Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
ARHGAP32	9743	broad.mit.edu	37	11	128843256	128843256	+	Missense_Mutation	SNP	G	G	C			TCGA-55-8096-01A-11D-2238-08	TCGA-55-8096-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	babd96af-bc23-49ee-b8ef-541bc076c7c4	fbc4dd00-fd9b-4988-aa44-ce1598a2150b	g.chr11:128843256G>C	ENST00000310343.9	-	21	3102	c.3103C>G	c.(3103-3105)Cct>Gct	p.P1035A	ARHGAP32_ENST00000392657.3_Missense_Mutation_p.P686A|ARHGAP32_ENST00000524655.1_3'UTR|ARHGAP32_ENST00000527272.1_Missense_Mutation_p.P686A	NM_001142685.1	NP_001136157.1	A7KAX9	RHG32_HUMAN	Rho GTPase activating protein 32	1035	Poly-Pro.				cell communication|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cell cortex|cell junction|cytosol|dendritic spine|endoplasmic reticulum membrane|endosome membrane|Golgi membrane|postsynaptic density|postsynaptic membrane	GTPase activator activity|phosphatidylinositol binding			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(12)|lung(28)|ovary(3)|prostate(6)|urinary_tract(3)	60						TTTTTCGGAGGCGGTGGTGGT	0.522000													17	219					0	0	0.557998	0	0
E2F7	144455	broad.mit.edu	37	12	77449801	77449801	+	Missense_Mutation	SNP	G	G	C			TCGA-55-8096-01A-11D-2238-08	TCGA-55-8096-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	babd96af-bc23-49ee-b8ef-541bc076c7c4	fbc4dd00-fd9b-4988-aa44-ce1598a2150b	g.chr12:77449801G>C	ENST00000322886.7	-	3	438	c.203C>G	c.(202-204)aCt>aGt	p.T68S	E2F7_ENST00000416496.2_Missense_Mutation_p.T68S	NM_203394.2	NP_976328.2	Q96AV8	E2F7_HUMAN	E2F transcription factor 7	68					cell cycle	transcription factor complex	DNA binding|identical protein binding			central_nervous_system(1)|endometrium(3)|kidney(4)|large_intestine(15)|lung(14)|ovary(3)|upper_aerodigestive_tract(2)	42						CTTAACTGGAGTAATGGGATT	0.428000													17	98					0	0	0.575678	0	0
PRDM9	56979	broad.mit.edu	37	5	23527499	23527499	+	Silent	SNP	A	A	C			TCGA-55-8096-01A-11D-2238-08	TCGA-55-8096-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	babd96af-bc23-49ee-b8ef-541bc076c7c4	fbc4dd00-fd9b-4988-aa44-ce1598a2150b	g.chr5:23527499A>C	ENST00000296682.3	+	11	2484	c.2302A>C	c.(2302-2304)Agg>Cgg	p.R768R		NM_020227.2	NP_064612.2	Q9NQV7	PRDM9_HUMAN	PR domain containing 9	768					meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleoplasm	histone-lysine N-methyltransferase activity|nucleic acid binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(3)|endometrium(15)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(27)|lung(87)|ovary(6)|pancreas(2)|prostate(4)|skin(10)|upper_aerodigestive_tract(11)	172						CAGACACCAGAGGACACACAC	0.582000										HNSCC(3;0.000094)			6	354					0	0	0.248553	0	0
EMR1	2015	broad.mit.edu	37	19	6903938	6903938	+	Missense_Mutation	SNP	C	C	G			TCGA-55-8096-01A-11D-2238-08	TCGA-55-8096-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	babd96af-bc23-49ee-b8ef-541bc076c7c4	fbc4dd00-fd9b-4988-aa44-ce1598a2150b	g.chr19:6903938C>G	ENST00000312053.4	+	7	816	c.779C>G	c.(778-780)aCa>aGa	p.T260R	EMR1_ENST00000381407.5_Missense_Mutation_p.T119R|EMR1_ENST00000450315.3_Intron|EMR1_ENST00000381404.4_Missense_Mutation_p.T208R|EMR1_ENST00000250572.8_Missense_Mutation_p.T260R	NM_001974.4	NP_001965.3	Q14246	EMR1_HUMAN	egf-like module containing, mucin-like, hormone receptor-like 1	260	EGF-like 5; calcium-binding (Potential).				cell adhesion|neuropeptide signaling pathway	integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(11)|lung(31)|ovary(3)|prostate(1)|skin(8)	62	all_hematologic(4;0.166)					TTGAATTTCACAGACCAAGGA	0.458000													9	66					0	0	0.307466	0	0
CD244	51744	broad.mit.edu	37	1	160811112	160811112	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8096-01A-11D-2238-08	TCGA-55-8096-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	babd96af-bc23-49ee-b8ef-541bc076c7c4	fbc4dd00-fd9b-4988-aa44-ce1598a2150b	g.chr1:160811112G>T	ENST00000368034.4	-	3	720	c.543C>A	c.(541-543)gaC>gaA	p.D181E	CD244_ENST00000368032.2_Missense_Mutation_p.D181E|CD244_ENST00000322302.7_Intron|CD244_ENST00000368033.3_Missense_Mutation_p.D186E	NM_001166663.1|NM_001166664.1|NM_016382.3	NP_001160135.1|NP_001160136.1|NP_057466.1	Q9BZW8	CD244_HUMAN	CD244 molecule, natural killer cell receptor 2B4	186	Ig-like 2.				blood coagulation|leukocyte migration	integral to membrane|plasma membrane	protein binding|receptor activity			central_nervous_system(1)|large_intestine(3)|lung(12)|ovary(1)|urinary_tract(1)	18	all_cancers(52;2.72e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00737)			CAACCTCCTCGTCCAGGTAGG	0.517000													40	158					2.40228e-13	3.4411e-13	0.864702	1	0
NCAM2	4685	broad.mit.edu	37	21	22881276	22881276	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8096-01A-11D-2238-08	TCGA-55-8096-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	babd96af-bc23-49ee-b8ef-541bc076c7c4	fbc4dd00-fd9b-4988-aa44-ce1598a2150b	g.chr21:22881276C>A	ENST00000400546.1	+	16	2431	c.2182C>A	c.(2182-2184)Caa>Aaa	p.Q728K	NCAM2_ENST00000284894.7_Missense_Mutation_p.Q586K	NM_004540.3	NP_004531.2	O15394	NCAM2_HUMAN	neural cell adhesion molecule 2	728					neuron cell-cell adhesion	integral to membrane|plasma membrane				breast(4)|cervix(2)|endometrium(8)|kidney(6)|large_intestine(22)|liver(4)|lung(49)|ovary(4)|prostate(4)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	108		Lung NSC(9;0.195)		all cancers(11;0.00102)|OV - Ovarian serous cystadenocarcinoma(11;0.00121)|Epithelial(23;0.00147)|Colorectal(24;0.174)		CTTTATTCGGCAATGTGGGTT	0.468000													10	66					1.33987e-11	1.78649e-11	0.361761	1	0
MYOM3	127294	broad.mit.edu	37	1	24424450	24424450	+	Missense_Mutation	SNP	G	G	C			TCGA-55-8096-01A-11D-2238-08	TCGA-55-8096-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	babd96af-bc23-49ee-b8ef-541bc076c7c4	fbc4dd00-fd9b-4988-aa44-ce1598a2150b	g.chr1:24424450G>C	ENST00000330966.7	-	7	873	c.711C>G	c.(709-711)caC>caG	p.H237Q	MYOM3_ENST00000329601.7_Missense_Mutation_p.H236Q|MYOM3_ENST00000475306.1_5'UTR|MYOM3_ENST00000374434.3_Missense_Mutation_p.H236Q			Q5VTT5	MYOM3_HUMAN	myomesin 3	236	Ig-like C2-type 1.									NS(2)|breast(2)|central_nervous_system(1)|endometrium(5)|kidney(6)|large_intestine(3)|lung(40)|ovary(2)|prostate(1)|skin(4)|urinary_tract(2)	68		Colorectal(325;3.55e-05)|Renal(390;0.000703)|Lung NSC(340;0.001)|all_lung(284;0.0014)|Ovarian(437;0.00351)|Breast(348;0.0126)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;5.31e-24)|Colorectal(126;7.52e-08)|COAD - Colon adenocarcinoma(152;4.01e-06)|GBM - Glioblastoma multiforme(114;4.36e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00108)|KIRC - Kidney renal clear cell carcinoma(1967;0.00404)|STAD - Stomach adenocarcinoma(196;0.00966)|READ - Rectum adenocarcinoma(331;0.0678)|Lung(427;0.153)		AGGCCTGGCCGTGGGCGTTCT	0.592000													80	277					0	0	0.870114	0	0
RAB39B	116442	broad.mit.edu	37	X	154490293	154490293	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8096-01A-11D-2238-08	TCGA-55-8096-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	babd96af-bc23-49ee-b8ef-541bc076c7c4	fbc4dd00-fd9b-4988-aa44-ce1598a2150b	g.chrX:154490293C>A	ENST00000369454.3	-	2	737	c.437G>T	c.(436-438)gGc>gTc	p.G146V		NM_171998.2	NP_741995.1	Q96DA2	RB39B_HUMAN	RAB39B, member RAS oncogene family	146					protein transport|small GTPase mediated signal transduction|synapse organization|vesicle-mediated transport	Golgi apparatus|plasma membrane	GTP binding			breast(1)|central_nervous_system(2)|cervix(1)|kidney(1)|large_intestine(2)|lung(12)	19	all_cancers(53;1.86e-17)|all_epithelial(53;2.71e-11)|all_lung(58;1.84e-07)|Lung NSC(58;5.62e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)					GTACTTCATGCCGTATGCAGC	0.498000													6	59					0.0215528	0.0229607	0.217242	1	0
MAMLD1	10046	broad.mit.edu	37	X	149639428	149639428	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8096-01A-11D-2238-08	TCGA-55-8096-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	babd96af-bc23-49ee-b8ef-541bc076c7c4	fbc4dd00-fd9b-4988-aa44-ce1598a2150b	g.chrX:149639428G>T	ENST00000370401.2	+	4	1893	c.1583G>T	c.(1582-1584)aGc>aTc	p.S528I	MAMLD1_ENST00000426613.2_Missense_Mutation_p.S503I|MAMLD1_ENST00000455522.2_Missense_Mutation_p.S9I|MAMLD1_ENST00000262858.5_Missense_Mutation_p.S528I|MAMLD1_ENST00000432680.2_Missense_Mutation_p.S503I			Q13495	MAMD1_HUMAN	mastermind-like domain containing 1	528					male gonad development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				breast(1)|endometrium(4)|kidney(3)|large_intestine(12)|lung(14)|ovary(1)|prostate(2)	37	Acute lymphoblastic leukemia(192;6.56e-05)					GGGATGGCAAGCTCCAGCCCA	0.542000													25	86					9.86323e-18	1.49357e-17	0.667858	1	0
TESC	54997	broad.mit.edu	37	12	117476964	117476964	+	Missense_Mutation	SNP	T	T	C			TCGA-55-8096-01A-11D-2238-08	TCGA-55-8096-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	babd96af-bc23-49ee-b8ef-541bc076c7c4	fbc4dd00-fd9b-4988-aa44-ce1598a2150b	g.chr12:117476964T>C	ENST00000335209.7	-	8	805	c.619A>G	c.(619-621)Atg>Gtg	p.M207V	TESC_ENST00000541210.1_Missense_Mutation_p.M180V|TESC_ENST00000392545.4_Missense_Mutation_p.M260V			Q96BS2	TESC_HUMAN	tescalcin	207					negative regulation of cell proliferation|positive regulation of megakaryocyte differentiation|positive regulation of transcription, DNA-dependent|regulation of cell adhesion mediated by integrin	cytoplasm|lamellipodium|nucleus|plasma membrane|ruffle	calcium ion binding|magnesium ion binding|phosphatase inhibitor activity|protein binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(2)|upper_aerodigestive_tract(1)	6	all_neural(191;0.117)|Medulloblastoma(191;0.163)			BRCA - Breast invasive adenocarcinoma(302;0.0297)		ATGGTTTCCATGTTAAGGAAG	0.632000													4	52					0	0	0.184627	0	0
SHPRH	257218	broad.mit.edu	37	6	146266716	146266716	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8096-01A-11D-2238-08	TCGA-55-8096-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	babd96af-bc23-49ee-b8ef-541bc076c7c4	fbc4dd00-fd9b-4988-aa44-ce1598a2150b	g.chr6:146266716G>A	ENST00000367503.3	-	8	1777	c.1379C>T	c.(1378-1380)tCc>tTc	p.S460F	SHPRH_ENST00000438092.2_Missense_Mutation_p.S460F|SHPRH_ENST00000275233.7_Missense_Mutation_p.S460F|SHPRH_ENST00000367505.2_Missense_Mutation_p.S460F	NM_001042683.2	NP_001036148.2	Q149N8	SHPRH_HUMAN	SNF2 histone linker PHD RING helicase, E3 ubiquitin protein ligase	460	H15.		S -> F (in a melanoma cell line).		DNA repair|nucleosome assembly	nucleosome|nucleus	ATP binding|DNA binding|helicase activity|ligase activity|zinc ion binding			breast(2)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(15)|lung(33)|ovary(3)|pancreas(2)|prostate(7)|skin(1)|urinary_tract(1)	79		Ovarian(120;0.0365)		OV - Ovarian serous cystadenocarcinoma(155;1.47e-07)|GBM - Glioblastoma multiforme(68;0.0124)		GGAAAGGATGGACACTCCTTT	0.323000													5	28					0	0	0.217242	0	0
NLRP5	126206	broad.mit.edu	37	19	56561914	56561914	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8096-01A-11D-2238-08	TCGA-55-8096-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	babd96af-bc23-49ee-b8ef-541bc076c7c4	fbc4dd00-fd9b-4988-aa44-ce1598a2150b	g.chr19:56561914G>A	ENST00000390649.3	+	12	3088	c.3088G>A	c.(3088-3090)Gag>Aag	p.E1030K		NM_153447.4	NP_703148.4	P59047	NALP5_HUMAN	NLR family, pyrin domain containing 5	1030						mitochondrion|nucleolus	ATP binding			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|ovary(5)|skin(2)|stomach(4)|upper_aerodigestive_tract(2)	25		Colorectal(82;3.46e-05)|Ovarian(87;0.0481)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0326)		GCTTCTGTGCGAGGTCATGAG	0.517000													5	64					0	0	0.248553	0	0
CAPN10	11132	broad.mit.edu	37	2	241534098	241534098	+	Silent	SNP	G	G	A			TCGA-55-8096-01A-11D-2238-08	TCGA-55-8096-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	babd96af-bc23-49ee-b8ef-541bc076c7c4	fbc4dd00-fd9b-4988-aa44-ce1598a2150b	g.chr2:241534098G>A	ENST00000391984.2	+	6	1165	c.969G>A	c.(967-969)gaG>gaA	p.E323E	CAPN10_ENST00000404753.3_Silent_p.E323E|CAPN10_ENST00000352879.4_Intron|CAPN10_ENST00000391982.2_Silent_p.E323E|CAPN10_ENST00000270364.7_Intron|CAPN10_ENST00000354082.4_Silent_p.E323E	NM_023083.3	NP_075571.1	Q9HC96	CAN10_HUMAN	calpain 10	323	Domain III 1.				actin cytoskeleton reorganization|cellular response to insulin stimulus|positive regulation of apoptosis|positive regulation of glucose import|positive regulation of insulin secretion|positive regulation of intracellular transport|proteolysis	cytosol|plasma membrane	calcium-dependent cysteine-type endopeptidase activity|cytoskeletal protein binding|SNARE binding			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(11)|ovary(3)|urinary_tract(1)	27		all_epithelial(40;1.72e-15)|Breast(86;2.14e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0294)|all_neural(83;0.0459)|Lung NSC(271;0.094)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;1.13e-31)|all cancers(36;3.24e-29)|OV - Ovarian serous cystadenocarcinoma(60;2.82e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;5.1e-06)|Lung(119;0.00168)|Colorectal(34;0.00495)|LUSC - Lung squamous cell carcinoma(224;0.00813)|COAD - Colon adenocarcinoma(134;0.032)		CGGTCACGGAGGCCGGCCACC	0.662000													37	111					0	0	0.853193	0	0
SORT1	6272	broad.mit.edu	37	1	109897003	109897003	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8096-01A-11D-2238-08	TCGA-55-8096-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	babd96af-bc23-49ee-b8ef-541bc076c7c4	fbc4dd00-fd9b-4988-aa44-ce1598a2150b	g.chr1:109897003C>A	ENST00000256637.6	-	5	752	c.694G>T	c.(694-696)Gct>Tct	p.A232S	SORT1_ENST00000538502.1_Missense_Mutation_p.A96S	NM_002959.5	NP_002950.3	Q99523	SORT_HUMAN	sortilin 1	232					endocytosis|endosome to lysosome transport|endosome transport via multivesicular body sorting pathway|glucose import|Golgi to endosome transport|induction of apoptosis by extracellular signals|myotube differentiation|negative regulation of apoptosis|negative regulation of lipoprotein lipase activity|neuropeptide signaling pathway|ossification|plasma membrane to endosome transport|regulation of gene expression|response to insulin stimulus|vesicle organization	cell surface|coated pit|early endosome|endoplasmic reticulum membrane|endosome membrane|Golgi cisterna membrane|integral to membrane|lysosomal membrane|microsome|nuclear membrane|perinuclear region of cytoplasm|plasma membrane	enzyme binding|nerve growth factor binding|nerve growth factor receptor activity|neurotensin receptor activity, non-G-protein coupled			NS(1)|breast(2)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(9)|lung(5)|ovary(2)|prostate(1)|skin(1)	26		all_epithelial(167;4.69e-05)|all_lung(203;0.00016)|Lung NSC(277;0.000318)|Breast(1374;0.244)		Lung(183;0.0529)|Colorectal(144;0.142)|Epithelial(280;0.145)|Kidney(133;0.169)|all cancers(265;0.184)		GTGCTGAGAGCTAAAAGATAA	0.378000													7	85					0.00448238	0.00482368	0.307466	1	0
KCNH5	27133	broad.mit.edu	37	14	63417226	63417226	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8096-01A-11D-2238-08	TCGA-55-8096-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	babd96af-bc23-49ee-b8ef-541bc076c7c4	fbc4dd00-fd9b-4988-aa44-ce1598a2150b	g.chr14:63417226C>A	ENST00000322893.7	-	7	1262	c.994G>T	c.(994-996)Ggc>Tgc	p.G332C	KCNH5_ENST00000394964.2_Missense_Mutation_p.G274C|KCNH5_ENST00000394968.1_Missense_Mutation_p.G274C|KCNH5_ENST00000420622.2_Missense_Mutation_p.G332C	NM_139318.3	NP_647479.2	Q8NCM2	KCNH5_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 5	332					regulation of transcription, DNA-dependent	integral to membrane	calmodulin binding|two-component sensor activity|voltage-gated potassium channel activity			NS(1)|biliary_tract(1)|breast(3)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(22)|lung(33)|ovary(5)|prostate(2)|skin(17)|upper_aerodigestive_tract(4)|urinary_tract(2)	99				OV - Ovarian serous cystadenocarcinoma(108;0.00958)|BRCA - Breast invasive adenocarcinoma(234;0.168)		GCCACACGGCCCAGTCGTAAG	0.458000													5	62					0.0381472	0.0400357	0.278610	1	0
FAM127C	441518	broad.mit.edu	37	X	134156270	134156270	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8096-01A-11D-2238-08	TCGA-55-8096-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	babd96af-bc23-49ee-b8ef-541bc076c7c4	fbc4dd00-fd9b-4988-aa44-ce1598a2150b	g.chrX:134156270C>A	ENST00000391440.1	-	1	289	c.220G>T	c.(220-222)Ggg>Tgg	p.G74W		NM_001078173.1	NP_001071641.1	Q17RB0	F127C_HUMAN	family with sequence similarity 127, member C	74										breast(1)|endometrium(2)|large_intestine(1)|lung(2)	6	Acute lymphoblastic leukemia(192;0.000127)					AGGGCGGGCCCCGTGAGGCGG	0.602000													12	134					2.27111e-07	2.78309e-07	0.411799	1	0
CUX2	23316	broad.mit.edu	37	12	111786103	111786103	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8096-01A-11D-2238-08	TCGA-55-8096-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	babd96af-bc23-49ee-b8ef-541bc076c7c4	fbc4dd00-fd9b-4988-aa44-ce1598a2150b	g.chr12:111786103G>A	ENST00000261726.6	+	22	4589	c.4435G>A	c.(4435-4437)Gag>Aag	p.E1479K		NM_015267.3	NP_056082.2	O14529	CUX2_HUMAN	cut-like homeobox 2	1479						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(2)|large_intestine(9)|lung(24)|ovary(5)|prostate(4)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	55						TGCCAATCGGGAGGAGGCCCT	0.572000													21	170					0	0	0.608945	0	0
MYO9A	4649	broad.mit.edu	37	15	72338223	72338223	+	Nonsense_Mutation	SNP	G	G	A			TCGA-55-8096-01A-11D-2238-08	TCGA-55-8096-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	babd96af-bc23-49ee-b8ef-541bc076c7c4	fbc4dd00-fd9b-4988-aa44-ce1598a2150b	g.chr15:72338223G>A	ENST00000356056.5	-	2	1154	c.682C>T	c.(682-684)Cag>Tag	p.Q228*	MYO9A_ENST00000563542.1_5'UTR|MYO9A_ENST00000566885.1_Intron|MYO9A_ENST00000564571.1_Nonsense_Mutation_p.Q228*|MYO9A_ENST00000424560.1_Nonsense_Mutation_p.Q228*|MYO9A_ENST00000444904.1_Nonsense_Mutation_p.Q228*	NM_006901.3	NP_008832.2	B2RTY4	MYO9A_HUMAN	myosin IXA	228	Myosin head-like 1.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction|visual perception	cytosol|integral to membrane|unconventional myosin complex	actin binding|ATP binding|GTPase activator activity|metal ion binding|motor activity			NS(4)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(29)|lung(27)|ovary(1)|pancreas(1)|prostate(5)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	88						TTTTTGCGCTGAAGCATGGCA	0.423000													6	47					0	0	0.217242	0	0
LOC101927209	101927209	broad.mit.edu	37	1	142713773	142713773	+	RNA	SNP	C	C	G			TCGA-55-8096-01A-11D-2238-08	TCGA-55-8096-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	babd96af-bc23-49ee-b8ef-541bc076c7c4	fbc4dd00-fd9b-4988-aa44-ce1598a2150b	g.chr1:142713773C>G	ENST00000369381.2	-	0	832																											TCTTTTTCCACATTGTCATTT	0.284000													3	62					0	0	0.115264	0	0
MUC16	94025	broad.mit.edu	37	19	9091606	9091606	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8096-01A-11D-2238-08	TCGA-55-8096-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	babd96af-bc23-49ee-b8ef-541bc076c7c4	fbc4dd00-fd9b-4988-aa44-ce1598a2150b	g.chr19:9091606G>A	ENST00000397910.4	-	1	412	c.209C>T	c.(208-210)tCg>tTg	p.S70L		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	70	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TCCCACAACCGAAGATGTAGG	0.522000													13	78					0	0	0.457914	0	0
GZMA	3001	broad.mit.edu	37	5	54401380	54401380	+	Missense_Mutation	SNP	G	G	C			TCGA-55-8096-01A-11D-2238-08	TCGA-55-8096-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	babd96af-bc23-49ee-b8ef-541bc076c7c4	fbc4dd00-fd9b-4988-aa44-ce1598a2150b	g.chr5:54401380G>C	ENST00000274306.6	+	2	184	c.149G>C	c.(148-150)aGa>aCa	p.R50T		NM_006144.3	NP_006135.1	P12544	GRAA_HUMAN	granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)	50	Peptidase S1.			DRKT -> KPDS (in Ref. 5; no nucleotide entry).	cleavage of lamin|cytolysis|immune response|negative regulation of DNA binding|negative regulation of endodeoxyribonuclease activity|negative regulation of oxidoreductase activity|positive regulation of apoptosis	extracellular region|immunological synapse|nucleus	protein homodimerization activity|serine-type endopeptidase activity			NS(1)|breast(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(9)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	25		Lung NSC(810;4.08e-05)|Breast(144;0.0433)|Prostate(74;0.183)				AGTCTTGACAGAAAAACCATC	0.383000													4	92					0	0	0.184627	0	0
ZFHX4	79776	broad.mit.edu	37	8	77766703	77766703	+	Missense_Mutation	SNP	T	T	A			TCGA-55-8096-01A-11D-2238-08	TCGA-55-8096-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	babd96af-bc23-49ee-b8ef-541bc076c7c4	fbc4dd00-fd9b-4988-aa44-ce1598a2150b	g.chr8:77766703T>A	ENST00000521891.2	+	10	7994	c.7546T>A	c.(7546-7548)Ttc>Atc	p.F2516I	ZFHX4_ENST00000518282.1_Missense_Mutation_p.F2490I|ZFHX4_ENST00000455469.2_Missense_Mutation_p.F2471I|ZFHX4_ENST00000050961.6_Missense_Mutation_p.F2471I	NM_024721.4	NP_078997.4	Q86UP3	ZFHX4_HUMAN	zinc finger homeobox 4	2471						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(3)|breast(11)|central_nervous_system(1)|endometrium(36)|haematopoietic_and_lymphoid_tissue(2)|kidney(15)|large_intestine(66)|liver(2)|lung(245)|ovary(11)|pancreas(3)|prostate(11)|skin(7)|upper_aerodigestive_tract(13)|urinary_tract(6)	432			BRCA - Breast invasive adenocarcinoma(89;0.0895)			GCACATGCACTTCCTTGCTGC	0.488000										HNSCC(33;0.089)			18	193					0	0	0.624587	0	0
