023	AKAP6_HUMAN	A kinase (PRKA) anchor protein 6	1069					protein targeting	calcium channel complex|nuclear membrane|sarcoplasmic reticulum	protein kinase A binding|receptor binding			NS(2)|breast(10)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(25)|lung(42)|ovary(5)|pancreas(2)|prostate(3)|skin(9)|urinary_tract(2)	122	Breast(36;0.0388)|Prostate(35;0.15)		LUAD - Lung adenocarcinoma(48;0.00107)|Lung(238;0.00677)|STAD - Stomach adenocarcinoma(7;0.116)	GBM - Glioblastoma multiforme(265;0.019)		TCGAGTCCACGTGACCTGCTC	0.448000													7	125					0	0	1	0	0
OLFM4	10562	broad.mit.edu	37	13	53624196	53624196	+	Missense_Mutation	SNP	G	G	C			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr13:53624196G>C	ENST00000219022.2	+	5	901	c.823G>C	c.(823-825)Ggt>Cgt	p.G275R		NM_006418.4	NP_006409.3	Q6UX06	OLFM4_HUMAN	olfactomedin 4	275	Olfactomedin-like.				cell adhesion	extracellular space				breast(2)|endometrium(4)|kidney(4)|large_intestine(5)|lung(20)|skin(3)|urinary_tract(1)	39		Breast(56;0.000776)|Lung NSC(96;0.000814)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;3.13e-08)		TGGTGCTTGGGGTAGGGATTA	0.473000													16	57					0	0	1	0	0
ACIN1	22985	broad.mit.edu	37	14	23549259	23549259	+	Missense_Mutation	SNP	T	T	C			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr14:23549259T>C	ENST00000262710.1	-	6	1786	c.1459A>G	c.(1459-1461)Aaa>Gaa	p.K487E	ACIN1_ENST00000605057.1_Missense_Mutation_p.K429E|ACIN1_ENST00000457657.1_Missense_Mutation_p.K447E|ACIN1_ENST00000555053.1_Missense_Mutation_p.K487E	NM_001164814.1|NM_014977.3	NP_001158286.1|NP_055792.1	Q9UKV3	ACINU_HUMAN	apoptotic chromatin condensation inducer 1	487					apoptotic chromosome condensation|erythrocyte differentiation|positive regulation of monocyte differentiation	cytosol	ATPase activity|enzyme binding|nucleic acid binding|nucleotide binding			breast(1)|endometrium(6)|kidney(4)|large_intestine(9)|lung(10)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	37	all_cancers(95;1.36e-05)			GBM - Glioblastoma multiforme(265;0.00816)		GATTCTGCTTTGGTGTCTGAA	0.502000													62	135					0	0	1	0	0
TAF1	6872	broad.mit.edu	37	X	70601699	70601699	+	Silent	SNP	T	T	G			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chrX:70601699T>G	ENST00000449580.1	+	9	1515	c.1464T>G	c.(1462-1464)gcT>gcG	p.A488A	TAF1_ENST00000423759.1_Silent_p.A509A|TAF1_ENST00000373790.4_Silent_p.A488A|TAF1_ENST00000276072.3_Silent_p.A509A			P21675	TAF1_HUMAN	TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa	488					G1 phase of mitotic cell cycle|interspecies interaction between organisms|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription initiation from RNA polymerase II promoter|protein autophosphorylation|regulation of transcription involved in G2/M-phase of mitotic cell cycle|RNA polymerase II transcriptional preinitiation complex assembly|transcription elongation from RNA polymerase II promoter|viral reproduction	MLL1 complex|transcription factor TFIID complex	ATP binding|histone acetyl-lysine binding|histone acetyltransferase activity|p53 binding|protein binding|protein serine/threonine kinase activity|sequence-specific DNA binding|TBP-class protein binding|transcription coactivator activity			breast(13)|central_nervous_system(6)|cervix(1)|endometrium(25)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(16)|lung(34)|ovary(9)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(3)	124	Renal(35;0.156)	all_lung(315;0.000321)				TTTGGGATGCTCAGGCCATGC	0.468000													19	62					0	0	1	0	0
TKTL2	84076	broad.mit.edu	37	4	164394876	164394876	+	Missense_Mutation	SNP	T	T	C			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr4:164394876T>C	ENST00000280605.3	-	1	171	c.11A>G	c.(10-12)aAc>aGc	p.N4S		NM_032136.4	NP_115512.3	Q9H0I9	TKTL2_HUMAN	transketolase-like 2	4						cytoplasm	metal ion binding|transketolase activity			breast(1)|endometrium(4)|kidney(2)|large_intestine(9)|lung(42)|ovary(3)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)	70	all_hematologic(180;0.166)	Prostate(90;0.0959)|all_neural(102;0.223)				CTTGGCGTCGTTGGCCATCAT	0.652000													10	35					0	0	1	0	0
ETFB	2109	broad.mit.edu	37	19	51853647	51853647	+	Splice_Site	SNP	T	T	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr19:51853647T>A	ENST00000354232.4	-	3	3116		c.e3-2		ETFB_ENST00000309244.4_Splice_Site|CTD-2616J11.11_ENST00000600067.1_Splice_Site|CTD-2616J11.9_ENST00000600974.1_RNA	NM_001014763.1	NP_001014763.1	P38117	ETFB_HUMAN	electron-transfer-flavoprotein, beta polypeptide						respiratory electron transport chain|transport	mitochondrial matrix	electron carrier activity			kidney(2)|large_intestine(1)|lung(3)	6		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000226)|OV - Ovarian serous cystadenocarcinoma(262;0.00661)		atcgatggcctgaatggggag	0.512000													2	7					0	0	1	0	0
MYT1L	23040	broad.mit.edu	37	2	1926197	1926197	+	Missense_Mutation	SNP	C	C	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr2:1926197C>T	ENST00000399161.2	-	10	2091	c.1344G>A	c.(1342-1344)atG>atA	p.M448I	MYT1L_ENST00000428368.2_Missense_Mutation_p.M448I	NM_015025.2	NP_055840.2	Q9UL68	MYT1L_HUMAN	myelin transcription factor 1-like	448					cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(6)|large_intestine(16)|lung(50)|ovary(5)|prostate(2)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	97	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.037)|all_epithelial(98;0.241)		OV - Ovarian serous cystadenocarcinoma(76;0.169)|all cancers(51;0.244)		TCTTCTCCCTCATGGCCTTTG	0.532000													17	132					0	0	1	0	0
KRT10	3858	broad.mit.edu	37	17	38978810	38978810	+	Missense_Mutation	SNP	G	G	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr17:38978810G>T	ENST00000269576.5	-	1	37	c.28C>A	c.(28-30)Cac>Aac	p.H10N	TMEM99_ENST00000496847.1_Intron|TMEM99_ENST00000301665.3_Intron	NM_000421.3	NP_000412.3	P13645	K1C10_HUMAN	keratin 10	10	Head.			KHY -> SKQF (in Ref. 1; AAA60544).	epidermis development		protein binding|structural constituent of epidermis			NS(2)|kidney(1)|large_intestine(3)|lung(4)|prostate(1)	11		Breast(137;0.000301)				GAAGAGTAGTGCTTGCTTGAG	0.532000													5	43					0.014758	0.0152052	1	1	0
RRP9	9136	broad.mit.edu	37	3	51969674	51969674	+	Missense_Mutation	SNP	T	T	C			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr3:51969674T>C	ENST00000232888.6	-	9	843	c.770A>G	c.(769-771)tAc>tGc	p.Y257C		NM_004704.3	NP_004695.1	O43818	U3IP2_HUMAN	ribosomal RNA processing 9, small subunit (SSU) processome component, homolog (yeast)	257					rRNA processing	nucleolus|small nuclear ribonucleoprotein complex|small nucleolar ribonucleoprotein complex	RNA binding			breast(3)|endometrium(1)|kidney(1)|large_intestine(7)|liver(1)|lung(6)|ovary(1)|skin(1)	21				BRCA - Breast invasive adenocarcinoma(193;8.04e-05)|Kidney(197;0.000553)|KIRC - Kidney renal clear cell carcinoma(197;0.000724)		GGATGTGCTGTAGAGCTGGTG	0.607000													4	46					0	0	1	0	0
SCUBE1	80274	broad.mit.edu	37	22	43617207	43617207	+	Silent	SNP	T	T	C			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr22:43617207T>C	ENST00000360835.3	-	13	1647	c.1521A>G	c.(1519-1521)gcA>gcG	p.A507A		NM_173050.3	NP_766638.2	Q8IWY4	SCUB1_HUMAN	signal peptide, CUB domain, EGF-like 1	507					adult heart development|blood coagulation|endothelial cell differentiation|inflammatory response|post-embryonic development|protein homooligomerization	external side of plasma membrane|extracellular space|extrinsic to plasma membrane	calcium ion binding|identical protein binding|protein heterodimerization activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(2)|endometrium(2)|kidney(4)|large_intestine(4)|lung(11)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	31		all_neural(38;0.0414)|Ovarian(80;0.07)				CGGTCTCCTTTGCTCGTGCCT	0.657000													5	36					0	0	1	0	0
SLITRK3	22865	broad.mit.edu	37	3	164906114	164906114	+	Missense_Mutation	SNP	G	G	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr3:164906114G>T	ENST00000475390.1	-	2	2948	c.2505C>A	c.(2503-2505)caC>caA	p.H835Q	SLITRK3_ENST00000241274.3_Missense_Mutation_p.H835Q			O94933	SLIK3_HUMAN	SLIT and NTRK-like family, member 3	835						integral to membrane				NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(14)|lung(66)|ovary(6)|pancreas(1)|prostate(4)|skin(5)|upper_aerodigestive_tract(5)	119						GAGGGTGATGGTGATTCACCG	0.552000										HNSCC(40;0.11)			22	143					5.26018e-13	7.27424e-13	1	1	0
ZNF628	89887	broad.mit.edu	37	19	55995147	55995147	+	Missense_Mutation	SNP	A	A	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr19:55995147A>T	ENST00000598519.1	+	3	3140	c.2587A>T	c.(2587-2589)Acc>Tcc	p.T863S	ZNF628_ENST00000391718.2_Missense_Mutation_p.T859S	NM_033113.2	NP_149104.3	Q5EBL2	ZN628_HUMAN	zinc finger protein 628	859						nucleus	DNA binding|zinc ion binding			endometrium(4)|kidney(1)|lung(2)	7	Breast(117;0.155)		BRCA - Breast invasive adenocarcinoma(297;0.18)|LUSC - Lung squamous cell carcinoma(43;0.193)	GBM - Glioblastoma multiforme(193;0.0531)		ACAGGAGGTGACCACGGTCCA	0.652000													7	33					0	0	1	0	0
KIF5A	3798	broad.mit.edu	37	12	57963140	57963140	+	Silent	SNP	C	C	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr12:57963140C>T	ENST00000455537.2	+	10	1195	c.921C>T	c.(919-921)tcC>tcT	p.S307S	KIF5A_ENST00000286452.5_Silent_p.S218S	NM_004984.2	NP_004975.2	Q12840	KIF5A_HUMAN	kinesin family member 5A	307	Kinesin-motor.|Microtubule-binding.				blood coagulation|cell death|microtubule-based movement|synaptic transmission	cytosol|kinesin complex|membrane fraction|microtubule|perinuclear region of cytoplasm	ATP binding|microtubule motor activity			breast(2)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(11)|liver(1)|lung(32)|ovary(2)|prostate(2)|skin(2)	62						GCTCACCATCCAGTTATAATG	0.532000													16	134					0	0	1	0	0
KCNH7	90134	broad.mit.edu	37	2	163393468	163393468	+	Missense_Mutation	SNP	C	C	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr2:163393468C>A	ENST00000332142.5	-	3	529	c.430G>T	c.(430-432)Gta>Tta	p.V144L	KCNH7_ENST00000328032.4_Missense_Mutation_p.V144L	NM_033272.3	NP_150375.2	Q9NS40	KCNH7_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 7	144	PAC.				regulation of transcription, DNA-dependent	integral to membrane	protein binding|signal transducer activity			NS(1)|biliary_tract(1)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(22)|lung(53)|ovary(3)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(3)	108					Ibutilide(DB00308)	ATTGGGTTTACCCTCTCTGGG	0.378000													13	113					0.000308642	0.000336266	1	1	0
ICAM5	7087	broad.mit.edu	37	19	10405196	10405196	+	Missense_Mutation	SNP	C	C	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr19:10405196C>T	ENST00000221980.4	+	9	2173	c.2110C>T	c.(2110-2112)Cgg>Tgg	p.R704W		NM_003259.3	NP_003250.3	Q9UMF0	ICAM5_HUMAN	intercellular adhesion molecule 5, telencephalin	704	Ig-like C2-type 8.				cell-cell adhesion	integral to plasma membrane				breast(3)|endometrium(2)|kidney(1)|large_intestine(4)|lung(8)|prostate(2)|upper_aerodigestive_tract(1)	21			OV - Ovarian serous cystadenocarcinoma(20;2.64e-09)|Epithelial(33;4.31e-06)|all cancers(31;9.75e-06)			GCGCTGCTCTCGGGAAGGCAT	0.687000													10	60					0	0	1	0	0
LGALS9	3965	broad.mit.edu	37	17	25967683	25967683	+	Missense_Mutation	SNP	G	G	C			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr17:25967683G>C	ENST00000395473.2	+	3	1685	c.217G>C	c.(217-219)Gtg>Ctg	p.V73L	LGALS9_ENST00000413914.2_Missense_Mutation_p.V16L|LGALS9_ENST00000448970.2_3'UTR|LGALS9_ENST00000310394.5_Missense_Mutation_p.V73L|LGALS9_ENST00000313648.6_Missense_Mutation_p.V73L|LGALS9_ENST00000302228.5_Missense_Mutation_p.V73L|AC015688.3_ENST00000584605.1_3'UTR	NM_009587.2	NP_033665.1	O00182	LEG9_HUMAN	lectin, galactoside-binding, soluble, 9	73	Galectin 1.				positive regulation of I-kappaB kinase/NF-kappaB cascade	cytoplasm|extracellular region	galactose binding|signal transducer activity			endometrium(3)|large_intestine(2)|lung(12)|skin(1)	18	Lung NSC(42;0.0103)		BRCA - Breast invasive adenocarcinoma(3;0.0141)	UCEC - Uterine corpus endometrioid carcinoma (53;0.155)		AGGGTACGTGGTGTGCAACAC	0.547000													21	112					0	0	1	0	0
PAIP1	10605	broad.mit.edu	37	5	43543193	43543193	+	Missense_Mutation	SNP	T	T	C			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr5:43543193T>C	ENST00000306846.3	-	4	879	c.647A>G	c.(646-648)tAt>tGt	p.Y216C	PAIP1_ENST00000338972.4_Missense_Mutation_p.Y104C|PAIP1_ENST00000514514.1_Missense_Mutation_p.Y137C|PAIP1_ENST00000436644.2_Missense_Mutation_p.Y137C	NM_006451.4|NM_182789.3	NP_006442.2|NP_877590.1	Q9H074	PAIP1_HUMAN	poly(A) binding protein interacting protein 1	216	MIF4G.				mRNA stabilization|nuclear-transcribed mRNA poly(A) tail shortening|translational initiation	cytosol	protein binding|RNA binding|translation activator activity			endometrium(2)|kidney(3)|large_intestine(5)|lung(10)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	24	Lung NSC(6;2.07e-05)					AGCTCCCATATAAGAGAAATT	0.373000													61	61					0	0	1	0	0
EPHA3	2042	broad.mit.edu	37	3	89498398	89498398	+	Missense_Mutation	SNP	G	G	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr3:89498398G>T	ENST00000336596.2	+	14	2595	c.2370G>T	c.(2368-2370)tgG>tgT	p.W790C	EPHA3_ENST00000494014.1_Missense_Mutation_p.W790C	NM_005233.5	NP_005224.2	P29320	EPHA3_HUMAN	EPH receptor A3	790	Protein kinase.					extracellular region|integral to plasma membrane	ATP binding			NS(1)|breast(4)|central_nervous_system(4)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(26)|liver(3)|lung(67)|ovary(7)|pancreas(1)|prostate(4)|skin(8)|stomach(1)|upper_aerodigestive_tract(5)	139	all_cancers(8;0.0406)|Melanoma(1;0.00142)|all_epithelial(1;0.0612)	Lung NSC(201;0.0782)		LUSC - Lung squamous cell carcinoma(29;0.00344)|Lung(72;0.00942)		CAATCAGGTGGACATCACCAG	0.418000										TSP Lung(6;0.00050)			11	117					0.000673444	0.0007257	1	1	0
SORCS1	114815	broad.mit.edu	37	10	108337197	108337197	+	Missense_Mutation	SNP	C	C	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr10:108337197C>T	ENST00000263054.6	-	26	3495	c.3488G>A	c.(3487-3489)gGg>gAg	p.G1163E	SORCS1_ENST00000369698.1_3'UTR|SORCS1_ENST00000344440.6_Intron	NM_001206570.1|NM_052918.4	NP_001193499.1|NP_443150.3	Q8WY21	SORC1_HUMAN	sortilin-related VPS10 domain containing receptor 1	1163						integral to membrane	neuropeptide receptor activity|protein binding			breast(5)|central_nervous_system(1)|cervix(2)|endometrium(9)|kidney(2)|large_intestine(24)|lung(69)|ovary(1)|prostate(8)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	127		Breast(234;0.0256)|Colorectal(252;0.09)|Lung NSC(174;0.168)		Epithelial(162;1.66e-05)|all cancers(201;0.000689)		ATACTGTGCCCCAGCAGATCC	0.522000													16	106					0	0	1	0	0
TMEM132A	54972	broad.mit.edu	37	11	60703878	60703878	+	Missense_Mutation	SNP	C	C	G			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr11:60703878C>G	ENST00000005286.4	+	11	2727	c.2574C>G	c.(2572-2574)ttC>ttG	p.F858L	TMEM132A_ENST00000453848.2_Missense_Mutation_p.F857L	NM_017870.3|NM_178031.2	NP_060340.2|NP_821174.1	Q24JP5	T132A_HUMAN	transmembrane protein 132A	857	Binds to HSPA5/GRP78 (By similarity).|Confers cellular localization similar to full-length form (By similarity).					endoplasmic reticulum membrane|Golgi membrane|integral to membrane				breast(1)|cervix(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(14)|ovary(3)|prostate(1)|skin(3)	32						TGGGAGTCTTCTGCGTGGCCA	0.602000													27	166					0	0	1	0	0
PLXNA2	5362	broad.mit.edu	37	1	208252666	208252666	+	Missense_Mutation	SNP	G	G	A	rs143711247	byFrequency	TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr1:208252666G>A	ENST00000367033.3	-	12	3282	c.2525C>T	c.(2524-2526)tCc>tTc	p.S842F		NM_025179.3	NP_079455.3	O75051	PLXA2_HUMAN	plexin A2	842					axon guidance	integral to membrane|intracellular|plasma membrane				NS(1)|breast(3)|central_nervous_system(5)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|liver(1)|lung(28)|ovary(3)|prostate(5)|skin(2)|upper_aerodigestive_tract(3)	80				OV - Ovarian serous cystadenocarcinoma(81;0.199)		CCAGGGGCTGGAAGGGCTGGT	0.622000													4	49					0	0	1	0	0
HSD11B1	3290	broad.mit.edu	37	1	209879210	209879210	+	Missense_Mutation	SNP	G	G	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr1:209879210G>A	ENST00000367028.2	+	3	312	c.143G>A	c.(142-144)aGa>aAa	p.R48K	HSD11B1_ENST00000261465.1_Missense_Mutation_p.R48K|RP1-28O10.1_ENST00000441672.1_RNA|HSD11B1_ENST00000367027.3_Missense_Mutation_p.R48K	NM_001206741.1	NP_001193670.1	P28845	DHI1_HUMAN	hydroxysteroid (11-beta) dehydrogenase 1	48					glucocorticoid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	11-beta-hydroxysteroid dehydrogenase|11-beta-hydroxysteroid dehydrogenase (NADP+) activity|binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(1)|lung(9)	16				OV - Ovarian serous cystadenocarcinoma(81;1.04e-55)|Epithelial(68;1.57e-52)|all cancers(67;1.83e-46)|Colorectal(1306;0.115)	NADH(DB00157)	GGGATCGGAAGAGAGATGGCT	0.517000													21	76					0	0	1	0	0
LILRP2	79166	broad.mit.edu	37	19	55224689	55224689	+	RNA	SNP	G	G	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr19:55224689G>T	ENST00000413439.1	+	0	1861																											TGCTGCTTTAGGATTGGCACA	0.547000													7	16					5.18039e-06	6.03767e-06	1	1	0
GREB1	9687	broad.mit.edu	37	2	11750901	11750901	+	Silent	SNP	G	G	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr2:11750901G>T	ENST00000381486.2	+	18	3054	c.2754G>T	c.(2752-2754)ccG>ccT	p.P918P	GREB1_ENST00000234142.5_Silent_p.P918P	NM_014668.3	NP_055483.2	Q4ZG55	GREB1_HUMAN	growth regulation by estrogen in breast cancer 1	918						integral to membrane				breast(3)|central_nervous_system(2)|endometrium(2)|kidney(4)|large_intestine(9)|lung(9)|ovary(1)	30	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.115)|OV - Ovarian serous cystadenocarcinoma(76;0.186)		GCGGCCTCCCGCAGATGAAGA	0.642000													16	73					6.31663e-08	7.82436e-08	1	1	0
ASTN1	460	broad.mit.edu	37	1	177001821	177001821	+	Missense_Mutation	SNP	G	G	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr1:177001821G>T	ENST00000367654.2	-	3	649	c.636C>A	c.(634-636)caC>caA	p.H212Q	ASTN1_ENST00000281881.3_5'UTR|ASTN1_ENST00000424564.2_Missense_Mutation_p.H212Q|ASTN1_ENST00000361833.2_Missense_Mutation_p.H212Q|ASTN1_ENST00000367657.3_Missense_Mutation_p.H212Q			O14525	ASTN1_HUMAN	astrotactin 1	212					cell migration|neuron cell-cell adhesion	integral to membrane				NS(4)|breast(5)|central_nervous_system(2)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(23)|liver(1)|lung(81)|ovary(6)|prostate(5)|skin(10)|urinary_tract(3)	153						TCTCCCGTCCGTGCCCGCCGA	0.627000													15	93					1.99824e-07	2.43543e-07	1	1	0
FGF13	2258	broad.mit.edu	37	X	137785247	137785247	+	Silent	SNP	G	G	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chrX:137785247G>A	ENST00000315930.6	-	3	962	c.301C>T	c.(301-303)Ctg>Ttg	p.L101L	FGF13_ENST00000370603.3_Silent_p.L111L|FGF13_ENST00000441825.2_Silent_p.L82L|FGF13_ENST00000305414.4_Silent_p.L48L|FGF13_ENST00000541469.1_Silent_p.L55L	NM_004114.3	NP_004105.1	Q92913	FGF13_HUMAN	fibroblast growth factor 13	101					cell-cell signaling|MAPKKK cascade|nervous system development	cytoplasm|nucleus	growth factor activity|protein kinase activator activity			breast(2)|endometrium(3)|kidney(2)|large_intestine(5)|lung(10)|ovary(1)|prostate(1)	24	Acute lymphoblastic leukemia(192;0.000127)					AGGTTAAACAGAGCTGAAATT	0.423000													19	37					0	0	1	0	0
CPOX	1371	broad.mit.edu	37	3	98299601	98299601	+	Missense_Mutation	SNP	G	G	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr3:98299601G>A	ENST00000264193.2	-	7	1509	c.1291C>T	c.(1291-1293)Cat>Tat	p.H431Y		NM_000097.5	NP_000088.3	P36551	HEM6_HUMAN	coproporphyrinogen oxidase	431						mitochondrial intermembrane space	coproporphyrinogen oxidase activity|protein homodimerization activity			endometrium(1)|large_intestine(3)|lung(8)|ovary(1)|prostate(1)|skin(1)|stomach(1)	16						GAGGGTGAATGCATGTACTCC	0.403000													5	60					0	0	1	0	0
MROH9	80133	broad.mit.edu	37	1	170965720	170965720	+	Silent	SNP	G	G	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr1:170965720G>A	ENST00000367759.4	+	14	1564	c.1410G>A	c.(1408-1410)aaG>aaA	p.K470K	MROH9_ENST00000367758.3_Silent_p.K470K	NM_001163629.1	NP_001157101.1			maestro heat-like repeat family member 9																		CTCTAATGAAGGAGAATTTCT	0.438000													14	151					0	0	1	0	0
STIM1	6786	broad.mit.edu	37	11	4104590	4104590	+	Missense_Mutation	SNP	G	G	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr11:4104590G>T	ENST00000300737.4	+	10	1905	c.1336G>T	c.(1336-1338)Ggc>Tgc	p.G446C	STIM1_ENST00000533977.1_Missense_Mutation_p.G273C|STIM1_ENST00000527651.1_Missense_Mutation_p.G446C	NM_003156.3	NP_003147.2	Q13586	STIM1_HUMAN	stromal interaction molecule 1	446					activation of store-operated calcium channel activity|calcium ion transport|detection of calcium ion|platelet activation	integral to endoplasmic reticulum membrane|integral to plasma membrane|microtubule	calcium ion binding|microtubule plus-end binding			haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|liver(1)|lung(14)|pancreas(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	30		Breast(177;0.00159)|Medulloblastoma(188;0.00258)|all_neural(188;0.0233)		BRCA - Breast invasive adenocarcinoma(625;0.114)|LUSC - Lung squamous cell carcinoma(625;0.141)		CAACAACCCTGGCATCCACTC	0.587000													16	59					1.62849e-17	2.35784e-17	1	1	0
CHRNA5	1138	broad.mit.edu	37	15	78885589	78885589	+	Missense_Mutation	SNP	T	T	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr15:78885589T>A	ENST00000299565.5	+	6	1601	c.1401T>A	c.(1399-1401)aaT>aaA	p.N467K	CHRNA3_ENST00000348639.3_Intron|CHRNA5_ENST00000559554.1_3'UTR	NM_000745.3	NP_000736.2	P30532	ACHA5_HUMAN	cholinergic receptor, nicotinic, alpha 5 (neuronal)	467					behavioral response to nicotine	cell junction|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(1)|ovary(1)|prostate(1)|skin(3)	15						GAAATGCAAATAAGTGAAGCC	0.303000													5	22					0	0	1	0	0
LCE2C	353140	broad.mit.edu	37	1	152648786	152648786	+	Missense_Mutation	SNP	G	G	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr1:152648786G>T	ENST00000368783.1	+	2	350	c.295G>T	c.(295-297)Ggc>Tgc	p.G99C	LCE2B_ENST00000417924.2_Intron	NM_178429.2	NP_848516.1	Q5TA81	LCE2C_HUMAN	late cornified envelope 2C	99	Cys-rich.				keratinization					endometrium(2)|large_intestine(2)|lung(6)|ovary(1)|prostate(1)|skin(1)	13	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			ACCTTCTGGGGGCTCTGGCTG	0.647000													21	153					3.8784e-16	5.55829e-16	1	1	0
ASPM	259266	broad.mit.edu	37	1	197073035	197073035	+	Missense_Mutation	SNP	C	C	G			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr1:197073035C>G	ENST00000367409.4	-	18	5602	c.5346G>C	c.(5344-5346)caG>caC	p.Q1782H	ASPM_ENST00000294732.7_Intron|ASPM_ENST00000367408.1_Intron	NM_018136.4	NP_060606.3	Q8IZT6	ASPM_HUMAN	asp (abnormal spindle) homolog, microcephaly associated (Drosophila)	1782	IQ 7.				mitosis	cytoplasm|nucleus	calmodulin binding			breast(6)|central_nervous_system(2)|cervix(2)|endometrium(10)|kidney(9)|large_intestine(28)|liver(1)|lung(87)|ovary(5)|pancreas(2)|prostate(6)|skin(4)|urinary_tract(3)	165						GATAGTAATTCTGAATGACAA	0.358000													21	114					0	0	1	0	0
TTC9C	283237	broad.mit.edu	37	11	62496497	62496497	+	Silent	SNP	C	C	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr11:62496497C>T	ENST00000513247.2	+	2	828	c.576C>T	c.(574-576)ctC>ctT	p.L192L	TTC9C_ENST00000316461.4_Silent_p.L59L|TTC9C_ENST00000532583.1_Silent_p.L59L			Q8N5M4	TTC9C_HUMAN	tetratricopeptide repeat domain 9C	59							binding			breast(1)|endometrium(1)|lung(2)|ovary(1)|pancreas(1)	6						GCCCGGCCCTCACGCCTGAAC	0.532000													11	57					0	0	1	0	0
HELZ	9931	broad.mit.edu	37	17	65156383	65156383	+	Missense_Mutation	SNP	G	G	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr17:65156383G>T	ENST00000358691.5	-	17	2337	c.2171C>A	c.(2170-2172)cCt>cAt	p.P724H	HELZ_ENST00000580168.1_Missense_Mutation_p.P725H	NM_014877.3	NP_055692.2			helicase with zinc finger											NS(1)|breast(5)|endometrium(9)|kidney(3)|large_intestine(11)|liver(1)|lung(24)|ovary(1)|pancreas(1)|prostate(1)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(2)	69	all_cancers(12;1.24e-11)|Breast(2;1.05e-17)|all_epithelial(3;3.87e-13)					ATACCTGAGAGGTCTTGCCTG	0.343000													5	40					0.00116845	0.00124685	1	1	0
FLG2	388698	broad.mit.edu	37	1	152326897	152326897	+	Nonsense_Mutation	SNP	G	G	T	rs147962757		TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr1:152326897G>T	ENST00000388718.5	-	3	3437	c.3365C>A	c.(3364-3366)tCa>tAa	p.S1122*	FLG-AS1_ENST00000445097.1_RNA|FLG-AS1_ENST00000392688.2_RNA	NM_001014342.2	NP_001014364.1	Q5D862	FILA2_HUMAN	filaggrin family member 2	1122	Ser-rich.						calcium ion binding|structural molecule activity			NS(2)|breast(7)|cervix(3)|endometrium(11)|kidney(9)|large_intestine(24)|liver(1)|lung(85)|ovary(12)|pancreas(1)|prostate(6)|skin(17)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(5)	188	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			AGACTGACCTGAGCCCGATCC	0.507000													239	323					3.77748e-100	5.85628e-100	1	1	0
DRD5	1816	broad.mit.edu	37	4	9783976	9783976	+	Missense_Mutation	SNP	C	C	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr4:9783976C>A	ENST00000304374.2	+	1	719	c.323C>A	c.(322-324)cCc>cAc	p.P108H		NM_000798.4	NP_000789.1	P21918	DRD5_HUMAN	dopamine receptor D5	108					activation of adenylate cyclase activity by dopamine receptor signaling pathway|activation of phospholipase C activity by dopamine receptor signaling pathway|cellular calcium ion homeostasis|negative regulation of NAD(P)H oxidase activity|reactive oxygen species metabolic process|synaptic transmission, dopaminergic	integral to plasma membrane				NS(2)|endometrium(8)|kidney(4)|large_intestine(8)|lung(22)|prostate(7)|skin(3)|stomach(2)|urinary_tract(1)	57					Apomorphine(DB00714)|Carphenazine(DB01038)|Fenoldopam(DB00800)|Zuclopenthixol(DB01624)	GGTTACTGGCCCTTTGGAGCG	0.612000													9	54					5.68852e-11	7.60012e-11	1	1	0
SF3B4	10262	broad.mit.edu	37	1	149895781	149895781	+	Missense_Mutation	SNP	G	G	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr1:149895781G>T	ENST00000271628.8	-	5	1623	c.1039C>A	c.(1039-1041)Cct>Act	p.P347T		NM_005850.4	NP_005841.1	Q15427	SF3B4_HUMAN	splicing factor 3b, subunit 4, 49kDa	347						nucleoplasm|U12-type spliceosomal complex	nucleotide binding|protein binding|RNA binding			endometrium(2)|large_intestine(4)|lung(7)|ovary(2)|prostate(1)|skin(1)	17	Breast(34;0.0009)|all_hematologic(923;0.0597)|Hepatocellular(266;0.161)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.221)|STAD - Stomach adenocarcinoma(528;0.247)			CCCATTGGAGGAGGTCCAGGA	0.632000													4	20					0.150653	0.151731	1	1	0
CELSR2	1952	broad.mit.edu	37	1	109795265	109795265	+	Missense_Mutation	SNP	A	A	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr1:109795265A>T	ENST00000271332.3	+	1	2625	c.2564A>T	c.(2563-2565)cAa>cTa	p.Q855L		NM_001408.2	NP_001399.1	Q9HCU4	CELR2_HUMAN	cadherin, EGF LAG seven-pass G-type receptor 2	855	Cadherin 7.				dendrite morphogenesis|homophilic cell adhesion|neural plate anterior/posterior regionalization|neuropeptide signaling pathway|regulation of cell-cell adhesion|regulation of transcription, DNA-dependent|Wnt receptor signaling pathway	cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			NS(1)|autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(14)|lung(27)|ovary(5)|prostate(1)|skin(3)|urinary_tract(2)	82		all_epithelial(167;0.000114)|all_lung(203;0.000321)|Lung NSC(277;0.000626)|Breast(1374;0.244)		Colorectal(144;0.0296)|Lung(183;0.067)|COAD - Colon adenocarcinoma(174;0.114)|Epithelial(280;0.193)|all cancers(265;0.219)		TACACCTTCCAAGGAGGCGAC	0.547000													21	67					0	0	1	0	0
USH2A	7399	broad.mit.edu	37	1	215987204	215987204	+	Missense_Mutation	SNP	G	G	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr1:215987204G>T	ENST00000366943.2	-	49	9999	c.9613C>A	c.(9613-9615)Cgc>Agc	p.R3205S	USH2A_ENST00000307340.3_Missense_Mutation_p.R3205S			O75445	USH2A_HUMAN	Usher syndrome 2A (autosomal recessive, mild)	3205					maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			NS(7)|breast(20)|central_nervous_system(3)|cervix(2)|endometrium(32)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(71)|liver(2)|lung(282)|ovary(25)|pancreas(2)|prostate(12)|skin(22)|stomach(7)|upper_aerodigestive_tract(20)|urinary_tract(3)	527				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		TCACAACAGCGATGTCCAGGC	0.408000										HNSCC(13;0.011)			6	61					5.9392e-07	7.09824e-07	1	1	0
UNC79	57578	broad.mit.edu	37	14	94173139	94173139	+	Missense_Mutation	SNP	G	G	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr14:94173139G>T	ENST00000553484.1	+	51	8017	c.7863G>T	c.(7861-7863)caG>caT	p.Q2621H	UNC79_ENST00000393151.2_Missense_Mutation_p.Q2599H|UNC79_ENST00000555664.1_Missense_Mutation_p.Q2560H|UNC79_ENST00000256339.4_Missense_Mutation_p.Q2422H			Q9P2D8	UNC79_HUMAN	unc-79 homolog (C. elegans)	2599						integral to membrane				breast(3)|cervix(2)|endometrium(10)|kidney(7)|large_intestine(18)|liver(1)|lung(64)|ovary(1)|prostate(5)|skin(3)|urinary_tract(4)	118						GCTCGGGCCAGAGCAGTGCTG	0.577000													27	49					1.17739e-12	1.61237e-12	1	1	0
CES1P1	51716	broad.mit.edu	37	16	55794593	55794593	+	RNA	SNP	T	T	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr16:55794593T>A	ENST00000571348.1	+	0	83					NR_003276.2																						TCTCGCTGCTTCCGCGGCTTG	0.597000													6	49					0	0	1	0	0
CD96	10225	broad.mit.edu	37	3	111297999	111297999	+	Silent	SNP	C	C	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr3:111297999C>T	ENST00000352690.4	+	4	909	c.669C>T	c.(667-669)ttC>ttT	p.F223F	CD96_ENST00000283285.5_Silent_p.F239F|CD96_ENST00000438817.2_Silent_p.F223F	NM_005816.4	NP_005807.1	P40200	TACT_HUMAN	CD96 molecule	239	Ig-like V-type 2.				cell adhesion|immune response|regulation of immune response	integral to plasma membrane				central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(4)|liver(2)|lung(14)|skin(5)	35						TCCAAATCTTCGATGATGGGC	0.438000									Opitz Trigonocephaly syndrome				19	85					0	0	1	0	0
ANK2	287	broad.mit.edu	37	4	114288811	114288811	+	Missense_Mutation	SNP	C	C	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr4:114288811C>T	ENST00000357077.4	+	42	11175	c.11122C>T	c.(11122-11124)Cac>Tac	p.H3708Y	ANK2_ENST00000264366.6_Missense_Mutation_p.H3675Y|ANK2_ENST00000510275.2_Missense_Mutation_p.H275Y|ANK2_ENST00000394537.3_Missense_Mutation_p.H1623Y|ANK2_ENST00000509550.1_Missense_Mutation_p.H799Y|ANK2_ENST00000506722.1_Missense_Mutation_p.H1614Y	NM_001148.4	NP_001139.3	Q01484	ANK2_HUMAN	ankyrin 2, neuronal	3675					axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding			NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(10)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(54)|liver(2)|lung(112)|ovary(8)|pancreas(1)|prostate(7)|skin(11)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(10)	248		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		GACCTGCGATCACCCTCCTAT	0.488000													15	47					0	0	1	0	0
NCKAP5	344148	broad.mit.edu	37	2	133489419	133489419	+	Silent	SNP	G	G	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr2:133489419G>A	ENST00000409261.1	-	17	5707	c.5334C>T	c.(5332-5334)gaC>gaT	p.D1778D	NCKAP5_ENST00000317721.6_Silent_p.D1778D|NCKAP5_ENST00000409213.1_Silent_p.D459D|NCKAP5_ENST00000405974.3_Silent_p.D459D	NM_207363.2	NP_997246.2	O14513	NCKP5_HUMAN	NCK-associated protein 5	1778							protein binding			NS(4)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(29)|lung(51)|prostate(5)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	118						GGCGCTGGCCGTCTGTGGAGG	0.592000													12	82					0	0	1	0	0
OR10A2	341276	broad.mit.edu	37	11	6891795	6891795	+	Silent	SNP	C	C	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr11:6891795C>A	ENST00000307322.4	+	1	872	c.810C>A	c.(808-810)ccC>ccA	p.P270P		NM_001004460.1	NP_001004460.1	Q9H208	O10A2_HUMAN	olfactory receptor, family 10, subfamily A, member 2	270					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.P270P(1)		NS(1)|breast(2)|central_nervous_system(1)|endometrium(3)|large_intestine(4)|lung(12)|urinary_tract(1)	24		Medulloblastoma(188;0.0523)|all_neural(188;0.236)		Epithelial(150;4.89e-08)|BRCA - Breast invasive adenocarcinoma(625;0.13)		TTATGACTCCCATGTTGAACC	0.448000													17	142					1.33834e-09	1.72949e-09	1	1	0
DCHS2	54798	broad.mit.edu	37	4	155287503	155287503	+	Missense_Mutation	SNP	T	T	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr4:155287503T>A	ENST00000357232.3	-	5	552	c.553A>T	c.(553-555)Agc>Tgc	p.S185C	DCHS2_ENST00000339452.1_Missense_Mutation_p.S779C	NM_017639.3	NP_060109.2	Q6V1P9	PCD23_HUMAN	dachsous cadherin-related 2	185	Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(3)|endometrium(8)|kidney(5)|large_intestine(54)|lung(63)|ovary(4)|pancreas(1)|prostate(14)|skin(12)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	176	all_hematologic(180;0.208)	Renal(120;0.0854)		LUSC - Lung squamous cell carcinoma(193;0.107)		TCACTGATGCTCGTCACATAG	0.507000													14	39					0	0	1	0	0
UBA6	55236	broad.mit.edu	37	4	68544212	68544212	+	Missense_Mutation	SNP	C	C	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr4:68544212C>A	ENST00000322244.4	-	5	357	c.298G>T	c.(298-300)Gat>Tat	p.D100Y	UBA6_ENST00000420827.2_Missense_Mutation_p.D100Y	NM_018227.5	NP_060697.4	A0AVT1	UBA6_HUMAN	ubiquitin-like modifier activating enzyme 6	100					protein ubiquitination|ubiquitin-dependent protein catabolic process	cytoplasm	ATP binding|FAT10 activating enzyme activity|ligase activity|protein binding			central_nervous_system(1)|endometrium(5)|kidney(4)|large_intestine(6)|liver(1)|lung(23)|skin(2)|upper_aerodigestive_tract(2)	44						GTTCCTAGATCCCATGCTTGG	0.323000													6	34					0.0215528	0.0220675	1	1	0
CCDC91	55297	broad.mit.edu	37	12	28459817	28459817	+	Missense_Mutation	SNP	A	A	G			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr12:28459817A>G	ENST00000545336.1	+	8	829	c.410A>G	c.(409-411)aAa>aGa	p.K137R	CCDC91_ENST00000539107.1_Missense_Mutation_p.K137R|CCDC91_ENST00000540401.1_3'UTR|CCDC91_ENST00000381259.1_Missense_Mutation_p.K137R|CCDC91_ENST00000381256.1_Missense_Mutation_p.K137R|CCDC91_ENST00000306172.5_Missense_Mutation_p.K107R			Q7Z6B0	CCD91_HUMAN	coiled-coil domain containing 91	137					protein transport	Golgi apparatus|membrane				NS(1)|breast(3)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(8)|skin(1)	22	Acute lymphoblastic leukemia(23;0.00718)|all_hematologic(23;0.0113)|Lung SC(9;0.184)					CTTCAGCAAAAAATTTCAAGT	0.338000													15	44					0	0	1	0	0
ESRRG	2104	broad.mit.edu	37	1	216741360	216741360	+	Missense_Mutation	SNP	G	G	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr1:216741360G>T	ENST00000391890.3	-	6	1118	c.601C>A	c.(601-603)Cct>Act	p.P201T	ESRRG_ENST00000366937.1_Missense_Mutation_p.P229T|ESRRG_ENST00000493748.1_Missense_Mutation_p.P201T|ESRRG_ENST00000360012.3_Missense_Mutation_p.P201T|ESRRG_ENST00000487276.1_Missense_Mutation_p.P201T|ESRRG_ENST00000366940.2_Missense_Mutation_p.P201T|ESRRG_ENST00000361525.3_Missense_Mutation_p.P201T|ESRRG_ENST00000493603.1_Missense_Mutation_p.P201T|ESRRG_ENST00000366938.2_Missense_Mutation_p.P201T|ESRRG_ENST00000359162.2_Missense_Mutation_p.P201T|ESRRG_ENST00000463665.1_Missense_Mutation_p.P162T|ESRRG_ENST00000408911.3_Missense_Mutation_p.P224T|ESRRG_ENST00000361395.2_Missense_Mutation_p.P201T	NM_001243515.1|NM_001243519.1	NP_001230444.1|NP_001230448.1	P62508	ERR3_HUMAN	estrogen-related receptor gamma	224					positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	AF-2 domain binding|retinoic acid receptor activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			endometrium(5)|kidney(1)|large_intestine(8)|liver(1)|lung(29)|ovary(1)|skin(2)|stomach(1)|urinary_tract(1)	49				OV - Ovarian serous cystadenocarcinoma(81;0.0358)|all cancers(67;0.0693)|GBM - Glioblastoma multiforme(131;0.0713)	Diethylstilbestrol(DB00255)	ACCAGCTGAGGGTTCAGGTAT	0.532000													33	87					6.97489e-18	1.01434e-17	1	1	0
RUNX3	864	broad.mit.edu	37	1	25254205	25254205	+	Missense_Mutation	SNP	T	T	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr1:25254205T>A	ENST00000399916.1	-	3	779	c.341A>T	c.(340-342)gAc>gTc	p.D114V	RUNX3_ENST00000308873.6_Missense_Mutation_p.D100V|RUNX3_ENST00000540420.1_Missense_Mutation_p.D7V|RUNX3_ENST00000496967.1_5'UTR|RUNX3_ENST00000338888.3_Missense_Mutation_p.D114V	NM_001031680.2	NP_001026850.1	Q13761	RUNX3_HUMAN	runt-related transcription factor 3	100	Runt.				cell proliferation|induction of apoptosis|negative regulation of cell cycle|negative regulation of epithelial cell proliferation|protein phosphorylation|transcription from RNA polymerase II promoter	cytoplasm|nucleus	ATP binding|DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			endometrium(3)|kidney(2)|large_intestine(4)|lung(4)|ovary(1)|prostate(1)|skin(3)	18		Colorectal(325;3.46e-05)|Renal(390;0.0007)|Lung NSC(340;0.000946)|all_lung(284;0.00131)|Ovarian(437;0.00764)|Breast(348;0.0148)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0936)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0419)|OV - Ovarian serous cystadenocarcinoma(117;2.85e-26)|Colorectal(126;4.35e-08)|COAD - Colon adenocarcinoma(152;1.92e-06)|GBM - Glioblastoma multiforme(114;0.000102)|STAD - Stomach adenocarcinoma(196;0.000766)|KIRC - Kidney renal clear cell carcinoma(1967;0.00148)|BRCA - Breast invasive adenocarcinoma(304;0.00173)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.136)		ATCCGGCACGTCCCCCAATGC	0.632000													42	117					0	0	1	0	0
PCSK2	5126	broad.mit.edu	37	20	17349885	17349885	+	Splice_Site	SNP	G	G	C			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr20:17349885G>C	ENST00000262545.2	+	5	821	c.505_splice	c.e5-1	p.G169_splice	PCSK2_ENST00000377899.1_Splice_Site_p.G150_splice|PCSK2_ENST00000536609.1_Splice_Site_p.G134_splice	NM_002594.3	NP_002585.2	P16519	NEC2_HUMAN	proprotein convertase subtilisin/kexin type 2	169	Catalytic.				enkephalin processing|insulin processing|islet amyloid polypeptide processing	extracellular space|membrane|soluble fraction|transport vesicle	serine-type endopeptidase activity			breast(2)|central_nervous_system(2)|endometrium(5)|kidney(5)|large_intestine(7)|lung(17)|ovary(3)|pancreas(2)|prostate(3)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	53					Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	CTTTTCACAGGGATTGACTAT	0.493000													5	26					0	0	1	0	0
LYPD6B	130576	broad.mit.edu	37	2	150061872	150061872	+	Silent	SNP	A	A	G			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr2:150061872A>G	ENST00000409642.3	+	4	584	c.183A>G	c.(181-183)gcA>gcG	p.A61A	LYPD6B_ENST00000409876.1_Silent_p.A37A|LYPD6B_ENST00000409029.1_Silent_p.A37A|LYPD6B_ENST00000498249.1_3'UTR|LYPD6B_ENST00000280115.7_Silent_p.A61A	NM_177964.3	NP_808879.2	Q8NI32	LPD6B_HUMAN	LY6/PLAUR domain containing 6B	37	UPAR/Ly6.					anchored to membrane|plasma membrane				endometrium(3)|large_intestine(2)|lung(4)|ovary(1)|upper_aerodigestive_tract(1)	11						AAAGCTGGGCATTTGCCAAGA	0.512000													71	195					0	0	1	0	0
TMPRSS11E	28983	broad.mit.edu	37	4	69344567	69344567	+	Splice_Site	SNP	G	G	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr4:69344567G>T	ENST00000305363.4	+	9	1032	c.967_splice	c.e9-1	p.G323_splice		NM_014058.3	NP_054777.2	Q9UL52	TM11E_HUMAN	transmembrane protease, serine 11E	323	Peptidase S1.				proteolysis	extracellular region|integral to plasma membrane	serine-type endopeptidase activity			endometrium(1)|lung(19)|pancreas(1)|skin(3)	24						TTTCTTTTAGGTTACAGTCAA	0.348000													16	115					1.02788e-11	1.38835e-11	1	1	0
TNR	7143	broad.mit.edu	37	1	175375358	175375358	+	Missense_Mutation	SNP	C	C	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr1:175375358C>A	ENST00000367674.1	-	3	1201	c.493G>T	c.(493-495)Gcc>Tcc	p.A165S	TNR_ENST00000263525.2_Missense_Mutation_p.A165S	NM_003285.2	NP_003276.3	Q92752	TENR_HUMAN	tenascin R	165	Cys-rich.				axon guidance|cell adhesion|signal transduction	proteinaceous extracellular matrix				NS(3)|breast(7)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(29)|lung(98)|ovary(4)|pancreas(5)|prostate(4)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	177	Renal(580;0.146)					CTACCTGTGGCAGCACTTTCT	0.612000													36	73					4.65686e-17	6.70316e-17	1	1	0
MROH9	80133	broad.mit.edu	37	1	170965721	170965721	+	Nonsense_Mutation	SNP	G	G	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr1:170965721G>T	ENST00000367759.4	+	14	1565	c.1411G>T	c.(1411-1413)Gag>Tag	p.E471*	MROH9_ENST00000367758.3_Nonsense_Mutation_p.E471*	NM_001163629.1	NP_001157101.1			maestro heat-like repeat family member 9																		TCTAATGAAGGAGAATTTCTG	0.438000													14	149					2.61681e-11	3.52483e-11	1	1	0
CD34	947	broad.mit.edu	37	1	208084357	208084357	+	Silent	SNP	C	C	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr1:208084357C>T	ENST00000356522.4	-	1	390	c.69G>A	c.(67-69)ctG>ctA	p.L23L	CD34_ENST00000537704.1_5'UTR|CD34_ENST00000310833.7_Silent_p.L23L	NM_001773.2	NP_001764.1	P28906	CD34_HUMAN	CD34 molecule	23					cell-cell adhesion|leukocyte migration|regulation of immune response	integral to membrane	carbohydrate binding			kidney(2)|large_intestine(2)|lung(8)|ovary(1)	13						GCAGCAAACTCAGCAAGCAAA	0.711000													3	14					0	0	1	0	0
CCDC41	51134	broad.mit.edu	37	12	94772612	94772612	+	Missense_Mutation	SNP	C	C	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr12:94772612C>A	ENST00000397809.5	-	7	1305	c.756G>T	c.(754-756)caG>caT	p.Q252H	CCDC41_ENST00000549352.1_5'UTR|CCDC41_ENST00000547575.1_Missense_Mutation_p.Q252H|CCDC41_ENST00000339839.5_Missense_Mutation_p.Q252H|CCDC41_ENST00000397807.2_Missense_Mutation_p.Q219H	NM_016122.2	NP_057206.2	Q9Y592	CCD41_HUMAN	coiled-coil domain containing 41	244										breast(1)|central_nervous_system(3)|kidney(3)|large_intestine(8)|lung(8)|prostate(2)|skin(2)	27						ACTGCCGCACCTGTATTCTTT	0.418000													20	125					1.01871e-10	1.34826e-10	1	1	0
FMOD	2331	broad.mit.edu	37	1	203316985	203316985	+	Silent	SNP	G	G	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr1:203316985G>A	ENST00000354955.4	-	2	877	c.414C>T	c.(412-414)ggC>ggT	p.G138G	FMOD_ENST00000464898.1_Intron	NM_002023.4	NP_002014.2	Q06828	FMOD_HUMAN	fibromodulin	138					transforming growth factor beta receptor complex assembly	extracellular space|proteinaceous extracellular matrix				breast(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(4)|ovary(2)|prostate(2)|upper_aerodigestive_tract(2)	17			BRCA - Breast invasive adenocarcinoma(75;0.171)			TGATCTGGTTGCCGTGGAGAG	0.562000													9	75					0	0	1	0	0
MKRN3	7681	broad.mit.edu	37	15	23811043	23811043	+	Silent	SNP	C	C	A	rs143204731		TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr15:23811043C>A	ENST00000314520.3	+	1	590	c.114C>A	c.(112-114)tcC>tcA	p.S38S	MKRN3_ENST00000564592.1_Silent_p.S38S|MKRN3_ENST00000568252.1_Silent_p.S38S	NM_005664.3	NP_005655.1	Q13064	MKRN3_HUMAN	makorin ring finger protein 3	38						ribonucleoprotein complex	ligase activity|nucleic acid binding|zinc ion binding			breast(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(33)|ovary(2)|prostate(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	61		all_cancers(20;8.44e-25)|all_epithelial(15;3.69e-22)|Lung NSC(15;2.96e-18)|all_lung(15;2.8e-17)|Breast(32;0.000353)|Colorectal(260;0.14)		all cancers(64;3.02e-06)|Epithelial(43;1.94e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0012)		GTGAGCCCTCCGGGGAATCTG	0.692000													12	54					6.40141e-05	7.11589e-05	1	1	0
MAP4K3	8491	broad.mit.edu	37	2	39559121	39559121	+	Missense_Mutation	SNP	C	C	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr2:39559121C>A	ENST00000263881.3	-	8	791	c.467G>T	c.(466-468)gGa>gTa	p.G156V	MAP4K3_ENST00000437545.1_Missense_Mutation_p.G93V|MAP4K3_ENST00000341681.5_Missense_Mutation_p.G156V	NM_003618.3	NP_003609.2	Q8IVH8	M4K3_HUMAN	mitogen-activated protein kinase kinase kinase kinase 3	156	Protein kinase.				JNK cascade		ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			NS(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(17)|ovary(4)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	44		all_hematologic(82;0.211)				TGCAGATACTCCAAAATCAGC	0.269000													6	17					0.00307968	0.00324766	1	1	0
RFWD2	64326	broad.mit.edu	37	1	176132971	176132971	+	Missense_Mutation	SNP	C	C	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr1:176132971C>A	ENST00000367669.3	-	4	1136	c.622G>T	c.(622-624)Gac>Tac	p.D208Y	RFWD2_ENST00000308769.8_Missense_Mutation_p.D208Y	NM_022457.5	NP_071902.2	Q8NHY2	RFWD2_HUMAN	ring finger and WD repeat domain 2, E3 ubiquitin protein ligase	208					DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	centrosome|cytosol|focal adhesion|nuclear speck	protein binding|ubiquitin-protein ligase activity|zinc ion binding			endometrium(1)|kidney(2)|large_intestine(5)|lung(17)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	30						ACTGAGTGGTCCAATTTGAAC	0.269000													10	19					7.48243e-07	8.91024e-07	1	1	0
CHD7	55636	broad.mit.edu	37	8	61777757	61777757	+	Missense_Mutation	SNP	G	G	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr8:61777757G>T	ENST00000423902.2	+	38	8738	c.8259G>T	c.(8257-8259)atG>atT	p.M2753I	CHD7_ENST00000524602.1_Missense_Mutation_p.M704I	NM_017780.3	NP_060250.2	Q9P2D1	CHD7_HUMAN	chromodomain helicase DNA binding protein 7	2753					central nervous system development|chromatin modification|cognition|cranial nerve development|face development|heart morphogenesis|in utero embryonic development|inner ear morphogenesis|nose development|palate development|regulation of growth hormone secretion|regulation of transcription, DNA-dependent|retina development in camera-type eye|skeletal system development|T cell differentiation|transcription, DNA-dependent	nucleus	ATP binding|chromatin binding|DNA binding|helicase activity			NS(1)|breast(6)|central_nervous_system(8)|cervix(2)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(16)|lung(49)|ovary(4)|pancreas(2)|prostate(4)|skin(2)|urinary_tract(3)	123		all_cancers(86;0.2)|all_lung(136;0.0402)|Lung NSC(129;0.0459)|all_epithelial(80;0.0477)	BRCA - Breast invasive adenocarcinoma(89;0.143)			TTGCTGGAATGGACCTGACGA	0.627000													5	19					0.000602214	0.000652509	1	1	0
CPED1	79974	broad.mit.edu	37	7	120770217	120770217	+	Missense_Mutation	SNP	G	G	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr7:120770217G>T	ENST00000310396.5	+	12	1913	c.1446G>T	c.(1444-1446)atG>atT	p.M482I	CPED1_ENST00000450913.2_Missense_Mutation_p.M482I|CPED1_ENST00000423795.1_Missense_Mutation_p.M262I	NM_024913.4	NP_079189.4			cadherin-like and PC-esterase domain containing 1																		AGTCACTGATGCATGAATTTT	0.358000													58	94					6.20203e-27	9.39356e-27	1	1	0
CENPF	1063	broad.mit.edu	37	1	214818975	214818975	+	Missense_Mutation	SNP	C	C	G			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr1:214818975C>G	ENST00000366955.3	+	13	6230	c.6062C>G	c.(6061-6063)tCt>tGt	p.S2021C		NM_016343.3	NP_057427.3	P49454	CENPF_HUMAN	centromere protein F, 350/400kDa	2117					cell differentiation|cell division|cell proliferation|DNA replication|G2 phase of mitotic cell cycle|kinetochore assembly|metaphase plate congression|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|muscle organ development|negative regulation of transcription, DNA-dependent|protein transport|regulation of G2/M transition of mitotic cell cycle|regulation of striated muscle tissue development|response to drug	condensed chromosome outer kinetochore|cytosol|midbody|nuclear envelope|nuclear matrix|perinuclear region of cytoplasm|spindle pole	chromatin binding|dynein binding|protein C-terminus binding|protein homodimerization activity|transcription factor binding	p.S2021C(1)		NS(2)|breast(2)|central_nervous_system(4)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(37)|lung(47)|ovary(7)|prostate(3)|skin(6)|stomach(1)|urinary_tract(1)	126				all cancers(67;0.00836)|OV - Ovarian serous cystadenocarcinoma(81;0.00855)|GBM - Glioblastoma multiforme(131;0.0694)|Epithelial(68;0.0833)		ACTTTGTCCTCTGATGTGAGT	0.458000													13	101					0	0	1	0	0
UGT1A4	54657	broad.mit.edu	37	2	234628226	234628226	+	Missense_Mutation	SNP	G	G	C			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr2:234628226G>C	ENST00000373409.3	+	1	803	c.760G>C	c.(760-762)Gtg>Ctg	p.V254L	UGT1A8_ENST00000373450.4_Intron|UGT1A10_ENST00000344644.5_Intron|UGT1A10_ENST00000373445.1_Intron|UGT1A6_ENST00000406651.1_Intron|UGT1A6_ENST00000373424.1_Intron|UGT1A6_ENST00000305139.6_Intron|UGT1A9_ENST00000354728.4_Intron|UGT1A5_ENST00000373414.3_Intron|UGT1A7_ENST00000373426.3_Intron|UGT1A6_ENST00000480628.1_Intron	NM_007120.2	NP_009051.1														autonomic_ganglia(1)|breast(2)|endometrium(3)|kidney(2)|large_intestine(5)|lung(9)|ovary(1)|skin(2)|urinary_tract(1)	26		Breast(86;0.000765)|all_lung(227;0.00266)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0327)|Lung NSC(271;0.0456)|Lung SC(224;0.128)		Epithelial(121;3.49e-18)|BRCA - Breast invasive adenocarcinoma(100;0.000504)|Lung(119;0.0026)|LUSC - Lung squamous cell carcinoma(224;0.00624)		CTATGCATCCGTGTGGCTGTT	0.522000													31	307					0	0	1	0	0
MON2	23041	broad.mit.edu	37	12	62932056	62932056	+	Missense_Mutation	SNP	G	G	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr12:62932056G>A	ENST00000393630.3	+	18	2615	c.2224G>A	c.(2224-2226)Gat>Aat	p.D742N	MON2_ENST00000393632.2_Missense_Mutation_p.D742N|MON2_ENST00000552738.1_Missense_Mutation_p.D719N|MON2_ENST00000546600.1_Missense_Mutation_p.D742N|MON2_ENST00000393629.2_Missense_Mutation_p.D742N|MON2_ENST00000552115.1_Missense_Mutation_p.D742N|MON2_ENST00000280379.6_Missense_Mutation_p.D742N	NM_001278470.1|NM_001278472.1	NP_001265399.1|NP_001265401.1	Q7Z3U7	MON2_HUMAN	MON2 homolog (S. cerevisiae)	742					Golgi to endosome transport|protein transport	cytoplasm	ARF guanyl-nucleotide exchange factor activity|binding			NS(1)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(5)|kidney(3)|large_intestine(15)|lung(21)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	57			BRCA - Breast invasive adenocarcinoma(9;0.218)	GBM - Glioblastoma multiforme(28;0.128)		AGTGATGACAGATTTACCAGT	0.294000													13	73					0	0	1	0	0
RYR2	6262	broad.mit.edu	37	1	237754132	237754132	+	Missense_Mutation	SNP	T	T	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr1:237754132T>A	ENST00000366574.2	+	31	4317	c.4000T>A	c.(4000-4002)Ttg>Atg	p.L1334M	RYR2_ENST00000542537.1_Missense_Mutation_p.L1318M|RYR2_ENST00000360064.6_Missense_Mutation_p.L1332M	NM_001035.2	NP_001026.2	Q92736	RYR2_HUMAN	ryanodine receptor 2 (cardiac)	1334	4 X approximate repeats.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding	p.L1332M(1)		NS(4)|breast(8)|central_nervous_system(11)|cervix(2)|endometrium(39)|haematopoietic_and_lymphoid_tissue(5)|kidney(17)|large_intestine(83)|liver(4)|lung(353)|ovary(18)|pancreas(5)|prostate(12)|skin(8)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(4)	586	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			CAAGAATGACTTGGAAGATTA	0.517000													42	97					0	0	1	0	0
