Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	ACHILLES_Top_Genes	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
PLCH2	9651	broad.mit.edu	37	1	2429996	2429996	+	Silent	SNP	C	C	A			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr1:2429996C>A	uc001aji.1	+	17	2533	c.2259C>A	c.(2257-2259)CCC>CCA	p.P753P	PLCH2_uc010nyz.1_Silent_p.P541P|PLCH2_uc009vle.1_Silent_p.P505P|PLCH2_uc001ajj.1_Silent_p.P541P|PLCH2_uc001ajk.1_Silent_p.P541P|PLCH2_uc001ajl.1_5'Flank	NM_014638	NP_055453	O75038	PLCH2_HUMAN	phospholipase C, eta 2	753	C2.				intracellular signal transduction|lipid catabolic process	cytoplasm|plasma membrane	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			central_nervous_system(3)|ovary(1)|skin(1)	5	all_cancers(77;0.000161)|all_epithelial(69;5.98e-05)|all_lung(157;0.016)|Lung NSC(156;0.0376)|Ovarian(185;0.0634)	all_epithelial(116;7.32e-16)|all_lung(118;1.15e-06)|Lung NSC(185;6.26e-05)|Renal(390;0.00571)|Breast(487;0.00832)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Medulloblastoma(700;0.151)|Lung SC(97;0.217)		Epithelial(90;1.44e-37)|OV - Ovarian serous cystadenocarcinoma(86;6.78e-23)|GBM - Glioblastoma multiforme(42;2.8e-08)|Colorectal(212;4.19e-05)|COAD - Colon adenocarcinoma(227;0.000195)|Kidney(185;0.00034)|BRCA - Breast invasive adenocarcinoma(365;0.00443)|KIRC - Kidney renal clear cell carcinoma(229;0.00548)|STAD - Stomach adenocarcinoma(132;0.00644)|Lung(427;0.2)		ACCCCCTGCCCGGGCAGCTCA	0.687			NA											5	13					1.23904e-05	1.47252e-05	0.000602	1	0
KLHDC7A	127707	broad.mit.edu	37	1	18809454	18809454	+	Missense_Mutation	SNP	G	G	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr1:18809454G>T	uc001bax.2	+	1	2031	c.1979G>T	c.(1978-1980)GGC>GTC	p.G660V	KLHDC7A_uc009vpg.2_Missense_Mutation_p.G442V	NM_152375	NP_689588	Q5VTJ3	KLD7A_HUMAN	kelch domain containing 7A	660	Kelch 5.					integral to membrane				ovary(2)|upper_aerodigestive_tract(1)	3		Colorectal(325;3.46e-05)|all_lung(284;0.000152)|Lung NSC(340;0.000185)|Breast(348;0.00046)|Renal(390;0.000518)|Ovarian(437;0.0014)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00462)|BRCA - Breast invasive adenocarcinoma(304;1.41e-05)|Kidney(64;0.00017)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)		TGGTGGGCCGGCCCCACCGGG	0.677			NA											8	46					1.06961e-07	1.44047e-07	0.00308	1	0
EPHA10	284656	broad.mit.edu	37	1	38227387	38227387	+	Silent	SNP	G	G	T	rs143929786		TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr1:38227387G>T	uc009vvi.2	-	3	626	c.540C>A	c.(538-540)ATC>ATA	p.I180I	EPHA10_uc001cbw.3_Silent_p.I180I	NM_001099439	NP_001092909	Q5JZY3	EPHAA_HUMAN	EPH receptor A10 isofom 3	180	Extracellular (Potential).					extracellular region|integral to membrane|integral to plasma membrane	ATP binding|ephrin receptor activity|protein binding|transmembrane-ephrin receptor activity			breast(4)|stomach(3)|lung(1)	8	Acute lymphoblastic leukemia(166;0.074)|all_hematologic(146;0.197)	Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				TGAGCGGTCCGATCTCGCGCA	0.662			NA											14	70					3.27435e-08	4.48551e-08	0.00245	1	0
ERI3	79033	broad.mit.edu	37	1	44750540	44750540	+	Silent	SNP	C	C	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr1:44750540C>T	uc001clt.2	-	7	1039	c.798G>A	c.(796-798)GCG>GCA	p.A266A	ERI3_uc010okv.1_Silent_p.A89A|ERI3_uc009vxg.2_Silent_p.A266A|ERI3_uc010okw.1_Silent_p.A188A|ERI3_uc001clu.2_Silent_p.A188A	NM_024066	NP_076971	O43414	ERI3_HUMAN	prion protein interacting protein	266	Exonuclease.					intracellular	exonuclease activity|metal ion binding|nucleic acid binding			ovary(2)|large_intestine(1)	3						TGAAGTAATCCGCCACTGGCA	0.512			NA											10	52					0	0	0.006214	0	0
FAM159A	348378	broad.mit.edu	37	1	53122519	53122519	+	Missense_Mutation	SNP	T	T	G			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr1:53122519T>G	uc001cuf.2	+	3	480	c.380T>G	c.(379-381)GTG>GGG	p.V127G	FAM159A_uc001cug.1_Intron|FAM159A_uc001cuh.2_Intron	NM_001042693	NP_001036158	Q6UWV7	F159A_HUMAN	hypothetical protein LOC348378	127						integral to membrane					0						GCGGCAGAAGTGCCAAAAGTG	0.567			NA											24	109					0	0	0.014323	0	0
ACOT11	26027	broad.mit.edu	37	1	55060276	55060276	+	Silent	SNP	G	G	A			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr1:55060276G>A	uc001cxm.1	+	6	601	c.519G>A	c.(517-519)GAG>GAA	p.E173E	ACOT11_uc001cxj.1_Silent_p.E51E|ACOT11_uc001cxk.2_Silent_p.E139E|ACOT11_uc001cxl.1_Silent_p.E173E	NM_015547	NP_056362	Q8WXI4	ACO11_HUMAN	thioesterase, adipose associated isoform BFIT1	173					fatty acid metabolic process|intracellular signal transduction|response to cold		acyl-CoA thioesterase activity|carboxylesterase activity			central_nervous_system(1)	1						AGAAGATGGAGCACAGTGTGG	0.622	Ovarian(148;1440 1861 22015 32453 51933)		NA											7	34					0	0	0.00308	0	0
SFRS11	9295	broad.mit.edu	37	1	70715696	70715696	+	Missense_Mutation	SNP	A	A	G			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr1:70715696A>G	uc001des.2	+	11	1208	c.1084A>G	c.(1084-1086)AAA>GAA	p.K362E	SFRS11_uc001det.2_Missense_Mutation_p.K362E|SFRS11_uc001deu.2_Missense_Mutation_p.K369E|SFRS11_uc001dev.2_Missense_Mutation_p.K172E|SFRS11_uc001dew.2_Missense_Mutation_p.K302E	NM_004768	NP_004759	Q05519	SRS11_HUMAN	splicing factor, arginine/serine-rich 11	362					mRNA 3'-end processing|mRNA export from nucleus|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	nucleoplasm	nucleotide binding|protein binding|RNA binding				0						TCGGTCTCCTAAAAGAAAATT	0.368			NA											11	52					0	0	0.010729	0	0
CLCA4	22802	broad.mit.edu	37	1	87043639	87043639	+	Missense_Mutation	SNP	C	C	A			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr1:87043639C>A	uc009wcs.2	+	12	2050	c.2006C>A	c.(2005-2007)ACA>AAA	p.T669K	CLCA4_uc009wct.2_Missense_Mutation_p.T432K|CLCA4_uc009wcu.2_Missense_Mutation_p.T489K	NM_012128	NP_036260	Q14CN2	CLCA4_HUMAN	chloride channel accessory 4	669						apical plasma membrane|extracellular region|integral to plasma membrane	chloride channel activity			ovary(2)	2		Lung NSC(277;0.238)		all cancers(265;0.0202)|Epithelial(280;0.0404)		ACAGCATATACAGAAAATGGC	0.403			NA											8	34					5.18039e-06	6.34598e-06	0.00308	1	0
TGFBR3	7049	broad.mit.edu	37	1	92161256	92161256	+	Missense_Mutation	SNP	C	C	A			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr1:92161256C>A	uc001doh.2	-	16	2876	c.2410G>T	c.(2410-2412)GCC>TCC	p.A804S	TGFBR3_uc009wde.2_Missense_Mutation_p.A499S|TGFBR3_uc010osy.1_Missense_Mutation_p.A762S|TGFBR3_uc001doi.2_Missense_Mutation_p.A803S|TGFBR3_uc001doj.2_Missense_Mutation_p.A803S	NM_003243	NP_003234	Q03167	TGBR3_HUMAN	transforming growth factor, beta receptor III	804	Helical; (Potential).				BMP signaling pathway|cardiac epithelial to mesenchymal transition|cardiac muscle cell proliferation|cell growth|cell migration|definitive erythrocyte differentiation|heart trabecula formation|immune response|intracellular protein kinase cascade|liver development|negative regulation of cellular component movement|negative regulation of epithelial cell proliferation|palate development|pathway-restricted SMAD protein phosphorylation|response to follicle-stimulating hormone stimulus|response to luteinizing hormone stimulus|response to prostaglandin E stimulus|transforming growth factor beta receptor signaling pathway|ventricular cardiac muscle tissue morphogenesis	external side of plasma membrane|extracellular space|inhibin-betaglycan-ActRII complex|integral to plasma membrane|intracellular membrane-bounded organelle	coreceptor activity|heparin binding|PDZ domain binding|SMAD binding|transforming growth factor beta binding|transforming growth factor beta receptor activity, type III|type II transforming growth factor beta receptor binding			ovary(3)	3		all_lung(203;0.00719)|Lung NSC(277;0.0268)		all cancers(265;0.0108)|Epithelial(280;0.0825)		TACCACAAGGCCCCCGTCAGG	0.483			NA											8	104					1.12685e-05	1.3442e-05	0.004482	1	0
EVI5	7813	broad.mit.edu	37	1	93170268	93170268	+	Silent	SNP	A	A	G			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr1:93170268A>G	uc001dox.2	-	3	325	c.315T>C	c.(313-315)TCT>TCC	p.S105S	EVI5_uc010otf.1_Silent_p.S105S	NM_005665	NP_005656	O60447	EVI5_HUMAN	ecotropic viral integration site 5	105	Interaction with alpha-tubulin, gamma- tubulin, BIRC5 and FBXO5.|Ser-rich.				cell cycle|cell division|cell proliferation|multicellular organismal development	microtubule organizing center|nucleus|spindle	protein binding|Rab GTPase activator activity			ovary(1)|breast(1)	2		all_lung(203;0.00146)|Lung NSC(277;0.00565)|all_neural(321;0.185)|Melanoma(281;0.193)|Glioma(108;0.203)		Epithelial(280;8.09e-25)|OV - Ovarian serous cystadenocarcinoma(397;1.27e-22)|all cancers(265;1.74e-21)|GBM - Glioblastoma multiforme(16;0.00233)|BRCA - Breast invasive adenocarcinoma(282;0.211)		ACCCATTTACAGATCTTAAAG	0.368			NA											3	67					0	0	0.004672	0	0
COL11A1	1301	broad.mit.edu	37	1	103427822	103427822	+	Splice_Site	SNP	C	C	A			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr1:103427822C>A	uc001dul.2	-	40	3343	c.3025_splice	c.e40-1	p.G1009_splice	COL11A1_uc001duk.2_Splice_Site_p.G205_splice|COL11A1_uc001dum.2_Splice_Site_p.G1021_splice|COL11A1_uc001dun.2_Splice_Site_p.G970_splice|COL11A1_uc009weh.2_Splice_Site_p.G893_splice	NM_001854	NP_001845	P12107	COBA1_HUMAN	alpha 1 type XI collagen isoform A						collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			ovary(6)|breast(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	12		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		CTGGATCACCCTAAAGAATAT	0.388			NA											14	65					7.93312e-07	1.01678e-06	0.00245	1	0
COL11A1	1301	broad.mit.edu	37	1	103544311	103544311	+	Missense_Mutation	SNP	C	C	A			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr1:103544311C>A	uc001dul.2	-	3	709	c.391G>T	c.(391-393)GTT>TTT	p.V131F	COL11A1_uc001dum.2_Missense_Mutation_p.V131F|COL11A1_uc001dun.2_Missense_Mutation_p.V131F|COL11A1_uc009weh.2_Missense_Mutation_p.V131F	NM_001854	NP_001845	P12107	COBA1_HUMAN	alpha 1 type XI collagen isoform A	131	TSP N-terminal.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			ovary(6)|breast(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	12		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		GATCTCCCAACCTCAACACCA	0.383			NA											8	41					5.18039e-06	6.34598e-06	0.00308	1	0
RBM15	64783	broad.mit.edu	37	1	110883214	110883214	+	Missense_Mutation	SNP	G	G	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr1:110883214G>T	uc001dzl.1	+	1	1270	c.1187G>T	c.(1186-1188)CGC>CTC	p.R396L	RBM15_uc001dzm.1_Missense_Mutation_p.R396L|uc001dzj.2_5'Flank	NM_022768	NP_073605	Q96T37	RBM15_HUMAN	RNA binding motif protein 15	396	RRM 2.				interspecies interaction between organisms	nucleus	nucleotide binding|protein binding|RNA binding			ovary(3)	3		all_cancers(81;2.89e-06)|all_epithelial(167;2.96e-06)|all_lung(203;0.000116)|Lung NSC(277;0.000233)|Breast(1374;0.0634)		BRCA - Breast invasive adenocarcinoma(282;0.000224)|Epithelial(280;0.000476)|Kidney(133;0.000539)|KIRC - Kidney renal clear cell carcinoma(1967;0.000716)|all cancers(265;0.00144)|Lung(183;0.0238)|Colorectal(144;0.103)|LUSC - Lung squamous cell carcinoma(189;0.135)		GCGTTTGATCGCTTTGGAGTC	0.478			NA	T	MKL1	acute megakaryocytic leukemia								13	54					9.05144e-12	1.40972e-11	0.001855	1	0
HIPK1	204851	broad.mit.edu	37	1	114515660	114515660	+	Silent	SNP	G	G	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr1:114515660G>T	uc001eem.2	+	16	3320	c.3159G>T	c.(3157-3159)TCG>TCT	p.S1053S	HIPK1_uc001een.2_Silent_p.S1053S|HIPK1_uc001eeo.2_Silent_p.S679S|HIPK1_uc001eep.2_Silent_p.S659S|HIPK1_uc001eeq.2_Silent_p.S345S	NM_198268	NP_938009	Q86Z02	HIPK1_HUMAN	homeodomain-interacting protein kinase 1 isoform	1053	Interaction with TP53.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			ovary(4)	4	Lung SC(450;0.184)	all_cancers(81;4.5e-08)|all_epithelial(167;1.09e-07)|all_lung(203;1.53e-05)|Lung NSC(69;2.76e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		AGCAGTCATCGGCGGCTCCAA	0.587			NA											43	219					3.61848e-18	6.48686e-18	0.007835	1	0
GJA5	2702	broad.mit.edu	37	1	147231030	147231030	+	Missense_Mutation	SNP	C	C	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr1:147231030C>T	uc001eps.1	-	2	458	c.317G>A	c.(316-318)CGC>CAC	p.R106H	GJA5_uc001ept.1_Missense_Mutation_p.R106H	NM_181703	NP_859054	P36382	CXA5_HUMAN	connexin 40	106	Cytoplasmic (Potential).				angiogenesis|cell-cell junction assembly|muscle contraction	integral to membrane				ovary(1)	1	all_hematologic(923;0.0276)		LUSC - Lung squamous cell carcinoma(543;0.202)			CCGTAGCTTGCGCTTCTCCTG	0.617			NA											25	155					0	0	0.00278	0	0
PRUNE	58497	broad.mit.edu	37	1	151006393	151006393	+	Nonsense_Mutation	SNP	A	A	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr1:151006393A>T	uc001ewh.1	+	8	1181	c.1045A>T	c.(1045-1047)AAG>TAG	p.K349*	PRUNE_uc001ewi.1_Nonsense_Mutation_p.K167*|PRUNE_uc010pco.1_Nonsense_Mutation_p.K117*|PRUNE_uc001ewj.1_Nonsense_Mutation_p.K64*|PRUNE_uc001ewk.1_Nonsense_Mutation_p.K114*|BNIPL_uc009wmi.2_5'Flank|BNIPL_uc001ewl.2_5'Flank	NM_021222	NP_067045	Q86TP1	PRUNE_HUMAN	prune	349						cytoplasm|focal adhesion|nucleus	inorganic diphosphatase activity|manganese ion binding|protein binding			ovary(1)	1	all_lung(15;1.09e-34)|Lung NSC(24;1.1e-30)|Lung SC(34;0.00202)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.211)			GGTCTCTCGAAAGAAACTTCT	0.557			NA											71	175					0	0	0.01441	0	0
HRNR	388697	broad.mit.edu	37	1	152191370	152191370	+	Missense_Mutation	SNP	C	C	A	rs146160152	byFrequency	TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr1:152191370C>A	uc001ezt.1	-	3	2811	c.2735G>T	c.(2734-2736)GGC>GTC	p.G912V		NM_001009931	NP_001009931	Q86YZ3	HORN_HUMAN	hornerin	912	10.				keratinization		calcium ion binding|protein binding			skin(2)|ovary(1)	3	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CCGACCGGAGCCAGACCCATG	0.642			NA											43	330					7.63091e-17	1.34279e-16	0.007835	1	0
HRNR	388697	broad.mit.edu	37	1	152193475	152193475	+	Silent	SNP	A	A	G			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr1:152193475A>G	uc001ezt.1	-	3	706	c.630T>C	c.(628-630)TCT>TCC	p.S210S		NM_001009931	NP_001009931	Q86YZ3	HORN_HUMAN	hornerin	210	2.				keratinization		calcium ion binding|protein binding			skin(2)|ovary(1)	3	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GTCCGGAGCCAGAGCCGTGTT	0.572			NA											34	225					0	0	0.010818	0	0
LCE1F	353137	broad.mit.edu	37	1	152749092	152749092	+	Missense_Mutation	SNP	G	G	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr1:152749092G>T	uc010pdv.1	+	1	245	c.245G>T	c.(244-246)CGG>CTG	p.R82L		NM_178354	NP_848131	Q5T754	LCE1F_HUMAN	late cornified envelope 1F	82	Poly-Arg.				keratinization						0	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			CACCACAGACGGCGTAGGTCC	0.701			NA											8	78					0.000157383	0.00017807	0.00308	1	0
FCRL1	115350	broad.mit.edu	37	1	157769856	157769856	+	Silent	SNP	A	A	G			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr1:157769856A>G	uc001frg.2	-	7	1136	c.1023T>C	c.(1021-1023)GAT>GAC	p.D341D	FCRL1_uc001frf.2_RNA|FCRL1_uc001frh.2_Silent_p.D341D|FCRL1_uc001fri.2_Silent_p.D302D|FCRL1_uc001frj.2_RNA	NM_052938	NP_443170	Q96LA6	FCRL1_HUMAN	Fc receptor-like 1 isoform 1 precursor	341	Cytoplasmic (Potential).					integral to membrane|plasma membrane	receptor activity			skin(4)|ovary(3)	7	all_hematologic(112;0.0378)		LUSC - Lung squamous cell carcinoma(543;0.24)			ACCTGAGTGGATCCCTGGCTG	0.388	GBM(54;482 1003 11223 30131 35730)		NA											9	37					0	0	0.008291	0	0
OR10K2	391107	broad.mit.edu	37	1	158389873	158389873	+	Missense_Mutation	SNP	G	G	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr1:158389873G>T	uc010pii.1	-	1	784	c.784C>A	c.(784-786)CCT>ACT	p.P262T		NM_001004476	NP_001004476	Q6IF99	O10K2_HUMAN	olfactory receptor, family 10, subfamily K,	262	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(1)	1	all_hematologic(112;0.0378)					TTGGACTGAGGCCTTAAGTAG	0.413			NA											17	92					3.99206e-14	6.60504e-14	0.007413	1	0
OR10R2	343406	broad.mit.edu	37	1	158449763	158449763	+	Missense_Mutation	SNP	C	C	A			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr1:158449763C>A	uc010pik.1	+	1	96	c.96C>A	c.(94-96)TTC>TTA	p.F32L	uc001fso.1_RNA	NM_001004472	NP_001004472	Q8NGX6	O10R2_HUMAN	olfactory receptor, family 10, subfamily R,	32	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(2)|skin(1)	3	all_hematologic(112;0.0378)					TCACCGAATTCCTGTTGCTGG	0.413			NA											37	145					4.62619e-21	8.49246e-21	0.004289	1	0
SPTA1	6708	broad.mit.edu	37	1	158627314	158627314	+	Missense_Mutation	SNP	G	G	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr1:158627314G>T	uc001fst.1	-	19	2957	c.2758C>A	c.(2758-2760)CCT>ACT	p.P920T		NM_003126	NP_003117	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1	920	Spectrin 10.				actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|breast(1)	8	all_hematologic(112;0.0378)					TCTACAATAGGTTCCTTCTCT	0.458			NA											27	153					4.72057e-08	6.42522e-08	0.003954	1	0
SPTA1	6708	broad.mit.edu	37	1	158645987	158645988	+	Missense_Mutation	DNP	CC	CC	AA			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr1:158645987_158645988CC>AA	uc001fst.1	-	8	1254_1255	c.1055_1056GG>TT	c.(1054-1056)TGG>TTT	p.W352F		NM_003126	NP_003117	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1	352	Spectrin 4.				actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|breast(1)	8	all_hematologic(112;0.0378)					GAATATGCTCCCAGCTGGAGAC	0.485			NA											39	100					0	0	0.004672	0	0
FCRLA	84824	broad.mit.edu	37	1	161683163	161683163	+	Missense_Mutation	SNP	C	C	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr1:161683163C>T	uc001gbe.2	+	6	1384	c.1142C>T	c.(1141-1143)GCT>GTT	p.A381V	FCRLA_uc001gbd.2_Missense_Mutation_p.A375V|FCRLA_uc001gbf.2_Missense_Mutation_p.A286V|FCRLA_uc001gbg.2_Missense_Mutation_p.A235V|FCRLA_uc009wuo.2_Missense_Mutation_p.A241V|FCRLA_uc009wup.2_Missense_Mutation_p.A191V|FCRLA_uc009wuq.2_Missense_Mutation_p.A140V	NM_032738	NP_116127	Q7L513	FCRLA_HUMAN	Fc receptor-like and mucin-like 1	358					cell differentiation	cytoplasm|extracellular region					0	all_cancers(52;2.55e-15)|all_hematologic(112;0.0359)		BRCA - Breast invasive adenocarcinoma(70;0.00301)			AAGGCTACTGCTGAATAGAAG	0.453			NA											8	74					0	0	0.004482	0	0
DUSP12	11266	broad.mit.edu	37	1	161722885	161722885	+	Missense_Mutation	SNP	C	C	G			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr1:161722885C>G	uc001gbo.2	+	5	706	c.695C>G	c.(694-696)TCT>TGT	p.S232C	DUSP12_uc001gbp.2_Missense_Mutation_p.S102C	NM_007240	NP_009171	Q9UNI6	DUS12_HUMAN	dual specificity phosphatase 12	232					positive regulation of glucokinase activity	cytoplasm|nucleus	protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity|zinc ion binding			breast(1)	1	all_hematologic(112;0.0359)		BRCA - Breast invasive adenocarcinoma(70;0.00634)			TTTCGAAGTTCTAGTATTCTG	0.418			NA											43	110					0	0	0.009718	0	0
UCK2	7371	broad.mit.edu	37	1	165859550	165859550	+	Missense_Mutation	SNP	C	C	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr1:165859550C>T	uc001gdp.2	+	2	390	c.209C>T	c.(208-210)TCG>TTG	p.S70L	UCK2_uc010plb.1_5'UTR	NM_012474	NP_036606	Q9BZX2	UCK2_HUMAN	uridine-cytidine kinase 2	70					pyrimidine base metabolic process|pyrimidine nucleoside salvage	cytosol	ATP binding|phosphotransferase activity, alcohol group as acceptor|uridine kinase activity			ovary(1)	1	all_hematologic(923;0.048)|Acute lymphoblastic leukemia(8;0.155)					GTCCTTACCTCGGAGCAGAAG	0.562			NA											13	71					0	0	0.013537	0	0
POU2F1	5451	broad.mit.edu	37	1	167381288	167381288	+	Missense_Mutation	SNP	T	T	C			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr1:167381288T>C	uc001gec.2	+	15	1741	c.1579T>C	c.(1579-1581)TCC>CCC	p.S527P	POU2F1_uc001ged.2_Missense_Mutation_p.S525P|POU2F1_uc001gee.2_Missense_Mutation_p.S527P|POU2F1_uc010plh.1_Missense_Mutation_p.S464P|POU2F1_uc001gef.2_Missense_Mutation_p.S539P|POU2F1_uc001geg.2_Missense_Mutation_p.S425P|POU2F1_uc009wvg.1_RNA	NM_002697	NP_002688	P14859	PO2F1_HUMAN	POU class 2 homeobox 1	527					negative regulation of transcription, DNA-dependent|transcription from RNA polymerase III promoter	nucleoplasm	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(2)|skin(2)|breast(1)	5						TCTGAGTCCCTCCCCTTCTGC	0.592			NA											3	65					0	0	0.004672	0	0
BAT2L2	23215	broad.mit.edu	37	1	171504671	171504671	+	Missense_Mutation	SNP	G	G	A			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr1:171504671G>A	uc010pmg.1	+	13	2238	c.1972G>A	c.(1972-1974)GCT>ACT	p.A658T		NM_015172	NP_055987	Q9Y520	PRC2C_HUMAN	HBxAg transactivated protein 2	658							protein C-terminus binding				0						ACCTCGGCCGGCTGTATTATC	0.443			NA											25	151					0	0	0.004656	0	0
RFWD2	64326	broad.mit.edu	37	1	176153798	176153798	+	Silent	SNP	T	T	C			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr1:176153798T>C	uc001gku.1	-	2	694	c.438A>G	c.(436-438)GCA>GCG	p.A146A	RFWD2_uc001gkv.1_Silent_p.A146A|RFWD2_uc001gkw.1_5'UTR|RFWD2_uc001gkt.1_Silent_p.A5A	NM_022457	NP_071902	Q8NHY2	RFWD2_HUMAN	ring finger and WD repeat domain 2 isoform a	146	RING-type.				DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	centrosome|cytosol|focal adhesion|nuclear speck	protein binding|ubiquitin-protein ligase activity|zinc ion binding				0						TTGTCATGTATGCTTCTTCAA	0.279	Ovarian(134;1413 1765 5706 35534 51541)		NA											28	146					0	0	0.009535	0	0
