Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
APOB	338	broad.mit.edu	37	2	21250797	21250797	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr2:21250797C>A	ENST00000233242.1	-	14	2097	c.1970G>T	c.(1969-1971)gGg>gTg	p.G657V	APOB_ENST00000399256.4_Missense_Mutation_p.G657V	NM_000384.2	NP_000375.2	P04114	APOB_HUMAN	apolipoprotein B	657	Vitellogenin.				cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			NS(5)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(19)|kidney(10)|large_intestine(63)|liver(5)|lung(125)|ovary(16)|pancreas(1)|prostate(5)|skin(31)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(6)	305	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	TATAAGATTCCCTTCTATTTT	0.413000													12	110					0.00185496	0.00193098	0.435327	1	0
TTC37	9652	broad.mit.edu	37	5	94860190	94860190	+	Silent	SNP	C	C	T			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr5:94860190C>T	ENST00000358746.2	-	16	1729	c.1431G>A	c.(1429-1431)aaG>aaA	p.K477K		NM_014639.3	NP_055454.1	Q6PGP7	TTC37_HUMAN	tetratricopeptide repeat domain 37	477							binding			breast(2)|endometrium(6)|kidney(3)|large_intestine(13)|liver(1)|lung(15)|ovary(4)|pancreas(1)|prostate(1)|skin(1)	47						GGGTAAGAGCCTTTGTTTTAT	0.333000													12	51					0	0	0.387290	0	0
CLDN25	644672	broad.mit.edu	37	11	113650992	113650992	+	Silent	SNP	C	C	A			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr11:113650992C>A	ENST00000453129.2	+	1	524	c.475C>A	c.(475-477)Cgg>Agg	p.R159R		NM_001101389.1	NP_001094859.1	C9JDP6	CLD25_HUMAN	claudin 25	159						integral to membrane|tight junction	structural molecule activity			large_intestine(1)|lung(6)|ovary(1)|urinary_tract(2)	10						CATCATACCTCGGTGGGAGTT	0.577000													9	37					3.09899e-07	3.61074e-07	0.307466	1	0
MYOC	4653	broad.mit.edu	37	1	171605171	171605171	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr1:171605171C>T	ENST00000037502.5	-	3	1468	c.1409G>A	c.(1408-1410)cGc>cAc	p.R470H		NM_000261.1	NP_000252.1	Q99972	MYOC_HUMAN	myocilin, trabecular meshwork inducible glucocorticoid response	470	Olfactomedin-like.		R -> C (in GLC1A).|R -> H.		anatomical structure morphogenesis	cilium|extracellular space|rough endoplasmic reticulum	structural molecule activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(4)|lung(12)|ovary(2)|prostate(1)|urinary_tract(2)	28	all_cancers(6;5.47e-10)|all_hematologic(923;0.088)|Acute lymphoblastic leukemia(37;0.181)					GTACTTATAGCGGTTCTTGAA	0.488000													6	114					0	0	0.217242	0	0
TRPM5	29850	broad.mit.edu	37	11	2432639	2432639	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr11:2432639C>T	ENST00000452833.1	-	18	2739	c.2731G>A	c.(2731-2733)Gtg>Atg	p.V911M	TRPM5_ENST00000533060.1_Missense_Mutation_p.V909M|TRPM5_ENST00000528453.1_Missense_Mutation_p.V909M|TRPM5_ENST00000155858.6_Missense_Mutation_p.V909M			Q9NZQ8	TRPM5_HUMAN	transient receptor potential cation channel, subfamily M, member 5	909						integral to membrane|plasma membrane	receptor activity|voltage-gated ion channel activity			breast(1)|central_nervous_system(1)|endometrium(4)|liver(1)|lung(8)|ovary(2)|prostate(2)|skin(2)|urinary_tract(2)	23		Medulloblastoma(188;0.0049)|Breast(177;0.00586)|all_epithelial(84;0.0075)|Ovarian(85;0.0256)|all_neural(188;0.0311)		BRCA - Breast invasive adenocarcinoma(625;0.00147)|LUSC - Lung squamous cell carcinoma(625;0.191)		CGGTAGAGCACCCGGCGGAAG	0.632000													15	30					0	0	0.457914	0	0
SI	6476	broad.mit.edu	37	3	164766974	164766974	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr3:164766974C>A	ENST00000264382.3	-	15	1718	c.1656G>T	c.(1654-1656)tgG>tgT	p.W552C		NM_001041.3	NP_001032.2	P14410	SUIS_HUMAN	sucrase-isomaltase (alpha-glucosidase)	552	Isomaltase.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity	p.W552C(1)		NS(4)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(6)|kidney(10)|large_intestine(18)|lung(124)|ovary(9)|pancreas(1)|prostate(6)|skin(6)|upper_aerodigestive_tract(16)|urinary_tract(1)	218		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	ACTGTTTACCCCAGTTCTGCA	0.338000										HNSCC(35;0.089)			14	55					1.3612e-06	1.56446e-06	0.479597	1	0
LILRB2	10288	broad.mit.edu	37	19	54780767	54780767	+	Silent	SNP	C	C	A			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr19:54780767C>A	ENST00000391748.1	-	10	1501	c.1374G>T	c.(1372-1374)ctG>ctT	p.L458L	LILRB2_ENST00000314446.5_Silent_p.L458L|LILRB2_ENST00000391746.1_Silent_p.L459L|LILRB2_ENST00000391749.4_Silent_p.L459L|LILRB2_ENST00000434421.1_Silent_p.L343L	NM_001278403.1	NP_001265332.1	Q8N423	LIRB2_HUMAN	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2	459					cell surface receptor linked signaling pathway|cell-cell signaling|cellular defense response|immune response|regulation of immune response	integral to plasma membrane|membrane fraction	receptor activity			breast(2)|endometrium(3)|kidney(1)|large_intestine(4)|lung(30)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	44	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		TCACAACCCCCAGGTGCCTTC	0.572000													18	33					3.52763e-06	3.96468e-06	0.520397	1	0
FRG1B	284802	broad.mit.edu	37	20	29625875	29625875	+	Missense_Mutation	SNP	T	T	C	rs143761036	by1000genomes	TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr20:29625875T>C	ENST00000278882.3	+	5	499	c.119T>C	c.(118-120)aTc>aCc	p.I40T	FRG1B_ENST00000439954.2_Missense_Mutation_p.I45T|FRG1B_ENST00000358464.4_Missense_Mutation_p.I40T														p.I40T(4)		endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						ATGTACAGAATCGCCCTGAAA	0.358000													7	99					0	0	0.361761	0	0
MYCBP2	23077	broad.mit.edu	37	13	77670506	77670506	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr13:77670506C>A	ENST00000407578.2	-	57	10161	c.9895G>T	c.(9895-9897)Gta>Tta	p.V3299L	MYCBP2-AS1_ENST00000593933.1_RNA|MYCBP2_ENST00000357337.6_Missense_Mutation_p.V3261L|MYCBP2_ENST00000544440.2_Missense_Mutation_p.V3261L	NM_015057.4	NP_055872.4	O75592	MYCB2_HUMAN	MYC binding protein 2, E3 ubiquitin protein ligase	3261					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ligase activity|protein binding|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(8)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|lung(51)|ovary(5)|pancreas(2)|prostate(5)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	118		Breast(118;0.212)|Acute lymphoblastic leukemia(28;0.22)		GBM - Glioblastoma multiforme(99;0.109)		CGATCACATACCAGATACCAA	0.438000													44	132					2.13384e-23	3.04492e-23	0.870114	1	0
JAKMIP1	152789	broad.mit.edu	37	4	6107526	6107526	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr4:6107526C>A	ENST00000409021.3	-	3	747	c.298G>T	c.(298-300)Gcg>Tcg	p.A100S	JAKMIP1_ENST00000457227.2_Intron|JAKMIP1_ENST00000409831.1_Missense_Mutation_p.A100S|JAKMIP1_ENST00000409371.3_Intron|JAKMIP1_ENST00000410077.2_Intron|JAKMIP1_ENST00000282924.5_Missense_Mutation_p.A100S	NM_001099433.1	NP_001092903.1	Q96N16	JKIP1_HUMAN	janus kinase and microtubule interacting protein 1	100	Mediates association with microtubules.				protein transport	cytoplasm|membrane|microtubule|peripheral to membrane of membrane fraction|ribonucleoprotein complex	GABA receptor binding|RNA binding			NS(2)|endometrium(1)|kidney(2)|large_intestine(10)|lung(13)|ovary(2)|pancreas(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	42						GCGGTGCGCGCCGCCTCCTGC	0.682000													14	31					0.000151284	0.000160779	0.435327	1	0
HIST1H3G	8355	broad.mit.edu	37	6	26271216	26271216	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr6:26271216C>A	ENST00000305910.3	-	1	396	c.397G>T	c.(397-399)Ggg>Tgg	p.G133W		NM_003534.2	NP_003525.1	P68431	H31_HUMAN	histone cluster 1, H3g	133					blood coagulation|nucleosome assembly|regulation of gene silencing|S phase	nucleoplasm|nucleosome	DNA binding|protein binding			breast(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(4)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	12						GCTCTCTCCCCACGAATGCGG	0.493000													17	69					5.03518e-11	6.39468e-11	0.557998	1	0
SHANK1	50944	broad.mit.edu	37	19	51217099	51217099	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr19:51217099C>T	ENST00000293441.1	-	5	766	c.748G>A	c.(748-750)Gca>Aca	p.A250T	SHANK1_ENST00000391814.1_Missense_Mutation_p.A250T|SHANK1_ENST00000359082.3_Missense_Mutation_p.A250T	NM_016148.2	NP_057232.2	Q9Y566	SHAN1_HUMAN	SH3 and multiple ankyrin repeat domains 1	250					cytoskeletal anchoring at plasma membrane	cell junction|cytoplasm|dendrite|membrane fraction|postsynaptic density|postsynaptic membrane	ionotropic glutamate receptor binding			breast(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(15)|liver(1)|lung(21)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)	64		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00493)|GBM - Glioblastoma multiforme(134;0.0199)		TTATGCAGTGCGGTCATGCCA	0.657000													8	69					0	0	0.307466	0	0
DTNA	1837	broad.mit.edu	37	18	32407563	32407563	+	Silent	SNP	C	C	G			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr18:32407563C>G	ENST00000283365.9	+	12	1368	c.1017C>G	c.(1015-1017)ccC>ccG	p.P339P	DTNA_ENST00000348997.5_Silent_p.P336P|DTNA_ENST00000595022.1_Silent_p.P336P|DTNA_ENST00000599844.1_Silent_p.P18P|DTNA_ENST00000269192.7_Silent_p.P18P|DTNA_ENST00000598774.1_Silent_p.P339P|DTNA_ENST00000269190.7_Silent_p.P340P|DTNA_ENST00000597674.1_Silent_p.P18P|DTNA_ENST00000601125.1_Silent_p.P18P|DTNA_ENST00000598142.1_Silent_p.P339P|DTNA_ENST00000598334.1_Silent_p.P336P|DTNA_ENST00000444659.1_Silent_p.P339P|DTNA_ENST00000554864.3_Silent_p.P336P|DTNA_ENST00000591182.1_Silent_p.P18P|DTNA_ENST00000315456.6_Silent_p.P339P|DTNA_ENST00000399121.5_Silent_p.P336P|DTNA_ENST00000399097.3_Silent_p.P18P|DTNA_ENST00000556414.3_Silent_p.P18P|DTNA_ENST00000269191.6_Silent_p.P339P|DTNA_ENST00000597599.1_Silent_p.P336P|DTNA_ENST00000596745.1_Intron|DTNA_ENST00000399113.3_Silent_p.P339P	NM_032975.3	NP_116757.2	Q9Y4J8	DTNA_HUMAN	dystrobrevin, alpha	339					neuromuscular synaptic transmission|signal transduction|striated muscle contraction	cell junction|cytoplasm|synapse	calcium ion binding|protein binding|zinc ion binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(4)|kidney(1)|large_intestine(2)|lung(19)|prostate(1)|upper_aerodigestive_tract(1)	29						TTAGGCCTCCCAGACCTGTAA	0.438000													21	109					0	0	0.639603	0	0
ZNF217	7764	broad.mit.edu	37	20	52199100	52199100	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr20:52199100C>A	ENST00000371471.2	-	2	691	c.266G>T	c.(265-267)cGg>cTg	p.R89L	ZNF217_ENST00000302342.3_Missense_Mutation_p.R89L			O75362	ZN217_HUMAN	zinc finger protein 217	89					negative regulation of transcription, DNA-dependent	histone deacetylase complex	protein binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			NS(1)|breast(3)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(13)|lung(17)|ovary(1)|prostate(4)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	50	all_cancers(1;6.75e-17)|all_epithelial(1;1.76e-18)|Breast(2;3.83e-14)|Lung NSC(4;9.04e-07)|all_lung(4;2.5e-06)|Ovarian(1;0.0398)		BRCA - Breast invasive adenocarcinoma(1;9.88e-17)|Epithelial(1;1.56e-14)|all cancers(1;9.44e-13)|STAD - Stomach adenocarcinoma(23;0.0474)|Colorectal(105;0.198)			GAGGGTAGGCCGGTGTTGCAT	0.463000													40	127					4.32679e-17	5.94057e-17	0.827153	1	0
PITPNM1	9600	broad.mit.edu	37	11	67263770	67263770	+	Silent	SNP	C	C	G			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr11:67263770C>G	ENST00000356404.3	-	15	2421	c.2196G>C	c.(2194-2196)gcG>gcC	p.A732A	PITPNM1_ENST00000534749.1_Silent_p.A732A|PITPNM1_ENST00000436757.2_Silent_p.A731A	NM_001130848.1|NM_004910.2	NP_001124320.1|NP_004901.2	O00562	PITM1_HUMAN	phosphatidylinositol transfer protein, membrane-associated 1	732	DDHD.				brain development|lipid metabolic process|phototransduction|protein transport	cleavage furrow|endoplasmic reticulum membrane|Golgi cisterna membrane|lipid particle|membrane fraction|midbody	metal ion binding|phosphatidylinositol transporter activity			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(2)|liver(1)|lung(4)|ovary(1)|prostate(1)|skin(3)	18						AGGGGTCAGCCGCGTGGAAGA	0.642000													17	51					0	0	0.520397	0	0
OR2M4	26245	broad.mit.edu	37	1	248403107	248403107	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr1:248403107C>G	ENST00000306687.1	+	1	877	c.877C>G	c.(877-879)Cgc>Ggc	p.R293G		NM_017504.1	NP_059974.1	Q96R27	OR2M4_HUMAN	olfactory receptor, family 2, subfamily M, member 4	293					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.R293C(1)		NS(1)|breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(8)|lung(27)|skin(3)|upper_aerodigestive_tract(2)	50	all_cancers(71;0.000124)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			TTATAGCCTCCGCAACAAAGA	0.438000													13	83					0	0	0.479597	0	0
ZNF251	90987	broad.mit.edu	37	8	145948540	145948540	+	Missense_Mutation	SNP	T	T	A			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr8:145948540T>A	ENST00000292562.7	-	5	780	c.505A>T	c.(505-507)Acc>Tcc	p.T169S	ZNF251_ENST00000524394.1_Intron	NM_138367.1	NP_612376.1	Q9BRH9	ZN251_HUMAN	zinc finger protein 251	169					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			autonomic_ganglia(1)|kidney(1)|large_intestine(5)|lung(9)|stomach(1)	17	all_cancers(97;3.54e-11)|all_epithelial(106;2.65e-10)|Lung NSC(106;4.08e-05)|all_lung(105;0.000125)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.75e-39)|Epithelial(56;7.54e-38)|all cancers(56;6.19e-33)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.11)	GBM - Glioblastoma multiforme(99;0.198)		CTGCCCACGGTAGCTTCTGTT	0.448000													26	95					0	0	0.693898	0	0
HERC2	8924	broad.mit.edu	37	15	28460848	28460848	+	Silent	SNP	G	G	A			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr15:28460848G>A	ENST00000261609.7	-	39	6237	c.6129C>T	c.(6127-6129)ctC>ctT	p.L2043L		NM_004667.5	NP_004658.3	O95714	HERC2_HUMAN	HECT and RLD domain containing E3 ubiquitin protein ligase 2	2043					DNA repair|intracellular protein transport|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	guanyl-nucleotide exchange factor activity|heme binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(3)|central_nervous_system(3)|cervix(3)|endometrium(20)|kidney(11)|large_intestine(33)|lung(95)|ovary(7)|prostate(8)|skin(7)|upper_aerodigestive_tract(8)|urinary_tract(4)	204		all_lung(180;1.3e-11)|Breast(32;0.000194)|Colorectal(260;0.227)		all cancers(64;3.93e-09)|Epithelial(43;9.99e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0271)|GBM - Glioblastoma multiforme(186;0.0497)|Lung(196;0.199)		GCGGGGAGCTGAGGGCGCCGC	0.632000													13	26					0	0	0.435327	0	0
MPPED1	758	broad.mit.edu	37	22	43898607	43898607	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr22:43898607C>T	ENST00000417669.1	+	6	1276	c.832C>T	c.(832-834)Cgg>Tgg	p.R278W	MPPED1_ENST00000443721.1_Missense_Mutation_p.R278W|MPPED1_ENST00000439548.1_Missense_Mutation_p.R120W|MPPED1_ENST00000414469.2_Missense_Mutation_p.R172W|MPPED1_ENST00000538182.1_Missense_Mutation_p.R311W|MPPED1_ENST00000542779.1_Missense_Mutation_p.R278W			O15442	MPPD1_HUMAN	metallophosphoesterase domain containing 1	278							hydrolase activity			endometrium(3)|large_intestine(3)|lung(4)|prostate(2)|skin(1)	13		all_neural(38;0.0244)|Ovarian(80;0.0694)				CGTCCAGCCGCGGTTACATGT	0.627000													34	73					0	0	0.812448	0	0
SLC9A2	6549	broad.mit.edu	37	2	103317539	103317539	+	Missense_Mutation	SNP	T	T	C			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr2:103317539T>C	ENST00000233969.2	+	8	1739	c.1597T>C	c.(1597-1599)Ttt>Ctt	p.F533L	SLC9A2_ENST00000469286.1_3'UTR	NM_003048.3	NP_003039.2	Q9UBY0	SL9A2_HUMAN	solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2	533						integral to membrane|plasma membrane	sodium:hydrogen antiporter activity			breast(5)|central_nervous_system(3)|endometrium(3)|kidney(1)|large_intestine(3)|lung(17)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	42						GTTTAAGAAGTTTGATGATAA	0.294000													9	47					0	0	0.307466	0	0
UBB	7314	broad.mit.edu	37	17	16285719	16285719	+	Silent	SNP	T	T	C	rs1060763		TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr17:16285719T>C	ENST00000302182.3	+	2	890	c.498T>C	c.(496-498)acT>acC	p.T166T	UBB_ENST00000578649.1_3'UTR|UBB_ENST00000395837.1_Silent_p.T166T|UBB_ENST00000395839.1_Silent_p.T166T|UBB_ENST00000535788.1_Silent_p.T90T|RP11-138I1.4_ENST00000583934.1_RNA	NM_018955.2	NP_061828.1	P0CG47	UBB_HUMAN	ubiquitin B	166	Ubiquitin-like 3.				activation of MAPK activity|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|anti-apoptosis|apoptosis|cellular membrane organization|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA repair|endosome transport|epidermal growth factor receptor signaling pathway|G1/S transition of mitotic cell cycle|I-kappaB kinase/NF-kappaB cascade|induction of apoptosis by extracellular signals|innate immune response|JNK cascade|M/G1 transition of mitotic cell cycle|mRNA metabolic process|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of type I interferon production|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|S phase of mitotic cell cycle|stress-activated MAPK cascade|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|viral reproduction	cytosol|endocytic vesicle membrane|endosome membrane|nucleoplasm|plasma membrane	protein binding			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(2)|lung(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	16				UCEC - Uterine corpus endometrioid carcinoma (92;0.0822)		AGACCATCACTCTGGAGGTGG	0.552000													3	48					0	0	0.150653	0	0
ZIK1	284307	broad.mit.edu	37	19	58101399	58101399	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr19:58101399G>T	ENST00000597850.1	+	4	435	c.220G>T	c.(220-222)Gat>Tat	p.D74Y	ZIK1_ENST00000536878.2_Missense_Mutation_p.D61Y|ZIK1_ENST00000599456.1_Missense_Mutation_p.D19Y|ZIK1_ENST00000307468.4_Missense_Mutation_p.R18S	NM_001010879.2	NP_001010879.2	Q3SY52	ZIK1_HUMAN	zinc finger protein interacting with K protein 1	74	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(10)|prostate(2)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	34		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0257)		TGGAACAGAGGATGAAGAGAC	0.463000													5	45					0.184627	0.185357	0.184627	1	0
SCP2D1	140856	broad.mit.edu	37	20	18794596	18794596	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr20:18794596C>A	ENST00000377428.2	+	1	227	c.137C>A	c.(136-138)cCa>cAa	p.P46Q	C20orf78_ENST00000278779.4_Intron	NM_178483.2	NP_848578.1			SCP2 sterol-binding domain containing 1																		GAGAGCTTCCCAGTGTTTCAG	0.507000													23	38					2.89027e-11	3.68909e-11	0.624587	1	0
GPR112	139378	broad.mit.edu	37	X	135432398	135432398	+	Missense_Mutation	SNP	T	T	C			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chrX:135432398T>C	ENST00000394143.1	+	6	6824	c.6533T>C	c.(6532-6534)cTt>cCt	p.L2178P	GPR112_ENST00000412101.1_Missense_Mutation_p.L1973P|GPR112_ENST00000394141.1_Missense_Mutation_p.L1973P|GPR112_ENST00000287534.4_Missense_Mutation_p.L2115P|GPR112_ENST00000370652.1_Missense_Mutation_p.L2178P	NM_153834.3	NP_722576.3	Q8IZF6	GP112_HUMAN	G protein-coupled receptor 112	2178					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(2)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(33)|lung(97)|ovary(5)|pancreas(2)|prostate(4)|skin(10)|upper_aerodigestive_tract(1)|urinary_tract(2)	199	Acute lymphoblastic leukemia(192;0.000127)					CTGGACTCCCTTCTAAATATA	0.428000													52	87					0	0	0.870114	0	0
NRG2	9542	broad.mit.edu	37	5	139260463	139260463	+	Silent	SNP	C	C	A	rs111392314		TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr5:139260463C>A	ENST00000541337.1	-	3	1198	c.969G>T	c.(967-969)cgG>cgT	p.R323R	NRG2_ENST00000518130.1_5'UTR|NRG2_ENST00000394770.1_Silent_p.R323R|NRG2_ENST00000358522.3_Silent_p.R323R|NRG2_ENST00000361474.1_Silent_p.R323R|NRG2_ENST00000545385.1_Silent_p.R323R|NRG2_ENST00000289422.7_Silent_p.R323R|NRG2_ENST00000340391.3_Silent_p.R120R|NRG2_ENST00000289409.4_Silent_p.R323R	NM_001184935.1	NP_001171864.1	O14511	NRG2_HUMAN	neuregulin 2	374	Ig-like C2-type.				embryo development	extracellular region|integral to membrane|plasma membrane	growth factor activity			breast(2)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(5)|ovary(1)|pancreas(2)|prostate(1)|skin(1)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(1)	25			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AAAGCCGGCCCCGGACGGTGT	0.637000													26	55					1.66031e-10	2.0981e-10	0.667858	1	0
ZAN	7455	broad.mit.edu	37	7	100348417	100348417	+	RNA	SNP	G	G	C			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr7:100348417G>C	ENST00000542585.1	+	0	1567				ZAN_ENST00000546292.1_RNA|ZAN_ENST00000421100.1_RNA|ZAN_ENST00000449052.1_RNA|ZAN_ENST00000443370.1_RNA|ZAN_ENST00000348028.3_RNA|ZAN_ENST00000546213.1_RNA|ZAN_ENST00000538115.1_RNA|ZAN_ENST00000349350.6_RNA|ZAN_ENST00000427578.1_RNA	NM_003386.1	NP_003377.1	Q9Y493	ZAN_HUMAN	zonadhesin (gene/pseudogene)						binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				NS(2)|breast(3)|central_nervous_system(3)|endometrium(21)|kidney(6)|large_intestine(18)|lung(60)|ovary(4)|pancreas(3)|prostate(5)|skin(8)|stomach(3)|upper_aerodigestive_tract(3)	139	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			GAAGTCCTGCGGGGAGTCCCC	0.622000													8	19					0	0	0.335167	0	0
