Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
CEP128	145508	broad.mit.edu	37	14	81259233	81259233	+	Silent	SNP	C	C	T			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr14:81259233C>T	ENST00000555265.1	-	14	1806	c.1431G>A	c.(1429-1431)aaG>aaA	p.K477K	CEP128_ENST00000281129.3_Silent_p.K477K			Q6ZU80	CE128_HUMAN	centrosomal protein 128kDa	477						centriole|spindle pole				NS(1)|breast(3)|central_nervous_system(2)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(22)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	51						CTTCCCTCCTCTTCTCCGCCT	0.512000													8	98					0	0	0.038147	0	0
ZNF536	9745	broad.mit.edu	37	19	31039643	31039643	+	Silent	SNP	C	C	A			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr19:31039643C>A	ENST00000355537.3	+	4	3264	c.3117C>A	c.(3115-3117)gtC>gtA	p.V1039V		NM_014717.1	NP_055532.1	O15090	ZN536_HUMAN	zinc finger protein 536	1039					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			NS(3)|breast(6)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|lung(119)|ovary(7)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(3)	182	Esophageal squamous(110;0.0834)					GGGTCACAGTCAACTGCAAAG	0.542000													6	35					3.59834e-05	5.32481e-05	0.021553	1	0
GHR	2690	broad.mit.edu	37	5	42689086	42689086	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr5:42689086G>T	ENST00000230882.4	+	4	421	c.231G>T	c.(229-231)aaG>aaT	p.K77N	GHR_ENST00000357703.3_Missense_Mutation_p.K55N|GHR_ENST00000537449.1_Intron	NM_000163.4|NM_001242399.2|NM_001242400.2|NM_001242401.3|NM_001242402.2|NM_001242403.2|NM_001242404.2|NM_001242405.2|NM_001242406.2	NP_000154.1|NP_001229328.1|NP_001229329.1|NP_001229330.1|NP_001229331.1|NP_001229332.1|NP_001229333.1|NP_001229334.1|NP_001229335.1	P10912	GHR_HUMAN	growth hormone receptor	77					2-oxoglutarate metabolic process|activation of JAK2 kinase activity|activation of MAPK activity|allantoin metabolic process|citrate metabolic process|creatine metabolic process|creatinine metabolic process|endocytosis|fatty acid metabolic process|growth hormone receptor signaling pathway|insulin-like growth factor receptor signaling pathway|isoleucine metabolic process|JAK-STAT cascade|multicellular organismal metabolic process|oxaloacetate metabolic process|positive regulation of multicellular organism growth|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of tyrosine phosphorylation of Stat5 protein|receptor internalization|response to cycloheximide|response to estradiol stimulus|succinate metabolic process|taurine metabolic process|valine metabolic process	cell surface|extracellular space|growth hormone receptor complex|integral to plasma membrane	growth factor binding|peptide hormone binding|proline-rich region binding|protein homodimerization activity|protein kinase binding			NS(2)|endometrium(2)|kidney(3)|large_intestine(8)|lung(19)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	39		Myeloproliferative disorder(839;0.00878)			Pegvisomant(DB00082)|Somatropin recombinant(DB00052)	ATGGTACAAAGAACCTAGGAC	0.458000													11	111					0.00010058	0.000143058	0.093190	1	0
TTN	7273	broad.mit.edu	37	2	179587009	179587009	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr2:179587009G>C	ENST00000589042.1	-	77	22729	c.22505C>G	c.(22504-22506)tCt>tGt	p.S7502C	TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000359218.5_Intron|TTN_ENST00000342175.6_Intron|TTN_ENST00000460472.2_Intron|TTN_ENST00000342992.6_Missense_Mutation_p.S6258C|TTN_ENST00000591111.1_Missense_Mutation_p.S7185C	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	7185	Ig-like 57.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCTAGCACTAGAAGATGCTGT	0.413000													4	73					0	0	0.009096	0	0
SGPL1	8879	broad.mit.edu	37	10	72633294	72633294	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr10:72633294T>A	ENST00000373202.3	+	12	1446	c.1246T>A	c.(1246-1248)Tat>Aat	p.Y416N		NM_003901.3	NP_003892.2	O95470	SGPL1_HUMAN	sphingosine-1-phosphate lyase 1	416					apoptosis|carboxylic acid metabolic process|ceramide metabolic process|sphingolipid catabolic process	integral to endoplasmic reticulum membrane	carboxy-lyase activity|pyridoxal phosphate binding|sphinganine-1-phosphate aldolase activity			large_intestine(4)	4					Pyridoxal Phosphate(DB00114)	TGAGAACGGCTATGTTGAAGC	0.527000													5	107					0	0	0.029380	0	0
OR5F1	338674	broad.mit.edu	37	11	55761734	55761734	+	Missense_Mutation	SNP	T	T	A	rs140060499	byFrequency	TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr11:55761734T>A	ENST00000278409.1	-	1	367	c.368A>T	c.(367-369)tAt>tTt	p.Y123F		NM_003697.1	NP_003688.1	O95221	OR5F1_HUMAN	olfactory receptor, family 5, subfamily F, member 1	123					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(6)|kidney(1)|large_intestine(11)|liver(1)|lung(33)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	58	Esophageal squamous(21;0.00448)					TATGGCCGCATACCTGTCATA	0.502000													12	95					0	0	0.119110	0	0
POT1	25913	broad.mit.edu	37	7	124510999	124510999	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr7:124510999T>A	ENST00000357628.3	-	7	819	c.221A>T	c.(220-222)aAa>aTa	p.K74I	POT1_ENST00000393329.1_Intron	NM_015450.2	NP_056265.2	Q9NUX5	POTE1_HUMAN	protection of telomeres 1	74					DNA duplex unwinding|negative regulation of telomere maintenance via telomerase|positive regulation of DNA strand elongation|positive regulation of helicase activity|positive regulation of telomerase activity|positive regulation of telomere maintenance via telomerase|telomere capping|telomere formation via telomerase|telomere maintenance via telomerase	nuclear telomere cap complex|nucleoplasm	DEAD/H-box RNA helicase binding|single-stranded telomeric DNA binding|telomerase inhibitor activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(4)|liver(1)|lung(23)|ovary(1)|prostate(1)|skin(3)|stomach(1)|urinary_tract(1)	47						ATCTCCATTTTTATAAATTAT	0.333000													5	48					0	0	0.014758	0	0
TANC2	26115	broad.mit.edu	37	17	61391823	61391823	+	Nonsense_Mutation	SNP	G	G	T			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr17:61391823G>T	ENST00000424789.2	+	8	1016	c.1012G>T	c.(1012-1014)Gag>Tag	p.E338*	AC037445.1_ENST00000581421.1_RNA|TANC2_ENST00000389520.4_Nonsense_Mutation_p.E338*	NM_025185.3	NP_079461.2	Q9HCD6	TANC2_HUMAN	tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2	338							binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(15)|ovary(2)|upper_aerodigestive_tract(3)	44						CATCACTACAGAGTCAGTGTT	0.458000													12	103					0.000151284	0.000214137	0.105934	1	0
NPHS2	7827	broad.mit.edu	37	1	179526327	179526327	+	Silent	SNP	G	G	A			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr1:179526327G>A	ENST00000367615.4	-	5	641	c.573C>T	c.(571-573)gcC>gcT	p.A191A	NPHS2_ENST00000367616.4_Intron	NM_014625.2	NP_055440.1	Q9NP85	PODO_HUMAN	nephrosis 2, idiopathic, steroid-resistant (podocin)	191					excretion	integral to plasma membrane	protein binding			NS(1)|endometrium(1)|large_intestine(3)|lung(10)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)	20						AGTAGCAAATGGCATCTATCT	0.428000													3	71					0	0	0.021553	0	0
MBL2	4153	broad.mit.edu	37	10	54531274	54531274	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr10:54531274G>A	ENST00000373968.3	-	1	186	c.122C>T	c.(121-123)cCa>cTa	p.P41L		NM_000242.2	NP_000233.1	P11226	MBL2_HUMAN	mannose-binding lectin (protein C) 2, soluble	41	Cys-rich.				acute-phase response|complement activation, classical pathway|complement activation, lectin pathway|defense response to Gram-positive bacterium|negative regulation of growth of symbiont in host|opsonization|response to oxidative stress	collagen|extracellular space	bacterial cell surface binding|calcium-dependent protein binding|eukaryotic cell surface binding|mannose binding|receptor binding			breast(1)|endometrium(2)|lung(12)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	21						GTTGATGCCTGGAGAGCTACA	0.542000													4	79					0	0	0.029380	0	0
SI	6476	broad.mit.edu	37	3	164748533	164748533	+	Silent	SNP	T	T	C			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr3:164748533T>C	ENST00000264382.3	-	25	2921	c.2859A>G	c.(2857-2859)caA>caG	p.Q953Q		NM_001041.3	NP_001032.2	P14410	SUIS_HUMAN	sucrase-isomaltase (alpha-glucosidase)	953	Isomaltase.|P-type 2.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			NS(4)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(6)|kidney(10)|large_intestine(18)|lung(124)|ovary(9)|pancreas(1)|prostate(6)|skin(6)|upper_aerodigestive_tract(16)|urinary_tract(1)	218		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	GTGTGCACTTTTGTTCAGTTG	0.313000										HNSCC(35;0.089)			8	96					0	0	0.058154	0	0
LRP1B	53353	broad.mit.edu	37	2	141665553	141665553	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr2:141665553G>T	ENST00000389484.3	-	22	4384	c.3413C>A	c.(3412-3414)cCa>cAa	p.P1138Q		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	1138	LDL-receptor class A 10.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding	p.P1138L(1)		NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		ATGCTTGGGTGGTCCACACAA	0.463000										TSP Lung(27;0.18)			6	93					0.0215528	0.0244766	0.021553	1	0
ZNF85	7639	broad.mit.edu	37	19	21132799	21132799	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr19:21132799G>T	ENST00000601023.1	+	2	1948	c.1302G>T	c.(1300-1302)tgG>tgT	p.W434C	ZNF85_ENST00000345030.6_Missense_Mutation_p.W460C|ZNF85_ENST00000328178.8_Missense_Mutation_p.W493C			Q03923	ZNF85_HUMAN	zinc finger protein 85	493						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			breast(1)|central_nervous_system(1)|large_intestine(5)|lung(10)|ovary(1)|prostate(2)	20						GTTTTAAATGGCCCTCAACCC	0.358000													4	28					0.00024832	0.000335289	0.009096	1	0
FLG2	388698	broad.mit.edu	37	1	152328290	152328290	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr1:152328290A>G	ENST00000388718.5	-	3	2044	c.1972T>C	c.(1972-1974)Tat>Cat	p.Y658H	FLG-AS1_ENST00000445097.1_RNA|FLG-AS1_ENST00000392688.2_RNA	NM_001014342.2	NP_001014364.1	Q5D862	FILA2_HUMAN	filaggrin family member 2	658	Ser-rich.						calcium ion binding|structural molecule activity			NS(2)|breast(7)|cervix(3)|endometrium(11)|kidney(9)|large_intestine(24)|liver(1)|lung(85)|ovary(12)|pancreas(1)|prostate(6)|skin(17)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(5)	188	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CCTGATCCATATTGGCCAAAG	0.493000													11	271					0	0	0.093190	0	0
OTOF	9381	broad.mit.edu	37	2	26693553	26693553	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr2:26693553C>G	ENST00000272371.2	-	32	4057	c.3931G>C	c.(3931-3933)Ggc>Cgc	p.G1311R	OTOF_ENST00000338581.6_Missense_Mutation_p.G544R|OTOF_ENST00000402415.3_Missense_Mutation_p.G621R|OTOF_ENST00000403946.3_Missense_Mutation_p.G1311R|OTOF_ENST00000339598.3_Missense_Mutation_p.G544R	NM_194248.2	NP_919224.1	Q9HC10	OTOF_HUMAN	otoferlin	1311					cellular membrane fusion|sensory perception of sound|synaptic vesicle exocytosis	basolateral plasma membrane|cell junction|cytosol|endoplasmic reticulum membrane|integral to membrane|membrane fraction|synaptic vesicle membrane	calcium ion binding			NS(1)|autonomic_ganglia(1)|breast(9)|central_nervous_system(4)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(14)|lung(35)|ovary(8)|pancreas(1)|prostate(5)|skin(5)|stomach(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	106	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TCCGCAGTGCCcttcttcttc	0.577000													4	37					0	0	0.009096	0	0
MYH1	4619	broad.mit.edu	37	17	10400674	10400674	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr17:10400674C>G	ENST00000226207.5	-	32	4555	c.4461G>C	c.(4459-4461)aaG>aaC	p.K1487N	CTC-297N7.7_ENST00000581304.1_RNA|CTC-297N7.7_ENST00000587182.1_RNA|CTC-297N7.7_ENST00000399342.2_RNA	NM_005963.3	NP_005954.3	P12882	MYH1_HUMAN	myosin, heavy chain 1, skeletal muscle, adult	1487						muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity	p.K1487N(1)		NS(7)|breast(4)|central_nervous_system(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(22)|lung(78)|ovary(11)|pancreas(1)|prostate(3)|skin(13)|upper_aerodigestive_tract(4)|urinary_tract(5)	176						CATTCTTAATCTTAAATAGTT	0.368000													6	47					0	0	0.021553	0	0
DCAF12L2	340578	broad.mit.edu	37	X	125298905	125298905	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chrX:125298905G>T	ENST00000538699.1	-	2	1083	c.1003C>A	c.(1003-1005)Cgc>Agc	p.R335S	DCAF12L2_ENST00000360028.2_Missense_Mutation_p.R335S	NM_001013628.2	NP_001013650.1	Q5VW00	DC122_HUMAN	DDB1 and CUL4 associated factor 12-like 2	335								p.R335C(2)		NS(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(11)|lung(36)|ovary(2)|pancreas(1)|skin(2)|upper_aerodigestive_tract(3)	64						TGGCGCTGGCGCGGATCCAGG	0.627000													4	71					0.00116845	0.00148205	0.021553	1	0
OR2AK2	391191	broad.mit.edu	37	1	248128876	248128876	+	Silent	SNP	C	C	A			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr1:248128876C>A	ENST00000366480.3	+	1	342	c.243C>A	c.(241-243)ctC>ctA	p.L81L	OR2L13_ENST00000366478.2_Intron	NM_001004491.1	NP_001004491.1	Q8NG84	O2AK2_HUMAN	olfactory receptor, family 2, subfamily AK, member 2	81					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(2)|lung(25)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	36	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0152)			TCAGTCAGCTCTCCATCGTTG	0.478000													15	221					0.000422831	0.000568301	0.146539	1	0
MGAT3	4248	broad.mit.edu	37	22	39884033	39884033	+	Silent	SNP	G	G	A			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr22:39884033G>A	ENST00000341184.6	+	2	896	c.681G>A	c.(679-681)gaG>gaA	p.E227E		NM_001098270.1|NM_002409.4	NP_001091740.1|NP_002400.3	Q09327	MGAT3_HUMAN	mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase	227					post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	beta-1,4-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity			endometrium(4)|kidney(1)|large_intestine(5)|lung(12)|prostate(1)|skin(1)	24	Melanoma(58;0.04)					GCTTCCACGAGCTGGGCGACG	0.647000													4	11					0	0	0.021553	0	0
PTCD1	26024	broad.mit.edu	37	7	99031021	99031021	+	Silent	SNP	C	C	A			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr7:99031021C>A	ENST00000292478.4	-	3	724	c.474G>T	c.(472-474)ctG>ctT	p.L158L	ATP5J2-PTCD1_ENST00000413834.1_Silent_p.L207L|PTCD1_ENST00000555673.1_Silent_p.L207L|PTCD1_ENST00000485746.1_5'UTR	NM_015545.3	NP_056360.2			pentatricopeptide repeat domain 1											endometrium(5)|large_intestine(3)|lung(16)|ovary(2)|skin(1)	27	all_cancers(62;2.54e-08)|all_epithelial(64;2.55e-09)|Lung NSC(181;0.0053)|all_lung(186;0.00895)|Esophageal squamous(72;0.0166)		STAD - Stomach adenocarcinoma(171;0.215)			GCCTCTCAAACAGGTCCAGGG	0.607000													6	91					0.0293803	0.0327317	0.029380	1	0
ZFHX4	79776	broad.mit.edu	37	8	77616704	77616704	+	Silent	SNP	A	A	T			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr8:77616704A>T	ENST00000521891.2	+	2	829	c.381A>T	c.(379-381)ctA>ctT	p.L127L	ZFHX4_ENST00000455469.2_Silent_p.L127L|ZFHX4_ENST00000518282.1_Silent_p.L127L|ZFHX4_ENST00000517683.1_Intron|ZFHX4_ENST00000050961.6_Silent_p.L127L	NM_024721.4	NP_078997.4	Q86UP3	ZFHX4_HUMAN	zinc finger homeobox 4	127						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(3)|breast(11)|central_nervous_system(1)|endometrium(36)|haematopoietic_and_lymphoid_tissue(2)|kidney(15)|large_intestine(66)|liver(2)|lung(245)|ovary(11)|pancreas(3)|prostate(11)|skin(7)|upper_aerodigestive_tract(13)|urinary_tract(6)	432			BRCA - Breast invasive adenocarcinoma(89;0.0895)			TGGAAAATCTAACAGGGGAGA	0.488000										HNSCC(33;0.089)			21	165					0	0	0.055883	0	0
PLEKHM3	389072	broad.mit.edu	37	2	208866199	208866199	+	Silent	SNP	T	T	A			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr2:208866199T>A	ENST00000457206.1	-	2	592	c.165A>T	c.(163-165)acA>acT	p.T55T	PLEKHM3_ENST00000427836.2_Silent_p.T55T|PLEKHM3_ENST00000389247.4_Silent_p.T55T			Q6ZWE6	PKHM3_HUMAN	pleckstrin homology domain containing, family M, member 3	55					intracellular signal transduction		metal ion binding			central_nervous_system(1)|cervix(1)|endometrium(2)|large_intestine(1)|lung(9)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	19						CACCATTGTCTGTTATGTTAC	0.483000													7	156					0	0	0.029380	0	0
GKN1	56287	broad.mit.edu	37	2	69204659	69204659	+	Silent	SNP	A	A	T			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr2:69204659A>T	ENST00000377938.2	+	2	150	c.87A>T	c.(85-87)ctA>ctT	p.L29L		NM_019617.3	NP_062563.3	Q9NS71	GKN1_HUMAN	gastrokine 1	29					digestion|positive regulation of cell division	extracellular region				breast(2)|large_intestine(4)|lung(5)	11						GAGTCTTTCTAGCTCCTGCCC	0.373000													12	79					0	0	0.132662	0	0
TLK2	11011	broad.mit.edu	37	17	60650587	60650587	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr17:60650587G>T	ENST00000582809.1	+	13	1236	c.533G>T	c.(532-534)aGg>aTg	p.R178M	TLK2_ENST00000343388.7_Missense_Mutation_p.R295M|TLK2_ENST00000346027.5_Missense_Mutation_p.R327M|TLK2_ENST00000326270.9_Missense_Mutation_p.R327M|TLK2_ENST00000542523.1_Missense_Mutation_p.R295M			Q86UE8	TLK2_HUMAN	tousled-like kinase 2	327					cell cycle|chromatin modification|intracellular signal transduction|regulation of chromatin assembly or disassembly|response to DNA damage stimulus	nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(10)|kidney(4)|large_intestine(6)|liver(2)|lung(10)|prostate(1)|stomach(1)|urinary_tract(1)	39						CAACAGGAAAGGATAAATTCA	0.428000													3	37					0.004672	0.0056566	0.115264	1	0
SPATA31D1	389763	broad.mit.edu	37	9	84607291	84607291	+	Missense_Mutation	SNP	T	T	G			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr9:84607291T>G	ENST00000344803.2	+	4	1953	c.1906T>G	c.(1906-1908)Ttg>Gtg	p.L636V		NM_001001670.2	NP_001001670.1			SPATA31 subfamily D, member 1																		GCAGGAAAGTTTGTGGGGCTT	0.478000													4	97					0	0	0.009096	0	0
DOCK4	9732	broad.mit.edu	37	7	111418396	111418396	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr7:111418396C>A	ENST00000428084.1	-	36	3887	c.3615G>T	c.(3613-3615)gaG>gaT	p.E1205D	DOCK4_ENST00000494651.2_Missense_Mutation_p.E79D|DOCK4_ENST00000437633.1_Missense_Mutation_p.E1196D			Q8N1I0	DOCK4_HUMAN	dedicator of cytokinesis 4	1196	DHR-2.				cell chemotaxis	cytosol|endomembrane system|membrane|stereocilium	GTP binding|guanyl-nucleotide exchange factor activity|PDZ domain binding|Rac GTPase activator activity|Rac GTPase binding|receptor tyrosine kinase binding|SH3 domain binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(4)|kidney(4)|large_intestine(13)|lung(31)|ovary(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(4)	72		Acute lymphoblastic leukemia(1;0.0441)				TATACATCTCCTCCTTGTTCA	0.393000													6	127					0.00198382	0.00247344	0.029380	1	0
TMCO4	255104	broad.mit.edu	37	1	20063897	20063897	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr1:20063897T>A	ENST00000294543.6	-	13	1473	c.1232A>T	c.(1231-1233)tAc>tTc	p.Y411F	TMCO4_ENST00000489814.1_5'UTR|TMCO4_ENST00000375127.1_Missense_Mutation_p.Y411F|TMCO4_ENST00000375122.2_Missense_Mutation_p.Y371F	NM_181719.4	NP_859070.3	Q5TGY1	TMCO4_HUMAN	transmembrane and coiled-coil domains 4	411						integral to membrane				biliary_tract(1)|breast(2)|endometrium(2)|kidney(1)|lung(11)|skin(1)|upper_aerodigestive_tract(1)	19		Colorectal(325;0.000147)|Renal(390;0.000469)|all_lung(284;0.00519)|Breast(348;0.00526)|Lung NSC(340;0.00544)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0439)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00708)|COAD - Colon adenocarcinoma(152;2.28e-05)|BRCA - Breast invasive adenocarcinoma(304;5.8e-05)|Kidney(64;0.000367)|GBM - Glioblastoma multiforme(114;0.000377)|KIRC - Kidney renal clear cell carcinoma(64;0.00459)|STAD - Stomach adenocarcinoma(196;0.0072)|READ - Rectum adenocarcinoma(331;0.0862)|Lung(427;0.223)		CAGACAGAAGTAGATGACTCT	0.517000													7	84					0	0	0.058154	0	0
RAB38	23682	broad.mit.edu	37	11	87882916	87882916	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr11:87882916A>T	ENST00000243662.6	-	2	492	c.410T>A	c.(409-411)aTg>aAg	p.M137K		NM_022337.2	NP_071732.1	P57729	RAB38_HUMAN	RAB38, member RAS oncogene family	137					protein transport|small GTPase mediated signal transduction	melanosome|plasma membrane	GTP binding|GTPase activity			large_intestine(2)|lung(7)|prostate(1)|upper_aerodigestive_tract(1)	11		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.0123)				GCCATTGTTCATGAGCACATC	0.428000													16	162					0	0	0.033300	0	0
AKR1B10	57016	broad.mit.edu	37	7	134222956	134222956	+	Missense_Mutation	SNP	G	G	T	rs149850087		TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr7:134222956G>T	ENST00000359579.4	+	8	1072	c.752G>T	c.(751-753)cGt>cTt	p.R251L		NM_020299.4	NP_064695.3	O60218	AK1BA_HUMAN	aldo-keto reductase family 1, member B10 (aldose reductase)	251					cellular aldehyde metabolic process|digestion|steroid metabolic process	cytoplasm	aldo-keto reductase (NADP) activity|protein binding			NS(1)|central_nervous_system(1)|kidney(1)|large_intestine(3)|lung(9)|skin(5)	20						GTTCTGATCCGTTTCCATATC	0.493000													8	153					0.0381472	0.0423376	0.038147	1	0
SLC7A4	6545	broad.mit.edu	37	22	21384605	21384605	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr22:21384605G>T	ENST00000382932.2	-	3	1085	c.1018C>A	c.(1018-1020)Ctg>Atg	p.L340M	SLC7A4_ENST00000403586.1_Missense_Mutation_p.L340M	NM_004173.2	NP_004164.2	O43246	CTR4_HUMAN	solute carrier family 7, member 4	340					cellular amino acid metabolic process	integral to membrane	basic amino acid transmembrane transporter activity			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(7)|ovary(1)|prostate(2)	18	all_cancers(11;2.85e-22)|Lung NSC(8;4.21e-14)|all_lung(8;6.08e-13)|Melanoma(16;0.000465)|Ovarian(15;0.0028)|Colorectal(54;0.0968)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.000204)|Lung(15;0.00494)|Epithelial(17;0.195)		L-Arginine(DB00125)|L-Lysine(DB00123)|L-Ornithine(DB00129)	ATGCGTGGCAGGGAGAAGAGG	0.652000													3	13					0.115264	0.125548	0.115264	1	0
DOPEY1	23033	broad.mit.edu	37	6	83846908	83846908	+	Silent	SNP	C	C	A			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr6:83846908C>A	ENST00000349129.2	+	21	3407	c.3147C>A	c.(3145-3147)ctC>ctA	p.L1049L	DOPEY1_ENST00000369739.3_Silent_p.L1040L|DOPEY1_ENST00000237163.5_Silent_p.L1030L	NM_015018.3	NP_055833.2	Q5JWR5	DOP1_HUMAN	dopey family member 1	1049					protein transport					breast(4)|central_nervous_system(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(16)|ovary(5)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)	67		all_cancers(76;2.29e-06)|Acute lymphoblastic leukemia(125;3.41e-06)|all_hematologic(105;0.000865)|all_epithelial(107;0.00203)		BRCA - Breast invasive adenocarcinoma(397;0.053)		AAGTACAACTCATCACATCAA	0.323000													4	47					0.00909568	0.0106177	0.009096	1	0
LRRC16B	90668	broad.mit.edu	37	14	24538410	24538410	+	Silent	SNP	C	C	T			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr14:24538410C>T	ENST00000342740.5	+	39	4201	c.4047C>T	c.(4045-4047)tcC>tcT	p.S1349S	LRRC16B_ENST00000334420.7_Silent_p.S402S	NM_138360.3	NP_612369.3	Q8ND23	LR16B_HUMAN	leucine rich repeat containing 16B	1349										breast(3)|central_nervous_system(2)|cervix(3)|endometrium(7)|kidney(1)|large_intestine(9)|liver(1)|lung(15)|ovary(2)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(4)	52				GBM - Glioblastoma multiforme(265;0.019)		GGGCACAGTCCTGTGACAAGC	0.612000													4	8					0	0	0.009096	0	0
MED7	9443	broad.mit.edu	37	5	156566062	156566062	+	Silent	SNP	T	T	A			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr5:156566062T>A	ENST00000286317.5	-	2	762	c.381A>T	c.(379-381)cgA>cgT	p.R127R	MED7_ENST00000420343.1_Silent_p.R127R	NM_004270.4	NP_004261.1	O43513	MED7_HUMAN	mediator complex subunit 7	127					regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex|transcription factor complex	protein binding|transcription coactivator activity			kidney(1)|large_intestine(1)|lung(3)|urinary_tract(2)	7	Renal(175;0.00212)	Medulloblastoma(196;0.0354)|all_neural(177;0.0999)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			CTTGGTGGGGTCGGTATTCAT	0.418000													6	43					0	0	0.021553	0	0
ZFHX4	79776	broad.mit.edu	37	8	77617862	77617862	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr8:77617862T>A	ENST00000521891.2	+	2	1987	c.1539T>A	c.(1537-1539)agT>agA	p.S513R	ZFHX4_ENST00000455469.2_Missense_Mutation_p.S513R|ZFHX4_ENST00000518282.1_Missense_Mutation_p.S513R|ZFHX4_ENST00000517683.1_Intron|ZFHX4_ENST00000050961.6_Missense_Mutation_p.S513R	NM_024721.4	NP_078997.4	Q86UP3	ZFHX4_HUMAN	zinc finger homeobox 4	513						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(3)|breast(11)|central_nervous_system(1)|endometrium(36)|haematopoietic_and_lymphoid_tissue(2)|kidney(15)|large_intestine(66)|liver(2)|lung(245)|ovary(11)|pancreas(3)|prostate(11)|skin(7)|upper_aerodigestive_tract(13)|urinary_tract(6)	432			BRCA - Breast invasive adenocarcinoma(89;0.0895)			TATCATCCAGTGTGCTAAAAT	0.418000										HNSCC(33;0.089)			5	44					0	0	0.014758	0	0
NCAN	1463	broad.mit.edu	37	19	19338661	19338661	+	Silent	SNP	C	C	A			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr19:19338661C>A	ENST00000252575.5	+	8	2275	c.2232C>A	c.(2230-2232)gcC>gcA	p.A744A	NCAN_ENST00000538881.1_Silent_p.A195A	NM_004386.2	NP_004377.2	O14594	NCAN_HUMAN	neurocan	744					axon guidance|cell adhesion	extracellular region	calcium ion binding|hyaluronic acid binding|sugar binding			breast(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(32)|ovary(5)|pancreas(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	64			Epithelial(12;0.00544)			CTGAGACTGCCACTGAGCCAA	0.587000													5	40					0.00198382	0.00247344	0.029380	1	0
DHX35	60625	broad.mit.edu	37	20	37617507	37617507	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr20:37617507G>T	ENST00000252011.3	+	5	430	c.397G>T	c.(397-399)Ggc>Tgc	p.G133C	DHX35_ENST00000373323.4_Missense_Mutation_p.G102C|DHX35_ENST00000373325.2_Missense_Mutation_p.G133C	NM_021931.3	NP_068750.2	Q9H5Z1	DHX35_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 35	133	Helicase ATP-binding.					catalytic step 2 spliceosome	ATP binding|ATP-dependent helicase activity|nucleic acid binding			breast(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(6)|lung(13)|ovary(1)|skin(2)|stomach(1)|urinary_tract(2)	40		Myeloproliferative disorder(115;0.00878)				CCACGAGGTGGGCTACTGCAT	0.483000													10	73					0.000673444	0.000884839	0.069234	1	0
CCDC114	93233	broad.mit.edu	37	19	48801477	48801477	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr19:48801477C>A	ENST00000315396.7	-	11	1932	c.1250G>T	c.(1249-1251)cGg>cTg	p.R417L		NM_144577.3	NP_653178.3	Q96M63	CC114_HUMAN	coiled-coil domain containing 114	417										cervix(2)|endometrium(3)|kidney(1)|large_intestine(5)|lung(5)|ovary(1)|pancreas(1)|prostate(3)|skin(2)|stomach(1)	24		all_epithelial(76;9.64e-05)|all_lung(116;0.000147)|Lung NSC(112;0.000251)|Prostate(7;0.0187)|all_neural(266;0.0228)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000134)|all cancers(93;0.000162)|Epithelial(262;0.0134)|GBM - Glioblastoma multiforme(486;0.0143)		CTCCACCAGCCGCTTCTCAAT	0.642000													3	20					0.004672	0.0056566	0.115264	1	0
CDH23	64072	broad.mit.edu	37	10	73569700	73569700	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr10:73569700A>G	ENST00000224721.6	+	60	8866	c.8861A>G	c.(8860-8862)tAc>tGc	p.Y2954C	CDH23_ENST00000398788.3_Missense_Mutation_p.Y709C|CDH23_ENST00000475158.1_3'UTR	NM_022124.5	NP_071407.4	Q9H251	CAD23_HUMAN	cadherin-related 23	2949	Cadherin 27.		D -> N.		calcium ion transport|calcium-dependent cell-cell adhesion|cytosolic calcium ion homeostasis|equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	cytosol|integral to membrane|plasma membrane|stereocilium	calcium ion binding|protein binding			NS(1)|breast(2)|central_nervous_system(6)|endometrium(15)|haematopoietic_and_lymphoid_tissue(5)|kidney(7)|large_intestine(27)|lung(49)|ovary(3)|pancreas(1)|prostate(7)|stomach(7)|upper_aerodigestive_tract(3)	133						ATCGGCATCTACATCCTGAGG	0.597000													7	56					0	0	0.047766	0	0
OIT3	170392	broad.mit.edu	37	10	74658669	74658669	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr10:74658669G>T	ENST00000334011.5	+	2	527	c.309G>T	c.(307-309)caG>caT	p.Q103H		NM_152635.1	NP_689848.1	Q8WWZ8	OIT3_HUMAN	oncoprotein induced transcript 3	103						nuclear envelope	calcium ion binding			autonomic_ganglia(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(9)|liver(2)|lung(14)|ovary(2)|prostate(1)|skin(2)	35	Prostate(51;0.0198)					TGCAACGCCAGGCTTGTGCCA	0.567000													4	28					0.00909568	0.0106177	0.009096	1	0
SLC11A1	6556	broad.mit.edu	37	2	219251378	219251378	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr2:219251378G>T	ENST00000233202.6	+	5	754	c.414G>T	c.(412-414)tgG>tgT	p.W138C	SLC11A1_ENST00000473367.1_3'UTR|SLC11A1_ENST00000539932.1_Missense_Mutation_p.W20C	NM_000578.3	NP_000569.3	P49279	NRAM1_HUMAN	solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1	138					activation of protein kinase activity|antigen processing and presentation of peptide antigen|cadmium ion transmembrane transport|cellular cadmium ion homeostasis|cellular iron ion homeostasis|defense response to Gram-negative bacterium|defense response to protozoan|divalent metal ion export|inflammatory response|interleukin-2 production|interleukin-3 production|iron ion transport|L-arginine import|macrophage activation|MHC class II biosynthetic process|mRNA stabilization|multicellular organismal iron ion homeostasis|negative regulation of cytokine production|nitrite transport|phagocytosis|positive regulation of dendritic cell antigen processing and presentation|positive regulation of interferon-gamma production|positive regulation of phagocytosis|positive regulation of T-helper 1 type immune response|positive regulation of transcription from RNA polymerase II promoter|respiratory burst|response to interferon-gamma|response to lipopolysaccharide|T cell cytokine production|T cell proliferation involved in immune response|vacuolar acidification|wound healing	integral to plasma membrane|late endosome membrane|lysosome|phagocytic vesicle membrane|tertiary granule membrane	manganese ion transmembrane transporter activity|metal ion:hydrogen antiporter activity|protein homodimerization activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(3)|ovary(3)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	19		Renal(207;0.0474)		Epithelial(149;1.16e-06)|all cancers(144;0.000195)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		CCGTCCTCTGGCTGACCATCG	0.567000													3	13					0.115264	0.125548	0.115264	1	0
TEP1	7011	broad.mit.edu	37	14	20837598	20837598	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr14:20837598G>C	ENST00000262715.5	-	53	7601	c.7561C>G	c.(7561-7563)Cca>Gca	p.P2521A	TEP1_ENST00000556935.1_Missense_Mutation_p.P2413A	NM_007110.4	NP_009041.2	Q99973	TEP1_HUMAN	telomerase-associated protein 1	2521					telomere maintenance via recombination	chromosome, telomeric region|cytoplasm|nuclear matrix|soluble fraction|telomerase holoenzyme complex	ATP binding|RNA binding			NS(4)|breast(1)|central_nervous_system(4)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(48)|ovary(7)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	96	all_cancers(95;0.00123)	all_lung(585;0.235)	Epithelial(56;7.42e-08)|all cancers(55;6.46e-07)	GBM - Glioblastoma multiforme(265;0.028)|READ - Rectum adenocarcinoma(17;0.233)		CAGGTAGATGGGTCTGTCCCT	0.507000													10	54					0	0	0.069234	0	0
CTNND2	1501	broad.mit.edu	37	5	11098731	11098731	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr5:11098731C>A	ENST00000304623.8	-	15	2782	c.2593G>T	c.(2593-2595)Ggg>Tgg	p.G865W	CTNND2_ENST00000495388.2_5'UTR|CTNND2_ENST00000511377.1_Missense_Mutation_p.G774W|CTNND2_ENST00000359640.2_Intron|CTNND2_ENST00000458100.2_Missense_Mutation_p.G432W|CTNND2_ENST00000503622.1_Missense_Mutation_p.G528W	NM_001332.2	NP_001323.1	Q9UQB3	CTND2_HUMAN	catenin (cadherin-associated protein), delta 2	865					multicellular organismal development|neuron cell-cell adhesion|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	adherens junction|cytoplasm|nucleus	protein binding			NS(1)|autonomic_ganglia(1)|breast(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(29)|liver(1)|lung(71)|ovary(4)|pancreas(2)|prostate(1)|skin(5)|upper_aerodigestive_tract(4)|urinary_tract(2)	136						CCTGCCGCCCCTTCCAGCGTG	0.517000													4	38					0.0293803	0.0327317	0.029380	1	0
HELZ	9931	broad.mit.edu	37	17	65214798	65214798	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr17:65214798C>A	ENST00000358691.5	-	4	289	c.123G>T	c.(121-123)atG>atT	p.M41I	HELZ_ENST00000580662.1_5'UTR|HELZ_ENST00000580168.1_Missense_Mutation_p.M41I	NM_014877.3	NP_055692.2			helicase with zinc finger											NS(1)|breast(5)|endometrium(9)|kidney(3)|large_intestine(11)|liver(1)|lung(24)|ovary(1)|pancreas(1)|prostate(1)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(2)	69	all_cancers(12;1.24e-11)|Breast(2;1.05e-17)|all_epithelial(3;3.87e-13)					TGAAGTCTGCCATGGAGTACT	0.458000													7	65					2.0095e-06	3.13182e-06	0.029380	1	0