PRG4	10216	broad.mit.edu	37	1	186275895	186275895	+	Silent	SNP	G	G	A			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr1:186275895G>A	uc001gru.3	+	7	1095	c.1044G>A	c.(1042-1044)AAG>AAA	p.K348K	PRG4_uc001grt.3_Silent_p.K307K|PRG4_uc009wyl.2_Silent_p.K255K|PRG4_uc009wym.2_Silent_p.K214K|PRG4_uc010poo.1_RNA	NM_005807	NP_005798	Q92954	PRG4_HUMAN	proteoglycan 4 isoform A	348	59 X 8 AA repeats of K-X-P-X-P-T-T-X.|1.				cell proliferation|immune response	extracellular region	polysaccharide binding|protein binding|scavenger receptor activity			skin(1)	1						CCACTCCCAAGGAGCCCACGC	0.547			NA											54	134					0	0	0.01441	0	0
CFHR2	3080	broad.mit.edu	37	1	196927062	196927062	+	Nonsense_Mutation	SNP	G	G	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr1:196927062G>T	uc001gtq.1	+	4	549	c.472G>T	c.(472-474)GGA>TGA	p.G158*	CFHR2_uc001gtr.1_Nonsense_Mutation_p.G34*	NM_005666	NP_005657	P36980	FHR2_HUMAN	H factor (complement)-like 3 precursor	158	Sushi 3.					extracellular region				skin(2)|ovary(1)	3						TATTGACAATGGAGACATTAC	0.373			NA											13	91					4.36969e-10	6.41358e-10	0.001855	1	0
ASPM	259266	broad.mit.edu	37	1	197065239	197065239	+	Missense_Mutation	SNP	C	C	A			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr1:197065239C>A	uc001gtu.2	-	19	9133	c.8876G>T	c.(8875-8877)TGC>TTC	p.C2959F	ASPM_uc001gtv.2_Missense_Mutation_p.C1374F|ASPM_uc001gtw.3_Missense_Mutation_p.C807F	NM_018136	NP_060606	Q8IZT6	ASPM_HUMAN	asp (abnormal spindle)-like, microcephaly	2959	IQ 35.|IQ 34.				mitosis	cytoplasm|nucleus	calmodulin binding			ovary(4)|central_nervous_system(2)	6						TTGAATCTTGCAGGCAGCTTT	0.328			NA											69	168					2.23399e-28	4.21022e-28	0.01441	1	0
CRB1	23418	broad.mit.edu	37	1	197396975	197396975	+	Silent	SNP	G	G	A			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr1:197396975G>A	uc001gtz.2	+	7	2655	c.2520G>A	c.(2518-2520)GAG>GAA	p.E840E	CRB1_uc010poz.1_Silent_p.E771E|CRB1_uc010ppa.1_RNA|CRB1_uc009wza.2_Silent_p.E728E|CRB1_uc010ppb.1_Intron|CRB1_uc010ppc.1_RNA|CRB1_uc010ppd.1_Silent_p.E321E|CRB1_uc001gub.1_Silent_p.E489E	NM_201253	NP_957705	P82279	CRUM1_HUMAN	crumbs homolog 1 precursor	840	Extracellular (Potential).|Laminin G-like 2.				cell-cell signaling|establishment or maintenance of cell polarity	apical plasma membrane|extracellular region|integral to membrane	calcium ion binding|protein binding			ovary(5)|skin(3)|large_intestine(1)	9						ACAAGCAAGAGACTGAACTTA	0.388			NA											10	24					0	0	0.008291	0	0
KIF21B	23046	broad.mit.edu	37	1	200978394	200978394	+	Missense_Mutation	SNP	C	C	A			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr1:200978394C>A	uc001gvs.1	-	2	581	c.264G>T	c.(262-264)CAG>CAT	p.Q88H	KIF21B_uc001gvr.1_Missense_Mutation_p.Q88H|KIF21B_uc009wzl.1_Missense_Mutation_p.Q88H|KIF21B_uc010ppn.1_Missense_Mutation_p.Q88H	NM_017596	NP_060066	O75037	KI21B_HUMAN	kinesin family member 21B	88	Kinesin-motor.|ATP (By similarity).				microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(3)|skin(3)	6						GATGGCTTACCTGCCCATAGG	0.562			NA											13	25					2.27111e-07	2.99523e-07	0.013537	1	0
PPP1R12B	4660	broad.mit.edu	37	1	202318255	202318255	+	Missense_Mutation	SNP	G	G	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr1:202318255G>T	uc001gya.1	+	1	420	c.276G>T	c.(274-276)TTG>TTT	p.L92F	PPP1R12B_uc001gxy.2_Missense_Mutation_p.L92F|PPP1R12B_uc009xad.1_5'UTR|PPP1R12B_uc009xae.1_Missense_Mutation_p.L92F|PPP1R12B_uc001gxz.1_Missense_Mutation_p.L92F	NM_002481	NP_002472	O60237	MYPT2_HUMAN	protein phosphatase 1, regulatory (inhibitor)	92	ANK 2.				regulation of muscle contraction|signal transduction	cytoplasm	enzyme activator activity			ovary(3)	3			BRCA - Breast invasive adenocarcinoma(75;0.166)			TGGACGGCTTGACAGCCCTGC	0.572			NA											23	41					2.21704e-12	3.52182e-12	0.00278	1	0
IKBKE	9641	broad.mit.edu	37	1	206666379	206666379	+	Missense_Mutation	SNP	A	A	G			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr1:206666379A>G	uc001hdz.1	+	19	2227	c.1859A>G	c.(1858-1860)CAC>CGC	p.H620R	IKBKE_uc009xbv.1_Missense_Mutation_p.H620R|IKBKE_uc001hea.1_Missense_Mutation_p.H535R	NM_014002	NP_054721	Q14164	IKKE_HUMAN	IKK-related kinase epsilon	620					DNA damage response, signal transduction resulting in induction of apoptosis|innate immune response|MyD88-independent toll-like receptor signaling pathway|negative regulation of type I interferon production|positive regulation of I-kappaB kinase/NF-kappaB cascade|Toll signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|endosome membrane|plasma membrane|PML body	ATP binding|IkappaB kinase activity|NF-kappaB-inducing kinase activity|protein binding			ovary(3)|lung(3)|central_nervous_system(1)|skin(1)	8	Breast(84;0.137)					ACCAGGAACCACCTGCGCCTG	0.582			NA											4	16					0	0	0.000602	0	0
KCNK2	3776	broad.mit.edu	37	1	215342686	215342686	+	Missense_Mutation	SNP	T	T	C			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr1:215342686T>C	uc001hkq.2	+	4	789	c.620T>C	c.(619-621)GTG>GCG	p.V207A	KCNK2_uc001hko.2_Missense_Mutation_p.V203A|KCNK2_uc009xdm.2_RNA|KCNK2_uc001hkp.2_RNA|KCNK2_uc010pua.1_RNA|KCNK2_uc001hkr.3_Missense_Mutation_p.V192A	NM_001017425	NP_001017425	O95069	KCNK2_HUMAN	potassium channel, subfamily K, member 2 isoform	207	Cytoplasmic (Potential).						outward rectifier potassium channel activity				0				OV - Ovarian serous cystadenocarcinoma(81;0.0399)|all cancers(67;0.0556)|GBM - Glioblastoma multiforme(131;0.068)	Dofetilide(DB00204)	attgccaaagtggaAGATACG	0.204			NA											13	36					0	0	0.013537	0	0
USH2A	7399	broad.mit.edu	37	1	216369929	216369929	+	Nonsense_Mutation	SNP	G	G	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr1:216369929G>T	uc001hku.1	-	19	4604	c.4217C>A	c.(4216-4218)TCA>TAA	p.S1406*	USH2A_uc001hkv.2_Nonsense_Mutation_p.S1406*	NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	1406	Extracellular (Potential).|Fibronectin type-III 4.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		CTGTTGAGGTGATTGTTCAGA	0.393			NA								HNSCC(13;0.011)			14	69					1.15088e-07	1.5337e-07	0.004007	1	0
MARK1	4139	broad.mit.edu	37	1	220792037	220792037	+	Missense_Mutation	SNP	C	C	G			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr1:220792037C>G	uc001hmn.3	+	9	1446	c.849C>G	c.(847-849)GAC>GAG	p.D283E	MARK1_uc009xdw.2_Missense_Mutation_p.D283E|MARK1_uc010pun.1_Missense_Mutation_p.D283E|MARK1_uc001hmm.3_Missense_Mutation_p.D261E	NM_018650	NP_061120	Q9P0L2	MARK1_HUMAN	MAP/microtubule affinity-regulating kinase 1	283	Protein kinase.				intracellular protein kinase cascade	cytoplasm|microtubule cytoskeleton	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			ovary(4)|central_nervous_system(2)|skin(2)|stomach(1)|lung(1)	10				GBM - Glioblastoma multiforme(131;0.0407)		TGTCCACAGACTGTGAAAATC	0.333			NA											5	53					0	0	0.000602	0	0
C1orf65	164127	broad.mit.edu	37	1	223567834	223567834	+	Silent	SNP	G	G	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr1:223567834G>T	uc001hoa.2	+	1	1120	c.1017G>T	c.(1015-1017)GTG>GTT	p.V339V		NM_152610	NP_689823	Q8N715	CA065_HUMAN	hypothetical protein LOC164127	339										central_nervous_system(1)|skin(1)	2				GBM - Glioblastoma multiforme(131;0.0704)		GGAAGAACGTGCCCCCGGGGG	0.687			NA											6	12					0.00116845	0.00128549	0.001168	1	0
LBR	3930	broad.mit.edu	37	1	225609925	225609925	+	Nonsense_Mutation	SNP	T	T	A			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr1:225609925T>A	uc001hoy.2	-	3	363	c.220A>T	c.(220-222)AGA>TGA	p.R74*	LBR_uc001hoz.2_Nonsense_Mutation_p.R74*|LBR_uc001hpa.1_Nonsense_Mutation_p.R74*	NM_002296	NP_002287	Q14739	LBR_HUMAN	lamin B receptor	74	Nucleoplasmic (Potential).				cholesterol biosynthetic process	integral to nuclear inner membrane	chromo shadow domain binding|delta14-sterol reductase activity|DNA binding|lamin binding|receptor activity			ovary(1)|skin(1)	2	Breast(184;0.165)			GBM - Glioblastoma multiforme(131;0.117)		CCTCGGCGTCTGGAAGGGGAA	0.527			NA											14	59					0	0	0.00245	0	0
LEFTY2	7044	broad.mit.edu	37	1	226125399	226125399	+	Missense_Mutation	SNP	C	C	G			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr1:226125399C>G	uc001hpt.1	-	4	923	c.843G>C	c.(841-843)TGG>TGC	p.W281C	LEFTY2_uc010pvk.1_Missense_Mutation_p.W247C|LEFTY2_uc009xek.1_3'UTR	NM_003240	NP_003231	O00292	LFTY2_HUMAN	endometrial bleeding associated factor	281					cell growth|multicellular organismal development|platelet activation|platelet degranulation|transforming growth factor beta receptor signaling pathway	extracellular space|platelet alpha granule lumen	cytokine activity|growth factor activity|transforming growth factor beta receptor binding				0	Breast(184;0.197)					GCTCCAGCACCCAGTTCTTGG	0.652	Colon(172;116 2643 9098 43333)		NA											14	26					0	0	0.001855	0	0
SLC35F3	148641	broad.mit.edu	37	1	234367270	234367270	+	Nonsense_Mutation	SNP	C	C	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr1:234367270C>T	uc001hwa.1	+	2	412	c.184C>T	c.(184-186)CAA>TAA	p.Q62*	SLC35F3_uc001hvy.1_Nonsense_Mutation_p.Q131*	NM_173508	NP_775779	Q8IY50	S35F3_HUMAN	solute carrier family 35, member F3	62					transport	integral to membrane				ovary(2)	2	Ovarian(103;0.0454)	all_cancers(173;0.145)|Prostate(94;0.0885)	OV - Ovarian serous cystadenocarcinoma(106;0.00531)			CTCCCGGGCGCAACTCAAGAA	0.731			NA											15	110					0	0	0.00499	0	0
ACTN2	88	broad.mit.edu	37	1	236902752	236902752	+	Missense_Mutation	SNP	A	A	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr1:236902752A>T	uc001hyf.2	+	10	1231	c.1027A>T	c.(1027-1029)ATC>TTC	p.I343F	ACTN2_uc001hyg.2_Missense_Mutation_p.I135F|ACTN2_uc009xgi.1_Missense_Mutation_p.I343F|ACTN2_uc010pxu.1_Intron|ACTN2_uc001hyh.2_Missense_Mutation_p.I31F	NM_001103	NP_001094	P35609	ACTN2_HUMAN	actinin, alpha 2	343	Spectrin 1.				focal adhesion assembly|microspike assembly|muscle filament sliding|platelet activation|platelet degranulation|protein homotetramerization|regulation of apoptosis|synaptic transmission	actin filament|cytosol|dendritic spine|extracellular region|filopodium|focal adhesion|nucleolus|platelet alpha granule lumen|pseudopodium|Z disc	actin binding|calcium ion binding|FATZ 1 binding|identical protein binding|integrin binding|protein dimerization activity|structural constituent of muscle|titin binding|titin Z domain binding|ZASP binding			ovary(4)|skin(1)	5	Ovarian(103;0.0634)|Breast(184;0.221)	all_cancers(173;0.00661)|Acute lymphoblastic leukemia(190;0.109)|Prostate(94;0.174)	OV - Ovarian serous cystadenocarcinoma(106;0.00168)			CCAGCTGGAGATCAACTTCAA	0.582			NA											16	88					0	0	0.003163	0	0
MTR	4548	broad.mit.edu	37	1	237024505	237024505	+	Missense_Mutation	SNP	T	T	G			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr1:237024505T>G	uc001hyi.3	+	20	2547	c.2124T>G	c.(2122-2124)ATT>ATG	p.I708M	MTR_uc010pxw.1_Missense_Mutation_p.I301M|MTR_uc010pxx.1_Intron|MTR_uc010pxy.1_Missense_Mutation_p.I562M	NM_000254	NP_000245	Q99707	METH_HUMAN	5-methyltetrahydrofolate-homocysteine	708	B12-binding N-terminal.				nervous system development|xenobiotic metabolic process	cytosol	cobalamin binding|homocysteine S-methyltransferase activity|methionine synthase activity|protein binding|zinc ion binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3	Ovarian(103;0.0634)|Breast(184;0.221)	all_cancers(173;2.79e-22)|all_epithelial(177;4.84e-14)|Breast(1374;0.00123)|Prostate(94;0.0181)|Lung SC(1967;0.0262)|Acute lymphoblastic leukemia(190;0.117)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)	KIRC - Kidney renal clear cell carcinoma(1967;0.248)	Hydroxocobalamin(DB00200)|L-Methionine(DB00134)|Tetrahydrofolic acid(DB00116)	TCAATATAATTGAAGGACCCC	0.333			NA											13	75					0	0	0.00245	0	0
RYR2	6262	broad.mit.edu	37	1	237993846	237993846	+	Missense_Mutation	SNP	G	G	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr1:237993846G>T	uc001hyl.1	+	103	14792	c.14672G>T	c.(14671-14673)TGT>TTT	p.C4891F	RYR2_uc010pyb.1_Intron	NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	4891					cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			TGCTTCATCTGTGGGATAGGC	0.428			NA											20	139					7.21436e-19	1.30555e-18	0.008871	1	0
CHRM3	1131	broad.mit.edu	37	1	240071786	240071786	+	Silent	SNP	C	C	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr1:240071786C>T	uc001hyp.2	+	5	1814	c.1035C>T	c.(1033-1035)TCC>TCT	p.S345S		NM_000740	NP_000731	P20309	ACM3_HUMAN	cholinergic receptor, muscarinic 3	345	Cytoplasmic (By similarity).				cell proliferation|energy reserve metabolic process|nervous system development|protein modification process|regulation of insulin secretion	basolateral plasma membrane|cell junction|integral to plasma membrane|postsynaptic membrane	muscarinic acetylcholine receptor activity|phosphatidylinositol phospholipase C activity			ovary(4)|skin(1)	5	Ovarian(103;0.127)	all_cancers(173;0.00567)|all_neural(198;0.203)	OV - Ovarian serous cystadenocarcinoma(106;0.00989)		Anisotropine Methylbromide(DB00517)|Atropine(DB00572)|Benzquinamide(DB00767)|Cevimeline(DB00185)|Cryptenamine(DB00785)|Cyclizine(DB01176)|Darifenacin(DB00496)|Diphemanil Methylsulfate(DB00729)|Diphenidol(DB01231)|Homatropine Methylbromide(DB00725)|Methotrimeprazine(DB01403)|Metixene(DB00340)|Olanzapine(DB00334)|Oxybutynin(DB01062)|Oxyphencyclimine(DB00383)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Solifenacin(DB01591)|Thiethylperazine(DB00372)|Tiotropium(DB01409)|Tolterodine(DB01036)|Tridihexethyl(DB00505)	CTGCTGCCTCCCTGGAGAACT	0.567			NA											11	26					0	0	0.008291	0	0
OR13G1	441933	broad.mit.edu	37	1	247836182	247836182	+	Silent	SNP	C	C	A			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr1:247836182C>A	uc001idi.1	-	1	162	c.162G>T	c.(160-162)ACG>ACT	p.T54T		NM_001005487	NP_001005487	Q8NGZ3	O13G1_HUMAN	olfactory receptor, family 13, subfamily G,	54	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.017)			CATACATGGGCGTATGCAAGG	0.418			NA											17	35					3.52763e-06	4.34642e-06	0.00499	1	0
OR11L1	391189	broad.mit.edu	37	1	248004298	248004298	+	Missense_Mutation	SNP	C	C	A			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr1:248004298C>A	uc001idn.1	-	1	901	c.901G>T	c.(901-903)GTT>TTT	p.V301F		NM_001001959	NP_001001959	Q8NGX0	O11L1_HUMAN	olfactory receptor, family 11, subfamily L,	301	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|pancreas(1)|skin(1)	3	all_cancers(71;8.78e-05)|all_epithelial(71;9.15e-06)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.0786)|Lung NSC(105;0.0858)		OV - Ovarian serous cystadenocarcinoma(106;0.0319)			ACCTTTCTAACAGCTTCTTTG	0.393			NA											28	69					2.48779e-11	3.83711e-11	0.005443	1	0
OR2W3	343171	broad.mit.edu	37	1	248059468	248059468	+	Missense_Mutation	SNP	G	G	A			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr1:248059468G>A	uc001idp.1	+	3	849	c.580G>A	c.(580-582)GCC>ACC	p.A194T	OR2W3_uc010pzb.1_Missense_Mutation_p.A194T	NM_001001957	NP_001001957	Q7Z3T1	OR2W3_HUMAN	olfactory receptor, family 2, subfamily W,	194	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|breast(1)|pancreas(1)	3	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0319)			CAGCACTGTGGCCATCGAAGG	0.602			NA											11	124					0	0	0.00333	0	0
OR2T8	343172	broad.mit.edu	37	1	248085207	248085207	+	Missense_Mutation	SNP	G	G	T	rs151007478	byFrequency	TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr1:248085207G>T	uc010pzc.1	+	1	888	c.888G>T	c.(886-888)AAG>AAT	p.K296N		NM_001005522	NP_001005522	A6NH00	OR2T8_HUMAN	olfactory receptor, family 2, subfamily T,	296	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)	all_cancers(173;0.0211)	OV - Ovarian serous cystadenocarcinoma(106;0.0319)			GTGAGGTGAAGGGAGCCCTGA	0.463			NA											63	157					1.02016e-41	1.95735e-41	0.01441	1	0
OR2L1P	26247	broad.mit.edu	37	1	248154016	248154016	+	Missense_Mutation	SNP	G	G	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr1:248154016G>T	uc001idv.1	+	1	448	c.204G>T	c.(202-204)ATG>ATT	p.M68I	OR2L13_uc001ids.2_Intron	NR_002145				RecName: Full=Olfactory receptor 2L5; AltName: Full=Olfactory receptor OR1-53;												0						GATCTTGGATGATAGGCTCCA	0.438			NA											20	125					4.63292e-17	8.1977e-17	0.008871	1	0
SH3BP5L	80851	broad.mit.edu	37	1	249106196	249106196	+	Missense_Mutation	SNP	C	C	A			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr1:249106196C>A	uc001iew.1	-	7	1637	c.1085G>T	c.(1084-1086)AGT>ATT	p.S362I	SH3BP5L_uc010pzp.1_Missense_Mutation_p.S255I|SH3BP5L_uc010pzq.1_Missense_Mutation_p.S330I|SH3BP5L_uc001iev.1_Missense_Mutation_p.S243I	NM_030645	NP_085148	Q7L8J4	3BP5L_HUMAN	SH3-binding domain protein 5-like	362											0	all_cancers(71;3.33e-06)|all_epithelial(71;2.41e-06)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.0458)|Lung NSC(105;0.0494)|Melanoma(84;0.199)	all_cancers(173;0.19)	OV - Ovarian serous cystadenocarcinoma(106;0.00805)			GCCGTCCAGACTGACGTGGTC	0.692			NA											9	23					1.76689e-08	2.45209e-08	0.006214	1	0
GDI2	2665	broad.mit.edu	37	10	5808594	5808594	+	Silent	SNP	G	G	A			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr10:5808594G>A	uc001iil.3	-	9	1290	c.999C>T	c.(997-999)TAC>TAT	p.Y333Y	GDI2_uc001iim.3_Silent_p.Y288Y|GDI2_uc009xid.2_Silent_p.Y337Y	NM_001494	NP_001485	P50395	GDIB_HUMAN	GDP dissociation inhibitor 2 isoform 1	333					protein transport|small GTPase mediated signal transduction	cell surface|cytosol|membrane	protein binding|Rab GDP-dissociation inhibitor activity				0						TCATGCAGACGTAGATATCTA	0.448			NA											11	72					0	0	0.008291	0	0
PRKCQ	5588	broad.mit.edu	37	10	6527227	6527227	+	Missense_Mutation	SNP	C	C	A			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr10:6527227C>A	uc001ijj.1	-	10	980	c.905G>T	c.(904-906)CGC>CTC	p.R302L	PRKCQ_uc009xim.1_Missense_Mutation_p.R302L|PRKCQ_uc001iji.1_Missense_Mutation_p.R335L|PRKCQ_uc009xin.1_Missense_Mutation_p.R266L|PRKCQ_uc010qax.1_Missense_Mutation_p.R177L	NM_006257	NP_006248	Q04759	KPCT_HUMAN	protein kinase C, theta	302					axon guidance|cellular component disassembly involved in apoptosis|intracellular signal transduction|membrane protein ectodomain proteolysis|platelet activation|regulation of cell growth|T cell receptor signaling pathway	cytosol	ATP binding|metal ion binding|protein binding|protein kinase C activity			ovary(3)|lung(2)|large_intestine(1)	6						TCTTAAGCAGCGAGCCTGGAT	0.488	Ovarian(50;572 1126 10530 25349 30594)		NA											20	89					8.00594e-06	9.65868e-06	0.007413	1	0
GPR158	57512	broad.mit.edu	37	10	25701316	25701316	+	Nonsense_Mutation	SNP	C	C	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr10:25701316C>T	uc001isj.2	+	4	1309	c.1249C>T	c.(1249-1251)CGA>TGA	p.R417*		NM_020752	NP_065803	Q5T848	GP158_HUMAN	G protein-coupled receptor 158 precursor	417	Extracellular (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(4)|large_intestine(2)|pancreas(1)|skin(1)	8						TAAGTATTTACGACTTGCCAT	0.512			NA											7	223					0	0	0.006214	0	0
GAD2	2572	broad.mit.edu	37	10	26559665	26559665	+	Missense_Mutation	SNP	A	A	G			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr10:26559665A>G	uc001isp.2	+	10	1575	c.1072A>G	c.(1072-1074)AAG>GAG	p.K358E	GAD2_uc001isq.2_Missense_Mutation_p.K358E	NM_001134366	NP_001127838	Q05329	DCE2_HUMAN	glutamate decarboxylase 2	358					glutamate decarboxylation to succinate|neurotransmitter biosynthetic process|neurotransmitter secretion	cell junction|clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|cytosol|Golgi membrane|presynaptic membrane	glutamate decarboxylase activity|protein binding|pyridoxal phosphate binding			central_nervous_system(1)|skin(1)	2					L-Glutamic Acid(DB00142)	CAAAAAGTATAAGATCTGGAT	0.468			NA											22	111					0	0	0.014323	0	0
PCDH15	65217	broad.mit.edu	37	10	56128918	56128918	+	Missense_Mutation	SNP	T	T	A			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr10:56128918T>A	uc001jju.1	-	5	831	c.436A>T	c.(436-438)ACT>TCT	p.T146S	PCDH15_uc010qhq.1_Missense_Mutation_p.T151S|PCDH15_uc010qhr.1_Missense_Mutation_p.T146S|PCDH15_uc010qhs.1_Missense_Mutation_p.T151S|PCDH15_uc010qht.1_Missense_Mutation_p.T146S|PCDH15_uc010qhu.1_Missense_Mutation_p.T146S|PCDH15_uc001jjv.1_Missense_Mutation_p.T124S|PCDH15_uc010qhv.1_Missense_Mutation_p.T146S|PCDH15_uc010qhw.1_Missense_Mutation_p.T146S|PCDH15_uc010qhx.1_Missense_Mutation_p.T146S|PCDH15_uc010qhy.1_Missense_Mutation_p.T151S|PCDH15_uc010qhz.1_Missense_Mutation_p.T146S|PCDH15_uc010qia.1_Missense_Mutation_p.T124S|PCDH15_uc010qib.1_Missense_Mutation_p.T124S|PCDH15_uc001jjw.2_Missense_Mutation_p.T146S	NM_033056	NP_149045	Q96QU1	PCD15_HUMAN	protocadherin 15 isoform CD1-4 precursor	146	Cadherin 1.|Extracellular (Potential).				equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			pancreas(5)|ovary(4)|upper_aerodigestive_tract(2)|skin(2)	13		Melanoma(3;0.117)|Lung SC(717;0.238)				TGCTTGAAAGTGGGTGAGTTG	0.408			NA								HNSCC(58;0.16)			7	27					0	0	0.00308	0	0
HERC4	26091	broad.mit.edu	37	10	69700789	69700789	+	Missense_Mutation	SNP	A	A	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr10:69700789A>T	uc001jng.3	-	21	2746	c.2435T>A	c.(2434-2436)GTG>GAG	p.V812E	HERC4_uc009xpq.2_Missense_Mutation_p.V345E|HERC4_uc001jnf.3_RNA|HERC4_uc001jnh.3_Missense_Mutation_p.V804E|HERC4_uc009xpr.2_Intron|HERC4_uc001jni.3_Missense_Mutation_p.V548E	NM_022079	NP_071362	Q5GLZ8	HERC4_HUMAN	hect domain and RLD 4 isoform a	812	HECT.				cell differentiation|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|spermatogenesis	cytosol	ubiquitin-protein ligase activity			ovary(1)|breast(1)|skin(1)	3						ATGGAGGTCCACAATGGTACA	0.333			NA											19	70					0	0	0.010504	0	0