PRPSAP1	5635	broad.mit.edu	37	17	74328494	74328494	+	Nonsense_Mutation	SNP	C	C	A			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr17:74328494C>A	ENST00000446526.3	-	4	758	c.313G>T	c.(313-315)Gag>Tag	p.E105*	PRPSAP1_ENST00000324684.4_Nonsense_Mutation_p.E2*	NM_002766.2	NP_002757.2	Q14558	KPRA_HUMAN	phosphoribosyl pyrophosphate synthetase-associated protein 1	76					nucleotide biosynthetic process		enzyme inhibitor activity|identical protein binding|magnesium ion binding|ribose phosphate diphosphokinase activity			cervix(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(3)|ovary(1)|skin(1)|urinary_tract(1)	17						ATGAGCAACTCCATCACAGCT	0.428000													22	79					1.28384e-07	1.52381e-07	0.608945	1	0
CIT	11113	broad.mit.edu	37	12	120156087	120156087	+	Silent	SNP	C	C	T			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr12:120156087C>T	ENST00000392521.2	-	32	4186	c.4131G>A	c.(4129-4131)ccG>ccA	p.P1377P	CIT_ENST00000261833.7_Silent_p.P1335P|CIT_ENST00000537607.1_5'UTR	NM_001206999.1	NP_001193928.1	O14578	CTRO_HUMAN	citron (rho-interacting, serine/threonine kinase 21)	1335					intracellular signal transduction		ATP binding|metal ion binding|protein serine/threonine kinase activity|SH3 domain binding|small GTPase regulator activity			breast(6)|endometrium(9)|kidney(4)|large_intestine(15)|liver(1)|lung(29)|ovary(7)|prostate(4)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(6)	86	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)	Myeloproliferative disorder(1001;0.0255)		BRCA - Breast invasive adenocarcinoma(302;0.211)		GGCTGGATGGCGGGGCCAGCA	0.572000													3	45					0	0	0.115264	0	0
ASGR2	433	broad.mit.edu	37	17	7012167	7012167	+	Silent	SNP	G	G	A			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr17:7012167G>A	ENST00000380952.2	-	3	429	c.165C>T	c.(163-165)tcC>tcT	p.S55S	ASGR2_ENST00000446679.2_Silent_p.S36S|ASGR2_ENST00000254850.7_Silent_p.S36S|ASGR2_ENST00000355035.5_Silent_p.S55S	NM_001181.4|NM_001201352.1|NM_080912.3	NP_001172.1|NP_001188281.1|NP_550434.1	P07307	ASGR2_HUMAN	asialoglycoprotein receptor 2	55					cell surface receptor linked signaling pathway|endocytosis	focal adhesion|integral to membrane|nucleolus	asialoglycoprotein receptor activity|protein binding|sugar binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(3)|ovary(1)|skin(3)|stomach(4)	18					Antihemophilic Factor(DB00025)	AGCAGACCATGGAGCAGAGAC	0.647000													6	3					0	0	0.217242	0	0
ELP5	23587	broad.mit.edu	37	17	7155866	7155866	+	Silent	SNP	G	G	A			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr17:7155866G>A	ENST00000574993.1	+	1	262	c.45G>A	c.(43-45)ttG>ttA	p.L15L	ELP5_ENST00000396627.2_Silent_p.L15L|ELP5_ENST00000396628.2_Silent_p.L15L|RP1-4G17.5_ENST00000577138.1_Intron|ELP5_ENST00000574255.1_Silent_p.L15L|ELP5_ENST00000573657.1_Silent_p.L15L|ELP5_ENST00000354429.2_Silent_p.L15L|ELP5_ENST00000356683.2_Silent_p.L15L					elongator acetyltransferase complex subunit 5																		GACGCGAGTTGGAGATGTTGG	0.701000													7	15					0	0	0.278610	0	0
KLHL9	55958	broad.mit.edu	37	9	21334009	21334009	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr9:21334009G>C	ENST00000359039.4	-	1	1370	c.850C>G	c.(850-852)Cca>Gca	p.P284A	KLHL9_ENST00000537938.1_Missense_Mutation_p.P216A			Q9P2J3	KLHL9_HUMAN	kelch-like family member 9	284					cytokinesis|mitosis|protein ubiquitination	Cul3-RING ubiquitin ligase complex|midbody				endometrium(9)|large_intestine(7)|lung(10)|ovary(4)|skin(2)	32				Lung(24;8.52e-27)|LUSC - Lung squamous cell carcinoma(38;1.4e-13)|OV - Ovarian serous cystadenocarcinoma(39;0.118)		TGCATCACTGGCTGCATATAT	0.423000													29	68					0	0	0.717897	0	0
UGT1A9	54600	broad.mit.edu	37	2	234580839	234580839	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr2:234580839G>C	ENST00000354728.4	+	1	341	c.259G>C	c.(259-261)Gac>Cac	p.D87H	UGT1A10_ENST00000373445.1_Intron|UGT1A8_ENST00000373450.4_Intron|UGT1A10_ENST00000344644.5_Intron	NM_021027.2	NP_066307.1														breast(2)|endometrium(3)|kidney(3)|large_intestine(9)|lung(14)|ovary(3)|skin(2)|upper_aerodigestive_tract(1)	37		Breast(86;0.000766)|all_lung(227;0.00269)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0331)|Lung NSC(271;0.0459)|Lung SC(224;0.128)		Epithelial(121;1.26e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000436)|Lung(119;0.00347)|LUSC - Lung squamous cell carcinoma(224;0.00757)		GGAGGATCTGGACCGGGAGTT	0.418000													40	55					0	0	0.819951	0	0
BAZ2B	29994	broad.mit.edu	37	2	160189181	160189181	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr2:160189181C>T	ENST00000392783.2	-	34	6308	c.5813G>A	c.(5812-5814)cGa>cAa	p.R1938Q	BAZ2B_ENST00000392782.1_Missense_Mutation_p.R1902Q|BAZ2B_ENST00000355831.2_Missense_Mutation_p.R1904Q|BAZ2B_ENST00000343439.5_Missense_Mutation_p.R1838Q	NM_013450.2	NP_038478.2	Q9UIF8	BAZ2B_HUMAN	bromodomain adjacent to zinc finger domain, 2B	1938					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(7)|liver(2)|lung(41)|ovary(3)|prostate(1)|skin(2)|soft_tissue(1)|urinary_tract(1)	82						ATCTCCCTTTCGACAGATTTG	0.368000													23	66					0	0	0.667858	0	0
PDE9A	5152	broad.mit.edu	37	21	44182290	44182290	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr21:44182290G>A	ENST00000291539.6	+	14	1243	c.1183G>A	c.(1183-1185)Gag>Aag	p.E395K	PDE9A_ENST00000328862.6_Missense_Mutation_p.E369K|PDE9A_ENST00000398236.3_Missense_Mutation_p.E309K|PDE9A_ENST00000335512.4_Missense_Mutation_p.E335K|PDE9A_ENST00000398225.3_Missense_Mutation_p.E354K|PDE9A_ENST00000398232.3_Missense_Mutation_p.E328K|PDE9A_ENST00000398234.3_Missense_Mutation_p.E294K|PDE9A_ENST00000349112.3_Missense_Mutation_p.E267K|PDE9A_ENST00000470987.1_3'UTR|PDE9A_ENST00000398227.3_Missense_Mutation_p.E235K|PDE9A_ENST00000398229.3_Missense_Mutation_p.E261K|PDE9A_ENST00000539837.1_Missense_Mutation_p.E267K|PDE9A_ENST00000380328.2_Missense_Mutation_p.E342K|PDE9A_ENST00000398224.3_Missense_Mutation_p.E268K|PDE9A_ENST00000335440.6_Missense_Mutation_p.E293K	NM_002606.2	NP_002597.1	O76083	PDE9A_HUMAN	phosphodiesterase 9A	395	Catalytic (By similarity).				platelet activation|signal transduction	cytosol|endoplasmic reticulum|Golgi apparatus|perinuclear region of cytoplasm|ruffle membrane	3',5'-cyclic-GMP phosphodiesterase activity|metal ion binding|protein binding	p.E395K(1)		breast(1)|endometrium(4)|large_intestine(6)|lung(8)|ovary(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	27						GATCCTCGCCGAGCCTGAGTG	0.612000													18	89					0	0	0.520397	0	0
PCNT	5116	broad.mit.edu	37	21	47769710	47769710	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr21:47769710G>C	ENST00000359568.5	+	8	1427	c.1320G>C	c.(1318-1320)gaG>gaC	p.E440D	PCNT_ENST00000480896.1_3'UTR	NM_006031.5	NP_006022.3	O95613	PCNT_HUMAN	pericentrin	440	Glu-rich.				cilium assembly|G2/M transition of mitotic cell cycle	cytosol|microtubule	calmodulin binding			NS(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(15)|liver(2)|lung(41)|ovary(5)|pancreas(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	104	Breast(49;0.112)					AGTTCAAAGAGAGCGAGAAAG	0.443000													18	132					0	0	0.520397	0	0
IL16	3603	broad.mit.edu	37	15	81575082	81575082	+	Missense_Mutation	SNP	T	T	A			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr15:81575082T>A	ENST00000394660.2	+	9	1544	c.1184T>A	c.(1183-1185)cTg>cAg	p.L395Q	IL16_ENST00000302987.4_Missense_Mutation_p.L395Q	NM_001172128.1|NM_172217.3	NP_001165599.1|NP_757366.2	Q14005	IL16_HUMAN	interleukin 16	395	Interaction with GRIN2A.|PDZ 2.				immune response|interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|extracellular space|nucleus|plasma membrane	cytokine activity			NS(1)|autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(5)|large_intestine(12)|lung(20)|ovary(3)|skin(3)|stomach(1)|urinary_tract(1)	57						GTGGCGCACCTGGACGGACGT	0.547000													43	207					0	0	0.870114	0	0
C10orf2	56652	broad.mit.edu	37	10	102753043	102753043	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr10:102753043G>T	ENST00000311916.2	+	5	2016	c.1831G>T	c.(1831-1833)Gat>Tat	p.D611Y	C10orf2_ENST00000370228.1_3'UTR|C10orf2_ENST00000473656.1_3'UTR	NM_001163813.1|NM_021830.4	NP_001157285.1|NP_068602.2	Q96RR1	PEO1_HUMAN	chromosome 10 open reading frame 2	611	SF4 helicase.				cell death|mitochondrial DNA replication|protein hexamerization|protein homooligomerization|transcription from mitochondrial promoter	mitochondrial nucleoid	5'-3' DNA helicase activity|ATP binding|protease binding|single-stranded DNA binding			breast(3)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(10)|ovary(1)|skin(1)|stomach(1)	24		Colorectal(252;0.122)|all_hematologic(284;0.152)		Epithelial(162;7.18e-11)|all cancers(201;8.75e-09)|BRCA - Breast invasive adenocarcinoma(275;0.224)		GAACCGCTTTGATGGAGATGT	0.527000													48	140					6.4308e-24	9.22838e-24	0.870114	1	0
FBXW7	55294	broad.mit.edu	37	4	153332619	153332619	+	Nonsense_Mutation	SNP	C	C	A			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr4:153332619C>A	ENST00000281708.4	-	2	1566	c.337G>T	c.(337-339)Gag>Tag	p.E113*	FBXW7_ENST00000603548.1_Nonsense_Mutation_p.E113*|FBXW7_ENST00000603841.1_Nonsense_Mutation_p.E113*|FBXW7_ENST00000604872.1_Nonsense_Mutation_p.E113*	NM_033632.3	NP_361014.1	Q969H0	FBXW7_HUMAN	F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase	113					interspecies interaction between organisms|lipid homeostasis|negative regulation of DNA endoreduplication|negative regulation of hepatocyte proliferation|negative regulation of Notch signaling pathway|negative regulation of triglyceride biosynthetic process|positive regulation of epidermal growth factor receptor activity|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein stabilization|protein ubiquitination|regulation of lipid storage|regulation of protein localization|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|sister chromatid cohesion|vasculature development	nucleolus|nucleoplasm|SCF ubiquitin ligase complex	protein binding			NS(1)|biliary_tract(8)|bone(1)|breast(5)|central_nervous_system(6)|cervix(2)|endometrium(36)|haematopoietic_and_lymphoid_tissue(159)|kidney(6)|large_intestine(155)|lung(31)|ovary(10)|pancreas(3)|prostate(2)|skin(6)|stomach(16)|upper_aerodigestive_tract(9)|urinary_tract(6)	462	all_hematologic(180;0.093)	Acute lymphoblastic leukemia(8;0.000629)|all_hematologic(8;0.067)				tcctcctcctcatcctcctcA	0.423000			"""Mis, N, D, F"""		"""colorectal, endometrial, T-ALL"""								20	70					4.96729e-08	6.00806e-08	0.575678	1	0
ZNF676	163223	broad.mit.edu	37	19	22363587	22363587	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr19:22363587C>G	ENST00000397121.2	-	3	1249	c.932G>C	c.(931-933)tGt>tCt	p.C311S		NM_001001411.2	NP_001001411.2	Q8N7Q3	ZN676_HUMAN	zinc finger protein 676	311					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(49)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(2)	67		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.114)				ACATTCTTCACACTTGTAGGG	0.443000													5	99					0	0	0.278610	0	0
KRT74	121391	broad.mit.edu	37	12	52962144	52962144	+	Silent	SNP	G	G	A			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr12:52962144G>A	ENST00000549343.1	-	8	1244	c.1206C>T	c.(1204-1206)gaC>gaT	p.D402D	KRT74_ENST00000305620.2_Silent_p.D388D			Q7RTS7	K2C74_HUMAN	keratin 74	388	Coil 2.|Rod.					keratin filament	structural molecule activity			kidney(2)|large_intestine(6)|lung(11)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	28				BRCA - Breast invasive adenocarcinoma(357;0.191)		GCTGCTCAGCGTCAGCGATGG	0.577000													5	34					0	0	0.184627	0	0
PPP1R17	10842	broad.mit.edu	37	7	31732113	31732113	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr7:31732113C>A	ENST00000342032.3	+	2	686	c.58C>A	c.(58-60)Cta>Ata	p.L20I	PPP1R17_ENST00000409146.3_Missense_Mutation_p.L20I	NM_006658.4	NP_006649.2	O96001	GSUB_HUMAN	protein phosphatase 1, regulatory subunit 17	20					behavior|central nervous system development|intracellular protein kinase cascade|protein phosphorylation	soluble fraction											ACTGGACAAGCTAGACCCTCG	0.488000													18	37					9.16793e-09	1.12495e-08	0.520397	1	0
CHRFAM7A	89832	broad.mit.edu	37	15	30664536	30664536	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr15:30664536C>A	ENST00000397827.3	-	6	838	c.64G>T	c.(64-66)Ggc>Tgc	p.G22C	CHRFAM7A_ENST00000299847.2_Missense_Mutation_p.G113C|CHRFAM7A_ENST00000401522.3_Missense_Mutation_p.G22C	NM_148911.1	NP_683709.1	Q494W8	CRFM7_HUMAN	CHRNA7 (cholinergic receptor, nicotinic, alpha 7, exons 5-10) and FAM7A (family with sequence similarity 7A, exons A-E) fusion	113						integral to membrane|postsynaptic membrane	extracellular ligand-gated ion channel activity			large_intestine(3)|lung(1)|skin(2)	6		all_lung(180;3.42e-11)|Breast(32;0.000153)		all cancers(64;1.9e-15)|Epithelial(43;3.59e-12)|GBM - Glioblastoma multiforme(186;9e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00177)|Lung(196;0.153)		CTCCTCTTGCCGGGGATTCCT	0.488000													5	11					2.74318e-10	3.44934e-10	0.335167	1	0
CTTNBP2	83992	broad.mit.edu	37	7	117417623	117417623	+	Missense_Mutation	SNP	T	T	A			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr7:117417623T>A	ENST00000160373.3	-	8	2811	c.2720A>T	c.(2719-2721)aAc>aTc	p.N907I		NM_033427.2	NP_219499.1	Q8WZ74	CTTB2_HUMAN	cortactin binding protein 2	907										breast(3)|central_nervous_system(3)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(36)|ovary(4)|prostate(5)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	83	Lung NSC(10;0.0018)|all_lung(10;0.002)			LUSC - Lung squamous cell carcinoma(290;0.133)		GTTGGCGTGGTTAATGAGGTC	0.498000													16	57					0	0	0.592651	0	0
KIAA1462	57608	broad.mit.edu	37	10	30318595	30318595	+	Missense_Mutation	SNP	T	T	G	rs146919048	by1000genomes	TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr10:30318595T>G	ENST00000375377.1	-	3	583	c.482A>C	c.(481-483)gAg>gCg	p.E161A		NM_020848.2	NP_065899.1	Q9P266	K1462_HUMAN	KIAA1462	161										breast(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(17)|lung(23)|ovary(6)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)	75						CATCACATGCTCTGACCTTCC	0.567000													11	310					0	0	0.361761	0	0
SFXN5	94097	broad.mit.edu	37	2	73172187	73172187	+	Silent	SNP	C	C	A	rs147845998		TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr2:73172187C>A	ENST00000272433.2	-	14	1117	c.987G>T	c.(985-987)acG>acT	p.T329T	SFXN5_ENST00000410065.1_3'UTR|SFXN5_ENST00000474528.1_5'UTR	NM_144579.2	NP_653180.1	Q8TD22	SFXN5_HUMAN	sideroflexin 5	329					iron ion homeostasis	integral to membrane	cation transmembrane transporter activity			breast(1)|cervix(1)|endometrium(1)|large_intestine(2)|lung(1)|ovary(2)|prostate(1)	9						TCCGGCTGCTCGTGGCCTGGG	0.602000													8	22					3.09899e-07	3.61074e-07	0.307466	1	0
LRRC8E	80131	broad.mit.edu	37	19	7963879	7963879	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr19:7963879G>A	ENST00000306708.6	+	3	573	c.472G>A	c.(472-474)Gac>Aac	p.D158N	AC010336.1_ENST00000539278.1_3'UTR	NM_001268284.1|NM_001268285.1|NM_025061.4	NP_001255213.1|NP_001255214.1|NP_079337.2	Q6NSJ5	LRC8E_HUMAN	leucine rich repeat containing 8 family, member E	158						integral to membrane				breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(10)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(10)	35						CAAGTGTTTCGACTCTCCATG	0.577000													6	121					0	0	0.217242	0	0
PCNX	22990	broad.mit.edu	37	14	71485796	71485796	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr14:71485796C>G	ENST00000304743.2	+	12	3513	c.3067C>G	c.(3067-3069)Ctt>Gtt	p.L1023V	PCNX_ENST00000439984.3_Missense_Mutation_p.L912V|PCNX_ENST00000238570.5_Missense_Mutation_p.L1023V	NM_014982.2	NP_055797.2	Q96RV3	PCX1_HUMAN	pecanex homolog (Drosophila)	1023						integral to membrane				NS(2)|biliary_tract(1)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(14)|liver(2)|lung(40)|ovary(1)|prostate(7)|skin(2)|urinary_tract(1)	87			KIRC - Kidney renal clear cell carcinoma(12;0.206)	all cancers(60;0.00835)|BRCA - Breast invasive adenocarcinoma(234;0.00951)|OV - Ovarian serous cystadenocarcinoma(108;0.0417)		GGGATCTATTCTTCTCATACA	0.433000													41	121					0	0	0.834066	0	0
GON4L	54856	broad.mit.edu	37	1	155735478	155735478	+	Silent	SNP	G	G	A			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr1:155735478G>A	ENST00000437809.1	-	21	3908	c.3786C>T	c.(3784-3786)ttC>ttT	p.F1262F	GON4L_ENST00000368331.1_Silent_p.F1262F|GON4L_ENST00000361040.5_Silent_p.F1262F|GON4L_ENST00000271883.5_Silent_p.F1262F|GON4L_ENST00000471341.1_5'UTR			Q3T8J9	GON4L_HUMAN	gon-4-like (C. elegans)	1262					regulation of transcription, DNA-dependent	cytoplasm|nucleus	DNA binding			NS(2)|breast(4)|cervix(1)|endometrium(7)|kidney(4)|large_intestine(7)|lung(10)|ovary(3)|prostate(3)|skin(2)|stomach(1)|urinary_tract(1)	45	Hepatocellular(266;0.0997)|all_hematologic(923;0.145)|all_neural(408;0.195)					CCACTTTCGGGAAAACAGTAG	0.512000													9	110					0	0	0.307466	0	0
PCSK7	9159	broad.mit.edu	37	11	117100519	117100519	+	Silent	SNP	G	G	A			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr11:117100519G>A	ENST00000320934.3	-	3	672	c.42C>T	c.(40-42)ccC>ccT	p.P14P		NM_004716.2	NP_004707.2	Q16549	PCSK7_HUMAN	proprotein convertase subtilisin/kexin type 7	14					peptide hormone processing	integral to Golgi membrane	serine-type endopeptidase activity			NS(1)|endometrium(3)|large_intestine(2)|lung(8)|ovary(1)|skin(1)	16	all_hematologic(175;0.0487)	Breast(348;0.00908)|Medulloblastoma(222;0.0425)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;1.72e-06)|Epithelial(105;6.71e-05)|all cancers(92;0.000537)		GCAGGCCCAGGGGGGCATCCA	0.587000			T	IGH@	MLCLS								3	21					0	0	0.115264	0	0
NKAIN3	286183	broad.mit.edu	37	8	63492112	63492112	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr8:63492112G>C	ENST00000523211.1	+	2	201	c.69G>C	c.(67-69)gaG>gaC	p.E23D	NKAIN3_ENST00000328472.5_Missense_Mutation_p.E23D|NKAIN3_ENST00000519049.1_3'UTR	NM_173688.2	NP_775959.1	Q8N8D7	NKAI3_HUMAN	Na+/K+ transporting ATPase interacting 3	23						integral to membrane|plasma membrane				kidney(3)|large_intestine(2)|lung(8)	13	Breast(64;0.127)	Lung NSC(129;0.187)				CAGCATTAGAGAGGCAGATCT	0.383000													6	162					0	0	0.248553	0	0
TSR1	55720	broad.mit.edu	37	17	2239378	2239378	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr17:2239378C>A	ENST00000301364.4	-	2	1233	c.154G>T	c.(154-156)Gac>Tac	p.D52Y		NM_018128.4	NP_060598.3	Q2NL82	TSR1_HUMAN	TSR1, 20S rRNA accumulation, homolog (S. cerevisiae)	52					ribosome assembly	nucleolus	protein binding			autonomic_ganglia(1)|breast(2)|endometrium(1)|kidney(2)|large_intestine(7)|lung(4)|ovary(1)|prostate(1)|urinary_tract(1)	20						TGCCTCTGGTCGACTCTGCTG	0.567000													31	87					7.63091e-17	1.04207e-16	0.834066	1	0
ZNF532	55205	broad.mit.edu	37	18	56651465	56651465	+	Missense_Mutation	SNP	G	G	A	rs142104041		TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr18:56651465G>A	ENST00000336078.4	+	11	4449	c.3673G>A	c.(3673-3675)Gta>Ata	p.V1225I	ZNF532_ENST00000591808.1_Missense_Mutation_p.V1225I|ZNF532_ENST00000588956.1_3'UTR|ZNF532_ENST00000589288.1_Missense_Mutation_p.V1225I|ZNF532_ENST00000591230.1_Missense_Mutation_p.V1225I|ZNF532_ENST00000591083.1_Missense_Mutation_p.V1225I	NM_018181.4	NP_060651.2	Q9HCE3	ZN532_HUMAN	zinc finger protein 532	1225					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(5)|central_nervous_system(1)|cervix(2)|endometrium(14)|kidney(1)|large_intestine(9)|lung(14)|prostate(1)|skin(4)|urinary_tract(1)	52						CCTCTTCATCGTACACAAGTT	0.532000													11	38					0	0	0.411799	0	0
ZNF382	84911	broad.mit.edu	37	19	37100919	37100919	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr19:37100919G>T	ENST00000435416.1	+	1	1598	c.103G>T	c.(103-105)Gtg>Ttg	p.V35L	ZNF382_ENST00000423582.1_Intron|ZNF382_ENST00000292928.2_Missense_Mutation_p.V35L|ZNF382_ENST00000439428.1_Missense_Mutation_p.V34L			Q96SR6	ZN382_HUMAN	zinc finger protein 382	35	KRAB.|Mediates interaction with TRIM28 (By similarity).|Represses transcription (By similarity).				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(12)|lung(9)|prostate(2)|skin(2)|upper_aerodigestive_tract(4)	34	Esophageal squamous(110;0.198)		COAD - Colon adenocarcinoma(19;0.0454)|Colorectal(19;0.065)			TTACAGGGATGTGATGTTGGA	0.463000													16	72					2.31682e-05	2.49353e-05	0.479597	1	0
EYA1	2138	broad.mit.edu	37	8	72127907	72127907	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr8:72127907C>A	ENST00000340726.3	-	15	2056	c.1417G>T	c.(1417-1419)Gcc>Tcc	p.A473S	EYA1_ENST00000388742.4_Missense_Mutation_p.A473S|EYA1_ENST00000388740.3_Missense_Mutation_p.A440S|EYA1_ENST00000388741.2_Missense_Mutation_p.A439S|EYA1_ENST00000303824.7_Missense_Mutation_p.A467S|EYA1_ENST00000419131.1_Missense_Mutation_p.A438S|EYA1_ENST00000388743.2_Missense_Mutation_p.A472S	NM_000503.4	NP_000494.2	Q99502	EYA1_HUMAN	eyes absent homolog 1 (Drosophila)	473					double-strand break repair|histone dephosphorylation|positive regulation of DNA repair|protein sumoylation|regulation of transcription, DNA-dependent|response to ionizing radiation|sensory perception of sound|transcription, DNA-dependent	cytoplasm|nucleus	metal ion binding|protein tyrosine phosphatase activity			NS(2)|breast(3)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(8)|lung(15)|ovary(4)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	44	Breast(64;0.046)		Epithelial(68;0.0837)|all cancers(69;0.247)			TCGGTCAGGGCTTCAATTTCG	0.542000													22	79					1.50039e-11	1.92474e-11	0.608945	1	0
SHC4	399694	broad.mit.edu	37	15	49255125	49255125	+	Missense_Mutation	SNP	A	A	G			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr15:49255125A>G	ENST00000332408.4	-	1	516	c.88T>C	c.(88-90)Tac>Cac	p.Y30H		NM_203349.3	NP_976224.3	Q6S5L8	SHC4_HUMAN	SHC (Src homology 2 domain containing) family, member 4	30	CH2.				intracellular signal transduction	cell junction|postsynaptic membrane				breast(1)|endometrium(2)|large_intestine(8)|lung(11)|ovary(3)|pancreas(2)|skin(1)|upper_aerodigestive_tract(1)	29		all_lung(180;0.00466)		all cancers(107;9.4e-08)|GBM - Glioblastoma multiforme(94;5.94e-07)		AAGCGGCTGTACTTGGCCCTG	0.652000													36	86					0	0	0.834066	0	0