LRRC7	57554	broad.mit.edu	37	1	70494020	70494020	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr1:70494020A>T	ENST00000310961.5	+	19	2280	c.1862A>T	c.(1861-1863)aAg>aTg	p.K621M	RP11-181B18.1_ENST00000414132.1_RNA|LRRC7_ENST00000035383.5_Missense_Mutation_p.K616M|LRRC7_ENST00000415775.2_Intron			Q96NW7	LRRC7_HUMAN	leucine rich repeat containing 7	616						centrosome|focal adhesion|nucleolus	protein binding			breast(11)|central_nervous_system(3)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(25)|liver(3)|lung(81)|ovary(9)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	162						TATGAACACAAGTGGCCGGTA	0.393000													4	44					0	0	0.021553	0	0
BTN3A2	11118	broad.mit.edu	37	6	26370770	26370770	+	Silent	SNP	A	A	T			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr6:26370770A>T	ENST00000356386.2	+	5	842	c.654A>T	c.(652-654)gtA>gtT	p.V218V	BTN3A2_ENST00000527422.1_Silent_p.V218V|BTN3A2_ENST00000508906.2_Silent_p.V176V|BTN3A2_ENST00000532994.1_3'UTR|BTN3A2_ENST00000396934.3_Silent_p.V195V|BTN3A2_ENST00000396948.1_Silent_p.V218V|BTN3A2_ENST00000377708.2_Silent_p.V218V	NM_001197246.2|NM_001197247.1|NM_007047.3	NP_001184175.1|NP_001184176.1|NP_008978.2	P78410	BT3A2_HUMAN	butyrophilin, subfamily 3, member A2	218						integral to membrane				central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(5)	10						GGGAGGGTGTATCCTGCATCA	0.542000													10	113					0	0	0.069234	0	0
SHISA9	729993	broad.mit.edu	37	16	13297311	13297311	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr16:13297311C>T	ENST00000558583.1	+	3	1197	c.875C>T	c.(874-876)cCa>cTa	p.P292L	SHISA9_ENST00000424107.3_Missense_Mutation_p.P251L|AC009134.1_ENST00000571939.1_RNA	NM_001145204.2	NP_001138676.2	B4DS77	SHSA9_HUMAN	shisa family member 9	251					regulation of short-term neuronal synaptic plasticity	cell junction|dendritic spine membrane|ionotropic glutamate receptor complex|synapse				breast(1)|endometrium(2)|kidney(1)|lung(2)|prostate(1)|skin(2)	9						ATGGGCCATCCACATTCGTAC	0.547000													3	13					0	0	0.009096	0	0
DNAH10	196385	broad.mit.edu	37	12	124382375	124382375	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr12:124382375G>T	ENST00000409039.3	+	54	9010	c.8985G>T	c.(8983-8985)ttG>ttT	p.L2995F		NM_207437.3	NP_997320.2	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	2995	AAA 4 (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(14)|ovary(4)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	52	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		ATGTTGTCTTGGTTCACCAAT	0.388000													4	82					0.000602214	0.000794815	0.014758	1	0
MTOR	2475	broad.mit.edu	37	1	11175493	11175493	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr1:11175493C>A	ENST00000361445.4	-	51	7125	c.7049G>T	c.(7048-7050)aGt>aTt	p.S2350I	MTOR_ENST00000376838.1_Missense_Mutation_p.S555I	NM_004958.3	NP_004949.1	P42345	MTOR_HUMAN	mechanistic target of rapamycin (serine/threonine kinase)	2350	PI3K/PI4K.				cell growth|cellular response to hypoxia|insulin receptor signaling pathway|nerve growth factor receptor signaling pathway|peptidyl-serine phosphorylation|phosphatidylinositol-mediated signaling|protein autophosphorylation|protein catabolic process|response to amino acid stimulus|response to nutrient|T cell costimulation|TOR signaling cascade	endoplasmic reticulum membrane|Golgi membrane|lysosome|mitochondrial outer membrane|phosphatidylinositol 3-kinase complex|PML body|TORC1 complex|TORC2 complex	ATP binding|phosphoprotein binding|protein serine/threonine kinase activity			breast(5)|central_nervous_system(7)|endometrium(20)|kidney(34)|large_intestine(21)|lung(43)|ovary(9)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	149						GATCTTCCCACTCAGACGGTC	0.478000													6	115					0.00198382	0.00247344	0.029380	1	0
ACAP2	23527	broad.mit.edu	37	3	195063241	195063241	+	Nonsense_Mutation	SNP	T	T	A			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr3:195063241T>A	ENST00000326793.6	-	6	717	c.487A>T	c.(487-489)Aga>Tga	p.R163*		NM_012287.5	NP_036419.3	Q15057	ACAP2_HUMAN	ArfGAP with coiled-coil, ankyrin repeat and PH domains 2	163	BAR.				regulation of ARF GTPase activity		ARF GTPase activator activity|zinc ion binding			cervix(2)|endometrium(2)|kidney(4)|large_intestine(5)|lung(10)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(2)	27						AAACATTTTCTTGTTGCTGTC	0.363000													7	62					0	0	0.029380	0	0
FAP	2191	broad.mit.edu	37	2	163075644	163075644	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr2:163075644G>T	ENST00000188790.4	-	8	743	c.536C>A	c.(535-537)cCa>cAa	p.P179Q	FAP_ENST00000443424.1_Missense_Mutation_p.P154Q	NM_004460.2	NP_004451.2	Q12884	SEPR_HUMAN	fibroblast activation protein, alpha	179					endothelial cell migration|negative regulation of extracellular matrix disassembly|proteolysis	cell junction|integral to membrane|invadopodium membrane|lamellipodium membrane	dipeptidyl-peptidase activity|metalloendopeptidase activity|protein homodimerization activity|serine-type endopeptidase activity			NS(2)|breast(1)|central_nervous_system(2)|endometrium(5)|kidney(1)|large_intestine(5)|lung(34)|ovary(4)|prostate(3)|skin(2)|upper_aerodigestive_tract(4)	63						TTGAAAAGGTGGATCTCCTGG	0.328000													5	89					0.0293803	0.0327317	0.029380	1	0
GTF2IRD2P1	401375	broad.mit.edu	37	7	72657818	72657818	+	RNA	SNP	G	G	T			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr7:72657818G>T	ENST00000425256.1	-	0	2093					NR_002164.1																						atacatctgcgtgacgatttg	0.498000													11	109					1.05317e-09	1.81517e-09	0.119110	1	0
GRHL3	57822	broad.mit.edu	37	1	24663023	24663023	+	Silent	SNP	C	C	G			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr1:24663023C>G	ENST00000361548.4	+	4	548	c.318C>G	c.(316-318)ccC>ccG	p.P106P	GRHL3_ENST00000356046.2_Silent_p.P60P|GRHL3_ENST00000350501.5_Silent_p.P106P|GRHL3_ENST00000236255.4_Silent_p.P111P|GRHL3_ENST00000530984.1_3'UTR|GRHL3_ENST00000342072.4_Silent_p.P13P	NM_198173.2	NP_937816.1	Q8TE85	GRHL3_HUMAN	grainyhead-like 3 (Drosophila)	106					regulation of actin cytoskeleton organization|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)|pancreas(3)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	20		Colorectal(325;3.46e-05)|Renal(390;0.0007)|Lung NSC(340;0.00171)|all_lung(284;0.00226)|Ovarian(437;0.00348)|Breast(348;0.0126)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.19)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;8.72e-25)|Colorectal(126;4.38e-08)|COAD - Colon adenocarcinoma(152;1.84e-06)|GBM - Glioblastoma multiforme(114;0.000132)|BRCA - Breast invasive adenocarcinoma(304;0.00105)|STAD - Stomach adenocarcinoma(196;0.00151)|KIRC - Kidney renal clear cell carcinoma(1967;0.00377)|READ - Rectum adenocarcinoma(331;0.0656)|Lung(427;0.143)		TTGAAAGCCCCACACACCTCA	0.517000													4	75					0	0	0.014758	0	0
OR7C1	26664	broad.mit.edu	37	19	14910178	14910178	+	Silent	SNP	C	C	A			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr19:14910178C>A	ENST00000248073.2	-	1	845	c.771G>T	c.(769-771)ggG>ggT	p.G257G	OR7A5_ENST00000601611.1_Intron	NM_198944.1	NP_945182.1	O76099	OR7C1_HUMAN	olfactory receptor, family 7, subfamily C, member 1	257					sensory perception of smell|spermatogenesis	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|central_nervous_system(1)|endometrium(2)|large_intestine(8)|lung(2)|ovary(2)|prostate(1)	18						TGAGATAGACCCCAAAGCCCG	0.522000													7	66					2.0095e-06	3.13182e-06	0.029380	1	0
THAP2	83591	broad.mit.edu	37	12	72068146	72068146	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr12:72068146A>G	ENST00000308086.2	+	2	1736	c.235A>G	c.(235-237)Att>Gtt	p.I79V	RP11-293I14.2_ENST00000548802.1_Missense_Mutation_p.I55V	NM_031435.3	NP_113623.1	Q9H0W7	THAP2_HUMAN	THAP domain containing, apoptosis associated protein 2	79						nucleolus	DNA binding|metal ion binding			endometrium(1)|kidney(1)|large_intestine(3)|lung(3)|ovary(1)|skin(1)	10						TGTTCCAACCATTTTTGATTT	0.353000													5	31					0	0	0.021553	0	0
PCK1	5105	broad.mit.edu	37	20	56140518	56140518	+	Silent	SNP	C	C	A			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr20:56140518C>A	ENST00000319441.4	+	10	1691	c.1527C>A	c.(1525-1527)ccC>ccA	p.P509P	PCK1_ENST00000535860.1_3'UTR|PCK1_ENST00000543666.1_Silent_p.P192P	NM_002591.3	NP_002582.3	P35558	PCKGC_HUMAN	phosphoenolpyruvate carboxykinase 1 (soluble)	509					gluconeogenesis|glucose homeostasis|glycerol biosynthetic process from pyruvate|response to insulin stimulus	cytosol|nucleus	carboxylic acid binding|GTP binding|magnesium ion binding|manganese ion binding|phosphoenolpyruvate carboxykinase (GTP) activity			endometrium(2)|kidney(1)|large_intestine(4)|liver(2)|lung(19)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	34	Lung NSC(12;0.000764)|all_lung(29;0.00264)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(13;9.88e-12)|Epithelial(14;3.41e-08)|all cancers(14;2.13e-07)			CCAAACTGCCCAAGATCTTCC	0.557000													4	41					0.00024832	0.000335289	0.009096	1	0
CDH8	1006	broad.mit.edu	37	16	61760956	61760956	+	Nonsense_Mutation	SNP	G	G	T			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr16:61760956G>T	ENST00000584337.1	-	9	2099	c.1578C>A	c.(1576-1578)taC>taA	p.Y526*	CDH8_ENST00000577390.1_Intron|CDH8_ENST00000299345.6_Intron|CDH8_ENST00000577730.1_Intron			P55286	CADH8_HUMAN	cadherin 8, type 2	636	Cadherin 5.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			biliary_tract(1)|breast(3)|cervix(1)|endometrium(7)|kidney(6)|large_intestine(22)|liver(2)|lung(49)|ovary(6)|pancreas(2)|prostate(5)|skin(4)|urinary_tract(4)	112		Ovarian(137;0.0799)|Melanoma(118;0.16)		UCEC - Uterine corpus endometrioid carcinoma (183;0.196)|Epithelial(162;0.0155)|all cancers(182;0.0305)|OV - Ovarian serous cystadenocarcinoma(108;0.0499)|BRCA - Breast invasive adenocarcinoma(181;0.249)		TGAGACAGTTGTATACAAACA	0.373000													8	86					1.12685e-05	1.70189e-05	0.047766	1	0
DDX25	29118	broad.mit.edu	37	11	125778309	125778309	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr11:125778309A>G	ENST00000263576.6	+	6	573	c.418A>G	c.(418-420)Ata>Gta	p.I140V	DDX25_ENST00000525943.1_3'UTR|RP11-680F20.9_ENST00000533033.2_RNA	NM_013264.4	NP_037396.3	Q9UHL0	DDX25_HUMAN	DEAD (Asp-Glu-Ala-Asp) box helicase 25	140	Helicase ATP-binding.				mRNA export from nucleus|multicellular organismal development|regulation of translation|spermatid development	chromatoid body|nucleus	ATP binding|ATP-dependent RNA helicase activity|RNA binding			breast(2)|endometrium(2)|kidney(1)|large_intestine(2)|ovary(2)|upper_aerodigestive_tract(1)	10	all_hematologic(175;0.177)	Breast(109;0.0021)|all_lung(97;0.0203)|Lung NSC(97;0.0203)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.14e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.046)		CCAGAACCTCATAGCACAGAG	0.433000													6	346					0	0	0.038147	0	0
ITGAM	3684	broad.mit.edu	37	16	31309111	31309111	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr16:31309111C>A	ENST00000544665.3	+	14	1617	c.1546C>A	c.(1546-1548)Caa>Aaa	p.Q516K	ITGAM_ENST00000287497.8_Missense_Mutation_p.Q515K	NM_000632.3|NM_001145808.1	NP_000623.2|NP_001139280.1	P11215	ITAM_HUMAN	integrin, alpha M (complement component 3 receptor 3 subunit)	515					blood coagulation|cell adhesion|integrin-mediated signaling pathway|leukocyte migration	integrin complex	glycoprotein binding|receptor activity			endometrium(7)|kidney(1)|large_intestine(10)|lung(32)|ovary(1)|prostate(4)|skin(1)	56						GGAGCAGGGCCAACCCTGGGG	0.632000													7	117					0.000157383	0.000218546	0.038147	1	0
NOTCH2	4853	broad.mit.edu	37	1	120458384	120458384	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr1:120458384C>A	ENST00000256646.2	-	34	7180	c.6961G>T	c.(6961-6963)Gct>Tct	p.A2321S		NM_024408.3	NP_077719.2	Q04721	NOTC2_HUMAN	notch 2	2321					anti-apoptosis|bone remodeling|cell cycle arrest|cell fate determination|cell growth|hemopoiesis|induction of apoptosis|negative regulation of cell proliferation|nervous system development|Notch receptor processing|Notch signaling pathway|organ morphogenesis|positive regulation of Ras protein signal transduction|regulation of transcription, DNA-dependent|stem cell maintenance|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|ligand-regulated transcription factor activity|protein binding|receptor activity			breast(4)|central_nervous_system(6)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(9)|kidney(9)|large_intestine(19)|liver(1)|lung(57)|ovary(4)|pancreas(1)|prostate(7)|skin(24)|stomach(2)|upper_aerodigestive_tract(5)|urinary_tract(1)	158	all_neural(166;0.153)	all_lung(203;1.96e-06)|Lung NSC(69;1.47e-05)|all_epithelial(167;0.000809)		Lung(183;0.0242)|LUSC - Lung squamous cell carcinoma(189;0.133)		GGCTGGGGAGCCCCCGCTGGT	0.622000			"""N, F, Mis"""		"""marginal zone lymphoma, DLBCL"""				Alagille Syndrome				5	57					0.0215528	0.0244766	0.021553	1	0
LRRC66	339977	broad.mit.edu	37	4	52861612	52861612	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr4:52861612C>A	ENST00000343457.3	-	4	1582	c.1576G>T	c.(1576-1578)Gac>Tac	p.D526Y		NM_001024611.1	NP_001019782.1	Q68CR7	LRC66_HUMAN	leucine rich repeat containing 66	526						integral to membrane				central_nervous_system(1)|endometrium(9)|kidney(1)|large_intestine(8)|lung(34)|ovary(1)|pancreas(1)|prostate(2)|skin(1)	58						TGGATGTGGTCCTGCGCTGCT	0.512000													12	128					7.03913e-09	1.17185e-08	0.093190	1	0
NOTCH4	4855	broad.mit.edu	37	6	32184944	32184944	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr6:32184944C>A	ENST00000375023.3	-	10	1862	c.1724G>T	c.(1723-1725)tGc>tTc	p.C575F		NM_004557.3	NP_004548.3	Q99466	NOTC4_HUMAN	notch 4	575	EGF-like 14; calcium-binding (Potential).				cell fate determination|embryo development|hemopoiesis|mammary gland development|negative regulation of endothelial cell differentiation|Notch receptor processing|Notch signaling pathway|patterning of blood vessels|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|protein heterodimerization activity|receptor activity			NS(1)|autonomic_ganglia(1)|breast(4)|central_nervous_system(4)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(47)|ovary(5)|prostate(4)|skin(10)|upper_aerodigestive_tract(1)|urinary_tract(1)	100						GAGACACTTGCAGTGGAAGGC	0.617000													5	32					0.0293803	0.0327317	0.029380	1	0
VWCE	220001	broad.mit.edu	37	11	61026770	61026770	+	Silent	SNP	G	G	A			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr11:61026770G>A	ENST00000335613.5	-	20	2631	c.2245C>T	c.(2245-2247)Ctg>Ttg	p.L749L	VWCE_ENST00000535710.1_Silent_p.L214L	NM_152718.2	NP_689931.2	Q96DN2	VWCE_HUMAN	von Willebrand factor C and EGF domains	749						extracellular region	calcium ion binding			biliary_tract(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(17)|ovary(3)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	37						TTTTCTTCCAGAGGAGACAGG	0.567000													7	37					0	0	0.047766	0	0
ARR3	407	broad.mit.edu	37	X	69500067	69500067	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chrX:69500067G>C	ENST00000374495.3	+	13	1026	c.928G>C	c.(928-930)Gag>Cag	p.E310Q	ARR3_ENST00000307959.8_Missense_Mutation_p.E310Q			P36575	ARRC_HUMAN	arrestin 3, retinal (X-arrestin)	310					signal transduction|visual perception	cytoplasm|soluble fraction				endometrium(3)|kidney(1)|large_intestine(4)|lung(4)|ovary(2)|prostate(1)|skin(1)	16						AATGGACAAAGAGCTGCTGGG	0.502000													13	175					0	0	0.119110	0	0
PDE4A	5141	broad.mit.edu	37	19	10571737	10571737	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr19:10571737G>T	ENST00000380702.2	+	12	1357	c.1357G>T	c.(1357-1359)Gtg>Ttg	p.V453L	PDE4A_ENST00000293683.5_Missense_Mutation_p.V449L|PDE4A_ENST00000352831.6_Missense_Mutation_p.V475L|PDE4A_ENST00000592685.1_Missense_Mutation_p.V453L|PDE4A_ENST00000440014.2_Missense_Mutation_p.V414L|PDE4A_ENST00000344979.3_Missense_Mutation_p.V236L			P27815	PDE4A_HUMAN	phosphodiesterase 4A, cAMP-specific	475	Catalytic.				signal transduction	cytosol|membrane fraction|perinuclear region of cytoplasm|ruffle membrane|soluble fraction	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding|protein binding			NS(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(4)|large_intestine(3)|lung(4)|ovary(2)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	27			OV - Ovarian serous cystadenocarcinoma(20;5.8e-10)|Epithelial(33;7.58e-07)|all cancers(31;3.91e-06)		Cilostazol(DB01166)|Dipyridamole(DB00975)|Dyphylline(DB00651)|Enprofylline(DB00824)|Iloprost(DB01088)|Milrinone(DB00235)|Pentoxifylline(DB00806)|Phentolamine(DB00692)|Tadalafil(DB00820)|Theophylline(DB00277)	CATCCACGATGTGGATCACCC	0.602000													3	35					0.00024832	0.000335289	0.009096	1	0
UGT2B4	7363	broad.mit.edu	37	4	70361152	70361152	+	Nonsense_Mutation	SNP	G	G	T			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr4:70361152G>T	ENST00000305107.6	-	1	474	c.428C>A	c.(427-429)tCa>tAa	p.S143*	UGT2B4_ENST00000512583.1_Nonsense_Mutation_p.S143*|UGT2B4_ENST00000506580.1_5'UTR|UGT2B4_ENST00000381096.3_Intron	NM_021139.2	NP_066962.2	P06133	UD2B4_HUMAN	UDP glucuronosyltransferase 2 family, polypeptide B4	143					estrogen catabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(29)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	47						ATCAAATCTTGACTCCTGTAG	0.383000													5	29					2.7689e-08	4.53233e-08	0.029380	1	0
GC	2638	broad.mit.edu	37	4	72631341	72631341	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr4:72631341T>A	ENST00000273951.8	-	4	624	c.281A>T	c.(280-282)aAg>aTg	p.K94M	GC_ENST00000504199.1_Missense_Mutation_p.K113M|GC_ENST00000513476.1_Missense_Mutation_p.K94M|GC_ENST00000503472.1_Intron	NM_000583.3|NM_001204306.1	NP_000574.2|NP_001191235.1	P02774	VTDB_HUMAN	group-specific component (vitamin D binding protein)	94	Albumin 1.				hormone biosynthetic process|vitamin D metabolic process	cytosol|lysosomal lumen	actin binding|vitamin D binding|vitamin transporter activity			endometrium(5)|kidney(1)|large_intestine(4)|lung(21)|ovary(2)|pancreas(1)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(4)	45		all_hematologic(202;0.107)	Lung(101;0.148)		Cholecalciferol(DB00169)	TTCACAGGACTTGGCAGACAG	0.443000													6	67					0	0	0.021553	0	0
ITGA4	3676	broad.mit.edu	37	2	182339745	182339745	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr2:182339745G>T	ENST00000397033.2	+	3	808	c.378G>T	c.(376-378)tgG>tgT	p.W126C	ITGA4_ENST00000478440.1_3'UTR|ITGA4_ENST00000339307.4_Missense_Mutation_p.W126C	NM_000885.4	NP_000876.3	P13612	ITA4_HUMAN	integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)	126					blood coagulation|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|regulation of immune response	integrin complex	identical protein binding|receptor activity			breast(3)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(9)|lung(27)|ovary(3)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	58			OV - Ovarian serous cystadenocarcinoma(117;0.0593)		Natalizumab(DB00108)	ACAATCAGTGGTTGGGGGTCA	0.433000													4	55					0.00116845	0.00148205	0.021553	1	0
EML1	2009	broad.mit.edu	37	14	100380643	100380643	+	Splice_Site	SNP	T	T	C			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr14:100380643T>C	ENST00000262233.6	+	14	1759		c.e14+2		EML1_ENST00000334192.4_Splice_Site|EML1_ENST00000327921.9_Splice_Site	NM_004434.2	NP_004425.2	O00423	EMAL1_HUMAN	echinoderm microtubule associated protein like 1							cytoplasm|microtubule|microtubule associated complex	calcium ion binding|protein binding			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(15)|lung(9)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	42		Melanoma(154;0.0879)|all_epithelial(191;0.216)				ATTACTCAGGTACGATCCCAC	0.488000													5	71					0	0	0.021553	0	0
KMT2C	58508	broad.mit.edu	37	7	151860827	151860827	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr7:151860827T>C	ENST00000355193.2	-	43	10053	c.9835A>G	c.(9835-9837)Acc>Gcc	p.T3279A	KMT2C_ENST00000262189.6_Missense_Mutation_p.T3279A					lysine (K)-specific methyltransferase 2C																		GGCATCATGGTAGGTGGGGCC	0.502000													3	72					0	0	0.009096	0	0
RAP2C	57826	broad.mit.edu	37	X	131351168	131351168	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chrX:131351168C>A	ENST00000342983.2	-	2	875	c.129G>T	c.(127-129)gaG>gaT	p.E43D	RAP2C_ENST00000370874.1_Missense_Mutation_p.E43D|RAP2C_ENST00000460462.1_5'UTR	NM_001271186.1|NM_001271187.1|NM_021183.3	NP_001258115.1|NP_001258116.1|NP_067006.3	Q9Y3L5	RAP2C_HUMAN	RAP2C, member of RAS oncogene family	43					negative regulation of cell migration|positive regulation of protein autophosphorylation|Rap protein signal transduction|regulation of protein tyrosine kinase activity	recycling endosome membrane	GTP binding|GTPase activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|lung(1)|ovary(1)|upper_aerodigestive_tract(2)	8	Acute lymphoblastic leukemia(192;0.000127)					CCACTTCGATCTCTTTGCGGT	0.498000													7	111					2.0095e-06	3.13182e-06	0.029380	1	0
DPP4	1803	broad.mit.edu	37	2	162894882	162894882	+	Silent	SNP	T	T	A			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr2:162894882T>A	ENST00000360534.3	-	8	1103	c.543A>T	c.(541-543)ccA>ccT	p.P181P		NM_001935.3	NP_001926.2	P27487	DPP4_HUMAN	dipeptidyl-peptidase 4	181					cell adhesion|endothelial cell migration|negative regulation of extracellular matrix disassembly|positive regulation of cell proliferation|proteolysis|regulation of cell-cell adhesion mediated by integrin|response to hypoxia|T cell activation|T cell costimulation	apical plasma membrane|cell surface|endocytic vesicle|extracellular region|integral to membrane|invadopodium membrane|lamellipodium membrane|membrane raft	aminopeptidase activity|dipeptidyl-peptidase activity|protease binding|protein homodimerization activity|receptor activity|receptor binding|serine-type endopeptidase activity			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|liver(1)|lung(21)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	48					Sitagliptin(DB01261)	TTCTGTAACTTGGTAAATTTG	0.289000													3	30					0	0	0.115264	0	0
CRMP1	1400	broad.mit.edu	37	4	5862927	5862927	+	Nonsense_Mutation	SNP	C	C	A			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr4:5862927C>A	ENST00000324989.7	-	3	569	c.481G>T	c.(481-483)Gag>Tag	p.E161*	CRMP1_ENST00000511535.1_5'UTR|CRMP1_ENST00000512574.1_Nonsense_Mutation_p.E45*|CRMP1_ENST00000397890.2_Nonsense_Mutation_p.E47*	NM_001014809.1	NP_001014809.1	Q14194	DPYL1_HUMAN	collapsin response mediator protein 1	47					axon guidance|pyrimidine base catabolic process	cytosol|microtubule organizing center|spindle	dihydropyrimidinase activity|protein binding			NS(1)|cervix(2)|endometrium(4)|large_intestine(10)|lung(11)|ovary(2)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	36				Colorectal(103;0.0721)		ATTAAGTTCTCTCCTATTTGT	0.473000													10	75					9.70103e-10	1.69191e-09	0.069234	1	0
YEATS2	55689	broad.mit.edu	37	3	183446631	183446631	+	Silent	SNP	G	G	T			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr3:183446631G>T	ENST00000305135.5	+	7	999	c.804G>T	c.(802-804)gtG>gtT	p.V268V		NM_018023.4	NP_060493.3	Q9ULM3	YETS2_HUMAN	YEATS domain containing 2	268	YEATS.				histone H3 acetylation|negative regulation of transcription from RNA polymerase II promoter	Ada2/Gcn5/Ada3 transcription activator complex	TBP-class protein binding			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(24)|ovary(3)|prostate(2)|skin(3)	49	all_cancers(143;6.55e-10)|Ovarian(172;0.0303)		all cancers(12;2.38e-42)|Epithelial(37;1.9e-36)|OV - Ovarian serous cystadenocarcinoma(80;6.48e-22)			ATGACCTTGTGGAAGTTAGGT	0.378000													5	51					0.00116845	0.00148205	0.021553	1	0
DCK	1633	broad.mit.edu	37	4	71863875	71863875	+	Silent	SNP	T	T	A			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr4:71863875T>A	ENST00000286648.5	+	2	580	c.183T>A	c.(181-183)gtT>gtA	p.V61V	MOB1B_ENST00000511449.1_3'UTR|DCK_ENST00000504730.1_Silent_p.V61V|DCK_ENST00000504952.1_Silent_p.V61V	NM_000788.2	NP_000779.1	P27707	DCK_HUMAN	deoxycytidine kinase	61					purine base metabolic process|purine-containing compound salvage|pyrimidine base metabolic process|pyrimidine nucleoside salvage|pyrimidine nucleotide metabolic process	cytosol|nucleus	ATP binding|deoxycytidine kinase activity|drug binding|phosphotransferase activity, alcohol group as acceptor|protein homodimerization activity			endometrium(2)|large_intestine(3)|lung(3)|ovary(1)	9			Lung(101;0.235)		Cladribine(DB00242)|Clofarabine(DB00631)|Decitabine(DB01262)|Fludarabine(DB01073)|Gemcitabine(DB00441)|Pemetrexed(DB00642)|Zalcitabine(DB00943)	GGTGCAATGTTCAAAGTACTC	0.358000													5	56					0	0	0.021553	0	0
CNTNAP2	26047	broad.mit.edu	37	7	146818111	146818111	+	Silent	SNP	G	G	C			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr7:146818111G>C	ENST00000361727.3	+	6	1311	c.795G>C	c.(793-795)gtG>gtC	p.V265V		NM_014141.5	NP_054860.1	Q9UHC6	CNTP2_HUMAN	contactin associated protein-like 2	265	Laminin G-like 1.				behavior|cell adhesion|clustering of voltage-gated potassium channels|limbic system development|neuron recognition|signal transduction|striatum development|superior temporal gyrus development|thalamus development|transmission of nerve impulse	axolemma|cell body fiber|dendrite|juxtaparanode region of axon|voltage-gated potassium channel complex	receptor binding			NS(3)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(21)|lung(105)|ovary(9)|pancreas(2)|prostate(5)|skin(7)|stomach(3)|upper_aerodigestive_tract(6)|urinary_tract(3)	188	Melanoma(164;0.153)	all_cancers(3;3.51e-10)|all_epithelial(3;1.4e-05)|Myeloproliferative disorder(3;0.00452)|Lung NSC(3;0.0067)|all_lung(3;0.00794)	OV - Ovarian serous cystadenocarcinoma(82;0.0319)			ACACATCAGTGATGACAGGAA	0.517000										HNSCC(39;0.1)			7	67					0	0	0.047766	0	0
CNGA4	1262	broad.mit.edu	37	11	6265516	6265516	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr11:6265516G>T	ENST00000379936.2	+	6	1720	c.1605G>T	c.(1603-1605)caG>caT	p.Q535H		NM_001037329.3	NP_001032406.1	Q8IV77	CNGA4_HUMAN	cyclic nucleotide gated channel alpha 4	535					response to stimulus|sensory perception of smell		cAMP binding			endometrium(2)|kidney(1)|large_intestine(9)|lung(24)|prostate(3)|skin(1)	40		Medulloblastoma(188;0.00263)|all_neural(188;0.026)|Breast(177;0.029)		Epithelial(150;2.04e-08)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TGGAGTGGCAGACTCGAGAGT	0.587000													6	43					0.00116845	0.00148205	0.021553	1	0
AL033381.1	0	broad.mit.edu	37	6	1102098	1102098	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr6:1102098C>G	ENST00000314040.1	+	3	352	c.82C>G	c.(82-84)Ctc>Gtc	p.L28V																								CAGCTCTGCCCTCCCCACATC	0.428000													3	26					0	0	0.115264	0	0
OR1F2P	26184	broad.mit.edu	37	16	3266034	3266034	+	RNA	SNP	C	C	G			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr16:3266034C>G	ENST00000576468.1	+	0	418																											GCTCTGTGCCCTGCTGGTCAC	0.557000													3	42					0	0	0.009096	0	0
KCNQ5	56479	broad.mit.edu	37	6	73904438	73904438	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr6:73904438G>T	ENST00000342056.2	+	15	2555	c.2157G>T	c.(2155-2157)caG>caT	p.Q719H	KCNQ5_ENST00000402622.2_Missense_Mutation_p.Q710H|KCNQ5_ENST00000403813.2_Missense_Mutation_p.Q691H|KCNQ5_ENST00000370398.1_Missense_Mutation_p.Q700H|KCNQ5_ENST00000355635.3_Missense_Mutation_p.Q701H|KCNQ5_ENST00000355194.4_Missense_Mutation_p.Q700H|KCNQ5_ENST00000414165.2_Missense_Mutation_p.Q590H	NM_001160132.1|NM_001160133.1	NP_001153604.1|NP_001153605.1	Q9NR82	KCNQ5_HUMAN	potassium voltage-gated channel, KQT-like subfamily, member 5	700					protein complex assembly|synaptic transmission	voltage-gated potassium channel complex	inward rectifier potassium channel activity			breast(1)|cervix(1)|endometrium(6)|kidney(7)|large_intestine(13)|lung(15)|ovary(4)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	57		all_epithelial(107;0.116)|Lung NSC(302;0.219)		COAD - Colon adenocarcinoma(1;0.0107)|Colorectal(1;0.0583)		TCAGTGCCCAGACTTTCTACG	0.517000													18	131					8.34094e-07	1.33546e-06	0.049695	1	0
TRPS1	7227	broad.mit.edu	37	8	116632198	116632198	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr8:116632198C>G	ENST00000395715.3	-	3	704	c.127G>C	c.(127-129)Gta>Cta	p.V43L	TRPS1_ENST00000520276.1_Missense_Mutation_p.V34L|TRPS1_ENST00000519076.1_Missense_Mutation_p.V30L|TRPS1_ENST00000519674.1_Missense_Mutation_p.V30L|TRPS1_ENST00000220888.5_Missense_Mutation_p.V30L	NM_014112.2	NP_054831.2	Q9UHF7	TRPS1_HUMAN	trichorhinophalangeal syndrome I	30					negative regulation of transcription from RNA polymerase II promoter|NLS-bearing substrate import into nucleus|regulation of chondrocyte differentiation|skeletal system development|transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			autonomic_ganglia(1)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(25)|lung(58)|ovary(3)|pancreas(1)|prostate(1)|skin(6)|urinary_tract(2)	111	all_cancers(13;5.44e-23)|all_epithelial(1;2.14e-27)|Lung NSC(37;2.55e-05)|Ovarian(258;0.0219)		Epithelial(1;9.78e-37)|all cancers(1;3.14e-31)|BRCA - Breast invasive adenocarcinoma(1;2.56e-12)			TTTCCAGATACCTTGCTTTCT	0.443000									Langer-Giedion syndrome				5	50					0	0	0.029380	0	0
TP53	7157	broad.mit.edu	37	17	7578556	7578556	+	Splice_Site	SNP	T	T	A			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr17:7578556T>A	ENST00000420246.2	-	5	508		c.e5-2		TP53_ENST00000413465.2_Splice_Site|TP53_ENST00000359597.4_Splice_Site|TP53_ENST00000269305.4_Splice_Site|TP53_ENST00000445888.2_Splice_Site|TP53_ENST00000455263.2_Splice_Site	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53						activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.?(34)|p.0?(8)|p.V73fs*9(1)|p.Y126fs*11(1)|p.P13fs*18(1)|p.T125_Y126insX(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		AGGGGAGTACTGTAGGAAGAG	0.552000		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			3	43					0	0	0.115264	0	0
SLCO5A1	81796	broad.mit.edu	37	8	70585416	70585416	+	Silent	SNP	G	G	C			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr8:70585416G>C	ENST00000260126.3	-	10	2941	c.2235C>G	c.(2233-2235)ctC>ctG	p.L745L	SLCO5A1_ENST00000524945.1_3'UTR|SLCO5A1_ENST00000530307.1_Silent_p.L690L	NM_030958.2	NP_112220.2	Q9H2Y9	SO5A1_HUMAN	solute carrier organic anion transporter family, member 5A1	745						integral to membrane|plasma membrane	transporter activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(11)|lung(24)|ovary(3)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	53	Breast(64;0.0654)		Epithelial(68;0.0141)|OV - Ovarian serous cystadenocarcinoma(28;0.0315)|all cancers(69;0.0594)			CAACGAATTTGAGGCCGGCAG	0.488000													18	155					0	0	0.043863	0	0
ZNF682	91120	broad.mit.edu	37	19	20117104	20117104	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr19:20117104C>A	ENST00000397165.2	-	4	1367	c.1207G>T	c.(1207-1209)Ggc>Tgc	p.G403C	ZNF682_ENST00000597972.1_Missense_Mutation_p.G409C|ZNF682_ENST00000595736.1_Missense_Mutation_p.G327C|ZNF682_ENST00000397162.1_Missense_Mutation_p.G371C|ZNF682_ENST00000358523.5_Missense_Mutation_p.G371C|ZNF682_ENST00000596019.1_Intron	NM_033196.2	NP_149973.1	O95780	ZN682_HUMAN	zinc finger protein 682	403					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|large_intestine(2)|lung(6)|ovary(1)|pancreas(1)|prostate(1)|stomach(1)|urinary_tract(1)	14						AAAGCTTTGCCACATTCTTCA	0.373000													5	53					3.59834e-05	5.32481e-05	0.021553	1	0
PCK1	5105	broad.mit.edu	37	20	56138640	56138640	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr20:56138640C>A	ENST00000319441.4	+	6	982	c.818C>A	c.(817-819)cCt>cAt	p.P273H	PCK1_ENST00000535860.1_Missense_Mutation_p.P141H|PCK1_ENST00000543666.1_Intron	NM_002591.3	NP_002582.3	P35558	PCKGC_HUMAN	phosphoenolpyruvate carboxykinase 1 (soluble)	273					gluconeogenesis|glucose homeostasis|glycerol biosynthetic process from pyruvate|response to insulin stimulus	cytosol|nucleus	carboxylic acid binding|GTP binding|magnesium ion binding|manganese ion binding|phosphoenolpyruvate carboxykinase (GTP) activity			endometrium(2)|kidney(1)|large_intestine(4)|liver(2)|lung(19)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	34	Lung NSC(12;0.000764)|all_lung(29;0.00264)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(13;9.88e-12)|Epithelial(14;3.41e-08)|all cancers(14;2.13e-07)			ATAACCAACCCTGAGGGTGAG	0.542000													4	38					0.00909568	0.0106177	0.009096	1	0
APBB1IP	54518	broad.mit.edu	37	10	26790049	26790049	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr10:26790049G>C	ENST00000356785.4	+	5	695	c.462G>C	c.(460-462)atG>atC	p.M154I	APBB1IP_ENST00000376236.4_Intron			Q7Z5R6	AB1IP_HUMAN	amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein	0	Poly-Glu.				blood coagulation|signal transduction	cytoskeleton|cytosol|focal adhesion|lamellipodium				central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(27)|skin(7)|upper_aerodigestive_tract(1)	45						AGGTAAGTATGTGGGACCAGA	0.488000													12	134					0	0	0.119110	0	0
