Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
SPG7	6687	broad.mit.edu	37	16	89620342	89620342	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr16:89620342C>G	ENST00000268704.2	+	15	2092	c.2077C>G	c.(2077-2079)Caa>Gaa	p.Q693E		NM_003119.2	NP_003110.1	Q9UQ90	SPG7_HUMAN	spastic paraplegia 7 (pure and complicated autosomal recessive)	693					cell death|nervous system development|protein catabolic process|proteolysis	integral to membrane|mitochondrial membrane	ATP binding|metalloendopeptidase activity|nucleoside-triphosphatase activity|unfolded protein binding|zinc ion binding			autonomic_ganglia(1)|breast(2)|endometrium(2)|kidney(1)|large_intestine(4)|lung(7)|ovary(2)|urinary_tract(1)	20		all_hematologic(23;0.00824)|Colorectal(91;0.102)		all cancers(4;1.39e-07)|OV - Ovarian serous cystadenocarcinoma(4;5.64e-06)|BRCA - Breast invasive adenocarcinoma(80;0.015)		CCCCTTCAGCCAAGGCCTGCA	0.662000													7	18					0	0	0.248553	0	0
ZPLD1	131368	broad.mit.edu	37	3	102187940	102187940	+	Silent	SNP	C	C	A			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr3:102187940C>A	ENST00000306176.1	+	8	1042	c.942C>A	c.(940-942)acC>acA	p.T314T	ZPLD1_ENST00000491959.1_Silent_p.T298T|ZPLD1_ENST00000466937.1_Silent_p.T298T	NM_175056.1	NP_778226.1	Q8TCW7	ZPLD1_HUMAN	zona pellucida-like domain containing 1	298	ZP.					integral to membrane				central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(7)|lung(18)|ovary(2)|skin(3)	35						ACTGCGTTACCAAGCTCTGCA	0.433000													50	76					7.02699e-11	8.24247e-11	0.870114	1	0
MUC17	140453	broad.mit.edu	37	7	100681196	100681196	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr7:100681196C>G	ENST00000306151.4	+	3	6563	c.6499C>G	c.(6499-6501)Cct>Gct	p.P2167A		NM_001040105.1	NP_001035194.1	Q685J3	MUC17_HUMAN	mucin 17, cell surface associated	2167	59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			NS(3)|breast(14)|central_nervous_system(2)|cervix(2)|endometrium(27)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(28)|lung(179)|ovary(19)|pancreas(1)|prostate(13)|skin(26)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	343	Lung NSC(181;0.136)|all_lung(186;0.182)					AACAAGTATGCCTGTCAGCAC	0.468000													45	69					0	0	0.870114	0	0
MPPED2	744	broad.mit.edu	37	11	30516991	30516991	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr11:30516991G>C	ENST00000448418.2	-	4	748	c.388C>G	c.(388-390)Ctt>Gtt	p.L130V	MPPED2_ENST00000358117.5_Missense_Mutation_p.L130V	NM_001145399.1	NP_001138871.1	Q15777	MPPD2_HUMAN	metallophosphoesterase domain containing 2	130					nervous system development		hydrolase activity|metal ion binding			NS(1)|breast(2)|endometrium(4)|kidney(2)|large_intestine(4)|liver(1)|lung(15)|skin(2)|upper_aerodigestive_tract(2)	33						TGTTTAACAAGGTCTGCCATG	0.388000													19	69					0	0	0.608945	0	0
B4GALNT3	283358	broad.mit.edu	37	12	657408	657408	+	Silent	SNP	C	C	T			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr12:657408C>T	ENST00000266383.5	+	9	811	c.798C>T	c.(796-798)aaC>aaT	p.N266N	B4GALNT3_ENST00000544638.1_3'UTR	NM_173593.3	NP_775864.3	Q6L9W6	B4GN3_HUMAN	beta-1,4-N-acetyl-galactosaminyl transferase 3	266						Golgi cisterna membrane|integral to membrane	N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity			breast(1)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(1)|lung(10)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	26	all_cancers(10;0.0158)|all_epithelial(11;0.0274)|Ovarian(42;0.0512)|all_lung(10;0.154)|Lung NSC(10;0.215)		OV - Ovarian serous cystadenocarcinoma(31;0.00018)|BRCA - Breast invasive adenocarcinoma(9;0.0262)			GGCGACGGAACGACCCTGGAG	0.592000													8	14					0	0	0.361761	0	0
CACHD1	57685	broad.mit.edu	37	1	65099811	65099811	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr1:65099811G>A	ENST00000371073.2	+	7	874	c.874G>A	c.(874-876)Gag>Aag	p.E292K	CACHD1_ENST00000495994.1_3'UTR|CACHD1_ENST00000290039.5_Missense_Mutation_p.E241K			Q5VU97	CAHD1_HUMAN	cache domain containing 1	292	VWFA.				calcium ion transport	integral to membrane				breast(4)|endometrium(3)|kidney(3)|large_intestine(20)|lung(14)|ovary(2)|pancreas(1)|prostate(5)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	55						AGCCACCAGTGAGACAAAAAG	0.473000													17	41					0	0	0.539581	0	0
KDM5C	8242	broad.mit.edu	37	X	53231148	53231148	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chrX:53231148C>T	ENST00000452825.3	-	11	2085	c.1553G>A	c.(1552-1554)cGc>cAc	p.R518H	KDM5C_ENST00000375379.3_Missense_Mutation_p.R585H|KDM5C_ENST00000375383.3_Missense_Mutation_p.R544H|KDM5C_ENST00000465402.1_5'UTR|KDM5C_ENST00000375401.3_Missense_Mutation_p.R585H|KDM5C_ENST00000404049.3_Missense_Mutation_p.R584H	NM_001146702.1	NP_001140174.1	P41229	KDM5C_HUMAN	lysine (K)-specific demethylase 5C	585	JmjC.				chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|zinc ion binding			autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(30)|large_intestine(9)|lung(17)|oesophagus(1)|ovary(6)|prostate(1)|salivary_gland(1)|skin(1)|upper_aerodigestive_tract(2)	82						CTGGTTTGTGCGGACAACCTG	0.468000			"""N, F, S"""		clear cell renal carcinoma								3	37					0	0	0.115264	0	0
FOS	2353	broad.mit.edu	37	14	75747810	75747810	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr14:75747810G>A	ENST00000303562.4	+	4	1035	c.826G>A	c.(826-828)Gca>Aca	p.A276T	FOS_ENST00000555686.1_Missense_Mutation_p.A162T|FOS_ENST00000535987.1_Missense_Mutation_p.A240T|FOS_ENST00000555347.1_Missense_Mutation_p.A128T	NM_005252.3	NP_005243.1	P01100	FOS_HUMAN	FBJ murine osteosarcoma viral oncogene homolog	276					cellular response to reactive oxygen species|DNA methylation|inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|regulation of sequence-specific DNA binding transcription factor activity|SMAD protein signal transduction|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|transcription from RNA polymerase II promoter|transforming growth factor beta receptor signaling pathway		protein dimerization activity|R-SMAD binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			central_nervous_system(1)|large_intestine(1)|lung(5)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	12		all_lung(585;0.0138)|all_epithelial(191;0.0263)|all_neural(303;0.112)		BRCA - Breast invasive adenocarcinoma(234;0.0117)		CCTGTTCCCAGCATCATCCAG	0.582000													9	41					0	0	0.307466	0	0
SLC23A3	151295	broad.mit.edu	37	2	220034256	220034256	+	Missense_Mutation	SNP	A	A	C			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr2:220034256A>C	ENST00000455516.2	-	2	354	c.307T>G	c.(307-309)Tgg>Ggg	p.W103G	SLC23A3_ENST00000295738.7_Missense_Mutation_p.W103G|SLC23A3_ENST00000409878.3_Missense_Mutation_p.W103G|SLC23A3_ENST00000396775.3_Missense_Mutation_p.W45G	NM_001144890.1	NP_001138362.1	Q6PIS1	S23A3_HUMAN	solute carrier family 23, member 3	103					transmembrane transport	integral to membrane	protein binding|transporter activity			endometrium(3)|kidney(1)|large_intestine(2)|lung(4)|urinary_tract(1)	11		Renal(207;0.0474)		Epithelial(149;9.27e-07)|all cancers(144;0.000156)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		CTGCCCATCCAAGTTTGCAGG	0.577000													32	138					0	0	0.819951	0	0
TLN2	83660	broad.mit.edu	37	15	62949974	62949974	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr15:62949974G>C	ENST00000561311.1	+	8	895	c.665G>C	c.(664-666)cGg>cCg	p.R222P	TLN2_ENST00000306829.6_Missense_Mutation_p.R222P			Q9Y4G6	TLN2_HUMAN	talin 2	222	FERM.				cell adhesion|cell-cell junction assembly|cytoskeletal anchoring at plasma membrane	actin cytoskeleton|cytoplasm|focal adhesion|ruffle|synapse	actin binding|insulin receptor binding|structural constituent of cytoskeleton			NS(3)|breast(6)|central_nervous_system(3)|endometrium(8)|kidney(8)|large_intestine(20)|lung(34)|ovary(6)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(5)	99						TTTCAGGCACGGGATGACATC	0.512000													6	133					0	0	0.217242	0	0
GPR111	222611	broad.mit.edu	37	6	47645579	47645579	+	Splice_Site	SNP	G	G	A			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr6:47645579G>A	ENST00000398742.2	+	2	122	c.72_splice	c.e2-1	p.A25_splice	GPR111_ENST00000507065.1_Splice_Site_p.A25_splice|GPR111_ENST00000296862.1_Splice_Site_p.A93_splice			Q8IZF7	GP111_HUMAN	G protein-coupled receptor 111	93					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|liver(2)|lung(15)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	29						CCCTTTCTAGGCTGCAAGCAA	0.423000													13	77					0	0	0.479597	0	0
USP47	55031	broad.mit.edu	37	11	11944424	11944424	+	Translation_Start_Site	SNP	T	T	A			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr11:11944424T>A	ENST00000539466.1	+	0	1583				USP47_ENST00000399455.2_Missense_Mutation_p.S478T|USP47_ENST00000339865.5_Missense_Mutation_p.S390T|USP47_ENST00000527733.1_Missense_Mutation_p.S458T			Q96K76	UBP47_HUMAN	ubiquitin specific peptidase 47						base-excision repair|cellular response to UV|monoubiquitinated protein deubiquitination|negative regulation of apoptosis|negative regulation of caspase activity|negative regulation of G2/M transition of mitotic cell cycle|negative regulation of transcription, DNA-dependent|positive regulation of cell growth|response to drug|ubiquitin-dependent protein catabolic process	cytoplasm|SCF ubiquitin ligase complex	ubiquitin thiolesterase activity|ubiquitin-specific protease activity|WD40-repeat domain binding			breast(4)|endometrium(7)|kidney(2)|large_intestine(8)|liver(2)|lung(14)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	46				Epithelial(150;0.000339)		GATCTCAAAATCTGGACTTGA	0.343000													17	34					0	0	0.624587	0	0
OR2L2	26246	broad.mit.edu	37	1	248201629	248201629	+	Silent	SNP	A	A	T			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr1:248201629A>T	ENST00000366479.2	+	1	156	c.60A>T	c.(58-60)tcA>tcT	p.S20S	OR2L13_ENST00000366478.2_Intron	NM_001004686.2	NP_001004686.1	Q8NH16	OR2L2_HUMAN	olfactory receptor, family 2, subfamily L, member 2	20					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(28)|ovary(1)|skin(4)|urinary_tract(1)	42	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0278)			TCCCACAATCAAGAATTGGCC	0.383000													62	102					0	0	0.870114	0	0
WDR3	10885	broad.mit.edu	37	1	118479447	118479447	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr1:118479447A>T	ENST00000349139.4	+	4	484	c.437A>T	c.(436-438)aAg>aTg	p.K146M	WDR3_ENST00000369441.3_3'UTR|WDR3_ENST00000471680.1_3'UTR	NM_006784.2	NP_006775.1	Q9UNX4	WDR3_HUMAN	WD repeat domain 3	146						nuclear membrane|nucleolus				breast(2)|cervix(2)|endometrium(5)|kidney(4)|large_intestine(9)|liver(2)|lung(22)|prostate(2)|upper_aerodigestive_tract(1)	49	Esophageal squamous(2;0.162)	all_cancers(81;2.72e-05)|Acute lymphoblastic leukemia(138;1e-08)|all_epithelial(167;4.4e-07)|all_lung(203;1.7e-06)|Lung NSC(69;1.98e-05)|Prostate(1639;0.00955)|Breast(1374;0.244)		OV - Ovarian serous cystadenocarcinoma(397;1.39e-08)|Epithelial(280;1.82e-07)|all cancers(265;2.04e-05)|Lung(183;0.0525)|BRCA - Breast invasive adenocarcinoma(282;0.0695)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.185)		TACCGTCTAAAGGGGCACAAG	0.343000													48	99					0	0	0.870114	0	0
EPS8L2	64787	broad.mit.edu	37	11	722496	722496	+	Silent	SNP	C	C	A			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr11:722496C>A	ENST00000533256.1	+	14	1530	c.1155C>A	c.(1153-1155)gtC>gtA	p.V385V	AP006621.9_ENST00000527021.2_RNA|EPS8L2_ENST00000526198.1_Silent_p.V401V|EPS8L2_ENST00000530636.1_Silent_p.V385V|EPS8L2_ENST00000318562.8_Silent_p.V385V			Q9H6S3	ES8L2_HUMAN	EPS8-like 2	385						cytoplasm				NS(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(2)|pancreas(1)|prostate(2)|soft_tissue(1)|urinary_tract(1)	13		all_cancers(49;1.24e-08)|all_epithelial(84;1.87e-05)|Breast(177;0.000286)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.106)|all_lung(207;0.136)		all cancers(45;4.37e-27)|Epithelial(43;2.81e-26)|OV - Ovarian serous cystadenocarcinoma(40;1.33e-20)|BRCA - Breast invasive adenocarcinoma(625;4.29e-05)|Lung(200;0.0582)|LUSC - Lung squamous cell carcinoma(625;0.0703)		GCCACCTGGTCCCTAAGGAGA	0.672000													3	4					0.115264	0.117982	0.115264	1	0
NIN	51199	broad.mit.edu	37	14	51239175	51239175	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr14:51239175C>A	ENST00000245441.5	-	9	1015	c.825G>T	c.(823-825)gaG>gaT	p.E275D	NIN_ENST00000389868.3_Missense_Mutation_p.E275D|NIN_ENST00000382041.3_Missense_Mutation_p.E275D|NIN_ENST00000530997.2_Missense_Mutation_p.E275D|NIN_ENST00000324330.9_Missense_Mutation_p.E275D|NIN_ENST00000382043.4_Missense_Mutation_p.E275D|NIN_ENST00000453196.1_Missense_Mutation_p.E275D	NM_020921.3	NP_065972.3	Q8N4C6	NIN_HUMAN	ninein (GSK3B interacting protein)	275					centrosome localization	centrosome|microtubule	calcium ion binding|GTP binding|protein binding			breast(4)|central_nervous_system(1)|cervix(2)|endometrium(10)|kidney(5)|large_intestine(13)|lung(16)|ovary(1)|pancreas(1)|prostate(5)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(5)	71	all_epithelial(31;0.00244)|Breast(41;0.127)					GTCGTCCACTCTCATCGAAAG	0.502000			T	PDGFRB	MPD								30	55					1.45844e-13	1.76805e-13	0.769981	1	0
TRPM1	4308	broad.mit.edu	37	15	31318402	31318402	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr15:31318402C>A	ENST00000542188.1	-	26	3933	c.3620G>T	c.(3619-3621)cGg>cTg	p.R1207L	TRPM1_ENST00000256552.6_Missense_Mutation_p.R1190L|TRPM1_ENST00000397795.2_Missense_Mutation_p.R1168L|RP11-348B17.1_ENST00000561299.1_RNA	NM_001252020.1	NP_001238949.1	Q7Z4N2	TRPM1_HUMAN	transient receptor potential cation channel, subfamily M, member 1	1168					cellular response to light stimulus|visual perception	integral to plasma membrane	calcium channel activity|receptor activity			NS(2)|breast(3)|central_nervous_system(3)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(15)|lung(48)|ovary(2)|pancreas(1)|prostate(3)|skin(2)|soft_tissue(1)|upper_aerodigestive_tract(3)	99		all_lung(180;1.92e-11)		all cancers(64;3.52e-16)|Epithelial(43;1.65e-11)|GBM - Glioblastoma multiforme(186;3.57e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00533)|COAD - Colon adenocarcinoma(236;0.0609)|Lung(196;0.199)		CTCCTTCTCCCGGAAGTGCTC	0.617000													10	32					7.03913e-09	8.08196e-09	0.411799	1	0
STT3B	201595	broad.mit.edu	37	3	31656612	31656612	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr3:31656612A>G	ENST00000295770.2	+	6	1102	c.893A>G	c.(892-894)tAc>tGc	p.Y298C	STT3B_ENST00000453168.1_3'UTR	NM_178862.1	NP_849193.1	Q8TCJ2	STT3B_HUMAN	STT3B, subunit of the oligosaccharyltransferase complex (catalytic)	298					protein N-linked glycosylation via asparagine	integral to membrane|oligosaccharyltransferase complex	dolichyl-diphosphooligosaccharide-protein glycotransferase activity|protein binding			autonomic_ganglia(1)|biliary_tract(1)|breast(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|lung(3)|prostate(1)|upper_aerodigestive_tract(1)	19						AGCACTTTCTACATTGTGGGT	0.313000													19	23					0	0	0.539581	0	0
REV1	51455	broad.mit.edu	37	2	100021013	100021013	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr2:100021013C>T	ENST00000258428.3	-	18	3167	c.2939G>A	c.(2938-2940)gGa>gAa	p.G980E	REV1_ENST00000465835.1_5'UTR|REV1_ENST00000393445.3_Missense_Mutation_p.G979E	NM_001037872.1|NM_016316.2	NP_001032961.1|NP_057400.1	Q9UBZ9	REV1_HUMAN	REV1, polymerase (DNA directed)	980					DNA replication|error-prone translesion synthesis|response to UV	nucleoplasm	damaged DNA binding|DNA-directed DNA polymerase activity|magnesium ion binding|protein binding			NS(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(14)|lung(12)|ovary(2)|prostate(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	39						TGGCAAAATTCCTGTATTACA	0.448000								Direct reversal of damage					6	160					0	0	0.248553	0	0
NBEA	26960	broad.mit.edu	37	13	35630161	35630161	+	Silent	SNP	C	C	T			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr13:35630161C>T	ENST00000540320.1	+	7	1521	c.987C>T	c.(985-987)agC>agT	p.S329S	NBEA_ENST00000379939.2_Silent_p.S329S|NBEA_ENST00000400445.3_Silent_p.S329S|NBEA_ENST00000310336.4_Silent_p.S329S			Q8NFP9	NBEA_HUMAN	neurobeachin	329						cytosol|endomembrane system|plasma membrane|trans-Golgi network	protein binding			NS(1)|breast(1)|endometrium(14)|kidney(4)|large_intestine(29)|lung(40)|ovary(9)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	108		Breast(139;0.0141)|Lung SC(185;0.0548)|Prostate(109;0.207)		all cancers(112;1.93e-08)|Epithelial(112;1.62e-07)|BRCA - Breast invasive adenocarcinoma(63;0.00033)|OV - Ovarian serous cystadenocarcinoma(117;0.00109)|KIRC - Kidney renal clear cell carcinoma(186;0.00575)|Kidney(163;0.00656)|GBM - Glioblastoma multiforme(144;0.191)|Lung(94;0.199)		ACATGATCAGCATTGTCCACA	0.318000													4	48					0	0	0.335167	0	0
POLR2F	5435	broad.mit.edu	37	22	38355471	38355471	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr22:38355471C>T	ENST00000442738.2	+	3	334	c.209C>T	c.(208-210)gCg>gTg	p.A70V	POLR2F_ENST00000407936.1_Missense_Mutation_p.A70V|POLR2F_ENST00000488684.1_3'UTR|POLR2F_ENST00000484894.1_3'UTR|POLR2F_ENST00000470701.1_Missense_Mutation_p.A65V|POLR2F_ENST00000460648.1_Intron|POLR2F_ENST00000606538.1_Missense_Mutation_p.A70V|POLR2F_ENST00000405557.1_Missense_Mutation_p.A70V	NM_021974.3	NP_068809.1	P61218	RPAB2_HUMAN	polymerase (RNA) II (DNA directed) polypeptide F	70					mRNA capping|nuclear mRNA splicing, via spliceosome|positive regulation of viral transcription|protein phosphorylation|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase II promoter|transcription elongation from RNA polymerase III promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	DNA-directed RNA polymerase II, core complex|nucleolus	DNA binding|DNA-directed RNA polymerase activity			breast(1)|urinary_tract(2)	3	Melanoma(58;0.045)					GGCACCCGAGCGCTCCAGATT	0.592000													4	80					0	0	0.150653	0	0
PPP1R12A	4659	broad.mit.edu	37	12	80200036	80200036	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr12:80200036G>C	ENST00000450142.2	-	13	1999	c.1733C>G	c.(1732-1734)tCt>tGt	p.S578C	PPP1R12A_ENST00000261207.5_Missense_Mutation_p.S578C|AC073569.1_ENST00000598624.1_Intron|PPP1R12A_ENST00000550107.1_Intron|PPP1R12A_ENST00000437004.2_Missense_Mutation_p.S578C|PPP1R12A_ENST00000546369.1_Missense_Mutation_p.S491C	NM_002480.2	NP_002471.1	O14974	MYPT1_HUMAN	protein phosphatase 1, regulatory subunit 12A	578	Ser/Thr-rich.					contractile fiber	protein binding|signal transducer activity			breast(5)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(7)|liver(1)|lung(4)|ovary(2)|skin(1)	29						CCCAGCTGCAGAGGTAACTGT	0.433000													8	225					0	0	0.307466	0	0
KLRG1	10219	broad.mit.edu	37	12	9162084	9162084	+	Nonsense_Mutation	SNP	C	C	G			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr12:9162084C>G	ENST00000266551.4	+	5	536	c.521C>G	c.(520-522)tCa>tGa	p.S174*	KLRG1_ENST00000356986.3_Nonsense_Mutation_p.S174*|KLRG1_ENST00000538029.1_3'UTR	NM_005810.3	NP_005801.3	Q96E93	KLRG1_HUMAN	killer cell lectin-like receptor subfamily G, member 1	174	C-type lectin.				cell surface receptor linked signaling pathway|cellular defense response|inflammatory response|regulation of immune response	integral to membrane	receptor activity|sugar binding			breast(1)|central_nervous_system(1)|kidney(1)|lung(3)|pancreas(1)|upper_aerodigestive_tract(1)	8						CTTCAAGCCTCAAGCTGTGAA	0.433000													8	41					0	0	0.335167	0	0
GRIA4	2893	broad.mit.edu	37	11	105795326	105795326	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr11:105795326G>A	ENST00000393127.2	+	12	2124	c.1678G>A	c.(1678-1680)Gtg>Atg	p.V560M	GRIA4_ENST00000530497.1_Missense_Mutation_p.V560M|GRIA4_ENST00000282499.5_Missense_Mutation_p.V560M|GRIA4_ENST00000525187.1_Missense_Mutation_p.V560M	NM_001077243.2	NP_001070711.2	P48058	GRIA4_HUMAN	glutamate receptor, ionotropic, AMPA 4	560					glutamate signaling pathway|synaptic transmission	cell junction|endocytic vesicle membrane|integral to membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(24)|liver(2)|lung(25)|ovary(4)|pancreas(1)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(6)	82		Melanoma(852;0.000902)|Acute lymphoblastic leukemia(157;0.000994)|all_hematologic(158;0.0017)|Breast(348;0.0323)		BRCA - Breast invasive adenocarcinoma(274;0.000147)|Epithelial(105;0.0291)|all cancers(92;0.0899)	L-Glutamic Acid(DB00142)	TGGTGTCAGCGTGGTCTTATT	0.473000													13	36					0	0	0.411799	0	0
TLR9	54106	broad.mit.edu	37	3	52257315	52257315	+	Nonstop_Mutation	SNP	A	A	C			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr3:52257315A>C	ENST00000494383.1	-	5	1476	c.1477T>G	c.(1477-1479)Taa>Gaa	p.*493E	TLR9_ENST00000360658.2_Silent_p.L339L|TLR9_ENST00000597542.1_Silent_p.L363L			Q9NR96	TLR9_HUMAN	toll-like receptor 9	0					defense response to bacterium|fibroblast growth factor receptor signaling pathway|I-kappaB phosphorylation|inflammatory response|innate immune response|insulin receptor signaling pathway|maintenance of gastrointestinal epithelium|negative regulation of interleukin-6 production|negative regulation of interleukin-8 production|negative regulation of NF-kappaB transcription factor activity|negative regulation of toll-like receptor signaling pathway|positive regulation of chemokine production|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interferon-alpha biosynthetic process|positive regulation of interferon-beta biosynthetic process|positive regulation of interferon-beta production|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-10 production|positive regulation of interleukin-12 production|positive regulation of interleukin-18 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of JUN kinase activity|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of toll-like receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|response to molecule of bacterial origin	apical plasma membrane|basolateral plasma membrane|early phagosome|endoplasmic reticulum membrane|endosome membrane|extracellular region|integral to membrane|lysosome	interleukin-1 receptor binding|siRNA binding|transmembrane receptor activity			endometrium(4)|large_intestine(11)|lung(9)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	30				BRCA - Breast invasive adenocarcinoma(193;2.41e-05)|Kidney(197;0.000537)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)	Chloroquine(DB00608)	AGGACAGGTTAAGCTTGCGCA	0.557000													5	86					0	0	0.217242	0	0
UBQLNL	143630	broad.mit.edu	37	11	5537572	5537572	+	Missense_Mutation	SNP	T	T	G			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr11:5537572T>G	ENST00000380184.1	-	1	363	c.100A>C	c.(100-102)Ata>Cta	p.I34L	HBG2_ENST00000380259.2_Intron	NM_145053.4	NP_659490.4	Q8IYU4	UBQLN_HUMAN	ubiquilin-like	34	Ubiquitin-like.									endometrium(1)|kidney(3)|large_intestine(9)|lung(13)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	33		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;1.92e-09)|BRCA - Breast invasive adenocarcinoma(625;0.136)		GTCTTCACTATCACTCGAGTG	0.483000													13	46					0	0	0.435327	0	0
CCDC135	84229	broad.mit.edu	37	16	57731941	57731941	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr16:57731941G>T	ENST00000360716.3	+	3	301	c.80G>T	c.(79-81)aGg>aTg	p.R27M	CCDC135_ENST00000394337.4_Missense_Mutation_p.R27M|CCDC135_ENST00000336825.8_Missense_Mutation_p.R27M|RP11-405F3.4_ENST00000563062.1_RNA			Q8IY82	CC135_HUMAN	coiled-coil domain containing 135	27						cytoplasm				breast(1)|central_nervous_system(2)|cervix(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(12)|ovary(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	30						GAATGGGCGAGGATGGAGAAA	0.592000													6	15					0.00116845	0.00124903	0.217242	1	0
ATP11B	23200	broad.mit.edu	37	3	182635879	182635879	+	Nonsense_Mutation	SNP	C	C	G			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr3:182635879C>G	ENST00000323116.5	+	30	3781	c.3521C>G	c.(3520-3522)tCa>tGa	p.S1174*		NM_014616.2	NP_055431.1	Q9Y2G3	AT11B_HUMAN	ATPase, class VI, type 11B	1174					aminophospholipid transport|ATP biosynthetic process	integral to membrane|nuclear inner membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			breast(3)|cervix(2)|endometrium(2)|kidney(4)|large_intestine(6)|liver(2)|lung(14)|ovary(2)|pancreas(2)|prostate(1)|skin(2)|urinary_tract(1)	41	all_cancers(143;9.04e-15)|Ovarian(172;0.0355)		all cancers(12;1.2e-42)|Epithelial(37;2.77e-36)|LUSC - Lung squamous cell carcinoma(7;7.58e-24)|Lung(8;4.66e-22)|OV - Ovarian serous cystadenocarcinoma(80;2.35e-20)			ACAATGGACTCATCTACTTGT	0.438000													4	60					0	0	0.184627	0	0
CCNJ	54619	broad.mit.edu	37	10	97810018	97810018	+	Silent	SNP	G	G	A			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr10:97810018G>A	ENST00000265992.5	+	3	442	c.75G>A	c.(73-75)ctG>ctA	p.L25L	CCNJ_ENST00000465148.2_Silent_p.L25L|ENTPD1-AS1_ENST00000454638.1_RNA|ENTPD1-AS1_ENST00000458228.1_RNA|ENTPD1-AS1_ENST00000451364.1_RNA|ENTPD1-AS1_ENST00000416301.1_RNA|CCNJ_ENST00000403870.3_Silent_p.L25L|CCNJ_ENST00000534974.1_Silent_p.L25L|ENTPD1-AS1_ENST00000427846.1_RNA|ENTPD1-AS1_ENST00000452728.1_RNA	NM_001134375.1|NM_001134376.1|NM_019084.4	NP_001127847.1|NP_001127848.1|NP_061957.2	Q5T5M9	CCNJ_HUMAN	cyclin J	25	Cyclin N-terminal.					nucleus				breast(2)|endometrium(2)|kidney(2)|large_intestine(1)|lung(2)|ovary(1)|skin(1)	11				Epithelial(162;6.1e-08)|all cancers(201;2.32e-06)		CTTAGGAGCTGAAGTTGCCCT	0.423000													19	31					0	0	0.592651	0	0