LGR5	8549	broad.mit.edu	37	12	71946940	71946940	+	Missense_Mutation	SNP	T	T	G			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr12:71946940T>G	ENST00000266674.5	+	5	827	c.516T>G	c.(514-516)aaT>aaG	p.N172K	LGR5_ENST00000540815.2_Missense_Mutation_p.N172K|LGR5_ENST00000536515.1_Intron			O75473	LGR5_HUMAN	leucine-rich repeat containing G protein-coupled receptor 5	172						integral to plasma membrane	protein-hormone receptor activity		NUP107/LGR5(2)	endometrium(2)|kidney(3)|large_intestine(2)|lung(24)|ovary(1)|pancreas(2)|prostate(1)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(3)	48						TGGATGACAATGCGTTAACAG	0.507000													14	89					0	0	0.457914	0	0
ASXL3	80816	broad.mit.edu	37	18	31318469	31318469	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr18:31318469G>T	ENST00000269197.5	+	11	1101	c.1101G>T	c.(1099-1101)gaG>gaT	p.E367D		NM_030632.1	NP_085135.1	Q9C0F0	ASXL3_HUMAN	additional sex combs like 3 (Drosophila)	367					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding			breast(3)|endometrium(3)|kidney(3)|large_intestine(6)|lung(22)|ovary(2)|pancreas(1)|skin(2)|urinary_tract(1)	43						TGTCAAGAGAGGAATCTGTGA	0.433000													7	11					0.00307968	0.00317983	0.278610	1	0
DPY19L3	147991	broad.mit.edu	37	19	32923654	32923654	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr19:32923654G>C	ENST00000342179.5	+	4	485	c.270G>C	c.(268-270)gaG>gaC	p.E90D	DPY19L3_ENST00000392250.2_Missense_Mutation_p.E90D|DPY19L3_ENST00000586987.1_Missense_Mutation_p.E90D	NM_207325.2	NP_997208.2	Q6ZPD9	D19L3_HUMAN	dpy-19-like 3 (C. elegans)	90						integral to membrane				breast(1)|endometrium(1)|kidney(3)|large_intestine(5)|lung(17)|ovary(4)|pancreas(1)	32	Esophageal squamous(110;0.162)					TCAGAACAGAGTGTGGCCTGT	0.408000													15	60					0	0	0.557998	0	0
CPQ	10404	broad.mit.edu	37	8	97797153	97797153	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr8:97797153G>T	ENST00000220763.5	+	2	238	c.28G>T	c.(28-30)Ggt>Tgt	p.G10C		NM_016134.2	NP_057218.1	Q9Y646	PGCP_HUMAN	carboxypeptidase Q	10					peptide metabolic process|proteolysis	cytoplasm|extracellular space	metal ion binding|metallocarboxypeptidase activity										CGCATTTTTCGGTGGTGTTCA	0.338000													20	127					2.4624e-09	3.05097e-09	0.575678	1	0
CDH22	64405	broad.mit.edu	37	20	44839089	44839089	+	Silent	SNP	C	C	G			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr20:44839089C>G	ENST00000372262.3	-	6	1543	c.1143G>C	c.(1141-1143)gtG>gtC	p.V381V	CDH22_ENST00000537909.1_Silent_p.V381V|CDH22_ENST00000474438.1_5'UTR	NM_021248.1	NP_067071.1	Q9UJ99	CAD22_HUMAN	cadherin 22, type 2	381	Cadherin 3.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			endometrium(3)|kidney(1)|large_intestine(9)|lung(16)|ovary(4)|pancreas(1)|prostate(3)|skin(4)|urinary_tract(3)	44		Myeloproliferative disorder(115;0.0122)				CGGCCACGCGCACGATCGCCT	0.716000													3	14					0	0	0.115264	0	0
DNAH5	1767	broad.mit.edu	37	5	13701495	13701495	+	Silent	SNP	T	T	C			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr5:13701495T>C	ENST00000265104.4	-	77	13493	c.13389A>G	c.(13387-13389)gaA>gaG	p.E4463E		NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	4463					microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					GGCTGTTTCTTTCTATAAGTT	0.398000									Kartagener syndrome				12	113					0	0	0.557998	0	0
TAS2R41	259287	broad.mit.edu	37	7	143175434	143175434	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr7:143175434C>G	ENST00000408916.1	+	1	469	c.469C>G	c.(469-471)Caa>Gaa	p.Q157E	EPHA1-AS1_ENST00000429289.1_RNA	NM_176883.2	NP_795364.2	P59536	T2R41_HUMAN	taste receptor, type 2, member 41	157					sensory perception of taste	integral to membrane	G-protein coupled receptor activity			endometrium(2)|large_intestine(2)|lung(10)|pancreas(1)|prostate(2)|skin(1)	18	Melanoma(164;0.15)					CCCTGTATATCAAGAATTTTT	0.443000													12	46					0	0	0.435327	0	0
ABCC2	1244	broad.mit.edu	37	10	101564028	101564028	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr10:101564028C>G	ENST00000370449.4	+	10	1575	c.1462C>G	c.(1462-1464)Cag>Gag	p.Q488E		NM_000392.3	NP_000383.1	Q92887	MRP2_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 2	488	ABC transmembrane type-1 1.					apical plasma membrane|integral to plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|organic anion transmembrane transporter activity			NS(1)|breast(5)|endometrium(9)|kidney(2)|large_intestine(20)|liver(1)|lung(20)|ovary(2)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	67		Colorectal(252;0.234)		Epithelial(162;2.77e-10)|all cancers(201;2.47e-08)	Adenosine triphosphate(DB00171)|Norgestimate(DB00957)|Pravastatin(DB00175)|Saquinavir(DB01232)|Sulfinpyrazone(DB01138)	TAAGACCATTCAGGTAAAGAA	0.418000													26	59					0	0	0.667858	0	0
KRAS	3845	broad.mit.edu	37	12	25398285	25398285	+	Missense_Mutation	SNP	C	C	A	rs121913530		TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr12:25398285C>A	ENST00000311936.3	-	2	225	c.34G>T	c.(34-36)Ggt>Tgt	p.G12C	KRAS_ENST00000557334.1_Missense_Mutation_p.G12C|KRAS_ENST00000256078.4_Missense_Mutation_p.G12C|KRAS_ENST00000556131.1_Missense_Mutation_p.G12C	NM_004985.3	NP_004976.2	P01116	RASK_HUMAN	Kirsten rat sarcoma viral oncogene homolog	12			G -> A (in a colorectal cancer sample; somatic mutation).|G -> C (in lung carcinoma; somatic mutation).|G -> D (in pancreatic carcinoma, GASC and lung carcinoma; somatic mutation).|G -> R (in lung cancer and bladder cancer; somatic mutation).|G -> S (in lung carcinoma and GASC; somatic mutation).|G -> V (in lung carcinoma, pancreatic carcinoma, colon cancer and GASC; somatic mutation).		activation of MAPKK activity|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	plasma membrane	GTP binding|GTPase activity|protein binding	p.G12C(3001)|p.G12S(1288)|p.G12R(789)|p.G12F(46)|p.G12L(8)|p.G12I(4)|p.G12W(3)|p.A11_G12insGA(2)|p.G12Y(2)|p.G12N(1)	UBE2L3/KRAS(2)	NS(6)|adrenal_gland(1)|autonomic_ganglia(3)|biliary_tract(532)|bone(2)|breast(32)|central_nervous_system(14)|cervix(50)|endometrium(411)|eye(4)|gastrointestinal_tract_(site_indeterminate)(7)|genital_tract(1)|haematopoietic_and_lymphoid_tissue(385)|kidney(8)|large_intestine(15267)|liver(29)|lung(3407)|oesophagus(16)|ovary(612)|pancreas(3739)|penis(1)|peritoneum(6)|prostate(96)|salivary_gland(6)|skin(45)|small_intestine(68)|soft_tissue(88)|stomach(207)|testis(17)|thymus(5)|thyroid(159)|upper_aerodigestive_tract(68)|urinary_tract(57)	25349	all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)		OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)			CCTACGCCACCAGCTCCAACT	0.348000	G12C(CALU1_LUNG)|G12C(HCC44_LUNG)|G12C(IALM_LUNG)|G12C(KHM1B_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12C(KYSE410_OESOPHAGUS)|G12C(LU65_LUNG)|G12C(LU99_LUNG)|G12C(MIAPACA2_PANCREAS)|G12C(NCIH1373_LUNG)|G12C(NCIH1792_LUNG)|G12C(NCIH2030_LUNG)|G12C(NCIH2122_LUNG)|G12C(NCIH23_LUNG)|G12C(NCIH358_LUNG)|G12C(OV56_OVARY)|G12C(SW1463_LARGE_INTESTINE)|G12C(SW1573_LUNG)|G12C(SW837_LARGE_INTESTINE)|G12C(UMUC3_URINARY_TRACT)|G12R(CAL62_THYROID)|G12R(HS274T_BREAST)|G12R(HUPT3_PANCREAS)|G12R(KP2_PANCREAS)|G12R(PSN1_PANCREAS)|G12R(TCCPAN2_PANCREAS)|G12S(A549_LUNG)|G12S(KMS20_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12S(LS123_LARGE_INTESTINE)	119	Mis		"""pancreatic, colorectal, lung, thyroid, AML, others"""				Noonan syndrome;Cardiofaciocutaneous syndrome	TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)			10	12					2.17888e-05	2.35504e-05	0.335167	1	0
KIR3DX1	90011	broad.mit.edu	37	19	55044043	55044043	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr19:55044043G>T	ENST00000335056.3	+	1	67	c.29G>T	c.(28-30)tGt>tTt	p.C10F																	endometrium(1)|kidney(2)|large_intestine(4)|lung(14)|ovary(1)|pancreas(1)|skin(1)	24				GBM - Glioblastoma multiforme(193;0.099)		ACCGTCCTGTGTCTGGGTAAG	0.537000													36	124					9.8876e-21	1.40304e-20	0.804634	1	0
OR5I1	10798	broad.mit.edu	37	11	55703583	55703583	+	Silent	SNP	C	C	A			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr11:55703583C>A	ENST00000301532.3	-	1	293	c.294G>T	c.(292-294)ggG>ggT	p.G98G		NM_006637.1	NP_006628.1	Q13606	OR5I1_HUMAN	olfactory receptor, family 5, subfamily I, member 1	98					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.G98G(1)		endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(34)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	52						GCAGGGCACACCCATAATAGG	0.418000													7	35					5.18039e-06	5.79656e-06	0.278610	1	0
FRMPD2	143162	broad.mit.edu	37	10	49448431	49448431	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr10:49448431C>A	ENST00000374201.3	-	6	974	c.672G>T	c.(670-672)caG>caT	p.Q224H	FRMPD2_ENST00000407470.4_Missense_Mutation_p.Q193H|FRMPD2_ENST00000305531.3_Missense_Mutation_p.Q200H	NM_001018071.3	NP_001018081.3	Q68DX3	FRPD2_HUMAN	FERM and PDZ domain containing 2	224					tight junction assembly	basolateral plasma membrane|cytoplasm|cytoskeleton|tight junction	1-phosphatidylinositol binding|protein binding			NS(2)|autonomic_ganglia(2)|breast(5)|cervix(1)|endometrium(3)|kidney(7)|large_intestine(15)|lung(24)|ovary(2)|prostate(1)|skin(3)|urinary_tract(1)	66				Kidney(211;0.201)		ACTCCGGGGCCTGTGCCGCTG	0.577000													7	49					0.000157383	0.000166564	0.278610	1	0
PYHIN1	149628	broad.mit.edu	37	1	158909030	158909030	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr1:158909030C>T	ENST00000368140.1	+	4	817	c.572C>T	c.(571-573)tCa>tTa	p.S191L	PYHIN1_ENST00000392252.3_Missense_Mutation_p.S182L|PYHIN1_ENST00000368138.3_Missense_Mutation_p.S182L|PYHIN1_ENST00000368135.4_Missense_Mutation_p.S191L|PYHIN1_ENST00000392254.2_Missense_Mutation_p.S191L	NM_152501.4|NM_198928.4|NM_198929.4	NP_689714.2|NP_945146.1|NP_945147.1	Q6K0P9	IFIX_HUMAN	pyrin and HIN domain family, member 1	191					cell cycle	nuclear speck				breast(2)|endometrium(3)|large_intestine(10)|lung(32)|ovary(3)|pancreas(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	60	all_hematologic(112;0.0378)					AACACTTCCTCAACTGAGGTA	0.498000													18	97					0	0	0.608945	0	0
EXOC1	55763	broad.mit.edu	37	4	56770652	56770652	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr4:56770652G>T	ENST00000381295.2	+	19	3024	c.2676G>T	c.(2674-2676)caG>caT	p.Q892H	EXOC1_ENST00000346134.7_Missense_Mutation_p.Q892H|EXOC1_ENST00000349598.6_Missense_Mutation_p.Q877H	NM_001024924.1	NP_001020095.1	Q9NV70	EXOC1_HUMAN	exocyst complex component 1	892					exocytosis|protein transport	exocyst	protein binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(3)|lung(14)|ovary(2)|skin(4)|upper_aerodigestive_tract(1)	35	Glioma(25;0.08)|all_neural(26;0.101)					GCATTGCACAGTCCCACTAAA	0.388000													22	72					1.10513e-12	1.44693e-12	0.624587	1	0
CD200R1	131450	broad.mit.edu	37	3	112643993	112643993	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr3:112643993G>T	ENST00000471858.1	-	5	980	c.748C>A	c.(748-750)Ctt>Att	p.L250I	CD200R1_ENST00000295863.4_Intron|CD200R1_ENST00000308611.3_Missense_Mutation_p.L273I	NM_170780.2	NP_740750.1	Q8TD46	MO2R1_HUMAN	CD200 receptor 1	250					interspecies interaction between organisms|regulation of immune response	extracellular region|integral to membrane|plasma membrane	receptor activity			cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(9)|lung(7)|ovary(2)|pancreas(1)|prostate(1)|skin(1)	26						ATAATAGTAAGGATGATATAT	0.308000													10	38					2.17888e-05	2.35504e-05	0.335167	1	0
GPRIN3	285513	broad.mit.edu	37	4	90170093	90170093	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr4:90170093G>A	ENST00000333209.3	-	2	1687	c.1169C>T	c.(1168-1170)cCa>cTa	p.P390L		NM_198281.2	NP_938022.2	Q6ZVF9	GRIN3_HUMAN	GPRIN family member 3	390			P -> S (in dbSNP:rs11733183).							breast(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(15)|ovary(5)|prostate(2)|skin(1)	36		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;5.67e-05)		GTGCACCTGTGGCATGATGCC	0.567000													38	86					0	0	0.812448	0	0
PPP2R5B	5526	broad.mit.edu	37	11	64694295	64694295	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr11:64694295G>C	ENST00000164133.2	+	3	933	c.311G>C	c.(310-312)cGg>cCg	p.R104P		NM_006244.3	NP_006235.1	Q15173	2A5B_HUMAN	protein phosphatase 2, regulatory subunit B', beta	104					signal transduction	cytoplasm|protein phosphatase type 2A complex	protein binding|protein phosphatase type 2A regulator activity			central_nervous_system(2)|endometrium(4)|kidney(1)|large_intestine(3)|lung(9)|ovary(2)	21						GAGGTGAAGCGGGCAGCCCTC	0.632000													19	74					0	0	0.557998	0	0
RP11-146E13.4	0	broad.mit.edu	37	14	19857007	19857007	+	RNA	SNP	G	G	T			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr14:19857007G>T	ENST00000548109.1	+	0	72																											TCTGTCATGCGTATTATACTC	0.378000													13	39					3.62473e-10	4.53538e-10	0.608945	1	0
FAM86FP	653113	broad.mit.edu	37	12	8386955	8386955	+	RNA	SNP	T	T	C	rs75997195		TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr12:8386955T>C	ENST00000427893.2	-	0	811																											CTTGTGCTCCTGGCAGGCAGC	0.612000													5	59					0	0	0.248553	0	0
TEX26	122046	broad.mit.edu	37	13	31513847	31513847	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr13:31513847G>T	ENST00000380473.3	+	2	91	c.78G>T	c.(76-78)tgG>tgT	p.W26C		NM_152325.1	NP_689538.1	Q8N6G2	CM026_HUMAN	testis expressed 26	26																	ACCCCAACTGGGATTCCTATG	0.358000													12	50					0.000151284	0.000160779	0.435327	1	0
SCO2	9997	broad.mit.edu	37	22	50962824	50962824	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr22:50962824C>G	ENST00000543927.1	-	2	223	c.17G>C	c.(16-18)cGg>cCg	p.R6P	SCO2_ENST00000535425.1_Missense_Mutation_p.R6P|SCO2_ENST00000395693.3_Missense_Mutation_p.R6P|SCO2_ENST00000252785.3_Missense_Mutation_p.R6P	NM_001169109.1	NP_001162580.1	O43819	SCO2_HUMAN	SCO2 cytochrome c oxidase assembly protein	6					cell redox homeostasis|cellular copper ion homeostasis|copper ion transport|oxidation-reduction process|respiratory chain complex IV assembly	mitochondrial inner membrane	copper ion binding			endometrium(1)|lung(1)	2		all_cancers(38;4.58e-14)|all_epithelial(38;1.12e-12)|all_lung(38;3.07e-05)|Breast(42;6.27e-05)|Lung NSC(38;0.000813)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		TGTGGGGCTCCGAGTCAGCAG	0.637000													3	42					0	0	0.115264	0	0
SOX8	30812	broad.mit.edu	37	16	1035178	1035178	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr16:1035178G>A	ENST00000293894.3	+	3	1248	c.1133G>A	c.(1132-1134)gGc>gAc	p.G378D		NM_014587.3	NP_055402.2	P57073	SOX8_HUMAN	SRY (sex determining region Y)-box 8	378					adipose tissue development|enteric nervous system development|fat cell differentiation|in utero embryonic development|metanephric nephron tubule formation|morphogenesis of a branching epithelium|negative regulation of apoptosis|negative regulation of myoblast differentiation|negative regulation of transcription, DNA-dependent|neural crest cell migration|oligodendrocyte differentiation|osteoblast differentiation|peripheral nervous system development|positive regulation of branching involved in ureteric bud morphogenesis|positive regulation of gliogenesis|positive regulation of osteoblast proliferation|positive regulation of transcription from RNA polymerase II promoter|regulation of hormone levels|renal vesicle induction|retinal rod cell differentiation|Sertoli cell development|signal transduction|spermatogenesis|ureter morphogenesis	cytoplasm|nucleus				central_nervous_system(1)|kidney(1)|lung(5)|prostate(2)|skin(1)	10		Hepatocellular(780;0.00308)				cccTTCGCCGGCTCACAGGGC	0.726000													3	28					0	0	0.115264	0	0
KIAA0930	23313	broad.mit.edu	37	22	45599789	45599789	+	Silent	SNP	G	G	A			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr22:45599789G>A	ENST00000336156.4	-	6	659	c.594C>T	c.(592-594)ttC>ttT	p.F198F	KIAA0930_ENST00000251993.7_Silent_p.F203F|KIAA0930_ENST00000391627.2_Silent_p.F164F|KIAA0930_ENST00000443310.3_Silent_p.F180F	NM_001009880.1	NP_001009880.1	Q6ICG6	K0930_HUMAN	KIAA0930	198							protein binding			endometrium(1)|kidney(4)|large_intestine(2)|lung(7)|urinary_tract(1)	15						TGACCCCCTGGAACGTGTTGG	0.587000													16	41					0	0	0.500413	0	0
GLRA1	2741	broad.mit.edu	37	5	151208514	151208514	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr5:151208514G>T	ENST00000274576.4	-	8	1319	c.1027C>A	c.(1027-1029)Ctc>Atc	p.L343I	GLRA1_ENST00000545569.1_Missense_Mutation_p.L260I|GLRA1_ENST00000455880.2_Missense_Mutation_p.L343I	NM_000171.3|NM_001146040.1	NP_000162.2|NP_001139512.1	P23415	GLRA1_HUMAN	glycine receptor, alpha 1	343					muscle contraction|negative regulation of transmission of nerve impulse|neuropeptide signaling pathway|positive regulation of acrosome reaction|regulation of membrane potential|startle response	cell junction|chloride channel complex|integral to plasma membrane|intracellular membrane-bounded organelle|postsynaptic membrane	extracellular-glycine-gated chloride channel activity|glycine binding|protein binding|receptor activity|taurine binding|transmitter-gated ion channel activity			breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(6)|ovary(1)|prostate(1)|skin(3)|urinary_tract(1)	23		all_hematologic(541;0.0341)|Medulloblastoma(196;0.0912)	Kidney(363;0.000171)|KIRC - Kidney renal clear cell carcinoma(527;0.000785)		Desflurane(DB01189)|Enflurane(DB00228)|Ethanol(DB00898)|Glycine(DB00145)|Halothane(DB01159)|Isoflurane(DB00753)|Methoxyflurane(DB01028)|Sevoflurane(DB01236)	CTGAATCGGAGCAGCTCCTTA	0.473000													62	147					8.81991e-31	1.27287e-30	0.870114	1	0
SERPINB11	89778	broad.mit.edu	37	18	61377489	61377489	+	RNA	SNP	G	G	T			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr18:61377489G>T	ENST00000544088.1	+	0	124				SERPINB11_ENST00000382749.5_RNA|SERPINB11_ENST00000489748.1_RNA|SERPINB11_ENST00000538847.1_RNA|SERPINB11_ENST00000536691.1_RNA	NM_080475.2	NP_536723.2	Q96P15	SPB11_HUMAN	serpin peptidase inhibitor, clade B (ovalbumin), member 11 (gene/pseudogene)						regulation of proteolysis	cytoplasm	serine-type endopeptidase inhibitor activity			breast(1)|cervix(1)|kidney(1)|lung(3)	6		Esophageal squamous(42;0.129)				GAGCTGAACAGTAACAACATA	0.438000													15	17					3.27435e-08	3.97936e-08	0.457914	1	0
MTUS2	23281	broad.mit.edu	37	13	29598883	29598883	+	Silent	SNP	G	G	T			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr13:29598883G>T	ENST00000431530.3	+	1	136	c.78G>T	c.(76-78)cgG>cgT	p.R26R		NM_001033602.2	NP_001028774.2	Q5JR59	MTUS2_HUMAN	microtubule associated tumor suppressor candidate 2	16						cytoplasm|microtubule	microtubule binding|protein homodimerization activity			NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(3)|prostate(1)|skin(1)	20						CTCAGTTGCGGGACAACAGAA	0.458000													24	58					9.95505e-16	1.34499e-15	0.624587	1	0
AMZ2P1	201283	broad.mit.edu	37	17	62968690	62968690	+	RNA	SNP	A	A	G	rs138671696	by1000genomes	TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr17:62968690A>G	ENST00000430983.1	-	0	1554					NR_026903.1																						AAAATTCCACAAGTCTCTTGG	0.373000													6	157					0	0	0.217242	0	0
LIMCH1	22998	broad.mit.edu	37	4	41694357	41694357	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr4:41694357G>A	ENST00000313860.7	+	26	3236	c.3182G>A	c.(3181-3183)cGa>cAa	p.R1061Q	LIMCH1_ENST00000508501.1_Missense_Mutation_p.R1034Q|LIMCH1_ENST00000513024.1_Missense_Mutation_p.R888Q|RP11-227F19.5_ENST00000506475.1_RNA|LIMCH1_ENST00000509277.1_Missense_Mutation_p.R894Q|LIMCH1_ENST00000512632.1_Missense_Mutation_p.R958Q|LIMCH1_ENST00000381753.4_Missense_Mutation_p.R868Q|LIMCH1_ENST00000503057.1_Missense_Mutation_p.R1445Q|LIMCH1_ENST00000514096.1_Missense_Mutation_p.R875Q|LIMCH1_ENST00000512946.1_Missense_Mutation_p.R1035Q|LIMCH1_ENST00000396595.3_Missense_Mutation_p.R880Q|LIMCH1_ENST00000511496.1_Missense_Mutation_p.R875Q|LIMCH1_ENST00000512820.1_Missense_Mutation_p.R1047Q	NM_014988.2	NP_055803.2	Q9UPQ0	LIMC1_HUMAN	LIM and calponin homology domains 1	1061	LIM zinc-binding.				actomyosin structure organization		actin binding|zinc ion binding			central_nervous_system(2)|endometrium(1)|large_intestine(9)|lung(17)|ovary(3)|pancreas(1)|prostate(3)|skin(5)	41						GTTAGGATTCGAAATGGTCTC	0.428000													16	64					0	0	0.520397	0	0
FREM1	158326	broad.mit.edu	37	9	14776076	14776076	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr9:14776076C>A	ENST00000380881.4	-	26	5386	c.4571G>T	c.(4570-4572)gGc>gTc	p.G1524V	FREM1_ENST00000380894.1_Missense_Mutation_p.G59V|FREM1_ENST00000422223.2_Missense_Mutation_p.G1523V|FREM1_ENST00000380880.3_Missense_Mutation_p.G1523V			Q5H8C1	FREM1_HUMAN	FRAS1 related extracellular matrix 1	1523					cell communication|multicellular organismal development	basement membrane|integral to membrane	metal ion binding|sugar binding			breast(3)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(40)|ovary(4)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	100				GBM - Glioblastoma multiforme(50;3.53e-06)		GGAAAGCAGGCCCACGGCCCC	0.607000													38	120					8.16277e-20	1.14549e-19	0.827153	1	0
ST6GAL2	84620	broad.mit.edu	37	2	107460224	107460224	+	Silent	SNP	C	C	A			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr2:107460224C>A	ENST00000409382.3	-	2	820	c.210G>T	c.(208-210)ccG>ccT	p.P70P	ST6GAL2_ENST00000409087.3_Silent_p.P70P|ST6GAL2_ENST00000361686.4_Silent_p.P70P	NM_001142351.1	NP_001135823.1	Q96JF0	SIAT2_HUMAN	ST6 beta-galactosamide alpha-2,6-sialyltranferase 2	70					growth|multicellular organismal development|oligosaccharide metabolic process|protein glycosylation	Golgi cisterna membrane|integral to Golgi membrane	beta-galactoside alpha-2,6-sialyltransferase activity			autonomic_ganglia(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(8)|liver(1)|lung(30)|ovary(5)|pancreas(6)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	65						GGCCCCCAGGCGGGGAGGGCT	0.706000													16	34					1.52009e-12	1.98002e-12	0.479597	1	0
