Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
OR13F1	138805	broad.mit.edu	37	9	107267390	107267390	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr9:107267390C>A	ENST00000334726.2	+	1	936	c.847C>A	c.(847-849)Ccc>Acc	p.P283T		NM_001004485.1	NP_001004485.1	Q8NGS4	O13F1_HUMAN	olfactory receptor, family 13, subfamily F, member 1	283					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|large_intestine(6)|lung(17)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	31						CGGACAAACCCCCATGTTGAA	0.418000													24	49					9.57634e-11	1.25374e-10	1	1	0
COL18A1	80781	broad.mit.edu	37	21	46896293	46896293	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr21:46896293C>T	ENST00000359759.4	+	5	2093	c.2072C>T	c.(2071-2073)gCg>gTg	p.A691V	COL18A1_ENST00000355480.5_Missense_Mutation_p.A456V|COL18A1_ENST00000400337.2_Missense_Mutation_p.A276V			P39060	COIA1_HUMAN	collagen, type XVIII, alpha 1	691	Nonhelical region 1 (NC1).				cell adhesion|negative regulation of cell proliferation|organ morphogenesis|visual perception	collagen|extracellular space	extracellular matrix structural constituent|metal ion binding|protein binding			breast(1)|central_nervous_system(2)|endometrium(4)|kidney(2)|large_intestine(4)|lung(8)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	25				Colorectal(79;0.0157)|READ - Rectum adenocarcinoma(84;0.0929)		AGGCTCCCCGCGCCACCCCCC	0.637000													9	27					0	0	1	0	0
BTNL2	56244	broad.mit.edu	37	6	32374895	32374895	+	Silent	SNP	C	C	T			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr6:32374895C>T	ENST00000454136.3	-	1	10	c.6G>A	c.(4-6)gtG>gtA	p.V2V	BTNL2_ENST00000374993.1_Silent_p.V2V|BTNL2_ENST00000544175.1_5'UTR|BTNL2_ENST00000374995.3_Silent_p.V2V|BTNL2_ENST00000540315.1_Silent_p.V2V|BTNL2_ENST00000429232.2_Silent_p.V2V|BTNL2_ENST00000414363.1_Silent_p.V2V			Q9UIR0	BTNL2_HUMAN	butyrophilin-like 2 (MHC class II associated)	2						integral to membrane				central_nervous_system(3)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(5)|prostate(1)|urinary_tract(1)	19						CTGGAAAATCCACCATCCTCC	0.507000													27	58					0	0	1	0	0
SPTA1	6708	broad.mit.edu	37	1	158619707	158619707	+	Missense_Mutation	SNP	T	T	A			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr1:158619707T>A	ENST00000368148.3	-	25	3688	c.3508A>T	c.(3508-3510)Agg>Tgg	p.R1170W	SPTA1_ENST00000368147.3_Missense_Mutation_p.R1170W	NM_003126.2	NP_003117.2	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1 (elliptocytosis 2)	1170					actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			NS(3)|breast(7)|cervix(1)|endometrium(22)|kidney(9)|large_intestine(29)|liver(2)|lung(183)|ovary(5)|prostate(18)|skin(11)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(6)	307	all_hematologic(112;0.0378)					TCTGCAAGCCTCTGCAAAGAA	0.458000													11	36					0	0	1	0	0
KLHDC8A	55220	broad.mit.edu	37	1	205308439	205308439	+	Missense_Mutation	SNP	A	A	C			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr1:205308439A>C	ENST00000367156.3	-	7	1456	c.640T>G	c.(640-642)Ttc>Gtc	p.F214V	KLHDC8A_ENST00000539253.1_Missense_Mutation_p.F214V|KLHDC8A_ENST00000460687.1_Missense_Mutation_p.F80V|KLHDC8A_ENST00000367155.3_Missense_Mutation_p.F214V|KLHDC8A_ENST00000537168.1_Missense_Mutation_p.F101V	NM_001271863.1	NP_001258792.1	Q8IYD2	KLD8A_HUMAN	kelch domain containing 8A	214										breast(1)|endometrium(3)|large_intestine(1)|lung(4)|ovary(1)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	14	Breast(84;0.23)		BRCA - Breast invasive adenocarcinoma(75;0.117)			AAGCTGGAGAAGGCCCGCTTA	0.582000													11	41					0	0	1	0	0
ZNF431	170959	broad.mit.edu	37	19	21365588	21365588	+	Missense_Mutation	SNP	A	A	G			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr19:21365588A>G	ENST00000311048.7	+	5	626	c.482A>G	c.(481-483)tAt>tGt	p.Y161C	ZNF431_ENST00000594425.1_Intron|ZNF431_ENST00000600692.1_3'UTR	NM_133473.2	NP_597730.2	Q8TF32	ZN431_HUMAN	zinc finger protein 431	161					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(2)|endometrium(4)|large_intestine(7)|lung(7)|skin(1)|upper_aerodigestive_tract(1)	23						AAAGAAGGTTATAATGAGCTA	0.328000													14	47					0	0	1	0	0
PTPRN	5798	broad.mit.edu	37	2	220164773	220164773	+	Missense_Mutation	SNP	G	G	C			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr2:220164773G>C	ENST00000295718.2	-	9	1610	c.1370C>G	c.(1369-1371)aCg>aGg	p.T457R	AC114803.3_ENST00000417355.1_RNA|PTPRN_ENST00000423636.2_Missense_Mutation_p.T367R|PTPRN_ENST00000409251.3_Missense_Mutation_p.T457R	NM_002846.3	NP_002837.1	Q16849	PTPRN_HUMAN	protein tyrosine phosphatase, receptor type, N	457					response to reactive oxygen species	integral to plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			breast(3)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(28)|ovary(3)|prostate(4)|skin(11)|upper_aerodigestive_tract(1)|urinary_tract(1)	65		Renal(207;0.0474)		Epithelial(149;4.22e-07)|all cancers(144;8.82e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)|STAD - Stomach adenocarcinoma(1183;0.0875)		TCCTGCCACCGTGGGCTGGCT	0.602000													21	68					0	0	1	0	0
DAK	26007	broad.mit.edu	37	11	61109956	61109956	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr11:61109956C>T	ENST00000394900.3	+	8	908	c.679C>T	c.(679-681)Cgc>Tgc	p.R227C		NM_015533.3	NP_056348.2	Q3LXA3	DHAK_HUMAN	dihydroxyacetone kinase 2 homolog (S. cerevisiae)	227	DhaK.				glycerol metabolic process	cytosol	ATP binding|FAD-AMP lyase (cyclizing) activity|glycerone kinase activity|metal ion binding			NS(1)|breast(3)|endometrium(3)|large_intestine(5)|lung(8)|prostate(2)|upper_aerodigestive_tract(1)	23						AGCTGGTGTGCGCCGGATAAA	0.592000													19	88					0	0	1	0	0
ZNF471	57573	broad.mit.edu	37	19	57037191	57037191	+	Silent	SNP	C	C	T			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr19:57037191C>T	ENST00000308031.5	+	5	1888	c.1755C>T	c.(1753-1755)tcC>tcT	p.S585S	ZNF471_ENST00000593197.1_3'UTR|ZNF471_ENST00000591537.1_3'UTR	NM_020813.2	NP_065864.2	Q9BX82	ZN471_HUMAN	zinc finger protein 471	585					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|liver(2)|lung(8)|ovary(1)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	36		Colorectal(82;5.46e-05)|Ovarian(87;0.0822)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0307)		ATAGCTCATCCTGTGCTCAGC	0.403000													4	83					0	0	1	0	0
CRB1	23418	broad.mit.edu	37	1	197397003	197397003	+	Missense_Mutation	SNP	G	G	A	rs62636270		TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr1:197397003G>A	ENST00000367397.1	+	3	1549	c.691G>A	c.(691-693)Ggc>Agc	p.G231S	CRB1_ENST00000544212.1_Missense_Mutation_p.G331S|CRB1_ENST00000538660.1_Intron|CRB1_ENST00000367399.2_Missense_Mutation_p.G738S|CRB1_ENST00000367400.3_Missense_Mutation_p.G850S|CRB1_ENST00000535699.1_Missense_Mutation_p.G781S			P82279	CRUM1_HUMAN	crumbs homolog 1 (Drosophila)	850	EGF-like 6; calcium-binding (Potential).				cell-cell signaling|establishment or maintenance of cell polarity	apical plasma membrane|extracellular region|integral to membrane	calcium ion binding|protein binding			NS(1)|breast(4)|central_nervous_system(2)|cervix(3)|endometrium(13)|kidney(4)|large_intestine(21)|lung(58)|ovary(7)|prostate(3)|skin(10)|upper_aerodigestive_tract(4)|urinary_tract(2)	132						ATTCTTCAAAGGCTGTATCCA	0.393000													17	65					0	0	1	0	0
RBM10	8241	broad.mit.edu	37	X	47044523	47044523	+	Nonsense_Mutation	SNP	C	C	T			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chrX:47044523C>T	ENST00000377604.3	+	18	2762	c.2020C>T	c.(2020-2022)Cag>Tag	p.Q674*	RBM10_ENST00000345781.6_Nonsense_Mutation_p.Q597*|RBM10_ENST00000329236.7_Nonsense_Mutation_p.Q596*|RBM10_ENST00000468791.1_Intron	NM_001204467.1|NM_001204468.1|NM_005676.4	NP_001191396.1|NP_001191397.1|NP_005667.2	P98175	RBM10_HUMAN	RNA binding motif protein 10	674					mRNA processing|RNA splicing	chromatin remodeling complex	nucleotide binding|RNA binding|zinc ion binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(8)|large_intestine(10)|liver(1)|lung(14)|ovary(2)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	48						AAATAGCTTCCAGCCTATCAG	0.567000													19	14					0	0	1	0	0
SELENBP1	8991	broad.mit.edu	37	1	151341499	151341499	+	Missense_Mutation	SNP	C	C	A	rs150747769	by1000genomes	TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr1:151341499C>A	ENST00000435071.1	-	4	611	c.149G>T	c.(148-150)cGg>cTg	p.R50L	SELENBP1_ENST00000473693.1_5'UTR|SELENBP1_ENST00000368868.5_Missense_Mutation_p.R114L|SELENBP1_ENST00000447402.3_Intron|SELENBP1_ENST00000426705.2_Missense_Mutation_p.R156L			Q13228	SBP1_HUMAN	selenium binding protein 1	114					protein transport	cytosol|membrane|nucleolus	protein binding|selenium binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(11)|prostate(1)|urinary_tract(1)	20	Lung SC(34;0.00471)|Ovarian(49;0.00871)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)			CTTTGGGGCCCGGGGCTCAGA	0.607000													16	76					6.31663e-08	7.75931e-08	1	1	0
KCNQ2	3785	broad.mit.edu	37	20	62071028	62071028	+	Missense_Mutation	SNP	A	A	C			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr20:62071028A>C	ENST00000354587.3	-	6	1026	c.850T>G	c.(850-852)Tac>Gac	p.Y284D	KCNQ2_ENST00000360480.3_Missense_Mutation_p.Y284D|KCNQ2_ENST00000370226.1_Missense_Mutation_p.Y284D|KCNQ2_ENST00000370224.1_Missense_Mutation_p.Y284D|KCNQ2_ENST00000357249.2_Missense_Mutation_p.Y284D|KCNQ2_ENST00000359689.1_Missense_Mutation_p.Y284D|KCNQ2_ENST00000430658.1_Missense_Mutation_p.Y284D|KCNQ2_ENST00000370222.3_Missense_Mutation_p.Y284D|KCNQ2_ENST00000344425.5_Missense_Mutation_p.Y284D|KCNQ2_ENST00000359125.2_Missense_Mutation_p.Y284D|KCNQ2_ENST00000370221.1_Missense_Mutation_p.Y284D|KCNQ2_ENST00000344462.3_Missense_Mutation_p.Y284D			O43526	KCNQ2_HUMAN	potassium voltage-gated channel, KQT-like subfamily, member 2	284			Y -> C (in EBN1; 30%-60% reduction of wt heteromeric current. Ratio 1:1 or 20%- 30%; ratio of 1:1:2; dbSNP:rs28939683).		axon guidance|synaptic transmission	voltage-gated potassium channel complex	voltage-gated potassium channel activity			biliary_tract(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(4)|liver(1)|lung(30)|ovary(2)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)	65	all_cancers(38;1.24e-11)		BRCA - Breast invasive adenocarcinoma(10;1.04e-05)		Amitriptyline(DB00321)	GTCTGGGGGTACTTGTCCCCG	0.642000													14	61					0	0	1	0	0
ACTN1	87	broad.mit.edu	37	14	69376758	69376758	+	Splice_Site	SNP	C	C	G			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr14:69376758C>G	ENST00000193403.6	-	5	812	c.427_splice	c.e5-1	p.E143_splice	ACTN1_ENST00000376839.3_Splice_Site_p.E78_splice|ACTN1_ENST00000438964.2_Splice_Site_p.E143_splice|ACTN1_ENST00000394419.4_Splice_Site_p.E143_splice|ACTN1_ENST00000538545.2_Splice_Site_p.E143_splice|ACTN1_ENST00000554508.1_5'UTR	NM_001102.3	NP_001093.1	P12814	ACTN1_HUMAN	actinin, alpha 1	143	Actin-binding.				focal adhesion assembly|negative regulation of cellular component movement|platelet activation|platelet degranulation|regulation of apoptosis	actin cytoskeleton|cytosol|extracellular region|focal adhesion|nucleolus|platelet alpha granule lumen|pseudopodium|sarcomere	actin binding|calcium ion binding|integrin binding|vinculin binding			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(5)|lung(9)|prostate(2)|urinary_tract(1)	27				BRCA - Breast invasive adenocarcinoma(234;0.00605)|all cancers(60;0.00846)|OV - Ovarian serous cystadenocarcinoma(108;0.0654)		TGGCTGAAGTCTCTATGGGGA	0.572000													16	17					0	0	1	0	0
FBN1	2200	broad.mit.edu	37	15	48718047	48718047	+	Missense_Mutation	SNP	T	T	C			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr15:48718047T>C	ENST00000316623.5	-	59	7674	c.7219A>G	c.(7219-7221)Aag>Gag	p.K2407E		NM_000138.4	NP_000129.3	P35555	FBN1_HUMAN	fibrillin 1	2407	EGF-like 41; calcium-binding.				heart development|negative regulation of BMP signaling pathway by extracellular sequestering of BMP|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|skeletal system development	basement membrane|extracellular space|microfibril	calcium ion binding|extracellular matrix structural constituent|protein binding			NS(1)|breast(5)|cervix(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(43)|liver(1)|lung(49)|ovary(4)|pancreas(1)|prostate(9)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	139		all_lung(180;0.00279)		all cancers(107;4.24e-07)|GBM - Glioblastoma multiforme(94;1.41e-05)		TGAATAACCTTGCATTCATCG	0.328000													18	37					0	0	1	0	0
LOC101927209	101927209	broad.mit.edu	37	1	142713773	142713773	+	RNA	SNP	C	C	G			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr1:142713773C>G	ENST00000369381.2	-	0	832																											TCTTTTTCCACATTGTCATTT	0.284000													4	73					0	0	1	0	0
ZNF492	57615	broad.mit.edu	37	19	22847904	22847904	+	Missense_Mutation	SNP	A	A	T			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr19:22847904A>T	ENST00000456783.2	+	4	1677	c.1433A>T	c.(1432-1434)aAg>aTg	p.K478M		NM_020855.2	NP_065906.1	Q9P255	ZN492_HUMAN	zinc finger protein 492	478					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|kidney(1)|large_intestine(6)|lung(10)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	21		all_cancers(12;0.0266)|all_lung(12;0.00187)|Lung NSC(12;0.0019)|all_epithelial(12;0.00203)|Hepatocellular(1079;0.244)				AAACCCTACAAGTGTGAAGAA	0.388000													13	31					0	0	1	0	0
OMG	4974	broad.mit.edu	37	17	29622866	29622866	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr17:29622866G>T	ENST00000247271.4	-	2	745	c.484C>A	c.(484-486)Cca>Aca	p.P162T	NF1_ENST00000356175.3_Intron|NF1_ENST00000358273.4_Intron	NM_002544.4	NP_002535.3	P23515	OMGP_HUMAN	oligodendrocyte myelin glycoprotein	162					cell adhesion|negative regulation of axonogenesis|nerve growth factor receptor signaling pathway	anchored to membrane|plasma membrane		p.0?(8)|p.?(3)		breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(1)|ovary(1)|prostate(1)|stomach(1)	13		all_cancers(10;6.97e-11)|all_epithelial(10;0.0051)|all_hematologic(16;0.0149)|Breast(31;0.0155)|Myeloproliferative disorder(56;0.0255)|Acute lymphoblastic leukemia(14;0.0257)|all_lung(9;0.0468)|Lung NSC(157;0.094)		UCEC - Uterine corpus endometrioid carcinoma (4;6.64e-05)|all cancers(4;1.81e-13)|Epithelial(4;4.04e-12)|OV - Ovarian serous cystadenocarcinoma(4;9.49e-12)|GBM - Glioblastoma multiforme(4;0.121)		ATGTTGGTTGGAACTGTCCAA	0.383000													42	115					6.33695e-27	1.02525e-26	1	1	0
SMG1	23049	broad.mit.edu	37	16	18826847	18826847	+	Missense_Mutation	SNP	T	T	C			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr16:18826847T>C	ENST00000446231.2	-	59	10841	c.10429A>G	c.(10429-10431)Atg>Gtg	p.M3477V	SMG1_ENST00000389467.3_Missense_Mutation_p.M3478V			Q96Q15	SMG1_HUMAN	SMG1 phosphatidylinositol 3-kinase-related kinase	3477					DNA repair|mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|peptidyl-serine phosphorylation|phosphatidylinositol phosphorylation|protein autophosphorylation	cytoplasm|nucleus	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			NS(2)|breast(8)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(16)|lung(37)|ovary(1)|skin(1)|stomach(4)|urinary_tract(1)	92						ACCTGACCCATAGCCTGGACT	0.403000													28	67					0	0	1	0	0
PRSS35	167681	broad.mit.edu	37	6	84234289	84234289	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr6:84234289G>T	ENST00000536636.1	+	3	1474	c.1129G>T	c.(1129-1131)Gat>Tat	p.D377Y	PRSS35_ENST00000369700.3_Missense_Mutation_p.D377Y	NM_001170423.1	NP_001163894.1	Q8N3Z0	PRS35_HUMAN	protease, serine, 35	377	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			breast(2)|endometrium(2)|large_intestine(12)|lung(11)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	32		all_cancers(76;0.000113)|Acute lymphoblastic leukemia(125;1.09e-08)|all_hematologic(105;3.12e-05)|all_epithelial(107;0.0575)		BRCA - Breast invasive adenocarcinoma(397;0.0768)		CCAGTGGGTGGATGTCCACGG	0.527000													9	37					0.0581538	0.0596526	1	1	0
RAB3IP	117177	broad.mit.edu	37	12	70178569	70178569	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr12:70178569G>A	ENST00000550536.1	+	4	1085	c.628G>A	c.(628-630)Gaa>Aaa	p.E210K	RAB3IP_ENST00000551641.1_5'UTR|RAB3IP_ENST00000483530.2_Missense_Mutation_p.E194K|RAB3IP_ENST00000247833.7_Missense_Mutation_p.E194K|RAB3IP_ENST00000325555.9_5'UTR|RAB3IP_ENST00000362025.5_Missense_Mutation_p.E210K|RAB3IP_ENST00000378815.6_Missense_Mutation_p.E194K|RAB3IP_ENST00000553099.1_5'UTR	NM_001278402.1|NM_175623.2	NP_001265331.1|NP_783322.1	Q96QF0	RAB3I_HUMAN	RAB3A interacting protein	210					cilium assembly|Golgi to plasma membrane transport|protein localization to organelle|protein transport	actin cortical patch|centrosome|cytosol|lamellipodium|microtubule basal body|nucleus	guanyl-nucleotide exchange factor activity|protein binding			NS(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(11)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	22	Esophageal squamous(21;0.187)		Lung(24;0.000381)|OV - Ovarian serous cystadenocarcinoma(12;0.00168)|STAD - Stomach adenocarcinoma(21;0.00694)			ACAGGAATTGGAAGAACTCAC	0.343000													18	69					0	0	1	0	0
ZP1	22917	broad.mit.edu	37	11	60642986	60642986	+	Splice_Site	SNP	G	G	C			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr11:60642986G>C	ENST00000278853.5	+	12	1774		c.e12-1			NM_207341.2	NP_997224.2	P60852	ZP1_HUMAN	zona pellucida glycoprotein 1 (sperm receptor)						single fertilization	integral to membrane|plasma membrane|proteinaceous extracellular matrix				breast(3)|endometrium(2)|large_intestine(8)|lung(8)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	26						CTCTCTGACAGACTCCAATGG	0.592000													8	23					0	0	1	0	0
SRPX	8406	broad.mit.edu	37	X	38024106	38024106	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chrX:38024106C>A	ENST00000378533.3	-	5	675	c.569G>T	c.(568-570)cGc>cTc	p.R190L	SRPX_ENST00000544439.1_Missense_Mutation_p.R170L|SRPX_ENST00000343800.6_Missense_Mutation_p.R177L|SRPX_ENST00000432886.2_Missense_Mutation_p.R131L|TM4SF2_ENST00000465127.1_Intron|SRPX_ENST00000538295.1_Missense_Mutation_p.R190L	NM_006307.4	NP_006298.1	P78539	SRPX_HUMAN	sushi-repeat containing protein, X-linked	190	HYR.				cell adhesion	cell surface|membrane		p.R190H(1)		autonomic_ganglia(1)|breast(2)|endometrium(5)|large_intestine(5)|lung(10)|prostate(2)	25						TTCTGCAATGCGTTCCTTCAC	0.443000													11	10					3.07112e-06	3.57399e-06	1	1	0
XIRP2	129446	broad.mit.edu	37	2	168107682	168107682	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr2:168107682G>T	ENST00000409195.1	+	9	9869	c.9780G>T	c.(9778-9780)gaG>gaT	p.E3260D	XIRP2_ENST00000409043.1_Intron|XIRP2_ENST00000420519.1_Intron|XIRP2_ENST00000409756.2_Intron|XIRP2_ENST00000409728.1_Intron|XIRP2_ENST00000409605.1_Intron|XIRP2_ENST00000409273.1_Missense_Mutation_p.E3038D|XIRP2_ENST00000295237.9_Missense_Mutation_p.E3260D	NM_152381.5	NP_689594.4	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2	3085					actin cytoskeleton organization	cell junction	actin binding	p.E3260E(1)		NS(3)|biliary_tract(2)|breast(5)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(51)|lung(160)|ovary(7)|pancreas(3)|prostate(11)|skin(14)|stomach(5)|upper_aerodigestive_tract(8)|urinary_tract(7)	315						ACGCTCAAGAGGAAATCAGGA	0.423000													22	57					3.5997e-14	5.08043e-14	1	1	0
WFIKKN2	124857	broad.mit.edu	37	17	48917306	48917306	+	Missense_Mutation	SNP	G	G	C			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr17:48917306G>C	ENST00000311378.4	+	2	1185	c.657G>C	c.(655-657)caG>caC	p.Q219H	WFIKKN2_ENST00000426127.1_Missense_Mutation_p.Q126H	NM_175575.5	NP_783165.1	Q8TEU8	WFKN2_HUMAN	WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2	219	Ig-like C2-type.					extracellular region	metalloendopeptidase inhibitor activity|protein binding|serine-type endopeptidase inhibitor activity			cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(3)|lung(13)|ovary(4)|skin(1)	29			BRCA - Breast invasive adenocarcinoma(22;1.09e-08)			CTGTGCACCAGTCGGTCACCA	0.642000													13	48					0	0	1	0	0
KCNA4	3739	broad.mit.edu	37	11	30034020	30034020	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr11:30034020C>A	ENST00000328224.6	-	2	1439	c.206G>T	c.(205-207)gGg>gTg	p.G69V		NM_002233.3	NP_002224.1	P22459	KCNA4_HUMAN	potassium voltage-gated channel, shaker-related subfamily, member 4	69						voltage-gated potassium channel complex	potassium ion binding|protein binding|voltage-gated potassium channel activity			central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(17)|lung(39)|ovary(3)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(4)|urinary_tract(1)	78						GGTACAGGCCCCGCGTGACTG	0.657000													20	49					8.10497e-08	9.89503e-08	1	1	0
FLNC	2318	broad.mit.edu	37	7	128484144	128484144	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr7:128484144C>A	ENST00000325888.8	+	20	3277	c.3016C>A	c.(3016-3018)Ccc>Acc	p.P1006T	FLNC_ENST00000346177.6_Missense_Mutation_p.P1006T	NM_001458.4	NP_001449.3	Q14315	FLNC_HUMAN	filamin C, gamma	1006					cell junction assembly	cytoskeleton|cytosol|plasma membrane|sarcomere	actin binding			biliary_tract(1)|breast(7)|central_nervous_system(1)|cervix(1)|endometrium(19)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(19)|lung(59)|ovary(2)|pancreas(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)	128						GATGACTTCGCCCTCTCGCCG	0.662000													15	30					4.7546e-09	5.95073e-09	1	1	0
ATP8B1	5205	broad.mit.edu	37	18	55359055	55359055	+	Missense_Mutation	SNP	T	T	A			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr18:55359055T>A	ENST00000536015.1	-	12	1323	c.1204A>T	c.(1204-1206)Atc>Ttc	p.I402F	RP11-35G9.3_ENST00000599199.1_RNA|RP11-35G9.5_ENST00000588925.1_RNA|ATP8B1_ENST00000283684.4_Missense_Mutation_p.I402F	NM_005603.4	NP_005594.1	O43520	AT8B1_HUMAN	ATPase, aminophospholipid transporter, class I, type 8B, member 1	402					ATP biosynthetic process|bile acid and bile salt transport|negative regulation of transcription, DNA-dependent	apical plasma membrane|integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			breast(6)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(11)|lung(19)|ovary(3)|prostate(1)	53		Colorectal(73;0.229)				TAGAGAGAGATGGGTACCATG	0.443000													16	42					0	0	1	0	0
MICAL3	57553	broad.mit.edu	37	22	18300821	18300821	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr22:18300821C>A	ENST00000441493.2	-	26	4958	c.4606G>T	c.(4606-4608)Gac>Tac	p.D1536Y		NM_015241.2	NP_056056.2	Q7RTP6	MICA3_HUMAN	microtubule associated monooxygenase, calponin and LIM domain containing 3	1536						cytoplasm|cytoskeleton	monooxygenase activity|zinc ion binding			large_intestine(1)|lung(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	4		all_epithelial(15;0.198)		Lung(27;0.0427)		AGGCTTGAGTCCTCAGTCTTG	0.627000													8	22					0.00307968	0.00324263	1	1	0
FLG	2312	broad.mit.edu	37	1	152281717	152281717	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr1:152281717C>T	ENST00000368799.1	-	3	5680	c.5645G>A	c.(5644-5646)gGg>gAg	p.G1882E	FLG-AS1_ENST00000420707.1_RNA|FLG-AS1_ENST00000593011.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	1882	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GTGACGCGACCCTGAGTGCCT	0.577000									Ichthyosis				98	457					0	0	1	0	0
BAGE2	85319	broad.mit.edu	37	21	11038981	11038981	+	RNA	SNP	T	T	C			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr21:11038981T>C	ENST00000470054.1	-	0	1222									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		ATGATAACTTTATAGATTTGC	0.408000													27	451					0	0	1	0	0
ABI3BP	25890	broad.mit.edu	37	3	100567717	100567717	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr3:100567717G>T	ENST00000471714.1	-	18	1634	c.1525C>A	c.(1525-1527)Ccc>Acc	p.P509T	ABI3BP_ENST00000495063.1_Missense_Mutation_p.P509T|ABI3BP_ENST00000284322.5_Missense_Mutation_p.P460T			Q7Z7G0	TARSH_HUMAN	ABI family, member 3 (NESH) binding protein	460	Pro-rich.					extracellular space				central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|lung(18)|ovary(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	50						GTTTGCTGGGGAGCTGAAAGA	0.403000													12	46					3.07112e-06	3.57399e-06	1	1	0
RP11-423O2.5	0	broad.mit.edu	37	1	142803427	142803427	+	RNA	SNP	C	C	G			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr1:142803427C>G	ENST00000423385.1	-	0	1538																											ctcatcctctcaagtagtttg	0.343000													4	17					0	0	1	0	0
ARPC1B	10095	broad.mit.edu	37	7	98987630	98987630	+	Missense_Mutation	SNP	G	G	C			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr7:98987630G>C	ENST00000451682.1	+	7	804	c.495G>C	c.(493-495)aaG>aaC	p.K165N	ARPC1B_ENST00000252725.5_Missense_Mutation_p.K165N			O15143	ARC1B_HUMAN	actin related protein 2/3 complex, subunit 1B, 41kDa	165					cellular component movement|regulation of actin filament polymerization	Arp2/3 protein complex|cytoplasm	actin binding|structural constituent of cytoskeleton			central_nervous_system(1)|endometrium(2)|large_intestine(5)|liver(2)|lung(1)	11	all_cancers(62;3.49e-09)|all_epithelial(64;2.57e-10)|Lung NSC(181;0.0053)|all_lung(186;0.00895)|Esophageal squamous(72;0.0166)		STAD - Stomach adenocarcinoma(171;0.215)			GTGACTTCAAGTGTCGGTGAG	0.622000													37	80					0	0	1	0	0
C15orf41	84529	broad.mit.edu	37	15	37100595	37100595	+	Missense_Mutation	SNP	A	A	G			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr15:37100595A>G	ENST00000566621.1	+	11	1037	c.787A>G	c.(787-789)Atc>Gtc	p.I263V	C15orf41_ENST00000569302.1_Missense_Mutation_p.I269V|C15orf41_ENST00000562489.1_Missense_Mutation_p.I87V|CSNK1A1P1_ENST00000430593.3_RNA|C15orf41_ENST00000567389.1_Missense_Mutation_p.I165V|C15orf41_ENST00000562877.1_Missense_Mutation_p.I165V|C15orf41_ENST00000565792.1_3'UTR|C15orf41_ENST00000563167.1_Missense_Mutation_p.H25R|C15orf41_ENST00000338183.4_Missense_Mutation_p.I165V|C15orf41_ENST00000437989.2_Missense_Mutation_p.I263V	NM_001130010.1	NP_001123482.1	Q9Y2V0	CO041_HUMAN	chromosome 15 open reading frame 41	263							protein binding			kidney(1)|large_intestine(3)|lung(6)|ovary(1)|pancreas(1)	12		all_epithelial(112;3.06e-10)|Lung NSC(122;6.48e-08)|all_lung(180;8.31e-07)|Melanoma(134;0.222)		all cancers(64;1.76e-19)|GBM - Glioblastoma multiforme(113;5.03e-07)|BRCA - Breast invasive adenocarcinoma(123;0.11)		GGAAAGGGGCATCCTGCTCAA	0.478000													11	38					0	0	1	0	0
PCDH11X	27328	broad.mit.edu	37	X	91873486	91873486	+	Silent	SNP	C	C	T			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chrX:91873486C>T	ENST00000373094.1	+	7	4436	c.3591C>T	c.(3589-3591)caC>caT	p.H1197H	PCDH11X_ENST00000373097.1_Silent_p.H1187H|PCDH11X_ENST00000298274.8_Silent_p.H1160H|PCDH11X_ENST00000373088.1_Silent_p.H1160H|PCDH11X_ENST00000504220.1_3'UTR|PCDH11X_ENST00000406881.1_Silent_p.H1189H|PCDH11X_ENST00000361655.2_Silent_p.H1179H	NM_032968.3	NP_116750.1	Q9BZA7	PC11X_HUMAN	protocadherin 11 X-linked	1197					homophilic cell adhesion	integral to plasma membrane	calcium ion binding			NS(1)|autonomic_ganglia(1)|biliary_tract(1)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(30)|liver(4)|lung(92)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	159						CTCTCTGCCACAGCCCTCCAG	0.597000													8	87					0	0	1	0	0
SIGLEC9	27180	broad.mit.edu	37	19	51628630	51628630	+	Silent	SNP	C	C	T			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr19:51628630C>T	ENST00000440804.3	+	1	466	c.399C>T	c.(397-399)caC>caT	p.H133H	SIGLEC9_ENST00000250360.3_Silent_p.H133H	NM_001198558.1	NP_001185487.1	Q9Y336	SIGL9_HUMAN	sialic acid binding Ig-like lectin 9	133	Ig-like V-type.				cell adhesion|cell surface receptor linked signaling pathway	integral to plasma membrane	sugar binding			NS(1)|breast(1)|endometrium(3)|kidney(1)|large_intestine(6)|liver(3)|lung(25)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	45		all_neural(266;0.0529)		GBM - Glioblastoma multiforme(134;0.000826)|OV - Ovarian serous cystadenocarcinoma(262;0.00295)		ATAAACATCACCGGCTCTCTG	0.517000													14	43					0	0	1	0	0
SLC17A8	246213	broad.mit.edu	37	12	100806591	100806591	+	Silent	SNP	G	G	A			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr12:100806591G>A	ENST00000323346.5	+	10	1543	c.1230G>A	c.(1228-1230)tcG>tcA	p.S410S	SLC17A8_ENST00000392989.3_Silent_p.S360S|SLC17A8_ENST00000552697.1_3'UTR	NM_001145288.1|NM_139319.2	NP_001138760.1|NP_647480.1	Q8NDX2	VGLU3_HUMAN	solute carrier family 17 (vesicular glutamate transporter), member 8	410					neurotransmitter transport|sensory perception of sound|sodium ion transport	cell junction|integral to membrane|synaptic vesicle membrane|synaptosome	L-glutamate transmembrane transporter activity|symporter activity			NS(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(25)|ovary(3)|pancreas(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	44						TTGGCTTTTCGCATACCAAAG	0.448000													31	116					0	0	1	0	0
LOC93432	93432	broad.mit.edu	37	7	141896544	141896544	+	Missense_Mutation	SNP	G	G	C			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr7:141896544G>C	ENST00000477922.3	+	40	4614	c.4560G>C	c.(4558-4560)gaG>gaC	p.E1520D																	endometrium(1)|lung(5)	6						CTGAATATGAGATGTGTGTTC	0.483000													8	21					0	0	1	0	0
TEX11	56159	broad.mit.edu	37	X	70127661	70127661	+	Splice_Site	SNP	C	C	A			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chrX:70127661C>A	ENST00000395889.2	-	2	58		c.e2-1		TEX11_ENST00000374333.2_Splice_Site	NM_001003811.1	NP_001003811.1	Q8IYF3	TEX11_HUMAN	testis expressed 11								protein binding			breast(4)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(12)|lung(13)|ovary(3)|prostate(3)|skin(3)	48	Renal(35;0.156)					TGGCTCAAGCCTGTGAAATAA	0.338000													13	13					0.00010058	0.000111197	1	1	0
KMT2A	4297	broad.mit.edu	37	11	118339515	118339515	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr11:118339515C>T	ENST00000534358.1	+	2	481	c.458C>T	c.(457-459)tCa>tTa	p.S153L	KMT2A_ENST00000389506.5_Missense_Mutation_p.S153L|KMT2A_ENST00000354520.4_Missense_Mutation_p.S153L	NM_001197104.1|NM_005933.3	NP_001184033.1|NP_005924.2			lysine (K)-specific methyltransferase 2A																		GGTTTTGGCTCAGATGAAGAA	0.403000													22	51					0	0	1	0	0
GID4	79018	broad.mit.edu	37	17	17948473	17948473	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr17:17948473G>T	ENST00000268719.4	+	2	624	c.451G>T	c.(451-453)Ggg>Tgg	p.G151W	GID4_ENST00000376345.3_Missense_Mutation_p.G151W	NM_024052.4	NP_076957.3			GID complex subunit 4																		CGTGGACACGGGGAACTCTTA	0.473000													18	36					1.01871e-10	1.31639e-10	1	1	0
BCL11A	53335	broad.mit.edu	37	2	60689148	60689148	+	Missense_Mutation	SNP	A	A	T			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr2:60689148A>T	ENST00000335712.6	-	4	1126	c.899T>A	c.(898-900)gTg>gAg	p.V300E	BCL11A_ENST00000358510.4_Missense_Mutation_p.V266E|BCL11A_ENST00000356842.4_Missense_Mutation_p.V300E|BCL11A_ENST00000537768.1_Intron|BCL11A_ENST00000359629.5_Intron|BCL11A_ENST00000477659.1_5'UTR|BCL11A_ENST00000538214.1_Missense_Mutation_p.V266E	NM_022893.3	NP_075044.2	Q9H165	BC11A_HUMAN	B-cell CLL/lymphoma 11A (zinc finger protein)	300	Pro-rich.				negative regulation of axon extension|negative regulation of collateral sprouting|negative regulation of dendrite development|positive regulation of collateral sprouting|positive regulation of neuron projection development|positive regulation of transcription from RNA polymerase II promoter|protein sumoylation|regulation of dendrite development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	nucleic acid binding|protein heterodimerization activity|protein homodimerization activity|zinc ion binding			NS(1)|breast(6)|central_nervous_system(6)|endometrium(4)|kidney(1)|large_intestine(8)|lung(25)|ovary(2)|pancreas(1)|prostate(2)|skin(3)	59			LUSC - Lung squamous cell carcinoma(5;9.29e-08)|Lung(5;1.34e-06)|Epithelial(17;0.0562)|all cancers(80;0.199)			CAACCGCAGCACCCTGTCAAA	0.612000			T	IGH@	B-CLL								22	64					0	0	1	0	0
SPATA31D5P	347127	broad.mit.edu	37	9	84530312	84530312	+	RNA	SNP	G	G	A			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr9:84530312G>A	ENST00000527857.1	+	0	334					NR_026851.1																						TGCAGCTTTGGACCTCCTGCT	0.577000													4	11					0	0	1	0	0
BPIFA3	128861	broad.mit.edu	37	20	31811753	31811753	+	Silent	SNP	G	G	A			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr20:31811753G>A	ENST00000375454.3	+	2	474	c.264G>A	c.(262-264)caG>caA	p.Q88Q	BPIFA3_ENST00000490499.1_3'UTR|BPIFA3_ENST00000375452.3_Silent_p.Q88Q	NM_178466.3	NP_848561.2	Q9BQP9	SPLC3_HUMAN	BPI fold containing family A, member 3	88	Poly-Gln.					extracellular region	lipid binding										AACACCAGCAGCAGCAAGAGA	0.572000													4	68					0	0	1	0	0
ANKMY1	51281	broad.mit.edu	37	2	241420440	241420440	+	Missense_Mutation	SNP	T	T	C			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr2:241420440T>C	ENST00000391987.1	-	17	3059	c.2693A>G	c.(2692-2694)tAc>tGc	p.Y898C	ANKMY1_ENST00000401804.1_Missense_Mutation_p.Y987C|ANKMY1_ENST00000373318.2_Missense_Mutation_p.Y677C|ANKMY1_ENST00000373320.4_Missense_Mutation_p.Y668C|ANKMY1_ENST00000361678.4_Missense_Mutation_p.Y674C|ANKMY1_ENST00000272972.3_Missense_Mutation_p.Y898C|ANKMY1_ENST00000406958.1_Missense_Mutation_p.Y659C|ANKMY1_ENST00000403283.1_Missense_Mutation_p.Y800C			Q9P2S6	ANKY1_HUMAN	ankyrin repeat and MYND domain containing 1	898							zinc ion binding			central_nervous_system(1)|endometrium(5)|large_intestine(4)|lung(14)|ovary(1)|prostate(2)|skin(1)|urinary_tract(2)	30		all_epithelial(40;2.79e-15)|Breast(86;2.41e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0335)|Lung NSC(271;0.106)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;1.03e-30)|all cancers(36;4.78e-28)|OV - Ovarian serous cystadenocarcinoma(60;1.45e-14)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;7.8e-06)|Lung(119;0.00271)|LUSC - Lung squamous cell carcinoma(224;0.01)|Colorectal(34;0.0101)|COAD - Colon adenocarcinoma(134;0.0476)		CAGGATCCCGTAGCAGCGAGG	0.617000													16	63					0	0	1	0	0
CUBN	8029	broad.mit.edu	37	10	17156057	17156057	+	Silent	SNP	T	T	C			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr10:17156057T>C	ENST00000377833.4	-	8	917	c.852A>G	c.(850-852)caA>caG	p.Q284Q		NM_001081.3	NP_001072.2	O60494	CUBN_HUMAN	cubilin (intrinsic factor-cobalamin receptor)	284	EGF-like 3; calcium-binding (Potential).				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			breast(8)|central_nervous_system(4)|cervix(1)|endometrium(18)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(42)|liver(1)|lung(107)|ovary(9)|pancreas(2)|prostate(3)|skin(9)|stomach(3)|upper_aerodigestive_tract(11)|urinary_tract(8)	241					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	AGAAAGAGCCTTGAGTGTTGA	0.562000													4	16					0	0	1	0	0
OR2M5	127059	broad.mit.edu	37	1	248308583	248308583	+	Missense_Mutation	SNP	T	T	C			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr1:248308583T>C	ENST00000366476.1	+	1	134	c.134T>C	c.(133-135)aTg>aCg	p.M45T		NM_001004690.1	NP_001004690.1	A3KFT3	OR2M5_HUMAN	olfactory receptor, family 2, subfamily M, member 5	45					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(5)|kidney(2)|large_intestine(7)|liver(1)|lung(25)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	49	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0388)			AACTCTGTCATGGTTCTCCTC	0.522000													183	230					0	0	1	0	0
IGKV6D-41	28869	broad.mit.edu	37	2	90108542	90108542	+	RNA	SNP	T	T	C			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr2:90108542T>C	ENST00000390271.2	+	0	39																											GGTGTCCCCGTTGCAATTCCT	0.408000													17	57					0	0	1	0	0
DNM1P46	196968	broad.mit.edu	37	15	100340069	100340069	+	RNA	SNP	C	C	A			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr15:100340069C>A	ENST00000341853.1	-	0	857					NR_003260.1																						TCCGCCGACTCCTGCAGGAGT	0.602000													7	11					0.27861	0.282875	1	1	0
PDGFRB	5159	broad.mit.edu	37	5	149515374	149515374	+	Silent	SNP	T	T	A			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr5:149515374T>A	ENST00000261799.4	-	3	577	c.108A>T	c.(106-108)acA>acT	p.T36T		NM_002609.3	NP_002600.1	P09619	PGFRB_HUMAN	platelet-derived growth factor receptor, beta polypeptide	36	Ig-like C2-type 1.				aorta morphogenesis|cardiac myofibril assembly|hemopoiesis|metanephric glomerular capillary formation|metanephric glomerular mesangial cell proliferation involved in metanephros development|peptidyl-tyrosine phosphorylation|positive regulation of calcium ion import|positive regulation of chemotaxis|positive regulation of DNA biosynthetic process|positive regulation of ERK1 and ERK2 cascade|positive regulation of MAP kinase activity|positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway|positive regulation of mitosis|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of reactive oxygen species metabolic process|positive regulation of smooth muscle cell migration|positive regulation of smooth muscle cell proliferation|protein autophosphorylation|regulation of actin cytoskeleton organization|retina vasculature development in camera-type eye|smooth muscle cell chemotaxis	apical plasma membrane|cytoplasm|integral to plasma membrane|nucleus	ATP binding|platelet activating factor receptor activity|platelet-derived growth factor beta-receptor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|vascular endothelial growth factor receptor activity			breast(3)|central_nervous_system(5)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(9)|kidney(3)|large_intestine(12)|lung(20)|ovary(3)|prostate(3)|skin(3)|stomach(6)|urinary_tract(1)	75		all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)		Becaplermin(DB00102)|Dasatinib(DB01254)|Imatinib(DB00619)|Sorafenib(DB00398)|Sunitinib(DB01268)	GCCCCGGGGGTGTGACGACCA	0.592000			T	"""ETV6, TRIP11, HIP1, RAB5EP, H4, NIN, HCMOGT-1, PDE4DIP"""	"""MPD, AML, CMML, CML"""								12	39					0	0	1	0	0