ADCY5	111	broad.mit.edu	37	3	123044228	123044228	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr3:123044228C>G	ENST00000462833.1	-	8	3241	c.2029G>C	c.(2029-2031)Gag>Cag	p.E677Q	ADCY5_ENST00000309879.5_Missense_Mutation_p.E327Q|ADCY5_ENST00000491190.1_Missense_Mutation_p.E310Q	NM_183357.2	NP_899200.1	O95622	ADCY5_HUMAN	adenylate cyclase 5	677					activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding			breast(2)|endometrium(4)|kidney(3)|large_intestine(12)|lung(22)|ovary(5)|prostate(2)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(2)	60				GBM - Glioblastoma multiforme(114;0.0342)		AAGGGGCGCTCAGCCCCCCAG	0.587000													4	72					0	0	0.014758	0	0
C17orf47	284083	broad.mit.edu	37	17	56621484	56621484	+	Missense_Mutation	SNP	T	T	G			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr17:56621484T>G	ENST00000321691.3	-	1	245	c.64A>C	c.(64-66)Act>Cct	p.T22P	RP11-112H10.4_ENST00000580769.1_RNA|RP11-112H10.4_ENST00000580589.1_RNA|RP11-112H10.4_ENST00000578022.1_RNA	NM_001038704.2	NP_001033793.2	Q8NEP4	CQ047_HUMAN	chromosome 17 open reading frame 47	22										NS(1)|breast(2)|endometrium(1)|kidney(4)|large_intestine(4)|lung(9)|prostate(1)|skin(1)|urinary_tract(1)	24	Medulloblastoma(34;0.127)|all_neural(34;0.237)					GTGTTAGTAGTAACCTCAGAC	0.512000													8	72					0	0	0.047766	0	0
KIF13A	63971	broad.mit.edu	37	6	17873668	17873668	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr6:17873668C>A	ENST00000378816.5	-	4	264	c.160G>T	c.(160-162)Gta>Tta	p.V54L	KIF13A_ENST00000378814.5_Splice_Site_p.V54_splice|KIF13A_ENST00000378826.2_Splice_Site_p.V54_splice|KIF13A_ENST00000378843.2_Splice_Site_p.V54_splice|KIF13A_ENST00000259711.6_Splice_Site_p.V54_splice			Q9H1H9	KI13A_HUMAN	kinesin family member 13A	54	Kinesin-motor.				cargo loading into vesicle|cell cycle|cytokinesis|endosome to lysosome transport|Golgi to plasma membrane protein transport|melanosome organization|plus-end-directed vesicle transport along microtubule	centrosome|endosome membrane|microtubule|midbody|trans-Golgi network membrane	ATP binding|microtubule motor activity|protein binding			breast(3)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(19)|lung(16)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	64	Breast(50;0.0107)|Ovarian(93;0.016)	all_hematologic(90;0.125)	all cancers(50;0.0865)|Epithelial(50;0.0974)			AAGGCAAATACCTGAATGAAA	0.353000													6	14					0.00116845	0.00148205	0.021553	1	0
TP53	7157	broad.mit.edu	37	17	7578555	7578555	+	Splice_Site	SNP	C	C	A			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr17:7578555C>A	ENST00000420246.2	-	5	508		c.e5-1		TP53_ENST00000413465.2_Splice_Site|TP53_ENST00000359597.4_Splice_Site|TP53_ENST00000269305.4_Splice_Site|TP53_ENST00000445888.2_Splice_Site|TP53_ENST00000455263.2_Splice_Site	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53						activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.?(39)|p.0?(8)|p.V73fs*9(1)|p.Y126fs*11(1)|p.P13fs*18(1)|p.T125_Y126insX(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CAGGGGAGTACTGTAGGAAGA	0.552000		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			4	43					0.00909568	0.0106177	0.009096	1	0
NKAIN2	154215	broad.mit.edu	37	6	124979487	124979487	+	Nonsense_Mutation	SNP	C	C	A			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr6:124979487C>A	ENST00000368417.1	+	4	489	c.429C>A	c.(427-429)taC>taA	p.Y143*	NKAIN2_ENST00000546092.1_Intron|NKAIN2_ENST00000368416.1_Nonsense_Mutation_p.Y143*|NKAIN2_ENST00000545433.1_Nonsense_Mutation_p.Y128*	NM_001040214.1	NP_001035304.1	Q5VXU1	NKAI2_HUMAN	Na+/K+ transporting ATPase interacting 2	143						integral to membrane|plasma membrane				cervix(1)|endometrium(1)|large_intestine(3)|lung(12)|skin(2)	19				GBM - Glioblastoma multiforme(226;0.104)		TGCTGGAGTACCAGTACATAG	0.532000													14	98					1.49906e-05	2.25243e-05	0.119110	1	0
LEPR	3953	broad.mit.edu	37	1	66074555	66074555	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr1:66074555G>A	ENST00000349533.6	+	12	1908	c.1723G>A	c.(1723-1725)Ggt>Agt	p.G575S	LEPR_ENST00000406510.3_Intron|LEPR_ENST00000462765.1_3'UTR|LEPR_ENST00000371058.1_Missense_Mutation_p.G575S|LEPR_ENST00000344610.8_Missense_Mutation_p.G575S|LEPR_ENST00000371060.3_Missense_Mutation_p.G575S|LEPR_ENST00000371059.3_Missense_Mutation_p.G575S	NM_002303.5	NP_002294.2	P48357	LEPR_HUMAN	leptin receptor	575	Fibronectin type-III 2.				energy reserve metabolic process|multicellular organismal development	extracellular region|integral to membrane|plasma membrane	cytokine receptor activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(22)|skin(2)	36				OV - Ovarian serous cystadenocarcinoma(397;0.00722)|KIRC - Kidney renal clear cell carcinoma(1967;0.094)		GATTCGCTATGGTTTAAGTGG	0.318000													6	63					0	0	0.021553	0	0
ADAM12	8038	broad.mit.edu	37	10	127760135	127760135	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr10:127760135G>C	ENST00000368679.4	-	12	1552	c.1243C>G	c.(1243-1245)Ctg>Gtg	p.L415V	ADAM12_ENST00000368676.4_Missense_Mutation_p.L415V	NM_003474.4	NP_003465.3	O43184	ADA12_HUMAN	ADAM metallopeptidase domain 12	415	Peptidase M12B.				cell adhesion|epidermal growth factor receptor signaling pathway|myoblast fusion|proteolysis	extracellular region|integral to membrane|plasma membrane	metalloendopeptidase activity|protein binding|SH3 domain binding|zinc ion binding			biliary_tract(1)|breast(7)|central_nervous_system(4)|endometrium(5)|kidney(3)|large_intestine(11)|liver(1)|lung(24)|ovary(2)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	69		all_epithelial(44;7.06e-05)|all_lung(145;0.00563)|Lung NSC(174;0.00834)|Colorectal(57;0.102)|all_neural(114;0.107)|Breast(234;0.22)		COAD - Colon adenocarcinoma(40;0.141)|Colorectal(40;0.216)		ACTTCCGGCAGGTTAAACAGG	0.542000													12	169					0	0	0.093190	0	0
EXPH5	23086	broad.mit.edu	37	11	108398907	108398907	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr11:108398907C>T	ENST00000265843.4	-	4	558	c.448G>A	c.(448-450)Gat>Aat	p.D150N	EXPH5_ENST00000428840.1_Missense_Mutation_p.D74N|EXPH5_ENST00000524840.1_5'UTR|EXPH5_ENST00000443411.1_Intron|EXPH5_ENST00000525344.1_Missense_Mutation_p.D143N	NM_015065.2	NP_055880.2	Q149M6	Q149M6_HUMAN	exophilin 5	150					intracellular protein transport		Rab GTPase binding			breast(3)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(13)|liver(1)|lung(34)|ovary(3)|pancreas(2)|prostate(2)|skin(11)|stomach(3)|upper_aerodigestive_tract(1)	91		all_cancers(61;3.99e-08)|Acute lymphoblastic leukemia(157;3.97e-05)|Melanoma(852;4.04e-05)|all_epithelial(67;0.000116)|all_hematologic(158;0.000315)|Breast(348;0.104)|all_neural(303;0.16)		Epithelial(105;8.1e-06)|BRCA - Breast invasive adenocarcinoma(274;1.22e-05)|all cancers(92;0.000129)|OV - Ovarian serous cystadenocarcinoma(223;0.11)|Colorectal(284;0.184)		GCATGGCCATCACATCTGTGG	0.403000													6	92					0	0	0.029380	0	0
GRID2	2895	broad.mit.edu	37	4	94690496	94690496	+	Silent	SNP	A	A	T			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr4:94690496A>T	ENST00000282020.4	+	15	2754	c.2496A>T	c.(2494-2496)gcA>gcT	p.A832A	GRID2_ENST00000510992.1_Silent_p.A737A	NM_001510.2	NP_001501.2	O43424	GRID2_HUMAN	glutamate receptor, ionotropic, delta 2	832					glutamate signaling pathway	cell junction|integral to plasma membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			NS(2)|breast(2)|central_nervous_system(1)|endometrium(6)|kidney(4)|large_intestine(18)|lung(45)|ovary(3)|prostate(6)|skin(9)|upper_aerodigestive_tract(3)|urinary_tract(1)	100		Hepatocellular(203;0.114)|all_hematologic(202;0.177)		OV - Ovarian serous cystadenocarcinoma(123;3.22e-06)|LUSC - Lung squamous cell carcinoma(81;0.185)|Lung(65;0.191)	L-Glutamic Acid(DB00142)	AGAGCTTTGCAGGGGTCTTTT	0.527000													18	78					0	0	0.062417	0	0
ILDR2	387597	broad.mit.edu	37	1	166904656	166904656	+	Silent	SNP	G	G	T			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr1:166904656G>T	ENST00000271417.3	-	6	817	c.762C>A	c.(760-762)ccC>ccA	p.P254P	ILDR2_ENST00000526687.1_Intron|ILDR2_ENST00000528703.1_Intron|ILDR2_ENST00000529071.1_Silent_p.P235P|ILDR2_ENST00000469934.2_Silent_p.P254P|ILDR2_ENST00000529387.1_Intron|ILDR2_ENST00000525740.1_Intron	NM_199351.2	NP_955383.1	Q71H61	ILDR2_HUMAN	immunoglobulin-like domain containing receptor 2	254						integral to membrane				NS(3)|breast(1)|kidney(2)|large_intestine(2)|lung(9)|ovary(1)|skin(2)|upper_aerodigestive_tract(2)	22						AGTAAGGGCCGGGGACACCGG	0.592000													4	80					0.00024832	0.000335289	0.009096	1	0
C19orf57	79173	broad.mit.edu	37	19	13996797	13996797	+	Silent	SNP	A	A	T			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr19:13996797A>T	ENST00000454313.1	-	7	1798	c.1740T>A	c.(1738-1740)gtT>gtA	p.V580V	C19orf57_ENST00000591586.1_Silent_p.V155V|C19orf57_ENST00000586783.1_Silent_p.V580V|C19orf57_ENST00000346736.2_Silent_p.V580V			Q0VDD7	CS057_HUMAN	chromosome 19 open reading frame 57	580					multicellular organismal development		protein binding			breast(2)|kidney(1)|lung(3)|ovary(4)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	14			OV - Ovarian serous cystadenocarcinoma(19;2e-21)			TGGCCACTGCAACAGGGTCTC	0.597000													5	21					0	0	0.021553	0	0
VDR	7421	broad.mit.edu	37	12	48238661	48238661	+	Silent	SNP	G	G	A			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr12:48238661G>A	ENST00000229022.3	-	11	1433	c.1152C>T	c.(1150-1152)atC>atT	p.I384I	VDR_ENST00000550325.1_Silent_p.I434I|VDR_ENST00000549336.1_Silent_p.I384I|VDR_ENST00000395324.2_Silent_p.I384I|VDR_ENST00000535672.1_Silent_p.I352I	NM_001017535.1	NP_001017535.1	P11473	VDR_HUMAN	vitamin D (1,25- dihydroxyvitamin D3) receptor	384	Ligand-binding.				decidualization|negative regulation of cell proliferation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of vitamin D 24-hydroxylase activity|regulation of calcidiol 1-monooxygenase activity|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	retinoid X receptor binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|vitamin D3 receptor activity|zinc ion binding			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(10)|ovary(3)|skin(2)	22		Acute lymphoblastic leukemia(13;0.109)|all_hematologic(14;0.214)		GBM - Glioblastoma multiforme(48;0.17)	Calcidiol(DB00146)|Calcipotriol(DB02300)|Calcitriol(DB00136)|Dihydrotachysterol(DB01070)|Ergocalciferol(DB00153)|Paricalcitol(DB00910)	CTAGCTTCTGGATCATCTTGG	0.617000													4	48					0	0	0.009096	0	0
TFAP2D	83741	broad.mit.edu	37	6	50686809	50686809	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr6:50686809G>A	ENST00000008391.3	+	3	772	c.544G>A	c.(544-546)Gtg>Atg	p.V182M	TFAP2D_ENST00000492804.1_3'UTR	NM_172238.3	NP_758438.2	Q7Z6R9	AP2D_HUMAN	transcription factor AP-2 delta (activating enhancer binding protein 2 delta)	182							DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|biliary_tract(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(12)|lung(26)|ovary(6)|pancreas(1)|prostate(5)|stomach(1)	60	Lung NSC(77;0.0334)					TAAGGGCTCTGTGGAGGCCCA	0.403000													6	38					0	0	0.021553	0	0
A1CF	29974	broad.mit.edu	37	10	52595851	52595851	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr10:52595851C>A	ENST00000395489.2	-	8	962	c.566G>T	c.(565-567)aGg>aTg	p.R189M	A1CF_ENST00000373993.1_Missense_Mutation_p.R196M|A1CF_ENST00000373995.3_Missense_Mutation_p.R204M|A1CF_ENST00000395495.1_Missense_Mutation_p.R196M|A1CF_ENST00000373997.3_Missense_Mutation_p.R196M|A1CF_ENST00000374001.1_Missense_Mutation_p.R196M|A1CF_ENST00000282641.2_Missense_Mutation_p.R196M	NM_001198819.1	NP_001185748.1	Q9NQ94	A1CF_HUMAN	APOBEC1 complementation factor	196	RRM 2.				cytidine to uridine editing|mRNA modification|mRNA processing|protein stabilization	apolipoprotein B mRNA editing enzyme complex|endoplasmic reticulum|nucleoplasm	nucleotide binding|protein binding|single-stranded RNA binding			NS(1)|breast(1)|central_nervous_system(1)|kidney(3)|large_intestine(4)|lung(14)|prostate(2)|skin(3)	29						CAGTTTCCTCCTCGCCATGGC	0.478000													12	112					4.7546e-09	8.0526e-09	0.146539	1	0
LRFN2	57497	broad.mit.edu	37	6	40360441	40360441	+	Silent	SNP	G	G	A			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr6:40360441G>A	ENST00000338305.6	-	3	2153	c.1611C>T	c.(1609-1611)gtC>gtT	p.V537V		NM_020737.1	NP_065788.1	Q9ULH4	LRFN2_HUMAN	leucine rich repeat and fibronectin type III domain containing 2	537						cell junction|integral to membrane|postsynaptic membrane				breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(13)|lung(25)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	58	Ovarian(28;0.0418)|Colorectal(47;0.196)					TGCCCCCGATGACCAGGATCA	0.617000													6	60					0	0	0.038147	0	0
FGFR2	2263	broad.mit.edu	37	10	123243279	123243279	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr10:123243279G>T	ENST00000358487.5	-	17	2506	c.2234C>A	c.(2233-2235)tCc>tAc	p.S745Y	FGFR2_ENST00000356226.4_Missense_Mutation_p.S628Y|FGFR2_ENST00000351936.6_Missense_Mutation_p.S743Y|FGFR2_ENST00000369059.1_Missense_Mutation_p.S631Y|FGFR2_ENST00000457416.2_Missense_Mutation_p.S746Y|FGFR2_ENST00000369061.4_Missense_Mutation_p.S633Y|FGFR2_ENST00000346997.2_Missense_Mutation_p.S743Y|FGFR2_ENST00000357555.5_Missense_Mutation_p.S656Y|FGFR2_ENST00000369056.1_Missense_Mutation_p.S746Y|FGFR2_ENST00000478859.1_Missense_Mutation_p.S517Y|FGFR2_ENST00000369060.4_Missense_Mutation_p.S629Y|FGFR2_ENST00000360144.3_Missense_Mutation_p.S657Y	NM_000141.4	NP_000132.3	P21802	FGFR2_HUMAN	fibroblast growth factor receptor 2	745	Protein kinase.				angiogenesis|axonogenesis|bone mineralization|bone morphogenesis|branch elongation involved in salivary gland morphogenesis|branching involved in embryonic placenta morphogenesis|branching morphogenesis of a nerve|bud elongation involved in lung branching|cell fate commitment|cell growth|cell-cell signaling|cellular response to protein stimulus|embryonic digestive tract morphogenesis|embryonic pattern specification|epithelial cell proliferation involved in salivary gland morphogenesis|fibroblast growth factor receptor signaling pathway involved in hemopoiesis|fibroblast growth factor receptor signaling pathway involved in mammary gland specification|fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptosis in bone marrow|fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development|fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow|hair follicle morphogenesis|insulin receptor signaling pathway|lacrimal gland development|lateral sprouting from an epithelium|limb bud formation|lung alveolus development|lung lobe morphogenesis|lung-associated mesenchyme development|mammary gland bud formation|membranous septum morphogenesis|mesenchymal cell differentiation involved in lung development|mesenchymal cell proliferation involved in lung development|midbrain development|multicellular organism growth|negative regulation of transcription from RNA polymerase II promoter|odontogenesis|organ growth|otic vesicle formation|outflow tract septum morphogenesis|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cardiac muscle cell proliferation|positive regulation of cell cycle|positive regulation of cell division|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of ERK1 and ERK2 cascade|positive regulation of mesenchymal cell proliferation|positive regulation of transcription from RNA polymerase II promoter|post-embryonic development|prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis|prostate epithelial cord elongation|pyramidal neuron development|regulation of branching involved in prostate gland morphogenesis|regulation of cell fate commitment|regulation of fibroblast growth factor receptor signaling pathway|regulation of multicellular organism growth|regulation of smooth muscle cell differentiation|regulation of smoothened signaling pathway|squamous basal epithelial stem cell differentiation involved in prostate gland acinus development|ureteric bud development|ventricular cardiac muscle tissue morphogenesis|ventricular zone neuroblast division	cell cortex|cell surface|excitatory synapse|extracellular region|integral to membrane|nucleus|plasma membrane	ATP binding|fibroblast growth factor binding|fibroblast growth factor receptor activity|heparin binding|protein binding			breast(3)|central_nervous_system(3)|cervix(2)|endometrium(98)|haematopoietic_and_lymphoid_tissue(4)|kidney(4)|large_intestine(7)|lung(21)|ovary(4)|skin(30)|soft_tissue(1)|stomach(2)|upper_aerodigestive_tract(2)	181		Lung NSC(174;0.0841)|all_lung(145;0.106)|all_neural(114;0.107)	STAD - Stomach adenocarcinoma(1;7.52e-05)|all cancers(1;0.0722)	all cancers(201;9.73e-05)|GBM - Glioblastoma multiforme(135;0.0845)	Palifermin(DB00039)	TGGTCTCTGGGAGGGCACTGC	0.448000		5	Mis		"""gastric. NSCLC, endometrial"""		"""Crouzon, Pfeiffer, and Apert syndromes"""		Saethre-Chotzen syndrome;Apert syndrome				3	29					0.004672	0.0056566	0.115264	1	0
GAS2L3	283431	broad.mit.edu	37	12	101018250	101018250	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr12:101018250C>T	ENST00000537247.1	+	10	2309	c.1355C>T	c.(1354-1356)tCg>tTg	p.S452L	GAS2L3_ENST00000266754.5_Missense_Mutation_p.S556L|GAS2L3_ENST00000539410.1_Missense_Mutation_p.S556L|GAS2L3_ENST00000547754.1_Missense_Mutation_p.S556L			Q86XJ1	GA2L3_HUMAN	growth arrest-specific 2 like 3	556					cell cycle arrest					endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(15)|pancreas(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	35						AAACTTAAATCGGCCTTGAAT	0.433000													5	24					0	0	0.029380	0	0
NID2	22795	broad.mit.edu	37	14	52486794	52486794	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr14:52486794C>G	ENST00000216286.5	-	13	2776	c.2777G>C	c.(2776-2778)gGa>gCa	p.G926A	NID2_ENST00000541773.1_Missense_Mutation_p.G825A	NM_007361.3	NP_031387.3	Q14112	NID2_HUMAN	nidogen 2 (osteonidogen)	926	EGF-like 5; calcium-binding (Potential).					basement membrane	calcium ion binding|collagen binding			NS(1)|breast(5)|endometrium(9)|kidney(4)|large_intestine(11)|liver(1)|lung(40)|ovary(2)|pancreas(2)|prostate(2)|skin(3)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	87	Breast(41;0.0639)|all_epithelial(31;0.123)					GCACTGAAATCCATCCCCATA	0.453000													5	101					0	0	0.038147	0	0
KCNC2	3747	broad.mit.edu	37	12	75441978	75441978	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr12:75441978T>A	ENST00000549446.1	-	4	2415	c.1735A>T	c.(1735-1737)Acg>Tcg	p.T579S	KCNC2_ENST00000393288.2_Missense_Mutation_p.T579S|KCNC2_ENST00000550433.1_Missense_Mutation_p.T579S|KCNC2_ENST00000341669.3_Missense_Mutation_p.T579S|KCNC2_ENST00000298972.1_Missense_Mutation_p.T579S|KCNC2_ENST00000540018.1_Intron|KCNC2_ENST00000548513.1_Missense_Mutation_p.T579S|KCNC2_ENST00000350228.2_Intron	NM_001260497.1|NM_139137.3	NP_001247426.1|NP_631875.1	Q96PR1	KCNC2_HUMAN	potassium voltage-gated channel, Shaw-related subfamily, member 2	579					energy reserve metabolic process|regulation of insulin secretion	voltage-gated potassium channel complex	voltage-gated potassium channel activity			breast(3)|endometrium(4)|kidney(1)|large_intestine(9)|liver(1)|lung(28)|ovary(1)|pancreas(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	54						TCACCTGTCGTCAGTAGGAAA	0.468000													7	193					0	0	0.047766	0	0
MUC16	94025	broad.mit.edu	37	19	9085343	9085343	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr19:9085343C>T	ENST00000397910.4	-	1	6675	c.6472G>A	c.(6472-6474)Ggc>Agc	p.G2158S		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	2158	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GATGTAAGGCCAGAAACATCT	0.488000													17	89					0	0	0.038395	0	0
NRP2	8828	broad.mit.edu	37	2	206590765	206590765	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr2:206590765G>T	ENST00000360409.3	+	6	1740	c.949G>T	c.(949-951)Ggc>Tgc	p.G317C	NRP2_ENST00000540178.1_Missense_Mutation_p.G317C|NRP2_ENST00000357785.5_Missense_Mutation_p.G317C|NRP2_ENST00000412873.2_Missense_Mutation_p.G317C|NRP2_ENST00000357118.4_Missense_Mutation_p.G317C|NRP2_ENST00000272849.3_Missense_Mutation_p.G317C|NRP2_ENST00000540841.1_Missense_Mutation_p.G317C|NRP2_ENST00000417189.1_Missense_Mutation_p.G317C|NRP2_ENST00000355117.4_Missense_Mutation_p.G317C	NM_003872.2|NM_201266.1|NM_201279.1	NP_003863.2|NP_957718.1|NP_958436.1	O60462	NRP2_HUMAN	neuropilin 2	317	F5/8 type C 1.				angiogenesis|axon guidance|cell adhesion	integral to membrane|membrane fraction|plasma membrane	heparin binding|metal ion binding|semaphorin receptor activity|vascular endothelial growth factor receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(14)|lung(19)|ovary(1)|pancreas(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(2)	52						TGATGACAATGGCTGGACCCC	0.522000													5	47					4.096e-09	6.97749e-09	0.021553	1	0
C2orf83	56918	broad.mit.edu	37	2	228476173	228476173	+	Silent	SNP	T	T	G			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr2:228476173T>G	ENST00000264387.4	-	3	476	c.390A>C	c.(388-390)acA>acC	p.T130T	C2orf83_ENST00000409066.1_3'UTR	NM_020161.3	NP_064546.3	Q53S99	CB083_HUMAN	chromosome 2 open reading frame 83	130						membrane	folic acid binding|reduced folate carrier activity			endometrium(1)|kidney(1)|large_intestine(1)|lung(6)|stomach(2)	11						TCTTGTTCTCTGTGGACTTTT	0.517000													8	73					0	0	0.058154	0	0
MIR124-2HG	100130155	broad.mit.edu	37	8	65291870	65291870	+	RNA	SNP	G	G	T			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr8:65291870G>T	ENST00000521441.1	+	0	655																											AGGGAATTTAGGGGGTAGTAA	0.542000													3	13					6.4e-05	9.28521e-05	0.115264	1	0
SMOC1	64093	broad.mit.edu	37	14	70490074	70490074	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr14:70490074G>C	ENST00000381280.4	+	11	1454	c.1201G>C	c.(1201-1203)Gcc>Ccc	p.A401P	SMOC1_ENST00000361956.3_Missense_Mutation_p.A401P	NM_001034852.2|NM_022137.5	NP_001030024.1|NP_071420.1	Q9H4F8	SMOC1_HUMAN	SPARC related modular calcium binding 1	401	EF-hand 2.				cell differentiation|eye development|limb development|regulation of osteoblast differentiation|signal transduction	basement membrane	calcium ion binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(10)|ovary(1)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	21				all cancers(60;0.00417)|BRCA - Breast invasive adenocarcinoma(234;0.0119)|OV - Ovarian serous cystadenocarcinoma(108;0.028)		CAAGAAATGTGCCCGGCGTTT	0.517000													20	251					0	0	0.049695	0	0
ANK3	288	broad.mit.edu	37	10	61822989	61822989	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr10:61822989T>C	ENST00000280772.1	-	40	12666	c.12475A>G	c.(12475-12477)Aca>Gca	p.T4159A	ANK3_ENST00000373827.2_Missense_Mutation_p.T1540A|ANK3_ENST00000355288.2_Missense_Mutation_p.T680A|ANK3_ENST00000503366.1_Missense_Mutation_p.T1547A	NM_020987.3	NP_066267.2	Q12955	ANK3_HUMAN	ankyrin 3, node of Ranvier (ankyrin G)	4159	Death.				establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						TTAATTTTTGTCAAGACCGAA	0.343000													7	34					0	0	0.038147	0	0
TMEM182	130827	broad.mit.edu	37	2	103414410	103414410	+	Silent	SNP	C	C	T	rs140175654	byFrequency	TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr2:103414410C>T	ENST00000412401.2	+	4	625	c.420C>T	c.(418-420)ttC>ttT	p.F140F	TMEM182_ENST00000486293.1_3'UTR|TMEM182_ENST00000409173.1_Silent_p.F97F|TMEM182_ENST00000409528.1_Silent_p.F44F	NM_144632.3	NP_653233.3	Q6ZP80	TM182_HUMAN	transmembrane protein 182	140						integral to membrane				breast(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(5)	11						CAGCCCCCTTCGCCAGCCATT	0.517000													4	53					0	0	0.014758	0	0
SLC15A1	6564	broad.mit.edu	37	13	99336994	99336994	+	Nonsense_Mutation	SNP	G	G	C			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr13:99336994G>C	ENST00000376503.5	-	23	2166	c.2111C>G	c.(2110-2112)tCa>tGa	p.S704*		NM_005073.3	NP_005064.1	P46059	S15A1_HUMAN	solute carrier family 15 (oligopeptide transporter), member 1	704					digestion|protein transport	integral to plasma membrane|membrane fraction	peptide:hydrogen symporter activity			breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(6)|lung(10)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	30	all_neural(89;0.101)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)				Cefadroxil(DB01140)|Ceftibuten(DB01415)|Cyclacillin(DB01000)	CTGTTTCTGTGAATTGGCCCC	0.502000													6	28					0	0	0.029380	0	0
SLC39A12	221074	broad.mit.edu	37	10	18242341	18242341	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr10:18242341C>A	ENST00000377369.2	+	2	409	c.136C>A	c.(136-138)Ctg>Atg	p.L46M	SLC39A12_ENST00000377374.4_Missense_Mutation_p.L46M|SLC39A12_ENST00000377371.3_Missense_Mutation_p.L46M|SLC39A12_ENST00000539911.1_Intron	NM_001145195.1	NP_001138667.1	Q504Y0	S39AC_HUMAN	solute carrier family 39 (zinc transporter), member 12	46					zinc ion transport	integral to membrane	metal ion transmembrane transporter activity			NS(1)|breast(4)|central_nervous_system(1)|cervix(1)|kidney(3)|large_intestine(5)|lung(38)|ovary(3)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	60						ACCGGCAGACCTGCTACAGGT	0.527000													4	57					0.00909568	0.0106177	0.009096	1	0
HOMER1	9456	broad.mit.edu	37	5	78752776	78752776	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr5:78752776C>A	ENST00000334082.6	-	2	1513	c.71G>T	c.(70-72)tGg>tTg	p.W24L	HOMER1_ENST00000282260.6_Missense_Mutation_p.W24L|HOMER1_ENST00000508576.1_Missense_Mutation_p.W24L|HOMER1_ENST00000535690.1_Intron	NM_004272.3	NP_004263.1	Q86YM7	HOME1_HUMAN	homer homolog 1 (Drosophila)	24	WH1.				activation of phospholipase C activity by metabotropic glutamate receptor signaling pathway|synaptic transmission	cell junction|integral to plasma membrane|postsynaptic density|postsynaptic membrane				endometrium(2)|kidney(1)|large_intestine(5)|lung(3)|prostate(2)|skin(1)	14		Lung NSC(167;0.00131)|all_lung(232;0.00151)|Ovarian(174;0.0261)|Prostate(461;0.191)		OV - Ovarian serous cystadenocarcinoma(54;1.87e-44)|Epithelial(54;7.07e-41)|all cancers(79;5.5e-36)		GGTGGGTACCCAGTTCTTCTT	0.428000													12	125					6.40141e-05	9.28521e-05	0.080935	1	0
LRRC66	339977	broad.mit.edu	37	4	52861613	52861613	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr4:52861613C>G	ENST00000343457.3	-	4	1581	c.1575G>C	c.(1573-1575)caG>caC	p.Q525H		NM_001024611.1	NP_001019782.1	Q68CR7	LRC66_HUMAN	leucine rich repeat containing 66	525						integral to membrane				central_nervous_system(1)|endometrium(9)|kidney(1)|large_intestine(8)|lung(34)|ovary(1)|pancreas(1)|prostate(2)|skin(1)	58						GGATGTGGTCCTGCGCTGCTG	0.512000													12	128					0	0	0.093190	0	0
MED28	80306	broad.mit.edu	37	4	17616422	17616422	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr4:17616422G>A	ENST00000237380.6	+	1	169	c.145G>A	c.(145-147)Gag>Aag	p.E49K		NM_025205.3	NP_079481.2	Q9H204	MED28_HUMAN	mediator complex subunit 28	49					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|membrane|nucleus	actin binding			lung(6)|skin(2)	8						GGACGAGTTGGAGTCATCTTT	0.567000													10	86					0	0	0.069234	0	0
CNGB3	54714	broad.mit.edu	37	8	87679272	87679272	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr8:87679272G>T	ENST00000320005.5	-	6	780	c.733C>A	c.(733-735)Caa>Aaa	p.Q245K		NM_019098.4	NP_061971.3	Q9NQW8	CNGB3_HUMAN	cyclic nucleotide gated channel beta 3	245					signal transduction|visual perception	integral to membrane	cGMP binding	p.Q245E(1)		NS(1)|breast(2)|endometrium(4)|kidney(6)|large_intestine(15)|lung(44)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	80						TCTGCGGTTTGATATGGGAAG	0.433000													9	73					1.33987e-11	2.42335e-11	0.069234	1	0
C3orf79	152118	broad.mit.edu	37	3	153202422	153202422	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr3:153202422A>G	ENST00000446603.2	+	1	139	c.77A>G	c.(76-78)cAt>cGt	p.H26R	RP11-23D24.2_ENST00000493214.2_RNA	NM_001101337.1	NP_001094807.1	P0CE67	CC079_HUMAN	chromosome 3 open reading frame 79	26										endometrium(1)|large_intestine(3)	4						TTCAGTTGCCATCTTCTGCCT	0.413000													13	290					0	0	0.119110	0	0
ERBB4	2066	broad.mit.edu	37	2	212589829	212589829	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr2:212589829C>A	ENST00000342788.4	-	6	1023	c.713G>T	c.(712-714)tGc>tTc	p.C238F	ERBB4_ENST00000436443.1_Missense_Mutation_p.C238F|ERBB4_ENST00000402597.1_Missense_Mutation_p.C238F	NM_005235.2	NP_005226.1	Q15303	ERBB4_HUMAN	v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 4	238	Cys-rich.				cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent|transmembrane receptor protein tyrosine kinase signaling pathway	basolateral plasma membrane|cytoplasm|integral to membrane|nucleus	ATP binding|protein binding|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			NS(1)|breast(7)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(31)|lung(71)|pancreas(1)|prostate(3)|skin(39)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	179		Renal(323;0.06)|Lung NSC(271;0.197)		UCEC - Uterine corpus endometrioid carcinoma (47;0.214)|Epithelial(149;5.86e-06)|all cancers(144;2.95e-05)|Lung(261;0.00244)|LUSC - Lung squamous cell carcinoma(224;0.00266)		AGGTCCTGAGCAGCCTCCAGC	0.478000										TSP Lung(8;0.080)			8	71					0.00307968	0.0038235	0.038147	1	0
PTPRD	5789	broad.mit.edu	37	9	8518184	8518184	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr9:8518184G>T	ENST00000381196.4	-	18	1750	c.1207C>A	c.(1207-1209)Cct>Act	p.P403T	PTPRD_ENST00000358503.5_Missense_Mutation_p.P390T|PTPRD_ENST00000356435.5_Missense_Mutation_p.P403T|PTPRD_ENST00000397617.3_Missense_Mutation_p.P393T|PTPRD_ENST00000540109.1_Missense_Mutation_p.P403T|PTPRD_ENST00000355233.5_Missense_Mutation_p.P403T|PTPRD_ENST00000397606.3_Missense_Mutation_p.P393T|PTPRD_ENST00000360074.4_Missense_Mutation_p.P390T|PTPRD_ENST00000397611.3_Missense_Mutation_p.P400T|PTPRD_ENST00000486161.1_Missense_Mutation_p.P403T|PTPRD_ENST00000537002.1_Missense_Mutation_p.P400T	NM_002839.3	NP_002830.1	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	403	Fibronectin type-III 1.				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(7)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|liver(1)|lung(83)|ovary(4)|pancreas(1)|prostate(7)|skin(19)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	168		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		TCGCTGGGAGGCCCCCGCCCA	0.537000										TSP Lung(15;0.13)			11	77					0.010729	0.0124746	0.080935	1	0
LTV1	84946	broad.mit.edu	37	6	144167209	144167209	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr6:144167209G>A	ENST00000367576.5	+	3	291	c.157G>A	c.(157-159)Gca>Aca	p.A53T		NM_032860.3	NP_116249.2	Q96GA3	LTV1_HUMAN	LTV1 homolog (S. cerevisiae)	53										breast(2)|endometrium(1)|large_intestine(2)|lung(5)|ovary(2)|prostate(1)	13				OV - Ovarian serous cystadenocarcinoma(155;2.72e-06)|GBM - Glioblastoma multiforme(68;0.0372)		AGAAAGGCGAGCAGAACAGAG	0.413000													4	63					0	0	0.009096	0	0
RAB33A	9363	broad.mit.edu	37	X	129306262	129306262	+	Missense_Mutation	SNP	A	A	C			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chrX:129306262A>C	ENST00000257017.4	+	1	640	c.226A>C	c.(226-228)Aag>Cag	p.K76Q		NM_004794.2	NP_004785.1	Q14088	RB33A_HUMAN	RAB33A, member RAS oncogene family	76					protein transport|small GTPase mediated signal transduction	plasma membrane	GTP binding|GTPase activity|protein binding			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(5)	11						CTTCAGGGAGAAGACCGTGGA	0.622000													6	67					0	0	0.021553	0	0
SLC9C2	284525	broad.mit.edu	37	1	173502880	173502880	+	Silent	SNP	A	A	G			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr1:173502880A>G	ENST00000367714.3	-	17	2453	c.2031T>C	c.(2029-2031)ttT>ttC	p.F677F	SLC9C2_ENST00000536496.1_3'UTR|SLC9C2_ENST00000466087.1_5'UTR	NM_178527.3	NP_848622.2	Q5TAH2	S9A11_HUMAN	solute carrier family 9, member C2 (putative)	677	Ion transport-like (By similarity).				sodium ion transport	integral to membrane	ion channel activity|solute:hydrogen antiporter activity										TAACCAGGATAAAAAATTCCA	0.289000													9	65					0	0	0.058154	0	0
HRNR	388697	broad.mit.edu	37	1	152193257	152193257	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr1:152193257T>C	ENST00000368801.2	-	3	923	c.848A>G	c.(847-849)tAt>tGt	p.Y283C	FLG-AS1_ENST00000593011.1_RNA|FLG-AS1_ENST00000420707.1_RNA	NM_001009931.1	NP_001009931.1	Q86YZ3	HORN_HUMAN	hornerin	283					keratinization		calcium ion binding|protein binding			autonomic_ganglia(1)|breast(6)|central_nervous_system(2)|cervix(2)|endometrium(22)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(19)|liver(1)|lung(84)|ovary(5)|prostate(6)|skin(12)|stomach(9)|upper_aerodigestive_tract(5)|urinary_tract(6)	192	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			ATGCTGACCATAGCTGGAAGA	0.592000													6	92					0	0	0.038147	0	0