PLEKHF1	79156	broad.mit.edu	37	19	30165102	30165102	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr19:30165102G>A	ENST00000436066.3	+	2	822	c.356G>A	c.(355-357)cGc>cAc	p.R119H	PLEKHF1_ENST00000592810.1_Missense_Mutation_p.R119H	NM_024310.4	NP_077286.3	Q96S99	PKHF1_HUMAN	pleckstrin homology domain containing, family F (with FYVE domain) member 1	119	PH.				apoptosis	lysosome|nucleus|perinuclear region of cytoplasm	metal ion binding			breast(1)|lung(3)|ovary(1)|prostate(1)	6	Ovarian(5;0.000567)|Breast(6;0.0602)|Esophageal squamous(110;0.239)		UCEC - Uterine corpus endometrioid carcinoma (4;2.65e-06)|STAD - Stomach adenocarcinoma(5;1.7e-06)|Lung(7;0.0623)|LUAD - Lung adenocarcinoma(5;0.0989)|BRCA - Breast invasive adenocarcinoma(6;0.225)			GCTACGGAGCGCCAGGAATGG	0.667000													4	41					0	0	0.150653	0	0
PEPD	5184	broad.mit.edu	37	19	33980911	33980911	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr19:33980911C>A	ENST00000244137.6	-	6	527	c.494G>T	c.(493-495)gGc>gTc	p.G165V	PEPD_ENST00000397032.4_Missense_Mutation_p.G165V|PEPD_ENST00000436370.3_Missense_Mutation_p.G101V	NM_000285.3	NP_000276.2	P12955	PEPD_HUMAN	peptidase D	165					cellular amino acid metabolic process|collagen catabolic process|proteolysis		aminopeptidase activity|dipeptidase activity|manganese ion binding|metallocarboxypeptidase activity			endometrium(3)|kidney(3)|large_intestine(2)|lung(7)|ovary(2)	17	Esophageal squamous(110;0.137)					CTTGCTGATGCCGTCAAAGGA	0.612000													5	18					5.9392e-07	6.85708e-07	0.217242	1	0
TRAV26-2	28656	broad.mit.edu	37	14	22671163	22671163	+	RNA	SNP	G	G	T			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr14:22671163G>T	ENST00000390460.1	+	0	228																											ACAACAGAATGGCCTCTCTGG	0.488000													12	41					3.07112e-06	3.48243e-06	0.387290	1	0
POLR3G	10622	broad.mit.edu	37	5	89783891	89783891	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr5:89783891G>C	ENST00000399107.1	+	3	392	c.192G>C	c.(190-192)ttG>ttC	p.L64F	POLR3G_ENST00000504930.1_Missense_Mutation_p.L64F|POLR3G_ENST00000514483.1_Missense_Mutation_p.L64F	NM_006467.2	NP_006458.2	O15318	RPC7_HUMAN	polymerase (RNA) III (DNA directed) polypeptide G (32kD)	64					innate immune response|positive regulation of innate immune response|positive regulation of interferon-beta production|regulation of transcription from RNA polymerase III promoter|response to virus	DNA-directed RNA polymerase III complex	DNA-directed RNA polymerase activity			cervix(1)|endometrium(1)|kidney(2)|lung(4)|prostate(1)	9		all_cancers(142;5.03e-09)|all_epithelial(76;1.23e-11)|Lung NSC(167;2.46e-05)|all_lung(232;3.25e-05)|Ovarian(174;0.00832)|Colorectal(57;0.122)|Breast(839;0.198)		OV - Ovarian serous cystadenocarcinoma(54;2.74e-31)|Epithelial(54;8.2e-26)|all cancers(79;3.86e-22)		AACAGGAGTTGAGAGAAACAA	0.338000													15	72					0	0	0.500413	0	0
CPQ	10404	broad.mit.edu	37	8	97847327	97847327	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr8:97847327G>A	ENST00000220763.5	+	3	770	c.560G>A	c.(559-561)cGa>cAa	p.R187Q		NM_016134.2	NP_057218.1	Q9Y646	PGCP_HUMAN	carboxypeptidase Q	187					peptide metabolic process|proteolysis	cytoplasm|extracellular space	metal ion binding|metallocarboxypeptidase activity										GTGCAATACCGAACGCAGGGG	0.502000													15	74					0	0	0.500413	0	0
OR8J3	81168	broad.mit.edu	37	11	55905192	55905192	+	Translation_Start_Site	SNP	C	C	T			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr11:55905192C>T	ENST00000301529.1	-	1	2	c.3G>A	c.(1-3)atG>atA	p.M1I		NM_001004064.1	NP_001004064.1	Q8NGG0	OR8J3_HUMAN	olfactory receptor, family 8, subfamily J, member 3	1					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(1)|lung(38)|pancreas(1)|prostate(1)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)	59	Esophageal squamous(21;0.00693)					TTTCAGGAGCCATGTCAGAGT	0.428000													27	53					0	0	0.681144	0	0
CNTN4	152330	broad.mit.edu	37	3	2944582	2944582	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr3:2944582G>T	ENST00000397461.1	+	11	1484	c.1100G>T	c.(1099-1101)gGa>gTa	p.G367V	CNTN4_ENST00000418658.1_Missense_Mutation_p.G367V|CNTN4_ENST00000358480.3_Missense_Mutation_p.G148V|CNTN4_ENST00000475817.1_3'UTR|CNTN4_ENST00000427331.1_Missense_Mutation_p.G367V|CNTN4_ENST00000397459.2_Missense_Mutation_p.G39V|CNTN4_ENST00000448906.2_Missense_Mutation_p.G39V	NM_001206955.1	NP_001193884.1	Q8IWV2	CNTN4_HUMAN	contactin 4	367	Ig-like C2-type 4.				axon guidance|axonal fasciculation|brain development|negative regulation of neuron differentiation|neuron cell-cell adhesion|regulation of synaptic plasticity	anchored to membrane|axon|extracellular region|plasma membrane	protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(14)|lung(19)|ovary(2)|pancreas(4)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	61		Ovarian(110;0.156)		Epithelial(13;0.000695)|all cancers(10;0.0047)|OV - Ovarian serous cystadenocarcinoma(96;0.01)		ATTGAGCAAGGAACACTCAAC	0.363000													6	15					0.00116845	0.00122638	0.217242	1	0
NLRP11	204801	broad.mit.edu	37	19	56307481	56307481	+	Silent	SNP	G	G	T			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr19:56307481G>T	ENST00000443188.1	-	8	3017	c.2307C>A	c.(2305-2307)gcC>gcA	p.A769A	NLRP11_ENST00000589824.2_Silent_p.A715A|NLRP11_ENST00000360133.3_Silent_p.A715A|NLRP11_ENST00000589093.1_Silent_p.A769A|NLRP11_ENST00000592953.1_Silent_p.A670A	NM_145007.3	NP_659444.2	P59045	NAL11_HUMAN	NLR family, pyrin domain containing 11	769							ATP binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(4)|kidney(1)|large_intestine(14)|lung(22)|ovary(3)|pancreas(1)|prostate(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)	66		Colorectal(82;0.0002)		GBM - Glioblastoma multiforme(193;0.0325)		GATGAAGCAAGGCATCACACA	0.483000													72	257					1.37693e-34	2.01001e-34	0.870114	1	0
PCDHA4	56144	broad.mit.edu	37	5	140188457	140188457	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr5:140188457C>T	ENST00000530339.1	+	1	1685	c.1685C>T	c.(1684-1686)gCg>gTg	p.A562V	PCDHA2_ENST00000526136.1_Intron|PCDHA4_ENST00000512229.2_Missense_Mutation_p.A562V|PCDHA1_ENST00000504120.2_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA4_ENST00000356878.4_Missense_Mutation_p.A562V	NM_018907.2	NP_061730.1														breast(6)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(12)|lung(33)|ovary(6)|pancreas(1)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	78			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AACGACAACGCGCCAGCACTG	0.672000													27	62					0	0	0.681144	0	0
OR8K5	219453	broad.mit.edu	37	11	55927495	55927495	+	Missense_Mutation	SNP	T	T	A			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr11:55927495T>A	ENST00000313447.1	-	1	298	c.299A>T	c.(298-300)cAg>cTg	p.Q100L		NM_001004058.2	NP_001004058.2	Q8NH50	OR8K5_HUMAN	olfactory receptor, family 8, subfamily K, member 5	100					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(3)|lung(24)|ovary(2)|pancreas(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	34	Esophageal squamous(21;0.00693)	Lung NSC(402;0.197)|all_epithelial(135;0.236)				GAATGCCAGCTGTGCAGCACA	0.408000													24	104					0	0	0.654019	0	0
FRMPD2	143162	broad.mit.edu	37	10	49448430	49448430	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr10:49448430C>T	ENST00000374201.3	-	6	975	c.673G>A	c.(673-675)Gcc>Acc	p.A225T	FRMPD2_ENST00000407470.4_Missense_Mutation_p.A194T|FRMPD2_ENST00000305531.3_Missense_Mutation_p.A201T	NM_001018071.3	NP_001018081.3	Q68DX3	FRPD2_HUMAN	FERM and PDZ domain containing 2	225					tight junction assembly	basolateral plasma membrane|cytoplasm|cytoskeleton|tight junction	1-phosphatidylinositol binding|protein binding			NS(2)|autonomic_ganglia(2)|breast(5)|cervix(1)|endometrium(3)|kidney(7)|large_intestine(15)|lung(24)|ovary(2)|prostate(1)|skin(3)|urinary_tract(1)	66				Kidney(211;0.201)		CACTCCGGGGCCTGTGCCGCT	0.582000													7	49					0	0	0.278610	0	0
TEX26	122046	broad.mit.edu	37	13	31513846	31513846	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr13:31513846G>T	ENST00000380473.3	+	2	90	c.77G>T	c.(76-78)tGg>tTg	p.W26L		NM_152325.1	NP_689538.1	Q8N6G2	CM026_HUMAN	testis expressed 26	26																	GACCCCAACTGGGATTCCTAT	0.358000													11	49					0.00136819	0.00143013	0.411799	1	0
ZFHX4	79776	broad.mit.edu	37	8	77768313	77768313	+	Silent	SNP	G	G	C			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr8:77768313G>C	ENST00000521891.2	+	10	9604	c.9156G>C	c.(9154-9156)ccG>ccC	p.P3052P	ZFHX4_ENST00000050961.6_Silent_p.P3007P|ZFHX4_ENST00000455469.2_Silent_p.P3007P|ZFHX4_ENST00000518282.1_Silent_p.P3026P	NM_024721.4	NP_078997.4	Q86UP3	ZFHX4_HUMAN	zinc finger homeobox 4	3007	Pro-rich.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding	p.P3036P(2)		NS(3)|breast(11)|central_nervous_system(1)|endometrium(36)|haematopoietic_and_lymphoid_tissue(2)|kidney(15)|large_intestine(66)|liver(2)|lung(245)|ovary(11)|pancreas(3)|prostate(11)|skin(7)|upper_aerodigestive_tract(13)|urinary_tract(6)	432			BRCA - Breast invasive adenocarcinoma(89;0.0895)			ACTTGGCTCCGACCACGGTTC	0.507000										HNSCC(33;0.089)			12	149					0	0	0.457914	0	0
RPS6KB1	6198	broad.mit.edu	37	17	58018242	58018242	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr17:58018242C>G	ENST00000225577.4	+	13	1186	c.1165C>G	c.(1165-1167)Cag>Gag	p.Q389E	RPS6KB1_ENST00000393021.3_Missense_Mutation_p.Q336E|RPS6KB1_ENST00000406116.3_Missense_Mutation_p.Q389E|RPS6KB1_ENST00000443572.2_Missense_Mutation_p.Q366E	NM_001272042.1|NM_001272044.1|NM_001272060.1|NM_003161.2	NP_001258971.1|NP_001258973.1|NP_001258989.1|NP_003152.1	P23443	KS6B1_HUMAN	ribosomal protein S6 kinase, 70kDa, polypeptide 1	389	AGC-kinase C-terminal.				apoptosis|G1/S transition of mitotic cell cycle|insulin receptor signaling pathway|negative regulation of apoptosis|phosphatidylinositol-mediated signaling|positive regulation of mitotic cell cycle|positive regulation of translational initiation|TOR signaling cascade	cell junction|cytoplasm|cytosol|mitochondrial outer membrane|nucleus|synapse|synaptosome	ATP binding|protein binding|protein kinase activity			endometrium(1)|kidney(2)|large_intestine(5)|lung(4)|ovary(1)|upper_aerodigestive_tract(1)	14	all_cancers(5;1.63e-13)|Breast(5;2.91e-25)|all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		Epithelial(12;3.57e-12)|all cancers(12;6.41e-11)			GTTTACACGTCAGACACCTGT	0.358000													20	85					0	0	0.654019	0	0
CD200R1	131450	broad.mit.edu	37	3	112643994	112643994	+	Silent	SNP	G	G	T			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr3:112643994G>T	ENST00000471858.1	-	5	979	c.747C>A	c.(745-747)atC>atA	p.I249I	CD200R1_ENST00000295863.4_Intron|CD200R1_ENST00000308611.3_Silent_p.I272I	NM_170780.2	NP_740750.1	Q8TD46	MO2R1_HUMAN	CD200 receptor 1	249					interspecies interaction between organisms|regulation of immune response	extracellular region|integral to membrane|plasma membrane	receptor activity			cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(9)|lung(7)|ovary(2)|pancreas(1)|prostate(1)|skin(1)	26						TAATAGTAAGGATGATATATG	0.308000													10	34					2.17888e-05	2.35504e-05	0.335167	1	0
ZNF536	9745	broad.mit.edu	37	19	30935517	30935517	+	Missense_Mutation	SNP	T	T	G			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr19:30935517T>G	ENST00000355537.3	+	2	1195	c.1048T>G	c.(1048-1050)Tgc>Ggc	p.C350G		NM_014717.1	NP_055532.1	O15090	ZN536_HUMAN	zinc finger protein 536	350					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			NS(3)|breast(6)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|lung(119)|ovary(7)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(3)	182	Esophageal squamous(110;0.0834)					CTGCGAGGTGTGCGGTCAGGT	0.652000													56	150					0	0	0.870114	0	0
SAG	6295	broad.mit.edu	37	2	234238223	234238223	+	Splice_Site	SNP	G	G	T			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr2:234238223G>T	ENST00000409110.1	+	9	963	c.733_splice	c.e9+1	p.V245_splice	SAG_ENST00000449594.2_Splice_Site_p.V111_splice	NM_000541.4	NP_000532.2	P10523	ARRS_HUMAN	S-antigen; retina and pineal gland (arrestin)	245					rhodopsin mediated phototransduction|rhodopsin mediated signaling pathway		protein phosphatase inhibitor activity			cervix(1)|kidney(2)|lung(4)|ovary(1)|upper_aerodigestive_tract(1)	9		Breast(86;0.0013)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.018)|Acute lymphoblastic leukemia(138;0.0327)|Lung NSC(271;0.054)		Epithelial(121;2.86e-17)|BRCA - Breast invasive adenocarcinoma(100;0.00037)|LUSC - Lung squamous cell carcinoma(224;0.00608)|Lung(119;0.00714)|GBM - Glioblastoma multiforme(43;0.207)		TAAAGCATTCGGTAGGACCTT	0.468000													16	19					6.31663e-08	7.6039e-08	0.479597	1	0
VPS13B	157680	broad.mit.edu	37	8	100866425	100866425	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr8:100866425C>T	ENST00000358544.2	+	56	10994	c.10883C>T	c.(10882-10884)gCg>gTg	p.A3628V	VPS13B_ENST00000395996.1_3'UTR|VPS13B_ENST00000357162.2_Missense_Mutation_p.A3603V	NM_017890.4	NP_060360.3	Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13 homolog B (yeast)	3628					protein transport			p.A3628V(1)|p.A3603V(1)		NS(1)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(37)|lung(78)|ovary(8)|pancreas(3)|prostate(5)|skin(9)|upper_aerodigestive_tract(4)|urinary_tract(9)	193	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			TTCACCACTGCGAGGCAGCTT	0.557000													14	59					0	0	0.435327	0	0
ZDHHC1	29800	broad.mit.edu	37	16	67428917	67428917	+	Silent	SNP	C	C	A			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr16:67428917C>A	ENST00000348579.2	-	10	1559	c.1218G>T	c.(1216-1218)cgG>cgT	p.R406R	ZDHHC1_ENST00000566075.1_5'UTR	NM_013304.2	NP_037436.1	Q8WTX9	ZDHC1_HUMAN	zinc finger, DHHC-type containing 1	406						integral to membrane	DNA binding|zinc ion binding			breast(2)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(1)|urinary_tract(1)	10		Ovarian(137;0.223)		UCEC - Uterine corpus endometrioid carcinoma (183;0.0178)|all cancers(182;5.71e-53)|Epithelial(162;4.73e-52)|OV - Ovarian serous cystadenocarcinoma(108;1.53e-29)|Kidney(780;4.37e-05)|BRCA - Breast invasive adenocarcinoma(181;5.8e-05)|GBM - Glioblastoma multiforme(240;0.0022)		GACGCCGGATCCGAGGTCTCA	0.632000													4	20					0.00909568	0.00924121	0.150653	1	0
TRBV6-6	28601	broad.mit.edu	37	7	142162211	142162211	+	RNA	SNP	C	C	T			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr7:142162211C>T	ENST00000390371.3	-	0	107																											TGAGTGACACCAGCATTCACT	0.527000													21	62					0	0	0.575678	0	0
MUC16	94025	broad.mit.edu	37	19	9011464	9011464	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr19:9011464C>T	ENST00000397910.4	-	36	38972	c.38769G>A	c.(38767-38769)atG>atA	p.M12923I		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	12925	SEA 6.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						AGATGGCATCCATTCCAGTGG	0.537000													15	130					0	0	0.539581	0	0
CA5B	11238	broad.mit.edu	37	X	15800702	15800702	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chrX:15800702G>T	ENST00000318636.3	+	8	1005	c.869G>T	c.(868-870)cGc>cTc	p.R290L	CA5B_ENST00000454127.2_Missense_Mutation_p.R290L	NM_007220.3	NP_009151.1	Q9Y2D0	CAH5B_HUMAN	carbonic anhydrase VB, mitochondrial	290					one-carbon metabolic process	mitochondrion	carbonate dehydratase activity|zinc ion binding			endometrium(1)|kidney(2)|lung(3)|prostate(1)|stomach(2)	9	Hepatocellular(33;0.183)					CTGATGAATCGCACTGTTCGT	0.493000													8	26					1.06961e-07	1.28152e-07	0.278610	1	0
NSUN5	55695	broad.mit.edu	37	7	72718748	72718748	+	Nonsense_Mutation	SNP	G	G	A			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr7:72718748G>A	ENST00000428206.1	-	6	650	c.637C>T	c.(637-639)Caa>Taa	p.Q213*	NSUN5_ENST00000310326.8_Nonsense_Mutation_p.Q251*|NSUN5_ENST00000438747.2_Nonsense_Mutation_p.Q251*|NSUN5_ENST00000252594.6_Nonsense_Mutation_p.Q251*	NM_001168348.1	NP_001161820.1	Q96P11	NSUN5_HUMAN	NOP2/Sun domain family, member 5	251							methyltransferase activity			breast(1)|endometrium(3)|large_intestine(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	8		Lung NSC(55;0.163)				ACTCACCCTTGGTTCTTCAGA	0.557000													10	33					0	0	0.457914	0	0
OR1C1	26188	broad.mit.edu	37	1	247921189	247921189	+	Missense_Mutation	SNP	T	T	C			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr1:247921189T>C	ENST00000408896.2	-	1	793	c.520A>G	c.(520-522)Atc>Gtc	p.I174V		NM_012353.2	NP_036485.2	Q15619	OR1C1_HUMAN	olfactory receptor, family 1, subfamily C, member 1	174					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(32)|skin(2)|upper_aerodigestive_tract(1)	46	all_cancers(71;4.34e-05)|all_epithelial(71;1.13e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0786)|Lung NSC(105;0.0858)	all_cancers(173;0.0247)	OV - Ovarian serous cystadenocarcinoma(106;0.0168)			AAATGATGGATGATATTGGAG	0.478000													15	18					0	0	0.500413	0	0
MTRF1	9617	broad.mit.edu	37	13	41827091	41827091	+	Missense_Mutation	SNP	T	T	C			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr13:41827091T>C	ENST00000379480.4	-	4	683	c.583A>G	c.(583-585)Act>Gct	p.T195A	MTRF1_ENST00000239852.6_5'UTR|MTRF1_ENST00000430347.2_Missense_Mutation_p.T208A|MTRF1_ENST00000379477.1_Missense_Mutation_p.T195A	NM_004294.2	NP_004285.2	O75570	RF1M_HUMAN	mitochondrial translational release factor 1	195					regulation of translational termination	mitochondrion	translation release factor activity, codon specific			breast(1)|endometrium(4)|large_intestine(3)|lung(6)	14		Lung NSC(96;4.52e-06)|Breast(139;0.00123)|Prostate(109;0.0181)|Lung SC(185;0.0262)|Hepatocellular(98;0.114)|Ovarian(182;0.125)		OV - Ovarian serous cystadenocarcinoma(117;4.24e-10)|all cancers(112;2.05e-09)|Epithelial(112;2.48e-09)|GBM - Glioblastoma multiforme(144;0.00115)|BRCA - Breast invasive adenocarcinoma(63;0.0721)|KIRC - Kidney renal clear cell carcinoma(186;0.248)		TGACCTCCAGTAGTCCTTCCA	0.313000													18	36					0	0	0.539581	0	0
EXOC6B	23233	broad.mit.edu	37	2	72562091	72562091	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr2:72562091G>T	ENST00000272427.6	-	20	2311	c.2181C>A	c.(2179-2181)ttC>ttA	p.F727L	EXOC6B_ENST00000490919.1_5'UTR	NM_015189.1	NP_056004.1	Q9Y2D4	EXC6B_HUMAN	exocyst complex component 6B	727					protein transport|vesicle docking involved in exocytosis	exocyst				breast(1)|central_nervous_system(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(3)	10						TCAAGTCGATGAAGGCCAACT	0.458000													27	78					2.14196e-07	2.5305e-07	0.717897	1	0
PRDM10	56980	broad.mit.edu	37	11	129814722	129814722	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr11:129814722C>T	ENST00000358825.5	-	6	937	c.706G>A	c.(706-708)Gtg>Atg	p.V236M	PRDM10_ENST00000423662.2_Missense_Mutation_p.V150M|PRDM10_ENST00000304538.6_Missense_Mutation_p.V150M|PRDM10_ENST00000360871.3_Missense_Mutation_p.V236M|PRDM10_ENST00000526082.1_Missense_Mutation_p.V150M|PRDM10_ENST00000528746.1_Missense_Mutation_p.V210M	NM_020228.2	NP_064613.2	Q9NQV6	PRD10_HUMAN	PR domain containing 10	236	SET.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(6)|kidney(3)|large_intestine(14)|lung(15)|pancreas(2)|skin(1)|stomach(3)|urinary_tract(2)	48	all_hematologic(175;0.0537)	Breast(109;0.000496)|Lung NSC(97;0.000693)|all_lung(97;0.00151)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.0174)|Lung(977;0.176)|LUSC - Lung squamous cell carcinoma(976;0.185)		GGCCCCTCCACGGGGCCAAAC	0.592000													16	117					0	0	0.479597	0	0
KRT32	3882	broad.mit.edu	37	17	39619225	39619225	+	Silent	SNP	G	G	T			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr17:39619225G>T	ENST00000225899.3	-	6	1177	c.1074C>A	c.(1072-1074)atC>atA	p.I358I		NM_002278.3	NP_002269.3	Q14532	K1H2_HUMAN	keratin 32	358	Coil 2.|Rod.				epidermis development	intermediate filament	protein binding|structural molecule activity			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(6)|ovary(1)|prostate(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	21		Breast(137;0.000812)				CAACGTTGGTGATCATGCACT	0.632000													31	80					1.55811e-20	2.19867e-20	0.729181	1	0
YEATS2	55689	broad.mit.edu	37	3	183521783	183521783	+	Missense_Mutation	SNP	A	A	T			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr3:183521783A>T	ENST00000305135.5	+	27	3786	c.3591A>T	c.(3589-3591)agA>agT	p.R1197S		NM_018023.4	NP_060493.3	Q9ULM3	YETS2_HUMAN	YEATS domain containing 2	1197					histone H3 acetylation|negative regulation of transcription from RNA polymerase II promoter	Ada2/Gcn5/Ada3 transcription activator complex	TBP-class protein binding			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(24)|ovary(3)|prostate(2)|skin(3)	49	all_cancers(143;6.55e-10)|Ovarian(172;0.0303)		all cancers(12;2.38e-42)|Epithelial(37;1.9e-36)|OV - Ovarian serous cystadenocarcinoma(80;6.48e-22)			AGTGGCAAAGAGCAATGACAA	0.403000													29	63					0	0	0.729181	0	0
CLDND1	56650	broad.mit.edu	37	3	98235667	98235667	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr3:98235667G>C	ENST00000503004.1	-	5	1477	c.598C>G	c.(598-600)Cag>Gag	p.Q200E	CLDND1_ENST00000437922.1_Missense_Mutation_p.Q223E|CLDND1_ENST00000394185.2_Missense_Mutation_p.Q200E|CLDND1_ENST00000341181.6_Missense_Mutation_p.Q200E|CLDND1_ENST00000394181.2_Missense_Mutation_p.Q200E|CLDND1_ENST00000513287.1_Missense_Mutation_p.Q200E|CLDND1_ENST00000502288.1_Intron|CLDND1_ENST00000511081.1_Missense_Mutation_p.Q105E|CLDND1_ENST00000510545.1_Missense_Mutation_p.Q200E|CLDND1_ENST00000508503.1_5'UTR|CLDND1_ENST00000394180.2_Missense_Mutation_p.Q200E|CLDND1_ENST00000507874.1_Intron			Q9NY35	CLDN1_HUMAN	claudin domain containing 1	200						integral to membrane				central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(4)|ovary(1)	9						TCTAGTTTCTGGTGGAGTAGT	0.448000													17	35					0	0	0.539581	0	0