ADAMTS5	11096	broad.mit.edu	37	21	28302244	28302244	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8096-01A-11D-2238-08	TCGA-55-8096-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	babd96af-bc23-49ee-b8ef-541bc076c7c4	fbc4dd00-fd9b-4988-aa44-ce1598a2150b	g.chr21:28302244G>T	ENST00000284987.5	-	7	2307	c.2186C>A	c.(2185-2187)tCc>tAc	p.S729Y	AP001601.2_ENST00000426771.1_RNA	NM_007038.3	NP_008969.2	Q9UNA0	ATS5_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 5	729	Cys-rich.				proteolysis	proteinaceous extracellular matrix	integrin binding|metalloendopeptidase activity|zinc ion binding			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(17)|lung(34)|ovary(3)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)	72						TGTACAGCTGGAGTTGTCTCC	0.438000													43	132					1.76056e-25	2.89332e-25	0.859065	1	0
HIP1	3092	broad.mit.edu	37	7	75187519	75187519	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8096-01A-11D-2238-08	TCGA-55-8096-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	babd96af-bc23-49ee-b8ef-541bc076c7c4	fbc4dd00-fd9b-4988-aa44-ce1598a2150b	g.chr7:75187519C>A	ENST00000336926.6	-	15	1442	c.1416G>T	c.(1414-1416)aaG>aaT	p.K472N	HIP1_ENST00000434438.2_Missense_Mutation_p.K472N	NM_005338.5	NP_005329.3	O00291	HIP1_HUMAN	huntingtin interacting protein 1	472	pDED.				activation of caspase activity|cell differentiation|clathrin coat assembly|endocytosis|induction of apoptosis|positive regulation of receptor-mediated endocytosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	clathrin coated vesicle membrane|cytoskeleton|Golgi apparatus|membrane fraction|nucleus	actin binding|clathrin binding|phosphatidylinositol binding|structural constituent of cytoskeleton			breast(3)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(25)|ovary(2)|pancreas(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	51						TGTACTTCTCCTTTAGCTTGC	0.547000			T	PDGFRB	CMML								7	97					0.000274275	0.000312615	0.307466	1	0
SFI1	9814	broad.mit.edu	37	22	32009156	32009156	+	Missense_Mutation	SNP	C	C	T			TCGA-55-8096-01A-11D-2238-08	TCGA-55-8096-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	babd96af-bc23-49ee-b8ef-541bc076c7c4	fbc4dd00-fd9b-4988-aa44-ce1598a2150b	g.chr22:32009156C>T	ENST00000432498.1	+	24	2819	c.2426C>T	c.(2425-2427)gCg>gTg	p.A809V	SFI1_ENST00000540643.1_Missense_Mutation_p.A785V|SFI1_ENST00000414585.1_Missense_Mutation_p.A687V|SFI1_ENST00000443326.1_Missense_Mutation_p.A758V|SFI1_ENST00000400289.1_Missense_Mutation_p.A758V|SFI1_ENST00000443011.1_Missense_Mutation_p.A687V|SFI1_ENST00000400288.2_Missense_Mutation_p.A840V	NM_014775.3	NP_055590.2	A8K8P3	SFI1_HUMAN	Sfi1 homolog, spindle assembly associated (yeast)	840					G2/M transition of mitotic cell cycle	centriole|cytosol				NS(2)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(5)|large_intestine(7)|liver(1)|lung(11)|ovary(1)|prostate(3)|upper_aerodigestive_tract(3)	38						GAGCAGCGGGCGACAGTGCGG	0.632000													13	37					0	0	0.520397	0	0
MYL2	4633	broad.mit.edu	37	12	111353531	111353531	+	Missense_Mutation	SNP	A	A	C			TCGA-55-8096-01A-11D-2238-08	TCGA-55-8096-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	babd96af-bc23-49ee-b8ef-541bc076c7c4	fbc4dd00-fd9b-4988-aa44-ce1598a2150b	g.chr12:111353531A>C	ENST00000228841.8	-	3	204	c.157T>G	c.(157-159)Ttt>Gtt	p.F53V	MYL2_ENST00000548438.1_Intron	NM_000432.3	NP_000423.2	P10916	MLRV_HUMAN	myosin, light chain 2, regulatory, cardiac, slow	53	EF-hand 1.				cardiac myofibril assembly|heart contraction|muscle filament sliding|negative regulation of cell growth|regulation of striated muscle contraction|ventricular cardiac muscle tissue morphogenesis	cytosol|myosin complex|sarcomere	actin monomer binding|calcium ion binding|myosin heavy chain binding|structural constituent of muscle			endometrium(2)|kidney(1)|large_intestine(2)|lung(4)|ovary(2)|prostate(1)	12						AGGGCAGCAAAGGTGTCTCTC	0.522000													22	184					0	0	0.654019	0	0
ABCG4	64137	broad.mit.edu	37	11	119029411	119029411	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8096-01A-11D-2238-08	TCGA-55-8096-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	babd96af-bc23-49ee-b8ef-541bc076c7c4	fbc4dd00-fd9b-4988-aa44-ce1598a2150b	g.chr11:119029411G>A	ENST00000307417.3	+	11	1676	c.1312G>A	c.(1312-1314)Gcc>Acc	p.A438T	ABCG4_ENST00000449422.2_Missense_Mutation_p.A438T|ABCG4_ENST00000531739.1_Missense_Mutation_p.A438T	NM_022169.4	NP_071452.2	Q9H172	ABCG4_HUMAN	ATP-binding cassette, sub-family G (WHITE), member 4	438	ABC transmembrane type-2.				cholesterol efflux	integral to membrane	ATP binding|ATPase activity|protein heterodimerization activity|protein homodimerization activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(28)|ovary(2)|prostate(1)|skin(1)	44	all_hematologic(175;0.0977)	Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.7e-05)		CATGTTCGCCGCCCTCATGCC	0.632000													6	120					0	0	0.217242	0	0
LRRIQ1	84125	broad.mit.edu	37	12	85623306	85623306	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8096-01A-11D-2238-08	TCGA-55-8096-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	babd96af-bc23-49ee-b8ef-541bc076c7c4	fbc4dd00-fd9b-4988-aa44-ce1598a2150b	g.chr12:85623306G>A	ENST00000393217.2	+	25	4895	c.4834G>A	c.(4834-4836)Gac>Aac	p.D1612N	LRRIQ1_ENST00000528777.3_3'UTR	NM_001079910.1	NP_001073379.1	Q96JM4	LRIQ1_HUMAN	leucine-rich repeats and IQ motif containing 1	1612										breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(21)|liver(1)|lung(28)|ovary(5)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)	83				GBM - Glioblastoma multiforme(134;0.212)		TATAGAAGAAGACCCTATCCA	0.373000													6	87					0	0	0.278610	0	0
CEP78	84131	broad.mit.edu	37	9	80851322	80851322	+	Missense_Mutation	SNP	A	A	T			TCGA-55-8096-01A-11D-2238-08	TCGA-55-8096-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	babd96af-bc23-49ee-b8ef-541bc076c7c4	fbc4dd00-fd9b-4988-aa44-ce1598a2150b	g.chr9:80851322A>T	ENST00000424347.2	+	1	345	c.56A>T	c.(55-57)tAc>tTc	p.Y19F	CEP78_ENST00000277082.5_Missense_Mutation_p.Y19F|CEP78_ENST00000415759.2_Missense_Mutation_p.Y19F|CEP78_ENST00000376597.4_Missense_Mutation_p.Y19F|CEP78_ENST00000376598.2_Missense_Mutation_p.Y19F			Q5JTW2	CEP78_HUMAN	centrosomal protein 78kDa	19					G2/M transition of mitotic cell cycle	centrosome|cytosol				breast(1)|cervix(1)|endometrium(5)|large_intestine(7)|lung(4)|ovary(1)|stomach(1)|urinary_tract(1)	21						TTCTCCCACTACGAGTACCTG	0.731000													9	14					0	0	0.307466	0	0
OR5M8	219484	broad.mit.edu	37	11	56258451	56258451	+	Silent	SNP	G	G	T			TCGA-55-8096-01A-11D-2238-08	TCGA-55-8096-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	babd96af-bc23-49ee-b8ef-541bc076c7c4	fbc4dd00-fd9b-4988-aa44-ce1598a2150b	g.chr11:56258451G>T	ENST00000327216.2	-	1	420	c.396C>A	c.(394-396)ggC>ggA	p.G132G		NM_001005282.1	NP_001005282.1	Q8NGP6	OR5M8_HUMAN	olfactory receptor, family 5, subfamily M, member 8	132					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(4)|lung(22)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	37	Esophageal squamous(21;0.00352)					ACATTCTGCTGCCATAAAGCA	0.512000													5	74					0.00198382	0.00215677	0.248553	1	0
MBTPS1	8720	broad.mit.edu	37	16	84089675	84089675	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8096-01A-11D-2238-08	TCGA-55-8096-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	babd96af-bc23-49ee-b8ef-541bc076c7c4	fbc4dd00-fd9b-4988-aa44-ce1598a2150b	g.chr16:84089675C>A	ENST00000343411.3	-	22	3392	c.2897G>T	c.(2896-2898)cGa>cTa	p.R966L		NM_003791.2	NP_003782.1	Q14703	MBTP1_HUMAN	membrane-bound transcription factor peptidase, site 1	966					cholesterol metabolic process|proteolysis	endoplasmic reticulum lumen|endoplasmic reticulum membrane|Golgi membrane|integral to membrane	serine-type endopeptidase activity			NS(1)|breast(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(12)|lung(10)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	41						GCGATTCGATCGAAAGTTGGG	0.483000													19	74					8.34094e-07	1.01625e-06	0.575678	1	0
ILF2	3608	broad.mit.edu	37	1	153641006	153641006	+	Missense_Mutation	SNP	G	G	C			TCGA-55-8096-01A-11D-2238-08	TCGA-55-8096-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	babd96af-bc23-49ee-b8ef-541bc076c7c4	fbc4dd00-fd9b-4988-aa44-ce1598a2150b	g.chr1:153641006G>C	ENST00000361891.4	-	4	261	c.136C>G	c.(136-138)Cca>Gca	p.P46A	ILF2_ENST00000368681.1_Missense_Mutation_p.P46A	NM_001267809.1|NM_004515.3	NP_001254738.1|NP_004506.2	Q12905	ILF2_HUMAN	interleukin enhancer binding factor 2	46					immune response|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus|ribonucleoprotein complex	ATP binding|DNA binding|double-stranded RNA binding|protein binding|transferase activity			cervix(1)|kidney(1)|lung(4)|skin(1)	7	all_lung(78;1.84e-32)|Lung NSC(65;6.67e-31)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.171)			TCAGGTGCTGGCTTGACCCGG	0.438000													5	68					0	0	0.278610	0	0
PRDM14	63978	broad.mit.edu	37	8	70978618	70978618	+	Silent	SNP	T	T	C			TCGA-55-8096-01A-11D-2238-08	TCGA-55-8096-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	babd96af-bc23-49ee-b8ef-541bc076c7c4	fbc4dd00-fd9b-4988-aa44-ce1598a2150b	g.chr8:70978618T>C	ENST00000276594.2	-	5	1236	c.1035A>G	c.(1033-1035)caA>caG	p.Q345Q		NM_024504.3	NP_078780.1	Q9GZV8	PRD14_HUMAN	PR domain containing 14	345	SET.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|endometrium(4)|kidney(4)|large_intestine(3)|lung(13)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	32	Breast(64;0.193)		Epithelial(68;0.00508)|all cancers(69;0.0259)|OV - Ovarian serous cystadenocarcinoma(28;0.0405)			ATATATGCCCTTGACACTGCA	0.468000													16	85					0	0	0.520397	0	0
DCAF4L2	138009	broad.mit.edu	37	8	88885956	88885956	+	Missense_Mutation	SNP	T	T	A			TCGA-55-8096-01A-11D-2238-08	TCGA-55-8096-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	babd96af-bc23-49ee-b8ef-541bc076c7c4	fbc4dd00-fd9b-4988-aa44-ce1598a2150b	g.chr8:88885956T>A	ENST00000319675.3	-	1	340	c.244A>T	c.(244-246)Aac>Tac	p.N82Y		NM_152418.3	NP_689631.1	Q8NA75	DC4L2_HUMAN	DDB1 and CUL4 associated factor 4-like 2	82										breast(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(19)|liver(2)|lung(40)|ovary(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	83						TGGTCAGTGTTGGTATTCGCC	0.542000													14	127					0	0	0.520397	0	0
TP53	7157	broad.mit.edu	37	17	7574012	7574012	+	Nonsense_Mutation	SNP	C	C	A	rs17882252		TCGA-55-8096-01A-11D-2238-08	TCGA-55-8096-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	babd96af-bc23-49ee-b8ef-541bc076c7c4	fbc4dd00-fd9b-4988-aa44-ce1598a2150b	g.chr17:7574012C>A	ENST00000269305.4	-	10	1204	c.1015G>T	c.(1015-1017)Gag>Tag	p.E339*	TP53_ENST00000445888.2_Nonsense_Mutation_p.E339*|TP53_ENST00000413465.2_Intron|TP53_ENST00000359597.4_Intron|TP53_ENST00000455263.2_3'UTR|TP53_ENST00000420246.2_3'UTR	NM_000546.5|NM_001126112.2|NM_001126118.1|NM_001276760.1|NM_001276761.1	NP_000537.3|NP_001119584.1|NP_001119590.1|NP_001263689.1|NP_001263690.1	P04637	P53_HUMAN	tumor protein p53	339	Interaction with CARM1.|Interaction with HIPK1 (By similarity).|Interaction with HIPK2.|Oligomerization.		E -> K (in a sporadic cancer; somatic mutation; dbSNP:rs17882252).|E -> Q (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.E339*(14)|p.0?(8)|p.E339fs*8(2)|p.E339Q(1)|p.?(1)|p.F338fs*6(1)|p.F338_E339>L(1)|p.E339fs*13(1)|p.I332fs*5(1)|p.E339K(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CGGAACATCTCGAAGCGCTCA	0.537000		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			9	35					0.00136819	0.00151071	0.411799	1	0
FRAS1	80144	broad.mit.edu	37	4	79340120	79340120	+	Silent	SNP	G	G	T			TCGA-55-8096-01A-11D-2238-08	TCGA-55-8096-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	babd96af-bc23-49ee-b8ef-541bc076c7c4	fbc4dd00-fd9b-4988-aa44-ce1598a2150b	g.chr4:79340120G>T	ENST00000264895.6	+	33	4883	c.4443G>T	c.(4441-4443)ctG>ctT	p.L1481L	FRAS1_ENST00000325942.6_Silent_p.L1481L	NM_025074.6	NP_079350.5	Q86XX4	FRAS1_HUMAN	Fraser syndrome 1	1480					cell communication	integral to membrane|plasma membrane	metal ion binding			breast(2)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(5)|lung(54)|prostate(7)|skin(2)|urinary_tract(4)	103						AAGATGGCCTGACTGTTATTC	0.393000													25	86					3.80469e-20	6.06463e-20	0.740014	1	0
DST	667	broad.mit.edu	37	6	56374667	56374667	+	Missense_Mutation	SNP	T	T	A			TCGA-55-8096-01A-11D-2238-08	TCGA-55-8096-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	babd96af-bc23-49ee-b8ef-541bc076c7c4	fbc4dd00-fd9b-4988-aa44-ce1598a2150b	g.chr6:56374667T>A	ENST00000370754.5	-	74	18691	c.18692A>T	c.(18691-18693)cAt>cTt	p.H6231L	DST_ENST00000361203.3_Missense_Mutation_p.H5942L|DST_ENST00000446842.2_Missense_Mutation_p.H5727L|DST_ENST00000312431.6_3'UTR|DST_ENST00000370788.2_Missense_Mutation_p.H3856L|DST_ENST00000370769.4_Missense_Mutation_p.H6053L|DST_ENST00000340834.4_5'UTR|DST_ENST00000421834.2_Missense_Mutation_p.H3965L|DST_ENST00000244364.6_Missense_Mutation_p.H3639L			Q03001	DYST_HUMAN	dystonin	6051					cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			NS(1)|breast(5)|central_nervous_system(8)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(22)|lung(43)|ovary(7)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)	105	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			TATCTTGTCATGGAACTAGGG	0.393000													9	29					0	0	0.335167	0	0
COL24A1	255631	broad.mit.edu	37	1	86342844	86342844	+	Silent	SNP	C	C	A			TCGA-55-8096-01A-11D-2238-08	TCGA-55-8096-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	babd96af-bc23-49ee-b8ef-541bc076c7c4	fbc4dd00-fd9b-4988-aa44-ce1598a2150b	g.chr1:86342844C>A	ENST00000370571.2	-	33	3357	c.2991G>T	c.(2989-2991)ctG>ctT	p.L997L	COL24A1_ENST00000436319.1_Silent_p.L997L	NM_152890.5	NP_690850.2	Q17RW2	COOA1_HUMAN	collagen, type XXIV, alpha 1	997	Collagen-like 8.				cell adhesion	collagen	extracellular matrix structural constituent			NS(3)|central_nervous_system(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(9)|liver(1)|lung(56)|ovary(4)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	101				all cancers(265;0.0627)|Epithelial(280;0.0689)		CATCACCTTGCAGTCCTCGCA	0.328000													11	44					9.05144e-12	1.2145e-11	0.435327	1	0
PLXNA1	5361	broad.mit.edu	37	3	126741074	126741074	+	Silent	SNP	G	G	T			TCGA-55-8096-01A-11D-2238-08	TCGA-55-8096-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	babd96af-bc23-49ee-b8ef-541bc076c7c4	fbc4dd00-fd9b-4988-aa44-ce1598a2150b	g.chr3:126741074G>T	ENST00000393409.2	+	21	4185	c.4185G>T	c.(4183-4185)acG>acT	p.T1395T	PLXNA1_ENST00000251772.4_Silent_p.T1372T	NM_032242.3	NP_115618.3	Q9UIW2	PLXA1_HUMAN	plexin A1	1395					axon guidance	integral to membrane|intracellular|plasma membrane	semaphorin receptor activity			breast(3)|central_nervous_system(5)|endometrium(10)|kidney(5)|large_intestine(4)|lung(32)|ovary(2)|pancreas(1)|prostate(2)|skin(3)	67				GBM - Glioblastoma multiforme(114;0.155)		TCATCATGACGGCCCTGCAGG	0.607000													7	51					1.76689e-08	2.21646e-08	0.335167	1	0
AMER1	139285	broad.mit.edu	37	X	63412796	63412796	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8096-01A-11D-2238-08	TCGA-55-8096-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	babd96af-bc23-49ee-b8ef-541bc076c7c4	fbc4dd00-fd9b-4988-aa44-ce1598a2150b	g.chrX:63412796G>A	ENST00000330258.3	-	2	643	c.371C>T	c.(370-372)cCc>cTc	p.P124L	AMER1_ENST00000403336.1_Missense_Mutation_p.P124L|AMER1_ENST00000374869.3_Missense_Mutation_p.P124L	NM_152424.3	NP_689637.3			APC membrane recruitment protein 1									p.0?(67)									AAATTGGCAGGGTAACTCAGG	0.557000													7	76					0	0	0.278610	0	0
NOMO1	23420	broad.mit.edu	37	16	14982982	14982982	+	Silent	SNP	C	C	A			TCGA-55-8096-01A-11D-2238-08	TCGA-55-8096-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	babd96af-bc23-49ee-b8ef-541bc076c7c4	fbc4dd00-fd9b-4988-aa44-ce1598a2150b	g.chr16:14982982C>A	ENST00000287667.7	+	29	3525	c.3354C>A	c.(3352-3354)ctC>ctA	p.L1118L		NM_014287.3	NP_055102.3	Q15155	NOMO1_HUMAN	NODAL modulator 1	1118						integral to membrane	carbohydrate binding|carboxypeptidase activity|protein binding			endometrium(6)|kidney(1)|large_intestine(6)|lung(12)|ovary(2)|pancreas(1)|skin(2)	30						ACTCCACACTCCCCAGATCCC	0.418000													40	451					9.59835e-30	1.58973e-29	0.870114	1	0
TMEM185A	84548	broad.mit.edu	37	X	148690455	148690455	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8096-01A-11D-2238-08	TCGA-55-8096-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	babd96af-bc23-49ee-b8ef-541bc076c7c4	fbc4dd00-fd9b-4988-aa44-ce1598a2150b	g.chrX:148690455C>A	ENST00000316916.8	-	3	586	c.282G>T	c.(280-282)ttG>ttT	p.L94F	TMEM185A_ENST00000507237.1_Missense_Mutation_p.L94F|TMEM185A_ENST00000536359.1_Missense_Mutation_p.L35F	NM_032508.2	NP_115897.1	Q8NFB2	T185A_HUMAN	transmembrane protein 185A	94						integral to membrane				kidney(1)|large_intestine(3)|lung(10)|ovary(1)	15	Acute lymphoblastic leukemia(192;6.56e-05)|Colorectal(9;0.0662)					CAAACATCAACAAGAGCAAGT	0.473000													52	162					5.82388e-19	9.14565e-19	0.870114	1	0
PTPRB	5787	broad.mit.edu	37	12	70956767	70956767	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8096-01A-11D-2238-08	TCGA-55-8096-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	babd96af-bc23-49ee-b8ef-541bc076c7c4	fbc4dd00-fd9b-4988-aa44-ce1598a2150b	g.chr12:70956767C>A	ENST00000334414.6	-	16	4069	c.4025G>T	c.(4024-4026)gGg>gTg	p.G1342V	PTPRB_ENST00000451516.2_Missense_Mutation_p.G1034V|PTPRB_ENST00000550358.1_Missense_Mutation_p.G1254V|PTPRB_ENST00000261266.5_Missense_Mutation_p.G1124V|PTPRB_ENST00000538708.1_Missense_Mutation_p.G1034V|PTPRB_ENST00000551525.1_Missense_Mutation_p.G1341V|PTPRB_ENST00000550857.1_Missense_Mutation_p.G1034V	NM_001109754.2	NP_001103224.1	P23467	PTPRB_HUMAN	protein tyrosine phosphatase, receptor type, B	1124	Fibronectin type-III 15.				angiogenesis	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			breast(4)|central_nervous_system(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(8)|lung(46)|prostate(4)|skin(18)|upper_aerodigestive_tract(1)|urinary_tract(3)	107	Renal(347;0.236)		GBM - Glioblastoma multiforme(2;2.17e-05)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00306)|STAD - Stomach adenocarcinoma(21;0.149)			CTGGAGATTCCCATCTGGGTT	0.512000													7	60					0.000157383	0.000181333	0.278610	1	0
TNN	63923	broad.mit.edu	37	1	175097242	175097242	+	Silent	SNP	C	C	T			TCGA-55-8096-01A-11D-2238-08	TCGA-55-8096-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	babd96af-bc23-49ee-b8ef-541bc076c7c4	fbc4dd00-fd9b-4988-aa44-ce1598a2150b	g.chr1:175097242C>T	ENST00000239462.4	+	14	3233	c.3120C>T	c.(3118-3120)tcC>tcT	p.S1040S		NM_022093.1	NP_071376.1	Q9UQP3	TENN_HUMAN	tenascin N	1040	Fibronectin type-III 9.				cell growth|cell migration|signal transduction	extracellular space|proteinaceous extracellular matrix				NS(1)|central_nervous_system(2)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(29)|liver(1)|lung(81)|ovary(5)|prostate(6)|skin(5)|stomach(4)|upper_aerodigestive_tract(3)|urinary_tract(3)	156		Breast(1374;0.000962)		KIRC - Kidney renal clear cell carcinoma(1967;0.00198)		ACCCTGTCTCCCTTGTTGCCT	0.532000													10	91					0	0	0.411799	0	0
TSPAN14	81619	broad.mit.edu	37	10	82277664	82277664	+	Missense_Mutation	SNP	T	T	C			TCGA-55-8096-01A-11D-2238-08	TCGA-55-8096-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	babd96af-bc23-49ee-b8ef-541bc076c7c4	fbc4dd00-fd9b-4988-aa44-ce1598a2150b	g.chr10:82277664T>C	ENST00000429989.2	+	9	968	c.745T>C	c.(745-747)Ttt>Ctt	p.F249L	TSPAN14_ENST00000372158.1_Missense_Mutation_p.F249L|TSPAN14_ENST00000481124.1_Missense_Mutation_p.F126L|TSPAN14_ENST00000265450.5_3'UTR|TSPAN14_ENST00000372156.1_Missense_Mutation_p.F249L|TSPAN14_ENST00000341863.6_Missense_Mutation_p.F192L|TSPAN14_ENST00000372164.3_Missense_Mutation_p.F232L	NM_030927.2	NP_112189.2	Q8NG11	TSN14_HUMAN	tetraspanin 14	249						integral to membrane				central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(1)|ovary(1)|skin(1)	7			Colorectal(32;0.229)			GTTTCAGATATTTGGCATCTT	0.612000													2	5					0	0	0.115264	0	0
NPAP1	23742	broad.mit.edu	37	15	24921732	24921732	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8096-01A-11D-2238-08	TCGA-55-8096-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	babd96af-bc23-49ee-b8ef-541bc076c7c4	fbc4dd00-fd9b-4988-aa44-ce1598a2150b	g.chr15:24921732C>A	ENST00000329468.2	+	1	1192	c.718C>A	c.(718-720)Ccc>Acc	p.P240T		NM_018958.2	NP_061831.2			nuclear pore associated protein 1																		CCCTGCCATGCCCAGCACACA	0.617000													27	62					3.90053e-15	5.70284e-15	0.760397	1	0
