Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
USP9X	8239	broad.mit.edu	37	X	41077680	41077680	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chrX:41077680G>T	ENST00000324545.7	+	37	6898	c.6265G>T	c.(6265-6267)Gct>Tct	p.A2089S	USP9X_ENST00000378308.2_Missense_Mutation_p.A2089S	NM_001039590.2|NM_001039591.2	NP_001034679.2|NP_001034680.2	Q93008	USP9X_HUMAN	ubiquitin specific peptidase 9, X-linked	2089					BMP signaling pathway|cell division|chromosome segregation|female gamete generation|mitosis|protein deubiquitination|transforming growth factor beta receptor signaling pathway|ubiquitin-dependent protein catabolic process	cytoplasm	co-SMAD binding|cysteine-type endopeptidase activity|ubiquitin thiolesterase activity			NS(3)|breast(6)|central_nervous_system(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(16)|lung(29)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	87						TTTTTGGTTTGCTCATAACGT	0.373000													11	32					6.42651e-13	8.03314e-13	1	1	0
CENPJ	55835	broad.mit.edu	37	13	25487104	25487104	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr13:25487104C>G	ENST00000381884.4	-	2	245	c.60G>C	c.(58-60)tgG>tgC	p.W20C	CENPJ_ENST00000545981.1_Missense_Mutation_p.W20C	NM_018451.4	NP_060921.3	Q9HC77	CENPJ_HUMAN	centromere protein J	20					cell division|centriole replication|G2/M transition of mitotic cell cycle|microtubule nucleation|microtubule polymerization	centriole|cytosol|gamma-tubulin small complex|microtubule	protein domain specific binding|tubulin binding			endometrium(5)|kidney(4)|large_intestine(14)|lung(13)|ovary(5)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	47		Lung SC(185;0.0225)|Breast(139;0.0602)		all cancers(112;0.00793)|Epithelial(112;0.0411)|OV - Ovarian serous cystadenocarcinoma(117;0.139)		GATTGGTCATCCACTGGGTTA	0.438000													6	45					0	0	1	0	0
ATP2B1	490	broad.mit.edu	37	12	89992384	89992384	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr12:89992384G>A	ENST00000359142.3	-	20	3712	c.3488C>T	c.(3487-3489)gCt>gTt	p.A1163V	ATP2B1_ENST00000261173.2_Intron|ATP2B1_ENST00000393164.2_Intron|ATP2B1_ENST00000348959.3_Intron|ATP2B1_ENST00000428670.3_Intron	NM_001001323.1	NP_001001323.1	P20020	AT2B1_HUMAN	ATPase, Ca++ transporting, plasma membrane 1	0					ATP biosynthetic process|platelet activation	integral to plasma membrane	ATP binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding|protein binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(13)|lung(15)|ovary(2)|prostate(2)|skin(3)|urinary_tract(1)	45						AGTAGTAGAAGCAGTAGAAGA	0.433000													19	91					0	0	1	0	0
ECD	11319	broad.mit.edu	37	10	74899220	74899220	+	Missense_Mutation	SNP	A	A	G			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr10:74899220A>G	ENST00000372979.4	-	11	1474	c.1268T>C	c.(1267-1269)cTg>cCg	p.L423P	ECD_ENST00000454759.1_Missense_Mutation_p.L380P|ECD_ENST00000430082.1_Missense_Mutation_p.L456P	NM_007265.2	NP_009196.1	O95905	SGT1_HUMAN	ecdysoneless homolog (Drosophila)	423					regulation of glycolysis|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|nucleus	transcription coactivator activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(5)|pancreas(1)|prostate(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	21	Prostate(51;0.0119)					CAGCTGGTCCAGCTGATCTGG	0.453000													15	56					0	0	1	0	0
ZNF91	7644	broad.mit.edu	37	19	23545333	23545333	+	Nonsense_Mutation	SNP	G	G	A			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr19:23545333G>A	ENST00000300619.7	-	4	653	c.448C>T	c.(448-450)Cag>Tag	p.Q150*	ZNF91_ENST00000397082.2_Nonsense_Mutation_p.Q118*|ZNF91_ENST00000599743.1_Intron	NM_003430.2	NP_003421.2	Q05481	ZNF91_HUMAN	zinc finger protein 91	150						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding						all_lung(12;0.0349)|Lung NSC(12;0.0538)|all_epithelial(12;0.0611)				ACTTTGCTCTGGGCAGTTGTG	0.323000													13	37					0	0	1	0	0
NBEAP1	606	broad.mit.edu	37	15	20876539	20876539	+	RNA	SNP	T	T	A	rs146180697	by1000genomes	TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr15:20876539T>A	ENST00000556948.1	-	0	61																											ACCATCAAGGTATTTTGCAAA	0.348000													4	45					0	0	1	0	0
PBX3	5090	broad.mit.edu	37	9	128724493	128724493	+	Splice_Site	SNP	G	G	A			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr9:128724493G>A	ENST00000373487.4	+	8	1265	c.1185_splice	c.e8+1	p.Q395_splice	PBX3_ENST00000342287.5_Intron|PBX3_ENST00000373489.5_Splice_Site_p.Q374_splice|PBX3_ENST00000538998.1_Intron|PBX3_ENST00000373483.2_Splice_Site_p.Q193_splice|PBX3_ENST00000447726.2_Splice_Site_p.Q299_splice			P40426	PBX3_HUMAN	pre-B-cell leukemia homeobox 3	374					anterior compartment pattern formation|posterior compartment specification		sequence-specific DNA binding transcription factor activity			biliary_tract(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(8)|skin(1)|upper_aerodigestive_tract(2)	24						TGCAATCACAGGTAGGAGAAA	0.507000													4	22					0	0	1	0	0
PPP1R3A	5506	broad.mit.edu	37	7	113558434	113558434	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr7:113558434C>A	ENST00000284601.3	-	1	686	c.618G>T	c.(616-618)gaG>gaT	p.E206D		NM_002711.3	NP_002702.2	Q16821	PPR3A_HUMAN	protein phosphatase 1, regulatory subunit 3A	206	CBM21.				glycogen metabolic process	integral to membrane				NS(2)|breast(8)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(14)|liver(1)|lung(43)|ovary(10)|pancreas(7)|prostate(3)|skin(15)|stomach(1)|upper_aerodigestive_tract(2)	121						GTATACAAAACTCAACTTTAC	0.343000													4	19					0.00024832	0.00027197	1	1	0
STYXL1	51657	broad.mit.edu	37	7	75634594	75634594	+	Silent	SNP	G	G	A			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr7:75634594G>A	ENST00000451157.1	-	6	751	c.582C>T	c.(580-582)tcC>tcT	p.S194S	STYXL1_ENST00000431581.1_Silent_p.S194S|STYXL1_ENST00000248600.1_Silent_p.S194S|STYXL1_ENST00000340062.5_Silent_p.S98S|STYXL1_ENST00000360591.3_3'UTR|STYXL1_ENST00000359697.3_Silent_p.S194S			Q9Y6J8	STYL1_HUMAN	serine/threonine/tyrosine interacting-like 1	194	Tyrosine-protein phosphatase.				intracellular signal transduction|protein dephosphorylation	intracellular	protein binding|protein tyrosine/serine/threonine phosphatase activity			endometrium(1)|large_intestine(2)|lung(4)|ovary(1)|prostate(1)|skin(1)	10						CTGTATCCATGGAGACATTGA	0.318000													6	23					0	0	1	0	0
PRAM1	84106	broad.mit.edu	37	19	8564620	8564620	+	Silent	SNP	G	G	C			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr19:8564620G>C	ENST00000423345.4	-	2	592	c.72C>G	c.(70-72)gcC>gcG	p.A24A	PRAM1_ENST00000255612.3_Silent_p.A24A			Q96QH2	PRAM_HUMAN	PML-RARA regulated adaptor molecule 1	24							lipid binding|protein binding			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(5)|prostate(1)|skin(1)	19						CCGGCTGAGAGGCCTGGAACT	0.562000													5	13					0	0	1	0	0
CLUL1	27098	broad.mit.edu	37	18	641426	641426	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr18:641426G>A	ENST00000581619.1	+	7	2016	c.1169G>A	c.(1168-1170)cGg>cAg	p.R390Q	CLUL1_ENST00000540035.1_Missense_Mutation_p.R417Q|CLUL1_ENST00000579494.1_Missense_Mutation_p.R365Q|CLUL1_ENST00000400606.2_Missense_Mutation_p.R365Q|CLUL1_ENST00000338387.7_Missense_Mutation_p.R365Q|C18orf56_ENST00000585033.1_3'UTR			Q15846	CLUL1_HUMAN	clusterin-like 1 (retinal)	365					cell death	extracellular region				NS(1)|breast(1)|endometrium(5)|large_intestine(5)|liver(2)|lung(7)|ovary(2)|skin(1)	24						CAGATGACCCGGAAGCACTTG	0.522000													15	110					0	0	1	0	0
MYH7	4625	broad.mit.edu	37	14	23902380	23902380	+	Missense_Mutation	SNP	T	T	A			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr14:23902380T>A	ENST00000355349.3	-	4	420	c.258A>T	c.(256-258)aaA>aaT	p.K86N		NM_000257.2	NP_000248.2	P12883	MYH7_HUMAN	myosin, heavy chain 7, cardiac muscle, beta	86	Myosin head-like.				adult heart development|muscle filament sliding|regulation of heart rate|ventricular cardiac muscle tissue morphogenesis	focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(3)|breast(4)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(19)|lung(57)|ovary(5)|prostate(9)|skin(5)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(5)	137	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00725)		TGTCCTCGATTTTGTCGAACT	0.587000													23	99					0	0	1	0	0
FAT4	79633	broad.mit.edu	37	4	126372162	126372162	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr4:126372162G>T	ENST00000394329.3	+	9	10004	c.9991G>T	c.(9991-9993)Ggg>Tgg	p.G3331W	FAT4_ENST00000335110.5_Missense_Mutation_p.G1629W	NM_024582.4	NP_078858.4	Q6V0I7	FAT4_HUMAN	FAT atypical cadherin 4	3331	Cadherin 32.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						GGGCACTGATGGGGAGGTACA	0.383000													8	57					3.09899e-07	3.71233e-07	1	1	0
ZBTB9	221504	broad.mit.edu	37	6	33424182	33424182	+	Silent	SNP	A	A	T			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr6:33424182A>T	ENST00000395064.2	+	2	1573	c.1305A>T	c.(1303-1305)ggA>ggT	p.G435G		NM_152735.3	NP_689948.1	Q96C00	ZBTB9_HUMAN	zinc finger and BTB domain containing 9	435					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|lung(6)|skin(1)|upper_aerodigestive_tract(2)	11						CCCATGCTGGAGCCCTGCATG	0.607000													14	100					0	0	1	0	0
MSL3	10943	broad.mit.edu	37	X	11793130	11793130	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chrX:11793130C>T	ENST00000380693.3	+	12	1637	c.1000C>T	c.(1000-1002)Cca>Tca	p.P334S	MSL3_ENST00000312196.4_Missense_Mutation_p.P500S|MSL3_ENST00000361672.2_Missense_Mutation_p.P351S|MSL3_ENST00000398527.2_Missense_Mutation_p.P488S	NM_006800.3	NP_006791.2	Q8N5Y2	MS3L1_HUMAN	male-specific lethal 3 homolog (Drosophila)	500					histone H4-K16 acetylation|multicellular organismal development|transcription from RNA polymerase II promoter	MSL complex	DNA binding|methylated histone residue binding|sequence-specific DNA binding transcription factor activity			breast(1)|central_nervous_system(3)|cervix(1)|kidney(3)|large_intestine(3)|lung(6)|ovary(1)|urinary_tract(1)	19						TGACTTCTTCCCAGAGTCGGC	0.423000													3	38					0	0	1	0	0
ATXN1	6310	broad.mit.edu	37	6	16328069	16328069	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr6:16328069G>T	ENST00000244769.4	-	8	1409	c.473C>A	c.(472-474)gCa>gAa	p.A158E	ATXN1_ENST00000436367.1_Missense_Mutation_p.A158E	NM_000332.3	NP_000323.2	P54253	ATX1_HUMAN	ataxin 1	158					cell death|negative regulation of transcription, DNA-dependent|nuclear export|RNA processing	cytoplasm|nuclear inclusion body|nuclear matrix|nucleoplasm	identical protein binding|poly(G) RNA binding|poly(U) RNA binding|protein binding|protein C-terminus binding|protein self-association			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(11)|lung(12)|prostate(2)|skin(7)|upper_aerodigestive_tract(2)	44	Breast(50;0.063)|Ovarian(93;0.0733)	all_hematologic(90;0.000682)|Ovarian(999;0.00973)				CGAGGCCACTGCACTGGTGAC	0.627000													34	115					1.90571e-15	2.43507e-15	1	1	0
KCNC1	3746	broad.mit.edu	37	11	17757663	17757663	+	Silent	SNP	G	G	A			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr11:17757663G>A	ENST00000379472.3	+	1	144	c.114G>A	c.(112-114)gcG>gcA	p.A38A	KCNC1_ENST00000265969.6_Silent_p.A38A	NM_004976.4	NP_004967.1	P48547	KCNC1_HUMAN	potassium voltage-gated channel, Shaw-related subfamily, member 1	38						voltage-gated potassium channel complex	voltage-gated potassium channel activity			breast(1)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(9)|lung(7)|pancreas(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	33						CCTGGCTGGCGGAGCCCGACG	0.682000													4	18					0	0	1	0	0