F8	2157	broad.mit.edu	37	X	154221352	154221352	+	Missense_Mutation	SNP	T	T	C			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chrX:154221352T>C	ENST00000360256.4	-	4	660	c.460A>G	c.(460-462)Aca>Gca	p.T154A		NM_000132.3	NP_000123.1	P00451	FA8_HUMAN	coagulation factor VIII, procoagulant component	154	F5/8 type A 1.|Plastocyanin-like 1.				acute-phase response|blood coagulation, intrinsic pathway|cell adhesion|platelet activation|platelet degranulation	extracellular space|plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity|protein binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(27)|liver(1)|lung(47)|ovary(5)|pancreas(3)|prostate(1)|skin(5)|upper_aerodigestive_tract(5)|urinary_tract(2)	120	all_cancers(53;7.19e-17)|all_epithelial(53;9.83e-11)|all_lung(58;6.63e-07)|Lung NSC(58;2.08e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)				Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Drotrecogin alfa(DB00055)	CAGACATATGTATGGCTTCCA	0.433000													72	91					0	0	1	0	0
FRYL	285527	broad.mit.edu	37	4	48583469	48583469	+	Translation_Start_Site	SNP	G	G	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr4:48583469G>A	ENST00000264319.7	-	0	2744				FRYL_ENST00000503238.1_Missense_Mutation_p.R714W|FRYL_ENST00000506685.1_Missense_Mutation_p.R420W|FRYL_ENST00000537810.1_Missense_Mutation_p.R714W|FRYL_ENST00000507711.1_Missense_Mutation_p.R714W|FRYL_ENST00000358350.4_Missense_Mutation_p.R714W			O94915	FRYL_HUMAN	FRY-like						regulation of transcription, DNA-dependent|transcription, DNA-dependent		protein binding	p.R714W(1)		breast(2)|central_nervous_system(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(21)|lung(38)|ovary(1)|pancreas(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	91						AATAAAGCCCGTATTTCTCTA	0.403000													9	55					0	0	1	0	0
ZNF613	79898	broad.mit.edu	37	19	52447483	52447483	+	Missense_Mutation	SNP	G	G	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr19:52447483G>T	ENST00000293471.6	+	6	1026	c.347G>T	c.(346-348)aGg>aTg	p.R116M	ZNF613_ENST00000391794.4_Missense_Mutation_p.R80M	NM_001031721.3	NP_001026891.2	Q6PF04	ZN613_HUMAN	zinc finger protein 613	116					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(3)|lung(8)|ovary(1)|skin(1)|urinary_tract(1)	19		all_neural(266;0.117)		GBM - Glioblastoma multiforme(134;0.00148)|OV - Ovarian serous cystadenocarcinoma(262;0.0183)		ATTCATCAGAGGAAAAGTGAT	0.333000													12	17					2.27111e-07	2.75778e-07	1	1	0
KLHL32	114792	broad.mit.edu	37	6	97533169	97533169	+	Silent	SNP	G	G	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr6:97533169G>A	ENST00000369261.4	+	6	942	c.579G>A	c.(577-579)gtG>gtA	p.V193V	KLHL32_ENST00000536676.1_Silent_p.V157V|KLHL32_ENST00000544166.1_Intron|KLHL32_ENST00000539200.1_Silent_p.V124V	NM_052904.3	NP_443136.2	Q96NJ5	KLH32_HUMAN	kelch-like family member 32	193										breast(2)|endometrium(3)|kidney(4)|large_intestine(9)|lung(13)|ovary(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	38		all_cancers(76;1.19e-06)|Acute lymphoblastic leukemia(125;5.83e-10)|all_hematologic(75;3.67e-07)|all_epithelial(107;0.00778)|Colorectal(196;0.122)		BRCA - Breast invasive adenocarcinoma(108;0.0558)		TTCAGGAGGTGCTGAAGAGCG	0.527000													11	60					0	0	1	0	0
TNC	3371	broad.mit.edu	37	9	117810734	117810734	+	Missense_Mutation	SNP	C	C	G			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr9:117810734C>G	ENST00000350763.4	-	16	5068	c.4657G>C	c.(4657-4659)Gag>Cag	p.E1553Q	TNC_ENST00000423613.2_Intron|TNC_ENST00000542877.1_Intron|TNC_ENST00000535648.1_Intron|TNC_ENST00000341037.4_Intron|TNC_ENST00000340094.3_Missense_Mutation_p.E1189Q|TNC_ENST00000481475.1_5'UTR|TNC_ENST00000346706.3_Intron|TNC_ENST00000345230.3_Intron|TNC_ENST00000537320.1_Intron	NM_002160.3	NP_002151.2	P24821	TENA_HUMAN	tenascin C	1553	Fibronectin type-III 11.				cell adhesion|response to wounding|signal transduction	extracellular space	receptor binding|syndecan binding			NS(3)|breast(5)|central_nervous_system(4)|endometrium(8)|kidney(6)|large_intestine(32)|liver(1)|lung(39)|ovary(1)|pancreas(2)|prostate(5)|skin(5)|stomach(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	120						AAGGCATTCTCCGATGCCATC	0.512000													13	39					0	0	1	0	0
MFRP	83552	broad.mit.edu	37	11	119217190	119217190	+	Nonsense_Mutation	SNP	C	C	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr11:119217190C>A	ENST00000555262.1	-	1	193	c.34G>T	c.(34-36)Gag>Tag	p.E12*	MFRP_ENST00000360167.4_Nonsense_Mutation_p.E12*|MFRP_ENST00000449574.2_Nonsense_Mutation_p.E12*|MFRP_ENST00000530681.1_Nonsense_Mutation_p.E12*|C1QTNF5_ENST00000445041.2_5'UTR|MFRP_ENST00000529147.1_5'UTR	NM_001278431.1	NP_001265360.1			membrane frizzled-related protein											autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(8)|prostate(1)|urinary_tract(1)	18		Medulloblastoma(222;0.0523)|Breast(348;0.174)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;3.84e-05)		TCTGTTGCCTCCATGCAGAGG	0.567000													9	56					3.86212e-05	4.31752e-05	1	1	0
MYO18B	84700	broad.mit.edu	37	22	26164561	26164561	+	Missense_Mutation	SNP	A	A	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr22:26164561A>T	ENST00000335473.7	+	4	928	c.678A>T	c.(676-678)caA>caT	p.Q226H	MYO18B_ENST00000407587.2_Missense_Mutation_p.Q226H|MYO18B_ENST00000536101.1_Missense_Mutation_p.Q226H	NM_032608.5	NP_115997.5	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	226						nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity			NS(2)|breast(6)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(27)|liver(2)|lung(60)|ovary(7)|prostate(8)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(2)	146						ACCCAGGCCAAGGAACTGTGG	0.617000													3	18					0	0	1	0	0
ARNT	405	broad.mit.edu	37	1	150801705	150801705	+	Splice_Site	SNP	T	T	C			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr1:150801705T>C	ENST00000358595.5	-	12	1233		c.e12-2		ARNT_ENST00000515192.1_Splice_Site|ARNT_ENST00000354396.2_Splice_Site|ARNT_ENST00000505755.1_Splice_Site	NM_001197325.1|NM_001668.3|NM_178427.2	NP_001184254.1|NP_001659.1|NP_848514.1	P27540	ARNT_HUMAN	aryl hydrocarbon receptor nuclear translocator						positive regulation of hormone biosynthetic process|positive regulation vascular endothelial growth factor production|regulation of transcription from RNA polymerase II promoter in response to oxidative stress|response to hypoxia		aryl hydrocarbon receptor binding|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription coactivator activity			central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(9)|lung(11)|prostate(2)|skin(4)|stomach(1)	34	all_lung(15;9e-35)|Lung NSC(24;3.45e-31)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.108)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.02)|BRCA - Breast invasive adenocarcinoma(12;0.00606)|LUSC - Lung squamous cell carcinoma(543;0.211)			ACTAGTTACCTGAGAGTGAAG	0.373000			T	ETV6	AML								14	127					0	0	1	0	0
PDE6B	5158	broad.mit.edu	37	4	628498	628498	+	Silent	SNP	C	C	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr4:628498C>A	ENST00000255622.6	+	2	544	c.501C>A	c.(499-501)ctC>ctA	p.L167L	PDE6B_ENST00000496514.1_Silent_p.L167L	NM_000283.3|NM_001145291.1	NP_000274.2|NP_001138763.1	P35913	PDE6B_HUMAN	phosphodiesterase 6B, cGMP-specific, rod, beta	167	GAF 1.				cytosolic calcium ion homeostasis|GMP metabolic process|phototransduction, visible light|platelet activation|visual perception	cytosol|membrane	3',5'-cyclic-GMP phosphodiesterase activity|metal ion binding			NS(1)|breast(3)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(11)|ovary(2)|prostate(2)|urinary_tract(1)	30						CTGACGAGCTCACTGACTACA	0.562000													24	99					2.39556e-15	3.39372e-15	1	1	0
PRPS1L1	221823	broad.mit.edu	37	7	18066953	18066953	+	Silent	SNP	G	G	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr7:18066953G>T	ENST00000506618.2	-	1	533	c.453C>A	c.(451-453)gtC>gtA	p.V151V		NM_175886.2	NP_787082.1	P21108	PRPS3_HUMAN	phosphoribosyl pyrophosphate synthetase 1-like 1	151					nucleoside metabolic process|ribonucleoside monophosphate biosynthetic process		ATP binding|kinase activity|magnesium ion binding|protein homodimerization activity|ribose phosphate diphosphokinase activity			endometrium(1)|kidney(1)|large_intestine(3)|lung(9)|ovary(1)|prostate(3)	18	Lung NSC(10;0.0385)|all_lung(11;0.0736)					TCCACTTCAGGACAGTTGGCT	0.463000													14	117					6.31663e-08	7.82436e-08	1	1	0
ZNF512B	57473	broad.mit.edu	37	20	62599191	62599191	+	Missense_Mutation	SNP	G	G	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr20:62599191G>A	ENST00000450537.1	-	2	173	c.113C>T	c.(112-114)cCg>cTg	p.P38L	ZNF512B_ENST00000369888.1_Missense_Mutation_p.P38L|ZNF512B_ENST00000217130.3_Missense_Mutation_p.P38L			Q96KM6	Z512B_HUMAN	zinc finger protein 512B	38					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|cervix(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(3)|lung(16)|ovary(1)|prostate(4)|skin(1)	33	all_cancers(38;2.14e-11)|all_epithelial(29;3.41e-13)|Lung NSC(23;3.41e-09)|all_lung(23;1.06e-08)					ACCCATCTTCGGTGGGTCATG	0.607000													18	101					0	0	1	0	0
GIGYF1	64599	broad.mit.edu	37	7	100280097	100280097	+	Missense_Mutation	SNP	T	T	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr7:100280097T>A	ENST00000275732.5	-	21	3818	c.2609A>T	c.(2608-2610)tAc>tTc	p.Y870F		NM_022574.4	NP_072096.2	O75420	PERQ1_HUMAN	GRB10 interacting GYF protein 1	870										central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(6)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	23	Lung NSC(181;0.035)|all_lung(186;0.0509)|Esophageal squamous(72;0.0817)					TAGGTGGCTGTATGAGTCACT	0.627000													9	64					0	0	1	0	0
FAAH	2166	broad.mit.edu	37	1	46871941	46871941	+	Silent	SNP	C	C	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr1:46871941C>T	ENST00000243167.8	+	7	936	c.852C>T	c.(850-852)gcC>gcT	p.A284A	FAAH_ENST00000493735.1_3'UTR	NM_001441.2	NP_001432.2	O00519	FAAH1_HUMAN	fatty acid amide hydrolase	284					fatty acid catabolic process	cytoplasm|cytoskeleton|endomembrane system|integral to membrane|organelle membrane	carbon-nitrogen ligase activity, with glutamine as amido-N-donor|fatty acid amide hydrolase activity			breast(3)|endometrium(4)|kidney(2)|large_intestine(3)|lung(7)|ovary(2)|skin(1)	22	Acute lymphoblastic leukemia(166;0.155)				Propofol(DB00818)|Thiopental(DB00599)	GCCCCATGGCCCGGGACGTGG	0.652000											OREG0013458	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	20	120					0	0	1	0	0
ARMS2	387715	broad.mit.edu	37	10	124214313	124214313	+	Missense_Mutation	SNP	C	C	G			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr10:124214313C>G	ENST00000528446.1	+	1	145	c.70C>G	c.(70-72)Ctg>Gtg	p.L24V		NM_001099667.1	NP_001093137.1	P0C7Q2	ARMS2_HUMAN	age-related maculopathy susceptibility 2	24					retina homeostasis	mitochondrion|photoreceptor inner segment				ovary(1)	1		all_neural(114;0.0765)|Lung NSC(174;0.132)|all_lung(145;0.163)|Breast(234;0.238)				GATGGCAAGTCTGTCCTCCTC	0.562000													17	95					0	0	1	0	0
CPNE1	8904	broad.mit.edu	37	20	34214259	34214259	+	Silent	SNP	G	G	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr20:34214259G>T	ENST00000317619.3	-	18	1912	c.1518C>A	c.(1516-1518)ccC>ccA	p.P506P	CPNE1_ENST00000397445.1_Silent_p.P506P|CPNE1_ENST00000397442.1_Silent_p.P450P|CPNE1_ENST00000397446.1_Silent_p.P506P|CPNE1_ENST00000397443.1_Silent_p.P506P|CPNE1_ENST00000352393.4_Silent_p.P506P|CPNE1_ENST00000317677.5_Silent_p.P511P			Q99829	CPNE1_HUMAN	copine I	506					lipid metabolic process|vesicle-mediated transport		calcium-dependent phospholipid binding|phosphatidylserine binding|transporter activity			breast(2)|kidney(2)|large_intestine(6)|lung(4)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	21	Lung NSC(9;0.0053)|all_lung(11;0.00785)		BRCA - Breast invasive adenocarcinoma(18;0.00953)			CCAGTTGTGTGGGCACTTCTG	0.612000													24	174					1.22574e-08	1.55945e-08	1	1	0
HERC2P4	100289574	broad.mit.edu	37	16	32163809	32163809	+	RNA	SNP	G	G	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr16:32163809G>T	ENST00000564145.1	-	0	25																											GGGTGATGGAGCGGAGCTGGG	0.527000													18	90					3.08376e-08	3.88326e-08	1	1	0
ZNF738	148203	broad.mit.edu	37	19	21544571	21544571	+	Missense_Mutation	SNP	G	G	A	rs1142653	by1000genomes	TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr19:21544571G>A	ENST00000311015.3	+	2	218	c.7G>A	c.(7-9)Gac>Aac	p.D3N	ZNF738_ENST00000597810.1_Missense_Mutation_p.D3N|ZNF738_ENST00000594245.1_Missense_Mutation_p.D3N|ZNF738_ENST00000380870.4_Missense_Mutation_p.D3N														p.D3N(1)		kidney(1)|lung(1)	2						CCCATAGGACGACCTGAGGTA	0.453000													4	33					0	0	1	0	0
OPCML	4978	broad.mit.edu	37	11	132306599	132306599	+	Missense_Mutation	SNP	A	A	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr11:132306599A>T	ENST00000331898.7	-	5	1317	c.739T>A	c.(739-741)Tct>Act	p.S247T	OPCML_ENST00000524381.1_Missense_Mutation_p.S240T|OPCML_ENST00000541867.1_Missense_Mutation_p.S247T|OPCML_ENST00000374778.4_Missense_Mutation_p.S206T|OPCML_ENST00000529038.1_5'UTR	NM_002545.3	NP_002536.1	Q14982	OPCM_HUMAN	opioid binding protein/cell adhesion molecule-like	247	Ig-like C2-type 3.				cell adhesion|neuron recognition	anchored to membrane|integral to plasma membrane	opioid receptor activity			endometrium(5)|kidney(1)|large_intestine(12)|lung(17)|ovary(2)|skin(2)|urinary_tract(8)	47	all_hematologic(175;0.019)	all_cancers(12;5.86e-24)|all_epithelial(12;2.65e-17)|all_lung(97;2.89e-05)|Lung NSC(97;6.16e-05)|Breast(109;0.000126)|Medulloblastoma(222;0.0269)|all_neural(223;0.0326)|Esophageal squamous(93;0.129)		all cancers(11;4.61e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.012)		GGGACTGCAGAGGCTTCACAG	0.493000													7	62					0	0	1	0	0
PVRL3	25945	broad.mit.edu	37	3	110845181	110845181	+	Splice_Site	SNP	A	A	G			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr3:110845181A>G	ENST00000485303.1	+	5	1343	c.1069_splice	c.e5+1	p.S356_splice	PVRL3_ENST00000493615.1_Splice_Site_p.S333_splice|PVRL3_ENST00000319792.3_Splice_Site_p.S356_splice	NM_001243286.1|NM_015480.2	NP_001230215.1|NP_056295.1	Q9NQS3	PVRL3_HUMAN	poliovirus receptor-related 3	356					adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane	cell adhesion molecule binding|protein homodimerization activity			breast(1)|cervix(1)|endometrium(1)|kidney(3)|large_intestine(3)|lung(7)|upper_aerodigestive_tract(3)	19						TCTACATTTCAGGTAAGTTAC	0.294000													11	29					0	0	1	0	0
MCOLN3	55283	broad.mit.edu	37	1	85499836	85499836	+	Silent	SNP	T	T	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr1:85499836T>A	ENST00000370587.1	-	5	871	c.495A>T	c.(493-495)cgA>cgT	p.R165R	WDR63_ENST00000370596.1_Intron|MCOLN3_ENST00000370589.2_Silent_p.R165R|MCOLN3_ENST00000341115.4_Silent_p.R109R			Q8TDD5	MCLN3_HUMAN	mucolipin 3	165						integral to membrane	ion channel activity			endometrium(6)|kidney(3)|large_intestine(9)|lung(12)|prostate(3)|skin(1)	34				all cancers(265;0.00957)|Epithelial(280;0.0254)		AGATGTTTCCTCGCTTGTAGA	0.403000													10	170					0	0	1	0	0
CKM	1158	broad.mit.edu	37	19	45811715	45811715	+	Silent	SNP	C	C	G			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr19:45811715C>G	ENST00000221476.3	-	6	903	c.729G>C	c.(727-729)ggG>ggC	p.G243G		NM_001824.4	NP_001815.2	P06732	KCRM_HUMAN	creatine kinase, muscle	243	Phosphagen kinase C-terminal.		G -> A (in dbSNP:rs17875625).		creatine metabolic process	cytosol	ATP binding|creatine kinase activity			cervix(1)|endometrium(1)|large_intestine(8)|lung(3)|prostate(2)|skin(2)	17		Ovarian(192;0.0336)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;2.29e-44)|Epithelial(262;1.05e-38)|GBM - Glioblastoma multiforme(486;3.56e-07)	Creatine(DB00148)	TCATGTTGCCCCCCTTCTCCA	0.577000													28	56					0	0	1	0	0
VPS36	51028	broad.mit.edu	37	13	52991230	52991230	+	Missense_Mutation	SNP	G	G	C			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr13:52991230G>C	ENST00000378060.4	-	12	979	c.952C>G	c.(952-954)Cac>Gac	p.H318D		NM_016075.2	NP_057159.2	Q86VN1	VPS36_HUMAN	vacuolar protein sorting 36 homolog (S. cerevisiae)	318					cellular membrane organization|endosome transport|protein transport|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|late endosome|membrane|nucleus	lipid binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(7)|skin(1)|upper_aerodigestive_tract(2)	17		Breast(56;0.000207)|Lung NSC(96;0.00212)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;3.14e-08)		TCTTCCTTGTGAGACTGAAGC	0.483000													4	42					0	0	1	0	0
TOP3A	7156	broad.mit.edu	37	17	18205211	18205211	+	Missense_Mutation	SNP	C	C	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr17:18205211C>A	ENST00000321105.5	-	8	1117	c.903G>T	c.(901-903)caG>caT	p.Q301H	TOP3A_ENST00000542570.1_Missense_Mutation_p.Q206H	NM_004618.3	NP_004609.1	Q13472	TOP3A_HUMAN	topoisomerase (DNA) III alpha	301					DNA topological change|meiosis	chromosome|PML body	ATP binding|DNA topoisomerase type I activity|protein binding|zinc ion binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(15)|ovary(1)|skin(6)|stomach(2)|urinary_tract(1)	36						CCACACACAACTGATAGAGAA	0.453000													6	15					3.59834e-05	4.04556e-05	1	1	0
ZNF804A	91752	broad.mit.edu	37	2	185801992	185801992	+	Silent	SNP	G	G	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr2:185801992G>A	ENST00000302277.6	+	4	2463	c.1869G>A	c.(1867-1869)gaG>gaA	p.E623E		NM_194250.1	NP_919226.1	Q7Z570	Z804A_HUMAN	zinc finger protein 804A	623						intracellular	zinc ion binding			NS(5)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(22)|liver(2)|lung(79)|ovary(7)|pancreas(1)|prostate(2)|skin(12)|urinary_tract(1)	146						TGGAAGCAGAGAATAGTTACA	0.338000													19	83					0	0	1	0	0
ADSS	159	broad.mit.edu	37	1	244579375	244579375	+	Missense_Mutation	SNP	G	G	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr1:244579375G>A	ENST00000366535.3	-	11	1392	c.1076C>T	c.(1075-1077)gCa>gTa	p.A359V		NM_001126.3	NP_001117.2	P30520	PURA2_HUMAN	adenylosuccinate synthase	359					AMP biosynthetic process|immune system process|purine base metabolic process	cytosol|plasma membrane	adenylosuccinate synthase activity|GTP binding|magnesium ion binding|phosphate binding			endometrium(2)|kidney(1)|large_intestine(3)|lung(1)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	12	all_cancers(71;2.17e-05)|all_epithelial(71;0.00015)|all_neural(11;0.0269)|Breast(184;0.0654)|Glioma(6;0.0724)|Ovarian(71;0.0761)|all_lung(81;0.0874)|Lung NSC(105;0.121)	all_cancers(173;0.0896)|all_epithelial(177;0.172)	all cancers(7;9.71e-08)|GBM - Glioblastoma multiforme(7;1.28e-05)|OV - Ovarian serous cystadenocarcinoma(106;0.0014)		L-Aspartic Acid(DB00128)	CTTGGTAAGTGCCAACCTAAT	0.343000													4	24					0	0	1	0	0
PLXNC1	10154	broad.mit.edu	37	12	94631523	94631523	+	Silent	SNP	C	C	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr12:94631523C>T	ENST00000258526.4	+	10	2313	c.2064C>T	c.(2062-2064)acC>acT	p.T688T		NM_005761.2	NP_005752.1	O60486	PLXC1_HUMAN	plexin C1	688					axon guidance|cell adhesion	integral to membrane|intracellular|plasma membrane	receptor activity|receptor binding			breast(2)|central_nervous_system(1)|cervix(2)|endometrium(4)|kidney(4)|large_intestine(12)|lung(30)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	64						CAAACTTTACCCGGGCATCGA	0.413000													11	35					0	0	1	0	0
WNK1	65125	broad.mit.edu	37	12	970232	970232	+	Silent	SNP	C	C	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr12:970232C>A	ENST00000537687.1	+	7	2317	c.1674C>A	c.(1672-1674)atC>atA	p.I558I	WNK1_ENST00000530271.2_Silent_p.I558I|WNK1_ENST00000315939.6_Silent_p.I558I|WNK1_ENST00000535572.1_Silent_p.I558I|WNK1_ENST00000540360.1_3'UTR|WNK1_ENST00000340908.4_Silent_p.I151I	NM_001184985.1|NM_213655.4	NP_001171914.1|NP_998820.3	Q9H4A3	WNK1_HUMAN	WNK lysine deficient protein kinase 1	558					intracellular protein kinase cascade|ion transport|neuron development	cytoplasm	ATP binding|protein binding|protein kinase inhibitor activity|protein serine/threonine kinase activity			breast(7)|central_nervous_system(1)|endometrium(3)|kidney(6)|large_intestine(15)|lung(43)|ovary(6)|prostate(3)|skin(7)|stomach(8)|upper_aerodigestive_tract(3)|urinary_tract(2)	104	all_cancers(10;0.00611)|all_epithelial(11;0.00825)|all_lung(10;0.0331)|Ovarian(42;0.0512)|Lung NSC(10;0.0632)		Epithelial(1;1.74e-08)|all cancers(1;7.04e-08)|OV - Ovarian serous cystadenocarcinoma(31;0.000423)|BRCA - Breast invasive adenocarcinoma(9;0.0149)|Colorectal(1;0.0197)			CTAAAGCTATCAAAGACAGAG	0.408000													69	175					3.83939e-23	5.74452e-23	1	1	0
SDR42E1	93517	broad.mit.edu	37	16	82033399	82033399	+	Missense_Mutation	SNP	T	T	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr16:82033399T>A	ENST00000328945.5	-	3	626	c.499A>T	c.(499-501)Aat>Tat	p.N167Y	SDR42E1_ENST00000534209.1_5'UTR	NM_145168.2	NP_660151.2	Q8WUS8	D42E1_HUMAN	short chain dehydrogenase/reductase family 42E, member 1	167					steroid biosynthetic process	integral to membrane	3-beta-hydroxy-delta5-steroid dehydrogenase activity|binding			NS(2)|endometrium(1)|lung(4)|skin(3)	10						GGTGTAGCATTCGCCTCCAGC	0.552000													15	107					0	0	1	0	0
CCDC13	152206	broad.mit.edu	37	3	42772081	42772081	+	Splice_Site	SNP	C	C	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr3:42772081C>A	ENST00000310232.6	-	13	1679	c.1595_splice	c.e13-1	p.R532_splice		NM_144719.3	NP_653320.3	Q8IYE1	CCD13_HUMAN	coiled-coil domain containing 13	532										endometrium(1)|kidney(1)|large_intestine(5)|liver(1)|lung(11)|ovary(1)|prostate(3)|skin(1)|urinary_tract(1)	25						AGTCCGAGAACCTGGGACCAG	0.597000													6	38					0.217242	0.218127	1	1	0
TSPAN32	10077	broad.mit.edu	37	11	2337897	2337897	+	Splice_Site	SNP	G	G	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr11:2337897G>A	ENST00000182290.4	+	8	856	c.719_splice	c.e8+1	p.R240_splice	TSPAN32_ENST00000451520.2_Splice_Site_p.R229_splice|TSPAN32_ENST00000381121.3_Splice_Site_p.R240_splice	NM_139022.2	NP_620591.3	Q96QS1	TSN32_HUMAN	tetraspanin 32	240					cell-cell signaling	integral to membrane				breast(1)|central_nervous_system(1)|lung(4)|ovary(1)|skin(1)	8		all_epithelial(84;4.89e-05)|Breast(177;0.000962)|Medulloblastoma(188;0.00106)|Ovarian(85;0.0014)|all_neural(188;0.00791)|Lung NSC(207;0.209)		BRCA - Breast invasive adenocarcinoma(625;0.000533)|LUSC - Lung squamous cell carcinoma(625;0.082)|Lung(200;0.153)		CTGACCCCACGGTAGGGCCCC	0.657000													7	41					0	0	1	0	0
WBSCR17	64409	broad.mit.edu	37	7	71134977	71134977	+	Silent	SNP	T	T	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr7:71134977T>A	ENST00000333538.5	+	8	1921	c.1287T>A	c.(1285-1287)ggT>ggA	p.G429G	WBSCR17_ENST00000498380.2_3'UTR	NM_022479.1	NP_071924.1	Q6IS24	GLTL3_HUMAN	Williams-Beuren syndrome chromosome region 17	429						Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			NS(5)|breast(2)|central_nervous_system(1)|endometrium(7)|kidney(7)|large_intestine(22)|lung(45)|ovary(2)|pancreas(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)	100		all_cancers(73;0.2)|Lung NSC(55;0.094)|all_lung(88;0.125)				TTGACATCGGTGATGTCTCCG	0.453000													13	86					0	0	1	0	0
KTN1	3895	broad.mit.edu	37	14	56139660	56139660	+	Missense_Mutation	SNP	G	G	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr14:56139660G>A	ENST00000416613.1	+	38	3689	c.3617G>A	c.(3616-3618)cGa>cAa	p.R1206Q	KTN1_ENST00000395314.3_Missense_Mutation_p.R1206Q|KTN1_ENST00000555573.1_Missense_Mutation_p.R211Q|KTN1_ENST00000438792.2_Missense_Mutation_p.R1177Q|KTN1_ENST00000554507.1_Missense_Mutation_p.R472Q|KTN1_ENST00000395309.3_Missense_Mutation_p.R1206Q|KTN1_ENST00000395311.1_Missense_Mutation_p.R1183Q|KTN1_ENST00000395308.1_Missense_Mutation_p.R1183Q|KTN1_ENST00000413890.2_Missense_Mutation_p.R1183Q			Q86UP2	KTN1_HUMAN	kinectin 1 (kinesin receptor)	1206					microtubule-based movement	endoplasmic reticulum membrane|integral to plasma membrane|membrane fraction				breast(4)|central_nervous_system(1)|large_intestine(8)|lung(1)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)	19						AGAAGAGAACGAGAACATTTG	0.353000			T	RET	papillary thryoid								9	53					0	0	1	0	0
LPCAT1	79888	broad.mit.edu	37	5	1489874	1489874	+	Missense_Mutation	SNP	C	C	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr5:1489874C>T	ENST00000283415.3	-	4	725	c.593G>A	c.(592-594)gGa>gAa	p.G198E		NM_024830.3	NP_079106.3	Q8NF37	PCAT1_HUMAN	lysophosphatidylcholine acyltransferase 1	198					phospholipid biosynthetic process	endoplasmic reticulum membrane|Golgi membrane|integral to membrane	1-acylglycerophosphocholine O-acyltransferase activity|1-alkylglycerophosphocholine O-acetyltransferase activity|calcium ion binding			breast(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(12)|ovary(4)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	30			OV - Ovarian serous cystadenocarcinoma(19;0.0274)|all cancers(22;0.0534)	GBM - Glioblastoma multiforme(108;0.156)		TGGCCACTTTCCGTTGGACTG	0.517000													57	173					0	0	1	0	0
STIM1	6786	broad.mit.edu	37	11	4104591	4104591	+	Missense_Mutation	SNP	G	G	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr11:4104591G>T	ENST00000300737.4	+	10	1906	c.1337G>T	c.(1336-1338)gGc>gTc	p.G446V	STIM1_ENST00000533977.1_Missense_Mutation_p.G273V|STIM1_ENST00000527651.1_Missense_Mutation_p.G446V	NM_003156.3	NP_003147.2	Q13586	STIM1_HUMAN	stromal interaction molecule 1	446					activation of store-operated calcium channel activity|calcium ion transport|detection of calcium ion|platelet activation	integral to endoplasmic reticulum membrane|integral to plasma membrane|microtubule	calcium ion binding|microtubule plus-end binding			haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|liver(1)|lung(14)|pancreas(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	30		Breast(177;0.00159)|Medulloblastoma(188;0.00258)|all_neural(188;0.0233)		BRCA - Breast invasive adenocarcinoma(625;0.114)|LUSC - Lung squamous cell carcinoma(625;0.141)		AACAACCCTGGCATCCACTCA	0.587000													16	57					1.62849e-17	2.35784e-17	1	1	0
GLYATL1	92292	broad.mit.edu	37	11	58722369	58722369	+	Splice_Site	SNP	G	G	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr11:58722369G>T	ENST00000300079.5	+	5	456	c.406_splice	c.e5+1	p.G136_splice	GLYATL1_ENST00000317391.4_Splice_Site_p.G105_splice|RP11-142C4.6_ENST00000533954.1_RNA	NM_001220496.1|NM_080661.3	NP_001207425.1|NP_542392.2	Q969I3	GLYL1_HUMAN	glycine-N-acyltransferase-like 1	105						mitochondrion	glycine N-acyltransferase activity			NS(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(19)|ovary(1)|skin(4)|urinary_tract(1)	34					Glycine(DB00145)	CCAAATCCAAGGTAACGAGTC	0.388000													10	32					4.68919e-08	5.86e-08	1	1	0
DAPP1	27071	broad.mit.edu	37	4	100756869	100756869	+	Missense_Mutation	SNP	A	A	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr4:100756869A>T	ENST00000296414.7	+	2	272	c.191A>T	c.(190-192)aAt>aTt	p.N64I	DAPP1_ENST00000512369.1_Missense_Mutation_p.N64I			Q9UN19	DAPP1_HUMAN	dual adaptor of phosphotyrosine and 3-phosphoinositides	64	SH2.				signal transduction	cytoplasm|plasma membrane	phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|protein tyrosine phosphatase activity			endometrium(1)|kidney(1)|lung(4)	6				OV - Ovarian serous cystadenocarcinoma(123;7.04e-09)		AGGGACAGCAATGAGACCACC	0.527000													16	72					0	0	1	0	0
AGRN	375790	broad.mit.edu	37	1	985806	985806	+	Splice_Site	SNP	G	G	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr1:985806G>T	ENST00000379370.2	+	29	5026		c.e29-1			NM_198576.3	NP_940978.2	O00468	AGRIN_HUMAN	agrin						axon guidance|clustering of voltage-gated sodium channels|muscarinic acetylcholine receptor signaling pathway|receptor clustering	basal lamina	laminin binding|structural constituent of cytoskeleton			breast(1)|central_nervous_system(2)|endometrium(8)|kidney(3)|large_intestine(2)|lung(20)|ovary(1)|prostate(1)|skin(3)|urinary_tract(1)	42	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		UCEC - Uterine corpus endometrioid carcinoma (11;0.00462)|Epithelial(90;5.98e-38)|OV - Ovarian serous cystadenocarcinoma(86;5.43e-23)|Colorectal(212;5.97e-05)|COAD - Colon adenocarcinoma(227;0.000201)|Kidney(185;0.0024)|BRCA - Breast invasive adenocarcinoma(365;0.00246)|STAD - Stomach adenocarcinoma(132;0.00645)|KIRC - Kidney renal clear cell carcinoma(229;0.0354)|Lung(427;0.201)		CATGACCCCAGGGAGAAGATG	0.687000													5	44					1.23904e-05	1.41892e-05	1	1	0
FOLH1	2346	broad.mit.edu	37	11	49204729	49204729	+	Nonsense_Mutation	SNP	C	C	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr11:49204729C>A	ENST00000340334.7	-	8	1215	c.847G>T	c.(847-849)Gga>Tga	p.G283*	FOLH1_ENST00000356696.3_Nonsense_Mutation_p.G298*|FOLH1_ENST00000533034.1_Nonsense_Mutation_p.G283*|FOLH1_ENST00000256999.2_Nonsense_Mutation_p.G298*|FOLH1_ENST00000343844.4_5'UTR	NM_001193471.1|NM_001193472.1	NP_001180400.1|NP_001180401.1	Q04609	FOLH1_HUMAN	folate hydrolase (prostate-specific membrane antigen) 1	298	NAALADase.				proteolysis	cytoplasm|integral to plasma membrane|membrane fraction|nucleus	carboxypeptidase activity|dipeptidase activity|metal ion binding|metallopeptidase activity			NS(2)|breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(7)|lung(34)|ovary(1)|skin(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	60					Capromab(DB00089)|L-Glutamic Acid(DB00142)	TCATAGTATCCAATTGGATGA	0.358000													9	45					2.17888e-05	2.47794e-05	1	1	0
TET2	54790	broad.mit.edu	37	4	106155994	106155994	+	Missense_Mutation	SNP	G	G	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr4:106155994G>A	ENST00000540549.1	+	3	1755	c.895G>A	c.(895-897)Gat>Aat	p.D299N	TET2_ENST00000545826.1_Missense_Mutation_p.D299N|TET2_ENST00000305737.2_Missense_Mutation_p.D299N|TET2_ENST00000380013.4_Missense_Mutation_p.D299N|TET2_ENST00000394764.1_Missense_Mutation_p.D299N|TET2_ENST00000413648.2_Missense_Mutation_p.D299N|TET2_ENST00000513237.1_Missense_Mutation_p.D320N			Q6N021	TET2_HUMAN	tet methylcytosine dioxygenase 2	299					cell cycle|myeloid cell differentiation		metal ion binding|methylcytosine dioxygenase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			NS(1)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1272)|kidney(3)|large_intestine(11)|lung(10)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	1314		Myeloproliferative disorder(5;0.0393)		OV - Ovarian serous cystadenocarcinoma(123;7.18e-08)		CTGTGATGCTGATGATGCTGA	0.458000			"""Mis N, F"""		MDS								4	44					0	0	1	0	0
ZNF233	353355	broad.mit.edu	37	19	44771144	44771144	+	Missense_Mutation	SNP	G	G	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr19:44771144G>A	ENST00000592581.1	+	4	374	c.268G>A	c.(268-270)Ggg>Agg	p.G90R	ZNF235_ENST00000589799.1_Intron|ZNF233_ENST00000589522.1_Intron|ZNF233_ENST00000391958.2_Intron|ZNF233_ENST00000334152.1_Intron	NM_001207005.1	NP_001193934.1	A6NK53	ZN233_HUMAN	zinc finger protein 233	570					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(4)|skin(3)|urinary_tract(1)	20		Prostate(69;0.0435)|all_neural(266;0.226)				GAGTCTTTGCGGGGTACAGCC	0.532000													13	36					0	0	1	0	0
UBTF	7343	broad.mit.edu	37	17	42293286	42293286	+	Silent	SNP	G	G	C			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr17:42293286G>C	ENST00000302904.4	-	4	798	c.306C>G	c.(304-306)ggC>ggG	p.G102G	UBTF_ENST00000393606.3_Silent_p.G102G|UBTF_ENST00000526094.1_Silent_p.G102G|UBTF_ENST00000436088.1_Silent_p.G102G|UBTF_ENST00000343638.5_Silent_p.G102G|UBTF_ENST00000537550.1_5'UTR|CTB-175E5.7_ENST00000586560.1_RNA|UBTF_ENST00000533177.1_Silent_p.G102G|UBTF_ENST00000527034.1_Silent_p.G102G|UBTF_ENST00000529383.1_Silent_p.G102G			P17480	UBF1_HUMAN	upstream binding transcription factor, RNA polymerase I	102					positive regulation of transcription from RNA polymerase I promoter|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription initiation from RNA polymerase I promoter	nucleolus|nucleoplasm	DNA binding|protein binding			breast(1)|central_nervous_system(2)|endometrium(1)|large_intestine(9)|lung(10)|ovary(1)|prostate(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	29		Breast(137;0.00765)|Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.114)		TGAGTTTTTTGCCTTTGTAAG	0.478000													23	93					0	0	1	0	0
MED13L	23389	broad.mit.edu	37	12	116422079	116422079	+	Silent	SNP	A	A	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr12:116422079A>T	ENST00000281928.3	-	20	4643	c.4437T>A	c.(4435-4437)ctT>ctA	p.L1479L		NM_015335.4	NP_056150.1	Q71F56	MD13L_HUMAN	mediator complex subunit 13-like	1479					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent					NS(2)|breast(1)|endometrium(9)|kidney(3)|large_intestine(18)|lung(34)|ovary(4)|prostate(4)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	85	all_neural(191;0.117)|Medulloblastoma(191;0.163)			BRCA - Breast invasive adenocarcinoma(302;0.0407)		ACTCACTCACAAGCTCATCTG	0.507000													6	37					0	0	1	0	0
LCE2B	26239	broad.mit.edu	37	1	152659357	152659357	+	Missense_Mutation	SNP	C	C	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr1:152659357C>T	ENST00000368780.3	+	2	92	c.38C>T	c.(37-39)cCt>cTt	p.P13L	LCE2B_ENST00000417924.2_Missense_Mutation_p.P13L	NM_014357.4	NP_055172.1	O14633	LCE2B_HUMAN	late cornified envelope 2B	13	Cys-rich.|Pro-rich.				keratinization					endometrium(1)|large_intestine(1)|lung(4)|ovary(1)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	11	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			TGCCAGCCCCCTCCCAAGTGT	0.498000													27	215					0	0	1	0	0
LPAL2	80350	broad.mit.edu	37	6	160906946	160906946	+	RNA	SNP	C	C	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr6:160906946C>T	ENST00000335388.5	-	0	750					NR_028092.1															large_intestine(1)|lung(4)	5		Breast(66;0.000496)|Ovarian(120;0.0303)|Prostate(117;0.214)		OV - Ovarian serous cystadenocarcinoma(65;2.5e-17)|BRCA - Breast invasive adenocarcinoma(81;6.48e-06)		GTATGTGCCTCGATAACTCTG	0.453000													44	221					0	0	1	0	0
TFAM	7019	broad.mit.edu	37	10	60154788	60154788	+	Missense_Mutation	SNP	G	G	C			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr10:60154788G>C	ENST00000487519.1	+	7	1221	c.695G>C	c.(694-696)cGt>cCt	p.R232P	TFAM_ENST00000373895.3_Missense_Mutation_p.R200P|TFAM_ENST00000373899.3_3'UTR	NM_003201.1	NP_003192.1	Q00059	TFAM_HUMAN	transcription factor A, mitochondrial	232					DNA-dependent DNA replication|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase I promoter|transcription initiation from mitochondrial promoter	mitochondrial nucleoid	mitochondrial light strand promoter sense binding|protein binding|sequence-specific DNA binding transcription factor activity			kidney(1)|large_intestine(1)|lung(4)|prostate(1)	7						GATCTTCTACGTCGCACAATA	0.373000													3	26					0	0	1	0	0
ASXL2	55252	broad.mit.edu	37	2	25967024	25967024	+	Missense_Mutation	SNP	T	T	C			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr2:25967024T>C	ENST00000435504.4	-	13	2475	c.2182A>G	c.(2182-2184)Aca>Gca	p.T728A	ASXL2_ENST00000404843.1_Missense_Mutation_p.T468A|ASXL2_ENST00000272341.4_Missense_Mutation_p.T468A|ASXL2_ENST00000336112.4_Missense_Mutation_p.T700A			Q76L83	ASXL2_HUMAN	additional sex combs like 2 (Drosophila)	728	Gly-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|protein binding			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(7)|pancreas(1)|prostate(4)|skin(3)|urinary_tract(3)	33	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					AGTTCCAGTGTGGGGCCCTTT	0.597000													29	163					0	0	1	0	0
RAPGEF4	11069	broad.mit.edu	37	2	173853436	173853436	+	Missense_Mutation	SNP	C	C	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr2:173853436C>A	ENST00000264111.6	+	14	1427	c.1240C>A	c.(1240-1242)Ctg>Atg	p.L414M	RAPGEF4_ENST00000397081.3_Missense_Mutation_p.L415M|RAPGEF4_ENST00000397087.3_Missense_Mutation_p.L271M|RAPGEF4_ENST00000540783.1_Missense_Mutation_p.L262M|RAPGEF4_ENST00000409036.1_Missense_Mutation_p.L415M|RAPGEF4_ENST00000535187.1_Missense_Mutation_p.L195M|RAPGEF4_ENST00000539331.1_Missense_Mutation_p.L262M|RAPGEF4_ENST00000538974.1_Missense_Mutation_p.L244M|RAPGEF4_ENST00000473043.1_3'UTR			Q8WZA2	RPGF4_HUMAN	Rap guanine nucleotide exchange factor (GEF) 4	415					blood coagulation|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|regulation of insulin secretion|regulation of protein phosphorylation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cAMP-dependent protein kinase complex|membrane fraction|plasma membrane	cAMP binding|cAMP-dependent protein kinase regulator activity|Ras GTPase binding|Ras guanyl-nucleotide exchange factor activity			breast(1)|central_nervous_system(2)|endometrium(5)|kidney(5)|large_intestine(14)|lung(13)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	47			OV - Ovarian serous cystadenocarcinoma(117;0.194)			GGTCTGCACCCTGCATGAAGG	0.507000													43	137					1.7489e-18	2.55849e-18	1	1	0
TRABD2A	129293	broad.mit.edu	37	2	85059220	85059220	+	Silent	SNP	G	G	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr2:85059220G>T	ENST00000335459.5	-	4	1099	c.894C>A	c.(892-894)ggC>ggA	p.G298G	TRABD2A_ENST00000409520.2_Silent_p.G347G|TRABD2A_ENST00000479944.1_5'UTR	NM_001080824.1	NP_001074293.1			TraB domain containing 2A																		CTACCTCATAGCCTTCACGCC	0.547000													15	64					1.5739e-10	2.07191e-10	1	1	0
CRTAC1	55118	broad.mit.edu	37	10	99667822	99667822	+	Silent	SNP	G	G	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr10:99667822G>A	ENST00000370597.3	-	6	1153	c.798C>T	c.(796-798)ttC>ttT	p.F266F	CRTAC1_ENST00000370591.2_Silent_p.F266F|CRTAC1_ENST00000298819.4_Silent_p.F266F	NM_018058.6	NP_060528.3	Q9NQ79	CRAC1_HUMAN	cartilage acidic protein 1	266						proteinaceous extracellular matrix	calcium ion binding			autonomic_ganglia(1)|breast(1)|endometrium(6)|kidney(3)|large_intestine(7)|lung(6)|ovary(6)|pancreas(1)|prostate(2)|skin(1)|urinary_tract(1)	35		Colorectal(252;0.24)		Epithelial(162;2.18e-10)|all cancers(201;3.27e-09)		TGTGGAAAAGGAAGTTAGGCC	0.617000													6	48					0	0	1	0	0
KSR1	8844	broad.mit.edu	37	17	25783878	25783878	+	Missense_Mutation	SNP	A	A	C			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr17:25783878A>C	ENST00000319524.6	+	1	209	c.209A>C	c.(208-210)cAg>cCg	p.Q70P	KSR1_ENST00000509603.2_Missense_Mutation_p.Q70P			Q8IVT5	KSR1_HUMAN	kinase suppressor of ras 1	68					Ras protein signal transduction	cytoplasm|membrane	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|large_intestine(5)|lung(12)|prostate(2)|urinary_tract(1)	28	Lung NSC(42;0.00836)		BRCA - Breast invasive adenocarcinoma(3;0.00122)	UCEC - Uterine corpus endometrioid carcinoma (53;0.168)		GACCTCACCCAGCAGGAGATA	0.687000													8	30					0	0	1	0	0
KLHDC10	23008	broad.mit.edu	37	7	129770468	129770468	+	Missense_Mutation	SNP	G	G	C			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr7:129770468G>C	ENST00000335420.5	+	10	1345	c.1211G>C	c.(1210-1212)aGc>aCc	p.S404T		NM_014997.3	NP_055812.1	Q6PID8	KLD10_HUMAN	kelch domain containing 10	404										breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|liver(2)|lung(10)|prostate(1)	17						GTGGTACCTAGCCTGCTGGAA	0.512000													49	145					0	0	1	0	0
ACO2	50	broad.mit.edu	37	22	41924512	41924512	+	Missense_Mutation	SNP	C	C	G			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr22:41924512C>G	ENST00000396512.3	+	18	2330	c.2313C>G	c.(2311-2313)aaC>aaG	p.N771K	POLR3H_ENST00000355209.4_3'UTR|ACO2_ENST00000216254.4_Missense_Mutation_p.N746K|POLR3H_ENST00000396504.2_3'UTR			Q99798	ACON_HUMAN	aconitase 2, mitochondrial	746					citrate metabolic process|tricarboxylic acid cycle	mitochondrial matrix|nucleus	4 iron, 4 sulfur cluster binding|aconitate hydratase activity|citrate hydro-lyase (cis-aconitate-forming) activity|iron ion binding|isocitrate hydro-lyase (cis-aconitate-forming) activity			breast(3)|endometrium(5)|large_intestine(2)|lung(6)|ovary(1)|prostate(1)|skin(2)|stomach(1)|urinary_tract(2)	23						AGCACCCCAACGGGACCCAGG	0.602000													10	46					0	0	1	0	0
SEMA6A	57556	broad.mit.edu	37	5	115827452	115827452	+	Silent	SNP	G	G	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr5:115827452G>A	ENST00000343348.6	-	7	1306	c.519C>T	c.(517-519)aaC>aaT	p.N173N	CTB-118N6.3_ENST00000514214.1_RNA|CTB-118N6.3_ENST00000508640.1_RNA|CTB-118N6.3_ENST00000510682.1_RNA|SEMA6A_ENST00000503962.1_5'UTR|SEMA6A_ENST00000510263.1_Silent_p.N173N|SEMA6A_ENST00000257414.8_Silent_p.N173N	NM_020796.3	NP_065847.1	Q9H2E6	SEM6A_HUMAN	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A	173	Sema.				apoptosis|axon guidance|cell surface receptor linked signaling pathway|cytoskeleton organization|organ morphogenesis	axon|integral to membrane|plasma membrane	receptor activity			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(15)|ovary(2)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	31		all_cancers(142;0.00316)|all_epithelial(76;5.71e-05)|Prostate(80;0.00845)|Ovarian(225;0.0796)|Lung NSC(810;0.171)|all_lung(232;0.203)		OV - Ovarian serous cystadenocarcinoma(64;1.59e-08)|Epithelial(69;2e-08)|all cancers(49;5.7e-08)|COAD - Colon adenocarcinoma(49;0.151)		ACAGTGCAACGTTGGCATGTT	0.438000													11	48					0	0	1	0	0
GLTSCR1L	23506	broad.mit.edu	37	6	42832781	42832781	+	Missense_Mutation	SNP	G	G	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr6:42832781G>T	ENST00000314073.5	+	13	3013	c.2837G>T	c.(2836-2838)aGa>aTa	p.R946I	GLTSCR1L_ENST00000394168.1_Missense_Mutation_p.R946I					GLTSCR1-like																		ACCTCATCCAGATCGGATCAT	0.537000													10	67					7.48243e-07	8.91024e-07	1	1	0
LPHN2	23266	broad.mit.edu	37	1	82415958	82415958	+	Silent	SNP	C	C	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr1:82415958C>T	ENST00000370728.1	+	9	1929	c.1284C>T	c.(1282-1284)ggC>ggT	p.G428G	LPHN2_ENST00000370725.1_Silent_p.G428G|LPHN2_ENST00000394879.1_Silent_p.G428G|LPHN2_ENST00000319517.6_Silent_p.G428G|LPHN2_ENST00000370713.1_Silent_p.G428G|LPHN2_ENST00000335786.5_Silent_p.G428G|LPHN2_ENST00000271029.4_Silent_p.G428G|LPHN2_ENST00000370730.1_Silent_p.G428G|LPHN2_ENST00000370715.1_Silent_p.G428G|LPHN2_ENST00000469377.2_Intron|LPHN2_ENST00000370727.1_Silent_p.G428G|LPHN2_ENST00000370723.1_Silent_p.G428G|LPHN2_ENST00000370721.1_Intron|LPHN2_ENST00000370717.2_Silent_p.G428G|LPHN2_ENST00000359929.3_Silent_p.G428G			O95490	LPHN2_HUMAN	latrophilin 2	428					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|latrotoxin receptor activity|sugar binding			NS(3)|breast(6)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(18)|liver(2)|lung(37)|ovary(3)|pancreas(1)|prostate(3)|skin(22)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(5)	119				all cancers(265;0.00142)|Epithelial(280;0.00829)|OV - Ovarian serous cystadenocarcinoma(397;0.077)|STAD - Stomach adenocarcinoma(256;0.248)		CACAGAAAGGCCCCATGAGCA	0.418000													19	211					0	0	1	0	0
LEMD3	23592	broad.mit.edu	37	12	65639486	65639486	+	Missense_Mutation	SNP	G	G	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr12:65639486G>T	ENST00000308330.2	+	11	2451	c.2425G>T	c.(2425-2427)Gca>Tca	p.A809S		NM_001167614.1|NM_014319.4	NP_001161086.1|NP_055134.2	Q9Y2U8	MAN1_HUMAN	LEM domain containing 3	809	Interaction with SMAD1, SMAD2, SMAD3 and SMAD5.				negative regulation of activin receptor signaling pathway|negative regulation of BMP signaling pathway|negative regulation of transforming growth factor beta receptor signaling pathway	integral to nuclear inner membrane|membrane fraction	DNA binding|nucleotide binding|protein binding			breast(1)|central_nervous_system(4)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(10)|ovary(3)|skin(1)|upper_aerodigestive_tract(2)	36			LUAD - Lung adenocarcinoma(6;0.0234)|LUSC - Lung squamous cell carcinoma(43;0.0975)	GBM - Glioblastoma multiforme(28;0.0104)		AATTCAAGAAGCAATTTTAGA	0.328000													10	69					2.27111e-07	2.75778e-07	1	1	0
EPN1	29924	broad.mit.edu	37	19	56189960	56189960	+	Silent	SNP	G	G	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr19:56189960G>A	ENST00000411543.2	+	3	847	c.300G>A	c.(298-300)ggG>ggA	p.G100G	EPN1_ENST00000270460.6_5'UTR|EPN1_ENST00000085079.7_5'UTR	NM_001130071.1	NP_001123543.1	Q9Y6I3	EPN1_HUMAN	epsin 1	0	ENTH.				endocytosis|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway	coated pit|cytoplasm|nucleus|plasma membrane	lipid binding			endometrium(5)|kidney(1)|large_intestine(2)|lung(8)|skin(1)	17		Colorectal(82;0.00244)|Ovarian(87;0.133)		GBM - Glioblastoma multiforme(193;0.112)		CACGCATCGGGGCCCTGTGCC	0.627000													8	10					0	0	1	0	0
MYOM2	9172	broad.mit.edu	37	8	2088646	2088646	+	Splice_Site	SNP	A	A	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr8:2088646A>T	ENST00000262113.4	+	33	3942	c.3800_splice	c.e33-1	p.K1267_splice	MYOM2_ENST00000523438.1_Splice_Site_p.K692_splice	NM_003970.2	NP_003961.2	P54296	MYOM2_HUMAN	myomesin 2	1267					muscle contraction	myosin filament	structural constituent of muscle			autonomic_ganglia(2)|breast(4)|central_nervous_system(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(11)|kidney(2)|large_intestine(17)|lung(39)|ovary(5)|prostate(1)|skin(10)|upper_aerodigestive_tract(3)	104		Ovarian(12;0.0572)|Colorectal(14;0.0844)|Hepatocellular(245;0.217)		BRCA - Breast invasive adenocarcinoma(11;1.85e-05)|Colorectal(4;0.0101)|READ - Rectum adenocarcinoma(4;0.148)|COAD - Colon adenocarcinoma(4;0.179)		TCTTTTCAAGAGATGCTAAGA	0.478000													7	55					0	0	1	0	0
CENPE	1062	broad.mit.edu	37	4	104082500	104082500	+	Nonsense_Mutation	SNP	C	C	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr4:104082500C>A	ENST00000265148.3	-	19	2046	c.1957G>T	c.(1957-1959)Gag>Tag	p.E653*	CENPE_ENST00000380026.3_Nonsense_Mutation_p.E628*	NM_001813.2	NP_001804.2	Q02224	CENPE_HUMAN	centromere protein E, 312kDa	653					blood coagulation|cell division|kinetochore assembly|microtubule-based movement|mitotic chromosome movement towards spindle pole|mitotic metaphase|mitotic metaphase plate congression|mitotic prometaphase|multicellular organismal development|positive regulation of protein kinase activity	condensed chromosome kinetochore|cytosol|microtubule|nucleus|spindle	ATP binding|kinetochore binding|microtubule motor activity			NS(3)|breast(6)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(20)|lung(34)|ovary(5)|pancreas(1)|prostate(2)|skin(3)|stomach(5)|urinary_tract(3)	101				OV - Ovarian serous cystadenocarcinoma(123;2.95e-08)		ACCATTTTCTCCTTCAGCTCC	0.333000													11	59					1.08611e-07	1.33197e-07	1	1	0
LIG4	3981	broad.mit.edu	37	13	108862093	108862093	+	Silent	SNP	A	A	G			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr13:108862093A>G	ENST00000356922.4	-	2	1796	c.1524T>C	c.(1522-1524)tcT>tcC	p.S508S	LIG4_ENST00000405925.1_Silent_p.S508S|LIG4_ENST00000442234.1_Silent_p.S508S	NM_002312.3|NM_206937.1	NP_002303.2|NP_996820.1	P49917	DNLI4_HUMAN	ligase IV, DNA, ATP-dependent	508					cell cycle|cell division|cell proliferation|central nervous system development|chromosome organization|DNA ligation involved in DNA recombination|DNA ligation involved in DNA repair|DNA replication|double-strand break repair via nonhomologous end joining|in utero embryonic development|initiation of viral infection|isotype switching|negative regulation of neuron apoptosis|neuron apoptosis|nucleotide-excision repair, DNA gap filling|positive regulation of fibroblast proliferation|positive regulation of neurogenesis|pro-B cell differentiation|provirus integration|response to gamma radiation|response to X-ray|single strand break repair|somatic stem cell maintenance|T cell differentiation in thymus|T cell receptor V(D)J recombination	condensed chromosome|cytoplasm|DNA ligase IV complex|DNA-dependent protein kinase-DNA ligase 4 complex|focal adhesion|nucleoplasm	ATP binding|DNA binding|DNA ligase (ATP) activity|metal ion binding|protein C-terminus binding			cervix(1)|endometrium(1)|kidney(1)|large_intestine(9)|lung(22)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	42	all_lung(23;0.000238)|all_neural(89;0.00256)|Lung NSC(43;0.0056)|Medulloblastoma(90;0.00596)|Lung SC(71;0.104)					TGGTGCAGCCAGACCCAACAC	0.468000								Non-homologous end-joining					28	88					0	0	1	0	0
HNRNPCL1	343069	broad.mit.edu	37	1	12907840	12907840	+	Silent	SNP	T	T	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr1:12907840T>A	ENST00000317869.6	-	2	528	c.303A>T	c.(301-303)gcA>gcT	p.A101A		NM_001013631.1|NM_001136561.2|NM_001146181.1	NP_001013653.1|NP_001130033.2|NP_001139653.1			heterogeneous nuclear ribonucleoprotein C-like 1											NS(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(15)|prostate(1)|skin(1)|stomach(2)	29						ACATCTCCGCTGCTGATCGTT	0.493000													13	147					0	0	1	0	0
CD55	1604	broad.mit.edu	37	1	207510124	207510124	+	Missense_Mutation	SNP	C	C	G			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr1:207510124C>G	ENST00000367064.3	+	7	1198	c.940C>G	c.(940-942)Cag>Gag	p.Q314E	CD55_ENST00000391920.4_Missense_Mutation_p.Q314E|CD55_ENST00000314754.8_Missense_Mutation_p.Q314E|CD55_ENST00000465534.1_3'UTR|CD55_ENST00000391921.4_Missense_Mutation_p.Q250E|CD55_ENST00000367065.5_Missense_Mutation_p.Q314E|CD55_ENST00000367067.4_3'UTR|CD55_ENST00000367062.4_Missense_Mutation_p.Q314E|CD55_ENST00000367063.2_Missense_Mutation_p.Q314E	NM_000574.3	NP_000565.1	P08174	DAF_HUMAN	CD55 molecule, decay accelerating factor for complement (Cromer blood group)	314	Ser/Thr-rich.				complement activation, classical pathway|elevation of cytosolic calcium ion concentration|innate immune response|respiratory burst	anchored to membrane|extracellular region|integral to plasma membrane|membrane raft|soluble fraction	receptor activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(4)|ovary(1)|prostate(1)|urinary_tract(1)	16					Chloramphenicol(DB00446)	ACCAACTTCTCAGAAAACCAC	0.413000													11	65					0	0	1	0	0
IGKV1D-43	28891	broad.mit.edu	37	2	90249243	90249243	+	RNA	SNP	A	A	C			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr2:90249243A>C	ENST00000468879.1	+	0	380																											AAAAGCCCCTAAGCTCTTCAT	0.502000													36	232					0	0	1	0	0
IGKV1D-12	28903	broad.mit.edu	37	2	90199072	90199072	+	RNA	SNP	G	G	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr2:90199072G>A	ENST00000390276.2	+	0	414																											AGTTTGCAAAGTGGGGTCCCA	0.507000													26	164					0	0	1	0	0
PPIG	9360	broad.mit.edu	37	2	170487312	170487312	+	Silent	SNP	A	A	G			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr2:170487312A>G	ENST00000260970.3	+	10	796	c.576A>G	c.(574-576)aaA>aaG	p.K192K	PPIG_ENST00000409714.3_Silent_p.K177K|PPIG_ENST00000462903.1_Silent_p.K192K|PPIG_ENST00000448752.2_Silent_p.K192K	NM_004792.2	NP_004783.2	Q13427	PPIG_HUMAN	peptidylprolyl isomerase G (cyclophilin G)	192	Arg/Lys-rich (basic).				protein folding|RNA splicing	nuclear matrix|nuclear speck	cyclosporin A binding|peptidyl-prolyl cis-trans isomerase activity			NS(2)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(8)|liver(1)|lung(17)|ovary(2)|stomach(1)|urinary_tract(1)	43					L-Proline(DB00172)	AAAGGCATAAATCATCATCAT	0.338000													49	110					0	0	1	0	0
LRRIQ3	127255	broad.mit.edu	37	1	74507441	74507441	+	Missense_Mutation	SNP	G	G	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr1:74507441G>A	ENST00000354431.4	-	7	1365	c.1174C>T	c.(1174-1176)Cca>Tca	p.P392S	LRRIQ3_ENST00000395089.1_Missense_Mutation_p.P392S	NM_001105659.1	NP_001099129.1	A6PVS8	LRIQ3_HUMAN	leucine-rich repeats and IQ motif containing 3	392										NS(2)|breast(1)|central_nervous_system(2)|endometrium(7)|kidney(5)|large_intestine(13)|liver(1)|lung(27)|ovary(3)|prostate(1)|skin(5)|soft_tissue(1)|upper_aerodigestive_tract(5)	73						TTAATGATTGGCTTTGGATGA	0.353000													16	86					0	0	1	0	0
IL5RA	3568	broad.mit.edu	37	3	3134047	3134047	+	Splice_Site	SNP	C	C	G			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr3:3134047C>G	ENST00000446632.2	-	9	1430		c.e9-1		IL5RA_ENST00000430514.2_Splice_Site|IL5RA_ENST00000311981.8_Splice_Site|IL5RA_ENST00000445864.2_Intron|IL5RA_ENST00000418488.2_Intron|IL5RA_ENST00000383846.1_Splice_Site|IL5RA_ENST00000256452.3_Splice_Site|IL5RA_ENST00000456302.1_Splice_Site|IL5RA_ENST00000438560.1_Splice_Site	NM_175726.3	NP_783853.1	Q01344	IL5RA_HUMAN	interleukin 5 receptor, alpha						cell proliferation	extracellular space|integral to membrane|plasma membrane	interleukin-5 receptor activity			cervix(1)|endometrium(2)|large_intestine(7)|lung(9)|ovary(1)|prostate(2)|skin(2)	24				Epithelial(13;0.00278)|all cancers(10;0.00809)|OV - Ovarian serous cystadenocarcinoma(96;0.00944)		ATTTTTCTATCTAAGTGGGGA	0.398000													13	68					0	0	1	0	0
