Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
SPTB	6710	broad.mit.edu	37	14	65268073	65268073	+	Silent	SNP	C	C	T			TCGA-75-6212-01A-11D-1753-08	TCGA-75-6212-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0f2af4c9-05a8-4c97-ac2d-af9241b4ea64	20817c66-3be1-4450-8be9-a922838cec1f	g.chr14:65268073C>T	ENST00000389722.3	-	6	746	c.693G>A	c.(691-693)cgG>cgA	p.R231R	SPTB_ENST00000542895.1_Silent_p.R231R|SPTB_ENST00000389721.5_Silent_p.R231R|SPTB_ENST00000556626.1_Silent_p.R231R|SPTB_ENST00000389720.3_Silent_p.R231R	NM_001024858.2	NP_001020029.1	P11277	SPTB1_HUMAN	spectrin, beta, erythrocytic	231	Actin-binding.|CH 2.				actin filament capping|axon guidance	cell surface|cytosol|intrinsic to internal side of plasma membrane|protein complex|spectrin|spectrin-associated cytoskeleton	actin filament binding|structural constituent of cytoskeleton	p.R231R(1)		breast(5)|central_nervous_system(4)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|lung(36)|ovary(8)|pancreas(1)|prostate(4)|skin(10)|urinary_tract(3)	106		all_lung(585;4.15e-09)		all cancers(60;4.33e-34)|OV - Ovarian serous cystadenocarcinoma(108;8.32e-20)|BRCA - Breast invasive adenocarcinoma(234;0.0628)		CCAGGTTGTGCCGGGCATTGG	0.602000											OREG0022735	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	3	52					0	0	0.004672	0	0
IGHA2	3494	broad.mit.edu	37	14	106054658	106054658	+	RNA	SNP	T	T	G	rs114771275	by1000genomes	TCGA-75-6212-01A-11D-1753-08	TCGA-75-6212-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0f2af4c9-05a8-4c97-ac2d-af9241b4ea64	20817c66-3be1-4450-8be9-a922838cec1f	g.chr14:106054658T>G	ENST00000390539.2	-	0	74																											GGACCAGGCATGCGACGACCA	0.622000													3	68					0	0	0.014758	0	0
L1CAM	3897	broad.mit.edu	37	X	153132164	153132164	+	Missense_Mutation	SNP	C	C	T			TCGA-75-6212-01A-11D-1753-08	TCGA-75-6212-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0f2af4c9-05a8-4c97-ac2d-af9241b4ea64	20817c66-3be1-4450-8be9-a922838cec1f	g.chrX:153132164C>T	ENST00000370060.1	-	19	2560	c.2371G>A	c.(2371-2373)Gtc>Atc	p.V791I	L1CAM_ENST00000543994.1_Missense_Mutation_p.V793I|L1CAM_ENST00000538883.1_Missense_Mutation_p.V793I|L1CAM_ENST00000370055.1_Missense_Mutation_p.V786I|L1CAM_ENST00000370057.3_Missense_Mutation_p.V791I|L1CAM_ENST00000361699.4_Missense_Mutation_p.V791I|L1CAM_ENST00000361981.3_Missense_Mutation_p.V786I	NM_001278116.1	NP_001265045.1	P32004	L1CAM_HUMAN	L1 cell adhesion molecule	791	Fibronectin type-III 2.				axon guidance|blood coagulation|cell death|leukocyte migration	integral to membrane		p.V791I(1)		NS(1)|breast(4)|central_nervous_system(3)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(5)|liver(1)|lung(31)|ovary(13)|pancreas(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	81	all_cancers(53;6.72e-15)|all_epithelial(53;3.19e-09)|all_lung(58;3.39e-06)|all_hematologic(71;4.25e-06)|Lung NSC(58;4.7e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					TGGCTGTTGACGGCCTGGACT	0.632000													10	79					0	0	0.069234	0	0
SCML4	256380	broad.mit.edu	37	6	108042097	108042097	+	Missense_Mutation	SNP	C	C	A			TCGA-75-6212-01A-11D-1753-08	TCGA-75-6212-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0f2af4c9-05a8-4c97-ac2d-af9241b4ea64	20817c66-3be1-4450-8be9-a922838cec1f	g.chr6:108042097C>A	ENST00000369022.2	-	5	818	c.609G>T	c.(607-609)ttG>ttT	p.L203F	SCML4_ENST00000369025.2_Missense_Mutation_p.L19F|SCML4_ENST00000479803.1_5'UTR|SCML4_ENST00000369021.3_Missense_Mutation_p.L232F|SCML4_ENST00000369020.3_Missense_Mutation_p.L261F			Q8N228	SCML4_HUMAN	sex comb on midleg-like 4 (Drosophila)	261					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding	p.L232F(2)|p.L261F(2)		endometrium(2)|large_intestine(7)|lung(11)|ovary(3)|prostate(1)|skin(1)	25		all_cancers(87;3.26e-06)|Acute lymphoblastic leukemia(125;3.08e-08)|all_hematologic(75;1.15e-06)|all_epithelial(87;0.00142)|Colorectal(196;0.0316)		BRCA - Breast invasive adenocarcinoma(108;0.01)|Epithelial(106;0.0509)|all cancers(137;0.0586)|OV - Ovarian serous cystadenocarcinoma(136;0.0758)		AGGAGGGGTGCAAGGAGCCCC	0.622000													12	64					0.00010058	0.000113475	0.093190	1	0