AFF2	2334	broad.mit.edu	37	X	147985783	147985783	+	Silent	SNP	T	T	A			TCGA-55-8096-01A-11D-2238-08	TCGA-55-8096-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	babd96af-bc23-49ee-b8ef-541bc076c7c4	fbc4dd00-fd9b-4988-aa44-ce1598a2150b	g.chrX:147985783T>A	ENST00000370460.2	+	9	1871	c.1392T>A	c.(1390-1392)ccT>ccA	p.P464P	AFF2_ENST00000342251.3_Silent_p.P431P|AFF2_ENST00000370457.5_Silent_p.P431P|AFF2_ENST00000370458.1_Silent_p.P425P|AFF2_ENST00000286437.5_Silent_p.P105P	NM_001169123.1|NM_002025.3	NP_001162594.1|NP_002016.2	P51816	AFF2_HUMAN	AF4/FMR2 family, member 2	464					brain development|mRNA processing|regulation of RNA splicing|RNA splicing	nuclear speck	G-quadruplex RNA binding|protein binding			breast(5)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(29)|liver(2)|lung(39)|ovary(4)|pancreas(5)|prostate(1)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	109	Acute lymphoblastic leukemia(192;6.56e-05)					GGAATAATCCTGTGAAGTAAG	0.318000													12	148					0	0	0.387290	0	0
MSH6	2956	broad.mit.edu	37	2	48025765	48025765	+	Missense_Mutation	SNP	G	G	A	rs145959653		TCGA-55-8096-01A-11D-2238-08	TCGA-55-8096-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	babd96af-bc23-49ee-b8ef-541bc076c7c4	fbc4dd00-fd9b-4988-aa44-ce1598a2150b	g.chr2:48025765G>A	ENST00000234420.4	+	4	795	c.643G>A	c.(643-645)Gta>Ata	p.V215I	FBXO11_ENST00000405808.1_Intron|MSH6_ENST00000538136.1_5'UTR|MSH6_ENST00000540021.1_Missense_Mutation_p.V85I	NM_000179.2	NP_000170.1	P52701	MSH6_HUMAN	mutS homolog 6	215					determination of adult lifespan|DNA damage response, signal transduction resulting in induction of apoptosis|isotype switching|meiotic mismatch repair|negative regulation of DNA recombination|positive regulation of helicase activity|reciprocal meiotic recombination|response to UV|somatic hypermutation of immunoglobulin genes	MutSalpha complex	ATP binding|DNA-dependent ATPase activity|protein binding	p.0?(2)		breast(8)|central_nervous_system(29)|cervix(1)|endometrium(32)|haematopoietic_and_lymphoid_tissue(12)|kidney(2)|large_intestine(75)|lung(25)|ovary(3)|prostate(3)|skin(10)|stomach(22)|thyroid(1)|upper_aerodigestive_tract(1)|urinary_tract(5)	229		Acute lymphoblastic leukemia(82;0.0299)|all_hematologic(82;0.0358)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)			CACAACTTACGTAACAGATAA	0.363000			"""Mis, N, F, S"""		colorectal	"""colorectal, endometrial, ovarian"""		Mismatch excision repair (MMR)	Turcot syndrome;Muir-Torre syndrome;Lynch syndrome;Constitutional Mismatch Repair Deficiency Syndrome				5	71					0	0	0.184627	0	0
COQ9	57017	broad.mit.edu	37	16	57490459	57490459	+	Missense_Mutation	SNP	A	A	G			TCGA-55-8096-01A-11D-2238-08	TCGA-55-8096-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	babd96af-bc23-49ee-b8ef-541bc076c7c4	fbc4dd00-fd9b-4988-aa44-ce1598a2150b	g.chr16:57490459A>G	ENST00000262507.6	+	4	491	c.422A>G	c.(421-423)gAt>gGt	p.D141G	COQ9_ENST00000567933.1_Intron|COQ9_ENST00000567072.1_Missense_Mutation_p.D141G	NM_020312.3	NP_064708.1	O75208	COQ9_HUMAN	coenzyme Q9	141					ubiquinone biosynthetic process	mitochondrion				breast(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(3)|lung(6)|prostate(1)	16						TTCGGGAAGGATGGCAGTGAG	0.532000													29	81					0	0	0.779181	0	0
ZNF709	163051	broad.mit.edu	37	19	12575498	12575498	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8096-01A-11D-2238-08	TCGA-55-8096-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	babd96af-bc23-49ee-b8ef-541bc076c7c4	fbc4dd00-fd9b-4988-aa44-ce1598a2150b	g.chr19:12575498G>A	ENST00000397732.3	-	4	1409	c.1238C>T	c.(1237-1239)aCt>aTt	p.T413I	CTD-3105H18.18_ENST00000598753.1_Intron|ZNF709_ENST00000428311.1_Missense_Mutation_p.T413I	NM_152601.3	NP_689814.1	Q8N972	ZN709_HUMAN	zinc finger protein 709	413					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.T413I(2)		large_intestine(3)|upper_aerodigestive_tract(3)	6						TCCAGTGTGAGTTCTTTCATG	0.418000													5	127					0	0	0.184627	0	0
OR4K5	79317	broad.mit.edu	37	14	20389313	20389313	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8096-01A-11D-2238-08	TCGA-55-8096-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	babd96af-bc23-49ee-b8ef-541bc076c7c4	fbc4dd00-fd9b-4988-aa44-ce1598a2150b	g.chr14:20389313G>T	ENST00000315915.4	+	1	573	c.548G>T	c.(547-549)cGa>cTa	p.R183L		NM_001005483.1	NP_001005483.1	Q8NGD3	OR4K5_HUMAN	olfactory receptor, family 4, subfamily K, member 5	183					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(6)|liver(1)|lung(27)|ovary(1)|skin(3)|stomach(1)|urinary_tract(1)	47	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		GATCTTCCTCGAGTCACCAAA	0.423000													56	501					7.92265e-33	1.32252e-32	0.870114	1	0
CCDC92	80212	broad.mit.edu	37	12	124421651	124421651	+	Missense_Mutation	SNP	C	C	T			TCGA-55-8096-01A-11D-2238-08	TCGA-55-8096-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	babd96af-bc23-49ee-b8ef-541bc076c7c4	fbc4dd00-fd9b-4988-aa44-ce1598a2150b	g.chr12:124421651C>T	ENST00000545135.1	-	3	4195	c.899G>A	c.(898-900)gGa>gAa	p.G300E	CCDC92_ENST00000545891.1_Missense_Mutation_p.G300E|CCDC92_ENST00000238156.3_Missense_Mutation_p.G317E|CCDC92_ENST00000544798.1_Intron			Q53HC0	CCD92_HUMAN	coiled-coil domain containing 92	317										large_intestine(5)|lung(2)	7	all_neural(191;0.101)|Medulloblastoma(191;0.163)			Epithelial(86;0.0002)|OV - Ovarian serous cystadenocarcinoma(86;0.000222)|all cancers(50;0.00129)|BRCA - Breast invasive adenocarcinoma(302;0.242)		CACCTTGCCTCCGTTCACCTG	0.677000													8	125					0	0	0.307466	0	0
SERPINA7	6906	broad.mit.edu	37	X	105280470	105280470	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8096-01A-11D-2238-08	TCGA-55-8096-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	babd96af-bc23-49ee-b8ef-541bc076c7c4	fbc4dd00-fd9b-4988-aa44-ce1598a2150b	g.chrX:105280470G>T	ENST00000327674.4	-	1	915	c.580C>A	c.(580-582)Cca>Aca	p.P194T	SERPINA7_ENST00000372563.1_Missense_Mutation_p.P194T			P05543	THBG_HUMAN	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7	194					regulation of proteolysis	extracellular space	serine-type endopeptidase inhibitor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(14)|ovary(1)|skin(3)	24					Levothyroxine(DB00451)|Liothyronine(DB00279)	ATGGTGTTTGGCTTGAGGTCT	0.428000													13	171					2.61681e-11	3.46728e-11	0.457914	1	0
TSPAN14	81619	broad.mit.edu	37	10	82277685	82277685	+	Missense_Mutation	SNP	A	A	T			TCGA-55-8096-01A-11D-2238-08	TCGA-55-8096-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	babd96af-bc23-49ee-b8ef-541bc076c7c4	fbc4dd00-fd9b-4988-aa44-ce1598a2150b	g.chr10:82277685A>T	ENST00000429989.2	+	9	989	c.766A>T	c.(766-768)Acg>Tcg	p.T256S	TSPAN14_ENST00000372158.1_Missense_Mutation_p.T256S|TSPAN14_ENST00000481124.1_Missense_Mutation_p.T133S|TSPAN14_ENST00000265450.5_3'UTR|TSPAN14_ENST00000372156.1_Missense_Mutation_p.T256S|TSPAN14_ENST00000341863.6_Missense_Mutation_p.T199S|TSPAN14_ENST00000372164.3_Missense_Mutation_p.T239S	NM_030927.2	NP_112189.2	Q8NG11	TSN14_HUMAN	tetraspanin 14	256						integral to membrane				central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(1)|ovary(1)|skin(1)	7			Colorectal(32;0.229)			CCTGGCAAGGACGCTGATCTC	0.607000													3	6					0	0	0.150653	0	0
CD244	51744	broad.mit.edu	37	1	160808808	160808808	+	Silent	SNP	G	G	T			TCGA-55-8096-01A-11D-2238-08	TCGA-55-8096-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	babd96af-bc23-49ee-b8ef-541bc076c7c4	fbc4dd00-fd9b-4988-aa44-ce1598a2150b	g.chr1:160808808G>T	ENST00000368034.4	-	4	864	c.687C>A	c.(685-687)atC>atA	p.I229I	CD244_ENST00000481677.1_5'UTR|CD244_ENST00000368032.2_Silent_p.I229I|CD244_ENST00000322302.7_Silent_p.I137I|CD244_ENST00000368033.3_Silent_p.I234I	NM_001166663.1|NM_001166664.1|NM_016382.3	NP_001160135.1|NP_001160136.1|NP_057466.1	Q9BZW8	CD244_HUMAN	CD244 molecule, natural killer cell receptor 2B4	234					blood coagulation|leukocyte migration	integral to membrane|plasma membrane	protein binding|receptor activity			central_nervous_system(1)|large_intestine(3)|lung(12)|ovary(1)|urinary_tract(1)	18	all_cancers(52;2.72e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00737)			TTAGAATCACGATGATCACCA	0.517000													9	72					1.08611e-07	1.33869e-07	0.387290	1	0
JAKMIP3	282973	broad.mit.edu	37	10	133948565	133948565	+	Silent	SNP	A	A	G			TCGA-55-8096-01A-11D-2238-08	TCGA-55-8096-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	babd96af-bc23-49ee-b8ef-541bc076c7c4	fbc4dd00-fd9b-4988-aa44-ce1598a2150b	g.chr10:133948565A>G	ENST00000298622.4	+	4	1008	c.870A>G	c.(868-870)aaA>aaG	p.K290K		NM_001105521.2	NP_001098991.1			Janus kinase and microtubule interacting protein 3											breast(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(7)|lung(10)|ovary(2)|prostate(1)|upper_aerodigestive_tract(2)	31		all_cancers(35;5.63e-09)|all_epithelial(44;9.25e-07)|Lung NSC(174;0.0108)|all_lung(145;0.0173)|Colorectal(31;0.0721)|all_neural(114;0.0726)|Breast(234;0.0949)|Glioma(114;0.172)|Melanoma(40;0.175)		OV - Ovarian serous cystadenocarcinoma(35;0.000104)|Epithelial(32;0.000142)|all cancers(32;0.000185)|BRCA - Breast invasive adenocarcinoma(275;0.224)		TGGATGAAAAAGATGCCCGGC	0.498000													3	64					0	0	0.115264	0	0
MTMR12	54545	broad.mit.edu	37	5	32235101	32235101	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8096-01A-11D-2238-08	TCGA-55-8096-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	babd96af-bc23-49ee-b8ef-541bc076c7c4	fbc4dd00-fd9b-4988-aa44-ce1598a2150b	g.chr5:32235101G>T	ENST00000382142.3	-	14	1649	c.1479C>A	c.(1477-1479)ttC>ttA	p.F493L	MTMR12_ENST00000264934.5_Intron|MTMR12_ENST00000280285.5_Missense_Mutation_p.F493L	NM_001040446.1	NP_001035536.1	Q9C0I1	MTMRC_HUMAN	myotubularin related protein 12	493	Interaction with MTM1.|Myotubularin phosphatase.					cytoplasm	phosphatase activity			breast(3)|endometrium(3)|kidney(2)|large_intestine(7)|lung(11)|ovary(2)|prostate(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	34						GTGAATTGAAGAAGAAGGTGC	0.423000													15	66					1.52009e-12	2.10627e-12	0.479597	1	0
UNC79	57578	broad.mit.edu	37	14	94038260	94038260	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8096-01A-11D-2238-08	TCGA-55-8096-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	babd96af-bc23-49ee-b8ef-541bc076c7c4	fbc4dd00-fd9b-4988-aa44-ce1598a2150b	g.chr14:94038260G>T	ENST00000553484.1	+	15	1930	c.1776G>T	c.(1774-1776)aaG>aaT	p.K592N	UNC79_ENST00000256339.4_Missense_Mutation_p.K415N|UNC79_ENST00000393151.2_Missense_Mutation_p.K592N|UNC79_ENST00000555664.1_Missense_Mutation_p.K592N			Q9P2D8	UNC79_HUMAN	unc-79 homolog (C. elegans)	592						integral to membrane				breast(3)|cervix(2)|endometrium(10)|kidney(7)|large_intestine(18)|liver(1)|lung(64)|ovary(1)|prostate(5)|skin(3)|urinary_tract(4)	118						ACTGGGATAAGTCCTGTAGCA	0.453000													7	63					0.0293803	0.0311432	0.248553	1	0
RSRC2	65117	broad.mit.edu	37	12	123003576	123003576	+	Missense_Mutation	SNP	C	C	T			TCGA-55-8096-01A-11D-2238-08	TCGA-55-8096-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	babd96af-bc23-49ee-b8ef-541bc076c7c4	fbc4dd00-fd9b-4988-aa44-ce1598a2150b	g.chr12:123003576C>T	ENST00000354654.2	-	4	375	c.64G>A	c.(64-66)Gga>Aga	p.G22R	RSRC2_ENST00000331738.7_Splice_Site_p.G70_splice			Q7L4I2	RSRC2_HUMAN	arginine/serine-rich coiled-coil 2	70										breast(2)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(7)|ovary(1)|skin(2)|urinary_tract(2)	24	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;5.14e-05)|Epithelial(86;0.000183)|BRCA - Breast invasive adenocarcinoma(302;0.201)		TGTCTTCTTCCCTGTTTTAAG	0.343000													6	33					0	0	0.217242	0	0
NLRP7	199713	broad.mit.edu	37	19	55450747	55450747	+	Nonsense_Mutation	SNP	G	G	T			TCGA-55-8096-01A-11D-2238-08	TCGA-55-8096-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	babd96af-bc23-49ee-b8ef-541bc076c7c4	fbc4dd00-fd9b-4988-aa44-ce1598a2150b	g.chr19:55450747G>T	ENST00000446217.1	-	6	1926	c.1524C>A	c.(1522-1524)taC>taA	p.Y508*	NLRP7_ENST00000340844.2_Nonsense_Mutation_p.Y480*|NLRP7_ENST00000592784.1_Nonsense_Mutation_p.Y480*|NLRP7_ENST00000328092.5_Nonsense_Mutation_p.Y480*|NLRP7_ENST00000448121.2_Nonsense_Mutation_p.Y480*|NLRP7_ENST00000590030.1_Nonsense_Mutation_p.Y480*|NLRP7_ENST00000588756.1_Nonsense_Mutation_p.Y480*			Q8WX94	NALP7_HUMAN	NLR family, pyrin domain containing 7	480							ATP binding			autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(17)|liver(1)|lung(33)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	73				GBM - Glioblastoma multiforme(193;0.0325)		TCTCCAGGGCGTAGAACAGGG	0.592000													9	36					0.0692343	0.0723038	0.361761	1	0
C2	717	broad.mit.edu	37	6	31903772	31903772	+	Missense_Mutation	SNP	G	G	C			TCGA-55-8096-01A-11D-2238-08	TCGA-55-8096-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	babd96af-bc23-49ee-b8ef-541bc076c7c4	fbc4dd00-fd9b-4988-aa44-ce1598a2150b	g.chr6:31903772G>C	ENST00000299367.5	+	7	1198	c.922G>C	c.(922-924)Gtc>Ctc	p.V308L	CFB_ENST00000456570.1_Intron|CFB_ENST00000556679.1_Intron|C2_ENST00000452323.2_Intron|C2_ENST00000469372.1_Missense_Mutation_p.V62L|CFB_ENST00000477310.1_Intron|C2_ENST00000442278.2_Missense_Mutation_p.V176L	NM_000063.4	NP_000054.2			complement component 2											haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(12)|ovary(1)|skin(2)|urinary_tract(2)	27		Ovarian(999;0.00965)		LUAD - Lung adenocarcinoma(999;0.247)		CCTCATGTCTGTCCTGAACGA	0.507000													18	54					0	0	0.539581	0	0
NPAP1	23742	broad.mit.edu	37	15	24921733	24921733	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8096-01A-11D-2238-08	TCGA-55-8096-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	babd96af-bc23-49ee-b8ef-541bc076c7c4	fbc4dd00-fd9b-4988-aa44-ce1598a2150b	g.chr15:24921733C>A	ENST00000329468.2	+	1	1193	c.719C>A	c.(718-720)cCc>cAc	p.P240H		NM_018958.2	NP_061831.2			nuclear pore associated protein 1																		CCTGCCATGCCCAGCACACAC	0.617000													27	63					3.90053e-15	5.70284e-15	0.760397	1	0
AGL	178	broad.mit.edu	37	1	100329996	100329996	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8096-01A-11D-2238-08	TCGA-55-8096-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	babd96af-bc23-49ee-b8ef-541bc076c7c4	fbc4dd00-fd9b-4988-aa44-ce1598a2150b	g.chr1:100329996G>T	ENST00000294724.4	+	5	993	c.515G>T	c.(514-516)tGc>tTc	p.C172F	AGL_ENST00000370163.3_Missense_Mutation_p.C172F|AGL_ENST00000361302.3_Missense_Mutation_p.C156F|AGL_ENST00000361522.4_Missense_Mutation_p.C155F|AGL_ENST00000370161.2_Missense_Mutation_p.C156F|AGL_ENST00000370165.3_Missense_Mutation_p.C172F|AGL_ENST00000361915.3_Missense_Mutation_p.C172F	NM_000028.2	NP_000019.2	P35573	GDE_HUMAN	amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase	172					glucose metabolic process|glycogen biosynthetic process|glycogen catabolic process	cytosol|isoamylase complex|nucleus	4-alpha-glucanotransferase activity|amylo-alpha-1,6-glucosidase activity|cation binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(6)|large_intestine(9)|lung(35)|ovary(1)|prostate(4)|skin(3)|urinary_tract(1)	69		all_epithelial(167;2.2e-06)|all_lung(203;0.000295)|Lung NSC(277;0.00131)		Epithelial(280;0.15)|COAD - Colon adenocarcinoma(174;0.151)|Lung(183;0.209)|all cancers(265;0.237)		TCTAGGTCATGCTACTCCCTT	0.363000													19	98					1.5548e-18	2.38853e-18	0.693898	1	0
CSMD3	114788	broad.mit.edu	37	8	113259343	113259343	+	Missense_Mutation	SNP	C	C	G			TCGA-55-8096-01A-11D-2238-08	TCGA-55-8096-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	babd96af-bc23-49ee-b8ef-541bc076c7c4	fbc4dd00-fd9b-4988-aa44-ce1598a2150b	g.chr8:113259343C>G	ENST00000297405.5	-	64	10372	c.10128G>C	c.(10126-10128)caG>caC	p.Q3376H	CSMD3_ENST00000455883.2_Missense_Mutation_p.Q3207H|CSMD3_ENST00000352409.3_Missense_Mutation_p.Q3306H|CSMD3_ENST00000343508.3_Missense_Mutation_p.Q3336H	NM_198123.1	NP_937756.1	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3	3376	Sushi 27.					integral to membrane|plasma membrane				breast(7)|central_nervous_system(6)|endometrium(44)|haematopoietic_and_lymphoid_tissue(8)|kidney(36)|large_intestine(72)|liver(5)|lung(389)|ovary(24)|prostate(6)|skin(23)|upper_aerodigestive_tract(19)|urinary_tract(7)	646						TGCAATGGAACTGTACAACAC	0.418000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			4	42					0	0	0.217242	0	0
THSD7A	221981	broad.mit.edu	37	7	11450930	11450930	+	Silent	SNP	C	C	G			TCGA-55-8096-01A-11D-2238-08	TCGA-55-8096-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	babd96af-bc23-49ee-b8ef-541bc076c7c4	fbc4dd00-fd9b-4988-aa44-ce1598a2150b	g.chr7:11450930C>G	ENST00000423059.3	-	19	3953	c.3702G>C	c.(3700-3702)ctG>ctC	p.L1234L	AC004538.3_ENST00000445839.1_RNA|AC004160.4_ENST00000425837.1_RNA	NM_015204.2	NP_056019.1	Q9UPZ6	THS7A_HUMAN	thrombospondin, type I, domain containing 7A	1234	TSP type-1 12.					integral to membrane				NS(1)|autonomic_ganglia(1)|breast(5)|cervix(1)|endometrium(8)|kidney(2)|large_intestine(7)|lung(68)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(11)	113				UCEC - Uterine corpus endometrioid carcinoma (126;0.163)		CCTTCTCACTCAGCTGACATG	0.413000										HNSCC(18;0.044)			8	63					0	0	0.361761	0	0
LMTK2	22853	broad.mit.edu	37	7	97821988	97821988	+	Silent	SNP	C	C	T			TCGA-55-8096-01A-11D-2238-08	TCGA-55-8096-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	babd96af-bc23-49ee-b8ef-541bc076c7c4	fbc4dd00-fd9b-4988-aa44-ce1598a2150b	g.chr7:97821988C>T	ENST00000297293.5	+	11	2504	c.2211C>T	c.(2209-2211)tcC>tcT	p.S737S		NM_014916.3	NP_055731.2	Q8IWU2	LMTK2_HUMAN	lemur tyrosine kinase 2	737					early endosome to late endosome transport|endocytic recycling|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|protein autophosphorylation|receptor recycling|transferrin transport	early endosome|Golgi apparatus|integral to membrane|perinuclear region of cytoplasm|recycling endosome	ATP binding|myosin VI binding|protein phosphatase inhibitor activity|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(2)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(13)|lung(25)|ovary(1)|pancreas(2)|skin(2)|stomach(3)	59	all_cancers(62;3.23e-09)|all_epithelial(64;7.65e-10)|Lung NSC(181;0.00902)|all_lung(186;0.0104)|Esophageal squamous(72;0.0125)					GCTCATTGTCCAGCAAAGAAC	0.323000													7	31					0	0	0.278610	0	0
ZNF492	57615	broad.mit.edu	37	19	22836767	22836767	+	Missense_Mutation	SNP	G	G	T	rs111905502		TCGA-55-8096-01A-11D-2238-08	TCGA-55-8096-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	babd96af-bc23-49ee-b8ef-541bc076c7c4	fbc4dd00-fd9b-4988-aa44-ce1598a2150b	g.chr19:22836767G>T	ENST00000456783.2	+	3	324	c.80G>T	c.(79-81)gGa>gTa	p.G27V		NM_020855.2	NP_065906.1	Q9P255	ZN492_HUMAN	zinc finger protein 492	27	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|kidney(1)|large_intestine(6)|lung(10)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	21		all_cancers(12;0.0266)|all_lung(12;0.00187)|Lung NSC(12;0.0019)|all_epithelial(12;0.00203)|Hepatocellular(1079;0.244)				CTGGAGCAAGGAAAAGAACCT	0.423000													14	113					1.33834e-09	1.7092e-09	0.557998	1	0
OR5H6	79295	broad.mit.edu	37	3	97983585	97983585	+	Missense_Mutation	SNP	A	A	T			TCGA-55-8096-01A-11D-2238-08	TCGA-55-8096-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	babd96af-bc23-49ee-b8ef-541bc076c7c4	fbc4dd00-fd9b-4988-aa44-ce1598a2150b	g.chr3:97983585A>T	ENST00000383696.2	+	1	498	c.457A>T	c.(457-459)Acc>Tcc	p.T153S	RP11-325B23.2_ENST00000508616.1_lincRNA	NM_001005479.1	NP_001005479.1	Q8NGV6	OR5H6_HUMAN	olfactory receptor, family 5, subfamily H, member 6 (gene/pseudogene)	153					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(2)|endometrium(1)|large_intestine(4)|lung(20)|ovary(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	34						AGTCATTATGACCAATGAACT	0.368000													11	75					0	0	0.457914	0	0
MIB1	57534	broad.mit.edu	37	18	19429241	19429241	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8096-01A-11D-2238-08	TCGA-55-8096-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	babd96af-bc23-49ee-b8ef-541bc076c7c4	fbc4dd00-fd9b-4988-aa44-ce1598a2150b	g.chr18:19429241G>T	ENST00000261537.6	+	17	2742	c.2478G>T	c.(2476-2478)aaG>aaT	p.K826N	MIB1_ENST00000578646.1_3'UTR	NM_020774.2	NP_065825.1	Q86YT6	MIB1_HUMAN	mindbomb E3 ubiquitin protein ligase 1	826					Notch signaling pathway	centrosome|nuclear membrane|plasma membrane	ubiquitin-protein ligase activity|zinc ion binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(13)|ovary(5)	27			STAD - Stomach adenocarcinoma(5;0.212)			CAGATATGAAGAGAGATACTC	0.388000													13	197					1.52009e-12	2.10627e-12	0.479597	1	0
TRPC5	7224	broad.mit.edu	37	X	111078272	111078272	+	Missense_Mutation	SNP	T	T	A			TCGA-55-8096-01A-11D-2238-08	TCGA-55-8096-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	babd96af-bc23-49ee-b8ef-541bc076c7c4	fbc4dd00-fd9b-4988-aa44-ce1598a2150b	g.chrX:111078272T>A	ENST00000262839.2	-	7	2691	c.1773A>T	c.(1771-1773)aaA>aaT	p.K591N		NM_012471.2	NP_036603.1	Q9UL62	TRPC5_HUMAN	transient receptor potential cation channel, subfamily C, member 5	591					axon guidance	calcium channel complex|integral to plasma membrane	protein binding|store-operated calcium channel activity			biliary_tract(1)|breast(4)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(38)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	62						CGTGTCTGGCTTTCACATTGG	0.418000													42	489					0	0	0.870114	0	0