GRID1	2894	broad.mit.edu	37	10	87484184	87484184	+	Missense_Mutation	SNP	C	C	A			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr10:87484184C>A	uc001kdl.1	-	11	1884	c.1783G>T	c.(1783-1785)GCC>TCC	p.A595S	GRID1_uc009xsu.1_RNA|GRID1_uc010qmf.1_Missense_Mutation_p.A166S	NM_017551	NP_060021	Q9ULK0	GRID1_HUMAN	glutamate receptor, ionotropic, delta 1	595	Cytoplasmic (Potential).					cell junction|integral to membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			ovary(5)|upper_aerodigestive_tract(2)|large_intestine(2)|central_nervous_system(1)	10					L-Glutamic Acid(DB00142)	CTGGGCTGGGCAGCACTCTGA	0.542			NA								Multiple Myeloma(13;0.14)			7	36					8.12818e-05	9.31233e-05	0.001984	1	0
OPN4	94233	broad.mit.edu	37	10	88415988	88415988	+	Missense_Mutation	SNP	G	G	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr10:88415988G>T	uc001kdq.2	+	2	448	c.221G>T	c.(220-222)GGC>GTC	p.G74V	OPN4_uc001kdp.2_Missense_Mutation_p.G74V|OPN4_uc010qmk.1_Missense_Mutation_p.G74V	NM_033282	NP_150598	Q9UHM6	OPN4_HUMAN	opsin 4 isoform 1	74	Helical; Name=1; (Potential).				phototransduction|protein-chromophore linkage|regulation of circadian rhythm|rhythmic process|visual perception	integral to membrane|plasma membrane	11-cis retinal binding|G-protein coupled photoreceptor activity			ovary(1)	1						TATACCCTGGGCACAGTGATC	0.622			NA											11	94					0.000673444	0.000748663	0.008291	1	0
CEP55	55165	broad.mit.edu	37	10	95276916	95276916	+	Nonsense_Mutation	SNP	G	G	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr10:95276916G>T	uc009xug.2	+	6	1086	c.904G>T	c.(904-906)GAG>TAG	p.E302*	CEP55_uc001kiq.3_Nonsense_Mutation_p.E302*	NM_001127182	NP_001120654	Q53EZ4	CEP55_HUMAN	centrosomal protein 55kDa	302	Potential.				cell division|mitosis	centriole|cleavage furrow|midbody					0		Colorectal(252;0.207)				GCATAAAACAGAGAAGATACA	0.368			NA											24	80					6.32553e-13	1.02528e-12	0.004656	1	0
AS3MT	57412	broad.mit.edu	37	10	104638606	104638606	+	Missense_Mutation	SNP	G	G	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr10:104638606G>T	uc001kwk.2	+	9	883	c.743G>T	c.(742-744)GGT>GTT	p.G248V	AS3MT_uc001kwj.2_Missense_Mutation_p.G250V|AS3MT_uc009xxh.2_Missense_Mutation_p.G248V	NM_020682	NP_065733	Q9HBK9	AS3MT_HUMAN	arsenic (+3 oxidation state) methyltransferase	248					arsonoacetate metabolic process|toxin metabolic process	cytosol	arsenite methyltransferase activity|methylarsonite methyltransferase activity				0		Colorectal(252;0.122)|all_hematologic(284;0.152)|Breast(234;0.198)		Epithelial(162;5.87e-09)|all cancers(201;1.58e-07)|BRCA - Breast invasive adenocarcinoma(275;0.223)		CTATTTTTAGGTGACTGTCGT	0.413			NA											10	33					7.48243e-07	9.64839e-07	0.006214	1	0
ATRNL1	26033	broad.mit.edu	37	10	117026348	117026348	+	Missense_Mutation	SNP	A	A	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr10:117026348A>T	uc001lcg.2	+	12	2233	c.1847A>T	c.(1846-1848)AAG>ATG	p.K616M		NM_207303	NP_997186	Q5VV63	ATRN1_HUMAN	attractin-like 1 precursor	616	PSI 1.|Kelch 6.|Extracellular (Potential).					integral to membrane	sugar binding			ovary(5)|lung(1)|central_nervous_system(1)	7		all_lung(145;0.0686)|Breast(234;0.0969)|Lung NSC(174;0.17)|Colorectal(252;0.234)		Epithelial(162;0.00031)|all cancers(201;0.000753)|LUSC - Lung squamous cell carcinoma(1;0.0515)|Lung(30;0.0827)		CCAAATTGCAAGGCTTTCAGA	0.338			NA											20	70					0	0	0.008871	0	0
GFRA1	2674	broad.mit.edu	37	10	118030531	118030531	+	Missense_Mutation	SNP	T	T	C			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr10:118030531T>C	uc001lcj.2	-	3	835	c.137A>G	c.(136-138)TAC>TGC	p.Y46C	GFRA1_uc001lci.2_Missense_Mutation_p.Y46C|GFRA1_uc009xyr.2_Missense_Mutation_p.Y46C	NM_005264	NP_005255	P56159	GFRA1_HUMAN	GDNF family receptor alpha 1 isoform a	46	1.				axon guidance	anchored to membrane|extrinsic to membrane|plasma membrane	glial cell-derived neurotrophic factor receptor activity			ovary(1)|pancreas(1)	2		Lung NSC(174;0.21)		all cancers(201;0.0337)		TAGCGTGCGGTACTTGGTGCT	0.642	Ovarian(128;329 1725 45498 46808 50759)		NA											7	67					0	0	0.00308	0	0
TACC2	10579	broad.mit.edu	37	10	123970146	123970146	+	Missense_Mutation	SNP	G	G	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr10:123970146G>T	uc001lfv.2	+	9	6566	c.6206G>T	c.(6205-6207)CGG>CTG	p.R2069L	TACC2_uc001lfw.2_Missense_Mutation_p.R215L|TACC2_uc009xzx.2_Missense_Mutation_p.R2024L|TACC2_uc010qtv.1_Missense_Mutation_p.R2073L|TACC2_uc001lfx.2_5'UTR|TACC2_uc001lfy.2_5'UTR|TACC2_uc001lfz.2_Missense_Mutation_p.R147L|TACC2_uc001lga.2_Missense_Mutation_p.R147L|TACC2_uc009xzy.2_Missense_Mutation_p.R147L|TACC2_uc001lgb.2_Missense_Mutation_p.R104L|TACC2_uc010qtw.1_Missense_Mutation_p.R164L	NM_206862	NP_996744	O95359	TACC2_HUMAN	transforming, acidic coiled-coil containing	2069						microtubule organizing center|nucleus	nuclear hormone receptor binding			ovary(4)|breast(3)|skin(2)|central_nervous_system(1)	10		all_neural(114;0.0656)|Lung NSC(174;0.136)|all_lung(145;0.17)|Breast(234;0.197)				GTGAACACACGGAGGAAGTCC	0.517			NA											18	83					1.67942e-08	2.35118e-08	0.006122	1	0
MUC2	4583	broad.mit.edu	37	11	1104128	1104128	+	Silent	SNP	C	C	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr11:1104128C>T	uc001lsx.1	+	52	15432	c.15405C>T	c.(15403-15405)AGC>AGT	p.S5135S		NM_002457	NP_002448	Q02817	MUC2_HUMAN	mucin 2 precursor	5135	CTCK.					inner mucus layer|outer mucus layer	protein binding			lung(1)|breast(1)	2		all_cancers(49;1.08e-07)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.191)		BRCA - Breast invasive adenocarcinoma(625;0.000207)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)	Pranlukast(DB01411)	TGGTCCTGAGCTGCCCCAATG	0.682			NA											4	24					0	0	0.009096	0	0
OR51E2	81285	broad.mit.edu	37	11	4703067	4703067	+	Missense_Mutation	SNP	C	C	A			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr11:4703067C>A	uc001lzk.2	-	2	1119	c.875G>T	c.(874-876)GGT>GTT	p.G292V		NM_030774	NP_110401	Q9H255	O51E2_HUMAN	olfactory receptor, family 51, subfamily E,	292	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			lung(3)|ovary(2)	5		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;3e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00476)|LUSC - Lung squamous cell carcinoma(625;0.2)		GGTTTTGGCACCATAGATGAT	0.507			NA											10	50					7.48243e-07	9.64839e-07	0.006214	1	0
OR2D2	120776	broad.mit.edu	37	11	6913354	6913354	+	Missense_Mutation	SNP	G	G	C			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr11:6913354G>C	uc010rau.1	-	1	378	c.378C>G	c.(376-378)ATC>ATG	p.I126M		NM_003700	NP_003691	Q9H210	OR2D2_HUMAN	olfactory receptor, family 2, subfamily D,	126	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|skin(1)	2		Medulloblastoma(188;0.0523)|all_neural(188;0.236)		Epithelial(150;4.68e-08)|BRCA - Breast invasive adenocarcinoma(625;0.129)		GAGGATTGCAGATTGCAACAT	0.493			NA											14	63					0	0	0.003163	0	0
SYT9	143425	broad.mit.edu	37	11	7324419	7324419	+	Missense_Mutation	SNP	C	C	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr11:7324419C>T	uc001mfe.2	+	2	532	c.295C>T	c.(295-297)CTT>TTT	p.L99F	SYT9_uc001mfd.2_RNA|SYT9_uc009yfi.2_RNA	NM_175733	NP_783860	Q86SS6	SYT9_HUMAN	synaptotagmin IX	99	Cytoplasmic (Potential).					cell junction|integral to membrane|synaptic vesicle membrane	metal ion binding|transporter activity			ovary(2)|large_intestine(1)	3				Epithelial(150;1.34e-07)|LUSC - Lung squamous cell carcinoma(625;0.0949)		CCAGGAGCCCCTTAACTACAT	0.547			NA											31	110					0	0	0.012213	0	0
NLRP10	338322	broad.mit.edu	37	11	7982838	7982838	+	Silent	SNP	G	G	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr11:7982838G>T	uc001mfv.1	-	2	338	c.321C>A	c.(319-321)CGC>CGA	p.R107R		NM_176821	NP_789791	Q86W26	NAL10_HUMAN	NLR family, pyrin domain containing 10	107							ATP binding			lung(4)|ovary(2)|pancreas(1)|kidney(1)|skin(1)	9				Epithelial(150;1.47e-07)|BRCA - Breast invasive adenocarcinoma(625;0.189)		CCTCTAGGCAGCGCACATGCT	0.512			NA											18	67					3.51602e-12	5.55757e-12	0.008871	1	0
KCNC1	3746	broad.mit.edu	37	11	17793517	17793517	+	Silent	SNP	G	G	A			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr11:17793517G>A	uc001mnk.3	+	2	931	c.876G>A	c.(874-876)GAG>GAA	p.E292E	KCNC1_uc009yhc.1_Silent_p.E292E	NM_004976	NP_004967	P48547	KCNC1_HUMAN	Shaw-related voltage-gated potassium channel	292	Helical; Name=Segment S3; (Potential).					voltage-gated potassium channel complex	voltage-gated potassium channel activity			upper_aerodigestive_tract(1)	1						TCTACCTGGAGGTGGGGCTGA	0.572			NA											13	92					0	0	0.001855	0	0
GAS2	2620	broad.mit.edu	37	11	22707280	22707280	+	Missense_Mutation	SNP	C	C	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr11:22707280C>T	uc009yie.2	+	3	518	c.212C>T	c.(211-213)GCA>GTA	p.A71V	GAS2_uc001mqm.2_Missense_Mutation_p.A71V|GAS2_uc001mqn.2_RNA|GAS2_uc001mqo.2_Missense_Mutation_p.A71V	NM_001143830	NP_001137302	O43903	GAS2_HUMAN	growth arrest-specific 2	71	CH.				cell cycle arrest|cellular component disassembly involved in apoptosis|regulation of cell shape	actin filament|cytosol|membrane				ovary(1)|skin(1)	2						TGTCAACTTGCAGAAACTATG	0.388			NA											10	51					0	0	0.001855	0	0
BBOX1	8424	broad.mit.edu	37	11	27147268	27147268	+	Missense_Mutation	SNP	G	G	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr11:27147268G>T	uc001mre.1	+	8	1272	c.904G>T	c.(904-906)GTG>TTG	p.V302L	BBOX1_uc009yih.1_Missense_Mutation_p.V302L|BBOX1_uc001mrg.1_Missense_Mutation_p.V302L	NM_003986	NP_003977	O75936	BODG_HUMAN	gamma-butyrobetaine dioxygenase	302					carnitine biosynthetic process	actin cytoskeleton|cytosol|intracellular membrane-bounded organelle	gamma-butyrobetaine dioxygenase activity|iron ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|zinc ion binding			ovary(1)	1					Succinic acid(DB00139)|Vitamin C(DB00126)	aatatttgatgtgcctgttga	0.144			NA											4	31					0.00909568	0.00960854	0.009096	1	0
QSER1	79832	broad.mit.edu	37	11	32953644	32953644	+	Missense_Mutation	SNP	G	G	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr11:32953644G>T	uc001mty.2	+	4	720	c.453G>T	c.(451-453)TTG>TTT	p.L151F	QSER1_uc001mtz.1_Missense_Mutation_p.L151F|QSER1_uc001mua.2_5'Flank	NM_001076786	NP_001070254	Q2KHR3	QSER1_HUMAN	glutamine and serine rich 1	151	Ser-rich.									ovary(3)|central_nervous_system(2)|skin(1)	6	Breast(20;0.158)					AATTTAGTTTGTTGCCTTCAG	0.458			NA											26	130					5.45024e-15	9.20903e-15	0.00333	1	0
CSTF3	1479	broad.mit.edu	37	11	33108609	33108609	+	Missense_Mutation	SNP	C	C	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr11:33108609C>T	uc001muh.2	-	18	1886	c.1720G>A	c.(1720-1722)GAA>AAA	p.E574K	TCP11L1_uc001muf.1_Intron	NM_001326	NP_001317	Q12996	CSTF3_HUMAN	cleavage stimulation factor subunit 3 isoform 1	574	Pro-rich.				mRNA cleavage|mRNA polyadenylation|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	nucleoplasm	protein binding|RNA binding				0						CTATCCACTTCATCTTTCAGA	0.438			NA											39	230					0	0	0.004289	0	0
OR4C46	119749	broad.mit.edu	37	11	51515712	51515712	+	Missense_Mutation	SNP	G	G	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr11:51515712G>T	uc010ric.1	+	1	431	c.431G>T	c.(430-432)GGA>GTA	p.G144V		NM_001004703	NP_001004703	A6NHA9	O4C46_HUMAN	olfactory receptor, family 4, subfamily C,	144	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						CTGCTAATGGGAGTGGTGTGG	0.453			NA											24	159					7.87624e-14	1.29643e-13	0.00278	1	0
TRIM48	79097	broad.mit.edu	37	11	55032685	55032685	+	Missense_Mutation	SNP	G	G	A			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr11:55032685G>A	uc010rid.1	+	2	440	c.354G>A	c.(352-354)ATG>ATA	p.M118I		NM_024114	NP_077019	Q8IWZ4	TRI48_HUMAN	tripartite motif-containing 48	102	B box-type.					intracellular	zinc ion binding				0						CAAAGAAGATGTTCTGTGAAG	0.532			NA											9	87					0	0	0.004482	0	0
OR5D13	390142	broad.mit.edu	37	11	55541127	55541127	+	Missense_Mutation	SNP	G	G	A			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr11:55541127G>A	uc010ril.1	+	1	214	c.214G>A	c.(214-216)GAC>AAC	p.D72N		NM_001001967	NP_001001967	Q8NGL4	OR5DD_HUMAN	olfactory receptor, family 5, subfamily D,	72	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|pancreas(1)|skin(1)	3		all_epithelial(135;0.196)				GTCCTTGACAGACTTCTGTTT	0.388			NA											27	109					0	0	0.004656	0	0
SPRYD5	84767	broad.mit.edu	37	11	55653015	55653015	+	Silent	SNP	C	C	A			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr11:55653015C>A	uc010rip.1	+	2	203	c.111C>A	c.(109-111)CCC>CCA	p.P37P	SPRYD5_uc010riq.1_5'Flank	NM_032681	NP_116070	Q9BSJ1	SPRY5_HUMAN	SPRY domain containing 5	37	RING-type.					intracellular	zinc ion binding				0		all_epithelial(135;0.226)				TTTGCCGGCCCTGTTTGTACC	0.507			NA											9	58					1.58986e-06	2.01341e-06	0.008291	1	0
OR10AG1	282770	broad.mit.edu	37	11	55735603	55735603	+	Missense_Mutation	SNP	G	G	C	rs150679428		TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr11:55735603G>C	uc010rit.1	-	1	337	c.337C>G	c.(337-339)CGC>GGC	p.R113G		NM_001005491	NP_001005491	Q8NH19	O10AG_HUMAN	olfactory receptor, family 10, subfamily AG,	113	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2	Esophageal squamous(21;0.0137)					GCCACGTAGCGGTCATAGGCC	0.428			NA											13	47					0	0	0.013537	0	0
OR10AG1	282770	broad.mit.edu	37	11	55735739	55735739	+	Silent	SNP	G	G	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr11:55735739G>T	uc010rit.1	-	1	201	c.201C>A	c.(199-201)ATC>ATA	p.I67I		NM_001005491	NP_001005491	Q8NH19	O10AG_HUMAN	olfactory receptor, family 10, subfamily AG,	67	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2	Esophageal squamous(21;0.0137)					TTGGGATAATGATTGTTACAT	0.348			NA											14	63					9.05144e-12	1.40972e-11	0.001855	1	0
OR8H2	390151	broad.mit.edu	37	11	55872682	55872682	+	Missense_Mutation	SNP	A	A	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr11:55872682A>T	uc010riy.1	+	1	164	c.164A>T	c.(163-165)CAG>CTG	p.Q55L		NM_001005200	NP_001005200	Q8N162	OR8H2_HUMAN	olfactory receptor, family 8, subfamily H,	55	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	Esophageal squamous(21;0.00693)					CTGGACCTCCAGCTTCACACT	0.423			NA								HNSCC(53;0.14)			61	278					0	0	0.01441	0	0
OR5J2	282775	broad.mit.edu	37	11	55944520	55944520	+	Missense_Mutation	SNP	G	G	A			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr11:55944520G>A	uc010rjb.1	+	1	427	c.427G>A	c.(427-429)GAG>AAG	p.E143K		NM_001005492	NP_001005492	Q8NH18	OR5J2_HUMAN	olfactory receptor, family 5, subfamily J,	143	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|large_intestine(1)|breast(1)|pancreas(1)	4	Esophageal squamous(21;0.00693)					AAAGTGTGTGGAGCTTGTCAC	0.458			NA											22	89					0	0	0.010504	0	0
OR9G4	283189	broad.mit.edu	37	11	56510406	56510406	+	Silent	SNP	G	G	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr11:56510406G>T	uc010rjo.1	-	1	882	c.882C>A	c.(880-882)ACC>ACA	p.T294T		NM_001005284	NP_001005284	Q8NGQ1	OR9G4_HUMAN	olfactory receptor, family 9, subfamily G,	294	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3						GGTTGATCACGGTGTAGAACA	0.438			NA											11	74					5.16669e-11	7.85484e-11	0.010729	1	0
OR9Q1	219956	broad.mit.edu	37	11	57947124	57947124	+	Missense_Mutation	SNP	G	G	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr11:57947124G>T	uc001nmj.2	+	3	524	c.208G>T	c.(208-210)GAC>TAC	p.D70Y		NM_001005212	NP_001005212	Q8NGQ5	OR9Q1_HUMAN	olfactory receptor, family 9, subfamily Q,	70	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		Breast(21;0.222)				CGCTTTCATGGACGTCTGCTA	0.498			NA											29	144					1.7881e-09	2.57697e-09	0.008361	1	0
OR4D6	219983	broad.mit.edu	37	11	59225093	59225093	+	Silent	SNP	C	C	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr11:59225093C>T	uc010rku.1	+	1	660	c.660C>T	c.(658-660)GTC>GTT	p.V220V		NM_001004708	NP_001004708	Q8NGJ1	OR4D6_HUMAN	olfactory receptor, family 4, subfamily D,	220	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						CCTACACTGTCATTCTGGTGA	0.567			NA											18	93					0	0	0.006122	0	0
OR4D11	219986	broad.mit.edu	37	11	59271238	59271238	+	Missense_Mutation	SNP	C	C	T	rs114830141	byFrequency	TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr11:59271238C>T	uc001noa.1	+	1	190	c.190C>T	c.(190-192)CGC>TGC	p.R64C		NM_001004706	NP_001004706	Q8NGI4	OR4DB_HUMAN	olfactory receptor, family 4, subfamily D,	64	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						CTTCCTGCTCCGCAATCTAGC	0.488			NA											52	217					0	0	0.01441	0	0
MRPL16	54948	broad.mit.edu	37	11	59573868	59573868	+	Silent	SNP	G	G	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr11:59573868G>T	uc001noh.2	-	4	922	c.708C>A	c.(706-708)ACC>ACA	p.T236T		NM_017840	NP_060310	Q9NX20	RM16_HUMAN	mitochondrial ribosomal protein L16 precursor	236							rRNA binding			central_nervous_system(1)	1						TCCCCTTGTGGGTCAAGTCAT	0.463			NA											44	178					3.4345e-17	6.1111e-17	0.011902	1	0
PLAC1L	219990	broad.mit.edu	37	11	59814444	59814444	+	Silent	SNP	T	T	A			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr11:59814444T>A	uc001nol.2	+	4	560	c.375T>A	c.(373-375)TCT>TCA	p.S125S		NM_173801	NP_776162	Q86WS3	PLACL_HUMAN	placenta-specific 1-like precursor	125						extracellular region				ovary(2)|skin(1)	3						CACCAGTTTCTACTGAGAATG	0.373			NA											22	93					0	0	0.00333	0	0
MS4A13	503497	broad.mit.edu	37	11	60310044	60310044	+	Missense_Mutation	SNP	C	C	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr11:60310044C>T	uc001nps.2	+	7	778	c.455C>T	c.(454-456)CCT>CTT	p.P152L	MS4A13_uc009ync.2_Missense_Mutation_p.P112L|MS4A13_uc009ynd.2_Missense_Mutation_p.P93L	NM_001012417	NP_001012417	Q5J8X5	M4A13_HUMAN	membrane-spanning 4-domains, subfamily A, member	152						integral to membrane					0						GAGAGCACTCCTTAAAAACCC	0.358			NA											3	8					0	0	0.004672	0	0
SYT7	9066	broad.mit.edu	37	11	61295600	61295600	+	Missense_Mutation	SNP	C	C	A			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr11:61295600C>A	uc001nrv.2	-	5	415	c.409G>T	c.(409-411)GGC>TGC	p.G137C	SYT7_uc009ynr.2_Missense_Mutation_p.G212C	NM_004200	NP_004191	O43581	SYT7_HUMAN	synaptotagmin VII	137	C2 1.|Cytoplasmic (Potential).					cell junction|integral to membrane|synaptic vesicle membrane	transporter activity			ovary(3)|pancreas(1)	4						TGGATCCGGCCCAGGTTCTCT	0.647			NA											24	66					6.36457e-07	8.2571e-07	0.003954	1	0
TMEM179B	374395	broad.mit.edu	37	11	62557391	62557391	+	Missense_Mutation	SNP	G	G	C			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr11:62557391G>C	uc001nvd.3	+	5	562	c.532G>C	c.(532-534)GTG>CTG	p.V178L		NM_199337	NP_955369	Q7Z7N9	T179B_HUMAN	transmembrane protein 179B	178	Helical; (Potential).					integral to membrane					0						ATTGTGGTGTGTGGTCTTGGT	0.557			NA											21	184					0	0	0.012319	0	0
NRXN2	9379	broad.mit.edu	37	11	64393933	64393933	+	Splice_Site	SNP	A	A	G			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr11:64393933A>G	uc001oap.2	-	5	1220	c.709_splice	c.e5+1	p.G237_splice	NRXN2_uc001oar.2_Splice_Site_p.G1283_splice|NRXN2_uc001oas.2_Intron|NRXN2_uc001oao.2_5'Flank|NRXN2_uc001oaq.2_Splice_Site_p.G950_splice	NM_138734	NP_620063	P58401	NRX2B_HUMAN	neurexin 2 isoform beta precursor						cell adhesion	integral to membrane				upper_aerodigestive_tract(2)|central_nervous_system(2)|skin(2)|ovary(2)|kidney(1)|pancreas(1)	10						CTGGTTAATTACCTTTGTCGA	0.433			NA											15	37					0	0	0.00245	0	0
MAP4K2	5871	broad.mit.edu	37	11	64564003	64564003	+	Missense_Mutation	SNP	C	C	A			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr11:64564003C>A	uc001obh.2	-	23	1687	c.1595G>T	c.(1594-1596)TGG>TTG	p.W532L	MAP4K2_uc001obg.2_5'Flank|MAP4K2_uc001obi.2_Missense_Mutation_p.W524L	NM_004579	NP_004570	Q12851	M4K2_HUMAN	mitogen-activated protein kinase kinase kinase	532	CNH.				activation of JUN kinase activity|immune response|positive regulation of JNK cascade|vesicle targeting	basolateral plasma membrane|Golgi membrane|soluble fraction	ATP binding|mitogen-activated protein kinase kinase kinase binding|protein serine/threonine kinase activity|small GTPase regulator activity			ovary(1)|pancreas(1)	2						GCAGTAGAGCCAGGAGCAGCG	0.657			NA											14	77					0.000151284	0.000171779	0.001855	1	0
POLA2	23649	broad.mit.edu	37	11	65043444	65043444	+	Missense_Mutation	SNP	C	C	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr11:65043444C>T	uc001odj.2	+	5	778	c.436C>T	c.(436-438)CTC>TTC	p.L146F	POLA2_uc009yqf.1_Missense_Mutation_p.L146F|POLA2_uc010rod.1_5'UTR	NM_002689	NP_002680	Q14181	DPOA2_HUMAN	DNA-directed DNA polymerase alpha 2	146	Pro/Ser/Thr-rich.				DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication	nucleoplasm	DNA binding				0					Dacarbazine(DB00851)	CCATCAGCTACTCTCACCGTC	0.483			NA											10	76					0	0	0.013537	0	0
C11orf82	220042	broad.mit.edu	37	11	82643414	82643414	+	Missense_Mutation	SNP	G	G	C			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr11:82643414G>C	uc001ozt.2	+	6	1278	c.1034G>C	c.(1033-1035)CGA>CCA	p.R345P	C11orf82_uc010rsr.1_Missense_Mutation_p.R44P|C11orf82_uc010rss.1_Missense_Mutation_p.R44P|C11orf82_uc009yvd.2_Intron	NM_145018	NP_659455	Q8IXT1	NOXIN_HUMAN	nitric oxide-inducible gene protein	345					apoptosis|cell cycle arrest	cytoplasm|nucleus				ovary(2)	2						TTGGAAATGCGAGAGCCCCTT	0.403			NA											38	115					0	0	0.004289	0	0