KDR	3791	broad.mit.edu	37	4	55981109	55981109	+	Missense_Mutation	SNP	A	A	T			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr4:55981109A>T	ENST00000263923.4	-	5	885	c.590T>A	c.(589-591)aTg>aAg	p.M197K		NM_002253.2	NP_002244.1	P35968	VGFR2_HUMAN	kinase insert domain receptor (a type III receptor tyrosine kinase)	197	Ig-like C2-type 2.				angiogenesis|cell differentiation|interspecies interaction between organisms|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of focal adhesion assembly|positive regulation of positive chemotaxis|regulation of cell shape	integral to plasma membrane	ATP binding|growth factor binding|Hsp90 protein binding|integrin binding|receptor signaling protein tyrosine kinase activity|vascular endothelial growth factor receptor activity			NS(1)|breast(3)|central_nervous_system(4)|endometrium(2)|haematopoietic_and_lymphoid_tissue(6)|kidney(8)|large_intestine(16)|lung(71)|ovary(2)|prostate(2)|skin(10)|soft_tissue(4)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	135	all_cancers(7;0.0255)|all_lung(4;0.00175)|Lung NSC(11;0.00384)|all_epithelial(27;0.034)|Glioma(25;0.08)|all_neural(26;0.101)		Epithelial(7;0.189)		Sorafenib(DB00398)|Sunitinib(DB01268)	ACAGAAGACCATGCCAGCATA	0.383000			Mis		"""NSCLC, angiosarcoma"""					TSP Lung(20;0.16)			3	24					0	0	1	0	0
EYS	346007	broad.mit.edu	37	6	66205100	66205100	+	Silent	SNP	A	A	T			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr6:66205100A>T	ENST00000503581.1	-	4	741	c.204T>A	c.(202-204)acT>acA	p.T68T	EYS_ENST00000393380.2_Silent_p.T68T|EYS_ENST00000370618.3_Silent_p.T68T|EYS_ENST00000342421.5_Silent_p.T68T|EYS_ENST00000370616.2_Silent_p.T68T|EYS_ENST00000370621.3_Silent_p.T68T	NM_001142800.1	NP_001136272.1	Q5T1H1	EYS_HUMAN	eyes shut homolog (Drosophila)	68					response to stimulus|visual perception	extracellular region	calcium ion binding			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(42)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)	69						GATTGCCTGAAGTATCTATTT	0.368000													8	80					0	0	1	0	0
GNA12	2768	broad.mit.edu	37	7	2834581	2834581	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr7:2834581C>T	ENST00000275364.3	-	2	668	c.506G>A	c.(505-507)cGg>cAg	p.R169Q	GNA12_ENST00000407904.3_Missense_Mutation_p.R110Q|GNA12_ENST00000544127.1_Missense_Mutation_p.R93Q	NM_007353.2	NP_031379.2	Q03113	GNA12_HUMAN	guanine nucleotide binding protein (G protein) alpha 12	169					G-protein signaling, coupled to cAMP nucleotide second messenger|platelet activation|Rho protein signal transduction	brush border membrane|heterotrimeric G-protein complex	D5 dopamine receptor binding|G-protein beta/gamma-subunit complex binding|GTP binding|GTPase activity|signal transducer activity			endometrium(1)|large_intestine(5)|lung(3)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	13		Ovarian(82;0.0112)		OV - Ovarian serous cystadenocarcinoma(56;1.02e-13)		CTCGCTTCTCCGGCTGAAAGC	0.552000													4	99					0	0	1	0	0
VEGFA	7422	broad.mit.edu	37	6	43745332	43745332	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr6:43745332G>T	ENST00000372067.3	+	3	1279	c.785G>T	c.(784-786)cGa>cTa	p.R262L	VEGFA_ENST00000520948.1_Missense_Mutation_p.R82L|VEGFA_ENST00000523125.1_Missense_Mutation_p.R82L|VEGFA_ENST00000324450.6_Missense_Mutation_p.R262L|VEGFA_ENST00000518824.1_Missense_Mutation_p.R82L|VEGFA_ENST00000457104.2_Missense_Mutation_p.R82L|VEGFA_ENST00000230480.6_Missense_Mutation_p.R54L|VEGFA_ENST00000518689.1_Missense_Mutation_p.R82L|VEGFA_ENST00000523873.1_Missense_Mutation_p.R82L|VEGFA_ENST00000413642.3_Missense_Mutation_p.R262L|VEGFA_ENST00000523950.1_Missense_Mutation_p.R82L|VEGFA_ENST00000417285.2_Missense_Mutation_p.R262L|VEGFA_ENST00000482630.2_Missense_Mutation_p.R262L|VEGFA_ENST00000372064.4_Missense_Mutation_p.R262L|VEGFA_ENST00000425836.2_Missense_Mutation_p.R262L|VEGFA_ENST00000372077.4_Missense_Mutation_p.R82L|VEGFA_ENST00000372055.4_Missense_Mutation_p.R262L	NM_001025366.2|NM_001025367.2|NM_001025368.2|NM_001025369.2|NM_001033756.2|NM_001171623.1|NM_001171624.1|NM_001171625.1|NM_001171626.1|NM_001171627.1|NM_001171629.1|NM_003376.5	NP_001020537.2|NP_001020538.2|NP_001020539.2|NP_001020540.2|NP_001028928.1|NP_001165094.1|NP_001165095.1|NP_001165096.1|NP_001165097.1|NP_001165098.1|NP_001165100.1|NP_003367.4	P15692	VEGFA_HUMAN	vascular endothelial growth factor A	82					basophil chemotaxis|cellular response to hypoxia|induction of positive chemotaxis|platelet activation|platelet degranulation|platelet-derived growth factor receptor signaling pathway|positive regulation of angiogenesis|positive regulation of blood vessel endothelial cell migration|positive regulation of cell adhesion|positive regulation of cell division|positive regulation of endothelial cell proliferation|positive regulation of leukocyte migration|positive regulation of mast cell chemotaxis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of vascular endothelial growth factor receptor signaling pathway|positive regulation of vascular permeability|regulation of cell shape|vascular endothelial growth factor receptor signaling pathway|vasculogenesis	cell surface|extracellular space|membrane|platelet alpha granule lumen	cell surface binding|chemoattractant activity|cytokine activity|fibronectin binding|growth factor activity|heparin binding|platelet-derived growth factor receptor binding|protein heterodimerization activity|protein homodimerization activity|vascular endothelial growth factor receptor 1 binding|vascular endothelial growth factor receptor 2 binding|vascular endothelial growth factor receptor binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(1)|ovary(1)|prostate(1)	9	all_cancers(18;5.46e-07)|all_epithelial(2;5.96e-08)|Lung NSC(15;0.000157)|all_lung(25;0.000486)|Hepatocellular(11;0.00309)		all cancers(41;0.000413)|Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|STAD - Stomach adenocarcinoma(11;0.0742)|OV - Ovarian serous cystadenocarcinoma(102;0.196)		Atorvastatin(DB01076)|Bevacizumab(DB00112)|Carvedilol(DB01136)|Ginkgo biloba(DB01381)|Gliclazide(DB01120)|Minocycline(DB01017)|Ranibizumab(DB01270)|Simvastatin(DB00641)	CCCCTGATGCGATGCGGGGGC	0.587000													18	59					1.33834e-09	1.65493e-09	1	1	0
ANKFN1	162282	broad.mit.edu	37	17	54428148	54428148	+	Silent	SNP	G	G	A			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr17:54428148G>A	ENST00000566473.2	+	4	219	c.219G>A	c.(217-219)acG>acA	p.T73T	ANKFN1_ENST00000318698.2_Silent_p.T73T			Q8N957	ANKF1_HUMAN	ankyrin-repeat and fibronectin type III domain containing 1	73								p.T73T(1)		NS(1)|breast(1)|cervix(2)|endometrium(4)|kidney(4)|large_intestine(11)|lung(27)|ovary(1)|prostate(1)|skin(1)	53						TGAAAATGACGCAACAAATGC	0.388000													10	44					0	0	1	0	0
ERCC5	2073	broad.mit.edu	37	13	103528149	103528149	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr13:103528149G>A	ENST00000355739.4	+	15	4880	c.3457G>A	c.(3457-3459)Gac>Aac	p.D1153N	ERCC5_ENST00000472247.1_3'UTR|ERCC5_ENST00000375954.1_Missense_Mutation_p.D386N	NM_000123.3	NP_000114.2			excision repair cross-complementing rodent repair deficiency, complementation group 5											breast(3)|central_nervous_system(1)|cervix(2)|endometrium(2)|kidney(4)|large_intestine(8)|lung(18)|ovary(5)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	51	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.211)					TGATAGTGATGACGATGGAGG	0.493000			"""Mis, N, F"""			"""skin basal cell, skin squamous cell, melanoma"""		Nucleotide excision repair (NER)	Xeroderma Pigmentosum				13	21					0	0	1	0	0
RAB15	376267	broad.mit.edu	37	14	65417809	65417809	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr14:65417809C>A	ENST00000533601.2	-	4	644	c.307G>T	c.(307-309)Gtc>Ttc	p.V103F	RAB15_ENST00000426039.3_Missense_Mutation_p.V57F|RAB15_ENST00000267512.5_Missense_Mutation_p.V103F|CHURC1-FNTB_ENST00000447296.2_Intron|RAB15_ENST00000436278.2_Missense_Mutation_p.V57F|CHURC1-FNTB_ENST00000542227.1_Intron			P59190	RAB15_HUMAN	RAB15, member RAS oncogene family	103					protein transport|small GTPase mediated signal transduction	plasma membrane	GTP binding			endometrium(1)|large_intestine(2)|lung(4)|ovary(1)	8				all cancers(60;0.00136)|OV - Ovarian serous cystadenocarcinoma(108;0.00593)|BRCA - Breast invasive adenocarcinoma(234;0.0102)		ACGTCACTGACCCACTTCATG	0.542000													4	72					0.014758	0.0155704	1	1	0
TMC5	79838	broad.mit.edu	37	16	19485537	19485537	+	Missense_Mutation	SNP	A	A	T			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr16:19485537A>T	ENST00000396229.2	+	12	2778	c.2029A>T	c.(2029-2031)Atg>Ttg	p.M677L	TMC5_ENST00000561503.1_Missense_Mutation_p.M318L|TMC5_ENST00000541464.1_Missense_Mutation_p.M625L|TMC5_ENST00000219821.5_Missense_Mutation_p.M431L|TMC5_ENST00000564959.1_Missense_Mutation_p.M360L|TMC5_ENST00000542583.2_Missense_Mutation_p.M677L|TMC5_ENST00000381414.4_Missense_Mutation_p.M677L	NM_001105248.1	NP_001098718.1	Q6UXY8	TMC5_HUMAN	transmembrane channel-like 5	677						integral to membrane				NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(3)|liver(2)|lung(12)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	31						CATCTACTCCATGTTCAGGCT	0.552000													5	157					0	0	1	0	0
TLR4	7099	broad.mit.edu	37	9	120475991	120475991	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr9:120475991C>A	ENST00000355622.6	+	3	1686	c.1585C>A	c.(1585-1587)Cac>Aac	p.H529N	TLR4_ENST00000394487.4_Missense_Mutation_p.H489N|TLR4_ENST00000472304.1_3'UTR	NM_138554.4|NM_138557.2	NP_612564.1|NP_612567.1	O00206	TLR4_HUMAN	toll-like receptor 4	529					activation of MAPK activity|cellular response to mechanical stimulus|detection of fungus|detection of lipopolysaccharide|I-kappaB phosphorylation|innate immune response|intestinal epithelial structure maintenance|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of ERK1 and ERK2 cascade|negative regulation of interferon-gamma production|negative regulation of interleukin-17 production|negative regulation of interleukin-23 production|negative regulation of interleukin-6 production|negative regulation of osteoclast differentiation|negative regulation of tumor necrosis factor production|positive regulation of chemokine production|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of interferon-gamma production|positive regulation of interleukin-1 production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 biosynthetic process|positive regulation of interleukin-12 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 biosynthetic process|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of platelet activation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor biosynthetic process|positive regulation of tumor necrosis factor production|T-helper 1 type immune response|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	external side of plasma membrane|integral to plasma membrane|lipopolysaccharide receptor complex|perinuclear region of cytoplasm	lipopolysaccharide receptor activity|transmembrane receptor activity			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(12)|lung(66)|ovary(4)|pancreas(1)|skin(6)|upper_aerodigestive_tract(5)|urinary_tract(1)	103						AAATATGAGCCACAACAACTT	0.413000													4	19					0.184627	0.184627	1	1	0
HIST1H2AK	8330	broad.mit.edu	37	6	27806013	27806013	+	Silent	SNP	G	G	A			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr6:27806013G>A	ENST00000330180.2	-	1	104	c.105C>T	c.(103-105)ctC>ctT	p.L35L		NM_003510.2	NP_003501.1	P0C0S8	H2A1_HUMAN	histone cluster 1, H2ak	35					nucleosome assembly	nucleosome|nucleus	DNA binding|enzyme binding			breast(2)|endometrium(2)|kidney(1)|lung(3)|upper_aerodigestive_tract(2)	10						TGCCCTTGCGGAGCAGTCGGT	0.662000													6	60					0	0	1	0	0