SPANXN2	494119	broad.mit.edu	37	X	142795332	142795332	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chrX:142795332C>A	ENST00000370498.1	-	2	1099	c.346G>T	c.(346-348)Gac>Tac	p.D116Y		NM_001009615.1	NP_001009615.1	Q5MJ10	SPXN2_HUMAN	SPANX family, member N2	116										NS(1)|breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(17)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	27	Acute lymphoblastic leukemia(192;6.56e-05)					TCAGATGAGTCCAGGTCTTCG	0.517000													10	181					1.55795e-14	2.23044e-14	1	1	0
PCDHGA5	56110	broad.mit.edu	37	5	140746158	140746158	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr5:140746158C>A	ENST00000518069.1	+	1	2261	c.2261C>A	c.(2260-2262)tCc>tAc	p.S754Y	PCDHGB1_ENST00000523390.1_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGB2_ENST00000522605.1_Intron	NM_018918.2|NM_032054.1	NP_061741.1|NP_114443.1														endometrium(1)|kidney(1)|large_intestine(5)|lung(3)|ovary(5)|upper_aerodigestive_tract(3)	18			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CAGACCTATTCCCACGAGGTC	0.597000													50	187					5.57489e-27	9.09347e-27	1	1	0
XIRP2	129446	broad.mit.edu	37	2	168107683	168107683	+	Nonsense_Mutation	SNP	G	G	T			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr2:168107683G>T	ENST00000409195.1	+	9	9870	c.9781G>T	c.(9781-9783)Gaa>Taa	p.E3261*	XIRP2_ENST00000409043.1_Intron|XIRP2_ENST00000420519.1_Intron|XIRP2_ENST00000409756.2_Intron|XIRP2_ENST00000409728.1_Intron|XIRP2_ENST00000409605.1_Intron|XIRP2_ENST00000409273.1_Nonsense_Mutation_p.E3039*|XIRP2_ENST00000295237.9_Nonsense_Mutation_p.E3261*	NM_152381.5	NP_689594.4	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2	3086					actin cytoskeleton organization	cell junction	actin binding			NS(3)|biliary_tract(2)|breast(5)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(51)|lung(160)|ovary(7)|pancreas(3)|prostate(11)|skin(14)|stomach(5)|upper_aerodigestive_tract(8)|urinary_tract(7)	315						CGCTCAAGAGGAAATCAGGAA	0.423000													22	57					3.5997e-14	5.08043e-14	1	1	0
EEF2	1938	broad.mit.edu	37	19	3982008	3982008	+	Silent	SNP	G	G	T			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr19:3982008G>T	ENST00000309311.6	-	6	922	c.834C>A	c.(832-834)acC>acA	p.T278T		NM_001961.3	NP_001952.1	P13639	EF2_HUMAN	eukaryotic translation elongation factor 2	278						cytosol|ribonucleoprotein complex	GTP binding|GTPase activity|protein binding|translation elongation factor activity			endometrium(4)|large_intestine(4)|lung(6)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	21		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00461)|GBM - Glioblastoma multiforme(1328;0.0223)|STAD - Stomach adenocarcinoma(1328;0.18)		CTTCGGGGCTGGTGGCTGACT	0.607000													27	82					4.40665e-25	7.01538e-25	1	1	0
ZNF211	10520	broad.mit.edu	37	19	58152547	58152547	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr19:58152547G>T	ENST00000544273.1	+	5	1056	c.729G>T	c.(727-729)tgG>tgT	p.W243C	ZNF211_ENST00000299871.5_Missense_Mutation_p.W296C|ZNF211_ENST00000541801.1_Missense_Mutation_p.W222C|ZNF211_ENST00000420680.1_Missense_Mutation_p.W235C|ZNF211_ENST00000240731.4_Missense_Mutation_p.W244C|ZNF211_ENST00000391703.3_Missense_Mutation_p.W170C|ZNF211_ENST00000254182.7_Missense_Mutation_p.W222C|ZNF211_ENST00000347302.3_Missense_Mutation_p.W231C			Q13398	ZN211_HUMAN	zinc finger protein 211	231						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(8)|ovary(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	26		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		ATCACAACTGGGGAAAATGCA	0.448000													31	85					1.30897e-18	1.97337e-18	1	1	0
OR2L2	26246	broad.mit.edu	37	1	248201637	248201637	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr1:248201637G>T	ENST00000366479.2	+	1	164	c.68G>T	c.(67-69)gGc>gTc	p.G23V	OR2L13_ENST00000366478.2_Intron	NM_001004686.2	NP_001004686.1	Q8NH16	OR2L2_HUMAN	olfactory receptor, family 2, subfamily L, member 2	23					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(28)|ovary(1)|skin(4)|urinary_tract(1)	42	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0278)			TCAAGAATTGGCCTTTTCGTA	0.388000													45	185					9.84934e-19	1.50771e-18	1	1	0
ATP6V1C2	245973	broad.mit.edu	37	2	10922461	10922461	+	Missense_Mutation	SNP	T	T	A			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr2:10922461T>A	ENST00000381661.3	+	12	1125	c.1016T>A	c.(1015-1017)tTc>tAc	p.F339Y	ATP6V1C2_ENST00000272238.4_Missense_Mutation_p.F385Y	NM_144583.3	NP_653184.2	Q8NEY4	VATC2_HUMAN	ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C2	385					ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|insulin receptor signaling pathway|transferrin transport	cytosol|proton-transporting V-type ATPase, V1 domain				endometrium(2)|kidney(1)|large_intestine(3)|lung(8)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	19	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.191)			Epithelial(75;0.15)|OV - Ovarian serous cystadenocarcinoma(76;0.152)		AACTCTGTCTTCCGACATCTG	0.443000													15	56					0	0	1	0	0
FAIM2	23017	broad.mit.edu	37	12	50264295	50264295	+	Missense_Mutation	SNP	G	G	C			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr12:50264295G>C	ENST00000320634.3	-	12	1037	c.943C>G	c.(943-945)Cga>Gga	p.R315G	FAIM2_ENST00000550890.1_Missense_Mutation_p.R269G	NM_012306.3	NP_036438.2	Q9BWQ8	FAIM2_HUMAN	Fas apoptotic inhibitory molecule 2	315					anti-apoptosis|apoptosis	cell junction|integral to membrane|postsynaptic membrane				endometrium(2)|large_intestine(4)|lung(4)|ovary(2)|skin(2)	14						CCTCATTCTCGGTTAGTGCCA	0.537000													25	64					0	0	1	0	0
MYH7	4625	broad.mit.edu	37	14	23900847	23900847	+	Missense_Mutation	SNP	G	G	C			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr14:23900847G>C	ENST00000355349.3	-	8	841	c.679C>G	c.(679-681)Ctg>Gtg	p.L227V		NM_000257.2	NP_000248.2	P12883	MYH7_HUMAN	myosin, heavy chain 7, cardiac muscle, beta	227	Myosin head-like.		L -> V (in CMH1).		adult heart development|muscle filament sliding|regulation of heart rate|ventricular cardiac muscle tissue morphogenesis	focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(3)|breast(4)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(19)|lung(57)|ovary(5)|prostate(9)|skin(5)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(5)	137	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00725)		AAGGCCTCCAGAGCAGGGTTG	0.607000													34	124					0	0	1	0	0
SYT8	90019	broad.mit.edu	37	11	1857243	1857243	+	Missense_Mutation	SNP	G	G	A	rs907608	by1000genomes	TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr11:1857243G>A	ENST00000535046.1	+	4	842	c.842G>A	c.(841-843)cGg>cAg	p.R281Q	SYT8_ENST00000381968.3_Intron|SYT8_ENST00000341958.3_Intron|SYT8_ENST00000436964.2_Missense_Mutation_p.R129Q|SYT8_ENST00000483280.1_3'UTR			Q8NBV8	SYT8_HUMAN	synaptotagmin VIII	0	C2 2.					acrosomal vesicle|integral to membrane|plasma membrane|synaptic vesicle	transporter activity			breast(1)|large_intestine(1)|lung(2)|ovary(1)|skin(1)	6		all_epithelial(84;0.000138)|Breast(177;0.000962)|Ovarian(85;0.0014)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00136)|Lung(200;0.0681)|LUSC - Lung squamous cell carcinoma(625;0.082)		CAGGACCAGCGGTTCTGCGAG	0.682000													3	46					0	0	1	0	0
LILRA4	23547	broad.mit.edu	37	19	54848227	54848227	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr19:54848227G>T	ENST00000291759.4	-	6	1196	c.1140C>A	c.(1138-1140)ttC>ttA	p.F380L	AC008984.2_ENST00000507363.1_RNA	NM_012276.3	NP_036408.3	P59901	LIRA4_HUMAN	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 4	380	Ig-like C2-type 4.					integral to membrane	receptor activity			NS(2)|breast(1)|central_nervous_system(2)|endometrium(2)|large_intestine(5)|lung(13)|prostate(3)|skin(1)|upper_aerodigestive_tract(3)	32	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.0565)		GACTCATGGGGAATTCAGCCT	0.607000													47	141					5.2432e-18	7.78655e-18	1	1	0
TDRKH	11022	broad.mit.edu	37	1	151755442	151755442	+	Silent	SNP	C	C	A			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr1:151755442C>A	ENST00000368822.1	-	2	690	c.57G>T	c.(55-57)ctG>ctT	p.L19L	TDRKH_ENST00000484421.1_5'UTR|TDRKH_ENST00000458431.2_Silent_p.L19L|TDRKH_ENST00000368827.6_Silent_p.L19L|TDRKH_ENST00000368824.3_Silent_p.L19L|TDRKH_ENST00000440583.2_5'UTR|TDRKH_ENST00000368823.1_Silent_p.L19L|TDRKH_ENST00000368825.3_Silent_p.L19L			Q9Y2W6	TDRKH_HUMAN	tudor and KH domain containing	19							RNA binding			breast(5)|cervix(2)|endometrium(1)|kidney(1)|large_intestine(4)|lung(7)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	26	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.14)		LUSC - Lung squamous cell carcinoma(543;0.181)			TCCCAAGGCCCAGGGCTATTT	0.463000													39	130					6.57855e-14	9.15476e-14	1	1	0
PLEKHM1P	440456	broad.mit.edu	37	17	62820941	62820941	+	RNA	SNP	T	T	A			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr17:62820941T>A	ENST00000582986.1	-	0	188					NR_024386.1																						CAGGGACACGTACTGCTTTTG	0.532000													20	38					0	0	1	0	0
RLIM	51132	broad.mit.edu	37	X	73812447	73812447	+	Missense_Mutation	SNP	T	T	C			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chrX:73812447T>C	ENST00000332687.6	-	4	921	c.703A>G	c.(703-705)Atg>Gtg	p.M235V	RLIM_ENST00000349225.2_Missense_Mutation_p.M235V	NM_016120.3	NP_057204.2	Q9NVW2	RNF12_HUMAN	ring finger protein, LIM domain interacting	235					random inactivation of X chromosome|transcription, DNA-dependent|ubiquitin-dependent protein catabolic process	cytoplasm|transcriptional repressor complex	transcription corepressor activity|ubiquitin-protein ligase activity|zinc ion binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(3)|lung(14)|ovary(2)|prostate(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	30						ATTTCACTCATTGGATGCAGA	0.498000													36	17					0	0	1	0	0
PTPRD	5789	broad.mit.edu	37	9	8484343	8484343	+	Silent	SNP	C	C	A			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr9:8484343C>A	ENST00000381196.4	-	27	3732	c.3189G>T	c.(3187-3189)gtG>gtT	p.V1063V	PTPRD_ENST00000397611.3_Silent_p.V649V|PTPRD_ENST00000355233.5_Silent_p.V652V|PTPRD_ENST00000486161.1_Silent_p.V652V|PTPRD_ENST00000397617.3_Silent_p.V642V|PTPRD_ENST00000356435.5_Silent_p.V1063V|PTPRD_ENST00000540109.1_Silent_p.V1063V|PTPRD_ENST00000537002.1_Silent_p.V649V|PTPRD_ENST00000360074.4_Silent_p.V1050V|PTPRD_ENST00000397606.3_Silent_p.V642V|PTPRD_ENST00000358503.5_Silent_p.V1041V	NM_002839.3	NP_002830.1	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	1063	Fibronectin type-III 8.				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(7)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|liver(1)|lung(83)|ovary(4)|pancreas(1)|prostate(7)|skin(19)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	168		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		CTCGGCCATCCACTTCTTCTA	0.378000										TSP Lung(15;0.13)			11	29					3.86212e-05	4.36683e-05	1	1	0
CDC27	996	broad.mit.edu	37	17	45219283	45219283	+	Missense_Mutation	SNP	T	T	C	rs76995821		TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr17:45219283T>C	ENST00000066544.3	-	12	1580	c.1487A>G	c.(1486-1488)tAc>tGc	p.Y496C	CDC27_ENST00000527547.1_Missense_Mutation_p.Y495C|CDC27_ENST00000446365.2_Missense_Mutation_p.Y435C|CDC27_ENST00000531206.1_Missense_Mutation_p.Y502C	NM_001114091.1|NM_001256.3	NP_001107563.1|NP_001247.3	P30260	CDC27_HUMAN	cell division cycle 27	496			Y -> H (in dbSNP:rs13666).		anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell proliferation|mitotic cell cycle spindle assembly checkpoint|mitotic metaphase/anaphase transition|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination	anaphase-promoting complex|centrosome|cytosol|nucleoplasm|spindle microtubule	protein phosphatase binding			NS(1)|breast(5)|central_nervous_system(3)|cervix(1)|endometrium(2)|kidney(17)|large_intestine(18)|lung(11)|ovary(5)|pancreas(1)|prostate(19)|skin(5)|upper_aerodigestive_tract(2)	90						ACCAGTATTGTAGTGGTGAGA	0.373000													46	127					0	0	1	0	0
MAPK13	5603	broad.mit.edu	37	6	36104692	36104692	+	Missense_Mutation	SNP	T	T	C			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr6:36104692T>C	ENST00000211287.4	+	8	909	c.647T>C	c.(646-648)aTg>aCg	p.M216T	MAPK13_ENST00000373766.5_Intron|MAPK13_ENST00000373761.6_Missense_Mutation_p.M206T|MAPK13_ENST00000373759.1_Intron	NM_002754.4	NP_002745.1	O15264	MK13_HUMAN	mitogen-activated protein kinase 13	216	Protein kinase.				cell cycle|intracellular protein kinase cascade|nerve growth factor receptor signaling pathway|positive regulation of interleukin-6 production|Ras protein signal transduction|response to stress		ATP binding|MAP kinase activity|protein binding			breast(2)|central_nervous_system(1)|kidney(2)|large_intestine(2)|lung(2)|prostate(2)|skin(1)	12						ATGGCAGAGATGCTGACAGGG	0.507000													22	60					0	0	1	0	0
EVX2	344191	broad.mit.edu	37	2	176948244	176948244	+	Silent	SNP	G	G	T			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr2:176948244G>T	ENST00000308618.4	-	1	397	c.261C>A	c.(259-261)acC>acA	p.T87T		NM_001080458.1	NP_001073927.1	Q03828	EVX2_HUMAN	even-skipped homeobox 2	87						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			kidney(1)|large_intestine(3)|liver(1)|lung(8)|ovary(3)	16			OV - Ovarian serous cystadenocarcinoma(117;0.0207)|Epithelial(96;0.18)	READ - Rectum adenocarcinoma(9;0.0678)|Colorectal(32;0.115)		CGGAGGAGACGGTGCTTTCGC	0.627000													13	41					6.72482e-11	8.9216e-11	1	1	0
PPARA	5465	broad.mit.edu	37	22	46627756	46627756	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr22:46627756C>T	ENST00000396000.2	+	7	1044	c.779C>T	c.(778-780)gCc>gTc	p.A260V	PPARA_ENST00000434345.2_3'UTR|PPARA_ENST00000262735.5_Missense_Mutation_p.A260V|PPARA_ENST00000407236.1_Missense_Mutation_p.A260V|PPARA_ENST00000402126.1_Missense_Mutation_p.A260V			Q07869	PPARA_HUMAN	peroxisome proliferator-activated receptor alpha	260					fatty acid metabolic process|fatty acid transport|negative regulation of appetite|negative regulation of cholesterol storage|negative regulation of macrophage derived foam cell differentiation|negative regulation of receptor biosynthetic process|negative regulation of sequestering of triglyceride|negative regulation of transcription from RNA polymerase II promoter|positive regulation of fatty acid beta-oxidation|regulation of cellular ketone metabolic process by positive regulation of transcription from an RNA polymerase II promoter|regulation of glycolysis by positive regulation of transcription from an RNA polymerase II promoter|regulation of lipid transport by positive regulation of transcription from an RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	drug binding|ligand-regulated transcription factor activity|lipid binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|ubiquitin conjugating enzyme binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(5)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	15		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00522)	Atorvastatin(DB01076)|Bezafibrate(DB01393)|Clofibrate(DB00636)|Fenofibrate(DB01039)|Gemfibrozil(DB01241)|Simvastatin(DB00641)	AAGCTGGTGGCCAATGGCATC	0.552000													8	27					0	0	1	0	0
CHST14	113189	broad.mit.edu	37	15	40764364	40764364	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr15:40764364C>T	ENST00000306243.5	+	1	1205	c.952C>T	c.(952-954)Cac>Tac	p.H318Y	CHST14_ENST00000559991.1_Missense_Mutation_p.H293Y	NM_130468.3	NP_569735.1	Q8NCH0	CHSTE_HUMAN	carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 14	318					carbohydrate biosynthetic process|dermatan sulfate proteoglycan metabolic process	Golgi membrane|integral to membrane	N-acetylgalactosamine 4-O-sulfotransferase activity|phosphate binding			cervix(1)|large_intestine(1)|prostate(2)	4		all_cancers(109;2.34e-14)|all_epithelial(112;1.08e-11)|Lung NSC(122;2.95e-09)|all_lung(180;6.03e-08)|Melanoma(134;0.091)|Colorectal(260;0.198)|Ovarian(310;0.243)		GBM - Glioblastoma multiforme(113;3e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0781)		GGCACCACCTCACGTCCGATT	0.627000													22	59					0	0	1	0	0
PRX	57716	broad.mit.edu	37	19	40902282	40902282	+	Silent	SNP	G	G	A			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr19:40902282G>A	ENST00000324001.7	-	7	2247	c.1977C>T	c.(1975-1977)ctC>ctT	p.L659L	PRX_ENST00000291825.7_3'UTR	NM_181882.2	NP_870998.2	Q9BXM0	PRAX_HUMAN	periaxin	659	55 X 5 AA approximate tandem repeats of [LVMAG]-[PSREQC]-[EDKL]-[LIVMAP]- [AQKHRPE]; that may have a tripeptide spacer of [LV]-P-[KER].				axon ensheathment	cytoplasm|nucleus|plasma membrane	protein binding			breast(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(7)|lung(12)|ovary(2)|prostate(3)|skin(1)|urinary_tract(9)	47			Lung(22;6.24e-05)|LUSC - Lung squamous cell carcinoma(20;0.000384)			GGACTTTCGGGAGCTGCACTT	0.562000													6	177					0	0	1	0	0
OR4N2	390429	broad.mit.edu	37	14	20296223	20296223	+	Missense_Mutation	SNP	A	A	G	rs79084933		TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr14:20296223A>G	ENST00000315947.1	+	1	616	c.616A>G	c.(616-618)Atg>Gtg	p.M206V	OR4N2_ENST00000568211.1_3'UTR	NM_001004723.1	NP_001004723.1	Q8NGD1	OR4N2_HUMAN	olfactory receptor, family 4, subfamily N, member 2	206					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|liver(1)|lung(32)|ovary(2)|prostate(1)|skin(2)|stomach(2)	52	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		CAGTGGCCTGATGACACTCCT	0.522000													36	161					0	0	1	0	0
COL4A4	1286	broad.mit.edu	37	2	227896701	227896701	+	Silent	SNP	T	T	A			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr2:227896701T>A	ENST00000396625.3	-	40	3984	c.3777A>T	c.(3775-3777)ccA>ccT	p.P1259P	COL4A4_ENST00000329662.7_Silent_p.P1259P	NM_000092.4	NP_000083.3	P53420	CO4A4_HUMAN	collagen, type IV, alpha 4	1259	Triple-helical region.				axon guidance|glomerular basement membrane development	basal lamina|collagen type IV	extracellular matrix structural constituent|protein binding			breast(2)|central_nervous_system(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(15)|lung(35)|ovary(5)|pancreas(3)|prostate(2)|skin(12)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	98		Renal(207;0.00844)|all_lung(227;0.0187)|Lung NSC(271;0.0879)|all_hematologic(139;0.21)|Esophageal squamous(248;0.242)		Epithelial(121;6.7e-11)|all cancers(144;5.39e-08)|Lung(261;0.0132)|LUSC - Lung squamous cell carcinoma(224;0.0181)		GATCTCCAGGTGGACCCGGGT	0.537000													9	25					0	0	1	0	0
CRISP3	10321	broad.mit.edu	37	6	49704130	49704130	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr6:49704130G>T	ENST00000433368.2	-	3	301	c.232C>A	c.(232-234)Ccc>Acc	p.P78T	CRISP3_ENST00000393666.1_Missense_Mutation_p.P55T|CRISP3_ENST00000423399.2_Intron|CRISP3_ENST00000371159.4_Missense_Mutation_p.P86T|CRISP3_ENST00000263045.4_Missense_Mutation_p.P68T	NM_001190986.1	NP_001177915.1	P54108	CRIS3_HUMAN	cysteine-rich secretory protein 3	55					innate immune response	proteinaceous extracellular matrix|specific granule				breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(14)|skin(6)|upper_aerodigestive_tract(1)	27	Lung NSC(77;0.0161)		KIRC - Kidney renal clear cell carcinoma(2;0.106)|Kidney(12;0.156)			CTGGCAGGGGGAGATACTGCT	0.468000													50	117					2.81731e-22	4.34608e-22	1	1	0
NBEA	26960	broad.mit.edu	37	13	36167537	36167537	+	Translation_Start_Site	SNP	G	G	A	rs116439886	by1000genomes	TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr13:36167537G>A	ENST00000379922.3	+	0	395				NBEA_ENST00000379939.2_Missense_Mutation_p.V2414I|NBEA_ENST00000537702.1_Missense_Mutation_p.V210I|NBEA_ENST00000540320.1_Missense_Mutation_p.V2417I|NBEA_ENST00000400445.3_Missense_Mutation_p.V2417I|NBEA_ENST00000310336.4_Missense_Mutation_p.V2417I			Q8NFP9	NBEA_HUMAN	neurobeachin							cytosol|endomembrane system|plasma membrane|trans-Golgi network	protein binding			NS(1)|breast(1)|endometrium(14)|kidney(4)|large_intestine(29)|lung(40)|ovary(9)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	108		Breast(139;0.0141)|Lung SC(185;0.0548)|Prostate(109;0.207)		all cancers(112;1.93e-08)|Epithelial(112;1.62e-07)|BRCA - Breast invasive adenocarcinoma(63;0.00033)|OV - Ovarian serous cystadenocarcinoma(117;0.00109)|KIRC - Kidney renal clear cell carcinoma(186;0.00575)|Kidney(163;0.00656)|GBM - Glioblastoma multiforme(144;0.191)|Lung(94;0.199)		CTTCTCATCCGTTGCAAGGTC	0.338000													17	67					0	0	1	0	0
IGHV1-2	28474	broad.mit.edu	37	14	106452746	106452746	+	RNA	SNP	G	G	T			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr14:106452746G>T	ENST00000390594.2	-	0	339																											TGATGGACGTGTCCCTGGTCA	0.547000													60	98					1.73933e-33	2.93327e-33	1	1	0
H2AFY	9555	broad.mit.edu	37	5	134679002	134679002	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr5:134679002C>A	ENST00000511689.1	-	8	1494	c.901G>T	c.(901-903)Gct>Tct	p.A301S	CTC-203F4.1_ENST00000432382.3_Missense_Mutation_p.A95D|H2AFY_ENST00000510038.1_Missense_Mutation_p.A301S|H2AFY_ENST00000312469.4_Missense_Mutation_p.A298S|H2AFY_ENST00000423969.2_Missense_Mutation_p.A129S|H2AFY_ENST00000512507.1_5'UTR|CTC-203F4.1_ENST00000555438.1_Intron|H2AFY_ENST00000304332.4_Missense_Mutation_p.A300S	NM_001040158.1|NM_138610.2	NP_001035248.1|NP_613258.2	O75367	H2AY_HUMAN	H2A histone family, member Y	301	Macro.				chromatin modification|dosage compensation|nucleosome assembly	Barr body|nucleosome	DNA binding			endometrium(3)|large_intestine(3)|lung(3)|ovary(1)|urinary_tract(1)	11			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			TTATCATCAGCCAGGGCCAAG	0.498000													70	89					5.45122e-27	8.96524e-27	1	1	0
NNT	23530	broad.mit.edu	37	5	43616166	43616166	+	Splice_Site	SNP	G	G	T			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr5:43616166G>T	ENST00000264663.5	+	4	819	c.599_splice	c.e4+1	p.G200_splice	NNT_ENST00000344920.4_Splice_Site_p.G200_splice|NNT_ENST00000512996.2_Splice_Site_p.G69_splice	NM_012343.3	NP_036475.3	Q13423	NNTM_HUMAN	nicotinamide nucleotide transhydrogenase	200					tricarboxylic acid cycle	integral to membrane|mitochondrial respiratory chain	NAD binding|NAD(P)+ transhydrogenase (AB-specific) activity|NAD(P)+ transhydrogenase (B-specific) activity|NADP binding			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(7)|large_intestine(6)|liver(2)|lung(20)|ovary(3)|prostate(2)|skin(1)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	51	Lung NSC(6;2.58e-06)				NADH(DB00157)	CAACATTGCGGGGTAGGTTCT	0.413000													27	72					4.87955e-14	6.83825e-14	1	1	0
PRUNE2	158471	broad.mit.edu	37	9	79325166	79325166	+	Missense_Mutation	SNP	T	T	C			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr9:79325166T>C	ENST00000428286.1	-	8	2147	c.947A>G	c.(946-948)gAa>gGa	p.E316G	PRUNE2_ENST00000376718.3_Missense_Mutation_p.E675G			Q8WUY3	PRUN2_HUMAN	prune homolog 2 (Drosophila)	675					apoptosis|G1 phase|induction of apoptosis	cytoplasm	metal ion binding|pyrophosphatase activity			endometrium(1)|kidney(4)|large_intestine(3)|lung(7)|prostate(1)	16						AGATTCCTGTTCACTGGAACT	0.498000													15	42					0	0	1	0	0
OR5R1	219479	broad.mit.edu	37	11	56185334	56185334	+	Silent	SNP	G	G	T			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr11:56185334G>T	ENST00000312253.1	-	1	374	c.375C>A	c.(373-375)gcC>gcA	p.A125A		NM_001004744.1	NP_001004744.1	Q8NH85	OR5R1_HUMAN	olfactory receptor, family 5, subfamily R, member 1	125					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|liver(1)|lung(17)|ovary(2)|prostate(3)|stomach(1)|upper_aerodigestive_tract(1)	37	Esophageal squamous(21;0.00448)					GACTACAGATGGCGACATAGC	0.468000													15	74					2.32078e-09	2.92301e-09	1	1	0
VAV1	7409	broad.mit.edu	37	19	6772930	6772930	+	Silent	SNP	C	C	A			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr19:6772930C>A	ENST00000304076.2	+	1	206	c.112C>A	c.(112-114)Cgg>Agg	p.R38R	VAV1_ENST00000602142.1_Silent_p.R38R|VAV1_ENST00000596764.1_Silent_p.R38R	NM_001258206.1	NP_001245135.1	P15498	VAV_HUMAN	vav 1 guanine nucleotide exchange factor	38	CH.|Leu-rich.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|platelet activation|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|T cell costimulation	cytosol|plasma membrane	metal ion binding|protein binding|sequence-specific DNA binding transcription factor activity			biliary_tract(1)|breast(3)|central_nervous_system(2)|endometrium(3)|kidney(5)|large_intestine(16)|lung(18)|ovary(5)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)	62						CCAGGCCCTCCGGGATGGTGT	0.652000													19	70					4.96729e-08	6.13969e-08	1	1	0
ZNF804A	91752	broad.mit.edu	37	2	185801843	185801843	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr2:185801843G>T	ENST00000302277.6	+	4	2314	c.1720G>T	c.(1720-1722)Gat>Tat	p.D574Y		NM_194250.1	NP_919226.1	Q7Z570	Z804A_HUMAN	zinc finger protein 804A	574						intracellular	zinc ion binding	p.D574Y(1)		NS(5)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(22)|liver(2)|lung(79)|ovary(7)|pancreas(1)|prostate(2)|skin(12)|urinary_tract(1)	146						GGACACTCTAGATGAAAAATA	0.299000													15	45					3.41278e-10	4.38157e-10	1	1	0
HKDC1	80201	broad.mit.edu	37	10	71026381	71026381	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr10:71026381G>T	ENST00000354624.5	+	18	2755	c.2622G>T	c.(2620-2622)ttG>ttT	p.L874F	RP11-227H15.5_ENST00000413220.1_RNA	NM_025130.3	NP_079406.3	Q2TB90	HKDC1_HUMAN	hexokinase domain containing 1	874					glycolysis	mitochondrion|nucleus	ATP binding|hexokinase activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(11)|ovary(5)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	34						CTAGAATATTGCAGGAAACTG	0.403000													25	88					7.01153e-11	9.24037e-11	1	1	0
FAT2	2196	broad.mit.edu	37	5	150947209	150947209	+	Silent	SNP	G	G	A			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr5:150947209G>A	ENST00000261800.5	-	1	1296	c.1284C>T	c.(1282-1284)caC>caT	p.H428H		NM_001447.2	NP_001438.1	Q9NYQ8	FAT2_HUMAN	FAT atypical cadherin 2	428	Cadherin 3.				epithelial cell migration|homophilic cell adhesion	cell-cell adherens junction|integral to membrane|nucleus	calcium ion binding			NS(6)|breast(3)|central_nervous_system(3)|cervix(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(61)|liver(1)|lung(60)|ovary(6)|prostate(5)|skin(5)|stomach(2)|upper_aerodigestive_tract(11)|urinary_tract(1)	196		Medulloblastoma(196;0.0912)|all_hematologic(541;0.104)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			GTAGCTGATAGTGGGCTCTGT	0.498000													39	124					0	0	1	0	0
OAS1	4938	broad.mit.edu	37	12	113357335	113357335	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr12:113357335G>A	ENST00000202917.5	+	6	1443	c.1180G>A	c.(1180-1182)Gac>Aac	p.D394N	OAS1_ENST00000551241.1_Intron|RP1-71H24.1_ENST00000552784.1_RNA|OAS1_ENST00000445409.2_Missense_Mutation_p.G361E	NM_016816.2	NP_058132.2	P00973	OAS1_HUMAN	2'-5'-oligoadenylate synthetase 1, 40/46kDa	394					interferon-gamma-mediated signaling pathway|nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|type I interferon-mediated signaling pathway	endoplasmic reticulum|microsome|mitochondrion|nucleus	ATP binding|nucleotidyltransferase activity|RNA binding			cervix(1)|endometrium(3)|kidney(1)|large_intestine(2)|liver(2)|lung(4)|ovary(2)|skin(1)	16						GGCAGAAGAGGACTGGACCTG	0.507000													14	69					0	0	1	0	0
TEX35	84066	broad.mit.edu	37	1	178485002	178485002	+	Silent	SNP	C	C	G			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr1:178485002C>G	ENST00000367641.3	+	4	227	c.168C>G	c.(166-168)ctC>ctG	p.L56L	TEX35_ENST00000367642.3_Intron|TEX35_ENST00000367643.3_Silent_p.L56L|TEX35_ENST00000319416.2_Silent_p.L56L|TEX35_ENST00000258298.2_5'UTR|TEX35_ENST00000367639.1_Silent_p.L64L					testis expressed 35																		AGAATGAACTCAGGGAAGTGA	0.433000													12	24					0	0	1	0	0
GLI3	2737	broad.mit.edu	37	7	42063167	42063167	+	Missense_Mutation	SNP	T	T	C			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr7:42063167T>C	ENST00000395925.3	-	10	1481	c.1397A>G	c.(1396-1398)gAc>gGc	p.D466G	GLI3_ENST00000479210.1_5'UTR	NM_000168.5	NP_000159.3	P10071	GLI3_HUMAN	GLI family zinc finger 3	466					negative regulation of alpha-beta T cell differentiation|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of smoothened signaling pathway|negative regulation of transcription from RNA polymerase II promoter|negative thymic T cell selection|positive regulation of alpha-beta T cell differentiation|positive regulation of transcription from RNA polymerase II promoter|thymocyte apoptosis	cilium|cytosol|nucleolus	beta-catenin binding|histone acetyltransferase binding|histone deacetylase binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(2)|biliary_tract(1)|breast(4)|central_nervous_system(2)|endometrium(12)|kidney(7)|large_intestine(25)|lung(49)|ovary(3)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	112						TTCATCTTTGTCCCCTTCCTC	0.542000									Pallister-Hall syndrome;Greig Cephalopolysyndactyly				15	68					0	0	1	0	0
PCDHB14	56122	broad.mit.edu	37	5	140604499	140604499	+	Missense_Mutation	SNP	C	C	G			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr5:140604499C>G	ENST00000239449.4	+	1	1422	c.1422C>G	c.(1420-1422)agC>agG	p.S474R	PCDHB14_ENST00000515856.2_Missense_Mutation_p.S321R	NM_018934.2	NP_061757.1	Q9Y5E9	PCDBE_HUMAN		474	Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(21)|ovary(2)|prostate(3)|skin(6)|urinary_tract(1)	49			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GCAGCGTCAGCGCCACAGACA	0.637000													99	194					0	0	1	0	0
OR51G2	81282	broad.mit.edu	37	11	4936874	4936874	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr11:4936874C>A	ENST00000322013.3	-	1	48	c.20G>T	c.(19-21)gGa>gTa	p.G7V	MMP26_ENST00000380390.1_Intron|MMP26_ENST00000477339.1_Intron	NM_001005238.1	NP_001005238.1	Q8NGK0	O51G2_HUMAN	olfactory receptor, family 51, subfamily G, member 2	7					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			autonomic_ganglia(1)|endometrium(1)|large_intestine(9)|lung(12)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;5.06e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00438)|LUSC - Lung squamous cell carcinoma(625;0.19)		GCTGCTGTTTCCCAGGGATCC	0.547000													18	43					5.3912e-06	6.2375e-06	1	1	0
KGFLP2	654466	broad.mit.edu	37	9	41962730	41962730	+	RNA	SNP	A	A	G			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr9:41962730A>G	ENST00000454645.1	-	0	774					NR_003670.1																						TGAAGTTACAATCTTCATTGC	0.353000													4	26					0	0	1	0	0
FRMPD1	22844	broad.mit.edu	37	9	37745408	37745408	+	Nonsense_Mutation	SNP	G	G	T			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr9:37745408G>T	ENST00000539465.1	+	16	3972	c.3379G>T	c.(3379-3381)Gag>Tag	p.E1127*	FRMPD1_ENST00000377765.3_Nonsense_Mutation_p.E1127*|RP11-613M10.9_ENST00000540557.1_Intron			Q5SYB0	FRPD1_HUMAN	FERM and PDZ domain containing 1	1127						cytoskeleton|cytosol|plasma membrane				NS(3)|breast(2)|central_nervous_system(2)|endometrium(5)|kidney(4)|large_intestine(22)|lung(34)|ovary(5)|prostate(3)|skin(8)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	93				GBM - Glioblastoma multiforme(29;0.00655)		CGTATTTCAGGAGGAGTCTAG	0.428000													14	53					1.3612e-06	1.62203e-06	1	1	0
SPTA1	6708	broad.mit.edu	37	1	158623075	158623075	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr1:158623075C>A	ENST00000368148.3	-	22	3357	c.3177G>T	c.(3175-3177)caG>caT	p.Q1059H	SPTA1_ENST00000368147.3_Missense_Mutation_p.Q1059H	NM_003126.2	NP_003117.2	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1 (elliptocytosis 2)	1059					actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			NS(3)|breast(7)|cervix(1)|endometrium(22)|kidney(9)|large_intestine(29)|liver(2)|lung(183)|ovary(5)|prostate(18)|skin(11)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(6)	307	all_hematologic(112;0.0378)					GGTTCTCAATCTGCTCCTGGC	0.517000													34	160					6.04917e-29	1.00315e-28	1	1	0
ATP13A4	84239	broad.mit.edu	37	3	193210752	193210752	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr3:193210752G>T	ENST00000342695.4	-	5	809	c.487C>A	c.(487-489)Cat>Aat	p.H163N	ATP13A4_ENST00000295548.3_Missense_Mutation_p.H163N|ATP13A4_ENST00000392443.3_Missense_Mutation_p.H163N	NM_032279.2	NP_115655.2	Q4VNC1	AT134_HUMAN	ATPase type 13A4	163					ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(9)|lung(27)|ovary(2)|prostate(3)|skin(11)|upper_aerodigestive_tract(2)	71	all_cancers(143;1.76e-08)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(49;2.72e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;0.000109)		AATTTTTGATGTATCTTGGCA	0.308000													7	38					8.12818e-05	9.08713e-05	1	1	0
GRB10	2887	broad.mit.edu	37	7	50694650	50694650	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr7:50694650C>T	ENST00000403097.1	-	7	1292	c.512G>A	c.(511-513)gGg>gAg	p.G171E	GRB10_ENST00000401949.1_Missense_Mutation_p.G177E|GRB10_ENST00000398812.2_Missense_Mutation_p.G177E|GRB10_ENST00000402578.1_Missense_Mutation_p.G119E|GRB10_ENST00000402497.1_Missense_Mutation_p.G119E|GRB10_ENST00000335866.3_Missense_Mutation_p.G119E|GRB10_ENST00000407526.1_Missense_Mutation_p.G119E|GRB10_ENST00000406641.1_Missense_Mutation_p.G119E|GRB10_ENST00000398810.2_Missense_Mutation_p.G119E|GRB10_ENST00000439599.1_Missense_Mutation_p.G171E|GRB10_ENST00000357271.5_Missense_Mutation_p.G177E			Q13322	GRB10_HUMAN	growth factor receptor-bound protein 10	177	Ras-associating.				insulin receptor signaling pathway|negative regulation of glucose import|negative regulation of glycogen biosynthetic process|negative regulation of insulin receptor signaling pathway|negative regulation of Wnt receptor signaling pathway|positive regulation of phosphorylation|positive regulation of vascular endothelial growth factor receptor signaling pathway	cytosol|plasma membrane	insulin receptor binding|SH3/SH2 adaptor activity			NS(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(2)|lung(19)|ovary(3)|skin(3)|upper_aerodigestive_tract(2)	41	Glioma(55;0.08)|all_neural(89;0.245)					TTTGCTTGTCCCATCTTCACT	0.413000									Russell-Silver syndrome				60	181					0	0	1	0	0
USP47	55031	broad.mit.edu	37	11	11964407	11964407	+	Missense_Mutation	SNP	A	A	T			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr11:11964407A>T	ENST00000339865.5	+	19	3398	c.2635A>T	c.(2635-2637)Agc>Tgc	p.S879C	USP47_ENST00000399455.2_Missense_Mutation_p.S967C|USP47_ENST00000527733.1_Missense_Mutation_p.S947C|USP47_ENST00000539466.1_5'UTR	NM_017944.3	NP_060414.3	Q96K76	UBP47_HUMAN	ubiquitin specific peptidase 47	967					base-excision repair|cellular response to UV|monoubiquitinated protein deubiquitination|negative regulation of apoptosis|negative regulation of caspase activity|negative regulation of G2/M transition of mitotic cell cycle|negative regulation of transcription, DNA-dependent|positive regulation of cell growth|response to drug|ubiquitin-dependent protein catabolic process	cytoplasm|SCF ubiquitin ligase complex	ubiquitin thiolesterase activity|ubiquitin-specific protease activity|WD40-repeat domain binding			breast(4)|endometrium(7)|kidney(2)|large_intestine(8)|liver(2)|lung(14)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	46				Epithelial(150;0.000339)		CTCCAGTCATAGCAGTGATAC	0.403000													27	91					0	0	1	0	0
ALKBH2	121642	broad.mit.edu	37	12	109530431	109530431	+	Missense_Mutation	SNP	C	C	G			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr12:109530431C>G	ENST00000429722.2	-	2	524	c.161G>C	c.(160-162)gGc>gCc	p.G54A	ALKBH2_ENST00000343075.3_Missense_Mutation_p.G54A|ALKBH2_ENST00000440112.2_Missense_Mutation_p.G54A	NM_001145374.1	NP_001138846.1	Q6NS38	ALKB2_HUMAN	alkB, alkylation repair homolog 2 (E. coli)	54					DNA dealkylation involved in DNA repair|oxidative DNA demethylation	nucleoplasm	cytosine C-5 DNA demethylase activity|damaged DNA binding|DNA-N1-methyladenine dioxygenase activity|ferrous iron binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			endometrium(1)|kidney(3)|large_intestine(1)|lung(3)	8					Vitamin C(DB00126)	CCAGCTAGGGCCTGCTGAGTG	0.567000								Direct reversal of damage					30	114					0	0	1	0	0
THNSL2	55258	broad.mit.edu	37	2	88484880	88484880	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr2:88484880G>T	ENST00000324166.5	+	7	2802	c.1111G>T	c.(1111-1113)Gat>Tat	p.D371Y	THNSL2_ENST00000377254.3_Intron|THNSL2_ENST00000343544.4_Intron|THNSL2_ENST00000402102.1_Intron|THNSL2_ENST00000449349.1_Intron|THNSL2_ENST00000496844.1_Intron|THNSL2_ENST00000358591.2_Missense_Mutation_p.D371Y	NM_018271.4	NP_060741.3	Q86YJ6	THNS2_HUMAN	threonine synthase-like 2 (S. cerevisiae)	371					threonine biosynthetic process		threonine synthase activity			breast(4)|lung(17)|ovary(1)|prostate(3)|upper_aerodigestive_tract(2)	27						GTCAGTGTCGGATGAAGCCAT	0.567000													15	36					2.48551e-13	3.43483e-13	1	1	0
SPPL2C	162540	broad.mit.edu	37	17	43922518	43922518	+	Silent	SNP	C	C	A			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr17:43922518C>A	ENST00000329196.5	+	1	263	c.246C>A	c.(244-246)cgC>cgA	p.R82R	MAPT-AS1_ENST00000579599.1_RNA|MAPT-AS1_ENST00000579244.1_RNA	NM_175882.2	NP_787078.2	Q8IUH8	IMP5_HUMAN	signal peptide peptidase like 2C	82						integral to membrane	aspartic-type endopeptidase activity										CCCAGCTCCGCTCCCCCAGCC	0.692000													9	16					0.00448238	0.0046947	1	1	0
SBK1	388228	broad.mit.edu	37	16	28330438	28330438	+	Missense_Mutation	SNP	G	G	C			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr16:28330438G>C	ENST00000341901.4	+	3	1138	c.349G>C	c.(349-351)Gtc>Ctc	p.V117L		NM_001024401.2	NP_001019572.1	Q52WX2	SBK1_HUMAN	SH3 domain binding kinase 1	117	Protein kinase.					cytoplasm	ATP binding|protein serine/threonine kinase activity			kidney(1)|lung(3)|ovary(1)	5						CTTTGACGTGGTCTTTGAGAC	0.537000													21	80					0	0	1	0	0