CREBZF	58487	broad.mit.edu	37	11	85375677	85375677	+	Silent	SNP	C	C	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr11:85375677C>T	uc001pas.2	-	1	506	c.243G>A	c.(241-243)GAG>GAA	p.E81E	CREBZF_uc010rtc.1_RNA|CREBZF_uc010rtd.1_RNA	NM_001039618	NP_001034707	Q9NS37	ZHANG_HUMAN	HCF-binding transcription factor Zhangfei	81					negative regulation of gene expression, epigenetic|negative regulation of transcription, DNA-dependent|regulation of sequence-specific DNA binding transcription factor activity|response to virus	nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1		Acute lymphoblastic leukemia(157;4.19e-06)|all_hematologic(158;0.0033)				CCTCCATCTCCTCGGGGGAGG	0.697	NSCLC(172;674 2044 9050 18334 41735)		NA											23	111					0	0	0.00333	0	0
NOX4	50507	broad.mit.edu	37	11	89166020	89166020	+	Silent	SNP	A	A	G			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr11:89166020A>G	uc001pct.2	-	7	719	c.480T>C	c.(478-480)CCT>CCC	p.P160P	NOX4_uc009yvr.2_Silent_p.P135P|NOX4_uc001pcu.2_Silent_p.P86P|NOX4_uc001pcw.2_Intron|NOX4_uc001pcx.2_Intron|NOX4_uc001pcv.2_Silent_p.P160P|NOX4_uc009yvo.2_RNA|NOX4_uc010rtu.1_5'UTR|NOX4_uc009yvp.2_Silent_p.P160P|NOX4_uc010rtv.1_Silent_p.P136P|NOX4_uc009yvq.2_Silent_p.P136P|NOX4_uc009yvs.1_RNA	NM_016931	NP_058627	Q9NPH5	NOX4_HUMAN	NADPH oxidase 4 isoform a	160	Ferric oxidoreductase.|Helical; (Potential).				cell aging|cell morphogenesis|inflammatory response|negative regulation of cell proliferation|superoxide anion generation	endoplasmic reticulum membrane|focal adhesion|integral to membrane|nucleus	electron carrier activity|flavin adenine dinucleotide binding|heme binding|NAD(P)H oxidase activity|nucleotide binding|oxygen sensor activity			ovary(1)|central_nervous_system(1)	2		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.011)				CTGTCAGGCCAGGAACTATAA	0.343			NA											4	16					0	0	0.009096	0	0
FOLH1B	219595	broad.mit.edu	37	11	89413826	89413826	+	Silent	SNP	A	A	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr11:89413826A>T	uc001pda.2	+	8	1024	c.498A>T	c.(496-498)GTA>GTT	p.V166V		NM_153696	NP_710163	Q9HBA9	FOH1B_HUMAN	folate hydrolase 1B	166					proteolysis	cytoplasm	dipeptidase activity|metal ion binding|metallopeptidase activity			ovary(3)|skin(2)|central_nervous_system(1)	6						ACAGCTTGGTATACAACCTAA	0.289			NA											7	27					0	0	0.006214	0	0
C11orf87	399947	broad.mit.edu	37	11	109294692	109294692	+	Silent	SNP	T	T	A			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr11:109294692T>A	uc001pkn.2	+	2	707	c.333T>A	c.(331-333)GGT>GGA	p.G111G	C11orf87_uc010rwb.1_5'Flank	NM_207645	NP_997528	Q6NUJ2	CK087_HUMAN	hypothetical protein LOC399947 precursor	111	Cytoplasmic (Potential).					integral to membrane				ovary(2)	2						GCAGCCGCGGTGGCGGGGGGC	0.657			NA											17	76					0	0	0.014323	0	0
DRD2	1813	broad.mit.edu	37	11	113281557	113281557	+	Nonsense_Mutation	SNP	G	G	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr11:113281557G>T	uc001pnz.2	-	7	1545	c.1224C>A	c.(1222-1224)TAC>TAA	p.Y408*	DRD2_uc010rwv.1_Nonsense_Mutation_p.Y407*|DRD2_uc001poa.3_Nonsense_Mutation_p.Y408*|DRD2_uc001pob.3_Nonsense_Mutation_p.Y379*	NM_000795	NP_000786	P14416	DRD2_HUMAN	dopamine receptor D2 isoform long	408	Extracellular (By similarity).				activation of phospholipase C activity by dopamine receptor signaling pathway|adenohypophysis development|adult walking behavior|arachidonic acid secretion|axonogenesis|behavioral response to cocaine|behavioral response to ethanol|branching morphogenesis of a nerve|cerebral cortex GABAergic interneuron migration|circadian regulation of gene expression|elevation of cytosolic calcium ion concentration involved in G-protein signaling coupled to IP3 second messenger|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|intracellular protein kinase cascade|negative regulation of blood pressure|negative regulation of calcium ion transport via voltage-gated calcium channel activity|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of dopamine receptor signaling pathway|negative regulation of protein kinase B signaling cascade|negative regulation of protein secretion|negative regulation of synaptic transmission, glutamatergic|neurological system process involved in regulation of systemic arterial blood pressure|peristalsis|phosphatidylinositol metabolic process|positive regulation of dopamine uptake|positive regulation of growth hormone secretion|positive regulation of neuroblast proliferation|prepulse inhibition|protein localization|regulation of heart rate|regulation of long-term neuronal synaptic plasticity|regulation of potassium ion transport|regulation of sodium ion transport|regulation of synaptic transmission, GABAergic|release of sequestered calcium ion into cytosol|response to amphetamine|response to drug|response to histamine|response to morphine|sensory perception of smell|synapse assembly|temperature homeostasis|visual learning	integral to plasma membrane	dopamine D2 receptor activity|dopamine receptor activity, coupled via Gi/Go|drug binding|potassium channel regulator activity|protein binding			pancreas(1)|skin(1)	2		all_cancers(61;3.91e-16)|all_epithelial(67;2.95e-09)|Melanoma(852;1.46e-05)|all_hematologic(158;0.00014)|Acute lymphoblastic leukemia(157;0.000977)|Breast(348;0.0101)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)|Prostate(24;0.0494)		BRCA - Breast invasive adenocarcinoma(274;5.77e-06)|Epithelial(105;6.66e-05)|all cancers(92;0.000307)|OV - Ovarian serous cystadenocarcinoma(223;0.216)	Acetophenazine(DB01063)|Amantadine(DB00915)|Apomorphine(DB00714)|Aripiprazole(DB01238)|Bromocriptine(DB01200)|Buspirone(DB00490)|Cabergoline(DB00248)|Carphenazine(DB01038)|Chlorpromazine(DB00477)|Chlorprothixene(DB01239)|Cinnarizine(DB00568)|Clozapine(DB00363)|Domperidone(DB01184)|Droperidol(DB00450)|Ergotamine(DB00696)|Flupenthixol(DB00875)|Fluphenazine(DB00623)|Fluspirilene(DB04842)|Haloperidol(DB00502)|Levodopa(DB01235)|Lisuride(DB00589)|Loxapine(DB00408)|Mesoridazine(DB00933)|Metoclopramide(DB01233)|Minaprine(DB00805)|Molindone(DB01618)|Olanzapine(DB00334)|Paliperidone(DB01267)|Pergolide(DB01186)|Perphenazine(DB00850)|Pimozide(DB01100)|Pramipexole(DB00413)|Prochlorperazine(DB00433)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Quetiapine(DB01224)|Remoxipride(DB00409)|Risperidone(DB00734)|Ropinirole(DB00268)|Sertindole(DB06144)|Sulpiride(DB00391)|Thiethylperazine(DB00372)|Thioridazine(DB00679)|Tranylcypromine(DB00752)|Trifluoperazine(DB00831)|Triflupromazine(DB00508)|Ziprasidone(DB00246)|Zuclopenthixol(DB01624)	TGAAGGCGCTGTACAGGACAG	0.557			NA											14	94					4.36969e-10	6.41358e-10	0.001855	1	0
FAM55A	120400	broad.mit.edu	37	11	114392778	114392778	+	Missense_Mutation	SNP	A	A	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr11:114392778A>T	uc001ppa.2	-	6	1547	c.1130T>A	c.(1129-1131)ATG>AAG	p.M377K	FAM55A_uc010rxd.1_Missense_Mutation_p.M226K	NM_152315	NP_689528	Q8N323	FA55A_HUMAN	hypothetical protein LOC120400	519						extracellular region					0		all_cancers(61;8.53e-16)|all_epithelial(67;1.71e-08)|all_hematologic(158;3.05e-05)|Melanoma(852;0.000902)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0194)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)|Prostate(24;0.0906)		BRCA - Breast invasive adenocarcinoma(274;3.02e-06)|Epithelial(105;0.000144)|all cancers(92;0.00106)		TGCAATGGTCATGTCCCAGGC	0.398			NA											22	60					0	0	0.014323	0	0
OR6M1	390261	broad.mit.edu	37	11	123676321	123676321	+	Missense_Mutation	SNP	G	G	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr11:123676321G>T	uc010rzz.1	-	1	737	c.737C>A	c.(736-738)TCC>TAC	p.S246Y		NM_001005325	NP_001005325	Q8NGM8	OR6M1_HUMAN	olfactory receptor, family 6, subfamily M,	246	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2		Breast(109;0.0109)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.028)		GTGGGCAATGGAGACAACAGT	0.512			NA											13	41					2.27111e-07	2.99523e-07	0.013537	1	0
ADAMTS8	11095	broad.mit.edu	37	11	130275652	130275652	+	Missense_Mutation	SNP	G	G	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr11:130275652G>T	uc001qgg.3	-	9	2829	c.2471C>A	c.(2470-2472)ACC>AAC	p.T824N	ADAMTS8_uc001qgf.2_Missense_Mutation_p.T305N	NM_007037	NP_008968	Q9UP79	ATS8_HUMAN	ADAM metallopeptidase with thrombospondin type 1	824	Spacer.				negative regulation of cell proliferation|proteolysis	proteinaceous extracellular matrix	heparin binding|integrin binding|low affinity phosphate transmembrane transporter activity|metalloendopeptidase activity|zinc ion binding			central_nervous_system(1)	1	all_hematologic(175;0.0429)	Lung NSC(97;0.000601)|Breast(109;0.000962)|all_lung(97;0.00125)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.039)|Lung(977;0.213)		GATGTTGGTGGTTGCTCTCTC	0.572			NA											47	191					2.64894e-19	4.82107e-19	0.01441	1	0
ADAMTS8	11095	broad.mit.edu	37	11	130278466	130278466	+	Silent	SNP	G	G	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr11:130278466G>T	uc001qgg.3	-	8	2350	c.1992C>A	c.(1990-1992)GCC>GCA	p.A664A	ADAMTS8_uc001qgf.2_Silent_p.A145A	NM_007037	NP_008968	Q9UP79	ATS8_HUMAN	ADAM metallopeptidase with thrombospondin type 1	664	Cys-rich.				negative regulation of cell proliferation|proteolysis	proteinaceous extracellular matrix	heparin binding|integrin binding|low affinity phosphate transmembrane transporter activity|metalloendopeptidase activity|zinc ion binding			central_nervous_system(1)	1	all_hematologic(175;0.0429)	Lung NSC(97;0.000601)|Breast(109;0.000962)|all_lung(97;0.00125)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.039)|Lung(977;0.213)		GGTCACAGCCGGCCTTGACAC	0.627			NA											18	117					6.94344e-10	1.01212e-09	0.006122	1	0
IGSF9B	22997	broad.mit.edu	37	11	133799663	133799663	+	Missense_Mutation	SNP	C	C	A			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr11:133799663C>A	uc001qgx.3	-	12	1765	c.1534G>T	c.(1534-1536)GCC>TCC	p.A512S	IGSF9B_uc001qgy.1_Missense_Mutation_p.A354S	NM_014987	NP_055802	Q9UPX0	TUTLB_HUMAN	immunoglobulin superfamily, member 9B	512	Extracellular (Potential).|Fibronectin type-III 1.					integral to membrane|plasma membrane					0	all_hematologic(175;0.127)	all_cancers(12;1.58e-21)|all_epithelial(12;5.17e-16)|all_lung(97;1.6e-05)|Lung NSC(97;3.86e-05)|Breast(109;0.000126)|Medulloblastoma(222;0.0245)|all_neural(223;0.0505)|Esophageal squamous(93;0.0559)		Epithelial(10;7.19e-10)|BRCA - Breast invasive adenocarcinoma(10;9.69e-09)|all cancers(11;1.23e-08)|OV - Ovarian serous cystadenocarcinoma(99;0.00328)|Lung(977;0.221)		CTGCCCGGGGCATGGGGGCTG	0.592			NA											14	49					3.27435e-08	4.48551e-08	0.00245	1	0
KCNA5	3741	broad.mit.edu	37	12	5154561	5154561	+	Silent	SNP	C	C	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr12:5154561C>T	uc001qni.2	+	1	1477	c.1248C>T	c.(1246-1248)CAC>CAT	p.H416H		NM_002234	NP_002225	P22460	KCNA5_HUMAN	potassium voltage-gated channel, shaker-related	416	Helical; Voltage-sensor; Name=Segment S4; (Potential).					Golgi apparatus|voltage-gated potassium channel complex	delayed rectifier potassium channel activity			ovary(2)|breast(2)	4						TCTCCCGCCACTCCAAGGGGC	0.627			NA											6	31					0	0	0.001984	0	0
VWF	7450	broad.mit.edu	37	12	6181546	6181546	+	Nonsense_Mutation	SNP	C	C	A			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr12:6181546C>A	uc001qnn.1	-	9	1310	c.1060G>T	c.(1060-1062)GGA>TGA	p.G354*	VWF_uc010set.1_Nonsense_Mutation_p.G354*	NM_000552	NP_000543	P04275	VWF_HUMAN	von Willebrand factor preproprotein	354					blood coagulation, intrinsic pathway|cell-substrate adhesion|platelet activation|platelet degranulation|protein homooligomerization	endoplasmic reticulum|platelet alpha granule lumen|proteinaceous extracellular matrix|Weibel-Palade body	chaperone binding|collagen binding|glycoprotein binding|immunoglobulin binding|integrin binding|protease binding|protein homodimerization activity|protein N-terminus binding			skin(4)|ovary(3)|pancreas(2)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|breast(1)	12					Antihemophilic Factor(DB00025)	TAGCGCTTTCCGGAATGCACG	0.632			NA											17	87					5.3912e-06	6.59155e-06	0.006122	1	0
CLEC6A	93978	broad.mit.edu	37	12	8628803	8628804	+	Missense_Mutation	DNP	GG	GG	TT			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr12:8628803_8628804GG>TT	uc001qum.1	+	5	569_570	c.452_453GG>TT	c.(451-453)TGG>TTT	p.W151F		NM_001007033	NP_001007034	Q6EIG7	CLC6A_HUMAN	dectin-2	151	Extracellular (Potential).|C-type lectin.				defense response to fungus|innate immune response|positive regulation of cytokine secretion|positive regulation of I-kappaB kinase/NF-kappaB cascade	integral to membrane	sugar binding			breast(1)	1	Lung SC(5;0.184)					aattggcaatggattgataaga	0.119			NA											14	65					0	0	0.004672	0	0
DDX12	440081	broad.mit.edu	37	12	9573176	9573176	+	Silent	SNP	G	G	A			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr12:9573176G>A	uc010sgs.1	-	21	2332	c.2137C>T	c.(2137-2139)CTG>TTG	p.L713L	DDX12_uc001qvx.3_5'Flank|DDX12_uc001qvy.1_5'Flank	NM_004400	NP_004391			DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 12												0						ACCTGGCGCAGGTACTCGTAG	0.577			NA											4	34					0	0	0.009096	0	0
GRIN2B	2904	broad.mit.edu	37	12	13769510	13769510	+	Missense_Mutation	SNP	C	C	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr12:13769510C>T	uc001rbt.2	-	5	1386	c.1207G>A	c.(1207-1209)GAT>AAT	p.D403N		NM_000834	NP_000825	Q13224	NMDE2_HUMAN	N-methyl-D-aspartate receptor subunit 2B	403	Extracellular (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	glycine binding|N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			central_nervous_system(4)|ovary(3)|skin(3)|lung(2)	12					Felbamate(DB00949)|Haloperidol(DB00502)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	AGATGGTCATCCTCCTGCTCT	0.527			NA											15	80					0	0	0.003163	0	0
KRAS	3845	broad.mit.edu	37	12	25398285	25398285	+	Missense_Mutation	SNP	C	C	G	rs121913530		TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr12:25398285C>G	uc001rgp.1	-	2	215	c.34G>C	c.(34-36)GGT>CGT	p.G12R	KRAS_uc001rgq.1_Missense_Mutation_p.G12R|KRAS_uc001rgr.2_RNA	NM_033360	NP_203524	P01116	RASK_HUMAN	c-K-ras2 protein isoform a precursor	12	GTP.		G -> D (in pancreatic carcinoma, GASC and lung carcinoma; somatic mutation).|G -> R (in lung cancer and bladder cancer; somatic mutation).|G -> S (in lung carcinoma and GASC; somatic mutation).|G -> A (in a colorectal cancer sample; somatic mutation).|G -> C (in lung carcinoma; somatic mutation).|G -> V (in lung carcinoma, pancreatic carcinoma, colon cancer and GASC; somatic mutation).		activation of MAPKK activity|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	plasma membrane	GTP binding|GTPase activity|protein binding	p.G12D(7175)|p.G12V(4780)|p.G12C(2482)|p.G12A(1180)|p.G12S(1119)|p.G12R(691)|p.G12?(50)|p.G12F(34)|p.G12G(6)|p.G12N(6)|p.G12L(5)|p.G12I(4)|p.G12_G13insG(4)|p.G12E(3)|p.G12W(3)|p.A11_G12insGA(2)|p.G12Y(2)|p.G12fs*3(1)		large_intestine(12391)|pancreas(3285)|lung(2847)|biliary_tract(521)|ovary(443)|endometrium(339)|haematopoietic_and_lymphoid_tissue(318)|stomach(203)|thyroid(149)|prostate(85)|soft_tissue(77)|small_intestine(62)|upper_aerodigestive_tract(59)|cervix(49)|urinary_tract(48)|skin(38)|liver(31)|breast(28)|testis(17)|oesophagus(15)|central_nervous_system(9)|peritoneum(6)|salivary_gland(6)|kidney(5)|gastrointestinal_tract_(site_indeterminate)(5)|thymus(5)|eye(4)|autonomic_ganglia(2)|bone(2)|genital_tract(1)|penis(1)|adrenal_gland(1)	21052	all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)		OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)			CCTACGCCACCAGCTCCAACT	0.348	Pancreas(8;6 143 191 305 2070 2426 4376 10944 11745 26467 38091 50869)	G12C(UMUC3_URINARY_TRACT)|G12R(CAL62_THYROID)|G12C(CALU1_LUNG)|G12C(NCIH2030_LUNG)|G12C(LU99_LUNG)|G12C(NCIH1792_LUNG)|G12R(KP2_PANCREAS)|G12C(KHM1B_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12C(NCIH2122_LUNG)|G12C(NCIH358_LUNG)|G12R(PSN1_PANCREAS)|G12C(KYSE410_OESOPHAGUS)|G12S(A549_LUNG)|G12R(HUPT3_PANCREAS)|G12R(TCCPAN2_PANCREAS)|G12C(HCC44_LUNG)|G12S(KMS20_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12C(SW1463_LARGE_INTESTINE)|G12C(NCIH23_LUNG)|G12C(LU65_LUNG)|G12C(NCIH1373_LUNG)|G12C(MIAPACA2_PANCREAS)|G12R(HS274T_BREAST)|G12S(LS123_LARGE_INTESTINE)|G12C(SW1573_LUNG)|G12C(SW837_LARGE_INTESTINE)|G12C(OV56_OVARY)|G12C(IALM_LUNG)	119	Mis		pancreatic|colorectal|lung|thyroid|AML|others				Cardiofaciocutaneous_syndrome|Noonan_syndrome	TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)			3	10					0	0	0.004672	0	0
ITPR2	3709	broad.mit.edu	37	12	26753039	26753039	+	Missense_Mutation	SNP	C	C	G			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr12:26753039C>G	uc001rhg.2	-	29	4099	c.3682G>C	c.(3682-3684)GAT>CAT	p.D1228H		NM_002223	NP_002214	Q14571	ITPR2_HUMAN	inositol 1,4,5-triphosphate receptor, type 2	1228	Cytoplasmic (Potential).				activation of phospholipase C activity|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	integral to membrane|plasma membrane enriched fraction|platelet dense tubular network membrane|sarcoplasmic reticulum membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity			kidney(6)|ovary(4)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	14	Colorectal(261;0.0847)					ATCTTTTCATCATTCTGTAAG	0.343			NA											3	19					0	0	0.004672	0	0
Unknown	0	broad.mit.edu	37	12	31311920	31311920	+	Silent	SNP	C	C	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr12:31311920C>T	uc010sjy.1	-	5	510	c.510G>A	c.(508-510)TCG>TCA	p.S170S						RecName: Full=Ovostatin homolog 1; Flags: Precursor;												NA						TCAGTTGGAACGAGAGTTGGG	0.333			NA											13	178					0	0	0.001855	0	0
KIAA0748	9840	broad.mit.edu	37	12	55356595	55356595	+	Missense_Mutation	SNP	A	A	G			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr12:55356595A>G	uc001sgn.3	-	9	1197	c.1087T>C	c.(1087-1089)TGC>CGC	p.C363R	KIAA0748_uc001sgl.3_Missense_Mutation_p.C225R|KIAA0748_uc001sgm.3_Missense_Mutation_p.C110R|KIAA0748_uc010spb.1_Missense_Mutation_p.C110R|KIAA0748_uc010spc.1_Missense_Mutation_p.C225R|KIAA0748_uc010spd.1_Missense_Mutation_p.C363R|KIAA0748_uc001sgo.3_RNA	NM_001098815	NP_001092285	A2RU30	K0748_HUMAN	hypothetical protein LOC9840	363										ovary(1)|central_nervous_system(1)	2						TCTTCACAGCAGAAGACACAT	0.527			NA											13	40					0	0	0.001855	0	0
E2F7	144455	broad.mit.edu	37	12	77421680	77421680	+	Missense_Mutation	SNP	C	C	A			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr12:77421680C>A	uc001sym.3	-	11	2359	c.2123G>T	c.(2122-2124)TGT>TTT	p.C708F	E2F7_uc009zse.2_Missense_Mutation_p.C195F	NM_203394	NP_976328	Q96AV8	E2F7_HUMAN	E2F transcription factor 7	708					cell cycle	transcription factor complex	DNA binding|identical protein binding			upper_aerodigestive_tract(1)|ovary(1)|kidney(1)	3						AGACTGCACACAAAGATATTG	0.403			NA											13	38					0.000308642	0.000347359	0.003163	1	0
PLXNC1	10154	broad.mit.edu	37	12	94694764	94694764	+	Silent	SNP	C	C	T	rs113780946	by1000genomes	TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr12:94694764C>T	uc001tdc.2	+	28	4566	c.4317C>T	c.(4315-4317)GAC>GAT	p.D1439D	PLXNC1_uc010sut.1_Silent_p.D486D|PLXNC1_uc009zsv.2_Silent_p.D178D	NM_005761	NP_005752	O60486	PLXC1_HUMAN	plexin C1 precursor	1439	Cytoplasmic (Potential).				axon guidance|cell adhesion	integral to membrane|intracellular|plasma membrane	receptor activity|receptor binding			ovary(2)|central_nervous_system(1)	3						CACATATAGACGGCTGTTTGT	0.443			NA											16	56					0	0	0.004007	0	0
C12orf63	374467	broad.mit.edu	37	12	97137624	97137624	+	Missense_Mutation	SNP	C	C	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr12:97137624C>T	uc001tet.1	+	21	2846	c.2768C>T	c.(2767-2769)TCT>TTT	p.S923F		NM_198520	NP_940922	Q6ZTY8	CL063_HUMAN	hypothetical protein LOC374467	923										skin(6)|ovary(1)	7						TTCAAGGAATCTCCCTCTTCA	0.398			NA											3	27					0	0	0.004672	0	0
C12orf51	283450	broad.mit.edu	37	12	112669411	112669411	+	Missense_Mutation	SNP	T	T	C			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr12:112669411T>C	uc009zwc.2	-	32	4858	c.4840A>G	c.(4840-4842)ATC>GTC	p.I1614V		NM_001109662	NP_001103132			chromosome 12 open reading frame 51											ovary(1)|lung(1)	2						TCTGGGTTGATAGACTCTACA	0.532			NA											16	58					0	0	0.00499	0	0
FZD10	11211	broad.mit.edu	37	12	130648510	130648510	+	Silent	SNP	G	G	A			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr12:130648510G>A	uc001uii.2	+	1	1479	c.1023G>A	c.(1021-1023)AAG>AAA	p.K341K	uc001uig.1_5'Flank|uc001uih.1_5'Flank	NM_007197	NP_009128	Q9ULW2	FZD10_HUMAN	frizzled 10 precursor	341	Cytoplasmic (Potential).				brain development|canonical Wnt receptor signaling pathway|cellular response to retinoic acid|embryo development|gonad development|negative regulation of Rho GTPase activity|neuron differentiation|non-canonical Wnt receptor signaling pathway|positive regulation of JUN kinase activity|positive regulation of Rac GTPase activity|regulation of actin cytoskeleton organization|vasculature development	cell projection|cell surface|cytoplasm|integral to plasma membrane	G-protein coupled receptor activity|PDZ domain binding|Wnt receptor activity|Wnt-protein binding			lung(3)|breast(1)|central_nervous_system(1)	5	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.3e-06)|Epithelial(86;1.66e-05)|all cancers(50;5.18e-05)		CCGGCAAGAAGTGGGGCCACG	0.647			NA											8	38					0	0	0.00308	0	0