FOXJ1	2302	broad.mit.edu	37	17	74134191	74134191	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr17:74134191C>A	ENST00000322957.6	-	3	863	c.509G>T	c.(508-510)cGc>cTc	p.R170L		NM_001454.3	NP_001445.2	Q92949	FOXJ1_HUMAN	forkhead box J1	170					actin cytoskeleton organization|activation of Rho GTPase activity|central tolerance induction|cilium assembly|epithelial cell differentiation|establishment of apical/basal cell polarity|heart looping|humoral immune response|left/right pattern formation|leukocyte migration|lung development|negative regulation of B cell activation|negative regulation of germinal center formation|negative regulation of humoral immune response mediated by circulating immunoglobulin|negative regulation of interleukin-6 biosynthetic process|negative regulation of NF-kappaB transcription factor activity|negative regulation of T cell differentiation in thymus|negative regulation of T cell proliferation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of central B cell tolerance induction|spermatogenesis	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|protein domain specific binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			large_intestine(1)|liver(1)|pancreas(1)|skin(1)	4			LUSC - Lung squamous cell carcinoma(166;0.187)			CAGGTTGTGGCGGATTGAATT	0.602000													3	17					0.014758	0.017024	0.014758	1	0
OSBPL6	114880	broad.mit.edu	37	2	179250197	179250197	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr2:179250197C>A	ENST00000190611.4	+	19	2402	c.2026C>A	c.(2026-2028)Cca>Aca	p.P676T	OSBPL6_ENST00000315022.2_Missense_Mutation_p.P680T|OSBPL6_ENST00000359685.3_Missense_Mutation_p.P640T|OSBPL6_ENST00000409631.1_Missense_Mutation_p.P640T|OSBPL6_ENST00000392505.2_Missense_Mutation_p.P701T|OSBPL6_ENST00000409045.3_Missense_Mutation_p.P645T	NM_032523.3	NP_115912.1	Q9BZF3	OSBL6_HUMAN	oxysterol binding protein-like 6	676					lipid transport		lipid binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(13)|lung(18)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	46			OV - Ovarian serous cystadenocarcinoma(117;0.00578)|Epithelial(96;0.00847)|all cancers(119;0.0335)			TAGCCATCATCCACCCATTTC	0.323000													8	65					1.76689e-08	2.90843e-08	0.058154	1	0
KCNH4	23415	broad.mit.edu	37	17	40317475	40317475	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr17:40317475C>T	ENST00000264661.3	-	11	2409	c.2077G>A	c.(2077-2079)Gac>Aac	p.D693N	KCNH4_ENST00000607371.1_Missense_Mutation_p.D693N	NM_012285.2	NP_036417.1	Q9UQ05	KCNH4_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 4	693					regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	two-component sensor activity|voltage-gated potassium channel activity			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(6)|lung(15)|skin(2)|urinary_tract(1)	32		all_cancers(22;1.24e-06)|all_epithelial(22;4.33e-05)|Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.126)		ACACTGGTGTCAGAGCCCTGG	0.632000													5	157					0	0	0.014758	0	0
PPARGC1A	10891	broad.mit.edu	37	4	23803432	23803432	+	Silent	SNP	C	C	T			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr4:23803432C>T	ENST00000264867.2	-	12	2333	c.2214G>A	c.(2212-2214)ttG>ttA	p.L738L	PPARGC1A_ENST00000509702.1_5'UTR	NM_013261.3	NP_037393.1	Q9UBK2	PRGC1_HUMAN	peroxisome proliferator-activated receptor gamma, coactivator 1 alpha	738	RRM.				androgen receptor signaling pathway|brown fat cell differentiation|cellular glucose homeostasis|digestion|fatty acid oxidation|gluconeogenesis|mitochondrion organization|mRNA processing|neuron death|positive regulation of fatty acid oxidation|positive regulation of gluconeogenesis|positive regulation of histone acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|protein complex assembly|protein stabilization|response to muscle activity|response to starvation|RNA splicing|temperature homeostasis|transcription initiation from RNA polymerase II promoter	DNA-directed RNA polymerase II, core complex	androgen receptor binding|DNA binding|ligand-dependent nuclear receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|nucleotide binding|RNA binding|RNA polymerase II transcription cofactor activity|transcription factor binding			central_nervous_system(1)|endometrium(7)|kidney(3)|large_intestine(7)|liver(1)|lung(24)|ovary(3)|skin(5)	51		Breast(46;0.0503)				TTGACCTGCGCAAAGTGTATC	0.408000													7	63					0	0	0.047766	0	0
CLTC	1213	broad.mit.edu	37	17	57759112	57759112	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr17:57759112A>T	ENST00000269122.3	+	21	3628	c.3354A>T	c.(3352-3354)aaA>aaT	p.K1118N	CLTC_ENST00000393043.1_Missense_Mutation_p.K1118N|CLTC_ENST00000579456.1_Intron	NM_004859.3	NP_004850.1	Q00610	CLH1_HUMAN	clathrin, heavy chain (Hc)	1118	Heavy chain arm.|Proximal segment.				axon guidance|epidermal growth factor receptor signaling pathway|intracellular protein transport|mitosis|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|post-Golgi vesicle-mediated transport|receptor internalization|transferrin transport	clathrin coat of coated pit|clathrin coat of trans-Golgi network vesicle|cytosol|melanosome|spindle	protein binding|structural molecule activity		CLTC/ALK(44)|CLTC/TFE3(2)	breast(2)|large_intestine(6)|ovary(1)	9	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)					AGTTGCAGAAAGGAATGGTGA	0.428000			T	"""ALK, TFE3"""	"""ALCL, renal """								6	37					0	0	0.021553	0	0
CLCA1	1179	broad.mit.edu	37	1	86957029	86957029	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr1:86957029G>T	ENST00000234701.3	+	10	1790	c.1439G>T	c.(1438-1440)gGa>gTa	p.G480V	CLCA1_ENST00000394711.1_Missense_Mutation_p.G480V			A8K7I4	CLCA1_HUMAN	chloride channel accessory 1	480					calcium ion transport	extracellular space|integral to plasma membrane	chloride channel activity			NS(1)|breast(3)|endometrium(1)|kidney(3)|large_intestine(9)|lung(14)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	38		Lung NSC(277;0.239)		all cancers(265;0.0249)|Epithelial(280;0.0476)		TCAGGAAATGGAGCTGTCTCT	0.388000													7	71					0.0293803	0.0327317	0.029380	1	0
GPR98	84059	broad.mit.edu	37	5	90040916	90040916	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr5:90040916G>A	ENST00000405460.2	+	51	10699	c.10603G>A	c.(10603-10605)Gag>Aag	p.E3535K		NM_032119.3	NP_115495.3	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98	3535					cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(4)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(18)|large_intestine(46)|liver(2)|lung(80)|ovary(12)|pancreas(5)|prostate(1)|skin(50)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(6)	269		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		CTGGAATTCGGAGCGTAATCA	0.383000													6	273					0	0	0.038147	0	0
GLRB	2743	broad.mit.edu	37	4	158041792	158041792	+	Silent	SNP	C	C	T			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr4:158041792C>T	ENST00000264428.4	+	3	477	c.207C>T	c.(205-207)ccC>ccT	p.P69P	GLRB_ENST00000512619.1_Intron|GLRB_ENST00000509282.1_Silent_p.P69P|GLRB_ENST00000541722.1_Silent_p.P69P	NM_000824.4	NP_000815.1	P48167	GLRB_HUMAN	glycine receptor, beta	69					nervous system development|neuropeptide signaling pathway|startle response	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	extracellular-glycine-gated chloride channel activity|protein binding|receptor activity			central_nervous_system(1)|endometrium(3)|large_intestine(11)|lung(6)|skin(5)|upper_aerodigestive_tract(1)	27	all_hematologic(180;0.24)	Renal(120;0.0458)		KIRC - Kidney renal clear cell carcinoma(143;0.0564)|COAD - Colon adenocarcinoma(41;0.0642)|Kidney(143;0.0707)	Glycine(DB00145)	GTTATGATCCCAGGATAAGAC	0.353000													8	82					0	0	0.058154	0	0
FCRL2	79368	broad.mit.edu	37	1	157738454	157738454	+	Silent	SNP	G	G	C			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr1:157738454G>C	ENST00000361516.3	-	5	681	c.633C>G	c.(631-633)gcC>gcG	p.A211A	FCRL2_ENST00000392274.3_Silent_p.A211A|FCRL2_ENST00000368181.4_Intron	NM_030764.3	NP_110391.2	Q96LA5	FCRL2_HUMAN	Fc receptor-like 2	211	Ig-like C2-type 3.				cell-cell signaling	integral to membrane|plasma membrane|soluble fraction	receptor activity|SH3/SH2 adaptor activity			central_nervous_system(2)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(29)|ovary(1)|pancreas(1)|prostate(3)|skin(2)	51	all_hematologic(112;0.0378)		LUSC - Lung squamous cell carcinoma(543;0.24)			GTCCCCCGGGGGCCCGGATCT	0.517000													12	179					0	0	0.119110	0	0
GUF1	60558	broad.mit.edu	37	4	44688028	44688028	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr4:44688028A>G	ENST00000281543.5	+	7	916	c.722A>G	c.(721-723)gAa>gGa	p.E241G	GUF1_ENST00000506793.1_3'UTR	NM_021927.2	NP_068746.2	Q8N442	GUF1_HUMAN	GUF1 GTPase homolog (S. cerevisiae)	241					translation	mitochondrial inner membrane	GTP binding|GTPase activity			breast(1)|cervix(1)|endometrium(1)|large_intestine(3)|lung(8)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	19						GCAATTATTGAAAGAATCCCC	0.313000													8	89					0	0	0.069234	0	0
MIR890	100126303	broad.mit.edu	37	X	145075792	145075792	+	RNA	SNP	G	G	T			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chrX:145075792G>T	ENST00000401256.1	-	0	77					NR_030589.1																						CTTGTACTTGGTAAGACTTAC	0.478000													12	241					1.3612e-06	2.16757e-06	0.132662	1	0
FLG	2312	broad.mit.edu	37	1	152281970	152281970	+	Silent	SNP	G	G	T	rs149105551	byFrequency	TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr1:152281970G>T	ENST00000368799.1	-	3	5427	c.5392C>A	c.(5392-5394)Cga>Aga	p.R1798R	FLG-AS1_ENST00000593011.1_RNA|FLG-AS1_ENST00000420707.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	1798	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GAGCTGTCTCGTGCCTGCTCG	0.597000									Ichthyosis				26	183					7.38237e-10	1.29523e-09	0.116897	1	0
F8	2157	broad.mit.edu	37	X	154157832	154157832	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chrX:154157832C>A	ENST00000360256.4	-	14	4433	c.4233G>T	c.(4231-4233)aaG>aaT	p.K1411N		NM_000132.3	NP_000123.1	P00451	FA8_HUMAN	coagulation factor VIII, procoagulant component	1411	B.				acute-phase response|blood coagulation, intrinsic pathway|cell adhesion|platelet activation|platelet degranulation	extracellular space|plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity|protein binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(27)|liver(1)|lung(47)|ovary(5)|pancreas(3)|prostate(1)|skin(5)|upper_aerodigestive_tract(5)|urinary_tract(2)	120	all_cancers(53;7.19e-17)|all_epithelial(53;9.83e-11)|all_lung(58;6.63e-07)|Lung NSC(58;2.08e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)				Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Drotrecogin alfa(DB00055)	ATGATGATACCTTTGCAATGG	0.413000													11	152					3.07112e-06	4.73599e-06	0.080935	1	0
ARHGEF12	23365	broad.mit.edu	37	11	120349087	120349087	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr11:120349087C>A	ENST00000397843.2	+	37	3921	c.3755C>A	c.(3754-3756)gCa>gAa	p.A1252E	ARHGEF12_ENST00000356641.3_Missense_Mutation_p.A1233E|ARHGEF12_ENST00000532993.1_Missense_Mutation_p.A1149E	NM_015313.2	NP_056128.1	Q9NZN5	ARHGC_HUMAN	Rho guanine nucleotide exchange factor (GEF) 12	1252					apoptosis|axon guidance|G-protein coupled receptor protein signaling pathway|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|membrane	G-protein-coupled receptor binding|GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			NS(1)|breast(5)|endometrium(6)|kidney(5)|large_intestine(13)|lung(23)|ovary(4)|pancreas(1)|prostate(1)|skin(2)	61		Breast(109;0.000813)|Medulloblastoma(222;0.0425)|Hepatocellular(160;0.0831)|all_hematologic(192;0.107)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.231)		GCATTGGATGCACTAAGAAAT	0.388000			T	MLL	AML								3	51					0.115264	0.125548	0.115264	1	0
TRIM15	89870	broad.mit.edu	37	6	30131594	30131594	+	Nonsense_Mutation	SNP	C	C	T			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr6:30131594C>T	ENST00000376694.4	+	1	602	c.133C>T	c.(133-135)Cag>Tag	p.Q45*	TRIM15_ENST00000376688.1_Nonsense_Mutation_p.Q45*	NM_033229.2	NP_150232.2	Q9C019	TRI15_HUMAN	tripartite motif containing 15	45					mesodermal cell fate determination	intracellular	zinc ion binding			large_intestine(2)|lung(8)|prostate(2)|skin(1)|urinary_tract(1)	14						CGCGCTCTCCCAGATGGGGGC	0.682000													3	34					0	0	0.014758	0	0
TAS2R42	353164	broad.mit.edu	37	12	11338720	11338720	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr12:11338720G>T	ENST00000334266.1	-	1	823	c.824C>A	c.(823-825)gCc>gAc	p.A275D		NM_181429.1	NP_852094.1	Q7RTR8	T2R42_HUMAN	taste receptor, type 2, member 42	275					sensory perception of taste	integral to membrane	G-protein coupled receptor activity			breast(1)|kidney(2)|lung(4)|ovary(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	11			OV - Ovarian serous cystadenocarcinoma(49;0.0455)			CGAGGGAAAGGCATTTAAGGC	0.393000													6	75					0.0215528	0.0244766	0.021553	1	0
ELTD1	64123	broad.mit.edu	37	1	79403637	79403637	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr1:79403637A>T	ENST00000370742.3	-	6	678	c.615T>A	c.(613-615)gaT>gaA	p.D205E		NM_022159.3	NP_071442.2	Q9HBW9	ELTD1_HUMAN	EGF, latrophilin and seven transmembrane domain containing 1	205					neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(1)|breast(1)|endometrium(3)|kidney(2)|large_intestine(10)|lung(45)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	69				COAD - Colon adenocarcinoma(225;0.0905)|Colorectal(170;0.103)|all cancers(265;0.105)|Epithelial(280;0.148)		CTACAAATGTATCCCTTTGAA	0.328000													6	77					0	0	0.029380	0	0
FCAR	2204	broad.mit.edu	37	19	55396733	55396733	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr19:55396733C>A	ENST00000355524.3	+	3	167	c.157C>A	c.(157-159)Cgt>Agt	p.R53S	FCAR_ENST00000391724.3_Missense_Mutation_p.R41S|FCAR_ENST00000469767.1_Missense_Mutation_p.R53S|FCAR_ENST00000391726.3_Missense_Mutation_p.R41S|FCAR_ENST00000345937.4_Missense_Mutation_p.R53S|FCAR_ENST00000391723.3_Missense_Mutation_p.R41S|FCAR_ENST00000391725.3_Missense_Mutation_p.R53S|FCAR_ENST00000359272.4_Missense_Mutation_p.R41S|FCAR_ENST00000482092.2_3'UTR|FCAR_ENST00000353758.4_Intron	NM_002000.2	NP_001991.1	P24071	FCAR_HUMAN	Fc fragment of IgA, receptor for	53	Ig-like C2-type 1.				immune response	extracellular region|integral to plasma membrane	IgA binding|receptor activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(14)|ovary(1)|skin(2)	24				GBM - Glioblastoma multiforme(193;0.0443)		CCAGGCCATTCGTGAAGCTTA	0.463000													7	36					1.12685e-05	1.70189e-05	0.047766	1	0
IGKV2D-29	28882	broad.mit.edu	37	2	89986364	89986364	+	RNA	SNP	G	G	A			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr2:89986364G>A	ENST00000491977.1	+	0	43																											GAGGCTCCCTGCTCAGCTCCT	0.567000													6	63					0	0	0.047766	0	0
LPP	4026	broad.mit.edu	37	3	188327400	188327400	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr3:188327400G>A	ENST00000312675.4	+	6	1127	c.881G>A	c.(880-882)gGa>gAa	p.G294E	LPP_ENST00000543006.1_Missense_Mutation_p.G294E|LPP_ENST00000448637.1_Missense_Mutation_p.G294E|LPP_ENST00000471917.1_3'UTR	NM_001167672.1|NM_005578.3	NP_001161144.1|NP_005569.1	Q93052	LPP_HUMAN	LIM domain containing preferred translocation partner in lipoma	294	Pro-rich.				cell adhesion	cytoplasm|focal adhesion|nucleus	protein binding|zinc ion binding		HMGA2/LPP(161)	NS(1)|breast(1)|large_intestine(3)|lung(2)|ovary(1)|upper_aerodigestive_tract(2)	10	all_cancers(143;1.37e-09)|all_hematologic(3;0.0429)|Ovarian(172;0.088)	all_lung(153;0.00139)|Lung NSC(153;0.00202)		GBM - Glioblastoma multiforme(93;0.00602)		CCCAACCAGGGACGCTATTAT	0.547000			T	"""HMGA2, MLL, C12orf9"""	"""lipoma, leukemia"""								12	69					0	0	0.080935	0	0
ASXL2	55252	broad.mit.edu	37	2	26022258	26022258	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr2:26022258C>G	ENST00000435504.4	-	5	692	c.399G>C	c.(397-399)agG>agC	p.R133S	ASXL2_ENST00000497092.1_5'UTR|ASXL2_ENST00000272341.4_5'UTR|ASXL2_ENST00000336112.4_Missense_Mutation_p.R105S			Q76L83	ASXL2_HUMAN	additional sex combs like 2 (Drosophila)	133	Ser-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|protein binding			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(7)|pancreas(1)|prostate(4)|skin(3)|urinary_tract(3)	33	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					ATTTACCTTTCCTTTTCCACC	0.463000													6	170					0	0	0.029380	0	0
CCNB3	85417	broad.mit.edu	37	X	50053799	50053799	+	Missense_Mutation	SNP	A	A	C			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chrX:50053799A>C	ENST00000376042.1	+	6	2928	c.2630A>C	c.(2629-2631)cAc>cCc	p.H877P	CCNB3_ENST00000348603.2_Intron|CCNB3_ENST00000376038.1_Intron|CCNB3_ENST00000276014.7_Missense_Mutation_p.H877P			Q8WWL7	CCNB3_HUMAN	cyclin B3	877					cell division|meiosis|regulation of cyclin-dependent protein kinase activity|regulation of G2/M transition of mitotic cell cycle	nucleus	protein kinase binding			breast(3)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(9)|lung(41)|ovary(4)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	75	Ovarian(276;0.236)					TTTAAGCGACACTCAGCTTTG	0.517000													4	41					0	0	0.014758	0	0
SESN2	83667	broad.mit.edu	37	1	28599220	28599220	+	Silent	SNP	A	A	T			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr1:28599220A>T	ENST00000253063.3	+	5	987	c.666A>T	c.(664-666)gcA>gcT	p.A222A		NM_031459.4	NP_113647.1	P58004	SESN2_HUMAN	sestrin 2	222					cell cycle arrest	cytoplasm|nucleus				cervix(1)|endometrium(3)|large_intestine(5)|lung(7)|ovary(2)|pancreas(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	27		Colorectal(325;3.46e-05)|Lung NSC(340;4.37e-05)|all_lung(284;4.76e-05)|Renal(390;0.00121)|Breast(348;0.00345)|all_neural(195;0.0208)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0261)		OV - Ovarian serous cystadenocarcinoma(117;2.98e-22)|Colorectal(126;3.04e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.00279)|STAD - Stomach adenocarcinoma(196;0.00303)|BRCA - Breast invasive adenocarcinoma(304;0.00595)|READ - Rectum adenocarcinoma(331;0.0649)		AGGGGGATGCAGATGGCAGCC	0.642000													3	36					0	0	0.115264	0	0
LRP2	4036	broad.mit.edu	37	2	170063225	170063225	+	Silent	SNP	G	G	T			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr2:170063225G>T	ENST00000263816.3	-	39	7290	c.7005C>A	c.(7003-7005)ccC>ccA	p.P2335P		NM_004525.2	NP_004516.2	P98164	LRP2_HUMAN	low density lipoprotein receptor-related protein 2	2335					hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			biliary_tract(1)|breast(16)|central_nervous_system(6)|cervix(2)|endometrium(24)|haematopoietic_and_lymphoid_tissue(2)|kidney(17)|large_intestine(70)|liver(1)|lung(117)|ovary(19)|pancreas(1)|prostate(2)|skin(17)|upper_aerodigestive_tract(7)|urinary_tract(13)	315				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	CTGGTGACCGGGGCTGGACTT	0.502000													5	54					2.0095e-06	3.13182e-06	0.029380	1	0
CRYGS	1427	broad.mit.edu	37	3	186256671	186256671	+	Silent	SNP	G	G	A			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr3:186256671G>A	ENST00000392499.2	-	4	690	c.351C>T	c.(349-351)tcC>tcT	p.S117S	CRYGS_ENST00000307944.5_Silent_p.S117S	NM_017541.2	NP_060011.1	P22914	CRBS_HUMAN	crystallin, gamma S	117	Beta/gamma crystallin 'Greek key' 3.						structural constituent of eye lens			endometrium(1)|kidney(2)|large_intestine(2)|lung(3)|prostate(1)|upper_aerodigestive_tract(2)	11	all_cancers(143;3.75e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;5.5e-22)	GBM - Glioblastoma multiforme(93;0.0906)		GCTCCATGATGGAAGGGCAAT	0.478000													10	72					0	0	0.069234	0	0
CRB1	23418	broad.mit.edu	37	1	197404113	197404113	+	Silent	SNP	C	C	A			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr1:197404113C>A	ENST00000367397.1	+	5	2121	c.1263C>A	c.(1261-1263)tcC>tcA	p.S421S	CRB1_ENST00000367400.3_Silent_p.S1040S|CRB1_ENST00000367399.2_Silent_p.S928S|CRB1_ENST00000535699.1_Silent_p.S1016S|CRB1_ENST00000538660.1_Intron|CRB1_ENST00000544212.1_Silent_p.S521S			P82279	CRUM1_HUMAN	crumbs homolog 1 (Drosophila)	1040	EGF-like 10; calcium-binding (Potential).				cell-cell signaling|establishment or maintenance of cell polarity	apical plasma membrane|extracellular region|integral to membrane	calcium ion binding|protein binding			NS(1)|breast(4)|central_nervous_system(2)|cervix(3)|endometrium(13)|kidney(4)|large_intestine(21)|lung(58)|ovary(7)|prostate(3)|skin(10)|upper_aerodigestive_tract(4)|urinary_tract(2)	132						TGACCCTTTCCATGACAGACC	0.453000													7	112					0.000157383	0.000218546	0.038147	1	0
KIF26B	55083	broad.mit.edu	37	1	245848849	245848849	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr1:245848849C>A	ENST00000366518.4	+	9	1525	c.1421C>A	c.(1420-1422)tCc>tAc	p.S474Y	KIF26B_ENST00000407071.2_Missense_Mutation_p.S855Y			Q2KJY2	KI26B_HUMAN	kinesin family member 26B	855	Kinesin-motor.				microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(21)|ovary(4)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	51	all_cancers(71;3.86e-05)|all_epithelial(71;0.000121)|Ovarian(71;0.0412)|all_lung(81;0.0498)|Lung NSC(105;0.0708)|Breast(184;0.127)		OV - Ovarian serous cystadenocarcinoma(106;0.022)			CCCGACTACTCCTCCAGCAGC	0.672000													4	12					0.00024832	0.000335289	0.009096	1	0
AHNAK2	113146	broad.mit.edu	37	14	105412292	105412292	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr14:105412292C>A	ENST00000333244.5	-	7	9615	c.9496G>T	c.(9496-9498)Gtg>Ttg	p.V3166L	AHNAK2_ENST00000557457.1_Intron	NM_138420.2	NP_612429.2	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	3166						nucleus				cervix(4)|endometrium(4)|large_intestine(3)|lung(14)|ovary(2)|prostate(2)|skin(1)|stomach(3)	33		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			GACACATCCACCAAGACCTCA	0.577000													5	88					8.12818e-05	0.000116174	0.029380	1	0
TLR4	7099	broad.mit.edu	37	9	120466837	120466837	+	Nonsense_Mutation	SNP	C	C	A			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr9:120466837C>A	ENST00000355622.6	+	1	188	c.87C>A	c.(85-87)tgC>tgA	p.C29*	TLR4_ENST00000472304.1_3'UTR|TLR4_ENST00000394487.4_De_novo_Start_InFrame	NM_138554.4|NM_138557.2	NP_612564.1|NP_612567.1	O00206	TLR4_HUMAN	toll-like receptor 4	29					activation of MAPK activity|cellular response to mechanical stimulus|detection of fungus|detection of lipopolysaccharide|I-kappaB phosphorylation|innate immune response|intestinal epithelial structure maintenance|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of ERK1 and ERK2 cascade|negative regulation of interferon-gamma production|negative regulation of interleukin-17 production|negative regulation of interleukin-23 production|negative regulation of interleukin-6 production|negative regulation of osteoclast differentiation|negative regulation of tumor necrosis factor production|positive regulation of chemokine production|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of interferon-gamma production|positive regulation of interleukin-1 production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 biosynthetic process|positive regulation of interleukin-12 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 biosynthetic process|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of platelet activation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor biosynthetic process|positive regulation of tumor necrosis factor production|T-helper 1 type immune response|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	external side of plasma membrane|integral to plasma membrane|lipopolysaccharide receptor complex|perinuclear region of cytoplasm	lipopolysaccharide receptor activity|transmembrane receptor activity			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(12)|lung(66)|ovary(4)|pancreas(1)|skin(6)|upper_aerodigestive_tract(5)|urinary_tract(1)	103						GGGAGCCCTGCGTGGAGGTAT	0.542000													4	72					0.00024832	0.000335289	0.009096	1	0
ACSM2A	123876	broad.mit.edu	37	16	20482505	20482505	+	Nonsense_Mutation	SNP	C	C	A	rs142316126		TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr16:20482505C>A	ENST00000573854.1	+	5	821	c.707C>A	c.(706-708)tCg>tAg	p.S236*	ACSM2A_ENST00000575690.1_Nonsense_Mutation_p.S236*|ACSM2A_ENST00000575558.1_3'UTR|ACSM2A_ENST00000417235.2_Nonsense_Mutation_p.S157*|ACSM2A_ENST00000536134.1_Intron|ACSM2A_ENST00000219054.6_Nonsense_Mutation_p.S236*|ACSM2A_ENST00000396104.2_Nonsense_Mutation_p.S236*	NM_001010845.2	NP_001010845.1	Q08AH3	ACS2A_HUMAN	acyl-CoA synthetase medium-chain family member 2A	236					fatty acid metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|metal ion binding			breast(2)|central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(3)|lung(34)|ovary(1)|skin(6)|stomach(1)	51						CATTCCTACTCGAGCCTGGGC	0.502000													14	116					6.94344e-10	1.22556e-09	0.038395	1	0
LYST	1130	broad.mit.edu	37	1	235973558	235973558	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr1:235973558A>G	ENST00000389794.3	-	5	734	c.560T>C	c.(559-561)cTg>cCg	p.L187P	LYST_ENST00000389793.2_Missense_Mutation_p.L187P|LYST_ENST00000536965.1_Missense_Mutation_p.L187P			Q99698	LYST_HUMAN	lysosomal trafficking regulator	187					defense response to bacterium|defense response to protozoan|defense response to virus|endosome to lysosome transport via multivesicular body sorting pathway|leukocyte chemotaxis|mast cell secretory granule organization|melanosome organization|natural killer cell mediated cytotoxicity|protein transport	cytoplasm|microtubule cytoskeleton	protein binding			NS(1)|breast(13)|central_nervous_system(3)|cervix(3)|endometrium(17)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(27)|lung(66)|ovary(7)|pancreas(1)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	162	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.00246)|Prostate(94;0.0771)|Acute lymphoblastic leukemia(190;0.228)	OV - Ovarian serous cystadenocarcinoma(106;0.000674)			ATGATGCAGCAGATGGGGCCT	0.433000													11	135					0	0	0.093190	0	0
ANK2	287	broad.mit.edu	37	4	114294269	114294269	+	Silent	SNP	C	C	A			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr4:114294269C>A	ENST00000357077.4	+	44	11687	c.11634C>A	c.(11632-11634)ccC>ccA	p.P3878P	ANK2_ENST00000264366.6_Silent_p.P3845P|ANK2_ENST00000394537.3_Silent_p.P1793P|ANK2_ENST00000510275.2_Silent_p.P476P|ANK2_ENST00000509550.1_Silent_p.P969P|ANK2_ENST00000506722.1_Silent_p.P1784P	NM_001148.4	NP_001139.3	Q01484	ANK2_HUMAN	ankyrin 2, neuronal	3845					axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding			NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(10)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(54)|liver(2)|lung(112)|ovary(8)|pancreas(1)|prostate(7)|skin(11)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(10)	248		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		CTGAAATACCCCCAGAAACAG	0.418000													13	183					3.41278e-10	6.09723e-10	0.033300	1	0
C16orf70	80262	broad.mit.edu	37	16	67168097	67168097	+	Silent	SNP	T	T	C			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr16:67168097T>C	ENST00000219139.3	+	7	665	c.477T>C	c.(475-477)tcT>tcC	p.S159S	C16orf70_ENST00000569600.1_Silent_p.S159S|C16orf70_ENST00000569683.1_3'UTR	NM_025187.3	NP_079463.2	Q9BSU1	CP070_HUMAN	chromosome 16 open reading frame 70	159										cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(6)|ovary(3)|skin(1)	17		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0017)|Epithelial(162;0.00655)|all cancers(182;0.0579)		GCCTGGCTTCTCTCCAGATAC	0.483000													4	56					0	0	0.021553	0	0
FLG	2312	broad.mit.edu	37	1	152281902	152281902	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr1:152281902G>T	ENST00000368799.1	-	3	5495	c.5460C>A	c.(5458-5460)agC>agA	p.S1820R	FLG-AS1_ENST00000593011.1_RNA|FLG-AS1_ENST00000420707.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	1820	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TTCCTCCTCTGCTTGACCCTG	0.577000									Ichthyosis				11	279					0.0135373	0.0156776	0.093190	1	0
IGHV1OR16-3	28313	broad.mit.edu	37	16	32070602	32070602	+	RNA	SNP	G	G	C			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr16:32070602G>C	ENST00000566806.1	-	0	499																											CCTCAGTGAAGGTCTCCTGCA	0.572000													7	103					0	0	0.069234	0	0
EP400	57634	broad.mit.edu	37	12	132522304	132522304	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr12:132522304A>T	ENST00000333577.4	+	32	6246	c.6137A>T	c.(6136-6138)cAg>cTg	p.Q2046L	EP400_ENST00000389561.2_Missense_Mutation_p.Q2010L|EP400_ENST00000332482.4_Missense_Mutation_p.Q1973L|EP400_ENST00000389562.2_Missense_Mutation_p.Q2009L|EP400_ENST00000330386.6_Missense_Mutation_p.Q1929L			Q96L91	EP400_HUMAN	E1A binding protein p400	2046	Helicase C-terminal.				histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nuclear speck	ATP binding|DNA binding|helicase activity			NS(1)|breast(6)|central_nervous_system(10)|cervix(1)|endometrium(21)|kidney(13)|large_intestine(25)|lung(56)|ovary(5)|prostate(8)|skin(6)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	161	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.198)		OV - Ovarian serous cystadenocarcinoma(86;3.01e-08)|Epithelial(86;3.43e-07)|all cancers(50;2.01e-06)		GTGGCTGCTCAGGGAAATGAC	0.463000													5	53					0	0	0.029380	0	0
TECRL	253017	broad.mit.edu	37	4	65275158	65275158	+	Translation_Start_Site	SNP	C	C	A			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr4:65275158C>A	ENST00000381210.3	-	0	22				TECRL_ENST00000507440.1_De_novo_Start_InFrame	NM_001010874.4	NP_001010874.2	Q5HYJ1	TECRL_HUMAN	trans-2,3-enoyl-CoA reductase-like						lipid metabolic process	cytoplasm|integral to membrane	oxidoreductase activity, acting on the CH-CH group of donors			endometrium(2)|kidney(5)|large_intestine(7)|lung(30)|prostate(1)|skin(1)|stomach(1)	47						GCTGGAGAACCTTTGAAAGGT	0.368000													3	29					0.004672	0.0056566	0.115264	1	0
KIAA0922	23240	broad.mit.edu	37	4	154524536	154524536	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr4:154524536G>T	ENST00000409663.3	+	24	2770	c.2718G>T	c.(2716-2718)agG>agT	p.R906S	KIAA0922_ENST00000409959.3_Missense_Mutation_p.R907S|KIAA0922_ENST00000440693.1_Missense_Mutation_p.R823S	NM_015196.3	NP_056011.3	A2VDJ0	T131L_HUMAN	KIAA0922	906						integral to membrane				breast(2)|cervix(1)|endometrium(7)|kidney(4)|large_intestine(16)|lung(20)|ovary(1)|prostate(4)|skin(3)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	63	all_hematologic(180;0.093)	Renal(120;0.118)				CAAGACAGAGGCAAAATGCTA	0.423000													7	93					0.000157383	0.000218546	0.038147	1	0
FAM13A	10144	broad.mit.edu	37	4	89912230	89912230	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr4:89912230G>A	ENST00000264344.5	-	4	706	c.499C>T	c.(499-501)Ctc>Ttc	p.L167F	FAM13A_ENST00000515600.1_Missense_Mutation_p.L167F|FAM13A_ENST00000509094.1_Missense_Mutation_p.L167F|FAM13A_ENST00000502459.1_5'UTR|FAM13A_ENST00000511976.1_Intron	NM_014883.3	NP_055698.2	O94988	FA13A_HUMAN	family with sequence similarity 13, member A	167	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			NS(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(11)|liver(1)|lung(22)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	55						TACTTGAGGAGGCAGTAGTGG	0.408000													3	41					0	0	0.115264	0	0
STARD13	90627	broad.mit.edu	37	13	33687050	33687050	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr13:33687050C>G	ENST00000336934.5	-	9	2416	c.2300G>C	c.(2299-2301)cGg>cCg	p.R767P	STARD13_ENST00000255486.4_Missense_Mutation_p.R759P|STARD13_ENST00000399365.3_Missense_Mutation_p.R649P	NM_001243476.1|NM_178006.3	NP_001230405.1|NP_821074.1	Q9Y3M8	STA13_HUMAN	StAR-related lipid transfer (START) domain containing 13	767	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|lipid particle|mitochondrial membrane	GTPase activator activity|protein binding			breast(2)|endometrium(2)|kidney(3)|large_intestine(6)|lung(18)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|soft_tissue(1)|upper_aerodigestive_tract(1)	40	all_epithelial(80;0.155)	Lung SC(185;0.0367)		all cancers(112;1.31e-05)|Epithelial(112;0.000142)|BRCA - Breast invasive adenocarcinoma(63;0.00936)|OV - Ovarian serous cystadenocarcinoma(117;0.0533)|Lung(94;0.143)|GBM - Glioblastoma multiforme(144;0.143)		GGCCTGCAGCCGCTGCTCTTT	0.557000													4	8					0	0	0.047766	0	0
OR2M3	127062	broad.mit.edu	37	1	248367065	248367065	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr1:248367065G>T	ENST00000456743.1	+	1	734	c.696G>T	c.(694-696)gaG>gaT	p.E232D		NM_001004689.1	NP_001004689.1	Q8NG83	OR2M3_HUMAN	olfactory receptor, family 2, subfamily M, member 3	232					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(6)|large_intestine(4)|lung(33)|ovary(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	50	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			GATCTGGAGAGGGTCGTCGCA	0.448000													13	339					3.27435e-08	5.32992e-08	0.119110	1	0
NLRP14	338323	broad.mit.edu	37	11	7067906	7067906	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr11:7067906G>C	ENST00000299481.4	+	5	2312	c.1966G>C	c.(1966-1968)Gat>Cat	p.D656H		NM_176822.3	NP_789792.1	Q86W24	NAL14_HUMAN	NLR family, pyrin domain containing 14	656					cell differentiation|multicellular organismal development|spermatogenesis		ATP binding			breast(3)|large_intestine(7)|lung(1)|ovary(3)|pancreas(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	21				Epithelial(150;4.62e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0871)		AAGGGATGGTGATCGCATTAC	0.378000													11	102					0	0	0.093190	0	0