KLF12	11278	broad.mit.edu	37	13	74387411	74387411	+	Silent	SNP	G	G	A			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr13:74387411G>A	ENST00000377669.2	-	4	710	c.684C>T	c.(682-684)ccC>ccT	p.P228P	KLF12_ENST00000472022.1_5'UTR|KLF12_ENST00000377666.4_Silent_p.P228P	NM_007249.4	NP_009180.3	Q9Y4X4	KLF12_HUMAN	Kruppel-like factor 12	228					negative regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			central_nervous_system(1)|endometrium(5)|large_intestine(2)|lung(6)|ovary(1)|skin(1)	16		Prostate(6;0.00217)|Breast(118;0.0838)		GBM - Glioblastoma multiforme(99;0.00677)		ATAGGCCTCGGGGGTCCATTT	0.428000													40	83					0	0	1	0	0
KMT2C	58508	broad.mit.edu	37	7	151874411	151874411	+	Silent	SNP	G	G	A			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr7:151874411G>A	ENST00000355193.2	-	38	8345	c.8127C>T	c.(8125-8127)gtC>gtT	p.V2709V	KMT2C_ENST00000262189.6_Silent_p.V2709V					lysine (K)-specific methyltransferase 2C																		CTAAGTCTTTGACTTCAACCC	0.378000													23	72					0	0	1	0	0
PSMD6	9861	broad.mit.edu	37	3	64004295	64004295	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr3:64004295G>A	ENST00000492933.1	-	6	1017	c.965C>T	c.(964-966)tCt>tTt	p.S322F	PSMD6_ENST00000295901.4_Missense_Mutation_p.S269F|PSMD6_ENST00000394431.2_Missense_Mutation_p.S231F|PSMD6_ENST00000482510.1_Missense_Mutation_p.S230F	NM_001271779.1	NP_001258708.1	Q15008	PSMD6_HUMAN	proteasome (prosome, macropain) 26S subunit, non-ATPase, 6	269	PCI.				anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	proteasome complex	ATPase activity|protein binding			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(2)|pancreas(1)|prostate(1)|skin(1)	13		Lung NSC(201;0.136)		BRCA - Breast invasive adenocarcinoma(55;0.000805)|Kidney(15;0.00188)|KIRC - Kidney renal clear cell carcinoma(15;0.00212)		GAAGAAAACAGAGTAACGGCA	0.373000													12	25					0	0	1	0	0
DNAH7	56171	broad.mit.edu	37	2	196689076	196689076	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr2:196689076C>A	ENST00000312428.6	-	49	9294	c.9194G>T	c.(9193-9195)cGg>cTg	p.R3065L		NM_018897.2	NP_061720.2	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	3065	AAA 5 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(4)|breast(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(28)|liver(3)|lung(100)|ovary(4)|prostate(5)|skin(26)|upper_aerodigestive_tract(2)|urinary_tract(3)	205						GTCCCCAAGCCGGATACATGT	0.413000													25	83					3.96558e-24	6.2631e-24	1	1	0
IL31RA	133396	broad.mit.edu	37	5	55164699	55164699	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr5:55164699G>A	ENST00000396834.1	+	5	674	c.178G>A	c.(178-180)Gaa>Aaa	p.E60K	IL31RA_ENST00000359040.5_Missense_Mutation_p.E79K|IL31RA_ENST00000447346.2_Missense_Mutation_p.E79K|IL31RA_ENST00000297015.3_Intron|IL31RA_ENST00000396836.2_Missense_Mutation_p.E79K|IL31RA_ENST00000354961.4_Missense_Mutation_p.E60K|IL31RA_ENST00000490985.1_5'UTR	NM_001242638.1	NP_001229567.1	Q8NI17	IL31R_HUMAN	interleukin 31 receptor A	47	Fibronectin type-III 1.				anti-apoptosis|defense response|homeostatic process|JAK-STAT cascade|macrophage differentiation|MAPKKK cascade|monocyte differentiation|negative regulation of macrophage activation|positive regulation of cell proliferation|positive regulation of transcription, DNA-dependent|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of tyrosine phosphorylation of Stat5 protein|transmembrane receptor protein tyrosine kinase signaling pathway	integral to membrane|plasma membrane	cytokine receptor activity|protein kinase binding|transcription coactivator activity			endometrium(2)|kidney(2)|large_intestine(7)|lung(8)|ovary(1)|stomach(1)	21		Lung NSC(810;6.93e-05)|Prostate(74;0.00741)|Breast(144;0.0544)|Ovarian(174;0.223)				TCCAGGAAAGGAAACCAGTTA	0.418000													41	124					0	0	1	0	0
UGT2B4	7363	broad.mit.edu	37	4	70351130	70351130	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr4:70351130C>A	ENST00000305107.6	-	5	1152	c.1106G>T	c.(1105-1107)aGa>aTa	p.R369I	UGT2B4_ENST00000506580.1_Intron|UGT2B4_ENST00000381096.3_Missense_Mutation_p.R233I|UGT2B4_ENST00000512583.1_Intron	NM_021139.2	NP_066962.2	P06133	UD2B4_HUMAN	UDP glucuronosyltransferase 2 family, polypeptide B4	369					estrogen catabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(29)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	47						TATAAAAGCTCTGGTTTTTGG	0.398000													50	155					2.55665e-31	4.2754e-31	1	1	0
SMU1	55234	broad.mit.edu	37	9	33068870	33068870	+	Silent	SNP	G	G	A	rs113018466	byFrequency	TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr9:33068870G>A	ENST00000397149.3	-	4	503	c.453C>T	c.(451-453)ggC>ggT	p.G151G	SMU1_ENST00000536631.1_5'UTR	NM_018225.2	NP_060695.2	Q2TAY7	SMU1_HUMAN	smu-1 suppressor of mec-8 and unc-52 homolog (C. elegans)	151						cytoplasm|nucleus				endometrium(2)|lung(4)|ovary(2)|prostate(1)	9			LUSC - Lung squamous cell carcinoma(29;0.0227)	GBM - Glioblastoma multiforme(74;0.11)		CACTGACTTCGCCAGCTAAGG	0.507000													3	53					0	0	1	0	0
MAZ	4150	broad.mit.edu	37	16	29821464	29821464	+	Missense_Mutation	SNP	T	T	C			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr16:29821464T>C	ENST00000322945.6	+	5	1511	c.1346T>C	c.(1345-1347)gTa>gCa	p.V449A	MAZ_ENST00000568282.1_3'UTR|MAZ_ENST00000545521.1_Missense_Mutation_p.V426A|AC009133.14_ENST00000569981.1_RNA|MAZ_ENST00000219782.6_3'UTR|MAZ_ENST00000568544.1_Missense_Mutation_p.V50A|AC009133.20_ENST00000569039.1_RNA|MAZ_ENST00000563402.1_Silent_p.S105S|MAZ_ENST00000562337.1_Missense_Mutation_p.V144A|MAZ_ENST00000566906.2_Silent_p.S103S	NM_002383.2	NP_002374.2	P56270	MAZ_HUMAN	MYC-associated zinc finger protein (purine-binding transcription factor)	449	Poly-Ala.				regulation of transcription, DNA-dependent|termination of RNA polymerase II transcription|transcription initiation from RNA polymerase II promoter	nucleus	DNA binding|protein binding|RNA binding|zinc ion binding			endometrium(3)|lung(4)|ovary(2)|upper_aerodigestive_tract(1)	10						gcggcagcagtagcagcCCCT	0.672000													6	13					0	0	1	0	0
XIRP2	129446	broad.mit.edu	37	2	168100016	168100016	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr2:168100016G>T	ENST00000409195.1	+	9	2203	c.2114G>T	c.(2113-2115)gGa>gTa	p.G705V	XIRP2_ENST00000409043.1_Intron|XIRP2_ENST00000420519.1_Intron|XIRP2_ENST00000409756.2_Intron|XIRP2_ENST00000409728.1_Intron|XIRP2_ENST00000409605.1_Intron|XIRP2_ENST00000409273.1_Missense_Mutation_p.G483V|XIRP2_ENST00000295237.9_Missense_Mutation_p.G705V	NM_152381.5	NP_689594.4	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2	530					actin cytoskeleton organization	cell junction	actin binding			NS(3)|biliary_tract(2)|breast(5)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(51)|lung(160)|ovary(7)|pancreas(3)|prostate(11)|skin(14)|stomach(5)|upper_aerodigestive_tract(8)|urinary_tract(7)	315						GATCAACTTGGACAGCTTCAT	0.383000													18	52					1.55795e-14	2.23044e-14	1	1	0
FAM171A1	221061	broad.mit.edu	37	10	15263031	15263031	+	Silent	SNP	A	A	T			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr10:15263031A>T	ENST00000378116.4	-	6	789	c.783T>A	c.(781-783)ctT>ctA	p.L261L	FAM171A1_ENST00000477161.1_5'UTR	NM_001010924.1	NP_001010924.1	Q5VUB5	F1711_HUMAN	family with sequence similarity 171, member A1	261						integral to membrane				breast(6)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(20)|ovary(3)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	52						CCTGGTGCACAAGACCCAGAC	0.552000													32	63					0	0	1	0	0
ATP10B	23120	broad.mit.edu	37	5	160049472	160049472	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr5:160049472C>A	ENST00000327245.5	-	14	2587	c.1741G>T	c.(1741-1743)Gct>Tct	p.A581S	CTC-348L5.1_ENST00000523598.1_RNA	NM_025153.2	NP_079429.2	O94823	AT10B_HUMAN	ATPase, class V, type 10B	581					ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			NS(2)|autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|liver(2)|lung(37)|ovary(4)|pancreas(1)|prostate(5)|skin(3)|stomach(1)	75	Renal(175;0.00196)	Medulloblastoma(196;0.0377)|all_neural(177;0.121)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			AAGAAATCAGCAATGGAGGAG	0.557000													30	25					3.99451e-17	5.8882e-17	1	1	0
LOC101927209	101927209	broad.mit.edu	37	1	142713774	142713774	+	RNA	SNP	A	A	G			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr1:142713774A>G	ENST00000369381.2	-	0	831																											CTTTTTCCACATTGTCATTTT	0.284000													4	74					0	0	1	0	0
IFNA8	3445	broad.mit.edu	37	9	21409660	21409660	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr9:21409660G>A	ENST00000380205.1	+	1	515	c.485G>A	c.(484-486)tGt>tAt	p.C162Y		NM_002170.3	NP_002161.2	P32881	IFNA8_HUMAN	interferon, alpha 8	162					blood coagulation|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	extracellular space	cytokine activity|cytokine receptor binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(5)|ovary(1)	9				Lung(24;7.66e-27)|LUSC - Lung squamous cell carcinoma(38;1.4e-13)|OV - Ovarian serous cystadenocarcinoma(39;0.0174)		TACAGCTCTTGTGCCTGGGAG	0.428000													76	232					0	0	1	0	0
TACC2	10579	broad.mit.edu	37	10	123997538	123997538	+	Missense_Mutation	SNP	A	A	T			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr10:123997538A>T	ENST00000369005.1	+	18	8674	c.8334A>T	c.(8332-8334)gaA>gaT	p.E2778D	TACC2_ENST00000334433.3_Missense_Mutation_p.E2778D|TACC2_ENST00000358010.1_Missense_Mutation_p.E924D|TACC2_ENST00000369004.3_Missense_Mutation_p.E838D|TACC2_ENST00000369001.1_Missense_Mutation_p.E405D|TACC2_ENST00000513429.1_Missense_Mutation_p.E924D|TACC2_ENST00000368999.1_Missense_Mutation_p.E868D|TACC2_ENST00000369000.1_Missense_Mutation_p.E401D|TACC2_ENST00000360561.3_Missense_Mutation_p.E826D|TACC2_ENST00000515273.1_Missense_Mutation_p.E2705D|TACC2_ENST00000453444.2_Missense_Mutation_p.E2705D|TACC2_ENST00000260733.3_Missense_Mutation_p.E856D|TACC2_ENST00000515603.1_Missense_Mutation_p.E2656D	NM_206862.2	NP_996744.2	O95359	TACC2_HUMAN	transforming, acidic coiled-coil containing protein 2	2778						microtubule organizing center|nucleus	nuclear hormone receptor binding			NS(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(15)|lung(27)|ovary(6)|prostate(3)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	83		all_neural(114;0.0656)|Lung NSC(174;0.136)|all_lung(145;0.17)|Breast(234;0.197)				GCAGGCGGGAAGTGATGGAAA	0.473000													9	25					0	0	1	0	0
MTOR	2475	broad.mit.edu	37	1	11270918	11270918	+	Nonsense_Mutation	SNP	G	G	A			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr1:11270918G>A	ENST00000361445.4	-	24	3683	c.3607C>T	c.(3607-3609)Cga>Tga	p.R1203*		NM_004958.3	NP_004949.1	P42345	MTOR_HUMAN	mechanistic target of rapamycin (serine/threonine kinase)	1203					cell growth|cellular response to hypoxia|insulin receptor signaling pathway|nerve growth factor receptor signaling pathway|peptidyl-serine phosphorylation|phosphatidylinositol-mediated signaling|protein autophosphorylation|protein catabolic process|response to amino acid stimulus|response to nutrient|T cell costimulation|TOR signaling cascade	endoplasmic reticulum membrane|Golgi membrane|lysosome|mitochondrial outer membrane|phosphatidylinositol 3-kinase complex|PML body|TORC1 complex|TORC2 complex	ATP binding|phosphoprotein binding|protein serine/threonine kinase activity			breast(5)|central_nervous_system(7)|endometrium(20)|kidney(34)|large_intestine(21)|lung(43)|ovary(9)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	149						TGATTGATTCGGTGTCGCACC	0.393000													5	75					0	0	1	0	0
VWA3A	146177	broad.mit.edu	37	16	22163834	22163834	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr16:22163834C>A	ENST00000389397.4	+	32	3452	c.590C>A	c.(589-591)gCg>gAg	p.A197E	VWA3A_ENST00000563755.1_Missense_Mutation_p.A197E|VWA3A_ENST00000389398.5_Missense_Mutation_p.A1095E			A6NCI4	VWA3A_HUMAN	von Willebrand factor A domain containing 3A	1095						extracellular region				haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(1)|skin(1)	7				GBM - Glioblastoma multiforme(48;0.0439)		CCTTCCAGAGCGGCGGTTGAG	0.587000													7	15					0.000274275	0.000299894	1	1	0
MORC3	23515	broad.mit.edu	37	21	37741631	37741631	+	Silent	SNP	T	T	A			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr21:37741631T>A	ENST00000400485.1	+	15	2041	c.1965T>A	c.(1963-1965)gtT>gtA	p.V655V	MORC3_ENST00000487909.1_3'UTR	NM_015358.2	NP_056173.1	Q14149	MORC3_HUMAN	MORC family CW-type zinc finger 3	655					cell aging|maintenance of protein location in nucleus|negative regulation of fibroblast proliferation|peptidyl-serine phosphorylation|protein stabilization	aggresome|intermediate filament cytoskeleton|PML body	ATP binding|zinc ion binding			breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(7)|lung(9)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	35						AAGAAACTGTTGAAGACGAGA	0.438000													24	73					0	0	1	0	0
ABRA	137735	broad.mit.edu	37	8	107773518	107773518	+	Missense_Mutation	SNP	C	C	G			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr8:107773518C>G	ENST00000311955.3	-	2	947	c.893G>C	c.(892-894)aGg>aCg	p.R298T		NM_139166.4	NP_631905.1	Q8N0Z2	ABRA_HUMAN	actin-binding Rho activating protein	298					positive regulation of Rho protein signal transduction|positive regulation of sequence-specific DNA binding transcription factor activity|transcription, DNA-dependent|transmembrane transport	actin cytoskeleton|plasma membrane|sarcomere	actin binding			breast(1)|kidney(4)|large_intestine(7)|lung(11)|ovary(2)|prostate(2)	27			OV - Ovarian serous cystadenocarcinoma(57;3.83e-09)			ACGCTTGGCCCTTTCAGCAGT	0.517000													16	43					0	0	1	0	0
STAB2	55576	broad.mit.edu	37	12	104077048	104077048	+	Nonsense_Mutation	SNP	C	C	A			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr12:104077048C>A	ENST00000388887.2	+	26	3075	c.2871C>A	c.(2869-2871)tgC>tgA	p.C957*		NM_017564.9	NP_060034.9	Q8WWQ8	STAB2_HUMAN	stabilin 2	957	EGF-like 10.				angiogenesis|cell adhesion|defense response to bacterium|receptor-mediated endocytosis	cytoplasm|external side of plasma membrane|integral to plasma membrane	Gram-negative bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			NS(4)|breast(7)|central_nervous_system(1)|cervix(1)|endometrium(15)|kidney(11)|large_intestine(26)|lung(77)|ovary(10)|pancreas(1)|prostate(5)|skin(14)|stomach(2)	174						TAACTTCATGCTTGGAACAAA	0.323000													26	62					1.30897e-18	1.97337e-18	1	1	0
C1orf64	149563	broad.mit.edu	37	1	16330828	16330828	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr1:16330828G>T	ENST00000329454.2	+	1	98	c.30G>T	c.(28-30)tgG>tgT	p.W10C		NM_178840.2	NP_849162.1	Q8NEQ6	CA064_HUMAN	chromosome 1 open reading frame 64	10										breast(2)|endometrium(1)|lung(3)	6		Colorectal(325;0.000435)|Renal(390;0.00145)|Breast(348;0.00224)|Lung NSC(340;0.00566)|all_lung(284;0.00831)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.104)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Colorectal(212;3.25e-07)|COAD - Colon adenocarcinoma(227;2.08e-05)|BRCA - Breast invasive adenocarcinoma(304;9.19e-05)|Kidney(64;0.000165)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(313;0.0114)|READ - Rectum adenocarcinoma(331;0.0649)		CCAGGGACTGGAGAGCCAACC	0.642000													4	8					0.00024832	0.000273015	1	1	0
HNRNPD	3184	broad.mit.edu	37	4	83279893	83279893	+	Silent	SNP	C	C	A			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr4:83279893C>A	ENST00000313899.7	-	4	817	c.540G>T	c.(538-540)ccG>ccT	p.P180P	HNRNPD_ENST00000543098.1_Silent_p.P128P|HNRNPD_ENST00000541060.1_Silent_p.P26P|HNRNPD_ENST00000352301.4_Silent_p.P161P|HNRNPD_ENST00000353341.4_Silent_p.P180P	NM_031370.2	NP_112738.1	Q14103	HNRPD_HUMAN	heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)	180					nuclear mRNA splicing, via spliceosome|positive regulation of transcription, DNA-dependent|RNA catabolic process|transcription, DNA-dependent	cytosol|heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	nucleotide binding|protein binding|RNA binding|telomeric DNA binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(1)	7						TTTTTTTAACCGGCTCTTTTG	0.363000													26	57					9.90768e-06	1.13967e-05	1	1	0
TET1	80312	broad.mit.edu	37	10	70360780	70360780	+	Missense_Mutation	SNP	A	A	G			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr10:70360780A>G	ENST00000373644.4	+	3	2166	c.1957A>G	c.(1957-1959)Aaa>Gaa	p.K653E		NM_030625.2	NP_085128.2	Q8NFU7	TET1_HUMAN	tet methylcytosine dioxygenase 1	653	Sufficient for binding to genomic CpG islands.				DNA demethylation|inner cell mass cell differentiation|negative regulation of methylation-dependent chromatin silencing|stem cell maintenance		iron ion binding|methylcytosine dioxygenase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|structure-specific DNA binding|zinc ion binding			breast(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(2)|ovary(5)|prostate(1)|upper_aerodigestive_tract(2)	21						AAAGAAGCCCAAAGTTTTAAA	0.308000													18	61					0	0	1	0	0
TGM7	116179	broad.mit.edu	37	15	43577088	43577088	+	Missense_Mutation	SNP	C	C	G			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr15:43577088C>G	ENST00000452443.2	-	7	932	c.928G>C	c.(928-930)Gat>Cat	p.D310H		NM_052955.2	NP_443187.1	Q96PF1	TGM7_HUMAN	transglutaminase 7	310					peptide cross-linking		acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(3)|large_intestine(8)|lung(16)|ovary(2)|prostate(4)|skin(1)	39		all_cancers(109;2.12e-14)|all_epithelial(112;1.99e-12)|Lung NSC(122;2.46e-08)|all_lung(180;2.75e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;9.14e-07)	L-Glutamine(DB00130)	AAGTTCCTATCCACGTTGTGC	0.433000													33	103					0	0	1	0	0
CLCN1	1180	broad.mit.edu	37	7	143043333	143043333	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr7:143043333C>A	ENST00000343257.2	+	18	2360	c.2273C>A	c.(2272-2274)cCa>cAa	p.P758Q		NM_000083.2	NP_000074.2	P35523	CLCN1_HUMAN	chloride channel, voltage-sensitive 1	758					muscle contraction	chloride channel complex|integral to plasma membrane	voltage-gated chloride channel activity			breast(4)|central_nervous_system(1)|endometrium(1)|large_intestine(11)|lung(26)|ovary(3)|prostate(2)|skin(7)|stomach(1)|upper_aerodigestive_tract(2)	58	Melanoma(164;0.205)					CCGGAAGCACCAGAGCCTGCA	0.592000													13	40					0.00010058	0.000111197	1	1	0
PNLIPRP3	119548	broad.mit.edu	37	10	118203905	118203905	+	Silent	SNP	G	G	A			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr10:118203905G>A	ENST00000369230.3	+	4	482	c.336G>A	c.(334-336)caG>caA	p.Q112Q		NM_001011709.2	NP_001011709.2	Q17RR3	LIPR3_HUMAN	pancreatic lipase-related protein 3	112					lipid catabolic process	extracellular region	triglyceride lipase activity			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(9)|lung(29)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	50				all cancers(201;0.0131)		TGTTGCTACAGCTGGAAGATA	0.358000													9	38					0	0	1	0	0
SYNPR	132204	broad.mit.edu	37	3	63429126	63429126	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr3:63429126G>T	ENST00000295894.5	+	1	374	c.5G>T	c.(4-6)tGt>tTt	p.C2F	SYNPR_ENST00000478744.1_3'UTR|SYNPR-AS1_ENST00000488201.1_RNA|SYNPR_ENST00000465156.1_Missense_Mutation_p.C2F|SYNPR_ENST00000460711.1_Missense_Mutation_p.C2F|SYNPR_ENST00000479198.1_Missense_Mutation_p.C2F|SYNPR_ENST00000478300.1_Intron	NM_144642.4	NP_653243.1	Q8TBG9	SYNPR_HUMAN	synaptoporin	2	MARVEL.					cell junction|integral to membrane|synaptic vesicle membrane|synaptosome	transporter activity			NS(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(3)	8				BRCA - Breast invasive adenocarcinoma(55;0.000918)|KIRC - Kidney renal clear cell carcinoma(15;0.0658)|Kidney(15;0.0904)		TTGTAAATGTGTATGGTGATA	0.403000													6	11					2.0095e-06	2.36621e-06	1	1	0
PTH2	113091	broad.mit.edu	37	19	49925835	49925835	+	Silent	SNP	G	G	A			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr19:49925835G>A	ENST00000270631.1	-	2	294	c.193C>T	c.(193-195)Ctg>Ttg	p.L65L		NM_178449.3	NP_848544.1	Q96A98	TIP39_HUMAN	parathyroid hormone 2	65					neuropeptide signaling pathway	extracellular region				endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|skin(1)	6				OV - Ovarian serous cystadenocarcinoma(262;0.0015)|GBM - Glioblastoma multiforme(486;0.044)|Lung(386;0.0785)|LUSC - Lung squamous cell carcinoma(496;0.0836)		TCGTCCGCCAGCGCCAGGCTC	0.741000													6	10					0	0	1	0	0
HHIPL1	84439	broad.mit.edu	37	14	100118894	100118894	+	Missense_Mutation	SNP	G	G	A	rs145984890		TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr14:100118894G>A	ENST00000330710.5	+	2	687	c.589G>A	c.(589-591)Gtg>Atg	p.V197M	HHIPL1_ENST00000357223.2_Missense_Mutation_p.V197M	NM_001127258.1	NP_001120730.1	Q96JK4	HIPL1_HUMAN	HHIP-like 1	197					carbohydrate metabolic process	extracellular region|membrane	oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor|quinone binding|scavenger receptor activity			breast(1)|endometrium(2)|large_intestine(2)|lung(8)|skin(2)	15		Melanoma(154;0.128)				GCGCAACCCCGTGGCCATGGT	0.667000													3	36					0	0	1	0	0
OR8U1	219417	broad.mit.edu	37	11	56143640	56143640	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr11:56143640G>T	ENST00000302270.1	+	1	541	c.541G>T	c.(541-543)Gac>Tac	p.D181Y		NM_001005204.1	NP_001005204.1			olfactory receptor, family 8, subfamily U, member 1											NS(1)|breast(2)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(1)|lung(23)|ovary(4)|skin(1)|stomach(1)	39	Esophageal squamous(21;0.00448)					CTATTGTGATGACATGCCTCT	0.458000													55	213					1.14385e-22	1.77834e-22	1	1	0
LRRC17	10234	broad.mit.edu	37	7	102574765	102574765	+	Missense_Mutation	SNP	A	A	T			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr7:102574765A>T	ENST00000249377.4	+	2	686	c.405A>T	c.(403-405)ttA>ttT	p.L135F	LRRC17_ENST00000339431.4_Missense_Mutation_p.L135F|FBXL13_ENST00000379308.3_Intron|FBXL13_ENST00000455112.2_Intron|FBXL13_ENST00000456695.1_Intron|FBXL13_ENST00000436908.1_Intron|FBXL13_ENST00000379305.3_Intron|FBXL13_ENST00000313221.4_Intron|FBXL13_ENST00000393772.2_Intron|FBXL13_ENST00000379306.3_Intron	NM_005824.2	NP_005815.2	Q8N6Y2	LRC17_HUMAN	leucine rich repeat containing 17	135					bone marrow development|negative regulation of osteoclast differentiation|ossification	extracellular space				NS(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(5)|liver(2)|lung(3)|ovary(1)|prostate(1)|urinary_tract(1)	17						CCACCCTCTTACTGCAGCACA	0.443000													16	49					0	0	1	0	0
CCDC51	79714	broad.mit.edu	37	3	48473961	48473961	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr3:48473961C>A	ENST00000395694.2	-	4	1178	c.1093G>T	c.(1093-1095)Ggg>Tgg	p.G365W	CCDC51_ENST00000395696.1_Missense_Mutation_p.G365W|CCDC51_ENST00000412398.2_Missense_Mutation_p.G256W|CCDC51_ENST00000447018.1_Missense_Mutation_p.G256W|CCDC51_ENST00000442740.1_Missense_Mutation_p.G256W	NM_001256964.1	NP_001243893.1	Q96ER9	CCD51_HUMAN	coiled-coil domain containing 51	365						integral to membrane				endometrium(4)|kidney(4)|large_intestine(1)|lung(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	15				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00551)|Kidney(197;0.00621)		ATCATGCTCCCCTGCTCCAGC	0.552000													3	51					1	1	1	1	0
PPP1R15A	23645	broad.mit.edu	37	19	49377008	49377008	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr19:49377008G>A	ENST00000200453.5	+	2	787	c.518G>A	c.(517-519)gGa>gAa	p.G173E		NM_014330.3	NP_055145.3	O75807	PR15A_HUMAN	protein phosphatase 1, regulatory subunit 15A	173	Glu-rich.|Required for localization in the endoplasmic reticulum.				apoptosis|cell cycle arrest|regulation of translation|response to DNA damage stimulus	endoplasmic reticulum	protein binding			breast(1)|endometrium(4)|kidney(1)|large_intestine(6)|lung(8)|skin(2)|urinary_tract(1)	23		all_epithelial(76;5.29e-07)|all_lung(116;1.7e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.000244)|all cancers(93;0.000694)|GBM - Glioblastoma multiforme(486;0.0222)|Epithelial(262;0.033)		GAAGAGGAGGGAGTTAACAAG	0.527000													16	45					0	0	1	0	0
SLC45A2	51151	broad.mit.edu	37	5	33951714	33951714	+	Silent	SNP	G	G	T			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr5:33951714G>T	ENST00000382102.3	-	5	1158	c.1101C>A	c.(1099-1101)gtC>gtA	p.V367V	SLC45A2_ENST00000296589.4_Silent_p.V367V|SLC45A2_ENST00000342059.3_Silent_p.V308V|SLC45A2_ENST00000345083.5_Silent_p.V259V|SLC45A2_ENST00000509381.1_3'UTR	NM_001012509.2	NP_001012527.1	Q9UMX9	S45A2_HUMAN	solute carrier family 45, member 2	367					melanin biosynthetic process|response to stimulus|transmembrane transport|visual perception	integral to membrane|melanosome membrane				breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(25)|ovary(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	48						ATCCAACCTCGACTCCTCTTT	0.453000													63	111					3.00063e-23	4.70177e-23	1	1	0
COL1A2	1278	broad.mit.edu	37	7	94053727	94053727	+	Missense_Mutation	SNP	G	G	A	rs140368271		TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr7:94053727G>A	ENST00000297268.6	+	41	3116	c.2645G>A	c.(2644-2646)cGt>cAt	p.R882H		NM_000089.3	NP_000080.2	P08123	CO1A2_HUMAN	collagen, type I, alpha 2	882					axon guidance|blood vessel development|collagen fibril organization|leukocyte migration|odontogenesis|platelet activation|regulation of blood pressure|Rho protein signal transduction|skeletal system development|skin morphogenesis|transforming growth factor beta receptor signaling pathway	collagen type I|extracellular space|plasma membrane	extracellular matrix structural constituent|identical protein binding|platelet-derived growth factor binding|protein binding, bridging		COL1A2/PLAG1(3)	NS(2)|breast(2)|central_nervous_system(4)|cervix(1)|endometrium(6)|kidney(8)|large_intestine(21)|lung(51)|ovary(2)|prostate(1)|skin(7)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(1)	115	all_cancers(62;2.46e-09)|all_epithelial(64;2.7e-08)		STAD - Stomach adenocarcinoma(171;0.0031)		Collagenase(DB00048)	AGAGGTGAACGTGGTCTACCA	0.478000										HNSCC(75;0.22)			29	89					0	0	1	0	0
TCF7L1	83439	broad.mit.edu	37	2	85532493	85532493	+	Missense_Mutation	SNP	C	C	A	rs138614113	byFrequency	TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr2:85532493C>A	ENST00000282111.3	+	8	1231	c.956C>A	c.(955-957)cCg>cAg	p.P319Q		NM_031283.2	NP_112573.1	Q9HCS4	TF7L1_HUMAN	transcription factor 7-like 1 (T-cell specific, HMG-box)	319	Pro-rich.				chromatin organization|regulation of Wnt receptor signaling pathway|Wnt receptor signaling pathway	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(3)|skin(4)|upper_aerodigestive_tract(1)	18						AAGCAGGAACCGGCACCCCCC	0.662000													3	57					1	1	1	1	0
LLGL1	3996	broad.mit.edu	37	17	18135839	18135839	+	Silent	SNP	C	C	T			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr17:18135839C>T	ENST00000316843.4	+	3	306	c.210C>T	c.(208-210)ggC>ggT	p.G70G		NM_004140.3	NP_004131.3	Q15334	L2GL1_HUMAN	lethal giant larvae homolog 1 (Drosophila)	70					cortical actin cytoskeleton organization|exocytosis|protein complex assembly	cortical actin cytoskeleton	protein kinase binding|structural molecule activity			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(6)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	21	all_neural(463;0.228)					AGTTCACAGGCCTGCACCGGG	0.587000													6	20					0	0	1	0	0
AKAP17A	8227	broad.mit.edu	37	X	1714286	1714286	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chrX:1714286G>T	ENST00000313871.3	+	3	968	c.772G>T	c.(772-774)Gat>Tat	p.D258Y	AKAP17A_ENST00000381261.3_Missense_Mutation_p.D258Y	NM_005088.2	NP_005079.2	Q02040	AK17A_HUMAN	A kinase (PRKA) anchor protein 17A	258					B cell activation|mRNA processing|regulation of transcription, DNA-dependent|RNA splicing|signal transduction	nuclear speck|spliceosomal complex	nucleotide binding|protein binding|RNA binding			breast(2)|endometrium(5)|kidney(3)|large_intestine(1)|lung(12)|prostate(3)	26						GGTTTCTTTTGATTCGACCAA	0.537000													61	87					1.40369e-38	2.38747e-38	1	1	0
STARD13	90627	broad.mit.edu	37	13	33701594	33701594	+	Missense_Mutation	SNP	A	A	T			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr13:33701594A>T	ENST00000336934.5	-	6	1954	c.1838T>A	c.(1837-1839)cTg>cAg	p.L613Q	STARD13_ENST00000399365.3_Missense_Mutation_p.L495Q|STARD13_ENST00000255486.4_Missense_Mutation_p.L605Q	NM_001243476.1|NM_178006.3	NP_001230405.1|NP_821074.1	Q9Y3M8	STA13_HUMAN	StAR-related lipid transfer (START) domain containing 13	613					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|lipid particle|mitochondrial membrane	GTPase activator activity|protein binding			breast(2)|endometrium(2)|kidney(3)|large_intestine(6)|lung(18)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|soft_tissue(1)|upper_aerodigestive_tract(1)	40	all_epithelial(80;0.155)	Lung SC(185;0.0367)		all cancers(112;1.31e-05)|Epithelial(112;0.000142)|BRCA - Breast invasive adenocarcinoma(63;0.00936)|OV - Ovarian serous cystadenocarcinoma(117;0.0533)|Lung(94;0.143)|GBM - Glioblastoma multiforme(144;0.143)		GAGCAGGCTCAGCTGGCTGGC	0.627000													10	16					0	0	1	0	0
HKDC1	80201	broad.mit.edu	37	10	71026382	71026382	+	Nonsense_Mutation	SNP	C	C	T			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr10:71026382C>T	ENST00000354624.5	+	18	2756	c.2623C>T	c.(2623-2625)Cag>Tag	p.Q875*	RP11-227H15.5_ENST00000413220.1_RNA	NM_025130.3	NP_079406.3	Q2TB90	HKDC1_HUMAN	hexokinase domain containing 1	875					glycolysis	mitochondrion|nucleus	ATP binding|hexokinase activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(11)|ovary(5)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	34						TAGAATATTGCAGGAAACTGT	0.403000													26	88					0	0	1	0	0
OR51S1	119692	broad.mit.edu	37	11	4869599	4869599	+	Silent	SNP	A	A	G			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr11:4869599A>G	ENST00000322101.2	-	1	915	c.840T>C	c.(838-840)caT>caC	p.H280H	MMP26_ENST00000380390.1_Intron|MMP26_ENST00000477339.1_Intron	NM_001004758.1	NP_001004758.1	Q8NGJ8	O51S1_HUMAN	olfactory receptor, family 51, subfamily S, member 1	280					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(3)|lung(15)|ovary(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	33		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;5.06e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00438)|LUSC - Lung squamous cell carcinoma(625;0.19)		ATAGAAGAGTATGGGTATGCT	0.448000													34	87					0	0	1	0	0
ABCC11	85320	broad.mit.edu	37	16	48234284	48234284	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr16:48234284G>A	ENST00000394747.1	-	14	2334	c.1985C>T	c.(1984-1986)tCt>tTt	p.S662F	ABCC11_ENST00000537808.1_Missense_Mutation_p.S662F|ABCC11_ENST00000394748.1_Missense_Mutation_p.S662F|ABCC11_ENST00000353782.5_Missense_Mutation_p.S662F|ABCC11_ENST00000356608.2_Missense_Mutation_p.S662F	NM_033151.3	NP_149163.2	Q96J66	ABCCB_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 11	662	ABC transporter 1.					integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(3)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(42)|ovary(3)|prostate(2)|skin(5)|urinary_tract(2)	83		all_cancers(37;0.127)|all_lung(18;0.132)|Breast(268;0.166)				GTCCACAGCAGACAGGGGGTC	0.612000													17	57					0	0	1	0	0
STAB1	23166	broad.mit.edu	37	3	52544224	52544224	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr3:52544224C>A	ENST00000321725.6	+	24	2677	c.2601C>A	c.(2599-2601)caC>caA	p.H867Q		NM_015136.2	NP_055951.2	Q9NY15	STAB1_HUMAN	stabilin 1	867	EGF-like 7.				cell adhesion|cell-cell signaling|defense response to bacterium|inflammatory response|negative regulation of angiogenesis|receptor-mediated endocytosis	integral to plasma membrane	bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			breast(4)|central_nervous_system(3)|endometrium(7)|kidney(2)|large_intestine(13)|liver(1)|lung(27)|ovary(1)|pancreas(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(3)	76				BRCA - Breast invasive adenocarcinoma(193;1.73e-05)|Kidney(197;0.00182)|KIRC - Kidney renal clear cell carcinoma(197;0.00205)|OV - Ovarian serous cystadenocarcinoma(275;0.0482)		CCTGCTCCCACCCGGACCGTG	0.622000													18	79					0.006122	0.00637842	1	1	0
POF1B	79983	broad.mit.edu	37	X	84585975	84585975	+	Missense_Mutation	SNP	A	A	T			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chrX:84585975A>T	ENST00000262753.4	-	7	979	c.834T>A	c.(832-834)caT>caA	p.H278Q	POF1B_ENST00000373145.3_Missense_Mutation_p.H278Q	NM_024921.3	NP_079197.3	Q8WVV4	POF1B_HUMAN	premature ovarian failure, 1B	278							actin binding			central_nervous_system(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(3)|liver(2)|lung(17)|ovary(1)|prostate(1)	35						TTCTCTGCAAATGTTCTAATA	0.368000													15	11					0	0	1	0	0
UCK2	7371	broad.mit.edu	37	1	165872437	165872437	+	Missense_Mutation	SNP	A	A	T			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr1:165872437A>T	ENST00000367879.4	+	5	821	c.518A>T	c.(517-519)gAg>gTg	p.E173V	UCK2_ENST00000372212.4_Silent_p.R125R|UCK2_ENST00000479872.1_3'UTR	NM_012474.4	NP_036606.2	Q9BZX2	UCK2_HUMAN	uridine-cytidine kinase 2	173					pyrimidine base metabolic process|pyrimidine nucleoside salvage	cytosol	ATP binding|phosphotransferase activity, alcohol group as acceptor|uridine kinase activity			breast(1)|endometrium(2)|large_intestine(2)|lung(3)|ovary(1)|upper_aerodigestive_tract(1)	10	all_hematologic(923;0.048)|Acute lymphoblastic leukemia(8;0.155)					GACATCAGCGAGAGAGGCAGG	0.483000													7	150					0	0	1	0	0
ASTN2	23245	broad.mit.edu	37	9	119976989	119976989	+	Silent	SNP	C	C	A			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr9:119976989C>A	ENST00000313400.4	-	3	763	c.663G>T	c.(661-663)ctG>ctT	p.L221L	ASTN2_ENST00000373996.3_Silent_p.L221L|ASTN2_ENST00000361477.3_5'UTR|ASTN2_ENST00000361209.2_Silent_p.L221L			O75129	ASTN2_HUMAN	astrotactin 2	221						integral to membrane				breast(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(21)|lung(45)|ovary(4)|pancreas(2)|prostate(2)|skin(9)|stomach(1)|urinary_tract(1)	102						CGGTGAACACCAGCAGCAGCA	0.597000													16	31					6.94344e-10	8.80092e-10	1	1	0
CCDC136	64753	broad.mit.edu	37	7	128441511	128441511	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr7:128441511G>T	ENST00000297788.4	+	4	985	c.618G>T	c.(616-618)aaG>aaT	p.K206N	CCDC136_ENST00000378685.4_Missense_Mutation_p.K256N|CCDC136_ENST00000464832.1_Missense_Mutation_p.K256N|CCDC136_ENST00000487361.1_Missense_Mutation_p.K206N	NM_022742.4	NP_073579.4	Q96JN2	CC136_HUMAN	coiled-coil domain containing 136	206	Glu-rich.					integral to membrane	protein binding			breast(2)|endometrium(3)|kidney(1)|large_intestine(4)|lung(11)|ovary(3)	24						TGGAAATGAAGAGCTCTGAAC	0.483000													4	20					0.000602214	0.000654867	1	1	0
CBX5	23468	broad.mit.edu	37	12	54645824	54645824	+	Splice_Site	SNP	C	C	T			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr12:54645824C>T	ENST00000209875.4	-	3	461		c.e3+1		CBX5_ENST00000439541.2_Splice_Site|CBX5_ENST00000550411.1_Splice_Site	NM_012117.2	NP_036249.1	P45973	CBX5_HUMAN	chromobox homolog 5						blood coagulation|interspecies interaction between organisms|negative regulation of transcription, DNA-dependent	cytoplasm|histone deacetylase complex|histone methyltransferase complex|nuclear centromeric heterochromatin|nuclear envelope|nucleolus|transcriptional repressor complex	methylated histone residue binding|protein binding, bridging|repressing transcription factor binding			endometrium(1)|kidney(1)|large_intestine(2)|lung(1)|prostate(1)|skin(2)	8						AGGAAGCTTACCTCTCTCTTT	0.323000													26	131					0	0	1	0	0
MICAL3	57553	broad.mit.edu	37	22	18300822	18300822	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr22:18300822C>A	ENST00000441493.2	-	26	4957	c.4605G>T	c.(4603-4605)gaG>gaT	p.E1535D		NM_015241.2	NP_056056.2	Q7RTP6	MICA3_HUMAN	microtubule associated monooxygenase, calponin and LIM domain containing 3	1535						cytoplasm|cytoskeleton	monooxygenase activity|zinc ion binding			large_intestine(1)|lung(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	4		all_epithelial(15;0.198)		Lung(27;0.0427)		GGCTTGAGTCCTCAGTCTTGT	0.627000													8	22					0.00307968	0.00324263	1	1	0
SPANXN2	494119	broad.mit.edu	37	X	142795254	142795254	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chrX:142795254C>A	ENST00000370498.1	-	2	1177	c.424G>T	c.(424-426)Gac>Tac	p.D142Y		NM_001009615.1	NP_001009615.1	Q5MJ10	SPXN2_HUMAN	SPANX family, member N2	142										NS(1)|breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(17)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	27	Acute lymphoblastic leukemia(192;6.56e-05)					TCAGATGAGTCCAGGTCTTCG	0.512000													88	91					7.8029e-68	1.3386e-67	1	1	0
NTRK1	4914	broad.mit.edu	37	1	156845419	156845419	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr1:156845419G>A	ENST00000368196.3	+	11	1564	c.1444G>A	c.(1444-1446)Ggc>Agc	p.G482S	NTRK1_ENST00000392302.2_Missense_Mutation_p.G452S|NTRK1_ENST00000524377.1_Missense_Mutation_p.G488S|NTRK1_ENST00000358660.3_Missense_Mutation_p.G482S	NM_001012331.1	NP_001012331.1	P04629	NTRK1_HUMAN	neurotrophic tyrosine kinase, receptor, type 1	488	Interaction with SQSTM1 (By similarity).				activation of adenylate cyclase activity|activation of MAPKK activity|activation of phospholipase C activity|cell differentiation|nerve growth factor receptor signaling pathway|nervous system development|phosphatidylinositol-mediated signaling|Ras protein signal transduction	endosome|integral to plasma membrane	ATP binding|neurotrophin receptor activity|transmembrane receptor protein serine/threonine kinase activity|transmembrane receptor protein tyrosine kinase activity			breast(3)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(7)|lung(35)|ovary(8)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	74	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)				Imatinib(DB00619)	TGGGCTCCAAGGCCACATCAT	0.587000			T	"""TPM3, TPR, TFG"""	papillary thyroid					TSP Lung(10;0.080)			22	58					0	0	1	0	0