ZMYM2	7750	broad.mit.edu	37	13	20656961	20656961	+	Missense_Mutation	SNP	G	G	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr13:20656961G>T	uc001umr.2	+	24	3907	c.3609G>T	c.(3607-3609)AGG>AGT	p.R1203S	ZMYM2_uc001ums.2_Missense_Mutation_p.R1203S|ZMYM2_uc001umt.2_Missense_Mutation_p.R1203S|ZMYM2_uc001umv.2_Missense_Mutation_p.R583S|ZMYM2_uc001umw.2_Missense_Mutation_p.R656S	NM_003453	NP_003444	Q9UBW7	ZMYM2_HUMAN	zinc finger protein 198	1203					regulation of transcription, DNA-dependent|transcription, DNA-dependent	PML body	ubiquitin conjugating enzyme binding|zinc ion binding			lung(3)|ovary(2)|prostate(1)	6		all_cancers(29;8.65e-21)|all_epithelial(30;1.04e-18)|all_lung(29;6.75e-18)|Lung SC(185;0.0262)|Ovarian(182;0.162)		all cancers(112;0.000148)|Epithelial(112;0.000249)|OV - Ovarian serous cystadenocarcinoma(117;0.00816)|Lung(94;0.0173)|LUSC - Lung squamous cell carcinoma(192;0.0856)		ATCTCTGGAGGATAAAACAAC	0.313			NA											7	27					0.00198382	0.00216386	0.001984	1	0
CDK8	1024	broad.mit.edu	37	13	26975623	26975623	+	Missense_Mutation	SNP	G	G	C			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr13:26975623G>C	uc001uqr.1	+	12	1157	c.1131G>C	c.(1129-1131)CAG>CAC	p.Q377H	CDK8_uc001uqs.1_Missense_Mutation_p.Q376H|CDK8_uc001uqt.1_Missense_Mutation_p.Q204H	NM_001260	NP_001251	P49336	CDK8_HUMAN	cyclin-dependent kinase 8	377	Poly-Gln.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	mediator complex	ATP binding|cyclin-dependent protein kinase activity|protein binding|RNA polymerase II carboxy-terminal domain kinase activity			lung(2)|large_intestine(1)|ovary(1)|skin(1)	5	Colorectal(5;0.000442)	Lung SC(185;0.0156)|Breast(139;0.147)		all cancers(112;0.0384)|Epithelial(112;0.142)|OV - Ovarian serous cystadenocarcinoma(117;0.188)		AGCAGCAGCAGGGCAATAACC	0.468			NA											9	30					0	0	0.004482	0	0
CDX2	1045	broad.mit.edu	37	13	28542718	28542718	+	Silent	SNP	G	G	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr13:28542718G>T	uc001urv.2	-	1	600	c.426C>A	c.(424-426)CCC>CCA	p.P142P		NM_001265	NP_001256	Q99626	CDX2_HUMAN	caudal type homeobox 2	142					organ morphogenesis|transcription from RNA polymerase II promoter		sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			lung(1)	1	all_cancers(110;0.191)|all_hematologic(3;0.0447)|Acute lymphoblastic leukemia(6;0.155)	Lung SC(185;0.0156)	Colorectal(13;0.000157)|READ - Rectum adenocarcinoma(15;0.105)	GBM - Glioblastoma multiforme(144;0.0407)|all cancers(112;0.0491)|OV - Ovarian serous cystadenocarcinoma(117;0.199)		CAGGAGGGCCGGGGTTGAGCG	0.607			NA	T	ETV6	AML								6	6					5.9392e-07	7.72096e-07	0.001168	1	0
MTUS2	23281	broad.mit.edu	37	13	29608247	29608247	+	Missense_Mutation	SNP	A	A	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr13:29608247A>T	uc001usl.3	+	2	2519	c.2461A>T	c.(2461-2463)AGT>TGT	p.S821C		NM_001033602	NP_001028774	Q5JR59	MTUS2_HUMAN	hypothetical protein LOC23281 isoform a	811	Sufficient for interaction with KIF2C.|Localization to the growing distal tip of microtubules.|Mediates interaction with MAPRE1.					cytoplasm|microtubule	microtubule binding|protein homodimerization activity				0						CAGTCTCTACAGTTCCGATCC	0.453			NA											10	42					0	0	0.006214	0	0
HNRNPA1L2	144983	broad.mit.edu	37	13	53216956	53216956	+	Missense_Mutation	SNP	G	G	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr13:53216956G>T	uc001vgx.1	+	7	1402	c.329G>T	c.(328-330)GGT>GTT	p.G110V	HNRNPA1L2_uc001vgy.1_Missense_Mutation_p.G110V|HNRNPA1L2_uc001vgz.1_Missense_Mutation_p.G110V	NM_001011724	NP_001011724	Q32P51	RA1L2_HUMAN	heterogeneous nuclear ribonucleoprotein A1-like	110	Globular B domain.|RRM 2.				mRNA processing|mRNA transport|RNA splicing	cytoplasm|spliceosomal complex	nucleotide binding|RNA binding				0						ATATTTGTTGGTGGCATTAAA	0.408			NA											3	26					0.004672	0.00501021	0.004672	1	0
OLFM4	10562	broad.mit.edu	37	13	53624469	53624469	+	Missense_Mutation	SNP	A	A	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr13:53624469A>T	uc001vhl.2	+	5	1096	c.1096A>T	c.(1096-1098)AAT>TAT	p.N366Y	OLFM4_uc001vhk.1_3'UTR	NM_006418	NP_006409	Q6UX06	OLFM4_HUMAN	olfactomedin 4 precursor	366	Olfactomedin-like.				cell adhesion	extracellular space				skin(1)	1		Breast(56;0.000776)|Lung NSC(96;0.000814)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;3.13e-08)		AACTCTCCCTAATGCTGCCTA	0.403			NA											30	140					0	0	0.008361	0	0
PCDH17	27253	broad.mit.edu	37	13	58207657	58207657	+	Missense_Mutation	SNP	T	T	A			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr13:58207657T>A	uc001vhq.1	+	1	1869	c.977T>A	c.(976-978)CTG>CAG	p.L326Q	PCDH17_uc010aec.1_Missense_Mutation_p.L326Q	NM_001040429	NP_001035519	O14917	PCD17_HUMAN	protocadherin 17 precursor	326	Extracellular (Potential).|Cadherin 3.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			ovary(3)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	7		Lung NSC(96;0.027)|Prostate(109;0.0453)|Breast(118;0.128)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;1.06e-05)		GCCCGAGACCTGGGGCCTAAC	0.597	Melanoma(72;952 1291 1619 12849 33676)		NA											11	71					0	0	0.008291	0	0
NALCN	259232	broad.mit.edu	37	13	101726022	101726022	+	Missense_Mutation	SNP	T	T	C			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr13:101726022T>C	uc001vox.1	-	37	4300	c.4111A>G	c.(4111-4113)AAT>GAT	p.N1371D		NM_052867	NP_443099	Q8IZF0	NALCN_HUMAN	voltage gated channel like 1	1371	Extracellular (Potential).					integral to membrane	sodium channel activity|voltage-gated ion channel activity			ovary(8)|breast(4)|skin(2)|pancreas(1)|central_nervous_system(1)	16	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					GAAGAAAAATTTGCATGCCTA	0.358			NA											3	33					0	0	0.004672	0	0
SLC10A2	6555	broad.mit.edu	37	13	103710636	103710636	+	Missense_Mutation	SNP	G	G	C			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr13:103710636G>C	uc001vpy.3	-	2	1071	c.474C>G	c.(472-474)ATC>ATG	p.I158M		NM_000452	NP_000443	Q12908	NTCP2_HUMAN	solute carrier family 10 (sodium/bile acid	158	Helical; (Potential).				bile acid metabolic process|organic anion transport	integral to plasma membrane	bile acid:sodium symporter activity			ovary(3)|skin(1)	4	all_neural(89;0.0662)|Medulloblastoma(90;0.163)|Lung SC(71;0.211)					AGGGAATTACGATGCTCCCAG	0.502			NA											15	87					0	0	0.00245	0	0
MYO16	23026	broad.mit.edu	37	13	109707814	109707814	+	Missense_Mutation	SNP	C	C	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr13:109707814C>T	uc001vqt.1	+	27	3266	c.3140C>T	c.(3139-3141)TCA>TTA	p.S1047L	MYO16_uc010agk.1_Missense_Mutation_p.S1069L|MYO16_uc001vqu.1_Missense_Mutation_p.S847L|MYO16_uc010tjh.1_Missense_Mutation_p.S559L	NM_015011	NP_055826	Q9Y6X6	MYO16_HUMAN	myosin heavy chain Myr 8	1047	Myosin head-like 2.				cerebellum development|negative regulation of cell proliferation|negative regulation of S phase of mitotic cell cycle	myosin complex|nucleoplasm|perinuclear region of cytoplasm|plasma membrane	actin filament binding|ATP binding|motor activity			ovary(6)|large_intestine(1)|kidney(1)|breast(1)|central_nervous_system(1)	10	all_lung(23;0.000332)|all_neural(89;0.00294)|Medulloblastoma(90;0.00596)|Lung NSC(43;0.00751)|Lung SC(71;0.104)		BRCA - Breast invasive adenocarcinoma(86;0.19)|all cancers(43;0.201)			CCCAATAACTCAAAGCTGCCA	0.403			NA											15	53					0	0	0.00245	0	0
OR4Q3	441669	broad.mit.edu	37	14	20216098	20216098	+	Missense_Mutation	SNP	G	G	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr14:20216098G>T	uc010tkt.1	+	1	512	c.512G>T	c.(511-513)GGG>GTG	p.G171V		NM_172194	NP_751944	Q8NH05	OR4Q3_HUMAN	olfactory receptor, family 4, subfamily Q,	171	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(3)	3	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		CCTTTCTGTGGGCCCAATGAA	0.512			NA											8	104					0.00621372	0.00663005	0.006214	1	0
OR4E2	26686	broad.mit.edu	37	14	22133904	22133904	+	Missense_Mutation	SNP	G	G	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr14:22133904G>T	uc010tmd.1	+	1	608	c.608G>T	c.(607-609)AGT>ATT	p.S203I		NM_001001912	NP_001001912	Q8NGC2	OR4E2_HUMAN	olfactory receptor, family 4, subfamily E,	203	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|pancreas(1)|skin(1)	4	all_cancers(95;0.00113)	Acute lymphoblastic leukemia(2;0.0279)		GBM - Glioblastoma multiforme(265;0.0137)		GTGACCAATAGTGGAACCATC	0.493			NA											22	60					4.35082e-09	6.20016e-09	0.010504	1	0
AKAP6	9472	broad.mit.edu	37	14	33291625	33291625	+	Missense_Mutation	SNP	A	A	G			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr14:33291625A>G	uc001wrq.2	+	13	4776	c.4606A>G	c.(4606-4608)ATG>GTG	p.M1536V		NM_004274	NP_004265	Q13023	AKAP6_HUMAN	A-kinase anchor protein 6	1536					protein targeting	calcium channel complex|nuclear membrane|sarcoplasmic reticulum	protein kinase A binding|receptor binding			breast(6)|ovary(5)|lung(4)|skin(3)|large_intestine(2)|pancreas(1)	21	Breast(36;0.0388)|Prostate(35;0.15)		LUAD - Lung adenocarcinoma(48;0.00107)|Lung(238;0.00677)|STAD - Stomach adenocarcinoma(7;0.116)	GBM - Glioblastoma multiforme(265;0.019)		ATCTCATGAAATGGATCGCAT	0.358	Melanoma(49;821 1200 7288 13647 42351)		NA											4	78					0	0	0.009096	0	0
FSCB	84075	broad.mit.edu	37	14	44976080	44976080	+	Missense_Mutation	SNP	G	G	C			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr14:44976080G>C	uc001wvn.2	-	1	420	c.111C>G	c.(109-111)AGC>AGG	p.S37R		NM_032135	NP_115511	Q5H9T9	FSCB_HUMAN	fibrous sheath CABYR binding protein	37						cilium				lung(3)|breast(3)|ovary(2)|central_nervous_system(1)	9				GBM - Glioblastoma multiforme(112;0.128)		AGCTGCCTTTGCTTCCAGAAG	0.413			NA											34	128					0	0	0.012213	0	0
L2HGDH	79944	broad.mit.edu	37	14	50734574	50734574	+	Missense_Mutation	SNP	C	C	A			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr14:50734574C>A	uc001wxu.2	-	8	1040	c.961G>T	c.(961-963)GGC>TGC	p.G321C	L2HGDH_uc010tqn.1_Missense_Mutation_p.G321C|L2HGDH_uc010tqo.1_Missense_Mutation_p.G321C	NM_024884	NP_079160	Q9H9P8	L2HDH_HUMAN	L-2-hydroxyglutarate dehydrogenase precursor	321					2-oxoglutarate metabolic process|cellular protein metabolic process	integral to mitochondrial inner membrane	2-hydroxyglutarate dehydrogenase activity			ovary(2)	2	all_epithelial(31;0.000599)|Breast(41;0.0102)					CAAATACTGCCATCCATCCTT	0.413			NA											24	68					7.16444e-05	8.25271e-05	0.003954	1	0
NIN	51199	broad.mit.edu	37	14	51239122	51239122	+	Missense_Mutation	SNP	C	C	A			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr14:51239122C>A	uc001wym.2	-	9	1069	c.878G>T	c.(877-879)CGG>CTG	p.R293L	NIN_uc001wyi.2_Missense_Mutation_p.R293L|NIN_uc001wyj.2_RNA|NIN_uc001wyk.2_Missense_Mutation_p.R293L|NIN_uc010tqp.1_Missense_Mutation_p.R299L|NIN_uc001wyo.2_Missense_Mutation_p.R293L|NIN_uc001wyp.1_Missense_Mutation_p.R255L	NM_182946	NP_891991	Q8N4C6	NIN_HUMAN	ninein isoform 5	293					centrosome localization	centrosome|microtubule	calcium ion binding|GTP binding|protein binding			skin(3)|ovary(1)|kidney(1)|central_nervous_system(1)	6	all_epithelial(31;0.00244)|Breast(41;0.127)					GGAGAAGACCCGAAAGCCAAT	0.522			NA	T	PDGFRB	MPD								12	47					6.40141e-05	7.40054e-05	0.010729	1	0
NID2	22795	broad.mit.edu	37	14	52481130	52481130	+	Missense_Mutation	SNP	G	G	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr14:52481130G>T	uc001wzo.2	-	16	3529	c.3295C>A	c.(3295-3297)CCA>ACA	p.P1099T	NID2_uc010tqs.1_Missense_Mutation_p.P1051T|NID2_uc010tqt.1_Missense_Mutation_p.P1099T|NID2_uc001wzp.2_Missense_Mutation_p.P1099T	NM_007361	NP_031387	Q14112	NID2_HUMAN	nidogen 2 precursor	1099						basement membrane	calcium ion binding|collagen binding			pancreas(2)|breast(2)|ovary(1)|liver(1)|skin(1)	7	Breast(41;0.0639)|all_epithelial(31;0.123)					GTCACATCTGGCCGGGGCGTG	0.622			NA									OREG0022678	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	17	45					2.23348e-06	2.77877e-06	0.004007	1	0
OTX2	5015	broad.mit.edu	37	14	57268600	57268600	+	Missense_Mutation	SNP	C	C	A			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr14:57268600C>A	uc001xcp.2	-	3	894	c.723G>T	c.(721-723)CAG>CAT	p.Q241H	OTX2_uc010aou.2_Missense_Mutation_p.Q241H|OTX2_uc001xcq.2_Missense_Mutation_p.Q249H	NM_172337	NP_758840	P32243	OTX2_HUMAN	orthodenticle homeobox 2 isoform b	241					axon guidance|forebrain development|midbrain development|positive regulation of embryonic development|positive regulation of gastrulation|primitive streak formation|protein complex assembly|regulation of fibroblast growth factor receptor signaling pathway|regulation of smoothened signaling pathway	growth cone|nucleus|protein complex	eukaryotic initiation factor 4E binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|sequence-specific DNA binding			ovary(1)	1	Medulloblastoma(1;0.00184)|all_neural(1;0.00414)					CTCCATATCCCTGGGTGGAAA	0.512			NA											29	68					1.16021e-09	1.67967e-09	0.007291	1	0
KCNH5	27133	broad.mit.edu	37	14	63417043	63417043	+	Missense_Mutation	SNP	C	C	A			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr14:63417043C>A	uc001xfx.2	-	7	1228	c.1177G>T	c.(1177-1179)GCT>TCT	p.A393S	KCNH5_uc001xfy.2_Missense_Mutation_p.A393S|KCNH5_uc001xfz.1_Missense_Mutation_p.A335S|KCNH5_uc001xga.2_Missense_Mutation_p.A335S	NM_139318	NP_647479	Q8NCM2	KCNH5_HUMAN	potassium voltage-gated channel, subfamily H,	393	Extracellular (Potential).				regulation of transcription, DNA-dependent	integral to membrane	calmodulin binding|two-component sensor activity|voltage-gated potassium channel activity			ovary(4)|skin(4)|central_nervous_system(1)	9				OV - Ovarian serous cystadenocarcinoma(108;0.00958)|BRCA - Breast invasive adenocarcinoma(234;0.168)		ATGCTCAAAGCCAGCTGGTAG	0.498			NA											15	68					1.52009e-12	2.42681e-12	0.003163	1	0
CCDC88C	440193	broad.mit.edu	37	14	91749723	91749723	+	Missense_Mutation	SNP	G	G	A			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr14:91749723G>A	uc010aty.2	-	26	4679	c.4580C>T	c.(4579-4581)ACA>ATA	p.T1527I	CCDC88C_uc001xzj.2_Missense_Mutation_p.T51I|CCDC88C_uc001xzi.2_5'UTR	NM_001080414	NP_001073883	Q9P219	DAPLE_HUMAN	DVL-binding protein DAPLE	1527					microtubule cytoskeleton organization|protein destabilization|protein homooligomerization|regulation of protein phosphorylation|Wnt receptor signaling pathway	cytoplasm|insoluble fraction	microtubule binding|PDZ domain binding|protein self-association			ovary(3)	3		all_cancers(154;0.0468)				GGAAGGGGCTGTAGTGGTGGC	0.647			NA											5	31					0	0	0.000602	0	0
C14orf49	161176	broad.mit.edu	37	14	95899631	95899631	+	Missense_Mutation	SNP	T	T	C			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr14:95899631T>C	uc001yei.3	-	15	2669	c.2654A>G	c.(2653-2655)TAC>TGC	p.Y885C	C14orf49_uc010avi.2_Missense_Mutation_p.Y880C	NM_152592	NP_689805	Q6ZMZ3	SYNE3_HUMAN	nesprin-3	885	Cytoplasmic (Potential).				cytoskeletal anchoring at nuclear membrane	integral to membrane|nuclear outer membrane|SUN-KASH complex	actin binding			central_nervous_system(1)	1		all_cancers(154;0.0937)		COAD - Colon adenocarcinoma(157;0.245)		CTTGGACTTGTACAGCATCCA	0.572			NA											24	105					0	0	0.003954	0	0
DYNC1H1	1778	broad.mit.edu	37	14	102452915	102452915	+	Missense_Mutation	SNP	G	G	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr14:102452915G>T	uc001yks.2	+	8	2517	c.2353G>T	c.(2353-2355)GTT>TTT	p.V785F		NM_001376	NP_001367	Q14204	DYHC1_HUMAN	cytoplasmic dynein 1 heavy chain 1	785	Interaction with DYNC1LI2 (By similarity).|Stem (By similarity).				cytoplasmic mRNA processing body assembly|G2/M transition of mitotic cell cycle|microtubule-based movement|mitotic spindle organization|stress granule assembly|transport	centrosome|cytoplasmic dynein complex|cytosol|Golgi apparatus|microtubule	ATP binding|ATPase activity, coupled|microtubule motor activity|protein binding			ovary(7)|central_nervous_system(2)|pancreas(1)	10						GATCGAGAGCGTTCGTACCTA	0.532			NA											19	107					1.33834e-09	1.93315e-09	0.007413	1	0
AHNAK2	113146	broad.mit.edu	37	14	105413664	105413664	+	Missense_Mutation	SNP	C	C	G			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr14:105413664C>G	uc010axc.1	-	7	8244	c.8124G>C	c.(8122-8124)CAG>CAC	p.Q2708H	AHNAK2_uc001ypx.2_Missense_Mutation_p.Q2608H	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	2708						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			CCTGGCCAGCCTGGACCTCCA	0.612			NA											39	244					0	0	0.005524	0	0
AHNAK2	113146	broad.mit.edu	37	14	105417186	105417186	+	Silent	SNP	C	C	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr14:105417186C>T	uc010axc.1	-	7	4722	c.4602G>A	c.(4600-4602)GGG>GGA	p.G1534G	AHNAK2_uc001ypx.2_Silent_p.G1434G	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	1534						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			CCTTGAGGTCCCCCTGCATGG	0.652			NA											12	267					0	0	0.01441	0	0
AHNAK2	113146	broad.mit.edu	37	14	105417188	105417188	+	Missense_Mutation	SNP	C	C	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr14:105417188C>T	uc010axc.1	-	7	4720	c.4600G>A	c.(4600-4602)GGG>AGG	p.G1534R	AHNAK2_uc001ypx.2_Missense_Mutation_p.G1434R	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	1534						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			TTGAGGTCCCCCTGCATGGAG	0.652			NA											11	273					0	0	0.01441	0	0
OR4M2	390538	broad.mit.edu	37	15	22368804	22368804	+	Missense_Mutation	SNP	A	A	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr15:22368804A>T	uc010tzu.1	+	1	229	c.229A>T	c.(229-231)ACA>TCA	p.T77S	LOC727924_uc001yua.2_Intron|LOC727924_uc001yub.1_Intron|OR4N4_uc001yuc.1_Intron	NM_001004719	NP_001004719	Q8NGB6	OR4M2_HUMAN	olfactory receptor, family 4, subfamily M,	77	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		all_cancers(20;1.94e-20)|all_epithelial(15;3.94e-18)|Lung NSC(15;8.53e-15)|all_lung(15;2.87e-14)|Breast(32;0.00519)|Colorectal(260;0.101)	GBM - Glioblastoma multiforme(6;0.124)	all cancers(64;1.64e-11)|Epithelial(43;5.81e-10)|BRCA - Breast invasive adenocarcinoma(123;0.000255)|Kidney(6;0.00736)|KIRC - Kidney renal clear cell carcinoma(6;0.0135)|GBM - Glioblastoma multiforme(186;0.0963)		CTCTTCCATTACAGCCCCTGA	0.433			NA											47	540					0	0	0.011902	0	0
OR4M2	390538	broad.mit.edu	37	15	22368830	22368830	+	Missense_Mutation	SNP	C	C	G			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr15:22368830C>G	uc010tzu.1	+	1	255	c.255C>G	c.(253-255)TTC>TTG	p.F85L	LOC727924_uc001yua.2_RNA|LOC727924_uc001yub.1_Intron|OR4N4_uc001yuc.1_Intron	NM_001004719	NP_001004719	Q8NGB6	OR4M2_HUMAN	olfactory receptor, family 4, subfamily M,	85	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		all_cancers(20;1.94e-20)|all_epithelial(15;3.94e-18)|Lung NSC(15;8.53e-15)|all_lung(15;2.87e-14)|Breast(32;0.00519)|Colorectal(260;0.101)	GBM - Glioblastoma multiforme(6;0.124)	all cancers(64;1.64e-11)|Epithelial(43;5.81e-10)|BRCA - Breast invasive adenocarcinoma(123;0.000255)|Kidney(6;0.00736)|KIRC - Kidney renal clear cell carcinoma(6;0.0135)|GBM - Glioblastoma multiforme(186;0.0963)		TCATAGACTTCTTTGTGGAGA	0.443			NA											17	522					0	0	0.004007	0	0
Unknown	0	broad.mit.edu	37	15	22440455	22440455	+	Missense_Mutation	SNP	G	G	A			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr15:22440455G>A	uc001yug.2	-	1	411	c.392C>T	c.(391-393)CCT>CTT	p.P131L						full-length cDNA clone CS0DI014YE21 of Placenta Cot 25-normalized of Homo sapiens (human).												NA						TTCTTCCTCAGGAGTCAGCTT	0.463			NA											4	26					0	0	0.009096	0	0
RYR3	6263	broad.mit.edu	37	15	34077909	34077909	+	Silent	SNP	C	C	A			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr15:34077909C>A	uc001zhi.2	+	66	9385	c.9315C>A	c.(9313-9315)CCC>CCA	p.P3105P	RYR3_uc010bar.2_Silent_p.P3105P	NM_001036	NP_001027	Q15413	RYR3_HUMAN	ryanodine receptor 3	3105					cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(5)|central_nervous_system(4)|lung(1)	10		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		CTGACATCCCCCAGCTGGAAG	0.527			NA											4	62					0.00909568	0.00960854	0.009096	1	0
PAK6	56924	broad.mit.edu	37	15	40564615	40564615	+	Missense_Mutation	SNP	G	G	A			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr15:40564615G>A	uc010bbl.2	+	6	1489	c.1049G>A	c.(1048-1050)GGA>GAA	p.G350E	PAK6_uc010bbm.2_Missense_Mutation_p.G350E|PAK6_uc001zky.3_Missense_Mutation_p.G350E|PAK6_uc010bbn.2_Missense_Mutation_p.G350E|PAK6_uc001zlb.2_Missense_Mutation_p.G350E	NM_001128628	NP_001122100	Q9NQU5	PAK6_HUMAN	p21-activated kinase 6	350	Linker.						ATP binding|protein binding|protein serine/threonine kinase activity			lung(5)|large_intestine(1)|ovary(1)|skin(1)	8		all_cancers(109;1.13e-18)|all_epithelial(112;1.62e-15)|Lung NSC(122;5.67e-11)|all_lung(180;1.41e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0823)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;1.51e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0544)		TCCCCAGCGGGATCCCCCCGC	0.677			NA											11	49					0	0	0.008291	0	0