TRBV6-5	28602	broad.mit.edu	37	7	142180910	142180910	+	RNA	SNP	A	A	T			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr7:142180910A>T	ENST00000390368.2	-	0	106																											ACCTGCCCACAGGAGAGACAA	0.582000													14	51					0	0	0.479597	0	0
ZBTB26	57684	broad.mit.edu	37	9	125681304	125681304	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr9:125681304C>A	ENST00000373656.3	-	2	983	c.910G>T	c.(910-912)Ggc>Tgc	p.G304C	ZBTB26_ENST00000373654.1_Missense_Mutation_p.G304C	NM_020924.2	NP_065975.1	Q9HCK0	ZBT26_HUMAN	zinc finger and BTB domain containing 26	304					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(4)|prostate(1)	11						AAAGTCTTGCCGCAGAGTAGA	0.458000													36	50					1.06647e-15	1.43325e-15	0.788014	1	0
OCA2	4948	broad.mit.edu	37	15	28263576	28263576	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr15:28263576G>T	ENST00000354638.3	-	7	929	c.774C>A	c.(772-774)gaC>gaA	p.D258E	OCA2_ENST00000382996.2_Missense_Mutation_p.D258E|OCA2_ENST00000353809.5_Missense_Mutation_p.D258E	NM_000275.2	NP_000266.2	Q04671	P_HUMAN	oculocutaneous albinism II	258					eye pigment biosynthetic process	endoplasmic reticulum membrane|endosome membrane|integral to membrane|lysosomal membrane|melanosome membrane	arsenite transmembrane transporter activity|citrate transmembrane transporter activity|L-tyrosine transmembrane transporter activity|protein binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(7)|kidney(3)|large_intestine(11)|lung(48)|ovary(4)|pancreas(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	85		all_lung(180;2.93e-12)|Breast(32;0.000315)|Colorectal(260;0.234)		all cancers(64;5.03e-07)|Epithelial(43;2.13e-06)|BRCA - Breast invasive adenocarcinoma(123;0.045)		AGCCCAAAGCGTCAGCCTGGG	0.547000									Oculocutaneous Albinism				7	39					0.0581538	0.0586153	0.335167	1	0
RP11-146E13.4	0	broad.mit.edu	37	14	19857036	19857036	+	RNA	SNP	A	A	G			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr14:19857036A>G	ENST00000548109.1	+	0	72																											CTGGATAATAAAGTTCATCTC	0.373000													4	60					0	0	0.184627	0	0
GPR133	283383	broad.mit.edu	37	12	131498749	131498749	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr12:131498749C>T	ENST00000261654.5	+	13	1896	c.1337C>T	c.(1336-1338)gCg>gTg	p.A446V	GPR133_ENST00000376682.4_Missense_Mutation_p.A132V|GPR133_ENST00000535015.1_Missense_Mutation_p.A478V	NM_198827.3	NP_942122.2	Q6QNK2	GP133_HUMAN	G protein-coupled receptor 133	446					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(2)|breast(2)|endometrium(6)|kidney(1)|large_intestine(12)|lung(20)|ovary(3)|pancreas(6)|prostate(6)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(4)	67	all_neural(191;0.0982)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.68e-06)|all cancers(50;2.71e-06)|Epithelial(86;6.75e-06)		CCAAGGATCGCGGAGGCCATG	0.587000													9	51					0	0	0.361761	0	0
RAD51AP2	729475	broad.mit.edu	37	2	17696895	17696895	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr2:17696895G>C	ENST00000399080.2	-	1	2811	c.2788C>G	c.(2788-2790)Caa>Gaa	p.Q930E		NM_001099218.2	NP_001092688.1	Q09MP3	R51A2_HUMAN	RAD51 associated protein 2	930										endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(10)|liver(1)|lung(17)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	49	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.158)					GTTTCAAATTGATGATTAATA	0.313000													20	45					0	0	0.557998	0	0
TNFSF11	8600	broad.mit.edu	37	13	43155388	43155388	+	Missense_Mutation	SNP	T	T	A			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr13:43155388T>A	ENST00000398795.2	+	2	495	c.127T>A	c.(127-129)Tgt>Agt	p.C43S	TNFSF11_ENST00000239849.6_Missense_Mutation_p.C116S|TNFSF11_ENST00000544862.1_Missense_Mutation_p.C43S|TNFSF11_ENST00000405262.2_Missense_Mutation_p.C43S|TNFSF11_ENST00000358545.2_Missense_Mutation_p.C43S	NM_003701.3	NP_003692.1	O14788	TNF11_HUMAN	tumor necrosis factor (ligand) superfamily, member 11	116					immune response|monocyte chemotaxis|osteoclast differentiation|positive regulation of bone resorption|positive regulation of corticotropin-releasing hormone secretion|positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling|positive regulation of fever generation by positive regulation of prostaglandin secretion|positive regulation of homotypic cell-cell adhesion|positive regulation of NF-kappaB transcription factor activity|positive regulation of osteoclast differentiation|positive regulation of T cell activation	cytoplasm|extracellular space|integral to plasma membrane	cytokine activity|receptor activity|tumor necrosis factor receptor binding			kidney(1)|large_intestine(4)|lung(3)|prostate(1)|urinary_tract(1)	10		Lung NSC(96;1.11e-05)|Breast(139;0.00868)|Prostate(109;0.0181)|Lung SC(185;0.0262)|Hepatocellular(98;0.114)		OV - Ovarian serous cystadenocarcinoma(117;0.000249)|GBM - Glioblastoma multiforme(144;0.00119)|BRCA - Breast invasive adenocarcinoma(63;0.073)		ACCTGATTCATGTAGGAGAAT	0.403000													18	64					0	0	0.557998	0	0
FMO1	2326	broad.mit.edu	37	1	171251200	171251200	+	Missense_Mutation	SNP	A	A	G			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr1:171251200A>G	ENST00000354841.4	+	6	1042	c.911A>G	c.(910-912)aAa>aGa	p.K304R	FMO1_ENST00000469112.1_3'UTR|FMO1_ENST00000367750.3_Missense_Mutation_p.K304R|FMO1_ENST00000402921.2_Missense_Mutation_p.K241R			Q01740	FMO1_HUMAN	flavin containing monooxygenase 1	304					NADPH oxidation|organic acid metabolic process|toxin metabolic process|xenobiotic metabolic process	endoplasmic reticulum lumen|integral to membrane|intrinsic to endoplasmic reticulum membrane|microsome	flavin adenine dinucleotide binding|flavin-containing monooxygenase activity|NADP binding			NS(1)|breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(13)|prostate(2)|skin(2)	27	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					CCAAGCATAAAAGAGGTAAAG	0.403000													20	77					0	0	0.557998	0	0
SLC41A2	84102	broad.mit.edu	37	12	105198953	105198953	+	Nonsense_Mutation	SNP	G	G	A			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr12:105198953G>A	ENST00000258538.3	-	10	1826	c.1699C>T	c.(1699-1701)Cga>Tga	p.R567*	SLC41A2_ENST00000549713.1_5'UTR	NM_032148.3	NP_115524.3	Q96JW4	S41A2_HUMAN	solute carrier family 41 (magnesium transporter), member 2	567						integral to membrane|plasma membrane	magnesium ion transmembrane transporter activity			breast(1)|endometrium(2)|kidney(3)|large_intestine(2)|lung(6)|ovary(2)|skin(4)|stomach(1)|urinary_tract(1)	22						TCTCCATCTCGATCTCCAATA	0.418000													24	294					0	0	0.667858	0	0
OR1D2	4991	broad.mit.edu	37	17	2995442	2995442	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr17:2995442C>T	ENST00000331459.1	-	1	848	c.849G>A	c.(847-849)atG>atA	p.M283I		NM_002548.2	NP_002539.2	P34982	OR1D2_HUMAN	olfactory receptor, family 1, subfamily D, member 2	283					cellular component movement|chemotaxis|protein import into nucleus, translocation|sensory perception of smell|single fertilization	integral to plasma membrane	olfactory receptor activity			kidney(2)|large_intestine(2)|lung(10)|ovary(1)	15						AGGGATTCATCATGGGTGTCA	0.473000													23	69					0	0	0.608945	0	0
TSSC2	650368	broad.mit.edu	37	11	3427845	3427845	+	RNA	SNP	C	C	T			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr11:3427845C>T	ENST00000529482.1	+	0	962																											CTTCAAGTGGCAGGAGCAGAA	0.587000													4	45					0	0	0.150653	0	0
PLXNB2	23654	broad.mit.edu	37	22	50721182	50721182	+	Missense_Mutation	SNP	T	T	G			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr22:50721182T>G	ENST00000449103.1	-	18	3085	c.2945A>C	c.(2944-2946)aAc>aCc	p.N982T	PLXNB2_ENST00000359337.4_Missense_Mutation_p.N982T			O15031	PLXB2_HUMAN	plexin B2	982					regulation of small GTPase mediated signal transduction	integral to membrane|intracellular	GTPase activator activity|protein binding|receptor activity			breast(2)|central_nervous_system(4)|cervix(2)|endometrium(11)|kidney(4)|large_intestine(3)|liver(1)|lung(20)|ovary(5)|prostate(6)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	66		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		CAGTACGGGGTTTTCGCGGTA	0.677000													5	14					0	0	0.278610	0	0
ADD3	120	broad.mit.edu	37	10	111878980	111878980	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr10:111878980G>T	ENST00000277900.8	+	7	1094	c.729G>T	c.(727-729)atG>atT	p.M243I	ADD3_ENST00000356080.4_Missense_Mutation_p.M243I|ADD3_ENST00000360162.3_Missense_Mutation_p.M243I	NM_001121.2	NP_001112.2	Q9UEY8	ADDG_HUMAN	adducin 3 (gamma)	243						cytoskeleton	actin binding|calmodulin binding|metal ion binding|structural constituent of cytoskeleton			central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(4)|lung(9)|ovary(2)|pancreas(1)|prostate(1)|skin(3)	29		Breast(234;0.052)|Lung NSC(174;0.223)		Epithelial(162;4.15e-05)|all cancers(201;0.000587)|BRCA - Breast invasive adenocarcinoma(275;0.0742)		TATCCTCCATGAAATGTGGGA	0.408000													18	53					1.45105e-14	1.93983e-14	0.539581	1	0
PPP1R12A	4659	broad.mit.edu	37	12	80266692	80266692	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr12:80266692C>A	ENST00000450142.2	-	2	530	c.264G>T	c.(262-264)atG>atT	p.M88I	PPP1R12A_ENST00000437004.2_Missense_Mutation_p.M88I|PPP1R12A_ENST00000546369.1_Start_Codon_SNP_p.M1I|PPP1R12A_ENST00000550107.1_Missense_Mutation_p.M88I|PPP1R12A_ENST00000261207.5_Missense_Mutation_p.M88I	NM_002480.2	NP_002471.1	O14974	MYPT1_HUMAN	protein phosphatase 1, regulatory subunit 12A	88						contractile fiber	protein binding|signal transducer activity			breast(5)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(7)|liver(1)|lung(4)|ovary(2)|skin(1)	29						GAAACTTCACCATATCAACAT	0.333000													12	21					3.07112e-06	3.48243e-06	0.387290	1	0
CAMKV	79012	broad.mit.edu	37	3	49897103	49897103	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr3:49897103C>T	ENST00000477224.1	-	11	1632	c.1154G>A	c.(1153-1155)aGt>aAt	p.S385N	CAMKV_ENST00000296471.7_Missense_Mutation_p.S357N|CAMKV_ENST00000463537.1_Missense_Mutation_p.V317M|CAMKV_ENST00000488336.1_Missense_Mutation_p.S354N|CAMKV_ENST00000467248.1_Missense_Mutation_p.S310N|CAMKV_ENST00000466940.1_Missense_Mutation_p.S311N			Q8NCB2	CAMKV_HUMAN	CaM kinase-like vesicle-associated	385	Ala-rich.					cytoplasmic vesicle membrane|plasma membrane	ATP binding|protein serine/threonine kinase activity			central_nervous_system(1)|large_intestine(2)|lung(2)|ovary(2)	7				BRCA - Breast invasive adenocarcinoma(193;4.62e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.00551)|Kidney(197;0.00621)		TGGGGTGGCACTACGGTCTGC	0.627000													39	62					0	0	0.819951	0	0
GPR83	10888	broad.mit.edu	37	11	94129565	94129565	+	Splice_Site	SNP	C	C	A			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr11:94129565C>A	ENST00000243673.2	-	2	684	c.513_splice	c.e2+1	p.Q171_splice	GPR83_ENST00000539203.2_Intron	NM_016540.3	NP_057624.3	Q9NYM4	GPR83_HUMAN	G protein-coupled receptor 83	171						integral to membrane|plasma membrane	neuropeptide Y receptor activity			NS(1)|breast(1)|central_nervous_system(2)|kidney(2)|large_intestine(2)|lung(9)|ovary(1)|prostate(1)	19		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.0123)				GTGCCCTCACCTGGTGGCGAT	0.547000													23	59					1.96895e-08	2.40439e-08	0.639603	1	0
PAPPA2	60676	broad.mit.edu	37	1	176709310	176709310	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr1:176709310G>T	ENST00000367662.3	+	14	5293	c.4129G>T	c.(4129-4131)Ggg>Tgg	p.G1377W		NM_020318.2	NP_064714.2	Q9BXP8	PAPP2_HUMAN	pappalysin 2	1377					cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding	p.G1377W(1)		NS(3)|breast(3)|central_nervous_system(7)|cervix(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(19)|lung(136)|ovary(7)|pancreas(1)|prostate(4)|skin(10)|upper_aerodigestive_tract(8)|urinary_tract(1)	226						AGAGGACGAGGGGCAGAATCA	0.478000													18	34					6.94344e-10	8.64527e-10	0.539581	1	0
ARID1A	8289	broad.mit.edu	37	1	27106648	27106648	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr1:27106648G>A	ENST00000324856.7	+	20	6630	c.6259G>A	c.(6259-6261)Gga>Aga	p.G2087R	ARID1A_ENST00000540690.1_Missense_Mutation_p.G415R|ARID1A_ENST00000457599.2_Missense_Mutation_p.G1870R|ARID1A_ENST00000374152.2_Missense_Mutation_p.G1704R	NM_006015.4	NP_006006.3	O14497	ARI1A_HUMAN	AT rich interactive domain 1A (SWI-like)	2087					androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding	p.G2087R(1)	ARID1A/MAST2_ENST00000361297(2)	NS(1)|autonomic_ganglia(1)|biliary_tract(1)|breast(13)|central_nervous_system(6)|cervix(2)|endometrium(56)|haematopoietic_and_lymphoid_tissue(8)|kidney(10)|large_intestine(41)|liver(31)|lung(34)|ovary(130)|pancreas(18)|prostate(8)|skin(9)|stomach(14)|upper_aerodigestive_tract(4)|urinary_tract(24)	411		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		TGTCCTGGACGGACTCCTACA	0.592000			"""Mis, N, F, S, D"""		"""clear cell ovarian carcinoma, RCC"""								32	38					0	0	0.740014	0	0
MYLK	4638	broad.mit.edu	37	3	123452802	123452802	+	Silent	SNP	C	C	T			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr3:123452802C>T	ENST00000360772.3	-	11	1419	c.1041G>A	c.(1039-1041)ctG>ctA	p.L347L	MYLK_ENST00000360304.3_Silent_p.L347L|MYLK_ENST00000359169.1_Silent_p.L347L|MYLK_ENST00000346322.5_Silent_p.L347L|MYLK_ENST00000475616.1_Silent_p.L347L			Q15746	MYLK_HUMAN	myosin light chain kinase	347					aorta smooth muscle tissue morphogenesis|muscle contraction	cytosol	actin binding|ATP binding|calmodulin binding|metal ion binding|myosin light chain kinase activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(24)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(17)|lung(37)|ovary(7)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	113		Lung NSC(201;0.0496)		GBM - Glioblastoma multiforme(114;0.0736)		TTGCGGCCTGCAGGGTGATGG	0.632000													36	111					0	0	0.870114	0	0
SULT1C3	442038	broad.mit.edu	37	2	108863744	108863744	+	Missense_Mutation	SNP	T	T	C			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr2:108863744T>C	ENST00000329106.2	+	1	94	c.94T>C	c.(94-96)Tca>Cca	p.S32P	SULT1C3_ENST00000376700.1_Missense_Mutation_p.S32P	NM_001008743.1	NP_001008743.1	Q6IMI6	ST1C3_HUMAN	sulfotransferase family, cytosolic, 1C, member 3	32						cytoplasm	alcohol sulfotransferase activity			breast(1)|kidney(1)|large_intestine(1)|lung(8)|prostate(1)|skin(4)	16						GTTGATATTATCAAAAGAATG	0.393000													31	108					0	0	0.740014	0	0
PUM2	23369	broad.mit.edu	37	2	20483205	20483205	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr2:20483205C>A	ENST00000361078.2	-	10	1356	c.1334G>T	c.(1333-1335)gGt>gTt	p.G445V	PUM2_ENST00000536417.1_Missense_Mutation_p.G389V|PUM2_ENST00000319801.5_Missense_Mutation_p.G445V|PUM2_ENST00000403432.1_Missense_Mutation_p.G445V|PUM2_ENST00000338086.5_Missense_Mutation_p.G445V			Q8TB72	PUM2_HUMAN	pumilio RNA-binding family member 2	445	Ala-rich.				regulation of translation	perinuclear region of cytoplasm|stress granule	protein binding|RNA binding			breast(2)|central_nervous_system(1)|endometrium(6)|kidney(4)|large_intestine(7)|lung(13)|ovary(2)|prostate(4)|urinary_tract(3)	42	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CACTAAGGCACCAGTCTGATC	0.418000													24	60					1.75199e-13	2.31773e-13	0.717897	1	0
SARM1	23098	broad.mit.edu	37	17	26712168	26712168	+	Missense_Mutation	SNP	A	A	T			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr17:26712168A>T	ENST00000457710.3	+	5	1873	c.1402A>T	c.(1402-1404)Acc>Tcc	p.T468S	SARM1_ENST00000379061.4_3'UTR	NM_015077.2	NP_055892.2	Q6SZW1	SARM1_HUMAN	sterile alpha and TIR motif containing 1	502	SAM 1.				innate immune response	cytoplasm|intrinsic to membrane	binding|transmembrane receptor activity			cervix(1)|endometrium(1)|large_intestine(3)|lung(5)|skin(1)|upper_aerodigestive_tract(1)	12	all_lung(13;0.000533)|Lung NSC(42;0.00171)			UCEC - Uterine corpus endometrioid carcinoma (53;0.154)		CCGCCAGTACACCTACGGCCT	0.672000													7	29					0	0	0.248553	0	0
CHSY3	337876	broad.mit.edu	37	5	129520888	129520888	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr5:129520888G>A	ENST00000305031.4	+	3	2411	c.2053G>A	c.(2053-2055)Gaa>Aaa	p.E685K		NM_175856.4	NP_787052.3	Q70JA7	CHSS3_HUMAN	chondroitin sulfate synthase 3	685						Golgi cisterna membrane|integral to membrane	glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity|metal ion binding|N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity			central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(7)|lung(9)|ovary(2)|pancreas(1)|prostate(2)|stomach(1)|urinary_tract(1)	28		all_cancers(142;0.0227)|Breast(839;0.198)|Prostate(80;0.215)|Lung NSC(810;0.239)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	OV - Ovarian serous cystadenocarcinoma(64;0.136)		CCCCAAAGCAGAAATGACCCT	0.438000													20	53					0	0	0.557998	0	0
SGSM2	9905	broad.mit.edu	37	17	2274591	2274591	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr17:2274591C>T	ENST00000268989.3	+	13	1636	c.1459C>T	c.(1459-1461)Ccc>Tcc	p.P487S	SGSM2_ENST00000426855.2_Missense_Mutation_p.P442S|SGSM2_ENST00000574563.1_Missense_Mutation_p.P442S	NM_014853.2	NP_055668.2	O43147	SGSM2_HUMAN	small G protein signaling modulator 2	442						intracellular	Rab GTPase activator activity			biliary_tract(1)|breast(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(2)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	20				Colorectal(2;5.15e-05)|READ - Rectum adenocarcinoma(2;0.000115)		GGGCTTTGGGCCCAGCCTGCC	0.662000													15	25					0	0	0.479597	0	0
APAF1	317	broad.mit.edu	37	12	99042414	99042414	+	Missense_Mutation	SNP	A	A	T			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr12:99042414A>T	ENST00000357310.1	+	3	726	c.149A>T	c.(148-150)cAg>cTg	p.Q50L	APAF1_ENST00000547045.1_Missense_Mutation_p.Q50L|APAF1_ENST00000547743.1_Missense_Mutation_p.Q50L|APAF1_ENST00000550527.1_Missense_Mutation_p.Q50L|APAF1_ENST00000551964.1_Missense_Mutation_p.Q50L|APAF1_ENST00000549007.1_Missense_Mutation_p.Q50L|APAF1_ENST00000339433.3_Missense_Mutation_p.Q50L|APAF1_ENST00000552268.1_Missense_Mutation_p.Q50L|APAF1_ENST00000359972.2_Missense_Mutation_p.Q50L|APAF1_ENST00000333991.1_Missense_Mutation_p.Q50L	NM_181868.1	NP_863658.1	O14727	APAF_HUMAN	apoptotic peptidase activating factor 1	50	CARD.				activation of caspase activity by cytochrome c|defense response|induction of apoptosis by intracellular signals|nervous system development	cytosol|Golgi apparatus|nucleus	ATP binding|caspase activator activity|protein binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(13)|liver(1)|lung(15)|ovary(2)|prostate(2)|skin(1)	42					Adenosine triphosphate(DB00171)	CCCACTCAACAGCAAAGAGCA	0.303000													22	53					0	0	0.608945	0	0
CLIP1	6249	broad.mit.edu	37	12	122826024	122826024	+	Missense_Mutation	SNP	T	T	C			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr12:122826024T>C	ENST00000358808.2	-	10	1848	c.1694A>G	c.(1693-1695)cAt>cGt	p.H565R	CLIP1_ENST00000545889.1_Missense_Mutation_p.H266R|CLIP1_ENST00000540338.1_Missense_Mutation_p.H576R|CLIP1_ENST00000537178.1_Missense_Mutation_p.H530R|CLIP1_ENST00000361654.4_Missense_Mutation_p.H530R|CLIP1_ENST00000302528.7_Missense_Mutation_p.H565R	NM_001247997.1|NM_002956.2	NP_001234926.1|NP_002947.1	P30622	CLIP1_HUMAN	CAP-GLY domain containing linker protein 1	576					mitotic prometaphase|positive regulation of microtubule polymerization	centrosome|cytosol|endosome|intermediate filament|kinetochore	nucleic acid binding|protein homodimerization activity|zinc ion binding			NS(1)|breast(5)|endometrium(4)|kidney(5)|large_intestine(16)|liver(1)|lung(21)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	60	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.81e-05)|Epithelial(86;6.85e-05)|BRCA - Breast invasive adenocarcinoma(302;0.226)		GGCTCCAAAATGCTCCTTCAG	0.443000													51	270					0	0	0.870114	0	0
APOH	350	broad.mit.edu	37	17	64208278	64208278	+	Silent	SNP	A	A	C			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr17:64208278A>C	ENST00000205948.6	-	8	1048	c.1011T>G	c.(1009-1011)acT>acG	p.T337T		NM_000042.2	NP_000033.2	P02749	APOH_HUMAN	apolipoprotein H (beta-2-glycoprotein I)	337	Sushi-like.				blood coagulation, intrinsic pathway|negative regulation of angiogenesis|negative regulation of blood coagulation|negative regulation of endothelial cell migration|negative regulation of endothelial cell proliferation|negative regulation of fibrinolysis|negative regulation of myeloid cell apoptosis|negative regulation of smooth muscle cell apoptosis|plasminogen activation|positive regulation of lipoprotein lipase activity|triglyceride metabolic process|triglyceride transport	cell surface|chylomicron|high-density lipoprotein particle|very-low-density lipoprotein particle	eukaryotic cell surface binding|glycoprotein binding|heparin binding|lipoprotein lipase activator activity|phospholipid binding			central_nervous_system(1)|kidney(3)|large_intestine(5)|lung(6)|skin(1)|upper_aerodigestive_tract(1)	17			BRCA - Breast invasive adenocarcinoma(6;9.74e-08)			CGGATGCATCAGTTTTCCAAA	0.358000													9	65					0	0	0.307466	0	0