C5orf54	63920	broad.mit.edu	37	5	159822295	159822295	+	Missense_Mutation	SNP	T	T	A			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr5:159822295T>A	ENST00000408953.3	-	2	710	c.203A>T	c.(202-204)cAt>cTt	p.H68L	C5orf54_ENST00000523213.1_Missense_Mutation_p.H68L	NM_022090.3	NP_071373.2	Q8IZ13	CE054_HUMAN	chromosome 5 open reading frame 54	68										breast(1)|endometrium(1)|kidney(2)|large_intestine(4)|pancreas(1)|prostate(1)|skin(1)|urinary_tract(1)	12						tgctggcatatgcttcaggct	0.408000													16	99					0	0	1	0	0
ZNF613	79898	broad.mit.edu	37	19	52447726	52447726	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr19:52447726C>A	ENST00000293471.6	+	6	1269	c.590C>A	c.(589-591)aCt>aAt	p.T197N	ZNF613_ENST00000391794.4_Missense_Mutation_p.T161N	NM_001031721.3	NP_001026891.2	Q6PF04	ZN613_HUMAN	zinc finger protein 613	197					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(3)|lung(8)|ovary(1)|skin(1)|urinary_tract(1)	19		all_neural(266;0.117)		GBM - Glioblastoma multiforme(134;0.00148)|OV - Ovarian serous cystadenocarcinoma(262;0.0183)		CATCAGCGAACTCAAAACATA	0.408000													52	193					3.4597e-24	4.57317e-24	1	1	0
PCDHB15	56121	broad.mit.edu	37	5	140627195	140627195	+	Silent	SNP	C	C	T			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr5:140627195C>T	ENST00000231173.3	+	1	2049	c.2049C>T	c.(2047-2049)gcC>gcT	p.A683A		NM_018935.2	NP_061758.1	Q9Y5E8	PCDBF_HUMAN		683					homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding	p.A683A(1)		NS(1)|breast(3)|endometrium(8)|kidney(3)|large_intestine(14)|liver(1)|lung(18)|ovary(3)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)	61			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			AAGCCCAGGCCGACTCGCTTA	0.672000													46	132					0	0	1	0	0
SPCS2	9789	broad.mit.edu	37	11	74676882	74676882	+	Silent	SNP	C	C	T			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr11:74676882C>T	ENST00000263672.6	+	3	312	c.273C>T	c.(271-273)tcC>tcT	p.S91S	SPCS2_ENST00000530257.1_Intron|SPCS2_ENST00000526361.1_Intron|SPCS2_ENST00000528265.1_Intron	NM_014752.2	NP_055567.2	Q15005	SPCS2_HUMAN	signal peptidase complex subunit 2 homolog (S. cerevisiae)	91					energy reserve metabolic process|regulation of insulin secretion|signal peptide processing	integral to membrane|microsome|signal peptidase complex	peptidase activity			breast(1)	1						GTACAATCTCCTGTTTCTTTG	0.393000													9	52					0	0	1	0	0
FAM49B	51571	broad.mit.edu	37	8	130883703	130883703	+	Missense_Mutation	SNP	T	T	C			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr8:130883703T>C	ENST00000519824.2	-	4	386	c.113A>G	c.(112-114)cAg>cGg	p.Q38R	FAM49B_ENST00000522250.1_5'UTR|FAM49B_ENST00000519540.1_Missense_Mutation_p.Q38R|FAM49B_ENST00000518879.1_Intron|FAM49B_ENST00000517654.1_Missense_Mutation_p.Q38R|FAM49B_ENST00000519110.1_Missense_Mutation_p.Q38R|FAM49B_ENST00000522941.1_5'UTR|FAM49B_ENST00000522746.1_Missense_Mutation_p.Q38R|FAM49B_ENST00000401979.2_Missense_Mutation_p.Q38R|FAM49B_ENST00000523509.1_Missense_Mutation_p.Q38R	NM_016623.4	NP_057707.3	Q9NUQ9	FA49B_HUMAN	family with sequence similarity 49, member B	38										kidney(1)|large_intestine(6)|lung(4)|prostate(1)	12	Ovarian(5;0.000567)|Esophageal squamous(12;0.00693)|Acute lymphoblastic leukemia(118;0.155)		LUAD - Lung adenocarcinoma(14;0.0989)			TACATTCACCTGATTATAAAT	0.388000													4	45					0	0	1	0	0
DHX8	1659	broad.mit.edu	37	17	41569551	41569551	+	Splice_Site	SNP	A	A	T			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr17:41569551A>T	ENST00000262415.3	+	5	466	c.393_splice	c.e5-1	p.T132_splice	DHX8_ENST00000540306.1_Splice_Site_p.T132_splice	NM_004941.1	NP_004932.1	Q14562	DHX8_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 8	132						catalytic step 2 spliceosome	ATP binding|ATP-dependent RNA helicase activity|protein binding|RNA binding			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(9)|lung(17)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|urinary_tract(1)	42		Breast(137;0.00908)		BRCA - Breast invasive adenocarcinoma(366;0.08)		ACCTCTGCAGACCATGTTGGA	0.443000													8	26					0	0	1	0	0
RYR1	6261	broad.mit.edu	37	19	38979989	38979989	+	Missense_Mutation	SNP	A	A	G			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr19:38979989A>G	ENST00000355481.4	+	35	5851	c.5720A>G	c.(5719-5721)gAa>gGa	p.E1907G	RYR1_ENST00000359596.3_Missense_Mutation_p.E1907G|RYR1_ENST00000360985.3_Missense_Mutation_p.E1907G	NM_000540.2|NM_001042723.1	NP_000531.2|NP_001036188.1	P21817	RYR1_HUMAN	ryanodine receptor 1 (skeletal)	1907	6 X approximate repeats.|Glu-rich (acidic).				muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(4)|autonomic_ganglia(2)|breast(3)|central_nervous_system(5)|endometrium(26)|haematopoietic_and_lymphoid_tissue(3)|kidney(34)|large_intestine(42)|liver(1)|lung(106)|ovary(11)|pancreas(5)|prostate(9)|skin(12)|stomach(11)|upper_aerodigestive_tract(4)|urinary_tract(7)	285	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	gaagatgaggaaaaagaggaa	0.527000													13	33					0	0	1	0	0
CAMK2B	816	broad.mit.edu	37	7	44268445	44268445	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr7:44268445C>G	ENST00000395749.2	-	19	1494	c.1418G>C	c.(1417-1419)gGg>gCg	p.G473A	CAMK2B_ENST00000440254.2_Intron|CAMK2B_ENST00000353625.4_Intron|CAMK2B_ENST00000502837.2_Intron|CAMK2B_ENST00000457475.1_Intron|CAMK2B_ENST00000489429.1_5'UTR|CAMK2B_ENST00000395747.2_Intron|CAMK2B_ENST00000358707.3_Intron|CAMK2B_ENST00000350811.3_Intron|CAMK2B_ENST00000347193.4_Intron|CAMK2B_ENST00000346990.4_Intron|CAMK2B_ENST00000258682.6_Intron	NM_001220.4	NP_001211.3	Q13554	KCC2B_HUMAN	calcium/calmodulin-dependent protein kinase II beta	473					interferon-gamma-mediated signaling pathway|synaptic transmission	cytosol|endocytic vesicle membrane|nucleoplasm|plasma membrane	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(6)|ovary(2)|skin(1)	18						GGGCGGGGGCCCCGCTGAGAG	0.677000													5	0					0	0	1	0	0
ATP7B	540	broad.mit.edu	37	13	52509127	52509127	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr13:52509127G>A	ENST00000242839.4	-	21	4319	c.4163C>T	c.(4162-4164)gCg>gTg	p.A1388V	ATP7B_ENST00000417240.2_Missense_Mutation_p.A599V|ATP7B_ENST00000448424.2_Missense_Mutation_p.A1310V|ATP7B_ENST00000400366.3_Missense_Mutation_p.A1277V|ATP7B_ENST00000400370.3_Missense_Mutation_p.A958V|ATP7B_ENST00000344297.5_Missense_Mutation_p.A1181V|ATP7B_ENST00000418097.2_Missense_Mutation_p.A1323V	NM_000053.3	NP_000044.2	P35670	ATP7B_HUMAN	ATPase, Cu++ transporting, beta polypeptide	1388					ATP biosynthetic process|cellular copper ion homeostasis|copper ion import|response to copper ion|sequestering of calcium ion	Golgi membrane|integral to plasma membrane|late endosome|mitochondrion	ATP binding|copper ion binding|copper-exporting ATPase activity|protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(5)|kidney(4)|large_intestine(7)|lung(23)|ovary(1)|prostate(3)|skin(4)|stomach(2)	55		Breast(56;0.000207)|Lung NSC(96;0.000845)|Prostate(109;0.0235)|Hepatocellular(98;0.065)|all_neural(104;0.19)		GBM - Glioblastoma multiforme(99;5.25e-08)		GTGGCCATGCGCCTGTGCCTC	0.547000									Wilson disease				11	45					0	0	1	0	0
TLE4	7091	broad.mit.edu	37	9	82323092	82323092	+	Silent	SNP	G	G	T			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr9:82323092G>T	ENST00000376520.4	+	13	1920	c.1092G>T	c.(1090-1092)gcG>gcT	p.A364A	TLE4_ENST00000376537.4_Silent_p.A364A|TLE4_ENST00000376534.4_5'UTR|TLE4_ENST00000376552.2_Silent_p.A332A|TLE4_ENST00000265284.6_Silent_p.A307A|TLE4_ENST00000376544.3_Silent_p.A263A			O60756	BCE1_HUMAN	transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)	0										breast(2)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(10)|lung(12)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	39						GAACTGATGCGCCCACCCCAG	0.438000													12	75					5.50884e-06	6.46445e-06	1	1	0
CCDC90B	60492	broad.mit.edu	37	11	82972966	82972966	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr11:82972966C>G	ENST00000529689.1	-	9	1186	c.752G>C	c.(751-753)aGa>aCa	p.R251T	CCDC90B_ENST00000525504.1_5'UTR|CCDC90B_ENST00000529611.1_Missense_Mutation_p.R150T|CCDC90B_ENST00000525503.1_Missense_Mutation_p.R150T|CCDC90B_ENST00000455220.2_Missense_Mutation_p.R242T			Q9GZT6	CC90B_HUMAN	coiled-coil domain containing 90B	251						integral to membrane|mitochondrion				kidney(2)|large_intestine(2)|lung(4)|ovary(1)|skin(1)	10		Acute lymphoblastic leukemia(157;0.103)				CTTCCAGAATCTATAAAATCC	0.388000													5	99					0	0	1	0	0
SRD5A2	6716	broad.mit.edu	37	2	31805965	31805965	+	RNA	SNP	T	T	A			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr2:31805965T>A	ENST00000405650.1	-	0	171							P31213	S5A2_HUMAN	steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2)						androgen biosynthetic process|cell differentiation|cell-cell signaling|male gonad development	endoplasmic reticulum membrane|integral to membrane|microsome	3-oxo-5-alpha-steroid 4-dehydrogenase activity|sterol 5-alpha reductase activity					Acute lymphoblastic leukemia(172;0.155)				Azelaic Acid(DB00548)|Dutasteride(DB01126)	GCACTGAACCTGCATCGCGCC	0.697000													6	35					0	0	1	0	0
SCN5A	6331	broad.mit.edu	37	3	38591931	38591931	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr3:38591931C>G	ENST00000413689.1	-	28	6125	c.5932G>C	c.(5932-5934)Gac>Cac	p.D1978H	SCN5A_ENST00000423572.2_Missense_Mutation_p.D1977H|SCN5A_ENST00000450102.2_Missense_Mutation_p.D1924H|SCN5A_ENST00000443581.1_Missense_Mutation_p.D1977H|SCN5A_ENST00000451551.2_Missense_Mutation_p.D1924H|SCN5A_ENST00000414099.2_Missense_Mutation_p.D1960H|SCN5A_ENST00000449557.2_Missense_Mutation_p.D1924H|SCN5A_ENST00000455624.2_Missense_Mutation_p.D1945H|SCN5A_ENST00000333535.4_Missense_Mutation_p.D1978H|SCN5A_ENST00000425664.1_Missense_Mutation_p.D1960H	NM_001099404.1|NM_001160160.1	NP_001092874.1|NP_001153632.1	Q14524	SCN5A_HUMAN	sodium channel, voltage-gated, type V, alpha subunit	1978					blood circulation|cellular response to calcium ion|muscle contraction|regulation of heart contraction	sarcolemma|voltage-gated sodium channel complex	protein binding|voltage-gated sodium channel activity			NS(3)|breast(2)|central_nervous_system(3)|cervix(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(25)|lung(27)|ovary(6)|pancreas(3)|prostate(10)|skin(9)|upper_aerodigestive_tract(4)	107	Medulloblastoma(35;0.163)			KIRC - Kidney renal clear cell carcinoma(284;0.0822)|Kidney(284;0.1)	Benzonatate(DB00868)|Bepridil(DB01244)|Carbamazepine(DB00564)|Cocaine(DB00907)|Dibucaine(DB00527)|Disopyramide(DB00280)|Encainide(DB01228)|Ethotoin(DB00754)|Flecainide(DB01195)|Fosphenytoin(DB01320)|Hexylcaine(DB00473)|Indecainide(DB00192)|Lamotrigine(DB00555)|Lidocaine(DB00281)|Mephenytoin(DB00532)|Mexiletine(DB00379)|Mibefradil(DB01388)|Moricizine(DB00680)|Oxcarbazepine(DB00776)|Phenytoin(DB00252)|Prilocaine(DB00750)|Procainamide(DB01035)|Propafenone(DB01182)|Quinidine(DB00908)|Riluzole(DB00740)|Tocainide(DB01056)|Verapamil(DB00661)	GTGACACTGTCATAGGAGGGT	0.602000													3	44					0	0	1	0	0
ZNF285	26974	broad.mit.edu	37	19	44891618	44891618	+	Silent	SNP	G	G	A			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr19:44891618G>A	ENST00000330997.4	-	4	853	c.789C>T	c.(787-789)gaC>gaT	p.D263D	ZNF285_ENST00000544719.2_Silent_p.D263D|CTC-512J12.6_ENST00000588212.1_Intron|ZNF285_ENST00000591679.1_Silent_p.D270D	NM_152354.3	NP_689567.3			zinc finger protein 285											breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(15)|ovary(2)|prostate(5)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	44						TTCCATACTGGTCACATTTAT	0.433000													35	81					0	0	1	0	0