OBSCN	84033	broad.mit.edu	37	1	228459865	228459865	+	Missense_Mutation	SNP	G	G	A			TCGA-75-6212-01A-11D-1753-08	TCGA-75-6212-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0f2af4c9-05a8-4c97-ac2d-af9241b4ea64	20817c66-3be1-4450-8be9-a922838cec1f	g.chr1:228459865G>A	ENST00000570156.2	+	20	6003	c.5929G>A	c.(5929-5931)Ggg>Agg	p.G1977R	OBSCN_ENST00000284548.11_Intron|OBSCN_ENST00000422127.1_Intron|RP5-1139B12.2_ENST00000602517.1_RNA|OBSCN_ENST00000366707.4_Intron|OBSCN_ENST00000359599.6_Missense_Mutation_p.G449R|OBSCN_ENST00000366709.4_Intron	NM_001271223.2	NP_001258152.2	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	958	Ig-like 19.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding	p.G1885R(1)		NS(2)|breast(7)|central_nervous_system(5)|cervix(2)|endometrium(30)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(37)|lung(89)|ovary(8)|pancreas(3)|prostate(13)|skin(6)|stomach(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	223		Prostate(94;0.0405)				GGCGGACGCCGGGGAGTACAG	0.647000													5	35					0	0	0.014758	0	0
SP140L	93349	broad.mit.edu	37	2	231222646	231222646	+	Silent	SNP	C	C	T			TCGA-75-6212-01A-11D-1753-08	TCGA-75-6212-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0f2af4c9-05a8-4c97-ac2d-af9241b4ea64	20817c66-3be1-4450-8be9-a922838cec1f	g.chr2:231222646C>T	ENST00000243810.6	+	3	234	c.234C>T	c.(232-234)ctC>ctT	p.L78L	SP140L_ENST00000396563.4_Silent_p.L78L|SP140_ENST00000486687.2_3'UTR|SP140L_ENST00000444636.1_Silent_p.L78L|SP140L_ENST00000415673.2_Silent_p.L78L|SP140L_ENST00000458341.1_5'UTR			Q9H930	LY10L_HUMAN	SP140 nuclear body protein-like	78	HSR.					nucleus	DNA binding|metal ion binding	p.L78L(2)		central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(5)|lung(7)|prostate(1)|skin(1)	20						TTGAGGGCCTCCGCGATCGGG	0.358000													36	224					0	0	0.104719	0	0
TBL1X	6907	broad.mit.edu	37	X	9661224	9661224	+	Silent	SNP	C	C	T	rs142039049		TCGA-75-6212-01A-11D-1753-08	TCGA-75-6212-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0f2af4c9-05a8-4c97-ac2d-af9241b4ea64	20817c66-3be1-4450-8be9-a922838cec1f	g.chrX:9661224C>T	ENST00000217964.7	+	10	1567	c.927C>T	c.(925-927)gaC>gaT	p.D309D	TBL1X_ENST00000536365.1_Silent_p.D258D|TBL1X_ENST00000407597.2_Silent_p.D309D|TBL1X_ENST00000380961.1_Silent_p.D258D|TBL1X_ENST00000424279.1_Silent_p.D258D	NM_005647.3	NP_005638.1	O60907	TBL1X_HUMAN	transducin (beta)-like 1X-linked	309					canonical Wnt receptor signaling pathway|cellular lipid metabolic process|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|proteasomal ubiquitin-dependent protein catabolic process|sensory perception of sound|transcription, DNA-dependent	spindle microtubule|transcriptional repressor complex	beta-catenin binding|histone binding|protein C-terminus binding|protein domain specific binding|transcription corepressor activity|transcription factor binding|transcription regulatory region DNA binding	p.D309D(2)		breast(2)|cervix(1)|endometrium(5)|large_intestine(7)|lung(2)|ovary(1)|skin(2)	20		Hepatocellular(5;0.000888)				GTTCATATGACGGTTTTGCAA	0.522000													15	103					0	0	0.038395	0	0
PHF21B	112885	broad.mit.edu	37	22	45309828	45309828	+	Silent	SNP	C	C	T			TCGA-75-6212-01A-11D-1753-08	TCGA-75-6212-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0f2af4c9-05a8-4c97-ac2d-af9241b4ea64	20817c66-3be1-4450-8be9-a922838cec1f	g.chr22:45309828C>T	ENST00000313237.5	-	5	855	c.705G>A	c.(703-705)caG>caA	p.Q235Q	PHF21B_ENST00000396103.3_Silent_p.Q193Q|PHF21B_ENST00000404079.2_Silent_p.Q181Q|PHF21B_ENST00000403565.1_Silent_p.Q31Q|PHF21B_ENST00000447824.3_Silent_p.Q181Q	NM_138415.4	NP_612424.1	Q96EK2	PF21B_HUMAN	PHD finger protein 21B	235							zinc ion binding	p.Q235Q(1)		breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(14)|ovary(2)|prostate(1)|skin(2)	25		all_neural(38;0.00802)|Glioma(61;0.0353)|Ovarian(80;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0203)		GCACTTGAGGCTGAATGATGA	0.612000													17	95					0	0	0.049695	0	0
CYP4F8	11283	broad.mit.edu	37	19	15729054	15729054	+	RNA	SNP	C	C	T			TCGA-75-6212-01A-11D-1753-08	TCGA-75-6212-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0f2af4c9-05a8-4c97-ac2d-af9241b4ea64	20817c66-3be1-4450-8be9-a922838cec1f	g.chr19:15729054C>T	ENST00000441682.2	+	0	407							P98187	CP4F8_HUMAN	cytochrome P450, family 4, subfamily F, polypeptide 8						prostaglandin metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	alkane 1-monooxygenase activity|aromatase activity|electron carrier activity|heme binding|oxygen binding|protein binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(14)|skin(1)	26						AGTACTCAGCCCCTTCCTTCC	0.537000													3	31					0	0	0.004672	0	0
MRPL39	54148	broad.mit.edu	37	21	26965143	26965143	+	Missense_Mutation	SNP	G	G	A			TCGA-75-6212-01A-11D-1753-08	TCGA-75-6212-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0f2af4c9-05a8-4c97-ac2d-af9241b4ea64	20817c66-3be1-4450-8be9-a922838cec1f	g.chr21:26965143G>A	ENST00000307301.7	-	8	943	c.902C>T	c.(901-903)tCt>tTt	p.S301F	MRPL39_ENST00000352957.4_Missense_Mutation_p.S301F	NM_080794.3	NP_542984.2	Q9NYK5	RM39_HUMAN	mitochondrial ribosomal protein L39	301						mitochondrial ribosome	nucleotide binding	p.S301F(2)		endometrium(2)|large_intestine(3)|lung(4)|ovary(1)	10						AACAGGTAAAGACACGCCCTG	0.378000													13	54					0	0	0.055883	0	0