NTM	50863	broad.mit.edu	37	11	132180026	132180026	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr11:132180026G>A	ENST00000374786.1	+	5	1161	c.682G>A	c.(682-684)Gcc>Acc	p.A228T	NTM_ENST00000374791.3_Missense_Mutation_p.A228T|NTM_ENST00000427481.2_Missense_Mutation_p.A219T|NTM_ENST00000539799.1_Missense_Mutation_p.A228T|NTM_ENST00000425719.2_Missense_Mutation_p.A228T|NTM_ENST00000474900.1_3'UTR|NTM_ENST00000374784.1_Missense_Mutation_p.A228T	NM_001144058.1|NM_016522.2	NP_001137530.1|NP_057606.1	Q9P121	NTRI_HUMAN	neurotrimin	228	Ig-like C2-type 3.				cell adhesion|neuron recognition	anchored to membrane|plasma membrane				breast(2)|central_nervous_system(1)|endometrium(4)|large_intestine(9)|lung(30)|ovary(4)|pancreas(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	56						CATTTCAGAAGCCAAGGGTAC	0.483000													4	151					0	0	0.150653	0	0
GFRAL	389400	broad.mit.edu	37	6	55223906	55223906	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr6:55223906C>A	ENST00000340465.2	+	6	1008	c.922C>A	c.(922-924)Cag>Aag	p.Q308K		NM_207410.2	NP_997293.2	Q6UXV0	GFRAL_HUMAN	GDNF family receptor alpha like	308						integral to membrane	receptor activity	p.Q308K(1)		NS(1)|breast(1)|endometrium(2)|kidney(5)|large_intestine(2)|liver(1)|lung(31)|ovary(1)|skin(2)|upper_aerodigestive_tract(2)	48	Lung NSC(77;0.0875)|Renal(3;0.122)		LUSC - Lung squamous cell carcinoma(124;0.23)			TAAGATTTTCCAGCACATGCT	0.358000													64	185					8.81991e-31	1.11925e-30	0.870114	1	0
RIN1	9610	broad.mit.edu	37	11	66099816	66099816	+	Silent	SNP	A	A	T			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr11:66099816A>T	ENST00000311320.4	-	10	2409	c.2283T>A	c.(2281-2283)ggT>ggA	p.G761G	RIN1_ENST00000424433.2_Intron|RIN1_ENST00000530056.1_Silent_p.G595G	NM_004292.2	NP_004283.2	Q13671	RIN1_HUMAN	Ras and Rab interactor 1	761					endocytosis|signal transduction	cytoplasm|cytoskeleton|plasma membrane	GTPase activator activity|protein binding			breast(1)|central_nervous_system(3)|haematopoietic_and_lymphoid_tissue(1)|lung(8)|ovary(1)	14						CCTGGGCTTGACCCTGGCCCC	0.642000													17	40					0	0	0.500413	0	0
PNLIP	5406	broad.mit.edu	37	10	118310710	118310710	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr10:118310710G>C	ENST00000369221.2	+	5	453	c.425G>C	c.(424-426)gGa>gCa	p.G142A	PNLIP_ENST00000470562.1_3'UTR	NM_000936.2	NP_000927.1	P16233	LIPP_HUMAN	pancreatic lipase	142					lipid catabolic process|retinoid metabolic process|steroid metabolic process	extracellular region	retinyl-palmitate esterase activity|triglyceride lipase activity			central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(6)|liver(2)|lung(22)|ovary(2)|skin(4)|upper_aerodigestive_tract(1)	43				all cancers(201;0.0131)	Bentiromide(DB00522)|Orlistat(DB01083)	AGGATCGTGGGAGCAGAAGTG	0.428000													9	22					0	0	0.411799	0	0
SDPR	8436	broad.mit.edu	37	2	192701434	192701434	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr2:192701434C>T	ENST00000304141.4	-	2	822	c.493G>A	c.(493-495)Gag>Aag	p.E165K		NM_004657.5	NP_004648.1	O95810	SDPR_HUMAN	serum deprivation response	165						caveola|cytosol	phosphatidylserine binding|protein binding			NS(1)|central_nervous_system(1)|cervix(1)|large_intestine(6)|lung(9)|ovary(1)|pancreas(1)|urinary_tract(3)	23			OV - Ovarian serous cystadenocarcinoma(117;0.0647)		Phosphatidylserine(DB00144)	GCAGGGATCTCATTTTCCTCC	0.468000													10	34					0	0	0.335167	0	0
SLC4A7	9497	broad.mit.edu	37	3	27436195	27436195	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr3:27436195C>A	ENST00000295736.5	-	20	2974	c.2904G>T	c.(2902-2904)atG>atT	p.M968I	SLC4A7_ENST00000428386.1_Missense_Mutation_p.M844I|SLC4A7_ENST00000388777.4_Missense_Mutation_p.M518I|SLC4A7_ENST00000437179.1_Missense_Mutation_p.M849I|SLC4A7_ENST00000455077.1_Missense_Mutation_p.M849I|SLC4A7_ENST00000435667.2_Missense_Mutation_p.M853I|SLC4A7_ENST00000454389.1_Missense_Mutation_p.M977I|SLC4A7_ENST00000446700.1_Missense_Mutation_p.M960I|SLC4A7_ENST00000425128.2_3'UTR|SLC4A7_ENST00000440156.1_Missense_Mutation_p.M964I|SLC4A7_ENST00000445684.1_Missense_Mutation_p.M964I	NM_003615.4	NP_003606.3	Q9Y6M7	S4A7_HUMAN	solute carrier family 4, sodium bicarbonate cotransporter, member 7	968						apical plasma membrane|basolateral plasma membrane|integral to membrane|stereocilium	inorganic anion exchanger activity|protein binding|sodium:bicarbonate symporter activity			NS(2)|breast(3)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(12)|lung(9)|ovary(4)|skin(1)	38						ATGGAAGTCCCATGACAGAGC	0.423000													4	169					0.014758	0.0153966	0.184627	1	0
PTPRB	5787	broad.mit.edu	37	12	70963486	70963486	+	Silent	SNP	C	C	T			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr12:70963486C>T	ENST00000334414.6	-	14	3647	c.3603G>A	c.(3601-3603)ctG>ctA	p.L1201L	PTPRB_ENST00000550358.1_Silent_p.L1113L|PTPRB_ENST00000551525.1_Silent_p.L1200L|PTPRB_ENST00000538708.1_Silent_p.L983L|PTPRB_ENST00000451516.2_Silent_p.L893L|PTPRB_ENST00000261266.5_Silent_p.L983L|PTPRB_ENST00000550857.1_Silent_p.L893L	NM_001109754.2	NP_001103224.1	P23467	PTPRB_HUMAN	protein tyrosine phosphatase, receptor type, B	983	Fibronectin type-III 14.				angiogenesis	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			breast(4)|central_nervous_system(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(8)|lung(46)|prostate(4)|skin(18)|upper_aerodigestive_tract(1)|urinary_tract(3)	107	Renal(347;0.236)		GBM - Glioblastoma multiforme(2;2.17e-05)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00306)|STAD - Stomach adenocarcinoma(21;0.149)			TCTGATTCTTCAGGGACCCGC	0.517000													14	77					0	0	0.457914	0	0
SLC12A1	6557	broad.mit.edu	37	15	48577413	48577413	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr15:48577413A>G	ENST00000396577.3	+	21	2811	c.2596A>G	c.(2596-2598)Aag>Gag	p.K866E	SLC12A1_ENST00000380993.3_Missense_Mutation_p.K866E|SLC12A1_ENST00000558405.1_Missense_Mutation_p.K866E	NM_001184832.1	NP_001171761.1	Q13621	S12A1_HUMAN	solute carrier family 12 (sodium/potassium/chloride transporter), member 1	866					potassium ion transport|sodium ion transport	integral to membrane|membrane fraction	sodium:potassium:chloride symporter activity			NS(2)|breast(3)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(14)|lung(30)|ovary(1)|prostate(2)|skin(1)	59		all_lung(180;0.00219)		all cancers(107;1.76e-09)|GBM - Glioblastoma multiforme(94;1.48e-06)	Bumetanide(DB00887)|Chlormerodrin(DB00534)|Chlorthalidone(DB00310)|Ethacrynic acid(DB00903)|Furosemide(DB00695)|Hydroflumethiazide(DB00774)|Methyclothiazide(DB00232)|Metolazone(DB00524)|Potassium Chloride(DB00761)|Torasemide(DB00214)|Trichlormethiazide(DB01021)	AAAAGCTGGCAAGTTGAACAT	0.368000													3	152					0	0	0.115264	0	0
OR6N2	81442	broad.mit.edu	37	1	158747247	158747247	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr1:158747247T>A	ENST00000339258.1	-	1	178	c.179A>T	c.(178-180)tAc>tTc	p.Y60F		NM_001005278.1	NP_001005278.1	Q8NGY6	OR6N2_HUMAN	olfactory receptor, family 6, subfamily N, member 2	60					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|large_intestine(6)|lung(10)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	24	all_hematologic(112;0.0378)					GACAAAGTGGTACATAGGTGT	0.433000													8	995					0	0	0.278610	0	0
C4orf40	401137	broad.mit.edu	37	4	71024571	71024571	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr4:71024571C>A	ENST00000344526.5	+	3	791	c.602C>A	c.(601-603)gCc>gAc	p.A201D	C4orf40_ENST00000502294.1_Missense_Mutation_p.A201D	NM_214711.3	NP_999876.2	Q6MZM9	CD040_HUMAN	chromosome 4 open reading frame 40	201	Ala-rich.					extracellular region				breast(2)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	12						CCTGCTACAGCCAAGCCTGCT	0.527000													9	44					0.00829132	0.00881969	0.361761	1	0
HEATR2	54919	broad.mit.edu	37	7	803599	803599	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr7:803599G>A	ENST00000297440.6	+	8	1791	c.1771G>A	c.(1771-1773)Gtc>Atc	p.V591I	HEATR2_ENST00000313147.5_Missense_Mutation_p.V591I	NM_017802.3	NP_060272.3	Q86Y56	HEAT2_HUMAN	HEAT repeat containing 2	591							protein binding			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(3)|ovary(2)|prostate(4)|skin(1)	22		Ovarian(82;0.0112)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0182)|Epithelial(4;5.48e-17)|OV - Ovarian serous cystadenocarcinoma(56;1.95e-16)|all cancers(6;2.98e-14)		CAGTGTCATCGTCGCACAGTC	0.667000													3	18					0	0	0.150653	0	0
DMWD	1762	broad.mit.edu	37	19	46287967	46287967	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr19:46287967C>T	ENST00000270223.6	-	4	1954	c.1909G>A	c.(1909-1911)Gac>Aac	p.D637N	DMWD_ENST00000377735.3_Intron|AC011530.4_ENST00000593999.1_Intron	NM_004943.1	NP_004934.1	Q09019	DMWD_HUMAN	dystrophia myotonica, WD repeat containing	637					meiosis					central_nervous_system(1)|endometrium(2)|large_intestine(5)|lung(6)|prostate(1)|upper_aerodigestive_tract(1)	16		Ovarian(192;0.0308)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.00604)|GBM - Glioblastoma multiforme(486;0.0807)|Epithelial(262;0.236)		gtctcctcgtctgtgaactac	0.557000													4	69					0	0	0.150653	0	0
ANO5	203859	broad.mit.edu	37	11	22281166	22281166	+	Silent	SNP	G	G	A			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr11:22281166G>A	ENST00000324559.8	+	15	1826	c.1509G>A	c.(1507-1509)caG>caA	p.Q503Q		NM_001142649.1|NM_213599.2	NP_001136121.1|NP_998764.1	Q75V66	ANO5_HUMAN	anoctamin 5	503						chloride channel complex|endoplasmic reticulum membrane	chloride channel activity			breast(2)|central_nervous_system(3)|endometrium(1)|kidney(2)|large_intestine(12)|lung(36)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	63						CCTTAAAGCAGGTCAAAAGCT	0.388000													4	58					0	0	0.217242	0	0
LINC00521	256369	broad.mit.edu	37	14	94467711	94467711	+	RNA	SNP	G	G	A			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr14:94467711G>A	ENST00000444118.1	+	0	789					NR_024182.1																						CGTGGCCCAGGGAGCTGGGGG	0.667000													3	15					0	0	0.150653	0	0
ANTXR2	118429	broad.mit.edu	37	4	80993620	80993620	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr4:80993620C>A	ENST00000403729.2	-	1	620	c.95G>T	c.(94-96)cGc>cTc	p.R32L	ANTXR2_ENST00000346652.6_Missense_Mutation_p.R32L|ANTXR2_ENST00000307333.7_Missense_Mutation_p.R32L|ANTXR2_ENST00000295465.4_Missense_Mutation_p.R32L|ANTXR2_ENST00000404191.1_Intron	NM_058172.5	NP_477520.2	P58335	ANTR2_HUMAN	anthrax toxin receptor 2	32						endoplasmic reticulum membrane|extracellular region|integral to membrane|plasma membrane	metal ion binding|protein binding|receptor activity			endometrium(2)|kidney(1)|large_intestine(2)|lung(7)|ovary(1)	13						CTCCTGGGCGCGCAGCAGCCC	0.701000									Juvenile Hyaline Fibromatosis				6	12					0.0381472	0.039232	0.278610	1	0
OR7E24	26648	broad.mit.edu	37	19	9361929	9361929	+	Silent	SNP	C	C	T			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr19:9361929C>T	ENST00000456448.1	+	1	324	c.210C>T	c.(208-210)gaC>gaT	p.D70D		NM_001079935.1	NP_001073404.1	Q6IFN5	O7E24_HUMAN	olfactory receptor, family 7, subfamily E, member 24	70					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|large_intestine(3)|lung(8)|ovary(1)|prostate(1)|skin(2)	16						TCAGCTCTGACTCCCACCTCC	0.582000													3	35					0	0	0.115264	0	0
STAT3	6774	broad.mit.edu	37	17	40474456	40474456	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr17:40474456A>G	ENST00000264657.5	-	21	2257	c.1945T>C	c.(1945-1947)Tca>Cca	p.S649P	STAT3_ENST00000404395.3_Missense_Mutation_p.S649P|STAT3_ENST00000588969.1_Missense_Mutation_p.S649P|STAT3_ENST00000585517.1_Missense_Mutation_p.S649P|STAT3_ENST00000389272.3_Missense_Mutation_p.S551P	NM_003150.3|NM_139276.2	NP_003141.2|NP_644805.1	P40763	STAT3_HUMAN	signal transducer and activator of transcription 3 (acute-phase response factor)	649	SH2.				cellular component movement|eating behavior|eye photoreceptor cell differentiation|glucose homeostasis|interleukin-6-mediated signaling pathway|interspecies interaction between organisms|JAK-STAT cascade involved in growth hormone signaling pathway|negative regulation of transcription from RNA polymerase II promoter|nerve growth factor receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|protein import into nucleus|response to estradiol stimulus|sexual reproduction|temperature homeostasis	cytosol|nucleus|plasma membrane	calcium ion binding|ligand-regulated transcription factor activity|protein dimerization activity|protein kinase binding|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription factor binding|transcription regulatory region DNA binding			breast(3)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(3)|lung(12)|ovary(1)|prostate(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	35		all_cancers(22;1.39e-06)|all_epithelial(22;2.95e-05)|Breast(137;0.000135)		BRCA - Breast invasive adenocarcinoma(366;0.139)		TCAGCAAATGACATGTTGTTC	0.473000									Hyperimmunoglobulin E Recurrent Infection Syndrome				6	101					0	0	0.307466	0	0
TTLL5	23093	broad.mit.edu	37	14	76135766	76135766	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr14:76135766C>T	ENST00000298832.9	+	3	287	c.82C>T	c.(82-84)Cca>Tca	p.P28S	TTLL5_ENST00000556977.1_Missense_Mutation_p.P28S|TTLL5_ENST00000557636.1_Missense_Mutation_p.P28S|TTLL5_ENST00000286650.5_Missense_Mutation_p.P28S	NM_015072.4	NP_055887.3	Q6EMB2	TTLL5_HUMAN	tubulin tyrosine ligase-like family, member 5	28					protein modification process|transcription, DNA-dependent	centrosome|cilium|microtubule basal body|nucleus	tubulin-tyrosine ligase activity			NS(2)|breast(2)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(1)|large_intestine(3)|lung(22)|ovary(2)|pancreas(1)|prostate(2)|skin(2)|urinary_tract(2)	50				BRCA - Breast invasive adenocarcinoma(234;0.029)		TAGGGATCATCCATGCATCAT	0.403000													54	122					0	0	0.870114	0	0
OR4P4	81300	broad.mit.edu	37	11	55405947	55405947	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr11:55405947G>T	ENST00000314612.2	+	1	114	c.114G>T	c.(112-114)atG>atT	p.M38I		NM_001004124.1	NP_001004124.1	Q8NGL7	OR4P4_HUMAN	olfactory receptor, family 4, subfamily P, member 4	38					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			autonomic_ganglia(1)|central_nervous_system(1)|kidney(4)|large_intestine(4)|lung(28)|ovary(1)|upper_aerodigestive_tract(1)	40						CTATTTGGATGGGAAACTTAC	0.373000													24	105					9.22233e-05	0.000100565	0.681144	1	0
RMDN1	51115	broad.mit.edu	37	8	87487113	87487113	+	Missense_Mutation	SNP	T	T	G			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr8:87487113T>G	ENST00000406452.3	-	9	989	c.830A>C	c.(829-831)aAg>aCg	p.K277T	RMDN1_ENST00000430676.2_Missense_Mutation_p.K247T|RMDN1_ENST00000523911.1_Missense_Mutation_p.K220T|RMDN1_ENST00000519966.1_Missense_Mutation_p.K234T	NM_016033.2	NP_057117.2			regulator of microtubule dynamics 1																		AGCAGCAAGCTTTTTGTTGTG	0.378000													4	70					0	0	0.217242	0	0
OR9G4	283189	broad.mit.edu	37	11	56510345	56510345	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr11:56510345C>A	ENST00000302957.3	-	1	942	c.943G>T	c.(943-945)Gcc>Tcc	p.A315S		NM_001005284.1	NP_001005284.1	Q8NGQ1	OR9G4_HUMAN	olfactory receptor, family 9, subfamily G, member 4	315					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|autonomic_ganglia(1)|endometrium(2)|kidney(2)|large_intestine(3)|liver(1)|lung(15)|ovary(2)|prostate(2)|skin(3)|stomach(1)|urinary_tract(1)	34						TTCCTGAAGGCCTCTTTGATA	0.408000													23	49					3.08376e-08	3.52198e-08	0.654019	1	0
POT1	25913	broad.mit.edu	37	7	124503684	124503684	+	Translation_Start_Site	SNP	T	T	C			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr7:124503684T>C	ENST00000393329.1	-	0	735				POT1_ENST00000357628.3_Missense_Mutation_p.Y89C	NM_001042594.1	NP_001036059.1	Q9NUX5	POTE1_HUMAN	protection of telomeres 1						DNA duplex unwinding|negative regulation of telomere maintenance via telomerase|positive regulation of DNA strand elongation|positive regulation of helicase activity|positive regulation of telomerase activity|positive regulation of telomere maintenance via telomerase|telomere capping|telomere formation via telomerase|telomere maintenance via telomerase	nuclear telomere cap complex|nucleoplasm	DEAD/H-box RNA helicase binding|single-stranded telomeric DNA binding|telomerase inhibitor activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(4)|liver(1)|lung(23)|ovary(1)|prostate(1)|skin(3)|stomach(1)|urinary_tract(1)	47						CTCCTTTTTATATACTTGAAT	0.398000													32	94					0	0	0.769981	0	0
MT-TY	0	broad.mit.edu	37	MT	5887	5887	+	RNA	SNP	T	T	C			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chrM:5887T>C	ENST00000387409.1	-	0	4																											ACTCAGCCATTTTACCTCACC	0.438000													11	305					0	0	0.457914	0	0
HMCN1	83872	broad.mit.edu	37	1	186050516	186050516	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr1:186050516G>A	ENST00000271588.4	+	56	9006	c.8777G>A	c.(8776-8778)cGa>cAa	p.R2926Q	HMCN1_ENST00000367492.2_Missense_Mutation_p.R2926Q	NM_031935.2	NP_114141.2	Q96RW7	HMCN1_HUMAN	hemicentin 1	2926	Ig-like C2-type 27.				response to stimulus|visual perception	basement membrane	calcium ion binding	p.R2926Q(1)		NS(2)|autonomic_ganglia(1)|breast(10)|central_nervous_system(2)|cervix(1)|endometrium(28)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(58)|liver(3)|lung(101)|ovary(23)|pancreas(4)|prostate(20)|skin(8)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(18)	308						TCTAATGGACGAATTCTGCAG	0.338000													47	170					0	0	0.870114	0	0
ADAMTS20	80070	broad.mit.edu	37	12	43860531	43860531	+	Missense_Mutation	SNP	C	C	A	rs149591802	byFrequency	TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr12:43860531C>A	ENST00000389420.3	-	9	1290	c.1291G>T	c.(1291-1293)Gcc>Tcc	p.A431S	ADAMTS20_ENST00000553158.1_Missense_Mutation_p.A431S	NM_025003.3	NP_079279.3	P59510	ATS20_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 20	431	Peptidase M12B.					proteinaceous extracellular matrix	zinc ion binding			breast(1)|central_nervous_system(6)|endometrium(3)|kidney(4)|large_intestine(11)|liver(1)|lung(43)|ovary(4)|pancreas(3)|prostate(5)|skin(12)|upper_aerodigestive_tract(1)|urinary_tract(1)	95	all_cancers(12;2.6e-05)|Lung SC(27;0.184)	Lung NSC(34;0.0569)|all_lung(34;0.129)		GBM - Glioblastoma multiforme(48;0.0473)		AAAGCAGGGGCCATTACATGA	0.303000													18	44					8.10497e-08	9.16031e-08	0.592651	1	0
NLRP5	126206	broad.mit.edu	37	19	56552450	56552450	+	Silent	SNP	G	G	A			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr19:56552450G>A	ENST00000390649.3	+	11	2949	c.2949G>A	c.(2947-2949)caG>caA	p.Q983Q		NM_153447.4	NP_703148.4	P59047	NALP5_HUMAN	NLR family, pyrin domain containing 5	983						mitochondrion|nucleolus	ATP binding			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|ovary(5)|skin(2)|stomach(4)|upper_aerodigestive_tract(2)	25		Colorectal(82;3.46e-05)|Ovarian(87;0.0481)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0326)		GTAGTCTGCAGAGGCTGATGT	0.537000													10	205					0	0	0.387290	0	0
NACAP1	83955	broad.mit.edu	37	8	102381116	102381116	+	RNA	SNP	G	G	C			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr8:102381116G>C	ENST00000419462.1	+	0	528					NR_002182.1																						CCGCCATCTTGATTCCACGTT	0.537000													9	7					0	0	0.335167	0	0
GOLGA6L5P	374650	broad.mit.edu	37	15	85059998	85059998	+	RNA	SNP	G	G	A			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr15:85059998G>A	ENST00000560239.1	-	0	169																											TGGGGAGGGAGGCGGGGTTGG	0.582000													4	6					0	0	0.150653	0	0
LINC01410	103352539	broad.mit.edu	37	9	66459909	66459909	+	RNA	SNP	T	T	C	rs146531631	by1000genomes	TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr9:66459909T>C	ENST00000424345.1	+	0	169																											cattaaaatcttgggcatgca	0.368000													5	31					0	0	0.248553	0	0
SLC35B2	347734	broad.mit.edu	37	6	44224130	44224130	+	Silent	SNP	G	G	A			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr6:44224130G>A	ENST00000393812.3	-	3	452	c.309C>T	c.(307-309)acC>acT	p.T103T	SLC35B2_ENST00000495706.1_5'UTR|SLC35B2_ENST00000393810.1_Intron|SLC35B2_ENST00000538577.1_Intron|SLC35B2_ENST00000537814.1_Intron	NM_178148.2	NP_835361.1	Q8TB61	S35B2_HUMAN	solute carrier family 35 (adenosine 3'-phospho 5'-phosphosulfate transporter), member B2	103					positive regulation of I-kappaB kinase/NF-kappaB cascade	Golgi membrane|integral to membrane	3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity|signal transducer activity			breast(1)|central_nervous_system(2)|kidney(3)|large_intestine(2)|lung(4)|ovary(2)|urinary_tract(1)	15	all_cancers(18;2e-05)|all_lung(25;0.00747)|Hepatocellular(11;0.00908)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)			ACATCGGGGTGGTCTCTGCCG	0.637000													9	92					0	0	0.520397	0	0
PAPOLB	56903	broad.mit.edu	37	7	4901105	4901105	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr7:4901105C>T	ENST00000404991.1	-	1	520	c.334G>A	c.(334-336)Gca>Aca	p.A112T	RADIL_ENST00000536091.1_Intron|RADIL_ENST00000399583.3_Intron	NM_020144.4	NP_064529.4	Q9NRJ5	PAPOB_HUMAN	poly(A) polymerase beta (testis specific)	112					mRNA processing|RNA polyadenylation|transcription, DNA-dependent	nucleus	ATP binding|metal ion binding|polynucleotide adenylyltransferase activity|RNA binding			kidney(1)|large_intestine(6)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|stomach(1)	14		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.089)|OV - Ovarian serous cystadenocarcinoma(56;2.06e-14)		TCAATATCTGCGCCTTTCGTA	0.423000													4	46					0	0	0.150653	0	0
LINS	55180	broad.mit.edu	37	15	101110081	101110081	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr15:101110081C>T	ENST00000314742.8	-	7	1858	c.1636G>A	c.(1636-1638)Gat>Aat	p.D546N		NM_001040616.2	NP_001035706.1	Q8NG48	LINES_HUMAN	lines homolog (Drosophila)	546										central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(3)|ovary(1)|prostate(1)|skin(1)|stomach(4)	21						TCAGTTGCATCAAAGTTATTG	0.348000													23	26					0	0	0.681144	0	0
MUC16	94025	broad.mit.edu	37	19	9072492	9072492	+	Nonsense_Mutation	SNP	G	G	T			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr19:9072492G>T	ENST00000397910.4	-	3	15157	c.14954C>A	c.(14953-14955)tCa>tAa	p.S4985*		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	4987	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						AGTATCCTGTGATGTAGCCCC	0.473000													37	55					2.75727e-19	3.39959e-19	0.804634	1	0
PCDH17	27253	broad.mit.edu	37	13	58299398	58299398	+	Silent	SNP	G	G	C	rs141868878		TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr13:58299398G>C	ENST00000377918.3	+	4	3476	c.3450G>C	c.(3448-3450)cgG>cgC	p.R1150R		NM_001040429.2	NP_001035519.1	O14917	PCD17_HUMAN	protocadherin 17	1150					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(30)|liver(2)|lung(54)|ovary(4)|pancreas(2)|prostate(5)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	120		Lung NSC(96;0.027)|Prostate(109;0.0453)|Breast(118;0.128)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;1.06e-05)		AAGACTGCCGGGGAAACGACC	0.443000													58	110					0	0	0.870114	0	0
NLN	57486	broad.mit.edu	37	5	65077205	65077205	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr5:65077205C>G	ENST00000380985.5	+	6	957	c.779C>G	c.(778-780)aCc>aGc	p.T260S	NLN_ENST00000502464.1_Missense_Mutation_p.T156S	NM_020726.4	NP_065777.1	Q9BYT8	NEUL_HUMAN	neurolysin (metallopeptidase M3 family)	260					proteolysis	mitochondrial intermembrane space	metal ion binding|metalloendopeptidase activity			central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(4)|lung(10)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	26		Lung NSC(167;7.21e-05)|Prostate(74;0.0174)|Ovarian(174;0.186)		UCEC - Uterine corpus endometrioid carcinoma (4;0.0743)|Lung(70;0.00616)		ATCCCTGAAACCAGAAGAAGG	0.303000													26	21					0	0	0.693898	0	0
RIN3	79890	broad.mit.edu	37	14	93118141	93118141	+	Silent	SNP	C	C	T			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr14:93118141C>T	ENST00000216487.7	+	6	906	c.747C>T	c.(745-747)acC>acT	p.T249T	RIN3_ENST00000418924.2_3'UTR	NM_024832.3	NP_079108.3	Q8TB24	RIN3_HUMAN	Ras and Rab interactor 3	249	Pro-rich.				endocytosis|signal transduction	cytoplasmic membrane-bounded vesicle|early endosome	GTPase activator activity|Ras GTPase binding			endometrium(4)|kidney(2)|large_intestine(7)|lung(19)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	36		all_cancers(154;0.0701)				CCCTGCCCACCGACCAGCCAC	0.617000													7	59					0	0	0.387290	0	0
PDE10A	10846	broad.mit.edu	37	6	165792718	165792718	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr6:165792718C>A	ENST00000366882.1	-	19	2074	c.1920G>T	c.(1918-1920)caG>caT	p.Q640H	PDE10A_ENST00000354448.4_Missense_Mutation_p.Q640H|PDE10A_ENST00000539869.2_Missense_Mutation_p.Q650H			Q9Y233	PDE10_HUMAN	phosphodiesterase 10A	640					platelet activation|signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cAMP binding|cGMP binding|metal ion binding			breast(4)|endometrium(5)|kidney(1)|large_intestine(13)|liver(1)|lung(39)|ovary(3)|skin(4)|upper_aerodigestive_tract(1)	71		Breast(66;0.000425)|Prostate(117;0.104)|Ovarian(120;0.221)		OV - Ovarian serous cystadenocarcinoma(33;1.5e-17)|BRCA - Breast invasive adenocarcinoma(81;1.8e-06)|GBM - Glioblastoma multiforme(31;1.92e-05)	Dipyridamole(DB00975)	GTGATCCGGTCTGGTACATCT	0.373000													12	61					0.000151284	0.000164144	0.435327	1	0