FN3KRP	79672	broad.mit.edu	37	17	80676808	80676808	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr17:80676808G>T	ENST00000269373.6	+	2	241	c.168G>T	c.(166-168)atG>atT	p.M56I	FN3KRP_ENST00000535965.1_Missense_Mutation_p.M6I	NM_024619.3	NP_078895.2	Q9HA64	KT3K_HUMAN	fructosamine 3 kinase related protein	56							kinase activity			breast(1)|large_intestine(2)|lung(1)|ovary(2)|upper_aerodigestive_tract(1)	7	Breast(20;0.000523)|all_neural(118;0.0952)		BRCA - Breast invasive adenocarcinoma(99;0.0344)|OV - Ovarian serous cystadenocarcinoma(97;0.061)			AAGGTGAGATGGCAAGTTTAA	0.502000													51	88					2.59344e-38	3.80772e-38	0.870114	1	0
PCDHGC4	56098	broad.mit.edu	37	5	140865903	140865903	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr5:140865903G>A	ENST00000306593.1	+	1	1163	c.1163G>A	c.(1162-1164)cGc>cAc	p.R388H	PCDHGA3_ENST00000253812.6_Intron|PCDHGA6_ENST00000517434.1_Intron|PCDHGB3_ENST00000576222.1_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGB4_ENST00000519479.1_Intron|PCDHGA7_ENST00000518325.1_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGA9_ENST00000573521.1_Intron|PCDHGA11_ENST00000518882.1_Intron|PCDHGA11_ENST00000398587.2_Intron|PCDHGB7_ENST00000398594.2_Intron|PCDHGA8_ENST00000398604.2_Intron|PCDHGB6_ENST00000520790.1_Intron|PCDHGA10_ENST00000398610.2_Intron|PCDHGC3_ENST00000308177.3_Intron|PCDHGA12_ENST00000252085.3_Intron	NM_018928.2|NM_032406.1	NP_061751.1|NP_115782.1														NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(13)|lung(13)|ovary(5)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	42			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GTGAGCCTCCGCATTCCTGAC	0.557000													15	46					0	0	0.479597	0	0
TTN	7273	broad.mit.edu	37	2	179451529	179451529	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr2:179451529G>T	ENST00000589042.1	-	308	64323	c.64099C>A	c.(64099-64101)Ccg>Acg	p.P21367T	TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.P12494T|TTN_ENST00000460472.2_Missense_Mutation_p.P12302T|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.P18799T|TTN-AS1_ENST00000456053.1_RNA|TTN-AS1_ENST00000589907.1_RNA|TTN-AS1_ENST00000590743.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.P12427T|TTN-AS1_ENST00000590932.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.P19726T|TTN-AS1_ENST00000419746.1_RNA|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000592630.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	19726	Ig-like 113.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GGGGGATCCGGCTCACCTAGA	0.413000													24	83					4.4004e-07	5.10366e-07	0.654019	1	0
CCDC148	130940	broad.mit.edu	37	2	159170350	159170350	+	Missense_Mutation	SNP	T	T	C			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr2:159170350T>C	ENST00000283233.5	-	8	1134	c.821A>G	c.(820-822)tAc>tGc	p.Y274C	CCDC148_ENST00000536771.1_Missense_Mutation_p.Y188C|CCDC148_ENST00000409187.1_Missense_Mutation_p.Y283C	NM_138803.3	NP_620158.3	Q8NFR7	CC148_HUMAN	coiled-coil domain containing 148	274										endometrium(2)|kidney(2)|large_intestine(6)|lung(9)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	23						ATCTCCAGGGTACTGATCCAA	0.393000													24	52					0	0	0.667858	0	0
OR5D13	390142	broad.mit.edu	37	11	55541676	55541676	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr11:55541676G>C	ENST00000361760.1	+	1	763	c.763G>C	c.(763-765)Gga>Cga	p.G255R		NM_001001967.1	NP_001001967.1	Q8NGL4	OR5DD_HUMAN	olfactory receptor, family 5, subfamily D, member 13	255					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|liver(1)|lung(20)|ovary(1)|pancreas(2)|skin(2)|stomach(1)|urinary_tract(1)	40		all_epithelial(135;0.196)				TATCTTCCATGGAACTATCCT	0.443000													23	52					0	0	0.624587	0	0
DSTN	11034	broad.mit.edu	37	20	17581671	17581671	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr20:17581671G>C	ENST00000246069.6	+	2	638	c.292G>C	c.(292-294)Gag>Cag	p.E98Q	DSTN_ENST00000543261.1_Missense_Mutation_p.E81Q|DSTN_ENST00000474024.1_3'UTR	NM_006870.3	NP_006861.1	P60981	DEST_HUMAN	destrin (actin depolymerizing factor)	98	ADF-H.				actin filament severing|actin polymerization or depolymerization		actin binding			endometrium(1)|large_intestine(5)|lung(8)|skin(1)	15						CAGAAAAGAAGAGTTGATGTT	0.368000													17	78					0	0	0.520397	0	0
IMPDH1	3614	broad.mit.edu	37	7	128040196	128040196	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr7:128040196C>A	ENST00000338791.6	-	9	1177	c.827G>T	c.(826-828)gGt>gTt	p.G276V	IMPDH1_ENST00000343214.4_Missense_Mutation_p.G166V|IMPDH1_ENST00000480861.1_Missense_Mutation_p.G186V|IMPDH1_ENST00000419067.2_Missense_Mutation_p.G243V|IMPDH1_ENST00000378717.4_Missense_Mutation_p.G207V|IMPDH1_ENST00000354269.5_Missense_Mutation_p.G266V|IMPDH1_ENST00000496200.1_Missense_Mutation_p.G166V|IMPDH1_ENST00000348127.6_Missense_Mutation_p.G240V|IMPDH1_ENST00000470772.1_Missense_Mutation_p.G190V	NM_000883.3	NP_000874.2	P20839	IMDH1_HUMAN	IMP (inosine 5'-monophosphate) dehydrogenase 1	191					GMP biosynthetic process|purine base metabolic process	cytosol|nucleus	DNA binding|IMP dehydrogenase activity|metal ion binding			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(10)|ovary(1)|skin(3)	22					Mycophenolate mofetil(DB00688)|Mycophenolic acid(DB01024)|NADH(DB00157)|Ribavirin(DB00811)|Thioguanine(DB00352)	CAACGTCACACCTGCTGGAGC	0.562000													44	179					4.64027e-19	6.44059e-19	0.870114	1	0
LHCGR	3973	broad.mit.edu	37	2	48950765	48950765	+	Missense_Mutation	SNP	T	T	C			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr2:48950765T>C	ENST00000294954.7	-	5	475	c.454A>G	c.(454-456)Att>Gtt	p.I152V	STON1-GTF2A1L_ENST00000402114.2_Intron|LHCGR_ENST00000405626.1_Missense_Mutation_p.I152V|LHCGR_ENST00000401907.1_Missense_Mutation_p.I152V|LHCGR_ENST00000344775.3_Missense_Mutation_p.I152V|LHCGR_ENST00000403273.1_Missense_Mutation_p.I152V	NM_000233.3	NP_000224.2	P22888	LSHR_HUMAN	luteinizing hormone/choriogonadotropin receptor	152			I -> T (in LHR; reveals a marked impairment of human chorionic gonadotropin binding and signal transduction).		male genitalia development|male gonad development	endosome|integral to plasma membrane	luteinizing hormone receptor activity			NS(1)|breast(6)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(5)|liver(1)|lung(23)|ovary(3)|pancreas(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)	56		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.176)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)		Cetrorelix(DB00050)|Choriogonadotropin alfa(DB00097)|Goserelin(DB00014)|Lutropin alfa(DB00044)|Menotropins(DB00032)	ACTTACAGAATGAAATTTGAT	0.383000													28	81					0	0	0.740014	0	0
TRIM27	5987	broad.mit.edu	37	6	28872087	28872087	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr6:28872087C>A	ENST00000377199.3	-	8	1658	c.1302G>T	c.(1300-1302)caG>caT	p.Q434H	TRIM27_ENST00000377194.3_Intron	NM_006510.4	NP_006501.1	P14373	TRI27_HUMAN	tripartite motif containing 27	434	B30.2/SPRY.				cell proliferation|negative regulation of gene expression, epigenetic|negative regulation of transcription from RNA polymerase II promoter|protein trimerization|spermatogenesis|transcription, DNA-dependent	cytoplasm|integral to plasma membrane|membrane fraction|nuclear membrane|PML body	DNA binding|protein binding|transmembrane receptor protein tyrosine kinase activity|zinc ion binding			endometrium(1)|large_intestine(2)|lung(6)|ovary(1)	10						TCCCCACCCGCTGGAGCGGGG	0.532000			T	RET	papillary thyroid								44	112					5.37117e-13	7.0688e-13	0.870114	1	0
PCDHB13	56123	broad.mit.edu	37	5	140594323	140594323	+	Missense_Mutation	SNP	A	A	T			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr5:140594323A>T	ENST00000341948.4	+	1	815	c.628A>T	c.(628-630)Agg>Tgg	p.R210W		NM_018933.2	NP_061756.1	Q9Y5F0	PCDBD_HUMAN		210	Cadherin 2.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			NS(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(14)|liver(4)|lung(24)|ovary(5)|pancreas(1)|skin(4)|upper_aerodigestive_tract(1)	66			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			AGCTGAGCTCAGGTTAACACT	0.547000													7	57					0	0	0.278610	0	0
ADAM21P1	145241	broad.mit.edu	37	14	70713288	70713288	+	RNA	SNP	T	T	A			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr14:70713288T>A	ENST00000530196.1	-	0	1230					NR_003951.1																						GTATTCATGATGCAACCTCTT	0.428000													45	208					0	0	0.864702	0	0
SSTR1	6751	broad.mit.edu	37	14	38679155	38679155	+	Silent	SNP	C	C	T			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr14:38679155C>T	ENST00000267377.2	+	3	1178	c.561C>T	c.(559-561)ctC>ctT	p.L187L		NM_001049.2	NP_001040.1	P30872	SSR1_HUMAN	somatostatin receptor 1	187					digestion|G-protein signaling, coupled to cyclic nucleotide second messenger|negative regulation of cell proliferation|response to nutrient	integral to plasma membrane	somatostatin receptor activity			breast(1)|central_nervous_system(3)|endometrium(6)|kidney(1)|large_intestine(6)|lung(8)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	29	Hepatocellular(127;0.213)|Esophageal squamous(585;0.22)		Lung(238;3.93e-06)|LUAD - Lung adenocarcinoma(48;2.62e-05)|Epithelial(34;0.187)	GBM - Glioblastoma multiforme(112;0.00444)	Octreotide(DB00104)	TATCGCTGCTCGTCATCCTGC	0.662000													10	38					0	0	0.387290	0	0
DDHD1	80821	broad.mit.edu	37	14	53529739	53529739	+	Missense_Mutation	SNP	T	T	G			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr14:53529739T>G	ENST00000357758.3	-	7	1871	c.1688A>C	c.(1687-1689)gAa>gCa	p.E563A	DDHD1_ENST00000323669.5_Missense_Mutation_p.E563A|DDHD1_ENST00000395606.1_Missense_Mutation_p.E570A	NM_030637.2	NP_085140.2	Q8NEL9	DDHD1_HUMAN	DDHD domain containing 1	563					lipid catabolic process	cytoplasm	hydrolase activity|metal ion binding			breast(2)|cervix(1)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(4)|lung(11)|ovary(3)|prostate(1)	25	Breast(41;0.037)					CAACTCTTCTTCCTTTTGCAG	0.383000													48	114					0	0	0.870114	0	0
PIGS	94005	broad.mit.edu	37	17	26888589	26888589	+	Missense_Mutation	SNP	C	C	T	rs138187632		TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr17:26888589C>T	ENST00000308360.7	-	6	902	c.527G>A	c.(526-528)cGg>cAg	p.R176Q	PIGS_ENST00000395346.2_Missense_Mutation_p.R168Q|PIGS_ENST00000543734.1_Missense_Mutation_p.R115Q|PIGS_ENST00000465444.1_5'UTR	NM_033198.3	NP_149975.1	Q96S52	PIGS_HUMAN	phosphatidylinositol glycan anchor biosynthesis, class S	176					attachment of GPI anchor to protein|C-terminal protein lipidation	GPI-anchor transamidase complex	protein binding			breast(3)|endometrium(1)|kidney(1)|large_intestine(2)|lung(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	16	Lung NSC(42;0.00431)					AAAGGCCTCCCGGTGCATTAT	0.572000													11	17					0	0	0.387290	0	0
NAV2	89797	broad.mit.edu	37	11	20113762	20113762	+	Missense_Mutation	SNP	A	A	G			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr11:20113762A>G	ENST00000396085.1	+	29	6033	c.5672A>G	c.(5671-5673)gAg>gGg	p.E1891G	NAV2_ENST00000396087.3_Missense_Mutation_p.E1947G|NAV2_ENST00000360655.4_Missense_Mutation_p.E1824G|NAV2_ENST00000349880.4_Missense_Mutation_p.E1888G|NAV2_ENST00000540292.1_Missense_Mutation_p.E1878G|NAV2_ENST00000311043.8_Missense_Mutation_p.E952G|NAV2_ENST00000533917.1_Missense_Mutation_p.E952G|NAV2_ENST00000527559.2_Missense_Mutation_p.E1876G	NM_182964.5	NP_892009.3	Q8IVL1	NAV2_HUMAN	neuron navigator 2	1947						nucleus	ATP binding|helicase activity			NS(1)|breast(2)|central_nervous_system(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(26)|lung(38)|ovary(3)|pancreas(1)|prostate(7)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	116						AGTGAAATAGAGAAGCTGAAA	0.498000													33	69					0	0	0.779181	0	0
ROCK2	9475	broad.mit.edu	37	2	11355773	11355773	+	Splice_Site	SNP	T	T	G			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr2:11355773T>G	ENST00000315872.6	-	14	1910		c.e14-2		ROCK2_ENST00000401753.1_Splice_Site	NM_004850.3	NP_004841.2	O75116	ROCK2_HUMAN	Rho-associated, coiled-coil containing protein kinase 2						axon guidance|cytokinesis|intracellular signal transduction	cytosol|plasma membrane	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|structural molecule activity			breast(2)|central_nervous_system(1)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(6)|lung(10)|prostate(1)|skin(4)|stomach(3)|urinary_tract(2)	43	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.137)|OV - Ovarian serous cystadenocarcinoma(76;0.162)		TAAGGTAATCTGAAATAATGC	0.299000													11	30					0	0	0.361761	0	0
TBX3	6926	broad.mit.edu	37	12	115114207	115114207	+	Missense_Mutation	SNP	T	T	C			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr12:115114207T>C	ENST00000349155.2	-	5	1913	c.950A>G	c.(949-951)gAt>gGt	p.D317G	TBX3_ENST00000257566.3_Missense_Mutation_p.D337G	NM_005996.3	NP_005987.3	O15119	TBX3_HUMAN	T-box 3	337					anterior/posterior axis specification, embryo|anti-apoptosis|cell aging|embryonic arm morphogenesis|embryonic digit morphogenesis|female genitalia development|follicle-stimulating hormone secretion|luteinizing hormone secretion|male genitalia development|mesoderm morphogenesis|negative regulation of myoblast differentiation|negative regulation of transcription, DNA-dependent|positive regulation of cell cycle|positive regulation of cell proliferation|regulation of transcription from RNA polymerase II promoter|skeletal system development	nucleus	sequence-specific DNA binding			breast(5)|endometrium(1)|kidney(1)|large_intestine(6)|lung(21)|ovary(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	47	Medulloblastoma(191;0.163)|all_neural(191;0.178)			BRCA - Breast invasive adenocarcinoma(302;0.0574)		GGAGGACTCATCAGAGGTCCC	0.512000													35	67					0	0	0.804634	0	0
SLC8A3	6547	broad.mit.edu	37	14	70634960	70634960	+	Silent	SNP	C	C	A			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr14:70634960C>A	ENST00000381269.2	-	2	933	c.180G>T	c.(178-180)ctG>ctT	p.L60L	SLC8A3_ENST00000528359.1_Silent_p.L60L|SLC8A3_ENST00000534137.1_Silent_p.L60L|SLC8A3_ENST00000356921.2_Silent_p.L60L|SLC8A3_ENST00000357887.3_Silent_p.L60L	NM_058240.2|NM_183002.1	NP_489479.1|NP_892114.1	P57103	NAC3_HUMAN	solute carrier family 8 (sodium/calcium exchanger), member 3	60					cell communication|platelet activation	integral to membrane|plasma membrane	calcium:sodium antiporter activity|calmodulin binding			NS(1)|breast(3)|central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(12)|lung(18)|ovary(2)|pancreas(2)|prostate(3)|skin(6)	54				BRCA - Breast invasive adenocarcinoma(234;0.0079)|all cancers(60;0.0102)|OV - Ovarian serous cystadenocarcinoma(108;0.0555)		ACCAGATTGGCAGGATGACAC	0.552000													13	24					0.000151284	0.000160779	0.435327	1	0
CROT	54677	broad.mit.edu	37	7	87022269	87022269	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr7:87022269G>T	ENST00000331536.3	+	17	1789	c.1604G>T	c.(1603-1605)gGa>gTa	p.G535V	CROT_ENST00000442291.1_Missense_Mutation_p.G535V|CROT_ENST00000419147.2_Missense_Mutation_p.G563V	NM_021151.3	NP_066974.2	Q9UKG9	OCTC_HUMAN	carnitine O-octanoyltransferase	535	Poly-Gly.				fatty acid beta-oxidation using acyl-CoA oxidase|generation of precursor metabolites and energy|transport	peroxisomal matrix	carnitine O-octanoyltransferase activity			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(21)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	37	Esophageal squamous(14;0.0058)|all_lung(186;0.201)|Lung NSC(181;0.203)				L-Carnitine(DB00583)	CACAGCGGAGGAGGTGGAAAT	0.383000													39	154					1.96642e-18	2.71451e-18	0.827153	1	0
MTMR11	10903	broad.mit.edu	37	1	149906417	149906417	+	Silent	SNP	C	C	A			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr1:149906417C>A	ENST00000439741.2	-	6	721	c.471G>T	c.(469-471)gtG>gtT	p.V157V	MTMR11_ENST00000369140.3_Silent_p.V85V|MTMR11_ENST00000406732.3_Silent_p.V129V|MTMR11_ENST00000492824.1_5'UTR|MTMR11_ENST00000361405.6_Silent_p.V157V	NM_001145862.1	NP_001139334.1	A4FU01	MTMRB_HUMAN	myotubularin related protein 11	157							phosphatase activity			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(3)|lung(13)|prostate(2)|stomach(1)|urinary_tract(4)	34	Breast(34;0.0009)|Ovarian(49;0.0377)|all_hematologic(923;0.0597)|Hepatocellular(266;0.161)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.221)|STAD - Stomach adenocarcinoma(528;0.247)			TGGCCATGGTCACCTGCAGAG	0.493000													15	49					1.49906e-05	1.64121e-05	0.457914	1	0
PCOLCE2	26577	broad.mit.edu	37	3	142542444	142542444	+	Silent	SNP	G	G	A			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr3:142542444G>A	ENST00000295992.3	-	7	1185	c.879C>T	c.(877-879)acC>acT	p.T293T	PCOLCE2_ENST00000485766.1_Intron	NM_013363.3	NP_037495.1	Q9UKZ9	PCOC2_HUMAN	procollagen C-endopeptidase enhancer 2	293						extracellular region	collagen binding|heparin binding|peptidase activator activity			NS(1)|endometrium(1)|large_intestine(11)|lung(15)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	32						ACAAGGCCACGGTGGGTTTTA	0.363000													24	56					0	0	0.654019	0	0
F5	2153	broad.mit.edu	37	1	169511240	169511240	+	Nonsense_Mutation	SNP	G	G	A			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr1:169511240G>A	ENST00000367796.3	-	13	3304	c.3103C>T	c.(3103-3105)Cga>Tga	p.R1035*	F5_ENST00000367797.3_Nonsense_Mutation_p.R1030*			P12259	FA5_HUMAN	coagulation factor V (proaccelerin, labile factor)	1030	B.				cell adhesion|platelet activation|platelet degranulation	plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity			NS(1)|breast(4)|central_nervous_system(4)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(24)|lung(55)|ovary(3)|prostate(4)|skin(5)|stomach(1)|upper_aerodigestive_tract(7)|urinary_tract(1)	128	all_hematologic(923;0.208)				Drotrecogin alfa(DB00055)	TTCTTTTTTCGTGTCTTAATG	0.408000													103	200					0	0	0.870114	0	0
UNK	85451	broad.mit.edu	37	17	73780814	73780814	+	Silent	SNP	C	C	T			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr17:73780814C>T	ENST00000293218.3	+	2	81	c.81C>T	c.(79-81)gaC>gaT	p.D27D	H3F3B_ENST00000586607.1_Intron			Q9C0B0	UNK_HUMAN	unkempt family zinc finger	0							nucleic acid binding|zinc ion binding	p.D27E(2)		cervix(3)|endometrium(8)|kidney(2)|large_intestine(5)|lung(3)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)	25			all cancers(21;2.61e-06)|Epithelial(20;7.39e-06)|BRCA - Breast invasive adenocarcinoma(9;0.00194)|LUSC - Lung squamous cell carcinoma(166;0.154)			TCCAGCCGGACATAGAACCAC	0.642000													11	22					0	0	0.435327	0	0
FAM111A	63901	broad.mit.edu	37	11	58920495	58920495	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr11:58920495G>T	ENST00000528737.1	+	5	4172	c.1354G>T	c.(1354-1356)Gta>Tta	p.V452L	FAM111A_ENST00000531147.1_Missense_Mutation_p.V452L|FAM111A_ENST00000420244.1_Missense_Mutation_p.V452L|FAM111A_ENST00000533703.1_Missense_Mutation_p.V452L|FAM111A_ENST00000361723.3_Missense_Mutation_p.V452L			Q96PZ2	F111A_HUMAN	family with sequence similarity 111, member A	452					proteolysis		serine-type endopeptidase activity			breast(2)|endometrium(2)|kidney(1)|large_intestine(5)|lung(5)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	22		all_epithelial(135;0.139)				TGGACAACAAGTACCTATGGA	0.368000													18	65					3.52763e-06	3.96468e-06	0.520397	1	0
AK9	221264	broad.mit.edu	37	6	109871392	109871392	+	Silent	SNP	G	G	A	rs138836954		TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr6:109871392G>A	ENST00000424296.2	-	25	2941	c.2865C>T	c.(2863-2865)gcC>gcT	p.A955A	AK9_ENST00000341338.6_Silent_p.A34A|AK9_ENST00000355283.1_Silent_p.A34A	NM_001145128.2	NP_001138600.2			adenylate kinase 9																		CTCGATACTTGGCTGCTTCTT	0.428000													42	69					0	0	0.827153	0	0
BTBD3	22903	broad.mit.edu	37	20	11900381	11900381	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr20:11900381G>T	ENST00000405977.1	+	4	1058	c.433G>T	c.(433-435)Ggg>Tgg	p.G145W	BTBD3_ENST00000378226.2_Missense_Mutation_p.G145W|BTBD3_ENST00000488503.1_3'UTR|BTBD3_ENST00000254977.3_Missense_Mutation_p.G84W|BTBD3_ENST00000399006.2_Missense_Mutation_p.G84W			Q9Y2F9	BTBD3_HUMAN	BTB (POZ) domain containing 3	145	BTB.									breast(2)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(2)|lung(18)|ovary(3)|skin(2)	34						TTTAGCTGTTGGGAGCTCTGT	0.408000													29	79					1.75199e-13	2.31773e-13	0.717897	1	0
OR2A25	392138	broad.mit.edu	37	7	143771421	143771421	+	Missense_Mutation	SNP	A	A	C			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr7:143771421A>C	ENST00000408898.2	+	1	147	c.109A>C	c.(109-111)Att>Ctt	p.I37L		NM_001004488.1	NP_001004488.1	A4D2G3	O2A25_HUMAN	olfactory receptor, family 2, subfamily A, member 25	37					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(16)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(1)	24	Melanoma(164;0.0783)					CTACATCTTCATTCTGTTGGG	0.522000													35	78					0	0	0.769981	0	0
OR10G7	390265	broad.mit.edu	37	11	123909361	123909361	+	Silent	SNP	G	G	A			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr11:123909361G>A	ENST00000330487.5	-	1	356	c.348C>T	c.(346-348)gtC>gtT	p.V116V		NM_001004463.1	NP_001004463.1	Q8NGN6	O10G7_HUMAN	olfactory receptor, family 10, subfamily G, member 7	116					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(7)|large_intestine(6)|lung(20)|ovary(2)|prostate(2)|stomach(3)|urinary_tract(1)	47		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0521)		CATAGGACATGACTGTGTAGA	0.572000													48	99					0	0	0.870114	0	0