TGFBR3	7049	broad.mit.edu	37	1	92177890	92177890	+	Missense_Mutation	SNP	G	G	T			TCGA-75-6212-01A-11D-1753-08	TCGA-75-6212-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0f2af4c9-05a8-4c97-ac2d-af9241b4ea64	20817c66-3be1-4450-8be9-a922838cec1f	g.chr1:92177890G>T	ENST00000212355.4	-	13	2541	c.2076C>A	c.(2074-2076)ttC>ttA	p.F692L	TGFBR3_ENST00000370399.2_Missense_Mutation_p.F691L|TGFBR3_ENST00000525962.1_Missense_Mutation_p.F692L	NM_001195683.1|NM_003243.4	NP_001182612.1|NP_003234.2	Q03167	TGBR3_HUMAN	transforming growth factor, beta receptor III	692	ZP.				BMP signaling pathway|cardiac epithelial to mesenchymal transition|cardiac muscle cell proliferation|cell growth|cell migration|definitive erythrocyte differentiation|heart trabecula formation|immune response|intracellular protein kinase cascade|liver development|negative regulation of cellular component movement|negative regulation of epithelial cell proliferation|palate development|pathway-restricted SMAD protein phosphorylation|response to follicle-stimulating hormone stimulus|response to luteinizing hormone stimulus|response to prostaglandin E stimulus|transforming growth factor beta receptor signaling pathway|ventricular cardiac muscle tissue morphogenesis	external side of plasma membrane|extracellular space|inhibin-betaglycan-ActRII complex|integral to plasma membrane|intracellular membrane-bounded organelle	coreceptor activity|heparin binding|PDZ domain binding|SMAD binding|transforming growth factor beta binding|transforming growth factor beta receptor activity, type III|type II transforming growth factor beta receptor binding	p.F692L(1)		endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(24)|ovary(3)|prostate(4)|skin(1)|stomach(1)|urinary_tract(3)	55		all_lung(203;0.00719)|Lung NSC(277;0.0268)		all cancers(265;0.0108)|Epithelial(280;0.0825)		AGACAGGCTTGAAGACAAAGC	0.473000													8	67					7.48243e-07	8.66386e-07	0.058154	1	0
SSTR4	6754	broad.mit.edu	37	20	23016703	23016703	+	Missense_Mutation	SNP	G	G	A			TCGA-75-6212-01A-11D-1753-08	TCGA-75-6212-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0f2af4c9-05a8-4c97-ac2d-af9241b4ea64	20817c66-3be1-4450-8be9-a922838cec1f	g.chr20:23016703G>A	ENST00000255008.3	+	1	647	c.583G>A	c.(583-585)Gcc>Acc	p.A195T	RP4-753D10.3_ENST00000440921.1_RNA	NM_001052.2	NP_001043.2	P31391	SSR4_HUMAN	somatostatin receptor 4	195					G-protein signaling, coupled to cyclic nucleotide second messenger|negative regulation of cell proliferation	integral to plasma membrane	somatostatin receptor activity	p.A195T(1)		breast(1)|central_nervous_system(2)|endometrium(6)|kidney(1)|large_intestine(4)|lung(16)|ovary(1)|upper_aerodigestive_tract(1)	32	Colorectal(13;0.0518)|Lung NSC(19;0.0542)|all_lung(19;0.118)					CGGCGGCCAGGCCGTGGCCTG	0.662000													9	30					0	0	0.105934	0	0
FGA	2243	broad.mit.edu	37	4	155508070	155508070	+	Splice_Site	SNP	C	C	T			TCGA-75-6212-01A-11D-1753-08	TCGA-75-6212-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0f2af4c9-05a8-4c97-ac2d-af9241b4ea64	20817c66-3be1-4450-8be9-a922838cec1f	g.chr4:155508070C>T	ENST00000302053.3	-	5	589	c.510_splice	c.e5-1	p.V171_splice	FGA_ENST00000403106.3_Splice_Site_p.V171_splice	NM_000508.3	NP_000499.1	P02671	FIBA_HUMAN	fibrinogen alpha chain	171					platelet activation|platelet degranulation|protein polymerization|response to calcium ion|signal transduction	external side of plasma membrane|fibrinogen complex|platelet alpha granule lumen	eukaryotic cell surface binding|protein binding, bridging|receptor binding	p.V171M(1)		NS(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(14)|liver(2)|lung(20)|ovary(3)|pancreas(1)|prostate(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(6)	73	all_hematologic(180;0.215)	Renal(120;0.0458)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Sucralfate(DB00364)|Tenecteplase(DB00031)	TCAATGTCCACCTAGAGAGAG	0.393000													14	49					0	0	0.024245	0	0