NDUFAF1	51103	broad.mit.edu	37	15	41687110	41687110	+	Missense_Mutation	SNP	T	T	C			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr15:41687110T>C	uc001znx.2	-	3	1088	c.706A>G	c.(706-708)ATG>GTG	p.M236V	NDUFAF1_uc010bcf.2_RNA	NM_016013	NP_057097	Q9Y375	CIA30_HUMAN	NADH dehydrogenase (ubiquinone) 1 alpha	236					mitochondrial electron transport, NADH to ubiquinone|protein complex assembly	mitochondrial respiratory chain complex I	unfolded protein binding			ovary(1)	1		all_cancers(109;5.07e-19)|all_epithelial(112;2.43e-16)|Lung NSC(122;1.81e-11)|all_lung(180;4.81e-10)|Melanoma(134;0.0179)|Colorectal(260;0.0946)|Ovarian(310;0.143)		OV - Ovarian serous cystadenocarcinoma(18;8e-17)|GBM - Glioblastoma multiforme(113;1.38e-06)|BRCA - Breast invasive adenocarcinoma(123;0.114)		TAACTATACATCTGATTCGTC	0.448			NA											12	51					0	0	0.010729	0	0
SORD	6652	broad.mit.edu	37	15	45365705	45365705	+	Missense_Mutation	SNP	G	G	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr15:45365705G>T	uc001zul.3	+	9	1192	c.1051G>T	c.(1051-1053)GAC>TAC	p.D351Y	SORD_uc001zum.3_3'UTR|SORD_uc010bdz.2_Missense_Mutation_p.D272Y	NM_003104	NP_003095	Q00796	DHSO_HUMAN	sorbitol dehydrogenase	351					fructose biosynthetic process|glucose metabolic process|L-xylitol catabolic process|sorbitol catabolic process|sperm motility	cilium|extracellular space|flagellum|membrane fraction|mitochondrial membrane|soluble fraction	L-iditol 2-dehydrogenase activity|NAD binding|sugar binding|zinc ion binding				0		all_cancers(109;3.43e-12)|all_epithelial(112;2.33e-10)|Lung NSC(122;6.01e-07)|all_lung(180;4.38e-06)|Melanoma(134;0.0122)		all cancers(107;1.6e-18)|GBM - Glioblastoma multiforme(94;4.95e-07)|COAD - Colon adenocarcinoma(120;0.0704)|Colorectal(133;0.0706)	NADH(DB00157)	GCTCAAGTGTGACCCCAGTGA	0.507			NA											13	65					9.22233e-05	0.000105469	0.004656	1	0
SEMA6D	80031	broad.mit.edu	37	15	48052056	48052056	+	Missense_Mutation	SNP	G	G	C			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr15:48052056G>C	uc010bek.2	+	2	421	c.61G>C	c.(61-63)GTC>CTC	p.V21L	SEMA6D_uc001zvw.2_Missense_Mutation_p.V21L|SEMA6D_uc001zvx.1_Missense_Mutation_p.V21L|SEMA6D_uc001zvy.2_Missense_Mutation_p.V21L|SEMA6D_uc001zvz.2_Missense_Mutation_p.V21L|SEMA6D_uc001zwa.2_Missense_Mutation_p.V21L|SEMA6D_uc001zwb.2_Missense_Mutation_p.V21L|SEMA6D_uc001zwc.2_Missense_Mutation_p.V21L	NM_153618	NP_705871	Q8NFY4	SEM6D_HUMAN	semaphorin 6D isoform 4 precursor	21	Extracellular (Potential).				axon guidance	cytoplasm|integral to membrane|plasma membrane	receptor activity			skin(3)|breast(1)	4		all_lung(180;0.000635)|Myeloproliferative disorder(241;0.116)|Melanoma(134;0.18)		all cancers(107;1.2e-11)|GBM - Glioblastoma multiforme(94;1.2e-06)		GTTGAGGGCAGTCAGCTTTCC	0.483			NA											17	83					0	0	0.008871	0	0
C15orf33	196951	broad.mit.edu	37	15	49800432	49800432	+	Missense_Mutation	SNP	C	C	G			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr15:49800432C>G	uc001zxl.2	-	11	1282	c.988G>C	c.(988-990)GAC>CAC	p.D330H	C15orf33_uc001zxm.2_Missense_Mutation_p.D296H	NM_152647	NP_689860	Q96M60	CO033_HUMAN	hypothetical protein LOC196951	330										ovary(1)	1		all_lung(180;0.00187)		all cancers(107;3.45e-08)|GBM - Glioblastoma multiforme(94;0.000124)		TCTTGACTGTCTGCAATTCTT	0.338			NA											5	45					0	0	0.000602	0	0
ISLR2	57611	broad.mit.edu	37	15	74425301	74425301	+	Missense_Mutation	SNP	G	G	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr15:74425301G>T	uc002axd.2	+	4	975	c.206G>T	c.(205-207)GGG>GTG	p.G69V	ISLR2_uc002axe.2_Missense_Mutation_p.G69V|ISLR2_uc010bjg.2_Missense_Mutation_p.G69V|ISLR2_uc010bjf.2_Missense_Mutation_p.G69V	NM_001130136	NP_001123608	Q6UXK2	ISLR2_HUMAN	immunoglobulin superfamily containing	69	LRR 1.|Extracellular (Potential).				positive regulation of axon extension	cell surface|integral to membrane|plasma membrane					0						CTGCGGCGCGGGGCCTTCGCC	0.637			NA											18	61					1.67942e-08	2.35118e-08	0.006122	1	0
CIB2	10518	broad.mit.edu	37	15	78401674	78401674	+	Silent	SNP	C	C	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr15:78401674C>T	uc002bdb.1	-	4	570	c.249G>A	c.(247-249)GAG>GAA	p.E83E	CIB2_uc002bdc.1_Silent_p.E40E|CIB2_uc010ums.1_Silent_p.E83E	NM_006383	NP_006374	O75838	CIB2_HUMAN	DNA-dependent protein kinase catalytic	83	EF-hand 1.						calcium ion binding				0						TGAGGTTCCCCTCACCATCCT	0.512			NA											4	69					0	0	0.009096	0	0
ZNF592	9640	broad.mit.edu	37	15	85345586	85345586	+	Missense_Mutation	SNP	C	C	G			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr15:85345586C>G	uc002bld.2	+	11	4102	c.3766C>G	c.(3766-3768)CAG>GAG	p.Q1256E	ZNF592_uc010upb.1_RNA	NM_014630	NP_055445	Q92610	ZN592_HUMAN	zinc finger protein 592	1256					cell death|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(4)|skin(2)	6			BRCA - Breast invasive adenocarcinoma(143;0.0587)			ACAGGCCTCTCAGGACCAGGA	0.622			NA											3	38					0	0	0.004672	0	0
ACAN	176	broad.mit.edu	37	15	89401442	89401442	+	Missense_Mutation	SNP	G	G	A			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr15:89401442G>A	uc010upo.1	+	12	6000	c.5626G>A	c.(5626-5628)GGA>AGA	p.G1876R	ACAN_uc010upp.1_Missense_Mutation_p.G1876R|ACAN_uc002bna.2_RNA	NM_013227	NP_037359	E7EX88	E7EX88_HUMAN	aggrecan isoform 2 precursor	1876					cell adhesion		hyaluronic acid binding|sugar binding			ovary(2)|central_nervous_system(1)	3	Lung NSC(78;0.0392)|all_lung(78;0.077)		BRCA - Breast invasive adenocarcinoma(143;0.146)			GGATGTCAGTGGACAGTTTTC	0.507			NA											10	41					0	0	0.006214	0	0
FAM169B	283777	broad.mit.edu	37	15	98995202	98995202	+	Silent	SNP	C	C	A			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr15:98995202C>A	uc002buk.1	-	5	472	c.222G>T	c.(220-222)CTG>CTT	p.L74L		NM_182562	NP_872368	Q8N8A8	F169B_HUMAN	hypothetical protein LOC283777	74											0						AGACAGGCAGCAGGTAGCATG	0.587			NA											8	37					2.17888e-05	2.55607e-05	0.006214	1	0
TPSD1	23430	broad.mit.edu	37	16	1308196	1308196	+	Silent	SNP	G	G	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr16:1308196G>T	uc002clb.1	+	4	666	c.657G>T	c.(655-657)GCG>GCT	p.A219A	TPSD1_uc010brm.1_Silent_p.A148A	NM_012217	NP_036349	Q9BZJ3	TRYD_HUMAN	tryptase delta 1 precursor	219	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity				0		Hepatocellular(780;0.00369)				TGCTGTGTGCGGGGAGCGAAA	0.622			NA											12	29					5.50884e-06	6.65869e-06	0.013537	1	0
TPSD1	23430	broad.mit.edu	37	16	1308350	1308350	+	Silent	SNP	C	C	A			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr16:1308350C>A	uc002clb.1	+	5	711	c.702C>A	c.(700-702)CCC>CCA	p.P234P		NM_012217	NP_036349	Q9BZJ3	TRYD_HUMAN	tryptase delta 1 precursor	234	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity				0		Hepatocellular(780;0.00369)				CTGGAGGGCCCCTGGTCTGCA	0.667			NA											17	68					3.52763e-06	4.34642e-06	0.00499	1	0
PDILT	204474	broad.mit.edu	37	16	20370659	20370659	+	Silent	SNP	T	T	C			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr16:20370659T>C	uc002dhc.1	-	12	1960	c.1737A>G	c.(1735-1737)AAA>AAG	p.K579K		NM_174924	NP_777584	Q8N807	PDILT_HUMAN	protein disulfide isomerase-like, testis	579					cell differentiation|cell redox homeostasis|multicellular organismal development|spermatogenesis	endoplasmic reticulum	isomerase activity			large_intestine(1)	1						CTTCCTTGACTTTTGGTTTCT	0.443			NA											36	140					0	0	0.003755	0	0
SULT1A1	6817	broad.mit.edu	37	16	28620185	28620185	+	Translation_Start_Site	SNP	G	G	A			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr16:28620185G>A	uc002dqi.2	-	1	465	c.-8C>T	c.(-10--6)GACGC>GATGC		uc010vct.1_Intron|SULT1A1_uc002dqj.2_Intron|SULT1A1_uc002dqk.2_Translation_Start_Site|SULT1A1_uc002dql.2_Intron|SULT1A1_uc002dqm.2_Intron|SULT1A1_uc002dqn.2_Intron|SULT1A1_uc002dqo.2_Intron|SULT1A1_uc002dqp.2_Intron	NM_177534	NP_803878	P50225	ST1A1_HUMAN	sulfotransferase family, cytosolic, 1A,						3'-phosphoadenosine 5'-phosphosulfate metabolic process|catecholamine metabolic process|flavonoid metabolic process|steroid metabolic process|sulfation|xenobiotic metabolic process	cytosol	aryl sulfotransferase activity|flavonol 3-sulfotransferase activity				0						ATGTTCCTGCGTCAGGGGCCA	0.483			NA											6	140					0	0	0.001984	0	0
BCKDK	10295	broad.mit.edu	37	16	31121042	31121042	+	Missense_Mutation	SNP	C	C	A			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr16:31121042C>A	uc002eaw.3	+	4	629	c.313C>A	c.(313-315)CGC>AGC	p.R105S	BCKDK_uc002eav.3_Missense_Mutation_p.R105S|BCKDK_uc010cah.2_RNA|BCKDK_uc010cai.2_Missense_Mutation_p.R105S	NM_005881	NP_005872	O14874	BCKD_HUMAN	branched chain ketoacid dehydrogenase kinase	105					branched chain family amino acid catabolic process|peptidyl-histidine phosphorylation	mitochondrial alpha-ketoglutarate dehydrogenase complex	[3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] kinase activity|ATP binding|protein binding|protein serine/threonine kinase activity|two-component sensor activity			stomach(1)|breast(1)	2						GATTGCTCACCGCATCAAGGG	0.567			NA											8	70					2.17888e-05	2.55607e-05	0.006214	1	0
ABCC11	85320	broad.mit.edu	37	16	48212511	48212511	+	Missense_Mutation	SNP	C	C	A			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr16:48212511C>A	uc002eff.1	-	23	3695	c.3345G>T	c.(3343-3345)ATG>ATT	p.M1115I	ABCC11_uc002efg.1_Missense_Mutation_p.M1115I|ABCC11_uc002efh.1_Missense_Mutation_p.M1115I|ABCC11_uc010cbg.1_RNA	NM_033151	NP_149163	Q96J66	ABCCB_HUMAN	ATP-binding cassette, sub-family C, member 11	1115	Cytoplasmic (Potential).					integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(3)|skin(2)|central_nervous_system(1)	6		all_cancers(37;0.127)|all_lung(18;0.132)|Breast(268;0.166)				ACCCCACCTTCATGTACTGCA	0.587			NA							Cerumen_Type				17	88					6.94344e-10	1.01212e-09	0.006122	1	0
SALL1	6299	broad.mit.edu	37	16	51175648	51175648	+	Missense_Mutation	SNP	C	C	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr16:51175648C>T	uc010vgs.1	-	2	516	c.485G>A	c.(484-486)GGC>GAC	p.G162D	SALL1_uc010vgr.1_Missense_Mutation_p.G65D|SALL1_uc010cbv.2_Intron	NM_002968	NP_002959	Q9NSC2	SALL1_HUMAN	sal-like 1 isoform a	162	Poly-Gly.				adrenal gland development|branching involved in ureteric bud morphogenesis|embryonic digestive tract development|embryonic digit morphogenesis|gonad development|histone deacetylation|inductive cell-cell signaling|mesenchymal to epithelial transition involved in metanephros morphogenesis|negative regulation of transcription from RNA polymerase II promoter|olfactory bulb interneuron differentiation|olfactory bulb mitral cell layer development|olfactory nerve development|outer ear morphogenesis|pituitary gland development|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway|ureteric bud invasion|ventricular septum development	chromocenter|cytoplasm|heterochromatin|nucleus	beta-catenin binding|DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(5)|ovary(3)	8		all_cancers(37;0.0322)	COAD - Colon adenocarcinoma(2;0.24)			GGAgctgccgccgccgccgct	0.458	GBM(103;1352 1446 1855 4775 8890)		NA											21	44					0	0	0.008871	0	0
RLTPR	146206	broad.mit.edu	37	16	67679982	67679982	+	Missense_Mutation	SNP	A	A	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr16:67679982A>T	uc002etn.2	+	4	368	c.248A>T	c.(247-249)CAG>CTG	p.Q83L	RLTPR_uc010cel.1_Missense_Mutation_p.Q83L|RLTPR_uc010vjr.1_Missense_Mutation_p.Q83L	NM_001013838	NP_001013860	Q6F5E8	LR16C_HUMAN	RGD motif, leucine rich repeats, tropomodulin	83	LRR 1.									breast(1)	1		Acute lymphoblastic leukemia(13;3.23e-05)|all_hematologic(13;0.00251)|Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0146)|Epithelial(162;0.0481)|all cancers(182;0.232)		ACACCCCCTCAGGTGAGACAC	0.622			NA											23	104					0	0	0.014323	0	0
SF3B3	23450	broad.mit.edu	37	16	70590926	70590926	+	Silent	SNP	G	G	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr16:70590926G>T	uc002ezf.2	+	15	2215	c.2004G>T	c.(2002-2004)GGG>GGT	p.G668G		NM_012426	NP_036558	Q15393	SF3B3_HUMAN	splicing factor 3b, subunit 3	668					protein complex assembly	catalytic step 2 spliceosome|nucleoplasm|small nuclear ribonucleoprotein complex|U12-type spliceosomal complex	nucleic acid binding|protein binding			ovary(1)	1		Ovarian(137;0.0694)				TGAATATTGGGCTACAGGTAA	0.507			NA											10	37					1.76689e-08	2.45209e-08	0.006214	1	0
TAT	6898	broad.mit.edu	37	16	71604215	71604215	+	Missense_Mutation	SNP	C	C	A			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr16:71604215C>A	uc002fap.2	-	9	1097	c.998G>T	c.(997-999)CGC>CTC	p.R333L		NM_000353	NP_000344	P17735	ATTY_HUMAN	tyrosine aminotransferase	333					2-oxoglutarate metabolic process|glutamate metabolic process|L-phenylalanine catabolic process|tyrosine catabolic process	cytosol	1-aminocyclopropane-1-carboxylate synthase activity|L-tyrosine:2-oxoglutarate aminotransferase activity|pyridoxal phosphate binding			ovary(2)	2		Ovarian(137;0.125)		Kidney(780;0.0157)	L-Glutamic Acid(DB00142)|L-Phenylalanine(DB00120)|L-Tyrosine(DB00135)|Pyridoxal Phosphate(DB00114)	TCCCGGGGTGCGACATAGGAT	0.552	Melanoma(198;542 2142 10292 21661 50033)|Esophageal Squamous(48;487 1013 5572 44395 52594)		NA											11	57					1.58986e-06	2.01341e-06	0.008291	1	0
TP53	7157	broad.mit.edu	37	17	7578290	7578290	+	Splice_Site	SNP	C	C	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr17:7578290C>T	uc002gim.2	-	6	754	c.560_splice	c.e6-1	p.G187_splice	TP53_uc002gig.1_Splice_Site_p.G187_splice|TP53_uc002gih.2_Splice_Site_p.G187_splice|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Splice_Site_p.G55_splice|TP53_uc010cng.1_Splice_Site_p.G55_splice|TP53_uc002gii.1_Splice_Site_p.G55_splice|TP53_uc010cnh.1_Splice_Site_p.G187_splice|TP53_uc010cni.1_Splice_Site_p.G187_splice|TP53_uc002gij.2_Splice_Site_p.G187_splice|TP53_uc010cnj.1_Intron|TP53_uc002gin.2_Splice_Site_p.G94_splice|TP53_uc002gio.2_Splice_Site_p.G55_splice|TP53_uc010vug.1_Intron	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a						activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.?(24)|p.0?(7)|p.G187fs*16(2)|p.D186_P191delDGLAPP(1)|p.L188fs*19(1)|p.G187_L188delGL(1)|p.G187fs*22(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GGGGCCAGACCTAAGAGCAAT	0.552	Pancreas(47;798 1329 9957 10801)		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumensyndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			10	40					0	0	0.006214	0	0
MYH13	8735	broad.mit.edu	37	17	10247257	10247257	+	Missense_Mutation	SNP	G	G	C			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr17:10247257G>C	uc002gmk.1	-	16	1844	c.1754C>G	c.(1753-1755)GCC>GGC	p.A585G	MYH13_uc010vvf.1_Missense_Mutation_p.A260G	NM_003802	NP_003793	Q9UKX3	MYH13_HUMAN	myosin, heavy polypeptide 13, skeletal muscle	585	Myosin head-like.				muscle contraction	muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(4)|skin(2)	6						CACGGTGCCGGCATAGTGCAC	0.547			NA											22	78					0	0	0.00333	0	0
MYH8	4626	broad.mit.edu	37	17	10295913	10295913	+	Missense_Mutation	SNP	C	C	A			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr17:10295913C>A	uc002gmm.2	-	38	5609	c.5514G>T	c.(5512-5514)GAG>GAT	p.E1838D	uc002gml.1_Intron	NM_002472	NP_002463	P13535	MYH8_HUMAN	myosin, heavy chain 8, skeletal muscle,	1838	Potential.				muscle filament sliding	cytosol|muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			skin(6)|ovary(3)|breast(2)	11						CTTTAACAGCCTCTGCATTAC	0.438			NA							Trismus-Pseudocamptodactyly_Syndrome_with_Cardiac_Myxoma_and_Freckling				17	106					8.10497e-08	1.09615e-07	0.010504	1	0
CYTSB	92521	broad.mit.edu	37	17	20108350	20108350	+	Missense_Mutation	SNP	G	G	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr17:20108350G>T	uc002gwq.2	+	4	1133	c.988G>T	c.(988-990)GAC>TAC	p.D330Y	CYTSB_uc010cqx.2_Missense_Mutation_p.D330Y|CYTSB_uc002gwr.2_Missense_Mutation_p.D330Y|CYTSB_uc002gws.2_Missense_Mutation_p.D330Y|CYTSB_uc002gwv.2_Missense_Mutation_p.D249Y|CYTSB_uc010vzf.1_Intron|CYTSB_uc002gww.2_Missense_Mutation_p.D106Y|CYTSB_uc002gwt.2_Missense_Mutation_p.D249Y|CYTSB_uc002gwu.2_Missense_Mutation_p.D249Y	NM_001033553	NP_001028725	Q5M775	CYTSB_HUMAN	spectrin domain with coiled-coils 1 NSP5b3b	330	Ser-rich.			D -> N (in Ref. 5; AAH50058).		nucleus					0						AGATGCTTCCGACTTTGAGCA	0.458			NA											18	185					2.39187e-15	4.09576e-15	0.008871	1	0
C17orf75	64149	broad.mit.edu	37	17	30665284	30665284	+	Missense_Mutation	SNP	C	C	A			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr17:30665284C>A	uc002hhg.2	-	4	465	c.434G>T	c.(433-435)CGT>CTT	p.R145L		NM_022344	NP_071739	Q9HAS0	NJMU_HUMAN	hypothetical protein LOC64149	145					spermatogenesis					ovary(1)	1		Breast(31;0.116)|Ovarian(249;0.182)	BRCA - Breast invasive adenocarcinoma(9;0.239)			TGAAGGGTTACGTTCAGAGTC	0.373			NA											27	137					8.24728e-16	1.43148e-15	0.004656	1	0
KRT12	3859	broad.mit.edu	37	17	39023359	39023359	+	Missense_Mutation	SNP	A	A	G			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr17:39023359A>G	uc002hvk.2	-	1	104	c.80T>C	c.(79-81)ATA>ACA	p.I27T		NM_000223	NP_000214	Q99456	K1C12_HUMAN	keratin 12	27	Head.				visual perception	intermediate filament	structural molecule activity			ovary(1)	1		Breast(137;0.000301)				GGGTCTGCCTATCACACTCTG	0.602			NA											8	73					0	0	0.008291	0	0
DNAJC7	7266	broad.mit.edu	37	17	40134324	40134324	+	Nonsense_Mutation	SNP	C	C	A			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr17:40134324C>A	uc002hyo.2	-	11	1417	c.1180G>T	c.(1180-1182)GAG>TAG	p.E394*	DNAJC7_uc010cxu.2_Nonsense_Mutation_p.E338*|DNAJC7_uc010cxv.2_Intron|DNAJC7_uc010wgb.1_Nonsense_Mutation_p.E338*|DNAJC7_uc010wgc.1_Nonsense_Mutation_p.E252*|DNAJC7_uc002hyp.2_Nonsense_Mutation_p.E338*	NM_003315	NP_003306	Q99615	DNJC7_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 7	394	J.				chaperone cofactor-dependent protein refolding	cytoplasm|cytoskeleton|nucleus	heat shock protein binding|unfolded protein binding			ovary(1)	1		all_cancers(22;0.00273)|Breast(137;0.00104)|all_epithelial(22;0.0305)				ATCTCGTCCTCAGAGGCATTC	0.498	Colon(63;618 1117 8600 10857 19751)		NA											10	73					0.000442599	0.000496366	0.006214	1	0
NPEPPS	9520	broad.mit.edu	37	17	45668224	45668224	+	Missense_Mutation	SNP	T	T	G			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr17:45668224T>G	uc002ilr.3	+	10	1460	c.1237T>G	c.(1237-1239)TTA>GTA	p.L413V	NPEPPS_uc010wkt.1_Missense_Mutation_p.L409V|NPEPPS_uc010wku.1_Missense_Mutation_p.L377V|NPEPPS_uc010wkv.1_5'UTR	NM_006310	NP_006301	P55786	PSA_HUMAN	aminopeptidase puromycin sensitive	413					proteolysis	cytosol|nucleus	aminopeptidase activity|metallopeptidase activity|protein binding|zinc ion binding				0						GCTTGACGCCTTAGATAACAG	0.408			NA											12	161					0	0	0.004007	0	0
CACNA1G	8913	broad.mit.edu	37	17	48692748	48692748	+	Missense_Mutation	SNP	G	G	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr17:48692748G>T	uc002irk.1	+	27	5158	c.4786G>T	c.(4786-4788)GAC>TAC	p.D1596Y	CACNA1G_uc002irj.1_Missense_Mutation_p.D1562Y|CACNA1G_uc002irl.1_Missense_Mutation_p.D1573Y|CACNA1G_uc002irm.1_Missense_Mutation_p.D1562Y|CACNA1G_uc002irn.1_Missense_Mutation_p.D1555Y|CACNA1G_uc002iro.1_Missense_Mutation_p.D1562Y|CACNA1G_uc002irp.1_Missense_Mutation_p.D1596Y|CACNA1G_uc002irq.1_Missense_Mutation_p.D1573Y|CACNA1G_uc002irr.1_Missense_Mutation_p.D1596Y|CACNA1G_uc002irs.1_Missense_Mutation_p.D1585Y|CACNA1G_uc002irt.1_Missense_Mutation_p.D1578Y|CACNA1G_uc002irv.1_Missense_Mutation_p.D1585Y|CACNA1G_uc002irw.1_Missense_Mutation_p.D1573Y|CACNA1G_uc002iru.1_Missense_Mutation_p.D1562Y|CACNA1G_uc002irx.1_Missense_Mutation_p.D1509Y|CACNA1G_uc002iry.1_Missense_Mutation_p.D1498Y|CACNA1G_uc002irz.1_Missense_Mutation_p.D1509Y|CACNA1G_uc002isa.1_Missense_Mutation_p.D1475Y|CACNA1G_uc002isb.1_Missense_Mutation_p.D1516Y|CACNA1G_uc002isc.1_Missense_Mutation_p.D1498Y|CACNA1G_uc002isd.1_Missense_Mutation_p.D1491Y|CACNA1G_uc002ise.1_Missense_Mutation_p.D1464Y|CACNA1G_uc002isf.1_Missense_Mutation_p.D1491Y|CACNA1G_uc002isg.1_Missense_Mutation_p.D1457Y|CACNA1G_uc002ish.1_Missense_Mutation_p.D1464Y|CACNA1G_uc002isi.1_Missense_Mutation_p.D1452Y	NM_018896	NP_061496	O43497	CAC1G_HUMAN	voltage-dependent calcium channel alpha 1G	1596	IV.|Cytoplasmic (Potential).				axon guidance	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(1)	1	Breast(11;6.7e-17)		BRCA - Breast invasive adenocarcinoma(22;7.52e-09)		Ethosuximide(DB00593)|Flunarizine(DB04841)|Levetiracetam(DB01202)|Mibefradil(DB01388)|Pimozide(DB01100)|Trimethadione(DB00347)|Verapamil(DB00661)|Zonisamide(DB00909)	TTACTACTCCGACTACTCCCG	0.632			NA											9	51					0.000274275	0.000309227	0.004482	1	0
MPO	4353	broad.mit.edu	37	17	56349109	56349109	+	Missense_Mutation	SNP	C	C	A			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr17:56349109C>A	uc002ivu.1	-	11	2114	c.1937G>T	c.(1936-1938)GGC>GTC	p.G646V		NM_000250	NP_000241	P05164	PERM_HUMAN	myeloperoxidase	646					anti-apoptosis|hydrogen peroxide catabolic process|low-density lipoprotein particle remodeling	extracellular space|lysosome|nucleus|stored secretory granule	chromatin binding|heme binding|heparin binding|peroxidase activity			ovary(2)|large_intestine(1)|pancreas(1)	4					Cefdinir(DB00535)	CTCGGACACGCCGCCCATCCA	0.612			NA											15	53					1.99824e-07	2.65183e-07	0.00499	1	0
TEX14	56155	broad.mit.edu	37	17	56694958	56694958	+	Nonsense_Mutation	SNP	G	G	A			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr17:56694958G>A	uc010dcz.1	-	6	695	c.577C>T	c.(577-579)CGA>TGA	p.R193*	TEX14_uc002iwr.1_Nonsense_Mutation_p.R193*|TEX14_uc002iws.1_Nonsense_Mutation_p.R193*|TEX14_uc010dda.1_Intron	NM_198393	NP_938207	Q8IWB6	TEX14_HUMAN	testis expressed sequence 14 isoform a	193						cytoplasm	ATP binding|protein kinase activity			stomach(4)|lung(3)|breast(3)|ovary(3)|upper_aerodigestive_tract(1)|large_intestine(1)|skin(1)|pancreas(1)	17	Medulloblastoma(34;0.127)|all_neural(34;0.237)					TTAAGCAGTCGGTTAGGAGAG	0.393			NA											5	77					0	0	0.001984	0	0