NOS2	4843	broad.mit.edu	37	17	26086080	26086080	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr17:26086080G>A	ENST00000313735.6	-	26	3414	c.3181C>T	c.(3181-3183)Cgg>Tgg	p.R1061W		NM_000625.4	NP_000616.3	P35228	NOS2_HUMAN	nitric oxide synthase 2, inducible	1061					arginine catabolic process|defense response to Gram-negative bacterium|innate immune response in mucosa|nitric oxide biosynthetic process|peptidyl-cysteine S-nitrosylation|platelet activation|positive regulation of killing of cells of other organism|positive regulation of leukocyte mediated cytotoxicity|regulation of cellular respiration|regulation of insulin secretion|superoxide metabolic process	cytosol|nucleus	arginine binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|protein homodimerization activity|tetrahydrobiopterin binding			autonomic_ganglia(1)|breast(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(8)|lung(28)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	56					Dexamethasone(DB01234)|Hydrocortisone(DB00741)|L-Arginine(DB00125)|L-Citrulline(DB00155)	AGCTGCTGCCGCAGGATGTCC	0.622000													8	17					0	0	0.307466	0	0
EDAR	10913	broad.mit.edu	37	2	109547447	109547447	+	Silent	SNP	C	C	G			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr2:109547447C>G	ENST00000409271.1	-	3	467	c.24G>C	c.(22-24)acG>acC	p.T8T	EDAR_ENST00000258443.2_Silent_p.T8T|EDAR_ENST00000376651.1_Silent_p.T8T			Q9UNE0	EDAR_HUMAN	ectodysplasin A receptor	8					apoptosis|cell differentiation	integral to membrane	protein binding|transmembrane receptor activity			NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(3)|lung(6)|prostate(1)|skin(1)	16						AGGGCGTCTGCGTGCAGTCCC	0.627000													30	92					0	0	0.750413	0	0
GOLGA6L6	727832	broad.mit.edu	37	15	20743796	20743796	+	Silent	SNP	C	C	T			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr15:20743796C>T	ENST00000427390.2	-	4	498	c.408G>A	c.(406-408)acG>acA	p.T136T		NM_001145004.1	NP_001138476.1	A8MZA4	GG6L6_HUMAN	golgin A6 family-like 6	136								p.T136T(1)		NS(3)|endometrium(4)|kidney(1)|skin(3)	11						TTTTCTGACACGTAAGGATTC	0.493000													4	47					0	0	0.150653	0	0
BAG3	9531	broad.mit.edu	37	10	121431866	121431866	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr10:121431866C>T	ENST00000369085.3	+	3	913	c.607C>T	c.(607-609)Cgg>Tgg	p.R203W		NM_004281.3	NP_004272.2	O95817	BAG3_HUMAN	BCL2-associated athanogene 3	203					anti-apoptosis|apoptosis|protein folding	cytosol				endometrium(3)|kidney(1)|large_intestine(3)|liver(2)|lung(5)|ovary(2)|prostate(1)|skin(2)|urinary_tract(1)	20		Lung NSC(174;0.109)|all_lung(145;0.142)		all cancers(201;0.00187)|BRCA - Breast invasive adenocarcinoma(275;0.148)		CCAGCTCCCGCGGGGGTACAT	0.652000													14	67					0	0	0.435327	0	0
PMS2P4	5382	broad.mit.edu	37	7	66764327	66764327	+	RNA	SNP	G	G	C			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr7:66764327G>C	ENST00000414507.1	-	0	128																											TCACCGCAGTGCTTAGACTCA	0.453000													106	301					0	0	0.870114	0	0
SLC12A7	10723	broad.mit.edu	37	5	1065452	1065452	+	Missense_Mutation	SNP	A	A	T			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr5:1065452A>T	ENST00000264930.5	-	18	2426	c.2383T>A	c.(2383-2385)Tgg>Agg	p.W795R		NM_006598.2	NP_006589.2	Q9Y666	S12A7_HUMAN	solute carrier family 12 (potassium/chloride transporter), member 7	795					potassium ion transport|sodium ion transport	integral to plasma membrane	potassium:chloride symporter activity			breast(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(14)|ovary(2)|prostate(1)|skin(4)|urinary_tract(2)	32	Lung NSC(6;2.47e-13)|all_lung(6;1.67e-12)|all_epithelial(6;5.44e-09)		Epithelial(17;0.000497)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|all cancers(22;0.00241)|Lung(60;0.165)		Potassium Chloride(DB00761)	GATGCGGGCCAGGCCATGAGC	0.657000													24	57					0	0	0.624587	0	0
COL6A2	1292	broad.mit.edu	37	21	47546443	47546443	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr21:47546443C>T	ENST00000300527.4	+	27	2553	c.2449C>T	c.(2449-2451)Ccc>Tcc	p.P817S	COL6A2_ENST00000397763.1_Missense_Mutation_p.P817S|COL6A2_ENST00000357838.4_Missense_Mutation_p.P817S|COL6A2_ENST00000409416.1_Missense_Mutation_p.P817S|COL6A2_ENST00000310645.5_Missense_Mutation_p.P817S	NM_001849.3	NP_001840.3	P12110	CO6A2_HUMAN	collagen, type VI, alpha 2	817	Nonhelical region.				axon guidance|cell-cell adhesion|extracellular matrix organization|protein heterotrimerization	collagen|extracellular space|protein complex	extracellular matrix structural constituent|protein binding, bridging			NS(1)|breast(1)|central_nervous_system(7)|endometrium(7)|kidney(5)|liver(1)|lung(15)|ovary(2)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	43	Breast(49;0.245)			Colorectal(79;0.0303)|READ - Rectum adenocarcinoma(84;0.0649)		CCCAGACCTTCCCTGCCAAAC	0.652000													91	71					0	0	0.870114	0	0
ASB2	51676	broad.mit.edu	37	14	94417386	94417386	+	Missense_Mutation	SNP	T	T	C			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr14:94417386T>C	ENST00000555019.1	-	6	1269	c.839A>G	c.(838-840)cAg>cGg	p.Q280R	ASB2_ENST00000556337.1_Intron|ASB2_ENST00000315988.4_Missense_Mutation_p.Q232R	NM_001202429.1	NP_001189358.1	Q96Q27	ASB2_HUMAN	ankyrin repeat and SOCS box containing 2	232					intracellular signal transduction					breast(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(8)|ovary(2)|pancreas(1)|prostate(3)|skin(1)|soft_tissue(1)|urinary_tract(1)	27		all_cancers(154;0.13)		COAD - Colon adenocarcinoma(157;0.217)|Epithelial(152;0.232)		CTGTCCACTCTGGGCGGCCAC	0.587000													82	199					0	0	0.870114	0	0
PARP10	84875	broad.mit.edu	37	8	145057451	145057451	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr8:145057451G>A	ENST00000313028.7	-	8	2400	c.2306C>T	c.(2305-2307)aCc>aTc	p.T769I	PARP10_ENST00000524918.1_Missense_Mutation_p.T760I|PARP10_ENST00000525773.1_Missense_Mutation_p.T781I	NM_032789.3	NP_116178.2	Q53GL7	PAR10_HUMAN	poly (ADP-ribose) polymerase family, member 10	769	Myc binding.					Golgi apparatus|nucleolus	NAD+ ADP-ribosyltransferase activity|nucleotide binding			NS(1)|breast(2)|endometrium(2)|kidney(1)|large_intestine(5)|lung(9)|ovary(4)|pancreas(1)|upper_aerodigestive_tract(2)	27	all_cancers(97;8.2e-11)|all_epithelial(106;1.1e-09)|Lung NSC(106;5.89e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.31e-40)|Epithelial(56;1.16e-39)|all cancers(56;6.43e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			ACGGAGGATGGTGCAGTCACC	0.682000													5	19					0	0	0.184627	0	0
OR2G2	81470	broad.mit.edu	37	1	247752427	247752427	+	Nonsense_Mutation	SNP	G	G	T			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr1:247752427G>T	ENST00000320065.1	+	1	766	c.766G>T	c.(766-768)Gga>Tga	p.G256*	RP11-978I15.10_ENST00000435333.1_RNA|RP11-978I15.10_ENST00000446347.1_RNA	NM_001001915.1	NP_001001915.1	Q8NGZ5	OR2G2_HUMAN	olfactory receptor, family 2, subfamily G, member 2	256					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(4)|kidney(4)|large_intestine(3)|lung(30)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	45	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.017)			catcttttatggaaccatcat	0.493000													57	82					3.53049e-34	5.12425e-34	0.870114	1	0
LRRC49	54839	broad.mit.edu	37	15	71185957	71185957	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr15:71185957C>T	ENST00000260382.5	+	2	343	c.83C>T	c.(82-84)tCa>tTa	p.S28L	LRRC49_ENST00000560369.1_Missense_Mutation_p.S28L|LRRC49_ENST00000443425.2_5'UTR|LRRC49_ENST00000544974.2_Missense_Mutation_p.S18L	NM_001199017.1|NM_017691.3	NP_001185946.1|NP_060161.2	Q8IUZ0	LRC49_HUMAN	leucine rich repeat containing 49	28						cytoplasm|microtubule				breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(6)|lung(14)|ovary(2)|prostate(3)|skin(3)	34						ATTCAAACATCATCGCTTCCT	0.294000													12	47					0	0	0.457914	0	0
KGFLP2	654466	broad.mit.edu	37	9	41962602	41962602	+	RNA	SNP	G	G	T			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr9:41962602G>T	ENST00000454645.1	-	0	902					NR_003670.1																						TTCTTTCTTTGTTTTTTTTCC	0.373000													6	44					1.12685e-05	1.23905e-05	0.307466	1	0
KDM5C	8242	broad.mit.edu	37	X	53228025	53228025	+	Silent	SNP	C	C	A			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chrX:53228025C>A	ENST00000452825.3	-	14	2620	c.2088G>T	c.(2086-2088)ctG>ctT	p.L696L	KDM5C_ENST00000375379.3_Silent_p.L763L|KDM5C_ENST00000375383.3_Silent_p.L722L|KDM5C_ENST00000375401.3_Silent_p.L763L|KDM5C_ENST00000404049.3_Silent_p.L762L	NM_001146702.1	NP_001140174.1	P41229	KDM5C_HUMAN	lysine (K)-specific demethylase 5C	763					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|zinc ion binding			autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(30)|large_intestine(9)|lung(17)|oesophagus(1)|ovary(6)|prostate(1)|salivary_gland(1)|skin(1)|upper_aerodigestive_tract(2)	82						CCCGAACCTTCAGCTTATGCA	0.587000			"""N, F, S"""		clear cell renal carcinoma								9	56					3.09899e-07	3.61074e-07	0.307466	1	0
ATP8B4	79895	broad.mit.edu	37	15	50339591	50339591	+	Missense_Mutation	SNP	T	T	C			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr15:50339591T>C	ENST00000284509.6	-	4	299	c.158A>G	c.(157-159)cAa>cGa	p.Q53R	ATP8B4_ENST00000559829.1_Missense_Mutation_p.Q53R	NM_024837.2	NP_079113.2	Q8TF62	AT8B4_HUMAN	ATPase, class I, type 8B, member 4	53					ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			breast(6)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(14)|lung(27)|ovary(2)|pancreas(1)|prostate(1)|skin(7)|urinary_tract(1)	73		all_lung(180;0.00183)		all cancers(107;2.41e-07)|GBM - Glioblastoma multiforme(94;8.28e-05)		TGCCACTCTTTGGAACTGTTC	0.299000													10	46					0	0	0.411799	0	0
OR2L2	26246	broad.mit.edu	37	1	248201902	248201902	+	Silent	SNP	G	G	T			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr1:248201902G>T	ENST00000366479.2	+	1	429	c.333G>T	c.(331-333)ggG>ggT	p.G111G	OR2L13_ENST00000366478.2_Intron	NM_001004686.2	NP_001004686.1	Q8NH16	OR2L2_HUMAN	olfactory receptor, family 2, subfamily L, member 2	111					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(28)|ovary(1)|skin(4)|urinary_tract(1)	42	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0278)			TTGCAGAAGGGCTGCTCCTGA	0.418000													50	180					2.52991e-16	3.43634e-16	0.870114	1	0
HS6ST3	266722	broad.mit.edu	37	13	97485168	97485168	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr13:97485168C>G	ENST00000376705.2	+	2	1156	c.1132C>G	c.(1132-1134)Cag>Gag	p.Q378E		NM_153456.3	NP_703157.2	Q8IZP7	H6ST3_HUMAN	heparan sulfate 6-O-sulfotransferase 3	378						integral to membrane	sulfotransferase activity			NS(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(10)|ovary(1)|pancreas(1)|skin(1)	20	all_neural(89;0.0878)|Medulloblastoma(90;0.163)					CCCCTTCACACAGTTCAACAT	0.498000													27	81					0	0	0.667858	0	0
MROH9	80133	broad.mit.edu	37	1	170928657	170928657	+	Silent	SNP	C	C	A			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr1:170928657C>A	ENST00000367759.4	+	5	361	c.207C>A	c.(205-207)tcC>tcA	p.S69S	MROH9_ENST00000367758.3_Silent_p.S69S	NM_001163629.1	NP_001157101.1			maestro heat-like repeat family member 9																		TAGAGTCATCCTTTGGAATGC	0.353000													8	70					1.12685e-05	1.23905e-05	0.307466	1	0
OR6F1	343169	broad.mit.edu	37	1	247875472	247875472	+	Nonsense_Mutation	SNP	C	C	A			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr1:247875472C>A	ENST00000302084.2	-	1	633	c.586G>T	c.(586-588)Gag>Tag	p.E196*	RP11-634B7.4_ENST00000449298.1_RNA	NM_001005286.1	NP_001005286.1	Q8NGZ6	OR6F1_HUMAN	olfactory receptor, family 6, subfamily F, member 1	196					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|kidney(1)|large_intestine(5)|lung(34)|skin(2)|stomach(2)|upper_aerodigestive_tract(2)	47	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.0168)			GCCACAAGCTCTACTGCCTGT	0.532000													59	95					3.89483e-19	5.43564e-19	0.870114	1	0
NYAP2	57624	broad.mit.edu	37	2	226516174	226516174	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr2:226516174C>T	ENST00000272907.6	+	6	2268	c.1855C>T	c.(1855-1857)Cgg>Tgg	p.R619W		NM_020864.1	NP_065915.1	Q9P242	K1486_HUMAN	neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2	619																	CAAATTAGGCCGGTCTGCGTC	0.493000													9	197					0	0	0.307466	0	0
FAM227B	196951	broad.mit.edu	37	15	49800505	49800505	+	Silent	SNP	C	C	G			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr15:49800505C>G	ENST00000299338.6	-	11	1218	c.915G>C	c.(913-915)ctG>ctC	p.L305L	FAM227B_ENST00000561064.1_Silent_p.L271L	NM_152647.2	NP_689860.2			family with sequence similarity 227, member B																		AGAGTTCTTTCAGTTTCCAGT	0.318000													26	69					0	0	0.706142	0	0
PDE10A	10846	broad.mit.edu	37	6	165808737	165808737	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr6:165808737C>A	ENST00000366882.1	-	16	1562	c.1408G>T	c.(1408-1410)Ggt>Tgt	p.G470C	PDE10A_ENST00000539869.2_Missense_Mutation_p.G480C|PDE10A_ENST00000354448.4_Missense_Mutation_p.G470C			Q9Y233	PDE10_HUMAN	phosphodiesterase 10A	470					platelet activation|signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cAMP binding|cGMP binding|metal ion binding	p.G470C(1)		breast(4)|endometrium(5)|kidney(1)|large_intestine(13)|liver(1)|lung(39)|ovary(3)|skin(4)|upper_aerodigestive_tract(1)	71		Breast(66;0.000425)|Prostate(117;0.104)|Ovarian(120;0.221)		OV - Ovarian serous cystadenocarcinoma(33;1.5e-17)|BRCA - Breast invasive adenocarcinoma(81;1.8e-06)|GBM - Glioblastoma multiforme(31;1.92e-05)	Dipyridamole(DB00975)	TCAAAAGGACCAATGTCAAAG	0.333000													8	22					0.00448238	0.00460941	0.307466	1	0
AMER2	219287	broad.mit.edu	37	13	25743844	25743844	+	Missense_Mutation	SNP	T	T	A			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr13:25743844T>A	ENST00000357816.2	-	3	2032	c.1557A>T	c.(1555-1557)aaA>aaT	p.K519N	AMER2_ENST00000381853.3_Missense_Mutation_p.K519N|AMER2_ENST00000515384.1_Missense_Mutation_p.K638N					APC membrane recruitment protein 2																		AAACCGGGATTTTTGTTCTGG	0.552000													28	97					0	0	0.693898	0	0
CYP4F24P	388514	broad.mit.edu	37	19	15882034	15882034	+	RNA	SNP	C	C	A			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr19:15882034C>A	ENST00000587443.2	-	0	863					NR_033864.1																						GCACTGAGCTCCAAGATGGTA	0.527000													15	34					1.15088e-07	1.37241e-07	0.500413	1	0
VGLL4	9686	broad.mit.edu	37	3	11600212	11600212	+	Missense_Mutation	SNP	C	C	G	rs147755206		TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr3:11600212C>G	ENST00000273038.3	-	6	1056	c.691G>C	c.(691-693)Gtg>Ctg	p.V231L	VGLL4_ENST00000430365.2_Missense_Mutation_p.V237L|VGLL4_ENST00000451674.2_Missense_Mutation_p.V151L|VGLL4_ENST00000404339.1_Missense_Mutation_p.V236L|VGLL4_ENST00000424529.2_Missense_Mutation_p.V147L|VGLL4_ENST00000413604.1_Missense_Mutation_p.V172L	NM_014667.2	NP_055482.2	Q14135	VGLL4_HUMAN	vestigial like 4 (Drosophila)	231					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				NS(1)|endometrium(1)|large_intestine(1)|ovary(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	10				LUSC - Lung squamous cell carcinoma(1;0.089)|Lung(1;0.111)		GTGATGGACACGGAGTTGGGT	0.627000													42	63					0	0	0.853193	0	0
SEC24D	9871	broad.mit.edu	37	4	119718857	119718857	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr4:119718857G>A	ENST00000379735.5	-	8	1296	c.1025C>T	c.(1024-1026)gCc>gTc	p.A342V	SEC24D_ENST00000419654.2_5'UTR|SEC24D_ENST00000280551.6_Missense_Mutation_p.A341V	NM_014822.2	NP_055637.2	O94855	SC24D_HUMAN	SEC24 family member D	341					COPII vesicle coating|intracellular protein transport|post-translational protein modification|protein N-linked glycosylation via asparagine	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|Golgi membrane|perinuclear region of cytoplasm	zinc ion binding			breast(3)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(10)|lung(13)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	37						AGGAATGGTGGCAAAGGGCTT	0.348000													27	67					0	0	0.717897	0	0
ATP8A2	51761	broad.mit.edu	37	13	26116088	26116088	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr13:26116088G>T	ENST00000381655.2	+	9	825	c.683G>T	c.(682-684)cGt>cTt	p.R228L	ATP8A2_ENST00000255283.8_Missense_Mutation_p.R188L	NM_016529.4	NP_057613.4	Q9NTI2	AT8A2_HUMAN	ATPase, aminophospholipid transporter, class I, type 8A, member 2	188					ATP biosynthetic process|negative regulation of cell proliferation	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			breast(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(17)|lung(31)|ovary(4)|skin(3)|stomach(1)|urinary_tract(1)	72		Breast(139;0.0201)|Lung SC(185;0.0225)		all cancers(112;0.043)|OV - Ovarian serous cystadenocarcinoma(117;0.0748)|Epithelial(112;0.079)		ATGCAAACACGTGAAGTTCTG	0.433000													20	68					0.00887093	0.00904906	0.575678	1	0
IL15	3600	broad.mit.edu	37	4	142640546	142640546	+	Translation_Start_Site	SNP	G	G	A			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr4:142640546G>A	ENST00000477265.1	+	0	4737				IL15_ENST00000514653.1_De_novo_Start_OutOfFrame|IL15_ENST00000529613.1_De_novo_Start_OutOfFrame|IL15_ENST00000296545.7_De_novo_Start_OutOfFrame|IL15_ENST00000320650.4_De_novo_Start_OutOfFrame			P40933	IL15_HUMAN	interleukin 15						cell-cell signaling|immune response|positive regulation of interleukin-17 production	endosome|extracellular space|Golgi apparatus|integral to plasma membrane|membrane fraction|nucleus	cytokine activity|cytokine receptor binding|signal transducer activity			kidney(1)|large_intestine(1)|lung(2)|stomach(1)	5	all_hematologic(180;0.158)					ATTGTGGATGGATGGCTGCTG	0.378000													9	18					0	0	0.307466	0	0
AURKC	6795	broad.mit.edu	37	19	57743553	57743553	+	Missense_Mutation	SNP	A	A	G			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr19:57743553A>G	ENST00000302804.7	+	3	443	c.257A>G	c.(256-258)cAc>cGc	p.H86R	AURKC_ENST00000448930.1_Missense_Mutation_p.H52R|AURKC_ENST00000599062.1_Missense_Mutation_p.H83R|AURKC_ENST00000598785.1_Missense_Mutation_p.H52R|AURKC_ENST00000415300.2_Missense_Mutation_p.H67R	NM_001015878.1	NP_001015878.1	Q9UQB9	AURKC_HUMAN	aurora kinase C	86	Protein kinase.				cell cycle|cytokinesis	condensed chromosome|cytoplasm|midbody|spindle midzone	ATP binding|protein serine/threonine kinase activity			breast(1)|endometrium(1)|large_intestine(9)|lung(9)|ovary(3)|prostate(1)|stomach(1)	25		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0122)		GGACTGGAGCACCAGCTGCGC	0.498000													12	45					0	0	0.457914	0	0
HJURP	55355	broad.mit.edu	37	2	234750291	234750291	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr2:234750291C>T	ENST00000411486.2	-	8	1200	c.1135G>A	c.(1135-1137)Gtg>Atg	p.V379M	HJURP_ENST00000441687.1_Missense_Mutation_p.V294M|HJURP_ENST00000432087.1_Missense_Mutation_p.V325M	NM_018410.3	NP_060880.3	Q8NCD3	HJURP_HUMAN	Holliday junction recognition protein	379					cell cycle|CenH3-containing nucleosome assembly at centromere|centromeric core chromatin assembly|chromosome segregation|regulation of DNA binding|regulation of protein complex assembly	condensed chromosome kinetochore|cytoplasm|nucleolus|nucleoplasm	DNA binding|histone binding			NS(2)|breast(2)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(3)|lung(11)|ovary(2)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	38		Breast(86;0.00204)|all_lung(227;0.00433)|Renal(207;0.00685)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0326)|Lung NSC(271;0.0719)|Lung SC(224;0.128)		Epithelial(121;2.01e-18)|BRCA - Breast invasive adenocarcinoma(100;0.000186)|Lung(119;0.00521)|LUSC - Lung squamous cell carcinoma(224;0.00829)		GAGGGTGTCACTTTGCGCTCC	0.368000													26	62					0	0	0.667858	0	0
KCNS2	3788	broad.mit.edu	37	8	99441351	99441351	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr8:99441351C>A	ENST00000287042.4	+	2	1494	c.1144C>A	c.(1144-1146)Cca>Aca	p.P382T	KCNS2_ENST00000521839.1_Missense_Mutation_p.P382T	NM_020697.2	NP_065748.1	Q9ULS6	KCNS2_HUMAN	potassium voltage-gated channel, delayed-rectifier, subfamily S, member 2	382						voltage-gated potassium channel complex	voltage-gated potassium channel activity			autonomic_ganglia(1)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(11)|ovary(1)|prostate(1)|skin(1)|urinary_tract(2)	31	Breast(36;2.4e-06)		OV - Ovarian serous cystadenocarcinoma(57;0.0448)			GGATGTGGTCCCAGGGACCAC	0.592000													21	115					3.51602e-12	4.55647e-12	0.575678	1	0
KIF4B	285643	broad.mit.edu	37	5	154394386	154394386	+	Missense_Mutation	SNP	A	A	G			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr5:154394386A>G	ENST00000435029.4	+	1	1127	c.967A>G	c.(967-969)Aca>Gca	p.T323A		NM_001099293.1	NP_001092763.1	Q2VIQ3	KIF4B_HUMAN	kinesin family member 4B	323	Kinesin-motor.				axon guidance|blood coagulation|microtubule-based movement	cytosol|microtubule|nuclear matrix	ATP binding|DNA binding|microtubule motor activity			breast(1)|central_nervous_system(1)|endometrium(7)|kidney(6)|large_intestine(13)|lung(27)|ovary(2)|upper_aerodigestive_tract(1)	58	Renal(175;0.00488)	Medulloblastoma(196;0.0523)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)			TCTAGAGGAAACATTAAGTAC	0.413000													42	209					0	0	0.853193	0	0
OGFR	11054	broad.mit.edu	37	20	61444194	61444194	+	Silent	SNP	G	G	A			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr20:61444194G>A	ENST00000370461.1	+	5	3348	c.1071G>A	c.(1069-1071)aaG>aaA	p.K357K	OGFR_ENST00000370468.3_Silent_p.K409K|OGFR_ENST00000290291.6_Silent_p.K409K			Q9NZT2	OGFR_HUMAN	opioid growth factor receptor	409					regulation of cell growth	cytoplasm|membrane|nucleus	opioid receptor activity			endometrium(2)|kidney(1)|lung(4)|prostate(3)|skin(4)|upper_aerodigestive_tract(3)	17	Breast(26;3.65e-08)					AGGTGGAGAAGATCGCTCTGA	0.652000													11	40					0	0	0.387290	0	0