PCDHB3	56132	broad.mit.edu	37	5	140482147	140482147	+	Missense_Mutation	SNP	C	C	G	rs144773246	byFrequency	TCGA-75-6212-01A-11D-1753-08	TCGA-75-6212-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0f2af4c9-05a8-4c97-ac2d-af9241b4ea64	20817c66-3be1-4450-8be9-a922838cec1f	g.chr5:140482147C>G	ENST00000231130.2	+	1	1914	c.1914C>G	c.(1912-1914)caC>caG	p.H638Q		NM_018937.2	NP_061760.1	Q9Y5E6	PCDB3_HUMAN		638	Cadherin 6.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding	p.H638Q(1)		NS(2)|breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(19)|lung(24)|ovary(1)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	72			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CGGCCAAGCACAGGCTGGTGG	0.697000													3	49					0	0	0.004672	0	0
TICRR	90381	broad.mit.edu	37	15	90167027	90167027	+	Silent	SNP	A	A	C			TCGA-75-6212-01A-11D-1753-08	TCGA-75-6212-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0f2af4c9-05a8-4c97-ac2d-af9241b4ea64	20817c66-3be1-4450-8be9-a922838cec1f	g.chr15:90167027A>C	ENST00000268138.7	+	20	3591	c.3486A>C	c.(3484-3486)tcA>tcC	p.S1162S	KIF7_ENST00000558928.1_Intron|TICRR_ENST00000560985.1_Silent_p.S1161S					TOPBP1-interacting checkpoint and replication regulator									p.S1162S(1)									ACTCCTCCTCACCCGGCCATG	0.473000													9	109					0	0	0.069234	0	0
CCDC125	202243	broad.mit.edu	37	5	68616341	68616341	+	Missense_Mutation	SNP	A	A	C			TCGA-75-6212-01A-11D-1753-08	TCGA-75-6212-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0f2af4c9-05a8-4c97-ac2d-af9241b4ea64	20817c66-3be1-4450-8be9-a922838cec1f	g.chr5:68616341A>C	ENST00000396496.2	-	2	134	c.27T>G	c.(25-27)agT>agG	p.S9R	CCDC125_ENST00000460090.1_5'UTR|CCDC125_ENST00000396499.1_Missense_Mutation_p.S9R|CCDC125_ENST00000383374.2_Missense_Mutation_p.S9R|CCDC125_ENST00000511257.1_5'UTR			Q86Z20	CC125_HUMAN	coiled-coil domain containing 125	9						cytoplasm		p.S9R(1)		breast(2)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(7)|urinary_tract(1)	19		Lung NSC(167;7.26e-05)|Prostate(74;0.0143)|Ovarian(174;0.0448)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;2.2e-56)|Epithelial(20;2.31e-52)|all cancers(19;5.85e-48)|Lung(70;0.0183)		CGTCTGACTCACTTGATGATC	0.428000													14	55					0	0	0.033300	0	0
GPHB5	122876	broad.mit.edu	37	14	63784452	63784452	+	RNA	SNP	C	C	T			TCGA-75-6212-01A-11D-1753-08	TCGA-75-6212-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0f2af4c9-05a8-4c97-ac2d-af9241b4ea64	20817c66-3be1-4450-8be9-a922838cec1f	g.chr14:63784452C>T	ENST00000539258.1	-	0	168							Q86YW7	GPHB5_HUMAN	glycoprotein hormone beta 5							extracellular region	hormone activity	p.V38M(2)		breast(1)|endometrium(1)|lung(4)|urinary_tract(1)	7				OV - Ovarian serous cystadenocarcinoma(108;0.00372)|all cancers(60;0.0226)|BRCA - Breast invasive adenocarcinoma(234;0.0978)		AACTCCCTCACGGCACAGCCC	0.622000													5	47					0	0	0.014758	0	0
TMPRSS13	84000	broad.mit.edu	37	11	117784512	117784512	+	Silent	SNP	G	G	A			TCGA-75-6212-01A-11D-1753-08	TCGA-75-6212-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0f2af4c9-05a8-4c97-ac2d-af9241b4ea64	20817c66-3be1-4450-8be9-a922838cec1f	g.chr11:117784512G>A	ENST00000528626.1	-	4	757	c.684C>T	c.(682-684)tgC>tgT	p.C228C	TMPRSS13_ENST00000524993.1_Silent_p.C263C|TMPRSS13_ENST00000526090.1_Silent_p.C263C|TMPRSS13_ENST00000445164.2_Silent_p.C263C|TMPRSS13_ENST00000430170.2_Silent_p.C263C	NM_001206789.1	NP_001193718.1	Q9BYE2	TMPSD_HUMAN	transmembrane protease, serine 13	258	SRCR.				proteolysis	integral to membrane	scavenger receptor activity|serine-type endopeptidase activity	p.C263C(1)		endometrium(1)|kidney(3)|large_intestine(6)|lung(7)|pancreas(1)|prostate(1)|urinary_tract(1)	20	all_hematologic(175;0.0487)	Medulloblastoma(222;0.0425)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;1.78e-05)|Epithelial(105;0.00106)		CCAGCTGCTGGCAGGTCTTCT	0.537000													13	55					0	0	0.020292	0	0
POTEC	388468	broad.mit.edu	37	18	14513675	14513675	+	Missense_Mutation	SNP	T	T	C			TCGA-75-6212-01A-11D-1753-08	TCGA-75-6212-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0f2af4c9-05a8-4c97-ac2d-af9241b4ea64	20817c66-3be1-4450-8be9-a922838cec1f	g.chr18:14513675T>C	ENST00000358970.5	-	10	1518	c.1519A>G	c.(1519-1521)Aaa>Gaa	p.K507E		NM_001137671.1	NP_001131143.1	B2RU33	POTEC_HUMAN	POTE ankyrin domain family, member C	507								p.K507E(2)		NS(2)|breast(1)|endometrium(9)|kidney(13)|lung(14)|prostate(3)|skin(6)|soft_tissue(1)|urinary_tract(3)	52						GAATTCATTTTCTTTTCAGCC	0.284000													3	62					0	0	0.004672	0	0