OTOGL	283310	broad.mit.edu	37	12	80626733	80626733	+	Missense_Mutation	SNP	G	G	C			TCGA-55-8096-01A-11D-2238-08	TCGA-55-8096-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	babd96af-bc23-49ee-b8ef-541bc076c7c4	fbc4dd00-fd9b-4988-aa44-ce1598a2150b	g.chr12:80626733G>C	ENST00000458043.2	+	8	652	c.646G>C	c.(646-648)Gtg>Ctg	p.V216L	OTOGL_ENST00000547103.1_Missense_Mutation_p.V216L	NM_173591.3	NP_775862.3			otogelin-like											breast(1)|endometrium(3)|kidney(2)|large_intestine(2)|lung(14)|prostate(1)	23						CTACATTCTTGTGAAAACAAC	0.403000													4	21					0	0	0.217242	0	0
DRAXIN	374946	broad.mit.edu	37	1	11769352	11769352	+	Missense_Mutation	SNP	C	C	T			TCGA-55-8096-01A-11D-2238-08	TCGA-55-8096-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	babd96af-bc23-49ee-b8ef-541bc076c7c4	fbc4dd00-fd9b-4988-aa44-ce1598a2150b	g.chr1:11769352C>T	ENST00000294485.5	+	3	607	c.472C>T	c.(472-474)Ccc>Tcc	p.P158S		NM_198545.3	NP_940947.3			dorsal inhibitory axon guidance protein																		GGTCCGAGGTCCCAGCTCCCT	0.597000													13	37					0	0	0.500413	0	0
NKD1	85407	broad.mit.edu	37	16	50659416	50659416	+	Silent	SNP	C	C	A			TCGA-55-8096-01A-11D-2238-08	TCGA-55-8096-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	babd96af-bc23-49ee-b8ef-541bc076c7c4	fbc4dd00-fd9b-4988-aa44-ce1598a2150b	g.chr16:50659416C>A	ENST00000268459.3	+	6	611	c.387C>A	c.(385-387)tcC>tcA	p.S129S		NM_033119.4	NP_149110.1	Q969G9	NKD1_HUMAN	naked cuticle homolog 1 (Drosophila)	129	Interaction with DVL1, DVL2 and DVL3 (By similarity).				Wnt receptor signaling pathway	cytoplasm|plasma membrane	calcium ion binding|protein binding			NS(1)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(5)|lung(9)|prostate(1)|urinary_tract(2)	23		all_cancers(37;0.229)		GBM - Glioblastoma multiforme(240;0.243)		GCGACGTGTCCATGGAGGAGG	0.612000													18	120					1.55795e-14	2.24683e-14	0.608945	1	0
RAB11FIP1	80223	broad.mit.edu	37	8	37729120	37729120	+	Missense_Mutation	SNP	G	G	C			TCGA-55-8096-01A-11D-2238-08	TCGA-55-8096-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	babd96af-bc23-49ee-b8ef-541bc076c7c4	fbc4dd00-fd9b-4988-aa44-ce1598a2150b	g.chr8:37729120G>C	ENST00000330843.4	-	4	3212	c.3200C>G	c.(3199-3201)cCa>cGa	p.P1067R	RAB11FIP1_ENST00000523182.1_5'UTR|RAB11FIP1_ENST00000522727.1_Intron|RAB11FIP1_ENST00000524118.1_Intron|RAB11FIP1_ENST00000287263.4_Intron	NM_001002814.2	NP_001002814.2	Q6WKZ4	RFIP1_HUMAN	RAB11 family interacting protein 1 (class I)	1067					protein transport	centrosome|phagocytic vesicle membrane|recycling endosome	protein binding			NS(1)|breast(1)|central_nervous_system(4)|endometrium(3)|large_intestine(6)|lung(20)|ovary(3)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	49		Lung NSC(58;0.118)|all_lung(54;0.195)	LUSC - Lung squamous cell carcinoma(8;3.62e-11)			ACTGGGGCCTGGCAGCTGTTT	0.567000											OREG0018713	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	24	302					0	0	0.681144	0	0
LOC101927060	101927060	broad.mit.edu	37	17	45127107	45127107	+	RNA	SNP	C	C	G	rs147409399	by1000genomes	TCGA-55-8096-01A-11D-2238-08	TCGA-55-8096-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	babd96af-bc23-49ee-b8ef-541bc076c7c4	fbc4dd00-fd9b-4988-aa44-ce1598a2150b	g.chr17:45127107C>G	ENST00000575173.1	-	0	418																											CCTTCGTTCACCCAAGAGCAT	0.592000													4	75					0	0	0.150653	0	0
CHST6	4166	broad.mit.edu	37	16	75512743	75512743	+	Silent	SNP	G	G	A	rs112748405		TCGA-55-8096-01A-11D-2238-08	TCGA-55-8096-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	babd96af-bc23-49ee-b8ef-541bc076c7c4	fbc4dd00-fd9b-4988-aa44-ce1598a2150b	g.chr16:75512743G>A	ENST00000332272.4	-	3	1163	c.984C>T	c.(982-984)aaC>aaT	p.N328N	CHST6_ENST00000390664.2_Silent_p.N328N|RP11-77K12.4_ENST00000530512.3_RNA	NM_021615.4	NP_067628.1	Q9GZX3	CHST6_HUMAN	carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 6	328					keratan sulfate biosynthetic process|N-acetylglucosamine metabolic process	Golgi membrane|integral to membrane	N-acetylglucosamine 6-O-sulfotransferase activity			central_nervous_system(1)|cervix(1)|endometrium(1)|large_intestine(1)|lung(7)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	17						CCTGGGAGACGTTGAGCGCAT	0.647000													18	102					0	0	0.624587	0	0
MYH7	4625	broad.mit.edu	37	14	23885030	23885030	+	Silent	SNP	A	A	G			TCGA-55-8096-01A-11D-2238-08	TCGA-55-8096-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	babd96af-bc23-49ee-b8ef-541bc076c7c4	fbc4dd00-fd9b-4988-aa44-ce1598a2150b	g.chr14:23885030A>G	ENST00000355349.3	-	35	5127	c.4965T>C	c.(4963-4965)atT>atC	p.I1655I		NM_000257.2	NP_000248.2	P12883	MYH7_HUMAN	myosin, heavy chain 7, cardiac muscle, beta	1655					adult heart development|muscle filament sliding|regulation of heart rate|ventricular cardiac muscle tissue morphogenesis	focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(3)|breast(4)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(19)|lung(57)|ovary(5)|prostate(9)|skin(5)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(5)	137	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00725)		CGTCCAGCTGAATCTGGGTGT	0.597000													6	81					0	0	0.217242	0	0
TRIM58	25893	broad.mit.edu	37	1	248039575	248039575	+	Missense_Mutation	SNP	G	G	C			TCGA-55-8096-01A-11D-2238-08	TCGA-55-8096-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	babd96af-bc23-49ee-b8ef-541bc076c7c4	fbc4dd00-fd9b-4988-aa44-ce1598a2150b	g.chr1:248039575G>C	ENST00000366481.3	+	6	1293	c.1245G>C	c.(1243-1245)ttG>ttC	p.L415F	OR2W3_ENST00000537741.1_Intron	NM_015431.3	NP_056246.3	Q8NG06	TRI58_HUMAN	tripartite motif containing 58	415	B30.2/SPRY.					intracellular	zinc ion binding	p.L415L(1)		NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(4)|lung(39)|ovary(4)|pancreas(1)|skin(7)|stomach(1)	63	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)	all_cancers(173;0.0286)	OV - Ovarian serous cystadenocarcinoma(106;0.0319)			GGATTTTCTTGGACTATGAAG	0.468000													34	207					0	0	0.819951	0	0
SPATA17	128153	broad.mit.edu	37	1	218036183	218036183	+	Missense_Mutation	SNP	G	G	C			TCGA-55-8096-01A-11D-2238-08	TCGA-55-8096-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	babd96af-bc23-49ee-b8ef-541bc076c7c4	fbc4dd00-fd9b-4988-aa44-ce1598a2150b	g.chr1:218036183G>C	ENST00000366933.4	+	10	1128	c.1073G>C	c.(1072-1074)gGa>gCa	p.G358A	SPATA17_ENST00000471021.1_3'UTR	NM_138796.2	NP_620151.1	Q96L03	SPT17_HUMAN	spermatogenesis associated 17	358						cytoplasm	calmodulin binding			endometrium(1)|kidney(1)|large_intestine(9)|lung(6)|pancreas(2)|prostate(1)|urinary_tract(1)	21				OV - Ovarian serous cystadenocarcinoma(81;0.0516)|all cancers(67;0.0891)|GBM - Glioblastoma multiforme(131;0.117)		TCAAAAGCTGGACAGATTGTA	0.308000													13	178					0	0	0.435327	0	0
DDR1	780	broad.mit.edu	37	6	30866958	30866958	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8096-01A-11D-2238-08	TCGA-55-8096-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	babd96af-bc23-49ee-b8ef-541bc076c7c4	fbc4dd00-fd9b-4988-aa44-ce1598a2150b	g.chr6:30866958G>T	ENST00000324771.8	+	20	3175	c.2627G>T	c.(2626-2628)tGc>tTc	p.C876F	DDR1_ENST00000376570.4_Missense_Mutation_p.C839F|DDR1_ENST00000376567.2_Missense_Mutation_p.C839F|DDR1_ENST00000361741.4_Intron|DDR1_ENST00000454612.2_Missense_Mutation_p.C839F|DDR1_ENST00000376575.3_Missense_Mutation_p.C882F|DDR1_ENST00000452441.1_Missense_Mutation_p.C876F|DDR1_ENST00000513240.1_Missense_Mutation_p.C882F|DDR1_ENST00000376569.3_Missense_Mutation_p.C839F|DDR1_ENST00000508312.1_Missense_Mutation_p.C857F|DDR1_ENST00000446312.1_3'UTR|DDR1_ENST00000376568.3_Missense_Mutation_p.C876F|DDR1_ENST00000418800.2_Missense_Mutation_p.C839F			Q08345	DDR1_HUMAN	discoidin domain receptor tyrosine kinase 1	876	Protein kinase.				cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	extracellular region|integral to plasma membrane	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity			central_nervous_system(3)|endometrium(2)|kidney(1)|large_intestine(5)|liver(1)|lung(14)|ovary(1)|prostate(1)|skin(1)	29					Imatinib(DB00619)	CCGCCTGCCTGCCCGCAGGGC	0.577000													47	144					9.55421e-19	1.48933e-18	0.870114	1	0
DKK1	22943	broad.mit.edu	37	10	54076112	54076112	+	Missense_Mutation	SNP	C	C	T			TCGA-55-8096-01A-11D-2238-08	TCGA-55-8096-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	babd96af-bc23-49ee-b8ef-541bc076c7c4	fbc4dd00-fd9b-4988-aa44-ce1598a2150b	g.chr10:54076112C>T	ENST00000373970.3	+	3	603	c.464C>T	c.(463-465)aCt>aTt	p.T155I	DKK1_ENST00000467359.1_3'UTR	NM_012242.2	NP_036374.1	O94907	DKK1_HUMAN	dickkopf WNT signaling pathway inhibitor 1	155					negative regulation of peptidyl-serine phosphorylation|negative regulation of protein complex assembly|negative regulation of transcription from RNA polymerase II promoter|positive regulation of heart induction by negative regulation of canonical Wnt receptor signaling pathway|regulation of receptor internalization	extracellular space|plasma membrane	growth factor activity|low-density lipoprotein particle receptor binding|receptor antagonist activity|signal transducer activity			kidney(2)|large_intestine(4)|lung(7)|ovary(1)|upper_aerodigestive_tract(2)	16						GAAACCATCACTGAAAGCTTT	0.388000													10	42					0	0	0.361761	0	0
FMN2	56776	broad.mit.edu	37	1	240601428	240601428	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8096-01A-11D-2238-08	TCGA-55-8096-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	babd96af-bc23-49ee-b8ef-541bc076c7c4	fbc4dd00-fd9b-4988-aa44-ce1598a2150b	g.chr1:240601428G>A	ENST00000319653.9	+	16	5208	c.4978G>A	c.(4978-4980)Gct>Act	p.A1660T	FMN2_ENST00000545751.1_Missense_Mutation_p.A256T	NM_020066.4	NP_064450.3	Q9NZ56	FMN2_HUMAN	formin 2	1660	FH2.				actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			NS(1)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(13)|lung(87)|ovary(6)|pancreas(3)|prostate(12)|skin(7)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(2)	178	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			GTCCCCAAATGCTTTCTTCAG	0.388000													20	99					0	0	0.639603	0	0
GPR158	57512	broad.mit.edu	37	10	25888106	25888106	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8096-01A-11D-2238-08	TCGA-55-8096-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	babd96af-bc23-49ee-b8ef-541bc076c7c4	fbc4dd00-fd9b-4988-aa44-ce1598a2150b	g.chr10:25888106C>A	ENST00000376351.3	+	11	3910	c.3551C>A	c.(3550-3552)gCt>gAt	p.A1184D	GPR158_ENST00000490549.1_3'UTR	NM_020752.2	NP_065803.2	Q5T848	GP158_HUMAN	G protein-coupled receptor 158	1184						integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(5)|cervix(1)|endometrium(9)|kidney(10)|large_intestine(20)|lung(56)|ovary(4)|pancreas(1)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	119						CAACCAAATGCTGGAAGAAGT	0.448000													5	44					0.00116845	0.00129691	0.217242	1	0
MLST8	64223	broad.mit.edu	37	16	2258335	2258335	+	Splice_Site	SNP	C	C	T			TCGA-55-8096-01A-11D-2238-08	TCGA-55-8096-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	babd96af-bc23-49ee-b8ef-541bc076c7c4	fbc4dd00-fd9b-4988-aa44-ce1598a2150b	g.chr16:2258335C>T	ENST00000569417.1	+	7	1052	c.698_splice	c.e7+1	p.T233_splice	MLST8_ENST00000382450.4_Splice_Site_p.T232_splice|MLST8_ENST00000561651.1_Intron|MLST8_ENST00000564088.1_Splice_Site_p.T233_splice|MLST8_ENST00000565250.1_Splice_Site_p.T233_splice|MLST8_ENST00000301724.10_Splice_Site_p.T233_splice|MLST8_ENST00000301725.7_Intron|MLST8_ENST00000397124.1_Splice_Site_p.T233_splice	NM_022372.4	NP_071767.3	Q9BVC4	LST8_HUMAN	MTOR associated protein, LST8 homolog (S. cerevisiae)	233					insulin receptor signaling pathway|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of TOR signaling cascade|T cell costimulation	cytosol	protein binding			large_intestine(3)|lung(2)|skin(1)	6						CCCGACTCCACGTGCGTGCAG	0.697000													18	265					0	0	0.624587	0	0
SPRYD7	57213	broad.mit.edu	37	13	50502073	50502073	+	Silent	SNP	C	C	A			TCGA-55-8096-01A-11D-2238-08	TCGA-55-8096-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	babd96af-bc23-49ee-b8ef-541bc076c7c4	fbc4dd00-fd9b-4988-aa44-ce1598a2150b	g.chr13:50502073C>A	ENST00000378195.2	-	2	509	c.255G>T	c.(253-255)ccG>ccT	p.P85P	SPRYD7_ENST00000361840.3_Silent_p.P124P	NM_001127482.1	NP_001120954.1	Q5W111	SPRY7_HUMAN	SPRY domain containing 7	124	B30.2/SPRY.									haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(1)|lung(2)	6						CTCCTTCCTGCGGAAGACTGT	0.448000													6	71					0.0381472	0.0400357	0.278610	1	0
ENOX2	10495	broad.mit.edu	37	X	129759318	129759318	+	Silent	SNP	G	G	A			TCGA-55-8096-01A-11D-2238-08	TCGA-55-8096-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	babd96af-bc23-49ee-b8ef-541bc076c7c4	fbc4dd00-fd9b-4988-aa44-ce1598a2150b	g.chrX:129759318G>A	ENST00000338144.3	-	16	2220	c.1803C>T	c.(1801-1803)ttC>ttT	p.F601F	ENOX2_ENST00000370927.1_Silent_p.F601F|ENOX2_ENST00000394363.1_Silent_p.F572F|ENOX2_ENST00000370935.1_Silent_p.F572F	NM_182314.1	NP_872114.1	Q16206	ENOX2_HUMAN	ecto-NOX disulfide-thiol exchanger 2	601					cell growth|electron transport chain|regulation of growth|transport|ultradian rhythm	cytosol|external side of plasma membrane|extracellular space	nucleic acid binding|nucleotide binding|protein disulfide oxidoreductase activity			breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(17)|ovary(1)|prostate(3)	33						CGAAGCCACAGAATTTCCATC	0.453000													18	72					0	0	0.654019	0	0
U2AF2	11338	broad.mit.edu	37	19	56166500	56166500	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8096-01A-11D-2238-08	TCGA-55-8096-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	babd96af-bc23-49ee-b8ef-541bc076c7c4	fbc4dd00-fd9b-4988-aa44-ce1598a2150b	g.chr19:56166500G>T	ENST00000450554.2	+	1	989	c.30G>T	c.(28-30)caG>caT	p.Q10H	U2AF2_ENST00000308924.4_Missense_Mutation_p.Q10H	NM_001012478.1|NM_007279.2	NP_001012496.1|NP_009210.1	P26368	U2AF2_HUMAN	U2 small nuclear RNA auxiliary factor 2	10					mRNA 3'-end processing|mRNA export from nucleus|termination of RNA polymerase II transcription	nucleoplasm|spliceosomal complex	enzyme binding|nucleotide binding|RNA binding			biliary_tract(1)|central_nervous_system(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(3)|lung(9)|ovary(1)|prostate(1)|urinary_tract(2)	21		Colorectal(82;0.00244)|Ovarian(87;0.133)	BRCA - Breast invasive adenocarcinoma(297;0.18)	GBM - Glioblastoma multiforme(193;0.107)		TCGAGCGGCAGCTCAACGAGA	0.682000													4	52					0.00198382	0.00215677	0.248553	1	0
CACNG4	27092	broad.mit.edu	37	17	65026879	65026879	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8096-01A-11D-2238-08	TCGA-55-8096-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	babd96af-bc23-49ee-b8ef-541bc076c7c4	fbc4dd00-fd9b-4988-aa44-ce1598a2150b	g.chr17:65026879G>A	ENST00000262138.3	+	4	745	c.743G>A	c.(742-744)aGg>aAg	p.R248K		NM_014405.3	NP_055220.1	Q9UBN1	CCG4_HUMAN	calcium channel, voltage-dependent, gamma subunit 4	248					membrane depolarization|regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|endocytic vesicle membrane	voltage-gated calcium channel activity			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(8)|ovary(1)|prostate(3)	19	all_cancers(12;9.86e-11)		BRCA - Breast invasive adenocarcinoma(6;1.35e-07)			TCCAGCTCAAGGTCCACCGAG	0.612000													34	65					0	0	0.812448	0	0
MIR523	574471	broad.mit.edu	37	19	54201697	54201697	+	RNA	SNP	G	G	T			TCGA-55-8096-01A-11D-2238-08	TCGA-55-8096-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	babd96af-bc23-49ee-b8ef-541bc076c7c4	fbc4dd00-fd9b-4988-aa44-ce1598a2150b	g.chr19:54201697G>T	ENST00000385281.1	+	0	59					NR_030193.1																						AAAAGAACGCGCTTCCCTATA	0.443000													16	41					2.31682e-05	2.79072e-05	0.479597	1	0
THPO	7066	broad.mit.edu	37	3	184090731	184090731	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8096-01A-11D-2238-08	TCGA-55-8096-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	babd96af-bc23-49ee-b8ef-541bc076c7c4	fbc4dd00-fd9b-4988-aa44-ce1598a2150b	g.chr3:184090731G>T	ENST00000204615.7	-	6	846	c.632C>A	c.(631-633)gCc>gAc	p.A211D	THPO_ENST00000421442.2_Missense_Mutation_p.S172R|THPO_ENST00000477594.1_5'UTR|EIF2B5_ENST00000444495.1_Intron|THPO_ENST00000445696.2_Missense_Mutation_p.A207D	NM_000460.2|NM_001177597.1|NM_001177598.1	NP_000451.1|NP_001171068.1|NP_001171069.1	P40225	TPO_HUMAN	thrombopoietin	211					cell proliferation|platelet activation	extracellular space	cytokine activity|growth factor activity|hormone activity			NS(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(6)|ovary(1)|prostate(1)|skin(1)	16	all_cancers(143;6.33e-11)|Ovarian(172;0.0339)		Epithelial(37;4.96e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			AGTAGTTCTGGCTGAGGCAGT	0.552000													7	41					0.00198382	0.00215677	0.248553	1	0
HSPA12A	259217	broad.mit.edu	37	10	118440687	118440687	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8096-01A-11D-2238-08	TCGA-55-8096-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	babd96af-bc23-49ee-b8ef-541bc076c7c4	fbc4dd00-fd9b-4988-aa44-ce1598a2150b	g.chr10:118440687G>T	ENST00000369209.3	-	9	1107	c.1003C>A	c.(1003-1005)Ctt>Att	p.L335I		NM_025015.2	NP_079291.2	O43301	HS12A_HUMAN	heat shock 70kDa protein 12A	335							ATP binding			breast(2)|endometrium(2)|kidney(1)|large_intestine(5)|lung(15)|ovary(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	32				all cancers(201;0.0158)		AGTTCCTTAAGGTGTCCCTCC	0.488000													5	77					0.014758	0.0158015	0.184627	1	0
COLGALT2	23127	broad.mit.edu	37	1	183938417	183938417	+	Missense_Mutation	SNP	G	G	C			TCGA-55-8096-01A-11D-2238-08	TCGA-55-8096-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	babd96af-bc23-49ee-b8ef-541bc076c7c4	fbc4dd00-fd9b-4988-aa44-ce1598a2150b	g.chr1:183938417G>C	ENST00000361927.4	-	5	1189	c.818C>G	c.(817-819)tCc>tGc	p.S273C	COLGALT2_ENST00000546159.1_Missense_Mutation_p.S273C	NM_015101.2	NP_055916.1			collagen beta(1-O)galactosyltransferase 2																		TTGCCTGCTGGAGAAGGCAAA	0.458000													13	101					0	0	0.479597	0	0
LRRK1	79705	broad.mit.edu	37	15	101606941	101606941	+	Silent	SNP	G	G	T			TCGA-55-8096-01A-11D-2238-08	TCGA-55-8096-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	babd96af-bc23-49ee-b8ef-541bc076c7c4	fbc4dd00-fd9b-4988-aa44-ce1598a2150b	g.chr15:101606941G>T	ENST00000284395.5	+	34	6256	c.5856G>T	c.(5854-5856)ccG>ccT	p.P1952P	LRRK1_ENST00000532145.1_3'UTR|RP11-505E24.2_ENST00000559857.1_RNA|LRRK1_ENST00000388948.3_Silent_p.P1955P			Q38SD2	LRRK1_HUMAN	leucine-rich repeat kinase 1	1955					small GTPase mediated signal transduction	mitochondrion	ATP binding|GTP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(6)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(14)|lung(25)|ovary(4)|prostate(1)|skin(1)	72	Melanoma(26;0.00505)|Lung NSC(78;0.00793)|all_lung(78;0.0094)		OV - Ovarian serous cystadenocarcinoma(32;0.000932)|LUSC - Lung squamous cell carcinoma(107;0.187)|Lung(145;0.23)			AGCTGACTCCGCATGGGTAAG	0.597000													48	130					2.43468e-25	3.9704e-25	0.870114	1	0
PALB2	79728	broad.mit.edu	37	16	23614846	23614846	+	Silent	SNP	C	C	T	rs45439097	byFrequency	TCGA-55-8096-01A-11D-2238-08	TCGA-55-8096-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	babd96af-bc23-49ee-b8ef-541bc076c7c4	fbc4dd00-fd9b-4988-aa44-ce1598a2150b	g.chr16:23614846C>T	ENST00000261584.4	-	13	3647	c.3495G>A	c.(3493-3495)tcG>tcA	p.S1165S		NM_024675.3	NP_078951.2	Q86YC2	PALB2_HUMAN	partner and localizer of BRCA2	1165	Interaction with RAD51 and BRCA2.				double-strand break repair via homologous recombination	nucleoplasm	DNA binding|protein binding			breast(5)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(11)|lung(21)|ovary(3)|pancreas(1)|prostate(3)|skin(1)|stomach(1)|urinary_tract(3)	55				GBM - Glioblastoma multiforme(48;0.0167)		AGTCTGTACCCGACCATTTCA	0.413000			"""F, N, Mis"""			"""Wilms tumor, medulloblastoma, AML ,breast"""		Involved in tolerance or repair of DNA crosslinks					8	130					0	0	0.387290	0	0
TRAPPC8	22878	broad.mit.edu	37	18	29493475	29493475	+	Missense_Mutation	SNP	T	T	C			TCGA-55-8096-01A-11D-2238-08	TCGA-55-8096-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	babd96af-bc23-49ee-b8ef-541bc076c7c4	fbc4dd00-fd9b-4988-aa44-ce1598a2150b	g.chr18:29493475T>C	ENST00000283351.4	-	5	963	c.628A>G	c.(628-630)Att>Gtt	p.I210V	TRAPPC8_ENST00000582513.1_Missense_Mutation_p.I210V|TRAPPC8_ENST00000582539.1_Missense_Mutation_p.I156V	NM_014939.3	NP_055754.2	Q9Y2L5	TPPC8_HUMAN	trafficking protein particle complex 8	210					ER to Golgi vesicle-mediated transport	cis-Golgi network				breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(6)|large_intestine(7)|liver(2)|lung(13)|ovary(6)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	47						TCTTCATAAATTGATTCAGCT	0.313000													4	9					0	0	0.150653	0	0
CAPNS1	826	broad.mit.edu	37	19	36631958	36631958	+	Silent	SNP	C	C	G			TCGA-55-8096-01A-11D-2238-08	TCGA-55-8096-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	babd96af-bc23-49ee-b8ef-541bc076c7c4	fbc4dd00-fd9b-4988-aa44-ce1598a2150b	g.chr19:36631958C>G	ENST00000246533.3	+	2	643	c.45C>G	c.(43-45)ggC>ggG	p.G15G	CAPNS1_ENST00000588780.1_Silent_p.G15G|CAPNS1_ENST00000589146.1_Silent_p.G15G|CAPNS1_ENST00000587718.1_Silent_p.G15G|CAPNS1_ENST00000588815.1_Silent_p.G15G|CAPNS1_ENST00000590874.1_Silent_p.G15G	NM_001003962.1|NM_001749.2	NP_001003962.1|NP_001740.1	P04632	CPNS1_HUMAN	calpain, small subunit 1	15	Gly-rich (hydrophobic).|Poly-Gly.				positive regulation of cell proliferation	cytoplasm|plasma membrane	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity			cervix(1)|large_intestine(1)|lung(2)|upper_aerodigestive_tract(1)	5	Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.06)			gcggcggcggcgggggaggcg	0.736000													3	34					0	0	0.115264	0	0