WASH3P	374666	broad.mit.edu	37	15	102516424	102516424	+	RNA	SNP	G	G	T			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr15:102516424G>T	ENST00000557932.1	+	0	1372																		p.P449P(4)		central_nervous_system(1)|endometrium(6)|kidney(11)|prostate(5)|stomach(1)|urinary_tract(1)	25						TGCCGCCACCGCAGCAGCCAC	0.647000													7	68					0.000157383	0.00017403	1	1	0
LRP1B	53353	broad.mit.edu	37	2	141291668	141291668	+	Missense_Mutation	SNP	G	G	T	rs151047433		TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr2:141291668G>T	ENST00000389484.3	-	47	8655	c.7684C>A	c.(7684-7686)Cgc>Agc	p.R2562S		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	2562	LDL-receptor class A 12.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding	p.R2562C(1)		NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		ATGCAGCGGCGATTATAGCAT	0.363000										TSP Lung(27;0.18)			5	31					1.23904e-05	1.43929e-05	1	1	0
LRCH3	84859	broad.mit.edu	37	3	197518157	197518157	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr3:197518157C>T	ENST00000438796.2	+	1	52	c.8C>T	c.(7-9)gCc>gTc	p.A3V	LRCH3_ENST00000334859.4_Missense_Mutation_p.A3V|LRCH3_ENST00000441090.2_Missense_Mutation_p.A3V|LRCH3_ENST00000414675.2_Missense_Mutation_p.A3V|LRCH3_ENST00000425562.2_Missense_Mutation_p.A3V			Q96II8	LRCH3_HUMAN	leucine-rich repeats and calponin homology (CH) domain containing 3	3						extracellular region				breast(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(13)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29	all_cancers(143;1.15e-09)|Ovarian(172;0.0418)|Breast(254;0.0976)		Epithelial(36;4.82e-24)|all cancers(36;3.61e-22)|OV - Ovarian serous cystadenocarcinoma(49;7.08e-19)|LUSC - Lung squamous cell carcinoma(58;6.94e-07)|Lung(62;9.92e-07)	GBM - Glioblastoma multiforme(93;0.119)		GAAATGGCGGCCGCGGGCTTG	0.716000													6	9					0	0	1	0	0
ZNF521	25925	broad.mit.edu	37	18	22807567	22807567	+	Silent	SNP	G	G	A	rs145068263		TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr18:22807567G>A	ENST00000361524.3	-	4	463	c.315C>T	c.(313-315)tgC>tgT	p.C105C	ZNF521_ENST00000538137.2_Silent_p.C105C|ZNF521_ENST00000584787.1_5'UTR	NM_015461.2	NP_056276.1	Q96K83	ZN521_HUMAN	zinc finger protein 521	105					cell differentiation|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein domain specific binding|zinc ion binding			NS(1)|breast(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(21)|lung(97)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	149	all_cancers(21;0.0025)|all_epithelial(16;3.62e-05)|Ovarian(20;0.0991)					CTCCAAAATCGCAACCTTCTC	0.517000			T	PAX5	ALL								4	59					0	0	1	0	0
ZMYND8	23613	broad.mit.edu	37	20	45875019	45875019	+	Missense_Mutation	SNP	G	G	C			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr20:45875019G>C	ENST00000311275.7	-	14	2210	c.1957C>G	c.(1957-1959)Cca>Gca	p.P653A	ZMYND8_ENST00000352431.2_Missense_Mutation_p.P673A|ZMYND8_ENST00000355972.4_Missense_Mutation_p.P653A|ZMYND8_ENST00000262975.4_Missense_Mutation_p.P653A|ZMYND8_ENST00000540497.1_Missense_Mutation_p.P601A|ZMYND8_ENST00000468376.2_5'UTR|ZMYND8_ENST00000536340.1_Missense_Mutation_p.P680A|ZMYND8_ENST00000396281.4_Missense_Mutation_p.P653A|ZMYND8_ENST00000458360.2_Missense_Mutation_p.P648A|ZMYND8_ENST00000446994.2_Missense_Mutation_p.P590A|ZMYND8_ENST00000461685.1_Missense_Mutation_p.P673A|ZMYND8_ENST00000471951.2_Missense_Mutation_p.P673A|ZMYND8_ENST00000360911.3_Missense_Mutation_p.P648A|ZMYND8_ENST00000372023.3_Missense_Mutation_p.P648A			Q9ULU4	PKCB1_HUMAN	zinc finger, MYND-type containing 8	653							protein binding|zinc ion binding			NS(1)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(11)|lung(22)|ovary(1)|prostate(3)|skin(2)|urinary_tract(8)	62			Epithelial(1;0.0289)|all cancers(1;0.0962)|OV - Ovarian serous cystadenocarcinoma(1;0.154)			TCGCTGGCTGGTGACGTGCTT	0.507000													24	83					0	0	1	0	0
ZNF488	118738	broad.mit.edu	37	10	48371096	48371096	+	Silent	SNP	C	C	T			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr10:48371096C>T	ENST00000395702.2	+	2	791	c.564C>T	c.(562-564)gcC>gcT	p.A188A	ZNF488_ENST00000586537.1_Silent_p.A81A|ZNF488_ENST00000494156.1_3'UTR			Q96MN9	ZN488_HUMAN	zinc finger protein 488	188					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(7)|ovary(2)	14						CTGCAGATGCCCTGGGGGAGC	0.537000													8	58					0	0	1	0	0
PDE3B	5140	broad.mit.edu	37	11	14666460	14666460	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr11:14666460G>A	ENST00000282096.4	+	1	1192	c.839G>A	c.(838-840)aGt>aAt	p.S280N	PDE3B_ENST00000534317.1_3'UTR|PDE3B_ENST00000455098.2_Missense_Mutation_p.S280N	NM_000922.3	NP_000913.2	Q13370	PDE3B_HUMAN	phosphodiesterase 3B, cGMP-inhibited	280					cAMP catabolic process|insulin receptor signaling pathway|negative regulation of lipid catabolic process|platelet activation	cytosol|endoplasmic reticulum|Golgi apparatus|guanyl-nucleotide exchange factor complex|integral to membrane|microsome	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cGMP-inhibited cyclic-nucleotide phosphodiesterase activity|metal ion binding|protein kinase B binding			NS(1)|breast(1)|endometrium(5)|kidney(3)|large_intestine(6)|lung(15)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	39						CGACTGTCCAGTGCCGCCGAA	0.587000													17	56					0	0	1	0	0
LIN9	286826	broad.mit.edu	37	1	226421197	226421197	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr1:226421197C>T	ENST00000328205.5	-	13	1866	c.1321G>A	c.(1321-1323)Gca>Aca	p.A441T	LIN9_ENST00000366801.1_Missense_Mutation_p.A390T|LIN9_ENST00000481685.1_Missense_Mutation_p.A406T	NM_173083.3	NP_775106.2	Q5TKA1	LIN9_HUMAN	lin-9 homolog (C. elegans)	425					cell cycle|DNA replication	nucleoplasm				breast(3)|endometrium(4)|kidney(2)|large_intestine(6)|lung(9)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	28	Breast(184;0.158)			GBM - Glioblastoma multiforme(131;0.131)		GGCTGATCTGCAGGCTGGAGC	0.483000													16	97					0	0	1	0	0
INSRR	3645	broad.mit.edu	37	1	156816537	156816537	+	Silent	SNP	G	G	A			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr1:156816537G>A	ENST00000368195.3	-	8	1980	c.1584C>T	c.(1582-1584)aaC>aaT	p.N528N	NTRK1_ENST00000392302.2_Intron	NM_014215.2	NP_055030.1	P14616	INSRR_HUMAN	insulin receptor-related receptor	528	Fibronectin type-III 1.				protein autophosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|insulin receptor substrate binding|metal ion binding|phosphatidylinositol 3-kinase binding|transmembrane receptor protein tyrosine kinase activity			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(13)|ovary(7)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)	42	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					GCTCTGTGGCGTTCTGGAATG	0.617000													6	41					0	0	1	0	0
OPN5	221391	broad.mit.edu	37	6	47749807	47749807	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr6:47749807C>T	ENST00000489301.2	+	1	90	c.5C>T	c.(4-6)gCg>gTg	p.A2V	OPN5_ENST00000371211.2_Missense_Mutation_p.A2V|OPN5_ENST00000393699.2_Missense_Mutation_p.A2V			Q6U736	OPN5_HUMAN	opsin 5	2					phototransduction|protein-chromophore linkage|visual perception	integral to membrane	G-protein coupled receptor activity|photoreceptor activity			endometrium(1)|large_intestine(3)|lung(14)|ovary(1)|prostate(2)|skin(6)|upper_aerodigestive_tract(2)	29						AACAGAATGGCGTTAAATCAC	0.498000													11	71					0	0	1	0	0
LOC101927079	101927079	broad.mit.edu	37	15	22332492	22332492	+	RNA	SNP	A	A	C			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr15:22332492A>C	ENST00000558896.1	+	0	299																											TATTTCTCTTATTACTATTTT	0.383000													4	163					0	0	1	0	0
OXA1L	5018	broad.mit.edu	37	14	23235884	23235884	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr14:23235884G>A	ENST00000285848.5	+	1	154	c.154G>A	c.(154-156)Gca>Aca	p.A52T		NM_005015.3	NP_005006.3	Q15070	OXA1L_HUMAN	oxidase (cytochrome c) assembly 1-like	0					aerobic respiration|mitochondrial proton-transporting ATP synthase complex assembly|mitochondrial respiratory chain complex I assembly|negative regulation of ATPase activity|negative regulation of oxidoreductase activity|protein insertion into membrane|protein tetramerization	integral to mitochondrial membrane|mitochondrial respiratory chain|protein complex	protein homodimerization activity|ribosome binding			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(5)|skin(2)	19	all_cancers(95;8.44e-05)			GBM - Glioblastoma multiforme(265;0.0096)		CTGCGCAGGCGCAAAAGCAAG	0.582000													14	124					0	0	1	0	0
MT-ND4	4538	broad.mit.edu	37	MT	11711	11711	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chrM:11711G>A	ENST00000361381.2	+	1	952	c.952G>A	c.(952-954)Gcc>Acc	p.318_318insT						mitochondrially encoded NADH dehydrogenase 4											breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|prostate(1)	13						TTCTCATAATCGCCCACGGAC	0.483000													9	4					0	0	1	0	0
CPE	1363	broad.mit.edu	37	4	166408697	166408697	+	Missense_Mutation	SNP	A	A	T			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr4:166408697A>T	ENST00000402744.4	+	6	1361	c.1081A>T	c.(1081-1083)Aac>Tac	p.N361Y		NM_001873.2	NP_001864.1	P16870	CBPE_HUMAN	carboxypeptidase E	361					cardiac left ventricle morphogenesis|neuropeptide signaling pathway|protein modification process	extracellular region|nucleus|plasma membrane	metallocarboxypeptidase activity|protein binding|zinc ion binding			endometrium(2)|large_intestine(10)|lung(9)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	26	all_hematologic(180;0.221)	Prostate(90;0.0962)|Melanoma(52;0.18)		GBM - Glioblastoma multiforme(119;0.137)	Glucagon recombinant(DB00040)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	CTGGGAGGATAACAAAAACTC	0.443000													3	32					0	0	1	0	0
ZNF619	285267	broad.mit.edu	37	3	40528959	40528959	+	Nonsense_Mutation	SNP	G	G	T			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr3:40528959G>T	ENST00000447116.2	+	6	1385	c.1078G>T	c.(1078-1080)Gaa>Taa	p.E360*	ZNF619_ENST00000522736.1_Nonsense_Mutation_p.E311*|ZNF619_ENST00000456778.1_Nonsense_Mutation_p.E276*|ZNF619_ENST00000520737.1_3'UTR|ZNF619_ENST00000432264.2_Nonsense_Mutation_p.E320*|ZNF619_ENST00000429348.2_Nonsense_Mutation_p.E320*|ZNF619_ENST00000521353.1_Nonsense_Mutation_p.E360*|ZNF619_ENST00000314686.5_Nonsense_Mutation_p.E304*	NM_001145082.2	NP_001138554.1	E9PCD9	E9PCD9_HUMAN	zinc finger protein 619	360					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding			breast(1)|cervix(1)|endometrium(2)|large_intestine(7)|lung(6)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	21				KIRC - Kidney renal clear cell carcinoma(284;0.0525)|Kidney(284;0.0661)		TAAATGTAAGGAATGTGGGAA	0.423000													16	33					5.01169e-05	5.70638e-05	1	1	0
OR4N4	283694	broad.mit.edu	37	15	22383265	22383265	+	Missense_Mutation	SNP	T	T	A			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr15:22383265T>A	ENST00000328795.4	+	1	884	c.793T>A	c.(793-795)Tta>Ata	p.L265I	RP11-69H14.6_ENST00000558896.1_RNA	NM_001005241.2	NP_001005241.2	Q8N0Y3	OR4N4_HUMAN	olfactory receptor, family 4, subfamily N, member 4	265					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(3)|kidney(3)|large_intestine(6)|lung(19)|ovary(4)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	40		all_cancers(20;1.94e-20)|all_epithelial(15;3.94e-18)|Lung NSC(15;8.53e-15)|all_lung(15;2.87e-14)|Breast(32;0.00519)|Colorectal(260;0.101)	GBM - Glioblastoma multiforme(6;0.124)	all cancers(64;1.64e-11)|Epithelial(43;5.81e-10)|BRCA - Breast invasive adenocarcinoma(123;0.000255)|Kidney(6;0.00736)|KIRC - Kidney renal clear cell carcinoma(6;0.0135)|GBM - Glioblastoma multiforme(186;0.0963)		TTTCAGGGCCTTACCAGCTGA	0.433000													21	255					0	0	1	0	0