KIF9	64147	broad.mit.edu	37	3	47288871	47288871	+	Missense_Mutation	SNP	C	C	T			TCGA-75-6212-01A-11D-1753-08	TCGA-75-6212-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0f2af4c9-05a8-4c97-ac2d-af9241b4ea64	20817c66-3be1-4450-8be9-a922838cec1f	g.chr3:47288871C>T	ENST00000335044.2	-	12	1582	c.1225G>A	c.(1225-1227)Gag>Aag	p.E409K	KIF9_ENST00000452770.2_Missense_Mutation_p.E409K|KIF9_ENST00000487440.1_5'UTR|KIF9_ENST00000444589.2_Missense_Mutation_p.E409K|KIF9_ENST00000265529.3_Missense_Mutation_p.E409K|KIF9_ENST00000352910.4_Missense_Mutation_p.E316K	NM_001134878.1|NM_182902.3	NP_001128350.1|NP_878905.2	Q9HAQ2	KIF9_HUMAN	kinesin family member 9	409					blood coagulation|microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity	p.E409K(1)		central_nervous_system(1)|endometrium(2)|large_intestine(8)|lung(15)|skin(4)|stomach(2)|upper_aerodigestive_tract(2)	34		Acute lymphoblastic leukemia(5;0.164)		BRCA - Breast invasive adenocarcinoma(193;0.000284)|KIRC - Kidney renal clear cell carcinoma(197;0.00609)|Kidney(197;0.007)		ACGTCGATCTCGTCCAGTGTC	0.592000													10	59					0	0	0.093190	0	0
NHS	4810	broad.mit.edu	37	X	17394368	17394368	+	Missense_Mutation	SNP	G	G	A			TCGA-75-6212-01A-11D-1753-08	TCGA-75-6212-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0f2af4c9-05a8-4c97-ac2d-af9241b4ea64	20817c66-3be1-4450-8be9-a922838cec1f	g.chrX:17394368G>A	ENST00000380060.3	+	1	826	c.488G>A	c.(487-489)cGc>cAc	p.R163H		NM_198270.2	NP_938011.1	Q6T4R5	NHS_HUMAN	Nance-Horan syndrome (congenital cataracts and dental anomalies)	163						nucleus		p.R163H(1)		breast(5)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|liver(1)|lung(26)|ovary(2)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	71	Hepatocellular(33;0.183)					ACCCACCGCCGCGTCTGGGCG	0.716000													3	2					0	0	0.004672	0	0
GOLGA8DP	100132979	broad.mit.edu	37	15	22709637	22709637	+	RNA	SNP	T	T	G	rs140467724	by1000genomes	TCGA-75-6212-01A-11D-1753-08	TCGA-75-6212-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0f2af4c9-05a8-4c97-ac2d-af9241b4ea64	20817c66-3be1-4450-8be9-a922838cec1f	g.chr15:22709637T>G	ENST00000314246.8	-	0	1147																											CCCATCTGGTTTTTGAGTTTG	0.547000													4	180					0	0	0.014758	0	0
ZNF420	147923	broad.mit.edu	37	19	37619247	37619247	+	Missense_Mutation	SNP	T	T	C			TCGA-75-6212-01A-11D-1753-08	TCGA-75-6212-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0f2af4c9-05a8-4c97-ac2d-af9241b4ea64	20817c66-3be1-4450-8be9-a922838cec1f	g.chr19:37619247T>C	ENST00000337995.3	+	5	1569	c.1354T>C	c.(1354-1356)Tgt>Cgt	p.C452R	ZNF420_ENST00000304239.7_Missense_Mutation_p.C452R|ZNF585A_ENST00000588723.1_Intron	NM_144689.3	NP_653290.2	Q8TAQ5	ZN420_HUMAN	zinc finger protein 420	452					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.C452R(1)		breast(2)|endometrium(2)|large_intestine(9)|lung(10)|prostate(1)|skin(3)	27			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			ATGTAAAGAATGTGGAAAAAC	0.403000													8	42					0	0	0.047766	0	0
CHM	1121	broad.mit.edu	37	X	85219008	85219008	+	Missense_Mutation	SNP	G	G	A			TCGA-75-6212-01A-11D-1753-08	TCGA-75-6212-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0f2af4c9-05a8-4c97-ac2d-af9241b4ea64	20817c66-3be1-4450-8be9-a922838cec1f	g.chrX:85219008G>A	ENST00000357749.2	-	5	393	c.364C>T	c.(364-366)Cat>Tat	p.H122Y	CHM_ENST00000537751.1_5'UTR|CHM_ENST00000467744.1_Intron	NM_000390.2	NP_000381.1	P24386	RAE1_HUMAN	choroideremia (Rab escort protein 1)	122					intracellular protein transport|protein geranylgeranylation|response to stimulus|visual perception	Rab-protein geranylgeranyltransferase complex	GTPase activator activity|Rab geranylgeranyltransferase activity	p.H122Y(1)		breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|liver(1)|lung(12)|ovary(1)|prostate(1)	20		all_lung(315;5.41e-06)				ACAAGAGCATGATTTTTCTGC	0.403000													12	60					0	0	0.093190	0	0
SPTA1	6708	broad.mit.edu	37	1	158592861	158592861	+	Missense_Mutation	SNP	G	G	A			TCGA-75-6212-01A-11D-1753-08	TCGA-75-6212-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0f2af4c9-05a8-4c97-ac2d-af9241b4ea64	20817c66-3be1-4450-8be9-a922838cec1f	g.chr1:158592861G>A	ENST00000368148.3	-	43	6212	c.6032C>T	c.(6031-6033)gCc>gTc	p.A2011V	SPTA1_ENST00000461624.1_5'UTR|SPTA1_ENST00000368147.3_Missense_Mutation_p.A2008V	NM_003126.2	NP_003117.2	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1 (elliptocytosis 2)	2011					actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton	p.A2011V(6)		NS(3)|breast(7)|cervix(1)|endometrium(22)|kidney(9)|large_intestine(29)|liver(2)|lung(183)|ovary(5)|prostate(18)|skin(11)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(6)	307	all_hematologic(112;0.0378)					CAGCAGAGCGGCATAACGCTC	0.483000													6	381					0	0	0.029380	0	0