KANK2	25959	broad.mit.edu	37	19	11303852	11303852	+	Nonsense_Mutation	SNP	C	C	A			TCGA-55-8096-01A-11D-2238-08	TCGA-55-8096-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	babd96af-bc23-49ee-b8ef-541bc076c7c4	fbc4dd00-fd9b-4988-aa44-ce1598a2150b	g.chr19:11303852C>A	ENST00000432929.2	-	4	1264	c.904G>T	c.(904-906)Gag>Tag	p.E302*	KANK2_ENST00000355150.5_Nonsense_Mutation_p.E302*|KANK2_ENST00000589894.1_Nonsense_Mutation_p.E302*|KANK2_ENST00000589359.1_Nonsense_Mutation_p.E302*|KANK2_ENST00000586659.1_Nonsense_Mutation_p.E302*	NM_001136191.2	NP_001129663.1	Q63ZY3	KANK2_HUMAN	KN motif and ankyrin repeat domains 2	302										endometrium(2)|large_intestine(1)|lung(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	14						GCCTGCAGCTCCTGCAGCGCC	0.697000													8	38					4.68919e-08	5.8135e-08	0.361761	1	0
NUP210L	91181	broad.mit.edu	37	1	154098868	154098868	+	Nonsense_Mutation	SNP	G	G	T			TCGA-55-8096-01A-11D-2238-08	TCGA-55-8096-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	babd96af-bc23-49ee-b8ef-541bc076c7c4	fbc4dd00-fd9b-4988-aa44-ce1598a2150b	g.chr1:154098868G>T	ENST00000368559.3	-	10	1328	c.1257C>A	c.(1255-1257)taC>taA	p.Y419*	NUP210L_ENST00000271854.3_Nonsense_Mutation_p.Y419*	NM_207308.2	NP_997191.2	Q5VU65	P210L_HUMAN	nucleoporin 210kDa-like	419						integral to membrane				NS(1)|breast(6)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(12)|lung(34)|ovary(4)|pancreas(1)|prostate(2)|skin(6)|urinary_tract(2)	80	all_lung(78;9.35e-31)|Lung NSC(65;1.33e-28)|Hepatocellular(266;0.0877)|Melanoma(130;0.128)		LUSC - Lung squamous cell carcinoma(543;0.151)|Colorectal(543;0.198)			TTACTATATGGTAAGATCCAT	0.393000													8	103					9.70103e-10	1.24643e-09	0.361761	1	0
RASGRF1	5923	broad.mit.edu	37	15	79327546	79327546	+	Silent	SNP	G	G	T			TCGA-55-8096-01A-11D-2238-08	TCGA-55-8096-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	babd96af-bc23-49ee-b8ef-541bc076c7c4	fbc4dd00-fd9b-4988-aa44-ce1598a2150b	g.chr15:79327546G>T	ENST00000419573.3	-	6	1159	c.885C>A	c.(883-885)acC>acA	p.T295T	RASGRF1_ENST00000560334.1_5'UTR|RASGRF1_ENST00000558480.2_Silent_p.T295T	NM_002891.4	NP_002882.3	Q13972	RGRF1_HUMAN	Ras protein-specific guanine nucleotide-releasing factor 1	295	DH.				activation of Rac GTPase activity|apoptosis|induction of apoptosis by extracellular signals|long-term memory|nerve growth factor receptor signaling pathway|neuron projection development|regulation of Rac protein signal transduction|small GTPase mediated signal transduction|synaptic transmission	cytosol|growth cone|plasma membrane|synaptosome	Rho guanyl-nucleotide exchange factor activity			breast(2)|central_nervous_system(2)|endometrium(7)|kidney(4)|large_intestine(18)|lung(23)|ovary(2)|prostate(6)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	71						AAAACATGATGGTTTCGCTGA	0.582000													5	27					3.59834e-05	4.26172e-05	0.217242	1	0
PEG3	5178	broad.mit.edu	37	19	57335025	57335025	+	Silent	SNP	G	G	T			TCGA-55-8096-01A-11D-2238-08	TCGA-55-8096-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	babd96af-bc23-49ee-b8ef-541bc076c7c4	fbc4dd00-fd9b-4988-aa44-ce1598a2150b	g.chr19:57335025G>T	ENST00000326441.9	-	5	780	c.417C>A	c.(415-417)acC>acA	p.T139T	ZIM2_ENST00000593711.1_Silent_p.T13T|ZIM2_ENST00000221722.5_Silent_p.T13T|ZIM2_ENST00000391708.3_Silent_p.T13T|ZIM2_ENST00000593931.1_Silent_p.T13T|PEG3_ENST00000423103.2_Silent_p.T139T|ZIM2_ENST00000601070.1_Silent_p.T13T|PEG3_ENST00000598410.1_Silent_p.T13T|ZIM2_ENST00000599935.1_Silent_p.T13T|PEG3_ENST00000593695.1_Silent_p.T13T	NM_006210.2	NP_006201.1	Q9GZU2	PEG3_HUMAN	paternally expressed 3	139					apoptosis|viral reproduction	cytoplasm|nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|biliary_tract(4)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(27)|lung(84)|ovary(8)|pancreas(5)|prostate(6)|skin(8)|stomach(2)|upper_aerodigestive_tract(6)	170		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0269)		CGTCGTCGCTGGTCACGTCAC	0.552000													24	104					9.80776e-20	1.55168e-19	0.706142	1	0
MYOM2	9172	broad.mit.edu	37	8	2044089	2044089	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8096-01A-11D-2238-08	TCGA-55-8096-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	babd96af-bc23-49ee-b8ef-541bc076c7c4	fbc4dd00-fd9b-4988-aa44-ce1598a2150b	g.chr8:2044089G>A	ENST00000262113.4	+	18	2269	c.2128G>A	c.(2128-2130)Gtc>Atc	p.V710I	MYOM2_ENST00000523438.1_Missense_Mutation_p.V135I	NM_003970.2	NP_003961.2	P54296	MYOM2_HUMAN	myomesin 2	710					muscle contraction	myosin filament	structural constituent of muscle			autonomic_ganglia(2)|breast(4)|central_nervous_system(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(11)|kidney(2)|large_intestine(17)|lung(39)|ovary(5)|prostate(1)|skin(10)|upper_aerodigestive_tract(3)	104		Ovarian(12;0.0572)|Colorectal(14;0.0844)|Hepatocellular(245;0.217)		BRCA - Breast invasive adenocarcinoma(11;1.85e-05)|Colorectal(4;0.0101)|READ - Rectum adenocarcinoma(4;0.148)|COAD - Colon adenocarcinoma(4;0.179)		CCTTGCAGCCGTCCCGTCCCA	0.617000													23	214					0	0	0.654019	0	0
EGFR	1956	broad.mit.edu	37	7	55259515	55259515	+	Missense_Mutation	SNP	T	T	G	rs121434568		TCGA-55-8096-01A-11D-2238-08	TCGA-55-8096-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	babd96af-bc23-49ee-b8ef-541bc076c7c4	fbc4dd00-fd9b-4988-aa44-ce1598a2150b	g.chr7:55259515T>G	ENST00000275493.2	+	21	2750	c.2573T>G	c.(2572-2574)cTg>cGg	p.L858R	EGFR_ENST00000455089.1_Missense_Mutation_p.L813R|EGFR_ENST00000454757.2_Missense_Mutation_p.L805R|EGFR_ENST00000442591.1_Intron	NM_005228.3	NP_005219.2	P00533	EGFR_HUMAN	epidermal growth factor receptor	858	Protein kinase.		L -> M (found in a lung cancer sample).|L -> R (found in a lung cancer sample; somatic mutation; constitutively activated enzyme with strongly increased kinase activity).		activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.L858R(1489)|p.L858Q(1)|p.L858K(1)		NS(2)|adrenal_gland(5)|biliary_tract(8)|bone(3)|breast(18)|central_nervous_system(106)|endometrium(26)|eye(3)|haematopoietic_and_lymphoid_tissue(9)|kidney(11)|large_intestine(85)|liver(2)|lung(13575)|oesophagus(21)|ovary(38)|pancreas(3)|peritoneum(11)|pleura(2)|prostate(35)|salivary_gland(11)|skin(9)|small_intestine(1)|soft_tissue(4)|stomach(41)|thymus(2)|thyroid(14)|upper_aerodigestive_tract(59)|urinary_tract(6)	14110	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	GATTTTGGGCTGGCCAAACTG	0.537000	L858R(NCIH1975_LUNG)	8	"""A, O, Mis"""		"""glioma, NSCLC"""	NSCLC			Lung Cancer, Familial Clustering of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			166	192					0	0	0.870114	0	0
EFNB1	1947	broad.mit.edu	37	X	68060199	68060199	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8096-01A-11D-2238-08	TCGA-55-8096-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	babd96af-bc23-49ee-b8ef-541bc076c7c4	fbc4dd00-fd9b-4988-aa44-ce1598a2150b	g.chrX:68060199G>T	ENST00000204961.4	+	5	1523	c.743G>T	c.(742-744)tGc>tTc	p.C248F		NM_004429.4	NP_004420.1	P98172	EFNB1_HUMAN	ephrin-B1	248					cell adhesion|cell-cell signaling	integral to plasma membrane|soluble fraction|synapse	ephrin receptor binding			breast(1)|endometrium(7)|kidney(1)|large_intestine(3)|lung(9)|ovary(1)	22						GGTGCCGGTTGCGTCATCTTC	0.612000													5	54					3.59834e-05	4.26172e-05	0.217242	1	0
TMLHE	55217	broad.mit.edu	37	X	154743762	154743762	+	Nonsense_Mutation	SNP	C	C	A			TCGA-55-8096-01A-11D-2238-08	TCGA-55-8096-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	babd96af-bc23-49ee-b8ef-541bc076c7c4	fbc4dd00-fd9b-4988-aa44-ce1598a2150b	g.chrX:154743762C>A	ENST00000334398.3	-	4	668	c.523G>T	c.(523-525)Gag>Tag	p.E175*	TMLHE_ENST00000369439.4_Nonsense_Mutation_p.E175*|TMLHE-AS1_ENST00000452506.1_RNA	NM_018196.3	NP_060666.1	Q9NVH6	TMLH_HUMAN	trimethyllysine hydroxylase, epsilon	175					carnitine biosynthetic process	mitochondrial matrix	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|trimethyllysine dioxygenase activity			breast(1)|endometrium(5)|kidney(2)|large_intestine(4)|lung(6)|ovary(1)|upper_aerodigestive_tract(1)	20	all_cancers(53;1.86e-17)|all_epithelial(53;2.71e-11)|all_lung(58;1.84e-07)|Lung NSC(58;5.62e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)				Succinic acid(DB00139)|Vitamin C(DB00126)	TTCAGTCCCTCGTTGGTTTCT	0.438000													8	130					4.68919e-08	5.8135e-08	0.361761	1	0
PCDHA13	56136	broad.mit.edu	37	5	140262054	140262054	+	Silent	SNP	G	G	A			TCGA-55-8096-01A-11D-2238-08	TCGA-55-8096-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	babd96af-bc23-49ee-b8ef-541bc076c7c4	fbc4dd00-fd9b-4988-aa44-ce1598a2150b	g.chr5:140262054G>A	ENST00000289272.2	+	1	201	c.201G>A	c.(199-201)gcG>gcA	p.A67A	PCDHA7_ENST00000525929.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA10_ENST00000307360.5_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA11_ENST00000398640.2_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA12_ENST00000398631.2_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA13_ENST00000409494.1_Silent_p.A67A|PCDHA10_ENST00000506939.2_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA5_ENST00000529619.1_Intron	NM_018904.2|NM_031865.1	NP_061727.1|NP_114071.1														NS(1)|biliary_tract(2)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(7)|kidney(2)|large_intestine(18)|liver(3)|lung(23)|ovary(4)|prostate(6)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(2)	95			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCCGGGTGGCGTCCAAAAGAC	0.632000													57	184					0	0	0.870114	0	0
MTDH	92140	broad.mit.edu	37	8	98718868	98718868	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8096-01A-11D-2238-08	TCGA-55-8096-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	babd96af-bc23-49ee-b8ef-541bc076c7c4	fbc4dd00-fd9b-4988-aa44-ce1598a2150b	g.chr8:98718868G>T	ENST00000336273.3	+	8	1490	c.1162G>T	c.(1162-1164)Gct>Tct	p.A388S	MTDH_ENST00000519934.1_Missense_Mutation_p.A332S	NM_178812.3	NP_848927.2	Q86UE4	LYRIC_HUMAN	metadherin	388	Lung-homing for mammary tumors (By similarity).				lipopolysaccharide-mediated signaling pathway|negative regulation of apoptosis|negative regulation of transcription from RNA polymerase II promoter|positive regulation of angiogenesis|positive regulation of autophagy|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of protein kinase B signaling cascade	apical plasma membrane|endoplasmic reticulum membrane|integral to membrane|intercellular canaliculus|nuclear body|nuclear membrane|nucleolus|perinuclear region of cytoplasm|tight junction	NF-kappaB binding|RNA polymerase II transcription factor binding|transcription coactivator activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(6)|large_intestine(5)|liver(1)|lung(8)|ovary(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	32	Breast(36;2.56e-06)		OV - Ovarian serous cystadenocarcinoma(57;0.178)			TCTGTCTTCTGCTGATCCCAA	0.388000													26	132					6.38683e-12	8.67954e-12	0.729181	1	0
TOP2A	7153	broad.mit.edu	37	17	38548934	38548934	+	Missense_Mutation	SNP	C	C	G			TCGA-55-8096-01A-11D-2238-08	TCGA-55-8096-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	babd96af-bc23-49ee-b8ef-541bc076c7c4	fbc4dd00-fd9b-4988-aa44-ce1598a2150b	g.chr17:38548934C>G	ENST00000423485.1	-	30	4025	c.3867G>C	c.(3865-3867)aaG>aaC	p.K1289N		NM_001067.3	NP_001058.2	P11388	TOP2A_HUMAN	topoisomerase (DNA) II alpha 170kDa	1289					apoptotic chromosome condensation|DNA ligation|DNA repair|DNA topological change|DNA-dependent DNA replication|mitotic cell cycle G2/M transition decatenation checkpoint|mitotic recombination|phosphatidylinositol-mediated signaling|positive regulation of apoptosis|positive regulation of retroviral genome replication|resolution of meiotic recombination intermediates|sister chromatid segregation	cytoplasm|DNA topoisomerase complex (ATP-hydrolyzing)|nucleolus|nucleoplasm|synaptonemal complex	ATP binding|chromatin binding|DNA topoisomerase (ATP-hydrolyzing) activity|DNA-dependent ATPase activity|drug binding|histone deacetylase binding|protein C-terminus binding|protein heterodimerization activity|protein homodimerization activity|protein kinase C binding|sequence-specific DNA binding transcription factor activity|ubiquitin binding	p.K1289N(1)		breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(8)|lung(9)|ovary(5)|pancreas(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)	39		Breast(137;0.00328)	STAD - Stomach adenocarcinoma(5;0.00183)		Amsacrine(DB00276)|Ciprofloxacin(DB00537)|Dexrazoxane(DB00380)|Doxorubicin(DB00997)|Enoxacin(DB00467)|Epirubicin(DB00445)|Etoposide(DB00773)|Fleroxacin(DB04576)|Gatifloxacin(DB01044)|Idarubicin(DB01177)|Levofloxacin(DB01137)|Lomefloxacin(DB00978)|Lucanthone(DB04967)|Mitoxantrone(DB01204)|Moxifloxacin(DB00218)|Norfloxacin(DB01059)|Ofloxacin(DB01165)|Pefloxacin(DB00487)|Podofilox(DB01179)|Sparfloxacin(DB01208)|Teniposide(DB00444)|Trovafloxacin(DB00685)|Valrubicin(DB00385)	GATTTCTCTTCTTTCCTTTTT	0.398000													21	112					0	0	0.608945	0	0
SLC37A2	219855	broad.mit.edu	37	11	124947410	124947410	+	Silent	SNP	C	C	T			TCGA-55-8096-01A-11D-2238-08	TCGA-55-8096-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	babd96af-bc23-49ee-b8ef-541bc076c7c4	fbc4dd00-fd9b-4988-aa44-ce1598a2150b	g.chr11:124947410C>T	ENST00000403796.2	+	4	601	c.300C>T	c.(298-300)atC>atT	p.I100I	SLC37A2_ENST00000407458.1_Silent_p.I100I|SLC37A2_ENST00000308074.4_Silent_p.I100I|SLC37A2_ENST00000298280.5_Silent_p.I100I	NM_001145290.1	NP_001138762.1	Q8TED4	SPX2_HUMAN	solute carrier family 37 (glucose-6-phosphate transporter), member 2	100					carbohydrate transport|transmembrane transport	integral to membrane				NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(6)|ovary(2)|prostate(2)|skin(1)|stomach(2)|urinary_tract(1)	27	all_hematologic(175;0.215)	Breast(109;0.012)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.152)|all_lung(97;0.159)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.61e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0384)		CCTATGCCATCGGCATGTTCA	0.532000													3	38					0	0	0.115264	0	0
HNRNPA3	220988	broad.mit.edu	37	2	178081321	178081321	+	Splice_Site	SNP	G	G	T			TCGA-55-8096-01A-11D-2238-08	TCGA-55-8096-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	babd96af-bc23-49ee-b8ef-541bc076c7c4	fbc4dd00-fd9b-4988-aa44-ce1598a2150b	g.chr2:178081321G>T	ENST00000411529.2	+	5	628		c.e5+1		HNRNPA3_ENST00000392524.2_Splice_Site|HNRNPA3_ENST00000435711.1_Splice_Site	NM_194247.2	NP_919223.1	P51991	ROA3_HUMAN	heterogeneous nuclear ribonucleoprotein A3							catalytic step 2 spliceosome|nucleolus|nucleoplasm	nucleotide binding|protein binding|RNA binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(3)|ovary(2)|urinary_tract(1)	16						TCACAGAGAGGTGAGTAGGAC	0.398000													8	123					6.40141e-05	7.49779e-05	0.387290	1	0
ANO5	203859	broad.mit.edu	37	11	22291917	22291917	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8096-01A-11D-2238-08	TCGA-55-8096-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	babd96af-bc23-49ee-b8ef-541bc076c7c4	fbc4dd00-fd9b-4988-aa44-ce1598a2150b	g.chr11:22291917G>A	ENST00000324559.8	+	18	2275	c.1958G>A	c.(1957-1959)aGt>aAt	p.S653N		NM_001142649.1|NM_213599.2	NP_001136121.1|NP_998764.1	Q75V66	ANO5_HUMAN	anoctamin 5	653						chloride channel complex|endoplasmic reticulum membrane	chloride channel activity			breast(2)|central_nervous_system(3)|endometrium(1)|kidney(2)|large_intestine(12)|lung(36)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	63						AAGCTGTATAGTCGATGGGAG	0.398000													13	89					0	0	0.500413	0	0
ZNF432	9668	broad.mit.edu	37	19	52538153	52538153	+	Missense_Mutation	SNP	G	G	C			TCGA-55-8096-01A-11D-2238-08	TCGA-55-8096-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	babd96af-bc23-49ee-b8ef-541bc076c7c4	fbc4dd00-fd9b-4988-aa44-ce1598a2150b	g.chr19:52538153G>C	ENST00000594154.1	-	5	991	c.779C>G	c.(778-780)tCt>tGt	p.S260C	ZNF432_ENST00000221315.5_Missense_Mutation_p.S260C			O94892	ZN432_HUMAN	zinc finger protein 432	260					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.S260Y(1)		breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|liver(1)|lung(5)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	29		all_neural(266;0.117)		GBM - Glioblastoma multiforme(134;0.0054)|OV - Ovarian serous cystadenocarcinoma(262;0.0182)		GCATATAAAAGATTTCTCTCT	0.373000													5	82					0	0	0.184627	0	0
RBMXL1	494115	broad.mit.edu	37	1	89448433	89448433	+	Silent	SNP	T	T	A			TCGA-55-8096-01A-11D-2238-08	TCGA-55-8096-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	babd96af-bc23-49ee-b8ef-541bc076c7c4	fbc4dd00-fd9b-4988-aa44-ce1598a2150b	g.chr1:89448433T>A	ENST00000399794.2	-	3	1792	c.1077A>T	c.(1075-1077)tcA>tcT	p.S359S	RBMXL1_ENST00000321792.5_Silent_p.S359S|CCBL2_ENST00000370491.3_Intron|CCBL2_ENST00000370485.2_Intron|CCBL2_ENST00000446900.2_Intron|CCBL2_ENST00000260508.4_Intron	NM_001162536.2	NP_001156008.1	Q96E39	RBMXL_HUMAN	RNA binding motif protein, X-linked-like 1	359	Ser-rich.						nucleotide binding|RNA binding										AGGAATCACGTGAAGAAGGGT	0.537000													34	109					0	0	0.779181	0	0
SLC15A4	121260	broad.mit.edu	37	12	129293374	129293374	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8096-01A-11D-2238-08	TCGA-55-8096-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	babd96af-bc23-49ee-b8ef-541bc076c7c4	fbc4dd00-fd9b-4988-aa44-ce1598a2150b	g.chr12:129293374G>A	ENST00000266771.5	-	5	1256	c.1217C>T	c.(1216-1218)gCc>gTc	p.A406V	SLC15A4_ENST00000544112.1_Missense_Mutation_p.A69V	NM_145648.3	NP_663623.1	Q8N697	S15A4_HUMAN	solute carrier family 15 (oligopeptide transporter), member 4	406					oligopeptide transport|protein transport	integral to membrane|lysosomal membrane	peptide:hydrogen symporter activity			endometrium(4)|kidney(2)|large_intestine(4)|lung(11)|skin(1)	22	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.69e-06)|Epithelial(86;1.17e-05)|all cancers(50;5.07e-05)		CATGCCCACGGCGATCCTCTT	0.552000													15	70					0	0	0.500413	0	0
LOC101927209	101927209	broad.mit.edu	37	1	142713774	142713774	+	RNA	SNP	A	A	G			TCGA-55-8096-01A-11D-2238-08	TCGA-55-8096-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	babd96af-bc23-49ee-b8ef-541bc076c7c4	fbc4dd00-fd9b-4988-aa44-ce1598a2150b	g.chr1:142713774A>G	ENST00000369381.2	-	0	831																											CTTTTTCCACATTGTCATTTT	0.284000													3	62					0	0	0.115264	0	0
CREB5	9586	broad.mit.edu	37	7	28848987	28848987	+	Nonsense_Mutation	SNP	G	G	T			TCGA-55-8096-01A-11D-2238-08	TCGA-55-8096-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	babd96af-bc23-49ee-b8ef-541bc076c7c4	fbc4dd00-fd9b-4988-aa44-ce1598a2150b	g.chr7:28848987G>T	ENST00000357727.2	+	9	1600	c.1210G>T	c.(1210-1212)Gaa>Taa	p.E404*	CREB5_ENST00000396298.2_Nonsense_Mutation_p.E265*|CREB5_ENST00000396299.2_Nonsense_Mutation_p.E371*|CREB5_ENST00000409603.1_Nonsense_Mutation_p.E371*|CREB5_ENST00000396300.2_Nonsense_Mutation_p.E397*	NM_182898.2	NP_878901.2	Q02930	CREB5_HUMAN	cAMP responsive element binding protein 5	404	Leucine-zipper.				positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter		protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(2)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(7)|liver(1)|lung(13)|prostate(1)|skin(3)	32						GATGTCATTGGAAAAGAAAGC	0.577000													33	88					4.4194e-11	5.81934e-11	0.769981	1	0
ACSM5	54988	broad.mit.edu	37	16	20432607	20432607	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8096-01A-11D-2238-08	TCGA-55-8096-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	babd96af-bc23-49ee-b8ef-541bc076c7c4	fbc4dd00-fd9b-4988-aa44-ce1598a2150b	g.chr16:20432607G>A	ENST00000331849.4	+	5	798	c.651G>A	c.(649-651)atG>atA	p.M217I		NM_017888.2	NP_060358.2	Q6NUN0	ACSM5_HUMAN	acyl-CoA synthetase medium-chain family member 5	217			M -> V (in dbSNP:rs59025904).		fatty acid metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|GTP binding|metal ion binding			breast(1)|endometrium(6)|kidney(2)|large_intestine(6)|lung(28)|ovary(3)|prostate(1)|skin(3)|urinary_tract(1)	51						ACAACTGCATGAGGACAAAGA	0.512000													7	104					0	0	0.387290	0	0
ACP5	54	broad.mit.edu	37	19	11687316	11687316	+	Silent	SNP	T	T	A	rs147105591		TCGA-55-8096-01A-11D-2238-08	TCGA-55-8096-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	babd96af-bc23-49ee-b8ef-541bc076c7c4	fbc4dd00-fd9b-4988-aa44-ce1598a2150b	g.chr19:11687316T>A	ENST00000592828.1	-	6	879	c.477A>T	c.(475-477)acA>acT	p.T159T	ACP5_ENST00000590420.1_Intron|ACP5_ENST00000412435.2_Silent_p.T159T|ACP5_ENST00000218758.5_Silent_p.T159T|ACP5_ENST00000433365.2_Silent_p.T159T	NM_001111034.1	NP_001104504.1	P13686	PPA5_HUMAN	acid phosphatase 5, tartrate resistant	159					water-soluble vitamin metabolic process	cytosol|integral to membrane|lysosome	acid phosphatase activity|ferric iron binding|ferrous iron binding			breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(1)|lung(4)|pancreas(1)	9						TGCCACATAGTGTCACTGTGT	0.562000													7	65					0	0	0.278610	0	0