CDH5	1003	broad.mit.edu	37	16	66413319	66413319	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr16:66413319G>C	ENST00000341529.3	+	2	227	c.79G>C	c.(79-81)Ggt>Cgt	p.G27R	CDH5_ENST00000563425.2_Missense_Mutation_p.G27R	NM_001795.3	NP_001786.2	P33151	CADH5_HUMAN	cadherin 5, type 2 (vascular endothelium)	27					adherens junction organization|cell junction assembly|homophilic cell adhesion|regulation of establishment of cell polarity	integral to membrane|membrane fraction	beta-catenin binding|calcium ion binding|ion channel binding|receptor binding			central_nervous_system(1)|endometrium(3)|kidney(18)|large_intestine(2)|lung(17)|ovary(2)|prostate(5)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	54		Ovarian(137;0.0955)		OV - Ovarian serous cystadenocarcinoma(108;0.107)		GGCAGCAGCAGGTGCTAACCC	0.602000													6	30					0	0	0.248553	0	0
RFX6	222546	broad.mit.edu	37	6	117216355	117216355	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr6:117216355C>A	ENST00000332958.2	+	6	673	c.657C>A	c.(655-657)agC>agA	p.S219R	RFX6_ENST00000471966.1_3'UTR	NM_173560.3	NP_775831.2	Q8HWS3	RFX6_HUMAN	regulatory factor X, 6	219					glucose homeostasis|pancreatic A cell differentiation|pancreatic D cell differentiation|pancreatic E cell differentiation|positive regulation of transcription, DNA-dependent|regulation of insulin secretion|transcription, DNA-dependent|type B pancreatic cell differentiation	nucleus	protein binding|transcription regulatory region DNA binding			cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(29)|ovary(1)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	59						TTTCTGGAAGCAAGCTAAAGA	0.299000													10	11					9.70103e-10	1.11975e-09	0.361761	1	0
PAPOLA	10914	broad.mit.edu	37	14	97022723	97022723	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr14:97022723G>C	ENST00000216277.8	+	19	2197	c.1977G>C	c.(1975-1977)gaG>gaC	p.E659D	PAPOLA_ENST00000392990.2_Missense_Mutation_p.E659D	NM_032632.4	NP_116021.2	P51003	PAPOA_HUMAN	poly(A) polymerase alpha	659					mRNA polyadenylation|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	cytoplasm|nucleoplasm	ATP binding|magnesium ion binding|manganese ion binding|polynucleotide adenylyltransferase activity|RNA binding			breast(1)|endometrium(5)|kidney(3)|large_intestine(4)|lung(6)|skin(1)|urinary_tract(1)	21		all_cancers(154;0.0555)|all_epithelial(191;0.149)|Melanoma(154;0.155)		COAD - Colon adenocarcinoma(157;0.213)		ATAAAGAAGAGAGTCCCAAGA	0.378000													179	286					0	0	0.870114	0	0
HECW1	23072	broad.mit.edu	37	7	43503272	43503272	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr7:43503272C>A	ENST00000395891.1	+	14	3270	c.2665C>A	c.(2665-2667)Cag>Aag	p.Q889K	HECW1_ENST00000453890.1_Missense_Mutation_p.Q855K	NM_015052.3	NP_055867.3	Q76N89	HECW1_HUMAN	HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1	889					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	ubiquitin-protein ligase activity			NS(2)|breast(10)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(17)|lung(57)|ovary(8)|pancreas(2)|prostate(2)|skin(6)|urinary_tract(3)	125						TCAAAACATTCAGCGAACCAT	0.483000													13	30					2.61681e-11	3.08613e-11	0.457914	1	0
PCDHA4	56144	broad.mit.edu	37	5	140188367	140188367	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr5:140188367A>T	ENST00000530339.1	+	1	1595	c.1595A>T	c.(1594-1596)cAg>cTg	p.Q532L	PCDHA1_ENST00000504120.2_Intron|PCDHA4_ENST00000356878.4_Missense_Mutation_p.Q532L|PCDHA1_ENST00000394633.3_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA4_ENST00000512229.2_Missense_Mutation_p.Q532L	NM_018907.2	NP_061730.1														breast(6)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(12)|lung(33)|ovary(6)|pancreas(1)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	78			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GAGCTGCTGCAGTTTCAGGTG	0.652000													26	17					0	0	0.779181	0	0
BIN1	274	broad.mit.edu	37	2	127818195	127818195	+	Silent	SNP	C	C	T			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr2:127818195C>T	ENST00000259238.4	-	10	1130	c.786G>A	c.(784-786)tcG>tcA	p.S262S	BIN1_ENST00000393041.3_Intron|BIN1_ENST00000357970.3_Intron|BIN1_ENST00000316724.5_Intron|BIN1_ENST00000393040.3_Intron|BIN1_ENST00000346226.3_Intron|BIN1_ENST00000376113.2_Silent_p.S262S|BIN1_ENST00000466111.1_Intron|BIN1_ENST00000348750.4_Intron|BIN1_ENST00000352848.3_Silent_p.S262S|BIN1_ENST00000351659.3_Intron|BIN1_ENST00000409400.1_Intron	NM_139346.2	NP_647596.1	O00499	BIN1_HUMAN	bridging integrator 1	285	BAR.				cell proliferation|endocytosis|interspecies interaction between organisms|multicellular organismal development	actin cytoskeleton|nucleus				NS(1)|breast(1)|central_nervous_system(2)|endometrium(2)|large_intestine(3)|lung(6)|ovary(3)|prostate(3)|skin(3)	24	Colorectal(110;0.0831)			BRCA - Breast invasive adenocarcinoma(221;0.073)		TGCGCAGCCGCGAAAACAGTT	0.627000													3	24					0	0	0.184627	0	0
TRDN	10345	broad.mit.edu	37	6	123709670	123709670	+	Nonsense_Mutation	SNP	C	C	A			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr6:123709670C>A	ENST00000334268.4	-	14	1449	c.1132G>T	c.(1132-1134)Gaa>Taa	p.E378*	TRDN_ENST00000398178.3_Nonsense_Mutation_p.E378*			Q13061	TRDN_HUMAN	triadin	378					muscle contraction	integral to membrane|plasma membrane|sarcoplasmic reticulum membrane	receptor binding			NS(1)|endometrium(1)|kidney(1)|large_intestine(8)|liver(1)|lung(22)|ovary(2)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)	41				GBM - Glioblastoma multiforme(226;0.184)		AACATACCTTCCTTCTTTTCA	0.383000													7	13					2.17888e-05	2.40008e-05	0.335167	1	0
LMAN2	10960	broad.mit.edu	37	5	176778186	176778186	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr5:176778186G>C	ENST00000303127.7	-	2	507	c.303C>G	c.(301-303)atC>atG	p.I101M	LMAN2_ENST00000506310.1_5'UTR|LMAN2_ENST00000515209.1_Missense_Mutation_p.I101M	NM_006816.2	NP_006807.1	Q12907	LMAN2_HUMAN	lectin, mannose-binding 2	101	L-type lectin-like.				protein transport	endoplasmic reticulum membrane|ER-Golgi intermediate compartment membrane|Golgi membrane|integral to membrane	metal ion binding|sugar binding			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(6)|upper_aerodigestive_tract(1)	16	all_cancers(89;2.04e-05)|Renal(175;0.000269)|Lung NSC(126;0.000832)|all_lung(126;0.00152)	all_neural(177;0.00802)|Medulloblastoma(196;0.0145)|all_hematologic(541;0.248)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			GGTGGTTCCAGATAGAGCCCT	0.582000													28	101					0	0	0.717897	0	0
ADAMTS12	81792	broad.mit.edu	37	5	33684007	33684007	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr5:33684007C>A	ENST00000504830.1	-	4	1123	c.788G>T	c.(787-789)gGg>gTg	p.G263V	ADAMTS12_ENST00000504582.1_5'UTR|ADAMTS12_ENST00000352040.3_Missense_Mutation_p.G263V	NM_030955.2	NP_112217.2	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 12	263	Peptidase M12B.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(7)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(11)|large_intestine(31)|liver(1)|lung(135)|ovary(4)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(5)	216						ATTCTCACTCCCATGGTATTC	0.512000										HNSCC(64;0.19)			53	85					5.19286e-32	6.70744e-32	0.870114	1	0
NSD1	64324	broad.mit.edu	37	5	176709559	176709559	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr5:176709559T>A	ENST00000439151.2	+	19	6031	c.5986T>A	c.(5986-5988)Ttc>Atc	p.F1996I	NSD1_ENST00000361032.4_Missense_Mutation_p.F1893I|NSD1_ENST00000354179.4_Missense_Mutation_p.F1727I|NSD1_ENST00000347982.4_Missense_Mutation_p.F1727I	NM_022455.4	NP_071900.2	Q96L73	NSD1_HUMAN	nuclear receptor binding SET domain protein 1	1996	S-adenosyl-L-methionine binding.|SET.				negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	androgen receptor binding|chromatin binding|estrogen receptor binding|histone methyltransferase activity (H3-K36 specific)|histone methyltransferase activity (H4-K20 specific)|ligand-dependent nuclear receptor binding|retinoid X receptor binding|thyroid hormone receptor binding|transcription corepressor activity|zinc ion binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(13)|large_intestine(18)|lung(24)|ovary(2)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(7)|urinary_tract(3)	96	all_cancers(89;1.57e-05)|Renal(175;0.000269)|Lung NSC(126;0.00111)|all_lung(126;0.002)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)|Epithelial(233;0.198)	Kidney(146;0.235)		TATCACTAATTTCTATATGCT	0.378000			T	NUP98	AML		Sotos Syndrome		Weaver syndrome;Sotos syndrome;Beckwith-Wiedemann syndrome	HNSCC(47;0.14)			28	118					0	0	0.693898	0	0
DPYD	1806	broad.mit.edu	37	1	97544538	97544538	+	Silent	SNP	C	C	A			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr1:97544538C>A	ENST00000370192.3	-	23	3172	c.3072G>T	c.(3070-3072)gtG>gtT	p.V1024V		NM_000110.3	NP_000101.2	Q12882	DPYD_HUMAN	dihydropyrimidine dehydrogenase	1024				V -> G (in Ref. 6; AAI31779).	'de novo' pyrimidine base biosynthetic process|purine base catabolic process|thymidine catabolic process|thymine catabolic process|UMP biosynthetic process|uracil catabolic process	cytosol	4 iron, 4 sulfur cluster binding|dihydroorotate oxidase activity|dihydropyrimidine dehydrogenase (NADP+) activity|electron carrier activity|flavin adenine dinucleotide binding|metal ion binding|NADP binding|protein homodimerization activity	p.V1024V(1)		NS(2)|breast(4)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(18)|lung(30)|ovary(4)|prostate(6)|skin(7)|upper_aerodigestive_tract(1)	83		all_epithelial(167;0.000185)|all_lung(203;0.00318)|Lung NSC(277;0.00994)		Colorectal(170;0.0165)|Epithelial(280;0.0526)|all cancers(265;0.104)|READ - Rectum adenocarcinoma(84;0.171)|Lung(183;0.216)	Capecitabine(DB01101)|Enfuvirtide(DB00109)	CACCTTAACACACCGGATTCA	0.408000													4	132					0.00909568	0.00953508	0.150653	1	0
CA12	771	broad.mit.edu	37	15	63637803	63637803	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr15:63637803G>T	ENST00000178638.3	-	4	742	c.302C>A	c.(301-303)cCc>cAc	p.P101H	CA12_ENST00000422263.2_Missense_Mutation_p.P41H|CA12_ENST00000344366.3_Missense_Mutation_p.P101H	NM_001218.3	NP_001209.1	O43570	CAH12_HUMAN	carbonic anhydrase XII	101					one-carbon metabolic process	integral to membrane	carbonate dehydratase activity|zinc ion binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|liver(1)|lung(4)|ovary(1)|prostate(1)|skin(2)	16					Acetazolamide(DB00819)	CATGTCCGAGGGCAGGTTCAG	0.647000													13	14					2.31682e-05	2.53914e-05	0.479597	1	0
BSN	8927	broad.mit.edu	37	3	49689543	49689543	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr3:49689543G>A	ENST00000296452.4	+	5	2668	c.2554G>A	c.(2554-2556)Gcc>Acc	p.A852T		NM_003458.3	NP_003449.2	Q9UPA5	BSN_HUMAN	bassoon presynaptic cytomatrix protein	852					synaptic transmission	cell junction|cytoplasm|cytoskeleton|nucleus|synaptosome	metal ion binding			breast(8)|central_nervous_system(2)|cervix(2)|endometrium(16)|kidney(3)|large_intestine(17)|lung(37)|ovary(7)|pancreas(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	106				BRCA - Breast invasive adenocarcinoma(193;6.66e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.0032)|Kidney(197;0.00336)		CGAGATGAGCGCCGAGGAAGA	0.642000													5	22					0	0	0.217242	0	0
TMEM66	51669	broad.mit.edu	37	8	29927382	29927382	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr8:29927382G>A	ENST00000256255.6	-	3	733	c.476C>T	c.(475-477)tCt>tTt	p.S159F	TMEM66_ENST00000545648.1_5'UTR|TMEM66_ENST00000536273.1_5'UTR	NM_016127.4	NP_057211.4	Q96BY9	TMM66_HUMAN	transmembrane protein 66	159						integral to membrane				endometrium(2)|large_intestine(1)|lung(11)	14				KIRC - Kidney renal clear cell carcinoma(542;0.0993)|Kidney(114;0.119)		ATAATAATCAGAGAAAGAGGC	0.433000													6	87					0	0	0.217242	0	0
RPS18	6222	broad.mit.edu	37	6	33243778	33243778	+	Nonsense_Mutation	SNP	C	C	T			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr6:33243778C>T	ENST00000439602.2	+	4	336	c.226C>T	c.(226-228)Cag>Tag	p.Q76*	RPS18_ENST00000476222.1_3'UTR|RPS18_ENST00000474973.1_Nonsense_Mutation_p.Q6*			P62269	RS18_HUMAN	ribosomal protein S18	76					endocrine pancreas development|ribosome biogenesis|translational elongation|translational termination|viral transcription	cytosolic small ribosomal subunit	rRNA binding|structural constituent of ribosome			kidney(2)|large_intestine(2)|lung(2)|prostate(2)|urinary_tract(1)	9						GAATCCACGCCAGTACAAGAT	0.517000													19	49					0	0	0.575678	0	0
ADAMTS12	81792	broad.mit.edu	37	5	33684008	33684008	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr5:33684008C>A	ENST00000504830.1	-	4	1122	c.787G>T	c.(787-789)Ggg>Tgg	p.G263W	ADAMTS12_ENST00000504582.1_5'UTR|ADAMTS12_ENST00000352040.3_Missense_Mutation_p.G263W	NM_030955.2	NP_112217.2	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 12	263	Peptidase M12B.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(7)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(11)|large_intestine(31)|liver(1)|lung(135)|ovary(4)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(5)	216						TTCTCACTCCCATGGTATTCA	0.512000										HNSCC(64;0.19)			54	84					1.08141e-31	1.38855e-31	0.870114	1	0
RMDN1	51115	broad.mit.edu	37	8	87487184	87487184	+	Splice_Site	SNP	T	T	G			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr8:87487184T>G	ENST00000406452.3	-	9	920		c.e9-2		RMDN1_ENST00000430676.2_Splice_Site|RMDN1_ENST00000523911.1_Intron|RMDN1_ENST00000519966.1_Intron	NM_016033.2	NP_057117.2			regulator of microtubule dynamics 1																		TTGGATCCACTGCACATAAGA	0.333000													6	58					0	0	0.217242	0	0
TTBK1	84630	broad.mit.edu	37	6	43220499	43220499	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr6:43220499G>A	ENST00000259750.4	+	3	214	c.131G>A	c.(130-132)gGc>gAc	p.G44D	TTBK1_ENST00000304139.5_5'UTR	NM_032538.1	NP_115927.1	Q5TCY1	TTBK1_HUMAN	tau tubulin kinase 1	44	Protein kinase.					cell junction|cytoplasm|nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			breast(2)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(10)|liver(1)|lung(21)|ovary(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	53			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0125)|OV - Ovarian serous cystadenocarcinoma(102;0.0399)			GGGGGCGGGGGCTTTGGTGAG	0.587000													24	43					0	0	0.681144	0	0
TMCO3	55002	broad.mit.edu	37	13	114188487	114188487	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr13:114188487A>T	ENST00000434316.2	+	9	1830	c.1471A>T	c.(1471-1473)Atg>Ttg	p.M491L	TMCO3_ENST00000375391.1_Intron|TMCO3_ENST00000474393.1_3'UTR	NM_017905.4	NP_060375.4	Q6UWJ1	TMCO3_HUMAN	transmembrane and coiled-coil domains 3	491						integral to membrane	solute:hydrogen antiporter activity			NS(1)|endometrium(4)|large_intestine(9)|liver(1)|lung(8)|prostate(1)|stomach(1)	25	Lung NSC(43;0.0161)|all_neural(89;0.0337)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.0145)|all_epithelial(44;0.00286)|all_lung(25;0.0273)|Breast(118;0.0411)|Lung NSC(25;0.0983)	all cancers(43;0.0317)			GAAGCTGCACATGGAAAGCAA	0.353000													12	85					0	0	0.387290	0	0
MT-CYB	4519	broad.mit.edu	37	MT	14856	14856	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chrM:14856T>C	ENST00000361789.2	+	1	110	c.110T>C	c.(109-111)cTt>cCt	p.37_37insP						mitochondrially encoded cytochrome b											breast(6)|endometrium(25)|kidney(33)|prostate(1)	65						CGGCTCACTCCTTGGCGCCTG	0.483000													34	402					0	0	0.812448	0	0
ZNF813	126017	broad.mit.edu	37	19	53994808	53994808	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr19:53994808G>C	ENST00000396403.4	+	4	1450	c.1322G>C	c.(1321-1323)tGt>tCt	p.C441S	ZNF813_ENST00000396421.4_Intron	NM_001004301.3	NP_001004301.2	Q6ZN06	ZN813_HUMAN	zinc finger protein 813	441					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)	1				GBM - Glioblastoma multiforme(134;0.00619)		CCCTACAAGTGTACTGAGTGT	0.398000													34	11					0	0	0.819951	0	0
SCN10A	6336	broad.mit.edu	37	3	38739831	38739831	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr3:38739831G>T	ENST00000449082.2	-	27	4879	c.4880C>A	c.(4879-4881)tCc>tAc	p.S1627Y		NM_006514.2	NP_006505.2	Q9Y5Y9	SCNAA_HUMAN	sodium channel, voltage-gated, type X, alpha subunit	1627					sensory perception	voltage-gated sodium channel complex				NS(5)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(14)|kidney(5)|large_intestine(33)|lung(54)|ovary(5)|pancreas(1)|prostate(5)|skin(13)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	150				KIRC - Kidney renal clear cell carcinoma(284;0.0769)|Kidney(284;0.0945)	Benzocaine(DB01086)|Bupivacaine(DB00297)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dibucaine(DB00527)|Dyclonine(DB00645)|Hexylcaine(DB00473)|Levobupivacaine(DB01002)|Lidocaine(DB00281)|Mepivacaine(DB00961)|Oxybuprocaine(DB00892)|Procaine(DB00721)|Proparacaine(DB00807)|Ropivacaine(DB00296)	GGGAAAGCTGGACATACCGAA	0.532000													5	238					0.00116845	0.00124903	0.217242	1	0
ZNF263	10127	broad.mit.edu	37	16	3336081	3336081	+	Missense_Mutation	SNP	A	A	C			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr16:3336081A>C	ENST00000219069.5	+	4	1577	c.701A>C	c.(700-702)cAg>cCg	p.Q234P	ZNF263_ENST00000538765.1_Intron|ZNF263_ENST00000574253.1_Intron|ZNF263_ENST00000573578.1_3'UTR	NM_005741.4	NP_005732.2	O14978	ZN263_HUMAN	zinc finger protein 263	234	KRAB.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|endometrium(2)|large_intestine(4)|lung(5)|ovary(1)|skin(4)|urinary_tract(3)	20						TGGGGGCATCAGGATCCTAGT	0.532000													17	72					0	0	0.557998	0	0
SVIL	6840	broad.mit.edu	37	10	29777571	29777571	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr10:29777571C>T	ENST00000375398.2	-	25	4756	c.4307G>A	c.(4306-4308)aGc>aAc	p.S1436N	SVIL_ENST00000355867.4_Missense_Mutation_p.S1436N|SVIL_ENST00000535393.1_Missense_Mutation_p.S350N|SVIL_ENST00000538146.1_Missense_Mutation_p.S228N|SVIL_ENST00000375400.3_Missense_Mutation_p.S1010N			O95425	SVIL_HUMAN	supervillin	1436	Interaction with NEB.				cytoskeleton organization|skeletal muscle tissue development	cell junction|costamere|invadopodium|nucleus|podosome	actin filament binding			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(17)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(24)|lung(35)|ovary(8)|prostate(2)|skin(4)|stomach(7)|upper_aerodigestive_tract(2)|urinary_tract(2)	112		Breast(68;0.103)				GGGCACGGCGCTGTTGTTAGA	0.532000													3	11					0	0	0.115264	0	0
USP1	7398	broad.mit.edu	37	1	62908992	62908992	+	Splice_Site	SNP	T	T	C			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr1:62908992T>C	ENST00000339950.4	+	5	1372		c.e5+2		USP1_ENST00000371146.1_Splice_Site	NM_003368.4	NP_003359.3	O94782	UBP1_HUMAN	ubiquitin specific peptidase 1						DNA repair|monoubiquitinated protein deubiquitination|regulation of DNA repair|response to UV|ubiquitin-dependent protein catabolic process	nucleoplasm	cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			breast(2)|kidney(1)|large_intestine(1)|lung(10)|ovary(2)|prostate(2)|stomach(1)	19		all_neural(321;0.0281)		BRCA - Breast invasive adenocarcinoma(111;8.01e-05)|KIRC - Kidney renal clear cell carcinoma(1967;0.00245)|OV - Ovarian serous cystadenocarcinoma(397;0.0535)		CACACTGAGGTATAGCCTATA	0.393000													3	21					0	0	0.115264	0	0
MUC17	140453	broad.mit.edu	37	7	100678546	100678546	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr7:100678546A>G	ENST00000306151.4	+	3	3913	c.3849A>G	c.(3847-3849)atA>atG	p.I1283M		NM_001040105.1	NP_001035194.1	Q685J3	MUC17_HUMAN	mucin 17, cell surface associated	1283	59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			NS(3)|breast(14)|central_nervous_system(2)|cervix(2)|endometrium(27)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(28)|lung(179)|ovary(19)|pancreas(1)|prostate(13)|skin(26)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	343	Lung NSC(181;0.136)|all_lung(186;0.182)					TAACAAGTATACCTGTCAGCA	0.473000													49	142					0	0	0.870114	0	0
F7	2155	broad.mit.edu	37	13	113772899	113772899	+	Silent	SNP	G	G	C			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr13:113772899G>C	ENST00000375581.3	+	9	1013	c.978G>C	c.(976-978)cgG>cgC	p.R326R	F7_ENST00000346342.3_Silent_p.R304R|F7_ENST00000541084.1_Silent_p.R257R	NM_000131.4	NP_000122.1	P08709	FA7_HUMAN	coagulation factor VII (serum prothrombin conversion accelerator)	326	Peptidase S1.		R -> Q (in FA7D).		anti-apoptosis|blood coagulation, extrinsic pathway|peptidyl-glutamic acid carboxylation|positive regulation of leukocyte chemotaxis|positive regulation of platelet-derived growth factor receptor signaling pathway|positive regulation of positive chemotaxis|positive regulation of protein kinase B signaling cascade|post-translational protein modification|proteolysis	endoplasmic reticulum lumen|Golgi lumen|plasma membrane	calcium ion binding|glycoprotein binding|serine-type endopeptidase activity			large_intestine(4)|lung(9)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	16	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)	all_cancers(25;0.118)|all_lung(25;0.0364)|all_epithelial(44;0.0393)|Lung NSC(25;0.128)|Breast(118;0.188)	all cancers(43;0.0737)|Epithelial(84;0.213)|BRCA - Breast invasive adenocarcinoma(86;0.218)		Coagulation Factor IX(DB00100)|Coagulation factor VIIa(DB00036)|Menadione(DB00170)	TGCCCGAACGGACGTTCTCTG	0.682000													2	5					0	0	0.115264	0	0
RPS6KC1	26750	broad.mit.edu	37	1	213414788	213414788	+	Nonsense_Mutation	SNP	C	C	T			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr1:213414788C>T	ENST00000366960.3	+	11	2119	c.1969C>T	c.(1969-1971)Cag>Tag	p.Q657*	RPS6KC1_ENST00000543354.1_Nonsense_Mutation_p.Q360*|RPS6KC1_ENST00000490299.1_3'UTR|RPS6KC1_ENST00000366959.3_Nonsense_Mutation_p.Q645*|RPS6KC1_ENST00000543470.1_Nonsense_Mutation_p.Q445*	NM_012424.3	NP_036556.2	Q96S38	KS6C1_HUMAN	ribosomal protein S6 kinase, 52kDa, polypeptide 1	657					cell communication|signal transduction	early endosome|membrane	ATP binding|phosphatidylinositol binding|protein binding|protein serine/threonine kinase activity			breast(1)|endometrium(6)|kidney(4)|large_intestine(8)|liver(2)|lung(15)|ovary(3)|prostate(1)|urinary_tract(3)	43				OV - Ovarian serous cystadenocarcinoma(81;0.00705)|all cancers(67;0.016)|GBM - Glioblastoma multiforme(131;0.0663)|Epithelial(68;0.145)		GTTTAAAGCTCAGGACACCAT	0.403000													40	93					0	0	0.827153	0	0
MT-ND4	4538	broad.mit.edu	37	MT	11213	11213	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chrM:11213T>C	ENST00000361381.2	+	1	454	c.454T>C	c.(454-456)Tac>Cac	p.152_152insH						mitochondrially encoded NADH dehydrogenase 4											breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|prostate(1)	13						ACTTCCTATTCTACACCCTAG	0.483000													4	497					0	0	0.217242	0	0
SHISA2	387914	broad.mit.edu	37	13	26620732	26620732	+	Silent	SNP	C	C	T			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr13:26620732C>T	ENST00000319420.3	-	2	862	c.807G>A	c.(805-807)ctG>ctA	p.L269L		NM_001007538.1	NP_001007539.1	Q6UWI4	SHSA2_HUMAN	shisa family member 2	269					multicellular organismal development	endoplasmic reticulum membrane|integral to membrane		p.L269L(1)		central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(7)|ovary(1)|prostate(2)|skin(1)	17						AGCCAGGCTGCAGGCCGTCCA	0.572000													9	41					0	0	0.387290	0	0
GXYLT1	283464	broad.mit.edu	37	12	42491397	42491397	+	Silent	SNP	C	C	A			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr12:42491397C>A	ENST00000398675.3	-	7	1240	c.1008G>T	c.(1006-1008)ccG>ccT	p.P336P	GXYLT1_ENST00000280876.6_Silent_p.P305P	NM_001099650.1|NM_173601.1	NP_001093120.1|NP_775872.1	Q4G148	GXLT1_HUMAN	glucoside xylosyltransferase 1	336					O-glycan processing	integral to membrane	UDP-xylosyltransferase activity			kidney(2)|large_intestine(4)|liver(3)|lung(8)	17						TCCATTGACACGGAAAAACAA	0.348000													38	64					7.04047e-22	8.73019e-22	0.812448	1	0
DMWD	1762	broad.mit.edu	37	19	46289604	46289604	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr19:46289604C>G	ENST00000270223.6	-	3	1195	c.1150G>C	c.(1150-1152)Gag>Cag	p.E384Q	DMWD_ENST00000377735.3_Missense_Mutation_p.E384Q	NM_004943.1	NP_004934.1	Q09019	DMWD_HUMAN	dystrophia myotonica, WD repeat containing	384					meiosis					central_nervous_system(1)|endometrium(2)|large_intestine(5)|lung(6)|prostate(1)|upper_aerodigestive_tract(1)	16		Ovarian(192;0.0308)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.00604)|GBM - Glioblastoma multiforme(486;0.0807)|Epithelial(262;0.236)		GCCGCCTCCTCTGCCCTTGTG	0.711000													4	42					0	0	0.150653	0	0
FNTA	2339	broad.mit.edu	37	8	42927367	42927367	+	Nonsense_Mutation	SNP	C	C	T			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr8:42927367C>T	ENST00000529687.1	+	5	985	c.97C>T	c.(97-99)Cag>Tag	p.Q33*	RP11-598P20.5_ENST00000534420.1_Nonsense_Mutation_p.Q141*|FNTA_ENST00000342116.4_Nonsense_Mutation_p.Q117*|FNTA_ENST00000302279.3_Nonsense_Mutation_p.Q184*			P49354	FNTA_HUMAN	farnesyltransferase, CAAX box, alpha	184					cellular component disassembly involved in apoptosis|positive regulation of deacetylase activity|positive regulation of tubulin deacetylation|protein farnesylation|protein geranylgeranylation|transforming growth factor beta receptor signaling pathway	cytosol|microtubule associated complex	alpha-tubulin binding|CAAX-protein geranylgeranyltransferase activity|microtubule binding|protein farnesyltransferase activity	p.Q184E(1)		cervix(1)|endometrium(2)|large_intestine(1)|liver(1)|lung(8)|ovary(1)|prostate(1)|urinary_tract(1)	16	Prostate(17;0.0119)|Ovarian(28;0.0172)|Lung SC(25;0.184)	all_cancers(86;0.000223)|all_epithelial(80;1.61e-07)|all_lung(54;0.00021)|Lung NSC(58;0.000778)|Hepatocellular(245;0.0524)|Renal(179;0.0822)|Esophageal squamous(32;0.129)	Lung(22;0.0777)|LUSC - Lung squamous cell carcinoma(45;0.17)			AGATCCATCTCAGGAGCTTGA	0.378000													6	69					0	0	0.217242	0	0