DDC	1644	broad.mit.edu	37	7	50611688	50611688	+	Missense_Mutation	SNP	G	G	T	rs11575290	byFrequency	TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr7:50611688G>T	ENST00000444124.2	-	2	296	c.96C>A	c.(94-96)gaC>gaA	p.D32E	DDC_ENST00000380984.4_Missense_Mutation_p.D32E|DDC_ENST00000431062.1_Missense_Mutation_p.D32E|DDC_ENST00000357936.5_Missense_Mutation_p.D32E|DDC_ENST00000426377.1_Missense_Mutation_p.D32E	NM_001082971.1	NP_001076440.1	P20711	DDC_HUMAN	dopa decarboxylase (aromatic L-amino acid decarboxylase)	32					cellular amino acid metabolic process|hormone biosynthetic process|neurotransmitter secretion	cytosol	aromatic-L-amino-acid decarboxylase activity|protein binding|pyridoxal phosphate binding			breast(1)|endometrium(4)|kidney(3)|large_intestine(2)|lung(23)|ovary(4)|skin(2)|stomach(1)	40	Glioma(55;0.08)|all_neural(89;0.245)				Amantadine(DB00915)|Carbidopa(DB00190)|Flupenthixol(DB00875)|L-Tryptophan(DB00150)|Levodopa(DB01235)|Pimozide(DB01100)|Pyridoxal Phosphate(DB00114)|Remoxipride(DB00409)	CGGGCTCCACGTCAGGGTAGA	0.562000													60	215					1.03172e-35	1.58702e-35	1	1	0
TNKS1BP1	85456	broad.mit.edu	37	11	57069608	57069608	+	Missense_Mutation	SNP	C	C	A	rs145115950		TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr11:57069608C>A	ENST00000532437.1	-	7	5085	c.4774G>T	c.(4774-4776)Ggt>Tgt	p.G1592C	TNKS1BP1_ENST00000358252.3_Missense_Mutation_p.G1592C			Q9C0C2	TB182_HUMAN	tankyrase 1 binding protein 1, 182kDa	1592	Arg/Glu/Lys-rich (charged).				nuclear-transcribed mRNA poly(A) tail shortening|telomere maintenance via telomerase	cytoskeleton|cytosol|nuclear telomeric heterochromatin	ankyrin binding|enzyme binding			breast(3)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(11)|lung(24)|ovary(3)|prostate(3)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	64		all_epithelial(135;0.21)				CCCAAGGTACCCCCAGGCCGA	0.602000													13	97					2.31682e-05	2.62573e-05	1	1	0
TMPRSS7	344805	broad.mit.edu	37	3	111785310	111785310	+	Missense_Mutation	SNP	G	G	C			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr3:111785310G>C	ENST00000452346.2	+	13	1630	c.1627G>C	c.(1627-1629)Gac>Cac	p.D543H	TMPRSS7_ENST00000419127.1_Missense_Mutation_p.D417H			Q7RTY8	TMPS7_HUMAN	transmembrane protease, serine 7	543	LDL-receptor class A 2.				proteolysis	integral to membrane|plasma membrane	serine-type endopeptidase activity			breast(2)|endometrium(6)|kidney(2)|large_intestine(4)|lung(11)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	34						TGGCTTCAGGGACTGTGAGAA	0.483000													13	73					0	0	1	0	0
TTC9	23508	broad.mit.edu	37	14	71137808	71137808	+	Missense_Mutation	SNP	G	G	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr14:71137808G>A	ENST00000256367.2	+	3	948	c.605G>A	c.(604-606)cGg>cAg	p.R202Q		NM_015351.1	NP_056166.1	Q92623	TTC9A_HUMAN	tetratricopeptide repeat domain 9	202							binding			skin(1)	1				all cancers(60;0.00545)|BRCA - Breast invasive adenocarcinoma(234;0.00747)|OV - Ovarian serous cystadenocarcinoma(108;0.0538)		AACGTGATTCGGTATATCCAG	0.502000													7	39					0	0	1	0	0
SLC35F5	80255	broad.mit.edu	37	2	114512772	114512772	+	Silent	SNP	C	C	G			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr2:114512772C>G	ENST00000245680.2	-	3	656	c.243G>C	c.(241-243)gtG>gtC	p.V81V	SLC35F5_ENST00000409342.1_Silent_p.V75V	NM_025181.2	NP_079457.2	Q8WV83	S35F5_HUMAN	solute carrier family 35, member F5	81					transport	integral to membrane				endometrium(1)|kidney(4)|large_intestine(2)|lung(7)|ovary(2)|prostate(3)|skin(1)	20						CAACCCATATCACATCAACAA	0.423000													11	51					0	0	1	0	0
OR5H15	403274	broad.mit.edu	37	3	97888297	97888297	+	Missense_Mutation	SNP	T	T	G			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr3:97888297T>G	ENST00000356526.2	+	1	754	c.754T>G	c.(754-756)Tat>Gat	p.Y252D		NM_001005515.1	NP_001005515.1	A6NDH6	O5H15_HUMAN	olfactory receptor, family 5, subfamily H, member 15	252					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(5)|kidney(2)|large_intestine(2)|lung(20)|ovary(1)|prostate(1)|skin(2)|stomach(1)	35						CTGTTTATACTATGGCCCCCT	0.438000													11	75					0	0	1	0	0
RABGGTB	5876	broad.mit.edu	37	1	76255022	76255022	+	Missense_Mutation	SNP	A	A	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr1:76255022A>T	ENST00000319942.3	+	3	361	c.290A>T	c.(289-291)tAc>tTc	p.Y97F	RABGGTB_ENST00000535300.1_5'UTR|RABGGTB_ENST00000496055.1_3'UTR|RABGGTB_ENST00000370826.3_Missense_Mutation_p.Y97F	NM_004582.2	NP_004573.2	P53611	PGTB2_HUMAN	Rab geranylgeranyltransferase, beta subunit	97					protein modification process|visual perception		metal ion binding|protein binding|Rab geranylgeranyltransferase activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(7)|ovary(1)	19						CATCTTTTATACACTCTTAGT	0.363000													9	73					0	0	1	0	0
OPN4	94233	broad.mit.edu	37	10	88415982	88415982	+	Missense_Mutation	SNP	C	C	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr10:88415982C>A	ENST00000372071.2	+	2	442	c.215C>A	c.(214-216)aCc>aAc	p.T72N	OPN4_ENST00000241891.5_Missense_Mutation_p.T72N	NM_001030015.2	NP_001025186.1	Q9UHM6	OPN4_HUMAN	opsin 4	72					phototransduction|protein-chromophore linkage|regulation of circadian rhythm|rhythmic process|visual perception	integral to membrane|plasma membrane	11-cis retinal binding|G-protein coupled photoreceptor activity			breast(1)|endometrium(3)|kidney(2)|large_intestine(2)|liver(2)|lung(5)|ovary(3)	18						GCCCACTATACCCTGGGCACA	0.612000													20	67					1.01871e-10	1.34826e-10	1	1	0
A2M	2	broad.mit.edu	37	12	9248200	9248200	+	Missense_Mutation	SNP	T	T	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr12:9248200T>A	ENST00000318602.7	-	16	2255	c.1948A>T	c.(1948-1950)Att>Ttt	p.I650F		NM_000014.4	NP_000005.2	P01023	A2MG_HUMAN	alpha-2-macroglobulin	650					blood coagulation, intrinsic pathway|negative regulation of complement activation, lectin pathway|platelet activation|platelet degranulation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|extracellular space|platelet alpha granule lumen	enzyme binding|GTPase activator activity|interleukin-1 binding|interleukin-8 binding|serine-type endopeptidase inhibitor activity|tumor necrosis factor binding			breast(1)|central_nervous_system(6)|cervix(1)|endometrium(5)|kidney(6)|large_intestine(17)|lung(30)|ovary(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	77					Bacitracin(DB00626)|Becaplermin(DB00102)	ATTCCATTAATATAGACATTA	0.403000													20	52					0	0	1	0	0
PLEKHA3	65977	broad.mit.edu	37	2	179360225	179360225	+	Missense_Mutation	SNP	C	C	G			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr2:179360225C>G	ENST00000234453.4	+	5	855	c.453C>G	c.(451-453)aaC>aaG	p.N151K		NM_019091.3	NP_061964.3	Q9HB20	PKHA3_HUMAN	pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 3	151						cytoplasm|membrane				endometrium(1)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)	11			OV - Ovarian serous cystadenocarcinoma(117;0.0112)|Epithelial(96;0.0266)|all cancers(119;0.0865)			TTTTTCAGAACATGAATGAAG	0.368000													11	66					0	0	1	0	0
MORC1	27136	broad.mit.edu	37	3	108751647	108751647	+	Missense_Mutation	SNP	C	C	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr3:108751647C>A	ENST00000232603.5	-	16	1567	c.1485G>T	c.(1483-1485)ttG>ttT	p.L495F	MORC1_ENST00000483760.1_Missense_Mutation_p.L495F	NM_014429.3	NP_055244.3	Q86VD1	MORC1_HUMAN	MORC family CW-type zinc finger 1	495					cell differentiation|multicellular organismal development|spermatogenesis	nucleus	ATP binding|zinc ion binding			breast(7)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(14)|lung(47)|ovary(3)|prostate(6)|skin(12)|upper_aerodigestive_tract(3)	105						TAGAGGAAGGCAAGACTCTCC	0.318000													9	40					1.12685e-05	1.29496e-05	1	1	0
FAM150A	389658	broad.mit.edu	37	8	53454951	53454951	+	Splice_Site	SNP	C	C	G			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr8:53454951C>G	ENST00000358543.4	-	2	495		c.e2+1		FAM150A_ENST00000523939.1_Splice_Site	NM_207413.3	NP_997296.1	Q6UXT8	F150A_HUMAN	family with sequence similarity 150, member A							extracellular region				lung(1)	1		Lung NSC(129;0.0919)|all_epithelial(80;0.125)|all_lung(136;0.17)				TTTGTACTTACCTGTGAAATG	0.308000													5	14					0	0	1	0	0
TTLL6	284076	broad.mit.edu	37	17	46867421	46867421	+	Silent	SNP	C	C	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr17:46867421C>T	ENST00000393382.3	-	10	1413	c.1272G>A	c.(1270-1272)gaG>gaA	p.E424E	TTLL6_ENST00000433608.2_Silent_p.E117E	NM_001130918.1	NP_001124390.1	Q8N841	TTLL6_HUMAN	tubulin tyrosine ligase-like family, member 6	376						cilium|microtubule basal body	ATP binding|tubulin binding|tubulin-tyrosine ligase activity			endometrium(1)|large_intestine(5)|lung(9)|prostate(1)|skin(2)	18						CATCTTTCACCTCTTTATCCA	0.512000													8	102					0	0	1	0	0
WBSCR17	64409	broad.mit.edu	37	7	71142265	71142265	+	Missense_Mutation	SNP	T	T	C			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr7:71142265T>C	ENST00000333538.5	+	9	2108	c.1474T>C	c.(1474-1476)Tat>Cat	p.Y492H	WBSCR17_ENST00000498380.2_3'UTR	NM_022479.1	NP_071924.1	Q6IS24	GLTL3_HUMAN	Williams-Beuren syndrome chromosome region 17	492	Ricin B-type lectin.					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			NS(5)|breast(2)|central_nervous_system(1)|endometrium(7)|kidney(7)|large_intestine(22)|lung(45)|ovary(2)|pancreas(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)	100		all_cancers(73;0.2)|Lung NSC(55;0.094)|all_lung(88;0.125)				AGCAATATTGTATCCGTGCCA	0.542000													21	238					0	0	1	0	0
SPATA31A6	389730	broad.mit.edu	37	9	43630635	43630635	+	Missense_Mutation	SNP	G	G	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr9:43630635G>T	ENST00000332857.6	-	1	95	c.67C>A	c.(67-69)Cca>Aca	p.P23T		NM_001145196.1	NP_001138668.1			SPATA31 subfamily A, member 6																		AACACCCATGGTGTGGAGCTG	0.473000													41	39					6.2361e-21	9.27421e-21	1	1	0
ACKR2	1238	broad.mit.edu	37	3	42906034	42906034	+	Missense_Mutation	SNP	G	G	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr3:42906034G>T	ENST00000422265.1	+	3	215	c.40G>T	c.(40-42)Gat>Tat	p.D14Y	ACKR2_ENST00000471537.1_Intron|ACKR2_ENST00000273145.2_Missense_Mutation_p.D14Y|CYP8B1_ENST00000437102.1_Intron|ACKR2_ENST00000442925.1_Missense_Mutation_p.D14Y|KRBOX1_ENST00000426937.1_Intron	NM_001296.4	NP_001287.2			atypical chemokine receptor 2																		CGCCACTGAGGATGCCGATTC	0.542000													14	57					3.27435e-08	4.10752e-08	1	1	0
SYNGR2	9144	broad.mit.edu	37	17	76167811	76167811	+	Silent	SNP	C	C	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr17:76167811C>T	ENST00000588282.1	+	3	564	c.558C>T	c.(556-558)tcC>tcT	p.S186S	SYNGR2_ENST00000589711.1_Intron|SYNGR2_ENST00000585591.1_Intron|SYNGR2_ENST00000590201.1_Intron|SYNGR2_ENST00000225777.3_Intron|SYNGR2_ENST00000592456.1_3'UTR	NM_004710.3	NP_004701.1	O43760	SNG2_HUMAN	synaptogyrin 2	0						integral to plasma membrane				endometrium(2)|large_intestine(1)|liver(1)|lung(1)|skin(1)|urinary_tract(1)	7			BRCA - Breast invasive adenocarcinoma(99;0.00269)|Lung(188;0.0973)|OV - Ovarian serous cystadenocarcinoma(97;0.0994)			TGCTGTGCTCCCCCTGCAGGG	0.632000													11	77					0	0	1	0	0
GABPB1	2553	broad.mit.edu	37	15	50596212	50596212	+	Missense_Mutation	SNP	T	T	C			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr15:50596212T>C	ENST00000380877.3	-	3	650	c.227A>G	c.(226-228)cAt>cGt	p.H76R	GABPB1_ENST00000543881.1_5'UTR|GABPB1_ENST00000560825.1_Missense_Mutation_p.H76R|GABPB1_ENST00000429662.2_Missense_Mutation_p.H76R|GABPB1_ENST00000359031.4_Missense_Mutation_p.H76R|GABPB1_ENST00000220429.8_Missense_Mutation_p.H76R|GABPB1_ENST00000396464.3_Missense_Mutation_p.H76R	NM_005254.5|NM_016654.4	NP_005245.2|NP_057738.1	Q06547	GABP1_HUMAN	GA binding protein transcription factor, beta subunit 1	76				H -> L (in Ref. 7; AA sequence).	positive regulation of transcription from RNA polymerase II promoter	nucleus	protein binding|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			cervix(1)|endometrium(1)|large_intestine(7)|lung(5)	14						AGCTGCCATATGTAATGGTGT	0.438000													20	81					0	0	1	0	0
GRHL2	79977	broad.mit.edu	37	8	102570770	102570770	+	Silent	SNP	G	G	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr8:102570770G>T	ENST00000251808.3	+	4	746	c.408G>T	c.(406-408)cgG>cgT	p.R136R	GRHL2_ENST00000395927.1_Silent_p.R120R	NM_024915.3	NP_079191.2	Q6ISB3	GRHL2_HUMAN	grainyhead-like 2 (Drosophila)	136						cytoplasm|nucleus	DNA binding			breast(3)|central_nervous_system(1)|endometrium(3)|large_intestine(6)|liver(2)|lung(6)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	28	all_cancers(14;4.39e-08)|all_epithelial(15;4.09e-10)|Lung NSC(17;7.11e-06)|all_lung(17;1.44e-05)		Epithelial(11;5.81e-09)|all cancers(13;3.81e-07)|OV - Ovarian serous cystadenocarcinoma(57;0.000213)			ATTCCAAGCGGGAACAGTACA	0.502000													14	138					1.99824e-07	2.43543e-07	1	1	0
CDK17	5128	broad.mit.edu	37	12	96691437	96691437	+	Missense_Mutation	SNP	C	C	G			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr12:96691437C>G	ENST00000261211.3	-	8	1381	c.778G>C	c.(778-780)Gat>Cat	p.D260H	CDK17_ENST00000542666.1_Missense_Mutation_p.D207H|CDK17_ENST00000553042.1_5'UTR|CDK17_ENST00000543119.2_Missense_Mutation_p.D260H	NM_001170464.2|NM_002595.4	NP_001163935.1|NP_002586.2	Q00537	CDK17_HUMAN	cyclin-dependent kinase 17	260	Protein kinase.						ATP binding|cyclin-dependent protein kinase activity			breast(1)|central_nervous_system(1)|endometrium(8)|kidney(3)|large_intestine(6)|lung(11)|ovary(4)|prostate(2)|skin(1)	37						AAGGATTTATCTGTGTGAACA	0.289000													18	74					0	0	1	0	0
SPATA31A3	727830	broad.mit.edu	37	9	40702813	40702813	+	Missense_Mutation	SNP	C	C	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr9:40702813C>A	ENST00000356699.5	+	4	499	c.470C>A	c.(469-471)cCt>cAt	p.P157H	SPATA31A3_ENST00000463536.1_3'UTR	NM_001083124.1	NP_001076593.1			SPATA31 subfamily A, member 3																		TCCCCGGATCCTCAAGCCAAG	0.592000													76	349					5.72486e-32	8.77872e-32	1	1	0
APOBR	55911	broad.mit.edu	37	16	28509653	28509653	+	Silent	SNP	A	A	G			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr16:28509653A>G	ENST00000564831.1	+	3	3240	c.3207A>G	c.(3205-3207)agA>agG	p.R1069R	APOBR_ENST00000431282.1_Silent_p.R1060R|APOBR_ENST00000328423.5_Intron	NM_018690.3	NP_061160.3	Q0VD83	APOBR_HUMAN	apolipoprotein B receptor	1060					cholesterol metabolic process|lipid transport	chylomicron|low-density lipoprotein particle|plasma membrane|very-low-density lipoprotein particle				breast(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(11)|prostate(1)|skin(2)|stomach(1)	29						CAGCCAGGAGAAGGCCCCTGG	0.667000													4	8					0	0	1	0	0
TMEM135	65084	broad.mit.edu	37	11	87029210	87029210	+	Missense_Mutation	SNP	A	A	G			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr11:87029210A>G	ENST00000340353.7	+	12	1245	c.1043A>G	c.(1042-1044)aAg>aGg	p.K348R	TMEM135_ENST00000535167.1_Missense_Mutation_p.K231R|TMEM135_ENST00000305494.5_Missense_Mutation_p.K370R|TMEM135_ENST00000532959.1_Missense_Mutation_p.K241R	NM_001168724.1	NP_001162195.1	Q86UB9	TM135_HUMAN	transmembrane protein 135	370						integral to membrane				NS(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(6)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	17		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.0123)				GAAGCAGGGAAGGTTCCCTAT	0.343000													20	58					0	0	1	0	0
TBX2	6909	broad.mit.edu	37	17	59479158	59479158	+	Missense_Mutation	SNP	C	C	G			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr17:59479158C>G	ENST00000240328.3	+	2	790	c.509C>G	c.(508-510)tCg>tGg	p.S170W	RP11-332H18.4_ENST00000592009.1_RNA	NM_005994.3	NP_005985.3	Q13207	TBX2_HUMAN	T-box 2	170					cell aging|positive regulation of cell proliferation		sequence-specific DNA binding			endometrium(1)|lung(7)|ovary(1)	9						TTCCACAACTCGCGCTGGATG	0.592000													16	80					0	0	1	0	0
LINC00639	283547	broad.mit.edu	37	14	39304855	39304855	+	RNA	SNP	G	G	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr14:39304855G>A	ENST00000553932.1	-	0	3707																											CCCTAAGAGTGCAGTTAATGG	0.473000													5	51					0	0	1	0	0
TTLL6	284076	broad.mit.edu	37	17	46867420	46867420	+	Missense_Mutation	SNP	C	C	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr17:46867420C>A	ENST00000393382.3	-	10	1414	c.1273G>T	c.(1273-1275)Gtg>Ttg	p.V425L	TTLL6_ENST00000433608.2_Missense_Mutation_p.V118L	NM_001130918.1	NP_001124390.1	Q8N841	TTLL6_HUMAN	tubulin tyrosine ligase-like family, member 6	377						cilium|microtubule basal body	ATP binding|tubulin binding|tubulin-tyrosine ligase activity			endometrium(1)|large_intestine(5)|lung(9)|prostate(1)|skin(2)	18						CCATCTTTCACCTCTTTATCC	0.512000													9	103					0.000442599	0.00048115	1	1	0
SLCO1A2	6579	broad.mit.edu	37	12	21467596	21467596	+	Silent	SNP	T	T	G			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr12:21467596T>G	ENST00000307378.6	-	5	942	c.222A>C	c.(220-222)atA>atC	p.I74I	SLCO1A2_ENST00000473830.1_Intron|SLCO1A2_ENST00000537524.1_Intron|SLCO1A2_ENST00000390670.3_Silent_p.I72I|SLCO1A2_ENST00000458504.1_Intron|SLCO1A2_ENST00000452078.1_Silent_p.I74I	NM_134431.3	NP_602307.1	P46721	SO1A2_HUMAN	solute carrier organic anion transporter family, member 1A2	74					bile acid metabolic process|sodium-independent organic anion transport	integral to membrane|plasma membrane	bile acid transmembrane transporter activity|organic anion transmembrane transporter activity			breast(2)|endometrium(2)|kidney(4)|large_intestine(8)|lung(23)|ovary(1)|pancreas(1)|skin(6)|upper_aerodigestive_tract(1)	48						AACTCACAAATATAATCAACA	0.313000													12	41					0	0	1	0	0
CREBBP	1387	broad.mit.edu	37	16	3795338	3795338	+	Missense_Mutation	SNP	T	T	C			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr16:3795338T>C	ENST00000262367.5	-	22	4663	c.3854A>G	c.(3853-3855)gAg>gGg	p.E1285G	CREBBP_ENST00000382070.3_Missense_Mutation_p.E1247G	NM_004380.2	NP_004371.2	Q92793	CBP_HUMAN	CREB binding protein	1285	Cys/His-rich.				cellular lipid metabolic process|homeostatic process|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|protein complex assembly|response to hypoxia	cytoplasm|nuclear body	histone acetyltransferase activity|MyoD binding|p53 binding|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription coactivator activity|zinc ion binding			NS(1)|breast(5)|central_nervous_system(4)|cervix(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(125)|kidney(5)|large_intestine(32)|lung(43)|ovary(18)|pancreas(2)|prostate(6)|skin(9)|soft_tissue(1)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(21)	295		Ovarian(90;0.0266)		OV - Ovarian serous cystadenocarcinoma(1;3.54e-05)		CCGGCCACACTCCTTGCAATC	0.517000			"""T, N, F, Mis, O"""	"""MLL, MORF, RUNXBP2"""	"""ALL, AML, DLBCL, B-NHL """		Rubinstein-Taybi syndrome						20	36					0	0	1	0	0
YWHAG	7532	broad.mit.edu	37	7	75988083	75988083	+	Nonsense_Mutation	SNP	C	C	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr7:75988083C>A	ENST00000307630.3	-	1	265	c.43G>T	c.(43-45)Gag>Tag	p.E15*		NM_012479.3	NP_036611.2	P61981	1433G_HUMAN	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide	15					G2/M transition of mitotic cell cycle|regulation of neuron differentiation|regulation of signal transduction|regulation of synaptic plasticity	cytosol	insulin-like growth factor receptor binding|protein kinase C binding|protein kinase C inhibitor activity			endometrium(2)|large_intestine(1)|lung(2)|ovary(2)|prostate(1)	8						TCCGCCTGCTCGGCCAGCCGG	0.697000													5	46					0.00116845	0.00124685	1	1	0
LIG4	3981	broad.mit.edu	37	13	108862288	108862288	+	Silent	SNP	T	T	C			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr13:108862288T>C	ENST00000356922.4	-	2	1601	c.1329A>G	c.(1327-1329)agA>agG	p.R443R	LIG4_ENST00000405925.1_Silent_p.R443R|LIG4_ENST00000442234.1_Silent_p.R443R	NM_002312.3|NM_206937.1	NP_002303.2|NP_996820.1	P49917	DNLI4_HUMAN	ligase IV, DNA, ATP-dependent	443					cell cycle|cell division|cell proliferation|central nervous system development|chromosome organization|DNA ligation involved in DNA recombination|DNA ligation involved in DNA repair|DNA replication|double-strand break repair via nonhomologous end joining|in utero embryonic development|initiation of viral infection|isotype switching|negative regulation of neuron apoptosis|neuron apoptosis|nucleotide-excision repair, DNA gap filling|positive regulation of fibroblast proliferation|positive regulation of neurogenesis|pro-B cell differentiation|provirus integration|response to gamma radiation|response to X-ray|single strand break repair|somatic stem cell maintenance|T cell differentiation in thymus|T cell receptor V(D)J recombination	condensed chromosome|cytoplasm|DNA ligase IV complex|DNA-dependent protein kinase-DNA ligase 4 complex|focal adhesion|nucleoplasm	ATP binding|DNA binding|DNA ligase (ATP) activity|metal ion binding|protein C-terminus binding			cervix(1)|endometrium(1)|kidney(1)|large_intestine(9)|lung(22)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	42	all_lung(23;0.000238)|all_neural(89;0.00256)|Lung NSC(43;0.0056)|Medulloblastoma(90;0.00596)|Lung SC(71;0.104)					ACCCTTCACCTCTTTTGTCTG	0.368000								Non-homologous end-joining					38	154					0	0	1	0	0
FZD5	7855	broad.mit.edu	37	2	208632263	208632263	+	Missense_Mutation	SNP	G	G	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr2:208632263G>A	ENST00000295417.3	-	2	1754	c.1201C>T	c.(1201-1203)Cgc>Tgc	p.R401C		NM_003468.3	NP_003459.2	Q13467	FZD5_HUMAN	frizzled family receptor 5	401					angiogenesis|anterior/posterior axis specification, embryo|axonogenesis|brain development|canonical Wnt receptor signaling pathway|cellular response to molecule of bacterial origin|embryonic camera-type eye development|gonad development|labyrinthine layer blood vessel development|positive regulation of interferon-gamma production|positive regulation of transcription from RNA polymerase II promoter|post-embryonic camera-type eye development|Spemann organizer formation|T cell differentiation in thymus|Wnt receptor signaling pathway involved in dorsal/ventral axis specification	cell projection|cell surface|Golgi membrane|integral to membrane|plasma membrane	G-protein coupled receptor activity|PDZ domain binding|protein kinase binding|Wnt-protein binding			NS(1)|kidney(1)|lung(1)|ovary(2)|prostate(1)|skin(1)	7				LUSC - Lung squamous cell carcinoma(261;0.0703)|Epithelial(149;0.13)|Lung(261;0.134)		ACGAAGCCGCGCAGCGAGTTC	0.667000													16	54					0	0	1	0	0
LMO7	4008	broad.mit.edu	37	13	76409419	76409419	+	Missense_Mutation	SNP	G	G	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr13:76409419G>A	ENST00000357063.3	+	19	4693	c.3433G>A	c.(3433-3435)Gaa>Aaa	p.E1145K	LMO7_ENST00000321797.8_Missense_Mutation_p.E860K|LMO7_ENST00000526202.1_Missense_Mutation_p.E737K|LMO7_ENST00000341547.4_Missense_Mutation_p.E811K|LMO7_ENST00000377534.3_Missense_Mutation_p.E1145K|LMO7_ENST00000465261.2_Missense_Mutation_p.E860K			Q8WWI1	LMO7_HUMAN	LIM domain 7	1145						cytoplasm|nucleus|ubiquitin ligase complex	ubiquitin-protein ligase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(2)|kidney(2)|large_intestine(20)|lung(15)|ovary(2)|prostate(5)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	56		Breast(118;0.0992)		GBM - Glioblastoma multiforme(99;0.0109)		TTACAACTCAGAAAAATCTTC	0.383000													6	84					0	0	1	0	0
DHX8	1659	broad.mit.edu	37	17	41561481	41561481	+	Missense_Mutation	SNP	G	G	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr17:41561481G>A	ENST00000262415.3	+	1	148	c.76G>A	c.(76-78)Gag>Aag	p.E26K	DHX8_ENST00000540306.1_Missense_Mutation_p.E26K	NM_004941.1	NP_004932.1	Q14562	DHX8_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 8	26						catalytic step 2 spliceosome	ATP binding|ATP-dependent RNA helicase activity|protein binding|RNA binding			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(9)|lung(17)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|urinary_tract(1)	42		Breast(137;0.00908)		BRCA - Breast invasive adenocarcinoma(366;0.08)		TGCCAAACTCGAGTACCTGTC	0.582000											OREG0024434	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	18	124					0	0	1	0	0
SVEP1	79987	broad.mit.edu	37	9	113141644	113141644	+	Nonsense_Mutation	SNP	G	G	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr9:113141644G>T	ENST00000401783.2	-	44	10727	c.10391C>A	c.(10390-10392)tCa>tAa	p.S3464*	SVEP1_ENST00000374469.1_Nonsense_Mutation_p.S3441*|SVEP1_ENST00000297826.5_Nonsense_Mutation_p.S1390*	NM_153366.3	NP_699197.3	Q4LDE5	SVEP1_HUMAN	sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1	3464	Sushi 34.				cell adhesion	cytoplasm|extracellular region|membrane	calcium ion binding			NS(1)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|cervix(2)|endometrium(19)|kidney(8)|large_intestine(24)|lung(58)|ovary(7)|prostate(7)|skin(1)|stomach(4)|upper_aerodigestive_tract(5)|urinary_tract(4)	147						AATAGGAGGTGATGTCCATGT	0.363000													7	31					0.00198382	0.00210327	1	1	0
UBE2Z	65264	broad.mit.edu	37	17	46998559	46998559	+	Missense_Mutation	SNP	G	G	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr17:46998559G>T	ENST00000360943.5	+	5	863	c.728G>T	c.(727-729)tGt>tTt	p.C243F		NM_023079.4	NP_075567.2	Q9H832	UBE2Z_HUMAN	ubiquitin-conjugating enzyme E2Z	243					apoptosis	cytoplasm|nucleus	ATP binding|ubiquitin-protein ligase activity										TATAATGAATGTATCCGGCAC	0.453000													4	23					0.00909568	0.00946027	1	1	0
UGT8	7368	broad.mit.edu	37	4	115544098	115544098	+	Missense_Mutation	SNP	C	C	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr4:115544098C>A	ENST00000310836.6	+	2	584	c.62C>A	c.(61-63)gCc>gAc	p.A21D	UGT8_ENST00000394511.3_Missense_Mutation_p.A21D	NM_001128174.1	NP_001121646.1	Q16880	CGT_HUMAN	UDP glycosyltransferase 8	21					central nervous system development|peripheral nervous system development	integral to membrane	2-hydroxyacylsphingosine 1-beta-galactosyltransferase activity|UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(11)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	31		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.000632)		GCGAAGGCTGCCAAAATCATC	0.423000													6	38					0.00116845	0.00124685	1	1	0
FAM41C	284593	broad.mit.edu	37	1	809876	809876	+	RNA	SNP	A	A	G	rs57181708	by1000genomes	TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr1:809876A>G	ENST00000446136.1	-	0	817					NR_027055.1																						AGTTTTGCCTAATATTTTCAC	0.458000													3	21					0	0	1	0	0
DMXL1	1657	broad.mit.edu	37	5	118485974	118485974	+	Missense_Mutation	SNP	G	G	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr5:118485974G>T	ENST00000311085.8	+	18	4532	c.4452G>T	c.(4450-4452)gaG>gaT	p.E1484D	DMXL1_ENST00000539542.1_Missense_Mutation_p.E1484D	NM_005509.4	NP_005500.4	Q9Y485	DMXL1_HUMAN	Dmx-like 1	1484										breast(3)|central_nervous_system(1)|endometrium(14)|kidney(4)|large_intestine(20)|liver(6)|lung(28)|ovary(2)|prostate(5)|skin(2)|upper_aerodigestive_tract(1)	86		all_cancers(142;0.0314)|all_epithelial(76;0.00559)|Prostate(80;0.11)|Breast(839;0.231)		OV - Ovarian serous cystadenocarcinoma(64;0.000563)|Epithelial(69;0.00179)|all cancers(49;0.0243)		TTGGACCTGAGCATGCTCAGG	0.418000													28	111					1.88708e-17	2.72825e-17	1	1	0
FAT4	79633	broad.mit.edu	37	4	126402712	126402712	+	Missense_Mutation	SNP	A	A	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr4:126402712A>T	ENST00000394329.3	+	15	12648	c.12635A>T	c.(12634-12636)aAa>aTa	p.K4212I	FAT4_ENST00000335110.5_Missense_Mutation_p.K2453I	NM_024582.4	NP_078858.4	Q6V0I7	FAT4_HUMAN	FAT atypical cadherin 4	4212					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						TTAGAAGGCAAAGGGCGCTTG	0.433000													13	64					0	0	1	0	0
BRD4	23476	broad.mit.edu	37	19	15383769	15383769	+	Missense_Mutation	SNP	G	G	C			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr19:15383769G>C	ENST00000263377.2	-	2	363	c.142C>G	c.(142-144)Cca>Gca	p.P48A	BRD4_ENST00000360016.5_Missense_Mutation_p.P48A|BRD4_ENST00000371835.4_Missense_Mutation_p.P48A	NM_058243.2	NP_490597.1	O60885	BRD4_HUMAN	bromodomain containing 4	48					interspecies interaction between organisms|positive regulation of G2/M transition of mitotic cell cycle|positive regulation of transcription elongation from RNA polymerase II promoter|regulation of transcription involved in G1 phase of mitotic cell cycle	condensed nuclear chromosome|cytoplasm	protein binding			breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(2)|lung(7)|ovary(2)|urinary_tract(1)	21			OV - Ovarian serous cystadenocarcinoma(3;3.02e-24)|Epithelial(3;4.71e-20)|all cancers(3;2.26e-18)			GAGGTCTCTGGGGGCGGGGGG	0.567000			T	C15orf55	lethal midline carcinoma of young people								58	93					0	0	1	0	0
CD5	921	broad.mit.edu	37	11	60885680	60885680	+	Missense_Mutation	SNP	A	A	C			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr11:60885680A>C	ENST00000347785.3	+	3	294	c.128A>C	c.(127-129)aAg>aCg	p.K43T		NM_014207.3	NP_055022.2	P06127	CD5_HUMAN	CD5 molecule	43	SRCR 1.				cell proliferation|cell recognition	integral to plasma membrane	scavenger receptor activity			central_nervous_system(1)|large_intestine(4)|lung(10)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	19		all_lung(304;5.94e-05)|Lung NSC(402;7.26e-05)		BRCA - Breast invasive adenocarcinoma(625;0.000946)|Lung(977;0.0086)|LUSC - Lung squamous cell carcinoma(625;0.0528)		TCCAACTCGAAGTGCCAGGGC	0.637000													26	122					0	0	1	0	0
ANKAR	150709	broad.mit.edu	37	2	190571803	190571803	+	Missense_Mutation	SNP	C	C	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr2:190571803C>T	ENST00000520309.1	+	9	2138	c.2050C>T	c.(2050-2052)Cat>Tat	p.H684Y	ANKAR_ENST00000313581.4_Missense_Mutation_p.H684Y|ANKAR_ENST00000431575.2_Missense_Mutation_p.H613Y|ANKAR_ENST00000281412.6_Missense_Mutation_p.H448Y|ANKAR_ENST00000438402.2_Missense_Mutation_p.H684Y	NM_144708.3	NP_653309.3	Q7Z5J8	ANKAR_HUMAN	ankyrin and armadillo repeat containing	684						integral to membrane	binding			breast(3)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(7)|liver(2)|lung(16)|ovary(2)|pancreas(1)|skin(1)|urinary_tract(2)	46			OV - Ovarian serous cystadenocarcinoma(117;0.00156)|Epithelial(96;0.0256)|all cancers(119;0.0744)			GTTAACCTTTCATACAGAGGT	0.308000													5	44					0	0	1	0	0
OR4A16	81327	broad.mit.edu	37	11	55111383	55111383	+	Missense_Mutation	SNP	C	C	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr11:55111383C>A	ENST00000314721.2	+	1	757	c.707C>A	c.(706-708)cCt>cAt	p.P236H		NM_001005274.1	NP_001005274.1	Q8NH70	O4A16_HUMAN	olfactory receptor, family 4, subfamily A, member 16	236					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(28)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	51						AAAGCCCTGCCTACCTGCATC	0.398000													17	71					1.5739e-10	2.07191e-10	1	1	0
CDK14	5218	broad.mit.edu	37	7	90613533	90613533	+	Missense_Mutation	SNP	G	G	C			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr7:90613533G>C	ENST00000406263.1	+	9	1322	c.880G>C	c.(880-882)Gat>Cat	p.D294H	CDK14_ENST00000265741.3_Missense_Mutation_p.D322H|CDK14_ENST00000380050.3_Missense_Mutation_p.D340H|CDK14_ENST00000436577.2_Missense_Mutation_p.D211H			O94921	CDK14_HUMAN	cyclin-dependent kinase 14	340	Protein kinase.				cell division|G2/M transition of mitotic cell cycle|regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	cytoplasmic cyclin-dependent protein kinase holoenzyme complex|nucleus|plasma membrane	ATP binding|cyclin binding|cyclin-dependent protein kinase activity			breast(2)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(6)|liver(1)|lung(12)|ovary(1)|skin(4)	32						AGACATTCAGGATCAACTTGA	0.363000													12	106					0	0	1	0	0
NAV3	89795	broad.mit.edu	37	12	78569105	78569105	+	Missense_Mutation	SNP	G	G	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr12:78569105G>T	ENST00000397909.2	+	25	5174	c.5001G>T	c.(4999-5001)caG>caT	p.Q1667H	NAV3_ENST00000266692.7_Missense_Mutation_p.Q1490H|NAV3_ENST00000536525.2_Missense_Mutation_p.Q1667H|NAV3_ENST00000228327.6_Missense_Mutation_p.Q1667H			Q8IVL0	NAV3_HUMAN	neuron navigator 3	1667						nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			NS(2)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(13)|kidney(16)|large_intestine(39)|liver(2)|lung(126)|ovary(5)|pancreas(3)|prostate(6)|skin(5)|stomach(2)|upper_aerodigestive_tract(8)|urinary_tract(1)	236						TCAGAAGACAGCATTCCTCTG	0.418000										HNSCC(70;0.22)			8	30					5.18039e-06	6.03767e-06	1	1	0
ZDBF2	57683	broad.mit.edu	37	2	207176100	207176100	+	Missense_Mutation	SNP	C	C	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr2:207176100C>T	ENST00000374423.3	+	5	7234	c.6848C>T	c.(6847-6849)tCa>tTa	p.S2283L		NM_020923.1	NP_065974.1	Q9HCK1	ZDBF2_HUMAN	zinc finger, DBF-type containing 2	2283							nucleic acid binding|zinc ion binding			endometrium(4)|kidney(5)|large_intestine(28)|lung(50)|ovary(4)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	95						GAAGAGCTGTCAAGCGCTATG	0.498000													3	12					0	0	1	0	0
CCDC19	25790	broad.mit.edu	37	1	159858261	159858261	+	Nonsense_Mutation	SNP	C	C	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr1:159858261C>A	ENST00000426543.2	-	4	498	c.43G>T	c.(43-45)Gag>Tag	p.E15*	CCDC19_ENST00000476696.1_5'UTR|CCDC19_ENST00000368099.4_Nonsense_Mutation_p.E100*			Q9UL16	CCD19_HUMAN	coiled-coil domain containing 19	100						mitochondrion|soluble fraction				endometrium(2)|large_intestine(7)|lung(11)|ovary(1)|prostate(2)|skin(1)|urinary_tract(2)	26	all_hematologic(112;0.0597)		BRCA - Breast invasive adenocarcinoma(70;0.151)			ATTAGGGACTCCCCGGAGGGA	0.532000													11	79					1.49906e-05	1.70875e-05	1	1	0
SLC44A4	80736	broad.mit.edu	37	6	31839280	31839280	+	Silent	SNP	G	G	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr6:31839280G>A	ENST00000544672.1	-	8	656	c.360C>T	c.(358-360)acC>acT	p.T120T	SLC44A4_ENST00000375562.4_Silent_p.T154T|SLC44A4_ENST00000229729.6_Silent_p.T196T	NM_001178045.1	NP_001171516.1	Q53GD3	CTL4_HUMAN	solute carrier family 44, member 4	196						integral to membrane|plasma membrane	choline transmembrane transporter activity			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(11)|ovary(2)|prostate(3)|skin(1)|urinary_tract(2)	35					Choline(DB00122)	TGGTGTCATTGGTGATCCCTG	0.647000													12	81					0	0	1	0	0
FAM155A	728215	broad.mit.edu	37	13	107822961	107822961	+	Missense_Mutation	SNP	C	C	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr13:107822961C>A	ENST00000375915.2	-	3	1399	c.1261G>T	c.(1261-1263)Gtt>Ttt	p.V421F		NM_001080396.2	NP_001073865.1	B1AL88	F155A_HUMAN	family with sequence similarity 155, member A	421						integral to membrane	binding			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(11)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	33						AGTACAAGAACACACAGCTTG	0.517000													7	37					8.12818e-05	8.98474e-05	1	1	0
COX11	1353	broad.mit.edu	37	17	53045693	53045693	+	Silent	SNP	G	G	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr17:53045693G>A	ENST00000299335.3	-	1	453	c.315C>T	c.(313-315)ggC>ggT	p.G105G	COX11_ENST00000571584.1_Silent_p.G105G	NM_004375.3	NP_004366.1	Q9Y6N1	COX11_HUMAN	cytochrome c oxidase assembly homolog 11 (yeast)	105					respiratory chain complex IV assembly|respiratory gaseous exchange	integral to membrane|mitochondrial inner membrane	copper ion binding|cytochrome-c oxidase activity|electron carrier activity			endometrium(1)|kidney(1)|large_intestine(1)|liver(2)|lung(2)|ovary(1)|prostate(1)	9						CCCCCAGCATGCCCACGGCGA	0.697000													11	78					0	0	1	0	0
PROX1	5629	broad.mit.edu	37	1	214170934	214170934	+	Missense_Mutation	SNP	G	G	C			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr1:214170934G>C	ENST00000366958.4	+	2	1664	c.1056G>C	c.(1054-1056)ttG>ttC	p.L352F	PROX1_ENST00000498508.2_Missense_Mutation_p.L352F|PROX1_ENST00000261454.4_Missense_Mutation_p.L352F|PROX1_ENST00000435016.1_Missense_Mutation_p.L352F	NM_001270616.1	NP_001257545.1	Q92786	PROX1_HUMAN	prospero homeobox 1	352					aorta smooth muscle tissue morphogenesis|atrial cardiac muscle tissue morphogenesis|brain development|dorsal spinal cord development|embryonic retina morphogenesis in camera-type eye|endocardium formation|hepatocyte differentiation|kidney development|lens fiber cell morphogenesis|lung development|lymphangiogenesis|negative regulation of bile acid biosynthetic process|negative regulation of cell proliferation|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of viral genome replication|neural tube development|olfactory placode formation|optic placode formation involved in camera-type eye formation|otic placode formation|pancreas development|positive regulation of cyclin-dependent protein kinase activity|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of heart growth|positive regulation of S phase of mitotic cell cycle|positive regulation of sarcomere organization|positive regulation of transcription, DNA-dependent|regulation of transcription involved in lymphatic endothelial cell fate commitment|skeletal muscle thin filament assembly|venous blood vessel morphogenesis|ventricular cardiac muscle tissue morphogenesis|ventricular cardiac myofibril development|ventricular septum morphogenesis	cytoplasm|nucleus	DBD domain binding|LBD domain binding|ligand-dependent nuclear receptor binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription corepressor activity|transcription regulatory region DNA binding			autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(6)|lung(15)|ovary(3)|prostate(2)|skin(4)	47				OV - Ovarian serous cystadenocarcinoma(81;0.0179)|all cancers(67;0.0488)|GBM - Glioblastoma multiforme(131;0.188)|Epithelial(68;0.219)		CTGAGACCTTGAAACAGGAAC	0.512000													17	94					0	0	1	0	0
GDPD3	79153	broad.mit.edu	37	16	30119753	30119753	+	Splice_Site	SNP	C	C	G			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr16:30119753C>G	ENST00000406256.3	-	8	1085	c.707_splice	c.e8-1	p.R236_splice	RP11-455F5.4_ENST00000566190.1_RNA	NM_024307.2	NP_077283.2	Q7L5L3	GDPD3_HUMAN	glycerophosphodiester phosphodiesterase domain containing 3	236	GDPD.				glycerol metabolic process|lipid metabolic process	integral to membrane	glycerophosphodiester phosphodiesterase activity|metal ion binding			biliary_tract(1)|breast(1)|central_nervous_system(1)|large_intestine(2)|lung(6)	11						GGAAATAGGTCCTGCAGAGAG	0.587000													50	82					0	0	1	0	0
ARHGAP32	9743	broad.mit.edu	37	11	128839713	128839713	+	Missense_Mutation	SNP	C	C	G	rs147135511		TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr11:128839713C>G	ENST00000310343.9	-	22	5352	c.5353G>C	c.(5353-5355)Ggt>Cgt	p.G1785R	ARHGAP32_ENST00000527272.1_Missense_Mutation_p.G1436R|ARHGAP32_ENST00000392657.3_Missense_Mutation_p.G1436R|ARHGAP32_ENST00000524655.1_3'UTR	NM_001142685.1	NP_001136157.1	A7KAX9	RHG32_HUMAN	Rho GTPase activating protein 32	1785	Interaction with FYN.				cell communication|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cell cortex|cell junction|cytosol|dendritic spine|endoplasmic reticulum membrane|endosome membrane|Golgi membrane|postsynaptic density|postsynaptic membrane	GTPase activator activity|phosphatidylinositol binding			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(12)|lung(28)|ovary(3)|prostate(6)|urinary_tract(3)	60						TAGATCCCACCCAAGTCGTCC	0.552000													32	113					0	0	1	0	0
SLC22A7	10864	broad.mit.edu	37	6	43271893	43271893	+	Missense_Mutation	SNP	C	C	G			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr6:43271893C>G	ENST00000372585.5	+	10	1598	c.1503C>G	c.(1501-1503)atC>atG	p.I501M	SLC22A7_ENST00000372574.3_Missense_Mutation_p.I499M|SLC22A7_ENST00000372589.3_Missense_Mutation_p.I499M	NM_153320.2	NP_696961.2	Q9Y694	S22A7_HUMAN	solute carrier family 22 (organic anion transporter), member 7	501						basolateral plasma membrane|integral to plasma membrane|membrane fraction	anion:anion antiporter activity|sodium-independent organic anion transmembrane transporter activity	p.I501I(1)		NS(2)|endometrium(1)|kidney(1)|large_intestine(8)|lung(10)|prostate(1)|skin(3)	26			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.00998)|OV - Ovarian serous cystadenocarcinoma(102;0.0305)			ATGGGGGGATCGCCCTGCTGG	0.652000													30	104					0	0	1	0	0
PACRG	135138	broad.mit.edu	37	6	163235181	163235181	+	Silent	SNP	G	G	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr6:163235181G>A	ENST00000337019.3	+	3	383	c.159G>A	c.(157-159)gtG>gtA	p.V53V	PACRG_ENST00000366889.2_Silent_p.V53V|PACRG_ENST00000366888.2_Silent_p.V53V|PACRG_ENST00000542669.1_3'UTR	NM_152410.2	NP_689623.2	Q96M98	PACRG_HUMAN	PARK2 co-regulated	53										endometrium(2)|large_intestine(6)|lung(8)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	20		Breast(66;2.41e-05)|Ovarian(120;0.0245)|Prostate(117;0.0273)|all_neural(5;0.0416)|Glioma(2;0.203)		OV - Ovarian serous cystadenocarcinoma(33;4.31e-19)|GBM - Glioblastoma multiforme(2;7.42e-11)|BRCA - Breast invasive adenocarcinoma(81;3.19e-05)|KIRC - Kidney renal clear cell carcinoma(3;0.205)|Kidney(3;0.242)		CAATTAAGGTGAGAGGCCCTC	0.368000													8	88					0	0	1	0	0
ZNF536	9745	broad.mit.edu	37	19	31025884	31025884	+	Missense_Mutation	SNP	G	G	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr19:31025884G>T	ENST00000355537.3	+	3	2448	c.2301G>T	c.(2299-2301)aaG>aaT	p.K767N		NM_014717.1	NP_055532.1	O15090	ZN536_HUMAN	zinc finger protein 536	767					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			NS(3)|breast(6)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|lung(119)|ovary(7)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(3)	182	Esophageal squamous(110;0.0834)					ATCACCTTAAGGTGCACCTGA	0.602000													58	105					2.17126e-26	3.28353e-26	1	1	0
SSBP2	23635	broad.mit.edu	37	5	80809459	80809459	+	Silent	SNP	T	T	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr5:80809459T>A	ENST00000320672.4	-	5	570	c.360A>T	c.(358-360)ccA>ccT	p.P120P	SSBP2_ENST00000505980.1_Silent_p.P120P|SSBP2_ENST00000509053.1_Intron|SSBP2_ENST00000515395.1_Intron|SSBP2_ENST00000514493.1_Intron	NM_001256732.1|NM_001256733.1|NM_012446.3	NP_001243661.1|NP_001243662.1|NP_036578.2	P81877	SSBP2_HUMAN	single-stranded DNA binding protein 2	120	Pro-rich.				regulation of transcription, DNA-dependent	cytoplasm|nucleus	single-stranded DNA binding		SSBP2/JAK2(4)	central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(3)|skin(1)	10		Lung NSC(167;0.00154)|all_lung(232;0.00179)|Ovarian(174;0.0338)		OV - Ovarian serous cystadenocarcinoma(54;1.07e-41)|Epithelial(54;2.79e-35)|all cancers(79;1.18e-29)		GAAAGAACCCTGGTGGTACAG	0.443000													17	74					0	0	1	0	0
PAPPA2	60676	broad.mit.edu	37	1	176734958	176734958	+	Nonsense_Mutation	SNP	C	C	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr1:176734958C>A	ENST00000367662.3	+	15	5472	c.4308C>A	c.(4306-4308)taC>taA	p.Y1436*		NM_020318.2	NP_064714.2	Q9BXP8	PAPP2_HUMAN	pappalysin 2	1436	Sushi 1.				cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			NS(3)|breast(3)|central_nervous_system(7)|cervix(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(19)|lung(136)|ovary(7)|pancreas(1)|prostate(4)|skin(10)|upper_aerodigestive_tract(8)|urinary_tract(1)	226						GTGGGCAGTACATCAGGCCCA	0.517000													47	69					4.44401e-20	6.57927e-20	1	1	0
PLCL1	5334	broad.mit.edu	37	2	198949102	198949102	+	Missense_Mutation	SNP	C	C	G			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr2:198949102C>G	ENST00000428675.1	+	2	1259	c.861C>G	c.(859-861)atC>atG	p.I287M	PLCL1_ENST00000437704.2_Missense_Mutation_p.I189M	NM_006226.3	NP_006217.3	Q15111	PLCL1_HUMAN	phospholipase C-like 1	287					intracellular signal transduction|lipid metabolic process	cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(8)|kidney(1)|large_intestine(14)|lung(44)|ovary(1)|pancreas(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	80					Quinacrine(DB01103)	TTAAAGAAATCCAGAAGAGCA	0.408000													21	118					0	0	1	0	0
EPHB3	2049	broad.mit.edu	37	3	184290795	184290795	+	Silent	SNP	G	G	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr3:184290795G>A	ENST00000330394.2	+	3	1139	c.687G>A	c.(685-687)gcG>gcA	p.A229A	EIF2B5_ENST00000444495.1_Intron	NM_004443.3	NP_004434.2	P54753	EPHB3_HUMAN	EPH receptor B3	229	Cys-rich.					integral to plasma membrane	ATP binding|ephrin receptor activity			breast(5)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(22)|ovary(5)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	51	all_cancers(143;1.89e-10)|Ovarian(172;0.0339)		Epithelial(37;1.27e-34)|OV - Ovarian serous cystadenocarcinoma(80;3.8e-22)			TCACTGGGGCGGAGCCCACCT	0.637000													16	87					0	0	1	0	0
TLR2	7097	broad.mit.edu	37	4	154626144	154626144	+	Missense_Mutation	SNP	G	G	C			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr4:154626144G>C	ENST00000260010.6	+	1	3493	c.2085G>C	c.(2083-2085)aaG>aaC	p.K695N		NM_003264.3	NP_003255.2	O60603	TLR2_HUMAN	toll-like receptor 2	695	TIR.				cellular response to diacyl bacterial lipopeptide|cellular response to lipoteichoic acid|cellular response to triacyl bacterial lipopeptide|detection of diacyl bacterial lipopeptide|detection of triacyl bacterial lipopeptide|I-kappaB phosphorylation|induction of apoptosis|inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway|positive regulation of chemokine production|positive regulation of interferon-beta production|positive regulation of interleukin-12 production|positive regulation of interleukin-18 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of toll-like receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|positive regulation of Wnt receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	cytoplasm|integral to plasma membrane|Toll-like receptor 1-Toll-like receptor 2 protein complex	Gram-positive bacterial cell surface binding|lipopolysaccharide receptor activity|peptidoglycan binding|protein heterodimerization activity|transmembrane receptor activity|triacyl lipopeptide binding			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(6)|lung(11)|ovary(1)|pancreas(1)|skin(1)|urinary_tract(1)	29	all_hematologic(180;0.093)	Renal(120;0.117)				CCATTGAAAAGAGCCACAAAA	0.423000													20	129					0	0	1	0	0
NFKBID	84807	broad.mit.edu	37	19	36380797	36380797	+	Missense_Mutation	SNP	C	C	G			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr19:36380797C>G	ENST00000396901.1	-	11	1456	c.883G>C	c.(883-885)Gag>Cag	p.E295Q	NFKBID_ENST00000340950.2_Missense_Mutation_p.E132Q|NFKBID_ENST00000606253.1_Missense_Mutation_p.E295Q|NFKBID_ENST00000352614.2_Missense_Mutation_p.E447Q	NM_139239.1	NP_640332.1	Q8NI38	IKBD_HUMAN	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, delta	295					inflammatory response	nucleus				breast(1)|cervix(1)|endometrium(2)|large_intestine(2)|lung(6)|ovary(1)|urinary_tract(1)	14						CTTACCCCCTCAGGGCCCGGC	0.672000													37	85					0	0	1	0	0
ZFYVE9	9372	broad.mit.edu	37	1	52704141	52704141	+	Missense_Mutation	SNP	G	G	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr1:52704141G>A	ENST00000287727.3	+	4	1224	c.1052G>A	c.(1051-1053)aGg>aAg	p.R351K	ZFYVE9_ENST00000361625.1_Missense_Mutation_p.R351K|ZFYVE9_ENST00000371591.1_Missense_Mutation_p.R351K|ZFYVE9_ENST00000357206.2_Missense_Mutation_p.R351K	NM_004799.2	NP_004790.2	O95405	ZFYV9_HUMAN	zinc finger, FYVE domain containing 9	351					endocytosis|SMAD protein complex assembly|SMAD protein import into nucleus|transforming growth factor beta receptor signaling pathway	early endosome membrane	metal ion binding|protein binding|receptor activity|serine-type peptidase activity			breast(1)|central_nervous_system(4)|endometrium(3)|kidney(1)|large_intestine(12)|lung(17)|ovary(2)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(6)	53						GGGTCTGGAAGGAATAATGAC	0.443000													26	73					0	0	1	0	0
PHF14	9678	broad.mit.edu	37	7	11022739	11022739	+	Nonsense_Mutation	SNP	G	G	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr7:11022739G>T	ENST00000403050.3	+	3	1305	c.853G>T	c.(853-855)Gaa>Taa	p.E285*	PHF14_ENST00000445996.2_Intron	NM_014660.3	NP_055475.2	O94880	PHF14_HUMAN	PHD finger protein 14	285							zinc ion binding			NS(2)|breast(1)|endometrium(4)|kidney(5)|large_intestine(5)|lung(14)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	35				UCEC - Uterine corpus endometrioid carcinoma (126;0.205)		TGATGATGAGGAACTGACCAA	0.423000													10	40					0.00829132	0.00866021	1	1	0
KCNH7	90134	broad.mit.edu	37	2	163393469	163393469	+	Missense_Mutation	SNP	C	C	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr2:163393469C>A	ENST00000332142.5	-	3	528	c.429G>T	c.(427-429)agG>agT	p.R143S	KCNH7_ENST00000328032.4_Missense_Mutation_p.R143S	NM_033272.3	NP_150375.2	Q9NS40	KCNH7_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 7	143	PAC.				regulation of transcription, DNA-dependent	integral to membrane	protein binding|signal transducer activity			NS(1)|biliary_tract(1)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(22)|lung(53)|ovary(3)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(3)	108					Ibutilide(DB00308)	TTGGGTTTACCCTCTCTGGGG	0.383000													14	115					0.000308642	0.000336266	1	1	0
PTPN4	5775	broad.mit.edu	37	2	120725513	120725513	+	Missense_Mutation	SNP	A	A	G			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr2:120725513A>G	ENST00000263708.2	+	26	3430	c.2659A>G	c.(2659-2661)Atg>Gtg	p.M887V	PTPN4_ENST00000544261.1_Missense_Mutation_p.M520V	NM_002830.3	NP_002821.1	P29074	PTN4_HUMAN	protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte)	887	Tyrosine-protein phosphatase.					cytoplasm|cytoskeleton|internal side of plasma membrane	cytoskeletal protein binding|non-membrane spanning protein tyrosine phosphatase activity			endometrium(3)|kidney(2)|large_intestine(7)|lung(15)|ovary(2)|urinary_tract(1)	30					Alendronate(DB00630)	TGTAAGAACAATGAGAGATCA	0.378000													35	72					0	0	1	0	0
LRSAM1	90678	broad.mit.edu	37	9	130242172	130242172	+	Missense_Mutation	SNP	G	G	C	rs71497658		TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr9:130242172G>C	ENST00000323301.4	+	13	1562	c.958G>C	c.(958-960)Gag>Cag	p.E320Q	LRSAM1_ENST00000373322.1_Missense_Mutation_p.E320Q|LRSAM1_ENST00000300417.6_Missense_Mutation_p.E320Q|LRSAM1_ENST00000373324.4_Missense_Mutation_p.E320Q|LRSAM1_ENST00000483302.1_3'UTR	NM_138361.5	NP_612370.3	Q6UWE0	LRSM1_HUMAN	leucine rich repeat and sterile alpha motif containing 1	320					negative regulation of endocytosis|non-lytic virus budding|protein autoubiquitination|protein catabolic process|protein polyubiquitination|protein transport|ubiquitin-dependent endocytosis	cytoplasm|extracellular region|membrane part	hormone activity|ubiquitin-protein ligase activity|zinc ion binding			central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(6)|ovary(2)	16						CCTCAACGCAGAGCGGCAGCG	0.652000													11	55					0	0	1	0	0
CNTN3	5067	broad.mit.edu	37	3	74414807	74414807	+	Silent	SNP	C	C	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr3:74414807C>A	ENST00000263665.6	-	8	1020	c.993G>T	c.(991-993)gtG>gtT	p.V331V		NM_020872.1	NP_065923.1	Q9P232	CNTN3_HUMAN	contactin 3 (plasmacytoma associated)	331	Ig-like C2-type 4.				cell adhesion	anchored to membrane|plasma membrane	protein binding			NS(2)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(39)|ovary(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	83		Lung NSC(201;0.138)|Lung SC(41;0.21)		Epithelial(33;0.00212)|BRCA - Breast invasive adenocarcinoma(55;0.00258)|LUSC - Lung squamous cell carcinoma(21;0.00461)|Lung(16;0.01)		GACTGTCCTCCACGGCTATTT	0.453000													31	247					5.60225e-13	7.73644e-13	1	1	0