OR10AG1	282770	broad.mit.edu	37	11	55735796	55735796	+	Silent	SNP	A	A	G			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr11:55735796A>G	ENST00000312345.2	-	1	194	c.144T>C	c.(142-144)acT>acC	p.T48T		NM_001005491.1	NP_001005491.1	Q8NH19	O10AG_HUMAN	olfactory receptor, family 10, subfamily AG, member 1	48					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(24)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)	40	Esophageal squamous(21;0.0137)					AATACATGGGAGTCTGGAGAG	0.338000													6	113					0	0	1	0	0
PCDHA10	56139	broad.mit.edu	37	5	140236822	140236822	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr5:140236822G>T	ENST00000307360.5	+	1	1189	c.1189G>T	c.(1189-1191)Gtg>Ttg	p.V397L	PCDHA10_ENST00000506939.2_Missense_Mutation_p.V397L|PCDHA9_ENST00000532602.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA1_ENST00000394633.3_Intron	NM_018901.2|NM_031859.1	NP_061724.1|NP_114065.1														NS(1)|breast(11)|cervix(1)|endometrium(11)|kidney(5)|large_intestine(13)|liver(2)|lung(20)|ovary(3)|pancreas(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(2)	79			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GTTCAAGCTGGTGTCCACCTA	0.592000													50	212					4.02871e-13	5.52905e-13	1	1	0
TTN	7273	broad.mit.edu	37	2	179545040	179545040	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr2:179545040C>A	ENST00000589042.1	-	139	33583	c.33359G>T	c.(33358-33360)aGg>aTg	p.R11120M	TTN-AS1_ENST00000589487.1_RNA|TTN_ENST00000460472.2_Intron|TTN-AS1_ENST00000589830.1_RNA|TTN_ENST00000359218.5_Intron|TTN_ENST00000342992.6_Missense_Mutation_p.R9876M|TTN_ENST00000342175.6_Intron|TTN-AS1_ENST00000431752.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.R10803M|TTN-AS1_ENST00000585451.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	10803	Glu-rich.|Pro-rich.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TGCGACAACCCTCTTGGGCTT	0.403000													45	143					9.58827e-17	1.40299e-16	1	1	0
SEMA3D	223117	broad.mit.edu	37	7	84629152	84629152	+	Silent	SNP	C	C	A			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr7:84629152C>A	ENST00000284136.6	-	17	1981	c.1938G>T	c.(1936-1938)acG>acT	p.T646T	SEMA3D_ENST00000484038.1_5'UTR	NM_152754.2	NP_689967.2	O95025	SEM3D_HUMAN	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D	646	Ig-like C2-type.				cell differentiation|nervous system development	extracellular region|membrane	receptor activity			NS(1)|breast(2)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(19)|lung(29)|ovary(3)|pancreas(1)|prostate(4)|skin(2)	73						GCCCATATTCCGTTTTGATGA	0.408000													11	23					0.000978159	0.00104652	1	1	0
PBRM1	55193	broad.mit.edu	37	3	52584762	52584762	+	Splice_Site	SNP	C	C	A			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr3:52584762C>A	ENST00000356770.4	-	26	4422		c.e26+1		PBRM1_ENST00000409767.1_Splice_Site|PBRM1_ENST00000409057.1_Splice_Site|PBRM1_ENST00000394830.3_Splice_Site|PBRM1_ENST00000337303.4_Splice_Site|PBRM1_ENST00000296302.7_Splice_Site|PBRM1_ENST00000410007.1_Splice_Site|SMIM4_ENST00000476842.1_Intron|PBRM1_ENST00000409114.3_Splice_Site			Q86U86	PB1_HUMAN	polybromo 1						chromatin remodeling|mitosis|negative regulation of cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear chromosome	chromatin binding|DNA binding|protein binding			breast(5)|endometrium(5)|kidney(301)|liver(1)|lung(22)|pancreas(1)	335				BRCA - Breast invasive adenocarcinoma(193;1.8e-05)|Kidney(197;0.00105)|KIRC - Kidney renal clear cell carcinoma(197;0.00122)|OV - Ovarian serous cystadenocarcinoma(275;0.0613)		GGGAGGCTCACCTGTTGTCCA	0.478000			"""Mis, N, F, S, D, O"""		"""clear cell renal carcinoma, breast"""								19	23					2.94398e-08	3.66158e-08	1	1	0
KIAA0100	9703	broad.mit.edu	37	17	26968943	26968943	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr17:26968943C>A	ENST00000528896.2	-	7	804	c.730G>T	c.(730-732)Ggc>Tgc	p.G244C	KIAA0100_ENST00000389003.3_Missense_Mutation_p.G101C|KIAA0100_ENST00000544884.1_Missense_Mutation_p.G101C	NM_014680.3	NP_055495.2	Q14667	K0100_HUMAN	KIAA0100	244						extracellular region				breast(3)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(13)|lung(23)|ovary(2)|prostate(2)|skin(6)|stomach(2)|urinary_tract(3)	68	Lung NSC(42;0.00431)					AGGCTTGGGCCCTGGCACAGC	0.527000													13	48					0.00136819	0.00145599	1	1	0
HDHD1	8226	broad.mit.edu	37	X	6995490	6995490	+	Splice_Site	SNP	C	C	A			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chrX:6995490C>A	ENST00000381077.5	-	3	357	c.280_splice	c.e3-1	p.G94_splice	HDHD1_ENST00000424830.2_Splice_Site_p.G117_splice|HDHD1_ENST00000412827.2_Splice_Site_p.G51_splice|HDHD1_ENST00000540122.1_Splice_Site_p.G94_splice	NM_001178136.1|NM_012080.4	NP_001171607.1|NP_036212.3	Q08623	HDHD1_HUMAN	haloacid dehalogenase-like hydrolase domain containing 1	94					nucleotide metabolic process		metal ion binding|phosphatase activity			breast(2)|large_intestine(1)|lung(3)	6						TTTCTCCGCCCCTGGGGAGGA	0.612000													8	7					7.48243e-07	8.9699e-07	1	1	0
PLCG2	5336	broad.mit.edu	37	16	81934352	81934352	+	Silent	SNP	G	G	T			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr16:81934352G>T	ENST00000359376.3	+	14	1543	c.1329G>T	c.(1327-1329)tcG>tcT	p.S443S		NM_002661.3	NP_002652.2	P16885	PLCG2_HUMAN	phospholipase C, gamma 2 (phosphatidylinositol-specific)	443	PI-PLC X-box.				intracellular signal transduction|phospholipid catabolic process|platelet activation	plasma membrane	phosphatidylinositol phospholipase C activity|protein binding|signal transducer activity			NS(1)|breast(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(18)|lung(21)|ovary(1)|prostate(2)|skin(2)|urinary_tract(1)	58						AGCTGCCCTCGCCCAGCCAGC	0.637000													14	27					4.14922e-12	5.61697e-12	1	1	0
SLC35F3	148641	broad.mit.edu	37	1	234455930	234455930	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr1:234455930G>T	ENST00000366618.3	+	7	1379	c.1234G>T	c.(1234-1236)Gca>Tca	p.A412S	SLC35F3_ENST00000366617.3_Missense_Mutation_p.A343S	NM_173508.2	NP_775779.1	Q8IY50	S35F3_HUMAN	solute carrier family 35, member F3	343					transport	integral to membrane				breast(2)|endometrium(3)|kidney(2)|large_intestine(7)|lung(13)|ovary(2)|skin(2)|urinary_tract(1)	32	Ovarian(103;0.0454)	all_cancers(173;0.145)|Prostate(94;0.0885)	OV - Ovarian serous cystadenocarcinoma(106;0.00531)			ACCTGTGAATGCAGGTAAACC	0.398000													17	82					3.51602e-12	4.79238e-12	1	1	0
TEP1	7011	broad.mit.edu	37	14	20849819	20849819	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr14:20849819C>A	ENST00000262715.5	-	31	4491	c.4451G>T	c.(4450-4452)cGc>cTc	p.R1484L	TEP1_ENST00000556935.1_Missense_Mutation_p.R1376L|TEP1_ENST00000545983.1_Intron	NM_007110.4	NP_009041.2	Q99973	TEP1_HUMAN	telomerase-associated protein 1	1484	NACHT.				telomere maintenance via recombination	chromosome, telomeric region|cytoplasm|nuclear matrix|soluble fraction|telomerase holoenzyme complex	ATP binding|RNA binding			NS(4)|breast(1)|central_nervous_system(4)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(48)|ovary(7)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	96	all_cancers(95;0.00123)	all_lung(585;0.235)	Epithelial(56;7.42e-08)|all cancers(55;6.46e-07)	GBM - Glioblastoma multiforme(265;0.028)|READ - Rectum adenocarcinoma(17;0.233)		GGCACCAGGGCGCTCCAGAGG	0.617000													30	52					7.26314e-15	1.05501e-14	1	1	0
OR4M2	390538	broad.mit.edu	37	15	22369056	22369056	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr15:22369056G>T	ENST00000332663.2	+	1	579	c.481G>T	c.(481-483)Gct>Tct	p.A161S	RP11-69H14.6_ENST00000558896.1_RNA	NM_001004719.2	NP_001004719.2	Q8NGB6	OR4M2_HUMAN	olfactory receptor, family 4, subfamily M, member 2	161					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(2)|endometrium(2)|kidney(4)|large_intestine(6)|lung(38)|ovary(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(3)	63		all_cancers(20;1.94e-20)|all_epithelial(15;3.94e-18)|Lung NSC(15;8.53e-15)|all_lung(15;2.87e-14)|Breast(32;0.00519)|Colorectal(260;0.101)	GBM - Glioblastoma multiforme(6;0.124)	all cancers(64;1.64e-11)|Epithelial(43;5.81e-10)|BRCA - Breast invasive adenocarcinoma(123;0.000255)|Kidney(6;0.00736)|KIRC - Kidney renal clear cell carcinoma(6;0.0135)|GBM - Glioblastoma multiforme(186;0.0963)		CATACAGGTGGCTCTCATTGT	0.517000													55	263					2.76378e-25	4.43543e-25	1	1	0
WFIKKN2	124857	broad.mit.edu	37	17	48917283	48917283	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr17:48917283C>A	ENST00000311378.4	+	2	1162	c.634C>A	c.(634-636)Ctg>Atg	p.L212M	WFIKKN2_ENST00000426127.1_Missense_Mutation_p.L119M	NM_175575.5	NP_783165.1	Q8TEU8	WFKN2_HUMAN	WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2	212	Ig-like C2-type.					extracellular region	metalloendopeptidase inhibitor activity|protein binding|serine-type endopeptidase inhibitor activity			cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(3)|lung(13)|ovary(4)|skin(1)	29			BRCA - Breast invasive adenocarcinoma(22;1.09e-08)			GGCCCCTGCGCTGCTCAACAA	0.652000													9	49					0.0581538	0.0596526	1	1	0
MAZ	4150	broad.mit.edu	37	16	29821465	29821465	+	Missense_Mutation	SNP	A	A	G			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr16:29821465A>G	ENST00000563402.1	+	3	447	c.316A>G	c.(316-318)Agc>Ggc	p.S106G	MAZ_ENST00000568282.1_3'UTR|MAZ_ENST00000545521.1_Silent_p.V426V|AC009133.14_ENST00000569981.1_RNA|MAZ_ENST00000219782.6_3'UTR|MAZ_ENST00000322945.6_Silent_p.V449V|MAZ_ENST00000568544.1_Silent_p.V50V|AC009133.20_ENST00000569039.1_RNA|MAZ_ENST00000562337.1_Silent_p.V144V|MAZ_ENST00000566906.2_Missense_Mutation_p.S104G			P56270	MAZ_HUMAN	MYC-associated zinc finger protein (purine-binding transcription factor)	106	Poly-Ala.				regulation of transcription, DNA-dependent|termination of RNA polymerase II transcription|transcription initiation from RNA polymerase II promoter	nucleus	DNA binding|protein binding|RNA binding|zinc ion binding			endometrium(3)|lung(4)|ovary(2)|upper_aerodigestive_tract(1)	10						cggcagcagtagcagcCCCTC	0.672000													6	13					0	0	1	0	0
SMG7	9887	broad.mit.edu	37	1	183515445	183515445	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr1:183515445G>T	ENST00000367537.3	+	18	2859	c.2664G>T	c.(2662-2664)caG>caT	p.Q888H	SMG7_ENST00000347615.2_Missense_Mutation_p.Q905H|SMG7_ENST00000515829.2_Missense_Mutation_p.Q859H|SMG7_ENST00000507469.1_Missense_Mutation_p.Q859H|SMG7_ENST00000508461.1_Missense_Mutation_p.Q863H|SMG7_ENST00000456731.2_Missense_Mutation_p.Q817H			Q92540	SMG7_HUMAN	SMG7 nonsense mediated mRNA decay factor	905					mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of dephosphorylation	cytoplasm|intermediate filament cytoskeleton|nucleus	protein phosphatase 2A binding			breast(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(7)|lung(16)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	46						GTCCAGAGCAGGATCCTGTAC	0.473000													22	62					1.36565e-18	2.04333e-18	1	1	0
LRRC75A-AS1	125144	broad.mit.edu	37	17	16342490	16342490	+	RNA	SNP	C	C	T			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr17:16342490C>T	ENST00000475953.1	+	0	132				C17orf76-AS1_ENST00000477249.2_RNA|C17orf76-AS1_ENST00000492250.1_RNA|C17orf76-AS1_ENST00000580770.1_RNA|C17orf76-AS1_ENST00000481898.1_RNA|C17orf76-AS1_ENST00000580180.1_RNA|C17orf76-AS1_ENST00000579473.1_RNA|C17orf76-AS1_ENST00000578380.2_RNA|C17orf76-AS1_ENST00000487066.1_RNA|C17orf76-AS1_ENST00000470491.2_RNA|C17orf76-AS1_ENST00000584177.1_RNA|C17orf76-AS1_ENST00000584926.1_RNA|C17orf76-AS1_ENST00000584141.1_RNA|C17orf76-AS1_ENST00000583400.2_RNA|C17orf76-AS1_ENST00000475947.2_RNA|C17orf76-AS1_ENST00000582911.1_RNA|C17orf76-AS1_ENST00000581913.1_RNA|C17orf76-AS1_ENST00000581718.1_RNA	NR_027667.1																						GGGCGGAGGGCAGCTGTTGAG	0.667000													7	35					0	0	1	0	0
NMUR2	56923	broad.mit.edu	37	5	151777686	151777686	+	Missense_Mutation	SNP	A	A	G			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr5:151777686A>G	ENST00000255262.3	-	2	911	c.746T>C	c.(745-747)cTt>cCt	p.L249P	NMUR2_ENST00000518933.1_5'UTR	NM_020167.4	NP_064552.3	Q9GZQ4	NMUR2_HUMAN	neuromedin U receptor 2	249					activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|arachidonic acid secretion|calcium ion transport|central nervous system development|elevation of cytosolic calcium ion concentration|regulation of smooth muscle contraction	integral to membrane|plasma membrane	GTP binding|intracellular calcium activated chloride channel activity|neuromedin U receptor activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(12)|liver(1)|lung(15)|ovary(3)|pancreas(1)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)	44		Medulloblastoma(196;0.091)|all_hematologic(541;0.103)	Kidney(363;0.000106)|KIRC - Kidney renal clear cell carcinoma(527;0.000672)			ATCTGCCTCAAGAGATTTGTC	0.358000													27	54					0	0	1	0	0
MAX	4149	broad.mit.edu	37	14	65560493	65560493	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr14:65560493C>A	ENST00000284165.6	-	3	252	c.104G>T	c.(103-105)cGt>cTt	p.R35L	MAX_ENST00000358402.4_Missense_Mutation_p.R26L|MAX_ENST00000555932.1_Intron|MAX_ENST00000246163.2_Missense_Mutation_p.R35L|MAX_ENST00000557277.1_5'UTR|MAX_ENST00000358664.4_Missense_Mutation_p.R35L|MAX_ENST00000556979.1_Missense_Mutation_p.R35L|RP11-840I19.3_ENST00000553633.1_RNA|RP11-840I19.3_ENST00000555261.1_RNA|MAX_ENST00000555419.1_Intron|RP11-840I19.3_ENST00000555898.1_RNA|MAX_ENST00000557746.1_Missense_Mutation_p.R26L|MAX_ENST00000556443.1_Missense_Mutation_p.R26L|MAX_ENST00000341653.2_Missense_Mutation_p.R35L|MAX_ENST00000555667.1_Missense_Mutation_p.R26L	NM_145113.1	NP_660088.1	P61244	MAX_HUMAN	MYC associated factor X	35					transcription from RNA polymerase II promoter	cytoplasm|MLL1 complex	sequence-specific DNA binding transcription factor activity|transcription coactivator activity	p.R35H(1)		breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(1)|lung(3)|prostate(1)|skin(1)	17				all cancers(60;0.000776)|OV - Ovarian serous cystadenocarcinoma(108;0.00359)|BRCA - Breast invasive adenocarcinoma(234;0.00999)		GTGGTCCCTACGTTTTCGTTC	0.478000													25	42					2.48779e-11	3.34508e-11	1	1	0
TMEM147	10430	broad.mit.edu	37	19	36038271	36038271	+	Silent	SNP	G	G	T			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr19:36038271G>T	ENST00000392204.2	+	6	778	c.450G>T	c.(448-450)ctG>ctT	p.L150L	TMEM147_ENST00000392205.1_3'UTR|TMEM147_ENST00000222284.5_Silent_p.L199L	NM_001242597.1	NP_001229526.1	Q9BVK8	TM147_HUMAN	transmembrane protein 147	199						endoplasmic reticulum membrane|integral to membrane	protein binding			endometrium(1)|large_intestine(2)|lung(2)|prostate(1)	6	all_lung(56;1.05e-07)|Lung NSC(56;1.63e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0724)			CAGCTCTACTGGCCCGAGCAG	0.562000													3	50					1	1	1	1	0
OR11L1	391189	broad.mit.edu	37	1	248004356	248004356	+	Silent	SNP	G	G	T			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr1:248004356G>T	ENST00000355784.2	-	1	898	c.843C>A	c.(841-843)gtC>gtA	p.V281V		NM_001001959.1	NP_001001959.1	Q8NGX0	O11L1_HUMAN	olfactory receptor, family 11, subfamily L, member 1	281					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(4)|kidney(5)|large_intestine(5)|lung(35)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	57	all_cancers(71;8.78e-05)|all_epithelial(71;9.15e-06)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.0786)|Lung NSC(105;0.0858)		OV - Ovarian serous cystadenocarcinoma(106;0.0319)			GCAGTGGTGTGACCACAGTGT	0.443000													20	88					3.62473e-10	4.62386e-10	1	1	0
TOPORS	10210	broad.mit.edu	37	9	32541434	32541434	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr9:32541434C>A	ENST00000360538.2	-	3	3205	c.3089G>T	c.(3088-3090)cGg>cTg	p.R1030L	TOPORS_ENST00000379858.1_Missense_Mutation_p.R965L	NM_005802.4	NP_005793.2	Q9NS56	TOPRS_HUMAN	topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase	1030					DNA damage response, signal transduction resulting in induction of apoptosis|maintenance of protein location in nucleus|proteasomal ubiquitin-dependent protein catabolic process|protein sumoylation|transcription, DNA-dependent	nuclear speck|PML body	antigen binding|DNA binding|DNA topoisomerase I binding|SUMO ligase activity|ubiquitin-protein ligase activity|zinc ion binding			large_intestine(6)|ovary(3)|skin(2)|upper_aerodigestive_tract(1)	12			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.0018)		TAATGATGTCCGTGGCGATGG	0.393000													21	56					1.01871e-10	1.31639e-10	1	1	0
PASD1	139135	broad.mit.edu	37	X	150832592	150832592	+	Splice_Site	SNP	C	C	G			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chrX:150832592C>G	ENST00000370357.4	+	11	1088	c.841_splice	c.e11-1	p.A281_splice		NM_173493.2	NP_775764.2	Q8IV76	PASD1_HUMAN	PAS domain containing 1	281						nucleus	signal transducer activity			breast(2)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(3)|liver(1)|lung(25)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	48	Acute lymphoblastic leukemia(192;6.56e-05)					CTTCCTCAGCCTTATCCTTGC	0.468000													28	14					0	0	1	0	0
EMR2	30817	broad.mit.edu	37	19	14875377	14875377	+	Missense_Mutation	SNP	G	G	T	rs150544869		TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr19:14875377G>T	ENST00000315576.3	-	11	1403	c.952C>A	c.(952-954)Ctg>Atg	p.L318M	EMR2_ENST00000392964.3_Missense_Mutation_p.L57M|EMR2_ENST00000353005.1_Missense_Mutation_p.L176M|EMR2_ENST00000596991.2_Missense_Mutation_p.L318M|EMR2_ENST00000595839.1_Missense_Mutation_p.L176M|EMR2_ENST00000346057.1_Missense_Mutation_p.L269M|EMR2_ENST00000594076.1_Missense_Mutation_p.L225M|EMR2_ENST00000594294.1_Missense_Mutation_p.L269M|EMR2_ENST00000601345.1_Missense_Mutation_p.L318M|EMR2_ENST00000392967.2_Missense_Mutation_p.L318M|EMR2_ENST00000392965.3_Missense_Mutation_p.L318M|EMR2_ENST00000353876.1_Missense_Mutation_p.L225M	NM_013447.2	NP_038475.2	Q9UHX3	EMR2_HUMAN	egf-like module containing, mucin-like, hormone receptor-like 2	318					cell adhesion|neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			breast(1)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(8)|lung(19)|ovary(1)|prostate(2)|skin(6)|upper_aerodigestive_tract(1)	48						AGGGTCTCCAGGTCCCCAGGG	0.612000													11	49					1.08611e-07	1.30991e-07	1	1	0
EVX2	344191	broad.mit.edu	37	2	176947074	176947074	+	Silent	SNP	C	C	T			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr2:176947074C>T	ENST00000308618.4	-	2	667	c.531G>A	c.(529-531)gcG>gcA	p.A177A		NM_001080458.1	NP_001073927.1	Q03828	EVX2_HUMAN	even-skipped homeobox 2	177						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			kidney(1)|large_intestine(3)|liver(1)|lung(8)|ovary(3)	16			OV - Ovarian serous cystadenocarcinoma(117;0.0207)|Epithelial(96;0.18)	READ - Rectum adenocarcinoma(9;0.0678)|Colorectal(32;0.115)		AGCCACCCAGCGCCGCGCTCC	0.721000													4	7					0	0	1	0	0
ADAMTS12	81792	broad.mit.edu	37	5	33624444	33624444	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr5:33624444C>T	ENST00000504830.1	-	14	2370	c.2035G>A	c.(2035-2037)Gac>Aac	p.D679N	ADAMTS12_ENST00000352040.3_Intron|ADAMTS12_ENST00000504582.1_5'UTR	NM_030955.2	NP_112217.2	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 12	679	Cys-rich.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(7)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(11)|large_intestine(31)|liver(1)|lung(135)|ovary(4)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(5)	216						ATCTCATAGTCACAGCCAACC	0.542000										HNSCC(64;0.19)			29	36					0	0	1	0	0
KBTBD7	84078	broad.mit.edu	37	13	41768338	41768338	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr13:41768338C>T	ENST00000379483.3	-	1	364	c.56G>A	c.(55-57)gGg>gAg	p.G19E		NM_032138.4	NP_115514.2	Q8WVZ9	KBTB7_HUMAN	kelch repeat and BTB (POZ) domain containing 7	19							protein binding			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|liver(1)|lung(8)|ovary(4)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	24		Lung NSC(96;0.000105)|Breast(139;0.00715)|Prostate(109;0.0233)|Lung SC(185;0.0367)		all cancers(112;6.21e-09)|Epithelial(112;6.99e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000196)|GBM - Glioblastoma multiforme(144;0.000857)|BRCA - Breast invasive adenocarcinoma(63;0.0669)		GGGCCGCCTCCCACCACGGGG	0.657000													7	118					0	0	1	0	0
GALNT8	26290	broad.mit.edu	37	12	4881631	4881631	+	Missense_Mutation	SNP	A	A	C			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr12:4881631A>C	ENST00000252318.2	+	11	2119	c.1782A>C	c.(1780-1782)agA>agC	p.R594S		NM_017417.1	NP_059113.1	Q9NY28	GALT8_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 8 (GalNAc-T8)	594	Ricin B-type lectin.					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(13)|ovary(2)|pancreas(1)|prostate(4)|skin(2)|urinary_tract(1)	35						TCATAAACAGAGATACCAAGC	0.522000													21	57					0	0	1	0	0
OR2L3	391192	broad.mit.edu	37	1	248224693	248224693	+	Missense_Mutation	SNP	A	A	G			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr1:248224693A>G	ENST00000359959.3	+	1	710	c.710A>G	c.(709-711)tAc>tGc	p.Y237C	OR2L13_ENST00000366478.2_Intron	NM_001004687.1	NP_001004687.1	Q8NG85	OR2L3_HUMAN	olfactory receptor, family 2, subfamily L, member 3	237					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|endometrium(2)|large_intestine(7)|lung(28)|prostate(1)|skin(1)|urinary_tract(1)	41	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0278)			AAGAAAGCCTACCTGACCTGC	0.473000													130	173					0	0	1	0	0
OC90	729330	broad.mit.edu	37	8	133048637	133048637	+	Silent	SNP	C	C	G			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr8:133048637C>G	ENST00000262283.5	-	13	1395	c.1296G>C	c.(1294-1296)ctG>ctC	p.L432L	OC90_ENST00000254627.3_Intron|OC90_ENST00000443356.2_Silent_p.L236L|OC90_ENST00000603859.1_Intron			Q02509	OC90_HUMAN	otoconin 90	236	Phospholipase A2-like 3.				lipid catabolic process|phospholipid metabolic process		calcium ion binding|phospholipase A2 activity			NS(1)|breast(1)|central_nervous_system(3)|endometrium(1)|kidney(1)|large_intestine(3)|lung(23)|ovary(2)|prostate(1)|skin(1)	37	Esophageal squamous(12;0.00693)|Ovarian(258;0.00769)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000805)			AGAGAGTGATCAGTCTGTCAG	0.433000													18	55					0	0	1	0	0
OR13F1	138805	broad.mit.edu	37	9	107267390	107267390	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	a53ffcc4-1471-4a5a-8f8a-1921eae48392	g.chr9:107267390C>A	ENST00000334726.2	+	1	936	c.847C>A	c.(847-849)Ccc>Acc	p.P283T		NM_001004485.1	NP_001004485.1	Q8NGS4	O13F1_HUMAN	olfactory receptor, family 13, subfamily F, member 1	283					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|large_intestine(6)|lung(17)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	31						CGGACAAACCCCCATGTTGAA	0.418000													24	49					9.57634e-11	1.27256e-10	1	1	0
COL18A1	80781	broad.mit.edu	37	21	46896293	46896293	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	a53ffcc4-1471-4a5a-8f8a-1921eae48392	g.chr21:46896293C>T	ENST00000359759.4	+	5	2093	c.2072C>T	c.(2071-2073)gCg>gTg	p.A691V	COL18A1_ENST00000355480.5_Missense_Mutation_p.A456V|COL18A1_ENST00000400337.2_Missense_Mutation_p.A276V			P39060	COIA1_HUMAN	collagen, type XVIII, alpha 1	691	Nonhelical region 1 (NC1).				cell adhesion|negative regulation of cell proliferation|organ morphogenesis|visual perception	collagen|extracellular space	extracellular matrix structural constituent|metal ion binding|protein binding			breast(1)|central_nervous_system(2)|endometrium(4)|kidney(2)|large_intestine(4)|lung(8)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	25				Colorectal(79;0.0157)|READ - Rectum adenocarcinoma(84;0.0929)		AGGCTCCCCGCGCCACCCCCC	0.637000													9	27					0	0	1	0	0
BTNL2	56244	broad.mit.edu	37	6	32374895	32374895	+	Silent	SNP	C	C	T			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	a53ffcc4-1471-4a5a-8f8a-1921eae48392	g.chr6:32374895C>T	ENST00000454136.3	-	1	10	c.6G>A	c.(4-6)gtG>gtA	p.V2V	BTNL2_ENST00000374995.3_Silent_p.V2V|BTNL2_ENST00000374993.1_Silent_p.V2V|BTNL2_ENST00000540315.1_Silent_p.V2V|BTNL2_ENST00000429232.2_Silent_p.V2V|BTNL2_ENST00000544175.1_5'UTR|BTNL2_ENST00000414363.1_Silent_p.V2V			Q9UIR0	BTNL2_HUMAN	butyrophilin-like 2 (MHC class II associated)	2						integral to membrane				central_nervous_system(3)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(5)|prostate(1)|urinary_tract(1)	19						CTGGAAAATCCACCATCCTCC	0.507000													27	58					0	0	1	0	0
SPTA1	6708	broad.mit.edu	37	1	158619707	158619707	+	Missense_Mutation	SNP	T	T	A			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	a53ffcc4-1471-4a5a-8f8a-1921eae48392	g.chr1:158619707T>A	ENST00000368148.3	-	25	3688	c.3508A>T	c.(3508-3510)Agg>Tgg	p.R1170W	SPTA1_ENST00000368147.3_Missense_Mutation_p.R1170W	NM_003126.2	NP_003117.2	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1 (elliptocytosis 2)	1170					actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			NS(3)|breast(7)|cervix(1)|endometrium(22)|kidney(9)|large_intestine(29)|liver(2)|lung(183)|ovary(5)|prostate(18)|skin(11)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(6)	307	all_hematologic(112;0.0378)					TCTGCAAGCCTCTGCAAAGAA	0.458000													11	36					0	0	1	0	0
KLHDC8A	55220	broad.mit.edu	37	1	205308439	205308439	+	Missense_Mutation	SNP	A	A	C			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	a53ffcc4-1471-4a5a-8f8a-1921eae48392	g.chr1:205308439A>C	ENST00000367156.3	-	7	1456	c.640T>G	c.(640-642)Ttc>Gtc	p.F214V	KLHDC8A_ENST00000539253.1_Missense_Mutation_p.F214V|KLHDC8A_ENST00000537168.1_Missense_Mutation_p.F101V|KLHDC8A_ENST00000367155.3_Missense_Mutation_p.F214V|KLHDC8A_ENST00000460687.1_Missense_Mutation_p.F80V	NM_001271863.1	NP_001258792.1	Q8IYD2	KLD8A_HUMAN	kelch domain containing 8A	214										breast(1)|endometrium(3)|large_intestine(1)|lung(4)|ovary(1)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	14	Breast(84;0.23)		BRCA - Breast invasive adenocarcinoma(75;0.117)			AAGCTGGAGAAGGCCCGCTTA	0.582000													11	41					0	0	1	0	0
ZNF431	170959	broad.mit.edu	37	19	21365588	21365588	+	Missense_Mutation	SNP	A	A	G			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	a53ffcc4-1471-4a5a-8f8a-1921eae48392	g.chr19:21365588A>G	ENST00000311048.7	+	5	626	c.482A>G	c.(481-483)tAt>tGt	p.Y161C	ZNF431_ENST00000594425.1_Intron|ZNF431_ENST00000600692.1_3'UTR	NM_133473.2	NP_597730.2	Q8TF32	ZN431_HUMAN	zinc finger protein 431	161					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(2)|endometrium(4)|large_intestine(7)|lung(7)|skin(1)|upper_aerodigestive_tract(1)	23						AAAGAAGGTTATAATGAGCTA	0.328000													14	47					0	0	1	0	0
PTPRN	5798	broad.mit.edu	37	2	220164773	220164773	+	Missense_Mutation	SNP	G	G	C			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	a53ffcc4-1471-4a5a-8f8a-1921eae48392	g.chr2:220164773G>C	ENST00000295718.2	-	9	1610	c.1370C>G	c.(1369-1371)aCg>aGg	p.T457R	PTPRN_ENST00000423636.2_Missense_Mutation_p.T367R|PTPRN_ENST00000409251.3_Missense_Mutation_p.T457R|AC114803.3_ENST00000417355.1_RNA	NM_002846.3	NP_002837.1	Q16849	PTPRN_HUMAN	protein tyrosine phosphatase, receptor type, N	457					response to reactive oxygen species	integral to plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			breast(3)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(28)|ovary(3)|prostate(4)|skin(11)|upper_aerodigestive_tract(1)|urinary_tract(1)	65		Renal(207;0.0474)		Epithelial(149;4.22e-07)|all cancers(144;8.82e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)|STAD - Stomach adenocarcinoma(1183;0.0875)		TCCTGCCACCGTGGGCTGGCT	0.602000													21	68					0	0	1	0	0
DAK	26007	broad.mit.edu	37	11	61109956	61109956	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	a53ffcc4-1471-4a5a-8f8a-1921eae48392	g.chr11:61109956C>T	ENST00000394900.3	+	8	908	c.679C>T	c.(679-681)Cgc>Tgc	p.R227C		NM_015533.3	NP_056348.2	Q3LXA3	DHAK_HUMAN	dihydroxyacetone kinase 2 homolog (S. cerevisiae)	227	DhaK.				glycerol metabolic process	cytosol	ATP binding|FAD-AMP lyase (cyclizing) activity|glycerone kinase activity|metal ion binding			NS(1)|breast(3)|endometrium(3)|large_intestine(5)|lung(8)|prostate(2)|upper_aerodigestive_tract(1)	23						AGCTGGTGTGCGCCGGATAAA	0.592000													19	88					0	0	1	0	0
ZNF471	57573	broad.mit.edu	37	19	57037191	57037191	+	Silent	SNP	C	C	T			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	a53ffcc4-1471-4a5a-8f8a-1921eae48392	g.chr19:57037191C>T	ENST00000308031.5	+	5	1888	c.1755C>T	c.(1753-1755)tcC>tcT	p.S585S	ZNF471_ENST00000591537.1_3'UTR|ZNF471_ENST00000593197.1_3'UTR	NM_020813.2	NP_065864.2	Q9BX82	ZN471_HUMAN	zinc finger protein 471	585					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|liver(2)|lung(8)|ovary(1)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	36		Colorectal(82;5.46e-05)|Ovarian(87;0.0822)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0307)		ATAGCTCATCCTGTGCTCAGC	0.403000													4	83					0	0	1	0	0
CRB1	23418	broad.mit.edu	37	1	197397003	197397003	+	Missense_Mutation	SNP	G	G	A	rs62636270		TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	a53ffcc4-1471-4a5a-8f8a-1921eae48392	g.chr1:197397003G>A	ENST00000367397.1	+	3	1549	c.691G>A	c.(691-693)Ggc>Agc	p.G231S	CRB1_ENST00000544212.1_Missense_Mutation_p.G331S|CRB1_ENST00000367400.3_Missense_Mutation_p.G850S|CRB1_ENST00000535699.1_Missense_Mutation_p.G781S|CRB1_ENST00000367399.2_Missense_Mutation_p.G738S|CRB1_ENST00000538660.1_Intron			P82279	CRUM1_HUMAN	crumbs homolog 1 (Drosophila)	850	EGF-like 6; calcium-binding (Potential).				cell-cell signaling|establishment or maintenance of cell polarity	apical plasma membrane|extracellular region|integral to membrane	calcium ion binding|protein binding			NS(1)|breast(4)|central_nervous_system(2)|cervix(3)|endometrium(13)|kidney(4)|large_intestine(21)|lung(58)|ovary(7)|prostate(3)|skin(10)|upper_aerodigestive_tract(4)|urinary_tract(2)	132						ATTCTTCAAAGGCTGTATCCA	0.393000													17	65					0	0	1	0	0
RBM10	8241	broad.mit.edu	37	X	47044523	47044523	+	Nonsense_Mutation	SNP	C	C	T			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	a53ffcc4-1471-4a5a-8f8a-1921eae48392	g.chrX:47044523C>T	ENST00000377604.3	+	18	2762	c.2020C>T	c.(2020-2022)Cag>Tag	p.Q674*	RBM10_ENST00000345781.6_Nonsense_Mutation_p.Q597*|RBM10_ENST00000468791.1_Intron|RBM10_ENST00000329236.7_Nonsense_Mutation_p.Q596*	NM_001204467.1|NM_001204468.1|NM_005676.4	NP_001191396.1|NP_001191397.1|NP_005667.2	P98175	RBM10_HUMAN	RNA binding motif protein 10	674					mRNA processing|RNA splicing	chromatin remodeling complex	nucleotide binding|RNA binding|zinc ion binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(8)|large_intestine(10)|liver(1)|lung(14)|ovary(2)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	48						AAATAGCTTCCAGCCTATCAG	0.567000													19	14					0	0	1	0	0
SELENBP1	8991	broad.mit.edu	37	1	151341499	151341499	+	Missense_Mutation	SNP	C	C	A	rs150747769	by1000genomes	TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	a53ffcc4-1471-4a5a-8f8a-1921eae48392	g.chr1:151341499C>A	ENST00000426705.2	-	4	611	c.467G>T	c.(466-468)cGg>cTg	p.R156L	SELENBP1_ENST00000435071.1_Missense_Mutation_p.R50L|SELENBP1_ENST00000447402.3_Intron|SELENBP1_ENST00000473693.1_5'UTR|SELENBP1_ENST00000368868.5_Missense_Mutation_p.R114L	NM_001258289.1	NP_001245218.1	Q13228	SBP1_HUMAN	selenium binding protein 1	114					protein transport	cytosol|membrane|nucleolus	protein binding|selenium binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(11)|prostate(1)|urinary_tract(1)	20	Lung SC(34;0.00471)|Ovarian(49;0.00871)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)			CTTTGGGGCCCGGGGCTCAGA	0.607000													16	76					6.31663e-08	7.86599e-08	1	1	0
KCNQ2	3785	broad.mit.edu	37	20	62071028	62071028	+	Missense_Mutation	SNP	A	A	C			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	a53ffcc4-1471-4a5a-8f8a-1921eae48392	g.chr20:62071028A>C	ENST00000354587.3	-	6	1026	c.850T>G	c.(850-852)Tac>Gac	p.Y284D	KCNQ2_ENST00000344425.5_Missense_Mutation_p.Y284D|KCNQ2_ENST00000370221.1_Missense_Mutation_p.Y284D|KCNQ2_ENST00000430658.1_Missense_Mutation_p.Y284D|KCNQ2_ENST00000370224.1_Missense_Mutation_p.Y284D|KCNQ2_ENST00000359689.1_Missense_Mutation_p.Y284D|KCNQ2_ENST00000357249.2_Missense_Mutation_p.Y284D|KCNQ2_ENST00000359125.2_Missense_Mutation_p.Y284D|KCNQ2_ENST00000344462.3_Missense_Mutation_p.Y284D|KCNQ2_ENST00000370222.3_Missense_Mutation_p.Y284D|KCNQ2_ENST00000370226.1_Missense_Mutation_p.Y284D|KCNQ2_ENST00000360480.3_Missense_Mutation_p.Y284D			O43526	KCNQ2_HUMAN	potassium voltage-gated channel, KQT-like subfamily, member 2	284			Y -> C (in EBN1; 30%-60% reduction of wt heteromeric current. Ratio 1:1 or 20%- 30%; ratio of 1:1:2; dbSNP:rs28939683).		axon guidance|synaptic transmission	voltage-gated potassium channel complex	voltage-gated potassium channel activity			biliary_tract(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(4)|liver(1)|lung(30)|ovary(2)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)	65	all_cancers(38;1.24e-11)		BRCA - Breast invasive adenocarcinoma(10;1.04e-05)		Amitriptyline(DB00321)	GTCTGGGGGTACTTGTCCCCG	0.642000													14	61					0	0	1	0	0
ACTN1	87	broad.mit.edu	37	14	69376758	69376758	+	Splice_Site	SNP	C	C	G			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	a53ffcc4-1471-4a5a-8f8a-1921eae48392	g.chr14:69376758C>G	ENST00000193403.6	-	5	812	c.427_splice	c.e5-1	p.E143_splice	ACTN1_ENST00000394419.4_Splice_Site_p.E143_splice|ACTN1_ENST00000538545.2_Splice_Site_p.E143_splice|ACTN1_ENST00000438964.2_Splice_Site_p.E143_splice|ACTN1_ENST00000554508.1_5'UTR|ACTN1_ENST00000376839.3_Splice_Site_p.E78_splice	NM_001102.3	NP_001093.1	P12814	ACTN1_HUMAN	actinin, alpha 1	143	Actin-binding.				focal adhesion assembly|negative regulation of cellular component movement|platelet activation|platelet degranulation|regulation of apoptosis	actin cytoskeleton|cytosol|extracellular region|focal adhesion|nucleolus|platelet alpha granule lumen|pseudopodium|sarcomere	actin binding|calcium ion binding|integrin binding|vinculin binding			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(5)|lung(9)|prostate(2)|urinary_tract(1)	27				BRCA - Breast invasive adenocarcinoma(234;0.00605)|all cancers(60;0.00846)|OV - Ovarian serous cystadenocarcinoma(108;0.0654)		TGGCTGAAGTCTCTATGGGGA	0.572000													16	17					0	0	1	0	0
FBN1	2200	broad.mit.edu	37	15	48718047	48718047	+	Missense_Mutation	SNP	T	T	C			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	a53ffcc4-1471-4a5a-8f8a-1921eae48392	g.chr15:48718047T>C	ENST00000316623.5	-	59	7674	c.7219A>G	c.(7219-7221)Aag>Gag	p.K2407E		NM_000138.4	NP_000129.3	P35555	FBN1_HUMAN	fibrillin 1	2407	EGF-like 41; calcium-binding.				heart development|negative regulation of BMP signaling pathway by extracellular sequestering of BMP|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|skeletal system development	basement membrane|extracellular space|microfibril	calcium ion binding|extracellular matrix structural constituent|protein binding			NS(1)|breast(5)|cervix(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(43)|liver(1)|lung(49)|ovary(4)|pancreas(1)|prostate(9)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	139		all_lung(180;0.00279)		all cancers(107;4.24e-07)|GBM - Glioblastoma multiforme(94;1.41e-05)		TGAATAACCTTGCATTCATCG	0.328000													18	37					0	0	1	0	0
TGM7	116179	broad.mit.edu	37	15	43577088	43577088	+	Missense_Mutation	SNP	C	C	G			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	a53ffcc4-1471-4a5a-8f8a-1921eae48392	g.chr15:43577088C>G	ENST00000452443.2	-	7	932	c.928G>C	c.(928-930)Gat>Cat	p.D310H		NM_052955.2	NP_443187.1	Q96PF1	TGM7_HUMAN	transglutaminase 7	310					peptide cross-linking		acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(3)|large_intestine(8)|lung(16)|ovary(2)|prostate(4)|skin(1)	39		all_cancers(109;2.12e-14)|all_epithelial(112;1.99e-12)|Lung NSC(122;2.46e-08)|all_lung(180;2.75e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;9.14e-07)	L-Glutamine(DB00130)	AAGTTCCTATCCACGTTGTGC	0.433000													33	103					0	0	1	0	0
IGFBP2	3485	broad.mit.edu	37	2	217498633	217498633	+	Silent	SNP	C	C	T			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	a53ffcc4-1471-4a5a-8f8a-1921eae48392	g.chr2:217498633C>T	ENST00000233809.4	+	1	516	c.387C>T	c.(385-387)ggC>ggT	p.G129G		NM_000597.2	NP_000588.2	P18065	IBP2_HUMAN	insulin-like growth factor binding protein 2, 36kDa	129	IGFBP N-terminal.				positive regulation of activated T cell proliferation|regulation of cell growth|regulation of insulin-like growth factor receptor signaling pathway	extracellular space	insulin-like growth factor I binding|insulin-like growth factor II binding	p.G129G(1)		endometrium(2)|large_intestine(1)|lung(2)	5		Renal(323;0.0458)		Epithelial(149;2.9e-06)|all cancers(144;0.000223)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00968)		TGGGCGAGGGCACTTGTGAGA	0.687000													5	5					0	0	1	0	0
ZNF492	57615	broad.mit.edu	37	19	22847904	22847904	+	Missense_Mutation	SNP	A	A	T			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	a53ffcc4-1471-4a5a-8f8a-1921eae48392	g.chr19:22847904A>T	ENST00000456783.2	+	4	1677	c.1433A>T	c.(1432-1434)aAg>aTg	p.K478M		NM_020855.2	NP_065906.1	Q9P255	ZN492_HUMAN	zinc finger protein 492	478					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|kidney(1)|large_intestine(6)|lung(10)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	21		all_cancers(12;0.0266)|all_lung(12;0.00187)|Lung NSC(12;0.0019)|all_epithelial(12;0.00203)|Hepatocellular(1079;0.244)				AAACCCTACAAGTGTGAAGAA	0.388000													13	31					0	0	1	0	0