CACNA1S	779	broad.mit.edu	37	1	201047024	201047024	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr1:201047024C>A	ENST00000362061.3	-	11	1828	c.1602G>T	c.(1600-1602)agG>agT	p.R534S	CACNA1S_ENST00000367338.3_Missense_Mutation_p.R534S	NM_000069.2	NP_000060.2	Q13698	CAC1S_HUMAN	calcium channel, voltage-dependent, L type, alpha 1S subunit	534					axon guidance	I band|T-tubule|voltage-gated calcium channel complex	high voltage-gated calcium channel activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(13)|large_intestine(19)|lung(37)|ovary(6)|prostate(3)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	102					Magnesium Sulfate(DB00653)|Verapamil(DB00661)	TCTTGAAGATCCTCAGGAGGC	0.632000													16	25					4.75885e-15	5.80152e-15	0.520397	1	0
CRB1	23418	broad.mit.edu	37	1	197404462	197404462	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr1:197404462A>T	ENST00000367397.1	+	5	2470	c.1612A>T	c.(1612-1614)Atc>Ttc	p.I538F	CRB1_ENST00000544212.1_Missense_Mutation_p.I638F|CRB1_ENST00000535699.1_Missense_Mutation_p.I1133F|CRB1_ENST00000367400.3_Missense_Mutation_p.I1157F|CRB1_ENST00000538660.1_Intron|CRB1_ENST00000367399.2_Missense_Mutation_p.I1045F			P82279	CRUM1_HUMAN	crumbs homolog 1 (Drosophila)	1157	Laminin G-like 1.				cell-cell signaling|establishment or maintenance of cell polarity	apical plasma membrane|extracellular region|integral to membrane	calcium ion binding|protein binding			NS(1)|breast(4)|central_nervous_system(2)|cervix(3)|endometrium(13)|kidney(4)|large_intestine(21)|lung(58)|ovary(7)|prostate(3)|skin(10)|upper_aerodigestive_tract(4)|urinary_tract(2)	132						CTGTGAAGACATCTATAGCTC	0.443000													32	44					0	0	0.769981	0	0
PPM1H	57460	broad.mit.edu	37	12	63195774	63195774	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr12:63195774C>A	ENST00000228705.6	-	3	878	c.578G>T	c.(577-579)gGg>gTg	p.G193V		NM_020700.1	NP_065751.1	Q9ULR3	PPM1H_HUMAN	protein phosphatase, Mg2+/Mn2+ dependent, 1H	193	PP2C-like.						phosphoprotein phosphatase activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(9)|ovary(1)	18			GBM - Glioblastoma multiforme(1;0.000443)|BRCA - Breast invasive adenocarcinoma(9;0.209)	GBM - Glioblastoma multiforme(28;0.0126)		AGGCTCCTCCCCCAGGCAGGT	0.716000													14	28					1.52009e-12	1.82243e-12	0.479597	1	0
FOXB1	27023	broad.mit.edu	37	15	60297453	60297453	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr15:60297453C>G	ENST00000396057.4	+	2	770	c.291C>G	c.(289-291)ttC>ttG	p.F97L	FOXB1_ENST00000560857.1_Intron	NM_012182.2	NP_036314.2	Q99853	FOXB1_HUMAN	forkhead box B1	97					axon target recognition|cell migration in diencephalon|epithelial cell differentiation involved in mammary gland alveolus development|floor plate development|hypothalamus cell migration|inferior colliculus development|lactation|mammillothalamic axonal tract development|negative regulation of neuron apoptosis|regulation of sequence-specific DNA binding transcription factor activity|somitogenesis|telencephalon cell migration|visual learning	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			central_nervous_system(1)|kidney(1)|lung(3)|ovary(1)	6						GGGACATGTTCGAGAACGGCA	0.662000													19	18					0	0	0.575678	0	0
UBR2	23304	broad.mit.edu	37	6	42627405	42627405	+	Nonsense_Mutation	SNP	C	C	G			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr6:42627405C>G	ENST00000372899.1	+	30	3512	c.3254C>G	c.(3253-3255)tCa>tGa	p.S1085*	UBR2_ENST00000372901.1_Nonsense_Mutation_p.S1085*|UBR2_ENST00000372883.3_3'UTR	NM_015255.2	NP_056070.1	Q8IWV8	UBR2_HUMAN	ubiquitin protein ligase E3 component n-recognin 2	1085					cellular response to leucine|chromatin silencing|histone H2A ubiquitination|negative regulation of TOR signaling cascade	nucleus|plasma membrane	leucine binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(10)|kidney(7)|large_intestine(14)|lung(22)|ovary(3)|pancreas(1)|skin(5)	64	Colorectal(47;0.196)		Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)|all cancers(41;0.004)|KIRC - Kidney renal clear cell carcinoma(15;0.02)|Kidney(15;0.0388)|OV - Ovarian serous cystadenocarcinoma(102;0.196)			CCTGTGGCTTCAGATATGACA	0.388000													15	25					0	0	0.575678	0	0
COL8A1	1295	broad.mit.edu	37	3	99509625	99509625	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr3:99509625C>G	ENST00000261037.3	+	4	479	c.99C>G	c.(97-99)atC>atG	p.I33M	COL8A1_ENST00000273342.4_Missense_Mutation_p.I33M	NM_001850.4	NP_001841.2	P27658	CO8A1_HUMAN	collagen, type VIII, alpha 1	33	Nonhelical region (NC2).				angiogenesis|cell adhesion	basement membrane|collagen type VIII				breast(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(15)|skin(5)|upper_aerodigestive_tract(1)	27						ACTATGGGATCAAGCCGCTGC	0.552000													11	51					0	0	0.435327	0	0
COL5A2	1290	broad.mit.edu	37	2	189914110	189914110	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr2:189914110G>T	ENST00000374866.3	-	44	3384	c.3110C>A	c.(3109-3111)cCa>cAa	p.P1037Q		NM_000393.3	NP_000384.2	P05997	CO5A2_HUMAN	collagen, type V, alpha 2	1037					axon guidance|collagen fibril organization|eye morphogenesis|skin development	collagen type V	extracellular matrix structural constituent			NS(3)|breast(2)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(16)|lung(53)|ovary(3)|prostate(2)|skin(6)|urinary_tract(3)	95			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.127)			ATTGGAGCCTGGGGGCCCCAC	0.453000													14	17					0.000308642	0.00033321	0.479597	1	0
CAPN3	825	broad.mit.edu	37	15	42689048	42689048	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr15:42689048A>T	ENST00000397163.3	+	9	1385	c.1166A>T	c.(1165-1167)cAc>cTc	p.H389L	RP11-164J13.1_ENST00000495723.1_RNA|CAPN3_ENST00000318023.7_Missense_Mutation_p.H389L|CAPN3_ENST00000356316.3_Missense_Mutation_p.H302L|CAPN3_ENST00000357568.3_Missense_Mutation_p.H389L|CAPN3_ENST00000349748.3_Missense_Mutation_p.H341L	NM_000070.2	NP_000061.1	P20807	CAN3_HUMAN	calpain 3, (p94)	389	Calpain catalytic.				muscle organ development|proteolysis	cytoplasm	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity|signal transducer activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(8)|lung(21)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	47		all_cancers(109;1.65e-16)|all_epithelial(112;8.34e-15)|Lung NSC(122;3.56e-09)|all_lung(180;1.68e-08)|Melanoma(134;0.0574)|Colorectal(260;0.152)		GBM - Glioblastoma multiforme(94;7.36e-07)		CGTCTGCAGCACCAGGTCACT	0.542000													17	32					0	0	0.557998	0	0
IVL	3713	broad.mit.edu	37	1	152883981	152883981	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr1:152883981G>A	ENST00000368764.3	+	2	1772	c.1708G>A	c.(1708-1710)Gag>Aag	p.E570K	IVL_ENST00000392667.2_Missense_Mutation_p.E424K			P07476	INVO_HUMAN	involucrin	570					isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine|keratinization|response to UV-B	cornified envelope|cytoplasm	protein binding, bridging|structural molecule activity			breast(1)|endometrium(6)|kidney(1)|large_intestine(5)|lung(11)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)	29	Lung NSC(65;3.97e-29)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.171)			GCTTCCTGTAGAGCACCAGCA	0.567000													7	282					0	0	0.335167	0	0
SPATA31E1	286234	broad.mit.edu	37	9	90502913	90502913	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr9:90502913C>A	ENST00000325643.5	+	4	3577	c.3511C>A	c.(3511-3513)Cta>Ata	p.L1171I		NM_178828.4	NP_849150.3			SPATA31 subfamily E, member 1																		ATGTGCCCTCCTATGGAAGGG	0.622000													13	14					5.50884e-06	6.16195e-06	0.411799	1	0
STMN1	3925	broad.mit.edu	37	1	26227995	26227995	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr1:26227995C>G	ENST00000399728.1	-	4	728	c.365G>C	c.(364-366)cGt>cCt	p.R122P	STMN1_ENST00000465604.1_5'UTR|STMN1_ENST00000455785.2_Missense_Mutation_p.R122P|STMN1_ENST00000374291.1_Missense_Mutation_p.R122P|STMN1_ENST00000357865.2_Missense_Mutation_p.R122P|STMN1_ENST00000426559.2_Missense_Mutation_p.R122P	NM_203401.1	NP_981946.1	P16949	STMN1_HUMAN	stathmin 1	122					cell differentiation|intracellular signal transduction|microtubule depolymerization|mitotic spindle organization|nervous system development|response to virus	cytoplasm|microtubule	signal transducer activity|tubulin binding			breast(2)|large_intestine(2)|skin(2)	6		Colorectal(325;3.46e-05)|Lung NSC(340;0.000163)|all_lung(284;0.000234)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0155)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0505)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;1.85e-25)|Colorectal(126;2.96e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.000716)|BRCA - Breast invasive adenocarcinoma(304;0.000946)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.013)|READ - Rectum adenocarcinoma(331;0.0649)		CTCTCGCAAACGTTCCAGTTT	0.418000													35	58					0	0	0.804634	0	0
IFT74	80173	broad.mit.edu	37	9	27016972	27016972	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr9:27016972C>G	ENST00000443698.1	+	11	1028	c.857C>G	c.(856-858)tCc>tGc	p.S286C	IFT74_ENST00000429045.2_Missense_Mutation_p.S286C|IFT74_ENST00000433700.1_Missense_Mutation_p.S286C|IFT74_ENST00000380062.5_Missense_Mutation_p.S286C	NM_001099222.1	NP_001092692.1	Q96LB3	IFT74_HUMAN	intraflagellar transport 74 homolog (Chlamydomonas)	286						cytoplasmic membrane-bounded vesicle|intraflagellar transport particle B|microtubule-based flagellum				endometrium(1)|large_intestine(1)|lung(2)|prostate(1)|skin(1)	6		all_neural(11;2.36e-10)		Lung(218;1.4e-05)|LUSC - Lung squamous cell carcinoma(38;0.000114)		GAGTTGGAGTCCCATCGAGAT	0.383000													4	46					0	0	0.184627	0	0
RB1	5925	broad.mit.edu	37	13	48916812	48916812	+	Silent	SNP	G	G	T			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr13:48916812G>T	ENST00000267163.4	+	3	480	c.342G>T	c.(340-342)tcG>tcT	p.S114S		NM_000321.2	NP_000312.2	P06400	RB_HUMAN	retinoblastoma 1	114					androgen receptor signaling pathway|cell cycle arrest|chromatin remodeling|G1 phase of mitotic cell cycle|interspecies interaction between organisms|maintenance of mitotic sister chromatid cohesion|mitotic cell cycle G1/S transition checkpoint|myoblast differentiation|negative regulation of cell growth|negative regulation of protein kinase activity|negative regulation of S phase of mitotic cell cycle|negative regulation of sequence-specific DNA binding transcription factor activity|positive regulation of mitotic metaphase/anaphase transition|protein localization to chromosome, centromeric region|Ras protein signal transduction|regulation of centromere complex assembly|regulation of cohesin localization to chromatin|regulation of lipid kinase activity|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle|sister chromatid biorientation	chromatin|PML body|Rb-E2F complex|SWI/SNF complex	androgen receptor binding|DNA binding|kinase binding|phosphoprotein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription factor binding|ubiquitin protein ligase binding	p.0?(15)|p.?(5)		NS(3)|adrenal_gland(1)|bone(22)|breast(30)|central_nervous_system(48)|cervix(3)|endometrium(14)|eye(95)|gastrointestinal_tract_(site_indeterminate)(1)|haematopoietic_and_lymphoid_tissue(20)|kidney(3)|large_intestine(10)|liver(3)|lung(153)|oesophagus(1)|ovary(13)|pancreas(5)|pituitary(1)|prostate(14)|salivary_gland(2)|skin(9)|soft_tissue(9)|stomach(4)|upper_aerodigestive_tract(1)|urinary_tract(31)	496		all_cancers(8;6.9e-71)|all_epithelial(8;4.61e-22)|Acute lymphoblastic leukemia(8;1.1e-21)|all_hematologic(8;2.3e-21)|all_lung(13;1.51e-09)|Lung NSC(96;7.03e-07)|Breast(56;1.53e-05)|Prostate(109;0.000493)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|all_neural(104;0.0227)|Glioma(44;0.0286)|Lung SC(185;0.0301)		GBM - Glioblastoma multiforme(2;9.98e-18)|LUSC - Lung squamous cell carcinoma(3;0.013)	Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	ATGAGATGTCGTTCACTTTTA	0.348000		6	"""D, Mis, N, F, S"""		"""retinoblastoma, sarcoma, breast, small cell lung"""	"""retinoblastoma, sarcoma, breast, small cell lung"""			Hereditary Retinoblastoma	TCGA GBM(7;6.82e-08)|TSP Lung(12;0.097)|TCGA Ovarian(6;0.080)			29	42					3.73148e-12	4.42476e-12	0.717897	1	0
FN1	2335	broad.mit.edu	37	2	216273069	216273069	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr2:216273069A>G	ENST00000354785.4	-	16	2749	c.2380T>C	c.(2380-2382)Tct>Cct	p.S794P	FN1_ENST00000421182.1_Missense_Mutation_p.S794P|FN1_ENST00000356005.4_Missense_Mutation_p.S794P|FN1_ENST00000443816.1_Missense_Mutation_p.S794P|FN1_ENST00000359671.1_Missense_Mutation_p.S794P|FN1_ENST00000357867.4_Missense_Mutation_p.S794P|FN1_ENST00000446046.1_Missense_Mutation_p.S794P|FN1_ENST00000323926.6_Missense_Mutation_p.S794P|FN1_ENST00000357009.2_Missense_Mutation_p.S794P|FN1_ENST00000345488.5_Missense_Mutation_p.S794P|FN1_ENST00000336916.4_Missense_Mutation_p.S794P|FN1_ENST00000432072.2_Missense_Mutation_p.S794P|FN1_ENST00000346544.3_Missense_Mutation_p.S794P			P02751	FINC_HUMAN	fibronectin 1	794	Fibronectin type-III 2.				acute-phase response|angiogenesis|leukocyte migration|peptide cross-linking|platelet activation|platelet degranulation|regulation of cell shape|substrate adhesion-dependent cell spreading	ER-Golgi intermediate compartment|fibrinogen complex|platelet alpha granule lumen|proteinaceous extracellular matrix	collagen binding|extracellular matrix structural constituent|heparin binding		FN1/ALK(2)	NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(7)|endometrium(9)|kidney(8)|large_intestine(33)|lung(38)|ovary(1)|pancreas(1)|prostate(3)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)	109		Renal(323;0.127)		Epithelial(149;9.59e-07)|all cancers(144;0.000174)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)	Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	CCATCCTCAGATATCTGATAG	0.403000													19	105					0	0	0.592651	0	0
RBM15	64783	broad.mit.edu	37	1	110888219	110888219	+	Silent	SNP	G	G	A			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr1:110888219G>A	ENST00000369784.3	+	2	3822	c.2922G>A	c.(2920-2922)ctG>ctA	p.L974L	RBM15_ENST00000487146.2_Intron	NM_022768.4	NP_073605.4	Q96T37	RBM15_HUMAN	RNA binding motif protein 15	974					interspecies interaction between organisms	nucleus	nucleotide binding|protein binding|RNA binding			ovary(3)	3		all_cancers(81;2.89e-06)|all_epithelial(167;2.96e-06)|all_lung(203;0.000116)|Lung NSC(277;0.000233)|Breast(1374;0.0634)		BRCA - Breast invasive adenocarcinoma(282;0.000224)|Epithelial(280;0.000476)|Kidney(133;0.000539)|KIRC - Kidney renal clear cell carcinoma(1967;0.000716)|all cancers(265;0.00144)|Lung(183;0.0238)|Colorectal(144;0.103)|LUSC - Lung squamous cell carcinoma(189;0.135)		ACTTGGCGCTGACCCTGTTAT	0.393000			T	MKL1	acute megakaryocytic leukemia								5	206					0	0	0.184627	0	0
TRIL	9865	broad.mit.edu	37	7	28997432	28997432	+	RNA	SNP	G	G	A			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr7:28997432G>A	ENST00000322982.3	-	0	502				AC005013.5_ENST00000436594.1_lincRNA			Q7L0X0	TRIL_HUMAN	TLR4 interactor with leucine-rich repeats						inflammatory response|innate immune response|regulation of cytokine production involved in immune response|toll-like receptor 4 signaling pathway	lipopolysaccharide receptor complex	lipopolysaccharide binding										GGTGGAAGTCGAAGGCCGTGA	0.637000													5	25					0	0	0.217242	0	0
ATXN2	6311	broad.mit.edu	37	12	111923112	111923112	+	Silent	SNP	C	C	T			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr12:111923112C>T	ENST00000377617.3	-	18	3122	c.2961G>A	c.(2959-2961)acG>acA	p.T987T	ATXN2_ENST00000550104.1_Intron|ATXN2_ENST00000542287.2_Silent_p.T722T|ATXN2_ENST00000389153.4_Silent_p.T722T|ATXN2_ENST00000535949.1_Silent_p.T698T	NM_002973.3	NP_002964.3	Q99700	ATX2_HUMAN	ataxin 2	987	Pro-rich.				cell death|cytoplasmic mRNA processing body assembly|regulation of translation|RNA metabolic process|RNA transport|stress granule assembly	nucleus|perinuclear region of cytoplasm|polysome|stress granule|trans-Golgi network	protein C-terminus binding|RNA binding			NS(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(6)|kidney(5)|large_intestine(8)|lung(6)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	37						CTGGCATGGGCGTCATAGGTA	0.363000													19	138					0	0	0.557998	0	0
WBSCR17	64409	broad.mit.edu	37	7	70880904	70880904	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr7:70880904G>T	ENST00000333538.5	+	4	1253	c.619G>T	c.(619-621)Gtc>Ttc	p.V207F	WBSCR17_ENST00000498380.2_3'UTR	NM_022479.1	NP_071924.1	Q6IS24	GLTL3_HUMAN	Williams-Beuren syndrome chromosome region 17	207	Catalytic subdomain A.					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			NS(5)|breast(2)|central_nervous_system(1)|endometrium(7)|kidney(7)|large_intestine(22)|lung(45)|ovary(2)|pancreas(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)	100		all_cancers(73;0.2)|Lung NSC(55;0.094)|all_lung(88;0.125)				AGAGGAGTATGTCCACAAACG	0.507000													8	25					1.12685e-05	1.25398e-05	0.307466	1	0
MED23	9439	broad.mit.edu	37	6	131943069	131943069	+	Silent	SNP	A	A	T			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr6:131943069A>T	ENST00000403834.3	-	6	620	c.447T>A	c.(445-447)ccT>ccA	p.P149P	MED23_ENST00000539158.1_Silent_p.P149P|MED23_ENST00000368058.1_Silent_p.P149P|MED23_ENST00000354577.4_Silent_p.P149P|MED23_ENST00000540546.1_Silent_p.P149P|MED23_ENST00000368060.3_Silent_p.P149P|MED23_ENST00000368068.3_Silent_p.P149P|MED23_ENST00000368053.4_Silent_p.P149P			Q9ULK4	MED23_HUMAN	mediator complex subunit 23	149					regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	transcription factor complex	protein binding|transcription coactivator activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(12)|lung(15)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	44	Breast(56;0.0753)			GBM - Glioblastoma multiforme(226;0.0115)|OV - Ovarian serous cystadenocarcinoma(155;0.0608)		TCACTGTATTAGGAATTGTCA	0.368000													14	83					0	0	0.592651	0	0
IL1RAPL2	26280	broad.mit.edu	37	X	105010959	105010959	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chrX:105010959T>C	ENST00000372582.1	+	11	2122	c.1366T>C	c.(1366-1368)Tac>Cac	p.Y456H	IL1RAPL2_ENST00000538500.1_Missense_Mutation_p.Y61H|IL1RAPL2_ENST00000344799.4_Missense_Mutation_p.Y456H	NM_017416.1	NP_059112.1	Q9NP60	IRPL2_HUMAN	interleukin 1 receptor accessory protein-like 2	456	TIR.				central nervous system development|innate immune response	integral to membrane	interleukin-1, Type II, blocking receptor activity			breast(3)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(14)|lung(23)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	49						ATTTGTAGCATACATGGAAGA	0.388000													5	17					0	0	0.248553	0	0
EIF2AK1	27102	broad.mit.edu	37	7	6084286	6084286	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr7:6084286G>A	ENST00000199389.6	-	7	783	c.637C>T	c.(637-639)Cgg>Tgg	p.R213W	EIF2AK1_ENST00000536084.1_Missense_Mutation_p.R89W|EIF2AK1_ENST00000495565.1_5'UTR	NM_001134335.1|NM_014413.3	NP_001127807.1|NP_055228.2	Q9BQI3	E2AK1_HUMAN	eukaryotic translation initiation factor 2-alpha kinase 1	213	Protein kinase.				negative regulation of hemoglobin biosynthetic process|negative regulation of translational initiation by iron|protein autophosphorylation|response to external stimulus|response to stress	cytoplasm	ATP binding|eukaryotic translation initiation factor 2alpha kinase activity|heme binding|protein homodimerization activity			central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(10)|prostate(1)|skin(1)|stomach(3)|upper_aerodigestive_tract(2)	27		Ovarian(82;0.0423)		UCEC - Uterine corpus endometrioid carcinoma (126;0.106)|OV - Ovarian serous cystadenocarcinoma(56;5.22e-14)		TTCACTTCCCGTAGGACCTAG	0.448000													7	26					0	0	0.278610	0	0
KCNT2	343450	broad.mit.edu	37	1	196300311	196300311	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr1:196300311G>A	ENST00000367433.5	-	18	2179	c.2078C>T	c.(2077-2079)cCa>cTa	p.P693L	KCNT2_ENST00000294725.8_Missense_Mutation_p.P693L|KCNT2_ENST00000367431.4_Missense_Mutation_p.P643L|KCNT2_ENST00000498426.1_5'UTR|KCNT2_ENST00000451324.2_Missense_Mutation_p.P304L			Q6UVM3	KCNT2_HUMAN	potassium channel, subfamily T, member 2	693						voltage-gated potassium channel complex	ATP binding|calcium-activated potassium channel activity|voltage-gated potassium channel activity			NS(1)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(16)|lung(43)|ovary(5)|pancreas(1)|prostate(1)|skin(11)|stomach(2)|upper_aerodigestive_tract(1)	97						GCAGCAAAATGGTACTTTTTC	0.279000													5	257					0	0	0.184627	0	0
RNF103	7844	broad.mit.edu	37	2	86831094	86831094	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr2:86831094G>A	ENST00000237455.4	-	4	2898	c.1930C>T	c.(1930-1932)Cat>Tat	p.H644Y	RNF103-CHMP3_ENST00000604011.1_Intron|CHMP3_ENST00000439940.2_Intron|AC015971.2_ENST00000597638.1_RNA|AC015971.2_ENST00000439077.1_RNA	NM_001198951.1|NM_005667.3	NP_001185880.1|NP_005658.1	O00237	RN103_HUMAN	ring finger protein 103	644					central nervous system development|ER-associated protein catabolic process	endoplasmic reticulum membrane|integral to membrane	protein binding|ubiquitin-protein ligase activity|zinc ion binding			central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(7)|lung(7)|skin(2)	25						CAATTCTGATGAAACACATGA	0.453000													6	218					0	0	0.278610	0	0
GPRC6A	222545	broad.mit.edu	37	6	117121856	117121856	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr6:117121856T>C	ENST00000310357.3	-	4	1460	c.1439A>G	c.(1438-1440)aAg>aGg	p.K480R	GPRC6A_ENST00000368549.3_Intron|GPRC6A_ENST00000530250.1_Missense_Mutation_p.K305R	NM_148963.2	NP_683766.2	Q5T6X5	GPC6A_HUMAN	G protein-coupled receptor, family C, group 6, member A	480					response to amino acid stimulus		G-protein coupled receptor activity			autonomic_ganglia(1)|breast(4)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(8)|liver(1)|lung(24)|ovary(5)|pancreas(1)|skin(5)|stomach(3)|upper_aerodigestive_tract(3)	65		all_cancers(87;0.0314)|all_epithelial(87;0.0216)|Colorectal(196;0.234)		GBM - Glioblastoma multiforme(226;0.0265)|all cancers(137;0.0554)|OV - Ovarian serous cystadenocarcinoma(136;0.07)		ATTGATCTCCTTCCAGAGCAC	0.393000													52	55					0	0	0.870114	0	0
PXDNL	137902	broad.mit.edu	37	8	52321349	52321349	+	Silent	SNP	C	C	T			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr8:52321349C>T	ENST00000356297.4	-	17	2935	c.2835G>A	c.(2833-2835)gcG>gcA	p.A945A	PXDNL_ENST00000543296.1_Silent_p.A945A	NM_144651.4	NP_653252.3	A1KZ92	PXDNL_HUMAN	peroxidasin homolog (Drosophila)-like	945					hydrogen peroxide catabolic process	extracellular space	heme binding|peroxidase activity			NS(1)|breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(6)|lung(25)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	48		all_cancers(86;0.107)|Lung NSC(129;0.00641)|all_epithelial(80;0.00716)|all_lung(136;0.015)				GCTCCTGTCGCGCGCACTCGG	0.647000													4	6					0	0	0.217242	0	0
NAMPT	10135	broad.mit.edu	37	7	105903950	105903950	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr7:105903950G>C	ENST00000222553.3	-	7	1164	c.857C>G	c.(856-858)gCg>gGg	p.A286G	NAMPT_ENST00000354289.4_Missense_Mutation_p.A286G	NM_005746.2	NP_005737.1	P43490	NAMPT_HUMAN	nicotinamide phosphoribosyltransferase	286					cell-cell signaling|NAD biosynthetic process|nicotinamide metabolic process|positive regulation of cell proliferation|positive regulation of nitric-oxide synthase biosynthetic process|signal transduction|water-soluble vitamin metabolic process	cytosol	cytokine activity|nicotinamide phosphoribosyltransferase activity|nicotinate phosphoribosyltransferase activity|nicotinate-nucleotide diphosphorylase (carboxylating) activity	p.A286V(1)		endometrium(2)|kidney(1)|large_intestine(4)|lung(5)|prostate(1)|upper_aerodigestive_tract(1)	14						TTTCTCACACGCATTATAAAT	0.388000													12	45					0	0	0.387290	0	0
LRP2	4036	broad.mit.edu	37	2	170012818	170012818	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr2:170012818C>G	ENST00000263816.3	-	65	12402	c.12117G>C	c.(12115-12117)atG>atC	p.M4039I		NM_004525.2	NP_004516.2	P98164	LRP2_HUMAN	low density lipoprotein receptor-related protein 2	4039	EGF-like 15; calcium-binding (Potential).				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding	p.M4039I(1)		biliary_tract(1)|breast(16)|central_nervous_system(6)|cervix(2)|endometrium(24)|haematopoietic_and_lymphoid_tissue(2)|kidney(17)|large_intestine(70)|liver(1)|lung(117)|ovary(19)|pancreas(1)|prostate(2)|skin(17)|upper_aerodigestive_tract(7)|urinary_tract(13)	315				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	GGCGGTCACTCATAGACGTGA	0.433000													21	86					0	0	0.624587	0	0
MYLK	4638	broad.mit.edu	37	3	123345716	123345716	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr3:123345716C>A	ENST00000360772.3	-	31	5412	c.5034G>T	c.(5032-5034)aaG>aaT	p.K1678N	MYLK_ENST00000475616.1_Missense_Mutation_p.K1729N|MYLK_ENST00000360304.3_Missense_Mutation_p.K1729N|MYLK_ENST00000359169.1_Missense_Mutation_p.K1678N|MYLK_ENST00000346322.5_Missense_Mutation_p.K1660N|MYLK-AS1_ENST00000470449.1_RNA|MYLK-AS1_ENST00000463408.1_RNA|MYLK-AS1_ENST00000485162.1_RNA|MYLK_ENST00000354792.5_Missense_Mutation_p.K529N			Q15746	MYLK_HUMAN	myosin light chain kinase	1729	Protein kinase.				aorta smooth muscle tissue morphogenesis|muscle contraction	cytosol	actin binding|ATP binding|calmodulin binding|metal ion binding|myosin light chain kinase activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(24)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(17)|lung(37)|ovary(7)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	113		Lung NSC(201;0.0496)		GBM - Glioblastoma multiforme(114;0.0736)		TGGAGAGTTTCTTGGCCTCCA	0.488000													19	32					4.59853e-10	5.36495e-10	0.693898	1	0