CSRNP2	81566	broad.mit.edu	37	12	51457744	51457744	+	Missense_Mutation	SNP	A	A	C			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr12:51457744A>C	ENST00000228515.1	-	5	1714	c.1417T>G	c.(1417-1419)Tca>Gca	p.S473A		NM_030809.2	NP_110436.1	Q9H175	CSRN2_HUMAN	cysteine-serine-rich nuclear protein 2	473					apoptosis|positive regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(5)|urinary_tract(1)	14						CCCACCTCTGATTTACAGAGG	0.527000													23	73					0	0	1	0	0
GPR45	11250	broad.mit.edu	37	2	105858611	105858611	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr2:105858611G>A	ENST00000258456.1	+	1	412	c.296G>A	c.(295-297)cGc>cAc	p.R99H		NM_007227.3	NP_009158.3	Q9Y5Y3	GPR45_HUMAN	G protein-coupled receptor 45	99						integral to membrane|plasma membrane	G-protein coupled receptor activity|protein binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(8)|lung(10)|ovary(1)|prostate(1)|stomach(1)|urinary_tract(1)	28						ATCACCGTGCGCTGGCACTTT	0.632000													35	138					0	0	1	0	0
DHX57	90957	broad.mit.edu	37	2	39085937	39085937	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr2:39085937C>A	ENST00000295373.6	-	6	1579	c.1453G>T	c.(1453-1455)Ggt>Tgt	p.G485C	DHX57_ENST00000479345.2_5'UTR	NM_198963.1	NP_945314.1	Q6P158	DHX57_HUMAN	DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57	485							ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding|zinc ion binding			NS(2)|breast(3)|central_nervous_system(1)|endometrium(9)|kidney(2)|large_intestine(15)|lung(20)|ovary(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	62		all_hematologic(82;0.248)				GGTGCAGGACCGTCATCCTCA	0.378000													12	31					2.27111e-07	2.74924e-07	1	1	0
LRP2	4036	broad.mit.edu	37	2	170101363	170101363	+	Silent	SNP	G	G	A			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr2:170101363G>A	ENST00000263816.3	-	22	3555	c.3270C>T	c.(3268-3270)aaC>aaT	p.N1090N	LRP2_ENST00000443831.1_Silent_p.N953N	NM_004525.2	NP_004516.2	P98164	LRP2_HUMAN	low density lipoprotein receptor-related protein 2	1090	LDL-receptor class A 9.				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			biliary_tract(1)|breast(16)|central_nervous_system(6)|cervix(2)|endometrium(24)|haematopoietic_and_lymphoid_tissue(2)|kidney(17)|large_intestine(70)|liver(1)|lung(117)|ovary(19)|pancreas(1)|prostate(2)|skin(17)|upper_aerodigestive_tract(7)|urinary_tract(13)	315				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	CCACACAGTCGTTGCGTTTGT	0.512000													31	134					0	0	1	0	0
MUC5B	727897	broad.mit.edu	37	11	1272788	1272788	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr11:1272788C>T	ENST00000447027.1	+	31	14745	c.14687C>T	c.(14686-14688)aCg>aTg	p.T4896M	MUC5B_ENST00000529681.1_Missense_Mutation_p.T4893M			Q9HC84	MUC5B_HUMAN	mucin 5B, oligomeric mucus/gel-forming	4893	Thr-rich.				cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding			cervix(2)|endometrium(36)|kidney(9)|lung(89)|urinary_tract(1)	137		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		ACTGCCTCCACGGTTCCCAGC	0.662000													4	27					0	0	1	0	0
FREM1	158326	broad.mit.edu	37	9	14848737	14848737	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr9:14848737C>A	ENST00000380881.4	-	8	2005	c.1190G>T	c.(1189-1191)aGg>aTg	p.R397M	FREM1_ENST00000422223.2_Missense_Mutation_p.R396M|FREM1_ENST00000380880.3_Missense_Mutation_p.R396M			Q5H8C1	FREM1_HUMAN	FRAS1 related extracellular matrix 1	396					cell communication|multicellular organismal development	basement membrane|integral to membrane	metal ion binding|sugar binding			breast(3)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(40)|ovary(4)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	100				GBM - Glioblastoma multiforme(50;3.53e-06)		AGGTGCACTCCTTTCAAAGAA	0.438000													6	29					8.12818e-05	9.07516e-05	1	1	0
DPF3	8110	broad.mit.edu	37	14	73138002	73138002	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr14:73138002C>T	ENST00000541685.1	-	9	928	c.916G>A	c.(916-918)Gca>Aca	p.A306T	DPF3_ENST00000546183.1_Missense_Mutation_p.A316T|DPF3_ENST00000557704.1_5'UTR|DPF3_ENST00000556509.1_Intron	NM_012074.3	NP_036206.3	Q92784	DPF3_HUMAN	D4, zinc and double PHD fingers, family 3	135					chromatin modification|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nBAF complex	nucleic acid binding|zinc ion binding			central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(13)|ovary(1)	22				BRCA - Breast invasive adenocarcinoma(234;0.00649)|OV - Ovarian serous cystadenocarcinoma(108;0.0654)		GTACGTGCTGCGGCCGCTGCC	0.502000													6	59					0	0	1	0	0
TMEM123	114908	broad.mit.edu	37	11	102272284	102272284	+	Silent	SNP	A	A	T			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr11:102272284A>T	ENST00000398136.2	-	4	1008	c.588T>A	c.(586-588)atT>atA	p.I196I	TMEM123_ENST00000361236.3_Silent_p.I177I|TMEM123_ENST00000532161.1_Silent_p.I108I	NM_052932.2	NP_443164.2	Q8N131	PORIM_HUMAN	transmembrane protein 123	196					oncosis	external side of plasma membrane|integral to membrane	receptor activity			breast(3)|kidney(1)|large_intestine(1)|lung(3)|urinary_tract(1)	9	all_cancers(8;0.00027)|all_epithelial(12;0.0021)|Lung NSC(15;0.227)	Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0033)	Epithelial(9;0.0314)|Lung(13;0.109)|all cancers(10;0.12)|LUSC - Lung squamous cell carcinoma(19;0.151)	BRCA - Breast invasive adenocarcinoma(274;0.0149)		TTCGATACCGAATGCCTCTTC	0.348000													3	33					0	0	1	0	0
KCNU1	157855	broad.mit.edu	37	8	36663852	36663852	+	Silent	SNP	C	C	A			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr8:36663852C>A	ENST00000399881.3	+	5	571	c.534C>A	c.(532-534)acC>acA	p.T178T		NM_001031836.2	NP_001027006.2	A8MYU2	KCNU1_HUMAN	potassium channel, subfamily U, member 1	178						voltage-gated potassium channel complex	binding|large conductance calcium-activated potassium channel activity|voltage-gated potassium channel activity			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(8)|kidney(1)|large_intestine(9)|lung(31)|ovary(1)|urinary_tract(1)	57				KIRC - Kidney renal clear cell carcinoma(67;0.0504)|Kidney(114;0.0634)		ACATCTTTACCATCCCACCAA	0.353000													3	7					0.115264	0.118351	1	1	0
GLRB	2743	broad.mit.edu	37	4	158060005	158060005	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr4:158060005G>T	ENST00000264428.4	+	7	925	c.655G>T	c.(655-657)Gat>Tat	p.D219Y	GLRB_ENST00000541722.1_Missense_Mutation_p.D219Y|GLRB_ENST00000509282.1_Missense_Mutation_p.D219Y|GLRB_ENST00000512619.1_Intron	NM_000824.4	NP_000815.1	P48167	GLRB_HUMAN	glycine receptor, beta	219					nervous system development|neuropeptide signaling pathway|startle response	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	extracellular-glycine-gated chloride channel activity|protein binding|receptor activity			central_nervous_system(1)|endometrium(3)|large_intestine(11)|lung(6)|skin(5)|upper_aerodigestive_tract(1)	27	all_hematologic(180;0.24)	Renal(120;0.0458)		KIRC - Kidney renal clear cell carcinoma(143;0.0564)|COAD - Colon adenocarcinoma(41;0.0642)|Kidney(143;0.0707)	Glycine(DB00145)	GCAGTCAGGAGATCCTGTGCA	0.284000													8	37					1.58986e-06	1.88489e-06	1	1	0
CPE	1363	broad.mit.edu	37	4	166408698	166408698	+	Missense_Mutation	SNP	A	A	T			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr4:166408698A>T	ENST00000402744.4	+	6	1362	c.1082A>T	c.(1081-1083)aAc>aTc	p.N361I		NM_001873.2	NP_001864.1	P16870	CBPE_HUMAN	carboxypeptidase E	361					cardiac left ventricle morphogenesis|neuropeptide signaling pathway|protein modification process	extracellular region|nucleus|plasma membrane	metallocarboxypeptidase activity|protein binding|zinc ion binding			endometrium(2)|large_intestine(10)|lung(9)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	26	all_hematologic(180;0.221)	Prostate(90;0.0962)|Melanoma(52;0.18)		GBM - Glioblastoma multiforme(119;0.137)	Glucagon recombinant(DB00040)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	TGGGAGGATAACAAAAACTCC	0.443000													3	31					0	0	1	0	0
INPPL1	3636	broad.mit.edu	37	11	71949338	71949338	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr11:71949338G>T	ENST00000541756.1	+	28	3922	c.2992G>T	c.(2992-2994)Ggg>Tgg	p.G998W	INPPL1_ENST00000538751.1_Missense_Mutation_p.G998W|INPPL1_ENST00000298229.2_Missense_Mutation_p.G1240W			O15357	SHIP2_HUMAN	inositol polyphosphate phosphatase-like 1	1240	Pro-rich.				actin filament organization|cell adhesion|endocytosis	actin cortical patch|cytosol	actin binding|SH2 domain binding|SH3 domain binding			breast(2)|endometrium(9)|kidney(1)|large_intestine(7)|lung(12)|ovary(1)|pancreas(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	44						GGAGGAGGCTGGGGTGCAGGA	0.637000											OREG0021191	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	10	46					2.27111e-07	2.74924e-07	1	1	0
SYNE1	23345	broad.mit.edu	37	6	152623099	152623099	+	Silent	SNP	G	G	A			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr6:152623099G>A	ENST00000367255.5	-	92	18047	c.17446C>T	c.(17446-17448)Ctg>Ttg	p.L5816L	SYNE1_ENST00000423061.1_Silent_p.L5745L|SYNE1_ENST00000448038.1_Silent_p.L5745L|SYNE1_ENST00000341594.5_Silent_p.L5428L|SYNE1_ENST00000356820.4_Silent_p.L340L|SYNE1_ENST00000265368.4_Silent_p.L5816L	NM_182961.3	NP_892006.3	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	5816					cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			NS(3)|biliary_tract(1)|breast(17)|central_nervous_system(21)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(4)|kidney(16)|large_intestine(138)|liver(1)|lung(190)|ovary(11)|pancreas(5)|prostate(12)|skin(20)|stomach(3)|upper_aerodigestive_tract(33)|urinary_tract(19)	524		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		GTCACCGTCAGCAGCATGGTG	0.597000										HNSCC(10;0.0054)			15	28					0	0	1	0	0
CXCR6	10663	broad.mit.edu	37	3	45988860	45988860	+	Missense_Mutation	SNP	G	G	A	rs141955108		TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr3:45988860G>A	ENST00000458629.1	+	1	2350	c.887G>A	c.(886-888)cGa>cAa	p.R296Q	CXCR6_ENST00000304552.4_Missense_Mutation_p.R296Q|FYCO1_ENST00000296137.2_Intron|CXCR6_ENST00000457814.1_Missense_Mutation_p.R296Q|CXCR6_ENST00000438735.1_Missense_Mutation_p.R296Q|FYCO1_ENST00000438446.1_Intron|FYCO1_ENST00000535325.1_Intron			O00574	CXCR6_HUMAN	chemokine (C-X-C motif) receptor 6	296					viral genome replication	integral to plasma membrane	coreceptor activity			central_nervous_system(1)|endometrium(1)|kidney(3)|lung(1)|prostate(1)|skin(1)	8				BRCA - Breast invasive adenocarcinoma(193;0.00113)|KIRC - Kidney renal clear cell carcinoma(197;0.0172)|Kidney(197;0.0203)		CTGAAGTTTCGAAAGAACTTC	0.473000													5	39					0	0	1	0	0
SCARF1	8578	broad.mit.edu	37	17	1538814	1538814	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr17:1538814C>T	ENST00000571272.1	-	11	1740	c.1694G>A	c.(1693-1695)cGc>cAc	p.R565H	SCARF1_ENST00000263071.4_Silent_p.P577P|SCARF1_ENST00000348987.3_Silent_p.P491P			Q14162	SREC_HUMAN	scavenger receptor class F, member 1	0	Pro/Ser-rich.				cell adhesion|neuron remodeling|positive regulation of axon regeneration|receptor-mediated endocytosis	integral to membrane	low-density lipoprotein particle binding|scavenger receptor activity			cervix(1)|endometrium(3)|kidney(2)|lung(9)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	20				UCEC - Uterine corpus endometrioid carcinoma (25;0.0822)		TGGAGGTGCGCGGGATGGCGA	0.672000													18	74					0	0	1	0	0