ELTD1	64123	broad.mit.edu	37	1	79404910	79404910	+	Missense_Mutation	SNP	A	A	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr1:79404910A>T	ENST00000370742.3	-	4	422	c.359T>A	c.(358-360)gTc>gAc	p.V120D		NM_022159.3	NP_071442.2	Q9HBW9	ELTD1_HUMAN	EGF, latrophilin and seven transmembrane domain containing 1	120					neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(1)|breast(1)|endometrium(3)|kidney(2)|large_intestine(10)|lung(45)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	69				COAD - Colon adenocarcinoma(225;0.0905)|Colorectal(170;0.103)|all cancers(265;0.105)|Epithelial(280;0.148)		AGCTATACAGACATTATCTAA	0.239000													17	24					0	0	1	0	0
AKAP5	9495	broad.mit.edu	37	14	64935338	64935338	+	Silent	SNP	C	C	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr14:64935338C>A	ENST00000320636.5	+	1	1514	c.226C>A	c.(226-228)Cgg>Agg	p.R76R	ZBTB25_ENST00000555424.1_Intron|ZBTB25_ENST00000555220.1_Intron|AKAP5_ENST00000394718.3_Silent_p.R76R			P24588	AKAP5_HUMAN	A kinase (PRKA) anchor protein 5	76	AKAP.|Essential to the intracellular anchoring function (By similarity).				energy reserve metabolic process|positive regulation of cAMP biosynthetic process|positive regulation of protein kinase A signaling cascade|protein targeting|regulation of insulin secretion|signal transduction|synaptic transmission	cytosol	adenylate cyclase binding|calmodulin binding			endometrium(2)|kidney(1)|large_intestine(5)|lung(4)|stomach(1)	13				all cancers(60;0.00749)|OV - Ovarian serous cystadenocarcinoma(108;0.0095)|BRCA - Breast invasive adenocarcinoma(234;0.0449)		AGAGCCCACACGGGGGGCCTG	0.537000													38	61					1.90571e-15	2.71536e-15	1	1	0
CDH3	1001	broad.mit.edu	37	16	68721553	68721553	+	Missense_Mutation	SNP	A	A	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr16:68721553A>T	ENST00000264012.4	+	12	2253	c.1709A>T	c.(1708-1710)aAg>aTg	p.K570M	CDH3_ENST00000429102.2_Missense_Mutation_p.K570M|CDH3_ENST00000581171.1_Missense_Mutation_p.K515M	NM_001793.4	NP_001784.2	P22223	CADH3_HUMAN	cadherin 3, type 1, P-cadherin (placental)	570	Cadherin 5.				adherens junction organization|cell junction assembly|homophilic cell adhesion|response to stimulus|visual perception	integral to membrane	calcium ion binding	p.?(2)		NS(1)|breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(4)|ovary(3)|skin(1)|urinary_tract(1)	25		Ovarian(137;0.0564)		OV - Ovarian serous cystadenocarcinoma(108;0.000782)|Epithelial(162;0.0054)|all cancers(182;0.0384)		ATCACGGACAAGGACCTGTCT	0.567000													25	114					0	0	1	0	0
GDF5	8200	broad.mit.edu	37	20	34025254	34025254	+	Missense_Mutation	SNP	G	G	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr20:34025254G>A	ENST00000374372.1	-	3	958	c.455C>T	c.(454-456)cCc>cTc	p.P152L	GDF5_ENST00000374369.3_Missense_Mutation_p.P152L			P43026	GDF5_HUMAN	growth differentiation factor 5	152					cartilage development|cell-cell signaling|growth|transforming growth factor beta receptor signaling pathway	extracellular space	cytokine activity|growth factor activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(3)|lung(9)|skin(3)	26	Lung NSC(9;0.00642)|all_lung(11;0.0094)		BRCA - Breast invasive adenocarcinoma(18;0.00663)			TGGGGGCCCGGGCTCCCTGGC	0.642000													28	66					0	0	1	0	0
CLRN2	645104	broad.mit.edu	37	4	17524557	17524557	+	Silent	SNP	C	C	G			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr4:17524557C>G	ENST00000511148.2	+	2	426	c.324C>G	c.(322-324)gcC>gcG	p.A108A		NM_001079827.2	NP_001073296.1	A0PK11	CLRN2_HUMAN	clarin 2	108						integral to membrane				breast(1)|kidney(1)|large_intestine(3)|lung(8)|pancreas(1)|upper_aerodigestive_tract(1)	15						TCTTCCTGGCCTTGGCCCTGG	0.567000													13	102					0	0	1	0	0
MADD	8567	broad.mit.edu	37	11	47307014	47307014	+	Silent	SNP	G	G	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr11:47307014G>T	ENST00000342922.4	+	14	2781	c.2424G>T	c.(2422-2424)ctG>ctT	p.L808L	MADD_ENST00000406482.1_Silent_p.L765L|MADD_ENST00000407859.3_Silent_p.L765L|MADD_ENST00000402192.2_Silent_p.L808L|MADD_ENST00000395336.3_Silent_p.L808L|MADD_ENST00000395344.3_Silent_p.L765L|MADD_ENST00000349238.3_Silent_p.L808L|MADD_ENST00000311027.5_Silent_p.L808L|MADD_ENST00000402799.1_Silent_p.L765L	NM_130470.2	NP_569826.2	Q8WXG6	MADD_HUMAN	MAP-kinase activating death domain	808					activation of MAPK activity|apoptosis|cell surface receptor linked signaling pathway|regulation of apoptosis|regulation of cell cycle	cytoplasm|integral to membrane|plasma membrane	death receptor binding|protein kinase activator activity|Rab guanyl-nucleotide exchange factor activity			breast(7)|central_nervous_system(2)|endometrium(9)|kidney(3)|large_intestine(19)|lung(26)|ovary(6)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(2)	84				Lung(87;0.182)		CTCAAAAGCTGCTGCGGCCCA	0.552000													32	121					1.1423e-28	1.73813e-28	1	1	0
MUC5B	727897	broad.mit.edu	37	11	1268816	1268816	+	Missense_Mutation	SNP	C	C	T	rs71469871		TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr11:1268816C>T	ENST00000447027.1	+	31	10773	c.10715C>T	c.(10714-10716)aCg>aTg	p.T3572M	RP11-532E4.2_ENST00000532061.2_RNA|MUC5B_ENST00000529681.1_Missense_Mutation_p.T3569M			Q9HC84	MUC5B_HUMAN	mucin 5B, oligomeric mucus/gel-forming	3569	7 X Cys-rich subdomain repeats.|Thr-rich.			Missing (in Ref. 6; AAB61398).	cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding			cervix(2)|endometrium(36)|kidney(9)|lung(89)|urinary_tract(1)	137		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		GTGGTGACCACGGGCTGTGAG	0.657000													9	53					0	0	1	0	0
SPZ1	84654	broad.mit.edu	37	5	79616984	79616984	+	Nonsense_Mutation	SNP	T	T	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr5:79616984T>A	ENST00000296739.4	+	1	1195	c.950T>A	c.(949-951)tTg>tAg	p.L317*		NM_032567.3	NP_115956.3	Q9BXG8	SPZ1_HUMAN	spermatogenic leucine zipper 1	317	Leucine-zipper.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding			endometrium(2)|kidney(5)|large_intestine(4)|lung(12)|ovary(1)|skin(2)	26		Lung NSC(167;0.0393)|all_lung(232;0.0428)|Ovarian(174;0.113)		OV - Ovarian serous cystadenocarcinoma(54;3.43e-47)|Epithelial(54;2.25e-41)|all cancers(79;4.19e-36)		ACCTATTCATTGCAGTTGATG	0.443000													11	66					0	0	1	0	0
NPR1	4881	broad.mit.edu	37	1	153661697	153661697	+	Silent	SNP	G	G	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr1:153661697G>T	ENST00000368680.3	+	17	3070	c.2598G>T	c.(2596-2598)acG>acT	p.T866T		NM_000906.3	NP_000897.3	P16066	ANPRA_HUMAN	natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A)	866					body fluid secretion|intracellular signal transduction|negative regulation of angiogenesis|negative regulation of cell growth|positive regulation of renal sodium excretion|positive regulation of urine volume|receptor guanylyl cyclase signaling pathway|regulation of blood pressure|regulation of blood vessel size|regulation of vascular permeability|regulation of vasodilation		ATP binding|GTP binding|guanylate cyclase activity|natriuretic peptide receptor activity|peptide receptor activity, G-protein coupled|protein kinase activity			NS(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(8)|liver(1)|lung(17)|ovary(4)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	42	all_lung(78;3.75e-32)|Lung NSC(65;1.37e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)		Erythrityl Tetranitrate(DB01613)|Isosorbide Dinitrate(DB00883)|Isosorbide Mononitrate(DB01020)|Nesiritide(DB04899)|Nitric Oxide(DB00435)|Nitroglycerin(DB00727)|Nitroprusside(DB00325)	GTGGGGAGACGGTGCAGGCCG	0.612000													21	196					5.26018e-13	7.27424e-13	1	1	0
KIAA0319	9856	broad.mit.edu	37	6	24596512	24596512	+	Missense_Mutation	SNP	C	C	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr6:24596512C>A	ENST00000535378.1	-	4	1005	c.363G>T	c.(361-363)tgG>tgT	p.W121C	KIAA0319_ENST00000430948.2_Missense_Mutation_p.W85C|KIAA0319_ENST00000537886.1_Missense_Mutation_p.W130C|KIAA0319_ENST00000543707.1_Missense_Mutation_p.W130C|KIAA0319_ENST00000378214.3_Missense_Mutation_p.W130C	NM_001168374.1	NP_001161846.1	Q5VV43	K0319_HUMAN	KIAA0319	130					negative regulation of dendrite development|neuron migration	early endosome membrane|integral to membrane|plasma membrane	protein binding			breast(3)|endometrium(6)|kidney(3)|large_intestine(11)|lung(19)|ovary(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)	53						GTGAGTCCCCCCAGATCCCCG	0.557000													29	65					3.73988e-18	5.45492e-18	1	1	0
MEF2C	4208	broad.mit.edu	37	5	88025083	88025083	+	Missense_Mutation	SNP	G	G	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr5:88025083G>T	ENST00000504921.2	-	8	1588	c.916C>A	c.(916-918)Caa>Aaa	p.Q306K	MEF2C_ENST00000514028.1_Missense_Mutation_p.Q306K|MEF2C_ENST00000506554.1_Missense_Mutation_p.Q306K|MEF2C_ENST00000514015.1_Missense_Mutation_p.Q306K|MEF2C_ENST00000340208.5_Missense_Mutation_p.Q316K|MEF2C_ENST00000539796.1_Missense_Mutation_p.Q250K|MEF2C_ENST00000508569.1_Missense_Mutation_p.Q298K|MEF2C_ENST00000424173.2_Missense_Mutation_p.Q296K|MEF2C_ENST00000437473.2_Missense_Mutation_p.Q306K|MEF2C_ENST00000510942.1_Missense_Mutation_p.Q298K			Q06413	MEF2C_HUMAN	myocyte enhancer factor 2C	306					apoptosis|B cell proliferation|innate immune response|learning or memory|muscle cell differentiation|muscle organ development|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|nerve growth factor receptor signaling pathway|neuron development|positive regulation of muscle cell differentiation|positive regulation of survival gene product expression|positive regulation of transcription from RNA polymerase II promoter|regulation of germinal center formation|regulation of megakaryocyte differentiation|regulation of synaptic activity|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	nuclear speck	activating transcription factor binding|protein heterodimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			breast(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(9)|lung(9)|ovary(2)|pancreas(1)|prostate(4)|skin(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	40		all_cancers(142;6.67e-05)|all_epithelial(76;7.77e-07)|Lung NSC(167;0.00566)|all_lung(232;0.00732)|Colorectal(57;0.0959)|Ovarian(174;0.1)		OV - Ovarian serous cystadenocarcinoma(54;1.04e-33)|Epithelial(54;1.6e-28)|all cancers(79;2.9e-25)		CCCATTCCTTGTCCTGGTAAA	0.378000										HNSCC(66;0.2)			5	21					0.014758	0.0152052	1	1	0
SNX31	169166	broad.mit.edu	37	8	101601151	101601151	+	Silent	SNP	G	G	C			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr8:101601151G>C	ENST00000311812.2	-	11	1185	c.1035C>G	c.(1033-1035)ctC>ctG	p.L345L	SNX31_ENST00000519521.1_5'UTR|SNX31_ENST00000428383.2_Silent_p.L246L	NM_152628.3	NP_689841.3	Q8N9S9	SNX31_HUMAN	sorting nexin 31	345					cell communication|protein transport		phosphatidylinositol binding			NS(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(12)|prostate(1)|skin(3)|urinary_tract(1)	26	all_cancers(14;4.01e-05)|all_epithelial(15;1.26e-07)|Lung NSC(17;0.000453)|all_lung(17;0.00125)		Epithelial(11;1.21e-11)|all cancers(13;2.62e-09)|OV - Ovarian serous cystadenocarcinoma(57;3.22e-06)|STAD - Stomach adenocarcinoma(118;0.206)			ATTGAAATCTGAGCTCTAAGT	0.418000													11	99					0	0	1	0	0
SCYL3	57147	broad.mit.edu	37	1	169831905	169831905	+	Missense_Mutation	SNP	G	G	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr1:169831905G>A	ENST00000367772.4	-	10	1186	c.989C>T	c.(988-990)tCa>tTa	p.S330L	SCYL3_ENST00000470238.1_5'UTR|SCYL3_ENST00000367771.5_Missense_Mutation_p.S330L|SCYL3_ENST00000367770.1_Missense_Mutation_p.S330L	NM_181093.3	NP_851607.2	Q8IZE3	PACE1_HUMAN	SCY1-like 3 (S. cerevisiae)	330					cell migration	Golgi apparatus|lamellipodium	ATP binding|protein binding|protein kinase activity			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(7)|lung(5)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	27	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					CAGGGCTGGTGAGAGCAAGCA	0.463000													31	256					0	0	1	0	0
AOC2	314	broad.mit.edu	37	17	40997112	40997112	+	Missense_Mutation	SNP	G	G	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr17:40997112G>T	ENST00000253799.3	+	1	496	c.469G>T	c.(469-471)Ggc>Tgc	p.G157C	AOC2_ENST00000452774.2_Missense_Mutation_p.G157C	NM_009590.2	NP_033720.2	O75106	AOC2_HUMAN	amine oxidase, copper containing 2 (retina-specific)	157					catecholamine metabolic process|visual perception	cytoplasm|plasma membrane	aliphatic-amine oxidase activity|aminoacetone:oxygen oxidoreductase(deaminating) activity|copper ion binding|electron carrier activity|phenethylamine:oxygen oxidoreductase (deaminating) activity|primary amine oxidase activity|quinone binding|tryptamine:oxygen oxidoreductase (deaminating) activity			NS(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(14)|ovary(4)|skin(2)	30		Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.156)		GGAGCGTCACGGCGGGCCCCT	0.612000													8	61					0.000274275	0.000299485	1	1	0
MATR3	9782	broad.mit.edu	37	5	138655116	138655116	+	Missense_Mutation	SNP	G	G	C			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr5:138655116G>C	ENST00000394800.2	+	13	2077	c.1528G>C	c.(1528-1530)Gat>Cat	p.D510H	MATR3_ENST00000503811.1_Missense_Mutation_p.D222H|MATR3_ENST00000502499.1_Missense_Mutation_p.D172H|MATR3_ENST00000502929.1_Missense_Mutation_p.D510H|MATR3_ENST00000394805.3_Missense_Mutation_p.D510H|MATR3_ENST00000361059.2_Missense_Mutation_p.D510H|MATR3_ENST00000510056.1_Missense_Mutation_p.D510H|MATR3_ENST00000504203.1_Missense_Mutation_p.D172H|MATR3_ENST00000509990.1_Missense_Mutation_p.D510H			P43243	MATR3_HUMAN	matrin 3	510	RRM 2.					nuclear inner membrane|nuclear matrix	nucleotide binding|protein binding|RNA binding|structural molecule activity|zinc ion binding			breast(2)|endometrium(3)|kidney(4)|large_intestine(6)|lung(9)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	29			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00325)			TGGCTATTCTGATAGTGCTGT	0.378000													12	62					0	0	1	0	0
CLSTN3	9746	broad.mit.edu	37	12	7302131	7302131	+	Missense_Mutation	SNP	G	G	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr12:7302131G>T	ENST00000537408.1	+	13	2661	c.2123G>T	c.(2122-2124)cGc>cTc	p.R708L	CLSTN3_ENST00000266546.6_Missense_Mutation_p.R696L			Q9BQT9	CSTN3_HUMAN	calsyntenin 3	696					homophilic cell adhesion	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|plasma membrane	calcium ion binding			NS(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(12)|lung(7)|prostate(1)|skin(1)	33						ACAGACACACGCATGTCGGAT	0.577000													17	44					1.99824e-07	2.43543e-07	1	1	0
GMPS	8833	broad.mit.edu	37	3	155643029	155643029	+	Splice_Site	SNP	G	G	C			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr3:155643029G>C	ENST00000496455.1	+	12	1769		c.e12-1		GMPS_ENST00000295920.7_Splice_Site	NM_003875.2	NP_003866.1	P49915	GUAA_HUMAN	guanine monphosphate synthase						glutamine metabolic process|purine base biosynthetic process	cytosol	ATP binding|GMP synthase (glutamine-hydrolyzing) activity|GMP synthase activity			breast(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(5)|lung(12)|ovary(2)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	32			Lung(72;0.11)|LUSC - Lung squamous cell carcinoma(72;0.114)		L-Glutamic Acid(DB00142)|L-Glutamine(DB00130)	GTTTTTCTCAGCCACATACCC	0.368000			T	MLL	AML								5	44					0	0	1	0	0
OLFML2B	25903	broad.mit.edu	37	1	161989751	161989751	+	Silent	SNP	G	G	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr1:161989751G>A	ENST00000294794.3	-	2	819	c.396C>T	c.(394-396)ttC>ttT	p.F132F	OLFML2B_ENST00000367940.2_Silent_p.F132F	NM_015441.1	NP_056256.1	Q68BL8	OLM2B_HUMAN	olfactomedin-like 2B	132										breast(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(11)|lung(22)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	48	all_hematologic(112;0.156)		BRCA - Breast invasive adenocarcinoma(70;0.0172)			TCTGGAGCCTGAAGTCTCCCT	0.572000													6	52					0	0	1	0	0
SLC9B1	150159	broad.mit.edu	37	4	103822407	103822407	+	Missense_Mutation	SNP	A	A	G			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr4:103822407A>G	ENST00000296422.7	-	12	1556	c.1415T>C	c.(1414-1416)gTa>gCa	p.V472A	SLC9B1_ENST00000394789.3_Intron|SLC9B1_ENST00000512651.2_5'UTR	NM_139173.3	NP_631912.2	Q4ZJI4	NHDC1_HUMAN	solute carrier family 9, subfamily B (NHA1, cation proton antiporter 1), member 1	472						integral to membrane	solute:hydrogen antiporter activity										TAAAAATGCTACTGTCATCAC	0.458000													20	281					0	0	1	0	0
PCNT	5116	broad.mit.edu	37	21	47783678	47783678	+	Missense_Mutation	SNP	C	C	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr21:47783678C>T	ENST00000359568.5	+	14	2545	c.2438C>T	c.(2437-2439)tCc>tTc	p.S813F	PCNT_ENST00000480896.1_3'UTR	NM_006031.5	NP_006022.3	O95613	PCNT_HUMAN	pericentrin	813					cilium assembly|G2/M transition of mitotic cell cycle	cytosol|microtubule	calmodulin binding			NS(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(15)|liver(2)|lung(41)|ovary(5)|pancreas(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	104	Breast(49;0.112)					CTGGAGAGGTCCTTGACGGAG	0.592000													26	123					0	0	1	0	0
OR5AS1	219447	broad.mit.edu	37	11	55798635	55798635	+	Silent	SNP	A	A	G			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr11:55798635A>G	ENST00000313555.1	+	1	741	c.741A>G	c.(739-741)gcA>gcG	p.A247A		NM_001001921.1	NP_001001921.1	Q8N127	O5AS1_HUMAN	olfactory receptor, family 5, subfamily AS, member 1	247					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(7)|large_intestine(7)|liver(1)|lung(22)|ovary(3)|prostate(4)|skin(3)|stomach(1)	48	Esophageal squamous(21;0.00693)					ACCTCATAGCAGTCACCTTAT	0.443000													12	84					0	0	1	0	0
SERPINB8	5271	broad.mit.edu	37	18	61652390	61652390	+	Missense_Mutation	SNP	G	G	C			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr18:61652390G>C	ENST00000397985.2	+	6	887	c.631G>C	c.(631-633)Gta>Cta	p.V211L	SERPINB8_ENST00000353706.2_Missense_Mutation_p.V211L|SERPINB8_ENST00000542677.1_Missense_Mutation_p.V29L|SERPINB8_ENST00000397988.3_Missense_Mutation_p.V211L	NM_001276490.1	NP_001263419.1	P50452	SPB8_HUMAN	serpin peptidase inhibitor, clade B (ovalbumin), member 8	211					regulation of proteolysis	cytosol	protein binding|serine-type endopeptidase inhibitor activity			breast(2)|kidney(1)|large_intestine(4)|lung(9)|skin(1)	17		Esophageal squamous(42;0.129)				TGCGGATGAGGTACACACCCA	0.473000													10	42					0	0	1	0	0
ARID1B	57492	broad.mit.edu	37	6	157528564	157528564	+	Missense_Mutation	SNP	G	G	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr6:157528564G>A	ENST00000346085.5	+	20	6290	c.6289G>A	c.(6289-6291)Gac>Aac	p.D2097N	ARID1B_ENST00000275248.4_Missense_Mutation_p.D2079N|ARID1B_ENST00000350026.5_Missense_Mutation_p.D2084N|ARID1B_ENST00000367148.1_Missense_Mutation_p.D2137N	NM_020732.3	NP_065783.3	Q8NFD5	ARI1B_HUMAN	AT rich interactive domain 1B (SWI1-like)	2084					chromatin-mediated maintenance of transcription|nervous system development|transcription, DNA-dependent	SWI/SNF complex	DNA binding|protein binding|transcription coactivator activity			NS(2)|breast(5)|central_nervous_system(4)|endometrium(12)|kidney(4)|large_intestine(11)|lung(30)|ovary(3)|pancreas(1)|prostate(4)|skin(2)|urinary_tract(3)	81		Breast(66;0.000162)|Ovarian(120;0.0265)		OV - Ovarian serous cystadenocarcinoma(65;3.19e-17)|BRCA - Breast invasive adenocarcinoma(81;1.01e-05)		CAATAATGTGGACCTGATCTT	0.483000													41	260					0	0	1	0	0
NOL4	8715	broad.mit.edu	37	18	31538378	31538378	+	Missense_Mutation	SNP	G	G	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr18:31538378G>T	ENST00000261592.5	-	7	1358	c.1061C>A	c.(1060-1062)cCt>cAt	p.P354H	NOL4_ENST00000535384.1_Missense_Mutation_p.P69H|NOL4_ENST00000589544.1_Missense_Mutation_p.P354H|NOL4_ENST00000535475.1_Missense_Mutation_p.P199H|NOL4_ENST00000269185.4_Missense_Mutation_p.P240H|NOL4_ENST00000538587.1_Missense_Mutation_p.P280H	NM_001198546.1|NM_003787.4	NP_001185475.1|NP_003778.2	O94818	NOL4_HUMAN	nucleolar protein 4	354						nucleolus	RNA binding			NS(1)|breast(2)|endometrium(6)|kidney(1)|large_intestine(7)|lung(20)|ovary(4)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	51						ACTATGTGCAGGAGACTGAAA	0.388000													29	122					1.17739e-12	1.61237e-12	1	1	0
MPPED2	744	broad.mit.edu	37	11	30517017	30517017	+	Missense_Mutation	SNP	G	G	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr11:30517017G>A	ENST00000448418.2	-	4	722	c.362C>T	c.(361-363)aCa>aTa	p.T121I	MPPED2_ENST00000358117.5_Missense_Mutation_p.T121I	NM_001145399.1	NP_001138871.1	Q15777	MPPD2_HUMAN	metallophosphoesterase domain containing 2	121					nervous system development		hydrolase activity|metal ion binding			NS(1)|breast(2)|endometrium(4)|kidney(2)|large_intestine(4)|liver(1)|lung(15)|skin(2)|upper_aerodigestive_tract(2)	33						CTTATCAAATGTCAGTTCATG	0.393000													12	50					0	0	1	0	0
SPATA31D1	389763	broad.mit.edu	37	9	84609969	84609969	+	Missense_Mutation	SNP	C	C	G			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr9:84609969C>G	ENST00000344803.2	+	4	4631	c.4584C>G	c.(4582-4584)aaC>aaG	p.N1528K		NM_001001670.2	NP_001001670.1			SPATA31 subfamily D, member 1																		CACATCCAAACCCCACTTGCC	0.537000													7	23					0	0	1	0	0
MYO3B	140469	broad.mit.edu	37	2	171375953	171375953	+	Missense_Mutation	SNP	A	A	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr2:171375953A>T	ENST00000334231.6	+	30	3505	c.3505A>T	c.(3505-3507)Agg>Tgg	p.R1169W	MYO3B_ENST00000409044.3_Missense_Mutation_p.R1133W|MYO3B_ENST00000408978.4_Missense_Mutation_p.R1160W|MYO3B_ENST00000602629.1_3'UTR			Q8WXR4	MYO3B_HUMAN	myosin IIIB	1160					response to stimulus|visual perception	cytoplasm|myosin complex	actin binding|ATP binding|motor activity|protein serine/threonine kinase activity			breast(1)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(25)|ovary(6)|pancreas(1)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	59						CTCAGTTCTCAGGGGCTCTGT	0.488000													4	45					0	0	1	0	0
PIWIL4	143689	broad.mit.edu	37	11	94330997	94330997	+	Missense_Mutation	SNP	G	G	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr11:94330997G>T	ENST00000299001.6	+	11	1507	c.1296G>T	c.(1294-1296)gaG>gaT	p.E432D	RP11-867G2.8_ENST00000537874.1_RNA|RP11-867G2.8_ENST00000536540.1_RNA	NM_152431.2	NP_689644.2	Q7Z3Z4	PIWL4_HUMAN	piwi-like RNA-mediated gene silencing 4	432					cell differentiation|DNA methylation involved in gamete generation|gene silencing by RNA|meiosis|multicellular organismal development|piRNA metabolic process|regulation of translation|spermatogenesis	nucleus|piP-body	piRNA binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(9)|lung(10)|prostate(1)|skin(1)|urinary_tract(2)	30		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.0123)				TTGAACTAGAGACCTGGGGAC	0.378000													7	53					5.68852e-11	7.60012e-11	1	1	0
SCN8A	6334	broad.mit.edu	37	12	52080928	52080928	+	Missense_Mutation	SNP	G	G	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr12:52080928G>T	ENST00000354534.5	+	5	717	c.539G>T	c.(538-540)aGa>aTa	p.R180I	SCN8A_ENST00000545061.1_Missense_Mutation_p.R180I|SCN8A_ENST00000550891.1_Missense_Mutation_p.R180I	NM_001177984.2|NM_014191.3	NP_001171455.1|NP_055006.1	Q9UQD0	SCN8A_HUMAN	sodium channel, voltage gated, type VIII, alpha subunit	180					axon guidance|myelination|peripheral nervous system development	cytoplasmic membrane-bounded vesicle|node of Ranvier	ATP binding|voltage-gated sodium channel activity			breast(2)|central_nervous_system(1)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(19)|ovary(8)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	55				BRCA - Breast invasive adenocarcinoma(357;0.181)	Lamotrigine(DB00555)	ATCATTGCAAGAGGTTTCTGC	0.388000													7	40					0.0293803	0.0299576	1	1	0
PPARGC1B	133522	broad.mit.edu	37	5	149212622	149212622	+	Missense_Mutation	SNP	C	C	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr5:149212622C>T	ENST00000309241.5	+	5	1018	c.986C>T	c.(985-987)tCc>tTc	p.S329F	PPARGC1B_ENST00000360453.4_Missense_Mutation_p.S290F|PPARGC1B_ENST00000403750.1_Missense_Mutation_p.S265F|PPARGC1B_ENST00000394320.3_Missense_Mutation_p.S329F	NM_133263.3	NP_573570.3	Q86YN6	PRGC2_HUMAN	peroxisome proliferator-activated receptor gamma, coactivator 1 beta	329					estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter	mediator complex	AF-2 domain binding|estrogen receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|nucleotide binding|receptor activator activity|RNA binding|RNA polymerase II transcription cofactor activity			NS(1)|breast(1)|endometrium(1)|kidney(3)|large_intestine(1)|liver(2)|lung(15)|ovary(3)|prostate(2)|stomach(1)	30			KIRC - Kidney renal clear cell carcinoma(527;0.000962)|Kidney(363;0.00147)			CGGCCCTGGTCCCGGCACCAC	0.632000													40	58					0	0	1	0	0
VCL	7414	broad.mit.edu	37	10	75849105	75849105	+	Nonsense_Mutation	SNP	C	C	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr10:75849105C>T	ENST00000211998.4	+	9	1268	c.1174C>T	c.(1174-1176)Cag>Tag	p.Q392*	VCL_ENST00000372755.3_Nonsense_Mutation_p.Q392*|VCL_ENST00000417648.2_Intron|VCL_ENST00000478896.2_Intron	NM_014000.2	NP_054706.1	P18206	VINC_HUMAN	vinculin	392	3 X 112 AA tandem repeats.|N-terminal globular head.				adherens junction assembly|apical junction assembly|cell-matrix adhesion|cellular component movement|epithelial cell-cell adhesion|lamellipodium assembly|morphogenesis of an epithelium|muscle contraction|negative regulation of cell migration|platelet activation|platelet degranulation|protein localization at cell surface	costamere|cytosol|extracellular region|focal adhesion	actin binding|alpha-catenin binding|beta-catenin binding|beta-dystroglycan binding|cadherin binding|structural molecule activity		VCL/ALK(4)	breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(3)|lung(8)|ovary(2)|upper_aerodigestive_tract(1)	20	Prostate(51;0.0112)					CGATGCTGCTCAGGTAGTCAC	0.423000													10	37					0	0	1	0	0
PCDHB6	56130	broad.mit.edu	37	5	140531995	140531995	+	Silent	SNP	G	G	C			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr5:140531995G>C	ENST00000231136.1	+	1	2157	c.2157G>C	c.(2155-2157)tcG>tcC	p.S719S	PCDHB6_ENST00000543635.1_Silent_p.S583S	NM_018939.2	NP_061762.1	Q9Y5E3	PCDB6_HUMAN		719					calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			cervix(1)|endometrium(14)|kidney(6)|large_intestine(16)|liver(1)|lung(33)|ovary(1)|pancreas(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	84			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GGGCGGCCTCGGTGGGTCGCT	0.647000													49	221					0	0	1	0	0
CNKSR2	22866	broad.mit.edu	37	X	21627366	21627366	+	Missense_Mutation	SNP	C	C	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chrX:21627366C>T	ENST00000425654.2	+	19	2713	c.2233C>T	c.(2233-2235)Cca>Tca	p.P745S	CNKSR2_ENST00000379510.3_Missense_Mutation_p.P775S|CNKSR2_ENST00000279451.4_Missense_Mutation_p.P775S|CNKSR2_ENST00000543067.1_Missense_Mutation_p.P726S	NM_001168647.1	NP_001162118.1	Q8WXI2	CNKR2_HUMAN	connector enhancer of kinase suppressor of Ras 2	775					regulation of signal transduction	cytoplasm|membrane	protein binding			breast(3)|endometrium(8)|kidney(2)|large_intestine(15)|lung(28)|prostate(2)|upper_aerodigestive_tract(3)	61						AATTGAGACGCCACTGACAAG	0.562000													24	52					0	0	1	0	0
ZNF91	7644	broad.mit.edu	37	19	23544935	23544935	+	Silent	SNP	A	A	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr19:23544935A>T	ENST00000300619.7	-	4	1051	c.846T>A	c.(844-846)acT>acA	p.T282T	ZNF91_ENST00000397082.2_Silent_p.T250T|ZNF91_ENST00000599743.1_Intron	NM_003430.2	NP_003421.2	Q05481	ZNF91_HUMAN	zinc finger protein 91	282						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding						all_lung(12;0.0349)|Lung NSC(12;0.0538)|all_epithelial(12;0.0611)				TCTTATGTCTAGTTAGGGTTG	0.383000													7	85					0	0	1	0	0
A1CF	29974	broad.mit.edu	37	10	52566525	52566525	+	Silent	SNP	T	T	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr10:52566525T>A	ENST00000395489.2	-	15	2124	c.1728A>T	c.(1726-1728)gcA>gcT	p.A576A	A1CF_ENST00000374001.1_Silent_p.A575A|A1CF_ENST00000395495.1_Silent_p.A528A|A1CF_ENST00000373993.1_Silent_p.A583A|A1CF_ENST00000373995.3_Silent_p.A583A|A1CF_ENST00000373997.3_Silent_p.A575A|A1CF_ENST00000282641.2_Silent_p.A583A|ASAH2B_ENST00000483649.1_Intron	NM_001198819.1	NP_001185748.1	Q9NQ94	A1CF_HUMAN	APOBEC1 complementation factor	583					cytidine to uridine editing|mRNA modification|mRNA processing|protein stabilization	apolipoprotein B mRNA editing enzyme complex|endoplasmic reticulum|nucleoplasm	nucleotide binding|protein binding|single-stranded RNA binding			NS(1)|breast(1)|central_nervous_system(1)|kidney(3)|large_intestine(4)|lung(14)|prostate(2)|skin(3)	29						GGGCAGTCACTGCAAAAGTTG	0.413000													13	71					0	0	1	0	0
SSPN	8082	broad.mit.edu	37	12	26377295	26377295	+	Missense_Mutation	SNP	A	A	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr12:26377295A>T	ENST00000242729.2	+	2	526	c.349A>T	c.(349-351)Att>Ttt	p.I117F	RP11-283G6.4_ENST00000540392.1_RNA|SSPN_ENST00000535504.1_Missense_Mutation_p.I117F|SSPN_ENST00000540266.1_Missense_Mutation_p.I14F|SSPN_ENST00000422622.2_Missense_Mutation_p.I14F	NM_005086.4	NP_005077.2	Q14714	SSPN_HUMAN	sarcospan	117					cell adhesion|muscle contraction	cell junction|dystrophin-associated glycoprotein complex|integral to plasma membrane|postsynaptic membrane|sarcolemma|transport vesicle				kidney(1)|large_intestine(2)|lung(5)|skin(1)|stomach(1)	10	Colorectal(261;0.0847)					ACGGACATGTATTCAATTTTC	0.378000													30	175					0	0	1	0	0
CYP11B2	1585	broad.mit.edu	37	8	143999173	143999173	+	Silent	SNP	G	G	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr8:143999173G>T	ENST00000323110.2	-	1	86	c.84C>A	c.(82-84)gcC>gcA	p.A28A		NM_000498.3	NP_000489.3	P19099	C11B2_HUMAN	cytochrome P450, family 11, subfamily B, polypeptide 2	28					aldosterone biosynthetic process|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|potassium ion homeostasis|regulation of blood volume by renal aldosterone|sodium ion homeostasis|xenobiotic metabolic process		corticosterone 18-monooxygenase activity|electron carrier activity|steroid 11-beta-monooxygenase activity			cervix(1)|endometrium(2)|kidney(3)|large_intestine(5)|lung(22)|ovary(3)|upper_aerodigestive_tract(3)	39	all_cancers(97;5.56e-11)|all_epithelial(106;2.49e-08)|Lung NSC(106;0.000228)|all_lung(105;0.000633)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)				Candesartan(DB00796)|Metyrapone(DB01011)	GGGCCCGAGCGGCTCTAGTGC	0.647000									Familial Hyperaldosteronism type I				14	142					2.31682e-05	2.62573e-05	1	1	0
HBD	3045	broad.mit.edu	37	11	5255395	5255395	+	Silent	SNP	C	C	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr11:5255395C>T	ENST00000380299.3	-	2	355	c.141G>A	c.(139-141)ggG>ggA	p.G47G	HBD_ENST00000292901.3_Silent_p.G47G	NM_000519.3	NP_000510.1	P02042	HBD_HUMAN	hemoglobin, delta	47					blood coagulation	hemoglobin complex	heme binding|oxygen binding|oxygen transporter activity			endometrium(2)|large_intestine(3)|lung(9)|ovary(1)|prostate(1)	16		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;5.69e-10)|BRCA - Breast invasive adenocarcinoma(625;0.135)		AGGACAGATCCCCAAAGGACT	0.527000													29	94					0	0	1	0	0
GRIN2B	2904	broad.mit.edu	37	12	13717339	13717339	+	Missense_Mutation	SNP	C	C	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr12:13717339C>T	ENST00000279593.3	-	13	3042	c.2833G>A	c.(2833-2835)Gac>Aac	p.D945N		NM_000834.3	NP_000825.2	Q13224	NMDE2_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 2B	945					response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	glycine binding|N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(5)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(12)|liver(1)|lung(70)|ovary(4)|prostate(6)|skin(10)|upper_aerodigestive_tract(5)|urinary_tract(1)	143					Felbamate(DB00949)|Haloperidol(DB00502)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	GATTTGCAGTCAGAATGCGTG	0.557000													49	142					0	0	1	0	0
GIMAP2	26157	broad.mit.edu	37	7	150389780	150389780	+	Missense_Mutation	SNP	G	G	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr7:150389780G>T	ENST00000223293.5	+	3	500	c.406G>T	c.(406-408)Gat>Tat	p.D136Y		NM_015660.2	NP_056475.1	Q9UG22	GIMA2_HUMAN	GTPase, IMAP family member 2	136						integral to membrane	GTP binding			kidney(1)|large_intestine(1)|lung(8)|skin(2)|urinary_tract(1)	13			OV - Ovarian serous cystadenocarcinoma(82;0.0145)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		CTTTGGAGAGGATGCCATGGG	0.542000													19	34					6.94344e-10	9.02007e-10	1	1	0
FMO4	2329	broad.mit.edu	37	1	171292287	171292287	+	Nonsense_Mutation	SNP	G	G	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr1:171292287G>T	ENST00000367749.3	+	4	607	c.277G>T	c.(277-279)Gaa>Taa	p.E93*	FMO4_ENST00000462992.1_3'UTR	NM_002022.1	NP_002013.1	P31512	FMO4_HUMAN	flavin containing monooxygenase 4	93					xenobiotic metabolic process	integral to membrane|intrinsic to endoplasmic reticulum membrane|microsome	flavin adenine dinucleotide binding|flavin-containing monooxygenase activity|NADP binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(12)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	33	all_cancers(6;3.9e-08)|all_hematologic(923;0.088)|Acute lymphoblastic leukemia(37;0.181)					CTATCTCCAAGAATTTGCTGA	0.383000													8	71					1.06961e-07	1.31665e-07	1	1	0
ABCB1	5243	broad.mit.edu	37	7	87170749	87170749	+	Missense_Mutation	SNP	T	T	G			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr7:87170749T>G	ENST00000265724.3	-	19	2660	c.2243A>C	c.(2242-2244)aAa>aCa	p.K748T	ABCB1_ENST00000543898.1_Missense_Mutation_p.K684T	NM_000927.4	NP_000918.2	P08183	MDR1_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 1	748	ABC transmembrane type-1 2.				G2/M transition of mitotic cell cycle|stem cell proliferation	apical plasma membrane|cell surface|Golgi membrane|integral to membrane|intercellular canaliculus|membrane fraction	ATP binding|protein binding|xenobiotic-transporting ATPase activity			NS(1)|breast(6)|central_nervous_system(2)|endometrium(14)|kidney(9)|large_intestine(14)|lung(48)|ovary(4)|prostate(6)|skin(6)|upper_aerodigestive_tract(1)	111	Esophageal squamous(14;0.00164)				Adenosine triphosphate(DB00171)|Alfentanil(DB00802)|Arsenic trioxide(DB01169)|Atazanavir(DB01072)|Carvedilol(DB01136)|Colchicine(DB01394)|Cyclosporine(DB00091)|Daunorubicin(DB00694)|Dipyridamole(DB00975)|Estramustine(DB01196)|Flupenthixol(DB00875)|Imatinib(DB00619)|Itraconazole(DB01167)|Nicardipine(DB00622)|Propafenone(DB01182)|Quinacrine(DB01103)|Quinidine(DB00908)|Ranolazine(DB00243)|Rifampin(DB01045)|Roxithromycin(DB00778)|Saquinavir(DB01232)|Tamoxifen(DB00675)|Vinblastine(DB00570)	ATTCTGTCGTTTTGTTTCAGG	0.323000													8	54					0	0	1	0	0
SLC1A7	6512	broad.mit.edu	37	1	53554646	53554646	+	Missense_Mutation	SNP	C	C	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr1:53554646C>A	ENST00000371494.4	-	10	1494	c.1367G>T	c.(1366-1368)cGt>cTt	p.R456L	SLC1A7_ENST00000488036.1_5'UTR	NM_006671.4	NP_006662.3	O00341	EAA5_HUMAN	solute carrier family 1 (glutamate transporter), member 7	456						integral to membrane|plasma membrane	high-affinity glutamate transmembrane transporter activity|sodium:dicarboxylate symporter activity			NS(1)|breast(3)|endometrium(3)|kidney(2)|large_intestine(4)|lung(8)|ovary(2)|prostate(1)|skin(1)|stomach(1)	26				Colorectal(1306;0.234)	L-Glutamic Acid(DB00142)	GGTGCGGAAACGGTCCCTGGT	0.612000													10	59					0.00621372	0.00651779	1	1	0
WDR3	10885	broad.mit.edu	37	1	118492655	118492655	+	Missense_Mutation	SNP	G	G	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr1:118492655G>A	ENST00000349139.4	+	15	1695	c.1648G>A	c.(1648-1650)Gaa>Aaa	p.E550K		NM_006784.2	NP_006775.1	Q9UNX4	WDR3_HUMAN	WD repeat domain 3	550						nuclear membrane|nucleolus				breast(2)|cervix(2)|endometrium(5)|kidney(4)|large_intestine(9)|liver(2)|lung(22)|prostate(2)|upper_aerodigestive_tract(1)	49	Esophageal squamous(2;0.162)	all_cancers(81;2.72e-05)|Acute lymphoblastic leukemia(138;1e-08)|all_epithelial(167;4.4e-07)|all_lung(203;1.7e-06)|Lung NSC(69;1.98e-05)|Prostate(1639;0.00955)|Breast(1374;0.244)		OV - Ovarian serous cystadenocarcinoma(397;1.39e-08)|Epithelial(280;1.82e-07)|all cancers(265;2.04e-05)|Lung(183;0.0525)|BRCA - Breast invasive adenocarcinoma(282;0.0695)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.185)		GCAACTAGATGAAGATGTTCT	0.358000													49	135					0	0	1	0	0
GRIA1	2890	broad.mit.edu	37	5	153144051	153144051	+	Silent	SNP	C	C	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr5:153144051C>A	ENST00000285900.5	+	12	2224	c.1881C>A	c.(1879-1881)atC>atA	p.I627I	GRIA1_ENST00000340592.5_Silent_p.I627I|GRIA1_ENST00000518142.1_Silent_p.I547I|GRIA1_ENST00000521843.2_Silent_p.I558I|GRIA1_ENST00000518783.1_Silent_p.I637I|GRIA1_ENST00000448073.4_Silent_p.I637I	NM_000827.3|NM_001258019.1	NP_000818.2|NP_001244948.1	P42261	GRIA1_HUMAN	glutamate receptor, ionotropic, AMPA 1	627					synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|dendritic spine|endocytic vesicle membrane|endoplasmic reticulum membrane|neuronal cell body|postsynaptic density|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity|PDZ domain binding			NS(1)|breast(4)|endometrium(7)|kidney(3)|large_intestine(24)|liver(2)|lung(23)|ovary(4)|pancreas(1)|prostate(5)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	81		Medulloblastoma(196;0.0391)|all_neural(177;0.16)|all_hematologic(541;0.21)	Kidney(363;0.000173)|KIRC - Kidney renal clear cell carcinoma(527;0.000785)		Desflurane(DB01189)|Enflurane(DB00228)|Halothane(DB01159)|Isoflurane(DB00753)|L-Glutamic Acid(DB00142)|Methoxyflurane(DB01028)|Sevoflurane(DB01236)	TAATCATCATCTCCTCATATA	0.542000													13	60					0.0167234	0.0172122	1	1	0
OR2G2	81470	broad.mit.edu	37	1	247752598	247752598	+	Missense_Mutation	SNP	G	G	C			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr1:247752598G>C	ENST00000320065.1	+	1	937	c.937G>C	c.(937-939)Gga>Cga	p.G313R	RP11-978I15.10_ENST00000435333.1_RNA|RP11-978I15.10_ENST00000446347.1_RNA	NM_001001915.1	NP_001001915.1	Q8NGZ5	OR2G2_HUMAN	olfactory receptor, family 2, subfamily G, member 2	313					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.G313R(1)		endometrium(4)|kidney(4)|large_intestine(3)|lung(30)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	45	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.017)			AAAGGCTCTGGGAGtaaatat	0.318000													30	80					0	0	1	0	0
SULT1E1	6783	broad.mit.edu	37	4	70715155	70715155	+	Splice_Site	SNP	C	C	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr4:70715155C>A	ENST00000226444.3	-	5	608	c.496_splice	c.e5+1	p.V166_splice		NM_005420.2	NP_005411.1	P49888	ST1E1_HUMAN	sulfotransferase family 1E, estrogen-preferring, member 1	166					3'-phosphoadenosine 5'-phosphosulfate metabolic process|sulfation|xenobiotic metabolic process	cytosol|nuclear membrane	estrone sulfotransferase activity|flavonol 3-sulfotransferase activity|steroid binding|steroid sulfotransferase activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(2)|ovary(1)|prostate(1)|skin(1)	10						CTGTTCCTACCCTGTCCTTGC	0.378000													6	43					0.00198382	0.00210327	1	1	0
A2ML1	144568	broad.mit.edu	37	12	9013486	9013486	+	Missense_Mutation	SNP	G	G	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr12:9013486G>T	ENST00000299698.7	+	27	3454	c.3274G>T	c.(3274-3276)Gat>Tat	p.D1092Y	A2ML1_ENST00000539547.1_Missense_Mutation_p.D601Y	NM_144670.4	NP_653271.2	B3KVV6	B3KVV6_HUMAN	alpha-2-macroglobulin-like 1	936						extracellular space	endopeptidase inhibitor activity			NS(2)|breast(5)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|liver(2)|lung(36)|ovary(2)|skin(4)|stomach(1)|urinary_tract(1)	80						GGGTGGTGTTGATGATGAGGT	0.517000											OREG0021663	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	10	105					2.80697e-09	3.60844e-09	1	1	0
DUSP27	92235	broad.mit.edu	37	1	167096921	167096921	+	Missense_Mutation	SNP	G	G	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr1:167096921G>T	ENST00000361200.2	+	6	2719	c.2553G>T	c.(2551-2553)atG>atT	p.M851I	DUSP27_ENST00000443333.1_Missense_Mutation_p.M851I|DUSP27_ENST00000485151.1_Intron|DUSP27_ENST00000271385.5_Missense_Mutation_p.M851I			Q5VZP5	DUS27_HUMAN	dual specificity phosphatase 27 (putative)	851					protein dephosphorylation		protein tyrosine/serine/threonine phosphatase activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(11)|liver(1)|lung(46)|ovary(5)|prostate(5)|skin(4)|upper_aerodigestive_tract(3)	89						GGGAGAAGATGTCTGAGTACA	0.498000													36	36					4.65686e-17	6.70316e-17	1	1	0
OPN1MW	2652	broad.mit.edu	37	X	153458999	153458999	+	Missense_Mutation	SNP	G	G	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chrX:153458999G>A	ENST00000369935.5	+	5	905	c.845G>A	c.(844-846)gGa>gAa	p.G282E	OPN1MW_ENST00000468495.1_3'UTR	NM_000513.2	NP_000504.1	P04001	OPSG_HUMAN	opsin 1 (cone pigments), medium-wave-sensitive	282					phototransduction|protein-chromophore linkage|visual perception	integral to plasma membrane	G-protein coupled receptor activity|photoreceptor activity			endometrium(1)|lung(1)	2	all_cancers(53;1.83e-16)|all_epithelial(53;2.73e-10)|all_lung(58;6.39e-07)|Lung NSC(58;8.37e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					TTCTGCTGGGGACCATACGCC	0.572000													37	136					0	0	1	0	0
HMGA2	8091	broad.mit.edu	37	12	66308894	66308894	+	Missense_Mutation	SNP	C	C	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr12:66308894C>A	ENST00000354636.3	+	4	1116	c.305C>A	c.(304-306)aCc>aAc	p.T102N	AC090673.2_ENST00000601398.1_Intron|HMGA2_ENST00000393577.3_Intron|HMGA2_ENST00000536545.1_3'UTR|HMGA2_ENST00000403681.2_Intron|HMGA2_ENST00000541363.1_Intron	NM_003484.1	NP_003475.1	P52926	HMGA2_HUMAN	high mobility group AT-hook 2	102					cell division|chromatin organization|mitosis|multicellular organismal development|regulation of growth|transcription, DNA-dependent	chromatin	AT DNA binding		HMGA2/RAD51B(11)|HMGA2/CCNB1IP1(2)|HMGA2/WIF1_ENST00000286574(14)|HMGA2/ALDH2_ENST00000261733(2)|HMGA2/EBF1(2)|HMGA2/LHFP(2)|HMGA2/NFIB_ENST00000397581(8)|HMGA2/LPP(161)|HMGA2/FHIT_ENST00000476844(4)|HMGA2/COX6C(2)	lung(2)	2	all_cancers(1;5.78e-46)		GBM - Glioblastoma multiforme(1;0.00179)|LUSC - Lung squamous cell carcinoma(43;0.156)	GBM - Glioblastoma multiforme(28;0.0386)		GGAAACAGTACCAAAAGGAGT	0.423000			T	""" LHFP, RAD51L1, LPP, COX6C, CMKOR1, NFIB, ALDH2, CCNB1IP1, EBF1, WIF1, FHIT"""	"""lipoma, leiomyoma, pleiomorphic salivary gland adenoma"""								14	115					0.000151284	0.000166666	1	1	0
RNF133	168433	broad.mit.edu	37	7	122338136	122338136	+	Missense_Mutation	SNP	G	G	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr7:122338136G>T	ENST00000340112.2	-	1	1074	c.837C>A	c.(835-837)caC>caA	p.H279Q	CADPS2_ENST00000334010.7_Intron|CADPS2_ENST00000313070.7_Intron|CADPS2_ENST00000449022.2_Intron|CADPS2_ENST00000412584.2_Intron	NM_139175.1	NP_631914.1	Q8WVZ7	RN133_HUMAN	ring finger protein 133	279						endoplasmic reticulum membrane|integral to membrane	ligase activity|zinc ion binding			NS(1)|biliary_tract(1)|breast(1)|central_nervous_system(1)|large_intestine(3)|lung(11)|ovary(1)|skin(1)|urinary_tract(1)	21						TGCAATTCTTGTGGAAAAAAT	0.373000													59	66					2.69953e-25	4.06373e-25	1	1	0
KRTAP4-11	653240	broad.mit.edu	37	17	39274291	39274291	+	Missense_Mutation	SNP	T	T	C	rs149439944	by1000genomes	TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr17:39274291T>C	ENST00000391413.2	-	1	315	c.277A>G	c.(277-279)Atg>Gtg	p.M93V		NM_033059.3	NP_149048.2	Q9BYQ6	KR411_HUMAN	keratin associated protein 4-11	93	27 X 5 AA repeats of C-C-[GIKRQVHEL]- [SPTR]-[STVQRMC].					keratin filament		p.M93V(4)		endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|lung(8)|prostate(5)|skin(1)	33		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000371)			TGGCAGCACATAGACTGGCAG	0.662000													9	66					0	0	1	0	0
DSG1	1828	broad.mit.edu	37	18	28911790	28911790	+	Missense_Mutation	SNP	C	C	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr18:28911790C>A	ENST00000257192.4	+	6	856	c.644C>A	c.(643-645)aCt>aAt	p.T215N		NM_001942.2	NP_001933.2	Q02413	DSG1_HUMAN	desmoglein 1	215	Cadherin 2.				calcium-dependent cell-cell adhesion|cell-cell junction assembly|cellular component disassembly involved in apoptosis|homophilic cell adhesion|protein stabilization	cytosol|desmosome|integral to membrane|internal side of plasma membrane	calcium ion binding|gamma-catenin binding|toxin binding			NS(2)|central_nervous_system(2)|endometrium(5)|kidney(7)|large_intestine(11)|lung(36)|ovary(3)|prostate(1)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)	76			OV - Ovarian serous cystadenocarcinoma(10;0.00559)			AACAGAAATACTGGAGAAATT	0.338000													11	42					3.07112e-06	3.59634e-06	1	1	0
NFATC1	4772	broad.mit.edu	37	18	77170431	77170431	+	Silent	SNP	C	C	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr18:77170431C>T	ENST00000253506.5	+	2	525	c.156C>T	c.(154-156)gtC>gtT	p.V52V	NFATC1_ENST00000542384.1_Silent_p.V52V|NFATC1_ENST00000586434.1_Silent_p.V39V|NFATC1_ENST00000427363.2_Silent_p.V52V|NFATC1_ENST00000397790.2_Intron|NFATC1_ENST00000587635.1_Silent_p.V52V|NFATC1_ENST00000318065.5_Silent_p.V39V|NFATC1_ENST00000329101.4_Silent_p.V39V|NFATC1_ENST00000545796.1_Intron|NFATC1_ENST00000591814.1_Silent_p.V52V|NFATC1_ENST00000592223.1_Silent_p.V39V	NM_006162.3	NP_006153.2	O95644	NFAC1_HUMAN	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1	52					intracellular signal transduction|positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|nucleus	FK506 binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			NS(2)|breast(1)|endometrium(7)|kidney(1)|large_intestine(4)|lung(17)|ovary(2)|prostate(4)|skin(1)|soft_tissue(1)	40		Esophageal squamous(42;0.0157)|Melanoma(33;0.144)		OV - Ovarian serous cystadenocarcinoma(15;3.73e-07)|BRCA - Breast invasive adenocarcinoma(31;0.0257)		CCTCCAACGTCAGCCCCGCCC	0.622000													32	153					0	0	1	0	0
CSF2	1437	broad.mit.edu	37	5	131409791	131409791	+	Silent	SNP	C	C	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr5:131409791C>T	ENST00000296871.2	+	2	211	c.177C>T	c.(175-177)gtC>gtT	p.V59V		NM_000758.3	NP_000749.2	P04141	CSF2_HUMAN	colony stimulating factor 2 (granulocyte-macrophage)	59					immune response|negative regulation of cytolysis|positive regulation of DNA replication|positive regulation of interleukin-23 production|positive regulation of macrophage derived foam cell differentiation|positive regulation of podosome assembly|positive regulation of tyrosine phosphorylation of Stat5 protein	extracellular space	cytokine activity|granulocyte macrophage colony-stimulating factor receptor binding|growth factor activity			skin(1)	1		all_cancers(142;4.28e-07)|all_lung(232;2.81e-05)|Lung NSC(810;0.000693)|Lung SC(612;0.122)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)		Sargramostim(DB00020)	CAGTAGAAGTCATCTCAGAAA	0.517000													12	58					0	0	1	0	0
RCHY1	25898	broad.mit.edu	37	4	76434498	76434498	+	Silent	SNP	G	G	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr4:76434498G>A	ENST00000324439.5	-	2	497	c.99C>T	c.(97-99)tgC>tgT	p.C33C	RCHY1_ENST00000451788.1_Silent_p.C33C|RCHY1_ENST00000512706.1_Silent_p.C11C|RCHY1_ENST00000513257.1_Silent_p.C33C|RCHY1_ENST00000514021.1_5'UTR|RCHY1_ENST00000380840.2_Intron	NM_001278536.1|NM_001278538.1|NM_001278539.1	NP_001265465.1|NP_001265467.1|NP_001265468.1	Q96PM5	ZN363_HUMAN	ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase	33					positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein ubiquitination|protein autoubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nuclear speck|ubiquitin ligase complex	electron carrier activity|p53 binding|protein homodimerization activity|ubiquitin-protein ligase activity|zinc ion binding			large_intestine(2)|pancreas(1)	3			Lung(101;0.0973)|LUSC - Lung squamous cell carcinoma(112;0.122)			GCTTGTCACAGCAAGGTGCCT	0.388000													4	15					0	0	1	0	0
PRPF4B	8899	broad.mit.edu	37	6	4052197	4052197	+	Missense_Mutation	SNP	G	G	C			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr6:4052197G>C	ENST00000337659.6	+	10	2281	c.2181G>C	c.(2179-2181)aaG>aaC	p.K727N	PRPF4B_ENST00000538861.1_Missense_Mutation_p.K713N	NM_003913.4	NP_003904.3	Q13523	PRP4B_HUMAN	pre-mRNA processing factor 4B	727	Protein kinase.					catalytic step 2 spliceosome	ATP binding|protein binding|protein serine/threonine kinase activity			breast(6)|endometrium(3)|large_intestine(5)|lung(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	22	Ovarian(93;0.0925)	all_hematologic(90;0.0895)				TTAGGCAAAAGACTGGTTTAA	0.328000													10	21					0	0	1	0	0
RENBP	5973	broad.mit.edu	37	X	153209828	153209828	+	Missense_Mutation	SNP	G	G	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chrX:153209828G>A	ENST00000412763.1	-	2	239	c.70C>T	c.(70-72)Cgc>Tgc	p.R24C	RENBP_ENST00000369997.3_Missense_Mutation_p.R24C|RENBP_ENST00000393700.3_Missense_Mutation_p.R24C			P51606	RENBP_HUMAN	renin binding protein	24					mannose metabolic process|regulation of blood pressure		endopeptidase inhibitor activity|mannose-6-phosphate isomerase activity|N-acylglucosamine 2-epimerase activity			breast(1)|endometrium(3)|kidney(2)|large_intestine(1)|lung(7)|ovary(2)|pancreas(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	20	all_cancers(53;6.72e-15)|all_epithelial(53;3.19e-09)|all_lung(58;3.39e-06)|all_hematologic(71;4.25e-06)|Lung NSC(58;4.7e-06)|Acute lymphoblastic leukemia(192;6.56e-05)				N-Acetyl-D-glucosamine(DB00141)	TGCCCCACGCGCTCCTTCCAG	0.657000													26	74					0	0	1	0	0
VPS13B	157680	broad.mit.edu	37	8	100168787	100168787	+	Missense_Mutation	SNP	A	A	C			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr8:100168787A>C	ENST00000395996.1	+	15	2135	c.2024A>C	c.(2023-2025)aAc>aCc	p.N675T	VPS13B_ENST00000355155.1_Missense_Mutation_p.N675T|VPS13B_ENST00000358544.2_Missense_Mutation_p.N675T|VPS13B_ENST00000357162.2_Missense_Mutation_p.N675T			Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13 homolog B (yeast)	675					protein transport					NS(1)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(37)|lung(78)|ovary(8)|pancreas(3)|prostate(5)|skin(9)|upper_aerodigestive_tract(4)|urinary_tract(9)	193	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			AACTCAAGTAACTTCATGAAT	0.378000													14	75					0	0	1	0	0
OR6T1	219874	broad.mit.edu	37	11	123814219	123814219	+	Silent	SNP	G	G	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr11:123814219G>T	ENST00000321252.2	-	1	361	c.327C>A	c.(325-327)acC>acA	p.T109T		NM_001005187.1	NP_001005187.1	Q8NGN1	OR6T1_HUMAN	olfactory receptor, family 6, subfamily T, member 1	109					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(18)|ovary(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	40		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0401)		AGAAGTCAGTGGTGCCTAGAA	0.522000													9	58					7.48243e-07	8.91024e-07	1	1	0
PLCD4	84812	broad.mit.edu	37	2	219483373	219483373	+	Missense_Mutation	SNP	C	C	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr2:219483373C>T	ENST00000450993.2	+	4	592	c.253C>T	c.(253-255)Ctc>Ttc	p.L85F	PLCD4_ENST00000417849.1_Missense_Mutation_p.L85F|PLCD4_ENST00000432688.1_Missense_Mutation_p.L85F	NM_032726.3	NP_116115.1	Q9BRC7	PLCD4_HUMAN	phospholipase C, delta 4	85	PH.				intracellular signal transduction|lipid catabolic process	endoplasmic reticulum|membrane|nucleus	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(2)|lung(7)|ovary(3)|prostate(1)|urinary_tract(3)	23		Renal(207;0.0915)		Epithelial(149;5.11e-07)|all cancers(144;0.000104)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)		GGCAGAGGAGCTCCCCCTGGA	0.562000													8	36					0	0	1	0	0