NFASC	23114	broad.mit.edu	37	1	204985460	204985460	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8096-01A-11D-2238-08	TCGA-55-8096-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	babd96af-bc23-49ee-b8ef-541bc076c7c4	fbc4dd00-fd9b-4988-aa44-ce1598a2150b	g.chr1:204985460G>T	ENST00000367172.4	+	32	4165	c.3837G>T	c.(3835-3837)caG>caT	p.Q1279H	NFASC_ENST00000360049.4_Missense_Mutation_p.Q1101H|NFASC_ENST00000367170.4_Missense_Mutation_p.Q1200H|NFASC_ENST00000338515.6_Missense_Mutation_p.Q1189H|NFASC_ENST00000367169.4_Missense_Mutation_p.Q1003H|NFASC_ENST00000404076.1_Missense_Mutation_p.Q1089H|NFASC_ENST00000401399.1_Missense_Mutation_p.Q1172H|NFASC_ENST00000404907.1_Missense_Mutation_p.Q1106H|NFASC_ENST00000539706.1_Missense_Mutation_p.Q1106H|NFASC_ENST00000339876.6_Missense_Mutation_p.Q1172H|NFASC_ENST00000495396.1_3'UTR|NFASC_ENST00000513543.1_Missense_Mutation_p.Q1101H|NFASC_ENST00000367171.4_Missense_Mutation_p.Q1264H|NFASC_ENST00000338586.6_Missense_Mutation_p.Q1156H			O94856	NFASC_HUMAN	neurofascin	1279					axon guidance|cell adhesion|myelination|peripheral nervous system development	integral to membrane|node of Ranvier|plasma membrane	protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|liver(1)|lung(24)|ovary(3)|pancreas(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)	81	all_cancers(21;0.0375)|Breast(84;0.0437)|all_epithelial(62;0.171)|Prostate(682;0.19)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.158)			AGCCCCTGCAGGGCAGTCAGA	0.592000													22	342					1.2476e-16	1.86261e-16	0.706142	1	0
PRDM8	56978	broad.mit.edu	37	4	81123265	81123265	+	Missense_Mutation	SNP	C	C	G			TCGA-55-8096-01A-11D-2238-08	TCGA-55-8096-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	babd96af-bc23-49ee-b8ef-541bc076c7c4	fbc4dd00-fd9b-4988-aa44-ce1598a2150b	g.chr4:81123265C>G	ENST00000339711.4	+	10	1880	c.649C>G	c.(649-651)Cag>Gag	p.Q217E	PRDM8_ENST00000415738.2_Missense_Mutation_p.Q217E|PRDM8_ENST00000504452.1_Missense_Mutation_p.Q217E	NM_020226.3	NP_064611.3	Q9NQV8	PRDM8_HUMAN	PR domain containing 8	217	Gly-rich.|Poly-Gln.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(2)|skin(2)	10						gcagcagcagcagGAGGCACC	0.672000											OREG0016246	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	3	35					0	0	0.115264	0	0
WHAMMP2	440253	broad.mit.edu	37	15	28999701	28999701	+	RNA	SNP	G	G	T			TCGA-55-8096-01A-11D-2238-08	TCGA-55-8096-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	babd96af-bc23-49ee-b8ef-541bc076c7c4	fbc4dd00-fd9b-4988-aa44-ce1598a2150b	g.chr15:28999701G>T	ENST00000512149.2	+	0	379					NR_026589.1																						GTATTCAGATGGTGAGTGTCC	0.463000													5	32					0.184627	0.187277	0.184627	1	0
KIAA1033	23325	broad.mit.edu	37	12	105538175	105538175	+	Silent	SNP	G	G	T			TCGA-55-8096-01A-11D-2238-08	TCGA-55-8096-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	babd96af-bc23-49ee-b8ef-541bc076c7c4	fbc4dd00-fd9b-4988-aa44-ce1598a2150b	g.chr12:105538175G>T	ENST00000332180.5	+	21	2208	c.2121G>T	c.(2119-2121)ctG>ctT	p.L707L		NM_015275.1	NP_056090.1	Q2M389	WAHS7_HUMAN	KIAA1033	707					endosome transport	WASH complex				breast(3)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(8)|lung(15)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	41						TGAAAGACCTGGCTCTTTTTT	0.373000													7	97					0.000673444	0.000755398	0.361761	1	0
MARCH1	55016	broad.mit.edu	37	4	164449968	164449968	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8096-01A-11D-2238-08	TCGA-55-8096-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	babd96af-bc23-49ee-b8ef-541bc076c7c4	fbc4dd00-fd9b-4988-aa44-ce1598a2150b	g.chr4:164449968C>A	ENST00000503008.1	-	8	1778	c.802G>T	c.(802-804)Gta>Tta	p.V268L	MARCH1_ENST00000339875.5_Missense_Mutation_p.V251L|MARCH1_ENST00000514618.1_Missense_Mutation_p.V524L|MARCH1_ENST00000274056.7_Missense_Mutation_p.V268L	NM_001166373.1	NP_001159845.1	Q8TCQ1	MARH1_HUMAN	membrane-associated ring finger (C3HC4) 1, E3 ubiquitin protein ligase	268	Responsible for down-regulation of CD86 and MHC class II cell surface expression (By similarity).				antigen processing and presentation of peptide antigen via MHC class II|immune response	cytoplasmic vesicle membrane|early endosome membrane|Golgi apparatus|integral to membrane|late endosome membrane|lysosomal membrane|plasma membrane	MHC protein binding|ubiquitin-protein ligase activity|zinc ion binding			endometrium(2)|kidney(3)|large_intestine(3)|lung(20)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	36	all_hematologic(180;0.166)	Prostate(90;0.0959)|all_neural(102;0.223)				GTTTGTGGTACAGGCACTACC	0.453000													5	65					0.184627	0.187277	0.184627	1	0
SLITRK5	26050	broad.mit.edu	37	13	88329425	88329425	+	Silent	SNP	G	G	A			TCGA-55-8096-01A-11D-2238-08	TCGA-55-8096-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	babd96af-bc23-49ee-b8ef-541bc076c7c4	fbc4dd00-fd9b-4988-aa44-ce1598a2150b	g.chr13:88329425G>A	ENST00000325089.6	+	2	2001	c.1782G>A	c.(1780-1782)gcG>gcA	p.A594A	SLITRK5_ENST00000400028.3_Silent_p.A353A	NM_015567.1	NP_056382.1	O94991	SLIK5_HUMAN	SLIT and NTRK-like family, member 5	594	LRRCT 2.					integral to membrane		p.A594A(1)		breast(1)|central_nervous_system(2)|endometrium(6)|kidney(6)|large_intestine(14)|lung(40)|ovary(2)|pancreas(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(4)	81	all_neural(89;0.101)|Medulloblastoma(90;0.163)					TCTGTAAGGCGCCCAAAAAAT	0.527000													18	210					0	0	0.557998	0	0
AXDND1	126859	broad.mit.edu	37	1	179363129	179363129	+	Missense_Mutation	SNP	A	A	C			TCGA-55-8096-01A-11D-2238-08	TCGA-55-8096-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	babd96af-bc23-49ee-b8ef-541bc076c7c4	fbc4dd00-fd9b-4988-aa44-ce1598a2150b	g.chr1:179363129A>C	ENST00000367618.3	+	10	1342	c.955A>C	c.(955-957)Att>Ctt	p.I319L	AXDND1_ENST00000457238.2_Missense_Mutation_p.I319L|AXDND1_ENST00000461179.2_3'UTR	NM_144696.4	NP_653297.3	Q5T1B0	AXDN1_HUMAN	axonemal dynein light chain domain containing 1	319										NS(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(27)|ovary(1)|pancreas(1)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)	59						GGACCAGCGCATTTTAGAAGA	0.383000													23	132					0	0	0.729181	0	0
GTF3C3	9330	broad.mit.edu	37	2	197657782	197657782	+	Silent	SNP	C	C	T			TCGA-55-8096-01A-11D-2238-08	TCGA-55-8096-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	babd96af-bc23-49ee-b8ef-541bc076c7c4	fbc4dd00-fd9b-4988-aa44-ce1598a2150b	g.chr2:197657782C>T	ENST00000263956.3	-	3	398	c.309G>A	c.(307-309)gaG>gaA	p.E103E	GTF3C3_ENST00000409364.3_Silent_p.E103E	NM_012086.4	NP_036218.1	Q9Y5Q9	TF3C3_HUMAN	general transcription factor IIIC, polypeptide 3, 102kDa	103	Glu-rich.					transcription factor TFIIIC complex	DNA binding|protein binding	p.E103E(1)		breast(4)|endometrium(3)|kidney(1)|large_intestine(9)|lung(5)|ovary(3)|pancreas(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	33						cctcctcctcctcttcttcct	0.468000													4	36					0	0	0.150653	0	0
UBQLN4	56893	broad.mit.edu	37	1	156021524	156021524	+	Missense_Mutation	SNP	A	A	T			TCGA-55-8096-01A-11D-2238-08	TCGA-55-8096-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	babd96af-bc23-49ee-b8ef-541bc076c7c4	fbc4dd00-fd9b-4988-aa44-ce1598a2150b	g.chr1:156021524A>T	ENST00000368309.3	-	2	325	c.233T>A	c.(232-234)gTc>gAc	p.V78D	UBQLN4_ENST00000368307.1_Missense_Mutation_p.V78D|UBQLN4_ENST00000472638.1_5'UTR	NM_020131.3	NP_064516.2	Q9NRR5	UBQL4_HUMAN	ubiquilin 4	78	Ubiquitin-like.					cytosol|endoplasmic reticulum membrane|nucleus	identical protein binding			NS(1)|autonomic_ganglia(1)|breast(2)|cervix(1)|kidney(1)|large_intestine(1)|lung(6)|pancreas(1)|skin(2)	16	Hepatocellular(266;0.133)|all_neural(408;0.195)					GACCAGATGGACAGTGAGCCC	0.517000													21	94					0	0	0.654019	0	0
TIAM1	7074	broad.mit.edu	37	21	32639182	32639182	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8096-01A-11D-2238-08	TCGA-55-8096-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	babd96af-bc23-49ee-b8ef-541bc076c7c4	fbc4dd00-fd9b-4988-aa44-ce1598a2150b	g.chr21:32639182G>A	ENST00000286827.3	-	5	578	c.107C>T	c.(106-108)aCg>aTg	p.T36M	TIAM1_ENST00000541036.1_Missense_Mutation_p.T36M|TIAM1_ENST00000469412.1_Intron	NM_003253.2	NP_003244.2	Q13009	TIAM1_HUMAN	T-cell lymphoma invasion and metastasis 1	36					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cell-cell junction|cytosol	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			autonomic_ganglia(3)|breast(7)|central_nervous_system(2)|endometrium(13)|kidney(4)|large_intestine(33)|lung(44)|ovary(2)|prostate(3)|skin(2)|urinary_tract(2)	115						GGTCCTCCGCGTCTTGTGCGA	0.607000													9	46					0	0	0.335167	0	0
OR5D16	390144	broad.mit.edu	37	11	55606983	55606983	+	Silent	SNP	C	C	A			TCGA-55-8096-01A-11D-2238-08	TCGA-55-8096-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	babd96af-bc23-49ee-b8ef-541bc076c7c4	fbc4dd00-fd9b-4988-aa44-ce1598a2150b	g.chr11:55606983C>A	ENST00000378396.1	+	1	756	c.756C>A	c.(754-756)atC>atA	p.I252I		NM_001005496.1	NP_001005496.1	Q8NGK9	OR5DG_HUMAN	olfactory receptor, family 5, subfamily D, member 16	252					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|endometrium(2)|large_intestine(4)|lung(26)|ovary(5)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	44		all_epithelial(135;0.208)				CCATCACCATCTTCCATGGCA	0.522000													17	118					0.000132079	0.00015385	0.575678	1	0
TRIP6	7205	broad.mit.edu	37	7	100470331	100470331	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8096-01A-11D-2238-08	TCGA-55-8096-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	babd96af-bc23-49ee-b8ef-541bc076c7c4	fbc4dd00-fd9b-4988-aa44-ce1598a2150b	g.chr7:100470331G>T	ENST00000200457.4	+	8	1624	c.1264G>T	c.(1264-1266)Gat>Tat	p.D422Y		NM_003302.2	NP_003293.2	Q15654	TRIP6_HUMAN	thyroid hormone receptor interactor 6	422	LIM zinc-binding 3.				focal adhesion assembly|positive regulation of cell migration|regulation of transcription, DNA-dependent|release of cytoplasmic sequestered NF-kappaB|transcription, DNA-dependent	cytoplasm|cytoskeleton|focal adhesion|nucleus	identical protein binding|interleukin-1 receptor binding|kinase binding|thyroid hormone receptor binding|zinc ion binding			breast(1)|central_nervous_system(3)|endometrium(2)|large_intestine(2)|liver(1)|lung(5)	14	Lung NSC(181;0.041)|all_lung(186;0.0581)					TGTTGCTCTGGATCGAAGTTT	0.577000													17	65					7.45023e-12	1.00602e-11	0.592651	1	0
SPEF2	79925	broad.mit.edu	37	5	35759701	35759701	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8096-01A-11D-2238-08	TCGA-55-8096-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	babd96af-bc23-49ee-b8ef-541bc076c7c4	fbc4dd00-fd9b-4988-aa44-ce1598a2150b	g.chr5:35759701G>T	ENST00000440995.2	+	25	3485	c.3485G>T	c.(3484-3486)aGa>aTa	p.R1162I	SPEF2_ENST00000356031.3_Missense_Mutation_p.R1167I|CTD-2113L7.1_ENST00000510433.1_RNA			Q9C093	SPEF2_HUMAN	sperm flagellar 2	1167					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		ATP binding|nucleobase, nucleoside, nucleotide kinase activity|protein dimerization activity			breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(15)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	37	all_lung(31;7.56e-05)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			GATACAAAGAGACTCCTTCAA	0.373000													34	200					6.50621e-10	8.46207e-10	0.769981	1	0
KRTAP10-6	386674	broad.mit.edu	37	21	46011439	46011439	+	Silent	SNP	G	G	A			TCGA-55-8096-01A-11D-2238-08	TCGA-55-8096-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	babd96af-bc23-49ee-b8ef-541bc076c7c4	fbc4dd00-fd9b-4988-aa44-ce1598a2150b	g.chr21:46011439G>A	ENST00000400368.1	-	1	947	c.927C>T	c.(925-927)caC>caT	p.H309H	TSPEAR_ENST00000323084.4_Intron	NM_198688.2	NP_941961.2	P60371	KR106_HUMAN	keratin associated protein 10-6	309	29 X 5 AA repeats of C-C-X(3).					keratin filament				endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(6)|prostate(3)|skin(1)|stomach(1)|urinary_tract(1)	23						TGCACACAGGGTGGCAGAGGA	0.677000													64	202					0	0	0.870114	0	0
PTPRD	5789	broad.mit.edu	37	9	8486032	8486032	+	Missense_Mutation	SNP	C	C	G			TCGA-55-8096-01A-11D-2238-08	TCGA-55-8096-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	babd96af-bc23-49ee-b8ef-541bc076c7c4	fbc4dd00-fd9b-4988-aa44-ce1598a2150b	g.chr9:8486032C>G	ENST00000381196.4	-	25	3328	c.2785G>C	c.(2785-2787)Ggc>Cgc	p.G929R	PTPRD_ENST00000397611.3_Intron|PTPRD_ENST00000355233.5_Intron|PTPRD_ENST00000397617.3_Intron|PTPRD_ENST00000471274.1_5'UTR|PTPRD_ENST00000540109.1_Missense_Mutation_p.G929R|PTPRD_ENST00000360074.4_Missense_Mutation_p.G916R|PTPRD_ENST00000537002.1_Intron|PTPRD_ENST00000358503.5_Missense_Mutation_p.G907R|PTPRD_ENST00000397606.3_Intron|PTPRD_ENST00000486161.1_Intron|PTPRD_ENST00000356435.5_Missense_Mutation_p.G929R	NM_002839.3	NP_002830.1	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	929	Fibronectin type-III 7.				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(7)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|liver(1)|lung(83)|ovary(4)|pancreas(1)|prostate(7)|skin(19)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	168		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		GAAGTGGTGCCTTCTGAGTGA	0.468000										TSP Lung(15;0.13)			4	50					0	0	0.217242	0	0
ZMYND12	84217	broad.mit.edu	37	1	42905682	42905682	+	Missense_Mutation	SNP	C	C	T			TCGA-55-8096-01A-11D-2238-08	TCGA-55-8096-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	babd96af-bc23-49ee-b8ef-541bc076c7c4	fbc4dd00-fd9b-4988-aa44-ce1598a2150b	g.chr1:42905682C>T	ENST00000372565.3	-	4	708	c.439G>A	c.(439-441)Gtt>Att	p.V147I	ZMYND12_ENST00000433602.2_Missense_Mutation_p.V37I	NM_032257.4	NP_115633.3	Q9H0C1	ZMY12_HUMAN	zinc finger, MYND-type containing 12	147						intracellular	zinc ion binding			NS(1)|endometrium(2)|large_intestine(3)|lung(5)|ovary(2)|prostate(2)|skin(2)	17	Ovarian(52;0.00744)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				TCAGCCTGAACGATTCGGCCC	0.443000													23	72					0	0	0.667858	0	0
PPP6R2	9701	broad.mit.edu	37	22	50878172	50878172	+	Missense_Mutation	SNP	C	C	T	rs148549099		TCGA-55-8096-01A-11D-2238-08	TCGA-55-8096-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	babd96af-bc23-49ee-b8ef-541bc076c7c4	fbc4dd00-fd9b-4988-aa44-ce1598a2150b	g.chr22:50878172C>T	ENST00000359139.3	+	19	2487	c.2093C>T	c.(2092-2094)aCg>aTg	p.T698M	PPP6R2_ENST00000395744.3_Missense_Mutation_p.T697M|PPP6R2_ENST00000216061.5_Missense_Mutation_p.T724M|PPP6R2_ENST00000395741.3_Missense_Mutation_p.T698M	NM_001242898.1|NM_001242899.1|NM_001242900.1|NM_014678.4	NP_001229827.1|NP_001229828.1|NP_001229829.1|NP_055493.2	O75170	PP6R2_HUMAN	protein phosphatase 6, regulatory subunit 2	724						cytoplasm|intracellular membrane-bounded organelle	protein binding			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(2)|liver(1)|lung(6)|ovary(2)|skin(1)|urinary_tract(1)	22						GCGAACTCAACGCCCACAGCC	0.632000													7	34					0	0	0.278610	0	0
SLC7A5	8140	broad.mit.edu	37	16	87870252	87870252	+	Splice_Site	SNP	C	C	A			TCGA-55-8096-01A-11D-2238-08	TCGA-55-8096-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	babd96af-bc23-49ee-b8ef-541bc076c7c4	fbc4dd00-fd9b-4988-aa44-ce1598a2150b	g.chr16:87870252C>A	ENST00000261622.4	-	8	1207	c.1140_splice	c.e8-1	p.C381_splice	RP4-536B24.2_ENST00000563687.1_RNA|SLC7A5_ENST00000565644.1_Splice_Site_p.C115_splice	NM_003486.5	NP_003477.4	Q01650	LAT1_HUMAN	solute carrier family 7 (amino acid transporter light chain, L system), member 5	381					blood coagulation|cell differentiation|cellular amino acid metabolic process|ion transport|leukocyte migration|nervous system development	apical plasma membrane|cytosol|integral to membrane	neutral amino acid transmembrane transporter activity|peptide antigen binding			endometrium(3)|kidney(1)|large_intestine(1)|lung(4)|skin(1)	10				BRCA - Breast invasive adenocarcinoma(80;0.049)		CGTCATCACACACTGGAAGAG	0.642000													12	41					1.37285e-15	2.03528e-15	0.500413	1	0
MS4A10	341116	broad.mit.edu	37	11	60561459	60561459	+	Silent	SNP	G	G	T	rs59605421		TCGA-55-8096-01A-11D-2238-08	TCGA-55-8096-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	babd96af-bc23-49ee-b8ef-541bc076c7c4	fbc4dd00-fd9b-4988-aa44-ce1598a2150b	g.chr11:60561459G>T	ENST00000308287.1	+	5	471	c.375G>T	c.(373-375)ctG>ctT	p.L125L		NM_206893.3	NP_996776.2	Q96PG2	M4A10_HUMAN	membrane-spanning 4-domains, subfamily A, member 10	125						integral to membrane	receptor activity			endometrium(1)|kidney(1)|large_intestine(7)|lung(9)|ovary(1)|skin(2)	21						TGTTGTGCCTGATGACAAACC	0.507000													16	122					9.16793e-09	1.15691e-08	0.520397	1	0
PLCB1	23236	broad.mit.edu	37	20	8862309	8862309	+	Missense_Mutation	SNP	A	A	G			TCGA-55-8096-01A-11D-2238-08	TCGA-55-8096-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	babd96af-bc23-49ee-b8ef-541bc076c7c4	fbc4dd00-fd9b-4988-aa44-ce1598a2150b	g.chr20:8862309A>G	ENST00000338037.6	+	32	3491	c.3464A>G	c.(3463-3465)aAa>aGa	p.K1155R	PLCB1_ENST00000378641.3_3'UTR	NM_015192.2	NP_056007.1	Q9NQ66	PLCB1_HUMAN	phospholipase C, beta 1 (phosphoinositide-specific)	1155					activation of meiosis involved in egg activation|CD24 biosynthetic process|cerebral cortex development|G1 phase|G2/M transition of mitotic cell cycle|glutamate signaling pathway|insulin-like growth factor receptor signaling pathway|interleukin-1-mediated signaling pathway|interleukin-12-mediated signaling pathway|interleukin-15-mediated signaling pathway|intracellular signal transduction|lipid catabolic process|memory|muscarinic acetylcholine receptor signaling pathway|negative regulation of monocyte extravasation|negative regulation of transcription, DNA-dependent|phosphatidylinositol metabolic process|positive regulation of acrosome reaction|positive regulation of developmental growth|positive regulation of embryonic development|positive regulation of interleukin-12 production|positive regulation of JNK cascade|positive regulation of myoblast differentiation|positive regulation of transcription, DNA-dependent|regulation of fertilization|regulation of G-protein coupled receptor protein signaling pathway|synaptic transmission	cytosol|nuclear chromatin|nuclear speck	calcium ion binding|calmodulin binding|enzyme binding|GTPase activator activity|phosphatidylinositol phospholipase C activity|phosphatidylinositol-4,5-bisphosphate binding|protein homodimerization activity|signal transducer activity			NS(2)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(11)|liver(2)|lung(41)|ovary(4)|prostate(3)|skin(12)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(4)	95						GACAAATTCAAAAGACTGCCC	0.478000													85	146					0	0	0.870114	0	0
BOD1L1	259282	broad.mit.edu	37	4	13616371	13616371	+	Missense_Mutation	SNP	A	A	G			TCGA-55-8096-01A-11D-2238-08	TCGA-55-8096-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	babd96af-bc23-49ee-b8ef-541bc076c7c4	fbc4dd00-fd9b-4988-aa44-ce1598a2150b	g.chr4:13616371A>G	ENST00000040738.5	-	4	758	c.623T>C	c.(622-624)aTa>aCa	p.I208T		NM_148894.2	NP_683692.2	Q8NFC6	BOD1L_HUMAN	biorientation of chromosomes in cell division 1-like 1	208							DNA binding										AAGAGAAGTTATGGTTTCCAA	0.418000													6	27					0	0	0.307466	0	0
DCUN1D4	23142	broad.mit.edu	37	4	52779533	52779533	+	Silent	SNP	C	C	T			TCGA-55-8096-01A-11D-2238-08	TCGA-55-8096-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	babd96af-bc23-49ee-b8ef-541bc076c7c4	fbc4dd00-fd9b-4988-aa44-ce1598a2150b	g.chr4:52779533C>T	ENST00000334635.5	+	10	978	c.798C>T	c.(796-798)ctC>ctT	p.L266L	DCUN1D4_ENST00000381441.3_Silent_p.L231L|DCUN1D4_ENST00000451288.2_Silent_p.L310L|DCUN1D4_ENST00000381437.4_Silent_p.L206L	NM_001040402.1	NP_001035492.1	Q92564	DCNL4_HUMAN	DCN1, defective in cullin neddylation 1, domain containing 4	266	DCUN1.									endometrium(2)|large_intestine(2)|lung(2)|ovary(2)|skin(1)	9			GBM - Glioblastoma multiforme(4;1.93e-11)|LUSC - Lung squamous cell carcinoma(32;0.00654)			ATCTTGACCTCAGCAACTATG	0.388000													16	66					0	0	0.592651	0	0
HCN1	348980	broad.mit.edu	37	5	45267353	45267353	+	Missense_Mutation	SNP	T	T	C			TCGA-55-8096-01A-11D-2238-08	TCGA-55-8096-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	babd96af-bc23-49ee-b8ef-541bc076c7c4	fbc4dd00-fd9b-4988-aa44-ce1598a2150b	g.chr5:45267353T>C	ENST00000303230.4	-	7	1678	c.1621A>G	c.(1621-1623)Att>Gtt	p.I541V		NM_021072.3	NP_066550.2	O60741	HCN1_HUMAN	hyperpolarization activated cyclic nucleotide-gated potassium channel 1	541						integral to membrane	cAMP binding|sodium channel activity|voltage-gated potassium channel activity			NS(3)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(21)|liver(1)|lung(98)|ovary(1)|prostate(7)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(5)	156						AGCAGGCAAATCTCTATAAAA	0.398000													15	124					0	0	0.575678	0	0