ABCA8	10351	broad.mit.edu	37	17	66878079	66878079	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr17:66878079C>A	ENST00000269080.2	-	29	3888	c.3751G>T	c.(3751-3753)Ggg>Tgg	p.G1251W	ABCA8_ENST00000586539.1_Missense_Mutation_p.G1291W|ABCA8_ENST00000430352.2_Missense_Mutation_p.G1291W	NM_007168.2	NP_009099.1	O94911	ABCA8_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 8	1251	ABC transporter 2.					integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(3)|central_nervous_system(2)|endometrium(9)|kidney(5)|large_intestine(19)|liver(1)|lung(30)|ovary(3)|pancreas(2)|prostate(2)|skin(3)|urinary_tract(4)	83	Breast(10;4.56e-13)					TTCCTCTTCCCTGCATACTCC	0.423000													14	107					6.31663e-08	1.02253e-07	0.132662	1	0
IL1RL2	8808	broad.mit.edu	37	2	102828581	102828581	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr2:102828581G>A	ENST00000264257.2	+	6	797	c.671G>A	c.(670-672)gGa>gAa	p.G224E	IL1RL2_ENST00000539491.1_Missense_Mutation_p.G224E|IL1RL2_ENST00000481806.1_3'UTR|IL1RL2_ENST00000441515.2_Missense_Mutation_p.G106E	NM_003854.2	NP_003845.2	Q9HB29	ILRL2_HUMAN	interleukin 1 receptor-like 2	224	Ig-like C2-type 3.				cellular defense response|innate immune response	integral to plasma membrane	interleukin-1, Type I, activating receptor activity			breast(1)|cervix(1)|endometrium(5)|large_intestine(6)|liver(2)|lung(8)|ovary(2)|prostate(1)	26						GGATATGGAGGAAGTGTCCCT	0.363000													4	63					0	0	0.009096	0	0
FAM105A	54491	broad.mit.edu	37	5	14601519	14601519	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr5:14601519G>C	ENST00000274217.3	+	4	436	c.316G>C	c.(316-318)Gga>Cga	p.G106R		NM_019018.2	NP_061891.1	Q9NUU6	F105A_HUMAN	family with sequence similarity 105, member A	106										large_intestine(3)|lung(5)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	11	Lung NSC(4;0.00592)					AGAATGGAAAGGAGAGACACC	0.408000													8	54					0	0	0.038147	0	0
SVEP1	79987	broad.mit.edu	37	9	113231346	113231346	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr9:113231346G>C	ENST00000401783.2	-	17	3370	c.3034C>G	c.(3034-3036)Cat>Gat	p.H1012D	SVEP1_ENST00000374469.1_Missense_Mutation_p.H989D|SVEP1_ENST00000302728.8_Missense_Mutation_p.H1012D|SVEP1_ENST00000467821.1_5'UTR	NM_153366.3	NP_699197.3	Q4LDE5	SVEP1_HUMAN	sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1	1012					cell adhesion	cytoplasm|extracellular region|membrane	calcium ion binding			NS(1)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|cervix(2)|endometrium(19)|kidney(8)|large_intestine(24)|lung(58)|ovary(7)|prostate(7)|skin(1)|stomach(4)|upper_aerodigestive_tract(5)|urinary_tract(4)	147						CAGGTGAAATGTTCCAGATTA	0.433000													7	100					0	0	0.058154	0	0
CARD8	22900	broad.mit.edu	37	19	48733807	48733807	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr19:48733807C>T	ENST00000391898.3	-	7	965	c.923G>A	c.(922-924)gGg>gAg	p.G308E	CARD8_ENST00000519940.1_Missense_Mutation_p.G308E|CARD8_ENST00000359009.4_Missense_Mutation_p.G202E|CARD8_ENST00000357778.5_Missense_Mutation_p.G33E|ZNF114_ENST00000597695.1_Intron|CARD8_ENST00000521613.1_Missense_Mutation_p.G258E|CARD8_ENST00000520015.1_Missense_Mutation_p.G308E|CARD8_ENST00000520753.1_Missense_Mutation_p.G308E|CARD8_ENST00000520153.1_Missense_Mutation_p.G258E|CARD8_ENST00000447740.2_Missense_Mutation_p.G258E	NM_001184900.1	NP_001171829.1	Q9Y2G2	CARD8_HUMAN	caspase recruitment domain family, member 8	202					negative regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-1 beta secretion	cytoplasm|nucleus	caspase activator activity|NACHT domain binding|protein homodimerization activity			endometrium(1)|large_intestine(4)|lung(8)|prostate(1)|skin(1)	15		all_lung(116;0.000112)|Lung NSC(112;0.000192)|all_epithelial(76;0.000349)|all_neural(266;0.0228)|Ovarian(192;0.113)|Prostate(7;0.184)		OV - Ovarian serous cystadenocarcinoma(262;0.000112)|all cancers(93;0.000293)|Epithelial(262;0.0129)|GBM - Glioblastoma multiforme(486;0.0336)		GAGGCGAGTCCCACTGGCGAT	0.572000													5	74					0	0	0.038147	0	0
TTN	7273	broad.mit.edu	37	2	179442618	179442618	+	Silent	SNP	A	A	T			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr2:179442618A>T	ENST00000589042.1	-	323	68759	c.68535T>A	c.(68533-68535)ccT>ccA	p.P22845P	TTN-AS1_ENST00000586831.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000590932.1_RNA|TTN_ENST00000359218.5_Silent_p.P13905P|TTN_ENST00000342175.6_Silent_p.P13972P|TTN-AS1_ENST00000586707.1_RNA|TTN-AS1_ENST00000456053.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN_ENST00000460472.2_Silent_p.P13780P|TTN_ENST00000342992.6_Silent_p.P20277P|TTN-AS1_ENST00000591332.1_RNA|TTN_ENST00000591111.1_Silent_p.P21204P|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000592600.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000438095.1_RNA|TTN-AS1_ENST00000592750.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	21204	Ig-like 117.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CAGGTTTTCCAGGAGGATCTA	0.348000													5	53					0	0	0.014758	0	0
AMER1	139285	broad.mit.edu	37	X	63411301	63411301	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chrX:63411301C>A	ENST00000330258.3	-	2	2138	c.1866G>T	c.(1864-1866)gaG>gaT	p.E622D	AMER1_ENST00000403336.1_Missense_Mutation_p.E622D|AMER1_ENST00000374869.3_Missense_Mutation_p.E622D	NM_152424.3	NP_689637.3			APC membrane recruitment protein 1									p.0?(67)									GGGTTCTGGCCTCCCTGCCAT	0.617000													3	29					5.18039e-06	7.90549e-06	0.038147	1	0
MED12L	116931	broad.mit.edu	37	3	151082975	151082975	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr3:151082975G>T	ENST00000474524.1	+	20	3099	c.3061G>T	c.(3061-3063)Ggc>Tgc	p.G1021C	MED12L_ENST00000273432.4_Missense_Mutation_p.G881C|P2RY12_ENST00000302632.3_Intron	NM_053002.4	NP_443728.3	Q86YW9	MD12L_HUMAN	mediator complex subunit 12-like	1021					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	mediator complex				NS(1)|breast(3)|central_nervous_system(3)|cervix(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(27)|lung(50)|ovary(6)|prostate(3)|skin(4)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	128			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			TGTATGTATGGGCCATCAGGA	0.463000													5	156					0.000602214	0.000794815	0.014758	1	0
IGHV3-33	28434	broad.mit.edu	37	14	106815883	106815883	+	RNA	SNP	G	G	A			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr14:106815883G>A	ENST00000390615.2	-	0	269																											ACCCACTCCAGCCCCTTGCCT	0.542000													8	99					0	0	0.105934	0	0
IGKV3-11	28914	broad.mit.edu	37	2	89326735	89326735	+	RNA	SNP	A	A	T			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr2:89326735A>T	ENST00000483158.1	-	0	324																											GCTGATGGTGAGAGTGAAGTC	0.542000													6	105					0	0	0.038147	0	0
LILRA1	11024	broad.mit.edu	37	19	55107290	55107290	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr19:55107290C>A	ENST00000251372.3	+	6	1030	c.848C>A	c.(847-849)aCc>aAc	p.T283N	LILRB1_ENST00000418536.2_Intron|LILRA1_ENST00000473156.1_3'UTR|LILRA1_ENST00000453777.1_Intron|LILRB1_ENST00000448689.1_Intron|LILRB1_ENST00000396321.2_Intron	NM_006863.1	NP_006854.1	O75019	LIRA1_HUMAN	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1	283	Ig-like C2-type 3.				cell surface receptor linked signaling pathway|defense response|regulation of immune response	integral to membrane|plasma membrane	antigen binding|transmembrane receptor activity			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(5)|liver(1)|lung(23)|ovary(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)	47				GBM - Glioblastoma multiforme(193;0.0348)		GCCAACTTCACCCTGGGCCCT	0.632000													3	27					0.115264	0.125548	0.115264	1	0
LETMD1	25875	broad.mit.edu	37	12	51442961	51442961	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr12:51442961C>A	ENST00000418425.2	+	2	286	c.267C>A	c.(265-267)ttC>ttA	p.F89L	LETMD1_ENST00000548516.1_3'UTR|LETMD1_ENST00000552739.1_Intron|LETMD1_ENST00000550929.1_Missense_Mutation_p.F33L|LETMD1_ENST00000262055.4_Missense_Mutation_p.F89L|LETMD1_ENST00000547008.1_Missense_Mutation_p.F89L|LETMD1_ENST00000380123.2_Missense_Mutation_p.F89L	NM_001243689.1	NP_001230618.1	Q6P1Q0	LTMD1_HUMAN	LETM1 domain containing 1	89	LETM1.|Required and sufficient for mitochondrial import.					integral to membrane|mitochondrial outer membrane	protein binding			central_nervous_system(2)|endometrium(1)|kidney(3)|large_intestine(2)|lung(4)|skin(1)|urinary_tract(3)	16						ACACAATCTTCATGAAAGGTA	0.403000													3	41					0.115264	0.125548	0.115264	1	0
TSHZ3	57616	broad.mit.edu	37	19	31768661	31768661	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr19:31768661C>T	ENST00000240587.4	-	2	2365	c.2038G>A	c.(2038-2040)Gat>Aat	p.D680N		NM_020856.2	NP_065907.2	Q63HK5	TSH3_HUMAN	teashirt zinc finger homeobox 3	680					negative regulation of transcription, DNA-dependent|regulation of respiratory gaseous exchange by neurological system process	growth cone|nucleus	chromatin binding|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(4)|endometrium(15)|kidney(9)|large_intestine(20)|lung(60)|ovary(4)|pancreas(2)|prostate(4)|skin(5)	123	Esophageal squamous(110;0.226)					GGGCTCCCATCCTTGCACCCA	0.652000													4	46					0	0	0.014758	0	0
CMTR2	55783	broad.mit.edu	37	16	71318874	71318874	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr16:71318874C>T	ENST00000338099.5	-	3	1286	c.950G>A	c.(949-951)tGc>tAc	p.C317Y	FTSJD1_ENST00000434935.2_Missense_Mutation_p.C317Y			Q8IYT2	FTSJ1_HUMAN		317				C -> S (in Ref. 5; AAM49718).		integral to membrane	methyltransferase activity|nucleic acid binding			breast(1)|endometrium(2)|kidney(3)|large_intestine(6)|lung(12)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	27						ATAGTGGAGGCAAACCACATA	0.428000													9	76					0	0	0.047766	0	0
LCT	3938	broad.mit.edu	37	2	136561575	136561575	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr2:136561575C>T	ENST00000264162.2	-	11	4598	c.4588G>A	c.(4588-4590)Gtg>Atg	p.V1530M		NM_002299.2	NP_002290.2	P09848	LPH_HUMAN	lactase	1530	4 X approximate repeats.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|integral to plasma membrane|membrane fraction	cation binding|glycosylceramidase activity|lactase activity			breast(6)|central_nervous_system(3)|cervix(1)|endometrium(8)|kidney(2)|large_intestine(26)|lung(57)|ovary(7)|pancreas(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(4)	124				BRCA - Breast invasive adenocarcinoma(221;0.169)		CAAAACTTCACCTTGTCTCCC	0.537000													3	40					0	0	0.014758	0	0
EPHB1	2047	broad.mit.edu	37	3	134967157	134967157	+	Splice_Site	SNP	G	G	T			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr3:134967157G>T	ENST00000398015.3	+	14	2866		c.e14-1		EPHB1_ENST00000493838.1_Splice_Site	NM_004441.4	NP_004432.1	P54762	EPHB1_HUMAN	EPH receptor B1							integral to plasma membrane	ATP binding|ephrin receptor activity|protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(13)|lung(63)|ovary(8)|pancreas(2)|prostate(8)|skin(7)|stomach(4)|upper_aerodigestive_tract(4)|urinary_tract(2)	130						TGTCACTGCAGGTCATCAATG	0.557000													3	33					6.4e-05	9.28521e-05	0.115264	1	0
THEMIS	387357	broad.mit.edu	37	6	128151040	128151040	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr6:128151040G>A	ENST00000368250.1	-	4	551	c.53C>T	c.(52-54)aCt>aTt	p.T18I	THEMIS_ENST00000543064.1_Missense_Mutation_p.T97I|THEMIS_ENST00000537166.1_Missense_Mutation_p.T62I|THEMIS_ENST00000368248.2_Missense_Mutation_p.T97I			Q8N1K5	THMS1_HUMAN	thymocyte selection associated	97	CABIT 1.				negative T cell selection|positive T cell selection|T cell receptor signaling pathway	cytoplasm|nucleus				breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|liver(1)|lung(28)|ovary(2)|pancreas(1)|prostate(1)|skin(4)|stomach(1)|urinary_tract(3)	60						TTCTTCCATAGTAAGGTATGG	0.348000													3	42					0	0	0.009096	0	0
DAB1	1600	broad.mit.edu	37	1	57476947	57476947	+	Splice_Site	SNP	T	T	A			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr1:57476947T>A	ENST00000371236.2	-	13	1708		c.e13-2		DAB1_ENST00000371231.1_Splice_Site|DAB1_ENST00000439789.2_Splice_Site|DAB1_ENST00000420954.2_Splice_Site|DAB1_ENST00000485760.1_Splice_Site|DAB1_ENST00000371234.4_Splice_Site|DAB1_ENST00000414851.2_Splice_Site			O75553	DAB1_HUMAN	Dab, reelin signal transducer, homolog 1 (Drosophila)						cell differentiation|nervous system development					central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(28)|ovary(3)|skin(4)|upper_aerodigestive_tract(5)|urinary_tract(5)	64						GGGTTGGAGCTACACAGAGAC	0.453000													11	81					0	0	0.080935	0	0
ZNF716	441234	broad.mit.edu	37	7	57529296	57529296	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr7:57529296G>C	ENST00000420713.1	+	4	1241	c.1129G>C	c.(1129-1131)Gag>Cag	p.E377Q		NM_001159279.1	NP_001152751.1			zinc finger protein 716											breast(1)|kidney(1)|lung(20)|ovary(2)	24						TCATACTGGAGAGAAACCCTA	0.418000													3	36					0	0	0.115264	0	0
RIOK1	83732	broad.mit.edu	37	6	7396953	7396953	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr6:7396953G>T	ENST00000379834.2	+	4	892	c.385G>T	c.(385-387)Gat>Tat	p.D129Y		NM_031480.2|NM_153005.1	NP_113668.2|NP_694550.1	Q9BRS2	RIOK1_HUMAN	RIO kinase 1	129							ATP binding|protein serine/threonine kinase activity			cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(6)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	19	Ovarian(93;0.0418)					AAATGTTACTGATTCCGTCAT	0.328000													9	104					3.09899e-07	4.98903e-07	0.047766	1	0
SETD2	29072	broad.mit.edu	37	3	47098912	47098912	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr3:47098912C>A	ENST00000409792.3	-	15	6404	c.6362G>T	c.(6361-6363)cGc>cTc	p.R2121L		NM_014159.6	NP_054878.5	Q9BYW2	SETD2_HUMAN	SET domain containing 2	2121					regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	DNA binding|histone-lysine N-methyltransferase activity|oxidoreductase activity|transition metal ion binding			breast(6)|central_nervous_system(5)|endometrium(4)|kidney(63)|large_intestine(18)|lung(26)|ovary(6)|prostate(2)|skin(3)|soft_tissue(1)|stomach(2)|urinary_tract(5)	141		Acute lymphoblastic leukemia(5;0.0169)		BRCA - Breast invasive adenocarcinoma(193;0.000302)|KIRC - Kidney renal clear cell carcinoma(197;0.00732)|Kidney(197;0.00844)		CAACTTCCGGCGTTCCTCTGT	0.428000			"""N, F, S, Mis"""		clear cell renal carcinoma								6	66					8.12818e-05	0.000116174	0.029380	1	0
PGK1	5230	broad.mit.edu	37	X	77378447	77378447	+	Splice_Site	SNP	G	G	T			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chrX:77378447G>T	ENST00000373316.4	+	7	923		c.e7+1		PGK1_ENST00000442431.1_Splice_Site|PGK1_ENST00000537456.1_Splice_Site	NM_000291.3	NP_000282.1	P00558	PGK1_HUMAN	phosphoglycerate kinase 1						gluconeogenesis|glycolysis	cytosol	ATP binding|phosphoglycerate kinase activity			breast(1)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(5)|lung(10)|ovary(1)|upper_aerodigestive_tract(1)	24						CAACATGGAGGTAGGAAACAA	0.383000													17	100					1.67942e-08	2.78005e-08	0.038395	1	0
YEATS2	55689	broad.mit.edu	37	3	183446632	183446632	+	Nonsense_Mutation	SNP	G	G	T			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr3:183446632G>T	ENST00000305135.5	+	7	1000	c.805G>T	c.(805-807)Gaa>Taa	p.E269*		NM_018023.4	NP_060493.3	Q9ULM3	YETS2_HUMAN	YEATS domain containing 2	269	YEATS.				histone H3 acetylation|negative regulation of transcription from RNA polymerase II promoter	Ada2/Gcn5/Ada3 transcription activator complex	TBP-class protein binding			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(24)|ovary(3)|prostate(2)|skin(3)	49	all_cancers(143;6.55e-10)|Ovarian(172;0.0303)		all cancers(12;2.38e-42)|Epithelial(37;1.9e-36)|OV - Ovarian serous cystadenocarcinoma(80;6.48e-22)			TGACCTTGTGGAAGTTAGGTA	0.378000													5	52					0.00116845	0.00148205	0.021553	1	0
UGT2B4	7363	broad.mit.edu	37	4	70346367	70346367	+	Silent	SNP	C	C	T			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr4:70346367C>T	ENST00000305107.6	-	6	1618	c.1572G>A	c.(1570-1572)aaG>aaA	p.K524K	UGT2B4_ENST00000512583.1_3'UTR|UGT2B4_ENST00000506580.1_5'UTR|UGT2B4_ENST00000381096.3_Silent_p.K388K	NM_021139.2	NP_066962.2	P06133	UD2B4_HUMAN	UDP glucuronosyltransferase 2 family, polypeptide B4	524					estrogen catabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(29)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	47						CTCTTTTCCCCTTCTTTCCTG	0.408000													4	67					0	0	0.009096	0	0
ZNF107	51427	broad.mit.edu	37	7	64167568	64167568	+	Nonsense_Mutation	SNP	G	G	T			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr7:64167568G>T	ENST00000395391.1	+	4	2261	c.886G>T	c.(886-888)Gga>Tga	p.G296*	ZNF107_ENST00000344930.3_Nonsense_Mutation_p.G296*|ZNF107_ENST00000423627.1_Nonsense_Mutation_p.G296*			Q9UII5	ZN107_HUMAN	zinc finger protein 107	296					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(18)|ovary(1)|stomach(1)	37		Lung NSC(55;0.00948)|all_lung(88;0.0249)				AATTCATACTGGAGGGAAACT	0.353000													6	70					0.0215528	0.0244766	0.021553	1	0
TUBB8P7	197331	broad.mit.edu	37	16	90161556	90161556	+	RNA	SNP	G	G	A			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr16:90161556G>A	ENST00000564451.1	+	0	909				TUBB8P7_ENST00000567960.1_RNA																							GTGTGGGGCCGGAAACAACTG	0.567000													5	17					0	0	0.014758	0	0
ABCB11	8647	broad.mit.edu	37	2	169850327	169850327	+	Nonsense_Mutation	SNP	G	G	T			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr2:169850327G>T	ENST00000263817.6	-	8	801	c.677C>A	c.(676-678)tCg>tAg	p.S226*		NM_003742.2	NP_003733.2	O95342	ABCBB_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 11	226	ABC transmembrane type-1 1.				bile acid biosynthetic process	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus|membrane fraction	ATP binding|bile acid-exporting ATPase activity|canalicular bile acid transmembrane transporter activity|sodium-exporting ATPase activity, phosphorylative mechanism			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(16)|lung(26)|ovary(3)|stomach(1)	57					Adenosine triphosphate(DB00171)|Bosentan(DB00559)|Glibenclamide(DB01016)	ACAGATGGTCGAGGTCATGCG	0.423000													7	73					0.000157383	0.000218546	0.038147	1	0
SLCO5A1	81796	broad.mit.edu	37	8	70585515	70585515	+	Silent	SNP	G	G	C			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr8:70585515G>C	ENST00000260126.3	-	10	2842	c.2136C>G	c.(2134-2136)acC>acG	p.T712T	SLCO5A1_ENST00000524945.1_3'UTR|SLCO5A1_ENST00000530307.1_Silent_p.T657T	NM_030958.2	NP_112220.2	Q9H2Y9	SO5A1_HUMAN	solute carrier organic anion transporter family, member 5A1	712						integral to membrane|plasma membrane	transporter activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(11)|lung(24)|ovary(3)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	53	Breast(64;0.0654)		Epithelial(68;0.0141)|OV - Ovarian serous cystadenocarcinoma(28;0.0315)|all cancers(69;0.0594)			AGAGCATGCAGGTGGTGTCAA	0.483000													21	203					0	0	0.076483	0	0
TTN	7273	broad.mit.edu	37	2	179636129	179636129	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr2:179636129T>C	ENST00000589042.1	-	34	8149	c.7925A>G	c.(7924-7926)gAa>gGa	p.E2642G	TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.E2596G|TTN_ENST00000342175.6_Missense_Mutation_p.E2596G|TTN_ENST00000460472.2_Missense_Mutation_p.E2596G|TTN_ENST00000342992.6_Missense_Mutation_p.E2642G|TTN_ENST00000591111.1_Missense_Mutation_p.E2642G|TTN_ENST00000360870.5_Missense_Mutation_p.E2642G	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	2378	Ig-like 15.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GTTGGCAACTTCACATTCAAA	0.488000													6	61					0	0	0.029380	0	0
JARID2	3720	broad.mit.edu	37	6	15487658	15487658	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr6:15487658A>T	ENST00000341776.2	+	6	1035	c.791A>T	c.(790-792)cAg>cTg	p.Q264L	JARID2_ENST00000541660.1_Missense_Mutation_p.Q226L|JARID2_ENST00000397311.3_Missense_Mutation_p.Q92L	NM_004973.3	NP_004964.2	Q92833	JARD2_HUMAN	jumonji, AT rich interactive domain 2	264					central nervous system development|chromatin modification|negative regulation of histone methylation|positive regulation of histone H3-K9 methylation|stem cell differentiation|transcription, DNA-dependent		chromatin binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(10)|kidney(2)|large_intestine(15)|lung(19)|ovary(3)|pancreas(1)|prostate(5)|stomach(1)	59	Breast(50;0.0142)|Ovarian(93;0.103)	all_hematologic(90;0.00612)				CGCCGGGAGCAGGCTTCAGCT	0.632000													6	24					0	0	0.047766	0	0
COL19A1	1310	broad.mit.edu	37	6	70745809	70745809	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr6:70745809C>T	ENST00000322773.4	+	14	1250	c.1148C>T	c.(1147-1149)cCc>cTc	p.P383L		NM_001858.4	NP_001849.2	Q14993	COJA1_HUMAN	collagen, type XIX, alpha 1	383	Triple-helical region 2 (COL2).				cell differentiation|cell-cell adhesion|extracellular matrix organization|skeletal system development	collagen	extracellular matrix structural constituent|protein binding, bridging			breast(4)|central_nervous_system(3)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(5)|kidney(4)|large_intestine(8)|lung(54)|ovary(3)|prostate(2)|skin(10)|upper_aerodigestive_tract(4)|urinary_tract(2)	109						GATACAGGACCCCCAGGACCA	0.323000													5	36					0	0	0.021553	0	0
CNTN5	53942	broad.mit.edu	37	11	99827596	99827596	+	Silent	SNP	G	G	T			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr11:99827596G>T	ENST00000524871.1	+	8	1022	c.732G>T	c.(730-732)cgG>cgT	p.R244R	CNTN5_ENST00000527185.1_Silent_p.R244R|CNTN5_ENST00000418526.2_Silent_p.R170R|CNTN5_ENST00000528682.1_Silent_p.R244R|CNTN5_ENST00000279463.3_Silent_p.R244R	NM_014361.3	NP_055176.1	O94779	CNTN5_HUMAN	contactin 5	244	Ig-like C2-type 2.				cell adhesion	anchored to membrane|plasma membrane	protein binding			NS(2)|breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(12)|lung(38)|ovary(2)|pancreas(2)|prostate(2)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(1)	81		all_hematologic(158;1.22e-05)|Acute lymphoblastic leukemia(157;3.81e-05)|Melanoma(852;0.219)		BRCA - Breast invasive adenocarcinoma(274;0.00146)|KIRC - Kidney renal clear cell carcinoma(183;0.156)|Kidney(183;0.196)		AAGACAGCCGGCGGTTCATCT	0.408000													8	77					0.00448238	0.00554151	0.047766	1	0
KRT36	8689	broad.mit.edu	37	17	39644564	39644564	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr17:39644564C>A	ENST00000393986.2	-	4	692	c.480G>T	c.(478-480)aaG>aaT	p.K160N	KRT36_ENST00000328119.6_Missense_Mutation_p.K210N			O76013	KRT36_HUMAN	keratin 36	210	Coil 1B.|Rod.					intermediate filament	protein binding|structural constituent of epidermis			breast(2)|cervix(1)|kidney(2)|large_intestine(3)|lung(8)|skin(1)	17		Breast(137;0.000286)				CCAGGTCAGCCTTGCACAGGG	0.582000													11	67					3.07112e-06	4.73599e-06	0.080935	1	0
OR5H6	79295	broad.mit.edu	37	3	97983440	97983440	+	Silent	SNP	G	G	A			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr3:97983440G>A	ENST00000383696.2	+	1	353	c.312G>A	c.(310-312)aaG>aaA	p.K104K	RP11-325B23.2_ENST00000508616.1_lincRNA	NM_001005479.1	NP_001005479.1	Q8NGV6	OR5H6_HUMAN	olfactory receptor, family 5, subfamily H, member 6 (gene/pseudogene)	104					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(2)|endometrium(1)|large_intestine(4)|lung(20)|ovary(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	34						TCTTAGCTAAGAGTAAGATGA	0.393000													7	94					0	0	0.038147	0	0
C14orf28	122525	broad.mit.edu	37	14	45369771	45369771	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr14:45369771A>T	ENST00000325192.3	+	2	408	c.133A>T	c.(133-135)Aca>Tca	p.T45S	RP11-857B24.5_ENST00000555157.1_RNA|C14orf28_ENST00000557112.1_Missense_Mutation_p.T45S	NM_001017923.1	NP_001017923.1	Q4W4Y0	CN028_HUMAN	chromosome 14 open reading frame 28	45										endometrium(1)|large_intestine(3)|liver(1)|lung(4)|ovary(2)	11						AGTATCCTGTACACCACTCTA	0.358000													3	33					0	0	0.014758	0	0
NUP188	23511	broad.mit.edu	37	9	131752435	131752435	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr9:131752435A>G	ENST00000372577.2	+	25	2591	c.2570A>G	c.(2569-2571)aAa>aGa	p.K857R		NM_015354.1	NP_056169.1	Q5SRE5	NU188_HUMAN	nucleoporin 188kDa	857					carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear pore	protein binding			breast(2)|central_nervous_system(3)|endometrium(6)|kidney(4)|large_intestine(9)|lung(20)|ovary(6)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	60						GTTCTAGCCAAATACATCTAC	0.463000													23	198					0	0	0.116897	0	0
ANK2	287	broad.mit.edu	37	4	114279001	114279001	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr4:114279001A>T	ENST00000357077.4	+	38	9280	c.9227A>T	c.(9226-9228)cAg>cTg	p.Q3076L	ANK2_ENST00000264366.6_Missense_Mutation_p.Q3043L|ANK2_ENST00000394537.3_Intron|ANK2_ENST00000510275.2_Intron|ANK2_ENST00000509550.1_Intron|ANK2_ENST00000506722.1_Intron	NM_001148.4	NP_001139.3	Q01484	ANK2_HUMAN	ankyrin 2, neuronal	3043					axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding			NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(10)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(54)|liver(2)|lung(112)|ovary(8)|pancreas(1)|prostate(7)|skin(11)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(10)	248		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		AGACAATCACAGGGTACCACC	0.463000													11	78					0	0	0.080935	0	0
NRAP	4892	broad.mit.edu	37	10	115391688	115391688	+	Silent	SNP	C	C	A			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr10:115391688C>A	ENST00000369358.4	-	17	1912	c.1668G>T	c.(1666-1668)ggG>ggT	p.G556G	NRAP_ENST00000360478.3_Silent_p.G521G|NRAP_ENST00000369360.3_Silent_p.G521G|NRAP_ENST00000359988.3_Silent_p.G556G			Q86VF7	NRAP_HUMAN	nebulin-related anchoring protein	556						fascia adherens|muscle tendon junction	actin binding|muscle alpha-actinin binding|zinc ion binding			autonomic_ganglia(1)|breast(2)|central_nervous_system(4)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(18)|lung(39)|ovary(6)|prostate(3)|skin(1)|stomach(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	95		Colorectal(252;0.0233)|Breast(234;0.188)		Epithelial(162;0.00392)|all cancers(201;0.00569)		CAAATCCTTTCCCCTTTGTCT	0.453000													6	150					0.00198382	0.00247344	0.029380	1	0
TANC1	85461	broad.mit.edu	37	2	160020027	160020027	+	Silent	SNP	C	C	T			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr2:160020027C>T	ENST00000263635.6	+	8	1153	c.916C>T	c.(916-918)Cta>Tta	p.L306L	TANC1_ENST00000454300.1_Silent_p.L200L	NM_001145909.1|NM_033394.2	NP_001139381.1|NP_203752.2	Q9C0D5	TANC1_HUMAN	tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1	306						cell junction|postsynaptic density|postsynaptic membrane	binding			breast(3)|central_nervous_system(4)|cervix(2)|endometrium(6)|kidney(4)|large_intestine(9)|lung(25)|ovary(7)|pancreas(1)|prostate(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(2)	77						CTCCAGCTCACTAATAATGCC	0.552000													3	37					0	0	0.115264	0	0
PAX5	5079	broad.mit.edu	37	9	36882059	36882059	+	Silent	SNP	G	G	A	rs144574685	byFrequency	TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr9:36882059G>A	ENST00000358127.4	-	8	1028	c.954C>T	c.(952-954)caC>caT	p.H318H	PAX5_ENST00000520154.1_Intron|PAX5_ENST00000446742.1_Intron|PAX5_ENST00000523145.1_Intron|PAX5_ENST00000414447.1_Silent_p.H275H|PAX5_ENST00000377852.2_Intron|PAX5_ENST00000523241.1_Intron|PAX5_ENST00000377853.2_Silent_p.H318H|PAX5_ENST00000377847.2_Intron|PAX5_ENST00000520281.1_Silent_p.H275H|PAX5_ENST00000522003.1_Silent_p.H210H	NM_016734.1	NP_057953.1	Q02548	PAX5_HUMAN	paired box 5	318					cell differentiation|humoral immune response|nervous system development|organ morphogenesis|spermatogenesis|transcription from RNA polymerase II promoter	nucleus	DNA binding	p.?(22)	PAX5/JAK2(18)	NS(1)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(151)|kidney(1)|lung(10)|prostate(1)|skin(1)	171		all_cancers(2;3.46e-10)|Acute lymphoblastic leukemia(2;7.09e-56)|all_hematologic(2;6.65e-44)		GBM - Glioblastoma multiforme(29;0.0108)		CGGGGGGGACGTGTGGAGGGT	0.642000			"""T, Mis, D, F, S"""	"""IGH@, ETV6, PML, FOXP1, ZNF521, ELN"""	"""NHL, ALL, B-ALL"""								4	12					0	0	0.009096	0	0
KCNG3	170850	broad.mit.edu	37	2	42671148	42671148	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr2:42671148C>A	ENST00000306078.1	-	2	1832	c.1237G>T	c.(1237-1239)Gtg>Ttg	p.V413L	KCNG3_ENST00000394973.4_Missense_Mutation_p.V402L	NM_133329.5|NM_172344.2	NP_579875.1|NP_758847.1	Q8TAE7	KCNG3_HUMAN	potassium voltage-gated channel, subfamily G, member 3	413						endoplasmic reticulum|voltage-gated potassium channel complex	protein binding			central_nervous_system(1)|large_intestine(1)|lung(2)|upper_aerodigestive_tract(2)	6						TAACACTGCACAAAGCTATGG	0.393000													6	82					3.59834e-05	5.32481e-05	0.021553	1	0
NRXN3	9369	broad.mit.edu	37	14	80164064	80164064	+	Silent	SNP	C	C	G			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr14:80164064C>G	ENST00000281127.7	+	4	1572	c.693C>G	c.(691-693)ctC>ctG	p.L231L	RP11-242P2.1_ENST00000553322.1_RNA|NRXN3_ENST00000335750.5_Silent_p.L863L|NRXN3_ENST00000557594.1_Silent_p.L231L|NRXN3_ENST00000556003.1_Intron|NRXN3_ENST00000428277.2_Silent_p.L261L|NRXN3_ENST00000554719.1_Silent_p.L863L	NM_138970.3	NP_620426.2	Q9HDB5	NRX3B_HUMAN	neurexin 3	231	Laminin G-like.				angiogenesis|cell adhesion	integral to membrane				NS(1)|breast(4)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(23)|lung(40)|ovary(3)|pancreas(2)|prostate(5)|skin(7)|upper_aerodigestive_tract(9)|urinary_tract(1)	104		Renal(4;0.00876)		BRCA - Breast invasive adenocarcinoma(234;0.00544)|Kidney(3;0.029)|KIRC - Kidney renal clear cell carcinoma(182;0.223)		TCTCTGGGCTCTATTATGATG	0.473000													8	105					0	0	0.047766	0	0
ERAP2	64167	broad.mit.edu	37	5	96239250	96239250	+	Silent	SNP	G	G	T			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr5:96239250G>T	ENST00000437043.3	+	13	2709	c.1998G>T	c.(1996-1998)gtG>gtT	p.V666V	CTD-2260A17.2_ENST00000501338.1_Intron|ERAP2_ENST00000379904.4_Silent_p.V621V	NM_001130140.1|NM_022350.3	NP_001123612.1|NP_071745.1	Q6P179	ERAP2_HUMAN	endoplasmic reticulum aminopeptidase 2	666					antigen processing and presentation of endogenous peptide antigen via MHC class I|proteolysis|regulation of blood pressure	endoplasmic reticulum lumen|endoplasmic reticulum membrane|integral to membrane	aminopeptidase activity|metallopeptidase activity|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(6)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	24		all_cancers(142;0.000311)|all_epithelial(76;1.54e-06)|all_lung(232;0.0131)|Lung NSC(167;0.0161)|Colorectal(57;0.0596)|Ovarian(225;0.105)		COAD - Colon adenocarcinoma(37;0.0703)		TTCATGATGTGTTTCAGCTAG	0.408000													5	40					0.00116845	0.00148205	0.021553	1	0
KIF21B	23046	broad.mit.edu	37	1	200967546	200967546	+	Silent	SNP	T	T	A			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr1:200967546T>A	ENST00000332129.2	-	14	2359	c.2043A>T	c.(2041-2043)acA>acT	p.T681T	KIF21B_ENST00000461742.2_Silent_p.T681T|KIF21B_ENST00000360529.5_Silent_p.T681T|KIF21B_ENST00000422435.2_Silent_p.T681T	NM_001252102.1|NM_001252103.1|NM_017596.3	NP_001239031.1|NP_001239032.1|NP_060066.2	O75037	KI21B_HUMAN	kinesin family member 21B	681					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(15)|kidney(4)|large_intestine(8)|liver(1)|lung(27)|ovary(3)|pancreas(1)|prostate(5)|skin(8)|stomach(2)|urinary_tract(2)	83						GCTCCAGCTGTGTGTCTCGGA	0.607000													7	36					0	0	0.038147	0	0
KIAA1024	23251	broad.mit.edu	37	15	79749995	79749995	+	Silent	SNP	C	C	T			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr15:79749995C>T	ENST00000305428.3	+	2	1581	c.1506C>T	c.(1504-1506)caC>caT	p.H502H		NM_015206.2	NP_056021.1	Q9UPX6	K1024_HUMAN	KIAA1024	502						integral to membrane				central_nervous_system(2)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(13)|lung(23)|ovary(2)|pancreas(2)|prostate(1)	49						GTGACAGGCACACCATGAAGC	0.537000													6	51					0	0	0.029380	0	0
LMX1A	4009	broad.mit.edu	37	1	165182944	165182944	+	Silent	SNP	G	G	T			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr1:165182944G>T	ENST00000342310.3	-	5	985	c.603C>A	c.(601-603)atC>atA	p.I201I	LMX1A_ENST00000294816.2_Silent_p.I201I|LMX1A_ENST00000367893.4_Silent_p.I201I	NM_177398.3	NP_796372.1	Q8TE12	LMX1A_HUMAN	LIM homeobox transcription factor 1, alpha	201						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(2)|biliary_tract(1)|central_nervous_system(3)|cervix(2)|endometrium(4)|large_intestine(6)|lung(10)|pancreas(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(4)	35	all_hematologic(923;0.248)					GAGTTGTCAAGATGGTTCTCG	0.537000													13	204					1.05317e-09	1.81517e-09	0.119110	1	0