C5	727	broad.mit.edu	37	9	123776293	123776293	+	Silent	SNP	A	A	C			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr9:123776293A>C	ENST00000223642.1	-	17	2144	c.2115T>G	c.(2113-2115)gtT>gtG	p.V705V		NM_001735.2	NP_001726.2	P01031	CO5_HUMAN	complement component 5	705	Anaphylatoxin-like.				activation of MAPK activity|chemotaxis|complement activation, alternative pathway|complement activation, classical pathway|cytolysis|G-protein coupled receptor protein signaling pathway|inflammatory response|negative regulation of macrophage chemotaxis|positive regulation of chemokine secretion|positive regulation vascular endothelial growth factor production	extracellular space|membrane attack complex	chemokine activity|endopeptidase inhibitor activity			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(14)|lung(5)|ovary(2)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	46				OV - Ovarian serous cystadenocarcinoma(323;4.98e-53)|GBM - Glioblastoma multiforme(294;0.0242)	Eculizumab(DB01257)	CATCATTATTAACGCAGGCTC	0.433000													19	69					0	0	1	0	0
TBX4	9496	broad.mit.edu	37	17	59544956	59544956	+	Missense_Mutation	SNP	C	C	T	rs141536152		TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr17:59544956C>T	ENST00000393853.4	+	5	650	c.487C>T	c.(487-489)Cgg>Tgg	p.R163W	TBX4_ENST00000240335.1_Missense_Mutation_p.R163W			P57082	TBX4_HUMAN	T-box 4	163					leg morphogenesis|skeletal system morphogenesis	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity	p.R163W(1)		breast(1)|endometrium(1)|kidney(2)|large_intestine(6)|liver(2)|lung(15)|ovary(4)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	40						CCACTGGATGCGGCAGCTGGT	0.612000													16	39					0	0	1	0	0
COL6A3	1293	broad.mit.edu	37	2	238242168	238242168	+	Missense_Mutation	SNP	G	G	C			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr2:238242168G>C	ENST00000295550.4	-	42	9705	c.9253C>G	c.(9253-9255)Cag>Gag	p.Q3085E	COL6A3_ENST00000347401.3_Missense_Mutation_p.Q2884E|COL6A3_ENST00000346358.4_Missense_Mutation_p.Q2885E|COL6A3_ENST00000472056.1_Missense_Mutation_p.Q2478E|COL6A3_ENST00000409809.1_Missense_Mutation_p.Q2879E|COL6A3_ENST00000353578.4_Missense_Mutation_p.Q2879E	NM_004369.3	NP_004360.2	P12111	CO6A3_HUMAN	collagen, type VI, alpha 3	3085	Nonhelical region.				axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			breast(6)|central_nervous_system(7)|cervix(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(13)|large_intestine(64)|lung(62)|ovary(14)|pancreas(2)|prostate(11)|skin(14)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(4)	217		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		CTTGCTGGCTGTGGAGGTGGG	0.428000													5	58					0	0	1	0	0
ANKRD55	79722	broad.mit.edu	37	5	55422859	55422859	+	Missense_Mutation	SNP	C	C	G			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr5:55422859C>G	ENST00000341048.4	-	8	838	c.687G>C	c.(685-687)gaG>gaC	p.E229D	ANKRD55_ENST00000504958.2_Missense_Mutation_p.E186D|ANKRD55_ENST00000505970.2_Intron	NM_024669.2	NP_078945.2	Q3KP44	ANR55_HUMAN	ankyrin repeat domain 55	228										breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(7)|lung(17)|ovary(1)|prostate(1)|skin(2)|stomach(1)	34		Lung NSC(810;8.69e-05)|Prostate(74;0.00634)|Breast(144;0.0334)|Ovarian(174;0.223)				TCTTCCCACTCTCATCATCAT	0.498000													22	90					0	0	1	0	0
SVIL	6840	broad.mit.edu	37	10	29747233	29747233	+	Nonsense_Mutation	SNP	G	G	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr10:29747233G>T	ENST00000375398.2	-	40	7037	c.6588C>A	c.(6586-6588)taC>taA	p.Y2196*	PTCHD3P1_ENST00000430295.1_RNA|PTCHD3P1_ENST00000446807.1_RNA|PTCHD3P1_ENST00000438202.1_RNA|PTCHD3P1_ENST00000413405.1_RNA|PTCHD3P1_ENST00000423223.1_RNA|SVIL_ENST00000535393.1_Nonsense_Mutation_p.Y1110*|SVIL_ENST00000355867.4_Nonsense_Mutation_p.Y2196*|PTCHD3P1_ENST00000455774.1_RNA|PTCHD3P1_ENST00000445521.1_RNA|PTCHD3P1_ENST00000414457.1_RNA|SVIL_ENST00000375400.3_Nonsense_Mutation_p.Y1770*			O95425	SVIL_HUMAN	supervillin	2196	HP.				cytoskeleton organization|skeletal muscle tissue development	cell junction|costamere|invadopodium|nucleus|podosome	actin filament binding			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(17)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(24)|lung(35)|ovary(8)|prostate(2)|skin(4)|stomach(7)|upper_aerodigestive_tract(2)|urinary_tract(2)	112		Breast(68;0.103)				GCAGGGCGTTGTATTCATCCC	0.572000													24	92					5.35356e-11	7.17202e-11	1	1	0
SMCR8	140775	broad.mit.edu	37	17	18219775	18219775	+	Missense_Mutation	SNP	T	T	G			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr17:18219775T>G	ENST00000406438.3	+	1	1152	c.672T>G	c.(670-672)ttT>ttG	p.F224L		NM_144775.2	NP_658988.2	Q8TEV9	SMCR8_HUMAN	Smith-Magenis syndrome chromosome region, candidate 8	224										breast(1)|central_nervous_system(1)|endometrium(3)|kidney(4)|large_intestine(1)|lung(7)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	21						ACAAAGGCTTTTACTCATCTC	0.463000													9	24					0	0	1	0	0
ADRBK1	156	broad.mit.edu	37	11	67052428	67052428	+	Nonsense_Mutation	SNP	G	G	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr11:67052428G>T	ENST00000308595.5	+	19	2055	c.1765G>T	c.(1765-1767)Gag>Tag	p.E589*	ADRBK1_ENST00000527176.1_3'UTR|ADRBK1_ENST00000526285.1_Intron	NM_001619.3	NP_001610.2	P25098	ARBK1_HUMAN	adrenergic, beta, receptor kinase 1	589	PH.				activation of phospholipase C activity|cardiac muscle contraction|desensitization of G-protein coupled receptor protein signaling pathway|muscarinic acetylcholine receptor signaling pathway|negative regulation of striated muscle contraction|negative regulation of the force of heart contraction by chemical signal|nerve growth factor receptor signaling pathway|peptidyl-serine phosphorylation|positive regulation of catecholamine secretion|tachykinin receptor signaling pathway	cytosol|soluble fraction	alpha-2A adrenergic receptor binding|ATP binding|beta-adrenergic receptor kinase activity|Edg-2 lysophosphatidic acid receptor binding|G-protein coupled receptor kinase activity|signal transducer activity			cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(2)|liver(2)|lung(8)|prostate(2)	22			BRCA - Breast invasive adenocarcinoma(15;2.26e-06)		Adenosine triphosphate(DB00171)	CAACCGCCTCGAGTGGCGGGG	0.692000													4	21					1.58986e-06	1.87737e-06	1	1	0
BTBD3	22903	broad.mit.edu	37	20	11903467	11903467	+	Missense_Mutation	SNP	C	C	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr20:11903467C>T	ENST00000405977.1	+	5	1347	c.722C>T	c.(721-723)aCc>aTc	p.T241I	BTBD3_ENST00000254977.3_Missense_Mutation_p.T180I|BTBD3_ENST00000378226.2_Missense_Mutation_p.T241I|BTBD3_ENST00000488503.1_3'UTR|BTBD3_ENST00000399006.2_Missense_Mutation_p.T180I			Q9Y2F9	BTBD3_HUMAN	BTB (POZ) domain containing 3	241										breast(2)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(2)|lung(18)|ovary(3)|skin(2)	34						CCAGACCTGACCCAGCGTTGC	0.537000													31	105					0	0	1	0	0
LILRA1	11024	broad.mit.edu	37	19	55106333	55106333	+	Missense_Mutation	SNP	C	C	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr19:55106333C>A	ENST00000453777.1	+	4	444	c.274C>A	c.(274-276)Cac>Aac	p.H92N	LILRB1_ENST00000418536.2_Intron|LILRB1_ENST00000396321.2_Intron|LILRA1_ENST00000473156.1_3'UTR|LILRA1_ENST00000251372.3_Missense_Mutation_p.H92N|LILRB1_ENST00000448689.1_Intron	NM_001278318.1	NP_001265247.1	O75019	LIRA1_HUMAN	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1	92	Ig-like C2-type 1.				cell surface receptor linked signaling pathway|defense response|regulation of immune response	integral to membrane|plasma membrane	antigen binding|transmembrane receptor activity			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(5)|liver(1)|lung(23)|ovary(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)	47				GBM - Glioblastoma multiforme(193;0.0348)		CACCTGGGAACACACAGGGCG	0.562000													48	75					9.58827e-17	1.37814e-16	1	1	0
OTOGL	283310	broad.mit.edu	37	12	80626846	80626846	+	Silent	SNP	C	C	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr12:80626846C>T	ENST00000458043.2	+	8	765	c.759C>T	c.(757-759)gaC>gaT	p.D253D	OTOGL_ENST00000547103.1_Silent_p.D253D	NM_173591.3	NP_775862.3			otogelin-like											breast(1)|endometrium(3)|kidney(2)|large_intestine(2)|lung(14)|prostate(1)	23						ACTACAATGACATTCAATCTG	0.428000													12	16					0	0	1	0	0
MC3R	4159	broad.mit.edu	37	20	54824514	54824514	+	Silent	SNP	C	C	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr20:54824514C>A	ENST00000243911.2	+	1	727	c.615C>A	c.(613-615)acC>acA	p.T205T		NM_019888.3	NP_063941.3	P41968	MC3R_HUMAN	melanocortin 3 receptor	242					activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|positive regulation of cAMP biosynthetic process	integral to plasma membrane	melanocyte-stimulating hormone receptor activity|neuropeptide binding|protein binding			breast(2)|endometrium(1)|kidney(3)|large_intestine(3)|lung(13)|ovary(3)|skin(1)	26			Colorectal(105;0.202)			TCATGGGCACCCTCTACGTGC	0.582000													20	104					0.000132079	0.000145834	1	1	0
CYP11B2	1585	broad.mit.edu	37	8	143999174	143999174	+	Missense_Mutation	SNP	G	G	T	rs143027239		TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr8:143999174G>T	ENST00000323110.2	-	1	85	c.83C>A	c.(82-84)gCc>gAc	p.A28D		NM_000498.3	NP_000489.3	P19099	C11B2_HUMAN	cytochrome P450, family 11, subfamily B, polypeptide 2	28					aldosterone biosynthetic process|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|potassium ion homeostasis|regulation of blood volume by renal aldosterone|sodium ion homeostasis|xenobiotic metabolic process		corticosterone 18-monooxygenase activity|electron carrier activity|steroid 11-beta-monooxygenase activity			cervix(1)|endometrium(2)|kidney(3)|large_intestine(5)|lung(22)|ovary(3)|upper_aerodigestive_tract(3)	39	all_cancers(97;5.56e-11)|all_epithelial(106;2.49e-08)|Lung NSC(106;0.000228)|all_lung(105;0.000633)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)				Candesartan(DB00796)|Metyrapone(DB01011)	GGCCCGAGCGGCTCTAGTGCC	0.647000									Familial Hyperaldosteronism type I				14	141					2.31682e-05	2.62573e-05	1	1	0
HTR4	3360	broad.mit.edu	37	5	147830794	147830794	+	Missense_Mutation	SNP	T	T	C			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr5:147830794T>C	ENST00000354217.2	-	7	1281	c.1118A>G	c.(1117-1119)aAa>aGa	p.K373R	HTR4_ENST00000314512.6_3'UTR|HTR4_ENST00000521735.1_3'UTR|HTR4_ENST00000521530.1_Missense_Mutation_p.K373R			Q13639	5HT4R_HUMAN	5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled	0					G-protein signaling, coupled to cyclic nucleotide second messenger|positive regulation of cell proliferation	endosome|integral to plasma membrane|membrane fraction	serotonin receptor activity			endometrium(5)|kidney(1)|large_intestine(3)|lung(7)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	21			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)		Cisapride(DB00604)|Rizatriptan(DB00953)|Tegaserod(DB01079)|Zolmitriptan(DB00315)	TATGGGCAGTTTCTCGAGTTC	0.473000													16	127					0	0	1	0	0
BRINP3	339479	broad.mit.edu	37	1	190250792	190250792	+	Missense_Mutation	SNP	G	G	C	rs142073525		TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr1:190250792G>C	ENST00000367462.3	-	3	556	c.325C>G	c.(325-327)Cgc>Ggc	p.R109G	FAM5C_ENST00000484105.1_Intron|RP11-547I7.1_ENST00000452178.1_RNA|FAM5C_ENST00000534846.1_Intron	NM_199051.1	NP_950252.1	Q76B58	FAM5C_HUMAN		109						extracellular region				NS(1)|breast(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(6)|kidney(8)|large_intestine(18)|lung(98)|ovary(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(7)|urinary_tract(2)	164	Prostate(682;0.198)					CTTATGTTGCGGAAGAATTCA	0.448000													37	45					0	0	1	0	0
MSL3P1	151507	broad.mit.edu	37	2	234775669	234775669	+	RNA	SNP	G	G	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr2:234775669G>A	ENST00000438684.1	-	0	445					NR_024322.1																						CTCATTGGCTGAAAAGGCTGC	0.448000													16	87					0	0	1	0	0
C17orf47	284083	broad.mit.edu	37	17	56620110	56620110	+	Missense_Mutation	SNP	C	C	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr17:56620110C>T	ENST00000321691.3	-	1	1619	c.1438G>A	c.(1438-1440)Gca>Aca	p.A480T	RP11-112H10.4_ENST00000578022.1_RNA|RP11-112H10.4_ENST00000580769.1_RNA|RP11-112H10.4_ENST00000580589.1_RNA	NM_001038704.2	NP_001033793.2	Q8NEP4	CQ047_HUMAN	chromosome 17 open reading frame 47	480										NS(1)|breast(2)|endometrium(1)|kidney(4)|large_intestine(4)|lung(9)|prostate(1)|skin(1)|urinary_tract(1)	24	Medulloblastoma(34;0.127)|all_neural(34;0.237)					GATAGGCTTGCCTTCTCTCTC	0.478000													81	228					0	0	1	0	0
C6	729	broad.mit.edu	37	5	41149362	41149362	+	Nonsense_Mutation	SNP	A	A	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr5:41149362A>T	ENST00000263413.3	-	17	2868	c.2604T>A	c.(2602-2604)taT>taA	p.Y868*	C6_ENST00000337836.5_Nonsense_Mutation_p.Y868*	NM_001115131.1	NP_001108603.2	P13671	CO6_HUMAN	complement component 6	868	C5b-binding domain.|Complement control factor I module 2.				complement activation, classical pathway|cytolysis|innate immune response	membrane attack complex	protein binding			central_nervous_system(2)|cervix(2)|endometrium(2)|kidney(7)|large_intestine(16)|liver(1)|lung(51)|ovary(3)|prostate(1)|skin(9)|upper_aerodigestive_tract(2)	96		Breast(839;1.07e-05)|Ovarian(839;0.0228)|Lung SC(612;0.0548)|Lung NSC(810;0.128)|all_neural(839;0.157)				TTTCCCAGTCATAGCAGGTGT	0.428000													70	333					0	0	1	0	0
CHD5	26038	broad.mit.edu	37	1	6190297	6190297	+	Translation_Start_Site	SNP	G	G	A	rs146316835		TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr1:6190297G>A	ENST00000378021.1	-	0	3453				CHD5_ENST00000262450.3_Silent_p.Y1118Y			Q8TDI0	CHD5_HUMAN	chromodomain helicase DNA binding protein 5						chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|DNA binding|zinc ion binding			breast(3)|central_nervous_system(3)|liver(1)|lung(1)|ovary(4)|pancreas(1)|skin(1)|upper_aerodigestive_tract(2)	16	Ovarian(185;0.0634)	all_cancers(23;5.36e-32)|all_epithelial(116;2.32e-17)|all_neural(13;3.68e-06)|all_lung(118;3.94e-06)|all_hematologic(16;2.39e-05)|Lung NSC(185;5.33e-05)|Acute lymphoblastic leukemia(12;0.000372)|Glioma(11;0.00127)|Renal(390;0.00188)|Colorectal(325;0.00342)|Breast(487;0.00373)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.15)		Epithelial(90;3.08e-37)|GBM - Glioblastoma multiforme(13;1.36e-31)|OV - Ovarian serous cystadenocarcinoma(86;7.7e-19)|Colorectal(212;9.97e-08)|COAD - Colon adenocarcinoma(227;1.07e-05)|Kidney(185;6.16e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.00109)|BRCA - Breast invasive adenocarcinoma(365;0.0012)|STAD - Stomach adenocarcinoma(132;0.00346)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.193)		AGTCCGAGTCGTAGATGATGA	0.642000													11	49					0	0	1	0	0
SLC12A1	6557	broad.mit.edu	37	15	48537039	48537039	+	Missense_Mutation	SNP	G	G	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr15:48537039G>T	ENST00000396577.3	+	11	1605	c.1390G>T	c.(1390-1392)Ggc>Tgc	p.G464C	SLC12A1_ENST00000558405.1_Missense_Mutation_p.G464C|SLC12A1_ENST00000380993.3_Missense_Mutation_p.G464C	NM_001184832.1	NP_001171761.1	Q13621	S12A1_HUMAN	solute carrier family 12 (sodium/potassium/chloride transporter), member 1	464					potassium ion transport|sodium ion transport	integral to membrane|membrane fraction	sodium:potassium:chloride symporter activity			NS(2)|breast(3)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(14)|lung(30)|ovary(1)|prostate(2)|skin(1)	59		all_lung(180;0.00219)		all cancers(107;1.76e-09)|GBM - Glioblastoma multiforme(94;1.48e-06)	Bumetanide(DB00887)|Chlormerodrin(DB00534)|Chlorthalidone(DB00310)|Ethacrynic acid(DB00903)|Furosemide(DB00695)|Hydroflumethiazide(DB00774)|Methyclothiazide(DB00232)|Metolazone(DB00524)|Potassium Chloride(DB00761)|Torasemide(DB00214)|Trichlormethiazide(DB01021)	ATGTGGGTTGGGCTATGACTT	0.458000													6	31					0.00116845	0.00124685	1	1	0
OR10J3	441911	broad.mit.edu	37	1	159284174	159284174	+	Silent	SNP	G	G	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr1:159284174G>A	ENST00000332217.5	-	1	275	c.276C>T	c.(274-276)ccC>ccT	p.P92P		NM_001004467.1	NP_001004467.1	Q5JRS4	O10J3_HUMAN	olfactory receptor, family 10, subfamily J, member 3	92					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|endometrium(7)|kidney(4)|large_intestine(7)|lung(19)|ovary(3)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	47	all_hematologic(112;0.0429)					GGGTGGCAATGGGCTGATGAG	0.498000													45	97					0	0	1	0	0
NPHS2	7827	broad.mit.edu	37	1	179530484	179530484	+	Missense_Mutation	SNP	A	A	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr1:179530484A>T	ENST00000367615.4	-	3	459	c.391T>A	c.(391-393)Tat>Aat	p.Y131N	NPHS2_ENST00000367616.4_Missense_Mutation_p.Y131N	NM_014625.2	NP_055440.1	Q9NP85	PODO_HUMAN	nephrosis 2, idiopathic, steroid-resistant (podocin)	131					excretion	integral to plasma membrane	protein binding			NS(1)|endometrium(1)|large_intestine(3)|lung(10)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)	20						ACTCTTTCATACTCTTGTACA	0.378000													49	111					0	0	1	0	0
PPP2R3A	5523	broad.mit.edu	37	3	135722317	135722317	+	Silent	SNP	G	G	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr3:135722317G>A	ENST00000264977.3	+	2	2594	c.1977G>A	c.(1975-1977)caG>caA	p.Q659Q	PPP2R3A_ENST00000490467.1_Intron	NM_001190447.1|NM_002718.4	NP_001177376.1|NP_002709.2	Q06190	P2R3A_HUMAN	protein phosphatase 2, regulatory subunit B'', alpha	659					protein dephosphorylation	protein phosphatase type 2A complex	calcium ion binding|protein binding|protein phosphatase type 2A regulator activity			breast(2)|cervix(1)|endometrium(2)|large_intestine(7)|lung(10)|ovary(3)|pancreas(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	31						TGATTCAGCAGACTCCAGAGG	0.363000													18	73					0	0	1	0	0
FLRT3	23767	broad.mit.edu	37	20	14306661	14306661	+	Missense_Mutation	SNP	C	C	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr20:14306661C>T	ENST00000378053.3	-	2	1748	c.1492G>A	c.(1492-1494)Gag>Aag	p.E498K	FLRT3_ENST00000341420.4_Missense_Mutation_p.E498K|MACROD2_ENST00000310348.4_Intron|MACROD2_ENST00000217246.4_Intron	NM_013281.3	NP_037413.1	Q9NZU0	FLRT3_HUMAN	fibronectin leucine rich transmembrane protein 3	498	Fibronectin type-III.				cell adhesion	integral to plasma membrane|proteinaceous extracellular matrix	protein binding, bridging|receptor signaling protein activity			breast(1)|kidney(2)|large_intestine(5)|lung(5)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	17		Colorectal(1;0.0464)	COAD - Colon adenocarcinoma(2;0.129)	Colorectal(1;0.0393)		GTTTCAGTCTCAATACAAACA	0.458000													17	120					0	0	1	0	0
GDF5	8200	broad.mit.edu	37	20	34022494	34022494	+	Missense_Mutation	SNP	C	C	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr20:34022494C>T	ENST00000374372.1	-	4	1222	c.719G>A	c.(718-720)cGg>cAg	p.R240Q	GDF5_ENST00000374369.3_Missense_Mutation_p.R240Q|GDF5OS_ENST00000374375.1_Missense_Mutation_p.R180C			P43026	GDF5_HUMAN	growth differentiation factor 5	240					cartilage development|cell-cell signaling|growth|transforming growth factor beta receptor signaling pathway	extracellular space	cytokine activity|growth factor activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(3)|lung(9)|skin(3)	26	Lung NSC(9;0.00642)|all_lung(11;0.0094)		BRCA - Breast invasive adenocarcinoma(18;0.00663)			CCGCAAGATCCGCAGCTCGGC	0.667000													14	148					0	0	1	0	0
MYO3B	140469	broad.mit.edu	37	2	171258165	171258165	+	Missense_Mutation	SNP	G	G	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr2:171258165G>T	ENST00000334231.6	+	18	2120	c.2120G>T	c.(2119-2121)cGc>cTc	p.R707L	MYO3B_ENST00000408978.4_Missense_Mutation_p.R698L|MYO3B_ENST00000602629.1_3'UTR|MYO3B_ENST00000409044.3_Missense_Mutation_p.R698L			Q8WXR4	MYO3B_HUMAN	myosin IIIB	698	Myosin head-like.				response to stimulus|visual perception	cytoplasm|myosin complex	actin binding|ATP binding|motor activity|protein serine/threonine kinase activity			breast(1)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(25)|ovary(6)|pancreas(1)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	59						ATTGTGAATCGCATTAATACA	0.542000													11	55					5.16669e-11	6.94053e-11	1	1	0
SNHG14	104472715	broad.mit.edu	37	15	25429470	25429470	+	RNA	SNP	C	C	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr15:25429470C>T	ENST00000424208.1	+	0	450				SNORD115-8_ENST00000363856.1_RNA	NR_003305.1																						TGATGAGAACCTTACATTGTT	0.517000													41	233					0	0	1	0	0
OTUD6A	139562	broad.mit.edu	37	X	69282900	69282900	+	Missense_Mutation	SNP	A	A	G			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chrX:69282900A>G	ENST00000338352.2	+	1	560	c.526A>G	c.(526-528)Agc>Ggc	p.S176G		NM_207320.1	NP_997203.1	Q7L8S5	OTU6A_HUMAN	OTU domain containing 6A	176	OTU.									autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(3)|lung(8)|skin(3)|urinary_tract(1)	23						CCGCACCGCCAGCTACATGAA	0.597000													9	20					0	0	1	0	0
SGCD	6444	broad.mit.edu	37	5	156184629	156184629	+	Missense_Mutation	SNP	C	C	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr5:156184629C>A	ENST00000435422.3	+	7	1097	c.610C>A	c.(610-612)Cca>Aca	p.P204T	SGCD_ENST00000447401.1_Missense_Mutation_p.P205T|SGCD_ENST00000517913.1_Missense_Mutation_p.P205T|SGCD_ENST00000337851.4_Missense_Mutation_p.P205T	NM_001128209.1	NP_001121681.1	Q92629	SGCD_HUMAN	sarcoglycan, delta (35kDa dystrophin-associated glycoprotein)	204					cytoskeleton organization|muscle organ development	cytoplasm|cytoskeleton|integral to membrane|sarcoglycan complex|sarcolemma		p.P205T(1)		breast(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(16)|prostate(1)	24	Renal(175;0.00488)	Medulloblastoma(196;0.0378)|all_neural(177;0.106)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			GATGGAGGCCCCAAAAGGAGT	0.458000													5	11					5.9392e-07	7.09824e-07	1	1	0
AKAP8L	26993	broad.mit.edu	37	19	15512273	15512273	+	Silent	SNP	G	G	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr19:15512273G>A	ENST00000397410.4	-	5	568	c.504C>T	c.(502-504)ttC>ttT	p.F168F	AKAP8L_ENST00000595465.1_Silent_p.F107F|AKAP8L_ENST00000595136.1_Intron	NM_014371.2	NP_055186.2	Q9ULX6	AKP8L_HUMAN	A kinase (PRKA) anchor protein 8-like	168						cytoplasm|nuclear matrix	DEAD/H-box RNA helicase binding|DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(4)|kidney(2)|lung(1)|ovary(1)|prostate(1)|urinary_tract(1)	11						CACGCATGCGGAACTGGTCGC	0.647000													14	81					0	0	1	0	0
P4HA2	8974	broad.mit.edu	37	5	131539795	131539795	+	Silent	SNP	G	G	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr5:131539795G>T	ENST00000401867.1	-	10	1699	c.1131C>A	c.(1129-1131)gcC>gcA	p.A377A	P4HA2_ENST00000379100.2_Silent_p.A377A|P4HA2_ENST00000360568.3_Silent_p.A377A|P4HA2_ENST00000379104.2_Silent_p.A377A|P4HA2_ENST00000166534.4_Silent_p.A377A|P4HA2_ENST00000379086.1_Silent_p.A377A			O15460	P4HA2_HUMAN	prolyl 4-hydroxylase, alpha polypeptide II	377						endoplasmic reticulum lumen	electron carrier activity|iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-proline 4-dioxygenase activity|protein binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(8)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)	24		all_cancers(142;0.103)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)		L-Proline(DB00172)|Succinic acid(DB00139)	CCCGGTAGCTGGCGACAGTGA	0.522000													6	97					8.12818e-05	8.98474e-05	1	1	0
MRPL21	219927	broad.mit.edu	37	11	68668016	68668016	+	Splice_Site	SNP	C	C	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr11:68668016C>A	ENST00000362034.2	-	2	155	c.146_splice	c.e2+1	p.G49_splice	MRPL21_ENST00000450904.2_5'UTR|MRPL21_ENST00000567045.1_5'UTR	NM_181514.1|NM_181515.1	NP_852615.1|NP_852616.1	Q7Z2W9	RM21_HUMAN	mitochondrial ribosomal protein L21	49					translation	mitochondrion|ribosome	RNA binding|structural constituent of ribosome			large_intestine(1)|lung(6)|prostate(1)	8			STAD - Stomach adenocarcinoma(18;0.0208)|LUAD - Lung adenocarcinoma(13;0.0713)			TTGATATTACCCTGGTAGATA	0.378000													23	158					2.39556e-15	3.39372e-15	1	1	0
KRT1	3848	broad.mit.edu	37	12	53074188	53074188	+	Translation_Start_Site	SNP	C	C	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr12:53074188C>A	ENST00000252244.3	-	0	3					NM_006121.3	NP_006112.3	P04264	K2C1_HUMAN	keratin 1						complement activation, lectin pathway|epidermis development|fibrinolysis|regulation of angiogenesis|response to oxidative stress	plasma membrane	protein binding|receptor activity|structural constituent of cytoskeleton|sugar binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(7)|lung(11)|ovary(1)|prostate(7)|skin(3)	39						CTAAACACTCCTCTACCCCAA	0.488000													6	43					0.217242	0.218127	1	1	0
CD109	135228	broad.mit.edu	37	6	74524753	74524753	+	Missense_Mutation	SNP	G	G	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr6:74524753G>T	ENST00000437994.2	+	30	4198	c.3767G>T	c.(3766-3768)aGa>aTa	p.R1256I	CD109_ENST00000422508.2_Missense_Mutation_p.R1196I|CD109_ENST00000287097.5_Missense_Mutation_p.R1273I	NM_001159587.1|NM_133493.3	NP_001153059.1|NP_598000.2	Q6YHK3	CD109_HUMAN	CD109 molecule	1273						anchored to membrane|extracellular space|plasma membrane	serine-type endopeptidase inhibitor activity			NS(2)|biliary_tract(1)|breast(1)|endometrium(4)|kidney(2)|large_intestine(18)|liver(2)|lung(26)|ovary(2)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	63						AGAAGACGAAGATCTATCCAA	0.323000													9	19					1.12685e-05	1.29496e-05	1	1	0
WBP2	23558	broad.mit.edu	37	17	73843060	73843060	+	Missense_Mutation	SNP	C	C	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr17:73843060C>T	ENST00000591399.1	-	8	1085	c.661G>A	c.(661-663)Gcc>Acc	p.A221T	WBP2_ENST00000590221.1_Missense_Mutation_p.A217T|WBP2_ENST00000585462.1_Missense_Mutation_p.A199T|WBP2_ENST00000254806.3_Missense_Mutation_p.A221T|WBP2_ENST00000344296.4_Missense_Mutation_p.A199T|WBP2_ENST00000433525.2_Missense_Mutation_p.A176T			Q969T9	WBP2_HUMAN	WW domain binding protein 2	221	Pro-rich.						protein binding			NS(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(2)	7			all cancers(21;2.61e-06)|Epithelial(20;2.92e-06)|BRCA - Breast invasive adenocarcinoma(9;0.00092)|LUSC - Lung squamous cell carcinoma(166;0.154)			GCGGCCTTGGCTTCGGCTGTG	0.632000													8	32					0	0	1	0	0
CMTM4	146223	broad.mit.edu	37	16	66670368	66670368	+	Missense_Mutation	SNP	C	C	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr16:66670368C>A	ENST00000330687.4	-	2	484	c.303G>T	c.(301-303)ttG>ttT	p.L101F	CMTM4_ENST00000563952.1_Missense_Mutation_p.L72F|CMTM4_ENST00000394106.2_Missense_Mutation_p.L101F	NM_178818.2|NM_181521.2	NP_848933.1|NP_852662.1	Q8IZR5	CKLF4_HUMAN	CKLF-like MARVEL transmembrane domain containing 4	101	MARVEL.				chemotaxis	extracellular space|integral to membrane	cytokine activity			cervix(1)|kidney(1)|large_intestine(3)|lung(1)|ovary(1)|pancreas(1)|stomach(1)	9		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0811)|Epithelial(162;0.214)		ACATAATCAGCAAGACGCCAG	0.502000													15	50					6.31663e-08	7.82436e-08	1	1	0
C3P1	388503	broad.mit.edu	37	19	10169736	10169736	+	RNA	SNP	G	G	C			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr19:10169736G>C	ENST00000495140.1	+	0	2136																				endometrium(4)|large_intestine(2)|lung(6)|urinary_tract(1)	13						agtgtttcctgagcatccact	0.517000													17	30					0	0	1	0	0
OR2G2	81470	broad.mit.edu	37	1	247752051	247752051	+	Missense_Mutation	SNP	C	C	G			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr1:247752051C>G	ENST00000320065.1	+	1	390	c.390C>G	c.(388-390)tgC>tgG	p.C130W	RP11-978I15.10_ENST00000435333.1_RNA|RP11-978I15.10_ENST00000446347.1_RNA	NM_001001915.1	NP_001001915.1	Q8NGZ5	OR2G2_HUMAN	olfactory receptor, family 2, subfamily G, member 2	130					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(4)|kidney(4)|large_intestine(3)|lung(30)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	45	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.017)			TGGCTGTCTGCCGTCCTCTCC	0.542000													30	247					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179443544	179443544	+	Missense_Mutation	SNP	C	C	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr2:179443544C>T	ENST00000589042.1	-	320	68437	c.68213G>A	c.(68212-68214)aGa>aAa	p.R22738K	RP11-171I2.2_ENST00000603521.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.R13865K|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000586707.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.R13798K|TTN-AS1_ENST00000419746.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.R21097K|TTN-AS1_ENST00000586831.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000590932.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.R20170K|TTN-AS1_ENST00000456053.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN-AS1_ENST00000592600.1_RNA|TTN-AS1_ENST00000592750.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.R13673K|TTN-AS1_ENST00000438095.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000592689.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	21097	Fibronectin type-III 65.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AAATGGATGTCTCGCAACAAT	0.398000													11	81					0	0	1	0	0
ANGEL2	90806	broad.mit.edu	37	1	213170529	213170529	+	Missense_Mutation	SNP	G	G	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr1:213170529G>A	ENST00000366962.3	-	8	1605	c.1451C>T	c.(1450-1452)tCt>tTt	p.S484F	ANGEL2_ENST00000535388.1_3'UTR|ANGEL2_ENST00000360506.2_Missense_Mutation_p.S315F|ANGEL2_ENST00000540642.1_Missense_Mutation_p.S358F|ANGEL2_ENST00000544555.1_Missense_Mutation_p.S315F|ANGEL2_ENST00000473303.1_5'UTR	NM_144567.3	NP_653168.2	Q5VTE6	ANGE2_HUMAN	angel homolog 2 (Drosophila)	484										central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(8)|lung(8)|skin(1)	24				OV - Ovarian serous cystadenocarcinoma(81;0.00446)|all cancers(67;0.0169)|Epithelial(68;0.0921)|GBM - Glioblastoma multiforme(131;0.185)		CTTTTCTGCAGAGTAGAAAAT	0.403000													17	72					0	0	1	0	0
XIRP2	129446	broad.mit.edu	37	2	168100533	168100533	+	Silent	SNP	T	T	C			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr2:168100533T>C	ENST00000409195.1	+	9	2720	c.2631T>C	c.(2629-2631)caT>caC	p.H877H	XIRP2_ENST00000409043.1_Intron|XIRP2_ENST00000409605.1_Intron|XIRP2_ENST00000295237.9_Silent_p.H877H|XIRP2_ENST00000420519.1_Intron|XIRP2_ENST00000409273.1_Silent_p.H655H|XIRP2_ENST00000409728.1_Intron|XIRP2_ENST00000409756.2_Intron	NM_152381.5	NP_689594.4	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2	702					actin cytoskeleton organization	cell junction	actin binding			NS(3)|biliary_tract(2)|breast(5)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(51)|lung(160)|ovary(7)|pancreas(3)|prostate(11)|skin(14)|stomach(5)|upper_aerodigestive_tract(8)|urinary_tract(7)	315						CTACTAAGCATCTATTTGAAA	0.378000													19	96					0	0	1	0	0
NARS	4677	broad.mit.edu	37	18	55280856	55280856	+	Missense_Mutation	SNP	C	C	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr18:55280856C>A	ENST00000256854.5	-	5	854	c.399G>T	c.(397-399)tgG>tgT	p.W133C	NARS_ENST00000423481.2_Intron	NM_004539.3	NP_004530.1	O43776	SYNC_HUMAN	asparaginyl-tRNA synthetase	133					asparaginyl-tRNA aminoacylation	cytosol|soluble fraction	asparagine-tRNA ligase activity|ATP binding|nucleic acid binding|protein binding			breast(1)|endometrium(5)|large_intestine(5)|lung(8)|skin(1)	20		Colorectal(73;0.227)			L-Asparagine(DB00174)	GCCTGTGGACCCAGCCAAACA	0.368000													11	46					4.36969e-10	5.70664e-10	1	1	0
ZNF226	7769	broad.mit.edu	37	19	44681351	44681351	+	Missense_Mutation	SNP	G	G	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr19:44681351G>A	ENST00000590089.1	+	7	2303	c.1936G>A	c.(1936-1938)Gaa>Aaa	p.E646K	ZNF226_ENST00000454662.2_Missense_Mutation_p.E646K|ZNF226_ENST00000337433.5_Missense_Mutation_p.E646K|ZNF226_ENST00000588883.1_3'UTR			Q9NYT6	ZN226_HUMAN	zinc finger protein 226	646					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding						Prostate(69;0.0352)|all_neural(266;0.202)				ATTCAAATGTGAAGAATGTGG	0.463000													31	107					0	0	1	0	0
CENPE	1062	broad.mit.edu	37	4	104030188	104030188	+	Missense_Mutation	SNP	C	C	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr4:104030188C>T	ENST00000265148.3	-	48	7872	c.7783G>A	c.(7783-7785)Gag>Aag	p.E2595K	CENPE_ENST00000380026.3_Missense_Mutation_p.E2474K	NM_001813.2	NP_001804.2	Q02224	CENPE_HUMAN	centromere protein E, 312kDa	2595	Globular autoinhibitory domain (By similarity).				blood coagulation|cell division|kinetochore assembly|microtubule-based movement|mitotic chromosome movement towards spindle pole|mitotic metaphase|mitotic metaphase plate congression|mitotic prometaphase|multicellular organismal development|positive regulation of protein kinase activity	condensed chromosome kinetochore|cytosol|microtubule|nucleus|spindle	ATP binding|kinetochore binding|microtubule motor activity			NS(3)|breast(6)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(20)|lung(34)|ovary(5)|pancreas(1)|prostate(2)|skin(3)|stomach(5)|urinary_tract(3)	101				OV - Ovarian serous cystadenocarcinoma(123;2.95e-08)		TTGTGAGCCTCTCTTTTAAGG	0.388000													10	43					0	0	1	0	0
MMS22L	253714	broad.mit.edu	37	6	97634411	97634411	+	Missense_Mutation	SNP	T	T	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr6:97634411T>A	ENST00000275053.4	-	15	2460	c.2195A>T	c.(2194-2196)cAg>cTg	p.Q732L	MMS22L_ENST00000369251.2_Missense_Mutation_p.Q692L	NM_198468.2	NP_940870.2	Q6ZRQ5	MMS22_HUMAN	MMS22-like, DNA repair protein	732					double-strand break repair via homologous recombination|replication fork processing	nuclear replication fork	protein binding			breast(1)|endometrium(9)|kidney(2)|large_intestine(12)|lung(20)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)	50						AGGCACTACCTGTGACATTCT	0.418000													13	59					0	0	1	0	0
AUH	549	broad.mit.edu	37	9	94060303	94060303	+	Silent	SNP	A	A	G			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr9:94060303A>G	ENST00000375731.4	-	5	584	c.561T>C	c.(559-561)ggT>ggC	p.G187G	AUH_ENST00000422391.2_Silent_p.G187G|AUH_ENST00000478465.1_5'UTR|AUH_ENST00000303617.5_Silent_p.G158G	NM_001698.2	NP_001689.1	Q13825	AUHM_HUMAN	AU RNA binding protein/enoyl-CoA hydratase	187					branched chain family amino acid catabolic process|mRNA catabolic process	mitochondrial matrix	enoyl-CoA hydratase activity|methylglutaconyl-CoA hydratase activity|mRNA 3'-UTR binding			endometrium(3)|kidney(1)|large_intestine(2)|lung(4)|prostate(1)	11						CCAGTTCAAGACCACCACCTA	0.343000													14	32					0	0	1	0	0
CCDC178	374864	broad.mit.edu	37	18	30825289	30825289	+	Missense_Mutation	SNP	T	T	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr18:30825289T>A	ENST00000383096.3	-	15	1695	c.1513A>T	c.(1513-1515)Att>Ttt	p.I505F	CCDC178_ENST00000579947.1_Missense_Mutation_p.I505F|CCDC178_ENST00000403303.1_Missense_Mutation_p.I505F|CCDC178_ENST00000583930.1_Missense_Mutation_p.I505F|CCDC178_ENST00000406524.2_Missense_Mutation_p.I505F|CCDC178_ENST00000402325.1_Missense_Mutation_p.I505F|CCDC178_ENST00000300227.8_Missense_Mutation_p.I505F|CCDC178_ENST00000579916.1_Intron					coiled-coil domain containing 178																		AGAGTACCAATGCGATAAGCC	0.323000													8	11					0	0	1	0	0
TG	7038	broad.mit.edu	37	8	134125759	134125759	+	Missense_Mutation	SNP	G	G	A	rs144050001	byFrequency	TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr8:134125759G>A	ENST00000220616.4	+	44	7706	c.7666G>A	c.(7666-7668)Gtc>Atc	p.V2556I	TG_ENST00000377869.1_Missense_Mutation_p.V2499I|TG_ENST00000542445.1_Missense_Mutation_p.V926I|TG_ENST00000519543.1_Missense_Mutation_p.V689I	NM_003235.4	NP_003226.4	P01266	THYG_HUMAN	thyroglobulin	2556					hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			NS(1)|breast(11)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(34)|liver(2)|lung(59)|ovary(9)|pancreas(2)|prostate(6)|skin(7)|stomach(4)|upper_aerodigestive_tract(4)|urinary_tract(8)	168	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		AGATGCCCGCGTCGAGGCTGC	0.547000													20	44					0	0	1	0	0
INTS2	57508	broad.mit.edu	37	17	59952278	59952278	+	Missense_Mutation	SNP	G	G	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr17:59952278G>A	ENST00000444766.3	-	19	2677	c.2602C>T	c.(2602-2604)Cac>Tac	p.H868Y	INTS2_ENST00000251334.6_Missense_Mutation_p.H860Y	NM_020748.2	NP_065799.1	Q9H0H0	INT2_HUMAN	integrator complex subunit 2	868					snRNA processing	integral to membrane|integrator complex|nuclear membrane	protein binding			NS(1)|breast(2)|cervix(2)|endometrium(3)|kidney(2)|large_intestine(6)|lung(15)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	38						ATGTACCTGTGAACCCTCTGA	0.328000													3	12					0	0	1	0	0
CYP7B1	9420	broad.mit.edu	37	8	65528405	65528405	+	Silent	SNP	G	G	C			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr8:65528405G>C	ENST00000310193.3	-	3	866	c.693C>G	c.(691-693)ccC>ccG	p.P231P		NM_004820.3	NP_004811.1	O75881	CP7B1_HUMAN	cytochrome P450, family 7, subfamily B, polypeptide 1	231					bile acid biosynthetic process|cell death|cholesterol metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	25-hydroxycholesterol 7alpha-hydroxylase activity|electron carrier activity|heme binding|oxysterol 7-alpha-hydroxylase activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(11)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	28		all_cancers(86;0.217)|Lung NSC(129;0.0521)|all_lung(136;0.0906)|all_epithelial(80;0.215)				GAAGCTCAATGGGTATGTTGG	0.308000													15	67					0	0	1	0	0
APBA2	321	broad.mit.edu	37	15	29386495	29386495	+	Silent	SNP	T	T	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr15:29386495T>A	ENST00000558402.1	+	9	1829	c.1230T>A	c.(1228-1230)gcT>gcA	p.A410A	APBA2_ENST00000561069.1_Silent_p.A410A|APBA2_ENST00000558259.1_Silent_p.A410A|APBA2_ENST00000558330.1_Intron|APBA2_ENST00000411764.1_Intron			Q99767	APBA2_HUMAN	amyloid beta (A4) precursor protein-binding, family A, member 2	410	PID.				nervous system development|protein transport		protein binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(7)|liver(2)|lung(33)|stomach(1)|urinary_tract(1)	59		all_lung(180;1.73e-12)|Breast(32;2.89e-05)|Colorectal(260;0.234)		all cancers(64;7.44e-11)|Epithelial(43;5.74e-10)|GBM - Glioblastoma multiforme(186;0.026)|BRCA - Breast invasive adenocarcinoma(123;0.0286)|Lung(196;0.24)		TGCAAAAGGCTGCTAAGATCA	0.517000													21	93					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179586807	179586807	+	Missense_Mutation	SNP	G	G	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr2:179586807G>A	ENST00000589042.1	-	78	22807	c.22583C>T	c.(22582-22584)gCt>gTt	p.A7528V	TTN_ENST00000342175.6_Intron|TTN_ENST00000359218.5_Intron|TTN_ENST00000591111.1_Missense_Mutation_p.A7211V|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.A6284V|TTN_ENST00000460472.2_Intron	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	7211	Ig-like 57.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ACTTTCTCCAGCAATAACATC	0.398000													34	144					0	0	1	0	0
USP32	84669	broad.mit.edu	37	17	58299796	58299796	+	Nonsense_Mutation	SNP	C	C	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr17:58299796C>A	ENST00000300896.4	-	15	1917	c.1723G>T	c.(1723-1725)Gga>Tga	p.G575*	USP32_ENST00000592339.1_Nonsense_Mutation_p.G245*	NM_032582.3	NP_115971.2	Q8NFA0	UBP32_HUMAN	ubiquitin specific peptidase 32	575	DUSP.				protein deubiquitination|ubiquitin-dependent protein catabolic process	Golgi apparatus|membrane	calcium ion binding|cysteine-type peptidase activity|ubiquitin thiolesterase activity			NS(3)|breast(5)|endometrium(5)|kidney(4)|large_intestine(12)|liver(1)|lung(24)|pancreas(1)|prostate(3)|skin(3)|urinary_tract(1)	62	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		Epithelial(12;2.02e-11)|all cancers(12;5.23e-10)|Colorectal(3;0.198)			AGGTTTGCTCCATACCAGTGA	0.428000													91	244					1.3521e-30	2.07014e-30	1	1	0
CAD	790	broad.mit.edu	37	2	27454872	27454872	+	Missense_Mutation	SNP	C	C	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr2:27454872C>T	ENST00000264705.4	+	17	2587	c.2425C>T	c.(2425-2427)Cgg>Tgg	p.R809W	CAD_ENST00000403525.1_Missense_Mutation_p.R746W|CAD_ENST00000464159.1_3'UTR	NM_004341.3	NP_004332.2	P27708	PYR1_HUMAN	carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase	809	CPSase (Carbamoyl-phosphate synthase).|CPSase A.				'de novo' pyrimidine base biosynthetic process|drug metabolic process|glutamine metabolic process|peptidyl-threonine phosphorylation|protein autophosphorylation|pyrimidine nucleoside biosynthetic process|pyrimidine nucleotide biosynthetic process	cytosol|neuronal cell body|nuclear matrix|terminal button	aspartate binding|aspartate carbamoyltransferase activity|ATP binding|carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity|dihydroorotase activity|enzyme binding|identical protein binding|metal ion binding|protein kinase activity			NS(1)|breast(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(19)|lung(40)|ovary(6)|pancreas(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	92	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				L-Aspartic Acid(DB00128)|L-Glutamine(DB00130)	AACAGATAAGCGGATTTTTGT	0.532000													12	82					0	0	1	0	0
SLC26A7	115111	broad.mit.edu	37	8	92301364	92301364	+	Splice_Site	SNP	G	G	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr8:92301364G>T	ENST00000276609.3	+	3	433	c.193_splice	c.e3-1	p.G65_splice	SLC26A7_ENST00000523719.1_Splice_Site_p.G65_splice|SLC26A7_ENST00000309536.2_Splice_Site_p.G65_splice	NM_052832.2	NP_439897.1	Q8TE54	S26A7_HUMAN	solute carrier family 26 (anion exchanger), member 7	65						basolateral plasma membrane|integral to membrane|recycling endosome membrane	anion:anion antiporter activity|bicarbonate transmembrane transporter activity|chloride channel activity|oxalate transmembrane transporter activity|sulfate transmembrane transporter activity			breast(1)|cervix(1)|endometrium(4)|large_intestine(10)|lung(26)|ovary(3)|skin(4)|upper_aerodigestive_tract(1)	50			BRCA - Breast invasive adenocarcinoma(11;0.00802)			TTCTTCACAGGATTGGCCTTT	0.383000													11	75					0.000673444	0.0007257	1	1	0
IKZF1	10320	broad.mit.edu	37	7	50467627	50467627	+	Missense_Mutation	SNP	C	C	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr7:50467627C>A	ENST00000331340.3	+	8	1017	c.862C>A	c.(862-864)Ctg>Atg	p.L288M	IKZF1_ENST00000346667.4_Missense_Mutation_p.L58M|IKZF1_ENST00000439701.1_Missense_Mutation_p.L246M|IKZF1_ENST00000438033.1_Missense_Mutation_p.L201M|IKZF1_ENST00000343574.5_Missense_Mutation_p.L201M|IKZF1_ENST00000440768.2_3'UTR|IKZF1_ENST00000357364.4_Missense_Mutation_p.L201M|IKZF1_ENST00000359197.5_Missense_Mutation_p.L246M|IKZF1_ENST00000349824.4_Missense_Mutation_p.L145M	NM_001220769.1|NM_001220772.1|NM_001220773.1|NM_001220775.1|NM_006060.4	NP_001207698.1|NP_001207701.1|NP_001207702.1|NP_001207704.1|NP_006051.1	Q13422	IKZF1_HUMAN	IKAROS family zinc finger 1 (Ikaros)	288					cell cycle|chromatin modification|mesoderm development	cytoplasm|nucleus	zinc ion binding	p.?(28)		haematopoietic_and_lymphoid_tissue(275)|lung(1)	276	Glioma(55;0.08)|all_neural(89;0.245)	Acute lymphoblastic leukemia(4;7.29e-10)|all_hematologic(4;4.8e-07)				GGACAAGGGCCTGTCCGACAC	0.592000			"""D,T"""	BCL6	"""ALL, DLBCL"""								3	23					0.150653	0.151731	1	1	0
IL9R	3581	broad.mit.edu	37	X	155239751	155239751	+	Missense_Mutation	SNP	C	C	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chrX:155239751C>A	ENST00000424344.3	+	10	1547	c.1180C>A	c.(1180-1182)Ccc>Acc	p.P394T	IL9R_ENST00000369423.2_3'UTR|IL9R_ENST00000540897.1_3'UTR|IL9R_ENST00000244174.5_Missense_Mutation_p.P415T			Q01113	IL9R_HUMAN	interleukin 9 receptor	415					cell proliferation	extracellular space|integral to plasma membrane	interleukin-9 receptor activity			NS(1)|central_nervous_system(1)|cervix(2)|endometrium(2)|kidney(3)|large_intestine(1)|lung(12)|upper_aerodigestive_tract(1)	23	all_cancers(53;1.86e-17)|all_epithelial(53;2.71e-11)|all_lung(58;1.84e-07)|Lung NSC(58;5.62e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)					GGACTGGGCCCCCACGTCCCT	0.637000													3	18					0.00116845	0.00124685	1	1	0
ADAT1	23536	broad.mit.edu	37	16	75634134	75634134	+	Missense_Mutation	SNP	C	C	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr16:75634134C>A	ENST00000307921.3	-	11	1634	c.1489G>T	c.(1489-1491)Gat>Tat	p.D497Y	ADAT1_ENST00000568478.1_5'UTR|RP11-77K12.8_ENST00000564489.1_RNA	NM_012091.3	NP_036223.2	Q9BUB4	ADAT1_HUMAN	adenosine deaminase, tRNA-specific 1	497	A to I editase.				tRNA processing		metal ion binding|RNA binding|tRNA-specific adenosine deaminase activity			breast(1)|endometrium(4)|large_intestine(3)|lung(7)|ovary(1)|prostate(1)|skin(1)|stomach(1)	19						TGGTGATAATCCGGTGGGTTT	0.517000													27	110					9.39395e-14	1.31382e-13	1	1	0
USP20	10868	broad.mit.edu	37	9	132620769	132620769	+	Silent	SNP	G	G	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr9:132620769G>T	ENST00000315480.4	+	6	380	c.222G>T	c.(220-222)gtG>gtT	p.V74V	USP20_ENST00000358355.1_Silent_p.V74V|USP20_ENST00000372429.3_Silent_p.V74V			Q9Y2K6	UBP20_HUMAN	ubiquitin specific peptidase 20	74					endocytosis|protein K48-linked deubiquitination|protein K63-linked deubiquitination|regulation of G-protein coupled receptor protein signaling pathway|ubiquitin-dependent protein catabolic process	perinuclear region of cytoplasm	cysteine-type endopeptidase activity|G-protein-coupled receptor binding|ubiquitin thiolesterase activity|zinc ion binding			breast(1)|endometrium(2)|large_intestine(3)|lung(4)|urinary_tract(1)	11		Ovarian(14;0.00556)				ACTTGACCGTGAACCTGACCA	0.552000													49	87					1.62263e-30	2.48048e-30	1	1	0
SOAT1	6646	broad.mit.edu	37	1	179306970	179306970	+	Splice_Site	SNP	A	A	C			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr1:179306970A>C	ENST00000367619.3	+	5	472		c.e5-1		SOAT1_ENST00000539888.1_Splice_Site|SOAT1_ENST00000540564.1_Splice_Site|SOAT1_ENST00000535686.1_Splice_Site	NM_003101.5	NP_003092.4	P35610	SOAT1_HUMAN	sterol O-acyltransferase 1						cholesterol efflux|cholesterol esterification|cholesterol homeostasis|cholesterol metabolic process|cholesterol storage|macrophage derived foam cell differentiation|positive regulation of amyloid precursor protein biosynthetic process|very-low-density lipoprotein particle assembly	endoplasmic reticulum membrane|integral to membrane|microsome	cholesterol binding|cholesterol O-acyltransferase activity|fatty-acyl-CoA binding			central_nervous_system(1)|endometrium(3)|large_intestine(1)|lung(10)|prostate(1)|skin(3)|stomach(1)	20					Ezetimibe(DB00973)|Hesperetin(DB01094)	TCCTCTTCTCAGGGATTTGAG	0.308000													7	7					0	0	1	0	0
TMEM174	134288	broad.mit.edu	37	5	72469361	72469361	+	Silent	SNP	C	C	G			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr5:72469361C>G	ENST00000296776.5	+	1	340	c.291C>G	c.(289-291)tcC>tcG	p.S97S	TMEM174_ENST00000511737.1_3'UTR	NM_153217.2	NP_694949.1	Q8WUU8	TM174_HUMAN	transmembrane protein 174	97						integral to membrane				endometrium(1)|large_intestine(2)|lung(2)|ovary(1)|skin(1)	7		Lung NSC(167;0.0378)|Ovarian(174;0.0908)|Prostate(461;0.165)		OV - Ovarian serous cystadenocarcinoma(47;1.46e-54)		AAATGCTCTCCTGCCAGTTGT	0.522000													12	79					0	0	1	0	0
ABCB5	340273	broad.mit.edu	37	7	20766705	20766705	+	Missense_Mutation	SNP	T	T	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr7:20766705T>A	ENST00000404938.2	+	22	3320	c.2668T>A	c.(2668-2670)Tta>Ata	p.L890I	ABCB5_ENST00000258738.6_Missense_Mutation_p.L445I	NM_001163941.1	NP_001157413.1	Q2M3G0	ABCB5_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 5	445					regulation of membrane potential	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus	ATP binding|ATPase activity, coupled to transmembrane movement of substances|efflux transmembrane transporter activity			breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(11)|liver(1)|lung(37)|ovary(1)|pancreas(1)|prostate(1)|skin(10)|upper_aerodigestive_tract(1)	77						TATAGTGTCATTAACAAGGGA	0.313000													11	38					0	0	1	0	0
TSSC4	10078	broad.mit.edu	37	11	2424510	2424510	+	Missense_Mutation	SNP	C	C	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr11:2424510C>A	ENST00000333256.6	+	3	1090	c.647C>A	c.(646-648)aCc>aAc	p.T216N	TSSC4_ENST00000380996.5_Missense_Mutation_p.T152N|TSSC4_ENST00000451491.2_Missense_Mutation_p.T216N|TSSC4_ENST00000467308.1_Intron|TSSC4_ENST00000380992.1_Intron			Q9Y5U2	TSSC4_HUMAN	tumor suppressing subtransferable candidate 4	216										endometrium(3)|large_intestine(1)|lung(4)	8		all_epithelial(84;0.000161)|Breast(177;0.000962)|Medulloblastoma(188;0.00106)|Ovarian(85;0.0014)|all_neural(188;0.0137)|Lung NSC(207;0.209)		BRCA - Breast invasive adenocarcinoma(625;0.00145)|LUSC - Lung squamous cell carcinoma(625;0.19)		GTCATCTTCACCAAACCAGTC	0.652000													6	44					3.59834e-05	4.04556e-05	1	1	0
CPS1	1373	broad.mit.edu	37	2	211481179	211481179	+	Missense_Mutation	SNP	T	T	G			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr2:211481179T>G	ENST00000233072.5	+	21	2797	c.2601T>G	c.(2599-2601)atT>atG	p.I867M	CPS1_ENST00000430249.2_Missense_Mutation_p.I873M|CPS1_ENST00000451903.2_Missense_Mutation_p.I416M	NM_001875.4	NP_001866.2	P31327	CPSM_HUMAN	carbamoyl-phosphate synthase 1, mitochondrial	867					carbamoyl phosphate biosynthetic process|citrulline biosynthetic process|glutamine metabolic process|glycogen catabolic process|nitric oxide metabolic process|positive regulation of vasodilation|response to lipopolysaccharide|triglyceride catabolic process|urea cycle	mitochondrial nucleoid	ATP binding|carbamoyl-phosphate synthase (ammonia) activity			breast(1)|central_nervous_system(4)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(17)|lung(85)|ovary(8)|pancreas(1)|prostate(6)|skin(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	142				Epithelial(149;0.00697)|Lung(261;0.0521)|LUSC - Lung squamous cell carcinoma(261;0.0544)|all cancers(144;0.0843)		TTGATGAGATTGAGAAGCTCA	0.373000													14	82					0	0	1	0	0
C8A	731	broad.mit.edu	37	1	57372382	57372382	+	Missense_Mutation	SNP	T	T	C			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr1:57372382T>C	ENST00000361249.3	+	8	1235	c.1139T>C	c.(1138-1140)tTg>tCg	p.L380S		NM_000562.2	NP_000553.1	P07357	CO8A_HUMAN	complement component 8, alpha polypeptide	380	MACPF.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis	extracellular space|membrane attack complex				NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(25)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	43						GGAGGCTCCTTGGGCATTCAA	0.388000													36	95					0	0	1	0	0
OGT	8473	broad.mit.edu	37	X	70782994	70782994	+	Missense_Mutation	SNP	C	C	G			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chrX:70782994C>G	ENST00000373719.3	+	17	2380	c.2163C>G	c.(2161-2163)atC>atG	p.I721M	OGT_ENST00000373701.3_Missense_Mutation_p.I711M	NM_181672.2|NM_181673.2	NP_858058.1|NP_858059.1	O15294	OGT1_HUMAN	O-linked N-acetylglucosamine (GlcNAc) transferase	721					cellular response to retinoic acid|positive regulation of granulocyte differentiation|positive regulation of histone H3-K4 methylation|positive regulation of proteolysis|protein O-linked glycosylation|signal transduction	cytosol|MLL5-L complex	enzyme activator activity|protein binding|protein N-acetylglucosaminyltransferase activity			breast(6)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(5)|liver(3)|lung(9)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	43	Renal(35;0.156)					AAGCAGTCATCGATTTTAAGT	0.333000													37	36					0	0	1	0	0