ABCA8	10351	broad.mit.edu	37	17	66924151	66924151	+	Missense_Mutation	SNP	G	G	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr17:66924151G>T	uc002jhp.2	-	9	1358	c.1179C>A	c.(1177-1179)GAC>GAA	p.D393E	ABCA8_uc002jhq.2_Missense_Mutation_p.D393E|ABCA8_uc010wqq.1_Missense_Mutation_p.D393E|ABCA8_uc010wqr.1_Missense_Mutation_p.D332E|ABCA8_uc002jhr.2_Missense_Mutation_p.D393E	NM_007168	NP_009099	O94911	ABCA8_HUMAN	ATP-binding cassette, sub-family A member 8	393						integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(2)|skin(1)	3	Breast(10;4.56e-13)					GATTTGAGCCGTCCGATGGAT	0.338			NA											8	32					5.18039e-06	6.34598e-06	0.00308	1	0
KIF19	124602	broad.mit.edu	37	17	72345400	72345400	+	Silent	SNP	C	C	A			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr17:72345400C>A	uc002jkm.3	+	10	1263	c.1125C>A	c.(1123-1125)ATC>ATA	p.I375I	KIF19_uc002jkj.2_Silent_p.I375I|KIF19_uc002jkk.2_Silent_p.I333I|KIF19_uc002jkl.2_Silent_p.I333I	NM_153209	NP_694941	Q2TAC6	KIF19_HUMAN	kinesin family member 19	375	Potential.				microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity				0						GGGGCGAGATCCAGCGACTCA	0.637			NA											10	51					1.58986e-06	2.01341e-06	0.008291	1	0
GAA	2548	broad.mit.edu	37	17	78082517	78082517	+	Missense_Mutation	SNP	G	G	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr17:78082517G>T	uc002jxo.2	+	9	1398	c.1216G>T	c.(1216-1218)GAC>TAC	p.D406Y	GAA_uc002jxp.2_Missense_Mutation_p.D406Y|GAA_uc002jxq.2_Missense_Mutation_p.D406Y	NM_001079803	NP_001073271	P10253	LYAG_HUMAN	acid alpha-glucosidase preproprotein	406					cardiac muscle contraction|diaphragm contraction|glycogen catabolic process|lysosome organization|tongue morphogenesis|vacuolar sequestering|ventricular cardiac muscle tissue morphogenesis	lysosomal membrane	carbohydrate binding|maltose alpha-glucosidase activity			ovary(1)	1	all_neural(118;0.117)		OV - Ovarian serous cystadenocarcinoma(97;0.0292)|BRCA - Breast invasive adenocarcinoma(99;0.139)		Acarbose(DB00284)	GAACGACCTGGACTACATGGA	0.667			NA											9	27					3.09899e-07	4.07021e-07	0.004482	1	0
SMCHD1	23347	broad.mit.edu	37	18	2762143	2762143	+	Missense_Mutation	SNP	T	T	C			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr18:2762143T>C	uc002klm.3	+	36	4664	c.4475T>C	c.(4474-4476)GTA>GCA	p.V1492A	SMCHD1_uc002klk.3_RNA|SMCHD1_uc002kll.3_RNA	NM_015295	NP_056110	A6NHR9	SMHD1_HUMAN	structural maintenance of chromosomes flexible	1492					chromosome organization		ATP binding				0						GTGAAGTTAGTACCTAAAATT	0.368			NA											17	61					0	0	0.008871	0	0
LRRC30	339291	broad.mit.edu	37	18	7231664	7231664	+	Silent	SNP	G	G	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr18:7231664G>T	uc010wzk.1	+	1	528	c.528G>T	c.(526-528)GCG>GCT	p.A176A		NM_001105581	NP_001099051	A6NM36	LRC30_HUMAN	leucine rich repeat containing 30	176	LRR 5.									ovary(1)|liver(1)	2						ACTTCTTCGCGCACATCCCCA	0.552			NA											24	118					4.26978e-12	6.71567e-12	0.00333	1	0
PTPRM	5797	broad.mit.edu	37	18	7888243	7888243	+	Silent	SNP	G	G	A			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr18:7888243G>A	uc002knn.3	+	3	839	c.336G>A	c.(334-336)GGG>GGA	p.G112G	PTPRM_uc010dkv.2_Silent_p.G112G	NM_002845	NP_002836	P28827	PTPRM_HUMAN	protein tyrosine phosphatase, receptor type, M	112	MAM.|Extracellular (Potential).				homophilic cell adhesion|negative regulation of angiogenesis|negative regulation of endothelial cell migration|negative regulation of endothelial cell proliferation|response to drug|retina layer formation|retinal ganglion cell axon guidance	cell-cell adherens junction|integral to plasma membrane|lamellipodium|perinuclear region of cytoplasm	cadherin binding|transmembrane receptor protein tyrosine phosphatase activity			lung(3)|ovary(2)|central_nervous_system(1)	6		Colorectal(10;0.234)				CTCCTCCGGGGTTACTCAATG	0.483			NA											21	83					0	0	0.008871	0	0
FAM38B	63895	broad.mit.edu	37	18	10696216	10696216	+	Missense_Mutation	SNP	A	A	C			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr18:10696216A>C	uc002kor.3	-	5	718	c.578T>G	c.(577-579)ATG>AGG	p.M193R	FAM38B_uc002koq.2_Missense_Mutation_p.M91R	NM_022068	NP_071351	Q9H5I5	PIEZ2_HUMAN	family with sequence similarity 38, member B	2236	Helical; (Potential).					integral to membrane	ion channel activity			ovary(1)	1						AATGAGGACCATCACCAAAAA	0.522			NA											11	57					0	0	0.010729	0	0
RNMT	8731	broad.mit.edu	37	18	13731900	13731900	+	Missense_Mutation	SNP	A	A	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr18:13731900A>T	uc002ksk.1	+	2	451	c.384A>T	c.(382-384)AAA>AAT	p.K128N	RNMT_uc002ksl.1_Missense_Mutation_p.K128N|RNMT_uc002ksm.1_Missense_Mutation_p.K128N|RNMT_uc010dlk.2_Missense_Mutation_p.K128N|RNMT_uc010xae.1_Intron	NM_003799	NP_003790	O43148	MCES_HUMAN	RNA (guanine-7-) methyltransferase	128	Nuclear localization signal.				mRNA capping|transcription from RNA polymerase II promoter|viral reproduction	nucleoplasm	mRNA (guanine-N7-)-methyltransferase activity|RNA binding				0						ATAAGAGAAAAATAGCACTTG	0.348	GBM(29;474 594 19092 36647 41529)		NA											13	77					0	0	0.001855	0	0
CABLES1	91768	broad.mit.edu	37	18	20832975	20832975	+	Missense_Mutation	SNP	G	G	A			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr18:20832975G>A	uc002kuc.2	+	8	1498	c.1498G>A	c.(1498-1500)GAG>AAG	p.E500K	C18orf45_uc010xaq.1_Intron|CABLES1_uc002kub.2_Missense_Mutation_p.E3K|CABLES1_uc002kud.2_Missense_Mutation_p.E235K	NM_001100619	NP_001094089	Q8TDN4	CABL1_HUMAN	Cdk5 and Abl enzyme substrate 1 isoform 2	500					blood coagulation|cell cycle|cell division|regulation of cell cycle|regulation of cell division	cytosol|nucleus	cyclin-dependent protein kinase regulator activity|protein binding			breast(1)	1	all_cancers(21;0.000102)|all_epithelial(16;2.48e-06)|Lung NSC(20;0.00696)|all_lung(20;0.0197)|Colorectal(14;0.0202)|Ovarian(20;0.127)					GGACATGAACGAGACCTTCAA	0.488			NA											9	57					0	0	0.010729	0	0
C18orf8	29919	broad.mit.edu	37	18	21110037	21110037	+	Missense_Mutation	SNP	C	C	G			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr18:21110037C>G	uc010xax.1	+	18	1661	c.1540C>G	c.(1540-1542)CTC>GTC	p.L514V	C18orf8_uc002kul.2_RNA|C18orf8_uc010xay.1_Missense_Mutation_p.L138V|NPC1_uc010dlu.1_Intron	NM_013326	NP_037458	Q96DM3	MIC1_HUMAN	colon cancer-associated protein Mic1	514	Mic1.									ovary(1)	1	all_cancers(21;0.000122)|all_epithelial(16;8.08e-07)|Lung NSC(20;0.00206)|all_lung(20;0.00659)|Colorectal(14;0.0202)|Ovarian(20;0.127)					CCAGCACAACCTCTTTTATAT	0.398			NA											67	340					0	0	0.01441	0	0
DSG3	1830	broad.mit.edu	37	18	29056010	29056010	+	Silent	SNP	T	T	C			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr18:29056010T>C	uc002kws.2	+	16	2896	c.2787T>C	c.(2785-2787)GGT>GGC	p.G929G	DSG3_uc002kwt.2_Silent_p.G211G	NM_001944	NP_001935	P32926	DSG3_HUMAN	desmoglein 3 preproprotein	929	Desmoglein repeat 1.|Cytoplasmic (Potential).				cellular component disassembly involved in apoptosis|homophilic cell adhesion	cytosol|desmosome|integral to membrane	calcium ion binding			skin(4)|ovary(3)|lung(1)|central_nervous_system(1)	9			OV - Ovarian serous cystadenocarcinoma(10;0.00504)			TGCAGCATGGTAACTATTTAG	0.498			NA											21	97					0	0	0.008871	0	0
FAM59A	64762	broad.mit.edu	37	18	29867127	29867127	+	Missense_Mutation	SNP	C	C	A			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr18:29867127C>A	uc002kxl.2	-	4	1489	c.1433G>T	c.(1432-1434)TGT>TTT	p.C478F	FAM59A_uc002kxk.1_Missense_Mutation_p.C478F	NM_022751	NP_073588	Q9H706	FA59A_HUMAN	family with sequence similarity 59, member A	478										ovary(1)|skin(1)	2						AAACTGATCACATCTGTTCTT	0.537			NA											27	106					1.2476e-16	2.18931e-16	0.00632	1	0
ASXL3	80816	broad.mit.edu	37	18	31319709	31319709	+	Missense_Mutation	SNP	C	C	G			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr18:31319709C>G	uc010dmg.1	+	11	2396	c.2341C>G	c.(2341-2343)CCG>GCG	p.P781A	ASXL3_uc002kxq.2_Missense_Mutation_p.P488A	NM_030632	NP_085135	Q9C0F0	ASXL3_HUMAN	additional sex combs like 3	781	Ser-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding			ovary(2)|pancreas(1)	3						GCCACTCTCCCCGCAGAAAGA	0.463			NA											17	71					0	0	0.004007	0	0
NOL4	8715	broad.mit.edu	37	18	31538265	31538265	+	Missense_Mutation	SNP	C	C	G			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr18:31538265C>G	uc010dmi.2	-	7	1403	c.1174G>C	c.(1174-1176)GAC>CAC	p.D392H	NOL4_uc010xbs.1_Missense_Mutation_p.D107H|NOL4_uc002kxr.3_Missense_Mutation_p.D228H|NOL4_uc010xbt.1_Missense_Mutation_p.D318H|NOL4_uc010dmh.2_Missense_Mutation_p.D318H|NOL4_uc010xbu.1_Missense_Mutation_p.D392H|NOL4_uc002kxt.3_Missense_Mutation_p.D392H|NOL4_uc010xbv.1_Missense_Mutation_p.D141H|NOL4_uc010xbw.1_Missense_Mutation_p.D278H	NM_003787	NP_003778	O94818	NOL4_HUMAN	nucleolar protein 4	392						nucleolus	RNA binding			ovary(3)	3						TCCGAATCGTCATGGTCCTCG	0.488			NA											31	172					0	0	0.012213	0	0
DCC	1630	broad.mit.edu	37	18	50450202	50450202	+	Silent	SNP	C	C	A			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr18:50450202C>A	uc002lfe.1	+	4	1410	c.823C>A	c.(823-825)CGA>AGA	p.R275R	DCC_uc010xdr.1_Silent_p.R123R	NM_005215	NP_005206	P43146	DCC_HUMAN	netrin receptor DCC precursor	275	Extracellular (Potential).|Ig-like C2-type 3.				apoptosis|induction of apoptosis|negative regulation of collateral sprouting|negative regulation of dendrite development	cytosol|integral to membrane				skin(8)|ovary(6)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	17		all_cancers(7;0.11)|all_epithelial(6;0.00126)		Colorectal(16;0.0251)|COAD - Colon adenocarcinoma(17;0.0942)		TACCTGGTTACGAGGCGAGGA	0.373			NA											9	42					4.68919e-08	6.39617e-08	0.008291	1	0
ST8SIA3	51046	broad.mit.edu	37	18	55024500	55024500	+	Missense_Mutation	SNP	A	A	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr18:55024500A>T	uc002lgn.2	+	3	1016	c.659A>T	c.(658-660)AAC>ATC	p.N220I		NM_015879	NP_056963	O43173	SIA8C_HUMAN	ST8 alpha-N-acetyl-neuraminide	220	Lumenal (Potential).				glycosphingolipid biosynthetic process|N-glycan processing|post-translational protein modification|protein N-linked glycosylation via asparagine	integral to Golgi membrane	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity			breast(1)|skin(1)	2				READ - Rectum adenocarcinoma(59;0.19)|Colorectal(16;0.205)		AAATATTACAACAATCTCTTG	0.423			NA											12	55					0	0	0.010729	0	0
CDH19	28513	broad.mit.edu	37	18	64172450	64172450	+	Missense_Mutation	SNP	G	G	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr18:64172450G>T	uc002lkc.1	-	12	2056	c.1918C>A	c.(1918-1920)CAA>AAA	p.Q640K	CDH19_uc010dql.1_RNA|CDH19_uc010xey.1_3'UTR	NM_021153	NP_066976	Q9H159	CAD19_HUMAN	cadherin 19, type 2 preproprotein	640	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(1)|skin(1)	2		Esophageal squamous(42;0.0132)				TCATCATATTGGAATATATTC	0.388			NA											22	187					1.55795e-14	2.61161e-14	0.012319	1	0
RTTN	25914	broad.mit.edu	37	18	67812964	67812965	+	Missense_Mutation	DNP	CC	CC	AA			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr18:67812964_67812965CC>AA	uc002lkp.2	-	18	2432_2433	c.2364_2365GG>TT	c.(2362-2367)GGGGCT>GGTTCT	p.A789S	RTTN_uc002lko.2_RNA|RTTN_uc010xfb.1_5'UTR	NM_173630	NP_775901	Q86VV8	RTTN_HUMAN	rotatin	789							binding			ovary(3)|pancreas(2)|skin(1)|breast(1)|central_nervous_system(1)	8		Esophageal squamous(42;0.129)				TTTGTATCAGCCCCTTCTTCAC	0.421			NA											9	92					0	0	0.004672	0	0
ZADH2	284273	broad.mit.edu	37	18	72913562	72913562	+	Missense_Mutation	SNP	C	C	A			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr18:72913562C>A	uc002llx.2	-	2	1211	c.943G>T	c.(943-945)GCC>TCC	p.A315S	ZADH2_uc010dqv.2_Missense_Mutation_p.A192S	NM_175907	NP_787103	Q8N4Q0	ZADH2_HUMAN	zinc binding alcohol dehydrogenase domain	315						peroxisome	oxidoreductase activity|zinc ion binding				0		Esophageal squamous(42;0.131)|Prostate(75;0.155)		READ - Rectum adenocarcinoma(2;0.0276)|BRCA - Breast invasive adenocarcinoma(31;0.216)		TGGCTCATGGCTGCTTGATAC	0.522			NA											10	67					1.76689e-08	2.45209e-08	0.006214	1	0
AZU1	566	broad.mit.edu	37	19	831859	831859	+	Silent	SNP	G	G	A			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr19:831859G>A	uc002lpz.1	+	5	754	c.738G>A	c.(736-738)CCG>CCA	p.P246P		NM_001700	NP_001691	P20160	CAP7_HUMAN	azurocidin 1 preproprotein	246					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|anti-apoptosis|cellular extravasation|defense response to Gram-negative bacterium|glial cell migration|induction of positive chemotaxis|inflammatory response|macrophage chemotaxis|microglial cell activation|monocyte activation|positive regulation of cell adhesion|positive regulation of fractalkine biosynthetic process|positive regulation of interleukin-1 beta biosynthetic process|positive regulation of MHC class II biosynthetic process|positive regulation of phagocytosis|positive regulation of tumor necrosis factor biosynthetic process|proteolysis|regulation of vascular permeability	azurophil granule|extracellular region	heparin binding|serine-type endopeptidase activity|toxin binding			pancreas(1)	1		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;6.59e-06)|all_lung(49;9.97e-06)|Breast(49;0.000172)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TCAACAACCCGGGACCGGGGC	0.473			NA											12	77					0	0	0.003163	0	0
GTF2F1	2962	broad.mit.edu	37	19	6380303	6380303	+	Missense_Mutation	SNP	G	G	C			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr19:6380303G>C	uc002meq.2	-	13	1828	c.1543C>G	c.(1543-1545)CTC>GTC	p.L515V	GTF2F1_uc010xjb.1_Missense_Mutation_p.L336V|GTF2F1_uc010xjc.1_Missense_Mutation_p.L430V	NM_002096	NP_002087	P35269	T2FA_HUMAN	general transcription factor IIF, polypeptide 1,	515					mRNA capping|nuclear mRNA splicing, via spliceosome|positive regulation of transcription, DNA-dependent|positive regulation of viral transcription|response to virus|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	cell junction|transcription factor TFIIF complex	catalytic activity|DNA binding|phosphatase activator activity|transcription coactivator activity|transcription factor binding				0						CACTCCTTGAGGGAGAAGTGC	0.552			NA											30	176					0	0	0.00632	0	0
EMR1	2015	broad.mit.edu	37	19	6897259	6897259	+	Missense_Mutation	SNP	C	C	A			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr19:6897259C>A	uc002mfw.2	+	4	376	c.338C>A	c.(337-339)TCT>TAT	p.S113Y	EMR1_uc010dvc.2_Missense_Mutation_p.S113Y|EMR1_uc010dvb.2_Intron|EMR1_uc010xji.1_Intron|EMR1_uc010xjj.1_Missense_Mutation_p.S113Y	NM_001974	NP_001965	Q14246	EMR1_HUMAN	egf-like module containing, mucin-like, hormone	113	Extracellular (Potential).|EGF-like 2; calcium-binding (Potential).				cell adhesion|neuropeptide signaling pathway	integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(3)|lung(1)|skin(1)	5	all_hematologic(4;0.166)					GATGGTTTCTCTTCTCCCACT	0.502			NA											11	38					1.33987e-11	2.0716e-11	0.008291	1	0
ZNF799	90576	broad.mit.edu	37	19	12501876	12501876	+	Nonsense_Mutation	SNP	C	C	A			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr19:12501876C>A	uc010dyt.2	-	4	1486	c.1336G>T	c.(1336-1338)GAG>TAG	p.E446*	ZNF799_uc002mts.3_Intron	NM_001080821	NP_001074290	Q96GE5	ZN799_HUMAN	zinc finger protein 799	446					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(3)|ovary(2)|skin(1)	6						TAGGGTTTCTCTCCAGTATGA	0.383			NA											21	81					2.4624e-09	3.54074e-09	0.008871	1	0
CYP4F2	8529	broad.mit.edu	37	19	15990654	15990654	+	Missense_Mutation	SNP	C	C	A			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr19:15990654C>A	uc002nbs.1	-	10	1219	c.1169G>T	c.(1168-1170)CGG>CTG	p.R390L	CYP4F2_uc010xot.1_Missense_Mutation_p.R241L	NM_001082	NP_001073	P78329	CP4F2_HUMAN	cytochrome P450, family 4, subfamily F,	390					leukotriene metabolic process|long-chain fatty acid metabolic process|very long-chain fatty acid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	alkane 1-monooxygenase activity|electron carrier activity|heme binding|leukotriene-B4 20-monooxygenase activity|oxygen binding|protein binding			ovary(1)|skin(1)	2						GGGATGCAGCCGCAGGCTCTC	0.612			NA											28	137					1.74197e-06	2.20166e-06	0.00632	1	0
FCHO1	23149	broad.mit.edu	37	19	17892527	17892528	+	Nonsense_Mutation	DNP	CC	CC	AA			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr19:17892527_17892528CC>AA	uc010ebb.2	+	22	2024_2025	c.1835_1836CC>AA	c.(1834-1836)TCC>TAA	p.S612*	FCHO1_uc002nhg.3_Nonsense_Mutation_p.S612*|FCHO1_uc002nhh.2_Nonsense_Mutation_p.S612*|FCHO1_uc010xpw.1_Nonsense_Mutation_p.S562*|FCHO1_uc002nhi.2_Nonsense_Mutation_p.S68*|FCHO1_uc002nhj.2_5'UTR	NM_001161358	NP_001154830	O14526	FCHO1_HUMAN	FCH domain only 1 isoform b	612										breast(1)	1						CCAGGAGTCTCCCGGGGTCCGA	0.629			NA											28	129					0	0	0.004672	0	0
ZNF91	7644	broad.mit.edu	37	19	23544912	23544912	+	Missense_Mutation	SNP	C	C	A			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr19:23544912C>A	uc002nre.2	-	4	982	c.869G>T	c.(868-870)GGA>GTA	p.G290V	ZNF91_uc010xrj.1_Missense_Mutation_p.G258V	NM_003430	NP_003421	Q05481	ZNF91_HUMAN	zinc finger protein 91	290						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		all_lung(12;0.0349)|Lung NSC(12;0.0538)|all_epithelial(12;0.0611)				GGGTTTCTCTCCAGTGTGTAT	0.378			NA											8	71					0.000673444	0.000748663	0.008291	1	0
ZNF536	9745	broad.mit.edu	37	19	31040324	31040324	+	Silent	SNP	G	G	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr19:31040324G>T	uc002nsu.1	+	4	3936	c.3798G>T	c.(3796-3798)TCG>TCT	p.S1266S	ZNF536_uc010edd.1_Silent_p.S1266S	NM_014717	NP_055532	O15090	ZN536_HUMAN	zinc finger protein 536	1266					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(7)|large_intestine(2)|skin(2)	11	Esophageal squamous(110;0.0834)					ACATGCTGTCGGTCCTCAGGG	0.587			NA											6	31					0.00198382	0.00216386	0.001984	1	0
SHKBP1	92799	broad.mit.edu	37	19	41086559	41086559	+	Missense_Mutation	SNP	A	A	G			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr19:41086559A>G	uc002oob.2	+	8	699	c.650A>G	c.(649-651)TAC>TGC	p.Y217C	SHKBP1_uc002ooc.2_Missense_Mutation_p.Y217C|SHKBP1_uc002ood.2_Missense_Mutation_p.Y217C|SHKBP1_uc010xvl.1_Missense_Mutation_p.Y140C|SHKBP1_uc002ooe.2_Missense_Mutation_p.Y54C|SHKBP1_uc002oof.2_Missense_Mutation_p.Y54C|SHKBP1_uc010xvm.1_Missense_Mutation_p.Y54C|SHKBP1_uc010xvn.1_Missense_Mutation_p.Y95C	NM_138392	NP_612401	Q8TBC3	SHKB1_HUMAN	SH3KBP1 binding protein 1	217						voltage-gated potassium channel complex	voltage-gated potassium channel activity			ovary(1)|pancreas(1)	2			Lung(22;0.000114)|LUSC - Lung squamous cell carcinoma(20;0.000384)			CTAGTCTGCTACAGGTGCTTG	0.587			NA											8	62					0	0	0.00308	0	0
TMEM145	284339	broad.mit.edu	37	19	42821947	42821947	+	Missense_Mutation	SNP	G	G	C			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr19:42821947G>C	uc002otk.1	+	12	1039	c.987G>C	c.(985-987)TGG>TGC	p.W329C		NM_173633	NP_775904	Q8NBT3	TM145_HUMAN	transmembrane protein 145	329	Helical; (Potential).					integral to membrane					0		Prostate(69;0.00682)				CCTACGTGTGGTTCTGCTATG	0.557			NA											22	77					0	0	0.014323	0	0
ELSPBP1	64100	broad.mit.edu	37	19	48517427	48517427	+	Splice_Site	SNP	G	G	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr19:48517427G>T	uc002pht.2	+	3	226	c.71_splice	c.e3-1	p.G24_splice		NM_022142	NP_071425	Q96BH3	ESPB1_HUMAN	epididymal sperm binding protein 1 precursor						single fertilization	extracellular region					0		all_cancers(25;8.7e-09)|all_lung(116;1.15e-06)|all_epithelial(76;1.17e-06)|Lung NSC(112;2.56e-06)|all_neural(266;0.0138)|Ovarian(192;0.0261)|Breast(70;0.203)		OV - Ovarian serous cystadenocarcinoma(262;0.000253)|all cancers(93;0.00129)|Epithelial(262;0.0314)|GBM - Glioblastoma multiforme(486;0.0606)		CTGCCCTTCAGGGATGCATGA	0.413			NA											40	116					3.7052e-28	6.9418e-28	0.013114	1	0
CD33	945	broad.mit.edu	37	19	51742847	51742847	+	Missense_Mutation	SNP	G	G	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr19:51742847G>T	uc002pwa.2	+	7	1039	c.999G>T	c.(997-999)GAG>GAT	p.E333D	CD33_uc010eos.1_3'UTR|CD33_uc010eot.1_Missense_Mutation_p.E206D|CD33_uc010eou.1_RNA	NM_001772	NP_001763	P20138	CD33_HUMAN	CD33 antigen isoform 1 precursor	333	Cytoplasmic (Potential).				cell adhesion|cell-cell signaling|negative regulation of cell proliferation	external side of plasma membrane|integral to plasma membrane	receptor activity|sugar binding				0		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000224)|OV - Ovarian serous cystadenocarcinoma(262;0.00468)	Gemtuzumab ozogamicin(DB00056)	CTACTGTGGAGATGGATGAGG	0.507			NA											8	44					0.00307968	0.00334771	0.00308	1	0
ZNF578	147660	broad.mit.edu	37	19	53015320	53015320	+	Silent	SNP	C	C	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr19:53015320C>T	uc002pzp.3	+	6	1930	c.1686C>T	c.(1684-1686)AGC>AGT	p.S562S		NM_001099694	NP_001093164	Q96N58	ZN578_HUMAN	zinc finger protein 578	337					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				GBM - Glioblastoma multiforme(134;0.00819)|OV - Ovarian serous cystadenocarcinoma(262;0.01)		GAATTCATAGCGGAGAGAAAC	0.388			NA											8	46					0	0	0.004482	0	0