BMP1	649	broad.mit.edu	37	8	22059403	22059403	+	Missense_Mutation	SNP	G	G	C			TCGA-55-8096-01A-11D-2238-08	TCGA-55-8096-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	babd96af-bc23-49ee-b8ef-541bc076c7c4	fbc4dd00-fd9b-4988-aa44-ce1598a2150b	g.chr8:22059403G>C	ENST00000306385.5	+	16	2865	c.2195G>C	c.(2194-2196)gGc>gCc	p.G732A	BMP1_ENST00000354870.5_3'UTR	NM_006129.4	NP_006120.1	P13497	BMP1_HUMAN	bone morphogenetic protein 1	732	EGF-like 2; calcium-binding (Potential).				cartilage condensation|cell differentiation|lipid metabolic process|lipoprotein metabolic process|ossification|positive regulation of cartilage development|proteolysis	extracellular space	calcium ion binding|cytokine activity|growth factor activity|metalloendopeptidase activity|zinc ion binding			breast(1)|endometrium(7)|kidney(2)|large_intestine(7)|lung(7)|ovary(2)|prostate(1)|skin(3)	30				Colorectal(74;0.00229)|COAD - Colon adenocarcinoma(73;0.0661)|READ - Rectum adenocarcinoma(644;0.11)		TGCCGCAGTGGCTTCGTCCTC	0.597000													5	28					0	0	0.248553	0	0
DRAXIN	374946	broad.mit.edu	37	1	11772462	11772462	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8096-01A-11D-2238-08	TCGA-55-8096-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	babd96af-bc23-49ee-b8ef-541bc076c7c4	fbc4dd00-fd9b-4988-aa44-ce1598a2150b	g.chr1:11772462G>A	ENST00000294485.5	+	5	958	c.823G>A	c.(823-825)Gac>Aac	p.D275N		NM_198545.3	NP_940947.3			dorsal inhibitory axon guidance protein																		GGAACCATGCGACCATCACCA	0.582000													19	110					0	0	0.608945	0	0
SEPT6	23157	broad.mit.edu	37	X	118797511	118797511	+	Missense_Mutation	SNP	T	T	C			TCGA-55-8096-01A-11D-2238-08	TCGA-55-8096-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	babd96af-bc23-49ee-b8ef-541bc076c7c4	fbc4dd00-fd9b-4988-aa44-ce1598a2150b	g.chrX:118797511T>C	ENST00000394610.1	-	3	539	c.275A>G	c.(274-276)aAc>aGc	p.N92S	SEPT6_ENST00000394617.2_Missense_Mutation_p.N122S|SEPT6_ENST00000343984.5_Missense_Mutation_p.N92S|SEPT6_ENST00000394616.4_Missense_Mutation_p.N34S|SEPT6_ENST00000360156.7_Missense_Mutation_p.N92S|SEPT6_ENST00000354416.3_Missense_Mutation_p.N92S|SEPT6_ENST00000354228.4_Missense_Mutation_p.N92S|SEPT6_ENST00000489216.1_Missense_Mutation_p.N92S	NM_145799.3	NP_665798.1	Q14141	SEPT6_HUMAN	septin 6	92					cell cycle|cytokinesis|interspecies interaction between organisms	cleavage furrow|condensed chromosome kinetochore|midbody|septin complex|spindle	GTP binding|protein binding			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(7)|ovary(1)|prostate(3)	17						TAGCCTCACGTTGCTCTCTTG	0.552000			T	MLL	AML								168	512					0	0	0.870114	0	0
GPR101	83550	broad.mit.edu	37	X	136113329	136113329	+	Missense_Mutation	SNP	C	C	T			TCGA-55-8096-01A-11D-2238-08	TCGA-55-8096-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	babd96af-bc23-49ee-b8ef-541bc076c7c4	fbc4dd00-fd9b-4988-aa44-ce1598a2150b	g.chrX:136113329C>T	ENST00000298110.1	-	1	504	c.505G>A	c.(505-507)Ggc>Agc	p.G169S		NM_054021.1	NP_473362.1	Q96P66	GP101_HUMAN	G protein-coupled receptor 101	169						integral to membrane|plasma membrane	G-protein coupled receptor activity	p.G169S(1)		autonomic_ganglia(1)|endometrium(5)|kidney(2)|large_intestine(11)|lung(18)|ovary(3)|skin(1)|urinary_tract(1)	42	Acute lymphoblastic leukemia(192;0.000127)					TGGCCCCAGCCGTAGAGTGGA	0.607000													4	57					0	0	0.150653	0	0
PLS1	5357	broad.mit.edu	37	3	142396905	142396905	+	Missense_Mutation	SNP	A	A	G			TCGA-55-8096-01A-11D-2238-08	TCGA-55-8096-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	babd96af-bc23-49ee-b8ef-541bc076c7c4	fbc4dd00-fd9b-4988-aa44-ce1598a2150b	g.chr3:142396905A>G	ENST00000337777.3	+	6	742	c.529A>G	c.(529-531)Att>Gtt	p.I177V	PLS1_ENST00000497002.1_Missense_Mutation_p.I177V|PLS1_ENST00000457734.2_Missense_Mutation_p.I177V	NM_002670.2	NP_002661.2	Q14651	PLSI_HUMAN	plastin 1	177	Actin-binding 1.|CH 1.					cytoplasm	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			NS(1)|breast(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(6)|lung(9)|ovary(1)|pancreas(1)|skin(1)|stomach(1)	27						ACCAGATACAATTGATGAAAG	0.289000													3	51					0	0	0.150653	0	0
U2AF2	11338	broad.mit.edu	37	19	56166501	56166501	+	Missense_Mutation	SNP	C	C	T			TCGA-55-8096-01A-11D-2238-08	TCGA-55-8096-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	babd96af-bc23-49ee-b8ef-541bc076c7c4	fbc4dd00-fd9b-4988-aa44-ce1598a2150b	g.chr19:56166501C>T	ENST00000450554.2	+	1	990	c.31C>T	c.(31-33)Ctc>Ttc	p.L11F	U2AF2_ENST00000308924.4_Missense_Mutation_p.L11F	NM_001012478.1|NM_007279.2	NP_001012496.1|NP_009210.1	P26368	U2AF2_HUMAN	U2 small nuclear RNA auxiliary factor 2	11					mRNA 3'-end processing|mRNA export from nucleus|termination of RNA polymerase II transcription	nucleoplasm|spliceosomal complex	enzyme binding|nucleotide binding|RNA binding			biliary_tract(1)|central_nervous_system(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(3)|lung(9)|ovary(1)|prostate(1)|urinary_tract(2)	21		Colorectal(82;0.00244)|Ovarian(87;0.133)	BRCA - Breast invasive adenocarcinoma(297;0.18)	GBM - Glioblastoma multiforme(193;0.107)		CGAGCGGCAGCTCAACGAGAA	0.682000													4	52					0	0	0.248553	0	0
FAM127C	441518	broad.mit.edu	37	X	134156269	134156269	+	Missense_Mutation	SNP	C	C	G			TCGA-55-8096-01A-11D-2238-08	TCGA-55-8096-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	babd96af-bc23-49ee-b8ef-541bc076c7c4	fbc4dd00-fd9b-4988-aa44-ce1598a2150b	g.chrX:134156269C>G	ENST00000391440.1	-	1	290	c.221G>C	c.(220-222)gGg>gCg	p.G74A		NM_001078173.1	NP_001071641.1	Q17RB0	F127C_HUMAN	family with sequence similarity 127, member C	74										breast(1)|endometrium(2)|large_intestine(1)|lung(2)	6	Acute lymphoblastic leukemia(192;0.000127)					CAGGGCGGGCCCCGTGAGGCG	0.602000													12	136					0	0	0.411799	0	0
CWF19L2	143884	broad.mit.edu	37	11	107205608	107205608	+	Splice_Site	SNP	G	G	C			TCGA-55-8096-01A-11D-2238-08	TCGA-55-8096-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	babd96af-bc23-49ee-b8ef-541bc076c7c4	fbc4dd00-fd9b-4988-aa44-ce1598a2150b	g.chr11:107205608G>C	ENST00000282251.5	-	16	2465	c.2439_splice	c.e16+1	p.S813_splice		NM_152434.2	NP_689647.2	Q2TBE0	C19L2_HUMAN	CWF19-like 2, cell cycle control (S. pombe)	813							catalytic activity			endometrium(4)|kidney(2)|large_intestine(13)|lung(21)	40		Melanoma(852;1.75e-05)|all_epithelial(67;6.27e-05)|Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0017)|Breast(348;0.0258)		Epithelial(105;7.18e-06)|BRCA - Breast invasive adenocarcinoma(274;1.65e-05)|all cancers(92;1.76e-05)		CATACTTACAGACTTTCTGAT	0.343000													8	74					0	0	0.335167	0	0
NXF2	56001	broad.mit.edu	37	X	101581405	101581405	+	Nonsense_Mutation	SNP	G	G	T			TCGA-55-8096-01A-11D-2238-08	TCGA-55-8096-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	babd96af-bc23-49ee-b8ef-541bc076c7c4	fbc4dd00-fd9b-4988-aa44-ce1598a2150b	g.chrX:101581405G>T	ENST00000395088.2	+	34	3730	c.1858G>T	c.(1858-1860)Gag>Tag	p.E620*	NXF2_ENST00000372763.1_3'UTR|NXF2_ENST00000372757.1_Nonsense_Mutation_p.E620*|NXF2_ENST00000372758.1_Nonsense_Mutation_p.E620*|NXF2_ENST00000330252.5_Nonsense_Mutation_p.E620*			Q9GZY0	NXF2_HUMAN	nuclear RNA export factor 2	620	TAP-C.				mRNA export from nucleus|multicellular organismal development	actin cytoskeleton|cytoplasm|nuclear RNA export factor complex	nucleocytoplasmic transporter activity|nucleotide binding|RNA binding			endometrium(2)|lung(2)	4						GATCCCCGCAGAGGCCTTCAA	0.512000													12	77					1.52009e-12	2.10627e-12	0.479597	1	0
SARNP	84324	broad.mit.edu	37	12	56211462	56211462	+	Silent	SNP	G	G	A			TCGA-55-8096-01A-11D-2238-08	TCGA-55-8096-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	babd96af-bc23-49ee-b8ef-541bc076c7c4	fbc4dd00-fd9b-4988-aa44-ce1598a2150b	g.chr12:56211462G>A	ENST00000336133.3	-	1	78	c.24C>T	c.(22-24)ctC>ctT	p.L8L	SARNP_ENST00000444631.2_5'UTR|SARNP_ENST00000552080.1_Silent_p.L8L|RP11-762I7.5_ENST00000546837.1_Intron|RP11-762I7.5_ENST00000552719.1_Intron	NM_033082.3	NP_149073.1			SAP domain containing ribonucleoprotein											breast(1)|endometrium(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	6						TTAGCTTATGGAGCTCCACCG	0.587000													14	125					0	0	0.539581	0	0
FMR1NB	158521	broad.mit.edu	37	X	147084783	147084783	+	Nonsense_Mutation	SNP	C	C	T			TCGA-55-8096-01A-11D-2238-08	TCGA-55-8096-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	babd96af-bc23-49ee-b8ef-541bc076c7c4	fbc4dd00-fd9b-4988-aa44-ce1598a2150b	g.chrX:147084783C>T	ENST00000370467.3	+	2	414	c.340C>T	c.(340-342)Caa>Taa	p.Q114*		NM_152578.2	NP_689791.1	Q8N0W7	FMR1N_HUMAN	fragile X mental retardation 1 neighbor	114						integral to membrane				breast(2)|cervix(1)|endometrium(3)|large_intestine(7)|lung(10)|ovary(1)|skin(1)	25	Acute lymphoblastic leukemia(192;6.56e-05)					TGCTCATGGCCAATCTCTGGA	0.358000													7	102					0	0	0.248553	0	0
KMT2D	8085	broad.mit.edu	37	12	49436376	49436376	+	Silent	SNP	T	T	A			TCGA-55-8096-01A-11D-2238-08	TCGA-55-8096-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	babd96af-bc23-49ee-b8ef-541bc076c7c4	fbc4dd00-fd9b-4988-aa44-ce1598a2150b	g.chr12:49436376T>A	ENST00000301067.7	-	27	5834	c.5835A>T	c.(5833-5835)ccA>ccT	p.P1945P		NM_003482.3	NP_003473.3			lysine (K)-specific methyltransferase 2D																		GGCAGAGGCCTGGGTAGGAGT	0.557000													4	22					0	0	0.184627	0	0
FIZ1	84922	broad.mit.edu	37	19	56104103	56104103	+	Missense_Mutation	SNP	C	C	G			TCGA-55-8096-01A-11D-2238-08	TCGA-55-8096-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	babd96af-bc23-49ee-b8ef-541bc076c7c4	fbc4dd00-fd9b-4988-aa44-ce1598a2150b	g.chr19:56104103C>G	ENST00000221665.3	-	3	1293	c.1204G>C	c.(1204-1206)Gaa>Caa	p.E402Q		NM_032836.2	NP_116225.2	Q96SL8	FIZ1_HUMAN	FLT3-interacting zinc finger 1	402					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	nucleic acid binding|protein kinase binding|receptor binding|zinc ion binding	p.E402K(1)		breast(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(5)	11			BRCA - Breast invasive adenocarcinoma(297;0.18)	GBM - Glioblastoma multiforme(193;0.107)		GACGGGGGTTCCCCGGACGCC	0.736000													7	65					0	0	0.278610	0	0
GRID2	2895	broad.mit.edu	37	4	94376964	94376964	+	Missense_Mutation	SNP	A	A	T			TCGA-55-8096-01A-11D-2238-08	TCGA-55-8096-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	babd96af-bc23-49ee-b8ef-541bc076c7c4	fbc4dd00-fd9b-4988-aa44-ce1598a2150b	g.chr4:94376964A>T	ENST00000282020.4	+	11	1955	c.1697A>T	c.(1696-1698)gAt>gTt	p.D566V	GRID2_ENST00000510992.1_Missense_Mutation_p.D471V	NM_001510.2	NP_001501.2	O43424	GRID2_HUMAN	glutamate receptor, ionotropic, delta 2	566					glutamate signaling pathway	cell junction|integral to plasma membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			NS(2)|breast(2)|central_nervous_system(1)|endometrium(6)|kidney(4)|large_intestine(18)|lung(45)|ovary(3)|prostate(6)|skin(9)|upper_aerodigestive_tract(3)|urinary_tract(1)	100		Hepatocellular(203;0.114)|all_hematologic(202;0.177)		OV - Ovarian serous cystadenocarcinoma(123;3.22e-06)|LUSC - Lung squamous cell carcinoma(81;0.185)|Lung(65;0.191)	L-Glutamic Acid(DB00142)	GCACCATTTGATCTCTCTCTA	0.488000													43	94					0	0	0.870114	0	0
NR0B1	190	broad.mit.edu	37	X	30327114	30327114	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8096-01A-11D-2238-08	TCGA-55-8096-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	babd96af-bc23-49ee-b8ef-541bc076c7c4	fbc4dd00-fd9b-4988-aa44-ce1598a2150b	g.chrX:30327114C>A	ENST00000378970.4	-	1	601	c.367G>T	c.(367-369)Ggg>Tgg	p.G123W	NR0B1_ENST00000453287.1_Missense_Mutation_p.G123W	NM_000475.4	NP_000466.2	P51843	NR0B1_HUMAN	nuclear receptor subfamily 0, group B, member 1	123	4 X 67 AA tandem repeats.				adrenal gland development|hypothalamus development|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of steroid hormone receptor signaling pathway|pituitary gland development|protein localization|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|steroid biosynthetic process	cytoplasm|membrane fraction|nucleoplasm|nucleus|polysomal ribosome	AF-2 domain binding|DNA hairpin binding|ligand-regulated transcription factor activity|protein domain specific binding|protein homodimerization activity|RNA binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|steroid hormone receptor binding|transcription corepressor activity|transcription factor binding			central_nervous_system(2)|endometrium(2)|large_intestine(4)|lung(13)|ovary(1)|skin(2)	24					Dexamethasone(DB01234)|Tretinoin(DB00755)	ACGGGCCGCCCACCCGGAAGC	0.672000											OREG0019719	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	22	44					1.66031e-10	2.17275e-10	0.667858	1	0
CHL1	10752	broad.mit.edu	37	3	432804	432804	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8096-01A-11D-2238-08	TCGA-55-8096-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	babd96af-bc23-49ee-b8ef-541bc076c7c4	fbc4dd00-fd9b-4988-aa44-ce1598a2150b	g.chr3:432804C>A	ENST00000256509.2	+	22	3395	c.2753C>A	c.(2752-2754)cCt>cAt	p.P918H	CHL1_ENST00000397491.2_Missense_Mutation_p.P902H	NM_001253387.1|NM_001253388.1|NM_006614.3	NP_001240316.1|NP_001240317.1|NP_006605.2	O00533	CHL1_HUMAN	cell adhesion molecule L1-like	902	Fibronectin type-III 4.				axon guidance|cell adhesion|signal transduction	integral to membrane|plasma membrane|proteinaceous extracellular matrix				NS(1)|central_nervous_system(5)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(25)|lung(31)|ovary(1)|prostate(4)|skin(10)|stomach(1)	93		all_cancers(2;1.14e-06)|all_epithelial(2;0.00367)|all_lung(1;0.061)|Lung NSC(2;0.201)		Epithelial(13;5.36e-06)|all cancers(10;1.4e-05)|OV - Ovarian serous cystadenocarcinoma(96;0.00323)|COAD - Colon adenocarcinoma(1;0.00925)|Colorectal(20;0.0198)		GGAGCTGGTCCTGAAAGTGAG	0.383000													7	60					0.00307968	0.00333108	0.278610	1	0
TTN	7273	broad.mit.edu	37	2	179579037	179579037	+	Missense_Mutation	SNP	C	C	T			TCGA-55-8096-01A-11D-2238-08	TCGA-55-8096-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	babd96af-bc23-49ee-b8ef-541bc076c7c4	fbc4dd00-fd9b-4988-aa44-ce1598a2150b	g.chr2:179579037C>T	ENST00000589042.1	-	91	26688	c.26464G>A	c.(26464-26466)Gcc>Acc	p.A8822T	TTN_ENST00000342992.6_Missense_Mutation_p.A7578T|TTN_ENST00000591111.1_Missense_Mutation_p.A8505T|TTN_ENST00000342175.6_Intron|TTN_ENST00000359218.5_Intron|TTN_ENST00000460472.2_Intron|TTN-AS1_ENST00000585451.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	8505	Ig-like 71.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GATAGCGTGGCGAAGCACTCT	0.403000													16	152					0	0	0.592651	0	0
ARL13A	392509	broad.mit.edu	37	X	100242379	100242379	+	Splice_Site	SNP	G	G	T			TCGA-55-8096-01A-11D-2238-08	TCGA-55-8096-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	babd96af-bc23-49ee-b8ef-541bc076c7c4	fbc4dd00-fd9b-4988-aa44-ce1598a2150b	g.chrX:100242379G>T	ENST00000450049.2	+	6	600	c.486_splice	c.e6-1	p.E163_splice		NM_001162491.1	NP_001155963.1	Q5H913	AR13A_HUMAN	ADP-ribosylation factor-like 13A	163							GTP binding			endometrium(1)|ovary(1)	2						TTTGTCACAGGAGCCATGTTC	0.498000													4	32					2.56e-06	3.10126e-06	0.150653	1	0
ANAPC1	64682	broad.mit.edu	37	2	112601107	112601107	+	Nonsense_Mutation	SNP	C	C	T			TCGA-55-8096-01A-11D-2238-08	TCGA-55-8096-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	babd96af-bc23-49ee-b8ef-541bc076c7c4	fbc4dd00-fd9b-4988-aa44-ce1598a2150b	g.chr2:112601107C>T	ENST00000341068.3	-	17	2694	c.1922G>A	c.(1921-1923)tGg>tAg	p.W641*		NM_022662.3	NP_073153.1	Q9H1A4	APC1_HUMAN	anaphase promoting complex subunit 1	641					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination	anaphase-promoting complex|cytosol|nucleoplasm				NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(6)|kidney(4)|large_intestine(7)|lung(16)|pancreas(1)|prostate(3)|skin(5)|stomach(1)|urinary_tract(1)	49						GACATTGTACCACTTGACAAG	0.383000													11	29					0	0	0.457914	0	0
LMAN2	10960	broad.mit.edu	37	5	176778294	176778294	+	Splice_Site	SNP	T	T	A			TCGA-55-8096-01A-11D-2238-08	TCGA-55-8096-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	babd96af-bc23-49ee-b8ef-541bc076c7c4	fbc4dd00-fd9b-4988-aa44-ce1598a2150b	g.chr5:176778294T>A	ENST00000303127.7	-	2	401		c.e2-2		LMAN2_ENST00000506310.1_Splice_Site|LMAN2_ENST00000515209.1_Splice_Site	NM_006816.2	NP_006807.1	Q12907	LMAN2_HUMAN	lectin, mannose-binding 2						protein transport	endoplasmic reticulum membrane|ER-Golgi intermediate compartment membrane|Golgi membrane|integral to membrane	metal ion binding|sugar binding			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(6)|upper_aerodigestive_tract(1)	16	all_cancers(89;2.04e-05)|Renal(175;0.000269)|Lung NSC(126;0.000832)|all_lung(126;0.00152)	all_neural(177;0.00802)|Medulloblastoma(196;0.0145)|all_hematologic(541;0.248)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			AACCGACCCCTGTGGGAAGAG	0.612000													13	68					0	0	0.479597	0	0
PTPRB	5787	broad.mit.edu	37	12	70956766	70956766	+	Silent	SNP	C	C	A			TCGA-55-8096-01A-11D-2238-08	TCGA-55-8096-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	babd96af-bc23-49ee-b8ef-541bc076c7c4	fbc4dd00-fd9b-4988-aa44-ce1598a2150b	g.chr12:70956766C>A	ENST00000334414.6	-	16	4070	c.4026G>T	c.(4024-4026)ggG>ggT	p.G1342G	PTPRB_ENST00000451516.2_Silent_p.G1034G|PTPRB_ENST00000550358.1_Silent_p.G1254G|PTPRB_ENST00000261266.5_Silent_p.G1124G|PTPRB_ENST00000538708.1_Silent_p.G1034G|PTPRB_ENST00000551525.1_Silent_p.G1341G|PTPRB_ENST00000550857.1_Silent_p.G1034G	NM_001109754.2	NP_001103224.1	P23467	PTPRB_HUMAN	protein tyrosine phosphatase, receptor type, B	1124	Fibronectin type-III 15.				angiogenesis	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			breast(4)|central_nervous_system(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(8)|lung(46)|prostate(4)|skin(18)|upper_aerodigestive_tract(1)|urinary_tract(3)	107	Renal(347;0.236)		GBM - Glioblastoma multiforme(2;2.17e-05)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00306)|STAD - Stomach adenocarcinoma(21;0.149)			CCTGGAGATTCCCATCTGGGT	0.507000													7	60					0.000157383	0.000181333	0.278610	1	0
PHLDB1	23187	broad.mit.edu	37	11	118498936	118498936	+	Missense_Mutation	SNP	G	G	T	rs140294013		TCGA-55-8096-01A-11D-2238-08	TCGA-55-8096-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	babd96af-bc23-49ee-b8ef-541bc076c7c4	fbc4dd00-fd9b-4988-aa44-ce1598a2150b	g.chr11:118498936G>T	ENST00000361417.2	+	7	1808	c.1397G>T	c.(1396-1398)cGg>cTg	p.R466L	PHLDB1_ENST00000356063.5_Missense_Mutation_p.R466L	NM_015157.3	NP_055972.1	Q86UU1	PHLB1_HUMAN	pleckstrin homology-like domain, family B, member 1	466										breast(3)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(10)|liver(3)|lung(14)|ovary(2)|pancreas(1)|prostate(3)|skin(1)	46	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0523)|all_hematologic(192;0.0735)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;3.4e-05)		TCTCTGTCCCGGCGAGCTCTC	0.677000													25	186					1.39806e-14	2.03005e-14	0.729181	1	0
OR13F1	138805	broad.mit.edu	37	9	107266683	107266683	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8096-01A-11D-2238-08	TCGA-55-8096-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	babd96af-bc23-49ee-b8ef-541bc076c7c4	fbc4dd00-fd9b-4988-aa44-ce1598a2150b	g.chr9:107266683C>A	ENST00000334726.2	+	1	229	c.140C>A	c.(139-141)tCc>tAc	p.S47Y		NM_001004485.1	NP_001004485.1	Q8NGS4	O13F1_HUMAN	olfactory receptor, family 13, subfamily F, member 1	47					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|large_intestine(6)|lung(17)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	31						TTTCTGATCTCCATCACCATT	0.478000													15	124					6.94344e-10	8.97567e-10	0.539581	1	0
RMDN3	55177	broad.mit.edu	37	15	41037425	41037425	+	Missense_Mutation	SNP	T	T	A			TCGA-55-8096-01A-11D-2238-08	TCGA-55-8096-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	babd96af-bc23-49ee-b8ef-541bc076c7c4	fbc4dd00-fd9b-4988-aa44-ce1598a2150b	g.chr15:41037425T>A	ENST00000260385.6	-	4	1624	c.557A>T	c.(556-558)gAg>gTg	p.E186V	RMDN3_ENST00000338376.3_Missense_Mutation_p.E186V|RMDN3_ENST00000558560.1_5'UTR					regulator of microtubule dynamics 3																		AGAGTCCCGCTCATTGTCAGA	0.498000													13	102					0	0	0.500413	0	0
MUC16	94025	broad.mit.edu	37	19	9084154	9084154	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8096-01A-11D-2238-08	TCGA-55-8096-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	babd96af-bc23-49ee-b8ef-541bc076c7c4	fbc4dd00-fd9b-4988-aa44-ce1598a2150b	g.chr19:9084154G>T	ENST00000397910.4	-	1	7864	c.7661C>A	c.(7660-7662)tCc>tAc	p.S2554Y		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	2554	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TGTAGCACTGGATCCAGTGAC	0.512000													5	51					3.59834e-05	4.26172e-05	0.217242	1	0
SCN2B	6327	broad.mit.edu	37	11	118039448	118039448	+	Missense_Mutation	SNP	A	A	G			TCGA-55-8096-01A-11D-2238-08	TCGA-55-8096-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	babd96af-bc23-49ee-b8ef-541bc076c7c4	fbc4dd00-fd9b-4988-aa44-ce1598a2150b	g.chr11:118039448A>G	ENST00000278947.5	-	2	330	c.89T>C	c.(88-90)aTg>aCg	p.M30T		NM_004588.4	NP_004579.1	O60939	SCN2B_HUMAN	sodium channel, voltage-gated, type II, beta subunit	30					synaptic transmission	voltage-gated sodium channel complex	voltage-gated sodium channel activity			haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(2)	7	all_hematologic(175;0.046)	Medulloblastoma(222;0.0425)|Breast(348;0.181)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;3.19e-05)|Epithelial(105;0.00117)		TGTGACCTCCATGCTCCGTCC	0.602000													31	237					0	0	0.760397	0	0