OMG	4974	broad.mit.edu	37	17	29622866	29622866	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	a53ffcc4-1471-4a5a-8f8a-1921eae48392	g.chr17:29622866G>T	ENST00000247271.4	-	2	745	c.484C>A	c.(484-486)Cca>Aca	p.P162T	NF1_ENST00000356175.3_Intron|NF1_ENST00000358273.4_Intron	NM_002544.4	NP_002535.3	P23515	OMGP_HUMAN	oligodendrocyte myelin glycoprotein	162					cell adhesion|negative regulation of axonogenesis|nerve growth factor receptor signaling pathway	anchored to membrane|plasma membrane		p.0?(8)|p.?(3)		breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(1)|ovary(1)|prostate(1)|stomach(1)	13		all_cancers(10;6.97e-11)|all_epithelial(10;0.0051)|all_hematologic(16;0.0149)|Breast(31;0.0155)|Myeloproliferative disorder(56;0.0255)|Acute lymphoblastic leukemia(14;0.0257)|all_lung(9;0.0468)|Lung NSC(157;0.094)		UCEC - Uterine corpus endometrioid carcinoma (4;6.64e-05)|all cancers(4;1.81e-13)|Epithelial(4;4.04e-12)|OV - Ovarian serous cystadenocarcinoma(4;9.49e-12)|GBM - Glioblastoma multiforme(4;0.121)		ATGTTGGTTGGAACTGTCCAA	0.383000													42	115					6.33695e-27	1.03696e-26	1	1	0
SPPL2C	162540	broad.mit.edu	37	17	43922518	43922518	+	Silent	SNP	C	C	A			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	a53ffcc4-1471-4a5a-8f8a-1921eae48392	g.chr17:43922518C>A	ENST00000329196.5	+	1	263	c.246C>A	c.(244-246)cgC>cgA	p.R82R	MAPT-AS1_ENST00000579599.1_RNA|MAPT-AS1_ENST00000579244.1_RNA	NM_175882.2	NP_787078.2	Q8IUH8	IMP5_HUMAN	signal peptide peptidase like 2C	82						integral to membrane	aspartic-type endopeptidase activity										CCCAGCTCCGCTCCCCCAGCC	0.692000													9	16					0.00448238	0.00472081	1	1	0
PRSS35	167681	broad.mit.edu	37	6	84234289	84234289	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	a53ffcc4-1471-4a5a-8f8a-1921eae48392	g.chr6:84234289G>T	ENST00000536636.1	+	3	1474	c.1129G>T	c.(1129-1131)Gat>Tat	p.D377Y	PRSS35_ENST00000369700.3_Missense_Mutation_p.D377Y	NM_001170423.1	NP_001163894.1	Q8N3Z0	PRS35_HUMAN	protease, serine, 35	377	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			breast(2)|endometrium(2)|large_intestine(12)|lung(11)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	32		all_cancers(76;0.000113)|Acute lymphoblastic leukemia(125;1.09e-08)|all_hematologic(105;3.12e-05)|all_epithelial(107;0.0575)		BRCA - Breast invasive adenocarcinoma(397;0.0768)		CCAGTGGGTGGATGTCCACGG	0.527000													9	37					0.0581538	0.0596603	1	1	0
RAB3IP	117177	broad.mit.edu	37	12	70178569	70178569	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	a53ffcc4-1471-4a5a-8f8a-1921eae48392	g.chr12:70178569G>A	ENST00000550536.1	+	4	1085	c.628G>A	c.(628-630)Gaa>Aaa	p.E210K	RAB3IP_ENST00000553099.1_5'UTR|RAB3IP_ENST00000325555.9_5'UTR|RAB3IP_ENST00000551641.1_5'UTR|RAB3IP_ENST00000483530.2_Missense_Mutation_p.E194K|RAB3IP_ENST00000362025.5_Missense_Mutation_p.E210K|RAB3IP_ENST00000378815.6_Missense_Mutation_p.E194K|RAB3IP_ENST00000247833.7_Missense_Mutation_p.E194K	NM_001278402.1|NM_175623.2	NP_001265331.1|NP_783322.1	Q96QF0	RAB3I_HUMAN	RAB3A interacting protein	210					cilium assembly|Golgi to plasma membrane transport|protein localization to organelle|protein transport	actin cortical patch|centrosome|cytosol|lamellipodium|microtubule basal body|nucleus	guanyl-nucleotide exchange factor activity|protein binding			NS(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(11)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	22	Esophageal squamous(21;0.187)		Lung(24;0.000381)|OV - Ovarian serous cystadenocarcinoma(12;0.00168)|STAD - Stomach adenocarcinoma(21;0.00694)			ACAGGAATTGGAAGAACTCAC	0.343000													18	69					0	0	1	0	0
ZP1	22917	broad.mit.edu	37	11	60642986	60642986	+	Splice_Site	SNP	G	G	C			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	a53ffcc4-1471-4a5a-8f8a-1921eae48392	g.chr11:60642986G>C	ENST00000278853.5	+	12	1774		c.e12-1			NM_207341.2	NP_997224.2	P60852	ZP1_HUMAN	zona pellucida glycoprotein 1 (sperm receptor)						single fertilization	integral to membrane|plasma membrane|proteinaceous extracellular matrix				breast(3)|endometrium(2)|large_intestine(8)|lung(8)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	26						CTCTCTGACAGACTCCAATGG	0.592000													8	23					0	0	1	0	0
SRPX	8406	broad.mit.edu	37	X	38024106	38024106	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	a53ffcc4-1471-4a5a-8f8a-1921eae48392	g.chrX:38024106C>A	ENST00000378533.3	-	5	675	c.569G>T	c.(568-570)cGc>cTc	p.R190L	SRPX_ENST00000343800.6_Missense_Mutation_p.R177L|TM4SF2_ENST00000465127.1_Intron|SRPX_ENST00000538295.1_Missense_Mutation_p.R190L|SRPX_ENST00000432886.2_Missense_Mutation_p.R131L|SRPX_ENST00000544439.1_Missense_Mutation_p.R170L	NM_006307.4	NP_006298.1	P78539	SRPX_HUMAN	sushi-repeat containing protein, X-linked	190	HYR.				cell adhesion	cell surface|membrane		p.R190H(1)		autonomic_ganglia(1)|breast(2)|endometrium(5)|large_intestine(5)|lung(10)|prostate(2)	25						TTCTGCAATGCGTTCCTTCAC	0.443000													11	10					3.07112e-06	3.59811e-06	1	1	0
XIRP2	129446	broad.mit.edu	37	2	168107682	168107682	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	a53ffcc4-1471-4a5a-8f8a-1921eae48392	g.chr2:168107682G>T	ENST00000409195.1	+	9	9869	c.9780G>T	c.(9778-9780)gaG>gaT	p.E3260D	XIRP2_ENST00000409043.1_Intron|XIRP2_ENST00000409756.2_Intron|XIRP2_ENST00000295237.9_Missense_Mutation_p.E3260D|XIRP2_ENST00000420519.1_Intron|XIRP2_ENST00000409273.1_Missense_Mutation_p.E3038D|XIRP2_ENST00000409728.1_Intron|XIRP2_ENST00000409605.1_Intron	NM_152381.5	NP_689594.4	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2	3085					actin cytoskeleton organization	cell junction	actin binding	p.E3260E(1)		NS(3)|biliary_tract(2)|breast(5)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(51)|lung(160)|ovary(7)|pancreas(3)|prostate(11)|skin(14)|stomach(5)|upper_aerodigestive_tract(8)|urinary_tract(7)	315						ACGCTCAAGAGGAAATCAGGA	0.423000													22	57					3.5997e-14	5.16479e-14	1	1	0
WFIKKN2	124857	broad.mit.edu	37	17	48917306	48917306	+	Missense_Mutation	SNP	G	G	C			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	a53ffcc4-1471-4a5a-8f8a-1921eae48392	g.chr17:48917306G>C	ENST00000311378.4	+	2	1185	c.657G>C	c.(655-657)caG>caC	p.Q219H	WFIKKN2_ENST00000426127.1_Missense_Mutation_p.Q126H	NM_175575.5	NP_783165.1	Q8TEU8	WFKN2_HUMAN	WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2	219	Ig-like C2-type.					extracellular region	metalloendopeptidase inhibitor activity|protein binding|serine-type endopeptidase inhibitor activity			cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(3)|lung(13)|ovary(4)|skin(1)	29			BRCA - Breast invasive adenocarcinoma(22;1.09e-08)			CTGTGCACCAGTCGGTCACCA	0.642000													13	48					0	0	1	0	0
KCNA4	3739	broad.mit.edu	37	11	30034020	30034020	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	a53ffcc4-1471-4a5a-8f8a-1921eae48392	g.chr11:30034020C>A	ENST00000328224.6	-	2	1439	c.206G>T	c.(205-207)gGg>gTg	p.G69V		NM_002233.3	NP_002224.1	P22459	KCNA4_HUMAN	potassium voltage-gated channel, shaker-related subfamily, member 4	69						voltage-gated potassium channel complex	potassium ion binding|protein binding|voltage-gated potassium channel activity			central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(17)|lung(39)|ovary(3)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(4)|urinary_tract(1)	78						GGTACAGGCCCCGCGTGACTG	0.657000													20	49					8.10497e-08	1.00299e-07	1	1	0
FLNC	2318	broad.mit.edu	37	7	128484144	128484144	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	a53ffcc4-1471-4a5a-8f8a-1921eae48392	g.chr7:128484144C>A	ENST00000325888.8	+	20	3277	c.3016C>A	c.(3016-3018)Ccc>Acc	p.P1006T	FLNC_ENST00000346177.6_Missense_Mutation_p.P1006T	NM_001458.4	NP_001449.3	Q14315	FLNC_HUMAN	filamin C, gamma	1006					cell junction assembly	cytoskeleton|cytosol|plasma membrane|sarcomere	actin binding			biliary_tract(1)|breast(7)|central_nervous_system(1)|cervix(1)|endometrium(19)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(19)|lung(59)|ovary(2)|pancreas(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)	128						GATGACTTCGCCCTCTCGCCG	0.662000													15	30					4.7546e-09	6.03469e-09	1	1	0
ATP8B1	5205	broad.mit.edu	37	18	55359055	55359055	+	Missense_Mutation	SNP	T	T	A			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	a53ffcc4-1471-4a5a-8f8a-1921eae48392	g.chr18:55359055T>A	ENST00000536015.1	-	12	1323	c.1204A>T	c.(1204-1206)Atc>Ttc	p.I402F	ATP8B1_ENST00000283684.4_Missense_Mutation_p.I402F|RP11-35G9.3_ENST00000599199.1_RNA|RP11-35G9.5_ENST00000588925.1_RNA	NM_005603.4	NP_005594.1	O43520	AT8B1_HUMAN	ATPase, aminophospholipid transporter, class I, type 8B, member 1	402					ATP biosynthetic process|bile acid and bile salt transport|negative regulation of transcription, DNA-dependent	apical plasma membrane|integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			breast(6)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(11)|lung(19)|ovary(3)|prostate(1)	53		Colorectal(73;0.229)				TAGAGAGAGATGGGTACCATG	0.443000													16	42					0	0	1	0	0
MICAL3	57553	broad.mit.edu	37	22	18300821	18300821	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	a53ffcc4-1471-4a5a-8f8a-1921eae48392	g.chr22:18300821C>A	ENST00000441493.2	-	26	4958	c.4606G>T	c.(4606-4608)Gac>Tac	p.D1536Y		NM_015241.2	NP_056056.2	Q7RTP6	MICA3_HUMAN	microtubule associated monooxygenase, calponin and LIM domain containing 3	1536						cytoplasm|cytoskeleton	monooxygenase activity|zinc ion binding			large_intestine(1)|lung(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	4		all_epithelial(15;0.198)		Lung(27;0.0427)		AGGCTTGAGTCCTCAGTCTTG	0.627000													8	22					0.00307968	0.00326084	1	1	0
FLG	2312	broad.mit.edu	37	1	152281717	152281717	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	a53ffcc4-1471-4a5a-8f8a-1921eae48392	g.chr1:152281717C>T	ENST00000368799.1	-	3	5680	c.5645G>A	c.(5644-5646)gGg>gAg	p.G1882E	FLG-AS1_ENST00000420707.1_RNA|FLG-AS1_ENST00000593011.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	1882	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GTGACGCGACCCTGAGTGCCT	0.577000									Ichthyosis				98	457					0	0	1	0	0
BAGE2	85319	broad.mit.edu	37	21	11038981	11038981	+	RNA	SNP	T	T	C			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	a53ffcc4-1471-4a5a-8f8a-1921eae48392	g.chr21:11038981T>C	ENST00000470054.1	-	0	1222									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		ATGATAACTTTATAGATTTGC	0.408000													27	451					0	0	1	0	0
ABI3BP	25890	broad.mit.edu	37	3	100567717	100567717	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	a53ffcc4-1471-4a5a-8f8a-1921eae48392	g.chr3:100567717G>T	ENST00000471714.1	-	18	1634	c.1525C>A	c.(1525-1527)Ccc>Acc	p.P509T	ABI3BP_ENST00000284322.5_Missense_Mutation_p.P460T|ABI3BP_ENST00000495063.1_Missense_Mutation_p.P509T			Q7Z7G0	TARSH_HUMAN	ABI family, member 3 (NESH) binding protein	460	Pro-rich.					extracellular space				central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|lung(18)|ovary(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	50						GTTTGCTGGGGAGCTGAAAGA	0.403000													12	46					3.07112e-06	3.59811e-06	1	1	0
RP11-423O2.5	0	broad.mit.edu	37	1	142803427	142803427	+	RNA	SNP	C	C	G			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	a53ffcc4-1471-4a5a-8f8a-1921eae48392	g.chr1:142803427C>G	ENST00000423385.1	-	0	1538																											ctcatcctctcaagtagtttg	0.343000													4	17					0	0	1	0	0
ARPC1B	10095	broad.mit.edu	37	7	98987630	98987630	+	Missense_Mutation	SNP	G	G	C			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	a53ffcc4-1471-4a5a-8f8a-1921eae48392	g.chr7:98987630G>C	ENST00000451682.1	+	7	804	c.495G>C	c.(493-495)aaG>aaC	p.K165N	ARPC1B_ENST00000252725.5_Missense_Mutation_p.K165N			O15143	ARC1B_HUMAN	actin related protein 2/3 complex, subunit 1B, 41kDa	165					cellular component movement|regulation of actin filament polymerization	Arp2/3 protein complex|cytoplasm	actin binding|structural constituent of cytoskeleton			central_nervous_system(1)|endometrium(2)|large_intestine(5)|liver(2)|lung(1)	11	all_cancers(62;3.49e-09)|all_epithelial(64;2.57e-10)|Lung NSC(181;0.0053)|all_lung(186;0.00895)|Esophageal squamous(72;0.0166)		STAD - Stomach adenocarcinoma(171;0.215)			GTGACTTCAAGTGTCGGTGAG	0.622000													37	80					0	0	1	0	0
C15orf41	84529	broad.mit.edu	37	15	37100595	37100595	+	Missense_Mutation	SNP	A	A	G			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	a53ffcc4-1471-4a5a-8f8a-1921eae48392	g.chr15:37100595A>G	ENST00000566621.1	+	11	1037	c.787A>G	c.(787-789)Atc>Gtc	p.I263V	C15orf41_ENST00000338183.4_Missense_Mutation_p.I165V|C15orf41_ENST00000563167.1_Missense_Mutation_p.H25R|C15orf41_ENST00000567389.1_Missense_Mutation_p.I165V|C15orf41_ENST00000565792.1_3'UTR|C15orf41_ENST00000437989.2_Missense_Mutation_p.I263V|CSNK1A1P1_ENST00000430593.3_RNA|C15orf41_ENST00000569302.1_Missense_Mutation_p.I269V|C15orf41_ENST00000562489.1_Missense_Mutation_p.I87V|C15orf41_ENST00000562877.1_Missense_Mutation_p.I165V	NM_001130010.1	NP_001123482.1	Q9Y2V0	CO041_HUMAN	chromosome 15 open reading frame 41	263							protein binding			kidney(1)|large_intestine(3)|lung(6)|ovary(1)|pancreas(1)	12		all_epithelial(112;3.06e-10)|Lung NSC(122;6.48e-08)|all_lung(180;8.31e-07)|Melanoma(134;0.222)		all cancers(64;1.76e-19)|GBM - Glioblastoma multiforme(113;5.03e-07)|BRCA - Breast invasive adenocarcinoma(123;0.11)		GGAAAGGGGCATCCTGCTCAA	0.478000													11	38					0	0	1	0	0
PCDH11X	27328	broad.mit.edu	37	X	91873486	91873486	+	Silent	SNP	C	C	T			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	a53ffcc4-1471-4a5a-8f8a-1921eae48392	g.chrX:91873486C>T	ENST00000373094.1	+	7	4436	c.3591C>T	c.(3589-3591)caC>caT	p.H1197H	PCDH11X_ENST00000298274.8_Silent_p.H1160H|PCDH11X_ENST00000504220.1_3'UTR|PCDH11X_ENST00000406881.1_Silent_p.H1189H|PCDH11X_ENST00000373097.1_Silent_p.H1187H|PCDH11X_ENST00000361655.2_Silent_p.H1179H|PCDH11X_ENST00000373088.1_Silent_p.H1160H	NM_032968.3	NP_116750.1	Q9BZA7	PC11X_HUMAN	protocadherin 11 X-linked	1197					homophilic cell adhesion	integral to plasma membrane	calcium ion binding			NS(1)|autonomic_ganglia(1)|biliary_tract(1)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(30)|liver(4)|lung(92)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	159						CTCTCTGCCACAGCCCTCCAG	0.597000													8	87					0	0	1	0	0
SIGLEC9	27180	broad.mit.edu	37	19	51628630	51628630	+	Silent	SNP	C	C	T			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	a53ffcc4-1471-4a5a-8f8a-1921eae48392	g.chr19:51628630C>T	ENST00000440804.3	+	1	466	c.399C>T	c.(397-399)caC>caT	p.H133H	SIGLEC9_ENST00000250360.3_Silent_p.H133H	NM_001198558.1	NP_001185487.1	Q9Y336	SIGL9_HUMAN	sialic acid binding Ig-like lectin 9	133	Ig-like V-type.				cell adhesion|cell surface receptor linked signaling pathway	integral to plasma membrane	sugar binding			NS(1)|breast(1)|endometrium(3)|kidney(1)|large_intestine(6)|liver(3)|lung(25)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	45		all_neural(266;0.0529)		GBM - Glioblastoma multiforme(134;0.000826)|OV - Ovarian serous cystadenocarcinoma(262;0.00295)		ATAAACATCACCGGCTCTCTG	0.517000													14	43					0	0	1	0	0
SLC17A8	246213	broad.mit.edu	37	12	100806591	100806591	+	Silent	SNP	G	G	A			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	a53ffcc4-1471-4a5a-8f8a-1921eae48392	g.chr12:100806591G>A	ENST00000323346.5	+	10	1543	c.1230G>A	c.(1228-1230)tcG>tcA	p.S410S	SLC17A8_ENST00000552697.1_3'UTR|SLC17A8_ENST00000392989.3_Silent_p.S360S	NM_001145288.1|NM_139319.2	NP_001138760.1|NP_647480.1	Q8NDX2	VGLU3_HUMAN	solute carrier family 17 (vesicular glutamate transporter), member 8	410					neurotransmitter transport|sensory perception of sound|sodium ion transport	cell junction|integral to membrane|synaptic vesicle membrane|synaptosome	L-glutamate transmembrane transporter activity|symporter activity			NS(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(25)|ovary(3)|pancreas(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	44						TTGGCTTTTCGCATACCAAAG	0.448000													31	116					0	0	1	0	0
LOC93432	93432	broad.mit.edu	37	7	141896544	141896544	+	Missense_Mutation	SNP	G	G	C			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	a53ffcc4-1471-4a5a-8f8a-1921eae48392	g.chr7:141896544G>C	ENST00000477922.3	+	40	4614	c.4560G>C	c.(4558-4560)gaG>gaC	p.E1520D																	endometrium(1)|lung(5)	6						CTGAATATGAGATGTGTGTTC	0.483000													8	21					0	0	1	0	0
TEX11	56159	broad.mit.edu	37	X	70127661	70127661	+	Splice_Site	SNP	C	C	A			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	a53ffcc4-1471-4a5a-8f8a-1921eae48392	g.chrX:70127661C>A	ENST00000395889.2	-	2	58		c.e2-1		TEX11_ENST00000374333.2_Splice_Site	NM_001003811.1	NP_001003811.1	Q8IYF3	TEX11_HUMAN	testis expressed 11								protein binding			breast(4)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(12)|lung(13)|ovary(3)|prostate(3)|skin(3)	48	Renal(35;0.156)					TGGCTCAAGCCTGTGAAATAA	0.338000													13	13					0.00010058	0.000111881	1	1	0
KMT2A	4297	broad.mit.edu	37	11	118339515	118339515	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	a53ffcc4-1471-4a5a-8f8a-1921eae48392	g.chr11:118339515C>T	ENST00000534358.1	+	2	481	c.458C>T	c.(457-459)tCa>tTa	p.S153L	KMT2A_ENST00000389506.5_Missense_Mutation_p.S153L|KMT2A_ENST00000354520.4_Missense_Mutation_p.S153L	NM_001197104.1|NM_005933.3	NP_001184033.1|NP_005924.2			lysine (K)-specific methyltransferase 2A																		GGTTTTGGCTCAGATGAAGAA	0.403000													22	51					0	0	1	0	0
GID4	79018	broad.mit.edu	37	17	17948473	17948473	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	a53ffcc4-1471-4a5a-8f8a-1921eae48392	g.chr17:17948473G>T	ENST00000268719.4	+	2	624	c.451G>T	c.(451-453)Ggg>Tgg	p.G151W	GID4_ENST00000376345.3_Missense_Mutation_p.G151W	NM_024052.4	NP_076957.3			GID complex subunit 4																		CGTGGACACGGGGAACTCTTA	0.473000													18	36					1.01871e-10	1.33579e-10	1	1	0
BCL11A	53335	broad.mit.edu	37	2	60689148	60689148	+	Missense_Mutation	SNP	A	A	T			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	a53ffcc4-1471-4a5a-8f8a-1921eae48392	g.chr2:60689148A>T	ENST00000335712.6	-	4	1126	c.899T>A	c.(898-900)gTg>gAg	p.V300E	BCL11A_ENST00000538214.1_Missense_Mutation_p.V266E|BCL11A_ENST00000537768.1_Intron|BCL11A_ENST00000358510.4_Missense_Mutation_p.V266E|BCL11A_ENST00000356842.4_Missense_Mutation_p.V300E|BCL11A_ENST00000477659.1_5'UTR|BCL11A_ENST00000359629.5_Intron	NM_022893.3	NP_075044.2	Q9H165	BC11A_HUMAN	B-cell CLL/lymphoma 11A (zinc finger protein)	300	Pro-rich.				negative regulation of axon extension|negative regulation of collateral sprouting|negative regulation of dendrite development|positive regulation of collateral sprouting|positive regulation of neuron projection development|positive regulation of transcription from RNA polymerase II promoter|protein sumoylation|regulation of dendrite development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	nucleic acid binding|protein heterodimerization activity|protein homodimerization activity|zinc ion binding			NS(1)|breast(6)|central_nervous_system(6)|endometrium(4)|kidney(1)|large_intestine(8)|lung(25)|ovary(2)|pancreas(1)|prostate(2)|skin(3)	59			LUSC - Lung squamous cell carcinoma(5;9.29e-08)|Lung(5;1.34e-06)|Epithelial(17;0.0562)|all cancers(80;0.199)			CAACCGCAGCACCCTGTCAAA	0.612000			T	IGH@	B-CLL								22	64					0	0	1	0	0
SPATA31D5P	347127	broad.mit.edu	37	9	84530312	84530312	+	RNA	SNP	G	G	A			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	a53ffcc4-1471-4a5a-8f8a-1921eae48392	g.chr9:84530312G>A	ENST00000527857.1	+	0	334					NR_026851.1																						TGCAGCTTTGGACCTCCTGCT	0.577000													4	11					0	0	1	0	0
BPIFA3	128861	broad.mit.edu	37	20	31811753	31811753	+	Silent	SNP	G	G	A			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	a53ffcc4-1471-4a5a-8f8a-1921eae48392	g.chr20:31811753G>A	ENST00000375454.3	+	2	474	c.264G>A	c.(262-264)caG>caA	p.Q88Q	BPIFA3_ENST00000375452.3_Silent_p.Q88Q|BPIFA3_ENST00000490499.1_3'UTR	NM_178466.3	NP_848561.2	Q9BQP9	SPLC3_HUMAN	BPI fold containing family A, member 3	88	Poly-Gln.					extracellular region	lipid binding										AACACCAGCAGCAGCAAGAGA	0.572000													4	68					0	0	1	0	0
KRAS	3845	broad.mit.edu	37	12	25398285	25398285	+	Missense_Mutation	SNP	C	C	A	rs121913530		TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	a53ffcc4-1471-4a5a-8f8a-1921eae48392	g.chr12:25398285C>A	ENST00000311936.3	-	2	225	c.34G>T	c.(34-36)Ggt>Tgt	p.G12C	KRAS_ENST00000556131.1_Missense_Mutation_p.G12C|KRAS_ENST00000256078.4_Missense_Mutation_p.G12C|KRAS_ENST00000557334.1_Missense_Mutation_p.G12C	NM_004985.3	NP_004976.2	P01116	RASK_HUMAN	Kirsten rat sarcoma viral oncogene homolog	12			G -> A (in a colorectal cancer sample; somatic mutation).|G -> C (in lung carcinoma; somatic mutation).|G -> D (in pancreatic carcinoma, GASC and lung carcinoma; somatic mutation).|G -> R (in lung cancer and bladder cancer; somatic mutation).|G -> S (in lung carcinoma and GASC; somatic mutation).|G -> V (in lung carcinoma, pancreatic carcinoma, colon cancer and GASC; somatic mutation).		activation of MAPKK activity|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	plasma membrane	GTP binding|GTPase activity|protein binding	p.G12C(3001)|p.G12S(1288)|p.G12R(789)|p.G12F(46)|p.G12L(8)|p.G12I(4)|p.G12W(3)|p.A11_G12insGA(2)|p.G12Y(2)|p.G12N(1)	UBE2L3/KRAS(2)	NS(6)|adrenal_gland(1)|autonomic_ganglia(3)|biliary_tract(532)|bone(2)|breast(32)|central_nervous_system(14)|cervix(50)|endometrium(411)|eye(4)|gastrointestinal_tract_(site_indeterminate)(7)|genital_tract(1)|haematopoietic_and_lymphoid_tissue(385)|kidney(8)|large_intestine(15267)|liver(29)|lung(3407)|oesophagus(16)|ovary(612)|pancreas(3739)|penis(1)|peritoneum(6)|prostate(96)|salivary_gland(6)|skin(45)|small_intestine(68)|soft_tissue(88)|stomach(207)|testis(17)|thymus(5)|thyroid(159)|upper_aerodigestive_tract(68)|urinary_tract(57)	25349	all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)		OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)			CCTACGCCACCAGCTCCAACT	0.348000	G12C(CALU1_LUNG)|G12C(HCC44_LUNG)|G12C(IALM_LUNG)|G12C(KHM1B_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12C(KYSE410_OESOPHAGUS)|G12C(LU65_LUNG)|G12C(LU99_LUNG)|G12C(MIAPACA2_PANCREAS)|G12C(NCIH1373_LUNG)|G12C(NCIH1792_LUNG)|G12C(NCIH2030_LUNG)|G12C(NCIH2122_LUNG)|G12C(NCIH23_LUNG)|G12C(NCIH358_LUNG)|G12C(OV56_OVARY)|G12C(SW1463_LARGE_INTESTINE)|G12C(SW1573_LUNG)|G12C(SW837_LARGE_INTESTINE)|G12C(UMUC3_URINARY_TRACT)|G12R(CAL62_THYROID)|G12R(HS274T_BREAST)|G12R(HUPT3_PANCREAS)|G12R(KP2_PANCREAS)|G12R(PSN1_PANCREAS)|G12R(TCCPAN2_PANCREAS)|G12S(A549_LUNG)|G12S(KMS20_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12S(LS123_LARGE_INTESTINE)	119	Mis		"""pancreatic, colorectal, lung, thyroid, AML, others"""				Noonan syndrome;Cardiofaciocutaneous syndrome	TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)			7	20					2.0095e-06	2.38252e-06	1	1	0
ANKMY1	51281	broad.mit.edu	37	2	241420440	241420440	+	Missense_Mutation	SNP	T	T	C			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	a53ffcc4-1471-4a5a-8f8a-1921eae48392	g.chr2:241420440T>C	ENST00000391987.1	-	17	3059	c.2693A>G	c.(2692-2694)tAc>tGc	p.Y898C	ANKMY1_ENST00000406958.1_Missense_Mutation_p.Y659C|ANKMY1_ENST00000373318.2_Missense_Mutation_p.Y677C|ANKMY1_ENST00000373320.4_Missense_Mutation_p.Y668C|ANKMY1_ENST00000272972.3_Missense_Mutation_p.Y898C|ANKMY1_ENST00000361678.4_Missense_Mutation_p.Y674C|ANKMY1_ENST00000403283.1_Missense_Mutation_p.Y800C|ANKMY1_ENST00000401804.1_Missense_Mutation_p.Y987C			Q9P2S6	ANKY1_HUMAN	ankyrin repeat and MYND domain containing 1	898							zinc ion binding			central_nervous_system(1)|endometrium(5)|large_intestine(4)|lung(14)|ovary(1)|prostate(2)|skin(1)|urinary_tract(2)	30		all_epithelial(40;2.79e-15)|Breast(86;2.41e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0335)|Lung NSC(271;0.106)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;1.03e-30)|all cancers(36;4.78e-28)|OV - Ovarian serous cystadenocarcinoma(60;1.45e-14)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;7.8e-06)|Lung(119;0.00271)|LUSC - Lung squamous cell carcinoma(224;0.01)|Colorectal(34;0.0101)|COAD - Colon adenocarcinoma(134;0.0476)		CAGGATCCCGTAGCAGCGAGG	0.617000													16	63					0	0	1	0	0
CUBN	8029	broad.mit.edu	37	10	17156057	17156057	+	Silent	SNP	T	T	C			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	a53ffcc4-1471-4a5a-8f8a-1921eae48392	g.chr10:17156057T>C	ENST00000377833.4	-	8	917	c.852A>G	c.(850-852)caA>caG	p.Q284Q		NM_001081.3	NP_001072.2	O60494	CUBN_HUMAN	cubilin (intrinsic factor-cobalamin receptor)	284	EGF-like 3; calcium-binding (Potential).				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			breast(8)|central_nervous_system(4)|cervix(1)|endometrium(18)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(42)|liver(1)|lung(107)|ovary(9)|pancreas(2)|prostate(3)|skin(9)|stomach(3)|upper_aerodigestive_tract(11)|urinary_tract(8)	241					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	AGAAAGAGCCTTGAGTGTTGA	0.562000													4	16					0	0	1	0	0
OR2M5	127059	broad.mit.edu	37	1	248308583	248308583	+	Missense_Mutation	SNP	T	T	C			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	a53ffcc4-1471-4a5a-8f8a-1921eae48392	g.chr1:248308583T>C	ENST00000366476.1	+	1	134	c.134T>C	c.(133-135)aTg>aCg	p.M45T		NM_001004690.1	NP_001004690.1	A3KFT3	OR2M5_HUMAN	olfactory receptor, family 2, subfamily M, member 5	45					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(5)|kidney(2)|large_intestine(7)|liver(1)|lung(25)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	49	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0388)			AACTCTGTCATGGTTCTCCTC	0.522000													183	230					0	0	1	0	0
IGKV6D-41	28869	broad.mit.edu	37	2	90108542	90108542	+	RNA	SNP	T	T	C			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	a53ffcc4-1471-4a5a-8f8a-1921eae48392	g.chr2:90108542T>C	ENST00000390271.2	+	0	39																											GGTGTCCCCGTTGCAATTCCT	0.408000													17	57					0	0	1	0	0
DNM1P46	196968	broad.mit.edu	37	15	100340069	100340069	+	RNA	SNP	C	C	A			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	a53ffcc4-1471-4a5a-8f8a-1921eae48392	g.chr15:100340069C>A	ENST00000341853.1	-	0	857					NR_003260.1																						TCCGCCGACTCCTGCAGGAGT	0.602000													7	11					0.27861	0.282897	1	1	0
PDGFRB	5159	broad.mit.edu	37	5	149515374	149515374	+	Silent	SNP	T	T	A			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	a53ffcc4-1471-4a5a-8f8a-1921eae48392	g.chr5:149515374T>A	ENST00000261799.4	-	3	577	c.108A>T	c.(106-108)acA>acT	p.T36T		NM_002609.3	NP_002600.1	P09619	PGFRB_HUMAN	platelet-derived growth factor receptor, beta polypeptide	36	Ig-like C2-type 1.				aorta morphogenesis|cardiac myofibril assembly|hemopoiesis|metanephric glomerular capillary formation|metanephric glomerular mesangial cell proliferation involved in metanephros development|peptidyl-tyrosine phosphorylation|positive regulation of calcium ion import|positive regulation of chemotaxis|positive regulation of DNA biosynthetic process|positive regulation of ERK1 and ERK2 cascade|positive regulation of MAP kinase activity|positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway|positive regulation of mitosis|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of reactive oxygen species metabolic process|positive regulation of smooth muscle cell migration|positive regulation of smooth muscle cell proliferation|protein autophosphorylation|regulation of actin cytoskeleton organization|retina vasculature development in camera-type eye|smooth muscle cell chemotaxis	apical plasma membrane|cytoplasm|integral to plasma membrane|nucleus	ATP binding|platelet activating factor receptor activity|platelet-derived growth factor beta-receptor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|vascular endothelial growth factor receptor activity			breast(3)|central_nervous_system(5)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(9)|kidney(3)|large_intestine(12)|lung(20)|ovary(3)|prostate(3)|skin(3)|stomach(6)|urinary_tract(1)	75		all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)		Becaplermin(DB00102)|Dasatinib(DB01254)|Imatinib(DB00619)|Sorafenib(DB00398)|Sunitinib(DB01268)	GCCCCGGGGGTGTGACGACCA	0.592000			T	"""ETV6, TRIP11, HIP1, RAB5EP, H4, NIN, HCMOGT-1, PDE4DIP"""	"""MPD, AML, CMML, CML"""								12	39					0	0	1	0	0
PCDHGA5	56110	broad.mit.edu	37	5	140746158	140746158	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	a53ffcc4-1471-4a5a-8f8a-1921eae48392	g.chr5:140746158C>A	ENST00000518069.1	+	1	2261	c.2261C>A	c.(2260-2262)tCc>tAc	p.S754Y	PCDHGB2_ENST00000522605.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGA2_ENST00000394576.2_Intron	NM_018918.2|NM_032054.1	NP_061741.1|NP_114443.1														endometrium(1)|kidney(1)|large_intestine(5)|lung(3)|ovary(5)|upper_aerodigestive_tract(3)	18			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CAGACCTATTCCCACGAGGTC	0.597000													50	187					5.57489e-27	9.19857e-27	1	1	0
XIRP2	129446	broad.mit.edu	37	2	168107683	168107683	+	Nonsense_Mutation	SNP	G	G	T			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	a53ffcc4-1471-4a5a-8f8a-1921eae48392	g.chr2:168107683G>T	ENST00000409195.1	+	9	9870	c.9781G>T	c.(9781-9783)Gaa>Taa	p.E3261*	XIRP2_ENST00000409043.1_Intron|XIRP2_ENST00000409756.2_Intron|XIRP2_ENST00000295237.9_Nonsense_Mutation_p.E3261*|XIRP2_ENST00000420519.1_Intron|XIRP2_ENST00000409273.1_Nonsense_Mutation_p.E3039*|XIRP2_ENST00000409728.1_Intron|XIRP2_ENST00000409605.1_Intron	NM_152381.5	NP_689594.4	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2	3086					actin cytoskeleton organization	cell junction	actin binding			NS(3)|biliary_tract(2)|breast(5)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(51)|lung(160)|ovary(7)|pancreas(3)|prostate(11)|skin(14)|stomach(5)|upper_aerodigestive_tract(8)|urinary_tract(7)	315						CGCTCAAGAGGAAATCAGGAA	0.423000													22	57					3.5997e-14	5.16479e-14	1	1	0
EEF2	1938	broad.mit.edu	37	19	3982008	3982008	+	Silent	SNP	G	G	T			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	a53ffcc4-1471-4a5a-8f8a-1921eae48392	g.chr19:3982008G>T	ENST00000309311.6	-	6	922	c.834C>A	c.(832-834)acC>acA	p.T278T		NM_001961.3	NP_001952.1	P13639	EF2_HUMAN	eukaryotic translation elongation factor 2	278						cytosol|ribonucleoprotein complex	GTP binding|GTPase activity|protein binding|translation elongation factor activity			endometrium(4)|large_intestine(4)|lung(6)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	21		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00461)|GBM - Glioblastoma multiforme(1328;0.0223)|STAD - Stomach adenocarcinoma(1328;0.18)		CTTCGGGGCTGGTGGCTGACT	0.607000													27	82					4.40665e-25	7.09362e-25	1	1	0
ZNF211	10520	broad.mit.edu	37	19	58152547	58152547	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	a53ffcc4-1471-4a5a-8f8a-1921eae48392	g.chr19:58152547G>T	ENST00000544273.1	+	5	1056	c.729G>T	c.(727-729)tgG>tgT	p.W243C	ZNF211_ENST00000347302.3_Missense_Mutation_p.W231C|ZNF211_ENST00000299871.5_Missense_Mutation_p.W296C|ZNF211_ENST00000391703.3_Missense_Mutation_p.W170C|ZNF211_ENST00000541801.1_Missense_Mutation_p.W222C|ZNF211_ENST00000240731.4_Missense_Mutation_p.W244C|ZNF211_ENST00000420680.1_Missense_Mutation_p.W235C|ZNF211_ENST00000254182.7_Missense_Mutation_p.W222C			Q13398	ZN211_HUMAN	zinc finger protein 211	231						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(8)|ovary(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	26		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		ATCACAACTGGGGAAAATGCA	0.448000													31	85					1.30897e-18	1.99366e-18	1	1	0
OR2L2	26246	broad.mit.edu	37	1	248201637	248201637	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	a53ffcc4-1471-4a5a-8f8a-1921eae48392	g.chr1:248201637G>T	ENST00000366479.2	+	1	164	c.68G>T	c.(67-69)gGc>gTc	p.G23V	OR2L13_ENST00000366478.2_Intron	NM_001004686.2	NP_001004686.1	Q8NH16	OR2L2_HUMAN	olfactory receptor, family 2, subfamily L, member 2	23					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(28)|ovary(1)|skin(4)|urinary_tract(1)	42	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0278)			TCAAGAATTGGCCTTTTCGTA	0.388000													45	185					9.84934e-19	1.52357e-18	1	1	0
ATP6V1C2	245973	broad.mit.edu	37	2	10922461	10922461	+	Missense_Mutation	SNP	T	T	A			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	a53ffcc4-1471-4a5a-8f8a-1921eae48392	g.chr2:10922461T>A	ENST00000381661.3	+	12	1125	c.1016T>A	c.(1015-1017)tTc>tAc	p.F339Y	ATP6V1C2_ENST00000272238.4_Missense_Mutation_p.F385Y	NM_144583.3	NP_653184.2	Q8NEY4	VATC2_HUMAN	ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C2	385					ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|insulin receptor signaling pathway|transferrin transport	cytosol|proton-transporting V-type ATPase, V1 domain				endometrium(2)|kidney(1)|large_intestine(3)|lung(8)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	19	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.191)			Epithelial(75;0.15)|OV - Ovarian serous cystadenocarcinoma(76;0.152)		AACTCTGTCTTCCGACATCTG	0.443000													15	56					0	0	1	0	0
FAIM2	23017	broad.mit.edu	37	12	50264295	50264295	+	Missense_Mutation	SNP	G	G	C			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	a53ffcc4-1471-4a5a-8f8a-1921eae48392	g.chr12:50264295G>C	ENST00000320634.3	-	12	1037	c.943C>G	c.(943-945)Cga>Gga	p.R315G	FAIM2_ENST00000550890.1_Missense_Mutation_p.R269G	NM_012306.3	NP_036438.2	Q9BWQ8	FAIM2_HUMAN	Fas apoptotic inhibitory molecule 2	315					anti-apoptosis|apoptosis	cell junction|integral to membrane|postsynaptic membrane				endometrium(2)|large_intestine(4)|lung(4)|ovary(2)|skin(2)	14						CCTCATTCTCGGTTAGTGCCA	0.537000													25	64					0	0	1	0	0
MYH7	4625	broad.mit.edu	37	14	23900847	23900847	+	Missense_Mutation	SNP	G	G	C			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	a53ffcc4-1471-4a5a-8f8a-1921eae48392	g.chr14:23900847G>C	ENST00000355349.3	-	8	841	c.679C>G	c.(679-681)Ctg>Gtg	p.L227V		NM_000257.2	NP_000248.2	P12883	MYH7_HUMAN	myosin, heavy chain 7, cardiac muscle, beta	227	Myosin head-like.		L -> V (in CMH1).		adult heart development|muscle filament sliding|regulation of heart rate|ventricular cardiac muscle tissue morphogenesis	focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(3)|breast(4)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(19)|lung(57)|ovary(5)|prostate(9)|skin(5)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(5)	137	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00725)		AAGGCCTCCAGAGCAGGGTTG	0.607000													34	124					0	0	1	0	0
SYT8	90019	broad.mit.edu	37	11	1857243	1857243	+	Missense_Mutation	SNP	G	G	A	rs907608	by1000genomes	TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	a53ffcc4-1471-4a5a-8f8a-1921eae48392	g.chr11:1857243G>A	ENST00000535046.1	+	4	842	c.842G>A	c.(841-843)cGg>cAg	p.R281Q	SYT8_ENST00000381968.3_Intron|SYT8_ENST00000483280.1_3'UTR|SYT8_ENST00000341958.3_Intron|SYT8_ENST00000436964.2_Missense_Mutation_p.R129Q			Q8NBV8	SYT8_HUMAN	synaptotagmin VIII	0	C2 2.					acrosomal vesicle|integral to membrane|plasma membrane|synaptic vesicle	transporter activity			breast(1)|large_intestine(1)|lung(2)|ovary(1)|skin(1)	6		all_epithelial(84;0.000138)|Breast(177;0.000962)|Ovarian(85;0.0014)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00136)|Lung(200;0.0681)|LUSC - Lung squamous cell carcinoma(625;0.082)		CAGGACCAGCGGTTCTGCGAG	0.682000													3	46					0	0	1	0	0
LILRA4	23547	broad.mit.edu	37	19	54848227	54848227	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	a53ffcc4-1471-4a5a-8f8a-1921eae48392	g.chr19:54848227G>T	ENST00000291759.4	-	6	1196	c.1140C>A	c.(1138-1140)ttC>ttA	p.F380L	AC008984.2_ENST00000507363.1_RNA	NM_012276.3	NP_036408.3	P59901	LIRA4_HUMAN	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 4	380	Ig-like C2-type 4.					integral to membrane	receptor activity			NS(2)|breast(1)|central_nervous_system(2)|endometrium(2)|large_intestine(5)|lung(13)|prostate(3)|skin(1)|upper_aerodigestive_tract(3)	32	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.0565)		GACTCATGGGGAATTCAGCCT	0.607000													47	141					5.2432e-18	7.8648e-18	1	1	0
TDRKH	11022	broad.mit.edu	37	1	151755442	151755442	+	Silent	SNP	C	C	A			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	a53ffcc4-1471-4a5a-8f8a-1921eae48392	g.chr1:151755442C>A	ENST00000368822.1	-	2	690	c.57G>T	c.(55-57)ctG>ctT	p.L19L	TDRKH_ENST00000368827.6_Silent_p.L19L|TDRKH_ENST00000484421.1_5'UTR|TDRKH_ENST00000368823.1_Silent_p.L19L|TDRKH_ENST00000368825.3_Silent_p.L19L|TDRKH_ENST00000368824.3_Silent_p.L19L|TDRKH_ENST00000440583.2_5'UTR|TDRKH_ENST00000458431.2_Silent_p.L19L			Q9Y2W6	TDRKH_HUMAN	tudor and KH domain containing	19							RNA binding			breast(5)|cervix(2)|endometrium(1)|kidney(1)|large_intestine(4)|lung(7)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	26	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.14)		LUSC - Lung squamous cell carcinoma(543;0.181)			TCCCAAGGCCCAGGGCTATTT	0.463000													39	130					6.57855e-14	9.30394e-14	1	1	0
PLEKHM1P	440456	broad.mit.edu	37	17	62820941	62820941	+	RNA	SNP	T	T	A			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	a53ffcc4-1471-4a5a-8f8a-1921eae48392	g.chr17:62820941T>A	ENST00000582986.1	-	0	188					NR_024386.1																						CAGGGACACGTACTGCTTTTG	0.532000													20	38					0	0	1	0	0