KDR	3791	broad.mit.edu	37	4	55981108	55981108	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr4:55981108C>A	ENST00000263923.4	-	5	886	c.591G>T	c.(589-591)atG>atT	p.M197I		NM_002253.2	NP_002244.1	P35968	VGFR2_HUMAN	kinase insert domain receptor (a type III receptor tyrosine kinase)	197	Ig-like C2-type 2.				angiogenesis|cell differentiation|interspecies interaction between organisms|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of focal adhesion assembly|positive regulation of positive chemotaxis|regulation of cell shape	integral to plasma membrane	ATP binding|growth factor binding|Hsp90 protein binding|integrin binding|receptor signaling protein tyrosine kinase activity|vascular endothelial growth factor receptor activity			NS(1)|breast(3)|central_nervous_system(4)|endometrium(2)|haematopoietic_and_lymphoid_tissue(6)|kidney(8)|large_intestine(16)|lung(71)|ovary(2)|prostate(2)|skin(10)|soft_tissue(4)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	135	all_cancers(7;0.0255)|all_lung(4;0.00175)|Lung NSC(11;0.00384)|all_epithelial(27;0.034)|Glioma(25;0.08)|all_neural(26;0.101)		Epithelial(7;0.189)		Sorafenib(DB00398)|Sunitinib(DB01268)	CACAGAAGACCATGCCAGCAT	0.383000			Mis		"""NSCLC, angiosarcoma"""					TSP Lung(20;0.16)			3	27					0.004672	0.00506868	1	1	0
SCAND3	114821	broad.mit.edu	37	6	28542473	28542473	+	Missense_Mutation	SNP	T	T	G			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr6:28542473T>G	ENST00000452236.2	-	3	2626	c.2009A>C	c.(2008-2010)aAa>aCa	p.K670T		NM_052923.1	NP_443155.1	Q6R2W3	SCND3_HUMAN	SCAN domain containing 3	670					DNA integration|viral reproduction	nucleus	DNA binding|protein dimerization activity|sequence-specific DNA binding transcription factor activity			NS(3)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(14)|liver(1)|lung(29)|ovary(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(3)	71						CTTTAGCATTTTGGAAGGTTT	0.423000													17	121					0	0	1	0	0
ELP2	55250	broad.mit.edu	37	18	33734899	33734899	+	Silent	SNP	C	C	T			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr18:33734899C>T	ENST00000358232.6	+	12	1275	c.1212C>T	c.(1210-1212)atC>atT	p.I404I	ELP2_ENST00000423854.2_Silent_p.I334I|ELP2_ENST00000351393.6_Silent_p.I378I|ELP2_ENST00000542824.1_Silent_p.I334I|ELP2_ENST00000442325.2_Silent_p.I469I|ELP2_ENST00000350494.6_Silent_p.I399I|ELP2_ENST00000542050.1_3'UTR	NM_018255.2	NP_060725.1	Q6IA86	ELP2_HUMAN	elongator acetyltransferase complex subunit 2	404					regulation of transcription from RNA polymerase II promoter	Golgi apparatus|transcription elongation factor complex				NS(1)|breast(4)|kidney(2)|large_intestine(8)|lung(10)|ovary(1)|skin(2)|urinary_tract(2)	30						AATTTATTATCACTGTTGGTA	0.388000													7	42					0	0	1	0	0
SPRY3	10251	broad.mit.edu	37	X	155003947	155003947	+	Silent	SNP	G	G	C			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chrX:155003947G>C	ENST00000302805.2	+	2	845	c.414G>C	c.(412-414)ggG>ggC	p.G138G		NM_005840.1	NP_005831.1	O43610	SPY3_HUMAN	sprouty homolog 3 (Drosophila)	138					multicellular organismal development|regulation of signal transduction	cytoplasm|membrane		p.G138G(1)				all_cancers(53;1.86e-17)|all_epithelial(53;2.71e-11)|all_lung(58;1.84e-07)|Lung NSC(58;5.62e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)					AATCTGCAGGGCACCCTAGTG	0.607000													17	67					0	0	1	0	0
ZFP82	284406	broad.mit.edu	37	19	36884215	36884215	+	Missense_Mutation	SNP	A	A	G			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr19:36884215A>G	ENST00000392161.3	-	5	1269	c.1027T>C	c.(1027-1029)Tgc>Cgc	p.C343R	ZFP82_ENST00000392171.1_Missense_Mutation_p.C343R	NM_133466.2	NP_597723.1	Q8N141	ZFP82_HUMAN	ZFP82 zinc finger protein	343					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(7)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	25						GCCTTCCCGCATTCCTTACAT	0.423000													9	90					0	0	1	0	0
RP11-344E13.3	0	broad.mit.edu	37	17	20805603	20805603	+	RNA	SNP	G	G	A			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr17:20805603G>A	ENST00000577537.1	+	0	787				RP11-344E13.3_ENST00000583962.1_RNA|RP11-344E13.3_ENST00000417232.2_RNA|RP11-344E13.3_ENST00000577860.1_RNA|RP11-344E13.3_ENST00000439794.2_RNA																							GGCCTTCTACGCCCATTACTG	0.567000													8	69					0	0	1	0	0
EXT2	2132	broad.mit.edu	37	11	44165857	44165857	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr11:44165857C>G	ENST00000358681.4	+	8	1400	c.1234C>G	c.(1234-1236)Ctg>Gtg	p.L412V	EXT2_ENST00000533608.1_Intron|EXT2_ENST00000395673.3_Intron|EXT2_ENST00000343631.3_Intron	NM_001178083.1	NP_001171554.1	Q93063	EXT2_HUMAN	exostosin glycosyltransferase 2	406					glycosaminoglycan biosynthetic process|heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process|ossification|signal transduction	Golgi membrane|integral to membrane|intrinsic to endoplasmic reticulum membrane	glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity|heparan sulfate N-acetylglucosaminyltransferase activity|N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity|protein heterodimerization activity			breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|lung(17)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)	32						AATGAACTCCCTGATCTGGCC	0.473000			"""Mis, N, F, S"""			"""exostoses, osteosarcoma"""			Hereditary Multiple Exostoses				28	98					0	0	1	0	0
UNC5B	219699	broad.mit.edu	37	10	73051404	73051404	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr10:73051404G>T	ENST00000335350.6	+	10	1926	c.1510G>T	c.(1510-1512)Ggg>Tgg	p.G504W	UNC5B_ENST00000373192.4_Missense_Mutation_p.G493W	NM_170744.4	NP_734465.2	Q8IZJ1	UNC5B_HUMAN	unc-5 homolog B (C. elegans)	504					apoptosis|axon guidance|regulation of apoptosis	integral to membrane				breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(8)|lung(17)|ovary(4)|prostate(4)|skin(4)	49						TGACCTGCTGGGGGTCTTGCC	0.657000													28	85					1.2476e-16	1.63038e-16	1	1	0
ARPC1B	10095	broad.mit.edu	37	7	98984357	98984357	+	Silent	SNP	C	C	T	rs144704984		TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr7:98984357C>T	ENST00000451682.1	+	5	423	c.114C>T	c.(112-114)agC>agT	p.S38S	ARPC1B_ENST00000252725.5_Silent_p.S38S|ARPC1B_ENST00000474880.1_3'UTR|ARPC1A_ENST00000432884.2_3'UTR			O15143	ARC1B_HUMAN	actin related protein 2/3 complex, subunit 1B, 41kDa	38					cellular component movement|regulation of actin filament polymerization	Arp2/3 protein complex|cytoplasm	actin binding|structural constituent of cytoskeleton			central_nervous_system(1)|endometrium(2)|large_intestine(5)|liver(2)|lung(1)	11	all_cancers(62;3.49e-09)|all_epithelial(64;2.57e-10)|Lung NSC(181;0.0053)|all_lung(186;0.00895)|Esophageal squamous(72;0.0166)		STAD - Stomach adenocarcinoma(171;0.215)			ATGAAAAGAGCGGTGCCAAAT	0.572000													19	146					0	0	1	0	0
SACS	26278	broad.mit.edu	37	13	23909353	23909353	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr13:23909353C>T	ENST00000382298.3	-	10	9250	c.8662G>A	c.(8662-8664)Gca>Aca	p.A2888T	SACS_ENST00000402364.1_Missense_Mutation_p.A2138T|SACS_ENST00000382292.3_Missense_Mutation_p.A2888T	NM_014363.4	NP_055178.3	Q9NZJ4	SACS_HUMAN	spastic ataxia of Charlevoix-Saguenay (sacsin)	2888					cell death|negative regulation of inclusion body assembly|protein folding	axon|cell body fiber|dendrite|mitochondrion|nucleus	ATP binding|chaperone binding|Hsp70 protein binding|proteasome binding			NS(1)|biliary_tract(1)|breast(3)|central_nervous_system(2)|endometrium(22)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(54)|lung(49)|ovary(7)|pancreas(1)|prostate(4)|skin(10)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(11)	189		all_cancers(29;1.51e-22)|all_epithelial(30;7.82e-19)|all_lung(29;4.71e-18)|Lung SC(185;0.0225)|Breast(139;0.128)		all cancers(112;0.00197)|Epithelial(112;0.00854)|OV - Ovarian serous cystadenocarcinoma(117;0.0298)|Lung(94;0.189)		GAATCCAGTGCAAAGTGGCCA	0.448000													5	22					0	0	1	0	0
ALDH1L1	10840	broad.mit.edu	37	3	125828895	125828895	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr3:125828895C>T	ENST00000393434.2	-	20	2588	c.2239G>A	c.(2239-2241)Ggg>Agg	p.G747R	ALDH1L1_ENST00000472186.1_Missense_Mutation_p.G747R|ALDH1L1_ENST00000452905.2_Missense_Mutation_p.G646R|ALDH1L1_ENST00000393431.2_3'UTR|ALDH1L1_ENST00000273450.3_Missense_Mutation_p.G757R	NM_012190.3	NP_036322.2	O75891	AL1L1_HUMAN	aldehyde dehydrogenase 1 family, member L1	747	Aldehyde dehydrogenase.				10-formyltetrahydrofolate catabolic process|biosynthetic process		acyl carrier activity|cofactor binding|formyltetrahydrofolate dehydrogenase activity|hydroxymethyl-, formyl- and related transferase activity|methyltransferase activity	p.G747R(1)		NS(1)|breast(2)|central_nervous_system(3)|endometrium(2)|kidney(5)|large_intestine(10)|lung(22)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	52				GBM - Glioblastoma multiforme(114;0.0462)	Tetrahydrofolic acid(DB00116)	TTCTGCGGCCCGTGGTCGGTG	0.607000													25	45					0	0	1	0	0
ADAMTSL2	9719	broad.mit.edu	37	9	136406041	136406041	+	Silent	SNP	G	G	T			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr9:136406041G>T	ENST00000393061.3	+	7	1359	c.927G>T	c.(925-927)ctG>ctT	p.L309L	ADAMTSL2_ENST00000354484.4_Silent_p.L200L|ADAMTSL2_ENST00000393060.1_Silent_p.L200L			Q86TH1	ATL2_HUMAN	ADAMTS-like 2	200					negative regulation of transforming growth factor beta receptor signaling pathway	proteinaceous extracellular matrix	metalloendopeptidase activity|protein binding|zinc ion binding			kidney(2)|large_intestine(2)|lung(7)|ovary(2)|urinary_tract(1)	14				OV - Ovarian serous cystadenocarcinoma(145;9.31e-08)|Epithelial(140;6.62e-07)|all cancers(34;7.74e-06)		CCCACACACTGGACAAGTGTG	0.672000													6	38					0.0293803	0.0307158	1	1	0
IL18RAP	8807	broad.mit.edu	37	2	103040348	103040348	+	Nonsense_Mutation	SNP	G	G	T			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr2:103040348G>T	ENST00000264260.2	+	4	737	c.148G>T	c.(148-150)Gag>Tag	p.E50*	IL18RAP_ENST00000409369.1_Intron	NM_003853.2	NP_003844.1	O95256	I18RA_HUMAN	interleukin 18 receptor accessory protein	50					cell surface receptor linked signaling pathway|inflammatory response|innate immune response	integral to membrane	transmembrane receptor activity			autonomic_ganglia(1)|central_nervous_system(2)|endometrium(3)|kidney(4)|large_intestine(5)|lung(10)|ovary(2)|prostate(1)|skin(5)|urinary_tract(4)	37						TGATTTACCAGAGCCACAGAA	0.403000													4	22					0.150653	0.151975	1	1	0
ZNF354B	117608	broad.mit.edu	37	5	178310482	178310482	+	Silent	SNP	A	A	G			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr5:178310482A>G	ENST00000322434.3	+	5	1255	c.1029A>G	c.(1027-1029)ggA>ggG	p.G343G		NM_058230.2	NP_478137.1	Q96LW1	Z354B_HUMAN	zinc finger protein 354B	343					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|kidney(2)|large_intestine(7)|liver(2)|lung(2)|ovary(2)|stomach(3)|urinary_tract(1)	21	all_cancers(89;0.000639)|all_epithelial(37;0.000109)|Renal(175;0.000159)|Lung NSC(126;0.00199)|all_lung(126;0.00351)	all_neural(177;0.00802)|Medulloblastoma(196;0.0145)|all_hematologic(541;0.248)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CCCTTTCTGGAAGTCAGAAAA	0.398000													11	38					0	0	1	0	0
SCN11A	11280	broad.mit.edu	37	3	38988324	38988324	+	Silent	SNP	A	A	G			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr3:38988324A>G	ENST00000302328.3	-	2	540	c.342T>C	c.(340-342)ccT>ccC	p.P114P	SCN11A_ENST00000444237.2_Silent_p.P114P|SCN11A_ENST00000450244.1_Silent_p.P114P|SCN11A_ENST00000456224.3_Silent_p.P114P	NM_014139.2	NP_054858.2	Q9UI33	SCNBA_HUMAN	sodium channel, voltage-gated, type XI, alpha subunit	114					response to drug	voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(3)|biliary_tract(1)|breast(4)|cervix(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(29)|lung(29)|ovary(3)|pancreas(2)|prostate(12)|skin(14)|upper_aerodigestive_tract(5)|urinary_tract(3)	119				Kidney(284;0.00202)|KIRC - Kidney renal clear cell carcinoma(284;0.00226)	Cocaine(DB00907)	TTGAATTGAAAGGCCCAAAAA	0.383000													4	65					0	0	1	0	0