MYO1H	283446	broad.mit.edu	37	12	109838916	109838916	+	Missense_Mutation	SNP	C	C	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr12:109838916C>T	ENST00000310903.5	+	6	647	c.541C>T	c.(541-543)Cat>Tat	p.H181Y	MYO1H_ENST00000431443.2_Missense_Mutation_p.H181Y			B4DNW6	B4DNW6_HUMAN	myosin IH	0						myosin complex	motor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(17)|prostate(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	47						CGTAGGTGGGCATATCATCAG	0.483000													4	23					0	0	1	0	0
ZFP2	80108	broad.mit.edu	37	5	178359304	178359304	+	Missense_Mutation	SNP	G	G	T	rs144510991		TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr5:178359304G>T	ENST00000361362.2	+	5	1520	c.990G>T	c.(988-990)gaG>gaT	p.E330D	ZFP2_ENST00000503510.2_Missense_Mutation_p.E330D|ZFP2_ENST00000523286.1_Missense_Mutation_p.E330D|ZFP2_ENST00000520301.1_Missense_Mutation_p.E330D	NM_030613.2	NP_085116.2	Q6ZN57	ZFP2_HUMAN	ZFP2 zinc finger protein	330					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|endometrium(2)|kidney(1)|large_intestine(7)|liver(1)|lung(2)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|stomach(1)	20	all_cancers(89;0.000639)|all_epithelial(37;0.000109)|Renal(175;0.000159)|Lung NSC(126;0.00199)|all_lung(126;0.00351)	all_neural(177;0.00802)|Medulloblastoma(196;0.0145)|all_hematologic(541;0.248)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.00655)|GBM - Glioblastoma multiforme(465;0.0302)|OV - Ovarian serous cystadenocarcinoma(192;0.0615)|Epithelial(171;0.111)		AATGTAACGAGTGTGGAAAAG	0.363000													9	70					1.12685e-05	1.29496e-05	1	1	0
CTNNA2	1496	broad.mit.edu	37	2	80097056	80097056	+	Missense_Mutation	SNP	C	C	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr2:80097056C>A	ENST00000466387.1	+	9	1304	c.580C>A	c.(580-582)Caa>Aaa	p.Q194K	CTNNA2_ENST00000402739.4_Missense_Mutation_p.Q194K|CTNNA2_ENST00000496558.1_Missense_Mutation_p.Q194K|CTNNA2_ENST00000361291.4_Missense_Mutation_p.Q228K|CTNNA2_ENST00000541047.1_Missense_Mutation_p.Q194K|CTNNA2_ENST00000540488.1_Missense_Mutation_p.Q194K			P26232	CTNA2_HUMAN	catenin (cadherin-associated protein), alpha 2	194					axonogenesis|brain morphogenesis|cell-cell adhesion|dendrite morphogenesis|muscle cell differentiation|positive regulation of muscle cell differentiation|prepulse inhibition|radial glia guided migration of Purkinje cell|regulation of synapse structural plasticity	actin cytoskeleton|axon|cytosol	cadherin binding|structural constituent of cytoskeleton			breast(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(49)|pancreas(4)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	78						AGCAAGAAGACAACAGGTGGG	0.403000													15	79					1.3612e-06	1.61122e-06	1	1	0
CHD2	1106	broad.mit.edu	37	15	93524057	93524057	+	Missense_Mutation	SNP	T	T	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr15:93524057T>A	ENST00000394196.4	+	23	3957	c.2889T>A	c.(2887-2889)ttT>ttA	p.F963L	CHD2_ENST00000557381.1_Missense_Mutation_p.F963L	NM_001271.3	NP_001262.3	O14647	CHD2_HUMAN	chromodomain helicase DNA binding protein 2	963					regulation of transcription from RNA polymerase II promoter	nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(5)|kidney(2)|large_intestine(10)|lung(17)|ovary(1)|prostate(2)|skin(2)|stomach(1)|urinary_tract(2)	47	Lung NSC(78;0.00976)|all_lung(78;0.016)		BRCA - Breast invasive adenocarcinoma(143;0.0282)|OV - Ovarian serous cystadenocarcinoma(32;0.0814)			CAAATCCTTTTAATAAAGAAG	0.363000													7	36					0	0	1	0	0
MC4R	4160	broad.mit.edu	37	18	58039199	58039199	+	Silent	SNP	C	C	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr18:58039199C>T	ENST00000299766.3	-	1	802	c.384G>A	c.(382-384)gtG>gtA	p.V128V		NM_005912.2	NP_005903.2	P32245	MC4R_HUMAN	melanocortin 4 receptor	128					feeding behavior|G-protein signaling, coupled to cAMP nucleotide second messenger|positive regulation of bone resorption|positive regulation of cAMP biosynthetic process	integral to membrane|plasma membrane	melanocyte-stimulating hormone receptor activity|neuropeptide binding|ubiquitin protein ligase binding			endometrium(2)|kidney(1)|large_intestine(5)|liver(2)|lung(5)|ovary(1)|upper_aerodigestive_tract(1)	17		Colorectal(73;0.0946)				AGCTACAGATCACCGAGTCAA	0.398000													14	70					0	0	1	0	0
CLVS1	157807	broad.mit.edu	37	8	62212461	62212461	+	Silent	SNP	T	T	C			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr8:62212461T>C	ENST00000519846.1	+	3	547	c.75T>C	c.(73-75)caT>caC	p.H25H	CLVS1_ENST00000518592.1_Intron|CLVS1_ENST00000325897.4_Silent_p.H25H			Q8IUQ0	CLVS1_HUMAN	clavesin 1	25					lysosome organization	clathrin-coated vesicle|early endosome membrane|trans-Golgi network	phosphatidylinositol-3,5-bisphosphate binding|transporter activity			endometrium(3)|kidney(4)|large_intestine(4)|lung(21)|ovary(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	41						AGATGACCCATTTACAGGCTG	0.453000													11	52					0	0	1	0	0
CENPA	1058	broad.mit.edu	37	2	27015103	27015103	+	Missense_Mutation	SNP	C	C	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr2:27015103C>T	ENST00000335756.4	+	2	405	c.205C>T	c.(205-207)Cgc>Tgc	p.R69C	CENPA_ENST00000475662.1_3'UTR|CENPA_ENST00000233505.8_Missense_Mutation_p.R69C	NM_001809.3	NP_001800.1	P49450	CENPA_HUMAN	centromere protein A	69	H3-like.				CenH3-containing nucleosome assembly at centromere|establishment of mitotic spindle orientation|interspecies interaction between organisms|kinetochore assembly|mitotic prometaphase|protein localization to chromosome, centromeric region	condensed nuclear chromosome kinetochore|cytosol|nucleoplasm|nucleosome	chromatin binding|DNA binding|protein binding			endometrium(1)|large_intestine(3)|lung(3)|urinary_tract(1)	8	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GCCCTTCAGCCGCCTGGTAAG	0.512000													9	13					0	0	1	0	0
RYR3	6263	broad.mit.edu	37	15	34072467	34072467	+	Missense_Mutation	SNP	G	G	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr15:34072467G>A	ENST00000389232.4	+	65	9263	c.9193G>A	c.(9193-9195)Gca>Aca	p.A3065T	RYR3_ENST00000415757.3_Missense_Mutation_p.A3065T	NM_001036.3	NP_001027.3	Q15413	RYR3_HUMAN	ryanodine receptor 3	3065					cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(3)|breast(9)|central_nervous_system(8)|cervix(2)|endometrium(29)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(55)|lung(148)|ovary(7)|pancreas(1)|prostate(13)|skin(4)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(3)	311		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		CATACCAGTGGCATTCCTGGA	0.547000													4	31					0	0	1	0	0
THADA	63892	broad.mit.edu	37	2	43783686	43783686	+	Silent	SNP	C	C	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr2:43783686C>T	ENST00000405006.4	-	17	2823	c.2472G>A	c.(2470-2472)ggG>ggA	p.G824G	THADA_ENST00000330266.7_Silent_p.G534G|THADA_ENST00000404790.1_Silent_p.G824G|THADA_ENST00000402360.2_Silent_p.G824G|THADA_ENST00000415080.2_Silent_p.G534G|THADA_ENST00000405975.2_Silent_p.G824G	NM_001083953.1|NM_001271643.1	NP_001077422.1|NP_001258572.1	Q6YHU6	THADA_HUMAN	thyroid adenoma associated	824							binding			breast(1)|endometrium(9)|kidney(5)|large_intestine(9)|liver(1)|lung(28)|ovary(4)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(5)	66		Acute lymphoblastic leukemia(82;0.00361)|all_hematologic(82;0.00837)				CTTGCAGTTTCCCCGAATCCT	0.403000													23	70					0	0	1	0	0
FAM217B	63939	broad.mit.edu	37	20	58519707	58519707	+	Missense_Mutation	SNP	C	C	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr20:58519707C>T	ENST00000358293.3	+	5	1124	c.709C>T	c.(709-711)Cac>Tac	p.H237Y	FAM217B_ENST00000360816.3_Missense_Mutation_p.H237Y|FAM217B_ENST00000469084.1_3'UTR	NM_001190826.1	NP_001177755.1	Q9NTX9	CT177_HUMAN	family with sequence similarity 217, member B	237																	GCCACTACCTCACCAGGAAGG	0.537000													17	123					0	0	1	0	0
CRISP2	7180	broad.mit.edu	37	6	49676855	49676855	+	Missense_Mutation	SNP	C	C	G			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr6:49676855C>G	ENST00000339139.4	-	4	291	c.55G>C	c.(55-57)Gca>Cca	p.A19P		NM_001142407.2|NM_001142408.2|NM_001142417.2|NM_001142435.2|NM_001261822.1|NM_003296.3	NP_001135879.1|NP_001135880.1|NP_001135889.1|NP_001135907.1|NP_001248751.1|NP_003287.1	P16562	CRIS2_HUMAN	cysteine-rich secretory protein 2	19						extracellular space				kidney(1)|large_intestine(2)|lung(10)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	19	Lung NSC(77;0.0161)		KIRC - Kidney renal clear cell carcinoma(2;0.106)|Kidney(12;0.156)			TTTCCTTCTGCAGGTAAAGAT	0.408000													8	46					0	0	1	0	0
USH2A	7399	broad.mit.edu	37	1	216017705	216017705	+	Missense_Mutation	SNP	C	C	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr1:216017705C>A	ENST00000366943.2	-	46	9575	c.9189G>T	c.(9187-9189)aaG>aaT	p.K3063N	USH2A_ENST00000307340.3_Missense_Mutation_p.K3063N			O75445	USH2A_HUMAN	Usher syndrome 2A (autosomal recessive, mild)	3063	Fibronectin type-III 17.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			NS(7)|breast(20)|central_nervous_system(3)|cervix(2)|endometrium(32)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(71)|liver(2)|lung(282)|ovary(25)|pancreas(2)|prostate(12)|skin(22)|stomach(7)|upper_aerodigestive_tract(20)|urinary_tract(3)	527				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		TCATTCCAGTCTTGTAGAGCT	0.398000										HNSCC(13;0.011)			13	63					5.50884e-06	6.36778e-06	1	1	0
POTEE	445582	broad.mit.edu	37	2	132021521	132021521	+	Silent	SNP	C	C	G			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr2:132021521C>G	ENST00000356920.5	+	15	2587	c.2493C>G	c.(2491-2493)gcC>gcG	p.A831A	PLEKHB2_ENST00000303908.3_Intron|PLEKHB2_ENST00000404460.1_Intron|POTEE_ENST00000358087.5_3'UTR	NM_001083538.1	NP_001077007.1	Q6S8J3	POTEE_HUMAN	POTE ankyrin domain family, member E	831	Actin-like.						ATP binding										ACACCCCAGCCATGTACGTGG	0.622000													35	274					0	0	1	0	0
GADL1	339896	broad.mit.edu	37	3	30891522	30891522	+	Missense_Mutation	SNP	C	C	A	rs146157052		TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr3:30891522C>A	ENST00000454381.3	-	6	663	c.617G>T	c.(616-618)gGt>gTt	p.G206V	GADL1_ENST00000282538.5_Missense_Mutation_p.G206V			Q6ZQY3	GADL1_HUMAN	glutamate decarboxylase-like 1	206					carboxylic acid metabolic process		carboxy-lyase activity|pyridoxal phosphate binding			breast(2)|endometrium(3)|kidney(2)|lung(17)|upper_aerodigestive_tract(1)	25					Pyridoxal Phosphate(DB00114)	TCTTGGCGAACCAGACAGCCC	0.333000													5	30					0.014758	0.0152052	1	1	0
HDAC3	8841	broad.mit.edu	37	5	141008845	141008845	+	Missense_Mutation	SNP	T	T	G			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr5:141008845T>G	ENST00000305264.3	-	7	584	c.505A>C	c.(505-507)Att>Ctt	p.I169L		NM_003883.3	NP_003874.2	O15379	HDAC3_HUMAN	histone deacetylase 3	169	Histone deacetylase.				anti-apoptosis|cellular lipid metabolic process|negative regulation of cell cycle|negative regulation of JNK cascade|negative regulation of transcription from RNA polymerase II promoter|nerve growth factor receptor signaling pathway|spindle assembly|transcription, DNA-dependent	cytoplasm|histone deacetylase complex|spindle microtubule|transcriptional repressor complex	histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|transcription corepressor activity|transcription factor binding			endometrium(1)|large_intestine(2)|lung(3)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	13			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)		Vorinostat(DB02546)	TGGATGTCAATGTCAATGTAG	0.537000													7	49					0	0	1	0	0
SLC1A3	6507	broad.mit.edu	37	5	36677181	36677181	+	Missense_Mutation	SNP	G	G	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr5:36677181G>T	ENST00000265113.4	+	6	1231	c.755G>T	c.(754-756)tGc>tTc	p.C252F	SLC1A3_ENST00000381918.3_Missense_Mutation_p.C252F|CTD-2353F22.1_ENST00000510740.1_RNA	NM_004172.4	NP_004163.3	P43003	EAA1_HUMAN	solute carrier family 1 (glial high affinity glutamate transporter), member 3	252					D-aspartate import|L-glutamate import|neurotransmitter uptake	integral to membrane|membrane fraction	high-affinity glutamate transmembrane transporter activity|sodium:dicarboxylate symporter activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(8)|liver(1)|lung(23)|skin(1)	41	all_lung(31;0.000245)		Epithelial(62;0.0444)|Lung(74;0.111)|all cancers(62;0.128)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)		L-Glutamic Acid(DB00142)	TTCTCCATGTGCTTCGGTTTT	0.493000													41	65					2.54651e-27	3.86881e-27	1	1	0
CUX1	1523	broad.mit.edu	37	7	101459331	101459331	+	Silent	SNP	G	G	C			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr7:101459331G>C	ENST00000360264.3	+	1	41	c.21G>C	c.(19-21)tcG>tcC	p.S7S	CUX1_ENST00000425244.2_Silent_p.S7S|CUX1_ENST00000437600.4_Silent_p.S7S|CUX1_ENST00000292538.4_Silent_p.S7S|CUX1_ENST00000547394.2_Silent_p.S7S|CUX1_ENST00000393824.3_Silent_p.S7S	NM_001202543.1	NP_001189472.1	P39880	CUX1_HUMAN	cut-like homeobox 1	0					negative regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|central_nervous_system(1)|cervix(2)|endometrium(6)|kidney(3)|large_intestine(8)|lung(26)|ovary(7)|pancreas(1)|prostate(6)|skin(2)|stomach(1)|urinary_tract(5)	70						ATGTGGGATCGATGTTTCAAT	0.642000													10	74					0	0	1	0	0
LAMA1	284217	broad.mit.edu	37	18	6986209	6986209	+	Missense_Mutation	SNP	C	C	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr18:6986209C>A	ENST00000389658.3	-	37	5399	c.5306G>T	c.(5305-5307)aGg>aTg	p.R1769M		NM_005559.3	NP_005550.2	P25391	LAMA1_HUMAN	laminin, alpha 1	1769	Domain II and I.				axon guidance|cell adhesion|cell surface receptor linked signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	extracellular space|laminin-1 complex|laminin-3 complex	extracellular matrix structural constituent|receptor binding			NS(4)|breast(7)|central_nervous_system(3)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(49)|liver(1)|lung(71)|ovary(9)|pancreas(3)|prostate(5)|skin(11)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(3)	205		Colorectal(10;0.172)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	CTCAGCTTCCCTCACGAGCGC	0.498000													38	161					1.96642e-18	2.87243e-18	1	1	0
OR6K2	81448	broad.mit.edu	37	1	158669933	158669933	+	Silent	SNP	C	C	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr1:158669933C>A	ENST00000359610.2	-	1	553	c.510G>T	c.(508-510)tcG>tcT	p.S170S		NM_001005279.1	NP_001005279.1	Q8NGY2	OR6K2_HUMAN	olfactory receptor, family 6, subfamily K, member 2	170					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(7)|lung(22)|ovary(1)|pancreas(1)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	46	all_hematologic(112;0.0378)					CAAGGTGATTCGAACCACAAA	0.483000													16	112					6.31663e-08	7.82436e-08	1	1	0
GPR31	2853	broad.mit.edu	37	6	167571269	167571269	+	Silent	SNP	C	C	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr6:167571269C>A	ENST00000366834.1	-	1	548	c.51G>T	c.(49-51)gtG>gtT	p.V17V		NM_005299.2	NP_005290.2	O00270	GPR31_HUMAN	G protein-coupled receptor 31	17						integral to plasma membrane	G-protein coupled receptor activity			NS(1)|endometrium(4)|large_intestine(4)|lung(7)|prostate(1)	17		Breast(66;1.53e-05)|Ovarian(120;0.0606)		OV - Ovarian serous cystadenocarcinoma(33;4.81e-20)|BRCA - Breast invasive adenocarcinoma(81;4.45e-06)|GBM - Glioblastoma multiforme(31;0.00492)		GCAAGACACCCACAGCTGTGG	0.657000													5	19					1.23904e-05	1.41892e-05	1	1	0
FBN3	84467	broad.mit.edu	37	19	8190789	8190789	+	Silent	SNP	G	G	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr19:8190789G>T	ENST00000600128.1	-	22	3132	c.2718C>A	c.(2716-2718)ggC>ggA	p.G906G	FBN3_ENST00000270509.2_Silent_p.G906G|FBN3_ENST00000601739.1_Silent_p.G906G			Q75N90	FBN3_HUMAN	fibrillin 3	906	EGF-like 11; calcium-binding.					proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			NS(1)|breast(9)|central_nervous_system(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(15)|lung(53)|ovary(7)|pancreas(2)|prostate(3)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	132						CGCACAGCCGGCCTGAGGCGT	0.612000													14	60					6.72482e-11	8.94828e-11	1	1	0
SLC28A2	9153	broad.mit.edu	37	15	45560576	45560576	+	Splice_Site	SNP	G	G	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr15:45560576G>A	ENST00000347644.3	+	13	1433	c.1368_splice	c.e13+1	p.Q456_splice	CTD-2651B20.3_ENST00000561404.1_RNA|CTD-2651B20.3_ENST00000560344.1_RNA	NM_004212.3	NP_004203.2	O43868	S28A2_HUMAN	solute carrier family 28 (concentrative nucleoside transporter), member 2	456					nucleobase, nucleoside and nucleotide metabolic process	integral to plasma membrane|membrane fraction	nucleoside binding|nucleoside:sodium symporter activity|purine nucleoside transmembrane transporter activity	p.Q456H(1)		NS(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(12)|ovary(4)|skin(1)	26		all_cancers(109;8.53e-07)|all_epithelial(112;1.39e-05)|Lung NSC(122;8.3e-05)|all_lung(180;0.000547)|Melanoma(134;0.0417)		all cancers(107;3.77e-16)|GBM - Glioblastoma multiforme(94;2.71e-06)		TCACTTTCCAGGTAAAGGATT	0.493000													23	72					0	0	1	0	0
EIF4G3	8672	broad.mit.edu	37	1	21220017	21220017	+	Missense_Mutation	SNP	C	C	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr1:21220017C>T	ENST00000602326.1	-	16	2679	c.2096G>A	c.(2095-2097)gGc>gAc	p.G699D	EIF4G3_ENST00000544689.1_Missense_Mutation_p.G236D|EIF4G3_ENST00000400422.1_Missense_Mutation_p.G693D|EIF4G3_ENST00000537738.1_Missense_Mutation_p.G146D|EIF4G3_ENST00000374933.3_5'UTR|EIF4G3_ENST00000374935.3_Missense_Mutation_p.G413D|EIF4G3_ENST00000374937.3_Missense_Mutation_p.G699D|EIF4G3_ENST00000264211.8_Missense_Mutation_p.G693D|EIF4G3_ENST00000536266.1_Missense_Mutation_p.G297D	NM_001198802.1	NP_001185731.1	O43432	IF4G3_HUMAN	eukaryotic translation initiation factor 4 gamma, 3	693	eIF3/EIF4A-binding (By similarity).	Cleavage; by enterovirus/rhinovirus protease 2A.			interspecies interaction between organisms|regulation of translational initiation|RNA metabolic process	eukaryotic translation initiation factor 4F complex	protein binding|RNA cap binding|translation initiation factor activity			endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(18)|lung(20)|ovary(1)|prostate(4)|skin(3)|stomach(1)|urinary_tract(3)	70		all_lung(284;2.61e-06)|Lung NSC(340;2.81e-06)|Colorectal(325;3.46e-05)|Renal(390;9.67e-05)|Breast(348;0.00149)|Ovarian(437;0.00338)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.023)|COAD - Colon adenocarcinoma(152;5.42e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000327)|GBM - Glioblastoma multiforme(114;0.000696)|Kidney(64;0.0018)|STAD - Stomach adenocarcinoma(196;0.00644)|KIRC - Kidney renal clear cell carcinoma(64;0.0185)|READ - Rectum adenocarcinoma(331;0.124)|Lung(427;0.191)		TACAGGTACGCCTCTTCCACC	0.473000													9	69					0	0	1	0	0
PRKCB	5579	broad.mit.edu	37	16	24231334	24231334	+	Missense_Mutation	SNP	T	T	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr16:24231334T>A	ENST00000321728.7	+	17	2091	c.1916T>A	c.(1915-1917)gTg>gAg	p.V639E	PRKCB_ENST00000303531.7_3'UTR	NM_212535.2	NP_997700.1	P05771	KPCB_HUMAN	protein kinase C, beta	639	AGC-kinase C-terminal.				apoptosis|B cell activation|B cell receptor signaling pathway|intracellular signal transduction|lipoprotein transport|platelet activation|positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|synaptic transmission|transcription, DNA-dependent	cytosol|nucleus|plasma membrane	androgen receptor binding|ATP binding|chromatin binding|histone binding|histone kinase activity (H3-T6 specific)|ligand-dependent nuclear receptor transcription coactivator activity|protein kinase C activity|protein kinase C binding|zinc ion binding			central_nervous_system(3)|large_intestine(1)|lung(2)|ovary(3)	9					Vitamin E(DB00163)	AGACAGCCTGTGGAACTGACC	0.418000													20	41					0	0	1	0	0
SETMAR	6419	broad.mit.edu	37	3	4355405	4355405	+	Missense_Mutation	SNP	C	C	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr3:4355405C>A	ENST00000358065.4	+	2	1047	c.980C>A	c.(979-981)gCc>gAc	p.A327D	SETMAR_ENST00000430981.1_Missense_Mutation_p.A327D|SETMAR_ENST00000425863.1_Missense_Mutation_p.A188D|SUMF1_ENST00000534863.1_Intron	NM_006515.3	NP_006506.3	Q53H47	SETMR_HUMAN	SET domain and mariner transposase fusion gene	314	Histone-lysine N-methyltransferase.				DNA integration|DNA repair|transposition, DNA-mediated	chromosome|nucleus	DNA binding|endonuclease activity|histone-lysine N-methyltransferase activity|transposase activity|zinc ion binding			endometrium(3)|kidney(2)|large_intestine(2)|lung(1)|ovary(1)	9		Melanoma(143;0.0657)		Epithelial(13;0.0025)|OV - Ovarian serous cystadenocarcinoma(96;0.011)|all cancers(10;0.0114)		TGTGGCTCAGCCCCTTCTGTG	0.512000								Chromatin Structure					16	52					2.23348e-06	2.62794e-06	1	1	0
AQP9	366	broad.mit.edu	37	15	58458936	58458936	+	Missense_Mutation	SNP	C	C	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr15:58458936C>A	ENST00000219919.4	+	2	546	c.176C>A	c.(175-177)aCt>aAt	p.T59N	ALDH1A2_ENST00000558231.1_Intron|AQP9_ENST00000536493.1_Missense_Mutation_p.T59N|AQP9_ENST00000558772.1_5'UTR	NM_020980.3	NP_066190.2	O43315	AQP9_HUMAN	aquaporin 9	59					cellular response to cAMP|excretion|immune response|metabolic process|response to mercury ion|response to osmotic stress|water homeostasis	integral to plasma membrane|intracellular membrane-bounded organelle	amine transmembrane transporter activity|carboxylic acid transmembrane transporter activity|glycerol channel activity|porin activity|purine base transmembrane transporter activity|pyrimidine base transmembrane transporter activity|water channel activity			endometrium(1)|kidney(1)|large_intestine(7)|lung(10)|ovary(1)|prostate(1)	21				GBM - Glioblastoma multiforme(80;0.16)		GGGGTCATCACTATCAATGTT	0.463000													15	141					3.45872e-05	3.91089e-05	1	1	0
CDH6	1004	broad.mit.edu	37	5	31322950	31322950	+	Silent	SNP	G	G	C			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr5:31322950G>C	ENST00000265071.2	+	12	2173	c.1908G>C	c.(1906-1908)ctG>ctC	p.L636L		NM_004932.3	NP_004923.1	P55285	CADH6_HUMAN	cadherin 6, type 2, K-cadherin (fetal kidney)	636					adherens junction organization|cell junction assembly|homophilic cell adhesion	cytoplasm|integral to membrane|nucleus|plasma membrane	calcium ion binding			NS(3)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(42)|ovary(4)|prostate(6)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(1)	77						TTGCAGCTCTGAGGCGGCAGC	0.453000													19	106					0	0	1	0	0
M1AP	130951	broad.mit.edu	37	2	74867395	74867395	+	Translation_Start_Site	SNP	G	G	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr2:74867395G>T	ENST00000358434.2	-	0	124				M1AP_ENST00000290536.5_Missense_Mutation_p.P3H|M1AP_ENST00000409585.1_Missense_Mutation_p.P3H|M1AP_ENST00000536235.1_Missense_Mutation_p.P3H					meiosis 1 associated protein																		AGTTCGCCCAGGATGCATGGC	0.507000													7	40					8.12818e-05	8.98474e-05	1	1	0
SPHKAP	80309	broad.mit.edu	37	2	228882609	228882609	+	Silent	SNP	C	C	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr2:228882609C>A	ENST00000392056.3	-	7	3007	c.2961G>T	c.(2959-2961)ggG>ggT	p.G987G	SPHKAP_ENST00000344657.5_Silent_p.G987G	NM_001142644.1	NP_001136116.1	Q2M3C7	SPKAP_HUMAN	SPHK1 interactor, AKAP domain containing	987						cytoplasm	protein binding			NS(5)|breast(5)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(25)|lung(86)|ovary(6)|pancreas(1)|prostate(6)|skin(17)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	185		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;8.17e-11)|all cancers(144;7.92e-08)|Lung(261;0.0168)|LUSC - Lung squamous cell carcinoma(224;0.0232)		CGGTCCCGCTCCCCTGGCTCT	0.532000													28	103					8.58068e-18	1.24603e-17	1	1	0
NR2C2	7182	broad.mit.edu	37	3	15057714	15057714	+	Missense_Mutation	SNP	G	G	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr3:15057714G>T	ENST00000425241.1	+	4	691	c.329G>T	c.(328-330)cGg>cTg	p.R110L	NR2C2_ENST00000323373.6_Missense_Mutation_p.R129L|NR2C2_ENST00000393102.3_Missense_Mutation_p.R110L|NR2C2_ENST00000406272.2_Missense_Mutation_p.R110L			P49116	NR2C2_HUMAN	nuclear receptor subfamily 2, group C, member 2	110					cell differentiation|nervous system development|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|spermatogenesis	nucleoplasm	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|transcription coactivator activity|zinc ion binding			breast(1)|endometrium(2)|large_intestine(5)|lung(5)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	16						GACGTCCAGCGGCCCCAGGTG	0.507000													17	90					1.67942e-08	2.12841e-08	1	1	0
ALDH9A1	223	broad.mit.edu	37	1	165652284	165652284	+	Missense_Mutation	SNP	G	G	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr1:165652284G>A	ENST00000354775.4	-	3	695	c.391C>T	c.(391-393)Cgc>Tgc	p.R131C	ALDH9A1_ENST00000538148.1_Missense_Mutation_p.R37C|ALDH9A1_ENST00000461664.1_5'UTR	NM_000696.3	NP_000687.3	P49189	AL9A1_HUMAN	aldehyde dehydrogenase 9 family, member A1	107					carnitine biosynthetic process|cellular aldehyde metabolic process|hormone metabolic process|neurotransmitter biosynthetic process	cytosol|plasma membrane	3-chloroallyl aldehyde dehydrogenase activity|4-trimethylammoniobutyraldehyde dehydrogenase activity|aldehyde dehydrogenase (NAD) activity|aminobutyraldehyde dehydrogenase activity			endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(7)|prostate(1)|skin(2)|urinary_tract(1)	21	all_hematologic(923;0.0773)|Acute lymphoblastic leukemia(8;0.155)				NADH(DB00157)	ATGTCCAAGCGGGCCTCAAAG	0.483000													35	132					0	0	1	0	0
ABI3BP	25890	broad.mit.edu	37	3	100617659	100617659	+	Missense_Mutation	SNP	G	G	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr3:100617659G>T	ENST00000471714.1	-	4	538	c.429C>A	c.(427-429)ttC>ttA	p.F143L	ABI3BP_ENST00000495063.1_Missense_Mutation_p.F143L|ABI3BP_ENST00000284322.5_Missense_Mutation_p.F143L			Q7Z7G0	TARSH_HUMAN	ABI family, member 3 (NESH) binding protein	143	Fibronectin type-III 1.					extracellular space				central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|lung(18)|ovary(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	50						GGTTGATGAGGAAACCCCAGG	0.488000													13	98					0.00136819	0.00145685	1	1	0
PHF12	57649	broad.mit.edu	37	17	27248797	27248797	+	Missense_Mutation	SNP	T	T	C			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr17:27248797T>C	ENST00000577226.1	-	5	1091	c.745A>G	c.(745-747)Acc>Gcc	p.T249A	PHF12_ENST00000582655.1_5'UTR|PHF12_ENST00000332830.4_Missense_Mutation_p.T249A|PHF12_ENST00000268756.3_Missense_Mutation_p.T249A			Q96QT6	PHF12_HUMAN	PHD finger protein 12	249	Interaction with SIN3A.				negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	transcriptional repressor complex	protein binding|zinc ion binding			breast(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(6)|lung(8)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	30	all_cancers(5;1.95e-14)|all_epithelial(6;5e-18)|Lung NSC(42;0.01)		Epithelial(11;1.64e-05)|all cancers(11;7.47e-05)|BRCA - Breast invasive adenocarcinoma(11;9.79e-05)			TTCCCTGTGGTTTCCTCCTTT	0.428000													11	91					0	0	1	0	0
MC3R	4159	broad.mit.edu	37	20	54824314	54824314	+	Missense_Mutation	SNP	G	G	C			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr20:54824314G>C	ENST00000243911.2	+	1	527	c.415G>C	c.(415-417)Gcc>Ccc	p.A139P		NM_019888.3	NP_063941.3	P41968	MC3R_HUMAN	melanocortin 3 receptor	176					activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|positive regulation of cAMP biosynthetic process	integral to plasma membrane	melanocyte-stimulating hormone receptor activity|neuropeptide binding|protein binding			breast(2)|endometrium(1)|kidney(3)|large_intestine(3)|lung(13)|ovary(3)|skin(1)	26			Colorectal(105;0.202)			CCTGGCCATCGCCGTCGACAG	0.572000													17	127					0	0	1	0	0
CCDC40	55036	broad.mit.edu	37	17	78013835	78013835	+	Missense_Mutation	SNP	A	A	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr17:78013835A>T	ENST00000397545.4	+	3	345	c.318A>T	c.(316-318)caA>caT	p.Q106H	CCDC40_ENST00000269318.5_Missense_Mutation_p.Q106H|CCDC40_ENST00000374877.3_Missense_Mutation_p.Q106H|CCDC40_ENST00000374876.4_Missense_Mutation_p.Q106H	NM_017950.3	NP_060420.2	Q4G0X9	CCD40_HUMAN	coiled-coil domain containing 40	106					axonemal dynein complex assembly|ciliary cell motility|cilium movement involved in determination of left/right asymmetry|flagellar cell motility	cilium|cytoplasm				NS(1)|breast(1)|endometrium(4)|kidney(4)|large_intestine(7)|lung(12)|ovary(4)|prostate(1)|skin(2)|stomach(1)|urinary_tract(1)	38	all_neural(118;0.167)		OV - Ovarian serous cystadenocarcinoma(97;0.0292)|BRCA - Breast invasive adenocarcinoma(99;0.149)			CGGAAGGGCAAATCAGTGCTG	0.522000													13	92					0	0	1	0	0
CASP1	834	broad.mit.edu	37	11	104905008	104905008	+	Missense_Mutation	SNP	C	C	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr11:104905008C>A	ENST00000533400.1	-	2	236	c.201G>T	c.(199-201)caG>caT	p.Q67H	CASP1_ENST00000353247.5_Intron|CASP1_ENST00000598974.1_Missense_Mutation_p.Q67H|CASP1_ENST00000594519.1_Intron|CASP1_ENST00000531166.1_Intron|CASP1_ENST00000528974.1_Missense_Mutation_p.Q28H|CASP1_ENST00000593315.1_Missense_Mutation_p.Q67H|CASP1_ENST00000527979.1_Missense_Mutation_p.Q51H|CASP1_ENST00000534497.1_Intron|CASP1_ENST00000526568.1_Intron|CASP1_ENST00000525825.1_Missense_Mutation_p.Q67H|CASP1_ENST00000446369.1_Intron|CASP1_ENST00000436863.3_Missense_Mutation_p.Q67H|CASP1_ENST00000415981.2_Intron|CASP1_ENST00000393136.4_Missense_Mutation_p.Q67H	NM_001257118.1	NP_001244047.1	P29466	CASP1_HUMAN	caspase 1, apoptosis-related cysteine peptidase	67	CARD.				cellular response to mechanical stimulus|cellular response to organic substance|positive regulation of I-kappaB kinase/NF-kappaB cascade|proteolysis|signal transduction	cytosol	caspase activator activity|cysteine-type endopeptidase activity|protein binding			haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|ovary(2)	5		Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0017)|Melanoma(852;0.0047)		BRCA - Breast invasive adenocarcinoma(274;0.000525)|Epithelial(105;0.0128)|all cancers(92;0.0482)	Minocycline(DB01017)|Penicillamine(DB00859)	TTTGGCATGCCTGTGCCCCTT	0.458000													42	228					1.67305e-13	2.33327e-13	1	1	0
YLPM1	56252	broad.mit.edu	37	14	75265281	75265281	+	Missense_Mutation	SNP	C	C	G			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr14:75265281C>G	ENST00000325680.7	+	5	3405	c.3281C>G	c.(3280-3282)cCa>cGa	p.P1094R	YLPM1_ENST00000552421.1_Intron|YLPM1_ENST00000238571.3_Missense_Mutation_p.P899R	NM_019589.2	NP_062535.2	P49750	YLPM1_HUMAN	YLP motif containing 1	899	Arg-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear speck				breast(4)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(12)|lung(24)|ovary(3)|pancreas(1)|prostate(1)|skin(1)|urinary_tract(1)	62			KIRC - Kidney renal clear cell carcinoma(43;0.238)	BRCA - Breast invasive adenocarcinoma(234;0.00162)		GAGAAAGTGCCAGGTGGTCTT	0.592000													23	52					0	0	1	0	0
PAQR7	164091	broad.mit.edu	37	1	26189412	26189412	+	Missense_Mutation	SNP	G	G	C			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr1:26189412G>C	ENST00000374296.3	-	2	1585	c.919C>G	c.(919-921)Ctg>Gtg	p.L307V	RP1-125I3.2_ENST00000455431.1_RNA	NM_178422.5	NP_848509.1	Q86WK9	MPRA_HUMAN	progestin and adipoQ receptor family member VII	307					cell differentiation|multicellular organismal development|oogenesis	integral to membrane|plasma membrane	receptor activity|steroid binding			breast(3)|endometrium(1)|large_intestine(2)|lung(2)|upper_aerodigestive_tract(1)	9		Colorectal(325;3.46e-05)|Lung NSC(340;0.00038)|all_lung(284;0.00051)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0155)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0505)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;2.16e-25)|Colorectal(126;2.96e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.000724)|BRCA - Breast invasive adenocarcinoma(304;0.000965)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.0136)|READ - Rectum adenocarcinoma(331;0.0649)		TGCGTGTGCAGAGGCTCATAG	0.597000													17	83					0	0	1	0	0
TP53	7157	broad.mit.edu	37	17	7578461	7578461	+	Missense_Mutation	SNP	C	C	G	rs121912654		TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr17:7578461C>G	ENST00000420246.2	-	5	601	c.469G>C	c.(469-471)Gtc>Ctc	p.V157L	TP53_ENST00000455263.2_Missense_Mutation_p.V157L|TP53_ENST00000445888.2_Missense_Mutation_p.V157L|TP53_ENST00000269305.4_Missense_Mutation_p.V157L|TP53_ENST00000413465.2_Missense_Mutation_p.V157L|TP53_ENST00000359597.4_Missense_Mutation_p.V157L	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	157	Interaction with AXIN1 (By similarity).|Interaction with HIPK1 (By similarity).|Required for interaction with FBXO42.		V -> A (in sporadic cancers; somatic mutation).|V -> D (in sporadic cancers; somatic mutation).|V -> F (in sporadic cancers; somatic mutation).|V -> G (in sporadic cancers; somatic mutation).|V -> I (in sporadic cancers; somatic mutation).|V -> L (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.V157F(161)|p.V157I(10)|p.0?(8)|p.V157L(6)|p.V64F(6)|p.V25F(6)|p.R156_I162delRVRAMAI(2)|p.T155fs*23(2)|p.V157del(2)|p.V157fs*9(2)|p.P153fs*22(2)|p.V157fs*22(2)|p.V157fs*24(2)|p.V157_C176del20(1)|p.R156_A161delRVRAMA(1)|p.P151_V173del23(1)|p.R156_V157del(1)|p.R156_V157insV(1)|p.R156_R158delRVR(1)|p.R156fs*12(1)|p.R156fs*18(1)|p.R156_A161del(1)|p.V157_M160delVRAM(1)|p.D148fs*23(1)|p.V157_R158delVR(1)|p.S149fs*72(1)|p.T155_A161delTRVRAMA(1)|p.G154fs*22(1)|p.R156fs*20(1)|p.V157_I162delVRAMAI(1)|p.V157fs*23(1)|p.V157fs*21(1)|p.V157fs*25(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		ATGGCGCGGACGCGGGTGCCG	0.617000		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			12	51					0	0	1	0	0
CHD4	1108	broad.mit.edu	37	12	6709382	6709382	+	Splice_Site	SNP	C	C	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr12:6709382C>T	ENST00000309577.6	-	9	1406		c.e9+1		CHD4_ENST00000544040.1_Splice_Site|CHD4_ENST00000357008.2_Splice_Site|CHD4_ENST00000544484.1_Splice_Site			Q14839	CHD4_HUMAN	chromodomain helicase DNA binding protein 4						chromatin modification|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	microtubule organizing center|NuRD complex	ATP binding|ATP-dependent DNA helicase activity|DNA binding|zinc ion binding			central_nervous_system(2)	2						CAGACACTCACGCAGTGTGGG	0.582000													11	130					0	0	1	0	0
FCGBP	8857	broad.mit.edu	37	19	40430489	40430489	+	Missense_Mutation	SNP	C	C	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr19:40430489C>T	ENST00000221347.6	-	3	1461	c.1454G>A	c.(1453-1455)gGc>gAc	p.G485D		NM_003890.2	NP_003881.2	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein	485	VWFD 1.					extracellular region	protein binding			NS(3)|autonomic_ganglia(1)|breast(7)|central_nervous_system(5)|endometrium(13)|kidney(9)|large_intestine(27)|lung(49)|ovary(8)|pancreas(3)|prostate(13)|skin(9)|stomach(9)|upper_aerodigestive_tract(6)|urinary_tract(3)	165	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			GTAGCGACGGCCGTCGAAGGT	0.677000													8	11					0	0	1	0	0
C11orf40	143501	broad.mit.edu	37	11	4594654	4594654	+	Missense_Mutation	SNP	C	C	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr11:4594654C>T	ENST00000307616.1	-	2	189	c.190G>A	c.(190-192)Gat>Aat	p.D64N		NM_144663.1	NP_653264.1	Q8WZ69	CK040_HUMAN	chromosome 11 open reading frame 40	64										large_intestine(3)|lung(1)|ovary(2)|stomach(1)	7		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;4.28e-12)|BRCA - Breast invasive adenocarcinoma(625;0.0288)|LUSC - Lung squamous cell carcinoma(625;0.192)		ACATCCTTATCTAAGTTAAAG	0.428000													10	48					0	0	1	0	0
OR2L8	391190	broad.mit.edu	37	1	248112706	248112706	+	Missense_Mutation	SNP	A	A	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr1:248112706A>T	ENST00000357191.3	+	1	547	c.547A>T	c.(547-549)Atg>Ttg	p.M183L	OR2L13_ENST00000366478.2_Intron	NM_001001963.1	NP_001001963.1	Q8NGY9	OR2L8_HUMAN	olfactory receptor, family 2, subfamily L, member 8 (gene/pseudogene)	183					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(3)|large_intestine(3)|lung(30)|ovary(1)|prostate(1)|skin(3)	42	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0152)			TGTCCCAGCAATGGTGACTCT	0.468000													16	115					0	0	1	0	0
PKHD1	5314	broad.mit.edu	37	6	51618136	51618136	+	Missense_Mutation	SNP	G	G	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr6:51618136G>A	ENST00000371117.3	-	57	9088	c.8813C>T	c.(8812-8814)aCg>aTg	p.T2938M	PKHD1_ENST00000340994.4_Missense_Mutation_p.T2938M	NM_138694.3	NP_619639.3	P08F94	PKHD1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)	2938			T -> M.		cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			NS(1)|autonomic_ganglia(1)|breast(8)|central_nervous_system(5)|cervix(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(4)|kidney(11)|large_intestine(59)|lung(139)|ovary(16)|prostate(8)|skin(20)|soft_tissue(1)|stomach(2)|upper_aerodigestive_tract(7)|urinary_tract(5)	304	Lung NSC(77;0.0605)					GCCATCCTCCGTGACATGTAC	0.458000													27	87					0	0	1	0	0
MKI67	4288	broad.mit.edu	37	10	129903908	129903908	+	Missense_Mutation	SNP	G	G	C			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr10:129903908G>C	ENST00000368654.3	-	13	6571	c.6196C>G	c.(6196-6198)Cct>Gct	p.P2066A	MKI67_ENST00000368653.3_Missense_Mutation_p.P1706A	NM_002417.4	NP_002408.3	P46013	KI67_HUMAN	marker of proliferation Ki-67	2066	16 X 122 AA approximate repeats.				cell proliferation	nucleolus	ATP binding|protein C-terminus binding			NS(2)|autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(5)|kidney(7)|large_intestine(30)|lung(64)|ovary(4)|pancreas(1)|prostate(4)|skin(2)|soft_tissue(1)|stomach(10)|upper_aerodigestive_tract(4)|urinary_tract(4)	159		all_epithelial(44;2.12e-05)|all_lung(145;0.00679)|Lung NSC(174;0.00998)|all_neural(114;0.0936)|Colorectal(57;0.14)|Breast(234;0.166)|Melanoma(40;0.203)				TCTTCCTTAGGTGTTCTTGGC	0.493000													56	239					0	0	1	0	0
PDE7B	27115	broad.mit.edu	37	6	136512891	136512891	+	Missense_Mutation	SNP	A	A	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr6:136512891A>T	ENST00000308191.6	+	13	1569	c.1266A>T	c.(1264-1266)agA>agT	p.R422S	RP13-143G15.4_ENST00000591521.1_RNA|RP13-143G15.4_ENST00000585946.1_RNA|RP13-143G15.4_ENST00000417643.1_RNA	NM_018945.3	NP_061818.1	Q9NP56	PDE7B_HUMAN	phosphodiesterase 7B	422					signal transduction|synaptic transmission	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding			breast(1)|kidney(1)|large_intestine(5)|lung(7)|ovary(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	21	Colorectal(23;0.24)			OV - Ovarian serous cystadenocarcinoma(155;0.0136)|GBM - Glioblastoma multiforme(68;0.0147)	Dyphylline(DB00651)|Ketotifen(DB00920)	GGCAGCACAGAAGCAGGGGCA	0.662000													7	18					0	0	1	0	0
ANGPTL7	10218	broad.mit.edu	37	1	11249764	11249764	+	Missense_Mutation	SNP	C	C	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr1:11249764C>T	ENST00000376819.3	+	1	367	c.128C>T	c.(127-129)gCc>gTc	p.A43V	MTOR_ENST00000361445.4_Intron	NM_021146.2	NP_066969.1	O43827	ANGL7_HUMAN	angiopoietin-like 7	43					response to oxidative stress|signal transduction	extracellular region	receptor binding			endometrium(2)|kidney(1)|large_intestine(1)|lung(3)|skin(2)|stomach(1)	10	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.000818)|all_lung(284;0.00105)|Colorectal(325;0.0062)|Breast(348;0.0139)|Hepatocellular(190;0.0305)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;1.39e-06)|COAD - Colon adenocarcinoma(227;0.000244)|BRCA - Breast invasive adenocarcinoma(304;0.000294)|Kidney(185;0.000728)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0487)		CTCAAAGCGGCCAACTGCTGT	0.567000													13	66					0	0	1	0	0
ARHGAP27	201176	broad.mit.edu	37	17	43481983	43481983	+	Missense_Mutation	SNP	C	C	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr17:43481983C>T	ENST00000532038.1	-	4	848	c.713G>A	c.(712-714)cGa>cAa	p.R238Q	ARHGAP27_ENST00000532891.2_Missense_Mutation_p.R438Q|ARHGAP27_ENST00000442348.1_Intron|ARHGAP27_ENST00000428638.1_Missense_Mutation_p.R438Q|ARHGAP27_ENST00000528384.1_Intron|ARHGAP27_ENST00000455881.1_Missense_Mutation_p.R97Q|ARHGAP27_ENST00000376922.2_Missense_Mutation_p.R97Q			Q6ZUM4	RHG27_HUMAN	Rho GTPase activating protein 27	438					positive regulation of Cdc42 GTPase activity|receptor-mediated endocytosis|signal transduction	cytoplasm|membrane	Rac GTPase activator activity|SH3 domain binding			endometrium(4)|large_intestine(9)|lung(3)|skin(1)	17	Renal(3;0.0405)					CAGCTCCCATCGAACAGAGGA	0.592000													9	24					0	0	1	0	0
KIF21B	23046	broad.mit.edu	37	1	200977976	200977976	+	Missense_Mutation	SNP	C	C	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr1:200977976C>A	ENST00000332129.2	-	3	684	c.368G>T	c.(367-369)gGc>gTc	p.G123V	KIF21B_ENST00000461742.2_Missense_Mutation_p.G123V|KIF21B_ENST00000360529.5_Missense_Mutation_p.G123V|KIF21B_ENST00000422435.2_Missense_Mutation_p.G123V	NM_001252102.1|NM_001252103.1|NM_017596.3	NP_001239031.1|NP_001239032.1|NP_060066.2	O75037	KI21B_HUMAN	kinesin family member 21B	123	Kinesin-motor.				microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(15)|kidney(4)|large_intestine(8)|liver(1)|lung(27)|ovary(3)|pancreas(1)|prostate(5)|skin(8)|stomach(2)|urinary_tract(2)	83						CTCGGCAATGCCCCCAAAGAG	0.642000													45	95					5.48756e-27	8.32421e-27	1	1	0
CELF1	10658	broad.mit.edu	37	11	47498939	47498939	+	Missense_Mutation	SNP	C	C	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr11:47498939C>A	ENST00000395290.2	-	8	808	c.799G>T	c.(799-801)Gct>Tct	p.A267S	CELF1_ENST00000361904.3_Missense_Mutation_p.A264S|CELF1_ENST00000358597.3_Missense_Mutation_p.A268S|CELF1_ENST00000395292.2_Missense_Mutation_p.A264S|CELF1_ENST00000310513.5_Missense_Mutation_p.A264S|CELF1_ENST00000532048.1_Missense_Mutation_p.A294S|CELF1_ENST00000531165.1_Missense_Mutation_p.A295S	NM_001025596.2|NM_001172640.1	NP_001020767.1|NP_001166111.1	Q92879	CELF1_HUMAN	CUGBP, Elav-like family member 1	268					embryo development|mRNA splice site selection|regulation of RNA splicing|RNA interference	cytoplasm|nucleus|ribonucleoprotein complex	BRE binding|mRNA binding|nucleotide binding|translation repressor activity, nucleic acid binding			central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(8)|ovary(2)	18						GCTGCAGCAGCTAGTGCAGCC	0.483000													17	62					3.52763e-06	4.12603e-06	1	1	0
OR5M8	219484	broad.mit.edu	37	11	56258729	56258729	+	Missense_Mutation	SNP	C	C	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr11:56258729C>A	ENST00000327216.2	-	1	142	c.118G>T	c.(118-120)Ggg>Tgg	p.G40W		NM_001005282.1	NP_001005282.1	Q8NGP6	OR5M8_HUMAN	olfactory receptor, family 5, subfamily M, member 8	40					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(4)|lung(22)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	37	Esophageal squamous(21;0.00352)					CCAAGGTTCCCTGCCACCGTG	0.522000													24	113					2.21704e-12	3.01933e-12	1	1	0
RAB3GAP1	22930	broad.mit.edu	37	2	135911417	135911417	+	Missense_Mutation	SNP	C	C	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr2:135911417C>T	ENST00000264158.8	+	19	2303	c.2260C>T	c.(2260-2262)Ctc>Ttc	p.L754F	ZRANB3_ENST00000412849.1_Intron|RAB3GAP1_ENST00000487003.1_3'UTR|RAB3GAP1_ENST00000442034.1_Missense_Mutation_p.L754F|RAB3GAP1_ENST00000539493.1_Missense_Mutation_p.L710F	NM_012233.2	NP_036365.1	Q15042	RB3GP_HUMAN	RAB3 GTPase activating protein subunit 1 (catalytic)	754						centrosome|nucleus|soluble fraction	Rab GTPase activator activity|Rab GTPase binding	p.L754F(1)		breast(1)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(5)|liver(1)|lung(10)|ovary(1)|prostate(1)|skin(3)|urinary_tract(1)	32				BRCA - Breast invasive adenocarcinoma(221;0.117)		GCAAAGGAGACTCTTTGATGA	0.423000													9	68					0	0	1	0	0
C8B	732	broad.mit.edu	37	1	57399130	57399130	+	Missense_Mutation	SNP	G	G	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr1:57399130G>T	ENST00000543257.1	-	11	1840	c.1274C>A	c.(1273-1275)aCa>aAa	p.T425K	C8B_ENST00000371237.4_Missense_Mutation_p.T477K|C8B_ENST00000535057.1_Missense_Mutation_p.T415K	NM_001278543.1	NP_001265472.1	P07358	CO8B_HUMAN	complement component 8, beta polypeptide	477	MACPF.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis	membrane attack complex				breast(2)|central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(11)|liver(1)|lung(20)|ovary(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)	52						GGCAAAATCTGTGGCTGTCAC	0.448000													8	44					0.00307968	0.00324766	1	1	0
PNLIPRP2	5408	broad.mit.edu	37	10	118385457	118385457	+	RNA	SNP	C	C	G			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr10:118385457C>G	ENST00000537242.1	+	0	231				PNLIPRP2_ENST00000298771.7_RNA|PNLIPRP2_ENST00000433618.4_RNA	NM_005396.4	NP_005387.2	P54317	LIPR2_HUMAN	pancreatic lipase-related protein 2						galactolipid catabolic process|lipid digestion|phospholipid catabolic process|triglyceride metabolic process	extracellular space	acylglycerol lipase activity|calcium ion binding|galactolipase activity|phospholipase activity|triglyceride lipase activity			endometrium(1)|large_intestine(1)|lung(11)|prostate(3)	16				all cancers(201;0.015)		ATTAAACCAGCTAATCACTGG	0.443000													7	29					0	0	1	0	0
INVS	27130	broad.mit.edu	37	9	103009039	103009039	+	Missense_Mutation	SNP	A	A	G			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr9:103009039A>G	ENST00000262457.2	+	8	1233	c.1048A>G	c.(1048-1050)Att>Gtt	p.I350V	INVS_ENST00000262456.2_Missense_Mutation_p.I350V|INVS_ENST00000541287.1_Missense_Mutation_p.I254V	NM_014425.3	NP_055240.2	Q9Y283	INVS_HUMAN	inversin	350					negative regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	cytoplasm|membrane|microtubule|nucleus|spindle	calmodulin binding			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(5)|ovary(4)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	31		Acute lymphoblastic leukemia(62;0.056)				GGACATAGATATTAACATGGC	0.398000													38	83					0	0	1	0	0
ELAVL2	1993	broad.mit.edu	37	9	23692776	23692776	+	Missense_Mutation	SNP	C	C	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr9:23692776C>A	ENST00000397312.2	-	7	1133	c.859G>T	c.(859-861)Gca>Tca	p.A287S	ELAVL2_ENST00000380117.1_Missense_Mutation_p.A287S|ELAVL2_ENST00000380110.4_Missense_Mutation_p.A317S|ELAVL2_ENST00000223951.6_Missense_Mutation_p.A274S|ELAVL2_ENST00000544538.1_Missense_Mutation_p.A287S	NM_004432.3	NP_004423.2	Q12926	ELAV2_HUMAN	ELAV like neuron-specific RNA binding protein 2	287	RRM 3.				regulation of transcription, DNA-dependent		mRNA 3'-UTR binding|nucleotide binding|protein binding			breast(1)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(20)|ovary(2)|skin(1)|stomach(1)|urinary_tract(1)	39				GBM - Glioblastoma multiforme(1;2.18e-156)|Lung(42;2.15e-28)|LUSC - Lung squamous cell carcinoma(38;1.02e-19)		CTCTCATCTGCGTCAGGAGCC	0.468000													34	64					9.04072e-19	1.32454e-18	1	1	0
CACNA1G	8913	broad.mit.edu	37	17	48696263	48696263	+	Missense_Mutation	SNP	G	G	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr17:48696263G>T	ENST00000352832.5	+	31	5945	c.5573G>T	c.(5572-5574)tGg>tTg	p.W1858L	CACNA1G_ENST00000507609.1_Missense_Mutation_p.W1885L|CACNA1G_ENST00000507336.1_Missense_Mutation_p.W1881L|CACNA1G_ENST00000505165.1_Missense_Mutation_p.W1892L|CACNA1G_ENST00000514079.1_Missense_Mutation_p.W1899L|CACNA1G_ENST00000515765.1_Missense_Mutation_p.W1881L|CACNA1G_ENST00000510366.1_Missense_Mutation_p.W1840L|CACNA1G_ENST00000515411.1_Missense_Mutation_p.W1874L|CACNA1G_ENST00000515165.1_Missense_Mutation_p.W1892L|CACNA1G_ENST00000503485.1_Missense_Mutation_p.W1858L|CACNA1G_ENST00000512389.1_Missense_Mutation_p.W1881L|CACNA1G_ENST00000358244.5_Missense_Mutation_p.W1858L|CACNA1G_ENST00000514717.1_Missense_Mutation_p.W1835L|CACNA1G_ENST00000514181.1_Missense_Mutation_p.W1867L|CACNA1G_ENST00000359106.5_Missense_Mutation_p.W1892L|CACNA1G_ENST00000510115.1_Missense_Mutation_p.W1858L|CACNA1G_ENST00000513964.1_Missense_Mutation_p.W1847L|CACNA1G_ENST00000513689.2_Missense_Mutation_p.W1847L|CACNA1G_ENST00000354983.4_Missense_Mutation_p.W1858L|CACNA1G_ENST00000442258.2_Missense_Mutation_p.W1851L|CACNA1G_ENST00000429973.2_Missense_Mutation_p.W1874L|CACNA1G_ENST00000507896.1_Missense_Mutation_p.W1881L|CACNA1G_ENST00000360761.4_Missense_Mutation_p.W1869L|CACNA1G_ENST00000502264.1_Missense_Mutation_p.W1869L|CACNA1G_ENST00000507510.2_Missense_Mutation_p.W1892L	NM_001256334.1|NM_198376.2|NM_198379.2|NM_198387.2|NM_198388.2	NP_001243263.1|NP_938190.1|NP_938193.1|NP_938201.1|NP_938202.1	O43497	CAC1G_HUMAN	calcium channel, voltage-dependent, T type, alpha 1G subunit	1892					axon guidance	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(5)|cervix(1)|endometrium(13)|kidney(5)|lung(23)	47	Breast(11;6.7e-17)		BRCA - Breast invasive adenocarcinoma(22;7.52e-09)		Ethosuximide(DB00593)|Flunarizine(DB04841)|Levetiracetam(DB01202)|Mibefradil(DB01388)|Pimozide(DB01100)|Trimethadione(DB00347)|Verapamil(DB00661)|Zonisamide(DB00909)	CCCTTCCTCTGGCCTGGGGTC	0.692000													8	16					1.06961e-07	1.31665e-07	1	1	0
PPIL4	85313	broad.mit.edu	37	6	149833291	149833291	+	Splice_Site	SNP	C	C	G			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr6:149833291C>G	ENST00000253329.2	-	12	1259	c.1227_splice	c.e12+1	p.Q409_splice	PPIL4_ENST00000340881.2_Splice_Site_p.R42_splice	NM_139126.3	NP_624311.1	Q8WUA2	PPIL4_HUMAN	peptidylprolyl isomerase (cyclophilin)-like 4	409					protein folding	nucleus	nucleotide binding|peptidyl-prolyl cis-trans isomerase activity|RNA binding			endometrium(2)|kidney(4)|large_intestine(1)|lung(4)|prostate(1)|urinary_tract(1)	13		Ovarian(120;0.0164)		OV - Ovarian serous cystadenocarcinoma(155;1.11e-11)|GBM - Glioblastoma multiforme(68;0.0885)		TTAGAGGTACCTGATTAGTAT	0.348000													14	82					0	0	1	0	0
CMYA5	202333	broad.mit.edu	37	5	79033880	79033880	+	Missense_Mutation	SNP	G	G	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr5:79033880G>T	ENST00000446378.2	+	2	9323	c.9292G>T	c.(9292-9294)Gtg>Ttg	p.V3098L		NM_153610.3	NP_705838.3	Q8N3K9	CMYA5_HUMAN	cardiomyopathy associated 5	3098				PQKLNVEEKLSKEVTEETISFPVSSVESALEHEYDLVKLDE -> SFKTIPLPDDSETVACHKTLKSRLEDEKVTPLKENKQK ETQ (in Ref. 3; AAH62664).		perinuclear region of cytoplasm				NS(2)|breast(4)|central_nervous_system(1)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(4)|large_intestine(37)|lung(34)|ovary(6)|pancreas(2)|prostate(5)|skin(5)|stomach(11)|upper_aerodigestive_tract(3)|urinary_tract(1)	128		Lung NSC(167;0.00296)|all_lung(232;0.00327)|Ovarian(174;0.0262)		OV - Ovarian serous cystadenocarcinoma(54;9.85e-46)|Epithelial(54;3.38e-40)|all cancers(79;3.43e-35)		AGTAAGTTCAGTGGAAAGTGC	0.383000													7	23					0.000157383	0.000172422	1	1	0
ANGEL1	23357	broad.mit.edu	37	14	77257685	77257685	+	Missense_Mutation	SNP	G	G	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr14:77257685G>A	ENST00000251089.2	-	8	1755	c.1643C>T	c.(1642-1644)tCt>tTt	p.S548F	ANGEL1_ENST00000557179.1_Missense_Mutation_p.S113F	NM_015305.3	NP_056120.2	Q9UNK9	ANGE1_HUMAN	angel homolog 1 (Drosophila)	548										breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|large_intestine(2)|lung(9)|ovary(2)|skin(1)|stomach(1)|urinary_tract(1)	22			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0285)		CTCAAGGACAGACTCAGCCCA	0.498000													13	61					0	0	1	0	0
CCDC150	284992	broad.mit.edu	37	2	197559881	197559881	+	Missense_Mutation	SNP	G	G	C			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr2:197559881G>C	ENST00000389175.4	+	14	1756	c.1621G>C	c.(1621-1623)Ggg>Cgg	p.G541R	CCDC150_ENST00000272831.7_Missense_Mutation_p.G209R|CCDC150_ENST00000472405.2_3'UTR	NM_001080539.1	NP_001074008.1	Q8NCX0	CC150_HUMAN	coiled-coil domain containing 150	541										breast(3)|endometrium(6)|kidney(1)|large_intestine(6)|lung(14)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	33						TGATTACCATGGGGTGGGTAT	0.388000													17	39					0	0	1	0	0