WBP4	11193	broad.mit.edu	37	13	41636806	41636806	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr13:41636806A>G	ENST00000379487.3	+	2	429	c.29A>G	c.(28-30)aAg>aGg	p.K10R	WBP4_ENST00000542082.1_Missense_Mutation_p.K10R	NM_007187.3	NP_009118.1	O75554	WBP4_HUMAN	WW domain binding protein 4	10					nuclear mRNA cis splicing, via spliceosome	nuclear speck|spliceosomal complex	nucleic acid binding|proline-rich region binding|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|liver(2)|lung(2)|prostate(1)|skin(1)	12		Lung NSC(96;3.55e-06)|Breast(139;0.00123)|Prostate(109;0.0181)|Lung SC(185;0.0262)|Hepatocellular(98;0.114)		all cancers(112;3.11e-09)|Epithelial(112;3.37e-06)|OV - Ovarian serous cystadenocarcinoma(117;8.3e-05)|GBM - Glioblastoma multiforme(144;0.00102)|BRCA - Breast invasive adenocarcinoma(63;0.07)		TCACAGCCAAAGAAATTCTGT	0.378000													6	10					0	0	0.217242	0	0
EIF4E	1977	broad.mit.edu	37	4	99809080	99809080	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr4:99809080G>C	ENST00000450253.2	-	4	1769	c.245C>G	c.(244-246)tCt>tGt	p.S82C	EIF4E_ENST00000505992.1_Missense_Mutation_p.S82C|EIF4E_ENST00000280892.6_Missense_Mutation_p.S102C|EIF4E_ENST00000504432.1_Missense_Mutation_p.S110C	NM_001968.3	NP_001959.1	P06730	IF4E_HUMAN	eukaryotic translation initiation factor 4E	82					G1/S transition of mitotic cell cycle|insulin receptor signaling pathway|interspecies interaction between organisms|mRNA export from nucleus|nuclear-transcribed mRNA poly(A) tail shortening|positive regulation of mitotic cell cycle|regulation of translation	cytoplasmic mRNA processing body|cytosol|eukaryotic translation initiation factor 4F complex|mRNA cap binding complex|RNA-induced silencing complex	protein binding|RNA cap binding|translation initiation factor activity			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(6)|prostate(1)|skin(1)	13				OV - Ovarian serous cystadenocarcinoma(123;2.7e-07)|LUSC - Lung squamous cell carcinoma(721;0.00227)		TAAATTACTAGACAACTGGAT	0.289000													3	19					0	0	0.184627	0	0
NALCN	259232	broad.mit.edu	37	13	101890210	101890210	+	Nonsense_Mutation	SNP	C	C	A			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr13:101890210C>A	ENST00000251127.6	-	12	1411	c.1330G>T	c.(1330-1332)Gga>Tga	p.G444*	NALCN_ENST00000470333.1_5'UTR|NALCN_ENST00000376196.3_Nonsense_Mutation_p.G444*	NM_052867.2	NP_443099.1	Q8IZF0	NALCN_HUMAN	sodium leak channel, non-selective	444						integral to membrane	sodium channel activity|voltage-gated ion channel activity			NS(1)|autonomic_ganglia(2)|breast(6)|central_nervous_system(2)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(33)|liver(2)|lung(81)|ovary(8)|pancreas(3)|prostate(5)|skin(6)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	177	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					CTAATATATCCAGTAAATCCC	0.343000													41	59					1.43246e-33	1.86135e-33	0.834066	1	0
OR14I1	401994	broad.mit.edu	37	1	248845530	248845530	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr1:248845530C>A	ENST00000342623.3	-	1	99	c.76G>T	c.(76-78)Gcc>Tcc	p.A26S		NM_001004734.1	NP_001004734.1	A6ND48	O14I1_HUMAN	olfactory receptor, family 14, subfamily I, member 1	26					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(4)|large_intestine(2)|lung(24)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)	35						AACAGCCCGGCGTGCAGCACC	0.493000													47	67					3.68337e-26	4.64705e-26	0.870114	1	0
DMPK	1760	broad.mit.edu	37	19	46283080	46283080	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr19:46283080C>T	ENST00000600757.1	-	1	925	c.238G>A	c.(238-240)Gac>Aac	p.D80N	DMPK_ENST00000343373.4_Missense_Mutation_p.D80N|AC011530.4_ENST00000593999.1_3'UTR|DMPK_ENST00000447742.2_Missense_Mutation_p.D70N|DMPK_ENST00000458663.2_Missense_Mutation_p.D70N|DMPK_ENST00000354227.5_Missense_Mutation_p.D70N|DMPK_ENST00000291270.4_Missense_Mutation_p.D70N			Q09013	DMPK_HUMAN	dystrophia myotonica-protein kinase	80					regulation of heart contraction		ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			endometrium(5)|kidney(1)|large_intestine(1)|lung(6)|stomach(1)|urinary_tract(2)	16		Ovarian(192;0.0308)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.00616)|GBM - Glioblastoma multiforme(486;0.0825)|Epithelial(262;0.24)		ATCTCGAAGTCGTCCCTCTGC	0.642000													3	26					0	0	0.115264	0	0
ARID2	196528	broad.mit.edu	37	12	46254641	46254641	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr12:46254641C>G	ENST00000334344.6	+	16	5003	c.4831C>G	c.(4831-4833)Cag>Gag	p.Q1611E	ARID2_ENST00000479608.1_3'UTR|ARID2_ENST00000444670.1_Missense_Mutation_p.Q1221E|ARID2_ENST00000457135.1_Missense_Mutation_p.Q219E|ARID2_ENST00000422737.1_Missense_Mutation_p.Q1462E	NM_152641.2	NP_689854.2	Q68CP9	ARID2_HUMAN	AT rich interactive domain 2 (ARID, RFX-like)	1611					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(7)|central_nervous_system(3)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(21)|liver(20)|lung(34)|ovary(7)|pancreas(1)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	116	Lung SC(27;0.192)|Renal(347;0.236)	Lung NSC(34;0.106)|all_lung(34;0.22)	OV - Ovarian serous cystadenocarcinoma(5;0.00691)	GBM - Glioblastoma multiforme(48;0.0153)		TAACAGTTCTCAGCCTTCTCC	0.463000			"""N, S, F"""		hepatocellular carcinoma								20	27					0	0	0.592651	0	0
ETS1	2113	broad.mit.edu	37	11	128350260	128350260	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr11:128350260A>T	ENST00000392668.3	-	8	1017	c.949T>A	c.(949-951)Tct>Act	p.S317T	ETS1_ENST00000531611.1_Intron|ETS1_ENST00000535549.1_Missense_Mutation_p.S57T|ETS1_ENST00000526145.1_Intron|ETS1_ENST00000345075.4_Intron|ETS1_ENST00000319397.5_Missense_Mutation_p.S273T	NM_001143820.1	NP_001137292.1	P14921	ETS1_HUMAN	v-ets avian erythroblastosis virus E26 oncogene homolog 1	273					cell motility|immune response|induction of apoptosis|negative regulation of cell cycle|negative regulation of cell proliferation|PML body organization|positive regulation of cellular component movement|positive regulation of erythrocyte differentiation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|response to antibiotic|transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(5)|kidney(1)|large_intestine(3)|lung(15)|ovary(1)|pleura(1)|prostate(1)|upper_aerodigestive_tract(3)	35	all_hematologic(175;0.0537)	Lung NSC(97;0.000542)|all_lung(97;0.000665)|Breast(109;0.00765)|all_neural(223;0.0351)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;1.47e-05)|OV - Ovarian serous cystadenocarcinoma(99;0.0174)|LUSC - Lung squamous cell carcinoma(976;0.0815)|Lung(307;0.0833)		CTGTTGAAAGATGACTGGCTG	0.552000													22	44					0	0	0.639603	0	0
CPSF6	11052	broad.mit.edu	37	12	69652822	69652822	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr12:69652822C>G	ENST00000435070.2	+	6	1257	c.1147C>G	c.(1147-1149)Cca>Gca	p.P383A	CPSF6_ENST00000266679.8_Missense_Mutation_p.P420A|CPSF6_ENST00000456847.3_Missense_Mutation_p.P310A|CPSF6_ENST00000551516.1_Intron	NM_007007.2	NP_008938.2	Q16630	CPSF6_HUMAN	cleavage and polyadenylation specific factor 6, 68kDa	383	Pro-rich.				mRNA polyadenylation|protein tetramerization	mRNA cleavage factor complex|paraspeckles|ribonucleoprotein complex	mRNA binding|nucleotide binding|protein binding			endometrium(1)|large_intestine(7)|lung(8)	16	all_epithelial(5;2.47e-36)|Lung NSC(4;1.1e-32)|all_lung(4;6.26e-31)|Breast(13;1.59e-06)|Esophageal squamous(21;0.187)		Epithelial(6;4.89e-17)|BRCA - Breast invasive adenocarcinoma(5;8.5e-10)|Lung(24;6.04e-05)|LUAD - Lung adenocarcinoma(15;0.00107)|STAD - Stomach adenocarcinoma(21;0.0151)|LUSC - Lung squamous cell carcinoma(43;0.171)|Kidney(9;0.241)			ACCAACAGATCCATATGGGCG	0.507000													41	68					0	0	0.853193	0	0
FRMD1	79981	broad.mit.edu	37	6	168461497	168461497	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr6:168461497G>T	ENST00000283309.6	-	9	1350	c.1286C>A	c.(1285-1287)cCg>cAg	p.P429Q	FRMD1_ENST00000440994.2_Missense_Mutation_p.P361Q|FRMD1_ENST00000537786.1_Missense_Mutation_p.P200Q|FRMD1_ENST00000432403.1_5'UTR	NM_024919.3	NP_079195.3	Q8N878	FRMD1_HUMAN	FERM domain containing 1	429						cytoskeleton	binding			endometrium(3)|kidney(2)|large_intestine(5)|lung(6)|ovary(1)|prostate(1)|urinary_tract(1)	19		Breast(66;1.07e-05)|Ovarian(120;0.0728)		Epithelial(4;7.7e-30)|OV - Ovarian serous cystadenocarcinoma(33;5.82e-22)|BRCA - Breast invasive adenocarcinoma(4;1.38e-10)|GBM - Glioblastoma multiforme(31;0.000756)		GCTGGAGGACGGCTCCTTCTC	0.642000													3	5					0.00909568	0.00953508	0.150653	1	0
CCDC39	339829	broad.mit.edu	37	3	180378511	180378511	+	Silent	SNP	G	G	T			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr3:180378511G>T	ENST00000273654.4	-	10	1234	c.615C>A	c.(613-615)ggC>ggA	p.G205G	CCDC39_ENST00000442201.2_Silent_p.G121G			Q9UFE4	CCD39_HUMAN	coiled-coil domain containing 39	121					axonemal dynein complex assembly|ciliary cell motility|cilium movement involved in determination of left/right asymmetry|flagellar cell motility	cilium axoneme|cytoplasm|cytoskeleton				NS(1)|breast(1)|endometrium(4)|large_intestine(9)|lung(22)|ovary(6)|prostate(2)	45	all_cancers(143;9.31e-15)|Ovarian(172;0.0212)		OV - Ovarian serous cystadenocarcinoma(80;5.62e-23)|GBM - Glioblastoma multiforme(14;0.000558)			CTTTAAATATGCCATTCTAAT	0.343000													3	39					0.150653	0.153483	0.150653	1	0
C12orf57	113246	broad.mit.edu	37	12	7053849	7053849	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr12:7053849G>A	ENST00000544681.1	+	2	568	c.263G>A	c.(262-264)gGg>gAg	p.G88E	C12orf57_ENST00000229281.5_Intron|C12orf57_ENST00000537087.1_Intron|C12orf57_ENST00000542222.1_Intron|C12orf57_ENST00000540506.2_Intron			Q99622	C10_HUMAN	chromosome 12 open reading frame 57	88										kidney(1)|large_intestine(1)	2						GTCAGACGCGGGAAGGCGGGA	0.647000											OREG0021642	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	3	17					0	0	0.115264	0	0
SOX5	6660	broad.mit.edu	37	12	23728667	23728667	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr12:23728667T>A	ENST00000546136.1	-	9	1233	c.1231A>T	c.(1231-1233)Agt>Tgt	p.S411C	SOX5_ENST00000451604.2_Missense_Mutation_p.S424C|SOX5_ENST00000309359.1_Missense_Mutation_p.S411C|SOX5_ENST00000541536.1_Intron|SOX5_ENST00000537393.1_Missense_Mutation_p.S389C|SOX5_ENST00000545921.1_Missense_Mutation_p.S414C|SOX5_ENST00000381381.2_Intron|SOX5_ENST00000396007.2_Missense_Mutation_p.S38C			P35711	SOX5_HUMAN	SRY (sex determining region Y)-box 5	424					transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(25)|ovary(5)|skin(2)|upper_aerodigestive_tract(3)	57						CCTGCCCCACTGTTTATTCTC	0.512000													4	81					0	0	0.150653	0	0
GNMT	27232	broad.mit.edu	37	6	42930898	42930898	+	Silent	SNP	C	C	T	rs147746130		TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr6:42930898C>T	ENST00000372808.3	+	4	550	c.540C>T	c.(538-540)taC>taT	p.Y180Y		NM_018960.4	NP_061833.1	Q14749	GNMT_HUMAN	glycine N-methyltransferase	180					protein homotetramerization|protein modification process|S-adenosylmethionine metabolic process		folic acid binding|glycine binding|glycine N-methyltransferase activity			kidney(2)|large_intestine(1)|lung(1)	4	Colorectal(47;0.196)		all cancers(41;0.00196)|Colorectal(64;0.00237)|COAD - Colon adenocarcinoma(64;0.00473)|KIRC - Kidney renal clear cell carcinoma(15;0.02)|Kidney(15;0.0388)|OV - Ovarian serous cystadenocarcinoma(102;0.0461)		Glycine(DB00145)|S-Adenosylmethionine(DB00118)	ATCGCAACTACGACCACATCC	0.627000													4	42					0	0	0.217242	0	0
ZNF254	9534	broad.mit.edu	37	19	24309364	24309364	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr19:24309364G>T	ENST00000357002.4	+	4	677	c.562G>T	c.(562-564)Gtc>Ttc	p.V188F	ZNF254_ENST00000342944.6_Missense_Mutation_p.V103F	NM_001278661.1|NM_001278662.1|NM_001278664.1|NM_001278677.1|NM_001278678.1|NM_203282.2	NP_001265590.1|NP_001265591.1|NP_001265593.1|NP_001265606.1|NP_001265607.1|NP_975011.3	O75437	ZN254_HUMAN	zinc finger protein 254	188					negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding						all_cancers(12;0.086)|all_lung(12;0.00528)|Lung NSC(12;0.00731)|all_epithelial(12;0.0186)				TAAAAAACGTGTCAAATTATT	0.269000													19	59					1.10513e-12	1.3323e-12	0.624587	1	0
SHOX	6473	broad.mit.edu	37	X	591647	591647	+	Silent	SNP	G	G	C			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chrX:591647G>C	ENST00000381578.1	+	2	706	c.15G>C	c.(13-15)acG>acC	p.T5T	SHOX_ENST00000334060.3_Silent_p.T5T|SHOX_ENST00000554971.1_Silent_p.T5T|SHOX_ENST00000381575.1_Silent_p.T5T	NM_000451.3	NP_000442.1	O15266	SHOX_HUMAN	short stature homeobox	5					skeletal system development|transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(3)|lung(9)|prostate(1)	13		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				AAGAGCTCACGGCTTTTGTAT	0.652000													5	6					0	0	0.248553	0	0
TGFBR3	7049	broad.mit.edu	37	1	92184900	92184900	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr1:92184900G>A	ENST00000212355.4	-	10	2000	c.1535C>T	c.(1534-1536)tCa>tTa	p.S512L	TGFBR3_ENST00000525962.1_Missense_Mutation_p.S512L|TGFBR3_ENST00000370399.2_Missense_Mutation_p.S511L	NM_001195683.1|NM_003243.4	NP_001182612.1|NP_003234.2	Q03167	TGBR3_HUMAN	transforming growth factor, beta receptor III	512	ZP.				BMP signaling pathway|cardiac epithelial to mesenchymal transition|cardiac muscle cell proliferation|cell growth|cell migration|definitive erythrocyte differentiation|heart trabecula formation|immune response|intracellular protein kinase cascade|liver development|negative regulation of cellular component movement|negative regulation of epithelial cell proliferation|palate development|pathway-restricted SMAD protein phosphorylation|response to follicle-stimulating hormone stimulus|response to luteinizing hormone stimulus|response to prostaglandin E stimulus|transforming growth factor beta receptor signaling pathway|ventricular cardiac muscle tissue morphogenesis	external side of plasma membrane|extracellular space|inhibin-betaglycan-ActRII complex|integral to plasma membrane|intracellular membrane-bounded organelle	coreceptor activity|heparin binding|PDZ domain binding|SMAD binding|transforming growth factor beta binding|transforming growth factor beta receptor activity, type III|type II transforming growth factor beta receptor binding			endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(24)|ovary(3)|prostate(4)|skin(1)|stomach(1)|urinary_tract(3)	55		all_lung(203;0.00719)|Lung NSC(277;0.0268)		all cancers(265;0.0108)|Epithelial(280;0.0825)		ATCAAGGGCTGACCACCGGGG	0.527000													54	47					0	0	0.870114	0	0
LOC286238	286238	broad.mit.edu	37	9	91262362	91262362	+	RNA	SNP	G	G	A			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr9:91262362G>A	ENST00000418343.2	-	0	389																											ATGACACGCTGGCCAGCCACA	0.438000													29	18					0	0	0.717897	0	0
KIF4B	285643	broad.mit.edu	37	5	154393718	154393718	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr5:154393718G>A	ENST00000435029.4	+	1	459	c.299G>A	c.(298-300)gGt>gAt	p.G100D		NM_001099293.1	NP_001092763.1	Q2VIQ3	KIF4B_HUMAN	kinesin family member 4B	100	Kinesin-motor.				axon guidance|blood coagulation|microtubule-based movement	cytosol|microtubule|nuclear matrix	ATP binding|DNA binding|microtubule motor activity			breast(1)|central_nervous_system(1)|endometrium(7)|kidney(6)|large_intestine(13)|lung(27)|ovary(2)|upper_aerodigestive_tract(1)	58	Renal(175;0.00488)	Medulloblastoma(196;0.0523)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)			TCAATGGGAGGTGCATACACT	0.428000													14	103					0	0	0.520397	0	0
MAGEE2	139599	broad.mit.edu	37	X	75003939	75003939	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chrX:75003939A>T	ENST00000373359.2	-	1	1140	c.948T>A	c.(946-948)aaT>aaA	p.N316K		NM_138703.4	NP_619648.1	Q8TD90	MAGE2_HUMAN	melanoma antigen family E, 2	316	MAGE 2.									autonomic_ganglia(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(17)|ovary(1)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	34						GGACCAAATCATTTGCCTTAT	0.443000													14	11					0	0	0.479597	0	0
MYH2	4620	broad.mit.edu	37	17	10450895	10450895	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr17:10450895G>T	ENST00000245503.5	-	4	629	c.245C>A	c.(244-246)cCt>cAt	p.P82H	MYH2_ENST00000397183.2_Missense_Mutation_p.P82H|MYH2_ENST00000532183.1_Missense_Mutation_p.P82H|CTC-297N7.7_ENST00000587182.1_RNA	NM_017534.5	NP_060004.3	Q9UKX2	MYH2_HUMAN	myosin, heavy chain 2, skeletal muscle, adult	82	Myosin head-like.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(16)|lung(99)|ovary(6)|pancreas(4)|prostate(3)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(4)	176						ATATTTGGGAGGGTTCATGGG	0.438000													45	183					5.18031e-10	6.01138e-10	0.870114	1	0
UGT2A2	574537	broad.mit.edu	37	4	70504819	70504819	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr4:70504819C>A	ENST00000457664.2	-	1	539	c.540G>T	c.(538-540)ttG>ttT	p.L180F	UGT2A1_ENST00000514019.1_Missense_Mutation_p.L381F|UGT2A1_ENST00000512704.1_Intron|UGT2A1_ENST00000286604.4_Intron|UGT2A1_ENST00000503640.1_Intron	NM_001105677.2	NP_001099147.2																					GAGAGAACCTCAATGTGTACA	0.458000													36	42					1.836e-18	2.25092e-18	0.788014	1	0
ZNF623	9831	broad.mit.edu	37	8	144733483	144733483	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr8:144733483C>T	ENST00000501748.2	+	1	1530	c.1441C>T	c.(1441-1443)Cat>Tat	p.H481Y	ZNF623_ENST00000458270.2_Missense_Mutation_p.H441Y|ZNF623_ENST00000526926.1_Missense_Mutation_p.H441Y	NM_014789.3	NP_055604.3	O75123	ZN623_HUMAN	zinc finger protein 623	481					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(2)|kidney(3)|large_intestine(6)|lung(11)|prostate(1)|stomach(1)|urinary_tract(3)	27	all_cancers(97;3.74e-11)|all_epithelial(106;2.62e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;5.28e-40)|all cancers(56;5.23e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.146)			CCAGAAAATTCATACTGAAGA	0.393000													132	142					0	0	0.870114	0	0
CNOT6L	246175	broad.mit.edu	37	4	78652605	78652605	+	Silent	SNP	C	C	A			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr4:78652605C>A	ENST00000504123.1	-	9	1090	c.960G>T	c.(958-960)gtG>gtT	p.V320V	CNOT6L_ENST00000264903.4_Silent_p.V320V			Q96LI5	CNO6L_HUMAN	CCR4-NOT transcription complex, subunit 6-like	320					nuclear-transcribed mRNA poly(A) tail shortening	cytosol	exonuclease activity|protein binding			kidney(1)|large_intestine(1)|lung(6)|urinary_tract(1)	9						CTTTTGTCATCACTCTGTTCA	0.378000													9	45					4.68919e-08	5.32751e-08	0.361761	1	0
TPTE2P6	374491	broad.mit.edu	37	13	25161397	25161397	+	RNA	SNP	C	C	G	rs3874227	by1000genomes	TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr13:25161397C>G	ENST00000453498.1	+	0	921																											TGAAACATCTCTACAACTGGA	0.343000													4	79					0	0	0.184627	0	0
FRMPD4	9758	broad.mit.edu	37	X	12736345	12736345	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chrX:12736345C>T	ENST00000380682.1	+	16	3906	c.3400C>T	c.(3400-3402)Cct>Tct	p.P1134S		NM_014728.3	NP_055543.2	Q14CM0	FRPD4_HUMAN	FERM and PDZ domain containing 4	1134					positive regulation of synapse structural plasticity	cytoskeleton|dendritic spine	phosphatidylinositol-4,5-bisphosphate binding|protein binding			breast(1)|central_nervous_system(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(1)|ovary(3)|pancreas(1)|skin(3)	22						AGAAGGAGCTCCTGATGGAGA	0.507000													71	54					0	0	0.870114	0	0
GPRC6A	222545	broad.mit.edu	37	6	117121855	117121855	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr6:117121855C>A	ENST00000310357.3	-	4	1461	c.1440G>T	c.(1438-1440)aaG>aaT	p.K480N	GPRC6A_ENST00000368549.3_Intron|GPRC6A_ENST00000530250.1_Missense_Mutation_p.K305N	NM_148963.2	NP_683766.2	Q5T6X5	GPC6A_HUMAN	G protein-coupled receptor, family C, group 6, member A	480					response to amino acid stimulus		G-protein coupled receptor activity			autonomic_ganglia(1)|breast(4)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(8)|liver(1)|lung(24)|ovary(5)|pancreas(1)|skin(5)|stomach(3)|upper_aerodigestive_tract(3)	65		all_cancers(87;0.0314)|all_epithelial(87;0.0216)|Colorectal(196;0.234)		GBM - Glioblastoma multiforme(226;0.0265)|all cancers(137;0.0554)|OV - Ovarian serous cystadenocarcinoma(136;0.07)		CATTGATCTCCTTCCAGAGCA	0.388000													54	57					1.38705e-31	1.77053e-31	0.870114	1	0
MT-CO3	4514	broad.mit.edu	37	MT	9882	9882	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chrM:9882C>T	ENST00000362079.2	+	1	676	c.676C>T	c.(676-678)Cac>Tac	p.226_226insY						mitochondrially encoded cytochrome c oxidase III											breast(1)|endometrium(10)|kidney(14)|lung(1)|urinary_tract(1)	27						AACTAATATTTCACTTTACAT	0.428000													6	412					0	0	0.217242	0	0
FAM178A	55719	broad.mit.edu	37	10	102706855	102706855	+	Nonsense_Mutation	SNP	G	G	A			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr10:102706855G>A	ENST00000238961.3	+	14	3142	c.2994G>A	c.(2992-2994)tgG>tgA	p.W998*	FAM178A_ENST00000370269.3_Nonsense_Mutation_p.W998*	NM_018121.3	NP_060591.3	Q8IX21	F178A_HUMAN	family with sequence similarity 178, member A	998																	ACCTCCTGTGGTTGGTACAGC	0.358000													21	75					0	0	0.667858	0	0
PARP16	54956	broad.mit.edu	37	15	65553241	65553241	+	Nonsense_Mutation	SNP	G	G	C			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr15:65553241G>C	ENST00000261888.6	-	5	1260	c.815C>G	c.(814-816)tCa>tGa	p.S272*	PARP16_ENST00000444347.2_Nonsense_Mutation_p.S157*	NM_017851.4	NP_060321.3	Q8N5Y8	PAR16_HUMAN	poly (ADP-ribose) polymerase family, member 16	272	PARP catalytic.					integral to membrane	NAD+ ADP-ribosyltransferase activity			kidney(1)|large_intestine(1)|lung(5)|prostate(1)|skin(1)	9						TGGCTTCTGTGAATACACCAG	0.507000													4	133					0	0	0.150653	0	0
WDR3	10885	broad.mit.edu	37	1	118492649	118492649	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr1:118492649C>A	ENST00000349139.4	+	15	1689	c.1642C>A	c.(1642-1644)Cta>Ata	p.L548I		NM_006784.2	NP_006775.1	Q9UNX4	WDR3_HUMAN	WD repeat domain 3	548						nuclear membrane|nucleolus				breast(2)|cervix(2)|endometrium(5)|kidney(4)|large_intestine(9)|liver(2)|lung(22)|prostate(2)|upper_aerodigestive_tract(1)	49	Esophageal squamous(2;0.162)	all_cancers(81;2.72e-05)|Acute lymphoblastic leukemia(138;1e-08)|all_epithelial(167;4.4e-07)|all_lung(203;1.7e-06)|Lung NSC(69;1.98e-05)|Prostate(1639;0.00955)|Breast(1374;0.244)		OV - Ovarian serous cystadenocarcinoma(397;1.39e-08)|Epithelial(280;1.82e-07)|all cancers(265;2.04e-05)|Lung(183;0.0525)|BRCA - Breast invasive adenocarcinoma(282;0.0695)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.185)		AACTTTGCAACTAGATGAAGA	0.358000													17	209					2.00529e-23	2.50085e-23	0.654019	1	0
RNF17	56163	broad.mit.edu	37	13	25442836	25442836	+	Silent	SNP	C	C	T			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr13:25442836C>T	ENST00000255324.5	+	31	4312	c.4260C>T	c.(4258-4260)caC>caT	p.H1420H	RNF17_ENST00000339524.3_Silent_p.H430H|RNF17_ENST00000381921.1_Silent_p.H1378H	NM_001184993.1|NM_031277.2	NP_001171922.1|NP_112567.2	Q9BXT8	RNF17_HUMAN	ring finger protein 17	1420					multicellular organismal development	cytoplasm|nucleus	hydrolase activity, acting on ester bonds|nucleic acid binding|zinc ion binding			NS(1)|breast(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(15)|ovary(1)|prostate(3)|skin(6)	36		Lung SC(185;0.0225)|Breast(139;0.077)		all cancers(112;0.0114)|OV - Ovarian serous cystadenocarcinoma(117;0.0311)|Epithelial(112;0.0524)		AAGTTAAGCACGTTGTCTCAC	0.388000													4	95					0	0	0.184627	0	0
NR2C2	7182	broad.mit.edu	37	3	15057759	15057759	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr3:15057759C>T	ENST00000425241.1	+	4	736	c.374C>T	c.(373-375)tCc>tTc	p.S125F	NR2C2_ENST00000393102.3_Missense_Mutation_p.S125F|NR2C2_ENST00000323373.6_Missense_Mutation_p.S144F|NR2C2_ENST00000406272.2_Missense_Mutation_p.S125F			P49116	NR2C2_HUMAN	nuclear receptor subfamily 2, group C, member 2	125					cell differentiation|nervous system development|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|spermatogenesis	nucleoplasm	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|transcription coactivator activity|zinc ion binding			breast(1)|endometrium(2)|large_intestine(5)|lung(5)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	16						GACAAAGCCTCCGGTATGTAG	0.507000													12	28					0	0	0.479597	0	0
NDST2	8509	broad.mit.edu	37	10	75565704	75565704	+	Missense_Mutation	SNP	C	C	T	rs150846687	byFrequency	TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr10:75565704C>T	ENST00000299641.4	-	8	2118	c.1148G>A	c.(1147-1149)cGg>cAg	p.R383Q	NDST2_ENST00000309979.6_Missense_Mutation_p.R506Q	NM_003635.3	NP_003626.1	P52849	NDST2_HUMAN	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2	506	Heparan sulfate N-deacetylase 2.					Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine N-sulfotransferase activity|hydrolase activity			cervix(1)|endometrium(4)|kidney(1)|large_intestine(7)|lung(11)|ovary(2)|prostate(2)|skin(1)|urinary_tract(1)	30	Prostate(51;0.0112)					TCGGATGCTCCGGTCTAGTTC	0.522000													13	67					0	0	0.457914	0	0