RLIM	51132	broad.mit.edu	37	X	73812447	73812447	+	Missense_Mutation	SNP	T	T	C			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	a53ffcc4-1471-4a5a-8f8a-1921eae48392	g.chrX:73812447T>C	ENST00000332687.6	-	4	921	c.703A>G	c.(703-705)Atg>Gtg	p.M235V	RLIM_ENST00000349225.2_Missense_Mutation_p.M235V	NM_016120.3	NP_057204.2	Q9NVW2	RNF12_HUMAN	ring finger protein, LIM domain interacting	235					random inactivation of X chromosome|transcription, DNA-dependent|ubiquitin-dependent protein catabolic process	cytoplasm|transcriptional repressor complex	transcription corepressor activity|ubiquitin-protein ligase activity|zinc ion binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(3)|lung(14)|ovary(2)|prostate(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	30						ATTTCACTCATTGGATGCAGA	0.498000													36	17					0	0	1	0	0
PTPRD	5789	broad.mit.edu	37	9	8484343	8484343	+	Silent	SNP	C	C	A			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	a53ffcc4-1471-4a5a-8f8a-1921eae48392	g.chr9:8484343C>A	ENST00000381196.4	-	27	3732	c.3189G>T	c.(3187-3189)gtG>gtT	p.V1063V	PTPRD_ENST00000355233.5_Silent_p.V652V|PTPRD_ENST00000540109.1_Silent_p.V1063V|PTPRD_ENST00000360074.4_Silent_p.V1050V|PTPRD_ENST00000537002.1_Silent_p.V649V|PTPRD_ENST00000358503.5_Silent_p.V1041V|PTPRD_ENST00000486161.1_Silent_p.V652V|PTPRD_ENST00000356435.5_Silent_p.V1063V|PTPRD_ENST00000397606.3_Silent_p.V642V|PTPRD_ENST00000397611.3_Silent_p.V649V|PTPRD_ENST00000397617.3_Silent_p.V642V	NM_002839.3	NP_002830.1	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	1063	Fibronectin type-III 8.				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(7)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|liver(1)|lung(83)|ovary(4)|pancreas(1)|prostate(7)|skin(19)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	168		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		CTCGGCCATCCACTTCTTCTA	0.378000										TSP Lung(15;0.13)			11	29					3.86212e-05	4.39483e-05	1	1	0
MAPK13	5603	broad.mit.edu	37	6	36104692	36104692	+	Missense_Mutation	SNP	T	T	C			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	a53ffcc4-1471-4a5a-8f8a-1921eae48392	g.chr6:36104692T>C	ENST00000211287.4	+	8	909	c.647T>C	c.(646-648)aTg>aCg	p.M216T	MAPK13_ENST00000373759.1_Intron|MAPK13_ENST00000373761.6_Missense_Mutation_p.M206T|MAPK13_ENST00000373766.5_Intron	NM_002754.4	NP_002745.1	O15264	MK13_HUMAN	mitogen-activated protein kinase 13	216	Protein kinase.				cell cycle|intracellular protein kinase cascade|nerve growth factor receptor signaling pathway|positive regulation of interleukin-6 production|Ras protein signal transduction|response to stress		ATP binding|MAP kinase activity|protein binding			breast(2)|central_nervous_system(1)|kidney(2)|large_intestine(2)|lung(2)|prostate(2)|skin(1)	12						ATGGCAGAGATGCTGACAGGG	0.507000													22	60					0	0	1	0	0
EVX2	344191	broad.mit.edu	37	2	176948244	176948244	+	Silent	SNP	G	G	T			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	a53ffcc4-1471-4a5a-8f8a-1921eae48392	g.chr2:176948244G>T	ENST00000308618.4	-	1	397	c.261C>A	c.(259-261)acC>acA	p.T87T		NM_001080458.1	NP_001073927.1	Q03828	EVX2_HUMAN	even-skipped homeobox 2	87						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			kidney(1)|large_intestine(3)|liver(1)|lung(8)|ovary(3)	16			OV - Ovarian serous cystadenocarcinoma(117;0.0207)|Epithelial(96;0.18)	READ - Rectum adenocarcinoma(9;0.0678)|Colorectal(32;0.115)		CGGAGGAGACGGTGCTTTCGC	0.627000													13	41					6.72482e-11	9.05793e-11	1	1	0
PPARA	5465	broad.mit.edu	37	22	46627756	46627756	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	a53ffcc4-1471-4a5a-8f8a-1921eae48392	g.chr22:46627756C>T	ENST00000396000.2	+	7	1044	c.779C>T	c.(778-780)gCc>gTc	p.A260V	PPARA_ENST00000402126.1_Missense_Mutation_p.A260V|PPARA_ENST00000262735.5_Missense_Mutation_p.A260V|PPARA_ENST00000434345.2_3'UTR|PPARA_ENST00000407236.1_Missense_Mutation_p.A260V			Q07869	PPARA_HUMAN	peroxisome proliferator-activated receptor alpha	260					fatty acid metabolic process|fatty acid transport|negative regulation of appetite|negative regulation of cholesterol storage|negative regulation of macrophage derived foam cell differentiation|negative regulation of receptor biosynthetic process|negative regulation of sequestering of triglyceride|negative regulation of transcription from RNA polymerase II promoter|positive regulation of fatty acid beta-oxidation|regulation of cellular ketone metabolic process by positive regulation of transcription from an RNA polymerase II promoter|regulation of glycolysis by positive regulation of transcription from an RNA polymerase II promoter|regulation of lipid transport by positive regulation of transcription from an RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	drug binding|ligand-regulated transcription factor activity|lipid binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|ubiquitin conjugating enzyme binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(5)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	15		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00522)	Atorvastatin(DB01076)|Bezafibrate(DB01393)|Clofibrate(DB00636)|Fenofibrate(DB01039)|Gemfibrozil(DB01241)|Simvastatin(DB00641)	AAGCTGGTGGCCAATGGCATC	0.552000													8	27					0	0	1	0	0
CHST14	113189	broad.mit.edu	37	15	40764364	40764364	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	a53ffcc4-1471-4a5a-8f8a-1921eae48392	g.chr15:40764364C>T	ENST00000306243.5	+	1	1205	c.952C>T	c.(952-954)Cac>Tac	p.H318Y	CHST14_ENST00000559991.1_Missense_Mutation_p.H293Y	NM_130468.3	NP_569735.1	Q8NCH0	CHSTE_HUMAN	carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 14	318					carbohydrate biosynthetic process|dermatan sulfate proteoglycan metabolic process	Golgi membrane|integral to membrane	N-acetylgalactosamine 4-O-sulfotransferase activity|phosphate binding			cervix(1)|large_intestine(1)|prostate(2)	4		all_cancers(109;2.34e-14)|all_epithelial(112;1.08e-11)|Lung NSC(122;2.95e-09)|all_lung(180;6.03e-08)|Melanoma(134;0.091)|Colorectal(260;0.198)|Ovarian(310;0.243)		GBM - Glioblastoma multiforme(113;3e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0781)		GGCACCACCTCACGTCCGATT	0.627000													22	59					0	0	1	0	0
PRX	57716	broad.mit.edu	37	19	40902282	40902282	+	Silent	SNP	G	G	A			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	a53ffcc4-1471-4a5a-8f8a-1921eae48392	g.chr19:40902282G>A	ENST00000324001.7	-	7	2247	c.1977C>T	c.(1975-1977)ctC>ctT	p.L659L	PRX_ENST00000291825.7_3'UTR	NM_181882.2	NP_870998.2	Q9BXM0	PRAX_HUMAN	periaxin	659	55 X 5 AA approximate tandem repeats of [LVMAG]-[PSREQC]-[EDKL]-[LIVMAP]- [AQKHRPE]; that may have a tripeptide spacer of [LV]-P-[KER].				axon ensheathment	cytoplasm|nucleus|plasma membrane	protein binding			breast(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(7)|lung(12)|ovary(2)|prostate(3)|skin(1)|urinary_tract(9)	47			Lung(22;6.24e-05)|LUSC - Lung squamous cell carcinoma(20;0.000384)			GGACTTTCGGGAGCTGCACTT	0.562000													6	177					0	0	1	0	0
OR4N2	390429	broad.mit.edu	37	14	20296223	20296223	+	Missense_Mutation	SNP	A	A	G	rs79084933		TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	a53ffcc4-1471-4a5a-8f8a-1921eae48392	g.chr14:20296223A>G	ENST00000315947.1	+	1	616	c.616A>G	c.(616-618)Atg>Gtg	p.M206V	OR4N2_ENST00000568211.1_3'UTR	NM_001004723.1	NP_001004723.1	Q8NGD1	OR4N2_HUMAN	olfactory receptor, family 4, subfamily N, member 2	206					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|liver(1)|lung(32)|ovary(2)|prostate(1)|skin(2)|stomach(2)	52	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		CAGTGGCCTGATGACACTCCT	0.522000													36	161					0	0	1	0	0
COL4A4	1286	broad.mit.edu	37	2	227896701	227896701	+	Silent	SNP	T	T	A			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	a53ffcc4-1471-4a5a-8f8a-1921eae48392	g.chr2:227896701T>A	ENST00000396625.3	-	40	3984	c.3777A>T	c.(3775-3777)ccA>ccT	p.P1259P	COL4A4_ENST00000329662.7_Silent_p.P1259P	NM_000092.4	NP_000083.3	P53420	CO4A4_HUMAN	collagen, type IV, alpha 4	1259	Triple-helical region.				axon guidance|glomerular basement membrane development	basal lamina|collagen type IV	extracellular matrix structural constituent|protein binding			breast(2)|central_nervous_system(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(15)|lung(35)|ovary(5)|pancreas(3)|prostate(2)|skin(12)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	98		Renal(207;0.00844)|all_lung(227;0.0187)|Lung NSC(271;0.0879)|all_hematologic(139;0.21)|Esophageal squamous(248;0.242)		Epithelial(121;6.7e-11)|all cancers(144;5.39e-08)|Lung(261;0.0132)|LUSC - Lung squamous cell carcinoma(224;0.0181)		GATCTCCAGGTGGACCCGGGT	0.537000													9	25					0	0	1	0	0
CRISP3	10321	broad.mit.edu	37	6	49704130	49704130	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	a53ffcc4-1471-4a5a-8f8a-1921eae48392	g.chr6:49704130G>T	ENST00000433368.2	-	3	301	c.232C>A	c.(232-234)Ccc>Acc	p.P78T	CRISP3_ENST00000371159.4_Missense_Mutation_p.P86T|CRISP3_ENST00000393666.1_Missense_Mutation_p.P55T|CRISP3_ENST00000423399.2_Intron|CRISP3_ENST00000263045.4_Missense_Mutation_p.P68T	NM_001190986.1	NP_001177915.1	P54108	CRIS3_HUMAN	cysteine-rich secretory protein 3	55					innate immune response	proteinaceous extracellular matrix|specific granule				breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(14)|skin(6)|upper_aerodigestive_tract(1)	27	Lung NSC(77;0.0161)		KIRC - Kidney renal clear cell carcinoma(2;0.106)|Kidney(12;0.156)			CTGGCAGGGGGAGATACTGCT	0.468000													50	117					2.81731e-22	4.39234e-22	1	1	0
NBEA	26960	broad.mit.edu	37	13	36167537	36167537	+	Translation_Start_Site	SNP	G	G	A	rs116439886	by1000genomes	TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	a53ffcc4-1471-4a5a-8f8a-1921eae48392	g.chr13:36167537G>A	ENST00000379922.3	+	0	395				NBEA_ENST00000540320.1_Missense_Mutation_p.V2417I|NBEA_ENST00000537702.1_Missense_Mutation_p.V210I|NBEA_ENST00000379939.2_Missense_Mutation_p.V2414I|NBEA_ENST00000310336.4_Missense_Mutation_p.V2417I|NBEA_ENST00000400445.3_Missense_Mutation_p.V2417I			Q8NFP9	NBEA_HUMAN	neurobeachin							cytosol|endomembrane system|plasma membrane|trans-Golgi network	protein binding			NS(1)|breast(1)|endometrium(14)|kidney(4)|large_intestine(29)|lung(40)|ovary(9)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	108		Breast(139;0.0141)|Lung SC(185;0.0548)|Prostate(109;0.207)		all cancers(112;1.93e-08)|Epithelial(112;1.62e-07)|BRCA - Breast invasive adenocarcinoma(63;0.00033)|OV - Ovarian serous cystadenocarcinoma(117;0.00109)|KIRC - Kidney renal clear cell carcinoma(186;0.00575)|Kidney(163;0.00656)|GBM - Glioblastoma multiforme(144;0.191)|Lung(94;0.199)		CTTCTCATCCGTTGCAAGGTC	0.338000													17	67					0	0	1	0	0
IGHV1-2	28474	broad.mit.edu	37	14	106452746	106452746	+	RNA	SNP	G	G	T			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	a53ffcc4-1471-4a5a-8f8a-1921eae48392	g.chr14:106452746G>T	ENST00000390594.2	-	0	339																											TGATGGACGTGTCCCTGGTCA	0.547000													60	98					1.73933e-33	2.96885e-33	1	1	0
H2AFY	9555	broad.mit.edu	37	5	134679002	134679002	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	a53ffcc4-1471-4a5a-8f8a-1921eae48392	g.chr5:134679002C>A	ENST00000511689.1	-	8	1494	c.901G>T	c.(901-903)Gct>Tct	p.A301S	H2AFY_ENST00000312469.4_Missense_Mutation_p.A298S|H2AFY_ENST00000510038.1_Missense_Mutation_p.A301S|H2AFY_ENST00000423969.2_Missense_Mutation_p.A129S|H2AFY_ENST00000512507.1_5'UTR|CTC-203F4.1_ENST00000555438.1_Intron|CTC-203F4.1_ENST00000432382.3_Missense_Mutation_p.A95D|H2AFY_ENST00000304332.4_Missense_Mutation_p.A300S	NM_001040158.1|NM_138610.2	NP_001035248.1|NP_613258.2	O75367	H2AY_HUMAN	H2A histone family, member Y	301	Macro.				chromatin modification|dosage compensation|nucleosome assembly	Barr body|nucleosome	DNA binding			endometrium(3)|large_intestine(3)|lung(3)|ovary(1)|urinary_tract(1)	11			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			TTATCATCAGCCAGGGCCAAG	0.498000													70	89					5.45122e-27	9.0701e-27	1	1	0
NNT	23530	broad.mit.edu	37	5	43616166	43616166	+	Splice_Site	SNP	G	G	T			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	a53ffcc4-1471-4a5a-8f8a-1921eae48392	g.chr5:43616166G>T	ENST00000264663.5	+	4	819	c.599_splice	c.e4+1	p.G200_splice	NNT_ENST00000344920.4_Splice_Site_p.G200_splice|NNT_ENST00000512996.2_Splice_Site_p.G69_splice	NM_012343.3	NP_036475.3	Q13423	NNTM_HUMAN	nicotinamide nucleotide transhydrogenase	200					tricarboxylic acid cycle	integral to membrane|mitochondrial respiratory chain	NAD binding|NAD(P)+ transhydrogenase (AB-specific) activity|NAD(P)+ transhydrogenase (B-specific) activity|NADP binding			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(7)|large_intestine(6)|liver(2)|lung(20)|ovary(3)|prostate(2)|skin(1)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	51	Lung NSC(6;2.58e-06)				NADH(DB00157)	CAACATTGCGGGGTAGGTTCT	0.413000													27	72					4.87955e-14	6.95073e-14	1	1	0
PRUNE2	158471	broad.mit.edu	37	9	79325166	79325166	+	Missense_Mutation	SNP	T	T	C			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	a53ffcc4-1471-4a5a-8f8a-1921eae48392	g.chr9:79325166T>C	ENST00000428286.1	-	8	2147	c.947A>G	c.(946-948)gAa>gGa	p.E316G	PRUNE2_ENST00000376718.3_Missense_Mutation_p.E675G			Q8WUY3	PRUN2_HUMAN	prune homolog 2 (Drosophila)	675					apoptosis|G1 phase|induction of apoptosis	cytoplasm	metal ion binding|pyrophosphatase activity			endometrium(1)|kidney(4)|large_intestine(3)|lung(7)|prostate(1)	16						AGATTCCTGTTCACTGGAACT	0.498000													15	42					0	0	1	0	0
VAV1	7409	broad.mit.edu	37	19	6772930	6772930	+	Silent	SNP	C	C	A			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	a53ffcc4-1471-4a5a-8f8a-1921eae48392	g.chr19:6772930C>A	ENST00000304076.2	+	1	206	c.112C>A	c.(112-114)Cgg>Agg	p.R38R	VAV1_ENST00000602142.1_Silent_p.R38R|VAV1_ENST00000596764.1_Silent_p.R38R	NM_001258206.1	NP_001245135.1	P15498	VAV_HUMAN	vav 1 guanine nucleotide exchange factor	38	CH.|Leu-rich.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|platelet activation|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|T cell costimulation	cytosol|plasma membrane	metal ion binding|protein binding|sequence-specific DNA binding transcription factor activity			biliary_tract(1)|breast(3)|central_nervous_system(2)|endometrium(3)|kidney(5)|large_intestine(16)|lung(18)|ovary(5)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)	62						CCAGGCCCTCCGGGATGGTGT	0.652000													19	70					4.96729e-08	6.22483e-08	1	1	0
ZNF804A	91752	broad.mit.edu	37	2	185801843	185801843	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	a53ffcc4-1471-4a5a-8f8a-1921eae48392	g.chr2:185801843G>T	ENST00000302277.6	+	4	2314	c.1720G>T	c.(1720-1722)Gat>Tat	p.D574Y		NM_194250.1	NP_919226.1	Q7Z570	Z804A_HUMAN	zinc finger protein 804A	574						intracellular	zinc ion binding	p.D574Y(1)		NS(5)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(22)|liver(2)|lung(79)|ovary(7)|pancreas(1)|prostate(2)|skin(12)|urinary_tract(1)	146						GGACACTCTAGATGAAAAATA	0.299000													15	45					3.41278e-10	4.4456e-10	1	1	0
HKDC1	80201	broad.mit.edu	37	10	71026381	71026381	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	a53ffcc4-1471-4a5a-8f8a-1921eae48392	g.chr10:71026381G>T	ENST00000354624.5	+	18	2755	c.2622G>T	c.(2620-2622)ttG>ttT	p.L874F	RP11-227H15.5_ENST00000413220.1_RNA	NM_025130.3	NP_079406.3	Q2TB90	HKDC1_HUMAN	hexokinase domain containing 1	874					glycolysis	mitochondrion|nucleus	ATP binding|hexokinase activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(11)|ovary(5)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	34						CTAGAATATTGCAGGAAACTG	0.403000													25	88					7.01153e-11	9.3803e-11	1	1	0
FAT2	2196	broad.mit.edu	37	5	150947209	150947209	+	Silent	SNP	G	G	A			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	a53ffcc4-1471-4a5a-8f8a-1921eae48392	g.chr5:150947209G>A	ENST00000261800.5	-	1	1296	c.1284C>T	c.(1282-1284)caC>caT	p.H428H		NM_001447.2	NP_001438.1	Q9NYQ8	FAT2_HUMAN	FAT atypical cadherin 2	428	Cadherin 3.				epithelial cell migration|homophilic cell adhesion	cell-cell adherens junction|integral to membrane|nucleus	calcium ion binding			NS(6)|breast(3)|central_nervous_system(3)|cervix(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(61)|liver(1)|lung(60)|ovary(6)|prostate(5)|skin(5)|stomach(2)|upper_aerodigestive_tract(11)|urinary_tract(1)	196		Medulloblastoma(196;0.0912)|all_hematologic(541;0.104)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			GTAGCTGATAGTGGGCTCTGT	0.498000													39	124					0	0	1	0	0
OAS1	4938	broad.mit.edu	37	12	113357335	113357335	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	a53ffcc4-1471-4a5a-8f8a-1921eae48392	g.chr12:113357335G>A	ENST00000202917.5	+	6	1443	c.1180G>A	c.(1180-1182)Gac>Aac	p.D394N	OAS1_ENST00000445409.2_Missense_Mutation_p.G361E|RP1-71H24.1_ENST00000552784.1_RNA|OAS1_ENST00000551241.1_Intron	NM_016816.2	NP_058132.2	P00973	OAS1_HUMAN	2'-5'-oligoadenylate synthetase 1, 40/46kDa	394					interferon-gamma-mediated signaling pathway|nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|type I interferon-mediated signaling pathway	endoplasmic reticulum|microsome|mitochondrion|nucleus	ATP binding|nucleotidyltransferase activity|RNA binding			cervix(1)|endometrium(3)|kidney(1)|large_intestine(2)|liver(2)|lung(4)|ovary(2)|skin(1)	16						GGCAGAAGAGGACTGGACCTG	0.507000													14	69					0	0	1	0	0
TEX35	84066	broad.mit.edu	37	1	178485002	178485002	+	Silent	SNP	C	C	G			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	a53ffcc4-1471-4a5a-8f8a-1921eae48392	g.chr1:178485002C>G	ENST00000367641.3	+	4	227	c.168C>G	c.(166-168)ctC>ctG	p.L56L	TEX35_ENST00000319416.2_Silent_p.L56L|TEX35_ENST00000258298.2_5'UTR|TEX35_ENST00000367643.3_Silent_p.L56L|TEX35_ENST00000367642.3_Intron|TEX35_ENST00000367639.1_Silent_p.L64L					testis expressed 35																		AGAATGAACTCAGGGAAGTGA	0.433000													12	24					0	0	1	0	0
GLI3	2737	broad.mit.edu	37	7	42063167	42063167	+	Missense_Mutation	SNP	T	T	C			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	a53ffcc4-1471-4a5a-8f8a-1921eae48392	g.chr7:42063167T>C	ENST00000395925.3	-	10	1481	c.1397A>G	c.(1396-1398)gAc>gGc	p.D466G	GLI3_ENST00000479210.1_5'UTR	NM_000168.5	NP_000159.3	P10071	GLI3_HUMAN	GLI family zinc finger 3	466					negative regulation of alpha-beta T cell differentiation|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of smoothened signaling pathway|negative regulation of transcription from RNA polymerase II promoter|negative thymic T cell selection|positive regulation of alpha-beta T cell differentiation|positive regulation of transcription from RNA polymerase II promoter|thymocyte apoptosis	cilium|cytosol|nucleolus	beta-catenin binding|histone acetyltransferase binding|histone deacetylase binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(2)|biliary_tract(1)|breast(4)|central_nervous_system(2)|endometrium(12)|kidney(7)|large_intestine(25)|lung(49)|ovary(3)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	112						TTCATCTTTGTCCCCTTCCTC	0.542000									Pallister-Hall syndrome;Greig Cephalopolysyndactyly				15	68					0	0	1	0	0
PCDHB14	56122	broad.mit.edu	37	5	140604499	140604499	+	Missense_Mutation	SNP	C	C	G			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	a53ffcc4-1471-4a5a-8f8a-1921eae48392	g.chr5:140604499C>G	ENST00000239449.4	+	1	1422	c.1422C>G	c.(1420-1422)agC>agG	p.S474R	PCDHB14_ENST00000515856.2_Missense_Mutation_p.S321R	NM_018934.2	NP_061757.1	Q9Y5E9	PCDBE_HUMAN		474	Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(21)|ovary(2)|prostate(3)|skin(6)|urinary_tract(1)	49			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GCAGCGTCAGCGCCACAGACA	0.637000													99	194					0	0	1	0	0
OR51G2	81282	broad.mit.edu	37	11	4936874	4936874	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	a53ffcc4-1471-4a5a-8f8a-1921eae48392	g.chr11:4936874C>A	ENST00000322013.3	-	1	48	c.20G>T	c.(19-21)gGa>gTa	p.G7V	MMP26_ENST00000477339.1_Intron|MMP26_ENST00000380390.1_Intron	NM_001005238.1	NP_001005238.1	Q8NGK0	O51G2_HUMAN	olfactory receptor, family 51, subfamily G, member 2	7					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			autonomic_ganglia(1)|endometrium(1)|large_intestine(9)|lung(12)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;5.06e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00438)|LUSC - Lung squamous cell carcinoma(625;0.19)		GCTGCTGTTTCCCAGGGATCC	0.547000													18	43					5.3912e-06	6.27917e-06	1	1	0
FRMPD1	22844	broad.mit.edu	37	9	37745408	37745408	+	Nonsense_Mutation	SNP	G	G	T			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	a53ffcc4-1471-4a5a-8f8a-1921eae48392	g.chr9:37745408G>T	ENST00000539465.1	+	16	3972	c.3379G>T	c.(3379-3381)Gag>Tag	p.E1127*	RP11-613M10.9_ENST00000540557.1_Intron|FRMPD1_ENST00000377765.3_Nonsense_Mutation_p.E1127*			Q5SYB0	FRPD1_HUMAN	FERM and PDZ domain containing 1	1127						cytoskeleton|cytosol|plasma membrane				NS(3)|breast(2)|central_nervous_system(2)|endometrium(5)|kidney(4)|large_intestine(22)|lung(34)|ovary(5)|prostate(3)|skin(8)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	93				GBM - Glioblastoma multiforme(29;0.00655)		CGTATTTCAGGAGGAGTCTAG	0.428000													14	53					1.3612e-06	1.6434e-06	1	1	0
SPTA1	6708	broad.mit.edu	37	1	158623075	158623075	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	a53ffcc4-1471-4a5a-8f8a-1921eae48392	g.chr1:158623075C>A	ENST00000368148.3	-	22	3357	c.3177G>T	c.(3175-3177)caG>caT	p.Q1059H	SPTA1_ENST00000368147.3_Missense_Mutation_p.Q1059H	NM_003126.2	NP_003117.2	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1 (elliptocytosis 2)	1059					actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			NS(3)|breast(7)|cervix(1)|endometrium(22)|kidney(9)|large_intestine(29)|liver(2)|lung(183)|ovary(5)|prostate(18)|skin(11)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(6)	307	all_hematologic(112;0.0378)					GGTTCTCAATCTGCTCCTGGC	0.517000													34	160					6.04917e-29	1.01503e-28	1	1	0
ATP13A4	84239	broad.mit.edu	37	3	193210752	193210752	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	a53ffcc4-1471-4a5a-8f8a-1921eae48392	g.chr3:193210752G>T	ENST00000342695.4	-	5	809	c.487C>A	c.(487-489)Cat>Aat	p.H163N	ATP13A4_ENST00000295548.3_Missense_Mutation_p.H163N|ATP13A4_ENST00000392443.3_Missense_Mutation_p.H163N	NM_032279.2	NP_115655.2	Q4VNC1	AT134_HUMAN	ATPase type 13A4	163					ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(9)|lung(27)|ovary(2)|prostate(3)|skin(11)|upper_aerodigestive_tract(2)	71	all_cancers(143;1.76e-08)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(49;2.72e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;0.000109)		AATTTTTGATGTATCTTGGCA	0.308000													7	38					8.12818e-05	9.14421e-05	1	1	0
GRB10	2887	broad.mit.edu	37	7	50694650	50694650	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	a53ffcc4-1471-4a5a-8f8a-1921eae48392	g.chr7:50694650C>T	ENST00000403097.1	-	7	1292	c.512G>A	c.(511-513)gGg>gAg	p.G171E	GRB10_ENST00000398810.2_Missense_Mutation_p.G119E|GRB10_ENST00000401949.1_Missense_Mutation_p.G177E|GRB10_ENST00000402497.1_Missense_Mutation_p.G119E|GRB10_ENST00000439599.1_Missense_Mutation_p.G171E|GRB10_ENST00000402578.1_Missense_Mutation_p.G119E|GRB10_ENST00000406641.1_Missense_Mutation_p.G119E|GRB10_ENST00000357271.5_Missense_Mutation_p.G177E|GRB10_ENST00000398812.2_Missense_Mutation_p.G177E|GRB10_ENST00000335866.3_Missense_Mutation_p.G119E|GRB10_ENST00000407526.1_Missense_Mutation_p.G119E			Q13322	GRB10_HUMAN	growth factor receptor-bound protein 10	177	Ras-associating.				insulin receptor signaling pathway|negative regulation of glucose import|negative regulation of glycogen biosynthetic process|negative regulation of insulin receptor signaling pathway|negative regulation of Wnt receptor signaling pathway|positive regulation of phosphorylation|positive regulation of vascular endothelial growth factor receptor signaling pathway	cytosol|plasma membrane	insulin receptor binding|SH3/SH2 adaptor activity			NS(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(2)|lung(19)|ovary(3)|skin(3)|upper_aerodigestive_tract(2)	41	Glioma(55;0.08)|all_neural(89;0.245)					TTTGCTTGTCCCATCTTCACT	0.413000									Russell-Silver syndrome				60	181					0	0	1	0	0
USP47	55031	broad.mit.edu	37	11	11964407	11964407	+	Missense_Mutation	SNP	A	A	T			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	a53ffcc4-1471-4a5a-8f8a-1921eae48392	g.chr11:11964407A>T	ENST00000339865.5	+	19	3398	c.2635A>T	c.(2635-2637)Agc>Tgc	p.S879C	USP47_ENST00000399455.2_Missense_Mutation_p.S967C|USP47_ENST00000527733.1_Missense_Mutation_p.S947C|USP47_ENST00000539466.1_5'UTR	NM_017944.3	NP_060414.3	Q96K76	UBP47_HUMAN	ubiquitin specific peptidase 47	967					base-excision repair|cellular response to UV|monoubiquitinated protein deubiquitination|negative regulation of apoptosis|negative regulation of caspase activity|negative regulation of G2/M transition of mitotic cell cycle|negative regulation of transcription, DNA-dependent|positive regulation of cell growth|response to drug|ubiquitin-dependent protein catabolic process	cytoplasm|SCF ubiquitin ligase complex	ubiquitin thiolesterase activity|ubiquitin-specific protease activity|WD40-repeat domain binding			breast(4)|endometrium(7)|kidney(2)|large_intestine(8)|liver(2)|lung(14)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	46				Epithelial(150;0.000339)		CTCCAGTCATAGCAGTGATAC	0.403000													27	91					0	0	1	0	0
ALKBH2	121642	broad.mit.edu	37	12	109530431	109530431	+	Missense_Mutation	SNP	C	C	G			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	a53ffcc4-1471-4a5a-8f8a-1921eae48392	g.chr12:109530431C>G	ENST00000429722.2	-	2	524	c.161G>C	c.(160-162)gGc>gCc	p.G54A	ALKBH2_ENST00000343075.3_Missense_Mutation_p.G54A|ALKBH2_ENST00000440112.2_Missense_Mutation_p.G54A	NM_001145374.1	NP_001138846.1	Q6NS38	ALKB2_HUMAN	alkB, alkylation repair homolog 2 (E. coli)	54					DNA dealkylation involved in DNA repair|oxidative DNA demethylation	nucleoplasm	cytosine C-5 DNA demethylase activity|damaged DNA binding|DNA-N1-methyladenine dioxygenase activity|ferrous iron binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			endometrium(1)|kidney(3)|large_intestine(1)|lung(3)	8					Vitamin C(DB00126)	CCAGCTAGGGCCTGCTGAGTG	0.567000								Direct reversal of damage					30	114					0	0	1	0	0
THNSL2	55258	broad.mit.edu	37	2	88484880	88484880	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	a53ffcc4-1471-4a5a-8f8a-1921eae48392	g.chr2:88484880G>T	ENST00000324166.5	+	7	2802	c.1111G>T	c.(1111-1113)Gat>Tat	p.D371Y	THNSL2_ENST00000496844.1_Intron|THNSL2_ENST00000377254.3_Intron|THNSL2_ENST00000358591.2_Missense_Mutation_p.D371Y|THNSL2_ENST00000449349.1_Intron|THNSL2_ENST00000343544.4_Intron|THNSL2_ENST00000402102.1_Intron	NM_018271.4	NP_060741.3	Q86YJ6	THNS2_HUMAN	threonine synthase-like 2 (S. cerevisiae)	371					threonine biosynthetic process		threonine synthase activity			breast(4)|lung(17)|ovary(1)|prostate(3)|upper_aerodigestive_tract(2)	27						GTCAGTGTCGGATGAAGCCAT	0.567000													15	36					2.48551e-13	3.49028e-13	1	1	0
SBK1	388228	broad.mit.edu	37	16	28330438	28330438	+	Missense_Mutation	SNP	G	G	C			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	a53ffcc4-1471-4a5a-8f8a-1921eae48392	g.chr16:28330438G>C	ENST00000341901.4	+	3	1138	c.349G>C	c.(349-351)Gtc>Ctc	p.V117L		NM_001024401.2	NP_001019572.1	Q52WX2	SBK1_HUMAN	SH3 domain binding kinase 1	117	Protein kinase.					cytoplasm	ATP binding|protein serine/threonine kinase activity			kidney(1)|lung(3)|ovary(1)	5						CTTTGACGTGGTCTTTGAGAC	0.537000													21	80					0	0	1	0	0
KLF12	11278	broad.mit.edu	37	13	74387411	74387411	+	Silent	SNP	G	G	A			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	a53ffcc4-1471-4a5a-8f8a-1921eae48392	g.chr13:74387411G>A	ENST00000377669.2	-	4	710	c.684C>T	c.(682-684)ccC>ccT	p.P228P	KLF12_ENST00000377666.4_Silent_p.P228P|KLF12_ENST00000472022.1_5'UTR	NM_007249.4	NP_009180.3	Q9Y4X4	KLF12_HUMAN	Kruppel-like factor 12	228					negative regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			central_nervous_system(1)|endometrium(5)|large_intestine(2)|lung(6)|ovary(1)|skin(1)	16		Prostate(6;0.00217)|Breast(118;0.0838)		GBM - Glioblastoma multiforme(99;0.00677)		ATAGGCCTCGGGGGTCCATTT	0.428000													40	83					0	0	1	0	0
KMT2C	58508	broad.mit.edu	37	7	151874411	151874411	+	Silent	SNP	G	G	A			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	a53ffcc4-1471-4a5a-8f8a-1921eae48392	g.chr7:151874411G>A	ENST00000355193.2	-	38	8345	c.8127C>T	c.(8125-8127)gtC>gtT	p.V2709V	KMT2C_ENST00000262189.6_Silent_p.V2709V					lysine (K)-specific methyltransferase 2C																		CTAAGTCTTTGACTTCAACCC	0.378000													23	72					0	0	1	0	0
PSMD6	9861	broad.mit.edu	37	3	64004295	64004295	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	a53ffcc4-1471-4a5a-8f8a-1921eae48392	g.chr3:64004295G>A	ENST00000492933.1	-	6	1017	c.965C>T	c.(964-966)tCt>tTt	p.S322F	PSMD6_ENST00000295901.4_Missense_Mutation_p.S269F|PSMD6_ENST00000482510.1_Missense_Mutation_p.S230F|PSMD6_ENST00000394431.2_Missense_Mutation_p.S231F	NM_001271779.1	NP_001258708.1	Q15008	PSMD6_HUMAN	proteasome (prosome, macropain) 26S subunit, non-ATPase, 6	269	PCI.				anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	proteasome complex	ATPase activity|protein binding			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(2)|pancreas(1)|prostate(1)|skin(1)	13		Lung NSC(201;0.136)		BRCA - Breast invasive adenocarcinoma(55;0.000805)|Kidney(15;0.00188)|KIRC - Kidney renal clear cell carcinoma(15;0.00212)		GAAGAAAACAGAGTAACGGCA	0.373000													12	25					0	0	1	0	0
DNAH7	56171	broad.mit.edu	37	2	196689076	196689076	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	a53ffcc4-1471-4a5a-8f8a-1921eae48392	g.chr2:196689076C>A	ENST00000312428.6	-	49	9294	c.9194G>T	c.(9193-9195)cGg>cTg	p.R3065L		NM_018897.2	NP_061720.2	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	3065	AAA 5 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(4)|breast(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(28)|liver(3)|lung(100)|ovary(4)|prostate(5)|skin(26)|upper_aerodigestive_tract(2)|urinary_tract(3)	205						GTCCCCAAGCCGGATACATGT	0.413000													25	83					3.96558e-24	6.33214e-24	1	1	0
IL31RA	133396	broad.mit.edu	37	5	55164699	55164699	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	a53ffcc4-1471-4a5a-8f8a-1921eae48392	g.chr5:55164699G>A	ENST00000396834.1	+	5	674	c.178G>A	c.(178-180)Gaa>Aaa	p.E60K	IL31RA_ENST00000447346.2_Missense_Mutation_p.E79K|IL31RA_ENST00000396836.2_Missense_Mutation_p.E79K|IL31RA_ENST00000490985.1_5'UTR|IL31RA_ENST00000354961.4_Missense_Mutation_p.E60K|IL31RA_ENST00000359040.5_Missense_Mutation_p.E79K|IL31RA_ENST00000297015.3_Intron	NM_001242638.1	NP_001229567.1	Q8NI17	IL31R_HUMAN	interleukin 31 receptor A	47	Fibronectin type-III 1.				anti-apoptosis|defense response|homeostatic process|JAK-STAT cascade|macrophage differentiation|MAPKKK cascade|monocyte differentiation|negative regulation of macrophage activation|positive regulation of cell proliferation|positive regulation of transcription, DNA-dependent|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of tyrosine phosphorylation of Stat5 protein|transmembrane receptor protein tyrosine kinase signaling pathway	integral to membrane|plasma membrane	cytokine receptor activity|protein kinase binding|transcription coactivator activity			endometrium(2)|kidney(2)|large_intestine(7)|lung(8)|ovary(1)|stomach(1)	21		Lung NSC(810;6.93e-05)|Prostate(74;0.00741)|Breast(144;0.0544)|Ovarian(174;0.223)				TCCAGGAAAGGAAACCAGTTA	0.418000													41	124					0	0	1	0	0
UGT2B4	7363	broad.mit.edu	37	4	70351130	70351130	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	a53ffcc4-1471-4a5a-8f8a-1921eae48392	g.chr4:70351130C>A	ENST00000305107.6	-	5	1152	c.1106G>T	c.(1105-1107)aGa>aTa	p.R369I	UGT2B4_ENST00000381096.3_Missense_Mutation_p.R233I|UGT2B4_ENST00000512583.1_Intron|UGT2B4_ENST00000506580.1_Intron	NM_021139.2	NP_066962.2	P06133	UD2B4_HUMAN	UDP glucuronosyltransferase 2 family, polypeptide B4	369					estrogen catabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(29)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	47						TATAAAAGCTCTGGTTTTTGG	0.398000													50	155					2.55665e-31	4.32663e-31	1	1	0
MAZ	4150	broad.mit.edu	37	16	29821464	29821464	+	Missense_Mutation	SNP	T	T	C			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	a53ffcc4-1471-4a5a-8f8a-1921eae48392	g.chr16:29821464T>C	ENST00000322945.6	+	5	1511	c.1346T>C	c.(1345-1347)gTa>gCa	p.V449A	AC009133.20_ENST00000569039.1_RNA|MAZ_ENST00000568544.1_Missense_Mutation_p.V50A|MAZ_ENST00000562337.1_Missense_Mutation_p.V144A|MAZ_ENST00000568282.1_3'UTR|MAZ_ENST00000219782.6_3'UTR|MAZ_ENST00000566906.2_Silent_p.S103S|MAZ_ENST00000545521.1_Missense_Mutation_p.V426A|MAZ_ENST00000563402.1_Silent_p.S105S|AC009133.14_ENST00000569981.1_RNA	NM_002383.2	NP_002374.2	P56270	MAZ_HUMAN	MYC-associated zinc finger protein (purine-binding transcription factor)	449	Poly-Ala.				regulation of transcription, DNA-dependent|termination of RNA polymerase II transcription|transcription initiation from RNA polymerase II promoter	nucleus	DNA binding|protein binding|RNA binding|zinc ion binding			endometrium(3)|lung(4)|ovary(2)|upper_aerodigestive_tract(1)	10						gcggcagcagtagcagcCCCT	0.672000													6	13					0	0	1	0	0
XIRP2	129446	broad.mit.edu	37	2	168100016	168100016	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	a53ffcc4-1471-4a5a-8f8a-1921eae48392	g.chr2:168100016G>T	ENST00000409195.1	+	9	2203	c.2114G>T	c.(2113-2115)gGa>gTa	p.G705V	XIRP2_ENST00000409043.1_Intron|XIRP2_ENST00000409756.2_Intron|XIRP2_ENST00000295237.9_Missense_Mutation_p.G705V|XIRP2_ENST00000420519.1_Intron|XIRP2_ENST00000409273.1_Missense_Mutation_p.G483V|XIRP2_ENST00000409728.1_Intron|XIRP2_ENST00000409605.1_Intron	NM_152381.5	NP_689594.4	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2	530					actin cytoskeleton organization	cell junction	actin binding			NS(3)|biliary_tract(2)|breast(5)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(51)|lung(160)|ovary(7)|pancreas(3)|prostate(11)|skin(14)|stomach(5)|upper_aerodigestive_tract(8)|urinary_tract(7)	315						GATCAACTTGGACAGCTTCAT	0.383000													18	52					1.55795e-14	2.26819e-14	1	1	0
OR5R1	219479	broad.mit.edu	37	11	56185334	56185334	+	Silent	SNP	G	G	T			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	a53ffcc4-1471-4a5a-8f8a-1921eae48392	g.chr11:56185334G>T	ENST00000312253.1	-	1	374	c.375C>A	c.(373-375)gcC>gcA	p.A125A		NM_001004744.1	NP_001004744.1	Q8NH85	OR5R1_HUMAN	olfactory receptor, family 5, subfamily R, member 1	125					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|liver(1)|lung(17)|ovary(2)|prostate(3)|stomach(1)|upper_aerodigestive_tract(1)	37	Esophageal squamous(21;0.00448)					GACTACAGATGGCGACATAGC	0.468000													15	74					2.32078e-09	2.96462e-09	1	1	0
FAM171A1	221061	broad.mit.edu	37	10	15263031	15263031	+	Silent	SNP	A	A	T			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	a53ffcc4-1471-4a5a-8f8a-1921eae48392	g.chr10:15263031A>T	ENST00000378116.4	-	6	789	c.783T>A	c.(781-783)ctT>ctA	p.L261L	FAM171A1_ENST00000477161.1_5'UTR	NM_001010924.1	NP_001010924.1	Q5VUB5	F1711_HUMAN	family with sequence similarity 171, member A1	261						integral to membrane				breast(6)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(20)|ovary(3)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	52						CCTGGTGCACAAGACCCAGAC	0.552000													32	63					0	0	1	0	0
ATP10B	23120	broad.mit.edu	37	5	160049472	160049472	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	a53ffcc4-1471-4a5a-8f8a-1921eae48392	g.chr5:160049472C>A	ENST00000327245.5	-	14	2587	c.1741G>T	c.(1741-1743)Gct>Tct	p.A581S	CTC-348L5.1_ENST00000523598.1_RNA	NM_025153.2	NP_079429.2	O94823	AT10B_HUMAN	ATPase, class V, type 10B	581					ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			NS(2)|autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|liver(2)|lung(37)|ovary(4)|pancreas(1)|prostate(5)|skin(3)|stomach(1)	75	Renal(175;0.00196)	Medulloblastoma(196;0.0377)|all_neural(177;0.121)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			AAGAAATCAGCAATGGAGGAG	0.557000													30	25					3.99451e-17	5.94671e-17	1	1	0
SLC45A2	51151	broad.mit.edu	37	5	33951714	33951714	+	Silent	SNP	G	G	T			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	a53ffcc4-1471-4a5a-8f8a-1921eae48392	g.chr5:33951714G>T	ENST00000382102.3	-	5	1158	c.1101C>A	c.(1099-1101)gtC>gtA	p.V367V	SLC45A2_ENST00000342059.3_Silent_p.V308V|SLC45A2_ENST00000509381.1_3'UTR|SLC45A2_ENST00000345083.5_Silent_p.V259V|SLC45A2_ENST00000296589.4_Silent_p.V367V	NM_001012509.2	NP_001012527.1	Q9UMX9	S45A2_HUMAN	solute carrier family 45, member 2	367					melanin biosynthetic process|response to stimulus|transmembrane transport|visual perception	integral to membrane|melanosome membrane				breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(25)|ovary(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	48						ATCCAACCTCGACTCCTCTTT	0.453000													63	111					3.00063e-23	4.75299e-23	1	1	0
IFNA8	3445	broad.mit.edu	37	9	21409660	21409660	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	a53ffcc4-1471-4a5a-8f8a-1921eae48392	g.chr9:21409660G>A	ENST00000380205.1	+	1	515	c.485G>A	c.(484-486)tGt>tAt	p.C162Y		NM_002170.3	NP_002161.2	P32881	IFNA8_HUMAN	interferon, alpha 8	162					blood coagulation|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	extracellular space	cytokine activity|cytokine receptor binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(5)|ovary(1)	9				Lung(24;7.66e-27)|LUSC - Lung squamous cell carcinoma(38;1.4e-13)|OV - Ovarian serous cystadenocarcinoma(39;0.0174)		TACAGCTCTTGTGCCTGGGAG	0.428000													76	232					0	0	1	0	0