AUTS2	26053	broad.mit.edu	37	7	70246623	70246623	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr7:70246623A>G	ENST00000342771.4	+	15	2348	c.2027A>G	c.(2026-2028)cAt>cGt	p.H676R	AUTS2_ENST00000406775.2_Missense_Mutation_p.H652R	NM_015570.2	NP_056385.1	Q8WXX7	AUTS2_HUMAN	autism susceptibility candidate 2	676										breast(2)|central_nervous_system(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(14)|ovary(4)|prostate(2)|skin(4)|urinary_tract(1)	50		all_cancers(73;0.0264)|all_epithelial(88;0.0198)|Lung NSC(55;0.0599)|all_lung(88;0.093)		LUSC - Lung squamous cell carcinoma(90;0.082)|Lung(90;0.186)		TCAGACCCACATAAGCTGGAC	0.547000													5	179					0	0	0.021553	0	0
ACAP2	23527	broad.mit.edu	37	3	195063225	195063225	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr3:195063225T>A	ENST00000326793.6	-	6	733	c.503A>T	c.(502-504)cAc>cTc	p.H168L		NM_012287.5	NP_036419.3	Q15057	ACAP2_HUMAN	ArfGAP with coiled-coil, ankyrin repeat and PH domains 2	168	BAR.				regulation of ARF GTPase activity		ARF GTPase activator activity|zinc ion binding			cervix(2)|endometrium(2)|kidney(4)|large_intestine(5)|lung(10)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(2)	27						GAGGGCTATGTGTCGGAAACA	0.378000													5	65					0	0	0.021553	0	0
ACSF3	197322	broad.mit.edu	37	16	89212437	89212437	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr16:89212437G>T	ENST00000317447.4	+	10	1970	c.1593G>T	c.(1591-1593)agG>agT	p.R531S	ACSF3_ENST00000406948.3_Missense_Mutation_p.R531S|ACSF3_ENST00000378345.4_Missense_Mutation_p.R266S|ACSF3_ENST00000537116.1_3'UTR	NM_001127214.2|NM_001243279.1|NM_174917.3	NP_001120686.1|NP_001230208.1|NP_777577.2	Q4G176	ACSF3_HUMAN	acyl-CoA synthetase family member 3	531					fatty acid metabolic process	mitochondrion	acid-thiol ligase activity|ATP binding			central_nervous_system(1)|endometrium(1)|kidney(2)|lung(9)|prostate(1)|urinary_tract(1)	15				BRCA - Breast invasive adenocarcinoma(80;0.0281)		TGTCCCACAGGGAGCTCAAAG	0.612000													3	32					0.00909568	0.0106177	0.009096	1	0
GPR98	84059	broad.mit.edu	37	5	90040909	90040909	+	Nonsense_Mutation	SNP	G	G	A			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr5:90040909G>A	ENST00000405460.2	+	51	10692	c.10596G>A	c.(10594-10596)tgG>tgA	p.W3532*		NM_032119.3	NP_115495.3	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98	3532					cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(4)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(18)|large_intestine(46)|liver(2)|lung(80)|ovary(12)|pancreas(5)|prostate(1)|skin(50)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(6)	269		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		TTTACTGCTGGAATTCGGAGC	0.393000													6	270					0	0	0.038147	0	0
FAM47B	170062	broad.mit.edu	37	X	34962649	34962649	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chrX:34962649G>T	ENST00000329357.5	+	1	1737	c.1701G>T	c.(1699-1701)ttG>ttT	p.L567F		NM_152631.2	NP_689844.2	Q8NA70	FA47B_HUMAN	family with sequence similarity 47, member B	567										breast(3)|central_nervous_system(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(13)|lung(28)|ovary(4)|prostate(3)|skin(2)|upper_aerodigestive_tract(3)	71						ATGAACCTTTGATTGACCCCA	0.468000													11	197					3.86212e-05	5.68644e-05	0.069234	1	0
FOXP2	93986	broad.mit.edu	37	7	114294037	114294037	+	Silent	SNP	C	C	A			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr7:114294037C>A	ENST00000393500.3	+	16	1834	c.1014C>A	c.(1012-1014)ccC>ccA	p.P338P	FOXP2_ENST00000403559.4_Silent_p.P430P|FOXP2_ENST00000393498.2_Silent_p.P392P|FOXP2_ENST00000393489.3_Silent_p.P321P|FOXP2_ENST00000393491.3_Silent_p.P321P|FOXP2_ENST00000390668.3_Silent_p.P437P|FOXP2_ENST00000393494.2_Silent_p.P413P|FOXP2_ENST00000350908.4_Silent_p.P413P|FOXP2_ENST00000360232.4_Silent_p.P413P|FOXP2_ENST00000408937.3_Silent_p.P438P			O15409	FOXP2_HUMAN	forkhead box P2	413					camera-type eye development|caudate nucleus development|cerebellum development|cerebral cortex development|embryo development|growth|lung alveolus development|negative regulation of transcription, DNA-dependent|pattern specification process|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of mesenchymal cell proliferation|post-embryonic development|putamen development|regulation of sequence-specific DNA binding transcription factor activity|righting reflex|skeletal muscle tissue development|smooth muscle tissue development|vocal learning	cytoplasm|transcription factor complex	chromatin binding|DNA bending activity|double-stranded DNA binding|promoter binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|zinc ion binding			breast(3)|endometrium(7)|kidney(4)|large_intestine(7)|lung(22)|ovary(4)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	52						ACATGCGACCCTCAGAGCCCA	0.393000													13	143					8.60227e-14	1.56551e-13	0.146539	1	0
CNOT1	23019	broad.mit.edu	37	16	58572121	58572121	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr16:58572121C>G	ENST00000317147.5	-	37	5517	c.5185G>C	c.(5185-5187)Gag>Cag	p.E1729Q	CNOT1_ENST00000569240.1_Missense_Mutation_p.E1724Q|CNOT1_ENST00000245138.4_Missense_Mutation_p.E580Q	NM_001265612.1|NM_016284.4	NP_001252541.1|NP_057368.3	A5YKK6	CNOT1_HUMAN	CCR4-NOT transcription complex, subunit 1	1729					nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol				breast(1)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(24)|lung(25)|ovary(4)|prostate(6)|skin(3)|upper_aerodigestive_tract(2)	87				Kidney(780;0.0722)|OV - Ovarian serous cystadenocarcinoma(108;0.173)|Epithelial(162;0.239)		ATTAGCAGCTCCACAGCCTCC	0.383000													5	64					0	0	0.021553	0	0
KIF26B	55083	broad.mit.edu	37	1	245848860	245848860	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr1:245848860G>A	ENST00000366518.4	+	9	1536	c.1432G>A	c.(1432-1434)Gag>Aag	p.E478K	KIF26B_ENST00000407071.2_Missense_Mutation_p.E859K			Q2KJY2	KI26B_HUMAN	kinesin family member 26B	859	Kinesin-motor.				microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(21)|ovary(4)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	51	all_cancers(71;3.86e-05)|all_epithelial(71;0.000121)|Ovarian(71;0.0412)|all_lung(81;0.0498)|Lung NSC(105;0.0708)|Breast(184;0.127)		OV - Ovarian serous cystadenocarcinoma(106;0.022)			CTCCAGCAGCGAGCAGTCCTG	0.647000													4	13					0	0	0.009096	0	0
CNTNAP2	26047	broad.mit.edu	37	7	147336343	147336343	+	Nonsense_Mutation	SNP	C	C	A			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr7:147336343C>A	ENST00000361727.3	+	13	2559	c.2043C>A	c.(2041-2043)taC>taA	p.Y681*		NM_014141.5	NP_054860.1	Q9UHC6	CNTP2_HUMAN	contactin associated protein-like 2	681	Fibrinogen C-terminal.				behavior|cell adhesion|clustering of voltage-gated potassium channels|limbic system development|neuron recognition|signal transduction|striatum development|superior temporal gyrus development|thalamus development|transmission of nerve impulse	axolemma|cell body fiber|dendrite|juxtaparanode region of axon|voltage-gated potassium channel complex	receptor binding			NS(3)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(21)|lung(105)|ovary(9)|pancreas(2)|prostate(5)|skin(7)|stomach(3)|upper_aerodigestive_tract(6)|urinary_tract(3)	188	Melanoma(164;0.153)	all_cancers(3;3.51e-10)|all_epithelial(3;1.4e-05)|Myeloproliferative disorder(3;0.00452)|Lung NSC(3;0.0067)|all_lung(3;0.00794)	OV - Ovarian serous cystadenocarcinoma(82;0.0319)			GTGCCGAGTACTGCGAGCAGT	0.483000										HNSCC(39;0.1)			12	66					4.36969e-10	7.75951e-10	0.105934	1	0
DARC	2532	broad.mit.edu	37	1	159175743	159175743	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr1:159175743G>A	ENST00000537147.1	+	3	1357	c.514G>A	c.(514-516)Gga>Aga	p.G172R	DARC_ENST00000368121.2_Missense_Mutation_p.G174R|DARC_ENST00000368122.2_Missense_Mutation_p.G172R			Q16570	DUFFY_HUMAN	Duffy blood group, atypical chemokine receptor	172					defense response	integral to membrane|plasma membrane	C-C chemokine binding|chemokine receptor activity			large_intestine(2)|lung(1)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	8	all_hematologic(112;0.0429)					GCTCACTGTGGGAATTTGGGG	0.632000													3	11					0	0	0.009096	0	0
CXorf22	170063	broad.mit.edu	37	X	35944189	35944189	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chrX:35944189C>G	ENST00000297866.5	+	2	371	c.305C>G	c.(304-306)aCa>aGa	p.T102R		NM_152632.3	NP_689845.2	Q6ZTR5	CX022_HUMAN	chromosome X open reading frame 22	102										breast(2)|central_nervous_system(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(18)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(3)	44						CTTCAGATGACAGCTATGGTG	0.363000													9	50					0	0	0.080935	0	0
PRKDC	5591	broad.mit.edu	37	8	48689457	48689457	+	Missense_Mutation	SNP	T	T	G			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr8:48689457T>G	ENST00000314191.2	-	86	12183	c.12127A>C	c.(12127-12129)Ata>Cta	p.I4043L	PRKDC_ENST00000338368.3_Missense_Mutation_p.I4012L|PRKDC_ENST00000523565.1_5'UTR	NM_006904.6	NP_008835.5	P78527	PRKDC_HUMAN	protein kinase, DNA-activated, catalytic polypeptide	4044					cellular response to insulin stimulus|double-strand break repair via nonhomologous end joining|peptidyl-serine phosphorylation|positive regulation of transcription from RNA polymerase II promoter	DNA-dependent protein kinase-DNA ligase 4 complex|transcription factor complex	ATP binding|DNA binding|DNA-dependent protein kinase activity|transcription factor binding			NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(9)|cervix(3)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(30)|lung(56)|ovary(6)|pancreas(1)|prostate(8)|skin(7)	147		all_cancers(86;0.0336)|all_epithelial(80;0.00111)|Lung NSC(129;0.00363)|all_lung(136;0.00391)				GCGTAACATATTTTCTGTCGG	0.363000								Non-homologous end-joining					3	29					0	0	0.115264	0	0
GABRG1	2565	broad.mit.edu	37	4	46060352	46060352	+	Silent	SNP	C	C	A			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr4:46060352C>A	ENST00000295452.4	-	7	965	c.798G>T	c.(796-798)ctG>ctT	p.L266L		NM_173536.3	NP_775807.2	Q8N1C3	GBRG1_HUMAN	gamma-aminobutyric acid (GABA) A receptor, gamma 1	266					gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity			breast(2)|central_nervous_system(5)|endometrium(3)|kidney(4)|large_intestine(11)|liver(1)|lung(37)|ovary(2)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	76				Lung(65;0.106)|LUSC - Lung squamous cell carcinoma(721;0.23)		TTCTTCTGCTCAGGTCAAAAA	0.303000													5	68					5.4927e-09	9.19635e-09	0.047766	1	0
PCSK5	5125	broad.mit.edu	37	9	78938198	78938198	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr9:78938198T>A	ENST00000545128.1	+	31	4790	c.4252T>A	c.(4252-4254)Tgc>Agc	p.C1418S		NM_001190482.1	NP_001177411.1	Q92824	PCSK5_HUMAN	proprotein convertase subtilisin/kexin type 5	667					anterior/posterior pattern formation|cell-cell signaling|cytokine biosynthetic process|embryo implantation|embryonic digestive tract development|embryonic skeletal system development|heart development|kidney development|limb morphogenesis|nerve growth factor processing|nerve growth factor receptor signaling pathway|peptide biosynthetic process|renin secretion into blood stream|respiratory tube development|signal peptide processing|viral assembly, maturation, egress, and release	extracellular space|Golgi lumen|stored secretory granule	peptide binding|serine-type endopeptidase activity			NS(1)|breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(7)|liver(2)|lung(25)|ovary(2)|pancreas(1)|prostate(2)|skin(3)	55						GACTAAGGAGTGCAGAGGTAA	0.502000													6	31					0	0	0.021553	0	0
PLCB4	5332	broad.mit.edu	37	20	9400527	9400527	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr20:9400527G>A	ENST00000378501.2	+	22	2104	c.2089G>A	c.(2089-2091)Ggt>Agt	p.G697S	PLCB4_ENST00000378473.3_Missense_Mutation_p.G709S|PLCB4_ENST00000334005.3_Missense_Mutation_p.G697S|PLCB4_ENST00000278655.4_Missense_Mutation_p.G697S|PLCB4_ENST00000414679.2_Missense_Mutation_p.G709S|PLCB4_ENST00000378493.1_Missense_Mutation_p.G697S|PLCB4_ENST00000492632.1_3'UTR	NM_000933.3	NP_000924.3	Q15147	PLCB4_HUMAN	phospholipase C, beta 4	697	C2.				intracellular signal transduction|lipid catabolic process	cytosol	calcium ion binding|phosphatidylinositol phospholipase C activity|protein binding|signal transducer activity			NS(2)|breast(4)|cervix(1)|endometrium(2)|kidney(4)|large_intestine(11)|liver(4)|lung(34)|ovary(3)|pancreas(1)|prostate(1)|skin(19)|upper_aerodigestive_tract(1)	87						TCCTGTTGATGGTGTTATTGC	0.423000													7	69					0	0	0.047766	0	0
MAGEB4	4115	broad.mit.edu	37	X	30261234	30261234	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chrX:30261234A>G	ENST00000378982.2	+	1	1178	c.982A>G	c.(982-984)Aca>Gca	p.T328A		NM_002367.3	NP_002358.1	O15481	MAGB4_HUMAN	melanoma antigen family B, 4	328										breast(2)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(12)|ovary(1)|skin(2)|upper_aerodigestive_tract(2)	27						GCGTGGCACTACAGCCATGAC	0.522000													3	19					0	0	0.009096	0	0
TMEM132E	124842	broad.mit.edu	37	17	32956216	32956216	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr17:32956216T>A	ENST00000321639.5	+	5	1389	c.1061T>A	c.(1060-1062)cTg>cAg	p.L354Q		NM_207313.1	NP_997196.1	Q6IEE7	T132E_HUMAN	transmembrane protein 132E	354						integral to membrane				breast(1)|central_nervous_system(2)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(10)|lung(28)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	57				BRCA - Breast invasive adenocarcinoma(366;0.231)		ATCCTGCCCCTGGCCATGGTG	0.577000													4	34					0	0	0.021553	0	0
ADAMTS20	80070	broad.mit.edu	37	12	43945021	43945021	+	Silent	SNP	G	G	T			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr12:43945021G>T	ENST00000389420.3	-	2	143	c.144C>A	c.(142-144)gtC>gtA	p.V48V	ADAMTS20_ENST00000553158.1_Silent_p.V48V	NM_025003.3	NP_079279.3	P59510	ATS20_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 20	48						proteinaceous extracellular matrix	zinc ion binding			breast(1)|central_nervous_system(6)|endometrium(3)|kidney(4)|large_intestine(11)|liver(1)|lung(43)|ovary(4)|pancreas(3)|prostate(5)|skin(12)|upper_aerodigestive_tract(1)|urinary_tract(1)	95	all_cancers(12;2.6e-05)|Lung SC(27;0.184)	Lung NSC(34;0.0569)|all_lung(34;0.129)		GBM - Glioblastoma multiforme(48;0.0473)		CAAACTCATTGACCCGCTCGG	0.587000													5	51					0.00116845	0.00148205	0.021553	1	0
DNAH8	1769	broad.mit.edu	37	6	38866152	38866152	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr6:38866152T>C	ENST00000359357.3	+	59	8662	c.8408T>C	c.(8407-8409)aTt>aCt	p.I2803T	DNAH8_ENST00000441566.1_Missense_Mutation_p.I2767T|DNAH8_ENST00000449981.2_Missense_Mutation_p.I3020T					dynein, axonemal, heavy chain 8											NS(7)|breast(9)|central_nervous_system(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(3)|kidney(16)|large_intestine(44)|liver(4)|lung(101)|ovary(7)|pancreas(2)|prostate(8)|skin(28)|stomach(4)|upper_aerodigestive_tract(6)|urinary_tract(4)	260						ACTCATCTTATTAAGGTCCTA	0.299000													8	52					0	0	0.038147	0	0
SRP72	6731	broad.mit.edu	37	4	57357634	57357634	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr4:57357634C>G	ENST00000342756.5	+	16	2261	c.1540C>G	c.(1540-1542)Cta>Gta	p.L514V	SRP72_ENST00000510663.1_Missense_Mutation_p.L453V	NM_006947.3	NP_008878.3	O76094	SRP72_HUMAN	signal recognition particle 72kDa	514					response to drug|SRP-dependent cotranslational protein targeting to membrane	cytosol|nucleolus|plasma membrane|signal recognition particle, endoplasmic reticulum targeting	7S RNA binding|signal recognition particle binding			breast(2)|endometrium(4)|kidney(1)|large_intestine(4)|liver(2)|lung(7)|ovary(2)	22	Glioma(25;0.08)|all_neural(26;0.101)					TAGTATGTCTCTAAAAGTAGA	0.373000													7	112					0	0	0.029380	0	0
OR2T33	391195	broad.mit.edu	37	1	248436331	248436331	+	Silent	SNP	G	G	T			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr1:248436331G>T	ENST00000318021.2	-	1	807	c.786C>A	c.(784-786)tcC>tcA	p.S262S		NM_001004695.1	NP_001004695.1	Q8NG76	O2T33_HUMAN	olfactory receptor, family 2, subfamily T, member 33	262					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(2)|breast(1)|endometrium(6)|kidney(1)|large_intestine(10)|lung(41)|ovary(1)|prostate(1)|skin(4)	67	all_cancers(71;0.000124)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			TGGACCTATGGGATTTGGGTC	0.478000													9	164					2.80697e-09	4.80961e-09	0.080935	1	0
SMC3	9126	broad.mit.edu	37	10	112361781	112361781	+	Missense_Mutation	SNP	A	A	C			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr10:112361781A>C	ENST00000361804.4	+	25	3076	c.2950A>C	c.(2950-2952)Aaa>Caa	p.K984Q		NM_005445.3	NP_005436.1	Q9UQE7	SMC3_HUMAN	structural maintenance of chromosomes 3	984					cell division|DNA mediated transformation|DNA repair|meiosis|mitotic metaphase/anaphase transition|mitotic prometaphase|mitotic spindle organization|negative regulation of DNA endoreduplication|signal transduction|sister chromatid cohesion	basement membrane|chromatin|chromosome, centromeric region|cytoplasm|meiotic cohesin complex|nuclear matrix|nucleoplasm|spindle pole	ATP binding|dynein binding|microtubule motor activity|protein heterodimerization activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|large_intestine(5)|lung(13)|ovary(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	39		Breast(234;0.0848)|Lung NSC(174;0.238)		Epithelial(162;0.00206)|all cancers(201;0.0227)|BRCA - Breast invasive adenocarcinoma(275;0.127)		CCATGTTAACAAAAAGGCTTT	0.308000													7	61					0	0	0.038147	0	0
MYH10	4628	broad.mit.edu	37	17	8526461	8526461	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr17:8526461A>G	ENST00000360416.3	-	2	242	c.104T>C	c.(103-105)cTa>cCa	p.L35P	MYH10_ENST00000269243.4_Missense_Mutation_p.L35P|MYH10_ENST00000396239.1_Missense_Mutation_p.L35P|MYH10_ENST00000379980.4_Missense_Mutation_p.L35P	NM_001256012.1	NP_001242941.1	P35580	MYH10_HUMAN	myosin, heavy chain 10, non-muscle	35	Myosin head-like.				actin filament-based movement|axon guidance|cytokinesis after mitosis|regulation of cell shape	cell cortex|cleavage furrow|midbody|myosin complex|stress fiber	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity			breast(5)|endometrium(9)|kidney(2)|large_intestine(16)|lung(9)|ovary(3)|prostate(3)|skin(4)|stomach(1)	52						AATCCACACTAGCTTTTTAGC	0.483000													10	99					0	0	0.080935	0	0
CHD7	55636	broad.mit.edu	37	8	61654705	61654705	+	Silent	SNP	G	G	T			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr8:61654705G>T	ENST00000423902.2	+	2	1193	c.714G>T	c.(712-714)gtG>gtT	p.V238V	CHD7_ENST00000525508.1_Silent_p.V238V|CHD7_ENST00000524602.1_Silent_p.V238V	NM_017780.3	NP_060250.2	Q9P2D1	CHD7_HUMAN	chromodomain helicase DNA binding protein 7	238					central nervous system development|chromatin modification|cognition|cranial nerve development|face development|heart morphogenesis|in utero embryonic development|inner ear morphogenesis|nose development|palate development|regulation of growth hormone secretion|regulation of transcription, DNA-dependent|retina development in camera-type eye|skeletal system development|T cell differentiation|transcription, DNA-dependent	nucleus	ATP binding|chromatin binding|DNA binding|helicase activity			NS(1)|breast(6)|central_nervous_system(8)|cervix(2)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(16)|lung(49)|ovary(4)|pancreas(2)|prostate(4)|skin(2)|urinary_tract(3)	123		all_cancers(86;0.2)|all_lung(136;0.0402)|Lung NSC(129;0.0459)|all_epithelial(80;0.0477)	BRCA - Breast invasive adenocarcinoma(89;0.143)			TGTCCCACGTGCCCCAGCAGA	0.577000													5	169					0.000602214	0.000794815	0.014758	1	0
KRTAP11-1	337880	broad.mit.edu	37	21	32253488	32253488	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr21:32253488C>A	ENST00000332378.4	-	1	386	c.356G>T	c.(355-357)aGt>aTt	p.S119I		NM_175858.2	NP_787054.1	Q8IUC1	KR111_HUMAN	keratin associated protein 11-1	119	4 X 10 AA approximate repeats.					keratin filament	structural molecule activity			breast(1)|cervix(1)|endometrium(1)|large_intestine(2)|lung(12)|pancreas(1)	18						TTGGCAGACACTGGAGATGCC	0.577000													6	44					8.12818e-05	0.000116174	0.029380	1	0
QRFPR	84109	broad.mit.edu	37	4	122250793	122250793	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr4:122250793G>T	ENST00000394427.2	-	6	1383	c.972C>A	c.(970-972)aaC>aaA	p.N324K	QRFPR_ENST00000334383.5_3'UTR	NM_198179.2	NP_937822.2	Q96P65	QRFPR_HUMAN	pyroglutamylated RFamide peptide receptor	324						plasma membrane	neuropeptide Y receptor activity			endometrium(1)|kidney(2)|large_intestine(9)|lung(10)|prostate(2)|skin(3)|stomach(1)	28						TACAGATGGAGTTGGAAAATC	0.284000													3	40					0.004672	0.0056566	0.115264	1	0
ZP4	57829	broad.mit.edu	37	1	238053264	238053264	+	Silent	SNP	G	G	T			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr1:238053264G>T	ENST00000366570.4	-	3	461	c.303C>A	c.(301-303)tcC>tcA	p.S101S	RP11-193H5.1_ENST00000450451.1_RNA	NM_021186.3	NP_067009.1	Q12836	ZP4_HUMAN	zona pellucida glycoprotein 4	101					acrosomal vesicle exocytosis|negative regulation of binding of sperm to zona pellucida|positive regulation of acrosome reaction|positive regulation of humoral immune response|positive regulation of protein kinase activity|positive regulation of T cell proliferation|protein kinase A signaling cascade|protein kinase C signaling cascade	integral to membrane|intracellular|plasma membrane|proteinaceous extracellular matrix	acrosin binding|receptor activity			breast(6)|cervix(2)|endometrium(5)|kidney(2)|large_intestine(8)|lung(42)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	73	Ovarian(103;0.103)	all_cancers(173;0.00175)|all_epithelial(177;0.162)|all_neural(198;0.164)|Melanoma(53;0.211)|Prostate(94;0.214)	OV - Ovarian serous cystadenocarcinoma(106;0.00989)			TGATGTAGTGGGAGTCCTGGA	0.557000													13	282					6.72482e-11	1.20882e-10	0.132662	1	0
LINC01128	643837	broad.mit.edu	37	1	771837	771838	+	RNA	INS	-	-	C			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr1:771837_771838insC	ENST00000445118.2	+	0	270					NR_047519.1|NR_047520.1|NR_047521.1|NR_047522.1|NR_047523.1|NR_047524.1|NR_047525.1																						gcactgcagtgcccccccagcc	0.609													2	4	---	---	---	---					
LINC01135	100131060	broad.mit.edu	37	1	59316688	59316689	+	RNA	INS	-	-	A	rs151137060	byFrequency	TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr1:59316688_59316689insA	ENST00000419531.2	+	0	146				RP11-63G10.2_ENST00000424592.1_lincRNA	NR_034014.1																						TTTTTTTTTTTAAAGCATCCTT	0.307													2	4	---	---	---	---					
GNG12-AS1	100289178	broad.mit.edu	37	1	68466491	68466492	+	RNA	INS	-	-	T	rs75908389	by1000genomes	TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr1:68466491_68466492insT	ENST00000420587.1	+	0	134				GNG12-AS1_ENST00000413628.1_RNA|GNG12-AS1_ENST00000414904.1_RNA	NR_040077.1		Q6ZVV5	Q6ZVV5_HUMAN																			tgtgtagctccctctctccctc	0.431													6	6	---	---	---	---					
RP11-424D14.1	0	broad.mit.edu	37	1	69534707	69534707	+	RNA	DEL	T	T	-			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr1:69534707delT	ENST00000425517.1	+	0	150																											atcttagttattttttgtctt	0.308													2	4	---	---	---	---					
RP11-424D14.1	0	broad.mit.edu	37	1	69617085	69617085	+	RNA	DEL	A	A	-			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr1:69617085delA	ENST00000425517.1	+	0	317																											gtcataactgaaaaaaaaaag	0.234													2	4	---	---	---	---					
RP4-788P17.1	0	broad.mit.edu	37	1	74144310	74144310	+	RNA	DEL	G	G	-			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr1:74144310delG	ENST00000424953.1	+	0	26																											ctggagttctggtgggtagta	0.388													2	4	---	---	---	---					
LINC01362	103283057	broad.mit.edu	37	1	83519520	83519520	+	RNA	DEL	G	G	-			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr1:83519520delG	ENST00000452901.1	+	0	1056																											CAAAGCTTCAGGATGATCAAA	0.353													2	4	---	---	---	---					
LINC01362	103283057	broad.mit.edu	37	1	83586786	83586789	+	RNA	DEL	TTTA	TTTA	-			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr1:83586786_83586789delTTTA	ENST00000452901.1	+	0	1539																											ggtttttggttttatttatttatt	0.314													2	4	---	---	---	---					
LOC101927587	101927587	broad.mit.edu	37	1	84186085	84186086	+	RNA	DEL	TT	TT	-	rs149358100		TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr1:84186085_84186086delTT	ENST00000417975.1	-	0	280																											ataggtgtactttttttttttt	0.366													3	4	---	---	---	---					
PKN2-AS1	101927891	broad.mit.edu	37	1	89149199	89149200	+	RNA	INS	-	-	A			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr1:89149199_89149200insA	ENST00000458097.1	-	0	41																											TAAAACAACCCAAAAAAACCCA	0.426													2	4	---	---	---	---					
LINC01057	101928079	broad.mit.edu	37	1	95196342	95196342	+	RNA	DEL	T	T	-			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr1:95196342delT	ENST00000452922.1	-	0	506																											TGAGTTTCCCTTTCCTCCAAC	0.567													2	4	---	---	---	---					
LOC729987	729987	broad.mit.edu	37	1	98677137	98677138	+	RNA	INS	-	-	T			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr1:98677137_98677138insT	ENST00000418344.1	+	0	64					NR_046088.1																						tctattggtcatttttttccct	0.455													2	4	---	---	---	---					
RP11-233E12.1	0	broad.mit.edu	37	1	107364820	107364821	+	RNA	INS	-	-	T			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr1:107364820_107364821insT	ENST00000415910.2	+	0	660																											aatgctaaaaattttttcttgt	0.262													2	4	---	---	---	---					
RP11-88H9.2	0	broad.mit.edu	37	1	112536467	112536467	+	RNA	DEL	G	G	-			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr1:112536467delG	ENST00000438293.1	+	0	652																											TCACCTCGATGGGCCCGCAGG	0.488													2	4	---	---	---	---					
RP4-543J13.1	0	broad.mit.edu	37	1	114763057	114763057	+	RNA	DEL	T	T	-			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr1:114763057delT	ENST00000420156.2	-	0	73																											tacatcaaacttaatagccgt	0.239													2	4	---	---	---	---					
RP4-663N10.1	0	broad.mit.edu	37	1	115898210	115898211	+	RNA	INS	-	-	TT	rs71582523		TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr1:115898210_115898211insTT	ENST00000425449.1	+	0	207																											GGAtctctctctctctctctct	0.436													2	4	---	---	---	---					
LINC01525	104355292	broad.mit.edu	37	1	117863214	117863215	+	RNA	INS	-	-	T			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr1:117863214_117863215insT	ENST00000442182.1	+	0	298																											GGACCCAAACCTTTTTGTTTCT	0.421													2	4	---	---	---	---					
SRGAP2-AS1	100873165	broad.mit.edu	37	1	121140484	121140485	+	RNA	DEL	AA	AA	-	rs77501191		TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr1:121140484_121140485delAA	ENST00000417218.1	+	0	551																											tgatggggttaaaaaaaaaaaa	0.446													3	5	---	---	---	---					
RP11-782C8.2	0	broad.mit.edu	37	1	143147311	143147311	+	RNA	DEL	T	T	-	rs72338349		TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr1:143147311delT	ENST00000412204.2	-	0	2503				RP11-782C8.1_ENST00000438000.1_lincRNA																							aatttttgtattttttttttt	0.458													2	4	---	---	---	---					
RP11-782C8.2	0	broad.mit.edu	37	1	143161518	143161519	+	RNA	INS	-	-	C	rs78859366		TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr1:143161518_143161519insC	ENST00000412204.2	-	0	2503				RP11-782C8.4_ENST00000424474.2_lincRNA|RP11-782C8.1_ENST00000438000.1_lincRNA																							ttaaagtataattaaaaaaaag	0.337													3	5	---	---	---	---					
LOC101927648	101927648	broad.mit.edu	37	1	143425098	143425099	+	RNA	INS	-	-	A			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr1:143425098_143425099insA	ENST00000423249.1	-	0	59																											ccagtaatgctaaaaaccaacc	0.406													2	4	---	---	---	---					
SRGAP2B	647135	broad.mit.edu	37	1	143992245	143992245	+	RNA	DEL	A	A	-			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr1:143992245delA	ENST00000467933.1	+	0	915																											aaaaaaaaacaaaaaaaaaaa	0.398													2	4	---	---	---	---					
FLG-AS1	339400	broad.mit.edu	37	1	152204663	152204664	+	RNA	INS	-	-	A			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr1:152204663_152204664insA	ENST00000420707.1	+	0	158				FLG-AS1_ENST00000593011.1_RNA																							actatttattgaaaaagatatt	0.322													2	4	---	---	---	---					
RP1-91G5.3	0	broad.mit.edu	37	1	152356147	152356147	+	RNA	DEL	T	T	-	rs35242055		TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr1:152356147delT	ENST00000411804.1	+	0	94																											cgtctgtatgttttttttttt	0.274													4	2	---	---	---	---					
RP1-79C4.1	0	broad.mit.edu	37	1	170598837	170598837	+	RNA	DEL	C	C	-	rs537109	by1000genomes	TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr1:170598837delC	ENST00000413005.1	+	0	162																											tgaggattttcgcatcaatgt	0.398													3	3	---	---	---	---					
RP1-15D23.2	0	broad.mit.edu	37	1	172751362	172751363	+	RNA	INS	-	-	T			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr1:172751362_172751363insT	ENST00000432694.1	+	0	223																											ggatgtcatcctttttttatgg	0.347													2	4	---	---	---	---					
LINC01344	400799	broad.mit.edu	37	1	182192500	182192500	+	RNA	DEL	C	C	-			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr1:182192500delC	ENST00000449842.1	-	0	410																											gttctgtccacggcaatcagg	0.403													4	8	---	---	---	---					
LINC01350	101929093	broad.mit.edu	37	1	185580116	185580117	+	RNA	INS	-	-	A	rs71810047		TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr1:185580116_185580117insA	ENST00000436955.1	-	0	424																											TTAGATTATTGAAAAAAAAAAA	0.307													2	4	---	---	---	---					
LINC01036	104169671	broad.mit.edu	37	1	187146233	187146234	+	RNA	INS	-	-	TG	rs57592159	by1000genomes	TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr1:187146233_187146234insTG	ENST00000458683.1	+	0	105																											ttttcacgtattggtAGGtgta	0.322													4	3	---	---	---	---					
RP11-541F9.2	0	broad.mit.edu	37	1	191865205	191865205	+	RNA	DEL	A	A	-	rs71787251		TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr1:191865205delA	ENST00000430776.1	+	0	206																											caagaaaaagaaaaaaaaagt	0.303													7	1	---	---	---	---					
RP11-739N20.2	0	broad.mit.edu	37	1	204369477	204369477	+	RNA	DEL	A	A	-	rs2942129	by1000genomes	TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr1:204369477delA	ENST00000443515.1	+	0	146																											CATCttttttattttcaacat	0.408													3	6	---	---	---	---					
RP11-354K1.2	0	broad.mit.edu	37	1	211811089	211811090	+	RNA	INS	-	-	T	rs141131357		TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr1:211811089_211811090insT	ENST00000452024.2	-	0	45																											ttttttctttcttttttttttt	0.446													2	4	---	---	---	---					
RP11-323I1.1	0	broad.mit.edu	37	1	213929921	213929921	+	RNA	DEL	G	G	-			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr1:213929921delG	ENST00000456240.1	+	0	143																											atcacactttggtaatttttg	0.388													2	4	---	---	---	---					
RP11-400N13.1	0	broad.mit.edu	37	1	222356627	222356628	+	RNA	INS	-	-	A	rs71849793		TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr1:222356627_222356628insA	ENST00000416510.1	-	0	278																											ACATGATAGACAAAAAAAAAAA	0.327													3	3	---	---	---	---					
AC099344.2	0	broad.mit.edu	37	2	11498377	11498379	+	RNA	DEL	TTG	TTG	-			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr2:11498377_11498379delTTG	ENST00000430897.1	-	0	539																											tcattgtgttttgttgttgttgt	0.414													2	4	---	---	---	---					
LOC100506457	100506457	broad.mit.edu	37	2	12290360	12290373	+	RNA	DEL	TGTGTGTGTGTGTG	TGTGTGTGTGTGTG	-	rs58795207		TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr2:12290360_12290373delTGTGTGTGTGTGTG	ENST00000412294.1	+	0	197																											TGTTGTTAACtgtgtgtgtgtgtgtgtgtgtgtg	0.393													3	4	---	---	---	---					
LOC100506457	100506457	broad.mit.edu	37	2	12329082	12329082	+	RNA	DEL	A	A	-	rs72302326		TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr2:12329082delA	ENST00000412294.1	+	0	315																											tatctctaccaaaaaaaaaaa	0.507													2	4	---	---	---	---					
LOC100506457	100506457	broad.mit.edu	37	2	12677940	12677941	+	RNA	INS	-	-	G			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr2:12677940_12677941insG	ENST00000412294.1	+	0	412																											CTGGAAGTGTTGGGGGGACCAA	0.416													2	4	---	---	---	---					
AC068490.2	0	broad.mit.edu	37	2	22328503	22328504	+	RNA	INS	-	-	AGGG			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr2:22328503_22328504insAGGG	ENST00000450551.1	-	0	200																											gggagggaggaagggagggagg	0.520													2	4	---	---	---	---					