TRANK1	9881	broad.mit.edu	37	3	36899467	36899467	+	Silent	SNP	G	G	C			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr3:36899467G>C	ENST00000429976.2	-	12	1861	c.1614C>G	c.(1612-1614)ctC>ctG	p.L538L	TRANK1_ENST00000301807.6_5'UTR|TRANK1_ENST00000428977.2_5'UTR			O15050	TRNK1_HUMAN	tetratricopeptide repeat and ankyrin repeat containing 1	538					DNA repair		ATP binding|ATP-dependent DNA helicase activity|DNA binding			NS(2)|autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|lung(20)|ovary(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	73						CATTGGGGTTGAGGTAGTCGA	0.493000													16	64					0	0	0.500413	0	0
CHD5	26038	broad.mit.edu	37	1	6196606	6196606	+	Silent	SNP	G	G	T			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr1:6196606G>T	ENST00000262450.3	-	17	2766	c.2667C>A	c.(2665-2667)ctC>ctA	p.L889L	CHD5_ENST00000378021.1_5'UTR	NM_015557.2	NP_056372.1	Q8TDI0	CHD5_HUMAN	chromodomain helicase DNA binding protein 5	889	Helicase ATP-binding.				chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|DNA binding|zinc ion binding			breast(3)|central_nervous_system(3)|liver(1)|lung(1)|ovary(4)|pancreas(1)|skin(1)|upper_aerodigestive_tract(2)	16	Ovarian(185;0.0634)	all_cancers(23;5.36e-32)|all_epithelial(116;2.32e-17)|all_neural(13;3.68e-06)|all_lung(118;3.94e-06)|all_hematologic(16;2.39e-05)|Lung NSC(185;5.33e-05)|Acute lymphoblastic leukemia(12;0.000372)|Glioma(11;0.00127)|Renal(390;0.00188)|Colorectal(325;0.00342)|Breast(487;0.00373)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.15)		Epithelial(90;3.08e-37)|GBM - Glioblastoma multiforme(13;1.36e-31)|OV - Ovarian serous cystadenocarcinoma(86;7.7e-19)|Colorectal(212;9.97e-08)|COAD - Colon adenocarcinoma(227;1.07e-05)|Kidney(185;6.16e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.00109)|BRCA - Breast invasive adenocarcinoma(365;0.0012)|STAD - Stomach adenocarcinoma(132;0.00346)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.193)		GGAAGTTGAGGAGATGGAACA	0.537000													4	36					1.23904e-05	1.37179e-05	0.184627	1	0
TTC30B	150737	broad.mit.edu	37	2	178415811	178415811	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr2:178415811C>T	ENST00000408939.2	-	1	1931	c.1681G>A	c.(1681-1683)Gac>Aac	p.D561N		NM_152517.2	NP_689730.2	Q8N4P2	TT30B_HUMAN	tetratricopeptide repeat domain 30B	561					cell projection organization	cilium	binding			cervix(1)|endometrium(1)|kidney(4)|large_intestine(7)|lung(6)|prostate(1)|skin(2)|urinary_tract(1)	23			OV - Ovarian serous cystadenocarcinoma(117;0.00151)|Epithelial(96;0.00931)|all cancers(119;0.0362)			ATACCAAAGTCATAATTTCCT	0.393000													6	191					0	0	0.217242	0	0
SZT2	23334	broad.mit.edu	37	1	43904467	43904467	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr1:43904467G>T	ENST00000562955.1	+	46	6435	c.6435G>T	c.(6433-6435)aaG>aaT	p.K2145N	SZT2_ENST00000372442.1_Missense_Mutation_p.K1303N|SZT2_ENST00000471177.1_3'UTR	NM_015284.3	NP_056099.3	Q5T011	SZT2_HUMAN	seizure threshold 2 homolog (mouse)	2202						peroxisome				NS(2)|breast(9)|central_nervous_system(1)|endometrium(17)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(19)|lung(39)|ovary(4)|pancreas(3)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	113						GGAACTGCAAGCTGACACCAG	0.567000													5	110					0.0215528	0.0223777	0.217242	1	0
NAV3	89795	broad.mit.edu	37	12	78598805	78598805	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr12:78598805C>T	ENST00000397909.2	+	39	7098	c.6925C>T	c.(6925-6927)Cca>Tca	p.P2309S	NAV3_ENST00000541270.1_Missense_Mutation_p.P139S|NAV3_ENST00000536525.2_Missense_Mutation_p.P2287S|NAV3_ENST00000228327.6_Missense_Mutation_p.P2287S|NAV3_ENST00000266692.7_Missense_Mutation_p.P2110S			Q8IVL0	NAV3_HUMAN	neuron navigator 3	2309						nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			NS(2)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(13)|kidney(16)|large_intestine(39)|liver(2)|lung(126)|ovary(5)|pancreas(3)|prostate(6)|skin(5)|stomach(2)|upper_aerodigestive_tract(8)|urinary_tract(1)	236						TCAGGAGAGCCCAGCCTTACT	0.493000										HNSCC(70;0.22)			21	34					0	0	0.575678	0	0
LINC01410	103352539	broad.mit.edu	37	9	66457330	66457330	+	RNA	SNP	G	G	T			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr9:66457330G>T	ENST00000424345.1	+	0	42																											cagcgacagagccttggagag	0.632000													5	9					0.0293803	0.0303597	0.248553	1	0
RP11-423O2.5	0	broad.mit.edu	37	1	142803746	142803746	+	RNA	SNP	A	A	G			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr1:142803746A>G	ENST00000423385.1	-	0	1219																											actatggattagagctgatta	0.393000													2	0					0	0	0.115264	0	0
DCX	1641	broad.mit.edu	37	X	110644336	110644336	+	Missense_Mutation	SNP	C	C	T	rs56030372		TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chrX:110644336C>T	ENST00000338081.3	-	3	1001	c.830G>A	c.(829-831)cGt>cAt	p.R277H	DCX_ENST00000356915.2_Missense_Mutation_p.R196H|DCX_ENST00000496551.1_5'UTR|DCX_ENST00000356220.3_Missense_Mutation_p.R196H|DCX_ENST00000371993.2_Missense_Mutation_p.R196H|DCX_ENST00000488120.1_Missense_Mutation_p.R196H	NM_000555.3	NP_000546.2	O43602	DCX_HUMAN	doublecortin	277	Doublecortin 2.		R -> H (in LISX1; dbSNP:rs56030372).|R -> S (in epilepsy; resistant partial seizures; related to 'cryptogenic' epilepsy).		axon guidance|central nervous system development|intracellular signal transduction	cytosol|microtubule associated complex	microtubule binding			breast(1)|central_nervous_system(2)|endometrium(3)|kidney(1)|large_intestine(10)|lung(17)|skin(6)|upper_aerodigestive_tract(1)	41						CAGAAGCACACGCACAGCCTT	0.532000													18	18					0	0	0.539581	0	0
ATP6V0E1	8992	broad.mit.edu	37	5	172447277	172447277	+	Silent	SNP	C	C	G			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr5:172447277C>G	ENST00000519374.1	+	3	293	c.189C>G	c.(187-189)ctC>ctG	p.L63L	ATP6V0E1_ENST00000519911.1_Intron|ATP6V0E1_ENST00000265093.4_Silent_p.L47L|ATP6V0E1_ENST00000517669.1_Silent_p.L63L	NM_003945.3	NP_003936.1	O15342	VA0E1_HUMAN	ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1	63					ATP hydrolysis coupled proton transport|cell growth|cellular iron ion homeostasis|insulin receptor signaling pathway|transferrin transport|vacuolar acidification	endosome membrane|integral to membrane|membrane fraction|proton-transporting V-type ATPase, V0 domain|vacuole	proton-transporting ATPase activity, rotational mechanism			lung(2)	2	Renal(175;0.000159)|Lung NSC(126;0.00223)|all_lung(126;0.00391)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			TCAACCCTCTCTTTGGACCGC	0.433000													45	31					0	0	0.870114	0	0
SMARCA4	6597	broad.mit.edu	37	19	11169030	11169030	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr19:11169030G>C	ENST00000358026.2	+	32	4904	c.4620G>C	c.(4618-4620)aaG>aaC	p.K1540N	SMARCA4_ENST00000344626.4_Missense_Mutation_p.K1508N|SMARCA4_ENST00000429416.3_Missense_Mutation_p.K1508N|SMARCA4_ENST00000541122.2_Missense_Mutation_p.K1478N|SMARCA4_ENST00000444061.3_Missense_Mutation_p.K1474N|SMARCA4_ENST00000413806.3_Missense_Mutation_p.K1478N|SMARCA4_ENST00000590574.1_Missense_Mutation_p.K1475N|SMARCA4_ENST00000589677.1_Missense_Mutation_p.K1477N|SMARCA4_ENST00000450717.3_Missense_Mutation_p.K1477N	NM_001128849.1	NP_001122321.1	P51532	SMCA4_HUMAN	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	1508	Bromo.	Required for binding to 'Lys-15'- acetylated histone 3.			chromatin remodeling|negative regulation of androgen receptor signaling pathway|negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|negative regulation of transcription from RNA polymerase II promoter|nervous system development|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nBAF complex|npBAF complex|nuclear chromatin|SWI/SNF complex|WINAC complex	androgen receptor binding|ATP binding|DNA binding|DNA-dependent ATPase activity|helicase activity|histone acetyl-lysine binding|identical protein binding|p53 binding|protein N-terminus binding|transcription corepressor activity	p.?(1)		adrenal_gland(1)|autonomic_ganglia(1)|breast(6)|central_nervous_system(23)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(16)|liver(4)|lung(60)|ovary(10)|pancreas(7)|prostate(3)|skin(8)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	163		all_lung(6;0.0512)|Lung NSC(9;0.0568)				TGGACTTCAAGAAGATAAAGG	0.617000			"""F, N, Mis"""		NSCLC								5	8					0	0	0.217242	0	0
CROCCP2	84809	broad.mit.edu	37	1	16960418	16960418	+	RNA	DEL	A	A	-	rs59476808		TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr1:16960418delA	ENST00000412962.1	-	0	16																											tcagattgggaaaaaaaaaaa	0.453													6	2	---	---	---	---					
ESPNP	284729	broad.mit.edu	37	1	17034125	17034126	+	RNA	INS	-	-	AGCT	rs141324796	by1000genomes	TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr1:17034125_17034126insAGCT	ENST00000492551.1	-	0	477_478					NR_026567.1																						CAGCAGCAGCCAGCTGAGCACC	0.718													3	6	---	---	---	---					
RP5-1198O20.4	0	broad.mit.edu	37	1	44538882	44538882	+	RNA	DEL	T	T	-			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr1:44538882delT	ENST00000434244.1	+	0	930																											cttcttcttcttttttttttt	0.438													3	5	---	---	---	---					
RP11-191G24.1	0	broad.mit.edu	37	1	52015539	52015540	+	RNA	INS	-	-	T	rs138950220	by1000genomes	TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr1:52015539_52015540insT	ENST00000426017.1	+	0	64				RP11-191G24.1_ENST00000415031.1_RNA																							TTAAAAAGGCATTTTTTTTCCA	0.406													5	5	---	---	---	---					
RP11-776H12.1	0	broad.mit.edu	37	1	61077803	61077803	+	RNA	DEL	A	A	-			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr1:61077803delA	ENST00000439156.2	-	0	336																											gtagtctcagaaaatgtttgA	0.383													2	4	---	---	---	---					
LOC101926964	101926964	broad.mit.edu	37	1	61224001	61224001	+	RNA	DEL	G	G	-	rs34667384		TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr1:61224001delG	ENST00000423403.1	-	0	249																											AGGGTTGGAAGGTTACTGAAA	0.408													2	4	---	---	---	---					
GNG12-AS1	100289178	broad.mit.edu	37	1	68442771	68442772	+	RNA	INS	-	-	T			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr1:68442771_68442772insT	ENST00000420587.1	+	0	134				GNG12-AS1_ENST00000413628.1_RNA|GNG12-AS1_ENST00000414904.1_RNA	NR_040077.1		Q6ZVV5	Q6ZVV5_HUMAN																			AGACTCAGTGATTTTTTTTGGC	0.411													2	4	---	---	---	---					
LOC101927244	101927244	broad.mit.edu	37	1	71172636	71172636	+	RNA	DEL	G	G	-			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr1:71172636delG	ENST00000419450.1	+	0	79																											ttcttatttagggccacgggt	0.512													2	4	---	---	---	---					
MGC27382	149047	broad.mit.edu	37	1	78754877	78754878	+	RNA	INS	-	-	A			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr1:78754877_78754878insA	ENST00000436742.1	+	0	1342																											ATTTAATACTCAAAACAAATAG	0.337													2	4	---	---	---	---					
RP5-947P14.1	0	broad.mit.edu	37	1	106621106	106621107	+	RNA	INS	-	-	A			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr1:106621106_106621107insA	ENST00000437803.1	+	0	165																											tttctcctaccaaaaaaaaaat	0.391													2	4	---	---	---	---					
NBPF18P	441908	broad.mit.edu	37	1	152001835	152001836	+	RNA	INS	-	-	C			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr1:152001835_152001836insC	ENST00000432386.1	+	0	2919					NR_103561.1																						ttttcgctttgccccccCGGCA	0.510													2	4	---	---	---	---					
RP11-306I1.2	0	broad.mit.edu	37	1	165587190	165587190	+	RNA	DEL	G	G	-	rs112121335		TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr1:165587190delG	ENST00000452618.1	+	0	315																											ctccagaactgtgagcagtaa	0.458													4	4	---	---	---	---					
LINC00626	79100	broad.mit.edu	37	1	168760767	168760768	+	RNA	DEL	CA	CA	-	rs72119337		TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr1:168760767_168760768delCA	ENST00000420691.1	+	0	399					NR_024160.1																						CTATCTTTATcacacacacaca	0.470													4	8	---	---	---	---					
LINC00970	101978719	broad.mit.edu	37	1	168917466	168917469	+	RNA	DEL	GAAA	GAAA	-	rs2900959		TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr1:168917466_168917469delGAAA	ENST00000366408.3	-	0	209																											ACCTCTGATGGAAAGAGAGTGAAA	0.407													3	5	---	---	---	---					
LINC00970	101978719	broad.mit.edu	37	1	168949453	168949459	+	RNA	DEL	CTCTCCC	CTCTCCC	-	rs2984591		TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr1:168949453_168949459delCTCTCCC	ENST00000366408.3	-	0	209																											catatgcactctctcccctctccttgg	0.483													4	2	---	---	---	---					
LOC102724601	102724601	broad.mit.edu	37	1	174104835	174104835	+	RNA	DEL	T	T	-	rs75165126		TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr1:174104835delT	ENST00000426899.1	-	0	338																											aagttgctcctcctaaaattt	0.388													4	5	---	---	---	---					
LINC01344	400799	broad.mit.edu	37	1	182203484	182203487	+	RNA	DEL	AAAC	AAAC	-	rs71958642		TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr1:182203484_182203487delAAAC	ENST00000449842.1	-	0	410																											ctccttctcaaaacaaacaaacaa	0.436													4	5	---	---	---	---					
LINC01036	104169671	broad.mit.edu	37	1	187109043	187109043	+	RNA	DEL	T	T	-			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr1:187109043delT	ENST00000458683.1	+	0	105																											ggaggctttgtttgtttcttt	0.348													2	4	---	---	---	---					
RP1-272L16.1	0	broad.mit.edu	37	1	209708265	209708266	+	RNA	INS	-	-	T	rs111400425		TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr1:209708265_209708266insT	ENST00000424696.2	-	0	510																											CTCATTCATAGTTTTTTTTTTT	0.337													2	4	---	---	---	---					
RP11-400N13.1	0	broad.mit.edu	37	1	222427460	222427460	+	RNA	DEL	G	G	-			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr1:222427460delG	ENST00000416510.1	-	0	167																											tcttgctggtgcccaaaagcg	0.592													2	4	---	---	---	---					
AC099344.2	0	broad.mit.edu	37	2	11499077	11499078	+	RNA	DEL	TT	TT	-	rs59829548		TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr2:11499077_11499078delTT	ENST00000430897.1	-	0	539																											tctttctttctttttttttttt	0.411													3	3	---	---	---	---					
LOC100506457	100506457	broad.mit.edu	37	2	12508919	12508920	+	RNA	INS	-	-	A	rs138761982	by1000genomes	TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr2:12508919_12508920insA	ENST00000412294.1	+	0	412																											GGAATGGCTTGAAAATGAGAAG	0.525													3	4	---	---	---	---					
AC008278.2	0	broad.mit.edu	37	2	15708783	15708783	+	RNA	DEL	T	T	-	rs146500001		TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr2:15708783delT	ENST00000438178.1	+	0	239																											AACCTCCCCCttttttttttt	0.493													2	4	---	---	---	---					
AC068490.2	0	broad.mit.edu	37	2	22727661	22727661	+	RNA	DEL	A	A	-	rs34525150		TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr2:22727661delA	ENST00000450551.1	-	0	70																											aggaaaagagaaaaaaaattg	0.363													3	3	---	---	---	---					
LINC01317	104355287	broad.mit.edu	37	2	34248909	34248909	+	RNA	DEL	C	C	-			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr2:34248909delC	ENST00000366209.2	+	0	389																											tagcctgagtccctgaaagaa	0.418													2	4	---	---	---	---					
SLC8A1-AS1	100128590	broad.mit.edu	37	2	40141569	40141570	+	RNA	DEL	TT	TT	-	rs149623182		TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr2:40141569_40141570delTT	ENST00000599740.1	+	0	73																											TGTATGACACTTTTTTTTTTTT	0.431													4	1	---	---	---	---					
RP11-444A22.1	0	broad.mit.edu	37	2	60225778	60225779	+	RNA	INS	-	-	A			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr2:60225778_60225779insA	ENST00000606382.1	-	0	110																											TTATTTTTCAGAAAAAAAAAAA	0.351													2	4	---	---	---	---					
LOC644838	644838	broad.mit.edu	37	2	67395985	67395985	+	RNA	DEL	T	T	-	rs71970559		TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr2:67395985delT	ENST00000433133.1	-	0	205				AC023115.1_ENST00000594329.1_lincRNA|AC023115.2_ENST00000452716.1_lincRNA	NR_038844.1																						taatctcctcttttttttttt	0.408													3	3	---	---	---	---					
AC084193.1	0	broad.mit.edu	37	2	80996898	80996899	+	RNA	INS	-	-	TT			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr2:80996898_80996899insTT	ENST00000450290.1	-	0	468																											GCACGCTAACATTTTTAAGTGC	0.277													2	4	---	---	---	---					
AC006227.1	0	broad.mit.edu	37	2	107887917	107887917	+	RNA	DEL	T	T	-			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr2:107887917delT	ENST00000443123.1	-	0	394																											gagactttacttttttttttg	0.328													2	4	---	---	---	---					
AC012501.2	0	broad.mit.edu	37	2	154413547	154413548	+	RNA	INS	-	-	C			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr2:154413547_154413548insC	ENST00000424322.1	-	0	429																											cacaaatttgacccccccttcc	0.376													3	6	---	---	---	---					
AC012501.2	0	broad.mit.edu	37	2	154418511	154418512	+	RNA	INS	-	-	CC	rs61709877	by1000genomes	TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr2:154418511_154418512insCC	ENST00000424322.1	-	0	429																											TCACACTTTTGCCCCTTTTCTT	0.366													6	3	---	---	---	---					
AC016723.4	0	broad.mit.edu	37	2	168760146	168760147	+	RNA	DEL	AG	AG	-			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr2:168760146_168760147delAG	ENST00000436982.2	-	0	36																											ACTgagagacagagagagagag	0.416													2	4	---	---	---	---					
AC016723.4	0	broad.mit.edu	37	2	168783630	168783630	+	RNA	DEL	T	T	-			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr2:168783630delT	ENST00000436982.2	-	0	36																											acctttggtgttttttttttt	0.532													3	3	---	---	---	---					
AC016751.3	0	broad.mit.edu	37	2	176768229	176768229	+	RNA	DEL	G	G	-			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr2:176768229delG	ENST00000453206.1	+	0	151																											TTAAATGAAAGGACAGTAGAA	0.363													5	3	---	---	---	---					
AC079305.11	0	broad.mit.edu	37	2	178021843	178021843	+	RNA	DEL	A	A	-	rs75195888		TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr2:178021843delA	ENST00000441205.1	-	0	169				AC079305.8_ENST00000455416.1_RNA																							gtctcaaaagaaaaaaaaaaa	0.517													2	4	---	---	---	---					
LOC101927865	101927865	broad.mit.edu	37	2	208086822	208086823	+	RNA	INS	-	-	A	rs71036908	by1000genomes	TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr2:208086822_208086823insA	ENST00000448786.1	-	0	665				AC007879.1_ENST00000435643.1_lincRNA																							ACACTTTCCACAAAAAAAGAAA	0.450													3	5	---	---	---	---					
AC007879.5	0	broad.mit.edu	37	2	208115341	208115342	+	RNA	INS	-	-	T			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr2:208115341_208115342insT	ENST00000432413.2	-	0	64				AC007879.5_ENST00000412387.1_RNA																							GAAAATATGACTTTTTTTTACT	0.287													2	4	---	---	---	---					
AC007879.5	0	broad.mit.edu	37	2	208333078	208333079	+	RNA	DEL	AC	AC	-	rs111616590		TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr2:208333078_208333079delAC	ENST00000418850.1	-	0	256				AC007879.5_ENST00000412387.1_RNA																							ctctgccaagacacacacacac	0.550													2	4	---	---	---	---					
AC007563.5	0	broad.mit.edu	37	2	217684791	217684791	+	RNA	DEL	G	G	-			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr2:217684791delG	ENST00000447289.1	+	0	510																											GTGGGGGTGTGGGGTGGGCAG	0.547													2	4	---	---	---	---					
AC067956.1	0	broad.mit.edu	37	2	221351707	221351708	+	RNA	DEL	AG	AG	-			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr2:221351707_221351708delAG	ENST00000414512.1	+	0	368																											agacagagacagagagagagag	0.436													4	4	---	---	---	---					
LINC01266	101927215	broad.mit.edu	37	3	701165	701166	+	RNA	INS	-	-	AGACAC	rs2729263		TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr3:701165_701166insAGACAC	ENST00000420823.1	+	0	176																											TGCTATTTTTGacacacacaca	0.401													4	3	---	---	---	---					
AC027119.1	0	broad.mit.edu	37	3	6125262	6125263	+	RNA	INS	-	-	C			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr3:6125262_6125263insC	ENST00000425894.1	+	0	322																											TTTTCTGACCACCCCCCCATCA	0.431													2	4	---	---	---	---					
LMCD1-AS1	100288428	broad.mit.edu	37	3	8206105	8206106	+	RNA	DEL	AC	AC	-			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr3:8206105_8206106delAC	ENST00000446281.1	-	0	514																											tgaacacctgacacacacacac	0.371													3	3	---	---	---	---					
EMC3-AS1	442075	broad.mit.edu	37	3	10031713	10031713	+	RNA	DEL	T	T	-	rs75974954		TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr3:10031713delT	ENST00000326237.3	+	0	354																											GTGttttctcttttttttttg	0.438													2	4	---	---	---	---					
SATB1-AS1	101927777	broad.mit.edu	37	3	18557906	18557906	+	RNA	DEL	T	T	-			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr3:18557906delT	ENST00000593741.1	+	0	234				AC144521.1_ENST00000598498.1_RNA|AC144521.1_ENST00000456253.2_RNA|AC144521.1_ENST00000595865.1_RNA|AC144521.1_ENST00000595250.1_RNA|AC144521.1_ENST00000599762.1_RNA|AC144521.1_ENST00000593444.1_RNA|AC144521.1_ENST00000595388.1_RNA|AC144521.1_ENST00000414198.1_RNA|AC144521.1_ENST00000596307.1_RNA|AC144521.1_ENST00000596277.1_RNA|AC144521.1_ENST00000598740.1_RNA|AC144521.1_ENST00000598390.1_RNA|AC144521.1_ENST00000598688.1_RNA|AC144521.1_ENST00000596850.1_RNA																							catcacaagattatatccctc	0.542													2	4	---	---	---	---					
AC133680.1	0	broad.mit.edu	37	3	24771639	24771639	+	RNA	DEL	T	T	-			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr3:24771639delT	ENST00000455576.1	+	0	77																											aggcaagccatttcatgcttc	0.333													2	4	---	---	---	---					
LINC00693	645206	broad.mit.edu	37	3	28743882	28743882	+	RNA	DEL	T	T	-	rs34860168		TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr3:28743882delT	ENST00000432518.2	+	0	809				LINC00693_ENST00000443912.1_RNA|LINC00693_ENST00000445077.1_RNA	NR_038840.1																						TGTATCACACttttttttttt	0.448													3	4	---	---	---	---					
SCN10A	6336	broad.mit.edu	37	3	38770107	38770107	+	Frame_Shift_Del	DEL	C	C	-			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr3:38770107delC	ENST00000449082.2	-	15	2565	c.2566delG	c.(2566-2568)ccfs	p.A856fs		NM_006514.2	NP_006505.2	Q9Y5Y9	SCNAA_HUMAN	sodium channel, voltage-gated, type X, alpha subunit	856					sensory perception	voltage-gated sodium channel complex		p.A856S(2)		NS(5)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(14)|kidney(5)|large_intestine(33)|lung(54)|ovary(5)|pancreas(1)|prostate(5)|skin(13)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	150				KIRC - Kidney renal clear cell carcinoma(284;0.0769)|Kidney(284;0.0945)	Benzocaine(DB01086)|Bupivacaine(DB00297)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dibucaine(DB00527)|Dyclonine(DB00645)|Hexylcaine(DB00473)|Levobupivacaine(DB01002)|Lidocaine(DB00281)|Mepivacaine(DB00961)|Oxybuprocaine(DB00892)|Procaine(DB00721)|Proparacaine(DB00807)|Ropivacaine(DB00296)	TCCATGCAGGCCCACATGTTC	0.542													32	56	---	---	---	---					
LINC01471	101927149	broad.mit.edu	37	3	127201092	127201092	+	RNA	DEL	A	A	-	rs79869690		TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr3:127201092delA	ENST00000461398.2	-	0	2354																											actccgtctcaaaaaaaaaaa	0.443													2	4	---	---	---	---					
RP11-93K22.6	0	broad.mit.edu	37	3	129684110	129684117	+	RNA	DEL	TTTTTTTT	TTTTTTTT	-	rs143027909		TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr3:129684110_129684117delTTTTTTTT	ENST00000509201.1	-	0	200																											agtcattccctttttttttttttttttt	0.433													2	4	---	---	---	---					
PAQR9-AS1	101927832	broad.mit.edu	37	3	142708840	142708840	+	RNA	DEL	T	T	-			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr3:142708840delT	ENST00000595248.1	+	0	140				RP11-372E1.6_ENST00000598139.1_RNA|RP11-372E1.6_ENST00000595774.1_RNA|RP11-372E1.6_ENST00000598787.1_RNA|RP11-372E1.6_ENST00000497652.1_RNA																							gtttcttttcttttttttttt	0.418													3	5	---	---	---	---					
AADACL2-AS1	101928142	broad.mit.edu	37	3	151517411	151517411	+	RNA	DEL	A	A	-			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr3:151517411delA	ENST00000483843.2	-	0	439				RP11-454C18.2_ENST00000475855.1_RNA|RP11-64D22.5_ENST00000485020.1_lincRNA																							AGCTGAAAGGAAATTCTTCCC	0.368													2	4	---	---	---	---					
RP11-439C8.1	0	broad.mit.edu	37	3	154570838	154570839	+	RNA	INS	-	-	A			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr3:154570838_154570839insA	ENST00000478814.1	-	0	226																											TGGTAACTAACAAAAATGTTAA	0.342													2	4	---	---	---	---					
LINC00578	100505566	broad.mit.edu	37	3	177408204	177408208	+	RNA	DEL	AAAAC	AAAAC	-	rs56958874		TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr3:177408204_177408208delAAAAC	ENST00000442937.1	+	0	428				RP11-114M1.1_ENST00000423466.2_lincRNA	NR_047568.1																						GGAGCAAACTaaaacaaaacaaaac	0.356													2	4	---	---	---	---					