GPATCH8	23131	broad.mit.edu	37	17	42476905	42476905	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr17:42476905C>A	ENST00000434000.1	-	9	2588	c.2306G>T	c.(2305-2307)aGt>aTt	p.S769I	GPATCH8_ENST00000591680.1_Missense_Mutation_p.S847I			Q9UKJ3	GPTC8_HUMAN	G patch domain containing 8	847						intracellular	nucleic acid binding|zinc ion binding			breast(4)|endometrium(7)|kidney(6)|large_intestine(4)|liver(2)|lung(21)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	50		Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.206)		GGAATGCTCACTGCCTGAATC	0.552000													31	65					5.45727e-16	7.05153e-16	1	1	0
CLCN4	1183	broad.mit.edu	37	X	10182101	10182101	+	Nonsense_Mutation	SNP	G	G	T			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chrX:10182101G>T	ENST00000380833.4	+	11	2348	c.1957G>T	c.(1957-1959)Gaa>Taa	p.E653*	CLCN4_ENST00000380829.1_Nonsense_Mutation_p.E622*|CLCN4_ENST00000421085.2_Nonsense_Mutation_p.E559*	NM_001256944.1|NM_001830.3	NP_001243873.1|NP_001821.2	P51793	CLCN4_HUMAN	chloride channel, voltage-sensitive 4	653	CBS 1.					early endosome membrane|integral to membrane|late endosome membrane	antiporter activity|ATP binding|voltage-gated chloride channel activity			breast(1)|endometrium(5)|kidney(2)|large_intestine(12)|lung(11)|ovary(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	36						CCAGAGGAGGGAACTGATTCT	0.507000													3	5					0.150653	0.151975	1	1	0
C1orf127	148345	broad.mit.edu	37	1	11008207	11008207	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr1:11008207G>A	ENST00000377004.4	-	12	1984	c.1985C>T	c.(1984-1986)gCg>gTg	p.A662V	C1orf127_ENST00000377008.4_Missense_Mutation_p.A495V	NM_001170754.1	NP_001164225.1	B7ZLG7	B7ZLG7_HUMAN	chromosome 1 open reading frame 127	513										NS(2)|breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(7)|lung(9)|ovary(1)|prostate(2)|skin(5)	32	Ovarian(185;0.249)	Lung NSC(185;0.000226)|all_lung(284;0.000302)|Renal(390;0.000469)|Colorectal(325;0.0062)|Breast(348;0.0139)|Hepatocellular(190;0.0305)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0731)	STAD - Stomach adenocarcinoma(5;0.0224)	UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.71e-07)|COAD - Colon adenocarcinoma(227;7.79e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000305)|Kidney(185;0.000785)|KIRC - Kidney renal clear cell carcinoma(229;0.00262)|READ - Rectum adenocarcinoma(331;0.0509)		GGCATCCCTCGCTGGCAGGAT	0.647000													13	58					0	0	1	0	0
LAMA1	284217	broad.mit.edu	37	18	6956680	6956680	+	Silent	SNP	G	G	A	rs145856205		TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr18:6956680G>A	ENST00000389658.3	-	56	8142	c.8049C>T	c.(8047-8049)ccC>ccT	p.P2683P	RP11-781P6.1_ENST00000584722.1_RNA	NM_005559.3	NP_005550.2	P25391	LAMA1_HUMAN	laminin, alpha 1	2683					axon guidance|cell adhesion|cell surface receptor linked signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	extracellular space|laminin-1 complex|laminin-3 complex	extracellular matrix structural constituent|receptor binding			NS(4)|breast(7)|central_nervous_system(3)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(49)|liver(1)|lung(71)|ovary(9)|pancreas(3)|prostate(5)|skin(11)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(3)	205		Colorectal(10;0.172)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	CCTCTGCATCGGGAGCCAGCT	0.542000													6	48					0	0	1	0	0
ATOH1	474	broad.mit.edu	37	4	94750524	94750524	+	Silent	SNP	C	C	A	rs34477680		TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr4:94750524C>A	ENST00000306011.3	+	1	483	c.447C>A	c.(445-447)tcC>tcA	p.S149S		NM_005172.1	NP_005163.1	Q92858	ATOH1_HUMAN	atonal homolog 1 (Drosophila)	149					transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(2)|lung(2)|skin(1)|upper_aerodigestive_tract(1)	11		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;3.57e-07)		GGGCCCCTTCCAGCAAACAGG	0.657000													5	34					0.014758	0.0155704	1	1	0
LRP1	4035	broad.mit.edu	37	12	57605790	57605790	+	Nonsense_Mutation	SNP	C	C	T			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr12:57605790C>T	ENST00000243077.3	+	87	13805	c.13339C>T	c.(13339-13341)Cga>Tga	p.R4447*		NM_002332.2	NP_002323.2	Q07954	LRP1_HUMAN	low density lipoprotein receptor-related protein 1	4447	Interaction with MAFB (By similarity).				aorta morphogenesis|apoptotic cell clearance|negative regulation of platelet-derived growth factor receptor-beta signaling pathway|negative regulation of smooth muscle cell migration|negative regulation of Wnt receptor signaling pathway|positive regulation of cholesterol efflux|regulation of actin cytoskeleton organization|regulation of phospholipase A2 activity	coated pit|integral to plasma membrane|nucleus	apolipoprotein E binding|calcium ion binding|lipoprotein transporter activity|protein complex binding|receptor activity			NS(1)|breast(9)|central_nervous_system(3)|cervix(3)|endometrium(33)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(26)|lung(58)|ovary(10)|pancreas(2)|prostate(11)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(5)	184				BRCA - Breast invasive adenocarcinoma(357;0.0103)	Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Becaplermin(DB00102)|Coagulation Factor IX(DB00100)|Tenecteplase(DB00031)	GTATAAGCGGCGAGTCCAAGG	0.527000													8	84					0	0	1	0	0
SIGLEC12	89858	broad.mit.edu	37	19	51994907	51994907	+	Silent	SNP	G	G	A			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr19:51994907G>A	ENST00000291707.3	-	8	1831	c.1776C>T	c.(1774-1776)aaC>aaT	p.N592N	SIGLEC12_ENST00000598614.1_Silent_p.N474N	NM_053003.2	NP_443729.1	Q96PQ1	SIG12_HUMAN	sialic acid binding Ig-like lectin 12 (gene/pseudogene)	592					cell adhesion	integral to membrane	sugar binding			NS(2)|biliary_tract(1)|breast(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(8)|liver(1)|lung(23)|ovary(4)|prostate(2)|skin(8)|stomach(3)|upper_aerodigestive_tract(2)	61		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.00161)|OV - Ovarian serous cystadenocarcinoma(262;0.0102)		ACTTGGGGATGTTGATCTCGG	0.532000													33	116					0	0	1	0	0
ADCY4	196883	broad.mit.edu	37	14	24798353	24798353	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr14:24798353G>A	ENST00000310677.4	-	11	1551	c.1438C>T	c.(1438-1440)Cgt>Tgt	p.R480C	ADCY4_ENST00000396747.3_Missense_Mutation_p.R173C|ADCY4_ENST00000554068.2_Missense_Mutation_p.R480C|ADCY4_ENST00000418030.2_Missense_Mutation_p.R480C	NM_001198568.1|NM_001198592.1|NM_139247.3	NP_001185497.1|NP_001185521.1|NP_640340.2	Q8NFM4	ADCY4_HUMAN	adenylate cyclase 4	480					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	cytoplasm|integral to membrane|plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding|protein binding			cervix(1)|endometrium(1)|kidney(1)|large_intestine(10)|lung(13)|ovary(2)|pancreas(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	34				GBM - Glioblastoma multiforme(265;0.0192)		TCCAGGTAACGGGTCATCAGC	0.617000													9	55					0	0	1	0	0
LINGO1	84894	broad.mit.edu	37	15	77907402	77907402	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr15:77907402C>T	ENST00000355300.6	-	2	1021	c.847G>A	c.(847-849)Gtc>Atc	p.V283I	LINGO1_ENST00000561030.1_Missense_Mutation_p.V277I	NM_032808.5	NP_116197.4	Q96FE5	LIGO1_HUMAN	leucine rich repeat and Ig domain containing 1	283					negative regulation of axonogenesis|nerve growth factor receptor signaling pathway	integral to membrane|plasma membrane				breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(16)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	31						AGGTGGCGGACGGCCAGGTAG	0.587000													3	57					0	0	1	0	0
ARHGAP25	9938	broad.mit.edu	37	2	69043356	69043356	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr2:69043356C>A	ENST00000544262.1	+	7	1014	c.800C>A	c.(799-801)tCc>tAc	p.S267Y	ARHGAP25_ENST00000295381.3_Intron|ARHGAP25_ENST00000409030.3_Intron|ARHGAP25_ENST00000497079.1_Intron|ARHGAP25_ENST00000467265.1_Intron|ARHGAP25_ENST00000409202.3_Intron|ARHGAP25_ENST00000409220.1_Intron			P42331	RHG25_HUMAN	Rho GTPase activating protein 25	0	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			breast(3)|endometrium(5)|kidney(2)|large_intestine(11)|lung(20)|ovary(3)|prostate(1)|skin(5)|stomach(1)|urinary_tract(1)	52						CCCAGGGTCTCCTTGCTGGCA	0.438000													4	20					0.00909568	0.00977573	1	1	0
AQP7	364	broad.mit.edu	37	9	33385614	33385614	+	Missense_Mutation	SNP	A	A	T	rs140995428	by1000genomes	TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr9:33385614A>T	ENST00000541274.1	-	5	830	c.381T>A	c.(379-381)agT>agA	p.S127R	AQP7_ENST00000537089.1_3'UTR|AQP7_ENST00000539936.1_3'UTR|AQP7_ENST00000377425.4_Intron			O14520	AQP7_HUMAN	aquaporin 7	0					excretion|generation of precursor metabolites and energy	cell-cell junction|cytoplasm|integral to plasma membrane	glycerol channel activity|water channel activity			NS(1)|large_intestine(1)|lung(7)|ovary(1)|prostate(4)|skin(2)|stomach(1)	17			LUSC - Lung squamous cell carcinoma(29;0.00788)	GBM - Glioblastoma multiforme(74;0.191)		CCACAGAAAAACTCAAAGGAA	0.632000													4	79					0	0	1	0	0
TRGV8	6982	broad.mit.edu	37	7	38370493	38370493	+	RNA	SNP	G	G	T			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr7:38370493G>T	ENST00000390343.2	-	0	43																											CAAAACTCAGGTCCCACTCAA	0.502000													7	11					8.12818e-05	9.07516e-05	1	1	0
PI4K2A	55361	broad.mit.edu	37	10	99400513	99400513	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr10:99400513G>A	ENST00000370631.3	+	1	71	c.14G>A	c.(13-15)aGc>aAc	p.S5N	PI4K2A_ENST00000370649.3_Intron|PI4K2A_ENST00000555577.1_Intron	NM_018425.2	NP_060895.1	Q9BTU6	P4K2A_HUMAN	phosphatidylinositol 4-kinase type 2 alpha	5					phosphatidylinositol biosynthetic process	cytoplasm|integral to plasma membrane|membrane raft	1-phosphatidylinositol 4-kinase activity|ATP binding|magnesium ion binding			endometrium(2)|kidney(1)|large_intestine(3)|lung(3)|ovary(1)|prostate(1)|skin(1)	12		Colorectal(252;0.162)		Epithelial(162;1.24e-10)|all cancers(201;1.2e-08)		GACGAGACGAGCCCACTAGTG	0.736000													6	42					0	0	1	0	0
SLITRK1	114798	broad.mit.edu	37	13	84454780	84454780	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr13:84454780G>T	ENST00000377084.2	-	1	1748	c.863C>A	c.(862-864)aCt>aAt	p.T288N		NM_052910.1	NP_443142.1	Q96PX8	SLIK1_HUMAN	SLIT and NTRK-like family, member 1	288						integral to membrane				NS(2)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|liver(1)|lung(36)|ovary(4)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	80	Medulloblastoma(90;0.18)	Breast(118;0.212)		GBM - Glioblastoma multiforme(99;0.07)		CTTGAAAGGAGTTGGCAGGGG	0.542000													11	43					4.84862e-15	6.12737e-15	1	1	0
TMEM52	339456	broad.mit.edu	37	1	1850628	1850636	+	In_Frame_Del	DEL	AGCGGCAGG	AGCGGCAGG	-			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr1:1850628_1850636delAGCGGCAGG	ENST00000310991.3	-	1	76_84	c.69_77delCCTGCCGCT	c.(67-78)ctg>ct	p.LLPL23del		NM_178545.3	NP_848640.1	Q8NDY8	TMM52_HUMAN	transmembrane protein 52	23						integral to membrane				NS(1)|prostate(1)|stomach(1)	3	all_cancers(77;0.000708)|all_epithelial(69;0.000943)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;6.04e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Medulloblastoma(700;0.151)|Lung SC(97;0.217)		Epithelial(90;1.82e-37)|OV - Ovarian serous cystadenocarcinoma(86;2.75e-23)|GBM - Glioblastoma multiforme(42;9e-08)|Colorectal(212;3.94e-05)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.00435)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.199)		CACCTgcggcagcggcaggagcggcagga	0.766													4	2	---	---	---	---					