SRD5A2	6716	broad.mit.edu	37	2	31794747	31794748	+	RNA	INS	-	-	A	rs59267261		TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr2:31794747_31794748insA	ENST00000405650.1	-	0	447							P31213	S5A2_HUMAN	steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2)						androgen biosynthetic process|cell differentiation|cell-cell signaling|male gonad development	endoplasmic reticulum membrane|integral to membrane|microsome	3-oxo-5-alpha-steroid 4-dehydrogenase activity|sterol 5-alpha reductase activity					Acute lymphoblastic leukemia(172;0.155)				Azelaic Acid(DB00548)|Dutasteride(DB01126)	aaacaaaaaacaaaaaaaaaaa	0.262													2	4	---	---	---	---					
AC073218.1	0	broad.mit.edu	37	2	34729546	34729546	+	RNA	DEL	T	T	-			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr2:34729546delT	ENST00000422558.1	+	0	475																											attgtctctgttttttggtga	0.353													2	4	---	---	---	---					
AC073218.1	0	broad.mit.edu	37	2	34821548	34821549	+	RNA	INS	-	-	C	rs67596429	by1000genomes	TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr2:34821548_34821549insC	ENST00000422558.1	+	0	475																											GTGATTTTATTTAAGCCTGACT	0.332													4	6	---	---	---	---					
AC009229.5	0	broad.mit.edu	37	2	38453405	38453406	+	RNA	INS	-	-	A			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr2:38453405_38453406insA	ENST00000450854.1	-	0	533																											ttcaagtattgaaaaaaaaaaa	0.312													3	5	---	---	---	---					
LOC728730	728730	broad.mit.edu	37	2	39787044	39787044	+	RNA	DEL	T	T	-			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr2:39787044delT	ENST00000449569.1	+	0	538				AC007246.3_ENST00000425775.1_RNA|AC007246.3_ENST00000446698.1_RNA|AC007246.3_ENST00000415640.1_RNA|AC007246.3_ENST00000438649.1_RNA|AC007246.3_ENST00000451547.1_RNA|AC007246.3_ENST00000426083.1_RNA|AC007246.3_ENST00000422128.1_RNA	NR_037875.1																						atctactctcttttttttttt	0.433													4	6	---	---	---	---					
SLC8A1-AS1	100128590	broad.mit.edu	37	2	40106410	40106410	+	RNA	DEL	A	A	-			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr2:40106410delA	ENST00000599740.1	+	0	73																											catcctcagcaaaaaaaaaag	0.423													2	4	---	---	---	---					
SLC8A1-AS1	100128590	broad.mit.edu	37	2	40230659	40230659	+	RNA	DEL	T	T	-	rs142996547		TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr2:40230659delT	ENST00000418854.1	+	0	132				SLC8A1-AS1_ENST00000599740.1_RNA																							CAAATATGACTTTTTTTTTTT	0.313													2	4	---	---	---	---					
LOC730100	730100	broad.mit.edu	37	2	51855044	51855045	+	RNA	DEL	TG	TG	-	rs72352043		TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr2:51855044_51855045delTG	ENST00000440698.1	+	0	753																											CAtgtgagtatgtgtgtgtgtg	0.307													4	4	---	---	---	---					
LINC01122	400955	broad.mit.edu	37	2	58741127	58741127	+	RNA	DEL	T	T	-			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr2:58741127delT	ENST00000452840.1	+	0	195																											TTAAGTAAAATTTTAGGTAAT	0.279													2	4	---	---	---	---					
AC010987.5	0	broad.mit.edu	37	2	67869601	67869602	+	RNA	DEL	CT	CT	-			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr2:67869601_67869602delCT	ENST00000419809.1	-	0	126																											GAAACTATCCCTGCACTCAAGG	0.312													2	4	---	---	---	---					
AC010105.1	0	broad.mit.edu	37	2	82738379	82738379	+	RNA	DEL	T	T	-			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr2:82738379delT	ENST00000437290.2	-	0	204																											AACTTGGTTGTTTTTTTTTTT	0.348													2	4	---	---	---	---					
AC019100.3	0	broad.mit.edu	37	2	108831922	108831923	+	RNA	DEL	AC	AC	-	rs35676430		TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr2:108831922_108831923delAC	ENST00000445083.1	-	0	147																											ACCACAGAATacacacacacac	0.297													7	1	---	---	---	---					
SLC4A10	57282	broad.mit.edu	37	2	162372341	162372341	+	RNA	DEL	A	A	-			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr2:162372341delA	ENST00000605990.1	+	0	344																											gtttccaattaaaaaaaaaaa	0.299													2	4	---	---	---	---					
AC092684.1	0	broad.mit.edu	37	2	164924634	164924635	+	RNA	INS	-	-	C			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr2:164924634_164924635insC	ENST00000429636.1	-	0	196																											GCAGGTTTTATCCCCCCCACTA	0.386													2	4	---	---	---	---					
AC092684.1	0	broad.mit.edu	37	2	165023637	165023637	+	RNA	DEL	T	T	-			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr2:165023637delT	ENST00000429636.1	-	0	196																											tttcttttgcttaggattgat	0.348													2	4	---	---	---	---					
AC092684.1	0	broad.mit.edu	37	2	165125638	165125639	+	RNA	INS	-	-	T			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr2:165125638_165125639insT	ENST00000429636.1	-	0	104																											cacaagctctcttttttgcctg	0.475													2	4	---	---	---	---					
AC009495.4	0	broad.mit.edu	37	2	166700178	166700179	+	RNA	INS	-	-	T	rs35922618		TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr2:166700178_166700179insT	ENST00000428888.1	-	0	139																											TTTTACCATGATTTTTTTTAGA	0.401													2	4	---	---	---	---					
AC079305.11	0	broad.mit.edu	37	2	177944048	177944049	+	RNA	INS	-	-	AT			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr2:177944048_177944049insAT	ENST00000441205.1	-	0	370																											TATAAGTATTAATATTTCAAAT	0.322													2	4	---	---	---	---					
AC007319.1	0	broad.mit.edu	37	2	188152054	188152055	+	RNA	DEL	TT	TT	-	rs3079450		TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr2:188152054_188152055delTT	ENST00000412276.1	+	0	189				AC007319.1_ENST00000453517.1_RNA																							AAAATGAAACTTTTCTCTTCTC	0.356													2	4	---	---	---	---					
AC079613.1	0	broad.mit.edu	37	2	189509913	189509914	+	RNA	DEL	GA	GA	-			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr2:189509913_189509914delGA	ENST00000431708.1	-	0	465																											GGAGAGGGATGAGAGAGAGAGA	0.351													2	4	---	---	---	---					
LINC00607	646324	broad.mit.edu	37	2	216630719	216630719	+	RNA	DEL	G	G	-			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr2:216630719delG	ENST00000445174.1	-	0	211					NR_037195.1																						AGGGCCCAGTGGGAGCTAGGG	0.493													2	4	---	---	---	---					
AC007563.5	0	broad.mit.edu	37	2	217695064	217695065	+	RNA	INS	-	-	G			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr2:217695064_217695065insG	ENST00000447289.1	+	0	510																											CAGCACTTAATGGGGGTTTCTG	0.347													2	4	---	---	---	---					
AC114765.1	0	broad.mit.edu	37	2	221074109	221074110	+	RNA	INS	-	-	T	rs60936976	by1000genomes	TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr2:221074109_221074110insT	ENST00000432993.1	+	0	306				AC114765.2_ENST00000438633.1_lincRNA																							CCTCTCCCCCCTTTTTTTTACA	0.396													2	4	---	---	---	---					
AC067956.1	0	broad.mit.edu	37	2	221335145	221335146	+	RNA	INS	-	-	C	rs67907879	by1000genomes	TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr2:221335145_221335146insC	ENST00000414512.1	+	0	368																											ttaatacaCTGCCACCCCAGCA	0.396													3	2	---	---	---	---					
LOC151484	151484	broad.mit.edu	37	2	231756977	231756978	+	RNA	INS	-	-	A	rs35067285	by1000genomes	TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr2:231756977_231756978insA	ENST00000415628.1	+	0	424				AC012507.3_ENST00000447074.1_RNA|AC012507.3_ENST00000455128.1_RNA	NR_038238.1																						gactccatctcaaaaaaaaaga	0.470													4	3	---	---	---	---					
SATB1-AS1	101927777	broad.mit.edu	37	3	18533339	18533339	+	RNA	DEL	T	T	-			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr3:18533339delT	ENST00000593741.1	+	0	234				AC144521.1_ENST00000598498.1_RNA|AC144521.1_ENST00000598740.1_RNA|AC144521.1_ENST00000596277.1_RNA|AC144521.1_ENST00000596850.1_RNA|AC144521.1_ENST00000593444.1_RNA|AC144521.1_ENST00000595388.1_RNA|AC144521.1_ENST00000595865.1_RNA|AC144521.1_ENST00000595250.1_RNA|AC144521.1_ENST00000598390.1_RNA|AC144521.1_ENST00000598688.1_RNA|AC144521.1_ENST00000456253.2_RNA|AC144521.1_ENST00000414198.1_RNA|AC144521.1_ENST00000596307.1_RNA|AC144521.1_ENST00000599762.1_RNA																							tatctccaacttttttttttt	0.448													3	4	---	---	---	---					
SATB1-AS1	101927777	broad.mit.edu	37	3	18744932	18744932	+	RNA	DEL	G	G	-			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr3:18744932delG	ENST00000595388.1	+	0	364				AC144521.1_ENST00000425799.2_RNA																							actactaagtgggctcttggg	0.483													2	4	---	---	---	---					
SATB1-AS1	101927777	broad.mit.edu	37	3	18750864	18750865	+	RNA	INS	-	-	T			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr3:18750864_18750865insT	ENST00000595388.1	+	0	364				AC144521.1_ENST00000425799.2_RNA																							CTAATACAGCATTTTTTCCTGT	0.421													2	4	---	---	---	---					
SATB1-AS1	101927777	broad.mit.edu	37	3	18940879	18940880	+	RNA	DEL	AC	AC	-			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr3:18940879_18940880delAC	ENST00000425799.2	+	0	463																											CCACCAGAAAacacacacacac	0.371													2	4	---	---	---	---					
AC133680.1	0	broad.mit.edu	37	3	25004909	25004911	+	RNA	DEL	TTG	TTG	-	rs34215998		TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr3:25004909_25004911delTTG	ENST00000455576.1	+	0	345																											CTTCCCATCCTTGTTGTCACGCT	0.448													3	4	---	---	---	---					
RP11-875H7.1	0	broad.mit.edu	37	3	55378764	55378765	+	RNA	DEL	GA	GA	-			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr3:55378764_55378765delGA	ENST00000469806.1	-	0	61																											ATGTGTGTGTGAGAGAGAGAGA	0.500													3	4	---	---	---	---					
SUCLG2-AS1	101927111	broad.mit.edu	37	3	67785391	67785392	+	RNA	INS	-	-	G			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr3:67785391_67785392insG	ENST00000482677.1	+	0	615																											acagcgagtgaggggggaactg	0.510													2	4	---	---	---	---					
RP11-20B7.1	0	broad.mit.edu	37	3	73898562	73898562	+	RNA	DEL	A	A	-			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr3:73898562delA	ENST00000498832.1	+	0	68																											CTCTTTGGCTAAGAAGCATCA	0.383													2	4	---	---	---	---					
LOC728290	728290	broad.mit.edu	37	3	81044810	81044811	+	RNA	DEL	AC	AC	-	rs72402064		TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr3:81044810_81044811delAC	ENST00000482617.1	+	0	60																											acatttgcatacacacacacac	0.381													2	4	---	---	---	---					
RP11-260O18.1	0	broad.mit.edu	37	3	82064514	82064515	+	RNA	INS	-	-	T			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr3:82064514_82064515insT	ENST00000470263.1	+	0	244																											aactaaataacttttttttttt	0.431													2	4	---	---	---	---					
RP11-260O18.1	0	broad.mit.edu	37	3	82079051	82079051	+	RNA	DEL	A	A	-	rs111324730		TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr3:82079051delA	ENST00000470263.1	+	0	244																											GGACTGAGTTAAAAAAAAAAA	0.333													3	3	---	---	---	---					
RP11-325B23.2	0	broad.mit.edu	37	3	98143771	98143771	+	RNA	DEL	T	T	-			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr3:98143771delT	ENST00000508616.1	+	0	188																											tactatgtacttttttttgca	0.313													2	4	---	---	---	---					
RP11-457K10.1	0	broad.mit.edu	37	3	109457733	109457733	+	RNA	DEL	A	A	-			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr3:109457733delA	ENST00000485384.1	+	0	29																											cacagcaaagaaaacaatcaa	0.299													2	4	---	---	---	---					
RP11-23D24.2	0	broad.mit.edu	37	3	153279747	153279748	+	RNA	INS	-	-	A			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr3:153279747_153279748insA	ENST00000493214.2	-	0	260																											cctcccttgcccaaggcttctg	0.441													2	4	---	---	---	---					
RP11-379F4.4	0	broad.mit.edu	37	3	158461808	158461808	+	RNA	DEL	G	G	-			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr3:158461808delG	ENST00000468242.1	+	0	431				RP11-379F4.4_ENST00000465477.1_RNA																							TTGATTCCTTGGAGTgttctt	0.418													2	4	---	---	---	---					
RP11-324C10.1	0	broad.mit.edu	37	3	172962606	172962607	+	RNA	DEL	CC	CC	-	rs59435157		TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr3:172962606_172962607delCC	ENST00000447709.1	+	0	22																											ttatccctcacccccccccacc	0.450													5	2	---	---	---	---					
LINCR-0002	103344926	broad.mit.edu	37	3	191278959	191278960	+	RNA	INS	-	-	C			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr3:191278959_191278960insC	ENST00000439804.1	+	0	61																											ggggaaaactgcccccatgatc	0.441													2	4	---	---	---	---					
SDHAP1	255812	broad.mit.edu	37	3	195691295	195691296	+	RNA	INS	-	-	A			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr3:195691295_195691296insA	ENST00000427841.1	-	0	2203					NR_003264.2																						aaaaacaaaacaaaaaaCCTGA	0.431													2	4	---	---	---	---					
RP11-281P23.2	0	broad.mit.edu	37	4	11758117	11758117	+	RNA	DEL	T	T	-			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr4:11758117delT	ENST00000509244.1	+	0	121				RP11-74M11.2_ENST00000506195.1_lincRNA																							AGGGAGCTTCTTAGCACTTCA	0.438													2	4	---	---	---	---					
LINC01182	101929071	broad.mit.edu	37	4	13763788	13763789	+	RNA	DEL	TG	TG	-	rs34876962		TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr4:13763788_13763789delTG	ENST00000510907.1	+	0	281																											ggagagggGCTGTTTTTTTTTT	0.460													4	3	---	---	---	---					
RP11-669M16.1	0	broad.mit.edu	37	4	14241072	14241073	+	RNA	INS	-	-	A			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr4:14241072_14241073insA	ENST00000505628.1	+	0	332																											ttatatagttgaaaaaaagaat	0.287													2	4	---	---	---	---					
LINC00504	201853	broad.mit.edu	37	4	14550948	14550948	+	RNA	DEL	A	A	-			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr4:14550948delA	ENST00000505089.1	-	0	461																											actattgtggaagacagcata	0.373													2	4	---	---	---	---					
RP11-3J1.1	0	broad.mit.edu	37	4	19301050	19301050	+	RNA	DEL	T	T	-			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr4:19301050delT	ENST00000505347.1	-	0	449																											AGAATGTAAATTTGTGAAGTA	0.333													2	4	---	---	---	---					
RP11-3J1.1	0	broad.mit.edu	37	4	19328650	19328650	+	RNA	DEL	T	T	-	rs72257734		TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr4:19328650delT	ENST00000505347.1	-	0	449																											cactgcagcatttttttttaa	0.308													2	4	---	---	---	---					
RP11-608O21.1	0	broad.mit.edu	37	4	19631780	19631781	+	RNA	INS	-	-	C			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr4:19631780_19631781insC	ENST00000511431.1	+	0	288																											TGGAATTGCAACCCCCCCCTTA	0.366													3	6	---	---	---	---					
RP11-17E2.2	0	broad.mit.edu	37	4	22317858	22317858	+	RNA	DEL	A	A	-	rs35133982		TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr4:22317858delA	ENST00000510705.3	+	0	859																											ATCTTCATGGAATCATGGGAT	0.383													5	1	---	---	---	---					
LOC101928622	101928622	broad.mit.edu	37	4	33951379	33951379	+	RNA	DEL	T	T	-			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr4:33951379delT	ENST00000505018.1	-	0	307				RP11-79E3.2_ENST00000506650.1_lincRNA																							TGTTGACCAGttttttttttg	0.408													2	4	---	---	---	---					
LINC01258	101928776	broad.mit.edu	37	4	38460466	38460467	+	RNA	INS	-	-	C			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr4:38460466_38460467insC	ENST00000512517.1	-	0	184																											TGGTGACAGTTCCCCAGTAAGG	0.401													2	4	---	---	---	---					
RP11-506N2.1	0	broad.mit.edu	37	4	59839393	59839393	+	RNA	DEL	T	T	-			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr4:59839393delT	ENST00000513551.1	-	0	236																											ctctggcttgtttttgtaaac	0.413													2	4	---	---	---	---					
RP11-593F5.2	0	broad.mit.edu	37	4	61621523	61621524	+	RNA	INS	-	-	C	rs35500000	by1000genomes	TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr4:61621523_61621524insC	ENST00000509559.1	+	0	280																											aggagacttttcccgctacagc	0.460													2	4	---	---	---	---					
LOC101929468	101929468	broad.mit.edu	37	4	105460997	105460998	+	RNA	INS	-	-	T			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr4:105460997_105460998insT	ENST00000500179.1	+	0	96																											CAATCGTTCTCTTttttttttt	0.332													3	4	---	---	---	---					
SEC24B-AS1	100533182	broad.mit.edu	37	4	110284711	110284714	+	RNA	DEL	TGTG	TGTG	-	rs56943302		TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr4:110284711_110284714delTGTG	ENST00000499713.2	-	0	723				SEC24B-AS1_ENST00000505895.1_RNA																							tgtgtgtgtttgtgtgtgtgtgtg	0.431													2	4	---	---	---	---					
RP11-269F21.1	0	broad.mit.edu	37	4	112730172	112730172	+	RNA	DEL	C	C	-			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr4:112730172delC	ENST00000506068.1	+	0	83				RP11-269F21.2_ENST00000508010.1_lincRNA																							GACTGTTGGGCCACCAATTTC	0.463													2	4	---	---	---	---					
RP11-125O18.1	0	broad.mit.edu	37	4	128249359	128249359	+	RNA	DEL	T	T	-			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr4:128249359delT	ENST00000504050.1	-	0	368																											CTGGAAATTATTAAAGTCAAA	0.333													2	4	---	---	---	---					
RP11-422J15.1	0	broad.mit.edu	37	4	130705597	130705598	+	RNA	INS	-	-	C			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr4:130705597_130705598insC	ENST00000513875.1	+	0	119																											gattacaggtgccccccaccac	0.530													4	3	---	---	---	---					
RP13-578N3.3	0	broad.mit.edu	37	4	144708324	144708324	+	RNA	DEL	T	T	-			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr4:144708324delT	ENST00000499587.2	+	0	178																											caggtattcctttatagtaat	0.398													2	4	---	---	---	---					
RP11-789C1.2	0	broad.mit.edu	37	4	171292949	171292949	+	RNA	DEL	C	C	-			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr4:171292949delC	ENST00000509548.2	+	0	127																											AAAAAGTCTTCCCCTCTATGC	0.448													2	4	---	---	---	---					
RP11-326I11.4	0	broad.mit.edu	37	4	185428750	185428750	+	RNA	DEL	G	G	-			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr4:185428750delG	ENST00000605270.1	-	0	142																											ttgggaggccgaggcgagcaa	0.512													2	4	---	---	---	---					
LINC01511	100506791	broad.mit.edu	37	5	1374222	1374223	+	RNA	INS	-	-	A	rs70957362	by1000genomes	TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr5:1374222_1374223insA	ENST00000504989.1	-	0	506																											cccatctctacaaaaaaaaaac	0.480													2	4	---	---	---	---					
LINC01019	285577	broad.mit.edu	37	5	3488771	3488772	+	RNA	INS	-	-	CTCC	rs141227539	by1000genomes	TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr5:3488771_3488772insCTCC	ENST00000505443.1	-	0	459					NR_033898.1																						tctgtctctctctgtctctctc	0.540													5	3	---	---	---	---					
FLJ33360	401172	broad.mit.edu	37	5	6321644	6321644	+	RNA	DEL	G	G	-			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr5:6321644delG	ENST00000507444.1	-	0	143					NR_028351.1																						GGGGGAAGGTGGAGGAAAGGC	0.443													2	4	---	---	---	---					
RP11-122F24.1	0	broad.mit.edu	37	5	7161637	7161638	+	RNA	INS	-	-	TTTT	rs149635813	by1000genomes	TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr5:7161637_7161638insTTTT	ENST00000512838.1	+	0	426																											attcctttgcgtttctctaatc	0.332													3	3	---	---	---	---					
LOC401177	401177	broad.mit.edu	37	5	17386745	17386745	+	RNA	DEL	G	G	-			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr5:17386745delG	ENST00000505158.1	-	0	109					NR_033975.1																						ctagcacattggggaggccaa	0.483													2	4	---	---	---	---					
GUSBP1	728411	broad.mit.edu	37	5	21534245	21534246	+	RNA	INS	-	-	TG	rs143137704		TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr5:21534245_21534246insTG	ENST00000607545.1	+	0	314					NR_027026.1																						GCAGGTGTGTCTGTCACAAACA	0.520													4	7	---	---	---	---					
GUSBP1	728411	broad.mit.edu	37	5	21553184	21553184	+	RNA	DEL	A	A	-			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr5:21553184delA	ENST00000607545.1	+	0	314					NR_027026.1																						attcacagatatttttctgaa	0.269													5	4	---	---	---	---					
CTD-2134P3.1	0	broad.mit.edu	37	5	28807520	28807520	+	RNA	DEL	A	A	-			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr5:28807520delA	ENST00000504398.1	-	0	294																											ACTCACAGTgaaaaatagtag	0.378													2	4	---	---	---	---					
CDH6	1004	broad.mit.edu	37	5	31323011	31323011	+	Frame_Shift_Del	DEL	G	G	-			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr5:31323011delG	ENST00000265071.2	+	12	2234	c.1969delG	c.(1969-1971)tcfs	p.V657fs		NM_004932.3	NP_004923.1	P55285	CADH6_HUMAN	cadherin 6, type 2, K-cadherin (fetal kidney)	657					adherens junction organization|cell junction assembly|homophilic cell adhesion	cytoplasm|integral to membrane|nucleus|plasma membrane	calcium ion binding			NS(3)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(42)|ovary(4)|prostate(6)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(1)	77						AGATAACATTGTCAGTTACAA	0.478													8	84	---	---	---	---					
CTD-2194L12.3	0	broad.mit.edu	37	5	37940476	37940477	+	RNA	DEL	TG	TG	-			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr5:37940476_37940477delTG	ENST00000510938.1	-	0	137																											gcagcctgtctgtttcatagag	0.475													2	4	---	---	---	---					
CTC-436P18.1	101928630	broad.mit.edu	37	5	60514999	60514999	+	RNA	DEL	T	T	-	rs79478841		TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr5:60514999delT	ENST00000506902.1	+	0	668																											CAGGTATTTGTTTTTTACAAT	0.353													2	4	---	---	---	---					
CTC-340D7.1	0	broad.mit.edu	37	5	68145719	68145719	+	RNA	DEL	A	A	-			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr5:68145719delA	ENST00000503268.1	-	0	377																		p.0?(1)									TATTCTAATTAAAGCTTACAA	0.289													2	4	---	---	---	---					
CTD-2292M14.1	0	broad.mit.edu	37	5	73384561	73384561	+	RNA	DEL	T	T	-	rs60257286		TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr5:73384561delT	ENST00000511395.1	-	0	477																											TTGTCTCTGATTTTTTTTTTT	0.368													4	3	---	---	---	---					
CTD-2503O16.4	0	broad.mit.edu	37	5	74236417	74236417	+	RNA	DEL	G	G	-			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr5:74236417delG	ENST00000505200.1	-	0	335																											ggctgggagcggggtggatga	0.413													2	4	---	---	---	---					
TMEM161B-AS1	100505894	broad.mit.edu	37	5	87689215	87689215	+	RNA	DEL	T	T	-			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr5:87689215delT	ENST00000501715.2	+	0	577				TMEM161B-AS1_ENST00000508015.1_RNA|TMEM161B-AS1_ENST00000510087.1_RNA|TMEM161B-AS1_ENST00000504922.1_RNA|TMEM161B-AS1_ENST00000501869.2_RNA																							GGGTTTTTCCTTTTTTTTCTT	0.348													3	4	---	---	---	---					
RP11-254I22.1	0	broad.mit.edu	37	5	95387652	95387653	+	RNA	INS	-	-	T			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr5:95387652_95387653insT	ENST00000507997.1	+	0	87				CTD-2337A12.1_ENST00000502645.2_RNA|CTD-2337A12.1_ENST00000511775.1_RNA																							gtacaataccatttttttaaca	0.361													2	4	---	---	---	---					
CTB-118N6.2	0	broad.mit.edu	37	5	115914944	115914945	+	RNA	INS	-	-	T	rs139143216	by1000genomes	TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr5:115914944_115914945insT	ENST00000508766.1	+	0	58																											gctcctctatctttggtcaaca	0.406													4	2	---	---	---	---					
LOC101927460	101927460	broad.mit.edu	37	5	124861743	124861745	+	RNA	DEL	AAC	AAC	-	rs74687096		TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr5:124861743_124861745delAAC	ENST00000564199.1	+	0	324																											tatcactgaaaacaaaatcaaaa	0.281													5	2	---	---	---	---					
CTD-2050E21.1	0	broad.mit.edu	37	5	142884289	142884291	+	RNA	DEL	ATC	ATC	-	rs10611481	by1000genomes	TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr5:142884289_142884291delATC	ENST00000340585.6	-	0	437																											gccttctcttatcatcatatatc	0.320													2	4	---	---	---	---					
LOC101927115	101927115	broad.mit.edu	37	5	151349480	151349480	+	RNA	DEL	G	G	-			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr5:151349480delG	ENST00000524295.1	+	0	199																											GGTTGCTCAAGGAGGACTACA	0.398													2	4	---	---	---	---					
RP11-32D16.1	0	broad.mit.edu	37	5	157921609	157921609	+	RNA	DEL	T	T	-			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr5:157921609delT	ENST00000522704.1	+	0	185																											actctgtaaattttttttgga	0.408													2	4	---	---	---	---					
CTB-11I22.1	0	broad.mit.edu	37	5	158644321	158644322	+	RNA	INS	-	-	C	rs143588247	by1000genomes	TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr5:158644321_158644322insC	ENST00000521204.1	+	0	191																											agagtctctgaccccaagacct	0.450													3	6	---	---	---	---					
LOC101927766	101927766	broad.mit.edu	37	5	159240961	159240962	+	RNA	INS	-	-	ATCAGTCAAC			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr5:159240961_159240962insATCAGTCAAC	ENST00000522627.1	-	0	3691																											caccaccccttatcagtcaaca	0.416													2	4	---	---	---	---					
RP11-779O18.3	0	broad.mit.edu	37	5	172190808	172190808	+	RNA	DEL	T	T	-			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr5:172190808delT	ENST00000523005.1	+	0	69																											AAAGTGTCTATTTCCTTCCCA	0.537													2	4	---	---	---	---					
RP11-536N17.1	0	broad.mit.edu	37	5	172244749	172244749	+	RNA	DEL	A	A	-	rs35920486		TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr5:172244749delA	ENST00000518260.1	+	0	105																											actctgcctcaaaaaaaaaaa	0.468													3	3	---	---	---	---					
LINC01411	101928176	broad.mit.edu	37	5	173820984	173820984	+	RNA	DEL	A	A	-			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr5:173820984delA	ENST00000510234.1	+	0	82																											GATTTTAGGGAAAAAAAAGTG	0.507													2	4	---	---	---	---					
SSR1	6745	broad.mit.edu	37	6	7290123	7290128	+	In_Frame_Del	DEL	TCTGTG	TCTGTG	-	rs138203075		TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr6:7290123_7290128delTCTGTG	ENST00000244763.4	-	8	916_921	c.830_835delCACAGA	c.(829-837)gag>g	p.AQK277del	SSR1_ENST00000397511.2_In_Frame_Del_p.AQK282del|SSR1_ENST00000489567.1_In_Frame_Del_p.AQK209del|RP11-69L16.4_ENST00000379928.4_RNA|SSR1_ENST00000474597.1_In_Frame_Del_p.AQK282del|SSR1_ENST00000534851.1_In_Frame_Del_p.AQK250del|SSR1_ENST00000479365.1_3'UTR	NM_003144.3	NP_003135.2	P43307	SSRA_HUMAN	signal sequence receptor, alpha	277					cotranslational protein targeting to membrane|positive regulation of cell proliferation	endoplasmic reticulum membrane|integral to membrane	signal sequence binding			NS(1)|endometrium(2)|large_intestine(3)|lung(2)|prostate(1)	9	Ovarian(93;0.0398)					ACTGATCTCTTCTGTGCCCGTTTCCT	0.388													8	97	---	---	---	---					
HCP5	10866	broad.mit.edu	37	6	31409184	31409185	+	RNA	INS	-	-	ACA	rs67294203		TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr6:31409184_31409185insACA	ENST00000414046.2	+	0	62					NR_040662.1		Q6MZN7	HCP5_HUMAN							defense response					urinary_tract(1)	1						CTTTCAAAAGCGCCAGAGACAT	0.426													3	3	---	---	---	---					
UFL1-AS1	100861530	broad.mit.edu	37	6	96866458	96866459	+	RNA	INS	-	-	A			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr6:96866458_96866459insA	ENST00000430796.1	-	0	110																											accttcttaatatctctccaat	0.416													2	4	---	---	---	---					
RP11-624M8.1	0	broad.mit.edu	37	6	125993732	125993733	+	RNA	INS	-	-	T	rs147916102		TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr6:125993732_125993733insT	ENST00000451660.2	-	0	443				RP11-624M8.1_ENST00000427852.2_RNA|RP11-624M8.1_ENST00000606334.1_RNA																							gatactaagccttttttttttt	0.421													2	4	---	---	---	---					
LOC100507477	100507477	broad.mit.edu	37	6	140403358	140403358	+	RNA	DEL	T	T	-			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr6:140403358delT	ENST00000456896.1	+	0	446																											GCAGTCTTTGTTTATCAGGAT	0.343													2	4	---	---	---	---					
RP1-292B18.4	0	broad.mit.edu	37	6	151464020	151464021	+	RNA	INS	-	-	G			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr6:151464020_151464021insG	ENST00000415477.1	-	0	316																											AGGTAGGAGGAGGGGGGCATAG	0.554													2	4	---	---	---	---					
AC004538.3	0	broad.mit.edu	37	7	11288021	11288022	+	RNA	DEL	TG	TG	-	rs35195239		TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr7:11288021_11288022delTG	ENST00000599875.1	+	0	186				AC004538.3_ENST00000441110.1_RNA|AC004538.3_ENST00000428967.1_RNA																							TACTGATCTCtgtgtgtgtgtg	0.426													3	3	---	---	---	---					
AC007255.8	0	broad.mit.edu	37	7	29587956	29587956	+	RNA	DEL	T	T	-			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr7:29587956delT	ENST00000447171.1	-	0	340																											CACATATGACTTAACATTATT	0.284													2	4	---	---	---	---					
AC023669.1	0	broad.mit.edu	37	7	46306171	46306171	+	RNA	DEL	A	A	-			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr7:46306171delA	ENST00000414915.1	+	0	226																											tttgagatggagacacactct	0.473													2	4	---	---	---	---					
LINC01446	401337	broad.mit.edu	37	7	53736001	53736002	+	RNA	INS	-	-	T			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr7:53736001_53736002insT	ENST00000380970.2	-	0	1544					NR_038371.1																						tgcctttccagttttttgatag	0.297													3	3	---	---	---	---					
RP13-492C18.2	0	broad.mit.edu	37	7	56504976	56504977	+	RNA	DEL	AG	AG	-			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr7:56504976_56504977delAG	ENST00000443198.1	-	0	157																											agctcagcacagagagagagag	0.485													2	4	---	---	---	---					
GS1-124K5.11	0	broad.mit.edu	37	7	65997351	65997352	+	RNA	INS	-	-	T			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr7:65997351_65997352insT	ENST00000449307.2	-	0	1308																											GGGGTCGGGCAttttttttttt	0.480													3	3	---	---	---	---					
AC003988.1	0	broad.mit.edu	37	7	79896304	79896304	+	RNA	DEL	C	C	-			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr7:79896304delC	ENST00000447198.2	-	0	202																											TTAGAATCAGCCATGTAACAG	0.328													3	3	---	---	---	---					
RP11-736E3.1	0	broad.mit.edu	37	7	112776433	112776434	+	RNA	DEL	TG	TG	-			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr7:112776433_112776434delTG	ENST00000441928.1	+	0	273																											tgtgtgtgtatgtgtgtgtgtg	0.337													3	3	---	---	---	---					
RP11-458K10.1	0	broad.mit.edu	37	7	115315931	115315931	+	RNA	DEL	G	G	-			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr7:115315931delG	ENST00000471672.1	-	0	210																											TCTTCGGTTTGCACACTATTA	0.348													2	4	---	---	---	---					
RP11-328J2.1	0	broad.mit.edu	37	7	119510186	119510187	+	RNA	INS	-	-	T			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr7:119510186_119510187insT	ENST00000426413.1	-	0	83																											tttgtagtttgttttttttttc	0.356													2	4	---	---	---	---					
RP5-921G16.1	0	broad.mit.edu	37	7	123779023	123779024	+	RNA	INS	-	-	G			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr7:123779023_123779024insG	ENST00000484322.1	+	0	168																											taagttttttttcttttgtttc	0.356													2	4	---	---	---	---					
AC009784.3	0	broad.mit.edu	37	7	136049862	136049862	+	RNA	DEL	T	T	-			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr7:136049862delT	ENST00000445293.2	+	0	730																											ctgatagaaatttaccttaga	0.284													2	4	---	---	---	---					
ERICH1-AS1	619343	broad.mit.edu	37	8	1058438	1058441	+	RNA	DEL	GTGA	GTGA	-			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr8:1058438_1058441delGTGA	ENST00000522092.1	+	0	332					NR_073397.1|NR_073466.1																						GCTGTGAGATGTGAGTGAGTGCAC	0.525													2	4	---	---	---	---					
FAM85B	619431	broad.mit.edu	37	8	8026018	8026019	+	RNA	INS	-	-	A			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr8:8026018_8026019insA	ENST00000519726.2	-	0	527																											aaaaaaaaaagaaaaaaaaaaa	0.446													3	5	---	---	---	---					
RP11-624C23.1	0	broad.mit.edu	37	8	24563209	24563209	+	RNA	DEL	A	A	-			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr8:24563209delA	ENST00000519689.1	-	0	184																											cagaaggttgaggatatagta	0.443													2	4	---	---	---	---					
RP11-94H18.2	0	broad.mit.edu	37	8	29728255	29728256	+	RNA	INS	-	-	G			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr8:29728255_29728256insG	ENST00000522967.1	+	0	55																											TGGAGAAGTCTGGGGGTGAGTC	0.465													3	3	---	---	---	---					