EMR1	2015	broad.mit.edu	37	19	6919679	6919679	+	Missense_Mutation	SNP	G	G	A			TCGA-75-6212-01A-11D-1753-08	TCGA-75-6212-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0f2af4c9-05a8-4c97-ac2d-af9241b4ea64	20817c66-3be1-4450-8be9-a922838cec1f	g.chr19:6919679G>A	ENST00000312053.4	+	13	1578	c.1541G>A	c.(1540-1542)cGa>cAa	p.R514Q	EMR1_ENST00000381404.4_Missense_Mutation_p.R462Q|EMR1_ENST00000450315.3_Missense_Mutation_p.R337Q|EMR1_ENST00000381407.5_Missense_Mutation_p.R373Q|EMR1_ENST00000250572.8_Missense_Mutation_p.R514Q	NM_001974.4	NP_001965.3	Q14246	EMR1_HUMAN	egf-like module containing, mucin-like, hormone receptor-like 1	514	Ser/Thr-rich.				cell adhesion|neuropeptide signaling pathway	integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity	p.R514Q(1)		NS(2)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(11)|lung(31)|ovary(3)|prostate(1)|skin(8)	62	all_hematologic(4;0.166)					ATGAATTCTCGAGTCGTTGGG	0.473000													18	82					0	0	0.043863	0	0
VPS13B	157680	broad.mit.edu	37	8	100836132	100836132	+	Missense_Mutation	SNP	A	A	G			TCGA-75-6212-01A-11D-1753-08	TCGA-75-6212-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0f2af4c9-05a8-4c97-ac2d-af9241b4ea64	20817c66-3be1-4450-8be9-a922838cec1f	g.chr8:100836132A>G	ENST00000358544.2	+	51	9442	c.9331A>G	c.(9331-9333)Ata>Gta	p.I3111V	VPS13B_ENST00000395996.1_3'UTR|VPS13B_ENST00000357162.2_Missense_Mutation_p.I3086V	NM_017890.4	NP_060360.3	Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13 homolog B (yeast)	3111					protein transport			p.I3111V(1)|p.I3086V(1)		NS(1)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(37)|lung(78)|ovary(8)|pancreas(3)|prostate(5)|skin(9)|upper_aerodigestive_tract(4)|urinary_tract(9)	193	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			CAAGACTACAATAATCAATAA	0.318000													29	113					0	0	0.037714	0	0
AFF1	4299	broad.mit.edu	37	4	87968334	87968334	+	Missense_Mutation	SNP	C	C	T			TCGA-75-6212-01A-11D-1753-08	TCGA-75-6212-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0f2af4c9-05a8-4c97-ac2d-af9241b4ea64	20817c66-3be1-4450-8be9-a922838cec1f	g.chr4:87968334C>T	ENST00000307808.6	+	3	1046	c.626C>T	c.(625-627)cCc>cTc	p.P209L	AFF1_ENST00000544085.1_Intron|AFF1_ENST00000395146.4_Missense_Mutation_p.P216L	NM_005935.2	NP_005926.1	P51825	AFF1_HUMAN	AF4/FMR2 family, member 1	209			P -> A (in dbSNP:rs3733378).			nucleus	sequence-specific DNA binding transcription factor activity	p.P216L(1)		breast(1)|large_intestine(2)	3		Acute lymphoblastic leukemia(40;0.0935)|all_hematologic(202;0.111)|Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000233)		TCCCCAGTTCCCCCTTTGTCA	0.522000													20	103					0	0	0.043863	0	0
NKD1	85407	broad.mit.edu	37	16	50667219	50667219	+	Missense_Mutation	SNP	G	G	A			TCGA-75-6212-01A-11D-1753-08	TCGA-75-6212-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0f2af4c9-05a8-4c97-ac2d-af9241b4ea64	20817c66-3be1-4450-8be9-a922838cec1f	g.chr16:50667219G>A	ENST00000268459.3	+	10	1164	c.940G>A	c.(940-942)Gac>Aac	p.D314N		NM_033119.4	NP_149110.1	Q969G9	NKD1_HUMAN	naked cuticle homolog 1 (Drosophila)	314					Wnt receptor signaling pathway	cytoplasm|plasma membrane	calcium ion binding|protein binding	p.D314N(1)		NS(1)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(5)|lung(9)|prostate(1)|urinary_tract(2)	23		all_cancers(37;0.229)		GBM - Glioblastoma multiforme(240;0.243)		CCAAGGCGTGGACCCGGCCTC	0.632000													16	92					0	0	0.038395	0	0
FOSL1	8061	broad.mit.edu	37	11	65660407	65660407	+	Nonsense_Mutation	SNP	C	C	A			TCGA-75-6212-01A-11D-1753-08	TCGA-75-6212-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0f2af4c9-05a8-4c97-ac2d-af9241b4ea64	20817c66-3be1-4450-8be9-a922838cec1f	g.chr11:65660407C>A	ENST00000312562.2	-	4	952	c.766G>T	c.(766-768)Gga>Tga	p.G256*	FOSL1_ENST00000448083.2_Nonsense_Mutation_p.G154*|FOSL1_ENST00000532401.1_3'UTR|FOSL1_ENST00000531493.1_Nonsense_Mutation_p.G220*	NM_005438.3	NP_005429.1	P15407	FOSL1_HUMAN	FOS-like antigen 1	256					cellular defense response|chemotaxis|positive regulation of cell proliferation|response to virus|transcription from RNA polymerase II promoter	nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	p.G256*(1)		breast(1)|endometrium(2)|lung(5)|ovary(1)|upper_aerodigestive_tract(1)	10				READ - Rectum adenocarcinoma(159;0.168)		GATGGGTCTCCGCTGCTGCTG	0.612000													3	42					0.00909568	0.00952881	0.009096	1	0
C2orf57	165100	broad.mit.edu	37	2	232458074	232458074	+	Missense_Mutation	SNP	G	G	A			TCGA-75-6212-01A-11D-1753-08	TCGA-75-6212-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0f2af4c9-05a8-4c97-ac2d-af9241b4ea64	20817c66-3be1-4450-8be9-a922838cec1f	g.chr2:232458074G>A	ENST00000313965.2	+	1	500	c.412G>A	c.(412-414)Gcg>Acg	p.A138T		NM_152614.2	NP_689827.2	Q53QW1	CB057_HUMAN	chromosome 2 open reading frame 57	138								p.A138T(1)		endometrium(1)|kidney(2)|large_intestine(1)|lung(7)|ovary(1)|pancreas(1)|prostate(4)|skin(2)	19		Renal(207;0.025)|all_hematologic(139;0.0735)|Acute lymphoblastic leukemia(138;0.164)		Epithelial(121;1.33e-11)|LUSC - Lung squamous cell carcinoma(224;0.0115)|Lung(119;0.014)		GTCACAAATGGCGAGTGTTCC	0.572000													5	78					0	0	0.021553	0	0