ODF2L	57489	broad.mit.edu	37	1	86841994	86841995	+	Frame_Shift_Ins	INS	-	-	T	rs36121011		TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr1:86841994_86841995insT	ENST00000359242.3	-	8	1012_1013	c.731_732insA	c.(730-732)agcfs	p.S244fs	ODF2L_ENST00000370566.3_Frame_Shift_Ins_p.S244fs|ODF2L_ENST00000294678.2_Frame_Shift_Ins_p.S244fs|ODF2L_ENST00000317336.7_Frame_Shift_Ins_p.S244fs|ODF2L_ENST00000394731.1_Frame_Shift_Ins_p.S113fs|ODF2L_ENST00000370567.1_Frame_Shift_Ins_p.S244fs	NM_001007022.2	NP_001007023.2	Q9ULJ1	ODF2L_HUMAN	outer dense fiber of sperm tails 2-like	244						centrosome				endometrium(2)|kidney(2)|large_intestine(10)|lung(6)|ovary(1)|pancreas(1)|skin(1)|stomach(1)	24				all cancers(265;0.0313)|Epithelial(280;0.0611)		CTTTAGATGCCTTTTTTAAAGC	0.347													2	4	---	---	---	---					
RBMXL1	494115	broad.mit.edu	37	1	89448604	89448605	+	Frame_Shift_Ins	INS	-	-	GG			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr1:89448604_89448605insGG	ENST00000399794.2	-	3	1620_1621	c.905_906insCC	c.(904-906)ctcfs	p.L302fs	CCBL2_ENST00000260508.4_Intron|CCBL2_ENST00000370491.3_Intron|CCBL2_ENST00000370485.2_Intron|CCBL2_ENST00000446900.2_Intron|RBMXL1_ENST00000321792.5_Frame_Shift_Ins_p.L302fs	NM_001162536.2	NP_001156008.1	Q96E39	RBMXL_HUMAN	RNA binding motif protein, X-linked-like 1	302	Ser-rich.						nucleotide binding|RNA binding										CACCATAAGATGGCGGGGGCCC	0.475													7	160	---	---	---	---					
CCDC13	152206	broad.mit.edu	37	3	42774410	42774410	+	Frame_Shift_Del	DEL	A	A	-			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr3:42774410delA	ENST00000310232.6	-	12	1647	c.1564delT	c.(1564-1566)ccfs	p.S522fs	CCDC13-AS1_ENST00000446950.1_RNA|CCDC13-AS1_ENST00000418161.1_RNA	NM_144719.3	NP_653320.3	Q8IYE1	CCD13_HUMAN	coiled-coil domain containing 13	522										endometrium(1)|kidney(1)|large_intestine(5)|liver(1)|lung(11)|ovary(1)|prostate(3)|skin(1)|urinary_tract(1)	25						CTGGGCAGGGAAGGCCTCGTG	0.592													2	4	---	---	---	---					
RAD54L2	23132	broad.mit.edu	37	3	51624506	51624508	+	In_Frame_Del	DEL	GAG	GAG	-			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr3:51624506_51624508delGAG	ENST00000409535.1	+	2	195_197	c.70_72delGAG	c.(70-72)del	p.E30del		NM_015106.2	NP_055921.2	Q9Y4B4	ARIP4_HUMAN	RAD54-like 2 (S. cerevisiae)	30						nucleus	ATP binding|DNA binding|helicase activity			NS(2)|breast(1)|cervix(2)|endometrium(4)|large_intestine(5)|liver(2)|lung(9)|ovary(4)|skin(2)	31				BRCA - Breast invasive adenocarcinoma(193;0.000102)|Kidney(197;0.000758)|KIRC - Kidney renal clear cell carcinoma(197;0.000896)		ggatgcggaagaggaggaggagg	0.586													2	4	---	---	---	---					
LOC285389	285389	broad.mit.edu	37	3	193776374	193776375	+	RNA	INS	-	-	G			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr3:193776374_193776375insG	ENST00000432154.1	-	0	214																											ggacgggggcaggggggagggg	0.698													2	4	---	---	---	---					
MIR1303	100302284	broad.mit.edu	37	5	154065369	154065370	+	RNA	INS	-	-	T			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr5:154065369_154065370insT	ENST00000408625.1	+	0	34_35					NR_031638.1																						caactctacaaTtttttttttt	0.470													7	18	---	---	---	---					
MAS1L	116511	broad.mit.edu	37	6	29455156	29455157	+	Frame_Shift_Del	DEL	AC	AC	-			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr6:29455156_29455157delAC	ENST00000377127.3	-	1	581_582	c.523_524delGT	c.(523-525)cfs	p.V175fs		NM_052967.1	NP_443199.1	P35410	MAS1L_HUMAN	MAS1 oncogene-like	175						cytoplasm|integral to membrane|nucleus|plasma membrane	G-protein coupled receptor activity			NS(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(7)|ovary(7)|pancreas(1)|prostate(2)|skin(2)	28						GGGGAAGAGGACACACACACAC	0.495													7	122	---	---	---	---					
SMAP1	60682	broad.mit.edu	37	6	71508370	71508370	+	Frame_Shift_Del	DEL	A	A	-			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr6:71508370delA	ENST00000370455.3	+	6	754	c.506delA	c.(505-507)gafs	p.E169fs	SMAP1_ENST00000316999.5_Frame_Shift_Del_p.E142fs|SMAP1_ENST00000370452.3_Frame_Shift_Del_p.E142fs	NM_001044305.1	NP_001037770.1	Q8IYB5	SMAP1_HUMAN	small ArfGAP 1	169					regulation of ARF GTPase activity	plasma membrane	ARF GTPase activator activity|zinc ion binding	p.K145fs*48(1)		breast(3)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(6)|prostate(1)|urinary_tract(1)	15						aaagaaaaggaaaaaaaaaag	0.289													2	4	---	---	---	---					
LOC442497	442497	broad.mit.edu	37	7	420546	420547	+	RNA	INS	-	-	G			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr7:420546_420547insG	ENST00000515213.1	+	0	282					NR_033960.1																						gggagggggcagggggacagag	0.718													2	4	---	---	---	---					
ERICH1-AS1	619343	broad.mit.edu	37	8	845007	845008	+	RNA	INS	-	-	G			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr8:845007_845008insG	ENST00000524139.1	+	0	151				ERICH1-AS1_ENST00000577187.1_RNA|ERICH1-AS1_ENST00000522092.1_RNA|ERICH1-AS1_ENST00000578889.1_RNA																							ggtggctggcagggcagggtgg	0.698													2	4	---	---	---	---					
LOC157273	157273	broad.mit.edu	37	8	9239496	9239497	+	RNA	DEL	TC	TC	-			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr8:9239496_9239497delTC	ENST00000521842.1	-	0	294																											TTCAAGCCTTTCTCTCTCTCTC	0.465													2	4	---	---	---	---					
MMP12	4321	broad.mit.edu	37	11	102738793	102738794	+	RNA	INS	-	-	T	rs35342965	by1000genomes	TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr11:102738793_102738794insT	ENST00000532855.1	-	0	727_728							P39900	MMP12_HUMAN	matrix metallopeptidase 12 (macrophage elastase)						positive regulation of epithelial cell proliferation involved in wound healing|proteolysis|wound healing, spreading of epidermal cells	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			autonomic_ganglia(1)|cervix(1)|endometrium(1)|kidney(3)|large_intestine(4)|lung(9)|prostate(5)|skin(1)|upper_aerodigestive_tract(1)	26		all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)		BRCA - Breast invasive adenocarcinoma(274;0.014)	Acetohydroxamic Acid(DB00551)	TGAGGAACAAGTGGTGCCTAAG	0.416													5	3	---	---	---	---					
GPR180	160897	broad.mit.edu	37	13	95254184	95254184	+	Translation_Start_Site	DEL	G	G	-			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr13:95254184delG	ENST00000376958.4	+	0	28					NM_180989.5	NP_851320.1	Q86V85	GP180_HUMAN	G protein-coupled receptor 180							integral to membrane				breast(1)|kidney(1)|large_intestine(3)|lung(4)|urinary_tract(1)	10	all_neural(89;0.0684)|Medulloblastoma(90;0.163)					AGACGGGCATGGGGGGGCTGC	0.771													3	3	---	---	---	---					
MGA	23269	broad.mit.edu	37	15	42003214	42003220	+	Frame_Shift_Del	DEL	CATTTTA	CATTTTA	-			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr15:42003214_42003220delCATTTTA	ENST00000219905.7	+	8	2932_2938	c.2751_2757delCATTTTA	c.(2749-2757)tcfs	p.SIL917fs	MGA_ENST00000566586.1_Frame_Shift_Del_p.SIL917fs|MGA_ENST00000570161.1_Frame_Shift_Del_p.SIL917fs|MGA_ENST00000389936.4_Frame_Shift_Del_p.SIL917fs|MGA_ENST00000545763.1_Frame_Shift_Del_p.SIL917fs	NM_001164273.1	NP_001157745.1	Q8IWI9	MGAP_HUMAN	MGA, MAX dimerization protein	917						MLL1 complex	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(4)|central_nervous_system(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(18)|lung(33)|ovary(8)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	95		all_cancers(109;0.00356)|all_epithelial(112;0.0413)|all_lung(180;0.18)|Ovarian(310;0.238)		OV - Ovarian serous cystadenocarcinoma(18;1.41e-18)|GBM - Glioblastoma multiforme(113;2.15e-06)|COAD - Colon adenocarcinoma(120;0.031)|Lung(196;0.0721)|BRCA - Breast invasive adenocarcinoma(123;0.0964)|Colorectal(105;0.0998)|LUSC - Lung squamous cell carcinoma(244;0.235)		CTTATAAATCCATTTTACCATACCCTG	0.396													9	91	---	---	---	---					
C16orf71	146562	broad.mit.edu	37	16	4796953	4796955	+	In_Frame_Del	DEL	GAG	GAG	-			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr16:4796953_4796955delGAG	ENST00000299320.5	+	8	1685_1687	c.1207_1209delGAG	c.(1207-1209)del	p.E409del	C16orf71_ENST00000590191.1_In_Frame_Del_p.E426del|RP11-127I20.7_ENST00000588099.1_RNA	NM_139170.2	NP_631909.2	Q8IYS4	CP071_HUMAN	chromosome 16 open reading frame 71	409								p.E403delE(1)		breast(1)|central_nervous_system(1)|large_intestine(4)|lung(4)|ovary(1)	11						CTCTGACAGTGAGGAGGAGGAGG	0.611													2	4	---	---	---	---					
LOC101928766	101928766	broad.mit.edu	37	17	77889491	77889492	+	RNA	INS	-	-	AGG	rs148432167	by1000genomes	TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr17:77889491_77889492insAGG	ENST00000576738.1	-	0	5109																											cagagggacgcaggaggaggag	0.649													4	5	---	---	---	---					
STK11	6794	broad.mit.edu	37	19	1207090	1207091	+	Frame_Shift_Ins	INS	-	-	A			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr19:1207090_1207091insA	ENST00000326873.7	+	1	1351_1352	c.178_179insA	c.(178-180)cggfs	p.R60fs	STK11_ENST00000585748.1_Intron	NM_000455.4	NP_000446.1	Q15831	STK11_HUMAN	serine/threonine kinase 11	60	Protein kinase.				anoikis|cell cycle arrest|energy reserve metabolic process|insulin receptor signaling pathway|positive regulation of transforming growth factor beta receptor signaling pathway|regulation of fatty acid biosynthetic process|regulation of fatty acid oxidation	cytosol|nucleus	ATP binding|magnesium ion binding|protein serine/threonine kinase activity	p.0?(20)|p.?(3)|p.G56fs*4(1)		biliary_tract(1)|breast(3)|cervix(35)|gastrointestinal_tract_(site_indeterminate)(5)|haematopoietic_and_lymphoid_tissue(7)|kidney(2)|large_intestine(14)|liver(1)|lung(219)|oesophagus(1)|ovary(4)|pancreas(6)|prostate(2)|skin(15)|small_intestine(1)|stomach(9)|testis(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	328		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;7.93e-06)|all_lung(49;1.25e-05)|Breast(49;0.000172)|Renal(1328;0.0183)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|Lung(535;0.00942)|STAD - Stomach adenocarcinoma(1328;0.18)		GGAAGGCTCTTACGGCAAGGTG	0.629		14	"""D, Mis, N, F, S"""		"""NSCLC, pancreatic"""	"""jejunal harmartoma, ovarian, testicular, pancreatic"""			Peutz-Jeghers syndrome	TSP Lung(3;<1E-08)			14	32	---	---	---	---					
MARK4	57787	broad.mit.edu	37	19	45797646	45797647	+	Frame_Shift_Ins	INS	-	-	A			TCGA-69-7763-01A-11D-2167-08	TCGA-69-7763-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8dbe8f2d-38c0-4d35-bb53-d43e759784ee	da990b8c-9ccd-4a64-811b-5a6a6177ac99	g.chr19:45797646_45797647insA	ENST00000300843.4	+	14	1831_1832	c.1534_1535insA	c.(1534-1536)cgtfs	p.R512fs	MARK4_ENST00000262891.4_Frame_Shift_Ins_p.R512fs	NM_031417.3	NP_113605.2	Q96L34	MARK4_HUMAN	MAP/microtubule affinity-regulating kinase 4	512					microtubule bundle formation|nervous system development|positive regulation of programmed cell death	centrosome|neuron projection	ATP binding|gamma-tubulin binding|microtubule binding|protein serine/threonine kinase activity|tau-protein kinase activity|ubiquitin binding			NS(1)|biliary_tract(1)|central_nervous_system(4)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(6)|lung(7)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	31		all_neural(266;0.224)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.0102)		CAGAAACACCTACGTTTGCACA	0.599													12	79	---	---	---	---