RP1-84O15.2	0	broad.mit.edu	37	8	34099820	34099821	+	RNA	DEL	GA	GA	-			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr8:34099820_34099821delGA	ENST00000522460.1	+	0	202				RP11-431M3.2_ENST00000518178.1_lincRNA																							aggagaggaggagagagagaAT	0.450													5	8	---	---	---	---					
LINC01288	103689844	broad.mit.edu	37	8	34678143	34678143	+	RNA	DEL	A	A	-	rs112822002		TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr8:34678143delA	ENST00000519189.1	+	0	387																											TAACCTGCTGAAAAAAAAAAG	0.343													2	4	---	---	---	---					
RP11-90P5.2	0	broad.mit.edu	37	8	38013175	38013175	+	RNA	DEL	T	T	-			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr8:38013175delT	ENST00000520598.1	+	0	99																											cttgttttacttttttttttt	0.398													2	4	---	---	---	---					
RP11-120I21.2	0	broad.mit.edu	37	8	84882876	84882878	+	RNA	DEL	ACC	ACC	-			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr8:84882876_84882878delACC	ENST00000523678.1	+	0	123																											caccaccacgaccaccaccacca	0.429													2	4	---	---	---	---					
LINC00535	642924	broad.mit.edu	37	8	94615039	94615039	+	RNA	DEL	A	A	-			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr8:94615039delA	ENST00000501400.1	-	0	948					NR_033858.1																						AAGACATTCCAAAAAAAGGAA	0.378													2	4	---	---	---	---					
C8orf37-AS1	100616530	broad.mit.edu	37	8	96338845	96338846	+	RNA	DEL	AA	AA	-	rs71273484		TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr8:96338845_96338846delAA	ENST00000521905.1	+	0	126																											actctatctcaaaaaaaaaaaa	0.460													3	4	---	---	---	---					
RP11-369K17.1	0	broad.mit.edu	37	8	122071081	122071087	+	RNA	DEL	AATAGAA	AATAGAA	-			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr8:122071081_122071087delAATAGAA	ENST00000517739.1	+	0	188																											ACTATTCAACAATAGAAAATGAACTAC	0.353													4	2	---	---	---	---					
RP11-89K10.1	0	broad.mit.edu	37	8	127682310	127682313	+	RNA	DEL	TGTG	TGTG	-			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr8:127682310_127682313delTGTG	ENST00000519880.1	+	0	156				RP11-89K10.1_ENST00000520512.1_RNA																							TGATTTATGAtgtgtgtgtgtgtg	0.392													3	3	---	---	---	---					
RP11-351C8.1	0	broad.mit.edu	37	8	127800288	127800288	+	RNA	DEL	T	T	-			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr8:127800288delT	ENST00000520224.1	-	0	70																											tttttaaggcttttttgcata	0.303													2	4	---	---	---	---					
CCDC26	137196	broad.mit.edu	37	8	130655978	130655978	+	RNA	DEL	T	T	-			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr8:130655978delT	ENST00000446592.3	-	0	312																											AAATCATACATGGAGCAACAG	0.393													7	2	---	---	---	---					
UBE2R2-AS1	101929665	broad.mit.edu	37	9	33802685	33802686	+	RNA	INS	-	-	A			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr9:33802685_33802686insA	ENST00000454429.2	-	0	169																											GGTAAAGTGGTATGATCTTCCA	0.455													2	4	---	---	---	---					
ATP8B5P	158381	broad.mit.edu	37	9	35409801	35409801	+	RNA	DEL	A	A	-			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr9:35409801delA	ENST00000430846.1	+	0	150																											actctatcttaaaaaaaaaaa	0.428													2	4	---	---	---	---					
RP11-764K9.1	0	broad.mit.edu	37	9	68406040	68406050	+	RNA	DEL	CCAAGGCAATC	CCAAGGCAATC	-			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr9:68406040_68406050delCCAAGGCAATC	ENST00000417843.2	-	0	224																											acctaagtagccaaggcaatcctaagcaaaa	0.365													2	4	---	---	---	---					
LOC101927502	101927502	broad.mit.edu	37	9	84387836	84387837	+	RNA	DEL	AG	AG	-	rs36083315		TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr9:84387836_84387837delAG	ENST00000437181.1	+	0	486																											ttttaataaaagagttatttaa	0.520													3	3	---	---	---	---					
AKR1C7P	648947	broad.mit.edu	37	10	5321280	5321281	+	RNA	INS	-	-	A	rs112001915		TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr10:5321280_5321281insA	ENST00000432689.2	-	0	399																											gactcagtctcaaaaaaaaaaa	0.411													2	4	---	---	---	---					
RP11-476F14.1	0	broad.mit.edu	37	10	33871867	33871868	+	RNA	INS	-	-	T	rs145607514		TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr10:33871867_33871868insT	ENST00000457848.1	-	0	423																											tcctcttcttgttttttttttt	0.396													4	4	---	---	---	---					
RP11-733D4.1	0	broad.mit.edu	37	10	45091949	45091949	+	RNA	DEL	A	A	-			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr10:45091949delA	ENST00000456722.1	-	0	155																											aatggaaagcaaaaaaaaaag	0.363													2	4	---	---	---	---					
RP11-170M17.1	0	broad.mit.edu	37	10	65696714	65696714	+	RNA	DEL	T	T	-			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr10:65696714delT	ENST00000444770.1	+	0	494																											TTTGGCAttcttttttttttt	0.403													3	4	---	---	---	---					
ZNF503	84858	broad.mit.edu	37	10	77052653	77052653	+	RNA	DEL	T	T	-			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr10:77052653delT	ENST00000418818.2	-	0	142																											GGCTTTGGTATTTTTTTCTTC	0.493													2	4	---	---	---	---					
LOC101926942	101926942	broad.mit.edu	37	10	92212774	92212774	+	RNA	DEL	A	A	-	rs35584710		TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr10:92212774delA	ENST00000418379.1	-	0	240																											ggtcttgaacacctaacctca	0.468													3	3	---	---	---	---					
WDR11-AS1	283089	broad.mit.edu	37	10	122573820	122573821	+	RNA	INS	-	-	T	rs140361614	by1000genomes	TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr10:122573820_122573821insT	ENST00000598981.1	-	0	228					NR_033850.1																						tttgtgacttgtacttttccta	0.297													4	4	---	---	---	---					
LOC101927708	101927708	broad.mit.edu	37	11	3593305	3593305	+	RNA	DEL	C	C	-			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr11:3593305delC	ENST00000527970.1	-	0	285																											TGTCCTGACTCtttttttttt	0.517													2	4	---	---	---	---					
LINC01495	102723378	broad.mit.edu	37	11	22474042	22474042	+	RNA	DEL	A	A	-	rs34022961		TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr11:22474042delA	ENST00000532380.1	-	0	341																											actcagtcttaaaaaaaaaaa	0.463													3	3	---	---	---	---					
RP11-960D24.1	0	broad.mit.edu	37	11	28701786	28701786	+	RNA	DEL	A	A	-			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr11:28701786delA	ENST00000505409.1	+	0	218																											atggatcctgagaatttgcat	0.418													2	4	---	---	---	---					
RP11-115J23.1	0	broad.mit.edu	37	11	28763434	28763434	+	RNA	DEL	A	A	-			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr11:28763434delA	ENST00000513853.1	+	0	283																											TTTATTGGTGAAAAAAAACTA	0.333													2	4	---	---	---	---					
RP11-460B17.3	0	broad.mit.edu	37	11	29465753	29465753	+	RNA	DEL	T	T	-	rs80244501		TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr11:29465753delT	ENST00000525097.1	-	0	153																											ctaaatcagcttttttttttt	0.388													2	4	---	---	---	---					
CTD-3138F19.1	0	broad.mit.edu	37	11	29801857	29801857	+	RNA	DEL	A	A	-	rs111319134		TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr11:29801857delA	ENST00000530249.1	+	0	232																											ctgtctctggaaaaaaaaaaa	0.463													2	4	---	---	---	---					
WT1-AS	51352	broad.mit.edu	37	11	32470689	32470690	+	RNA	INS	-	-	G	rs150390918		TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr11:32470689_32470690insG	ENST00000525436.1	+	0	46																				endometrium(1)|large_intestine(2)|lung(2)|prostate(1)	6						CAGATGGCTCTGGGGGGGTGAC	0.366													3	3	---	---	---	---					
RP11-148I19.1	0	broad.mit.edu	37	11	42117710	42117710	+	RNA	DEL	T	T	-			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr11:42117710delT	ENST00000534059.1	-	0	220																											gatctgatgatttgatcaggg	0.463													2	4	---	---	---	---					
RP11-703H8.9	0	broad.mit.edu	37	11	62023170	62023171	+	RNA	INS	-	-	A	rs2463819		TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr11:62023170_62023171insA	ENST00000529875.1	-	0	52																											actctgcctccaaaaaaaaaaa	0.465													2	4	---	---	---	---					
DISC1FP1	101929222	broad.mit.edu	37	11	90525126	90525127	+	RNA	INS	-	-	T			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr11:90525126_90525127insT	ENST00000562678.1	+	0	185																											TAGTTCATCACTTTTTTAATGC	0.322													2	4	---	---	---	---					
RP11-867G2.8	0	broad.mit.edu	37	11	94386996	94386997	+	RNA	INS	-	-	C	rs67140476	by1000genomes	TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr11:94386996_94386997insC	ENST00000536540.1	-	0	437				RP11-867G2.8_ENST00000537874.1_RNA																							ctggccccgagccccccagtac	0.520													2	4	---	---	---	---					
USP2-AS1	100499227	broad.mit.edu	37	11	119339824	119339825	+	RNA	INS	-	-	T			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr11:119339824_119339825insT	ENST00000498979.2	+	0	273				USP2-AS1_ENST00000530002.1_RNA|USP2-AS1_ENST00000500970.1_RNA|USP2-AS1_ENST00000578923.1_RNA	NR_034160.1																						ttgtctttttctttttttctga	0.495													2	4	---	---	---	---					
AP002856.5	0	broad.mit.edu	37	11	131190350	131190351	+	RNA	INS	-	-	T	rs72009859		TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr11:131190350_131190351insT	ENST00000606885.1	+	0	146																											AGTGAGTGttcttttttttttt	0.465													4	2	---	---	---	---					
RP11-114G22.1	0	broad.mit.edu	37	12	23184465	23184465	+	RNA	DEL	T	T	-	rs12581962		TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr12:23184465delT	ENST00000540895.1	+	0	508																											TTCTCGTGGGttttttttttt	0.413													2	4	---	---	---	---					
LOC101928441	101928441	broad.mit.edu	37	12	23259485	23259486	+	RNA	INS	-	-	A	rs146462556	by1000genomes	TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr12:23259485_23259486insA	ENST00000540895.1	+	0	1185																											aaacagaaaacaaaaaaaaaCC	0.391													2	4	---	---	---	---					
RP11-415I12.3	0	broad.mit.edu	37	12	64103656	64103656	+	RNA	DEL	A	A	-			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr12:64103656delA	ENST00000509615.2	-	0	238				RP11-415I12.2_ENST00000541353.1_RNA																							agcatgtgacaaagggagaat	0.289													2	4	---	---	---	---					
IFNG-AS1	100885789	broad.mit.edu	37	12	68495702	68495703	+	RNA	INS	-	-	C			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr12:68495702_68495703insC	ENST00000536914.1	+	0	336																											aacaacaccttccccccaacac	0.441													2	4	---	---	---	---					
RP11-114H23.1	0	broad.mit.edu	37	12	76082490	76082491	+	RNA	INS	-	-	T	rs141632958		TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr12:76082490_76082491insT	ENST00000552856.1	-	0	401																											cattctTTTTCTTTTTTTTTTT	0.361													4	5	---	---	---	---					
RP11-114H23.1	0	broad.mit.edu	37	12	76332281	76332282	+	RNA	DEL	AC	AC	-			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr12:76332281_76332282delAC	ENST00000552856.1	-	0	295																											GTGTacacatacacacacacac	0.396													2	4	---	---	---	---					
RP11-13A1.3	0	broad.mit.edu	37	12	89504691	89504691	+	RNA	DEL	A	A	-	rs72395915		TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr12:89504691delA	ENST00000549278.1	-	0	282																											aacctgtctcaaaaaaaaaaa	0.473													2	4	---	---	---	---					
RP11-13A1.3	0	broad.mit.edu	37	12	89507237	89507238	+	RNA	INS	-	-	A			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr12:89507237_89507238insA	ENST00000549278.1	-	0	282																											taaaaatgggcaaatgacctga	0.312													2	4	---	---	---	---					
PLXNC1	10154	broad.mit.edu	37	12	94543029	94543030	+	Frame_Shift_Ins	INS	-	-	C			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr12:94543029_94543030insC	ENST00000258526.4	+	1	531_532	c.282_283insC	c.(280-285)gcccccfs	p.AP94fs		NM_005761.2	NP_005752.1	O60486	PLXC1_HUMAN	plexin C1	94	Sema.				axon guidance|cell adhesion	integral to membrane|intracellular|plasma membrane	receptor activity|receptor binding			breast(2)|central_nervous_system(1)|cervix(2)|endometrium(4)|kidney(4)|large_intestine(12)|lung(30)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	64						TCTCGCTggcgccccccgcgcg	0.748													2	4	---	---	---	---					
DRAM1	55332	broad.mit.edu	37	12	102317557	102317558	+	RNA	INS	-	-	A			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr12:102317557_102317558insA	ENST00000551918.1	-	0	483_484																											CTGAGAAGGCCAAAAAAATCAC	0.411													2	4	---	---	---	---					
RP11-116D17.2	0	broad.mit.edu	37	12	115705597	115705597	+	RNA	DEL	C	C	-			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr12:115705597delC	ENST00000546696.1	+	0	152																											CAATTAGCAGCCCTCTGCTGC	0.577													2	4	---	---	---	---					
LINC00507	100862680	broad.mit.edu	37	12	128432484	128432484	+	RNA	DEL	A	A	-	rs149990793		TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr12:128432484delA	ENST00000540882.1	+	0	323				LINC00508_ENST00000538901.1_lincRNA																							TTCAAGAAGGAAAAAAAAAAA	0.378													2	4	---	---	---	---					
MEDAG	84935	broad.mit.edu	37	13	31480851	31480852	+	Frame_Shift_Ins	INS	-	-	G			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr13:31480851_31480852insG	ENST00000380482.4	+	1	524_525	c.199_200insG	c.(199-201)gggfs	p.G67fs	TEX26-AS1_ENST00000585870.1_RNA|TEX26-AS1_ENST00000592950.1_RNA|TEX26-AS1_ENST00000588726.1_RNA|TEX26-AS1_ENST00000590344.1_RNA|TEX26-AS1_ENST00000593246.1_RNA	NM_032849.3	NP_116238.2			mesenteric estrogen-dependent adipogenesis																		ggcggcggcgcgggggggcTTC	0.738													3	3	---	---	---	---					
SMIM2-AS1	101929212	broad.mit.edu	37	13	44759155	44759156	+	RNA	INS	-	-	T			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr13:44759155_44759156insT	ENST00000437867.1	+	0	219																											caaatactgcattttttcactc	0.396													2	4	---	---	---	---					
LINC00559	100874187	broad.mit.edu	37	13	90738653	90738654	+	RNA	INS	-	-	A			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr13:90738653_90738654insA	ENST00000569476.1	-	0	3282					NR_047489.1																						ttaaaatcagtaaaaaaagaaa	0.302													3	3	---	---	---	---					
LINC01049	101927224	broad.mit.edu	37	13	91175314	91175314	+	RNA	DEL	A	A	-			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr13:91175314delA	ENST00000426840.1	+	0	272																											gaagacaaggaaaaaaaaaca	0.353													2	4	---	---	---	---					
LOC101929735	101929735	broad.mit.edu	37	14	22874726	22874727	+	RNA	INS	-	-	A			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr14:22874726_22874727insA	ENST00000514473.2	-	0	225				AE000661.37_ENST00000541008.1_RNA|AE000661.37_ENST00000545670.1_RNA|AE000661.37_ENST00000535351.1_RNA																							AAAATTAAAGTAAAAAACCTGG	0.396													2	4	---	---	---	---					
LOC101927081	101927081	broad.mit.edu	37	14	27369850	27369850	+	RNA	DEL	G	G	-			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr14:27369850delG	ENST00000548170.1	+	0	435				RP11-384J4.2_ENST00000552303.1_lincRNA																							gataacagctggggtggggtg	0.388													2	4	---	---	---	---					
CTD-2251F13.1	0	broad.mit.edu	37	14	30675625	30675627	+	RNA	DEL	AAA	AAA	-	rs111314627		TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr14:30675625_30675627delAAA	ENST00000508469.2	-	0	69																											agattctgtcaaaaaaaaaaaaa	0.424													5	2	---	---	---	---					
LINC00639	283547	broad.mit.edu	37	14	39329922	39329923	+	RNA	INS	-	-	T	rs34965690		TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr14:39329922_39329923insT	ENST00000553932.1	-	0	154																											ctctttctctcttttttttttt	0.337													2	4	---	---	---	---					
CTD-2307P3.1	0	broad.mit.edu	37	14	43012461	43012461	+	RNA	DEL	T	T	-			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr14:43012461delT	ENST00000557251.1	+	0	166																											aatagtaggatttttttttct	0.338													2	4	---	---	---	---					
SYNJ2BP-COX16	100529257	broad.mit.edu	37	14	70835850	70835860	+	RNA	DEL	TTGAGACAAGG	TTGAGACAAGG	-	rs79998120		TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr14:70835850_70835860delTTGAGACAAGG	ENST00000555276.1	-	0	85																											ttttttgtttttgagacaaggtctcactccg	0.460													3	4	---	---	---	---					
RP11-187O7.3	0	broad.mit.edu	37	14	76984861	76984864	+	RNA	DEL	ATGA	ATGA	-	rs28418839		TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr14:76984861_76984864delATGA	ENST00000554926.1	-	0	310																											gaaaggagggatgaaggaaggaag	0.559													2	4	---	---	---	---					
HERC2P3	283755	broad.mit.edu	37	15	20607082	20607082	+	RNA	DEL	A	A	-	rs60421100		TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr15:20607082delA	ENST00000428453.1	-	0	4041																				central_nervous_system(1)|endometrium(11)|kidney(2)|large_intestine(1)|lung(14)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	35						GTCAGCATTTAAAAAAAAAAA	0.328													2	4	---	---	---	---					
LOC101928134	101928134	broad.mit.edu	37	15	33600971	33600972	+	RNA	DEL	CA	CA	-	rs5811751		TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr15:33600971_33600972delCA	ENST00000561458.1	-	0	97				RP11-489D6.2_ENST00000559457.1_RNA																							cacacccacccacacacacaca	0.446													3	3	---	---	---	---					
RP11-323I15.5	0	broad.mit.edu	37	15	35424465	35424465	+	RNA	DEL	A	A	-	rs35291338		TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr15:35424465delA	ENST00000559246.1	-	0	74																											tgtgggagctaaaaaaaaaaa	0.388													3	3	---	---	---	---					
RP11-108K3.1	0	broad.mit.edu	37	15	51401929	51401929	+	RNA	DEL	A	A	-			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr15:51401929delA	ENST00000559909.1	+	0	194																											TCACTGAATCAAAAGGAATTT	0.473													2	4	---	---	---	---					
RP11-382A20.4	0	broad.mit.edu	37	15	83924079	83924079	+	RNA	DEL	T	T	-	rs147181020		TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr15:83924079delT	ENST00000565495.1	+	0	264																											ttttaatcacttttttttttt	0.408													2	4	---	---	---	---					
RP11-648K4.2	0	broad.mit.edu	37	15	88141936	88141936	+	RNA	DEL	T	T	-	rs115449484	by1000genomes	TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr15:88141936delT	ENST00000560439.1	-	0	80																											gataagattctttttttttgg	0.308													2	4	---	---	---	---					
RP11-152L20.3	0	broad.mit.edu	37	15	92808642	92808642	+	RNA	DEL	A	A	-	rs11320265		TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr15:92808642delA	ENST00000561674.1	-	0	185																											gatctgagttaaaaaaaatac	0.249													2	4	---	---	---	---					
RP11-266O8.1	0	broad.mit.edu	37	15	93909456	93909457	+	RNA	DEL	GA	GA	-			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr15:93909456_93909457delGA	ENST00000543286.1	+	0	545																											gagtgaaagggagagagagaga	0.406													2	4	---	---	---	---					
CTD-2544M6.1	0	broad.mit.edu	37	15	98593381	98593383	+	RNA	DEL	TTC	TTC	-			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr15:98593381_98593383delTTC	ENST00000560360.1	-	0	291																											AGCTTCACTATTCTTCTTTTCCA	0.266													4	2	---	---	---	---					
RP11-10K17.6	0	broad.mit.edu	37	16	5174693	5174693	+	RNA	DEL	T	T	-	rs35165345		TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr16:5174693delT	ENST00000589323.1	+	0	247																											CCAATCCCTCTTTTTTTTTTT	0.428													2	4	---	---	---	---					
RP11-420N3.2	0	broad.mit.edu	37	16	5624582	5624582	+	RNA	DEL	T	T	-			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr16:5624582delT	ENST00000569895.1	+	0	343																											cgcccagcaattttttgtttg	0.517													4	2	---	---	---	---					
CTA-481E9.4	0	broad.mit.edu	37	16	18061962	18061962	+	RNA	DEL	A	A	-	rs72396467		TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr16:18061962delA	ENST00000567304.1	-	0	251																											GCAATCTTTTAAAAAAAAAAA	0.403													2	4	---	---	---	---					
RP11-42I10.1	0	broad.mit.edu	37	16	48672090	48672091	+	RNA	INS	-	-	T			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr16:48672090_48672091insT	ENST00000564212.1	+	0	157				CTC-527H23.3_ENST00000561876.1_lincRNA																							CTCtttttttcttttttttctt	0.401													3	3	---	---	---	---					
RP11-42I10.1	0	broad.mit.edu	37	16	48679737	48679740	+	RNA	DEL	TTGT	TTGT	-	rs140531874		TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr16:48679737_48679740delTTGT	ENST00000564212.1	+	0	157																											gtttttcttcttgtttgtttgttt	0.377													5	3	---	---	---	---					
CRNDE	643911	broad.mit.edu	37	16	54960661	54960662	+	RNA	DEL	AA	AA	-			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr16:54960661_54960662delAA	ENST00000560208.1	-	0	380																											AAATAAAAACAAGGCATTCCGT	0.292													2	4	---	---	---	---					
LOC101927580	101927580	broad.mit.edu	37	16	59925049	59925049	+	RNA	DEL	T	T	-			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr16:59925049delT	ENST00000568279.1	+	0	173																											tgctttatagttttagtgtac	0.229													2	4	---	---	---	---					
RP11-96H17.1	0	broad.mit.edu	37	16	63101541	63101542	+	RNA	INS	-	-	C			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr16:63101541_63101542insC	ENST00000563003.1	-	0	585																											CTGTCTCCATTCCCCCCGTCAA	0.342													2	4	---	---	---	---					
LOC101927650	101927650	broad.mit.edu	37	16	65185106	65185106	+	RNA	DEL	T	T	-			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr16:65185106delT	ENST00000563754.1	-	0	406																											tttttttgtatttttttcctt	0.348													2	4	---	---	---	---					
LINC01572	101927957	broad.mit.edu	37	16	72554333	72554333	+	RNA	DEL	T	T	-			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr16:72554333delT	ENST00000561611.2	-	0	113																											ataatgatccttttttttttc	0.378													3	5	---	---	---	---					
RP11-697E22.2	0	broad.mit.edu	37	17	36030090	36030091	+	RNA	INS	-	-	A	rs67804791	by1000genomes	TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr17:36030090_36030091insA	ENST00000586163.1	+	0	590				RP11-697E22.2_ENST00000586950.1_RNA																							tatttattatttttttttgaga	0.495													4	2	---	---	---	---					
MAP3K14	9020	broad.mit.edu	37	17	43368663	43368664	+	RNA	DEL	TG	TG	-	rs71970628		TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr17:43368663_43368664delTG	ENST00000344686.2	-	0	89							Q99558	M3K14_HUMAN	mitogen-activated protein kinase kinase kinase 14						cellular response to mechanical stimulus|I-kappaB kinase/NF-kappaB cascade|immune response|positive regulation of I-kappaB kinase/NF-kappaB cascade|T cell costimulation	cytosol	ATP binding|MAP kinase kinase kinase activity|NF-kappaB-inducing kinase activity|protein binding			breast(3)|central_nervous_system(4)|cervix(2)|endometrium(3)|kidney(1)|large_intestine(4)|lung(5)|ovary(2)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	27						GGTAGATATCtgtgtgtgtgtg	0.490													3	4	---	---	---	---					
LOC101927274	101927274	broad.mit.edu	37	17	49405087	49405087	+	RNA	DEL	A	A	-			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr17:49405087delA	ENST00000514726.1	-	0	1356																											gacgaatggcaaactagaata	0.393													2	4	---	---	---	---					
RP11-60A24.3	0	broad.mit.edu	37	17	55872958	55872958	+	RNA	DEL	A	A	-	rs113224879		TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr17:55872958delA	ENST00000580960.1	-	0	254																											caattgttttatgtgtgaaca	0.358													3	5	---	---	---	---					
LINC01483	101928122	broad.mit.edu	37	17	67623880	67623880	+	RNA	DEL	A	A	-			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr17:67623880delA	ENST00000433856.1	+	0	2473																											acaactcaggaaaaaaataaa	0.363													2	4	---	---	---	---					
CASC17	101928165	broad.mit.edu	37	17	69099195	69099195	+	RNA	DEL	A	A	-			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr17:69099195delA	ENST00000569074.1	-	0	215																											CAGTGGGAGTAAAAAAAGTGG	0.348													2	4	---	---	---	---					
RP11-78F17.1	0	broad.mit.edu	37	18	1057993	1057993	+	RNA	DEL	T	T	-			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr18:1057993delT	ENST00000580781.1	+	0	306																											aatttgcccatttttttccag	0.333													2	4	---	---	---	---					
RP11-92G19.2	0	broad.mit.edu	37	18	5083118	5083118	+	RNA	DEL	G	G	-			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr18:5083118delG	ENST00000583985.1	+	0	59																											actttgccctggggactggcc	0.458													2	4	---	---	---	---					
LINC00907	284260	broad.mit.edu	37	18	39998578	39998579	+	RNA	INS	-	-	G	rs72539923	by1000genomes	TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr18:39998578_39998579insG	ENST00000593234.1	+	0	713					NR_046456.1																						ATAAGCAACGTGCTTACAGAAG	0.317													2	4	---	---	---	---					
LOC400685	400685	broad.mit.edu	37	19	35315125	35315126	+	RNA	INS	-	-	C	rs149615237	by1000genomes	TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr19:35315125_35315126insC	ENST00000590963.1	-	0	563					NR_033982.1																						ccagaaatagaccatacaaata	0.351													2	4	---	---	---	---					
CTC-246B18.8	0	broad.mit.edu	37	19	39810073	39810074	+	RNA	INS	-	-	CA	rs112133589	by1000genomes	TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr19:39810073_39810074insCA	ENST00000601911.1	-	0	66																											GATACATACCTcacacacacac	0.450													7	3	---	---	---	---					
NSFL1C	55968	broad.mit.edu	37	20	1448429	1448429	+	RNA	DEL	C	C	-	rs60140956		TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr20:1448429delC	ENST00000553571.1	-	0	492																											cggtaaacaaccttcccgcgg	0.453													3	3	---	---	---	---					
CASC20	101929244	broad.mit.edu	37	20	6462363	6462363	+	RNA	DEL	G	G	-			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr20:6462363delG	ENST00000415932.1	+	0	218																											CCTGAGATGTGGCAGGGTCAT	0.433													2	4	---	---	---	---					
RP11-359G22.2	0	broad.mit.edu	37	20	22657953	22657954	+	RNA	DEL	AC	AC	-			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr20:22657953_22657954delAC	ENST00000441568.1	-	0	1075_1076																											tgggacgcagacacacacacac	0.490													2	4	---	---	---	---					
MIR646HG	284757	broad.mit.edu	37	20	58750927	58750927	+	RNA	DEL	T	T	-			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr20:58750927delT	ENST00000432910.1	+	0	253					NR_046099.1																						tcttgtttcatttttagcaga	0.353													2	4	---	---	---	---					
BAGE2	85319	broad.mit.edu	37	21	11032777	11032777	+	RNA	DEL	A	A	-			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr21:11032777delA	ENST00000470054.1	-	0	1476									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		CTTTGATGCCAAAATTTTATC	0.214													4	9	---	---	---	---					
AP001347.6	0	broad.mit.edu	37	21	15404542	15404542	+	RNA	DEL	T	T	-			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr21:15404542delT	ENST00000428809.1	+	0	177																											ctgacactgattcagagatca	0.438													2	4	---	---	---	---					
MIR99AHG	388815	broad.mit.edu	37	21	17729811	17729812	+	RNA	INS	-	-	G			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr21:17729811_17729812insG	ENST00000458468.1	+	0	469					NR_027790.1																						CTCAGCCGTGTGGGgtgtgtgt	0.441													2	4	---	---	---	---					
MIR99AHG	388815	broad.mit.edu	37	21	17886197	17886197	+	RNA	DEL	T	T	-	rs112009251		TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr21:17886197delT	ENST00000458468.1	+	0	518					NR_027790.1																						ACTTTTGTCCttttttttttt	0.388													2	4	---	---	---	---					
C21orf91-OT1	246312	broad.mit.edu	37	21	19141158	19141159	+	RNA	INS	-	-	C			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr21:19141158_19141159insC	ENST00000430815.1	-	0	230																											ATCATTGGTCACCCCCCAAATG	0.465													2	4	---	---	---	---					
LOC101927797	101927797	broad.mit.edu	37	21	20042543	20042543	+	RNA	DEL	A	A	-			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr21:20042543delA	ENST00000437492.1	-	0	332																											gcttatcttcaaaaaaataga	0.388													2	4	---	---	---	---					
AP000705.7	0	broad.mit.edu	37	21	23698136	23698137	+	RNA	DEL	AC	AC	-			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr21:23698136_23698137delAC	ENST00000444130.1	+	0	385																											ACATATGCAAACACACACACAC	0.292													2	4	---	---	---	---					
LOC339622	339622	broad.mit.edu	37	21	26214093	26214094	+	RNA	INS	-	-	A	rs115306787	by1000genomes	TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr21:26214093_26214094insA	ENST00000441009.1	+	0	179					NR_046198.3																						gctttattattaaaaaaaaagc	0.371													2	4	---	---	---	---					
AP000233.4	0	broad.mit.edu	37	21	26660594	26660596	+	RNA	DEL	GTT	GTT	-			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr21:26660594_26660596delGTT	ENST00000409758.1	-	0	89																											CGTTTCAGAAGTTGTTATCATGA	0.271													7	1	---	---	---	---					
AP000233.4	0	broad.mit.edu	37	21	26661151	26661151	+	RNA	DEL	T	T	-	rs78912674		TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr21:26661151delT	ENST00000409758.1	-	0	89																											GAGTTAGTCCTTTTTTTTTTT	0.438													2	4	---	---	---	---					
FTCD	10841	broad.mit.edu	37	21	47571576	47571576	+	Frame_Shift_Del	DEL	C	C	-			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr21:47571576delC	ENST00000397748.1	-	5	575	c.532delG	c.(532-534)cgfs	p.A178fs	FTCD_ENST00000355384.2_Frame_Shift_Del_p.A178fs|FTCD_ENST00000498355.2_5'UTR|FTCD_ENST00000291670.5_Frame_Shift_Del_p.A178fs|FTCD_ENST00000397743.1_Frame_Shift_Del_p.A178fs|FTCD_ENST00000397746.3_Frame_Shift_Del_p.A178fs|FTCD-AS1_ENST00000446649.1_RNA|FTCD_ENST00000359679.2_Frame_Shift_Del_p.A178fs			O95954	FTCD_HUMAN	formimidoyltransferase cyclodeaminase	178	Formiminotransferase N-subdomain (By similarity).				folic acid-containing compound metabolic process|histidine catabolic process	centriole|cytosol|Golgi apparatus	folic acid binding|formimidoyltetrahydrofolate cyclodeaminase activity|glutamate formimidoyltransferase activity			endometrium(1)|large_intestine(2)|lung(9)|pancreas(1)|prostate(3)|skin(3)	19	Breast(49;0.214)			Colorectal(79;0.235)	L-Glutamic Acid(DB00142)|Pyridoxal Phosphate(DB00114)|Tetrahydrofolic acid(DB00116)	AACTTCCTCGCCCCCGTGGCC	0.647													2	4	---	---	---	---					
CTA-292E10.6	0	broad.mit.edu	37	22	29234824	29234824	+	RNA	DEL	T	T	-			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr22:29234824delT	ENST00000458080.1	+	0	263				CTA-292E10.6_ENST00000418292.1_RNA																							GTTTCTTTCCTTTTTTTTTTC	0.408													2	4	---	---	---	---					
LL22NC03-86D4.1	0	broad.mit.edu	37	22	34534132	34534137	+	RNA	DEL	GTGTGT	GTGTGT	-	rs140034450		TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr22:34534132_34534137delGTGTGT	ENST00000412218.1	+	0	198																											ATACCCCATCgtgtgtgtgtgtgtgt	0.398													2	4	---	---	---	---					
LOC284930	284930	broad.mit.edu	37	22	48165453	48165453	+	RNA	DEL	T	T	-	rs80134842		TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chr22:48165453delT	ENST00000423737.1	+	0	1125																											atagtccccctatttgttgtc	0.383													3	3	---	---	---	---					
RP1-154K9.2	0	broad.mit.edu	37	X	42337106	42337107	+	RNA	INS	-	-	C			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chrX:42337106_42337107insC	ENST00000411879.1	+	0	452																											ctctttctctgccccttgctct	0.515													2	4	---	---	---	---					
RP1-154K9.2	0	broad.mit.edu	37	X	42505355	42505356	+	RNA	INS	-	-	A			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chrX:42505355_42505356insA	ENST00000411879.1	+	0	676																											TATGTACATTTAAAAAACACTA	0.302													2	4	---	---	---	---					
DGKK	139189	broad.mit.edu	37	X	50164260	50164260	+	RNA	DEL	A	A	-			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chrX:50164260delA	ENST00000376025.2	-	0	897							Q5KSL6	DGKK_HUMAN	diacylglycerol kinase, kappa						activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|diacylglycerol metabolic process|intracellular signal transduction|platelet activation|response to oxidative stress	cytoplasm|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			central_nervous_system(1)|endometrium(12)|kidney(4)|large_intestine(5)|lung(18)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	45	Ovarian(276;0.236)					CCCAGAGGGCAGGAGGGATCA	0.498													2	4	---	---	---	---					
FIRRE	286467	broad.mit.edu	37	X	130872439	130872439	+	RNA	DEL	C	C	-			TCGA-17-Z021-01A-01W-0746-08	TCGA-17-Z021-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9394b536-cd08-414b-86a3-c6491f967709	a1ff951a-725c-47d8-b214-82737a73f2dd	g.chrX:130872439delC	ENST00000427391.1	-	0	1930					NR_026975.1																						gagcgagactccatctcacac	0.458													2	4	---	---	---	---