PCDHGA11	56105	broad.mit.edu	37	5	140802012	140802012	+	Silent	SNP	A	A	T			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr5:140802012A>T	ENST00000398587.2	+	1	1251	c.1218A>T	c.(1216-1218)atA>atT	p.I406I	PCDHGA3_ENST00000253812.6_Intron|PCDHGA6_ENST00000517434.1_Intron|PCDHGB3_ENST00000576222.1_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGB4_ENST00000519479.1_Intron|PCDHGA7_ENST00000518325.1_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGA9_ENST00000573521.1_Intron|PCDHGA11_ENST00000518882.1_Silent_p.I406I|PCDHGB7_ENST00000398594.2_Intron|PCDHGA8_ENST00000398604.2_Intron|PCDHGB6_ENST00000520790.1_Intron|PCDHGA10_ENST00000398610.2_Intron	NM_018914.2|NM_032092.1	NP_061737.1|NP_114481.1														breast(3)|endometrium(8)|kidney(3)|large_intestine(9)|lung(22)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(1)	49			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ACAAATTGATAACAAGCAGAG	0.413000													11	67					0	0	0.361761	0	0
DCAF10	79269	broad.mit.edu	37	9	37857288	37857288	+	Missense_Mutation	SNP	T	T	A			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr9:37857288T>A	ENST00000377724.3	+	5	1470	c.1105T>A	c.(1105-1107)Tgt>Agt	p.C369S	DCAF10_ENST00000242323.7_Intron|RP11-613M10.9_ENST00000540557.1_Intron|DCAF10_ENST00000483167.1_Intron	NM_024345.3	NP_077321.3	Q5QP82	DCA10_HUMAN	DDB1 and CUL4 associated factor 10	369	Ser-rich.					CUL4 RING ubiquitin ligase complex				central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(4)|skin(1)	12						TGGCTCACCTTGTCATCATAG	0.348000													36	146					0	0	0.840704	0	0
LRP1	4035	broad.mit.edu	37	12	57573898	57573898	+	Missense_Mutation	SNP	T	T	G			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr12:57573898T>G	ENST00000243077.3	+	31	5676	c.5210T>G	c.(5209-5211)cTc>cGc	p.L1737R		NM_002332.2	NP_002323.2	Q07954	LRP1_HUMAN	low density lipoprotein receptor-related protein 1	1737					aorta morphogenesis|apoptotic cell clearance|negative regulation of platelet-derived growth factor receptor-beta signaling pathway|negative regulation of smooth muscle cell migration|negative regulation of Wnt receptor signaling pathway|positive regulation of cholesterol efflux|regulation of actin cytoskeleton organization|regulation of phospholipase A2 activity	coated pit|integral to plasma membrane|nucleus	apolipoprotein E binding|calcium ion binding|lipoprotein transporter activity|protein complex binding|receptor activity			NS(1)|breast(9)|central_nervous_system(3)|cervix(3)|endometrium(33)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(26)|lung(58)|ovary(10)|pancreas(2)|prostate(11)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(5)	184				BRCA - Breast invasive adenocarcinoma(357;0.0103)	Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Becaplermin(DB00102)|Coagulation Factor IX(DB00100)|Tenecteplase(DB00031)	CGCACCCTGCTCTTCAGTGGC	0.612000													54	145					0	0	0.870114	0	0
RNF139	11236	broad.mit.edu	37	8	125487455	125487455	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr8:125487455C>A	ENST00000303545.3	+	1	477	c.105C>A	c.(103-105)gaC>gaA	p.D35E		NM_007218.3	NP_009149.2	Q8WU17	RN139_HUMAN	ring finger protein 139	35					negative regulation of cell proliferation|regulation of protein ubiquitination	endoplasmic reticulum membrane|integral to membrane	protein binding|receptor activity|ubiquitin-protein ligase activity|zinc ion binding			breast(1)|endometrium(3)|kidney(3)|large_intestine(6)|liver(1)|lung(4)|prostate(1)|skin(1)	20	Ovarian(258;0.00438)|all_neural(195;0.0779)|Hepatocellular(40;0.108)		STAD - Stomach adenocarcinoma(47;0.00288)			ACATCATCGACGCCATCTTCA	0.637000													9	105					1.58986e-06	1.81903e-06	0.361761	1	0
KLHL12	59349	broad.mit.edu	37	1	202863732	202863732	+	Silent	SNP	C	C	T			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr1:202863732C>T	ENST00000367261.3	-	9	1499	c.1281G>A	c.(1279-1281)gtG>gtA	p.V427V	KLHL12_ENST00000435533.3_Silent_p.V465V|KLHL12_ENST00000367259.1_Silent_p.V160V	NM_021633.2	NP_067646.1	Q53G59	KLH12_HUMAN	kelch-like family member 12	427	Interaction with DVL3.				Wnt receptor signaling pathway		protein binding			NS(3)|breast(2)|endometrium(1)|large_intestine(1)|lung(6)|stomach(1)	14			BRCA - Breast invasive adenocarcinoma(75;0.166)			GACAGTAGATCACTCCACTGG	0.512000													53	157					0	0	0.870114	0	0
MAP1B	4131	broad.mit.edu	37	5	71493280	71493280	+	Silent	SNP	T	T	C			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr5:71493280T>C	ENST00000296755.7	+	5	4396	c.4098T>C	c.(4096-4098)agT>agC	p.S1366S		NM_005909.3	NP_005900.2	P46821	MAP1B_HUMAN	microtubule-associated protein 1B	1366						microtubule|microtubule associated complex	structural molecule activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(42)|liver(1)|lung(28)|ovary(1)|pancreas(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	104		Lung NSC(167;0.00202)|Ovarian(174;0.0175)|Prostate(461;0.142)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;7.99e-54)		TTGAATTCAGTGATGCCAAAG	0.443000													21	61					0	0	0.681144	0	0
RXRG	6258	broad.mit.edu	37	1	165386317	165386317	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr1:165386317G>A	ENST00000359842.5	-	4	885	c.583C>T	c.(583-585)Cgc>Tgc	p.R195C	RXRG_ENST00000470566.1_5'UTR	NM_001256570.1|NM_006917.4	NP_001243499.1|NP_008848.1	P48443	RXRG_HUMAN	retinoid X receptor, gamma	195					regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	retinoid-X receptor activity|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|zinc ion binding			endometrium(1)|kidney(3)|large_intestine(6)|lung(22)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	38	all_hematologic(923;0.0773)|Acute lymphoblastic leukemia(8;0.155)				Acitretin(DB00459)|Adapalene(DB00210)|Alitretinoin(DB00523)|Etretinate(DB00926)|Tretinoin(DB00755)	TTCTGATAGCGACAGTACTGG	0.512000													18	63					0	0	0.520397	0	0
CBX3	11335	broad.mit.edu	37	7	26242643	26242643	+	Splice_Site	SNP	G	G	A			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr7:26242643G>A	ENST00000337620.4	+	2	452		c.e2+1		CBX3_ENST00000497498.1_Splice_Site|CBX3_ENST00000409747.1_Splice_Site|CBX3_ENST00000396386.2_Splice_Site	NM_007276.4	NP_009207.2	Q13185	CBX3_HUMAN	chromobox homolog 3						chromatin remodeling|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	condensed chromosome, centromeric region|nuclear centromeric heterochromatin|nuclear euchromatin|nuclear inner membrane|spindle	enzyme binding|protein domain specific binding			endometrium(4)|large_intestine(2)|lung(2)|ovary(1)	9						AACTACATTGGTAAGTTAATG	0.328000													7	74					0	0	0.248553	0	0
SI	6476	broad.mit.edu	37	3	164766975	164766975	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr3:164766975C>G	ENST00000264382.3	-	15	1717	c.1655G>C	c.(1654-1656)tGg>tCg	p.W552S		NM_001041.3	NP_001032.2	P14410	SUIS_HUMAN	sucrase-isomaltase (alpha-glucosidase)	552	Isomaltase.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			NS(4)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(6)|kidney(10)|large_intestine(18)|lung(124)|ovary(9)|pancreas(1)|prostate(6)|skin(6)|upper_aerodigestive_tract(16)|urinary_tract(1)	218		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	CTGTTTACCCCAGTTCTGCAC	0.333000										HNSCC(35;0.089)			14	55					0	0	0.479597	0	0
KRTAP10-8	386681	broad.mit.edu	37	21	46032335	46032335	+	Silent	SNP	G	G	A	rs143349829	byFrequency	TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr21:46032335G>A	ENST00000334662.2	+	1	340	c.318G>A	c.(316-318)ccG>ccA	p.P106P	TSPEAR_ENST00000323084.4_Intron	NM_198695.2	NP_941968.2	P60410	KR108_HUMAN	keratin associated protein 10-8	106	19 X 5 AA repeats of C-C-X(3).					keratin filament				breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(8)|skin(1)	17						GCTGCCAGCCGGCTTGCTGCA	0.642000													9	268					0	0	0.435327	0	0
OR2F2	135948	broad.mit.edu	37	7	143633211	143633211	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr7:143633211G>C	ENST00000408955.2	+	1	953	c.886G>C	c.(886-888)Gag>Cag	p.E296Q		NM_001004685.1	NP_001004685.1	O95006	OR2F2_HUMAN	olfactory receptor, family 2, subfamily F, member 2	296					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(19)|ovary(3)|skin(2)|stomach(1)|urinary_tract(1)	32	Melanoma(164;0.0903)					AAGGAATAAAGAGGTGAAGGG	0.433000													16	56					0	0	0.539581	0	0
ATP8B4	79895	broad.mit.edu	37	15	50168535	50168535	+	Silent	SNP	A	A	T			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr15:50168535A>T	ENST00000284509.6	-	25	3108	c.2967T>A	c.(2965-2967)gcT>gcA	p.A989A	ATP8B4_ENST00000559829.1_Silent_p.A989A	NM_024837.2	NP_079113.2	Q8TF62	AT8B4_HUMAN	ATPase, class I, type 8B, member 4	989					ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			breast(6)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(14)|lung(27)|ovary(2)|pancreas(1)|prostate(1)|skin(7)|urinary_tract(1)	73		all_lung(180;0.00183)		all cancers(107;2.41e-07)|GBM - Glioblastoma multiforme(94;8.28e-05)		ACTGGTAGTCAGCAATATGTT	0.468000													12	54					0	0	0.387290	0	0
CYB5R4	51167	broad.mit.edu	37	6	84630848	84630848	+	Silent	SNP	T	T	C			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr6:84630848T>C	ENST00000369681.4	+	8	752	c.612T>C	c.(610-612)ttT>ttC	p.F204F		NM_016230.3	NP_057314.2	Q7L1T6	NB5R4_HUMAN	cytochrome b5 reductase 4	204	CS.				cell development|detection of oxygen|generation of precursor metabolites and energy|glucose homeostasis|insulin secretion|response to antibiotic|superoxide metabolic process	endoplasmic reticulum|perinuclear region of cytoplasm	cytochrome-b5 reductase activity|heme binding|NAD(P)H oxidase activity			breast(3)|endometrium(2)|kidney(2)|large_intestine(7)|lung(7)|prostate(1)|upper_aerodigestive_tract(1)	23		all_cancers(76;7e-07)|Acute lymphoblastic leukemia(125;2.69e-07)|all_hematologic(105;0.000151)|all_epithelial(107;0.00128)		BRCA - Breast invasive adenocarcinoma(397;0.0871)		ATGATTCCTTTAGAGCAGAAA	0.274000													11	12					0	0	0.387290	0	0
TRAV27	28655	broad.mit.edu	37	14	22616452	22616452	+	RNA	SNP	G	G	T			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr14:22616452G>T	ENST00000390457.2	+	0	290																											TGTCCTCCTGGTGACAGTAGT	0.488000													14	44					9.31168e-06	1.03282e-05	0.435327	1	0
PCDHGB6	56100	broad.mit.edu	37	5	140788211	140788211	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr5:140788211G>T	ENST00000520790.1	+	1	442	c.442G>T	c.(442-444)Gct>Tct	p.A148S	PCDHGA3_ENST00000253812.6_Intron|PCDHGA6_ENST00000517434.1_Intron|PCDHGB3_ENST00000576222.1_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGB4_ENST00000519479.1_Intron|PCDHGA7_ENST00000518325.1_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGA9_ENST00000573521.1_Intron|PCDHGA8_ENST00000398604.2_Intron	NM_018926.2|NM_032100.1	NP_061749.1|NP_115271.1														breast(2)|central_nervous_system(2)|endometrium(9)|kidney(1)|large_intestine(10)|lung(16)|ovary(1)|prostate(3)|stomach(2)|upper_aerodigestive_tract(2)	48			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ATCTGCATCCGCTGGTACACG	0.333000													11	44					9.05144e-12	1.16704e-11	0.435327	1	0
OR2W3	343171	broad.mit.edu	37	1	248059229	248059229	+	Missense_Mutation	SNP	T	T	A			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr1:248059229T>A	ENST00000537741.1	+	3	598	c.341T>A	c.(340-342)cTt>cAt	p.L114H	OR2W3_ENST00000360358.3_Missense_Mutation_p.L114H			Q7Z3T1	OR2W3_HUMAN	olfactory receptor, family 2, subfamily W, member 3	114					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|kidney(2)|large_intestine(2)|lung(33)|ovary(1)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(3)	49	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0319)			GAGTGCCTGCTTCTGGCTGTC	0.567000													29	69					0	0	0.729181	0	0
UTP20	27340	broad.mit.edu	37	12	101732712	101732712	+	Silent	SNP	T	T	C			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr12:101732712T>C	ENST00000261637.4	+	31	4164	c.3990T>C	c.(3988-3990)agT>agC	p.S1330S		NM_014503.2	NP_055318.2	O75691	UTP20_HUMAN	UTP20, small subunit (SSU) processome component, homolog (yeast)	1330					endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|negative regulation of cell proliferation	90S preribosome|cytoplasm|nucleolus|nucleoplasm|preribosome, small subunit precursor|small-subunit processome	protein binding			NS(3)|biliary_tract(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(26)|lung(30)|ovary(2)|prostate(3)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	88						CACAAGTCAGTAAAGAGCTTG	0.323000													16	39					0	0	0.479597	0	0
LRPPRC	10128	broad.mit.edu	37	2	44201338	44201338	+	Frame_Shift_Del	DEL	G	G	-			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr2:44201338delG	ENST00000260665.7	-	9	1163	c.1106delC	c.(1105-1107)cafs	p.P369fs	LRPPRC_ENST00000409659.1_Frame_Shift_Del_p.P369fs|LRPPRC_ENST00000409946.1_Frame_Shift_Del_p.P369fs	NM_133259.3	NP_573566.2	P42704	LPPRC_HUMAN	leucine-rich pentatricopeptide repeat containing	369					mitochondrion transport along microtubule|mRNA transport|regulation of transcription, DNA-dependent|transcription, DNA-dependent	condensed nuclear chromosome|cytoskeleton|mitochondrial nucleoid|nuclear inner membrane|nuclear outer membrane|nucleoplasm|perinuclear region of cytoplasm	beta-tubulin binding|microtubule binding|RNA binding			breast(3)|endometrium(3)|kidney(5)|large_intestine(9)|lung(15)|ovary(2)|prostate(2)|skin(2)	41		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)				AAAGACACTTGGGCCATCTTC	0.378													20	79	---	---	---	---					
MTIF2	4528	broad.mit.edu	37	2	55464460	55464461	+	Frame_Shift_Ins	INS	-	-	T			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr2:55464460_55464461insT	ENST00000394600.3	-	16	2710_2711	c.1974_1975insA	c.(1972-1977)aattaafs	p.N*658fs	MTIF2_ENST00000263629.4_Frame_Shift_Ins_p.N*658fs|MTIF2_ENST00000403721.1_Frame_Shift_Ins_p.N*658fs	NM_001005369.1	NP_001005369.1	P46199	IF2M_HUMAN	mitochondrial translational initiation factor 2	658					regulation of translational initiation	mitochondrion	GTP binding|GTPase activity|ribosomal small subunit binding|translation initiation factor activity			breast(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(5)|ovary(1)|prostate(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)	24						GTTAGTTTAAATTTTTTTTGTT	0.381													23	79	---	---	---	---					
LOC646762	646762	broad.mit.edu	37	7	29720482	29720483	+	RNA	INS	-	-	G	rs70980562		TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr7:29720482_29720483insG	ENST00000426767.1	-	0	366					NR_024278.1																						CTCTCAGATCAGTGATGCCCTG	0.485													7	21	---	---	---	---					
TRGV3	6976	broad.mit.edu	37	7	38398480	38398481	+	RNA	INS	-	-	AA	rs3056123		TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr7:38398480_38398481insAA	ENST00000390346.2	-	0	226																											GCACCCCTTTCAAGAAGAAAAC	0.480													11	35	---	---	---	---					
KMT2C	58508	broad.mit.edu	37	7	151874148	151874148	+	Frame_Shift_Del	DEL	T	T	-			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr7:151874148delT	ENST00000355193.2	-	38	8608	c.8390delA	c.(8389-8391)agfs	p.K2797fs	KMT2C_ENST00000262189.6_Frame_Shift_Del_p.K2797fs					lysine (K)-specific methyltransferase 2C									p.K2797fs*26(20)									TTCTTGTTCCTTTTTTTTTGG	0.348													8	116	---	---	---	---					
GOT1L1	137362	broad.mit.edu	37	8	37791834	37791834	+	Frame_Shift_Del	DEL	T	T	-			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr8:37791834delT	ENST00000307599.4	-	9	1342	c.1243delA	c.(1243-1245)cafs	p.T415fs		NM_152413.2	NP_689626.2	Q8NHS2	AATC2_HUMAN	glutamic-oxaloacetic transaminase 1-like 1	415					biosynthetic process|cellular amino acid metabolic process	cytoplasm	pyridoxal phosphate binding|transaminase activity			central_nervous_system(1)|endometrium(3)|lung(8)|ovary(1)|prostate(1)	14	Colorectal(12;0.00627)	Lung NSC(58;0.118)|all_lung(54;0.195)	LUSC - Lung squamous cell carcinoma(8;1.37e-11)			CCAATCAGTGTTTTTTTTTCC	0.373													8	68	---	---	---	---					
OR10A2	341276	broad.mit.edu	37	11	6891666	6891666	+	Frame_Shift_Del	DEL	A	A	-			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr11:6891666delA	ENST00000307322.4	+	1	743	c.681delA	c.(679-681)acfs	p.T227fs		NM_001004460.1	NP_001004460.1	Q9H208	O10A2_HUMAN	olfactory receptor, family 10, subfamily A, member 2	227					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(3)|large_intestine(4)|lung(12)|urinary_tract(1)	24		Medulloblastoma(188;0.0523)|all_neural(188;0.236)		Epithelial(150;4.89e-08)|BRCA - Breast invasive adenocarcinoma(625;0.13)		CCTTTTCTACATGTTCCTCAC	0.438													50	171	---	---	---	---					
OR5T1	390155	broad.mit.edu	37	11	56044054	56044054	+	Frame_Shift_Del	DEL	A	A	-			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr11:56044054delA	ENST00000313033.2	+	1	1026	c.940delA	c.(940-942)aafs	p.K314fs		NM_001004745.1	NP_001004745.1	Q8NG75	OR5T1_HUMAN	olfactory receptor, family 5, subfamily T, member 1	314					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|endometrium(5)|kidney(1)|large_intestine(2)|lung(27)|ovary(2)|pancreas(1)|prostate(2)|skin(1)	43	Esophageal squamous(21;0.00448)					GGAGGCAATCAAAAGATTGCT	0.343													32	88	---	---	---	---					
KRT1	3848	broad.mit.edu	37	12	53069236	53069256	+	In_Frame_Del	DEL	TAGCTGCTACCTCCGGAGCCA	TAGCTGCTACCTCCGGAGCCA	-	rs66529359	by1000genomes	TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr12:53069236_53069256delTAGCTGCTACCTCCGGAGCCA	ENST00000252244.3	-	9	1714_1734	c.1656_1676delTGGCTCCGGAGGTAGCAGCTA	c.(1654-1677)tac>ta	p.YGSGGSSY552del		NM_006121.3	NP_006112.3	P04264	K2C1_HUMAN	keratin 1	552	Gly/Ser-rich.|Tail.				complement activation, lectin pathway|epidermis development|fibrinolysis|regulation of angiogenesis|response to oxidative stress	plasma membrane	protein binding|receptor activity|structural constituent of cytoskeleton|sugar binding	p.S557_G563delSSYGSGG(3)		breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(7)|lung(11)|ovary(1)|prostate(7)|skin(3)	39						tccggagccgtagctgctacctccggagccatagctgccac	0.688													3	5	---	---	---	---					
ABCC11	85320	broad.mit.edu	37	16	48245000	48245000	+	Frame_Shift_Del	DEL	C	C	-			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr16:48245000delC	ENST00000394747.1	-	10	1816	c.1467delG	c.(1465-1467)ggfs	p.G489fs	ABCC11_ENST00000353782.5_Frame_Shift_Del_p.G489fs|ABCC11_ENST00000537808.1_Frame_Shift_Del_p.G489fs|ABCC11_ENST00000356608.2_Frame_Shift_Del_p.G489fs|ABCC11_ENST00000394748.1_Frame_Shift_Del_p.G489fs	NM_033151.3	NP_149163.2	Q96J66	ABCCB_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 11	489						integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(3)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(42)|ovary(3)|prostate(2)|skin(5)|urinary_tract(2)	83		all_cancers(37;0.127)|all_lung(18;0.132)|Breast(268;0.166)				CATTGACGATCCCGGGACAGG	0.577													29	117	---	---	---	---					
TP53	7157	broad.mit.edu	37	17	7577058	7577058	+	Frame_Shift_Del	DEL	C	C	-			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr17:7577058delC	ENST00000420246.2	-	8	1012	c.880delG	c.(880-882)agfs	p.E294fs	TP53_ENST00000413465.2_Intron|TP53_ENST00000455263.2_Frame_Shift_Del_p.E294fs|TP53_ENST00000359597.4_Frame_Shift_Del_p.E294fs|TP53_ENST00000269305.4_Frame_Shift_Del_p.E294fs|TP53_ENST00000445888.2_Frame_Shift_Del_p.E294fs	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	294	Interaction with E4F1.|Interaction with HIPK1 (By similarity).		E -> A (in a sporadic cancer; somatic mutation).|E -> D (in sporadic cancers; somatic mutation).|E -> G (in sporadic cancers; somatic mutation).|E -> K (in sporadic cancers; somatic mutation).|E -> Q (in sporadic cancers; somatic mutation).|E -> V (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.E294*(46)|p.E294fs*51(9)|p.K291fs*48(8)|p.0?(8)|p.E294K(3)|p.E294fs*12(3)|p.?(2)|p.E294Q(2)|p.L265_K305del41(1)|p.E294>*(1)|p.G293fs*1(1)|p.R290fs*50(1)|p.R290_P295>X(1)|p.E294fs*11(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		TGGTGAGGCTCCCCTTTCTTG	0.567		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			18	56	---	---	---	---					
KCNG2	26251	broad.mit.edu	37	18	77623691	77623692	+	In_Frame_Ins	INS	-	-	GGC	rs71338073		TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr18:77623691_77623692insGGC	ENST00000316249.3	+	1	24_25	c.24_25insGGC	c.(22-27)ccgcgg>ccGGCgcgg	p.8_9PR>PAR		NM_012283.1	NP_036415.1	Q9UJ96	KCNG2_HUMAN	potassium voltage-gated channel, subfamily G, member 2	8					energy reserve metabolic process|regulation of heart contraction|regulation of insulin secretion	voltage-gated potassium channel complex	delayed rectifier potassium channel activity	p.P8_G9insG(2)		breast(2)|endometrium(4)|lung(7)|skin(1)|upper_aerodigestive_tract(4)	18		Esophageal squamous(42;0.0157)|Melanoma(33;0.144)		OV - Ovarian serous cystadenocarcinoma(15;6.92e-07)|BRCA - Breast invasive adenocarcinoma(31;0.0244)		CCTGCTccccgggcggcggcgg	0.772													3	4	---	---	---	---					
FRG1B	284802	broad.mit.edu	37	20	29625899	29625900	+	Frame_Shift_Ins	INS	-	-	AT			TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr20:29625899_29625900insAT	ENST00000278882.3	+	5	523_524	c.143_144insAT	c.(142-144)atafs	p.I48fs	FRG1B_ENST00000439954.2_Frame_Shift_Ins_p.I53fs|FRG1B_ENST00000358464.4_Frame_Shift_Ins_p.I48fs																endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						GGCTATGGAAAATATCTTGGTA	0.342													8	152	---	---	---	---					
KRTAP10-6	386674	broad.mit.edu	37	21	46012219	46012220	+	In_Frame_Ins	INS	-	-	GGGGCGCAGCAGCTG	rs71199613		TCGA-55-7914-01A-11D-2167-08	TCGA-55-7914-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	59bffff6-361e-4517-b620-42bb23398b5c	7fc655ab-9a59-4b5b-9b79-a38e3138445d	g.chr21:46012219_46012220insGGGGCGCAGCAGCTG	ENST00000400368.1	-	1	166_167	c.146_147insCAGCTGCTGCGCCCC	c.(145-147)cgc>cCAGCTGCTGCGCCCCgc	p.48_49insPAAAP	TSPEAR_ENST00000323084.4_Intron	NM_198688.2	NP_941961.2	P60371	KR106_HUMAN	keratin associated protein 10-6	48	29 X 5 AA repeats of C-C-X(3).					keratin filament				endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(6)|prostate(3)|skin(1)|stomach(1)|urinary_tract(1)	23						GGCAGGGGGCCGGGGCGCAGCA	0.688													10	77	---	---	---	---