MED23	9439	broad.mit.edu	37	6	131944569	131944569	+	Silent	SNP	A	A	G			TCGA-75-6212-01A-11D-1753-08	TCGA-75-6212-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0f2af4c9-05a8-4c97-ac2d-af9241b4ea64	20817c66-3be1-4450-8be9-a922838cec1f	g.chr6:131944569A>G	ENST00000403834.3	-	5	491	c.318T>C	c.(316-318)acT>acC	p.T106T	MED23_ENST00000540546.1_Silent_p.T106T|MED23_ENST00000354577.4_Silent_p.T106T|MED23_ENST00000368053.4_Silent_p.T106T|MED23_ENST00000368068.3_Silent_p.T106T|MED23_ENST00000368060.3_Silent_p.T106T|MED23_ENST00000539158.1_Silent_p.T106T|MED23_ENST00000368058.1_Silent_p.T106T			Q9ULK4	MED23_HUMAN	mediator complex subunit 23	106					regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	transcription factor complex	protein binding|transcription coactivator activity	p.T106T(2)		NS(1)|breast(3)|central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(12)|lung(15)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	44	Breast(56;0.0753)			GBM - Glioblastoma multiforme(226;0.0115)|OV - Ovarian serous cystadenocarcinoma(155;0.0608)		CCCACTCAAGAGTGTCAGAGT	0.363000													3	108					0	0	0.009096	0	0
SRGAP2-AS1	100873165	broad.mit.edu	37	1	121137803	121137805	+	RNA	DEL	CCA	CCA	-	rs60375635	by1000genomes	TCGA-75-6212-01A-11D-1753-08	TCGA-75-6212-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0f2af4c9-05a8-4c97-ac2d-af9241b4ea64	20817c66-3be1-4450-8be9-a922838cec1f	g.chr1:121137803_121137805delCCA	ENST00000437515.1	-	0	329																											ACCGCCGCCGCCACGGCTTTTTG	0.645													5	6	---	---	---	---					
RP11-608O21.1	0	broad.mit.edu	37	4	19815895	19815895	+	RNA	DEL	A	A	-	rs145239076		TCGA-75-6212-01A-11D-1753-08	TCGA-75-6212-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0f2af4c9-05a8-4c97-ac2d-af9241b4ea64	20817c66-3be1-4450-8be9-a922838cec1f	g.chr4:19815895delA	ENST00000511431.1	+	0	288																											TCTGGGCTGTaaaaaaaaaaa	0.413													3	4	---	---	---	---					
EGFR	1956	broad.mit.edu	37	7	55242466	55242474	+	In_Frame_Del	DEL	GAATTAAGA	GAATTAAGA	-	rs121913438		TCGA-75-6212-01A-11D-1753-08	TCGA-75-6212-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0f2af4c9-05a8-4c97-ac2d-af9241b4ea64	20817c66-3be1-4450-8be9-a922838cec1f	g.chr7:55242466_55242474delGAATTAAGA	ENST00000275493.2	+	19	2413_2421	c.2236_2244delGAATTAAGA	c.(2236-2244)del	p.ELR746del	EGFR_ENST00000442591.1_Intron|EGFR_ENST00000455089.1_In_Frame_Del_p.ELR701del|EGFR_ENST00000454757.2_In_Frame_Del_p.ELR693del	NM_005228.3	NP_005219.2	P00533	EGFR_HUMAN	epidermal growth factor receptor	746	Protein kinase.		Missing (found in a lung cancer sample).		activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.E746_A750del(1007)|p.L747_P753>S(123)|p.L747_A750>P(82)|p.L747_T751del(76)|p.E746_S752>V(57)|p.L747_S752del(34)|p.L747_T751>P(21)|p.E746_T751>A(21)|p.L747_E749del(16)|p.E746_E749del(9)|p.L747_T751>S(7)|p.L747_P753>Q(7)|p.K745_E749del(6)|p.E746_T751>V(6)|p.L747S(6)|p.E746_S752>A(6)|p.E746_T751>VA(6)|p.L747_T751>Q(5)|p.E746_T751del(4)|p.E746_T751>I(4)|p.E746_S752>D(4)|p.E746_S752>I(4)|p.K745_E746insVPVAIK(4)|p.E746_A750>IP(3)|p.L747P(3)|p.L747_S752>Q(3)|p.E746K(3)|p.E746_T751>IP(3)|p.E746_T751>VP(3)|p.E746_A750>RP(2)|p.L747_S752>QH(2)|p.E746_S752del(2)|p.E746_P753>VS(2)|p.E746_A750>QP(2)|p.L747_K754del(2)|p.L747_K754>ST(1)|p.E746_A750>VP(1)|p.L747_P753del(1)|p.E746del(1)|p.L747_K754>N(1)|p.E746_P753>IS(1)|p.E746_T751>L(1)|p.L747_R748>FP(1)|p.L747_T751>A(1)|p.I744_E749>LKR(1)|p.E746_P753>LS(1)|p.E746_T751>Q(1)|p.E746_T751>S(1)|p.E746_P753>VQ(1)|p.E746_A750>DP(1)|p.E746V(1)|p.I744_A750>VK(1)|p.R748I(1)|p.K745_A750del(1)|p.R748K(1)		NS(2)|adrenal_gland(5)|biliary_tract(8)|bone(3)|breast(18)|central_nervous_system(106)|endometrium(26)|eye(3)|haematopoietic_and_lymphoid_tissue(9)|kidney(11)|large_intestine(85)|liver(2)|lung(13575)|oesophagus(21)|ovary(38)|pancreas(3)|peritoneum(11)|pleura(2)|prostate(35)|salivary_gland(11)|skin(9)|small_intestine(1)|soft_tissue(4)|stomach(41)|thymus(2)|thyroid(14)|upper_aerodigestive_tract(59)|urinary_tract(6)	14110	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	CGCTATCAAGGAATTAAGAGAAGCAACAT	0.478	E746K(HCC827_LUNG)|E746_A750del(NCIH1650_LUNG)|E746_A750del(PC14_LUNG)|L747_P753>Q(HCC4006_LUNG)	8	"""A, O, Mis"""		"""glioma, NSCLC"""	NSCLC			Lung Cancer, Familial Clustering of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			26	69	---	---	---	---					