TSKS	60385	broad.mit.edu	37	19	50266451	50266451	+	Silent	SNP	G	G	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr19:50266451G>T	ENST00000246801.3	-	1	136	c.54C>A	c.(52-54)gcC>gcA	p.A18A		NM_021733.1	NP_068379.1	Q9UJT2	TSKS_HUMAN	testis-specific serine kinase substrate	18							protein binding			breast(3)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(12)|liver(1)|lung(9)|prostate(3)|skin(3)	38		all_lung(116;3.24e-07)|Lung NSC(112;1.6e-06)|all_neural(266;0.0459)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.00153)|GBM - Glioblastoma multiforme(134;0.0145)		GGGTGTCCCCGGCCTCATGGA	0.647000													40	96					6.2361e-21	9.27421e-21	1	1	0
PITPNM1	9600	broad.mit.edu	37	11	67261793	67261793	+	Silent	SNP	C	C	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr11:67261793C>T	ENST00000356404.3	-	19	3006	c.2781G>A	c.(2779-2781)gtG>gtA	p.V927V	PITPNM1_ENST00000534749.1_Silent_p.V927V|PITPNM1_ENST00000526450.1_5'UTR|PITPNM1_ENST00000436757.2_Silent_p.V926V	NM_001130848.1|NM_004910.2	NP_001124320.1|NP_004901.2	O00562	PITM1_HUMAN	phosphatidylinositol transfer protein, membrane-associated 1	927					brain development|lipid metabolic process|phototransduction|protein transport	cleavage furrow|endoplasmic reticulum membrane|Golgi cisterna membrane|lipid particle|membrane fraction|midbody	metal ion binding|phosphatidylinositol transporter activity			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(2)|liver(1)|lung(4)|ovary(1)|prostate(1)|skin(3)	18						GGCCCTCGCACACCACCGTGT	0.672000													11	53					0	0	1	0	0
FBXO44	93611	broad.mit.edu	37	1	11718921	11718921	+	Missense_Mutation	SNP	G	G	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr1:11718921G>T	ENST00000376770.1	+	6	1115	c.617G>T	c.(616-618)tGg>tTg	p.W206L	FBXO44_ENST00000376760.1_Silent_p.V164V|FBXO44_ENST00000251546.4_Silent_p.V164V|FBXO44_ENST00000376762.4_Silent_p.V164V|FBXO44_ENST00000376768.1_Silent_p.V196V|FBXO44_ENST00000251547.5_Missense_Mutation_p.W206L	NM_001014765.1	NP_001014765.1	Q9H4M3	FBX44_HUMAN	F-box protein 44	206	FBA.				protein catabolic process	SCF ubiquitin ligase complex	protein binding			kidney(1)|large_intestine(1)|lung(3)|ovary(1)|pancreas(1)|prostate(1)	8	Ovarian(185;0.249)	Lung NSC(185;4.15e-05)|all_lung(284;4.76e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;5.41e-06)|COAD - Colon adenocarcinoma(227;0.000255)|BRCA - Breast invasive adenocarcinoma(304;0.0003)|Kidney(185;0.000758)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(313;0.00727)|READ - Rectum adenocarcinoma(331;0.0649)		GATGCCAAGTGGAGGGAGGTG	0.657000													12	50					7.03913e-09	8.99039e-09	1	1	0
FOXP2	93986	broad.mit.edu	37	7	114302195	114302195	+	Missense_Mutation	SNP	G	G	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr7:114302195G>T	ENST00000408937.3	+	15	2172	c.1798G>T	c.(1798-1800)Gtg>Ttg	p.V600L	FOXP2_ENST00000393498.2_Missense_Mutation_p.V554L|FOXP2_ENST00000393494.2_Missense_Mutation_p.V575L|FOXP2_ENST00000393489.3_Missense_Mutation_p.V483L|FOXP2_ENST00000403559.4_Missense_Mutation_p.V592L|FOXP2_ENST00000350908.4_Missense_Mutation_p.V575L|FOXP2_ENST00000393491.3_Missense_Mutation_p.V390L|FOXP2_ENST00000393500.3_3'UTR	NM_001172766.2|NM_014491.3|NM_148898.3	NP_001166237.1|NP_055306.1|NP_683696.2	O15409	FOXP2_HUMAN	forkhead box P2	575					camera-type eye development|caudate nucleus development|cerebellum development|cerebral cortex development|embryo development|growth|lung alveolus development|negative regulation of transcription, DNA-dependent|pattern specification process|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of mesenchymal cell proliferation|post-embryonic development|putamen development|regulation of sequence-specific DNA binding transcription factor activity|righting reflex|skeletal muscle tissue development|smooth muscle tissue development|vocal learning	cytoplasm|transcription factor complex	chromatin binding|DNA bending activity|double-stranded DNA binding|promoter binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|zinc ion binding			breast(3)|endometrium(7)|kidney(4)|large_intestine(7)|lung(22)|ovary(4)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	52						AGTATGGACTGTGGATGAAGT	0.388000													7	51					0.000274275	0.000299485	1	1	0
PTPRB	5787	broad.mit.edu	37	12	70965068	70965068	+	Splice_Site	SNP	A	A	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr12:70965068A>T	ENST00000334414.6	-	13	3152	c.3106_splice	c.e13-1	p.I1036_splice	PTPRB_ENST00000551525.1_Splice_Site_p.I1035_splice|PTPRB_ENST00000451516.2_Splice_Site_p.I728_splice|PTPRB_ENST00000550857.1_Splice_Site_p.I728_splice|PTPRB_ENST00000538708.1_Splice_Site_p.I818_splice|PTPRB_ENST00000550358.1_Splice_Site_p.I948_splice|PTPRB_ENST00000261266.5_Splice_Site_p.I818_splice	NM_001109754.2	NP_001103224.1	P23467	PTPRB_HUMAN	protein tyrosine phosphatase, receptor type, B	818	Fibronectin type-III 12.				angiogenesis	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			breast(4)|central_nervous_system(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(8)|lung(46)|prostate(4)|skin(18)|upper_aerodigestive_tract(1)|urinary_tract(3)	107	Renal(347;0.236)		GBM - Glioblastoma multiforme(2;2.17e-05)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00306)|STAD - Stomach adenocarcinoma(21;0.149)			CAGGCTCTGGAACTAGGGAGA	0.428000													5	18					0	0	1	0	0
SLC35F3	148641	broad.mit.edu	37	1	234367227	234367227	+	Silent	SNP	C	C	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr1:234367227C>T	ENST00000366618.3	+	3	493	c.348C>T	c.(346-348)gcC>gcT	p.A116A	SLC35F3_ENST00000366617.3_Silent_p.A47A	NM_173508.2	NP_775779.1	Q8IY50	S35F3_HUMAN	solute carrier family 35, member F3	47					transport	integral to membrane				breast(2)|endometrium(3)|kidney(2)|large_intestine(7)|lung(13)|ovary(2)|skin(2)|urinary_tract(1)	32	Ovarian(103;0.0454)	all_cancers(173;0.145)|Prostate(94;0.0885)	OV - Ovarian serous cystadenocarcinoma(106;0.00531)			GGGTGGAGGCCGGCGGGAGAG	0.741000													7	74					0	0	1	0	0
TIMD4	91937	broad.mit.edu	37	5	156349143	156349143	+	Missense_Mutation	SNP	G	G	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr5:156349143G>T	ENST00000274532.2	-	7	1035	c.979C>A	c.(979-981)Ctc>Atc	p.L327I	TIMD4_ENST00000406964.1_Missense_Mutation_p.L29I|TIMD4_ENST00000407087.3_Missense_Mutation_p.L299I	NM_138379.2	NP_612388.2	Q96H15	TIMD4_HUMAN	T-cell immunoglobulin and mucin domain containing 4	327						integral to membrane				NS(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(23)|ovary(2)|skin(2)	37	Renal(175;0.00488)	Medulloblastoma(196;0.0523)|all_neural(177;0.21)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			AATGCGAAGAGCACAAATCCC	0.527000													11	21					4.68919e-08	5.86e-08	1	1	0
CNTN3	5067	broad.mit.edu	37	3	74411128	74411128	+	Missense_Mutation	SNP	A	A	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr3:74411128A>T	ENST00000263665.6	-	10	1304	c.1277T>A	c.(1276-1278)cTg>cAg	p.L426Q		NM_020872.1	NP_065923.1	Q9P232	CNTN3_HUMAN	contactin 3 (plasmacytoma associated)	426	Ig-like C2-type 5.				cell adhesion	anchored to membrane|plasma membrane	protein binding			NS(2)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(39)|ovary(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	83		Lung NSC(201;0.138)|Lung SC(41;0.21)		Epithelial(33;0.00212)|BRCA - Breast invasive adenocarcinoma(55;0.00258)|LUSC - Lung squamous cell carcinoma(21;0.00461)|Lung(16;0.01)		CAAGCTGACCAGGCTGCCCAC	0.498000													13	63					0	0	1	0	0
BUB1	699	broad.mit.edu	37	2	111408179	111408179	+	Missense_Mutation	SNP	G	G	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr2:111408179G>A	ENST00000535254.1	-	17	2154	c.2087C>T	c.(2086-2088)gCt>gTt	p.A696V	BUB1_ENST00000409311.1_Missense_Mutation_p.A716V|BUB1_ENST00000302759.6_Missense_Mutation_p.A716V	NM_001278616.1	NP_001265545.1	O43683	BUB1_HUMAN	BUB1 mitotic checkpoint serine/threonine kinase	716					apoptosis|cell division|chromosome segregation|interspecies interaction between organisms|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|regulation of sister chromatid cohesion	condensed chromosome kinetochore|cytosol	ATP binding|protein binding|protein serine/threonine kinase activity			breast(3)|endometrium(8)|kidney(4)|large_intestine(9)|lung(18)|ovary(1)|prostate(1)|stomach(1)	45		Ovarian(717;0.0822)		BRCA - Breast invasive adenocarcinoma(221;0.0556)		TTGGAGCCCAGCAATAGCATC	0.517000													15	40					0	0	1	0	0
SIGLEC16	400709	broad.mit.edu	37	19	50474938	50474938	+	RNA	SNP	C	C	G	rs138936320	by1000genomes	TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr19:50474938C>G	ENST00000602139.1	+	0	1013									sialic acid binding Ig-like lectin 16 (gene/pseudogene)											endometrium(2)|kidney(2)|lung(6)	10						TCCAGAGAACCTGAGAGTGAT	0.592000													7	92					0	0	1	0	0
RBM39	9584	broad.mit.edu	37	20	34302144	34302144	+	Silent	SNP	T	T	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr20:34302144T>A	ENST00000361162.6	-	11	1443	c.1059A>T	c.(1057-1059)acA>acT	p.T353T	RBM39_ENST00000407261.4_Silent_p.T196T|RBM39_ENST00000253363.6_Silent_p.T353T|RBM39_ENST00000528062.3_Silent_p.T331T	NM_004902.3|NM_184234.2	NP_004893.1|NP_909122.1	Q14498	RBM39_HUMAN	RNA binding motif protein 39	353	Activating domain (By similarity).|Interaction with JUN (By similarity).				mRNA processing|regulation of transcription, DNA-dependent|RNA splicing|transcription, DNA-dependent	centrosome|nuclear speck	nucleotide binding|protein binding|RNA binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(6)|lung(6)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	35	all_epithelial(2;0.00295)|Lung NSC(9;0.00453)|Breast(12;0.00544)|all_lung(11;0.00676)					GACGACCAGTTGTTCCCAAAT	0.408000													10	93					0	0	1	0	0
ZFC3H1	196441	broad.mit.edu	37	12	72017265	72017265	+	Missense_Mutation	SNP	G	G	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr12:72017265G>A	ENST00000378743.3	-	24	4977	c.4619C>T	c.(4618-4620)tCa>tTa	p.S1540L		NM_144982.4	NP_659419.3	O60293	ZC3H1_HUMAN	zinc finger, C3H1-type containing	1540					RNA processing	intracellular	metal ion binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(4)|large_intestine(12)|lung(31)|ovary(3)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	69						ATAAAATTTTGAAGGGAGAAT	0.348000													9	85					0	0	1	0	0
ESRP1	54845	broad.mit.edu	37	8	95683825	95683825	+	Missense_Mutation	SNP	G	G	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr8:95683825G>A	ENST00000433389.2	+	11	1568	c.1378G>A	c.(1378-1380)Gac>Aac	p.D460N	ESRP1_ENST00000358397.5_Missense_Mutation_p.D460N|ESRP1_ENST00000423620.2_Missense_Mutation_p.D460N|ESRP1_ENST00000454170.2_Missense_Mutation_p.D460N	NM_001034915.2|NM_017697.3	NP_001030087.2|NP_060167.2	Q6NXG1	ESRP1_HUMAN	epithelial splicing regulatory protein 1	460	RRM 3.				mRNA processing|regulation of RNA splicing|RNA splicing	nucleus|plasma membrane	mRNA binding|nucleotide binding		ESRP1/RAF1(4)	NS(1)|central_nervous_system(1)|endometrium(6)|kidney(1)|large_intestine(2)|lung(6)|prostate(1)|urinary_tract(2)	20						CACAATTGAGGACATCCTGGA	0.463000													7	39					0	0	1	0	0
GEMIN7	79760	broad.mit.edu	37	19	45593559	45593559	+	Missense_Mutation	SNP	C	C	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr19:45593559C>T	ENST00000270257.4	+	3	434	c.187C>T	c.(187-189)Cgg>Tgg	p.R63W	GEMIN7_ENST00000591747.1_Missense_Mutation_p.R63W|CTB-179K24.3_ENST00000586556.1_RNA|CTB-179K24.4_ENST00000586744.1_RNA|GEMIN7_ENST00000391951.2_Missense_Mutation_p.R63W|GEMIN7_ENST00000591607.1_Missense_Mutation_p.R63W	NM_001007269.1|NM_001007270.1|NM_024707.2	NP_001007270.1|NP_001007271.1|NP_078983.1	Q9H840	GEMI7_HUMAN	gem (nuclear organelle) associated protein 7	63					ncRNA metabolic process|spliceosomal snRNP assembly	Cajal body|cytosol|spliceosomal complex	protein binding			endometrium(1)|kidney(1)|lung(4)|ovary(1)	7		Ovarian(192;0.0728)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.0131)		AGCCGCCCTTCGGGAGCGTTA	0.632000													12	67					0	0	1	0	0
TRIM3	10612	broad.mit.edu	37	11	6477718	6477718	+	Missense_Mutation	SNP	G	G	C			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr11:6477718G>C	ENST00000525074.1	-	6	1632	c.1238C>G	c.(1237-1239)cCc>cGc	p.P413R	TRIM3_ENST00000359518.3_Missense_Mutation_p.P413R|TRIM3_ENST00000529058.1_Intron|TRIM3_ENST00000345851.3_Missense_Mutation_p.P413R|TRIM3_ENST00000537602.1_Missense_Mutation_p.P335R|TRIM3_ENST00000536344.1_Missense_Mutation_p.P294R	NM_001248006.1	NP_001234935.1	O75382	TRIM3_HUMAN	tripartite motif containing 3	413					nervous system development|protein transport	early endosome	protein C-terminus binding|zinc ion binding			breast(1)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(8)|ovary(1)|prostate(2)|skin(3)	27		all_lung(207;9.97e-06)|Lung NSC(207;1.74e-05)|Medulloblastoma(188;0.00225)|Breast(177;0.0204)|all_neural(188;0.0212)		Epithelial(150;9.34e-10)|Lung(200;0.0234)|LUSC - Lung squamous cell carcinoma(625;0.133)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CACGCGGAAGGGGCTGCCGCG	0.677000													5	30					0	0	1	0	0
CCDC13	152206	broad.mit.edu	37	3	42750505	42750505	+	Silent	SNP	C	C	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr3:42750505C>T	ENST00000310232.6	-	16	2198	c.2115G>A	c.(2113-2115)caG>caA	p.Q705Q		NM_144719.3	NP_653320.3	Q8IYE1	CCD13_HUMAN	coiled-coil domain containing 13	705										endometrium(1)|kidney(1)|large_intestine(5)|liver(1)|lung(11)|ovary(1)|prostate(3)|skin(1)|urinary_tract(1)	25						GCCGCAGGGCCTGCAGGAAGA	0.592000													20	111					0	0	1	0	0
CTSC	1075	broad.mit.edu	37	11	88042330	88042330	+	Splice_Site	SNP	C	C	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr11:88042330C>A	ENST00000227266.5	-	4	756		c.e4+1			NM_001814.4	NP_001805.3	P53634	CATC_HUMAN	cathepsin C						immune response	lysosome	cysteine-type endopeptidase activity			large_intestine(7)|lung(8)|ovary(2)|prostate(3)|skin(2)	22		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)				TGCTTGATTACCTTGGGATTT	0.408000													6	45					0.0215528	0.0220675	1	1	0
COL1A1	1277	broad.mit.edu	37	17	48270371	48270371	+	Missense_Mutation	SNP	C	C	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr17:48270371C>A	ENST00000225964.5	-	26	1923	c.1805G>T	c.(1804-1806)gGa>gTa	p.G602V		NM_000088.3	NP_000079.2	P02452	CO1A1_HUMAN	collagen, type I, alpha 1	602	Triple-helical region.		G -> R (in OI2A).		axon guidance|blood vessel development|collagen biosynthetic process|collagen fibril organization|embryonic skeletal system development|leukocyte migration|platelet activation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell migration|positive regulation of epithelial to mesenchymal transition|positive regulation of transcription, DNA-dependent|protein localization to nucleus|sensory perception of sound|skin morphogenesis|tooth mineralization|visual perception	collagen type I|extracellular space|plasma membrane	identical protein binding|platelet-derived growth factor binding		COL1A1/PDGFB(429)	NS(1)|breast(3)|central_nervous_system(8)|endometrium(3)|kidney(4)|large_intestine(17)|liver(3)|lung(18)|ovary(1)|pancreas(1)|prostate(4)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	71					Collagenase(DB00048)|Palifermin(DB00039)	GCCAGGGGGTCCGGGAACACC	0.632000			T	"""PDGFB, USP6"""	"""dermatofibrosarcoma protuberans, aneurysmal bone cyst """		Osteogenesis imperfecta						6	34					0.00307968	0.00324766	1	1	0
EMR1	2015	broad.mit.edu	37	19	6901981	6901981	+	Missense_Mutation	SNP	G	G	C			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr19:6901981G>C	ENST00000312053.4	+	6	647	c.610G>C	c.(610-612)Gaa>Caa	p.E204Q	EMR1_ENST00000450315.3_Intron|EMR1_ENST00000381407.5_Intron|EMR1_ENST00000381404.4_Missense_Mutation_p.E152Q|EMR1_ENST00000250572.8_Missense_Mutation_p.E204Q	NM_001974.4	NP_001965.3	Q14246	EMR1_HUMAN	egf-like module containing, mucin-like, hormone receptor-like 1	204	EGF-like 4; calcium-binding (Potential).				cell adhesion|neuropeptide signaling pathway	integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity	p.E204K(1)		NS(2)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(11)|lung(31)|ovary(3)|prostate(1)|skin(8)	62	all_hematologic(4;0.166)					CCCAGGATTTGAATCCAGCAG	0.473000													47	169					0	0	1	0	0
PYDC1	260434	broad.mit.edu	37	16	31228130	31228130	+	Missense_Mutation	SNP	G	G	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr16:31228130G>A	ENST00000302964.3	-	1	550	c.220C>T	c.(220-222)Cgc>Tgc	p.R74C	TRIM72_ENST00000322122.3_Intron	NM_152901.2	NP_690865.1	Q8WXC3	PYDC1_HUMAN	PYD (pyrin domain) containing 1	74	DAPIN.				innate immune response|negative regulation of NF-kappaB transcription factor activity|negative regulation of protein kinase activity|positive regulation of interleukin-1 beta secretion|proteolysis|tumor necrosis factor-mediated signaling pathway	IkappaB kinase complex|nucleus	cysteine-type endopeptidase activity|protein binding	p.R74C(1)		endometrium(1)|kidney(1)|large_intestine(2)|lung(1)	5						CGCATGTCGCGCAGCACGGCC	0.677000													19	49					0	0	1	0	0
MFSD2A	84879	broad.mit.edu	37	1	40432481	40432481	+	Splice_Site	SNP	A	A	G			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr1:40432481A>G	ENST00000372809.5	+	8	987		c.e8-1		MFSD2A_ENST00000372811.5_Splice_Site|MFSD2A_ENST00000480630.1_Intron|MFSD2A_ENST00000420632.2_Splice_Site	NM_001136493.1	NP_001129965.1	Q8NA29	MFS2A_HUMAN	major facilitator superfamily domain containing 2A						transmembrane transport	endoplasmic reticulum membrane|integral to membrane				breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(3)|lung(6)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	24						TCTGGCCCCCAGAACCCTATG	0.592000													17	170					0	0	1	0	0
ZNF366	167465	broad.mit.edu	37	5	71739768	71739768	+	Missense_Mutation	SNP	C	C	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr5:71739768C>A	ENST00000318442.5	-	5	2540	c.2050G>T	c.(2050-2052)Ggg>Tgg	p.G684W		NM_152625.1	NP_689838.1	Q8N895	ZN366_HUMAN	zinc finger protein 366	684					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(9)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	35		Lung NSC(167;0.0247)|Ovarian(174;0.0908)|Prostate(461;0.155)		OV - Ovarian serous cystadenocarcinoma(47;2.51e-53)		CCCTCTGCCCCAAGGTCACCC	0.602000													36	170					4.3181e-19	6.3547e-19	1	1	0
OR4K14	122740	broad.mit.edu	37	14	20482726	20482726	+	Missense_Mutation	SNP	C	C	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr14:20482726C>A	ENST00000305045.2	-	1	626	c.627G>T	c.(625-627)ttG>ttT	p.L209F		NM_001004712.1	NP_001004712.1	Q8NGD5	OR4KE_HUMAN	olfactory receptor, family 4, subfamily K, member 14	209					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(3)|endometrium(3)|kidney(1)|large_intestine(4)|lung(20)|skin(6)	37	all_cancers(95;0.00108)		Epithelial(56;4.65e-07)|all cancers(55;2e-06)	GBM - Glioblastoma multiforme(265;0.00124)		GAAAACAGCTCAAGGAAAGCA	0.507000													20	52					3.99206e-14	5.5991e-14	1	1	0
VSTM2A	222008	broad.mit.edu	37	7	54617721	54617721	+	Silent	SNP	C	C	G			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr7:54617721C>G	ENST00000302287.3	+	4	898	c.492C>G	c.(490-492)ccC>ccG	p.P164P	VSTM2A_ENST00000407838.3_Silent_p.P164P|VSTM2A_ENST00000498834.1_3'UTR|VSTM2A_ENST00000402026.2_Silent_p.P163P|VSTM2A_ENST00000402613.3_Silent_p.P164P|VSTM2A_ENST00000404951.1_Silent_p.P164P			Q8TAG5	VTM2A_HUMAN	V-set and transmembrane domain containing 2A	164						extracellular region				endometrium(1)|large_intestine(2)|lung(12)|prostate(1)	16			STAD - Stomach adenocarcinoma(5;0.0525)			AAGCCTCGCCCATGTGGCTGC	0.597000													4	24					0	0	1	0	0
HCN1	348980	broad.mit.edu	37	5	45645307	45645307	+	Missense_Mutation	SNP	A	A	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr5:45645307A>T	ENST00000303230.4	-	2	886	c.829T>A	c.(829-831)Tac>Aac	p.Y277N		NM_021072.3	NP_066550.2	O60741	HCN1_HUMAN	hyperpolarization activated cyclic nucleotide-gated potassium channel 1	277						integral to membrane	cAMP binding|sodium channel activity|voltage-gated potassium channel activity			NS(3)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(21)|liver(1)|lung(98)|ovary(1)|prostate(7)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(5)	156						TGATGTATGTATCTAATTAAC	0.338000													7	48					0	0	1	0	0
EPHA10	284656	broad.mit.edu	37	1	38184332	38184332	+	Splice_Site	SNP	C	C	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr1:38184332C>A	ENST00000373048.4	-	16	2912		c.e16+1		EPHA10_ENST00000540011.1_Splice_Site|EPHA10_ENST00000427468.2_Splice_Site|EPHA10_ENST00000330210.7_Splice_Site|EPHA10_ENST00000446149.2_Splice_Site	NM_001099439.1	NP_001092909.1	Q5JZY3	EPHAA_HUMAN	EPH receptor A10							extracellular region|integral to membrane|integral to plasma membrane	ATP binding|ephrin receptor activity|protein binding|transmembrane-ephrin receptor activity			NS(2)|breast(4)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(4)|lung(13)|prostate(3)|skin(8)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	50	Acute lymphoblastic leukemia(166;0.074)|all_hematologic(146;0.197)	Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				CTTGGACTCACTGGGCAGTCA	0.672000													18	46					5.3912e-06	6.2538e-06	1	1	0
USP9Y	8287	broad.mit.edu	37	Y	14851540	14851540	+	Missense_Mutation	SNP	G	G	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chrY:14851540G>T	ENST00000338981.3	+	12	2344	c.1399G>T	c.(1399-1401)Gat>Tat	p.D467Y	USP9Y_ENST00000426564.2_3'UTR	NM_004654.3	NP_004645.2	O00507	USP9Y_HUMAN	ubiquitin specific peptidase 9, Y-linked	467					BMP signaling pathway|protein deubiquitination|spermatogenesis|transforming growth factor beta receptor signaling pathway|ubiquitin-dependent protein catabolic process	cytoplasm	co-SMAD binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			kidney(1)|large_intestine(8)|lung(5)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	17						TGGACAACTTGATCATCTTTT	0.333000													14	21					6.31663e-08	7.82436e-08	1	1	0
PFKFB3	5209	broad.mit.edu	37	10	6263607	6263607	+	Missense_Mutation	SNP	G	G	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr10:6263607G>T	ENST00000379775.4	+	10	1312	c.982G>T	c.(982-984)Gtc>Ttc	p.V328F	PFKFB3_ENST00000540253.1_Missense_Mutation_p.V342F|PFKFB3_ENST00000536985.1_Intron|PFKFB3_ENST00000379789.4_Missense_Mutation_p.V308F|PFKFB3_ENST00000379785.1_Missense_Mutation_p.V328F|PFKFB3_ENST00000360521.2_Missense_Mutation_p.V328F|PFKFB3_ENST00000317350.4_Missense_Mutation_p.V328F|PFKFB3_ENST00000379782.3_Missense_Mutation_p.V328F	NM_004566.3	NP_004557.1	Q16875	F263_HUMAN	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3	328	Fructose-2,6-bisphosphatase.				fructose 2,6-bisphosphate metabolic process|glycolysis	cytosol	6-phosphofructo-2-kinase activity|ATP binding|fructose-2,6-bisphosphate 2-phosphatase activity|identical protein binding			central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(1)|liver(2)|lung(10)|ovary(3)|upper_aerodigestive_tract(1)	22						CCCGCAGGGCGTCTGTGAGGA	0.642000													3	12					0.004672	0.00490585	1	1	0
LCN1	3933	broad.mit.edu	37	9	138415126	138415126	+	Missense_Mutation	SNP	C	C	G			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr9:138415126C>G	ENST00000263598.2	+	3	330	c.270C>G	c.(268-270)gaC>gaG	p.D90E	LCN1_ENST00000371781.3_Missense_Mutation_p.D90E	NM_001252617.1|NM_001252618.1|NM_001252619.1|NM_002297.3	NP_001239546.1|NP_001239547.1|NP_001239548.1|NP_002288.1	P31025	LCN1_HUMAN	lipocalin 1	90					proteolysis|response to stimulus|sensory perception of taste	extracellular region	cysteine-type endopeptidase inhibitor activity|transporter activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(5)	13		Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;1.54e-08)|Epithelial(140;5.25e-08)|all cancers(34;9.27e-07)|READ - Rectum adenocarcinoma(205;0.155)		AGAAAACTGACGAGCCGGGAA	0.647000													4	21					0	0	1	0	0
SALL1	6299	broad.mit.edu	37	16	51174565	51174565	+	Missense_Mutation	SNP	C	C	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr16:51174565C>T	ENST00000440970.1	-	2	1708	c.1277G>A	c.(1276-1278)aGt>aAt	p.S426N	SALL1_ENST00000541611.1_Intron|SALL1_ENST00000251020.4_Missense_Mutation_p.S523N|SALL1_ENST00000566102.1_Intron	NM_001127892.1	NP_001121364.1	Q9NSC2	SALL1_HUMAN	spalt-like transcription factor 1	523					adrenal gland development|branching involved in ureteric bud morphogenesis|embryonic digestive tract development|embryonic digit morphogenesis|gonad development|histone deacetylation|inductive cell-cell signaling|mesenchymal to epithelial transition involved in metanephros morphogenesis|negative regulation of transcription from RNA polymerase II promoter|olfactory bulb interneuron differentiation|olfactory bulb mitral cell layer development|olfactory nerve development|outer ear morphogenesis|pituitary gland development|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway|ureteric bud invasion|ventricular septum development	chromocenter|cytoplasm|heterochromatin|nucleus	beta-catenin binding|DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(4)|breast(2)|central_nervous_system(2)|endometrium(3)|kidney(5)|large_intestine(25)|lung(61)|ovary(3)|prostate(6)|skin(12)|upper_aerodigestive_tract(3)	126		all_cancers(37;0.0322)	COAD - Colon adenocarcinoma(2;0.24)			GATGCCAGTACTCGTGGGGAT	0.522000													12	96					0	0	1	0	0
SIM1	6492	broad.mit.edu	37	6	100897278	100897278	+	Missense_Mutation	SNP	C	C	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr6:100897278C>A	ENST00000369208.3	-	6	1286	c.504G>T	c.(502-504)ttG>ttT	p.L168F	SIM1_ENST00000262901.4_Missense_Mutation_p.L168F			P81133	SIM1_HUMAN	single-minded family bHLH transcription factor 1	168					cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			breast(1)|central_nervous_system(4)|endometrium(5)|kidney(1)|large_intestine(15)|lung(34)|ovary(4)|prostate(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(5)	79		all_cancers(76;9.88e-06)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(107;0.0248)|Colorectal(196;0.13)		BRCA - Breast invasive adenocarcinoma(108;0.0774)		TACGCTTGGCCAAGACGCACT	0.627000													5	35					0.00116845	0.00124685	1	1	0
IGF1R	3480	broad.mit.edu	37	15	99251008	99251008	+	Silent	SNP	G	G	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr15:99251008G>T	ENST00000268035.6	+	2	923	c.312G>T	c.(310-312)acG>acT	p.T104T	IGF1R_ENST00000558762.1_Silent_p.T104T	NM_000875.3	NP_000866.1	P08069	IGF1R_HUMAN	insulin-like growth factor 1 receptor	104					anti-apoptosis|immune response|insulin receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of cell migration|positive regulation of cell proliferation|positive regulation of DNA replication|protein autophosphorylation|protein tetramerization	microsome	ATP binding|identical protein binding|insulin binding|insulin receptor binding|insulin receptor substrate binding|insulin-like growth factor I binding|insulin-like growth factor receptor activity|metal ion binding|phosphatidylinositol 3-kinase binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(13)|lung(20)|ovary(1)|prostate(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	63	all_cancers(4;4.17e-14)|all_epithelial(3;4.34e-15)|Lung NSC(78;0.00175)|all_lung(78;0.00351)|Melanoma(26;0.00505)|Medulloblastoma(229;0.163)		Epithelial(2;1.94e-12)|all cancers(5;6.83e-11)|BRCA - Breast invasive adenocarcinoma(2;2.88e-09)|OV - Ovarian serous cystadenocarcinoma(32;0.00261)		Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Mecasermin(DB01277)	CCAACCTCACGGTCATCCGCG	0.547000													9	43					3.09899e-07	3.74461e-07	1	1	0
ATP4A	495	broad.mit.edu	37	19	36053346	36053346	+	Silent	SNP	G	G	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr19:36053346G>T	ENST00000262623.3	-	4	439	c.411C>A	c.(409-411)acC>acA	p.T137T		NM_000704.2	NP_000695.2	P20648	ATP4A_HUMAN	ATPase, H+/K+ exchanging, alpha polypeptide	137					ATP biosynthetic process|ATP hydrolysis coupled proton transport	integral to plasma membrane	ATP binding|hydrogen:potassium-exchanging ATPase activity|magnesium ion binding			breast(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(26)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)	53	all_lung(56;1.05e-07)|Lung NSC(56;1.63e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0724)		Esomeprazole(DB00736)|Lansoprazole(DB00448)|Omeprazole(DB00338)|Pantoprazole(DB00213)|Rabeprazole(DB01129)|Trifluoperazine(DB00831)	CATTGTCGTCGGTGGTGAGGT	0.637000													13	30					1.5842e-08	2.01032e-08	1	1	0
HAUS1	115106	broad.mit.edu	37	18	43708088	43708088	+	Silent	SNP	G	G	C			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr18:43708088G>C	ENST00000282058.6	+	9	914	c.834G>C	c.(832-834)ctG>ctC	p.L278L	HAUS1_ENST00000588704.1_3'UTR|HAUS1_ENST00000585518.1_3'UTR	NM_138443.3	NP_612452.1	Q96CS2	HAUS1_HUMAN	HAUS augmin-like complex, subunit 1	278					cell division|centrosome organization|mitosis|spindle assembly	centrosome|HAUS complex|microtubule|spindle pole				endometrium(1)|kidney(1)|large_intestine(2)|lung(2)|ovary(1)	7						TGATGGAACTGTGACAAAAGC	0.343000													9	26					0	0	1	0	0
KRTAP1-5	83895	broad.mit.edu	37	17	39183145	39183145	+	Missense_Mutation	SNP	A	A	G			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr17:39183145A>G	ENST00000361883.5	-	1	309	c.263T>C	c.(262-264)aTc>aCc	p.I88T		NM_031957.1	NP_114163.1	Q9BYS1	KRA15_HUMAN	keratin associated protein 1-5	88	15 X 5 AA repeats of C-C-[QEPVRC]- [TPIVLE]-[SRHVP].					keratin filament		p.I88T(11)		central_nervous_system(1)|endometrium(2)|kidney(1)|lung(9)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(2)	17		Breast(137;0.00043)	STAD - Stomach adenocarcinoma(17;0.000371)			GCAGGAGCTGATCTGGCAGCA	0.632000													6	89					0	0	1	0	0
SMC3	9126	broad.mit.edu	37	10	112362320	112362320	+	Missense_Mutation	SNP	G	G	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr10:112362320G>T	ENST00000361804.4	+	26	3320	c.3194G>T	c.(3193-3195)aGt>aTt	p.S1065I		NM_005445.3	NP_005436.1	Q9UQE7	SMC3_HUMAN	structural maintenance of chromosomes 3	1065					cell division|DNA mediated transformation|DNA repair|meiosis|mitotic metaphase/anaphase transition|mitotic prometaphase|mitotic spindle organization|negative regulation of DNA endoreduplication|signal transduction|sister chromatid cohesion	basement membrane|chromatin|chromosome, centromeric region|cytoplasm|meiotic cohesin complex|nuclear matrix|nucleoplasm|spindle pole	ATP binding|dynein binding|microtubule motor activity|protein heterodimerization activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|large_intestine(5)|lung(13)|ovary(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	39		Breast(234;0.0848)|Lung NSC(174;0.238)		Epithelial(162;0.00206)|all cancers(201;0.0227)|BRCA - Breast invasive adenocarcinoma(275;0.127)		GTGGAGGGCAGTCAGTCTCAA	0.448000													7	39					0.00307968	0.00324766	1	1	0
TAS2R42	353164	broad.mit.edu	37	12	11339199	11339199	+	Silent	SNP	G	G	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr12:11339199G>T	ENST00000334266.1	-	1	344	c.345C>A	c.(343-345)ccC>ccA	p.P115P		NM_181429.1	NP_852094.1	Q7RTR8	T2R42_HUMAN	taste receptor, type 2, member 42	115					sensory perception of taste	integral to membrane	G-protein coupled receptor activity			breast(1)|kidney(2)|lung(4)|ovary(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	11			OV - Ovarian serous cystadenocarcinoma(49;0.0455)			AAAGGGAGTGGGGGAAGTGGG	0.408000													14	39					1.49906e-05	1.70875e-05	1	1	0
STAG1	10274	broad.mit.edu	37	3	136141254	136141254	+	Missense_Mutation	SNP	C	C	G			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr3:136141254C>G	ENST00000383202.2	-	19	2291	c.2035G>C	c.(2035-2037)Gag>Cag	p.E679Q	STAG1_ENST00000536929.1_Missense_Mutation_p.E263Q|STAG1_ENST00000434713.2_Missense_Mutation_p.E453Q|STAG1_ENST00000236698.5_Missense_Mutation_p.E679Q	NM_005862.2	NP_005853.2	Q8WVM7	STAG1_HUMAN	stromal antigen 1	679					cell division|chromosome segregation|mitotic metaphase/anaphase transition|mitotic prometaphase	cell junction|chromatin|chromosome, centromeric region|nucleoplasm	protein binding			NS(2)|breast(4)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(16)|lung(16)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	58						GAACAGACCTCTTGCAATAGG	0.328000													11	61					0	0	1	0	0
GRM6	2916	broad.mit.edu	37	5	178413499	178413499	+	Missense_Mutation	SNP	C	C	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr5:178413499C>T	ENST00000231188.5	-	8	1934	c.1756G>A	c.(1756-1758)Gca>Aca	p.A586T	GRM6_ENST00000517717.1_Missense_Mutation_p.A586T|RP11-281O15.4_ENST00000519491.1_RNA	NM_000843.3	NP_000834.2	O15303	GRM6_HUMAN	glutamate receptor, metabotropic 6	586					detection of visible light|visual perception	integral to plasma membrane				NS(2)|breast(4)|endometrium(9)|large_intestine(12)|lung(21)|ovary(2)|pancreas(1)|prostate(3)|urinary_tract(1)	55	all_cancers(89;0.000828)|Renal(175;0.000159)|all_epithelial(37;0.000167)|Lung NSC(126;0.00199)|all_lung(126;0.00351)	all_cancers(40;0.0156)|all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.245)		GGCGGGGCTGCCCAGGGGGAG	0.701000													6	30					0	0	1	0	0
SLCO1B1	10599	broad.mit.edu	37	12	21327635	21327635	+	Missense_Mutation	SNP	C	C	G			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr12:21327635C>G	ENST00000256958.2	+	4	447	c.351C>G	c.(349-351)ttC>ttG	p.F117L		NM_006446.4	NP_006437.3	Q9Y6L6	SO1B1_HUMAN	solute carrier organic anion transporter family, member 1B1	117					bile acid metabolic process|sodium-independent organic anion transport	basolateral plasma membrane|integral to plasma membrane|membrane fraction	bile acid transmembrane transporter activity|sodium-independent organic anion transmembrane transporter activity|thyroid hormone transmembrane transporter activity	p.F117F(1)		breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(14)|lung(33)|ovary(3)|pancreas(1)|prostate(1)|skin(8)|upper_aerodigestive_tract(1)	70					Digoxin(DB00390)|Gemfibrozil(DB01241)|Pravastatin(DB00175)	CACATTTCTTCATGGGATAGT	0.338000													12	20					0	0	1	0	0
NCAPD3	23310	broad.mit.edu	37	11	134073619	134073619	+	Silent	SNP	G	G	C			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr11:134073619G>C	ENST00000534548.2	-	11	1462	c.1398C>G	c.(1396-1398)tcC>tcG	p.S466S		NM_015261.2	NP_056076.1	P42695	CNDD3_HUMAN	non-SMC condensin II complex, subunit D3	466					cell division|mitotic chromosome condensation	nuclear centromeric heterochromatin|nuclear condensin complex	methylated histone residue binding			NS(1)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(10)|kidney(5)|large_intestine(9)|liver(1)|lung(28)|ovary(3)|prostate(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	71	all_hematologic(175;0.127)	all_cancers(12;1.68e-21)|all_epithelial(12;5.86e-16)|all_lung(97;1.19e-05)|Lung NSC(97;2.76e-05)|Breast(109;0.000182)|Medulloblastoma(222;0.0245)|all_neural(223;0.0505)|Esophageal squamous(93;0.0559)		Epithelial(10;8.74e-10)|BRCA - Breast invasive adenocarcinoma(10;1e-08)|all cancers(11;1.46e-08)|OV - Ovarian serous cystadenocarcinoma(99;0.00345)|Lung(977;0.227)		GTGCAAAGCTGGACAGTGCCT	0.483000													8	67					0	0	1	0	0
ARHGEF11	9826	broad.mit.edu	37	1	156910149	156910149	+	Missense_Mutation	SNP	T	T	C			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr1:156910149T>C	ENST00000368194.3	-	36	4622	c.3583A>G	c.(3583-3585)Agt>Ggt	p.S1195G	ARHGEF11_ENST00000315174.8_Missense_Mutation_p.S571G|ARHGEF11_ENST00000487682.1_5'UTR|ARHGEF11_ENST00000361409.2_Missense_Mutation_p.S1155G	NM_198236.2	NP_937879.1	O15085	ARHGB_HUMAN	Rho guanine nucleotide exchange factor (GEF) 11	1155					actin cytoskeleton organization|apoptosis|axon guidance|cellular component movement|cytokinesis|establishment of cell polarity|G-protein coupled receptor protein signaling pathway|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|positive regulation of transcription, DNA-dependent|regulation of cell growth|regulation of Rho protein signal transduction|Rho protein signal transduction|striated muscle contraction	cytosol|Golgi apparatus|plasma membrane	G-protein-coupled receptor binding|GTPase activator activity|Rho guanyl-nucleotide exchange factor activity|signal transducer activity			NS(1)|breast(3)|central_nervous_system(3)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(15)|lung(27)|ovary(4)|pancreas(2)|pleura(1)|prostate(4)|skin(7)|stomach(1)|urinary_tract(2)	81	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					TCCTCTGCACTGCCCTCCTGC	0.587000													10	64					0	0	1	0	0
MAGI2	9863	broad.mit.edu	37	7	78256541	78256541	+	Missense_Mutation	SNP	G	G	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr7:78256541G>A	ENST00000354212.4	-	3	686	c.433C>T	c.(433-435)Cat>Tat	p.H145Y	MAGI2_ENST00000536571.1_5'UTR|MAGI2_ENST00000419488.1_Missense_Mutation_p.H145Y|MAGI2_ENST00000522391.1_Missense_Mutation_p.H145Y|MAGI2_ENST00000535697.1_5'UTR	NM_012301.3	NP_036433.2	Q86UL8	MAGI2_HUMAN	membrane associated guanylate kinase, WW and PDZ domain containing 2	145	Guanylate kinase-like.					cell junction|synapse|synaptosome	phosphatase binding			NS(1)|breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(12)|lung(37)|ovary(5)|prostate(1)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(3)	84		all_cancers(73;0.0064)|all_epithelial(88;0.087)|all_neural(109;0.0936)|Medulloblastoma(109;0.166)|Melanoma(862;0.236)				CCCTCCTTATGTGGCCTTGTG	0.378000													6	39					0	0	1	0	0
COL7A1	1294	broad.mit.edu	37	3	48602914	48602914	+	Missense_Mutation	SNP	T	T	C			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr3:48602914T>C	ENST00000328333.8	-	115	8563	c.8456A>G	c.(8455-8457)tAt>tGt	p.Y2819C	COL7A1_ENST00000454817.1_Missense_Mutation_p.Y2787C	NM_000094.3	NP_000085.1	Q02388	CO7A1_HUMAN	collagen, type VII, alpha 1	2819	Nonhelical region (NC2).				cell adhesion|epidermis development	basement membrane|collagen type VII	protein binding|serine-type endopeptidase inhibitor activity			NS(3)|breast(8)|central_nervous_system(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|lung(57)|ovary(7)|prostate(5)|skin(9)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(5)	137				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		GTCTGCAGCATAACTAGGGAG	0.642000													8	20					0	0	1	0	0
ZNF765	91661	broad.mit.edu	37	19	53911497	53911497	+	Nonsense_Mutation	SNP	T	T	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr19:53911497T>A	ENST00000396408.3	+	4	806	c.689T>A	c.(688-690)tTa>tAa	p.L230*	ZNF765_ENST00000594030.1_Intron	NM_001040185.1	NP_001035275.1	Q7L2R6	ZN765_HUMAN	zinc finger protein 765	230					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|lung(3)	4				GBM - Glioblastoma multiforme(134;0.00379)		AGCTCACTCTTAAGGAAACAT	0.368000													27	46					0	0	1	0	0
HSP90AB2P	391634	broad.mit.edu	37	4	13338250	13338250	+	RNA	SNP	G	G	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr4:13338250G>A	ENST00000602906.1	+	0	268																				kidney(3)|lung(1)	4						TAATGCTTCTGATGCCTTGGA	0.423000													11	50					0	0	1	0	0
TFAP2C	7022	broad.mit.edu	37	20	55209267	55209267	+	Missense_Mutation	SNP	C	C	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr20:55209267C>A	ENST00000201031.2	+	5	1108	c.865C>A	c.(865-867)Ctt>Att	p.L289I	TFAP2C_ENST00000544508.1_Missense_Mutation_p.L120I	NM_003222.3	NP_003213.1	Q92754	AP2C_HUMAN	transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)	289					cell-cell signaling|male gonad development|regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|protein dimerization activity|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	13			Colorectal(105;0.229)			TGGGTTGAATCTTCCGGCCGG	0.453000													15	102					3.27435e-08	4.10752e-08	1	1	0
CFAP221	200373	broad.mit.edu	37	2	120383232	120383232	+	Missense_Mutation	SNP	A	A	C			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr2:120383232A>C	ENST00000602047.1	+	16	1738	c.626A>C	c.(625-627)aAg>aCg	p.K209T	PCDP1_ENST00000597189.1_3'UTR|PCDP1_ENST00000413369.3_Missense_Mutation_p.K495T			Q4G0U5	PCDP1_HUMAN		495						cilium	calmodulin binding					Colorectal(110;0.196)					ATACTGAGAAAGATTGGCCAA	0.428000													12	31					0	0	1	0	0
IQCC	55721	broad.mit.edu	37	1	32673465	32673465	+	Missense_Mutation	SNP	C	C	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr1:32673465C>A	ENST00000537469.1	+	5	1470	c.1423C>A	c.(1423-1425)Ctc>Atc	p.L475I	IQCC_ENST00000291358.6_Missense_Mutation_p.L395I	NM_001160042.1	NP_001153514.1	Q4KMZ1	IQCC_HUMAN	IQ motif containing C	395								p.L395I(1)		endometrium(4)|large_intestine(1)|lung(3)|ovary(4)|skin(2)|urinary_tract(1)	15		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.186)				GCATAGTGTCCTCGATCTCTG	0.542000													7	111					0.248553	0.249311	1	1	0
CD160	11126	broad.mit.edu	37	1	145698987	145698987	+	Nonsense_Mutation	SNP	C	C	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr1:145698987C>T	ENST00000369290.1	-	3	334	c.177G>A	c.(175-177)tgG>tgA	p.W59*	CD160_ENST00000369288.2_Nonsense_Mutation_p.W168*|CD160_ENST00000401557.3_Nonsense_Mutation_p.W168*|CD160_ENST00000235933.6_Nonsense_Mutation_p.W168*			O95971	BY55_HUMAN	CD160 molecule	168	Ig-like V-type.				cell proliferation|cell surface receptor linked signaling pathway|cellular defense response|regulation of immune response	anchored to plasma membrane	MHC class I receptor activity|receptor binding			endometrium(3)|large_intestine(2)|lung(2)	7	all_hematologic(18;0.00473)|Acute lymphoblastic leukemia(18;0.0786)		KIRC - Kidney renal clear cell carcinoma(6;0.0764)|Kidney(552;0.118)|Colorectal(543;0.229)			CCAGCATTACCCAGACCTTTT	0.483000													9	81					0	0	1	0	0
TRPC5	7224	broad.mit.edu	37	X	111019952	111019952	+	Silent	SNP	G	G	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chrX:111019952G>A	ENST00000262839.2	-	11	3429	c.2511C>T	c.(2509-2511)ttC>ttT	p.F837F		NM_012471.2	NP_036603.1	Q9UL62	TRPC5_HUMAN	transient receptor potential cation channel, subfamily C, member 5	837					axon guidance	calcium channel complex|integral to plasma membrane	protein binding|store-operated calcium channel activity			biliary_tract(1)|breast(4)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(38)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	62						AAGGACCCATGAAGGAGCGTT	0.458000													29	106					0	0	1	0	0
SNHG14	104472715	broad.mit.edu	37	15	25475907	25475907	+	RNA	SNP	T	T	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr15:25475907T>A	ENST00000453082.2	+	0	1502					NR_003343.1																						CAGCCCTTCCTGGCGCCCTGG	0.602000													16	101					0	0	1	0	0
ACPT	93650	broad.mit.edu	37	19	51298336	51298336	+	Missense_Mutation	SNP	T	T	C			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr19:51298336T>C	ENST00000270593.1	+	11	1202	c.1202T>C	c.(1201-1203)gTg>gCg	p.V401A	ACPT_ENST00000270594.3_Missense_Mutation_p.V308A	NM_033068.2	NP_149059.1	Q9BZG2	PPAT_HUMAN	acid phosphatase, testicular	401						integral to membrane	acid phosphatase activity			central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|lung(6)|skin(3)	11		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00641)|GBM - Glioblastoma multiforme(134;0.028)		GCTGTAGCTGTGCTGGTGGCA	0.687000													4	18					0	0	1	0	0
GFAP	2670	broad.mit.edu	37	17	42990719	42990719	+	Missense_Mutation	SNP	G	G	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr17:42990719G>T	ENST00000253408.5	-	4	763	c.698C>A	c.(697-699)gCa>gAa	p.A233E	GFAP_ENST00000435360.2_Missense_Mutation_p.A233E|GFAP_ENST00000588735.1_Intron|GFAP_ENST00000586793.1_Missense_Mutation_p.A233E	NM_002055.4	NP_002046.1	P14136	GFAP_HUMAN	glial fibrillary acidic protein	233	Coil 2A.|Rod.					cytoplasm|intermediate filament	structural constituent of cytoskeleton			endometrium(3)|kidney(1)|large_intestine(2)|liver(1)|lung(11)|ovary(1)|pancreas(1)|skin(2)|urinary_tract(1)	23		Prostate(33;0.0959)				TTTCAGGGCTGCGGTGAGGTC	0.617000													14	104					6.72482e-11	8.94828e-11	1	1	0
POFUT1	23509	broad.mit.edu	37	20	30804481	30804481	+	Missense_Mutation	SNP	G	G	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr20:30804481G>T	ENST00000375749.3	+	4	561	c.499G>T	c.(499-501)Ggc>Tgc	p.G167C	POFUT1_ENST00000486717.1_3'UTR|POFUT1_ENST00000375730.3_Missense_Mutation_p.G167C|POFUT1_ENST00000539210.1_Intron	NM_015352.1	NP_056167.1	Q9H488	OFUT1_HUMAN	protein O-fucosyltransferase 1	167					fucose metabolic process|Notch signaling pathway|O-glycan processing|regulation of transcription, DNA-dependent	endoplasmic reticulum|membrane	peptide-O-fucosyltransferase activity			breast(1)|endometrium(1)|large_intestine(1)|lung(2)|urinary_tract(1)	6			UCEC - Uterine corpus endometrioid carcinoma (5;0.0241)			GCTTTTTACAGGCATTTCCTT	0.507000													10	78					0.010729	0.0111356	1	1	0
KRT25	147183	broad.mit.edu	37	17	38907313	38907313	+	Nonsense_Mutation	SNP	G	G	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr17:38907313G>A	ENST00000312150.4	-	5	910	c.850C>T	c.(850-852)Cag>Tag	p.Q284*		NM_181534.3	NP_853512.1	Q7Z3Z0	K1C25_HUMAN	keratin 25	284	Coil 2.|Rod.					cytoplasm|intermediate filament	structural molecule activity			endometrium(1)|large_intestine(4)|lung(5)|ovary(2)|prostate(4)	16		Breast(137;0.00526)				TCAGAGATCTGCTGCTGCAGG	0.483000													16	97					0	0	1	0	0
FAN1	22909	broad.mit.edu	37	15	31212784	31212784	+	Silent	SNP	C	C	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr15:31212784C>T	ENST00000362065.4	+	7	2271	c.1980C>T	c.(1978-1980)ttC>ttT	p.F660F		NM_014967.4	NP_055782.3	Q9Y2M0	FAN1_HUMAN	FANCD2/FANCI-associated nuclease 1	660					double-strand break repair via homologous recombination|nucleotide-excision repair, DNA incision	nucleus	5'-3' exonuclease activity|5'-flap endonuclease activity|DNA binding|magnesium ion binding|phosphodiesterase I activity|ubiquitin binding			autonomic_ganglia(2)|breast(2)|cervix(2)|endometrium(7)|kidney(1)|large_intestine(6)|lung(8)|skin(1)	29						TGCGGTGTTTCACTGTTGGGT	0.393000								Direct reversal of damage					16	44					0	0	1	0	0
ZNF700	90592	broad.mit.edu	37	19	12059766	12059766	+	Silent	SNP	A	A	G			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr19:12059766A>G	ENST00000482090.1	+	3	1291	c.873A>G	c.(871-873)aaA>aaG	p.K291K	ZNF763_ENST00000538752.1_Intron|ZNF763_ENST00000590798.1_Intron|CTD-2006C1.12_ENST00000586394.1_RNA|ZNF700_ENST00000254321.5_Silent_p.K309K|ZNF763_ENST00000591944.1_Intron			Q9H0M5	ZN700_HUMAN	zinc finger protein 700	309					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding		ZNF700/MAST1_ENST00000251472(2)	breast(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(9)|lung(13)|pancreas(1)|prostate(1)|urinary_tract(1)	33						ATCAATGCAAAGAATGTGGAA	0.393000													28	40					0	0	1	0	0
DZIP3	9666	broad.mit.edu	37	3	108403079	108403079	+	Missense_Mutation	SNP	G	G	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr3:108403079G>T	ENST00000361582.3	+	27	3130	c.2900G>T	c.(2899-2901)gGa>gTa	p.G967V	DZIP3_ENST00000463306.1_Missense_Mutation_p.G967V	NM_014648.3	NP_055463.1	Q86Y13	DZIP3_HUMAN	DAZ interacting zinc finger protein 3	967					protein polyubiquitination	cytoplasm	polyubiquitin binding|RNA binding|ubiquitin-protein ligase activity|zinc ion binding			breast(3)|central_nervous_system(1)|endometrium(3)|large_intestine(9)|lung(21)|ovary(1)|pancreas(1)|prostate(5)|skin(1)	45						CAGTTCTTAGGAAGACCTCTT	0.378000													23	200					9.95505e-16	1.4205e-15	1	1	0
ZNF91	7644	broad.mit.edu	37	19	23544936	23544936	+	Missense_Mutation	SNP	G	G	C			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr19:23544936G>C	ENST00000300619.7	-	4	1050	c.845C>G	c.(844-846)aCt>aGt	p.T282S	ZNF91_ENST00000397082.2_Missense_Mutation_p.T250S|ZNF91_ENST00000599743.1_Intron	NM_003430.2	NP_003421.2	Q05481	ZNF91_HUMAN	zinc finger protein 91	282						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding						all_lung(12;0.0349)|Lung NSC(12;0.0538)|all_epithelial(12;0.0611)				CTTATGTCTAGTTAGGGTTGA	0.383000													7	81					0	0	1	0	0
ZNF440	126070	broad.mit.edu	37	19	11943075	11943075	+	Missense_Mutation	SNP	C	C	G			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr19:11943075C>G	ENST00000304060.5	+	4	1248	c.1084C>G	c.(1084-1086)Cac>Gac	p.H362D		NM_152357.2	NP_689570.2	Q8IYI8	ZN440_HUMAN	zinc finger protein 440	362					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(3)|endometrium(4)|kidney(1)|large_intestine(7)|lung(9)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	27						TGAAAAAATTCACAGTGGAGA	0.388000													8	65					0	0	1	0	0
SLC1A1	6505	broad.mit.edu	37	9	4583043	4583043	+	Missense_Mutation	SNP	C	C	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr9:4583043C>T	ENST00000262352.3	+	11	1435	c.1199C>T	c.(1198-1200)aCg>aTg	p.T400M		NM_004170.5	NP_004161.4	P43005	EAA3_HUMAN	solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1	400					D-aspartate import|L-glutamate import|synaptic transmission	integral to plasma membrane|membrane fraction	high-affinity glutamate transmembrane transporter activity|sodium:dicarboxylate symporter activity			endometrium(1)|kidney(1)|large_intestine(7)|lung(4)|pancreas(1)|skin(1)	15		Acute lymphoblastic leukemia(2;0.0359)|Breast(48;0.0457)		GBM - Glioblastoma multiforme(50;0.0124)|Lung(218;0.183)	L-Aspartic Acid(DB00128)|L-Glutamic Acid(DB00142)	TGCAGTATCACGGCCACATCT	0.592000													23	51					0	0	1	0	0
HCN1	348980	broad.mit.edu	37	5	45303771	45303771	+	Missense_Mutation	SNP	T	T	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr5:45303771T>A	ENST00000303230.4	-	6	1605	c.1548A>T	c.(1546-1548)caA>caT	p.Q516H		NM_021072.3	NP_066550.2	O60741	HCN1_HUMAN	hyperpolarization activated cyclic nucleotide-gated potassium channel 1	516						integral to membrane	cAMP binding|sodium channel activity|voltage-gated potassium channel activity			NS(3)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(21)|liver(1)|lung(98)|ovary(1)|prostate(7)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(5)	156						CAACACCGTGTTGAATGAAAT	0.388000													75	79					0	0	1	0	0
CACNB1	782	broad.mit.edu	37	17	37343158	37343158	+	Missense_Mutation	SNP	C	C	G			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr17:37343158C>G	ENST00000394303.3	-	5	646	c.439G>C	c.(439-441)Ggg>Cgg	p.G147R	CACNB1_ENST00000394310.3_Missense_Mutation_p.G147R|CACNB1_ENST00000582877.1_5'UTR|CACNB1_ENST00000344140.5_Missense_Mutation_p.G147R	NM_000723.4	NP_000714.3	Q02641	CACB1_HUMAN	calcium channel, voltage-dependent, beta 1 subunit	147	SH3.				axon guidance	voltage-gated calcium channel complex		p.G147R(2)		breast(1)|endometrium(3)|kidney(1)|large_intestine(4)|liver(1)|lung(3)|ovary(1)|prostate(1)|skin(1)	16					Ibutilide(DB00308)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Verapamil(DB00661)	ACCAGCCGCCCGATCCACCAG	0.562000													10	52					0	0	1	0	0
CCDC63	160762	broad.mit.edu	37	12	111321917	111321917	+	Missense_Mutation	SNP	C	C	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr12:111321917C>A	ENST00000308208.5	+	8	1179	c.937C>A	c.(937-939)Ctg>Atg	p.L313M	CCDC63_ENST00000552694.1_Missense_Mutation_p.L234M|CCDC63_ENST00000545036.1_Missense_Mutation_p.L273M	NM_152591.1	NP_689804.1	Q8NA47	CCD63_HUMAN	coiled-coil domain containing 63	313										NS(2)|breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(15)|ovary(1)|pancreas(1)|prostate(2)|skin(7)|urinary_tract(1)	39						GCTGCTGAAGCTGGCTGAGAG	0.493000													16	98					6.72482e-11	8.94828e-11	1	1	0
UGT2A3	79799	broad.mit.edu	37	4	69796263	69796263	+	Splice_Site	SNP	C	C	A	rs146748259		TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr4:69796263C>A	ENST00000251566.4	-	5	1335		c.e5+1		UGT2A3_ENST00000420231.2_Splice_Site	NM_024743.3	NP_079019.3	Q6UWM9	UD2A3_HUMAN	UDP glucuronosyltransferase 2 family, polypeptide A3							integral to membrane	glucuronosyltransferase activity			NS(1)|breast(1)|central_nervous_system(1)|kidney(5)|large_intestine(7)|lung(16)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	36						GTAGTACTTACGAGGAATCGG	0.373000													16	119					3.45872e-05	3.91089e-05	1	1	0