TACC2	10579	broad.mit.edu	37	10	123997538	123997538	+	Missense_Mutation	SNP	A	A	T			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	a53ffcc4-1471-4a5a-8f8a-1921eae48392	g.chr10:123997538A>T	ENST00000369005.1	+	18	8674	c.8334A>T	c.(8332-8334)gaA>gaT	p.E2778D	TACC2_ENST00000358010.1_Missense_Mutation_p.E924D|TACC2_ENST00000515603.1_Missense_Mutation_p.E2656D|TACC2_ENST00000334433.3_Missense_Mutation_p.E2778D|TACC2_ENST00000260733.3_Missense_Mutation_p.E856D|TACC2_ENST00000369004.3_Missense_Mutation_p.E838D|TACC2_ENST00000515273.1_Missense_Mutation_p.E2705D|TACC2_ENST00000513429.1_Missense_Mutation_p.E924D|TACC2_ENST00000369000.1_Missense_Mutation_p.E401D|TACC2_ENST00000453444.2_Missense_Mutation_p.E2705D|TACC2_ENST00000360561.3_Missense_Mutation_p.E826D|TACC2_ENST00000369001.1_Missense_Mutation_p.E405D|TACC2_ENST00000368999.1_Missense_Mutation_p.E868D	NM_206862.2	NP_996744.2	O95359	TACC2_HUMAN	transforming, acidic coiled-coil containing protein 2	2778						microtubule organizing center|nucleus	nuclear hormone receptor binding			NS(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(15)|lung(27)|ovary(6)|prostate(3)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	83		all_neural(114;0.0656)|Lung NSC(174;0.136)|all_lung(145;0.17)|Breast(234;0.197)				GCAGGCGGGAAGTGATGGAAA	0.473000													9	25					0	0	1	0	0
MTOR	2475	broad.mit.edu	37	1	11270918	11270918	+	Nonsense_Mutation	SNP	G	G	A			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	a53ffcc4-1471-4a5a-8f8a-1921eae48392	g.chr1:11270918G>A	ENST00000361445.4	-	24	3683	c.3607C>T	c.(3607-3609)Cga>Tga	p.R1203*		NM_004958.3	NP_004949.1	P42345	MTOR_HUMAN	mechanistic target of rapamycin (serine/threonine kinase)	1203					cell growth|cellular response to hypoxia|insulin receptor signaling pathway|nerve growth factor receptor signaling pathway|peptidyl-serine phosphorylation|phosphatidylinositol-mediated signaling|protein autophosphorylation|protein catabolic process|response to amino acid stimulus|response to nutrient|T cell costimulation|TOR signaling cascade	endoplasmic reticulum membrane|Golgi membrane|lysosome|mitochondrial outer membrane|phosphatidylinositol 3-kinase complex|PML body|TORC1 complex|TORC2 complex	ATP binding|phosphoprotein binding|protein serine/threonine kinase activity			breast(5)|central_nervous_system(7)|endometrium(20)|kidney(34)|large_intestine(21)|lung(43)|ovary(9)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	149						TGATTGATTCGGTGTCGCACC	0.393000													5	75					0	0	1	0	0
VWA3A	146177	broad.mit.edu	37	16	22163834	22163834	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	a53ffcc4-1471-4a5a-8f8a-1921eae48392	g.chr16:22163834C>A	ENST00000389397.4	+	32	3452	c.590C>A	c.(589-591)gCg>gAg	p.A197E	VWA3A_ENST00000563755.1_Missense_Mutation_p.A197E|VWA3A_ENST00000389398.5_Missense_Mutation_p.A1095E			A6NCI4	VWA3A_HUMAN	von Willebrand factor A domain containing 3A	1095						extracellular region				haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(1)|skin(1)	7				GBM - Glioblastoma multiforme(48;0.0439)		CCTTCCAGAGCGGCGGTTGAG	0.587000													7	15					0.000274275	0.000301703	1	1	0
MORC3	23515	broad.mit.edu	37	21	37741631	37741631	+	Silent	SNP	T	T	A			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	a53ffcc4-1471-4a5a-8f8a-1921eae48392	g.chr21:37741631T>A	ENST00000400485.1	+	15	2041	c.1965T>A	c.(1963-1965)gtT>gtA	p.V655V	MORC3_ENST00000487909.1_3'UTR	NM_015358.2	NP_056173.1	Q14149	MORC3_HUMAN	MORC family CW-type zinc finger 3	655					cell aging|maintenance of protein location in nucleus|negative regulation of fibroblast proliferation|peptidyl-serine phosphorylation|protein stabilization	aggresome|intermediate filament cytoskeleton|PML body	ATP binding|zinc ion binding			breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(7)|lung(9)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	35						AAGAAACTGTTGAAGACGAGA	0.438000													24	73					0	0	1	0	0
ABRA	137735	broad.mit.edu	37	8	107773518	107773518	+	Missense_Mutation	SNP	C	C	G			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	a53ffcc4-1471-4a5a-8f8a-1921eae48392	g.chr8:107773518C>G	ENST00000311955.3	-	2	947	c.893G>C	c.(892-894)aGg>aCg	p.R298T		NM_139166.4	NP_631905.1	Q8N0Z2	ABRA_HUMAN	actin-binding Rho activating protein	298					positive regulation of Rho protein signal transduction|positive regulation of sequence-specific DNA binding transcription factor activity|transcription, DNA-dependent|transmembrane transport	actin cytoskeleton|plasma membrane|sarcomere	actin binding			breast(1)|kidney(4)|large_intestine(7)|lung(11)|ovary(2)|prostate(2)	27			OV - Ovarian serous cystadenocarcinoma(57;3.83e-09)			ACGCTTGGCCCTTTCAGCAGT	0.517000													16	43					0	0	1	0	0
STAB2	55576	broad.mit.edu	37	12	104077048	104077048	+	Nonsense_Mutation	SNP	C	C	A			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	a53ffcc4-1471-4a5a-8f8a-1921eae48392	g.chr12:104077048C>A	ENST00000388887.2	+	26	3075	c.2871C>A	c.(2869-2871)tgC>tgA	p.C957*		NM_017564.9	NP_060034.9	Q8WWQ8	STAB2_HUMAN	stabilin 2	957	EGF-like 10.				angiogenesis|cell adhesion|defense response to bacterium|receptor-mediated endocytosis	cytoplasm|external side of plasma membrane|integral to plasma membrane	Gram-negative bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			NS(4)|breast(7)|central_nervous_system(1)|cervix(1)|endometrium(15)|kidney(11)|large_intestine(26)|lung(77)|ovary(10)|pancreas(1)|prostate(5)|skin(14)|stomach(2)	174						TAACTTCATGCTTGGAACAAA	0.323000													26	62					1.30897e-18	1.99366e-18	1	1	0
C1orf64	149563	broad.mit.edu	37	1	16330828	16330828	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	a53ffcc4-1471-4a5a-8f8a-1921eae48392	g.chr1:16330828G>T	ENST00000329454.2	+	1	98	c.30G>T	c.(28-30)tgG>tgT	p.W10C		NM_178840.2	NP_849162.1	Q8NEQ6	CA064_HUMAN	chromosome 1 open reading frame 64	10										breast(2)|endometrium(1)|lung(3)	6		Colorectal(325;0.000435)|Renal(390;0.00145)|Breast(348;0.00224)|Lung NSC(340;0.00566)|all_lung(284;0.00831)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.104)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Colorectal(212;3.25e-07)|COAD - Colon adenocarcinoma(227;2.08e-05)|BRCA - Breast invasive adenocarcinoma(304;9.19e-05)|Kidney(64;0.000165)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(313;0.0114)|READ - Rectum adenocarcinoma(331;0.0649)		CCAGGGACTGGAGAGCCAACC	0.642000													4	8					0.00024832	0.000274678	1	1	0
HNRNPD	3184	broad.mit.edu	37	4	83279893	83279893	+	Silent	SNP	C	C	A			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	a53ffcc4-1471-4a5a-8f8a-1921eae48392	g.chr4:83279893C>A	ENST00000313899.7	-	4	817	c.540G>T	c.(538-540)ccG>ccT	p.P180P	HNRNPD_ENST00000541060.1_Silent_p.P26P|HNRNPD_ENST00000353341.4_Silent_p.P180P|HNRNPD_ENST00000543098.1_Silent_p.P128P|HNRNPD_ENST00000352301.4_Silent_p.P161P	NM_031370.2	NP_112738.1	Q14103	HNRPD_HUMAN	heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)	180					nuclear mRNA splicing, via spliceosome|positive regulation of transcription, DNA-dependent|RNA catabolic process|transcription, DNA-dependent	cytosol|heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	nucleotide binding|protein binding|RNA binding|telomeric DNA binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(1)	7						TTTTTTTAACCGGCTCTTTTG	0.363000													26	57					9.90768e-06	1.14721e-05	1	1	0
TET1	80312	broad.mit.edu	37	10	70360780	70360780	+	Missense_Mutation	SNP	A	A	G			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	a53ffcc4-1471-4a5a-8f8a-1921eae48392	g.chr10:70360780A>G	ENST00000373644.4	+	3	2166	c.1957A>G	c.(1957-1959)Aaa>Gaa	p.K653E		NM_030625.2	NP_085128.2	Q8NFU7	TET1_HUMAN	tet methylcytosine dioxygenase 1	653	Sufficient for binding to genomic CpG islands.				DNA demethylation|inner cell mass cell differentiation|negative regulation of methylation-dependent chromatin silencing|stem cell maintenance		iron ion binding|methylcytosine dioxygenase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|structure-specific DNA binding|zinc ion binding			breast(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(2)|ovary(5)|prostate(1)|upper_aerodigestive_tract(2)	21						AAAGAAGCCCAAAGTTTTAAA	0.308000													18	61					0	0	1	0	0
SMG1	23049	broad.mit.edu	37	16	18826847	18826847	+	Missense_Mutation	SNP	T	T	C			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	a53ffcc4-1471-4a5a-8f8a-1921eae48392	g.chr16:18826847T>C	ENST00000446231.2	-	59	10841	c.10429A>G	c.(10429-10431)Atg>Gtg	p.M3477V	SMG1_ENST00000389467.3_Missense_Mutation_p.M3478V			Q96Q15	SMG1_HUMAN	SMG1 phosphatidylinositol 3-kinase-related kinase	3477					DNA repair|mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|peptidyl-serine phosphorylation|phosphatidylinositol phosphorylation|protein autophosphorylation	cytoplasm|nucleus	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			NS(2)|breast(8)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(16)|lung(37)|ovary(1)|skin(1)|stomach(4)|urinary_tract(1)	92						ACCTGACCCATAGCCTGGACT	0.403000													28	67					0	0	1	0	0
CLCN1	1180	broad.mit.edu	37	7	143043333	143043333	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	a53ffcc4-1471-4a5a-8f8a-1921eae48392	g.chr7:143043333C>A	ENST00000343257.2	+	18	2360	c.2273C>A	c.(2272-2274)cCa>cAa	p.P758Q		NM_000083.2	NP_000074.2	P35523	CLCN1_HUMAN	chloride channel, voltage-sensitive 1	758					muscle contraction	chloride channel complex|integral to plasma membrane	voltage-gated chloride channel activity			breast(4)|central_nervous_system(1)|endometrium(1)|large_intestine(11)|lung(26)|ovary(3)|prostate(2)|skin(7)|stomach(1)|upper_aerodigestive_tract(2)	58	Melanoma(164;0.205)					CCGGAAGCACCAGAGCCTGCA	0.592000													13	40					0.00010058	0.000111881	1	1	0
PNLIPRP3	119548	broad.mit.edu	37	10	118203905	118203905	+	Silent	SNP	G	G	A			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	a53ffcc4-1471-4a5a-8f8a-1921eae48392	g.chr10:118203905G>A	ENST00000369230.3	+	4	482	c.336G>A	c.(334-336)caG>caA	p.Q112Q		NM_001011709.2	NP_001011709.2	Q17RR3	LIPR3_HUMAN	pancreatic lipase-related protein 3	112					lipid catabolic process	extracellular region	triglyceride lipase activity			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(9)|lung(29)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	50				all cancers(201;0.0131)		TGTTGCTACAGCTGGAAGATA	0.358000													9	38					0	0	1	0	0
SYNPR	132204	broad.mit.edu	37	3	63429126	63429126	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	a53ffcc4-1471-4a5a-8f8a-1921eae48392	g.chr3:63429126G>T	ENST00000295894.5	+	1	374	c.5G>T	c.(4-6)tGt>tTt	p.C2F	SYNPR_ENST00000479198.1_Missense_Mutation_p.C2F|SYNPR_ENST00000478300.1_Intron|SYNPR_ENST00000478744.1_3'UTR|SYNPR_ENST00000465156.1_Missense_Mutation_p.C2F|SYNPR_ENST00000460711.1_Missense_Mutation_p.C2F|SYNPR-AS1_ENST00000488201.1_RNA	NM_144642.4	NP_653243.1	Q8TBG9	SYNPR_HUMAN	synaptoporin	2	MARVEL.					cell junction|integral to membrane|synaptic vesicle membrane|synaptosome	transporter activity			NS(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(3)	8				BRCA - Breast invasive adenocarcinoma(55;0.000918)|KIRC - Kidney renal clear cell carcinoma(15;0.0658)|Kidney(15;0.0904)		TTGTAAATGTGTATGGTGATA	0.403000													6	11					2.0095e-06	2.38252e-06	1	1	0
PTH2	113091	broad.mit.edu	37	19	49925835	49925835	+	Silent	SNP	G	G	A			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	a53ffcc4-1471-4a5a-8f8a-1921eae48392	g.chr19:49925835G>A	ENST00000270631.1	-	2	294	c.193C>T	c.(193-195)Ctg>Ttg	p.L65L		NM_178449.3	NP_848544.1	Q96A98	TIP39_HUMAN	parathyroid hormone 2	65					neuropeptide signaling pathway	extracellular region				endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|skin(1)	6				OV - Ovarian serous cystadenocarcinoma(262;0.0015)|GBM - Glioblastoma multiforme(486;0.044)|Lung(386;0.0785)|LUSC - Lung squamous cell carcinoma(496;0.0836)		TCGTCCGCCAGCGCCAGGCTC	0.741000													6	10					0	0	1	0	0
HHIPL1	84439	broad.mit.edu	37	14	100118894	100118894	+	Missense_Mutation	SNP	G	G	A	rs145984890		TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	a53ffcc4-1471-4a5a-8f8a-1921eae48392	g.chr14:100118894G>A	ENST00000330710.5	+	2	687	c.589G>A	c.(589-591)Gtg>Atg	p.V197M	HHIPL1_ENST00000357223.2_Missense_Mutation_p.V197M	NM_001127258.1	NP_001120730.1	Q96JK4	HIPL1_HUMAN	HHIP-like 1	197					carbohydrate metabolic process	extracellular region|membrane	oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor|quinone binding|scavenger receptor activity			breast(1)|endometrium(2)|large_intestine(2)|lung(8)|skin(2)	15		Melanoma(154;0.128)				GCGCAACCCCGTGGCCATGGT	0.667000													3	36					0	0	1	0	0
OR8U1	219417	broad.mit.edu	37	11	56143640	56143640	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	a53ffcc4-1471-4a5a-8f8a-1921eae48392	g.chr11:56143640G>T	ENST00000302270.1	+	1	541	c.541G>T	c.(541-543)Gac>Tac	p.D181Y		NM_001005204.1	NP_001005204.1			olfactory receptor, family 8, subfamily U, member 1											NS(1)|breast(2)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(1)|lung(23)|ovary(4)|skin(1)|stomach(1)	39	Esophageal squamous(21;0.00448)					CTATTGTGATGACATGCCTCT	0.458000													55	213					1.14385e-22	1.79749e-22	1	1	0
LRRC17	10234	broad.mit.edu	37	7	102574765	102574765	+	Missense_Mutation	SNP	A	A	T			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	a53ffcc4-1471-4a5a-8f8a-1921eae48392	g.chr7:102574765A>T	ENST00000249377.4	+	2	686	c.405A>T	c.(403-405)ttA>ttT	p.L135F	FBXL13_ENST00000379308.3_Intron|FBXL13_ENST00000379305.3_Intron|LRRC17_ENST00000339431.4_Missense_Mutation_p.L135F|FBXL13_ENST00000313221.4_Intron|FBXL13_ENST00000436908.1_Intron|FBXL13_ENST00000455112.2_Intron|FBXL13_ENST00000456695.1_Intron|FBXL13_ENST00000393772.2_Intron|FBXL13_ENST00000379306.3_Intron	NM_005824.2	NP_005815.2	Q8N6Y2	LRC17_HUMAN	leucine rich repeat containing 17	135					bone marrow development|negative regulation of osteoclast differentiation|ossification	extracellular space				NS(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(5)|liver(2)|lung(3)|ovary(1)|prostate(1)|urinary_tract(1)	17						CCACCCTCTTACTGCAGCACA	0.443000													16	49					0	0	1	0	0
CCDC51	79714	broad.mit.edu	37	3	48473961	48473961	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	a53ffcc4-1471-4a5a-8f8a-1921eae48392	g.chr3:48473961C>A	ENST00000395694.2	-	4	1178	c.1093G>T	c.(1093-1095)Ggg>Tgg	p.G365W	CCDC51_ENST00000395696.1_Missense_Mutation_p.G365W|CCDC51_ENST00000412398.2_Missense_Mutation_p.G256W|CCDC51_ENST00000447018.1_Missense_Mutation_p.G256W|CCDC51_ENST00000442740.1_Missense_Mutation_p.G256W	NM_001256964.1	NP_001243893.1	Q96ER9	CCD51_HUMAN	coiled-coil domain containing 51	365						integral to membrane				endometrium(4)|kidney(4)|large_intestine(1)|lung(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	15				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00551)|Kidney(197;0.00621)		ATCATGCTCCCCTGCTCCAGC	0.552000													3	51					1	1	1	1	0
PPP1R15A	23645	broad.mit.edu	37	19	49377008	49377008	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	a53ffcc4-1471-4a5a-8f8a-1921eae48392	g.chr19:49377008G>A	ENST00000200453.5	+	2	787	c.518G>A	c.(517-519)gGa>gAa	p.G173E		NM_014330.3	NP_055145.3	O75807	PR15A_HUMAN	protein phosphatase 1, regulatory subunit 15A	173	Glu-rich.|Required for localization in the endoplasmic reticulum.				apoptosis|cell cycle arrest|regulation of translation|response to DNA damage stimulus	endoplasmic reticulum	protein binding			breast(1)|endometrium(4)|kidney(1)|large_intestine(6)|lung(8)|skin(2)|urinary_tract(1)	23		all_epithelial(76;5.29e-07)|all_lung(116;1.7e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.000244)|all cancers(93;0.000694)|GBM - Glioblastoma multiforme(486;0.0222)|Epithelial(262;0.033)		GAAGAGGAGGGAGTTAACAAG	0.527000													16	45					0	0	1	0	0
COL1A2	1278	broad.mit.edu	37	7	94053727	94053727	+	Missense_Mutation	SNP	G	G	A	rs140368271		TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	a53ffcc4-1471-4a5a-8f8a-1921eae48392	g.chr7:94053727G>A	ENST00000297268.6	+	41	3116	c.2645G>A	c.(2644-2646)cGt>cAt	p.R882H		NM_000089.3	NP_000080.2	P08123	CO1A2_HUMAN	collagen, type I, alpha 2	882					axon guidance|blood vessel development|collagen fibril organization|leukocyte migration|odontogenesis|platelet activation|regulation of blood pressure|Rho protein signal transduction|skeletal system development|skin morphogenesis|transforming growth factor beta receptor signaling pathway	collagen type I|extracellular space|plasma membrane	extracellular matrix structural constituent|identical protein binding|platelet-derived growth factor binding|protein binding, bridging		COL1A2/PLAG1(3)	NS(2)|breast(2)|central_nervous_system(4)|cervix(1)|endometrium(6)|kidney(8)|large_intestine(21)|lung(51)|ovary(2)|prostate(1)|skin(7)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(1)	115	all_cancers(62;2.46e-09)|all_epithelial(64;2.7e-08)		STAD - Stomach adenocarcinoma(171;0.0031)		Collagenase(DB00048)	AGAGGTGAACGTGGTCTACCA	0.478000										HNSCC(75;0.22)			29	89					0	0	1	0	0
TCF7L1	83439	broad.mit.edu	37	2	85532493	85532493	+	Missense_Mutation	SNP	C	C	A	rs138614113	byFrequency	TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	a53ffcc4-1471-4a5a-8f8a-1921eae48392	g.chr2:85532493C>A	ENST00000282111.3	+	8	1231	c.956C>A	c.(955-957)cCg>cAg	p.P319Q		NM_031283.2	NP_112573.1	Q9HCS4	TF7L1_HUMAN	transcription factor 7-like 1 (T-cell specific, HMG-box)	319	Pro-rich.				chromatin organization|regulation of Wnt receptor signaling pathway|Wnt receptor signaling pathway	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(3)|skin(4)|upper_aerodigestive_tract(1)	18						AAGCAGGAACCGGCACCCCCC	0.662000													3	57					1	1	1	1	0
LLGL1	3996	broad.mit.edu	37	17	18135839	18135839	+	Silent	SNP	C	C	T			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	a53ffcc4-1471-4a5a-8f8a-1921eae48392	g.chr17:18135839C>T	ENST00000316843.4	+	3	306	c.210C>T	c.(208-210)ggC>ggT	p.G70G		NM_004140.3	NP_004131.3	Q15334	L2GL1_HUMAN	lethal giant larvae homolog 1 (Drosophila)	70					cortical actin cytoskeleton organization|exocytosis|protein complex assembly	cortical actin cytoskeleton	protein kinase binding|structural molecule activity			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(6)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	21	all_neural(463;0.228)					AGTTCACAGGCCTGCACCGGG	0.587000													6	20					0	0	1	0	0
AKAP17A	8227	broad.mit.edu	37	X	1714286	1714286	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	a53ffcc4-1471-4a5a-8f8a-1921eae48392	g.chrX:1714286G>T	ENST00000313871.3	+	3	968	c.772G>T	c.(772-774)Gat>Tat	p.D258Y	AKAP17A_ENST00000381261.3_Missense_Mutation_p.D258Y	NM_005088.2	NP_005079.2	Q02040	AK17A_HUMAN	A kinase (PRKA) anchor protein 17A	258					B cell activation|mRNA processing|regulation of transcription, DNA-dependent|RNA splicing|signal transduction	nuclear speck|spliceosomal complex	nucleotide binding|protein binding|RNA binding			breast(2)|endometrium(5)|kidney(3)|large_intestine(1)|lung(12)|prostate(3)	26						GGTTTCTTTTGATTCGACCAA	0.537000													61	87					1.40369e-38	2.41678e-38	1	1	0
STARD13	90627	broad.mit.edu	37	13	33701594	33701594	+	Missense_Mutation	SNP	A	A	T			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	a53ffcc4-1471-4a5a-8f8a-1921eae48392	g.chr13:33701594A>T	ENST00000336934.5	-	6	1954	c.1838T>A	c.(1837-1839)cTg>cAg	p.L613Q	STARD13_ENST00000255486.4_Missense_Mutation_p.L605Q|STARD13_ENST00000399365.3_Missense_Mutation_p.L495Q	NM_001243476.1|NM_178006.3	NP_001230405.1|NP_821074.1	Q9Y3M8	STA13_HUMAN	StAR-related lipid transfer (START) domain containing 13	613					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|lipid particle|mitochondrial membrane	GTPase activator activity|protein binding			breast(2)|endometrium(2)|kidney(3)|large_intestine(6)|lung(18)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|soft_tissue(1)|upper_aerodigestive_tract(1)	40	all_epithelial(80;0.155)	Lung SC(185;0.0367)		all cancers(112;1.31e-05)|Epithelial(112;0.000142)|BRCA - Breast invasive adenocarcinoma(63;0.00936)|OV - Ovarian serous cystadenocarcinoma(117;0.0533)|Lung(94;0.143)|GBM - Glioblastoma multiforme(144;0.143)		GAGCAGGCTCAGCTGGCTGGC	0.627000													10	16					0	0	1	0	0
HKDC1	80201	broad.mit.edu	37	10	71026382	71026382	+	Nonsense_Mutation	SNP	C	C	T			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	a53ffcc4-1471-4a5a-8f8a-1921eae48392	g.chr10:71026382C>T	ENST00000354624.5	+	18	2756	c.2623C>T	c.(2623-2625)Cag>Tag	p.Q875*	RP11-227H15.5_ENST00000413220.1_RNA	NM_025130.3	NP_079406.3	Q2TB90	HKDC1_HUMAN	hexokinase domain containing 1	875					glycolysis	mitochondrion|nucleus	ATP binding|hexokinase activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(11)|ovary(5)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	34						TAGAATATTGCAGGAAACTGT	0.403000													26	88					0	0	1	0	0
OR51S1	119692	broad.mit.edu	37	11	4869599	4869599	+	Silent	SNP	A	A	G			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	a53ffcc4-1471-4a5a-8f8a-1921eae48392	g.chr11:4869599A>G	ENST00000322101.2	-	1	915	c.840T>C	c.(838-840)caT>caC	p.H280H	MMP26_ENST00000477339.1_Intron|MMP26_ENST00000380390.1_Intron	NM_001004758.1	NP_001004758.1	Q8NGJ8	O51S1_HUMAN	olfactory receptor, family 51, subfamily S, member 1	280					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(3)|lung(15)|ovary(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	33		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;5.06e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00438)|LUSC - Lung squamous cell carcinoma(625;0.19)		ATAGAAGAGTATGGGTATGCT	0.448000													34	87					0	0	1	0	0
ABCC11	85320	broad.mit.edu	37	16	48234284	48234284	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	a53ffcc4-1471-4a5a-8f8a-1921eae48392	g.chr16:48234284G>A	ENST00000394747.1	-	14	2334	c.1985C>T	c.(1984-1986)tCt>tTt	p.S662F	ABCC11_ENST00000356608.2_Missense_Mutation_p.S662F|ABCC11_ENST00000537808.1_Missense_Mutation_p.S662F|ABCC11_ENST00000394748.1_Missense_Mutation_p.S662F|ABCC11_ENST00000353782.5_Missense_Mutation_p.S662F	NM_033151.3	NP_149163.2	Q96J66	ABCCB_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 11	662	ABC transporter 1.					integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(3)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(42)|ovary(3)|prostate(2)|skin(5)|urinary_tract(2)	83		all_cancers(37;0.127)|all_lung(18;0.132)|Breast(268;0.166)				GTCCACAGCAGACAGGGGGTC	0.612000													17	57					0	0	1	0	0
STAB1	23166	broad.mit.edu	37	3	52544224	52544224	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	a53ffcc4-1471-4a5a-8f8a-1921eae48392	g.chr3:52544224C>A	ENST00000321725.6	+	24	2677	c.2601C>A	c.(2599-2601)caC>caA	p.H867Q		NM_015136.2	NP_055951.2	Q9NY15	STAB1_HUMAN	stabilin 1	867	EGF-like 7.				cell adhesion|cell-cell signaling|defense response to bacterium|inflammatory response|negative regulation of angiogenesis|receptor-mediated endocytosis	integral to plasma membrane	bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			breast(4)|central_nervous_system(3)|endometrium(7)|kidney(2)|large_intestine(13)|liver(1)|lung(27)|ovary(1)|pancreas(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(3)	76				BRCA - Breast invasive adenocarcinoma(193;1.73e-05)|Kidney(197;0.00182)|KIRC - Kidney renal clear cell carcinoma(197;0.00205)|OV - Ovarian serous cystadenocarcinoma(275;0.0482)		CCTGCTCCCACCCGGACCGTG	0.622000													18	79					0.006122	0.00641353	1	1	0
POF1B	79983	broad.mit.edu	37	X	84585975	84585975	+	Missense_Mutation	SNP	A	A	T			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	a53ffcc4-1471-4a5a-8f8a-1921eae48392	g.chrX:84585975A>T	ENST00000262753.4	-	7	979	c.834T>A	c.(832-834)caT>caA	p.H278Q	POF1B_ENST00000373145.3_Missense_Mutation_p.H278Q	NM_024921.3	NP_079197.3	Q8WVV4	POF1B_HUMAN	premature ovarian failure, 1B	278							actin binding			central_nervous_system(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(3)|liver(2)|lung(17)|ovary(1)|prostate(1)	35						TTCTCTGCAAATGTTCTAATA	0.368000													15	11					0	0	1	0	0
UCK2	7371	broad.mit.edu	37	1	165872437	165872437	+	Missense_Mutation	SNP	A	A	T			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	a53ffcc4-1471-4a5a-8f8a-1921eae48392	g.chr1:165872437A>T	ENST00000367879.4	+	5	821	c.518A>T	c.(517-519)gAg>gTg	p.E173V	UCK2_ENST00000479872.1_3'UTR|UCK2_ENST00000372212.4_Silent_p.R125R	NM_012474.4	NP_036606.2	Q9BZX2	UCK2_HUMAN	uridine-cytidine kinase 2	173					pyrimidine base metabolic process|pyrimidine nucleoside salvage	cytosol	ATP binding|phosphotransferase activity, alcohol group as acceptor|uridine kinase activity			breast(1)|endometrium(2)|large_intestine(2)|lung(3)|ovary(1)|upper_aerodigestive_tract(1)	10	all_hematologic(923;0.048)|Acute lymphoblastic leukemia(8;0.155)					GACATCAGCGAGAGAGGCAGG	0.483000													7	150					0	0	1	0	0
ASTN2	23245	broad.mit.edu	37	9	119976989	119976989	+	Silent	SNP	C	C	A			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	a53ffcc4-1471-4a5a-8f8a-1921eae48392	g.chr9:119976989C>A	ENST00000313400.4	-	3	763	c.663G>T	c.(661-663)ctG>ctT	p.L221L	ASTN2_ENST00000373996.3_Silent_p.L221L|ASTN2_ENST00000361477.3_5'UTR|ASTN2_ENST00000361209.2_Silent_p.L221L			O75129	ASTN2_HUMAN	astrotactin 2	221						integral to membrane				breast(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(21)|lung(45)|ovary(4)|pancreas(2)|prostate(2)|skin(9)|stomach(1)|urinary_tract(1)	102						CGGTGAACACCAGCAGCAGCA	0.597000													16	31					6.94344e-10	8.92728e-10	1	1	0
CCDC136	64753	broad.mit.edu	37	7	128441511	128441511	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	a53ffcc4-1471-4a5a-8f8a-1921eae48392	g.chr7:128441511G>T	ENST00000297788.4	+	4	985	c.618G>T	c.(616-618)aaG>aaT	p.K206N	CCDC136_ENST00000378685.4_Missense_Mutation_p.K256N|CCDC136_ENST00000464832.1_Missense_Mutation_p.K256N|CCDC136_ENST00000487361.1_Missense_Mutation_p.K206N	NM_022742.4	NP_073579.4	Q96JN2	CC136_HUMAN	coiled-coil domain containing 136	206	Glu-rich.					integral to membrane	protein binding			breast(2)|endometrium(3)|kidney(1)|large_intestine(4)|lung(11)|ovary(3)	24						TGGAAATGAAGAGCTCTGAAC	0.483000													4	20					0.000602214	0.000658776	1	1	0
CBX5	23468	broad.mit.edu	37	12	54645824	54645824	+	Splice_Site	SNP	C	C	T			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	a53ffcc4-1471-4a5a-8f8a-1921eae48392	g.chr12:54645824C>T	ENST00000209875.4	-	3	461		c.e3+1		CBX5_ENST00000550411.1_Splice_Site|CBX5_ENST00000439541.2_Splice_Site	NM_012117.2	NP_036249.1	P45973	CBX5_HUMAN	chromobox homolog 5						blood coagulation|interspecies interaction between organisms|negative regulation of transcription, DNA-dependent	cytoplasm|histone deacetylase complex|histone methyltransferase complex|nuclear centromeric heterochromatin|nuclear envelope|nucleolus|transcriptional repressor complex	methylated histone residue binding|protein binding, bridging|repressing transcription factor binding			endometrium(1)|kidney(1)|large_intestine(2)|lung(1)|prostate(1)|skin(2)	8						AGGAAGCTTACCTCTCTCTTT	0.323000													26	131					0	0	1	0	0
MICAL3	57553	broad.mit.edu	37	22	18300822	18300822	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	a53ffcc4-1471-4a5a-8f8a-1921eae48392	g.chr22:18300822C>A	ENST00000441493.2	-	26	4957	c.4605G>T	c.(4603-4605)gaG>gaT	p.E1535D		NM_015241.2	NP_056056.2	Q7RTP6	MICA3_HUMAN	microtubule associated monooxygenase, calponin and LIM domain containing 3	1535						cytoplasm|cytoskeleton	monooxygenase activity|zinc ion binding			large_intestine(1)|lung(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	4		all_epithelial(15;0.198)		Lung(27;0.0427)		GGCTTGAGTCCTCAGTCTTGT	0.627000													8	22					0.00307968	0.00326084	1	1	0
SPANXN2	494119	broad.mit.edu	37	X	142795254	142795254	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	a53ffcc4-1471-4a5a-8f8a-1921eae48392	g.chrX:142795254C>A	ENST00000370498.1	-	2	1177	c.424G>T	c.(424-426)Gac>Tac	p.D142Y		NM_001009615.1	NP_001009615.1	Q5MJ10	SPXN2_HUMAN	SPANX family, member N2	142										NS(1)|breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(17)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	27	Acute lymphoblastic leukemia(192;6.56e-05)					TCAGATGAGTCCAGGTCTTCG	0.512000													88	91					7.8029e-68	1.35524e-67	1	1	0
NTRK1	4914	broad.mit.edu	37	1	156845419	156845419	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	a53ffcc4-1471-4a5a-8f8a-1921eae48392	g.chr1:156845419G>A	ENST00000368196.3	+	11	1564	c.1444G>A	c.(1444-1446)Ggc>Agc	p.G482S	NTRK1_ENST00000358660.3_Missense_Mutation_p.G482S|NTRK1_ENST00000392302.2_Missense_Mutation_p.G452S|NTRK1_ENST00000524377.1_Missense_Mutation_p.G488S	NM_001012331.1	NP_001012331.1	P04629	NTRK1_HUMAN	neurotrophic tyrosine kinase, receptor, type 1	488	Interaction with SQSTM1 (By similarity).				activation of adenylate cyclase activity|activation of MAPKK activity|activation of phospholipase C activity|cell differentiation|nerve growth factor receptor signaling pathway|nervous system development|phosphatidylinositol-mediated signaling|Ras protein signal transduction	endosome|integral to plasma membrane	ATP binding|neurotrophin receptor activity|transmembrane receptor protein serine/threonine kinase activity|transmembrane receptor protein tyrosine kinase activity			breast(3)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(7)|lung(35)|ovary(8)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	74	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)				Imatinib(DB00619)	TGGGCTCCAAGGCCACATCAT	0.587000			T	"""TPM3, TPR, TFG"""	papillary thyroid					TSP Lung(10;0.080)			22	58					0	0	1	0	0
OR10AG1	282770	broad.mit.edu	37	11	55735796	55735796	+	Silent	SNP	A	A	G			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	a53ffcc4-1471-4a5a-8f8a-1921eae48392	g.chr11:55735796A>G	ENST00000312345.2	-	1	194	c.144T>C	c.(142-144)acT>acC	p.T48T		NM_001005491.1	NP_001005491.1	Q8NH19	O10AG_HUMAN	olfactory receptor, family 10, subfamily AG, member 1	48					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(24)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)	40	Esophageal squamous(21;0.0137)					AATACATGGGAGTCTGGAGAG	0.338000													6	113					0	0	1	0	0
PCDHA10	56139	broad.mit.edu	37	5	140236822	140236822	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	a53ffcc4-1471-4a5a-8f8a-1921eae48392	g.chr5:140236822G>T	ENST00000307360.5	+	1	1189	c.1189G>T	c.(1189-1191)Gtg>Ttg	p.V397L	PCDHA9_ENST00000532602.1_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA10_ENST00000506939.2_Missense_Mutation_p.V397L|PCDHA1_ENST00000504120.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA3_ENST00000522353.2_Intron	NM_018901.2|NM_031859.1	NP_061724.1|NP_114065.1														NS(1)|breast(11)|cervix(1)|endometrium(11)|kidney(5)|large_intestine(13)|liver(2)|lung(20)|ovary(3)|pancreas(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(2)	79			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GTTCAAGCTGGTGTCCACCTA	0.592000													50	212					4.02871e-13	5.61749e-13	1	1	0
TTN	7273	broad.mit.edu	37	2	179545040	179545040	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	a53ffcc4-1471-4a5a-8f8a-1921eae48392	g.chr2:179545040C>A	ENST00000589042.1	-	139	33583	c.33359G>T	c.(33358-33360)aGg>aTg	p.R11120M	TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.R9876M|TTN_ENST00000591111.1_Missense_Mutation_p.R10803M|TTN-AS1_ENST00000589830.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron|TTN-AS1_ENST00000431752.1_RNA|TTN_ENST00000359218.5_Intron|TTN_ENST00000342175.6_Intron|TTN-AS1_ENST00000589487.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	10803	Glu-rich.|Pro-rich.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TGCGACAACCCTCTTGGGCTT	0.403000													45	143					9.58827e-17	1.41677e-16	1	1	0
SEMA3D	223117	broad.mit.edu	37	7	84629152	84629152	+	Silent	SNP	C	C	A			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	a53ffcc4-1471-4a5a-8f8a-1921eae48392	g.chr7:84629152C>A	ENST00000284136.6	-	17	1981	c.1938G>T	c.(1936-1938)acG>acT	p.T646T	SEMA3D_ENST00000484038.1_5'UTR	NM_152754.2	NP_689967.2	O95025	SEM3D_HUMAN	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D	646	Ig-like C2-type.				cell differentiation|nervous system development	extracellular region|membrane	receptor activity			NS(1)|breast(2)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(19)|lung(29)|ovary(3)|pancreas(1)|prostate(4)|skin(2)	73						GCCCATATTCCGTTTTGATGA	0.408000													11	23					0.000978159	0.00105258	1	1	0
PBRM1	55193	broad.mit.edu	37	3	52584762	52584762	+	Splice_Site	SNP	C	C	A			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	a53ffcc4-1471-4a5a-8f8a-1921eae48392	g.chr3:52584762C>A	ENST00000356770.4	-	26	4422		c.e26+1		PBRM1_ENST00000409767.1_Splice_Site|PBRM1_ENST00000409114.3_Splice_Site|PBRM1_ENST00000409057.1_Splice_Site|SMIM4_ENST00000476842.1_Intron|PBRM1_ENST00000410007.1_Splice_Site|PBRM1_ENST00000394830.3_Splice_Site|PBRM1_ENST00000296302.7_Splice_Site|PBRM1_ENST00000337303.4_Splice_Site			Q86U86	PB1_HUMAN	polybromo 1						chromatin remodeling|mitosis|negative regulation of cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear chromosome	chromatin binding|DNA binding|protein binding			breast(5)|endometrium(5)|kidney(301)|liver(1)|lung(22)|pancreas(1)	335				BRCA - Breast invasive adenocarcinoma(193;1.8e-05)|Kidney(197;0.00105)|KIRC - Kidney renal clear cell carcinoma(197;0.00122)|OV - Ovarian serous cystadenocarcinoma(275;0.0613)		GGGAGGCTCACCTGTTGTCCA	0.478000			"""Mis, N, F, S, D, O"""		"""clear cell renal carcinoma, breast"""								19	23					2.94398e-08	3.71279e-08	1	1	0
KIAA0100	9703	broad.mit.edu	37	17	26968943	26968943	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	a53ffcc4-1471-4a5a-8f8a-1921eae48392	g.chr17:26968943C>A	ENST00000528896.2	-	7	804	c.730G>T	c.(730-732)Ggc>Tgc	p.G244C	KIAA0100_ENST00000544884.1_Missense_Mutation_p.G101C|KIAA0100_ENST00000389003.3_Missense_Mutation_p.G101C	NM_014680.3	NP_055495.2	Q14667	K0100_HUMAN	KIAA0100	244						extracellular region				breast(3)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(13)|lung(23)|ovary(2)|prostate(2)|skin(6)|stomach(2)|urinary_tract(3)	68	Lung NSC(42;0.00431)					AGGCTTGGGCCCTGGCACAGC	0.527000													13	48					0.00136819	0.00146434	1	1	0
HDHD1	8226	broad.mit.edu	37	X	6995490	6995490	+	Splice_Site	SNP	C	C	A			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	a53ffcc4-1471-4a5a-8f8a-1921eae48392	g.chrX:6995490C>A	ENST00000381077.5	-	3	357	c.280_splice	c.e3-1	p.G94_splice	HDHD1_ENST00000540122.1_Splice_Site_p.G94_splice|HDHD1_ENST00000424830.2_Splice_Site_p.G117_splice|HDHD1_ENST00000412827.2_Splice_Site_p.G51_splice	NM_001178136.1|NM_012080.4	NP_001171607.1|NP_036212.3	Q08623	HDHD1_HUMAN	haloacid dehalogenase-like hydrolase domain containing 1	94					nucleotide metabolic process		metal ion binding|phosphatase activity			breast(2)|large_intestine(1)|lung(3)	6						TTTCTCCGCCCCTGGGGAGGA	0.612000													8	7					7.48243e-07	9.08909e-07	1	1	0
PLCG2	5336	broad.mit.edu	37	16	81934352	81934352	+	Silent	SNP	G	G	T			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	a53ffcc4-1471-4a5a-8f8a-1921eae48392	g.chr16:81934352G>T	ENST00000359376.3	+	14	1543	c.1329G>T	c.(1327-1329)tcG>tcT	p.S443S		NM_002661.3	NP_002652.2	P16885	PLCG2_HUMAN	phospholipase C, gamma 2 (phosphatidylinositol-specific)	443	PI-PLC X-box.				intracellular signal transduction|phospholipid catabolic process|platelet activation	plasma membrane	phosphatidylinositol phospholipase C activity|protein binding|signal transducer activity			NS(1)|breast(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(18)|lung(21)|ovary(1)|prostate(2)|skin(2)|urinary_tract(1)	58						AGCTGCCCTCGCCCAGCCAGC	0.637000													14	27					4.14922e-12	5.70517e-12	1	1	0
SLC35F3	148641	broad.mit.edu	37	1	234455930	234455930	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	a53ffcc4-1471-4a5a-8f8a-1921eae48392	g.chr1:234455930G>T	ENST00000366618.3	+	7	1379	c.1234G>T	c.(1234-1236)Gca>Tca	p.A412S	SLC35F3_ENST00000366617.3_Missense_Mutation_p.A343S	NM_173508.2	NP_775779.1	Q8IY50	S35F3_HUMAN	solute carrier family 35, member F3	343					transport	integral to membrane				breast(2)|endometrium(3)|kidney(2)|large_intestine(7)|lung(13)|ovary(2)|skin(2)|urinary_tract(1)	32	Ovarian(103;0.0454)	all_cancers(173;0.145)|Prostate(94;0.0885)	OV - Ovarian serous cystadenocarcinoma(106;0.00531)			ACCTGTGAATGCAGGTAAACC	0.398000													17	82					3.51602e-12	4.86833e-12	1	1	0
TEP1	7011	broad.mit.edu	37	14	20849819	20849819	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	a53ffcc4-1471-4a5a-8f8a-1921eae48392	g.chr14:20849819C>A	ENST00000262715.5	-	31	4491	c.4451G>T	c.(4450-4452)cGc>cTc	p.R1484L	TEP1_ENST00000556935.1_Missense_Mutation_p.R1376L|TEP1_ENST00000545983.1_Intron	NM_007110.4	NP_009041.2	Q99973	TEP1_HUMAN	telomerase-associated protein 1	1484	NACHT.				telomere maintenance via recombination	chromosome, telomeric region|cytoplasm|nuclear matrix|soluble fraction|telomerase holoenzyme complex	ATP binding|RNA binding			NS(4)|breast(1)|central_nervous_system(4)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(48)|ovary(7)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	96	all_cancers(95;0.00123)	all_lung(585;0.235)	Epithelial(56;7.42e-08)|all cancers(55;6.46e-07)	GBM - Glioblastoma multiforme(265;0.028)|READ - Rectum adenocarcinoma(17;0.233)		GGCACCAGGGCGCTCCAGAGG	0.617000													30	52					7.26314e-15	1.06526e-14	1	1	0