LINC01085	152742	broad.mit.edu	37	4	14129355	14129355	+	RNA	DEL	A	A	-			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr4:14129355delA	ENST00000502759.1	+	0	392					NR_033931.1																						ACCAGATATTAAGGGGCTTAT	0.498													2	4	---	---	---	---					
RP11-685F15.1	0	broad.mit.edu	37	4	58467334	58467334	+	RNA	DEL	T	T	-			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr4:58467334delT	ENST00000509641.2	-	0	207																											TGTAAAGGTGTTTTTTTTTTG	0.353													3	4	---	---	---	---					
UBA6-AS1	550112	broad.mit.edu	37	4	68669947	68669948	+	RNA	DEL	TG	TG	-			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr4:68669947_68669948delTG	ENST00000500538.2	+	0	1905																											tgtgtgtatttgtgtgtgtgtg	0.450													2	4	---	---	---	---					
RP11-703G6.1	0	broad.mit.edu	37	4	104891231	104891232	+	RNA	DEL	TA	TA	-			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr4:104891231_104891232delTA	ENST00000510505.1	+	0	63																											TCAGAAAAAGTATGTTGGAGTT	0.302													2	4	---	---	---	---					
RP11-703G6.1	0	broad.mit.edu	37	4	104926869	104926870	+	RNA	INS	-	-	G			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr4:104926869_104926870insG	ENST00000510505.1	+	0	180																											TGAAAATGGCAGGAATTTTAAA	0.347													2	4	---	---	---	---					
AC108056.1	0	broad.mit.edu	37	4	118781041	118781042	+	RNA	INS	-	-	C	rs60842861		TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr4:118781041_118781042insC	ENST00000442020.1	+	0	86																											aacctaattttttttttttttt	0.436													3	4	---	---	---	---					
RP11-153M7.3	0	broad.mit.edu	37	4	154567112	154567113	+	RNA	INS	-	-	G	rs60735082		TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr4:154567112_154567113insG	ENST00000602666.1	+	0	355																											TTTTCTGGGGAGGGGGGGTACT	0.386													2	4	---	---	---	---					
LOC100506085	100506085	broad.mit.edu	37	4	170889145	170889146	+	RNA	INS	-	-	T			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr4:170889145_170889146insT	ENST00000508313.1	-	0	87					NR_037878.1																						tactgatttccttttttggata	0.381													2	4	---	---	---	---					
LOC728339	728339	broad.mit.edu	37	4	190797948	190797949	+	RNA	INS	-	-	G	rs113816091		TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr4:190797948_190797949insG	ENST00000511785.1	-	0	231																											TTGATATGTTTGAGAGTGAGGT	0.495													3	5	---	---	---	---					
LOC728339	728339	broad.mit.edu	37	4	190808280	190808280	+	RNA	DEL	C	C	-			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr4:190808280delC	ENST00000511785.1	-	0	231																											GAAAGGCAGGCTTAGCCAAGT	0.428													7	5	---	---	---	---					
CTD-2287N17.1	0	broad.mit.edu	37	5	4013381	4013382	+	RNA	INS	-	-	C	rs35342350	by1000genomes	TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr5:4013381_4013382insC	ENST00000513859.1	-	0	275																											AAAGACAGCAGCCCCCTCCCTC	0.663													10	16	---	---	---	---					
RP11-445O3.2	0	broad.mit.edu	37	5	4586024	4586025	+	RNA	DEL	AC	AC	-			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr5:4586024_4586025delAC	ENST00000507435.1	-	0	429																											atgcatgcaaacacacacacac	0.411													3	4	---	---	---	---					
LINC01020	340094	broad.mit.edu	37	5	5047962	5047962	+	RNA	DEL	C	C	-	rs11320899		TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr5:5047962delC	ENST00000508201.1	+	0	308				CTD-2247C11.4_ENST00000511514.1_lincRNA																							TGTTTTCAAGCCTCCATTGCA	0.343													4	3	---	---	---	---					
RP11-122F24.1	0	broad.mit.edu	37	5	6988595	6988602	+	RNA	DEL	GTGTGTGT	GTGTGTGT	-	rs71736379		TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr5:6988595_6988602delGTGTGTGT	ENST00000512838.1	+	0	69																											acacacacacgtgtgtgtgtgtgtgtgt	0.433													4	1	---	---	---	---					
LOC729506	729506	broad.mit.edu	37	5	8419164	8419165	+	RNA	DEL	CA	CA	-	rs55748425		TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr5:8419164_8419165delCA	ENST00000501071.1	-	0	168				RP11-480D4.2_ENST00000512406.1_lincRNA	NR_039984.1																						aacccccccccaaaaaaaaaaa	0.495													2	4	---	---	---	---					
LOC285692	285692	broad.mit.edu	37	5	9858490	9858490	+	RNA	DEL	C	C	-			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr5:9858490delC	ENST00000511616.1	-	0	521				RP11-447B18.1_ENST00000508097.1_lincRNA	NR_027112.2																						tctctcctttccccaagtgaa	0.522													2	4	---	---	---	---					
LOC102723526	102723526	broad.mit.edu	37	5	17463670	17463670	+	RNA	DEL	G	G	-	rs58919162		TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr5:17463670delG	ENST00000504998.1	+	0	225																											gtgcttctctgggggggaacc	0.562													4	2	---	---	---	---					
RP11-774D14.1	0	broad.mit.edu	37	5	20737962	20737962	+	RNA	DEL	A	A	-			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr5:20737962delA	ENST00000502427.1	+	0	395																											AAGCACAAAGAAAAAAAAAAG	0.308													2	4	---	---	---	---					
CTD-2066L21.3	0	broad.mit.edu	37	5	33217955	33217955	+	RNA	DEL	A	A	-			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr5:33217955delA	ENST00000510327.1	-	0	346																											TTACTCTCCTAAAAAAAAAAA	0.333													2	4	---	---	---	---					
CTD-2194L12.2	0	broad.mit.edu	37	5	37914133	37914134	+	RNA	INS	-	-	T	rs150600092		TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr5:37914133_37914134insT	ENST00000513673.1	-	0	234																											ATTTTCTGGGCTTTTTTTTTTT	0.450													2	4	---	---	---	---					
LINC01265	101926904	broad.mit.edu	37	5	38719506	38719507	+	RNA	DEL	GT	GT	-	rs111374163		TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr5:38719506_38719507delGT	ENST00000506463.1	-	0	89																											GCCTCATtgcgtgtgtgtgtgt	0.401													3	3	---	---	---	---					
CTD-2023N9.1	0	broad.mit.edu	37	5	56744210	56744211	+	RNA	INS	-	-	T			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr5:56744210_56744211insT	ENST00000506106.1	+	0	119																											TTAAAAAGCCATTTTTTTTCCC	0.495													2	4	---	---	---	---					
CTD-2275D24.1	0	broad.mit.edu	37	5	73628995	73628996	+	RNA	INS	-	-	A			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr5:73628995_73628996insA	ENST00000512458.1	+	0	227				CTD-2275D24.3_ENST00000506612.1_lincRNA																							atttgccatTTAAAAATTAGAC	0.386													2	4	---	---	---	---					
CTD-2503O16.4	0	broad.mit.edu	37	5	74250811	74250811	+	RNA	DEL	A	A	-	rs13156811		TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr5:74250811delA	ENST00000505200.1	-	0	335																											aaagaaaaagaaaaaaaaaTG	0.418													2	4	---	---	---	---					
LOC102546226	102546226	broad.mit.edu	37	5	87733222	87733222	+	RNA	DEL	T	T	-	rs74956633		TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr5:87733222delT	ENST00000506041.2	-	0	106				CTC-498M16.4_ENST00000504034.2_lincRNA																							ATGTCACGGATTTTTTTTTTT	0.373													3	3	---	---	---	---					
RP11-116A1.1	0	broad.mit.edu	37	5	88961553	88961556	+	RNA	DEL	TATC	TATC	-			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr5:88961553_88961556delTATC	ENST00000503691.1	+	0	168																											atctgtctattatctatctatcta	0.328													2	4	---	---	---	---					
NR2F1-AS1	441094	broad.mit.edu	37	5	92757073	92757074	+	RNA	DEL	AA	AA	-	rs34159028		TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr5:92757073_92757074delAA	ENST00000607797.1	-	0	1229				NR2F1-AS1_ENST00000606739.1_RNA|NR2F1-AS1_ENST00000606165.1_RNA|NR2F1-AS1_ENST00000510254.1_RNA|NR2F1-AS1_ENST00000607195.1_RNA|NR2F1-AS1_ENST00000607112.1_RNA|NR2F1-AS1_ENST00000606233.1_RNA|NR2F1-AS1_ENST00000607831.1_RNA|NR2F1-AS1_ENST00000606188.1_RNA	NR_015369.1																						CTTTTGAGTTAAAAAAAAAAAA	0.351													2	4	---	---	---	---					
RP11-254I22.1	0	broad.mit.edu	37	5	95472074	95472075	+	RNA	INS	-	-	T			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr5:95472074_95472075insT	ENST00000507997.1	+	0	159				CTD-2337A12.1_ENST00000511775.1_RNA|CTD-2337A12.1_ENST00000502645.2_RNA																							gttttgttttgtttttgagcac	0.406													2	4	---	---	---	---					
LOC101927379	101927379	broad.mit.edu	37	5	122034411	122034411	+	RNA	DEL	A	A	-			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr5:122034411delA	ENST00000511194.1	-	0	749																											ctgtctcgagaaaaaaaaaaa	0.388													2	4	---	---	---	---					
CTB-57H20.1	0	broad.mit.edu	37	5	143102968	143102968	+	RNA	DEL	T	T	-			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr5:143102968delT	ENST00000503323.1	+	0	379																											tgtttgaatgttttttatttc	0.403													2	4	---	---	---	---					
LOC101927115	101927115	broad.mit.edu	37	5	151554637	151554638	+	RNA	INS	-	-	C			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr5:151554637_151554638insC	ENST00000524295.1	+	0	199																											cccttccctagccccccaccct	0.465													2	4	---	---	---	---					
CTB-11I22.1	0	broad.mit.edu	37	5	158644321	158644322	+	RNA	INS	-	-	C	rs143588247	by1000genomes	TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr5:158644321_158644322insC	ENST00000521204.1	+	0	191																											agagtctctgaccccaagacct	0.450													2	4	---	---	---	---					
RP11-541P9.3	0	broad.mit.edu	37	5	162843179	162843180	+	RNA	INS	-	-	C			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr5:162843179_162843180insC	ENST00000503504.1	-	0	355				RP11-541P9.3_ENST00000458002.2_RNA																							CCTTGCTTTTTCCCCCCAGTAC	0.361													2	4	---	---	---	---					
LINC01411	101928176	broad.mit.edu	37	5	173808289	173808290	+	RNA	DEL	GT	GT	-	rs33932378		TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr5:173808289_173808290delGT	ENST00000510234.1	+	0	82																											TTCAGTAGGGgtgtgtgtgtgt	0.480													4	7	---	---	---	---					
GMDS-AS1	100508120	broad.mit.edu	37	6	2402912	2402913	+	RNA	DEL	AA	AA	-	rs79691267		TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr6:2402912_2402913delAA	ENST00000505870.1	+	0	7405																											actctgtctcaaaaaaaaaaaa	0.411													2	4	---	---	---	---					
LY86-AS1	285780	broad.mit.edu	37	6	6423743	6423743	+	RNA	DEL	A	A	-			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr6:6423743delA	ENST00000435641.1	-	0	639				LY86-AS1_ENST00000429345.1_RNA|LY86-AS1_ENST00000447858.1_RNA																							cttctcctccaaaaacttggg	0.537													2	4	---	---	---	---					
ZNRD1-AS1	80862	broad.mit.edu	37	6	30022667	30022668	+	RNA	INS	-	-	A	rs34274514		TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr6:30022667_30022668insA	ENST00000431012.1	-	0	3003_3004				ZNRD1-AS1_ENST00000448093.1_RNA|ZNRD1-AS1_ENST00000437417.1_RNA|ZNRD1-AS1_ENST00000421692.1_RNA|ZNRD1-AS1_ENST00000422224.1_RNA|ZNRD1-AS1_ENST00000425604.1_RNA|ZNRD1-AS1_ENST00000420251.1_RNA|ZNRD1-AS1_ENST00000376797.3_RNA																							GAAAAAAGACCAAAAAAAAAAC	0.317													4	5	---	---	---	---					
HCG20	414774	broad.mit.edu	37	6	30735656	30735656	+	RNA	DEL	T	T	-			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr6:30735656delT	ENST00000439406.1	+	0	127																											catgaactgcttttttttttt	0.507													2	4	---	---	---	---					
RP11-631F7.2	0	broad.mit.edu	37	6	148457920	148457921	+	RNA	DEL	CA	CA	-			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr6:148457920_148457921delCA	ENST00000417838.1	-	0	96																											GTCCCATGAGCACACACACACA	0.475													3	6	---	---	---	---					
RP1-249F5.3	0	broad.mit.edu	37	6	160322886	160322886	+	RNA	DEL	A	A	-	rs35452379		TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr6:160322886delA	ENST00000434562.1	+	0	207																											ccctatctctaaaaaaaaaaa	0.388													3	4	---	---	---	---					
RP11-347L18.1	0	broad.mit.edu	37	6	164769216	164769217	+	RNA	INS	-	-	CA	rs71023270	by1000genomes	TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr6:164769216_164769217insCA	ENST00000434356.1	-	0	345																											ccacagacacgcacacacacac	0.436													6	5	---	---	---	---					
AC004485.3	0	broad.mit.edu	37	7	24252575	24252575	+	RNA	DEL	G	G	-			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr7:24252575delG	ENST00000439839.1	-	0	159																											GAGAAGACTTggggggctggt	0.463													2	4	---	---	---	---					
AC004009.3	0	broad.mit.edu	37	7	27446565	27446566	+	RNA	INS	-	-	GATGT	rs149252430	by1000genomes	TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr7:27446565_27446566insGATGT	ENST00000412413.1	+	0	399																											aggagtccagggagcagcctct	0.550													2	4	---	---	---	---					
NPSR1-AS1	404744	broad.mit.edu	37	7	34529296	34529296	+	RNA	DEL	G	G	-			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr7:34529296delG	ENST00000419766.1	-	0	310					NR_033664.1|NR_033665.1																						ccttaaagcaggggggtgggt	0.423													2	4	---	---	---	---					
AC004901.1	0	broad.mit.edu	37	7	47062444	47062445	+	RNA	INS	-	-	A	rs112640301	by1000genomes	TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr7:47062444_47062445insA	ENST00000433337.1	-	0	237				AC004870.3_ENST00000412996.1_RNA																							TCTTGTCCCTTACGTCCCCAGG	0.485													7	7	---	---	---	---					
RP5-945F2.2	0	broad.mit.edu	37	7	67568994	67568995	+	RNA	INS	-	-	A			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr7:67568994_67568995insA	ENST00000424888.2	+	0	103																											agaaggtcagcaaaaaacgtga	0.386													2	4	---	---	---	---					
RP5-945F2.3	0	broad.mit.edu	37	7	67733006	67733007	+	RNA	DEL	AG	AG	-			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr7:67733006_67733007delAG	ENST00000446187.1	-	0	179																											ttgtatttttagtagagacggg	0.535													2	4	---	---	---	---					
TYW1B	441250	broad.mit.edu	37	7	72233924	72233924	+	RNA	DEL	C	C	-			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr7:72233924delC	ENST00000438125.1	-	0	577							Q6NUM6	TYW1B_HUMAN	tRNA-yW synthesizing protein 1 homolog B (S. cerevisiae)						tRNA processing		4 iron, 4 sulfur cluster binding|FMN binding|iron ion binding|oxidoreductase activity										TTGAATTTTGCAAACCACCTC	0.363													4	6	---	---	---	---					
RP11-560I19.1	0	broad.mit.edu	37	7	121858099	121858100	+	RNA	INS	-	-	G	rs150662047	by1000genomes	TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr7:121858099_121858100insG	ENST00000446053.1	+	0	176																											aaatggggagtgggggggtggg	0.455													4	7	---	---	---	---					
TAS2R40	259286	broad.mit.edu	37	7	142919176	142919177	+	Frame_Shift_Ins	INS	-	-	A			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr7:142919176_142919177insA	ENST00000408947.3	+	1	47_48	c.5_6insA	c.(4-6)gacfs	p.D2fs	AC073342.1_ENST00000595842.1_Frame_Shift_Ins_p.P62fs	NM_176882.1	NP_795363.1	P59535	T2R40_HUMAN	taste receptor, type 2, member 40	2					sensory perception of taste	integral to membrane	G-protein coupled receptor activity			kidney(1)|large_intestine(1)|lung(4)|ovary(1)|prostate(1)	8	Melanoma(164;0.059)					AAGAGAATGGCAACGGTGAACA	0.470													36	147	---	---	---	---					
RP11-108E14.1	0	broad.mit.edu	37	8	20527650	20527651	+	RNA	INS	-	-	G	rs149726441	by1000genomes	TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr8:20527650_20527651insG	ENST00000517706.1	-	0	195																											AGAGCTGGTGAGGGGGTGTCAT	0.490													3	3	---	---	---	---					
RP11-624C23.1	0	broad.mit.edu	37	8	24552858	24552858	+	RNA	DEL	T	T	-			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr8:24552858delT	ENST00000519689.1	-	0	184																											ggaggattgcttgaatttggg	0.428													2	4	---	---	---	---					
RP11-624C23.1	0	broad.mit.edu	37	8	24663877	24663878	+	RNA	INS	-	-	G			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr8:24663877_24663878insG	ENST00000519689.1	-	0	184																											CTTTCTTTTTTGGGGAAAGCAA	0.366													2	4	---	---	---	---					
RP11-11N9.4	0	broad.mit.edu	37	8	32894675	32894676	+	RNA	INS	-	-	T	rs5890698	by1000genomes	TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr8:32894675_32894676insT	ENST00000500843.2	+	0	139																											TGTGGCCCTGCTTTTCATCCTT	0.391													2	4	---	---	---	---					
LOC100507420	100507420	broad.mit.edu	37	8	37337223	37337223	+	RNA	DEL	G	G	-			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr8:37337223delG	ENST00000522718.1	-	0	476																											CAGGACAGGTGGGGAACAGTC	0.582													2	4	---	---	---	---					
RP11-150O12.4	0	broad.mit.edu	37	8	37479619	37479620	+	RNA	INS	-	-	T	rs71839475		TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr8:37479619_37479620insT	ENST00000517714.1	-	0	135																											ttttcttttggttttttttttt	0.446													4	2	---	---	---	---					
RP11-120I21.2	0	broad.mit.edu	37	8	85034983	85034983	+	RNA	DEL	G	G	-			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr8:85034983delG	ENST00000523678.1	+	0	279																											GCAAGTGGGTGGAGGCAGACC	0.368													2	4	---	---	---	---					
RP11-586K2.1	0	broad.mit.edu	37	8	89372032	89372032	+	RNA	DEL	G	G	-			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr8:89372032delG	ENST00000521433.1	+	0	179				RP11-586K2.1_ENST00000523254.1_RNA																							aactgcatctggtgacggcat	0.413													2	4	---	---	---	---					
FLJ46284	441369	broad.mit.edu	37	8	93881662	93881662	+	RNA	DEL	A	A	-	rs78484749		TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr8:93881662delA	ENST00000504861.2	-	0	55					NR_046114.1																						actctgtctcaaaaaaaaaaa	0.448													2	4	---	---	---	---					
KB-173C10.2	0	broad.mit.edu	37	8	101411779	101411784	+	RNA	DEL	ACACAC	ACACAC	-	rs72185197		TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr8:101411779_101411784delACACAC	ENST00000519844.1	-	0	132																											caacacacaaacacacacacacacac	0.461													2	4	---	---	---	---					
LINC01591	286094	broad.mit.edu	37	8	136252677	136252677	+	RNA	DEL	T	T	-			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr8:136252677delT	ENST00000522279.1	+	0	384					NR_026706.1																						gattctgagattagcaggtga	0.448													2	4	---	---	---	---					
RP11-149P24.1	0	broad.mit.edu	37	8	137067374	137067375	+	RNA	INS	-	-	A	rs145055640		TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr8:137067374_137067375insA	ENST00000523150.1	+	0	159																											acaaaaaatgcaaaaaaaaaaa	0.455													4	4	---	---	---	---					
MIR31HG	554202	broad.mit.edu	37	9	21516477	21516477	+	RNA	DEL	G	G	-			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr9:21516477delG	ENST00000304425.3	-	0	181					NR_027054.1																						AAGGGAAGGTGGGGGATGAGG	0.358													5	5	---	---	---	---					
B4GALT1-AS1	101929639	broad.mit.edu	37	9	33176639	33176639	+	RNA	DEL	G	G	-			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr9:33176639delG	ENST00000442432.1	+	0	72				RP11-326F20.5_ENST00000426270.1_RNA																							accgataagtgggagctagac	0.478													2	4	---	---	---	---					
LOC100506834	100506834	broad.mit.edu	37	9	89592990	89592990	+	RNA	DEL	G	G	-			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr9:89592990delG	ENST00000415801.1	+	0	428					NR_049794.1																						AACACAACTTGTTCATCAGCC	0.453													2	4	---	---	---	---					
RP11-308N19.1	0	broad.mit.edu	37	9	109111255	109111255	+	RNA	DEL	G	G	-			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr9:109111255delG	ENST00000435485.1	+	0	171																											atgcctttgtggactcatagc	0.418													2	4	---	---	---	---					
RP11-18B16.2	0	broad.mit.edu	37	9	116415482	116415483	+	RNA	DEL	AG	AG	-			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr9:116415482_116415483delAG	ENST00000428292.1	+	0	273																											gaagagaaatagagagagagag	0.441													2	4	---	---	---	---					
RP11-672F9.1	0	broad.mit.edu	37	10	38560862	38560863	+	RNA	DEL	AA	AA	-	rs60895253		TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr10:38560862_38560863delAA	ENST00000450980.1	+	0	144																											cgaaaaaaagaaaaaaaaaaaa	0.485													4	4	---	---	---	---					
RP11-672F9.1	0	broad.mit.edu	37	10	38584590	38584592	+	RNA	DEL	TGT	TGT	-			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr10:38584590_38584592delTGT	ENST00000450980.1	+	0	144																											CTGAAACTTATGTTGTCCATTGC	0.394													3	4	---	---	---	---					
TMEM72-AS1	220980	broad.mit.edu	37	10	45399946	45399947	+	RNA	INS	-	-	A	rs147150139		TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr10:45399946_45399947insA	ENST00000450287.2	-	0	244				RP11-285G1.2_ENST00000436877.2_RNA	NR_033842.1																						gactccatcttaaaaaaaaaaa	0.520													2	4	---	---	---	---					
ANTXRLP1	100996567	broad.mit.edu	37	10	47628695	47628695	+	RNA	DEL	A	A	-			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr10:47628695delA	ENST00000454837.1	-	0	291					NR_103827.1																						ctgaaatgataacaatttttt	0.373													2	4	---	---	---	---					
RP11-556E13.1	0	broad.mit.edu	37	10	54411862	54411862	+	RNA	DEL	T	T	-			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr10:54411862delT	ENST00000443523.1	-	0	100																											TTGTTTGGGATTTTTTTTTTT	0.313													3	4	---	---	---	---					
RP11-170M17.1	0	broad.mit.edu	37	10	65446695	65446696	+	RNA	INS	-	-	T	rs139899281	by1000genomes	TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr10:65446695_65446696insT	ENST00000444770.1	+	0	494																											CAATAAGCTGATTTTTTTTTGT	0.361													4	2	---	---	---	---					
DHCR7	1717	broad.mit.edu	37	11	71160015	71160016	+	RNA	INS	-	-	G			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr11:71160015_71160016insG	ENST00000529369.1	+	0	212																											cctgcttattaggggggcacac	0.634													2	4	---	---	---	---					
RP11-867G2.8	0	broad.mit.edu	37	11	94435895	94435895	+	RNA	DEL	C	C	-			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr11:94435895delC	ENST00000536540.1	-	0	52				RP11-867G2.8_ENST00000537874.1_RNA																							aggggaggagccacacacttt	0.483													2	4	---	---	---	---					
RP11-563P16.1	0	broad.mit.edu	37	11	103547033	103547034	+	RNA	INS	-	-	C			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr11:103547033_103547034insC	ENST00000533459.1	-	0	381																											aagttactccaccccctaagga	0.406													2	4	---	---	---	---					
LINC00900	283143	broad.mit.edu	37	11	115627844	115627844	+	RNA	DEL	C	C	-			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr11:115627844delC	ENST00000499809.1	-	0	443				AP000797.3_ENST00000539305.1_lincRNA	NR_034148.1																						TTCCATTTTTCCCCTGTGTCT	0.433													2	4	---	---	---	---					
RP11-820L6.1	0	broad.mit.edu	37	11	122160021	122160021	+	RNA	DEL	T	T	-			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr11:122160021delT	ENST00000527474.1	-	0	898																											GTGGTACTCAttttttttgtt	0.463													2	4	---	---	---	---					
RP11-264E20.1	0	broad.mit.edu	37	11	128488223	128488223	+	RNA	DEL	A	A	-	rs74402575		TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr11:128488223delA	ENST00000531784.1	-	0	173																											GCTCAACATGAAAAAAAAAAA	0.458													3	4	---	---	---	---					
LINC00937	389634	broad.mit.edu	37	12	8476433	8476433	+	RNA	DEL	T	T	-	rs57375584		TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr12:8476433delT	ENST00000544461.1	-	0	1081				RP11-113C12.4_ENST00000537764.1_RNA|RP11-90D4.3_ENST00000535746.1_lincRNA																							tttataacagttttttttttt	0.423													3	3	---	---	---	---					
LINC00937	389634	broad.mit.edu	37	12	8514372	8514373	+	RNA	INS	-	-	T	rs112127899	by1000genomes	TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr12:8514372_8514373insT	ENST00000544461.1	-	0	1081				RP11-113C12.4_ENST00000537764.1_RNA																							AACACAAAACATTTCATGAGTA	0.386													5	2	---	---	---	---					
RP11-630C16.2	0	broad.mit.edu	37	12	42226576	42226577	+	RNA	INS	-	-	C			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr12:42226576_42226577insC	ENST00000550874.1	-	0	471																											TTCCAGTACCTCCCCCTCACTG	0.485													2	4	---	---	---	---					
PLEKHA8P1	51054	broad.mit.edu	37	12	45607955	45607956	+	RNA	INS	-	-	A			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr12:45607955_45607956insA	ENST00000256692.5	-	0	67					NR_037144.1															breast(1)|endometrium(2)|kidney(2)|large_intestine(8)|lung(10)|pancreas(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	26						AAAGTGATCTGAAAAAAAAATG	0.391													2	4	---	---	---	---					
RP11-493L12.5	0	broad.mit.edu	37	12	47756194	47756194	+	RNA	DEL	T	T	-			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr12:47756194delT	ENST00000550019.1	+	0	129																											ggCCTCAGCATTTTTTTTTTT	0.398													3	3	---	---	---	---					
RP11-110A12.2	0	broad.mit.edu	37	12	55975440	55975440	+	RNA	DEL	C	C	-			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr12:55975440delC	ENST00000556750.1	-	0	57				RP11-110A12.2_ENST00000555138.1_RNA																							ctccagtaggccccagtgtat	0.433													2	4	---	---	---	---					
RP11-123O10.4	0	broad.mit.edu	37	12	67390149	67390149	+	RNA	DEL	A	A	-	rs11297691		TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr12:67390149delA	ENST00000535721.1	-	0	113																											TTTCACAATTAAAAAAAAAAA	0.363													3	4	---	---	---	---					