OR10H1	26539	broad.mit.edu	37	19	15918389	15918389	+	Missense_Mutation	SNP	C	C	G			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr19:15918389C>G	ENST00000334920.2	-	1	547	c.459G>C	c.(457-459)ttG>ttC	p.L153F		NM_013940.2	NP_039228.1	Q9Y4A9	O10H1_HUMAN	olfactory receptor, family 10, subfamily H, member 1	153					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.L153F(1)		cervix(1)|endometrium(3)|kidney(4)|large_intestine(6)|lung(8)|ovary(4)|skin(2)|urinary_tract(1)	29						TCCCCATGACCAAGCCACCAG	0.622000													34	69					0	0	1	0	0
TNXB	7148	broad.mit.edu	37	6	32017802	32017802	+	Missense_Mutation	SNP	C	C	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr6:32017802C>A	ENST00000375244.3	-	27	9613	c.9412G>T	c.(9412-9414)Ggc>Tgc	p.G3138C	TNXB_ENST00000375247.2_Missense_Mutation_p.G3136C			P22105	TENX_HUMAN	tenascin XB	3183	Fibronectin type-III 23.				actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|prostate(1)	8						GACACAGGGCCTACGCGCTGG	0.627000													22	64					6.44725e-10	8.39761e-10	1	1	0
RYR2	6262	broad.mit.edu	37	1	237711840	237711840	+	Missense_Mutation	SNP	G	G	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr1:237711840G>A	ENST00000366574.2	+	26	3333	c.3016G>A	c.(3016-3018)Gtg>Atg	p.V1006M	RYR2_ENST00000542537.1_Missense_Mutation_p.V990M|RYR2_ENST00000360064.6_Missense_Mutation_p.V1004M	NM_001035.2	NP_001026.2	Q92736	RYR2_HUMAN	ryanodine receptor 2 (cardiac)	1006	4 X approximate repeats.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			NS(4)|breast(8)|central_nervous_system(11)|cervix(2)|endometrium(39)|haematopoietic_and_lymphoid_tissue(5)|kidney(17)|large_intestine(83)|liver(4)|lung(353)|ovary(18)|pancreas(5)|prostate(12)|skin(8)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(4)	586	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			TGCACATAATGTGTGGGCGCG	0.488000													19	33					0	0	1	0	0
ABCC3	8714	broad.mit.edu	37	17	48764929	48764929	+	Missense_Mutation	SNP	G	G	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr17:48764929G>A	ENST00000285238.8	+	30	4393	c.4313G>A	c.(4312-4314)cGa>cAa	p.R1438Q		NM_003786.3	NP_003777.2	O15438	MRP3_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 3	1438	ABC transporter 2.				bile acid metabolic process	integral to plasma membrane|membrane fraction	ATP binding|bile acid-exporting ATPase activity|organic anion transmembrane transporter activity			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(6)|liver(1)|lung(11)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	33			BRCA - Breast invasive adenocarcinoma(22;3.05e-09)		Glibenclamide(DB01016)	TGCCTGGCCCGAGCCCTGCTC	0.647000													11	71					0	0	1	0	0
BMPER	168667	broad.mit.edu	37	7	34006120	34006120	+	Missense_Mutation	SNP	A	A	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr7:34006120A>T	ENST00000297161.2	+	5	723	c.349A>T	c.(349-351)Agc>Tgc	p.S117C	BMPER_ENST00000426693.1_Missense_Mutation_p.S117C	NM_133468.4	NP_597725.1	Q8N8U9	BMPER_HUMAN	BMP binding endothelial regulator	117	VWFC 2.				blood vessel endothelial cell proliferation involved in sprouting angiogenesis|endothelial cell activation|negative regulation of BMP signaling pathway|positive regulation of ERK1 and ERK2 cascade|regulation of endothelial cell migration|regulation of pathway-restricted SMAD protein phosphorylation	extracellular space				breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(7)|lung(24)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	48						TACCTATAACAGCTCCTTCAA	0.453000													13	44					0	0	1	0	0
TNK2	10188	broad.mit.edu	37	3	195594618	195594618	+	Missense_Mutation	SNP	G	G	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr3:195594618G>A	ENST00000333602.6	-	12	3123	c.2506C>T	c.(2506-2508)Cct>Tct	p.P836S	TNK2_ENST00000428187.1_Missense_Mutation_p.P868S|TNK2_ENST00000392400.1_Missense_Mutation_p.P836S|TNK2_ENST00000381916.2_Missense_Mutation_p.P914S	NM_005781.4	NP_005772.3	Q07912	ACK1_HUMAN	tyrosine kinase, non-receptor, 2	836	EBD domain (By similarity).|Pro-rich.			Missing (in Ref. 4; AAH08884).	positive regulation of peptidyl-tyrosine phosphorylation|protein ubiquitination|small GTPase mediated signal transduction	adherens junction|cytoplasmic vesicle membrane|endosome|nucleus	ATP binding|GTPase inhibitor activity|metal ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding			central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(11)|ovary(3)|prostate(4)|skin(2)|stomach(1)|urinary_tract(1)	29	all_cancers(143;6.48e-09)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;1.46e-22)|OV - Ovarian serous cystadenocarcinoma(49;8.3e-19)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;0.000757)	Adenosine triphosphate(DB00171)	CGCGGGCCAGGGGCCTGGATC	0.652000													16	20					0	0	1	0	0
DSCAM	1826	broad.mit.edu	37	21	41496256	41496256	+	Splice_Site	SNP	C	C	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr21:41496256C>T	ENST00000400454.1	-	20	4040		c.e20-1			NM_001389.3	NP_001380.2	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule						cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(22)|lung(47)|ovary(7)|pancreas(2)|prostate(3)|skin(14)|upper_aerodigestive_tract(6)|urinary_tract(4)	142		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				GGACCTGGAACTGGAAGAGCC	0.597000													11	85					0	0	1	0	0
ACPT	93650	broad.mit.edu	37	19	51298183	51298183	+	Missense_Mutation	SNP	T	T	C			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr19:51298183T>C	ENST00000270593.1	+	10	1127	c.1127T>C	c.(1126-1128)gTc>gCc	p.V376A	ACPT_ENST00000270594.3_Missense_Mutation_p.V283A	NM_033068.2	NP_149059.1	Q9BZG2	PPAT_HUMAN	acid phosphatase, testicular	376						integral to membrane	acid phosphatase activity			central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|lung(6)|skin(3)	11		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00641)|GBM - Glioblastoma multiforme(134;0.028)		GCCCATGGGGTCTCCTGCCAT	0.706000													24	109					0	0	1	0	0
FGD5	152273	broad.mit.edu	37	3	14862555	14862555	+	Silent	SNP	G	G	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr3:14862555G>A	ENST00000285046.5	+	1	2087	c.1977G>A	c.(1975-1977)ctG>ctA	p.L659L	FGD5_ENST00000543601.1_Silent_p.L418L	NM_152536.3	NP_689749.3	Q6ZNL6	FGD5_HUMAN	FYVE, RhoGEF and PH domain containing 5	659					actin cytoskeleton organization|filopodium assembly|regulation of Cdc42 GTPase activity|regulation of cell shape	cytoskeleton|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			NS(2)|breast(2)|endometrium(3)|kidney(5)|large_intestine(10)|lung(25)|ovary(3)|pancreas(1)|prostate(2)|urinary_tract(1)	54						TCCTGGCACTGACGTTTAAGA	0.507000													11	70					0	0	1	0	0
UNC79	57578	broad.mit.edu	37	14	94088083	94088083	+	Missense_Mutation	SNP	C	C	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr14:94088083C>T	ENST00000553484.1	+	31	4724	c.4570C>T	c.(4570-4572)Ctt>Ttt	p.L1524F	UNC79_ENST00000393151.2_Missense_Mutation_p.L1502F|UNC79_ENST00000555664.1_Missense_Mutation_p.L1502F|UNC79_ENST00000256339.4_Missense_Mutation_p.L1325F			Q9P2D8	UNC79_HUMAN	unc-79 homolog (C. elegans)	1502						integral to membrane				breast(3)|cervix(2)|endometrium(10)|kidney(7)|large_intestine(18)|liver(1)|lung(64)|ovary(1)|prostate(5)|skin(3)|urinary_tract(4)	118						ACAAAAATCTCTTGATATAGG	0.433000													33	64					0	0	1	0	0
FAM47C	442444	broad.mit.edu	37	X	37028252	37028252	+	Missense_Mutation	SNP	G	G	A	rs139503125		TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chrX:37028252G>A	ENST00000358047.3	+	1	1821	c.1769G>A	c.(1768-1770)cGg>cAg	p.R590Q		NM_001013736.2	NP_001013758.1	Q5HY64	FA47C_HUMAN	family with sequence similarity 47, member C	590										breast(4)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(15)|lung(63)|ovary(6)|pancreas(1)|prostate(6)|skin(8)|upper_aerodigestive_tract(4)|urinary_tract(1)	120						CCCAAGACTCGGGTGTCCAGT	0.652000													52	51					0	0	1	0	0
OR2M4	26245	broad.mit.edu	37	1	248402675	248402675	+	Missense_Mutation	SNP	T	T	C			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr1:248402675T>C	ENST00000306687.1	+	1	445	c.445T>C	c.(445-447)Tgg>Cgg	p.W149R		NM_017504.1	NP_059974.1	Q96R27	OR2M4_HUMAN	olfactory receptor, family 2, subfamily M, member 4	149					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(8)|lung(27)|skin(3)|upper_aerodigestive_tract(2)	50	all_cancers(71;0.000124)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			TGTTGCTTCCTGGACCTTGGG	0.468000													23	165					0	0	1	0	0
DARC	2532	broad.mit.edu	37	1	159175418	159175418	+	Silent	SNP	C	C	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr1:159175418C>A	ENST00000537147.1	+	3	1032	c.189C>A	c.(187-189)ccC>ccA	p.P63P	DARC_ENST00000368121.2_Silent_p.P65P|DARC_ENST00000368122.2_Silent_p.P63P			Q16570	DUFFY_HUMAN	Duffy blood group, atypical chemokine receptor	63					defense response	integral to membrane|plasma membrane	C-C chemokine binding|chemokine receptor activity			large_intestine(2)|lung(1)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	8	all_hematologic(112;0.0429)					CTGCACTGCCCTTCTTCATCC	0.562000													65	114					3.7469e-33	5.75458e-33	1	1	0
COLGALT2	23127	broad.mit.edu	37	1	183933060	183933060	+	Silent	SNP	G	G	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr1:183933060G>T	ENST00000361927.4	-	6	1298	c.927C>A	c.(925-927)ctC>ctA	p.L309L	COLGALT2_ENST00000367520.3_Silent_p.L46L|COLGALT2_ENST00000546159.1_Silent_p.L309L	NM_015101.2	NP_055916.1			collagen beta(1-O)galactosyltransferase 2																		GCACATGGATGAGGTTCTCGA	0.552000													13	66					9.31168e-06	1.0751e-05	1	1	0
GLIS1	148979	broad.mit.edu	37	1	53974961	53974961	+	Splice_Site	SNP	C	C	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr1:53974961C>A	ENST00000312233.2	-	9	2104		c.e9-1			NM_147193.2	NP_671726.2	Q8NBF1	GLIS1_HUMAN	GLIS family zinc finger 1						negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleus	DNA binding|zinc ion binding			endometrium(3)|kidney(2)|large_intestine(3)|liver(1)|lung(7)|ovary(1)|skin(3)|urinary_tract(4)	24						CCCTGGTAACCTGCAGACGGG	0.632000													3	9					6.4e-05	7.11589e-05	1	1	0
AKAP11	11215	broad.mit.edu	37	13	42876707	42876707	+	Silent	SNP	A	A	G			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr13:42876707A>G	ENST00000025301.2	+	8	4000	c.3825A>G	c.(3823-3825)gcA>gcG	p.A1275A		NM_016248.3	NP_057332.1	Q9UKA4	AKA11_HUMAN	A kinase (PRKA) anchor protein 11	1275					intracellular protein kinase cascade	microtubule organizing center	protein kinase A binding|protein phosphatase 1 binding			breast(3)|central_nervous_system(4)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(10)|liver(1)|lung(22)|ovary(1)|skin(3)|stomach(2)	56		Lung NSC(96;1.86e-05)|Prostate(109;0.0165)|Lung SC(185;0.0262)|Breast(139;0.0707)|Hepatocellular(98;0.114)		OV - Ovarian serous cystadenocarcinoma(117;0.000365)|GBM - Glioblastoma multiforme(144;0.00116)|BRCA - Breast invasive adenocarcinoma(63;0.19)		AGAAAATAGCAAAAGTCCGAA	0.378000													35	49					0	0	1	0	0
CETN1	1068	broad.mit.edu	37	18	580861	580861	+	Silent	SNP	G	G	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr18:580861G>T	ENST00000327228.3	+	1	495	c.453G>T	c.(451-453)cgG>cgT	p.R151R		NM_004066.1	NP_004057.1	Q12798	CETN1_HUMAN	centrin, EF-hand protein, 1	151	EF-hand 4.				cell division|mitosis	spindle pole	ATP binding|ATP-dependent helicase activity|calcium ion binding|nucleic acid binding			breast(2)|cervix(1)|endometrium(3)|large_intestine(6)|lung(9)|ovary(2)|upper_aerodigestive_tract(2)	25						AAGCTGATCGGGATGGGGACG	0.542000													21	63					4.35082e-09	5.57131e-09	1	1	0
LRBA	987	broad.mit.edu	37	4	151246962	151246962	+	Splice_Site	SNP	A	A	C			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr4:151246962A>C	ENST00000535741.1	-	49	7924	c.7452_splice	c.e49+1	p.V2484_splice	LRBA_ENST00000510413.1_Splice_Site_p.V2484_splice|LRBA_ENST00000357115.3_Splice_Site_p.V2495_splice|LRBA_ENST00000507224.1_Splice_Site_p.V2484_splice|LRBA_ENST00000503716.1_5'UTR			P50851	LRBA_HUMAN	LPS-responsive vesicle trafficking, beach and anchor containing	2495	BEACH.					endoplasmic reticulum|Golgi apparatus|integral to membrane|lysosome|plasma membrane	protein binding			breast(6)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(20)|lung(32)|ovary(4)|prostate(6)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	91	all_hematologic(180;0.151)					AGCACTTACCACTTGCATGGC	0.448000													4	24					0	0	1	0	0
KRTAP10-9	386676	broad.mit.edu	37	21	46047397	46047397	+	Silent	SNP	C	C	G			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr21:46047397C>G	ENST00000397911.3	+	1	358	c.309C>G	c.(307-309)gtC>gtG	p.V103V	TSPEAR_ENST00000323084.4_Intron|KRTAP10-9_ENST00000484861.1_Intron	NM_198690.2	NP_941963.2	P60411	KR109_HUMAN	keratin associated protein 10-9	103	25 X 5 AA repeats of C-C-X(3).					keratin filament				endometrium(1)|kidney(1)|large_intestine(1)|lung(6)	9						gcgtgcccgtctgctgcaagc	0.662000													32	195					0	0	1	0	0
KRT9	3857	broad.mit.edu	37	17	39723904	39723904	+	Missense_Mutation	SNP	C	C	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr17:39723904C>A	ENST00000246662.4	-	7	1558	c.1493G>T	c.(1492-1494)gGt>gTt	p.G498V	KRT9_ENST00000588431.1_Missense_Mutation_p.G265V	NM_000226.3	NP_000217.2	P35527	K1C9_HUMAN	keratin 9	498	Tail.				intermediate filament organization|skin development		protein binding|structural constituent of cytoskeleton			autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(4)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	25		Breast(137;0.000307)				tcctcctccaccatagctgcc	0.577000													6	19					0.0215528	0.0220675	1	1	0
TTN	7273	broad.mit.edu	37	2	179458544	179458544	+	Missense_Mutation	SNP	C	C	G			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr2:179458544C>G	ENST00000589042.1	-	298	58707	c.58483G>C	c.(58483-58485)Gat>Cat	p.D19495H	TTN_ENST00000342175.6_Missense_Mutation_p.D10622H|TTN-AS1_ENST00000586452.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.D10555H|TTN-AS1_ENST00000589234.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.D17854H|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000589907.1_RNA|TTN-AS1_ENST00000590932.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.D16927H|TTN-AS1_ENST00000456053.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN-AS1_ENST00000592750.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.D10430H|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000592689.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	17854	Fibronectin type-III 41.		D -> G.				ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity	p.D10555Y(1)|p.D16925Y(1)|p.D10430Y(1)|p.D10622Y(1)		NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ACCATGTAATCTTTGGTCACC	0.398000													5	41					0	0	1	0	0
VPS13C	54832	broad.mit.edu	37	15	62211564	62211564	+	Missense_Mutation	SNP	C	C	G			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr15:62211564C>G	ENST00000261517.5	-	58	7635	c.7562G>C	c.(7561-7563)aGt>aCt	p.S2521T	VPS13C_ENST00000395898.3_Missense_Mutation_p.S2478T|VPS13C_ENST00000249837.3_Missense_Mutation_p.S2478T|VPS13C_ENST00000395896.4_Missense_Mutation_p.S2521T	NM_020821.2	NP_065872.1	Q709C8	VP13C_HUMAN	vacuolar protein sorting 13 homolog C (S. cerevisiae)	2521					protein localization					NS(3)|breast(4)|endometrium(4)|kidney(9)|large_intestine(26)|lung(46)|ovary(5)|prostate(6)|skin(6)|stomach(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	117						GTCAGAATGACTGGCATTGGG	0.413000													22	116					0	0	1	0	0
LRBA	987	broad.mit.edu	37	4	151511892	151511892	+	Missense_Mutation	SNP	C	C	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr4:151511892C>A	ENST00000535741.1	-	39	6639	c.6166G>T	c.(6166-6168)Gat>Tat	p.D2056Y	LRBA_ENST00000510413.1_Missense_Mutation_p.D2056Y|LRBA_ENST00000357115.3_Missense_Mutation_p.D2067Y|LRBA_ENST00000507224.1_Missense_Mutation_p.D2056Y			P50851	LRBA_HUMAN	LPS-responsive vesicle trafficking, beach and anchor containing	2067						endoplasmic reticulum|Golgi apparatus|integral to membrane|lysosome|plasma membrane	protein binding			breast(6)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(20)|lung(32)|ovary(4)|prostate(6)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	91	all_hematologic(180;0.151)					TCTTTCTCATCCACGGATGAC	0.413000													12	60					2.68362e-12	3.64972e-12	1	1	0
ZNF99	7652	broad.mit.edu	37	19	22940810	22940810	+	Nonsense_Mutation	SNP	G	G	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr19:22940810G>T	ENST00000397104.3	-	5	1627	c.1628C>A	c.(1627-1629)tCa>tAa	p.S543*	ZNF99_ENST00000596209.1_Nonsense_Mutation_p.S634*					zinc finger protein 99											NS(1)|breast(1)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(20)|lung(55)|ovary(2)|prostate(10)|skin(5)|stomach(9)|upper_aerodigestive_tract(2)|urinary_tract(3)	124		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.102)				TCTAAGGGTTGAGGACTGGCT	0.383000													28	31					2.79863e-10	3.66948e-10	1	1	0
LRRIQ1	84125	broad.mit.edu	37	12	85515611	85515611	+	Nonsense_Mutation	SNP	C	C	T	rs148400374		TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr12:85515611C>T	ENST00000393217.2	+	16	3575	c.3514C>T	c.(3514-3516)Cga>Tga	p.R1172*		NM_001079910.1	NP_001073379.1	Q96JM4	LRIQ1_HUMAN	leucine-rich repeats and IQ motif containing 1	1172										breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(21)|liver(1)|lung(28)|ovary(5)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)	83				GBM - Glioblastoma multiforme(134;0.212)		GTCTCAGATTCGAGAATTCAA	0.348000													5	54					0	0	1	0	0
FRAS1	80144	broad.mit.edu	37	4	79396614	79396614	+	Missense_Mutation	SNP	G	G	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr4:79396614G>T	ENST00000264895.6	+	54	8145	c.7705G>T	c.(7705-7707)Ggg>Tgg	p.G2569W		NM_025074.6	NP_079350.5	Q86XX4	FRAS1_HUMAN	Fraser syndrome 1	2568	Calx-beta 1.				cell communication	integral to membrane|plasma membrane	metal ion binding			breast(2)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(5)|lung(54)|prostate(7)|skin(2)|urinary_tract(4)	103						TGAGAAGGCAGGGTCTGTCAG	0.507000													11	51					0.010729	0.0111356	1	1	0
PCDHB5	26167	broad.mit.edu	37	5	140515612	140515612	+	Missense_Mutation	SNP	C	C	T	rs61736695	byFrequency	TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr5:140515612C>T	ENST00000231134.5	+	1	813	c.596C>T	c.(595-597)gCg>gTg	p.A199V		NM_015669.2	NP_056484.1	Q9Y5E4	PCDB5_HUMAN		199	Cadherin 2.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding|protein binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(12)|kidney(1)|large_intestine(18)|lung(25)|ovary(3)|prostate(6)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(2)	81			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CTGGACAAAGCGCTGGACCGG	0.557000													28	118					0	0	1	0	0
SLC30A6	55676	broad.mit.edu	37	2	32399178	32399178	+	Missense_Mutation	SNP	G	G	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr2:32399178G>T	ENST00000282587.5	+	3	174	c.137G>T	c.(136-138)gGc>gTc	p.G46V	SLC30A6_ENST00000379343.2_Missense_Mutation_p.G46V|SLC30A6_ENST00000357055.3_5'UTR|SLC30A6_ENST00000406369.1_Intron|SLC30A6_ENST00000538303.1_Missense_Mutation_p.G17V|SLC30A6_ENST00000435660.1_Missense_Mutation_p.G46V	NM_017964.3	NP_060434.2	Q6NXT4	ZNT6_HUMAN	solute carrier family 30 (zinc transporter), member 6	46						Golgi membrane|integral to membrane	zinc ion transmembrane transporter activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(4)|lung(5)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	19	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.208)					ATATGTACTGGCTTCCTGCTT	0.328000													27	58					2.79863e-10	3.66948e-10	1	1	0
NFIL3	4783	broad.mit.edu	37	9	94172474	94172474	+	Missense_Mutation	SNP	G	G	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr9:94172474G>T	ENST00000297689.3	-	2	937	c.543C>A	c.(541-543)caC>caA	p.H181Q		NM_005384.2	NP_005375.2	Q16649	NFIL3_HUMAN	nuclear factor, interleukin 3 regulated	181	Ser-rich.				circadian rhythm|immune response|transcription from RNA polymerase II promoter	nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			endometrium(1)|large_intestine(4)|lung(9)|prostate(1)|skin(1)	16						TTTGTGGAGAGTGTTTAATGA	0.458000													26	48					8.24728e-16	1.17852e-15	1	1	0
SCAND3	114821	broad.mit.edu	37	6	28540909	28540909	+	Silent	SNP	C	C	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr6:28540909C>T	ENST00000452236.2	-	4	3374	c.2757G>A	c.(2755-2757)gtG>gtA	p.V919V		NM_052923.1	NP_443155.1	Q6R2W3	SCND3_HUMAN	SCAN domain containing 3	919					DNA integration|viral reproduction	nucleus	DNA binding|protein dimerization activity|sequence-specific DNA binding transcription factor activity			NS(3)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(14)|liver(1)|lung(29)|ovary(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(3)	71						gttcaaacctcacatagacta	0.318000													16	35					0	0	1	0	0
C2orf16	84226	broad.mit.edu	37	2	27803307	27803307	+	Missense_Mutation	SNP	A	A	G			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr2:27803307A>G	ENST00000408964.2	+	1	3919	c.3868A>G	c.(3868-3870)Atg>Gtg	p.M1290V		NM_032266.3	NP_115642.3	Q68DN1	CB016_HUMAN	chromosome 2 open reading frame 16	1290										breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(33)|urinary_tract(1)	47	Acute lymphoblastic leukemia(172;0.155)					AAAATATCCAATGAAGAGAAT	0.403000													15	87					0	0	1	0	0
BRDT	676	broad.mit.edu	37	1	92433764	92433764	+	Missense_Mutation	SNP	C	C	G			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr1:92433764C>G	ENST00000370389.2	+	4	1097	c.173C>G	c.(172-174)tCt>tGt	p.S58C	BRDT_ENST00000399546.2_Missense_Mutation_p.S131C|BRDT_ENST00000394530.3_Missense_Mutation_p.S85C|BRDT_ENST00000402388.1_Missense_Mutation_p.S131C|BRDT_ENST00000362005.3_Missense_Mutation_p.S131C	NM_001242810.1	NP_001229739.1	Q58F21	BRDT_HUMAN	bromodomain, testis-specific	131	Bromo 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein serine/threonine kinase activity|transcription coactivator activity			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|lung(24)|ovary(1)|prostate(4)|skin(2)|stomach(2)|urinary_tract(2)	56		all_lung(203;0.00531)|Lung NSC(277;0.0194)		all cancers(265;0.0228)|Epithelial(280;0.133)		CAGAAATTATCTCAGATGCCA	0.373000													23	31					0	0	1	0	0
FAT3	120114	broad.mit.edu	37	11	92523184	92523184	+	Missense_Mutation	SNP	G	G	C			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr11:92523184G>C	ENST00000298047.6	+	7	4428	c.4411G>C	c.(4411-4413)Gag>Cag	p.E1471Q	FAT3_ENST00000409404.2_Missense_Mutation_p.E1471Q|FAT3_ENST00000525166.1_Missense_Mutation_p.E1321Q			Q8TDW7	FAT3_HUMAN	FAT atypical cadherin 3	1471	Cadherin 14.				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(10)|kidney(4)|large_intestine(11)|liver(2)|lung(37)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	85		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				GACAATTTCCGAGGATGTGCT	0.423000										TCGA Ovarian(4;0.039)			18	130					0	0	1	0	0
ZSCAN10	84891	broad.mit.edu	37	16	3139483	3139483	+	Missense_Mutation	SNP	C	C	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr16:3139483C>A	ENST00000252463.2	-	5	1874	c.1787G>T	c.(1786-1788)cGc>cTc	p.R596L	ZSCAN10_ENST00000538082.2_Missense_Mutation_p.R514L|ZSCAN10_ENST00000575108.1_Missense_Mutation_p.R257L	NM_032805.1	NP_116194.1	Q96SZ4	ZSC10_HUMAN	zinc finger and SCAN domain containing 10	596					negative regulation of transcription, DNA-dependent|viral reproduction	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|cervix(3)|endometrium(3)|kidney(1)|lung(8)|ovary(2)|prostate(1)|skin(4)|urinary_tract(1)	24						GCGCTGGTGGCGCGCCAGGTG	0.711000													5	40					0.000602214	0.000652509	1	1	0
BLZF1	8548	broad.mit.edu	37	1	169347741	169347741	+	Silent	SNP	A	A	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr1:169347741A>T	ENST00000367808.3	+	4	1065	c.642A>T	c.(640-642)gtA>gtT	p.V214V	BLZF1_ENST00000329281.2_Silent_p.V214V			Q9H2G9	GO45_HUMAN	basic leucine zipper nuclear factor 1	214					cell proliferation|Golgi organization|Golgi to plasma membrane protein transport|regulation of cell growth|regulation of transcription from RNA polymerase II promoter	Golgi lumen|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|ubiquitin protein ligase binding			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(4)|prostate(1)|skin(1)	14	all_hematologic(923;0.208)					AGTGTGATGTATGGCGAAGTA	0.373000													14	133					0	0	1	0	0
USP14	9097	broad.mit.edu	37	18	210491	210491	+	Missense_Mutation	SNP	A	A	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr18:210491A>T	ENST00000261601.6	+	15	1422	c.1331A>T	c.(1330-1332)cAa>cTa	p.Q444L	USP14_ENST00000582707.1_Missense_Mutation_p.Q409L|USP14_ENST00000383589.2_Missense_Mutation_p.Q398L|USP14_ENST00000400266.3_Missense_Mutation_p.Q433L	NM_005151.3	NP_005142.1	P54578	UBP14_HUMAN	ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase)	444					regulation of chemotaxis|regulation of proteasomal protein catabolic process|ubiquitin-dependent protein catabolic process	cell surface|cytoplasmic membrane-bounded vesicle|plasma membrane|proteasome complex	cysteine-type endopeptidase activity|endopeptidase inhibitor activity|proteasome binding|tRNA guanylyltransferase activity|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			endometrium(1)|large_intestine(1)|lung(5)|ovary(2)|skin(2)	11		all_cancers(4;0.0896)|Myeloproliferative disorder(11;0.0412)				AAAAGGAAACAAGGTAAAGGG	0.338000													11	60					0	0	1	0	0
WDR18	57418	broad.mit.edu	37	19	992088	992088	+	Silent	SNP	G	G	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr19:992088G>T	ENST00000251289.5	+	8	1088	c.1065G>T	c.(1063-1065)ggG>ggT	p.G355G	WDR18_ENST00000587001.2_Silent_p.G355G	NM_024100.3	NP_077005.2	Q9BV38	WDR18_HUMAN	WD repeat domain 18	355										endometrium(1)|kidney(2)|lung(2)|skin(2)	7		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.04e-05)|all_lung(49;1.53e-05)|Breast(49;9.42e-05)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CGCGCCACGGGGGCCTCACTC	0.716000													3	8					0.150653	0.151731	1	1	0
CALN1	83698	broad.mit.edu	37	7	71571179	71571179	+	Silent	SNP	G	G	A	rs139754746		TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr7:71571179G>A	ENST00000395275.2	-	4	733	c.345C>T	c.(343-345)agC>agT	p.S115S	CALN1_ENST00000412588.1_Silent_p.S115S|CALN1_ENST00000329008.5_Silent_p.S73S|CALN1_ENST00000405452.2_Silent_p.S73S|CALN1_ENST00000395276.2_Silent_p.S73S|CALN1_ENST00000431984.1_Silent_p.S73S	NM_031468.3	NP_113656.2	Q9BXU9	CABP8_HUMAN	calneuron 1	73						Golgi apparatus|integral to membrane|perinuclear region of cytoplasm|plasma membrane	calcium ion binding			biliary_tract(1)|breast(1)|endometrium(3)|large_intestine(6)|lung(19)|skin(2)	32		all_cancers(73;0.069)|Lung NSC(55;0.0658)|all_lung(88;0.0912)|all_epithelial(88;0.161)				GCTCCACCTCGCTTGGCATGT	0.592000													18	40					0	0	1	0	0
CD84	8832	broad.mit.edu	37	1	160520761	160520761	+	Silent	SNP	C	C	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr1:160520761C>T	ENST00000368054.3	-	5	860	c.825G>A	c.(823-825)gaG>gaA	p.E275E	CD84_ENST00000534968.1_Silent_p.E161E|CD84_ENST00000311224.4_Silent_p.E292E|CD84_ENST00000368051.3_Intron|CD84_ENST00000368048.3_Silent_p.E286E|RP11-528G1.2_ENST00000446952.1_RNA	NM_003874.3	NP_003865.1	Q9UIB8	SLAF5_HUMAN	CD84 molecule	292					blood coagulation|defense response|homophilic cell adhesion|leukocyte migration	integral to plasma membrane	receptor activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(12)|ovary(2)|prostate(1)|skin(1)	24	all_cancers(52;3.62e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.0175)			AGATTCTGGACTCTGCTGGCT	0.473000													29	229					0	0	1	0	0
MAMDC4	158056	broad.mit.edu	37	9	139751466	139751466	+	Missense_Mutation	SNP	T	T	G			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr9:139751466T>G	ENST00000445819.1	+	18	2232	c.2182T>G	c.(2182-2184)Tgg>Ggg	p.W728G	MAMDC4_ENST00000485732.1_3'UTR|MAMDC4_ENST00000317446.2_Missense_Mutation_p.W649G			Q6UXC1	AEGP_HUMAN	MAM domain containing 4	728	MAM 4.				protein transport	integral to membrane				breast(4)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(1)|lung(4)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(2)	19	all_cancers(76;0.0763)|all_epithelial(76;0.198)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;1.52e-05)|Epithelial(140;0.000171)		TCTCAGCTTCTGGTACCACCT	0.677000													5	34					0	0	1	0	0
FUBP1	8880	broad.mit.edu	37	1	78428501	78428501	+	Missense_Mutation	SNP	G	G	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr1:78428501G>A	ENST00000370767.1	-	14	1385	c.1298C>T	c.(1297-1299)cCa>cTa	p.P433L	FUBP1_ENST00000370768.2_Missense_Mutation_p.P433L|FUBP1_ENST00000436586.2_Missense_Mutation_p.P454L			Q96AE4	FUBP1_HUMAN	far upstream element (FUSE) binding protein 1	433	KH 4.				transcription from RNA polymerase II promoter	nucleus	protein binding|RNA binding|sequence-specific DNA binding transcription factor activity|single-stranded DNA binding			central_nervous_system(7)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(4)|lung(1)|upper_aerodigestive_tract(3)	17						TATCTGTTGTGGAGTGCCACG	0.368000			"""F, N"""		oligodendroglioma								16	151					0	0	1	0	0
C4orf3	401152	broad.mit.edu	37	4	120221657	120221657	+	Missense_Mutation	SNP	C	C	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr4:120221657C>A	ENST00000399075.4	-	2	432	c.433G>T	c.(433-435)Gat>Tat	p.D145Y	C4orf3_ENST00000504110.1_Missense_Mutation_p.D12Y	NM_001170330.1	NP_001163801.1	Q8WVX3	CD003_HUMAN	chromosome 4 open reading frame 3	12						integral to membrane				breast(1)|large_intestine(1)|lung(4)	6						CGGAGACCATCTCGACCATCA	0.567000													17	92					4.96729e-08	6.19184e-08	1	1	0
C7	730	broad.mit.edu	37	5	40981624	40981624	+	Silent	SNP	G	G	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr5:40981624G>T	ENST00000313164.9	+	18	2840	c.2481G>T	c.(2479-2481)ggG>ggT	p.G827G		NM_000587.2	NP_000578.2	P10643	CO7_HUMAN	complement component 7	827	Complement control factor I module 2.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis	extracellular region|membrane attack complex							Ovarian(839;0.0112)				GATGCAGAGGGCAGAGCATCT	0.582000													7	49					8.12818e-05	8.98474e-05	1	1	0
KCNH7	90134	broad.mit.edu	37	2	163693208	163693208	+	Missense_Mutation	SNP	C	C	A			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr2:163693208C>A	ENST00000332142.5	-	2	245	c.146G>T	c.(145-147)tGt>tTt	p.C49F	KCNH7_ENST00000328032.4_Missense_Mutation_p.C49F	NM_033272.3	NP_150375.2	Q9NS40	KCNH7_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 7	49	PAS.				regulation of transcription, DNA-dependent	integral to membrane	protein binding|signal transducer activity			NS(1)|biliary_tract(1)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(22)|lung(53)|ovary(3)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(3)	108					Ibutilide(DB00308)	AGTCATCTCACAGAACCCATC	0.433000													16	59					4.14922e-12	5.63516e-12	1	1	0
ARHGEF4	50649	broad.mit.edu	37	2	131704106	131704106	+	Missense_Mutation	SNP	T	T	C			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr2:131704106T>C	ENST00000409359.1	+	4	4091	c.2893T>C	c.(2893-2895)Tct>Cct	p.S965P	ARHGEF4_ENST00000326016.5_Missense_Mutation_p.S109P|ARHGEF4_ENST00000409303.1_Missense_Mutation_p.S109P|ARHGEF4_ENST00000428230.2_Missense_Mutation_p.S109P|ARHGEF4_ENST00000525839.1_Missense_Mutation_p.S109P|ARHGEF4_ENST00000392953.3_Missense_Mutation_p.S109P			Q9NR80	ARHG4_HUMAN	Rho guanine nucleotide exchange factor (GEF) 4	109					apoptosis|filopodium assembly|induction of apoptosis by extracellular signals|lamellipodium assembly|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|ruffle membrane	protein domain specific binding|Rac guanyl-nucleotide exchange factor activity			NS(1)|breast(4)|cervix(1)|endometrium(2)|large_intestine(5)|lung(7)|ovary(3)|pancreas(1)|prostate(1)|skin(4)	29		Prostate(154;0.055)		BRCA - Breast invasive adenocarcinoma(221;0.097)		GATCATTACCTCTCCAGAGTC	0.517000													17	131					0	0	1	0	0
ABCG8	64241	broad.mit.edu	37	2	44073420	44073420	+	Frame_Shift_Del	DEL	G	G	-			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr2:44073420delG	ENST00000272286.2	+	3	382	c.292delG	c.(292-294)ggfs	p.G98fs		NM_022437.2	NP_071882.1	Q9H221	ABCG8_HUMAN	ATP-binding cassette, sub-family G (WHITE), member 8	98	ABC transporter.				cholesterol efflux|cholesterol homeostasis|excretion|lipid metabolic process|negative regulation of intestinal cholesterol absorption|negative regulation of intestinal phytosterol absorption	apical plasma membrane|integral to membrane	ATP binding|ATPase activity|protein heterodimerization activity	p.G98W(1)		NS(1)|breast(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(5)|lung(21)|ovary(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	45		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)				AGTGAGAAGTGGGCAGATGCT	0.522													32	79	---	---	---	---					
MMRN1	22915	broad.mit.edu	37	4	90830461	90830461	+	Frame_Shift_Del	DEL	C	C	-			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr4:90830461delC	ENST00000394980.1	+	3	977	c.658delC	c.(658-660)ccfs	p.P220fs	MMRN1_ENST00000264790.2_Frame_Shift_Del_p.P220fs|MMRN1_ENST00000394981.1_Frame_Shift_Del_p.P186fs|MMRN1_ENST00000508372.1_5'UTR			Q13201	MMRN1_HUMAN	multimerin 1	220	EMI.				cell adhesion|platelet activation|platelet degranulation	extracellular region|platelet alpha granule lumen				breast(2)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(12)|liver(2)|lung(34)|ovary(5)|prostate(1)|skin(6)|stomach(1)|urinary_tract(2)	72		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;6.96e-05)		CAGGTTATCTCCCACAGTGAT	0.398													14	54	---	---	---	---					
HTR1E	3354	broad.mit.edu	37	6	87725434	87725434	+	Frame_Shift_Del	DEL	A	A	-			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr6:87725434delA	ENST00000305344.4	+	2	1085	c.382delA	c.(382-384)ttfs	p.I128fs	HTR1E_ENST00000369584.1_Frame_Shift_Del_p.I128fs	NM_000865.2	NP_000856.1	P28566	5HT1E_HUMAN	5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled	128					G-protein signaling, coupled to cyclic nucleotide second messenger|synaptic transmission	integral to plasma membrane	protein binding|serotonin binding|serotonin receptor activity			breast(3)|endometrium(2)|kidney(3)|large_intestine(11)|lung(15)|ovary(2)|prostate(2)|skin(3)	41		all_cancers(76;7.11e-06)|Acute lymphoblastic leukemia(125;1.2e-09)|Prostate(29;3.51e-09)|all_hematologic(105;7.43e-06)|all_epithelial(107;0.00819)		BRCA - Breast invasive adenocarcinoma(108;0.055)	Eletriptan(DB00216)	CACCAATGCTATTGAATACGC	0.567													17	108	---	---	---	---					
THSD7A	221981	broad.mit.edu	37	7	11633068	11633068	+	Frame_Shift_Del	DEL	G	G	-			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr7:11633068delG	ENST00000423059.3	-	3	1335	c.1084delC	c.(1084-1086)agfs	p.Q362fs		NM_015204.2	NP_056019.1	Q9UPZ6	THS7A_HUMAN	thrombospondin, type I, domain containing 7A	362	TSP type-1 3.					integral to membrane				NS(1)|autonomic_ganglia(1)|breast(5)|cervix(1)|endometrium(8)|kidney(2)|large_intestine(7)|lung(68)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(11)	113				UCEC - Uterine corpus endometrioid carcinoma (126;0.163)		TCGGAAACCTGGCACTCTTTG	0.498										HNSCC(18;0.044)			35	64	---	---	---	---					
CSMD1	64478	broad.mit.edu	37	8	3047596	3047596	+	Frame_Shift_Del	DEL	C	C	-			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr8:3047596delC	ENST00000520002.1	-	35	5794	c.5239delG	c.(5239-5241)agfs	p.E1747fs	CSMD1_ENST00000537824.1_Frame_Shift_Del_p.E1746fs|CSMD1_ENST00000523387.1_5'UTR|CSMD1_ENST00000602723.1_Frame_Shift_Del_p.E1747fs|CSMD1_ENST00000400186.3_Frame_Shift_Del_p.E1747fs|CSMD1_ENST00000602557.1_Frame_Shift_Del_p.E1747fs|CSMD1_ENST00000542608.1_Frame_Shift_Del_p.E1746fs|CSMD1_ENST00000539096.1_Frame_Shift_Del_p.E1746fs			Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1	1747	Sushi 10.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		TATCTGGGCTCGGGGACAGAG	0.557													5	4	---	---	---	---					
KCNV1	27012	broad.mit.edu	37	8	110980335	110980336	+	Frame_Shift_Ins	INS	-	-	C			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr8:110980335_110980336insC	ENST00000524391.1	-	4	2516_2517	c.1484_1485insG	c.(1483-1485)ggafs	p.G495fs	KCNV1_ENST00000297404.1_Frame_Shift_Ins_p.G495fs			Q6PIU1	KCNV1_HUMAN	potassium channel, subfamily V, member 1	495						voltage-gated potassium channel complex	ion channel inhibitor activity|potassium channel regulator activity|voltage-gated potassium channel activity			breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(20)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	37	all_neural(195;0.219)		OV - Ovarian serous cystadenocarcinoma(57;5.35e-13)			AGAAATCATCTCCCCCGCTGCT	0.371													11	40	---	---	---	---					
PRKCQ	5588	broad.mit.edu	37	10	6553114	6553114	+	Frame_Shift_Del	DEL	G	G	-			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr10:6553114delG	ENST00000263125.5	-	3	260	c.161delC	c.(160-162)cafs	p.P55fs	PRKCQ_ENST00000539722.1_5'UTR|PRKCQ_ENST00000397176.2_Frame_Shift_Del_p.P55fs	NM_006257.3	NP_006248.1	Q04759	KPCT_HUMAN	protein kinase C, theta	55	C2.				axon guidance|cellular component disassembly involved in apoptosis|intracellular signal transduction|membrane protein ectodomain proteolysis|platelet activation|regulation of cell growth|T cell receptor signaling pathway	cytosol	ATP binding|metal ion binding|protein binding|protein kinase C activity			NS(1)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|liver(1)|lung(13)|ovary(4)|prostate(1)|skin(4)|stomach(2)	45						GTCCCAGGGTGGGTACATGGT	0.458													13	109	---	---	---	---					
KIF18A	81930	broad.mit.edu	37	11	28119344	28119346	+	In_Frame_Del	DEL	CTT	CTT	-			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr11:28119344_28119346delCTT	ENST00000263181.6	-	2	439_441	c.149_151delAAG	c.(148-153)gtc>g	p.EV50del		NM_031217.3	NP_112494.3	Q8NI77	KI18A_HUMAN	kinesin family member 18A	50	Kinesin-motor.				blood coagulation|microtubule depolymerization|microtubule-based movement|mitotic metaphase plate congression|mitotic prometaphase|protein transport	caveola|cytosol|kinetochore microtubule|microtubule organizing center|nucleus|ruffle	actin binding|ATP binding|microtubule plus-end binding|plus-end-directed microtubule motor activity|tubulin-dependent ATPase activity|ubiquitin binding			breast(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(10)|ovary(3)|prostate(1)|skin(1)|urinary_tract(2)	36						AAAAAACTGACTTCTTCTTGTTT	0.320													9	70	---	---	---	---					
OR4X2	119764	broad.mit.edu	37	11	48266864	48266864	+	Frame_Shift_Del	DEL	C	C	-			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr11:48266864delC	ENST00000302329.3	+	1	257	c.209delC	c.(208-210)gcfs	p.A70fs		NM_001004727.1	NP_001004727.1	Q8NGF9	OR4X2_HUMAN	olfactory receptor, family 4, subfamily X, member 2	70					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|large_intestine(4)|lung(12)|pancreas(1)|stomach(1)|upper_aerodigestive_tract(1)	20						TCCGCTACAGCCCCCAAACTC	0.512													17	128	---	---	---	---					
PICALM	8301	broad.mit.edu	37	11	85712167	85712167	+	Frame_Shift_Del	DEL	C	C	-			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr11:85712167delC	ENST00000526033.1	-	10	1244	c.928delG	c.(928-930)cafs	p.A310fs	PICALM_ENST00000528398.1_Frame_Shift_Del_p.A259fs|PICALM_ENST00000393346.3_Frame_Shift_Del_p.A310fs|PICALM_ENST00000356360.5_Frame_Shift_Del_p.A310fs|PICALM_ENST00000532317.1_Frame_Shift_Del_p.A310fs	NM_001206946.1|NM_007166.3	NP_001193875.1|NP_009097.2	Q13492	PICAL_HUMAN	phosphatidylinositol binding clathrin assembly protein	310					clathrin coat assembly|endosome transport|negative regulation of receptor-mediated endocytosis|positive regulation of transcription, DNA-dependent|receptor internalization|regulation of protein localization	clathrin coat|clathrin-coated vesicle|coated pit|Golgi apparatus|nucleus|postsynaptic membrane|presynaptic membrane	1-phosphatidylinositol binding|clathrin heavy chain binding			endometrium(1)|kidney(2)|large_intestine(2)|liver(1)|lung(10)|ovary(1)|skin(1)|urinary_tract(1)	19		Acute lymphoblastic leukemia(157;7.42e-07)|all_hematologic(158;0.00092)				CCAGTGCTTGCCAGGGAAGAC	0.428			T	"""MLLT10, MLL"""	"""TALL, AML, """								23	109	---	---	---	---					
CNTN5	53942	broad.mit.edu	37	11	100211204	100211204	+	Frame_Shift_Del	DEL	T	T	-			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr11:100211204delT	ENST00000524871.1	+	22	3030	c.2740delT	c.(2740-2742)ggfs	p.W914fs	CNTN5_ENST00000528682.1_Frame_Shift_Del_p.W914fs|CNTN5_ENST00000418526.2_Frame_Shift_Del_p.W840fs|CNTN5_ENST00000524560.1_3'UTR|CNTN5_ENST00000279463.3_Frame_Shift_Del_p.W914fs	NM_014361.3	NP_055176.1	O94779	CNTN5_HUMAN	contactin 5	914	Fibronectin type-III 3.				cell adhesion	anchored to membrane|plasma membrane	protein binding			NS(2)|breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(12)|lung(38)|ovary(2)|pancreas(2)|prostate(2)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(1)	81		all_hematologic(158;1.22e-05)|Acute lymphoblastic leukemia(157;3.81e-05)|Melanoma(852;0.219)		BRCA - Breast invasive adenocarcinoma(274;0.00146)|KIRC - Kidney renal clear cell carcinoma(183;0.156)|Kidney(183;0.196)		GGTTGGTTACTGGAAAGACAT	0.383													12	13	---	---	---	---					
HTR3A	3359	broad.mit.edu	37	11	113856784	113856785	+	Frame_Shift_Ins	INS	-	-	C			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr11:113856784_113856785insC	ENST00000504030.2	+	6	1037_1038	c.592_593insC	c.(592-594)cgafs	p.R198fs	HTR3A_ENST00000535865.1_Intron|HTR3A_ENST00000355556.2_Frame_Shift_Ins_p.R204fs|HTR3A_ENST00000506841.2_Frame_Shift_Ins_p.R198fs|HTR3A_ENST00000299961.5_Frame_Shift_Ins_p.R183fs|HTR3A_ENST00000375498.2_Frame_Shift_Ins_p.R204fs			P46098	5HT3A_HUMAN	5-hydroxytryptamine (serotonin) receptor 3A, ionotropic	198					digestion|synaptic transmission	cell junction|integral to plasma membrane|postsynaptic membrane	serotonin binding|serotonin receptor activity|serotonin-activated cation-selective channel activity			central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(14)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)	36		all_cancers(61;2.31e-17)|all_epithelial(67;2.1e-10)|all_hematologic(158;4.64e-05)|Melanoma(852;0.000312)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0101)|all_neural(223;0.0281)|Prostate(24;0.0294)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;2.71e-06)|Epithelial(105;2.58e-05)|all cancers(92;0.000238)|OV - Ovarian serous cystadenocarcinoma(223;0.191)	Alosetron(DB00969)|Chloroprocaine(DB01161)|Cisapride(DB00604)|Dolasetron(DB00757)|Granisetron(DB00889)|Mirtazapine(DB00370)|Ondansetron(DB00904)|Palonosetron(DB00377)|Procaine(DB00721)|Tubocurarine(DB01199)	AAAGGTGAAATCCGACAGGAGT	0.505													88	211	---	---	---	---					
CCDC91	55297	broad.mit.edu	37	12	28458733	28458734	+	Frame_Shift_Ins	INS	-	-	T			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr12:28458733_28458734insT	ENST00000545336.1	+	7	680_681	c.261_262insT	c.(259-264)aacacafs	p.T88fs	CCDC91_ENST00000381256.1_Frame_Shift_Ins_p.T88fs|CCDC91_ENST00000306172.5_Frame_Shift_Ins_p.T58fs|CCDC91_ENST00000381259.1_Frame_Shift_Ins_p.T88fs|CCDC91_ENST00000539107.1_Frame_Shift_Ins_p.T88fs|CCDC91_ENST00000540401.1_3'UTR			Q7Z6B0	CCD91_HUMAN	coiled-coil domain containing 91	88					protein transport	Golgi apparatus|membrane				NS(1)|breast(3)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(8)|skin(1)	22	Acute lymphoblastic leukemia(23;0.00718)|all_hematologic(23;0.0113)|Lung SC(9;0.184)					CTATTCCAAAAGCACAGGTAAA	0.332													32	110	---	---	---	---					
LATS2	26524	broad.mit.edu	37	13	21562482	21562483	+	In_Frame_Ins	INS	-	-	GGGGCG	rs56252009		TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr13:21562482_21562483insGGGGCG	ENST00000382592.4	-	4	1841_1842	c.1436_1437insCGCCCC	c.(1435-1437)cgc>cCGCCCCgc	p.478_479insPP	LATS2_ENST00000542899.1_In_Frame_Ins_p.478_479insPP	NM_014572.2	NP_055387.2	Q9NRM7	LATS2_HUMAN	large tumor suppressor kinase 2	478					cell division|G1/S transition of mitotic cell cycle|hippo signaling cascade|hormone-mediated signaling pathway|intracellular protein kinase cascade|mitosis|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cyclin-dependent protein kinase activity	microtubule organizing center|nucleus|spindle pole	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity	p.P473_A480delPAPAPAPA(2)|p.P479_A480insGR(1)		breast(4)|central_nervous_system(3)|endometrium(2)|kidney(2)|large_intestine(7)|lung(19)|ovary(3)|pancreas(1)|prostate(2)|urinary_tract(2)	45		all_cancers(29;4.74e-22)|all_epithelial(30;1.45e-18)|all_lung(29;4.69e-16)|Lung SC(185;0.0262)|Hepatocellular(188;0.244)		all cancers(112;0.000781)|Epithelial(112;0.00144)|OV - Ovarian serous cystadenocarcinoma(117;0.0183)|Lung(94;0.0375)|LUSC - Lung squamous cell carcinoma(192;0.104)		CCTCCGCAgccggggcgggggc	0.787													2	4	---	---	---	---					
HERC2P2	400322	broad.mit.edu	37	15	23285254	23285258	+	RNA	DEL	TCCCT	TCCCT	-			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr15:23285254_23285258delTCCCT	ENST00000560464.1	-	0	5097																											CTTTCTTCTCtcccttcccttccct	0.478													3	4	---	---	---	---					
DISP2	85455	broad.mit.edu	37	15	40659416	40659421	+	In_Frame_Del	DEL	TTCGGA	TTCGGA	-			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr15:40659416_40659421delTTCGGA	ENST00000267889.3	+	8	1190_1195	c.1103_1108delTTCGGA	c.(1102-1110)ccc>c	p.LRT368del		NM_033510.1	NP_277045.1	A7MBM2	DISP2_HUMAN	dispatched homolog 2 (Drosophila)	368					smoothened signaling pathway	integral to membrane				breast(1)|endometrium(4)|kidney(2)|large_intestine(7)|lung(12)|ovary(4)	30		all_cancers(109;9.35e-19)|all_epithelial(112;1.18e-15)|Lung NSC(122;2.45e-11)|all_lung(180;6.47e-10)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;3.39e-06)|Colorectal(105;0.0114)|READ - Rectum adenocarcinoma(2;0.0649)|BRCA - Breast invasive adenocarcinoma(123;0.0798)|Lung(196;0.15)|LUAD - Lung adenocarcinoma(183;0.247)		CTGGCCCTGCTTCGGACCTGTGCCCT	0.641													29	165	---	---	---	---					
EHD4	30844	broad.mit.edu	37	15	42193197	42193197	+	Frame_Shift_Del	DEL	G	G	-			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr15:42193197delG	ENST00000220325.4	-	6	1355	c.1272delC	c.(1270-1272)ccfs	p.P424fs		NM_139265.3	NP_644670.1	Q9H223	EHD4_HUMAN	EH-domain containing 4	424				TEGPFNQGYGEGA -> PRAPSTRATGRVP (in Ref. 2).	endocytic recycling|protein homooligomerization	early endosome membrane|endoplasmic reticulum|nucleus|recycling endosome membrane	ATP binding|calcium ion binding|GTP binding|GTPase activity|nucleic acid binding|protein binding			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(7)|ovary(2)|stomach(1)|urinary_tract(1)	20		all_cancers(109;2.54e-12)|all_epithelial(112;6.59e-11)|Lung NSC(122;2.17e-07)|all_lung(180;8.79e-07)|Melanoma(134;0.091)		OV - Ovarian serous cystadenocarcinoma(18;1.6e-19)|GBM - Glioblastoma multiforme(94;3.77e-06)|COAD - Colon adenocarcinoma(120;0.0474)|Colorectal(105;0.0538)		CCTGGTTGAAGGGGCCCTCGG	0.652													10	49	---	---	---	---					
SERPINB11	89778	broad.mit.edu	37	18	61388270	61388271	+	RNA	DEL	AC	AC	-			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr18:61388270_61388271delAC	ENST00000544088.1	+	0	836				SERPINB11_ENST00000382749.5_RNA|SERPINB11_ENST00000536691.1_RNA|SERPINB11_ENST00000538847.1_RNA	NM_080475.2	NP_536723.2	Q96P15	SPB11_HUMAN	serpin peptidase inhibitor, clade B (ovalbumin), member 11 (gene/pseudogene)						regulation of proteolysis	cytoplasm	serine-type endopeptidase inhibitor activity			breast(1)|cervix(1)|kidney(1)|lung(3)	6		Esophageal squamous(42;0.129)				GTGCATGTTAACACACACACAC	0.386													2	4	---	---	---	---					
LPHN1	22859	broad.mit.edu	37	19	14273672	14273685	+	Frame_Shift_Del	DEL	AAGGCGTTGGATGC	AAGGCGTTGGATGC	-			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr19:14273672_14273685delAAGGCGTTGGATGC	ENST00000340736.6	-	6	1240_1253	c.943_956delGCATCCAACGCCTT	c.(943-957)cfs	p.ASNAF315fs	LPHN1_ENST00000361434.3_Frame_Shift_Del_p.ASNAF310fs|CTB-55O6.12_ENST00000592086.1_RNA|CTB-55O6.12_ENST00000588387.1_RNA	NM_001008701.2	NP_001008701.1	O94910	LPHN1_HUMAN	latrophilin 1	315	Olfactomedin-like.				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|sugar binding			central_nervous_system(1)|cervix(2)|endometrium(6)|kidney(1)|large_intestine(3)|liver(1)|lung(10)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	32						ACACACCATGAAGGCGTTGGATGCCGAGCGCTTG	0.621													17	33	---	---	---	---					
ZNF529	57711	broad.mit.edu	37	19	37038878	37038879	+	Frame_Shift_Ins	INS	-	-	GT			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr19:37038878_37038879insGT	ENST00000334116.7	-	6	876_877	c.266_267insAC	c.(265-267)aggfs	p.R89fs	ZNF529_ENST00000591340.1_Frame_Shift_Ins_p.R194fs	NM_001145650.1	NP_001139122.1	Q6P280	ZN529_HUMAN	zinc finger protein 529	161					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)	1	Esophageal squamous(110;0.198)					TTTTTCCACCAGTATGTATTTT	0.361													25	29	---	---	---	---					
ACTR5	79913	broad.mit.edu	37	20	37383728	37383728	+	Frame_Shift_Del	DEL	T	T	-			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chr20:37383728delT	ENST00000243903.4	+	4	941	c.904delT	c.(904-906)tgfs	p.L302fs		NM_024855.3	NP_079131.3	Q9H9F9	ARP5_HUMAN	ARP5 actin-related protein 5 homolog (yeast)	302					DNA recombination|double-strand break repair|regulation of transcription, DNA-dependent|transcription, DNA-dependent|UV-damage excision repair	cytoplasm|Ino80 complex	ATP binding|protein binding			kidney(2)|large_intestine(2)|liver(1)|lung(5)|skin(2)	12		Myeloproliferative disorder(115;0.00878)				GCAGCAGCAATTGCGGCGGCT	0.557													30	52	---	---	---	---					
AMER1	139285	broad.mit.edu	37	X	63412445	63412445	+	Frame_Shift_Del	DEL	G	G	-			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chrX:63412445delG	ENST00000330258.3	-	2	994	c.722delC	c.(721-723)cafs	p.P241fs	AMER1_ENST00000374869.3_Frame_Shift_Del_p.P241fs|AMER1_ENST00000403336.1_Frame_Shift_Del_p.P241fs	NM_152424.3	NP_689637.3			APC membrane recruitment protein 1									p.0?(67)									TTCTGGTGTTGGAGAAACTTT	0.537													52	81	---	---	---	---					
FTX	100302692	broad.mit.edu	37	X	73506653	73506654	+	RNA	INS	-	-	A	rs149262205		TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chrX:73506653_73506654insA	ENST00000429124.1	-	0	174																											acctgtcccttaaaaaaaaaaa	0.455													4	4	---	---	---	---					
UTP14A	10813	broad.mit.edu	37	X	129060248	129060248	+	Frame_Shift_Del	DEL	G	G	-			TCGA-78-8640-01A-11D-2393-08	TCGA-78-8640-11A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c50986c8-b096-4ca6-9afe-ad02977329cb	dc97ac53-1ebd-4ba6-a5ee-d39aabcd2b11	g.chrX:129060248delG	ENST00000394422.3	+	14	2004	c.1976delG	c.(1975-1977)aafs	p.R659fs	UTP14A_ENST00000371051.5_Frame_Shift_Del_p.R605fs|UTP14A_ENST00000371042.3_Frame_Shift_Del_p.R491fs|RP4-537K23.4_ENST00000432062.1_RNA|UTP14A_ENST00000425117.2_Frame_Shift_Del_p.R607fs	NM_006649.3	NP_006640.2	Q9BVJ6	UT14A_HUMAN	UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)	659					rRNA processing	nucleolus|small-subunit processome	protein binding			breast(1)|endometrium(1)|kidney(2)|large_intestine(6)|liver(2)|lung(16)|ovary(3)|urinary_tract(1)	32						GGTCCTCCAAGAAAAGATAAG	0.458											OREG0019920	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	15	57	---	---	---	---