OR4M2	390538	broad.mit.edu	37	15	22369056	22369056	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	a53ffcc4-1471-4a5a-8f8a-1921eae48392	g.chr15:22369056G>T	ENST00000332663.2	+	1	579	c.481G>T	c.(481-483)Gct>Tct	p.A161S	RP11-69H14.6_ENST00000558896.1_RNA	NM_001004719.2	NP_001004719.2	Q8NGB6	OR4M2_HUMAN	olfactory receptor, family 4, subfamily M, member 2	161					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(2)|endometrium(2)|kidney(4)|large_intestine(6)|lung(38)|ovary(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(3)	63		all_cancers(20;1.94e-20)|all_epithelial(15;3.94e-18)|Lung NSC(15;8.53e-15)|all_lung(15;2.87e-14)|Breast(32;0.00519)|Colorectal(260;0.101)	GBM - Glioblastoma multiforme(6;0.124)	all cancers(64;1.64e-11)|Epithelial(43;5.81e-10)|BRCA - Breast invasive adenocarcinoma(123;0.000255)|Kidney(6;0.00736)|KIRC - Kidney renal clear cell carcinoma(6;0.0135)|GBM - Glioblastoma multiforme(186;0.0963)		CATACAGGTGGCTCTCATTGT	0.517000													55	263					2.76378e-25	4.48549e-25	1	1	0
WFIKKN2	124857	broad.mit.edu	37	17	48917283	48917283	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	a53ffcc4-1471-4a5a-8f8a-1921eae48392	g.chr17:48917283C>A	ENST00000311378.4	+	2	1162	c.634C>A	c.(634-636)Ctg>Atg	p.L212M	WFIKKN2_ENST00000426127.1_Missense_Mutation_p.L119M	NM_175575.5	NP_783165.1	Q8TEU8	WFKN2_HUMAN	WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2	212	Ig-like C2-type.					extracellular region	metalloendopeptidase inhibitor activity|protein binding|serine-type endopeptidase inhibitor activity			cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(3)|lung(13)|ovary(4)|skin(1)	29			BRCA - Breast invasive adenocarcinoma(22;1.09e-08)			GGCCCCTGCGCTGCTCAACAA	0.652000													9	49					0.0581538	0.0596603	1	1	0
MAZ	4150	broad.mit.edu	37	16	29821465	29821465	+	Missense_Mutation	SNP	A	A	G			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	a53ffcc4-1471-4a5a-8f8a-1921eae48392	g.chr16:29821465A>G	ENST00000563402.1	+	3	447	c.316A>G	c.(316-318)Agc>Ggc	p.S106G	AC009133.20_ENST00000569039.1_RNA|MAZ_ENST00000568544.1_Silent_p.V50V|MAZ_ENST00000562337.1_Silent_p.V144V|MAZ_ENST00000568282.1_3'UTR|MAZ_ENST00000219782.6_3'UTR|MAZ_ENST00000566906.2_Missense_Mutation_p.S104G|MAZ_ENST00000545521.1_Silent_p.V426V|MAZ_ENST00000322945.6_Silent_p.V449V|AC009133.14_ENST00000569981.1_RNA			P56270	MAZ_HUMAN	MYC-associated zinc finger protein (purine-binding transcription factor)	106	Poly-Ala.				regulation of transcription, DNA-dependent|termination of RNA polymerase II transcription|transcription initiation from RNA polymerase II promoter	nucleus	DNA binding|protein binding|RNA binding|zinc ion binding			endometrium(3)|lung(4)|ovary(2)|upper_aerodigestive_tract(1)	10						cggcagcagtagcagcCCCTC	0.672000													6	13					0	0	1	0	0
SMG7	9887	broad.mit.edu	37	1	183515445	183515445	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	a53ffcc4-1471-4a5a-8f8a-1921eae48392	g.chr1:183515445G>T	ENST00000367537.3	+	18	2859	c.2664G>T	c.(2662-2664)caG>caT	p.Q888H	SMG7_ENST00000515829.2_Missense_Mutation_p.Q859H|SMG7_ENST00000347615.2_Missense_Mutation_p.Q905H|SMG7_ENST00000507469.1_Missense_Mutation_p.Q859H|SMG7_ENST00000456731.2_Missense_Mutation_p.Q817H|SMG7_ENST00000508461.1_Missense_Mutation_p.Q863H			Q92540	SMG7_HUMAN	SMG7 nonsense mediated mRNA decay factor	905					mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of dephosphorylation	cytoplasm|intermediate filament cytoskeleton|nucleus	protein phosphatase 2A binding			breast(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(7)|lung(16)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	46						GTCCAGAGCAGGATCCTGTAC	0.473000													22	62					1.36565e-18	2.06411e-18	1	1	0
LRRC75A-AS1	125144	broad.mit.edu	37	17	16342490	16342490	+	RNA	SNP	C	C	T			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	a53ffcc4-1471-4a5a-8f8a-1921eae48392	g.chr17:16342490C>T	ENST00000475953.1	+	0	132				C17orf76-AS1_ENST00000583400.2_RNA|C17orf76-AS1_ENST00000584926.1_RNA|C17orf76-AS1_ENST00000584141.1_RNA|C17orf76-AS1_ENST00000584177.1_RNA|C17orf76-AS1_ENST00000581913.1_RNA|C17orf76-AS1_ENST00000581718.1_RNA|C17orf76-AS1_ENST00000475947.2_RNA|C17orf76-AS1_ENST00000582911.1_RNA|C17orf76-AS1_ENST00000580770.1_RNA|C17orf76-AS1_ENST00000580180.1_RNA|C17orf76-AS1_ENST00000579473.1_RNA|C17orf76-AS1_ENST00000481898.1_RNA|C17orf76-AS1_ENST00000470491.2_RNA|C17orf76-AS1_ENST00000578380.2_RNA|C17orf76-AS1_ENST00000477249.2_RNA|C17orf76-AS1_ENST00000492250.1_RNA|C17orf76-AS1_ENST00000487066.1_RNA	NR_027667.1																						GGGCGGAGGGCAGCTGTTGAG	0.667000													7	35					0	0	1	0	0
NMUR2	56923	broad.mit.edu	37	5	151777686	151777686	+	Missense_Mutation	SNP	A	A	G			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	a53ffcc4-1471-4a5a-8f8a-1921eae48392	g.chr5:151777686A>G	ENST00000255262.3	-	2	911	c.746T>C	c.(745-747)cTt>cCt	p.L249P	NMUR2_ENST00000518933.1_5'UTR	NM_020167.4	NP_064552.3	Q9GZQ4	NMUR2_HUMAN	neuromedin U receptor 2	249					activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|arachidonic acid secretion|calcium ion transport|central nervous system development|elevation of cytosolic calcium ion concentration|regulation of smooth muscle contraction	integral to membrane|plasma membrane	GTP binding|intracellular calcium activated chloride channel activity|neuromedin U receptor activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(12)|liver(1)|lung(15)|ovary(3)|pancreas(1)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)	44		Medulloblastoma(196;0.091)|all_hematologic(541;0.103)	Kidney(363;0.000106)|KIRC - Kidney renal clear cell carcinoma(527;0.000672)			ATCTGCCTCAAGAGATTTGTC	0.358000													27	54					0	0	1	0	0
MAX	4149	broad.mit.edu	37	14	65560493	65560493	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	a53ffcc4-1471-4a5a-8f8a-1921eae48392	g.chr14:65560493C>A	ENST00000284165.6	-	3	252	c.104G>T	c.(103-105)cGt>cTt	p.R35L	MAX_ENST00000246163.2_Missense_Mutation_p.R35L|MAX_ENST00000358664.4_Missense_Mutation_p.R35L|MAX_ENST00000341653.2_Missense_Mutation_p.R35L|MAX_ENST00000557277.1_5'UTR|MAX_ENST00000555932.1_Intron|MAX_ENST00000555667.1_Missense_Mutation_p.R26L|MAX_ENST00000556443.1_Missense_Mutation_p.R26L|MAX_ENST00000557746.1_Missense_Mutation_p.R26L|MAX_ENST00000358402.4_Missense_Mutation_p.R26L|MAX_ENST00000556979.1_Missense_Mutation_p.R35L|RP11-840I19.3_ENST00000555261.1_RNA|MAX_ENST00000555419.1_Intron|RP11-840I19.3_ENST00000553633.1_RNA|RP11-840I19.3_ENST00000555898.1_RNA	NM_145113.1	NP_660088.1	P61244	MAX_HUMAN	MYC associated factor X	35					transcription from RNA polymerase II promoter	cytoplasm|MLL1 complex	sequence-specific DNA binding transcription factor activity|transcription coactivator activity	p.R35H(1)		breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(1)|lung(3)|prostate(1)|skin(1)	17				all cancers(60;0.000776)|OV - Ovarian serous cystadenocarcinoma(108;0.00359)|BRCA - Breast invasive adenocarcinoma(234;0.00999)		GTGGTCCCTACGTTTTCGTTC	0.478000													25	42					2.48779e-11	3.39713e-11	1	1	0
TMEM147	10430	broad.mit.edu	37	19	36038271	36038271	+	Silent	SNP	G	G	T			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	a53ffcc4-1471-4a5a-8f8a-1921eae48392	g.chr19:36038271G>T	ENST00000392204.2	+	6	778	c.450G>T	c.(448-450)ctG>ctT	p.L150L	TMEM147_ENST00000392205.1_3'UTR|TMEM147_ENST00000222284.5_Silent_p.L199L	NM_001242597.1	NP_001229526.1	Q9BVK8	TM147_HUMAN	transmembrane protein 147	199						endoplasmic reticulum membrane|integral to membrane	protein binding			endometrium(1)|large_intestine(2)|lung(2)|prostate(1)	6	all_lung(56;1.05e-07)|Lung NSC(56;1.63e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0724)			CAGCTCTACTGGCCCGAGCAG	0.562000													3	50					1	1	1	1	0
OR11L1	391189	broad.mit.edu	37	1	248004356	248004356	+	Silent	SNP	G	G	T			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	a53ffcc4-1471-4a5a-8f8a-1921eae48392	g.chr1:248004356G>T	ENST00000355784.2	-	1	898	c.843C>A	c.(841-843)gtC>gtA	p.V281V		NM_001001959.1	NP_001001959.1	Q8NGX0	O11L1_HUMAN	olfactory receptor, family 11, subfamily L, member 1	281					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(4)|kidney(5)|large_intestine(5)|lung(35)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	57	all_cancers(71;8.78e-05)|all_epithelial(71;9.15e-06)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.0786)|Lung NSC(105;0.0858)		OV - Ovarian serous cystadenocarcinoma(106;0.0319)			GCAGTGGTGTGACCACAGTGT	0.443000													20	88					3.62473e-10	4.69083e-10	1	1	0
TOPORS	10210	broad.mit.edu	37	9	32541434	32541434	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	a53ffcc4-1471-4a5a-8f8a-1921eae48392	g.chr9:32541434C>A	ENST00000360538.2	-	3	3205	c.3089G>T	c.(3088-3090)cGg>cTg	p.R1030L	TOPORS_ENST00000379858.1_Missense_Mutation_p.R965L	NM_005802.4	NP_005793.2	Q9NS56	TOPRS_HUMAN	topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase	1030					DNA damage response, signal transduction resulting in induction of apoptosis|maintenance of protein location in nucleus|proteasomal ubiquitin-dependent protein catabolic process|protein sumoylation|transcription, DNA-dependent	nuclear speck|PML body	antigen binding|DNA binding|DNA topoisomerase I binding|SUMO ligase activity|ubiquitin-protein ligase activity|zinc ion binding			large_intestine(6)|ovary(3)|skin(2)|upper_aerodigestive_tract(1)	12			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.0018)		TAATGATGTCCGTGGCGATGG	0.393000													21	56					1.01871e-10	1.33579e-10	1	1	0
PASD1	139135	broad.mit.edu	37	X	150832592	150832592	+	Splice_Site	SNP	C	C	G			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	a53ffcc4-1471-4a5a-8f8a-1921eae48392	g.chrX:150832592C>G	ENST00000370357.4	+	11	1088	c.841_splice	c.e11-1	p.A281_splice		NM_173493.2	NP_775764.2	Q8IV76	PASD1_HUMAN	PAS domain containing 1	281						nucleus	signal transducer activity			breast(2)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(3)|liver(1)|lung(25)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	48	Acute lymphoblastic leukemia(192;6.56e-05)					CTTCCTCAGCCTTATCCTTGC	0.468000													28	14					0	0	1	0	0
EMR2	30817	broad.mit.edu	37	19	14875377	14875377	+	Missense_Mutation	SNP	G	G	T	rs150544869		TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	a53ffcc4-1471-4a5a-8f8a-1921eae48392	g.chr19:14875377G>T	ENST00000315576.3	-	11	1403	c.952C>A	c.(952-954)Ctg>Atg	p.L318M	EMR2_ENST00000594294.1_Missense_Mutation_p.L269M|EMR2_ENST00000346057.1_Missense_Mutation_p.L269M|EMR2_ENST00000392967.2_Missense_Mutation_p.L318M|EMR2_ENST00000392965.3_Missense_Mutation_p.L318M|EMR2_ENST00000595839.1_Missense_Mutation_p.L176M|EMR2_ENST00000601345.1_Missense_Mutation_p.L318M|EMR2_ENST00000353005.1_Missense_Mutation_p.L176M|EMR2_ENST00000353876.1_Missense_Mutation_p.L225M|EMR2_ENST00000594076.1_Missense_Mutation_p.L225M|EMR2_ENST00000596991.2_Missense_Mutation_p.L318M|EMR2_ENST00000392964.3_Missense_Mutation_p.L57M	NM_013447.2	NP_038475.2	Q9UHX3	EMR2_HUMAN	egf-like module containing, mucin-like, hormone receptor-like 2	318					cell adhesion|neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			breast(1)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(8)|lung(19)|ovary(1)|prostate(2)|skin(6)|upper_aerodigestive_tract(1)	48						AGGGTCTCCAGGTCCCCAGGG	0.612000													11	49					1.08611e-07	1.32747e-07	1	1	0
EVX2	344191	broad.mit.edu	37	2	176947074	176947074	+	Silent	SNP	C	C	T			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	a53ffcc4-1471-4a5a-8f8a-1921eae48392	g.chr2:176947074C>T	ENST00000308618.4	-	2	667	c.531G>A	c.(529-531)gcG>gcA	p.A177A		NM_001080458.1	NP_001073927.1	Q03828	EVX2_HUMAN	even-skipped homeobox 2	177						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			kidney(1)|large_intestine(3)|liver(1)|lung(8)|ovary(3)	16			OV - Ovarian serous cystadenocarcinoma(117;0.0207)|Epithelial(96;0.18)	READ - Rectum adenocarcinoma(9;0.0678)|Colorectal(32;0.115)		AGCCACCCAGCGCCGCGCTCC	0.721000													4	7					0	0	1	0	0
ADAMTS12	81792	broad.mit.edu	37	5	33624444	33624444	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	a53ffcc4-1471-4a5a-8f8a-1921eae48392	g.chr5:33624444C>T	ENST00000504830.1	-	14	2370	c.2035G>A	c.(2035-2037)Gac>Aac	p.D679N	ADAMTS12_ENST00000352040.3_Intron|ADAMTS12_ENST00000504582.1_5'UTR	NM_030955.2	NP_112217.2	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 12	679	Cys-rich.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(7)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(11)|large_intestine(31)|liver(1)|lung(135)|ovary(4)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(5)	216						ATCTCATAGTCACAGCCAACC	0.542000										HNSCC(64;0.19)			29	36					0	0	1	0	0
KBTBD7	84078	broad.mit.edu	37	13	41768338	41768338	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	a53ffcc4-1471-4a5a-8f8a-1921eae48392	g.chr13:41768338C>T	ENST00000379483.3	-	1	364	c.56G>A	c.(55-57)gGg>gAg	p.G19E		NM_032138.4	NP_115514.2	Q8WVZ9	KBTB7_HUMAN	kelch repeat and BTB (POZ) domain containing 7	19							protein binding			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|liver(1)|lung(8)|ovary(4)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	24		Lung NSC(96;0.000105)|Breast(139;0.00715)|Prostate(109;0.0233)|Lung SC(185;0.0367)		all cancers(112;6.21e-09)|Epithelial(112;6.99e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000196)|GBM - Glioblastoma multiforme(144;0.000857)|BRCA - Breast invasive adenocarcinoma(63;0.0669)		GGGCCGCCTCCCACCACGGGG	0.657000													7	118					0	0	1	0	0
GALNT8	26290	broad.mit.edu	37	12	4881631	4881631	+	Missense_Mutation	SNP	A	A	C			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	a53ffcc4-1471-4a5a-8f8a-1921eae48392	g.chr12:4881631A>C	ENST00000252318.2	+	11	2119	c.1782A>C	c.(1780-1782)agA>agC	p.R594S		NM_017417.1	NP_059113.1	Q9NY28	GALT8_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 8 (GalNAc-T8)	594	Ricin B-type lectin.					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(13)|ovary(2)|pancreas(1)|prostate(4)|skin(2)|urinary_tract(1)	35						TCATAAACAGAGATACCAAGC	0.522000													21	57					0	0	1	0	0
OR2L3	391192	broad.mit.edu	37	1	248224693	248224693	+	Missense_Mutation	SNP	A	A	G			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	a53ffcc4-1471-4a5a-8f8a-1921eae48392	g.chr1:248224693A>G	ENST00000359959.3	+	1	710	c.710A>G	c.(709-711)tAc>tGc	p.Y237C	OR2L13_ENST00000366478.2_Intron	NM_001004687.1	NP_001004687.1	Q8NG85	OR2L3_HUMAN	olfactory receptor, family 2, subfamily L, member 3	237					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|endometrium(2)|large_intestine(7)|lung(28)|prostate(1)|skin(1)|urinary_tract(1)	41	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0278)			AAGAAAGCCTACCTGACCTGC	0.473000													130	173					0	0	1	0	0
OC90	729330	broad.mit.edu	37	8	133048637	133048637	+	Silent	SNP	C	C	G			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	a53ffcc4-1471-4a5a-8f8a-1921eae48392	g.chr8:133048637C>G	ENST00000262283.5	-	13	1395	c.1296G>C	c.(1294-1296)ctG>ctC	p.L432L	OC90_ENST00000443356.2_Silent_p.L236L|OC90_ENST00000603859.1_Intron|OC90_ENST00000254627.3_Intron			Q02509	OC90_HUMAN	otoconin 90	236	Phospholipase A2-like 3.				lipid catabolic process|phospholipid metabolic process		calcium ion binding|phospholipase A2 activity			NS(1)|breast(1)|central_nervous_system(3)|endometrium(1)|kidney(1)|large_intestine(3)|lung(23)|ovary(2)|prostate(1)|skin(1)	37	Esophageal squamous(12;0.00693)|Ovarian(258;0.00769)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000805)			AGAGAGTGATCAGTCTGTCAG	0.433000													18	55					0	0	1	0	0
ARID1A	8289	broad.mit.edu	37	1	27100182	27100184	+	In_Frame_Del	DEL	GCA	GCA	-			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr1:27100182_27100184delGCA	ENST00000324856.7	+	16	4349_4351	c.3978_3980delGCA	c.(3976-3981)ccg>cc	p.PQ1326del	ARID1A_ENST00000457599.2_In_Frame_Del_p.PQ1326del|ARID1A_ENST00000374152.2_In_Frame_Del_p.PQ943del|ARID1A_ENST00000540690.1_5'UTR	NM_006015.4	NP_006006.3	O14497	ARI1A_HUMAN	AT rich interactive domain 1A (SWI-like)	1326					androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding	p.Q1327*(1)|p.Q1334delQ(1)	ARID1A/MAST2_ENST00000361297(2)	NS(1)|autonomic_ganglia(1)|biliary_tract(1)|breast(13)|central_nervous_system(6)|cervix(2)|endometrium(56)|haematopoietic_and_lymphoid_tissue(8)|kidney(10)|large_intestine(41)|liver(31)|lung(34)|ovary(130)|pancreas(18)|prostate(8)|skin(9)|stomach(14)|upper_aerodigestive_tract(4)|urinary_tract(24)	411		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		GCTACCCCCCgcagcagcagcag	0.591			"""Mis, N, F, S, D"""		"""clear cell ovarian carcinoma, RCC"""								7	101	---	---	---	---					
TTN	7273	broad.mit.edu	37	2	179414066	179414066	+	Frame_Shift_Del	DEL	T	T	-			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr2:179414066delT	ENST00000589042.1	-	339	92511	c.92287delA	c.(92287-92289)gcfs	p.S30763fs	TTN-AS1_ENST00000586707.1_RNA|TTN_ENST00000460472.2_Frame_Shift_Del_p.S21698fs|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000438095.1_RNA|TTN-AS1_ENST00000592600.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN_ENST00000591111.1_Frame_Shift_Del_p.S29122fs|TTN-AS1_ENST00000456053.1_RNA|TTN-AS1_ENST00000590932.1_RNA|RP11-65L3.2_ENST00000603415.1_RNA|TTN_ENST00000342175.6_Frame_Shift_Del_p.S21890fs|TTN-AS1_ENST00000590807.1_RNA|TTN_ENST00000342992.6_Frame_Shift_Del_p.S28195fs|TTN-AS1_ENST00000586831.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000359218.5_Frame_Shift_Del_p.S21823fs	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	29122	Fibronectin type-III 124.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CATCTTGTGCTTTTCTTTTCT	0.413													29	82	---	---	---	---					
HSPD1P6	645548	broad.mit.edu	37	3	36810381	36810381	+	RNA	DEL	T	T	-			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr3:36810381delT	ENST00000424886.1	-	0	405																											GAGTGAGGCCttttttttttt	0.542													4	7	---	---	---	---					
DRD3	1814	broad.mit.edu	37	3	113849986	113849986	+	Frame_Shift_Del	DEL	G	G	-			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr3:113849986delG	ENST00000383673.2	-	6	1415	c.985delC	c.(985-987)aafs	p.Q329fs	DRD3_ENST00000460779.1_Frame_Shift_Del_p.Q329fs|DRD3_ENST00000295881.7_Frame_Shift_Del_p.Q296fs|DRD3_ENST00000467632.1_Frame_Shift_Del_p.Q329fs	NM_000796.3	NP_000787.2	P35462	DRD3_HUMAN	dopamine receptor D3	329					activation of adenylate cyclase activity by dopamine receptor signaling pathway|arachidonic acid secretion|behavioral response to cocaine|cellular calcium ion homeostasis|circadian regulation of gene expression|G-protein coupled receptor internalization|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|locomotory behavior|musculoskeletal movement, spinal reflex action|negative regulation of blood pressure|negative regulation of oligodendrocyte differentiation|negative regulation of protein kinase B signaling cascade|negative regulation of protein secretion|positive regulation of dopamine receptor signaling pathway|positive regulation of mitosis|prepulse inhibition|regulation of dopamine secretion|response to drug|response to histamine|response to morphine|social behavior|visual learning	integral to plasma membrane	dopamine D3 receptor activity|drug binding			central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(4)|liver(1)|lung(23)|ovary(1)|pancreas(1)|skin(1)	36					Apomorphine(DB00714)|Chlorprothixene(DB01239)|Cocaine(DB00907)|Methotrimeprazine(DB01403)|Olanzapine(DB00334)|Pramipexole(DB00413)|Ropinirole(DB00268)|Ziprasidone(DB00246)	GCCACCATTTGGGTTGCCTTC	0.498													17	54	---	---	---	---					
DRD3	1814	broad.mit.edu	37	3	113850028	113850028	+	Frame_Shift_Del	DEL	G	G	-			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr3:113850028delG	ENST00000383673.2	-	6	1373	c.943delC	c.(943-945)tgfs	p.L315fs	DRD3_ENST00000460779.1_Frame_Shift_Del_p.L315fs|DRD3_ENST00000295881.7_Intron|DRD3_ENST00000467632.1_Frame_Shift_Del_p.L315fs	NM_000796.3	NP_000787.2	P35462	DRD3_HUMAN	dopamine receptor D3	315					activation of adenylate cyclase activity by dopamine receptor signaling pathway|arachidonic acid secretion|behavioral response to cocaine|cellular calcium ion homeostasis|circadian regulation of gene expression|G-protein coupled receptor internalization|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|locomotory behavior|musculoskeletal movement, spinal reflex action|negative regulation of blood pressure|negative regulation of oligodendrocyte differentiation|negative regulation of protein kinase B signaling cascade|negative regulation of protein secretion|positive regulation of dopamine receptor signaling pathway|positive regulation of mitosis|prepulse inhibition|regulation of dopamine secretion|response to drug|response to histamine|response to morphine|social behavior|visual learning	integral to plasma membrane	dopamine D3 receptor activity|drug binding			central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(4)|liver(1)|lung(23)|ovary(1)|pancreas(1)|skin(1)	36					Apomorphine(DB00714)|Chlorprothixene(DB01239)|Cocaine(DB00907)|Methotrimeprazine(DB01403)|Olanzapine(DB00334)|Pramipexole(DB00413)|Ropinirole(DB00268)|Ziprasidone(DB00246)	CGAGGTTGCAGGGGCCCCAGC	0.537													31	104	---	---	---	---					
CTC-338M12.9	0	broad.mit.edu	37	5	180708776	180708777	+	RNA	INS	-	-	G	rs140221514		TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr5:180708776_180708777insG	ENST00000412295.2	+	0	238																											gggcggtaggagggggctggag	0.728													2	4	---	---	---	---					
COL21A1	81578	broad.mit.edu	37	6	56044716	56044716	+	Frame_Shift_Del	DEL	C	C	-			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr6:56044716delC	ENST00000244728.5	-	3	697	c.300delG	c.(298-300)ttfs	p.L100fs	COL21A1_ENST00000535941.1_Frame_Shift_Del_p.L100fs|COL21A1_ENST00000370819.1_Frame_Shift_Del_p.L100fs	NM_030820.3	NP_110447.2	Q96P44	COLA1_HUMAN	collagen, type XXI, alpha 1	100	VWFA.				cell adhesion	collagen|cytoplasm	structural molecule activity			breast(1)|endometrium(1)|kidney(3)|large_intestine(11)|lung(21)|ovary(2)|prostate(2)	41	Lung NSC(77;0.0483)		LUSC - Lung squamous cell carcinoma(124;0.181)			CTGCTGCCGTCAAATGTTCTC	0.463													12	27	---	---	---	---					
SFRP4	6424	broad.mit.edu	37	7	37956011	37956011	+	Frame_Shift_Del	DEL	G	G	-			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr7:37956011delG	ENST00000436072.2	-	1	506	c.129delC	c.(127-129)ccfs	p.P43fs	EPDR1_ENST00000476620.1_Intron	NM_003014.3	NP_003005.2	Q6FHJ7	SFRP4_HUMAN	secreted frizzled-related protein 4	43	FZ.				brain development|cell differentiation|decidualization|embryo development|epithelium development|gonad development|mammary gland involution|menstrual cycle phase|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cell proliferation|negative regulation of JNK cascade|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of sodium-dependent phosphate transport|phosphate ion homeostasis|positive regulation of apoptosis|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of epidermal cell differentiation|positive regulation of gene expression|positive regulation of receptor internalization|vasculature development|Wnt receptor signaling pathway	cell surface|cytoplasm|extracellular space|nucleus	PDZ domain binding|Wnt receptor activity|Wnt-protein binding			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(5)|lung(13)|upper_aerodigestive_tract(2)|urinary_tract(1)	29						GCAGGTGGTTGGGCATCCGCG	0.682													21	73	---	---	---	---					
GLS2	27165	broad.mit.edu	37	12	56868875	56868875	+	Frame_Shift_Del	DEL	T	T	-			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr12:56868875delT	ENST00000311966.4	-	10	1227	c.949delA	c.(949-951)cafs	p.T317fs	GLS2_ENST00000476991.1_5'UTR	NM_013267.2	NP_037399.2	Q9UI32	GLSL_HUMAN	glutaminase 2 (liver, mitochondrial)	317					cellular amino acid biosynthetic process|glutamate secretion|glutamine metabolic process|neurotransmitter secretion	mitochondrial matrix	glutaminase activity|protein binding			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(4)|ovary(1)|stomach(1)|urinary_tract(1)	13					L-Glutamic Acid(DB00142)|L-Glutamine(DB00130)	CGATCCCCTGTTTCCTTCTCT	0.473													64	203	---	---	---	---					
RTL1	388015	broad.mit.edu	37	14	101350670	101350671	+	In_Frame_Ins	INS	-	-	TCT	rs55755518	by1000genomes	TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr14:101350670_101350671insTCT	ENST00000534062.1	-	1	513_514	c.455_456insAGA	c.(454-456)gca>gAGAca	p.152_152A>ET		NM_001134888.2	NP_001128360.1	E9PKS8	E9PKS8_HUMAN	retrotransposon-like 1	152										breast(1)|endometrium(5)|kidney(4)|large_intestine(1)|lung(5)|pancreas(1)|prostate(2)|skin(2)	21						TCTGGTTTTGCTCTTGAGGAGT	0.520													4	2	---	---	---	---					
ALOX12	239	broad.mit.edu	37	17	6913280	6913288	+	In_Frame_Del	DEL	CTGGTATGC	CTGGTATGC	-			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr17:6913280_6913288delCTGGTATGC	ENST00000251535.6	+	13	1700_1708	c.1647_1655delCTGGTATGC	c.(1645-1656)gac>ga	p.DWYA549del	AC027763.2_ENST00000573939.1_Intron|AC027763.2_ENST00000399540.2_Intron|AC027763.2_ENST00000575727.1_Intron|AC027763.2_ENST00000574377.1_Intron|AC027763.2_ENST00000399541.2_Intron|RP11-589P10.7_ENST00000572547.1_RNA	NM_000697.2	NP_000688.2	P18054	LOX12_HUMAN	arachidonate 12-lipoxygenase	549	Lipoxygenase.				anti-apoptosis|cellular component movement|fatty acid oxidation|leukotriene biosynthetic process|positive regulation of cell adhesion|positive regulation of cell growth|positive regulation of cell proliferation|superoxide anion generation	cytosol|sarcolemma	arachidonate 12-lipoxygenase activity|hepoxilin-epoxide hydrolase activity|iron ion binding|lipoxygenase activity|protein binding			breast(2)|central_nervous_system(1)|endometrium(3)|large_intestine(4)|lung(4)|ovary(1)|prostate(3)|urinary_tract(1)	19						TCCAGCTGGACTGGTATGCCTGGGTCCCT	0.560													10	75	---	---	---	---					
TBC1D3P1-DHX40P1	653645	broad.mit.edu	37	17	58090680	58090681	+	RNA	INS	-	-	T			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr17:58090680_58090681insT	ENST00000407042.3	-	0	609																											ACTCTGAATGATTTTTTTTTTT	0.455													2	4	---	---	---	---					
SERPINB11	89778	broad.mit.edu	37	18	61390583	61390584	+	RNA	DEL	CA	CA	-			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	d522702c-a21c-467b-b77c-6ea8717c194e	g.chr18:61390583_61390584delCA	ENST00000544088.1	+	0	1191_1192				SERPINB11_ENST00000538847.1_RNA|SERPINB11_ENST00000536691.1_RNA|SERPINB11_ENST00000382749.5_RNA	NM_080475.2	NP_536723.2	Q96P15	SPB11_HUMAN	serpin peptidase inhibitor, clade B (ovalbumin), member 11 (gene/pseudogene)						regulation of proteolysis	cytoplasm	serine-type endopeptidase inhibitor activity			breast(1)|cervix(1)|kidney(1)|lung(3)	6		Esophageal squamous(42;0.129)				CTTTATAAGGCACACTCATACC	0.515													31	87	---	---	---	---					
TTN	7273	broad.mit.edu	37	2	179414066	179414066	+	Frame_Shift_Del	DEL	T	T	-			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	a53ffcc4-1471-4a5a-8f8a-1921eae48392	g.chr2:179414066delT	ENST00000589042.1	-	339	92511	c.92287delA	c.(92287-92289)gcfs	p.S30763fs	TTN-AS1_ENST00000590932.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000586831.1_RNA|TTN_ENST00000342175.6_Frame_Shift_Del_p.S21890fs|TTN-AS1_ENST00000586707.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000592750.1_RNA|TTN_ENST00000460472.2_Frame_Shift_Del_p.S21698fs|TTN-AS1_ENST00000419746.1_RNA|RP11-65L3.2_ENST00000603415.1_RNA|TTN_ENST00000359218.5_Frame_Shift_Del_p.S21823fs|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000438095.1_RNA|TTN-AS1_ENST00000592600.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN_ENST00000591111.1_Frame_Shift_Del_p.S29122fs|TTN_ENST00000342992.6_Frame_Shift_Del_p.S28195fs|TTN-AS1_ENST00000456053.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	29122	Fibronectin type-III 124.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CATCTTGTGCTTTTCTTTTCT	0.413													29	82	---	---	---	---					
DRD3	1814	broad.mit.edu	37	3	113849986	113849986	+	Frame_Shift_Del	DEL	G	G	-			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	a53ffcc4-1471-4a5a-8f8a-1921eae48392	g.chr3:113849986delG	ENST00000383673.2	-	6	1415	c.985delC	c.(985-987)aafs	p.Q329fs	DRD3_ENST00000467632.1_Frame_Shift_Del_p.Q329fs|DRD3_ENST00000460779.1_Frame_Shift_Del_p.Q329fs|DRD3_ENST00000295881.7_Frame_Shift_Del_p.Q296fs	NM_000796.3	NP_000787.2	P35462	DRD3_HUMAN	dopamine receptor D3	329					activation of adenylate cyclase activity by dopamine receptor signaling pathway|arachidonic acid secretion|behavioral response to cocaine|cellular calcium ion homeostasis|circadian regulation of gene expression|G-protein coupled receptor internalization|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|locomotory behavior|musculoskeletal movement, spinal reflex action|negative regulation of blood pressure|negative regulation of oligodendrocyte differentiation|negative regulation of protein kinase B signaling cascade|negative regulation of protein secretion|positive regulation of dopamine receptor signaling pathway|positive regulation of mitosis|prepulse inhibition|regulation of dopamine secretion|response to drug|response to histamine|response to morphine|social behavior|visual learning	integral to plasma membrane	dopamine D3 receptor activity|drug binding			central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(4)|liver(1)|lung(23)|ovary(1)|pancreas(1)|skin(1)	36					Apomorphine(DB00714)|Chlorprothixene(DB01239)|Cocaine(DB00907)|Methotrimeprazine(DB01403)|Olanzapine(DB00334)|Pramipexole(DB00413)|Ropinirole(DB00268)|Ziprasidone(DB00246)	GCCACCATTTGGGTTGCCTTC	0.498													17	54	---	---	---	---					
DRD3	1814	broad.mit.edu	37	3	113850028	113850028	+	Frame_Shift_Del	DEL	G	G	-			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	a53ffcc4-1471-4a5a-8f8a-1921eae48392	g.chr3:113850028delG	ENST00000383673.2	-	6	1373	c.943delC	c.(943-945)tgfs	p.L315fs	DRD3_ENST00000467632.1_Frame_Shift_Del_p.L315fs|DRD3_ENST00000460779.1_Frame_Shift_Del_p.L315fs|DRD3_ENST00000295881.7_Intron	NM_000796.3	NP_000787.2	P35462	DRD3_HUMAN	dopamine receptor D3	315					activation of adenylate cyclase activity by dopamine receptor signaling pathway|arachidonic acid secretion|behavioral response to cocaine|cellular calcium ion homeostasis|circadian regulation of gene expression|G-protein coupled receptor internalization|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|locomotory behavior|musculoskeletal movement, spinal reflex action|negative regulation of blood pressure|negative regulation of oligodendrocyte differentiation|negative regulation of protein kinase B signaling cascade|negative regulation of protein secretion|positive regulation of dopamine receptor signaling pathway|positive regulation of mitosis|prepulse inhibition|regulation of dopamine secretion|response to drug|response to histamine|response to morphine|social behavior|visual learning	integral to plasma membrane	dopamine D3 receptor activity|drug binding			central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(4)|liver(1)|lung(23)|ovary(1)|pancreas(1)|skin(1)	36					Apomorphine(DB00714)|Chlorprothixene(DB01239)|Cocaine(DB00907)|Methotrimeprazine(DB01403)|Olanzapine(DB00334)|Pramipexole(DB00413)|Ropinirole(DB00268)|Ziprasidone(DB00246)	CGAGGTTGCAGGGGCCCCAGC	0.537													31	104	---	---	---	---					
COL21A1	81578	broad.mit.edu	37	6	56044716	56044716	+	Frame_Shift_Del	DEL	C	C	-			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	a53ffcc4-1471-4a5a-8f8a-1921eae48392	g.chr6:56044716delC	ENST00000244728.5	-	3	697	c.300delG	c.(298-300)ttfs	p.L100fs	COL21A1_ENST00000535941.1_Frame_Shift_Del_p.L100fs|COL21A1_ENST00000370819.1_Frame_Shift_Del_p.L100fs	NM_030820.3	NP_110447.2	Q96P44	COLA1_HUMAN	collagen, type XXI, alpha 1	100	VWFA.				cell adhesion	collagen|cytoplasm	structural molecule activity			breast(1)|endometrium(1)|kidney(3)|large_intestine(11)|lung(21)|ovary(2)|prostate(2)	41	Lung NSC(77;0.0483)		LUSC - Lung squamous cell carcinoma(124;0.181)			CTGCTGCCGTCAAATGTTCTC	0.463													12	27	---	---	---	---					
SFRP4	6424	broad.mit.edu	37	7	37956011	37956011	+	Frame_Shift_Del	DEL	G	G	-			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	a53ffcc4-1471-4a5a-8f8a-1921eae48392	g.chr7:37956011delG	ENST00000436072.2	-	1	506	c.129delC	c.(127-129)ccfs	p.P43fs	EPDR1_ENST00000476620.1_Intron	NM_003014.3	NP_003005.2	Q6FHJ7	SFRP4_HUMAN	secreted frizzled-related protein 4	43	FZ.				brain development|cell differentiation|decidualization|embryo development|epithelium development|gonad development|mammary gland involution|menstrual cycle phase|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cell proliferation|negative regulation of JNK cascade|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of sodium-dependent phosphate transport|phosphate ion homeostasis|positive regulation of apoptosis|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of epidermal cell differentiation|positive regulation of gene expression|positive regulation of receptor internalization|vasculature development|Wnt receptor signaling pathway	cell surface|cytoplasm|extracellular space|nucleus	PDZ domain binding|Wnt receptor activity|Wnt-protein binding			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(5)|lung(13)|upper_aerodigestive_tract(2)|urinary_tract(1)	29						GCAGGTGGTTGGGCATCCGCG	0.682													21	73	---	---	---	---					
DDX6	1656	broad.mit.edu	37	11	118629613	118629614	+	Splice_Site	INS	-	-	G			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	a53ffcc4-1471-4a5a-8f8a-1921eae48392	g.chr11:118629613_118629614insG	ENST00000264018.4	-	9	1170		c.e9-2		DDX6_ENST00000534980.1_Splice_Site|DDX6_ENST00000526070.2_Splice_Site	NM_004397.4	NP_004388.2	P26196	DDX6_HUMAN	DEAD (Asp-Glu-Ala-Asp) box helicase 6						exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	cytoplasmic mRNA processing body|cytosol|RNA-induced silencing complex|stress granule	ATP binding|ATP-dependent helicase activity|protein binding|RNA binding|RNA helicase activity			NS(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(1)|ovary(1)|prostate(1)	13	all_hematologic(175;0.0839)	Renal(330;0.0183)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)|Hepatocellular(160;0.0893)|Breast(348;0.0979)|all_hematologic(192;0.103)		OV - Ovarian serous cystadenocarcinoma(223;3.39e-06)|BRCA - Breast invasive adenocarcinoma(274;3.4e-05)|Colorectal(284;0.0377)		ATGGGAATTCTGGGGGGGGAGC	0.426			T	IGH@	B-NHL								30	115	---	---	---	---					
GLS2	27165	broad.mit.edu	37	12	56868875	56868875	+	Frame_Shift_Del	DEL	T	T	-			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	a53ffcc4-1471-4a5a-8f8a-1921eae48392	g.chr12:56868875delT	ENST00000311966.4	-	10	1227	c.949delA	c.(949-951)cafs	p.T317fs	GLS2_ENST00000476991.1_5'UTR	NM_013267.2	NP_037399.2	Q9UI32	GLSL_HUMAN	glutaminase 2 (liver, mitochondrial)	317					cellular amino acid biosynthetic process|glutamate secretion|glutamine metabolic process|neurotransmitter secretion	mitochondrial matrix	glutaminase activity|protein binding			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(4)|ovary(1)|stomach(1)|urinary_tract(1)	13					L-Glutamic Acid(DB00142)|L-Glutamine(DB00130)	CGATCCCCTGTTTCCTTCTCT	0.473													64	203	---	---	---	---					
DHX38	9785	broad.mit.edu	37	16	72138456	72138457	+	Frame_Shift_Ins	INS	-	-	T			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	a53ffcc4-1471-4a5a-8f8a-1921eae48392	g.chr16:72138456_72138457insT	ENST00000268482.3	+	15	2591_2592	c.2082_2083insT	c.(2080-2085)gcttttfs	p.AF694fs	DHX38_ENST00000536867.1_Intron	NM_014003.3	NP_054722.2	Q92620	PRP16_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 38	694	Helicase ATP-binding.				mRNA 3'-end processing|mRNA export from nucleus|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	catalytic step 2 spliceosome|nucleoplasm	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			endometrium(5)|kidney(1)|large_intestine(16)|lung(15)|pancreas(1)|prostate(2)|skin(5)|stomach(2)|upper_aerodigestive_tract(1)	48		Ovarian(137;0.125)				AGTTTGCTGCCTTTTTTGGGAA	0.564													29	78	---	---	---	---					
ALOX12	239	broad.mit.edu	37	17	6913280	6913288	+	In_Frame_Del	DEL	CTGGTATGC	CTGGTATGC	-			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	a53ffcc4-1471-4a5a-8f8a-1921eae48392	g.chr17:6913280_6913288delCTGGTATGC	ENST00000251535.6	+	13	1700_1708	c.1647_1655delCTGGTATGC	c.(1645-1656)gac>ga	p.DWYA549del	AC027763.2_ENST00000399540.2_Intron|AC027763.2_ENST00000574377.1_Intron|AC027763.2_ENST00000399541.2_Intron|AC027763.2_ENST00000573939.1_Intron|RP11-589P10.7_ENST00000572547.1_RNA|AC027763.2_ENST00000575727.1_Intron	NM_000697.2	NP_000688.2	P18054	LOX12_HUMAN	arachidonate 12-lipoxygenase	549	Lipoxygenase.				anti-apoptosis|cellular component movement|fatty acid oxidation|leukotriene biosynthetic process|positive regulation of cell adhesion|positive regulation of cell growth|positive regulation of cell proliferation|superoxide anion generation	cytosol|sarcolemma	arachidonate 12-lipoxygenase activity|hepoxilin-epoxide hydrolase activity|iron ion binding|lipoxygenase activity|protein binding			breast(2)|central_nervous_system(1)|endometrium(3)|large_intestine(4)|lung(4)|ovary(1)|prostate(3)|urinary_tract(1)	19						TCCAGCTGGACTGGTATGCCTGGGTCCCT	0.560													10	75	---	---	---	---					
SERPINB11	89778	broad.mit.edu	37	18	61390583	61390584	+	RNA	DEL	CA	CA	-			TCGA-44-7659-01A-11D-2063-08	TCGA-44-7659-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4daa1421-462e-467b-bd12-1998736406ae	a53ffcc4-1471-4a5a-8f8a-1921eae48392	g.chr18:61390583_61390584delCA	ENST00000544088.1	+	0	1191_1192				SERPINB11_ENST00000536691.1_RNA|SERPINB11_ENST00000382749.5_RNA|SERPINB11_ENST00000538847.1_RNA	NM_080475.2	NP_536723.2	Q96P15	SPB11_HUMAN	serpin peptidase inhibitor, clade B (ovalbumin), member 11 (gene/pseudogene)						regulation of proteolysis	cytoplasm	serine-type endopeptidase inhibitor activity			breast(1)|cervix(1)|kidney(1)|lung(3)	6		Esophageal squamous(42;0.129)				CTTTATAAGGCACACTCATACC	0.515													31	87	---	---	---	---