GTF2I	2969	broad.mit.edu	37	7	74114596	74114608	+	Frame_Shift_Del	DEL	CACAGTGGTACCT	CACAGTGGTACCT	-			TCGA-75-6212-01A-11D-1753-08	TCGA-75-6212-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0f2af4c9-05a8-4c97-ac2d-af9241b4ea64	20817c66-3be1-4450-8be9-a922838cec1f	g.chr7:74114596_74114608delCACAGTGGTACCT	ENST00000324896.4	+	5	782_794	c.393_405delCACAGTGGTACCT	c.(391-405)tcfs	p.STVVP131fs	AC083884.8_ENST00000434256.1_RNA|GTF2I_ENST00000416070.1_Frame_Shift_Del_p.STVVP131fs|AC083884.8_ENST00000450426.2_RNA|AC083884.8_ENST00000594967.1_RNA|GTF2I_ENST00000346152.4_Frame_Shift_Del_p.STVVP131fs|GTF2I_ENST00000443166.1_Frame_Shift_Del_p.STVVP131fs|GTF2I_ENST00000353920.4_Frame_Shift_Del_p.STVVP131fs	NM_032999.2	NP_127492.1	P78347	GTF2I_HUMAN	general transcription factor IIi	131					negative regulation of angiogenesis|signal transduction|transcription initiation from RNA polymerase II promoter	cytoplasm|nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			NS(1)|endometrium(7)|kidney(1)|large_intestine(1)|lung(5)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	19						TAGGCAAATCCACAGTGGTACCTGTACCATATG	0.460													11	96	---	---	---	---					
TPTE2P1	646405	broad.mit.edu	37	13	25527490	25527491	+	RNA	INS	-	-	AAAAAG			TCGA-75-6212-01A-11D-1753-08	TCGA-75-6212-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0f2af4c9-05a8-4c97-ac2d-af9241b4ea64	20817c66-3be1-4450-8be9-a922838cec1f	g.chr13:25527490_25527491insAAAAAG	ENST00000429698.1	-	0	282																											AGGAAGGTTCTAAAAAAAATTT	0.252													4	6	---	---	---	---					
MAX	4149	broad.mit.edu	37	14	65544746	65544748	+	In_Frame_Del	DEL	CCG	CCG	-			TCGA-75-6212-01A-11D-1753-08	TCGA-75-6212-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0f2af4c9-05a8-4c97-ac2d-af9241b4ea64	20817c66-3be1-4450-8be9-a922838cec1f	g.chr14:65544746_65544748delCCG	ENST00000284165.6	-	4	326_328	c.178_180delCGG	c.(178-180)del	p.R60del	MAX_ENST00000555932.1_Intron|MAX_ENST00000556979.1_In_Frame_Del_p.R60del|MAX_ENST00000358402.4_In_Frame_Del_p.R51del|MAX_ENST00000341653.2_Intron|MAX_ENST00000557746.1_In_Frame_Del_p.R51del|MAX_ENST00000557277.1_De_novo_Start_InFrame|MAX_ENST00000358664.4_In_Frame_Del_p.R60del|MAX_ENST00000556443.1_In_Frame_Del_p.R51del|MAX_ENST00000555667.1_In_Frame_Del_p.R51del|MAX_ENST00000555419.1_In_Frame_Del_p.R24del	NM_145113.1	NP_660088.1	P61244	MAX_HUMAN	MYC associated factor X	60	Helix-loop-helix motif.				transcription from RNA polymerase II promoter	cytoplasm|MLL1 complex	sequence-specific DNA binding transcription factor activity|transcription coactivator activity	p.R60Q(5)		breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(1)|lung(3)|prostate(1)|skin(1)	17				all cancers(60;0.000776)|OV - Ovarian serous cystadenocarcinoma(108;0.00359)|BRCA - Breast invasive adenocarcinoma(234;0.00999)		GGATTTGGGCCCGGGATGCCTGT	0.502													33	28	---	---	---	---					
SNHG23	100507242	broad.mit.edu	37	14	101421884	101421888	+	RNA	DEL	ATATT	ATATT	-			TCGA-75-6212-01A-11D-1753-08	TCGA-75-6212-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0f2af4c9-05a8-4c97-ac2d-af9241b4ea64	20817c66-3be1-4450-8be9-a922838cec1f	g.chr14:101421884_101421888delATATT	ENST00000556637.1	+	0	399																											aattttaaaaatattatattattaa	0.283													5	4	---	---	---	---					
CDC27	996	broad.mit.edu	37	17	45219612	45219612	+	Frame_Shift_Del	DEL	A	A	-			TCGA-75-6212-01A-11D-1753-08	TCGA-75-6212-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0f2af4c9-05a8-4c97-ac2d-af9241b4ea64	20817c66-3be1-4450-8be9-a922838cec1f	g.chr17:45219612delA	ENST00000066544.3	-	11	1454	c.1361delT	c.(1360-1362)cafs	p.L454fs	CDC27_ENST00000527547.1_Frame_Shift_Del_p.L454fs|CDC27_ENST00000446365.2_Frame_Shift_Del_p.L393fs|CDC27_ENST00000531206.1_Frame_Shift_Del_p.L460fs	NM_001114091.1|NM_001256.3	NP_001107563.1|NP_001247.3	P30260	CDC27_HUMAN	cell division cycle 27	454					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell proliferation|mitotic cell cycle spindle assembly checkpoint|mitotic metaphase/anaphase transition|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination	anaphase-promoting complex|centrosome|cytosol|nucleoplasm|spindle microtubule	protein phosphatase binding			NS(1)|breast(5)|central_nervous_system(3)|cervix(1)|endometrium(2)|kidney(17)|large_intestine(18)|lung(11)|ovary(5)|pancreas(1)|prostate(19)|skin(5)|upper_aerodigestive_tract(2)	90						TGCTTTTTGTAGATTAAAGGC	0.308													10	47	---	---	---	---