RP11-754N21.1	0	broad.mit.edu	37	12	78847975	78847976	+	RNA	DEL	AA	AA	-			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr12:78847975_78847976delAA	ENST00000548963.1	+	0	245				RP11-171L9.1_ENST00000546865.1_lincRNA																							GTAGAAACTTAAAAAATGAAAG	0.312													2	4	---	---	---	---					
RP11-541G9.1	0	broad.mit.edu	37	12	97450388	97450388	+	RNA	DEL	T	T	-			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr12:97450388delT	ENST00000552238.1	+	0	39																											atgtttaatcttttttttttt	0.353													3	4	---	---	---	---					
RP11-148B3.2	0	broad.mit.edu	37	12	116823081	116823082	+	RNA	INS	-	-	T	rs112282059		TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr12:116823081_116823082insT	ENST00000548506.1	+	0	403																											ttattattATCTTTTTTTTTTT	0.411													2	4	---	---	---	---					
LINC00539	100652865	broad.mit.edu	37	13	21909560	21909560	+	RNA	DEL	A	A	-			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr13:21909560delA	ENST00000434601.2	-	0	388					NR_103840.1																						actccgtctcaaaaaaaaaaa	0.493													2	4	---	---	---	---					
POSTN	10631	broad.mit.edu	37	13	38172778	38172778	+	Frame_Shift_Del	DEL	A	A	-			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr13:38172778delA	ENST00000379747.4	-	1	203	c.86delT	c.(85-87)tgfs	p.L29fs	POSTN_ENST00000379742.4_Frame_Shift_Del_p.L29fs|POSTN_ENST00000541481.1_Frame_Shift_Del_p.L29fs|POSTN_ENST00000379743.4_Frame_Shift_Del_p.L29fs|POSTN_ENST00000379749.4_Frame_Shift_Del_p.L29fs|POSTN_ENST00000541179.1_Frame_Shift_Del_p.L29fs	NM_006475.2	NP_006466.2	Q15063	POSTN_HUMAN	periostin, osteoblast specific factor	29					cell adhesion|skeletal system development	proteinaceous extracellular matrix	heparin binding			cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(16)|lung(22)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	59		Lung NSC(96;2.09e-05)|Prostate(109;0.0513)|Breast(139;0.0538)|Lung SC(185;0.0743)		all cancers(112;2.48e-08)|Epithelial(112;2.78e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000853)|BRCA - Breast invasive adenocarcinoma(63;0.013)|GBM - Glioblastoma multiforme(144;0.0154)		ACTATGAGCCAAGATCTTGTC	0.393													24	63	---	---	---	---					
LINC00598	646982	broad.mit.edu	37	13	41033203	41033218	+	RNA	DEL	AGGGAGAGAGGGAGGG	AGGGAGAGAGGGAGGG	-	rs11268012		TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr13:41033203_41033218delAGGGAGAGAGGGAGGG	ENST00000400430.2	-	0	492																											GAAAAAAGAAagggagagagggagggagggagagag	0.444													4	3	---	---	---	---					
RP11-321C24.1	0	broad.mit.edu	37	13	45656443	45656443	+	RNA	DEL	A	A	-			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr13:45656443delA	ENST00000437748.2	-	0	88																											actccgtttcaaaaaaaaaaa	0.517													2	4	---	---	---	---					
LINC00348	100885781	broad.mit.edu	37	13	71740516	71740516	+	RNA	DEL	A	A	-	rs75210819	by1000genomes	TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr13:71740516delA	ENST00000428761.1	+	0	159					NR_047699.1																						GTTGTACATCAAAAGCCTTAG	0.368													2	4	---	---	---	---					
LINC00351	100874137	broad.mit.edu	37	13	85992874	85992874	+	RNA	DEL	T	T	-			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr13:85992874delT	ENST00000424926.2	+	0	495					NR_046989.1																						GTACAACACATTTATGCTTCA	0.303													2	4	---	---	---	---					
LINC00559	100874187	broad.mit.edu	37	13	90766650	90766651	+	RNA	INS	-	-	A	rs150414814	by1000genomes	TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr13:90766650_90766651insA	ENST00000569476.1	-	0	947					NR_047489.1																						TGGTCAGCCACAAAAAAGCTCC	0.396													3	4	---	---	---	---					
LINC00559	100874187	broad.mit.edu	37	13	90768909	90768917	+	RNA	DEL	TGTAGTATC	TGTAGTATC	-	rs67939991		TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr13:90768909_90768917delTGTAGTATC	ENST00000569476.1	-	0	947					NR_047489.1																						CCTAATCATTTGTAGTATCTGTAGTATCT	0.378													3	4	---	---	---	---					
NALCN-AS1	100885778	broad.mit.edu	37	13	101586704	101586705	+	RNA	INS	-	-	G	rs34877626	by1000genomes	TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr13:101586704_101586705insG	ENST00000457843.1	+	0	141					NR_047687.1																						AAAAAAAACAAGGGGGGGGGTA	0.356													5	2	---	---	---	---					
CTD-2058B24.2	0	broad.mit.edu	37	14	38644028	38644028	+	RNA	DEL	C	C	-	rs35450824		TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr14:38644028delC	ENST00000554687.1	-	0	140																											aaactacagtcccttgattct	0.413													3	4	---	---	---	---					
RP11-313C4.1	0	broad.mit.edu	37	14	42732985	42732986	+	RNA	INS	-	-	T			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr14:42732985_42732986insT	ENST00000555362.1	-	0	95																											gttttctagtgtttttttgata	0.312													2	4	---	---	---	---					
CTD-2307P3.1	0	broad.mit.edu	37	14	43055562	43055562	+	RNA	DEL	A	A	-			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr14:43055562delA	ENST00000557251.1	+	0	166																											ACAAGAAAATAAATGCAATTT	0.378													2	4	---	---	---	---					
RP11-305B6.3	0	broad.mit.edu	37	14	44519362	44519363	+	RNA	INS	-	-	A	rs147693497	by1000genomes	TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr14:44519362_44519363insA	ENST00000553827.1	-	0	69																											TCTAGAGAAAGAAAAAAAAACT	0.322													4	2	---	---	---	---					
RP11-857B24.1	0	broad.mit.edu	37	14	45359444	45359444	+	RNA	DEL	A	A	-			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr14:45359444delA	ENST00000554389.1	-	0	66																											ctcctcctataacctgttgat	0.443													2	4	---	---	---	---					
RP11-1033H12.1	0	broad.mit.edu	37	14	52592541	52592542	+	RNA	INS	-	-	T	rs146187536	by1000genomes	TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr14:52592541_52592542insT	ENST00000555852.1	-	0	45																											ACCAAACAACACCAAATTCATG	0.391													5	1	---	---	---	---					
KTN1-AS1	100129075	broad.mit.edu	37	14	55974148	55974149	+	RNA	INS	-	-	A	rs142670091	by1000genomes	TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr14:55974148_55974149insA	ENST00000554558.1	-	0	364																											TGAGTCTATGGATTGAGAAGTC	0.406													2	4	---	---	---	---					
OTX2-AS1	100309464	broad.mit.edu	37	14	57367477	57367500	+	RNA	DEL	CACACACACACACACACACACACG	CACACACACACACACACACACACG	-	rs58476426	by1000genomes	TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr14:57367477_57367500delCACACACACACACACACACACACG	ENST00000534909.2	+	0	474				OTX2-AS1_ENST00000554428.1_RNA|OTX2-AS1_ENST00000554725.1_RNA|OTX2-AS1_ENST00000554358.1_RNA	NR_029385.1																						cacacacaaacacacacacacacacacacacacgcacacacaca	0.455													4	5	---	---	---	---					
RP11-361H10.3	0	broad.mit.edu	37	14	76724413	76724413	+	RNA	DEL	C	C	-	rs144358285		TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr14:76724413delC	ENST00000554225.1	+	0	245																											aagatggctgccacagccctt	0.517													2	4	---	---	---	---					
RP11-114N19.3	0	broad.mit.edu	37	14	81622911	81622911	+	RNA	DEL	T	T	-	rs79933213		TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr14:81622911delT	ENST00000557775.1	-	0	495																											attgcctctcttttttttttt	0.443													2	4	---	---	---	---					
HERC2P3	283755	broad.mit.edu	37	15	20614996	20614999	+	RNA	DEL	TTTG	TTTG	-			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr15:20614996_20614999delTTTG	ENST00000428453.1	-	0	4041																				central_nervous_system(1)|endometrium(11)|kidney(2)|large_intestine(1)|lung(14)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	35						CCCTCACTTATTTGTTTGTTTAtt	0.392													5	6	---	---	---	---					
LOC100128714	100128714	broad.mit.edu	37	15	26155665	26155666	+	RNA	INS	-	-	A	rs11451447	by1000genomes	TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr15:26155665_26155666insA	ENST00000383019.2	+	0	207					NR_040082.1																						gactcagactcaaaaaaacaaa	0.475													5	2	---	---	---	---					
RP11-463I20.3	0	broad.mit.edu	37	15	35294232	35294235	+	RNA	DEL	GAAG	GAAG	-	rs34700807		TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr15:35294232_35294235delGAAG	ENST00000560140.1	+	0	377																											aggaatgcatgaaggaaggaagga	0.441													4	9	---	---	---	---					
RP11-507B12.2	0	broad.mit.edu	37	15	61917173	61917173	+	RNA	DEL	T	T	-			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr15:61917173delT	ENST00000559783.1	-	0	35																											GAGGAATAAGTTAGGCTTTGT	0.433													2	4	---	---	---	---					
RP11-798K3.2	0	broad.mit.edu	37	15	67299332	67299333	+	RNA	DEL	AC	AC	-	rs59414627		TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr15:67299332_67299333delAC	ENST00000558071.1	-	0	114																											AGAGAAGAAGACACAGATTTAG	0.505													4	2	---	---	---	---					
RP11-382A20.4	0	broad.mit.edu	37	15	84059113	84059113	+	RNA	DEL	A	A	-			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr15:84059113delA	ENST00000565495.1	+	0	264																											CTTCTTGAAGAAAAAAAAAAA	0.403													2	4	---	---	---	---					
LINC00928	283761	broad.mit.edu	37	15	90057187	90057188	+	RNA	DEL	TA	TA	-			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr15:90057187_90057188delTA	ENST00000561201.1	-	0	490					NR_027075.1																						GAATAGAATGTATGTTttcttg	0.450													5	2	---	---	---	---					
RP11-152L20.3	0	broad.mit.edu	37	15	92854018	92854018	+	RNA	DEL	A	A	-			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr15:92854018delA	ENST00000561674.1	-	0	185																											ctccatctccaaaaaaaaaaa	0.393													3	4	---	---	---	---					
LINC01197	400456	broad.mit.edu	37	15	95867414	95867417	+	RNA	DEL	ACAG	ACAG	-			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr15:95867414_95867417delACAG	ENST00000508732.2	-	0	271					NR_034095.1																						TCTTTCTCAAACAGACAGAGCATG	0.324													6	5	---	---	---	---					
CTD-2544M6.1	0	broad.mit.edu	37	15	98812319	98812320	+	RNA	INS	-	-	C			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr15:98812319_98812320insC	ENST00000560360.1	-	0	201																											GGCAGCCCTGGCCCACGGAGCA	0.520													2	4	---	---	---	---					
RP11-420N3.2	0	broad.mit.edu	37	16	5323766	5323766	+	RNA	DEL	A	A	-	rs146442154	by1000genomes	TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr16:5323766delA	ENST00000569895.1	+	0	304																											CAGATGGCCCAAAAAAGGCTG	0.502													2	4	---	---	---	---					
RP11-420N3.2	0	broad.mit.edu	37	16	5612503	5612504	+	RNA	INS	-	-	G	rs148489785	by1000genomes	TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr16:5612503_5612504insG	ENST00000569895.1	+	0	343																											GAGGAGAAGAAGGGGGAGGACC	0.550													8	8	---	---	---	---					
RP11-420N3.2	0	broad.mit.edu	37	16	5725220	5725221	+	RNA	DEL	CA	CA	-			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr16:5725220_5725221delCA	ENST00000569895.1	+	0	403																											TGTACTcacgcacacacacaca	0.436													4	5	---	---	---	---					
U91319.1	0	broad.mit.edu	37	16	13421689	13421689	+	RNA	DEL	T	T	-			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr16:13421689delT	ENST00000571619.1	+	0	178																											aatttttgtatttttttagta	0.537													2	4	---	---	---	---					
CTA-481E9.3	0	broad.mit.edu	37	16	18191351	18191352	+	RNA	DEL	TG	TG	-			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr16:18191351_18191352delTG	ENST00000563866.1	-	0	48				CTA-481E9.4_ENST00000567304.1_lincRNA																							AGCATTCCTTtgtgtgtgtgtg	0.371													3	5	---	---	---	---					
TNRC6A	27327	broad.mit.edu	37	16	24804889	24804890	+	Frame_Shift_Ins	INS	-	-	G	rs139796934		TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr16:24804889_24804890insG	ENST00000395799.3	+	7	3400_3401	c.3271_3272insG	c.(3271-3273)gggfs	p.G1091fs	TNRC6A_ENST00000315183.7_Frame_Shift_Ins_p.G1091fs	NM_014494.2	NP_055309.2	Q8NDV7	TNR6A_HUMAN	trinucleotide repeat containing 6A	1091	Sufficient for interaction with EIF2C1 and EIF2C4.|Sufficient for interaction with EIF2C2.				negative regulation of translation involved in gene silencing by miRNA	cytoplasmic mRNA processing body|micro-ribonucleoprotein complex	nucleotide binding|RNA binding			breast(1)|cervix(1)|endometrium(13)|kidney(5)|large_intestine(13)|liver(1)|lung(20)|ovary(3)|skin(2)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	64				GBM - Glioblastoma multiforme(48;0.0394)		TGGTCCCAGCTGGGGGGAACCC	0.550													7	157	---	---	---	---					
SNX29P2	440352	broad.mit.edu	37	16	29439508	29439509	+	RNA	INS	-	-	C			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr16:29439508_29439509insC	ENST00000398878.3	+	0	5991																											ATGGGATTCTGCCCCCCCAAAA	0.317													2	4	---	---	---	---					
HERC2P4	100289574	broad.mit.edu	37	16	32123215	32123215	+	RNA	DEL	G	G	-			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr16:32123215delG	ENST00000564145.1	-	0	456																											tattctagaaGGATAAATTAT	0.343													4	8	---	---	---	---					
LOC102723841	102723841	broad.mit.edu	37	16	33366282	33366283	+	RNA	INS	-	-	G			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr16:33366282_33366283insG	ENST00000568520.1	-	0	84																											aaataaaaaTCGGGGGGGAGAA	0.441													2	4	---	---	---	---					
CHD9	80205	broad.mit.edu	37	16	53243421	53243450	+	In_Frame_Del	DEL	TCTGGGACATATACTAAGTTGCAGAATACC	TCTGGGACATATACTAAGTTGCAGAATACC	-			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr16:53243421_53243450delTCTGGGACATATACTAAGTTGCAGAATACC	ENST00000566029.1	+	3	1689_1718	c.1480_1509delTCTGGGACATATACTAAGTTGCAGAATACC	c.(1480-1509)del	p.SGTYTKLQNT494del	CHD9_ENST00000564845.1_In_Frame_Del_p.SGTYTKLQNT494del|CHD9_ENST00000447540.1_In_Frame_Del_p.SGTYTKLQNT494del|CHD9_ENST00000398510.3_In_Frame_Del_p.SGTYTKLQNT494del			Q3L8U1	CHD9_HUMAN	chromodomain helicase DNA binding protein 9	494					cellular lipid metabolic process|chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleoplasm	ATP binding|DNA binding|helicase activity|protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(5)|kidney(6)|large_intestine(21)|lung(32)|ovary(2)|prostate(2)|skin(2)|stomach(1)|urinary_tract(1)	78		all_cancers(37;0.0212)				GAGCGATGGTTCTGGGACATATACTAAGTTGCAGAATACCCAGGTGAGGG	0.365													10	30	---	---	---	---					
RP11-459F6.3	0	broad.mit.edu	37	16	58165598	58165605	+	RNA	DEL	CTCTCTTC	CTCTCTTC	-	rs71155241		TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr16:58165598_58165605delCTCTCTTC	ENST00000569580.1	+	0	135																											TTTTTCttttctctcttctttttttttt	0.399													2	4	---	---	---	---					
RP11-410D17.2	0	broad.mit.edu	37	16	59125395	59125395	+	RNA	DEL	G	G	-			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr16:59125395delG	ENST00000500117.1	+	0	749																											TTCACAGGGTGGCAAGCAGGC	0.393													6	7	---	---	---	---					
LINC00922	283867	broad.mit.edu	37	16	65462513	65462514	+	RNA	INS	-	-	T	rs77803779	by1000genomes	TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr16:65462513_65462514insT	ENST00000569736.1	-	0	217				RP11-256I9.3_ENST00000562656.1_lincRNA	NR_027755.1																						gacaacccatattttttttttc	0.322													2	4	---	---	---	---					
RP11-77K12.5	0	broad.mit.edu	37	16	75539673	75539673	+	RNA	DEL	T	T	-			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr16:75539673delT	ENST00000571737.1	-	0	78																											TGTACTGGTGTTTTTTTTTCT	0.388													2	4	---	---	---	---					
CTD-2336H13.2	0	broad.mit.edu	37	16	76880327	76880328	+	RNA	DEL	CA	CA	-	rs148468241	by1000genomes	TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr16:76880327_76880328delCA	ENST00000567777.1	+	0	138																											cacacacatgcacacacacaca	0.401													2	4	---	---	---	---					
CDYL2	124359	broad.mit.edu	37	16	80633635	80633635	+	RNA	DEL	A	A	-			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr16:80633635delA	ENST00000570137.1	-	0	2781																											TGCCAGGGTCAGGAGCAGGAA	0.468													2	4	---	---	---	---					
KIF1C	10749	broad.mit.edu	37	17	4925397	4925398	+	Frame_Shift_Ins	INS	-	-	G			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr17:4925397_4925398insG	ENST00000320785.5	+	22	2378_2379	c.2021_2022insG	c.(2020-2022)tgafs	p.*674fs	KIF1C_ENST00000573815.1_3'UTR	NM_006612.5	NP_006603.2	O43896	KIF1C_HUMAN	kinesin family member 1C	674					microtubule-based movement|retrograde vesicle-mediated transport, Golgi to ER	endoplasmic reticulum|Golgi apparatus|microtubule	ATP binding|microtubule motor activity			NS(2)|breast(4)|endometrium(4)|kidney(2)|large_intestine(8)|lung(6)|skin(1)|urinary_tract(3)	30						TATGCAGACTCGGACAGCGGGG	0.574													9	210	---	---	---	---					
MYHAS	100128560	broad.mit.edu	37	17	10489368	10489369	+	RNA	INS	-	-	T	rs149279541		TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr17:10489368_10489369insT	ENST00000587182.1	+	0	231				CTC-297N7.7_ENST00000579914.1_RNA																							CTTTTTAAGACttttttttttt	0.431													3	3	---	---	---	---					
COX10-AS1	100874058	broad.mit.edu	37	17	13742394	13742394	+	RNA	DEL	A	A	-	rs71352419		TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr17:13742394delA	ENST00000577798.2	-	0	373				COX10-AS1_ENST00000602743.1_RNA|COX10-AS1_ENST00000582752.2_RNA																							actccatctcaaaaaaaaaaa	0.483													3	4	---	---	---	---					
SMURF2P1	0	broad.mit.edu	37	17	28973188	28973188	+	RNA	DEL	A	A	-			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr17:28973188delA	ENST00000578265.1	+	0	287																											TGAGGGGAGGAAAACACCCCG	0.532													2	4	---	---	---	---					
RP11-445F12.1	0	broad.mit.edu	37	17	35256461	35256461	+	RNA	DEL	A	A	-			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr17:35256461delA	ENST00000528383.1	-	0	98																											gagcaagaccaaaaaaaaaaa	0.438													2	4	---	---	---	---					
YWHAEP7	284100	broad.mit.edu	37	17	36241505	36241505	+	RNA	DEL	G	G	-			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr17:36241505delG	ENST00000590732.1	-	0	108					NR_024178.1																						TAGATAACATGGTTAAAAAGG	0.373													2	4	---	---	---	---					
MAP3K14	9020	broad.mit.edu	37	17	43371190	43371191	+	RNA	DEL	CA	CA	-			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr17:43371190_43371191delCA	ENST00000344686.2	-	0	89							Q99558	M3K14_HUMAN	mitogen-activated protein kinase kinase kinase 14						cellular response to mechanical stimulus|I-kappaB kinase/NF-kappaB cascade|immune response|positive regulation of I-kappaB kinase/NF-kappaB cascade|T cell costimulation	cytosol	ATP binding|MAP kinase kinase kinase activity|NF-kappaB-inducing kinase activity|protein binding			breast(3)|central_nervous_system(4)|cervix(2)|endometrium(3)|kidney(1)|large_intestine(4)|lung(5)|ovary(2)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	27						gacacacatgcacacacacaca	0.515													2	4	---	---	---	---					
TOB1-AS1	400604	broad.mit.edu	37	17	48978093	48978094	+	RNA	INS	-	-	G			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr17:48978093_48978094insG	ENST00000514358.1	+	0	161				TOB1-AS1_ENST00000523470.1_RNA																							CTGGGAGGGGAGGGGGGGGTTC	0.604													2	4	---	---	---	---					
CTC-264K15.6	0	broad.mit.edu	37	17	62050435	62050436	+	RNA	INS	-	-	C	rs35134985		TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr17:62050435_62050436insC	ENST00000577329.1	-	0	345_346																											ATCACCCCTGGCCCCCCCACCA	0.639													2	4	---	---	---	---					
LOC102723505	102723505	broad.mit.edu	37	17	70018181	70018183	+	RNA	DEL	AAA	AAA	-	rs60415916		TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr17:70018181_70018183delAAA	ENST00000430908.2	-	0	217																											CTTTGGAAGGAAAAAAAAAAAAA	0.305													2	4	---	---	---	---					
RP11-101O21.1	0	broad.mit.edu	37	17	72131269	72131269	+	RNA	DEL	C	C	-			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr17:72131269delC	ENST00000584003.1	-	0	163																											ttccccttctcctgtacccct	0.512													2	4	---	---	---	---					
RP11-161I6.2	0	broad.mit.edu	37	18	2110435	2110435	+	RNA	DEL	A	A	-	rs76061247		TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr18:2110435delA	ENST00000579097.1	-	0	310																											accctgtctcaaaaaaaaaaa	0.512													4	6	---	---	---	---					
RP11-703M24.5	0	broad.mit.edu	37	18	2821611	2821611	+	RNA	DEL	A	A	-			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr18:2821611delA	ENST00000583546.1	-	0	308																											ccagcaccgtaactcctttct	0.512													2	4	---	---	---	---					
RP11-449D8.5	0	broad.mit.edu	37	18	22420632	22420633	+	RNA	DEL	TG	TG	-			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr18:22420632_22420633delTG	ENST00000582650.1	+	0	235																											GCCAtgtgtatgtgtgtgtgtg	0.436													3	5	---	---	---	---					
RP11-449D8.5	0	broad.mit.edu	37	18	22442084	22442084	+	RNA	DEL	T	T	-			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr18:22442084delT	ENST00000582650.1	+	0	235																											TATTTTATGATTTTTAAATGT	0.353													2	4	---	---	---	---					
LINC01532	100505835	broad.mit.edu	37	19	29501138	29501139	+	RNA	INS	-	-	ACAT	rs62111174		TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr19:29501138_29501139insACAT	ENST00000591143.1	+	0	287					NR_040036.1																						tacacatacacacgcccaccta	0.446													5	3	---	---	---	---					
AC007796.1	0	broad.mit.edu	37	19	31871306	31871306	+	RNA	DEL	G	G	-			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr19:31871306delG	ENST00000585336.1	+	0	251																											acaacaccttggattttctct	0.502													2	4	---	---	---	---					
CEACAM20	125931	broad.mit.edu	37	19	45032189	45032192	+	RNA	DEL	TTTC	TTTC	-	rs112438515	by1000genomes	TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr19:45032189_45032192delTTTC	ENST00000454753.1	-	0	331							Q6UY09	CEA20_HUMAN	carcinoembryonic antigen-related cell adhesion molecule 20							integral to membrane				central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(8)|prostate(1)	15		Prostate(69;0.0352)				ctttctttcttttctttctttctt	0.392													3	4	---	---	---	---					
SNAP25-AS1	100131208	broad.mit.edu	37	20	10292713	10292713	+	RNA	DEL	T	T	-	rs34912469		TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr20:10292713delT	ENST00000421143.2	-	0	5				SNAP25-AS1_ENST00000453544.1_RNA																							ttcctacttgttttttttctg	0.398													3	3	---	---	---	---					
RP4-610C12.1	0	broad.mit.edu	37	20	29582648	29582649	+	RNA	INS	-	-	A	rs113003528		TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr20:29582648_29582649insA	ENST00000432067.1	-	0	288																											ACCAACCAAAGAATGTTTGCTC	0.446													4	7	---	---	---	---					
RP4-610C12.1	0	broad.mit.edu	37	20	29584135	29584136	+	RNA	INS	-	-	A	rs73621631		TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr20:29584135_29584136insA	ENST00000432067.1	-	0	288																											gaccctatttcaaaaaaaTTAT	0.431													7	31	---	---	---	---					
RP4-610C12.1	0	broad.mit.edu	37	20	29591671	29591673	+	RNA	DEL	AGA	AGA	-	rs73620377		TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr20:29591671_29591673delAGA	ENST00000432067.1	-	0	152																											CAAAAGCAGCAGAAGTTAGCTTT	0.424													4	5	---	---	---	---					
MIR646HG	284757	broad.mit.edu	37	20	58785597	58785598	+	RNA	DEL	CA	CA	-			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr20:58785597_58785598delCA	ENST00000432910.1	+	0	332					NR_046099.1																						TGGTAAATTTCACACAGGCTTC	0.381													2	4	---	---	---	---					
BAGE2	85319	broad.mit.edu	37	21	11033264	11033265	+	RNA	INS	-	-	A	rs143646950	by1000genomes	TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr21:11033264_11033265insA	ENST00000470054.1	-	0	1476									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		TAAAAATTACTAAAAAATCTAT	0.257													4	5	---	---	---	---					
BAGE2	85319	broad.mit.edu	37	21	11045506	11045507	+	RNA	INS	-	-	A	rs144248158		TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr21:11045506_11045507insA	ENST00000470054.1	-	0	774									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		TAAAAGAAGAGAAAAATAGAAA	0.277													4	6	---	---	---	---					
AP000233.4	0	broad.mit.edu	37	21	26658887	26658887	+	RNA	DEL	A	A	-			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr21:26658887delA	ENST00000409758.1	-	0	89																											taatttggccaaggaacactt	0.388													2	4	---	---	---	---					
LOC101927973	101927973	broad.mit.edu	37	21	29522257	29522264	+	RNA	DEL	GTGTGTGT	GTGTGTGT	-	rs148057472	by1000genomes	TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr21:29522257_29522264delGTGTGTGT	ENST00000453420.1	-	0	705																											GCGCGCGCGCgtgtgtgtgtgtgtgtgt	0.519													2	4	---	---	---	---					
CRYBB2P1	1416	broad.mit.edu	37	22	25898379	25898380	+	RNA	INS	-	-	G			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr22:25898379_25898380insG	ENST00000354451.2	+	0	366																											caaggatatttggggggtgatg	0.376													3	4	---	---	---	---					
CRYBB2P1	1416	broad.mit.edu	37	22	25901640	25901640	+	RNA	DEL	T	T	-			TCGA-17-Z000-01A-01W-0746-08	TCGA-17-Z000-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ba9d9630-fc6c-4ffb-8464-c1a2ddec6579	11b8842a-0156-4af7-a5e5-ebc07aef4a9f	g.chr22:25901640delT	ENST00000354451.2	+	0	366																											ctggccAAGATTTTTTTTTTT	0.463													4	4	---	---	---	---