SHQ1	55164	broad.mit.edu	37	3	72897456	72897456	+	Silent	SNP	C	C	A			TCGA-55-8096-01A-11D-2238-08	TCGA-55-8096-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	babd96af-bc23-49ee-b8ef-541bc076c7c4	fbc4dd00-fd9b-4988-aa44-ce1598a2150b	g.chr3:72897456C>A	ENST00000325599.8	-	1	175	c.36G>T	c.(34-36)ccG>ccT	p.P12P		NM_018130.2	NP_060600.2	Q6PI26	SHQ1_HUMAN	SHQ1, H/ACA ribonucleoprotein assembly factor	12	CS.				ribonucleoprotein complex assembly	cytosol|nucleoplasm	protein binding			NS(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(8)|ovary(2)|prostate(1)|skin(2)|urinary_tract(1)	27		Prostate(10;0.00482)|Lung NSC(201;0.0339)|Myeloproliferative disorder(1037;0.204)		BRCA - Breast invasive adenocarcinoma(55;9.68e-05)|Epithelial(33;0.000563)|LUSC - Lung squamous cell carcinoma(21;0.00229)|Lung(16;0.00688)|KIRC - Kidney renal clear cell carcinoma(39;0.018)|Kidney(39;0.0213)		TCAGGAAGTCCGGATCCTGGC	0.657000													20	146					5.26018e-13	7.43439e-13	0.608945	1	0
LRP10	26020	broad.mit.edu	37	14	23345405	23345405	+	Nonsense_Mutation	SNP	G	G	A			TCGA-55-8096-01A-11D-2238-08	TCGA-55-8096-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	babd96af-bc23-49ee-b8ef-541bc076c7c4	fbc4dd00-fd9b-4988-aa44-ce1598a2150b	g.chr14:23345405G>A	ENST00000359591.4	+	5	1939	c.1248G>A	c.(1246-1248)tgG>tgA	p.W416*	LRP10_ENST00000546834.1_Nonsense_Mutation_p.W416*	NM_014045.3	NP_054764.2	Q7Z4F1	LRP10_HUMAN	low density lipoprotein receptor-related protein 10	416	LDL-receptor class A 4.				endocytosis	coated pit|integral to membrane				central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|liver(2)|lung(7)|ovary(2)|prostate(2)|skin(5)|stomach(1)|urinary_tract(2)	32	all_cancers(95;4.69e-05)			GBM - Glioblastoma multiforme(265;0.00549)		ATGAGACGTGGGTGTGCGATG	0.582000													23	246					0	0	0.729181	0	0
C9orf96	169436	broad.mit.edu	37	9	136260873	136260873	+	Silent	SNP	G	G	A			TCGA-55-8096-01A-11D-2238-08	TCGA-55-8096-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	babd96af-bc23-49ee-b8ef-541bc076c7c4	fbc4dd00-fd9b-4988-aa44-ce1598a2150b	g.chr9:136260873G>A	ENST00000371957.3	+	9	956	c.849G>A	c.(847-849)tcG>tcA	p.S283S	C9orf96_ENST00000371955.1_5'UTR	NM_153710.3	NP_714921.3	Q8NE28	SGK71_HUMAN	chromosome 9 open reading frame 96	283	Protein kinase.						ATP binding|protein kinase activity			autonomic_ganglia(1)|central_nervous_system(3)|endometrium(1)|kidney(1)|large_intestine(5)|lung(10)|ovary(2)|stomach(2)	25				OV - Ovarian serous cystadenocarcinoma(145;1.06e-07)|Epithelial(140;1.28e-06)|all cancers(34;1.46e-05)		TCGACCCCTCGGATCGAATAA	0.493000													5	80					0	0	0.184627	0	0
FNDC8	54752	broad.mit.edu	37	17	33454199	33454199	+	Silent	SNP	G	G	A			TCGA-55-8096-01A-11D-2238-08	TCGA-55-8096-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	babd96af-bc23-49ee-b8ef-541bc076c7c4	fbc4dd00-fd9b-4988-aa44-ce1598a2150b	g.chr17:33454199G>A	ENST00000158009.5	+	2	463	c.348G>A	c.(346-348)ggG>ggA	p.G116G		NM_017559.2	NP_060029.1	Q8TC99	FNDC8_HUMAN	fibronectin type III domain containing 8	116										breast(1)|kidney(1)|large_intestine(3)|lung(3)|ovary(2)|skin(1)	11		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.022)		TGCTGGAGGGGGAGCTGAACA	0.562000													7	274					0	0	0.278610	0	0
IGHV3-35	28432	broad.mit.edu	37	14	106845353	106845353	+	RNA	SNP	G	G	A			TCGA-55-8096-01A-11D-2238-08	TCGA-55-8096-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	babd96af-bc23-49ee-b8ef-541bc076c7c4	fbc4dd00-fd9b-4988-aa44-ce1598a2150b	g.chr14:106845353G>A	ENST00000390617.2	-	0	335																											CCGTGTCCTCGGCCCTCAGGC	0.527000													15	189					0	0	0.608945	0	0
NLRP9	338321	broad.mit.edu	37	19	56249556	56249556	+	Missense_Mutation	SNP	T	T	A			TCGA-55-8096-01A-11D-2238-08	TCGA-55-8096-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	babd96af-bc23-49ee-b8ef-541bc076c7c4	fbc4dd00-fd9b-4988-aa44-ce1598a2150b	g.chr19:56249556T>A	ENST00000332836.2	-	1	212	c.185A>T	c.(184-186)cAt>cTt	p.H62L		NM_176820.2	NP_789790.2	Q7RTR0	NALP9_HUMAN	NLR family, pyrin domain containing 9	62	DAPIN.					cytoplasm	ATP binding			NS(2)|breast(5)|cervix(1)|endometrium(7)|kidney(8)|large_intestine(15)|lung(21)|ovary(2)|prostate(3)|skin(7)|urinary_tract(3)	74		Colorectal(82;0.000133)|Ovarian(87;0.133)		GBM - Glioblastoma multiforme(193;0.123)		TCCTGGGTAATGTTTGTCCAG	0.463000													152	428					0	0	0.870114	0	0
UTP18	51096	broad.mit.edu	37	17	49371270	49371270	+	Missense_Mutation	SNP	C	C	G			TCGA-55-8096-01A-11D-2238-08	TCGA-55-8096-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	babd96af-bc23-49ee-b8ef-541bc076c7c4	fbc4dd00-fd9b-4988-aa44-ce1598a2150b	g.chr17:49371270C>G	ENST00000225298.7	+	12	1567	c.1510C>G	c.(1510-1512)Ctt>Gtt	p.L504V		NM_016001.2	NP_057085.2	Q9Y5J1	UTP18_HUMAN	UTP18 small subunit (SSU) processome component homolog (yeast)	504					rRNA processing	nucleolus				breast(2)|endometrium(3)|kidney(2)|lung(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	16			BRCA - Breast invasive adenocarcinoma(22;2.09e-07)			GCAGGTTCATCTTCCTTCCTG	0.338000													3	37					0	0	0.115264	0	0
DNAJC2	27000	broad.mit.edu	37	7	102967069	102967069	+	Missense_Mutation	SNP	C	C	G			TCGA-55-8096-01A-11D-2238-08	TCGA-55-8096-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	babd96af-bc23-49ee-b8ef-541bc076c7c4	fbc4dd00-fd9b-4988-aa44-ce1598a2150b	g.chr7:102967069C>G	ENST00000379263.3	-	5	743	c.493G>C	c.(493-495)Gat>Cat	p.D165H	DNAJC2_ENST00000249270.7_Missense_Mutation_p.D165H|PMPCB_ENST00000420236.2_Intron	NM_014377.1	NP_055192.1	Q99543	DNJC2_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 2	165	ZRF1-UBD.				'de novo' cotranslational protein folding|chromatin modification|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nuclear membrane	chromatin binding|DNA binding|histone binding|Hsp70 protein binding|ubiquitin binding			endometrium(1)|kidney(9)|large_intestine(6)|lung(4)|ovary(1)	21						ACTGAGTTATCAAAAGTAGGA	0.348000													5	42					0	0	0.184627	0	0
LILRP2	79166	broad.mit.edu	37	19	55221570	55221570	+	RNA	SNP	A	A	C			TCGA-55-8096-01A-11D-2238-08	TCGA-55-8096-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	babd96af-bc23-49ee-b8ef-541bc076c7c4	fbc4dd00-fd9b-4988-aa44-ce1598a2150b	g.chr19:55221570A>C	ENST00000413439.1	+	0	1350																											TACAGATGCTACGGTGCACAC	0.677000													3	99					0	0	0.411799	0	0
LRP10	26020	broad.mit.edu	37	14	23345406	23345406	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8096-01A-11D-2238-08	TCGA-55-8096-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	babd96af-bc23-49ee-b8ef-541bc076c7c4	fbc4dd00-fd9b-4988-aa44-ce1598a2150b	g.chr14:23345406G>T	ENST00000359591.4	+	5	1940	c.1249G>T	c.(1249-1251)Gtg>Ttg	p.V417L	LRP10_ENST00000546834.1_Missense_Mutation_p.V417L	NM_014045.3	NP_054764.2	Q7Z4F1	LRP10_HUMAN	low density lipoprotein receptor-related protein 10	417	LDL-receptor class A 4.				endocytosis	coated pit|integral to membrane				central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|liver(2)|lung(7)|ovary(2)|prostate(2)|skin(5)|stomach(1)|urinary_tract(2)	32	all_cancers(95;4.69e-05)			GBM - Glioblastoma multiforme(265;0.00549)		TGAGACGTGGGTGTGCGATGG	0.582000													23	244					1.30897e-18	2.02556e-18	0.740014	1	0
ZFHX4	79776	broad.mit.edu	37	8	77767654	77767654	+	Missense_Mutation	SNP	G	G	C			TCGA-55-8096-01A-11D-2238-08	TCGA-55-8096-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	babd96af-bc23-49ee-b8ef-541bc076c7c4	fbc4dd00-fd9b-4988-aa44-ce1598a2150b	g.chr8:77767654G>C	ENST00000521891.2	+	10	8945	c.8497G>C	c.(8497-8499)Gtg>Ctg	p.V2833L	ZFHX4_ENST00000518282.1_Missense_Mutation_p.V2807L|ZFHX4_ENST00000455469.2_Missense_Mutation_p.V2788L|ZFHX4_ENST00000050961.6_Missense_Mutation_p.V2788L	NM_024721.4	NP_078997.4	Q86UP3	ZFHX4_HUMAN	zinc finger homeobox 4	2788						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(3)|breast(11)|central_nervous_system(1)|endometrium(36)|haematopoietic_and_lymphoid_tissue(2)|kidney(15)|large_intestine(66)|liver(2)|lung(245)|ovary(11)|pancreas(3)|prostate(11)|skin(7)|upper_aerodigestive_tract(13)|urinary_tract(6)	432			BRCA - Breast invasive adenocarcinoma(89;0.0895)			TTCCGGAGATGTGAAACCGGC	0.483000										HNSCC(33;0.089)			7	56					0	0	0.248553	0	0
DCAF12L1	139170	broad.mit.edu	37	X	125685650	125685650	+	Nonsense_Mutation	SNP	G	G	T			TCGA-55-8096-01A-11D-2238-08	TCGA-55-8096-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	babd96af-bc23-49ee-b8ef-541bc076c7c4	fbc4dd00-fd9b-4988-aa44-ce1598a2150b	g.chrX:125685650G>T	ENST00000371126.1	-	1	1184	c.942C>A	c.(940-942)taC>taA	p.Y314*		NM_178470.4	NP_848565.2	Q5VU92	DC121_HUMAN	DDB1 and CUL4 associated factor 12-like 1	314										breast(1)|central_nervous_system(3)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(6)|lung(39)|ovary(2)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	68						TATCATCACAGTAGGTCAGGC	0.587000													33	119					4.11147e-13	5.84988e-13	0.788014	1	0
RYR2	6262	broad.mit.edu	37	1	237754118	237754118	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8096-01A-11D-2238-08	TCGA-55-8096-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	babd96af-bc23-49ee-b8ef-541bc076c7c4	fbc4dd00-fd9b-4988-aa44-ce1598a2150b	g.chr1:237754118G>T	ENST00000366574.2	+	31	4303	c.3986G>T	c.(3985-3987)gGg>gTg	p.G1329V	RYR2_ENST00000360064.6_Missense_Mutation_p.G1327V|RYR2_ENST00000542537.1_Missense_Mutation_p.G1313V	NM_001035.2	NP_001026.2	Q92736	RYR2_HUMAN	ryanodine receptor 2 (cardiac)	1329	4 X approximate repeats.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding	p.G1327V(1)		NS(4)|breast(8)|central_nervous_system(11)|cervix(2)|endometrium(39)|haematopoietic_and_lymphoid_tissue(5)|kidney(17)|large_intestine(83)|liver(4)|lung(353)|ovary(18)|pancreas(5)|prostate(12)|skin(8)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(4)	586	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			GGCCTTTTTGGGCCCAAGAAT	0.517000													21	82					4.7796e-09	6.06752e-09	0.681144	1	0
TCHP	84260	broad.mit.edu	37	12	110341741	110341741	+	Splice_Site	SNP	G	G	T			TCGA-55-8096-01A-11D-2238-08	TCGA-55-8096-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	babd96af-bc23-49ee-b8ef-541bc076c7c4	fbc4dd00-fd9b-4988-aa44-ce1598a2150b	g.chr12:110341741G>T	ENST00000312777.5	+	3	402		c.e3-1		TCHP_ENST00000405876.4_Splice_Site	NM_032300.4	NP_115676.1	Q9BT92	TCHP_HUMAN	trichoplein, keratin filament binding						apoptosis|negative regulation of cell growth	apical cortex|centrosome|keratin filament|mitochondrion|plasma membrane	protein binding			NS(1)|breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(8)|ovary(1)|skin(2)	22						CTCTCACCCAGCATGCATGCC	0.572000													4	14					0.184627	0.187277	0.184627	1	0
MMEL1	79258	broad.mit.edu	37	1	2560819	2560821	+	In_Frame_Del	DEL	CAG	CAG	-			TCGA-55-8096-01A-11D-2238-08	TCGA-55-8096-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	babd96af-bc23-49ee-b8ef-541bc076c7c4	fbc4dd00-fd9b-4988-aa44-ce1598a2150b	g.chr1:2560819_2560821delCAG	ENST00000288709.6	-	2	316_318	c.76_78delCTG	c.(76-78)del	p.L26del	MMEL1_ENST00000502556.1_In_Frame_Del_p.L35del|MMEL1_ENST00000378412.3_In_Frame_Del_p.L35del	NM_033467.3	NP_258428.2	Q495T6	MMEL1_HUMAN	membrane metallo-endopeptidase-like 1	35					proteolysis	extracellular region|integral to membrane|intracellular membrane-bounded organelle	metal ion binding|metalloendopeptidase activity			cervix(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(1)|lung(13)|ovary(2)|prostate(1)|urinary_tract(1)	27	all_cancers(77;0.000233)|all_epithelial(69;8.55e-05)|all_lung(157;0.0228)|Lung NSC(156;0.0402)|Ovarian(185;0.0634)	all_epithelial(116;1.03e-20)|all_lung(118;5.15e-09)|Lung NSC(185;9.02e-07)|Breast(487;0.00147)|Renal(390;0.00183)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.0847)|Medulloblastoma(700;0.123)		Epithelial(90;4.31e-38)|OV - Ovarian serous cystadenocarcinoma(86;8.52e-23)|GBM - Glioblastoma multiforme(42;1.49e-08)|Colorectal(212;4.79e-05)|COAD - Colon adenocarcinoma(227;0.000213)|Kidney(185;0.000371)|BRCA - Breast invasive adenocarcinoma(365;0.00219)|KIRC - Kidney renal clear cell carcinoma(229;0.00571)|STAD - Stomach adenocarcinoma(132;0.00645)|Lung(427;0.131)		CAGCGGTCACcagcagcagcagc	0.739													3	5	---	---	---	---					
RP11-435B5.5	0	broad.mit.edu	37	1	143391923	143391924	+	RNA	DEL	AT	AT	-			TCGA-55-8096-01A-11D-2238-08	TCGA-55-8096-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	babd96af-bc23-49ee-b8ef-541bc076c7c4	fbc4dd00-fd9b-4988-aa44-ce1598a2150b	g.chr1:143391923_143391924delAT	ENST00000428624.1	+	0	2065				RP11-435B5.4_ENST00000423249.1_lincRNA																							TATTTTGGAGATATATATATAT	0.262													2	4	---	---	---	---					
ARMC9	80210	broad.mit.edu	37	2	232146846	232146846	+	Splice_Site	DEL	G	G	-			TCGA-55-8096-01A-11D-2238-08	TCGA-55-8096-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	babd96af-bc23-49ee-b8ef-541bc076c7c4	fbc4dd00-fd9b-4988-aa44-ce1598a2150b	g.chr2:232146846delG	ENST00000349938.4	+	17	1820	c.1626_splice	c.e17+1	p.M542_splice	ARMC9_ENST00000483477.1_3'UTR	NM_001271466.1|NM_025139.3	NP_001258395.1|NP_079415.3	Q7Z3E5	ARMC9_HUMAN	armadillo repeat containing 9	542							binding			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(5)|ovary(2)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	22		Renal(207;0.0112)|all_lung(227;0.0744)|all_hematologic(139;0.0749)|Acute lymphoblastic leukemia(138;0.167)|Medulloblastoma(418;0.184)|Lung NSC(271;0.205)		Epithelial(121;1.43e-10)|LUSC - Lung squamous cell carcinoma(224;0.017)|Lung(119;0.0189)		CAAGAGCAATGGTAAGAAAGC	0.458													25	62	---	---	---	---					
COL22A1	169044	broad.mit.edu	37	8	139809072	139809072	+	Frame_Shift_Del	DEL	T	T	-			TCGA-55-8096-01A-11D-2238-08	TCGA-55-8096-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	babd96af-bc23-49ee-b8ef-541bc076c7c4	fbc4dd00-fd9b-4988-aa44-ce1598a2150b	g.chr8:139809072delT	ENST00000303045.6	-	12	2032	c.1586delA	c.(1585-1587)agfs	p.K529fs	COL22A1_ENST00000435777.1_Frame_Shift_Del_p.K529fs	NM_152888.1	NP_690848.1	Q8NFW1	COMA1_HUMAN	collagen, type XXII, alpha 1	529	Collagen-like 2.|Gly-rich.|Pro-rich.				cell adhesion	collagen|cytoplasm	structural molecule activity			breast(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(14)|large_intestine(29)|lung(107)|ovary(13)|pancreas(1)|prostate(3)|skin(12)|upper_aerodigestive_tract(15)|urinary_tract(4)	211	all_epithelial(106;1.55e-12)|Lung NSC(106;1.67e-05)|all_lung(105;3.39e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0517)			CTTTTCACCCTTTTCCCCTTG	0.463										HNSCC(7;0.00092)			7	694	---	---	---	---					
PRB3	5544	broad.mit.edu	37	12	11420620	11420620	+	RNA	DEL	G	G	-	rs71057717		TCGA-55-8096-01A-11D-2238-08	TCGA-55-8096-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	babd96af-bc23-49ee-b8ef-541bc076c7c4	fbc4dd00-fd9b-4988-aa44-ce1598a2150b	g.chr12:11420620delG	ENST00000381842.3	-	0	600				PRB3_ENST00000538488.1_RNA|PRB3_ENST00000279573.6_RNA|PRB3_ENST00000440870.3_RNA	NM_006249.4	NP_006240.4	Q04118	PRB3_HUMAN	proline-rich protein BstNI subfamily 3							extracellular region	Gram-negative bacterial cell surface binding	p.P188Q(1)|p.P167Q(1)		breast(2)|endometrium(1)|kidney(2)|large_intestine(1)|lung(13)|ovary(1)|skin(5)	25			OV - Ovarian serous cystadenocarcinoma(49;0.201)			TCCTCCTTGTGGGGGTGGTCC	0.647													57	233	---	---	---	---					
RP11-377D9.3	0	broad.mit.edu	37	12	13174142	13174147	+	RNA	DEL	AACAAC	AACAAC	-	rs113537246		TCGA-55-8096-01A-11D-2238-08	TCGA-55-8096-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	babd96af-bc23-49ee-b8ef-541bc076c7c4	fbc4dd00-fd9b-4988-aa44-ce1598a2150b	g.chr12:13174142_13174147delAACAAC	ENST00000543321.1	+	0	1025																											ctgtctcaaaaacaacaacaacaaca	0.553													6	6	---	---	---	---					
ELMSAN1	91748	broad.mit.edu	37	14	74188044	74188044	+	Frame_Shift_Del	DEL	C	C	-			TCGA-55-8096-01A-11D-2238-08	TCGA-55-8096-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	babd96af-bc23-49ee-b8ef-541bc076c7c4	fbc4dd00-fd9b-4988-aa44-ce1598a2150b	g.chr14:74188044delC	ENST00000286523.5	-	11	3675	c.2893delG	c.(2893-2895)cafs	p.A967fs	ELMSAN1_ENST00000394071.2_Frame_Shift_Del_p.A967fs	NM_194278.3	NP_919254.2			ELM2 and Myb/SANT-like domain containing 1																		ACTGCCGCTGCCCGCCTGCTG	0.647													23	105	---	---	---	---					
RP11-519G16.3	0	broad.mit.edu	37	15	45754119	45754121	+	RNA	DEL	CAC	CAC	-			TCGA-55-8096-01A-11D-2238-08	TCGA-55-8096-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	babd96af-bc23-49ee-b8ef-541bc076c7c4	fbc4dd00-fd9b-4988-aa44-ce1598a2150b	g.chr15:45754119_45754121delCAC	ENST00000560077.1	+	0	41				RP11-519G16.3_ENST00000558536.1_RNA|RP11-519G16.3_ENST00000560647.1_RNA																							ccaccaccatcaccaccaccacc	0.571													4	4	---	---	---	---					
ITGAD	3681	broad.mit.edu	37	16	31422756	31422756	+	Frame_Shift_Del	DEL	C	C	-			TCGA-55-8096-01A-11D-2238-08	TCGA-55-8096-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	babd96af-bc23-49ee-b8ef-541bc076c7c4	fbc4dd00-fd9b-4988-aa44-ce1598a2150b	g.chr16:31422756delC	ENST00000389202.2	+	14	1674	c.1625delC	c.(1624-1626)gcfs	p.A542fs		NM_005353.2	NP_005344.2	Q13349	ITAD_HUMAN	integrin, alpha D	542					cell-cell adhesion|cell-matrix adhesion|immune response|integrin-mediated signaling pathway	integrin complex	receptor activity			breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|liver(2)|lung(43)|ovary(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	71						GCCATTGGGGCCCCGGGAGAG	0.647													7	598	---	---	---	---					
AFG3L1P	172	broad.mit.edu	37	16	90053797	90053797	+	RNA	DEL	G	G	-			TCGA-55-8096-01A-11D-2238-08	TCGA-55-8096-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	babd96af-bc23-49ee-b8ef-541bc076c7c4	fbc4dd00-fd9b-4988-aa44-ce1598a2150b	g.chr16:90053797delG	ENST00000437774.1	+	0	731					NR_003226.1																						aggtggaggaggtggaggagg	0.647													2	4	---	---	---	---					
CNTROB	116840	broad.mit.edu	37	17	7843518	7843519	+	Frame_Shift_Del	DEL	GA	GA	-			TCGA-55-8096-01A-11D-2238-08	TCGA-55-8096-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	babd96af-bc23-49ee-b8ef-541bc076c7c4	fbc4dd00-fd9b-4988-aa44-ce1598a2150b	g.chr17:7843518_7843519delGA	ENST00000380262.3	+	9	2194_2195	c.1269_1270delGA	c.(1267-1272)cggafs	p.RR423fs	CNTROB_ENST00000380255.3_Frame_Shift_Del_p.RR423fs|CNTROB_ENST00000565740.1_Frame_Shift_Del_p.RR423fs|CNTROB_ENST00000563694.1_Frame_Shift_Del_p.RR423fs	NM_001037144.5	NP_001032221.1	Q8N137	CNTRB_HUMAN	centrobin, centrosomal BRCA2 interacting protein	423	Required for centrosome localization.				centriole replication|centrosome separation|cytokinesis	centriole	protein domain specific binding			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(8)|lung(9)	25		Prostate(122;0.173)				ATACAGCTCGGAGAGAGAGAGA	0.579													9	204	---	---	---	---					
CCDC178	374864	broad.mit.edu	37	18	30913143	30913143	+	Frame_Shift_Del	DEL	T	T	-			TCGA-55-8096-01A-11D-2238-08	TCGA-55-8096-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	babd96af-bc23-49ee-b8ef-541bc076c7c4	fbc4dd00-fd9b-4988-aa44-ce1598a2150b	g.chr18:30913143delT	ENST00000383096.3	-	10	1056	c.874delA	c.(874-876)tgfs	p.M292fs	CCDC178_ENST00000579916.1_Intron|CCDC178_ENST00000583930.1_Frame_Shift_Del_p.M292fs|CCDC178_ENST00000579947.1_Frame_Shift_Del_p.M292fs|CCDC178_ENST00000406524.2_Frame_Shift_Del_p.M292fs|CCDC178_ENST00000402325.1_Frame_Shift_Del_p.M292fs|CCDC178_ENST00000300227.8_Frame_Shift_Del_p.M292fs|CCDC178_ENST00000403303.1_Frame_Shift_Del_p.M292fs					coiled-coil domain containing 178									p.M292fs*3(2)									TTTACCTCCATTTTTTTTTTA	0.318													11	42	---	---	---	---					
SYNJ1	8867	broad.mit.edu	37	21	34011346	34011351	+	In_Frame_Del	DEL	GCTCTT	GCTCTT	-			TCGA-55-8096-01A-11D-2238-08	TCGA-55-8096-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	babd96af-bc23-49ee-b8ef-541bc076c7c4	fbc4dd00-fd9b-4988-aa44-ce1598a2150b	g.chr21:34011346_34011351delGCTCTT	ENST00000382499.2	-	31	3898_3903	c.3899_3904delAAGAGC	c.(3898-3906)cct>c	p.QEP1300del	SYNJ1_ENST00000322229.7_In_Frame_Del_p.QEP1261del|SYNJ1_ENST00000433931.2_In_Frame_Del_p.QEP1300del|SYNJ1_ENST00000382491.3_In_Frame_Del_p.QEP1214del|SYNJ1_ENST00000357345.3_In_Frame_Del_p.QEP1245del	NM_203446.2	NP_982271.2	O43426	SYNJ1_HUMAN	synaptojanin 1	1261	Pro-rich.						inositol-polyphosphate 5-phosphatase activity|nucleotide binding|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|RNA binding			breast(1)|cervix(1)|endometrium(13)|kidney(5)|large_intestine(13)|lung(11)|ovary(4)|pancreas(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	57						GGGACAAGAGGCTCTTGCAACCTTTG	0.544													18	249	---	---	---	---					
LRCH2	57631	broad.mit.edu	37	X	114391224	114391224	+	Frame_Shift_Del	DEL	A	A	-			TCGA-55-8096-01A-11D-2238-08	TCGA-55-8096-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	babd96af-bc23-49ee-b8ef-541bc076c7c4	fbc4dd00-fd9b-4988-aa44-ce1598a2150b	g.chrX:114391224delA	ENST00000317135.8	-	12	1500	c.1470delT	c.(1468-1470)ctfs	p.L490fs	LRCH2_ENST00000538422.1_Frame_Shift_Del_p.L490fs	NM_020871.3	NP_065922.3	Q5VUJ6	LRCH2_HUMAN	leucine-rich repeats and calponin homology (CH) domain containing 2	490										breast(1)|endometrium(4)|kidney(3)|large_intestine(3)|lung(6)|ovary(1)|prostate(1)	19						TTGAATGATTAAGAATCCTAG	0.259													2	4	---	---	---	---