NLRP12	91662	broad.mit.edu	37	19	54310871	54310871	+	Silent	SNP	C	C	A			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr19:54310871C>A	uc002qch.3	-	4	2341	c.2121G>T	c.(2119-2121)GCG>GCT	p.A707A	NLRP12_uc010eqw.2_5'UTR|NLRP12_uc002qci.3_Silent_p.A707A|NLRP12_uc002qcj.3_Silent_p.A708A|NLRP12_uc002qck.3_RNA|NLRP12_uc010eqx.2_Silent_p.A708A	NM_144687	NP_653288	P59046	NAL12_HUMAN	NLR family, pyrin domain containing 12 isoform	707					negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of interleukin-1 secretion|negative regulation of interleukin-6 biosynthetic process|negative regulation of protein autophosphorylation|negative regulation of Toll signaling pathway|positive regulation of inflammatory response|positive regulation of interleukin-1 beta secretion|regulation of interleukin-18 biosynthetic process|release of cytoplasmic sequestered NF-kappaB	cytoplasm	ATP binding|caspase activator activity|protein binding			ovary(4)|upper_aerodigestive_tract(2)|lung(1)	7	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.026)		TGCACAGGGCCGCTGCCAGAT	0.567			NA											9	45					7.48243e-07	9.64839e-07	0.006214	1	0
LAIR2	3904	broad.mit.edu	37	19	55019118	55019118	+	Missense_Mutation	SNP	G	G	A			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr19:55019118G>A	uc002qgc.2	+	3	205	c.83G>A	c.(82-84)AGA>AAA	p.R28K	LAIR2_uc002qga.1_RNA|LAIR2_uc002qgb.1_RNA|LAIR2_uc002qgd.2_Missense_Mutation_p.R28K|LAIR2_uc010erl.2_Missense_Mutation_p.R28K	NM_002288	NP_002279	Q6ISS4	LAIR2_HUMAN	leukocyte-associated immunoglobulin-like	28						extracellular region	receptor activity			ovary(1)	1	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.0967)		GCCCTTCCCAGACCCTCCATC	0.468			NA											38	156					0	0	0.00623	0	0
LILRB1	10859	broad.mit.edu	37	19	55148268	55148268	+	Missense_Mutation	SNP	C	C	A			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr19:55148268C>A	uc002qgj.2	+	16	2232	c.1892C>A	c.(1891-1893)CCA>CAA	p.P631Q	LILRB1_uc002qgl.2_Missense_Mutation_p.P632Q|LILRB1_uc002qgk.2_Missense_Mutation_p.P632Q|LILRB1_uc002qgm.2_Missense_Mutation_p.P633Q|LILRB1_uc010erq.2_Missense_Mutation_p.P615Q|LILRB1_uc010err.2_RNA	NM_006669	NP_006660	Q8NHL6	LIRB1_HUMAN	leukocyte immunoglobulin-like receptor,	631	Cytoplasmic (Potential).				regulation of immune response|response to virus	integral to membrane|plasma membrane	protein phosphatase 1 binding|receptor activity			large_intestine(1)|ovary(1)|skin(1)	3				GBM - Glioblastoma multiforme(193;0.0188)		GAGCCTCCTCCATCCCAGGAA	0.652			NA								HNSCC(37;0.09)			18	65					8.10497e-08	1.09615e-07	0.010504	1	0
TNNI3	7137	broad.mit.edu	37	19	55665404	55665404	+	Silent	SNP	G	G	A			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr19:55665404G>A	uc002qjg.3	-	7	543	c.543C>T	c.(541-543)ACC>ACT	p.T181T	TNNI3_uc010yft.1_Silent_p.T173T	NM_000363	NP_000354	P19429	TNNI3_HUMAN	troponin I, cardiac	181					cardiac muscle contraction|cellular calcium ion homeostasis|muscle filament sliding|negative regulation of ATPase activity|regulation of systemic arterial blood pressure by ischemic conditions|vasculogenesis|ventricular cardiac muscle tissue morphogenesis	cytosol|troponin complex	actin binding|calcium channel inhibitor activity|calcium-dependent protein binding|protein domain specific binding|protein kinase binding|troponin C binding|troponin T binding			lung(1)|pancreas(1)	2			BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0452)		TCACCTTCTCGGTGTCCTCCT	0.622			NA											24	96					0	0	0.003954	0	0
TNNI3	7137	broad.mit.edu	37	19	55665459	55665459	+	Missense_Mutation	SNP	G	G	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr19:55665459G>T	uc002qjg.3	-	7	488	c.488C>A	c.(487-489)GCT>GAT	p.A163D	TNNI3_uc010yft.1_Missense_Mutation_p.A155D	NM_000363	NP_000354	P19429	TNNI3_HUMAN	troponin I, cardiac	163					cardiac muscle contraction|cellular calcium ion homeostasis|muscle filament sliding|negative regulation of ATPase activity|regulation of systemic arterial blood pressure by ischemic conditions|vasculogenesis|ventricular cardiac muscle tissue morphogenesis	cytosol|troponin complex	actin binding|calcium channel inhibitor activity|calcium-dependent protein binding|protein domain specific binding|protein kinase binding|troponin C binding|troponin T binding			lung(1)|pancreas(1)	2			BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0452)		GGACTCCTTAGCCCGGGCCCC	0.607			NA											16	73					3.32936e-07	4.36379e-07	0.006122	1	0
NLRP4	147945	broad.mit.edu	37	19	56369531	56369531	+	Missense_Mutation	SNP	C	C	G			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr19:56369531C>G	uc002qmd.3	+	3	1194	c.772C>G	c.(772-774)CAG>GAG	p.Q258E	NLRP4_uc002qmf.2_Missense_Mutation_p.Q183E|NLRP4_uc010etf.2_Missense_Mutation_p.Q89E	NM_134444	NP_604393	Q96MN2	NALP4_HUMAN	NLR family, pyrin domain containing 4	258	NACHT.						ATP binding			ovary(5)|skin(4)|lung(3)|upper_aerodigestive_tract(1)|kidney(1)|pancreas(1)	15		Colorectal(82;0.0002)|Ovarian(87;0.221)		GBM - Glioblastoma multiforme(193;0.0606)		ACGGCCGGTGCAGGTGCTTCT	0.577			NA											19	103					0	0	0.007413	0	0
ZNF835	90485	broad.mit.edu	37	19	57175196	57175196	+	Silent	SNP	G	G	A			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr19:57175196G>A	uc010ygo.1	-	2	1437	c.1437C>T	c.(1435-1437)AAC>AAT	p.N479N	ZNF835_uc010ygn.1_Silent_p.N457N	NM_001005850	NP_001005850			zinc finger protein 835											pancreas(3)|skin(1)	4						GGTAGGAGCGGTTGCTGAAGG	0.672			NA											37	110					0	0	0.003271	0	0
ZSCAN22	342945	broad.mit.edu	37	19	58846460	58846460	+	Silent	SNP	C	C	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr19:58846460C>T	uc002qsc.2	+	2	439	c.292C>T	c.(292-294)CTG>TTG	p.L98L	ZSCAN22_uc010yhz.1_Silent_p.L98L	NM_181846	NP_862829	P10073	ZSC22_HUMAN	zinc finger and SCAN domain containing 22	98	SCAN box.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			pancreas(1)	1		all_cancers(17;3.11e-12)|all_epithelial(17;9.43e-09)|Colorectal(82;0.000256)|Lung NSC(17;0.000607)|all_lung(17;0.0024)|all_neural(62;0.0412)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0289)		GGAGCAGTTCCTGGGTGCGCT	0.662			NA											7	49					0	0	0.001984	0	0
MYT1L	23040	broad.mit.edu	37	2	1983535	1983535	+	Silent	SNP	G	G	C			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr2:1983535G>C	uc002qxe.2	-	6	842	c.15C>G	c.(13-15)ACC>ACG	p.T5T	MYT1L_uc002qxd.2_Silent_p.T5T|MYT1L_uc002qxf.1_RNA	NM_015025	NP_055840	Q9UL68	MYT1L_HUMAN	myelin transcription factor 1-like	5					cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(5)|central_nervous_system(1)	6	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.037)|all_epithelial(98;0.241)		OV - Ovarian serous cystadenocarcinoma(76;0.169)|all cancers(51;0.244)		GCTTCTCCTCGGTGTCCACCT	0.617			NA											9	25					0	0	0.006214	0	0
GRHL1	29841	broad.mit.edu	37	2	10126264	10126264	+	Missense_Mutation	SNP	G	G	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr2:10126264G>T	uc002raa.2	+	9	1294	c.1123G>T	c.(1123-1125)GTG>TTG	p.V375L	GRHL1_uc002rab.2_RNA|GRHL1_uc002rad.2_Missense_Mutation_p.V186L|GRHL1_uc010yjb.1_Missense_Mutation_p.V224L	NM_198182	NP_937825	Q9NZI5	GRHL1_HUMAN	grainyhead-like 1	375					cellular lipid metabolic process|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	Golgi apparatus|nucleus	DNA binding			pancreas(1)|skin(1)	2	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.172)|OV - Ovarian serous cystadenocarcinoma(76;0.246)		TTTCATCTCTGTGAACTGCTT	0.423			NA											50	177					1.51926e-22	2.80512e-22	0.01441	1	0
KCNF1	3754	broad.mit.edu	37	2	11053359	11053359	+	Missense_Mutation	SNP	C	C	A			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr2:11053359C>A	uc002rax.2	+	1	1297	c.807C>A	c.(805-807)AGC>AGA	p.S269R		NM_002236	NP_002227	Q9H3M0	KCNF1_HUMAN	potassium voltage-gated channel, subfamily F,	269	Helical; Name=Segment S3; (Potential).					voltage-gated potassium channel complex	voltage-gated potassium channel activity			ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.191)			Epithelial(75;0.115)|OV - Ovarian serous cystadenocarcinoma(76;0.128)		TCTACGTGAGCCTCACGCTCA	0.617			NA											10	42					0.000673444	0.000748663	0.008291	1	0
UBXN2A	165324	broad.mit.edu	37	2	24205881	24205881	+	Nonsense_Mutation	SNP	G	G	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr2:24205881G>T	uc010exy.2	+	6	871	c.403G>T	c.(403-405)GGA>TGA	p.G135*	UBXN2A_uc002rem.2_RNA|UBXN2A_uc002ren.2_Nonsense_Mutation_p.G135*|UBXN2A_uc010ykj.1_Nonsense_Mutation_p.G135*	NM_181713	NP_859064	P68543	UBX2A_HUMAN	UBX domain containing 4	135											0						GCCCTTTTCAGGACAGGGTCA	0.368			NA											11	31					1.5842e-08	2.2326e-08	0.001855	1	0
GPR113	165082	broad.mit.edu	37	2	26569027	26569027	+	Missense_Mutation	SNP	C	C	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr2:26569027C>T	uc010eyk.1	-	1	659	c.76G>A	c.(76-78)GGC>AGC	p.G26S	EPT1_uc010ykz.1_5'UTR|EPT1_uc010eyl.1_RNA|GPR113_uc002rhb.1_5'Flank|GPR113_uc002rhc.1_5'UTR|GPR113_uc002rhd.1_RNA	NM_153835	NP_722577	Q8IZF5	GP113_HUMAN	G-protein coupled receptor 113 isoform 3	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(4)	4	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CTTGCCCAGCCGGTGTGGTGC	0.677			NA											3	18					0	0	0.004672	0	0
PREB	10113	broad.mit.edu	37	2	27355541	27355541	+	Missense_Mutation	SNP	C	C	G			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr2:27355541C>G	uc002rix.1	-	5	935	c.682G>C	c.(682-684)GTG>CTG	p.V228L	PREB_uc002riy.1_Missense_Mutation_p.V156L|PREB_uc002riz.1_RNA|PREB_uc002rja.1_Missense_Mutation_p.V228L	NM_013388	NP_037520	Q9HCU5	PREB_HUMAN	prolactin regulatory element binding protein	228	Cytoplasmic (Potential).|WD 2.				COPII vesicle coating|post-translational protein modification|protein N-linked glycosylation via asparagine|protein transport|regulation of transcription, DNA-dependent|transcription, DNA-dependent	endoplasmic reticulum membrane|integral to membrane|nucleus	DNA binding|guanyl-nucleotide exchange factor activity|protein binding			ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					AGCTGTGTCACCAGCTGATCC	0.532			NA											12	71					0	0	0.013537	0	0
MAP4K3	8491	broad.mit.edu	37	2	39494378	39494378	+	Missense_Mutation	SNP	C	C	A			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr2:39494378C>A	uc002rro.2	-	27	2075	c.1984G>T	c.(1984-1986)GTA>TTA	p.V662L	MAP4K3_uc002rrp.2_Missense_Mutation_p.V641L|MAP4K3_uc010yns.1_Missense_Mutation_p.V215L	NM_003618	NP_003609	Q8IVH8	M4K3_HUMAN	mitogen-activated protein kinase kinase kinase	662	CNH.				JNK cascade		ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			ovary(3)|lung(3)|stomach(1)|pancreas(1)	8		all_hematologic(82;0.211)				TTTGCTGATACAGAAAATTTC	0.249			NA											10	57					0.00829132	0.00883206	0.008291	1	0
SLC8A1	6546	broad.mit.edu	37	2	40656493	40656493	+	Missense_Mutation	SNP	G	G	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr2:40656493G>T	uc002rrx.2	-	1	952	c.928C>A	c.(928-930)CTG>ATG	p.L310M	SLC8A1_uc002rry.2_Missense_Mutation_p.L310M|SLC8A1_uc002rrz.2_Missense_Mutation_p.L310M|SLC8A1_uc002rsa.2_Missense_Mutation_p.L310M|SLC8A1_uc002rsd.3_Missense_Mutation_p.L310M|SLC8A1_uc002rsb.1_Missense_Mutation_p.L310M|SLC8A1_uc010fan.1_Missense_Mutation_p.L310M|SLC8A1_uc002rsc.1_Missense_Mutation_p.L310M	NM_021097	NP_066920	P32418	NAC1_HUMAN	solute carrier family 8 (sodium/calcium	310	Cytoplasmic (Potential).				cell communication|muscle contraction|platelet activation	integral to plasma membrane	calcium:sodium antiporter activity|calmodulin binding|heat shock protein binding			ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	4					Alpha-Linolenic Acid(DB00132)|Icosapent(DB00159)	TCCACCTCCAGAACCAGAGCA	0.423			NA											28	160					2.08973e-25	3.89227e-25	0.005443	1	0
SLC3A1	6519	broad.mit.edu	37	2	44508605	44508605	+	Silent	SNP	A	A	G			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr2:44508605A>G	uc002ruc.3	+	3	768	c.690A>G	c.(688-690)ACA>ACG	p.T230T	SLC3A1_uc002rty.2_Silent_p.T230T|SLC3A1_uc002rtz.2_Silent_p.T230T|SLC3A1_uc002rua.2_Silent_p.T230T|SLC3A1_uc002rub.2_Silent_p.T230T	NM_000341	NP_000332	Q07837	SLC31_HUMAN	solute carrier family 3, member 1	230	Extracellular (Potential).				carbohydrate metabolic process|cellular amino acid metabolic process|ion transport	integral to plasma membrane|membrane fraction	basic amino acid transmembrane transporter activity|catalytic activity|cation binding|L-cystine transmembrane transporter activity				0		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)			L-Cystine(DB00138)	GGACACGGACAGGAAAATATA	0.363			NA											10	22					0	0	0.008291	0	0
FSHR	2492	broad.mit.edu	37	2	49210102	49210102	+	Missense_Mutation	SNP	A	A	G			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr2:49210102A>G	uc002rww.2	-	8	691	c.617T>C	c.(616-618)TTA>TCA	p.L206S	FSHR_uc002rwx.2_Missense_Mutation_p.L206S|FSHR_uc010fbn.2_Missense_Mutation_p.L180S	NM_000145	NP_000136	P23945	FSHR_HUMAN	follicle stimulating hormone receptor isoform 1	206	LRR 7.|Extracellular (Potential).				female gamete generation|male gonad development|spermatogenesis	integral to membrane|plasma membrane	follicle-stimulating hormone receptor activity|protein binding			ovary(4)|lung(2)|central_nervous_system(1)|skin(1)	8		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.181)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)		Choriogonadotropin alfa(DB00097)|Follitropin beta(DB00066)|Menotropins(DB00032)|Urofollitropin(DB00094)	CAATTCTTCTAAATTATTATT	0.408			NA							Gonadal_Dysgenesis_46_XX				10	27					0	0	0.006214	0	0
NRXN1	9378	broad.mit.edu	37	2	50723093	50723093	+	Missense_Mutation	SNP	G	G	A			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr2:50723093G>A	uc010fbq.2	-	15	4617	c.3140C>T	c.(3139-3141)ACA>ATA	p.T1047I	NRXN1_uc002rxb.3_Missense_Mutation_p.T679I|NRXN1_uc002rxe.3_Missense_Mutation_p.T1007I|NRXN1_uc002rxc.1_RNA	NM_001135659	NP_001129131	P58400	NRX1B_HUMAN	neurexin 1 isoform alpha2 precursor	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					angiogenesis|neuron cell-cell adhesion|neuronal signal transduction	cell surface|endocytic vesicle|integral to membrane|presynaptic membrane	cell adhesion molecule binding|receptor binding			ovary(2)	2		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.192)	Lung(47;0.0813)|LUSC - Lung squamous cell carcinoma(58;0.116)			TGTGATTTTTGTGTCAATCTT	0.473			NA											7	36					0	0	0.001984	0	0
COMMD1	150684	broad.mit.edu	37	2	62228008	62228008	+	Missense_Mutation	SNP	G	G	C			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr2:62228008G>C	uc002sbp.2	+	2	364	c.353G>C	c.(352-354)GGG>GCG	p.G118A	COMMD1_uc002sbq.1_RNA	NM_152516	NP_689729	Q8N668	COMD1_HUMAN	MURR1	118	COMM.				copper ion homeostasis|negative regulation of NF-kappaB transcription factor activity|positive regulation of protein ubiquitination|regulation of proteasomal ubiquitin-dependent protein catabolic process	cell junction|Cul2-RING ubiquitin ligase complex|cytoplasm|nucleolus	copper ion binding|protein homodimerization activity			ovary(1)	1	Lung NSC(7;0.035)|all_lung(7;0.0691)		LUSC - Lung squamous cell carcinoma(7;4.73e-07)|Epithelial(17;0.0216)|all cancers(80;0.0934)			TGGAATAGCGGGCTTCGGGGC	0.502			NA											16	49					0	0	0.004007	0	0
OTX1	5013	broad.mit.edu	37	2	63283419	63283419	+	Missense_Mutation	SNP	G	G	A			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr2:63283419G>A	uc002scd.2	+	5	1281	c.1033G>A	c.(1033-1035)GAC>AAC	p.D345N	OTX1_uc010ypt.1_Missense_Mutation_p.D279N	NM_014562	NP_055377	P32242	OTX1_HUMAN	orthodenticle homeobox 1	345						nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			pancreas(2)	2	Lung NSC(7;0.121)|all_lung(7;0.211)					GGACTATAAGGACCAAGCCTC	0.577			NA											8	61					0	0	0.004482	0	0
SPRED2	200734	broad.mit.edu	37	2	65540999	65540999	+	Missense_Mutation	SNP	C	C	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr2:65540999C>T	uc002sdr.3	-	6	1428	c.893G>A	c.(892-894)CGG>CAG	p.R298Q	SPRED2_uc010fcw.2_Missense_Mutation_p.R295Q	NM_181784	NP_861449	Q7Z698	SPRE2_HUMAN	sprouty-related protein with EVH-1 domain 2	298					inactivation of MAPK activity|multicellular organismal development	transport vesicle membrane	stem cell factor receptor binding			ovary(1)|lung(1)|central_nervous_system(1)	3						CTTCCGCCGCCGCGACTTGCC	0.682			NA											30	127					0	0	0.003271	0	0
DUSP11	8446	broad.mit.edu	37	2	74007070	74007070	+	Nonsense_Mutation	SNP	C	C	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr2:74007070C>T	uc002sjp.2	-	1	215	c.173G>A	c.(172-174)TGG>TAG	p.W58*	DUSP11_uc002sjq.3_Nonsense_Mutation_p.W58*	NM_003584	NP_003575	O75319	DUS11_HUMAN	dual specificity phosphatase 11	11					RNA processing	nucleus	protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity|RNA binding			skin(1)	1						TCTCCGGCCCCAGCCACTGCG	0.622			NA									OREG0014714	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	17	79					0	0	0.00499	0	0
MOGS	7841	broad.mit.edu	37	2	74689757	74689757	+	Missense_Mutation	SNP	C	C	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr2:74689757C>T	uc010ffj.2	-	4	1322	c.1159G>A	c.(1159-1161)GAG>AAG	p.E387K	MOGS_uc010ffh.2_Missense_Mutation_p.E112K|MOGS_uc010yrt.1_Missense_Mutation_p.E268K|MOGS_uc010ffi.2_Missense_Mutation_p.E281K	NM_006302	NP_006293	Q13724	MOGS_HUMAN	mannosyl-oligosaccharide glucosidase isoform 1	387	Lumenal (Potential).				oligosaccharide metabolic process|post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane|integral to membrane|membrane fraction	mannosyl-oligosaccharide glucosidase activity				0						AAAACCTGCTCGCCAGAGCTC	0.587			NA											27	177					0	0	0.005443	0	0
RETSAT	54884	broad.mit.edu	37	2	85576626	85576626	+	Missense_Mutation	SNP	C	C	A			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr2:85576626C>A	uc002spd.2	-	5	1069	c.878G>T	c.(877-879)CGA>CTA	p.R293L	RETSAT_uc010fge.2_RNA|RETSAT_uc010ysm.1_Missense_Mutation_p.R232L|RETSAT_uc010fgf.2_Missense_Mutation_p.R84L	NM_017750	NP_060220	Q6NUM9	RETST_HUMAN	all-trans-13,14-dihydroretinol saturase	293					retinol metabolic process	endoplasmic reticulum membrane|nuclear outer membrane	all-trans-retinol 13,14-reductase activity|electron carrier activity			ovary(2)	2					Vitamin A(DB00162)	GGAACCCCCTCGGGGATAAAA	0.577			NA											14	67					3.27435e-08	4.48551e-08	0.00245	1	0
THNSL2	55258	broad.mit.edu	37	2	88474273	88474273	+	Missense_Mutation	SNP	G	G	T	rs149024211		TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr2:88474273G>T	uc002ssz.3	+	3	492	c.339G>T	c.(337-339)AAG>AAT	p.K113N	THNSL2_uc002ssv.2_RNA|THNSL2_uc002ssw.3_Missense_Mutation_p.K113N|THNSL2_uc002ssx.3_Missense_Mutation_p.K81N|THNSL2_uc002sta.3_Intron|THNSL2_uc002ssy.3_Missense_Mutation_p.K113N|THNSL2_uc010fhe.2_Translation_Start_Site	NM_018271	NP_060741	Q86YJ6	THNS2_HUMAN	threonine synthase-like 2	113					threonine biosynthetic process		threonine synthase activity			ovary(1)	1						ATGCATTTAAGGACCTGTCCC	0.522			NA											21	80					4.35082e-09	6.20016e-09	0.010504	1	0
CNGA3	1261	broad.mit.edu	37	2	99013028	99013028	+	Missense_Mutation	SNP	G	G	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr2:99013028G>T	uc002syt.2	+	8	1812	c.1395G>T	c.(1393-1395)AAG>AAT	p.K465N	CNGA3_uc002syu.2_Missense_Mutation_p.K447N|CNGA3_uc010fij.2_Missense_Mutation_p.K469N	NM_001298	NP_001289	Q16281	CNGA3_HUMAN	cyclic nucleotide gated channel alpha 3 isoform	465					signal transduction|visual perception	integral to membrane	cGMP binding			ovary(5)|upper_aerodigestive_tract(1)	6						ACAAGCTGAAGGCTGAGATCG	0.577			NA											14	32					9.31168e-06	1.11705e-05	0.001855	1	0
NPAS2	4862	broad.mit.edu	37	2	101591311	101591311	+	Missense_Mutation	SNP	A	A	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr2:101591311A>T	uc002tap.1	+	13	1473	c.1187A>T	c.(1186-1188)GAC>GTC	p.D396V	NPAS2_uc010yvt.1_Missense_Mutation_p.D461V|NPAS2_uc010fit.1_5'UTR	NM_002518	NP_002509	Q99743	NPAS2_HUMAN	neuronal PAS domain protein 2	396					central nervous system development|positive regulation of transcription from RNA polymerase II promoter|rhythmic process	transcription factor complex	DNA binding|Hsp90 protein binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			ovary(3)|upper_aerodigestive_tract(1)	4						AACACACTCGACGTGGGTGCC	0.527			NA											7	53					0	0	0.001984	0	0
MAP4K4	9448	broad.mit.edu	37	2	102476325	102476325	+	Missense_Mutation	SNP	A	A	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr2:102476325A>T	uc002tbg.2	+	15	1758	c.1703A>T	c.(1702-1704)GAG>GTG	p.E568V	MAP4K4_uc002tbc.2_Missense_Mutation_p.E568V|MAP4K4_uc002tbd.2_Missense_Mutation_p.E537V|MAP4K4_uc002tbe.2_Missense_Mutation_p.E537V|MAP4K4_uc002tbf.2_Missense_Mutation_p.E537V|MAP4K4_uc010yvy.1_Missense_Mutation_p.E537V|MAP4K4_uc002tbh.2_Missense_Mutation_p.E537V|MAP4K4_uc002tbi.2_Missense_Mutation_p.E421V|MAP4K4_uc010yvz.1_Missense_Mutation_p.E517V|MAP4K4_uc002tbk.2_Missense_Mutation_p.E77V|MAP4K4_uc002tbj.1_Missense_Mutation_p.E433V	NM_145687	NP_663720	O95819	M4K4_HUMAN	mitogen-activated protein kinase kinase kinase	568					intracellular protein kinase cascade|regulation of JNK cascade|response to stress	cytoplasm	ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			stomach(1)|lung(1)|central_nervous_system(1)|skin(1)	4						CGAGCGCGAGAGGTATCCTCT	0.483			NA											3	12					0	0	0.004672	0	0
ACOXL	55289	broad.mit.edu	37	2	111850528	111850528	+	Silent	SNP	G	G	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr2:111850528G>T	uc002tgr.3	+	18	1841	c.1617G>T	c.(1615-1617)ACG>ACT	p.T539T	ACOXL_uc010fkc.2_Silent_p.T509T|ACOXL_uc010yxk.1_Silent_p.T509T	NM_001105516	NP_001098986	Q9NUZ1	ACOXL_HUMAN	acyl-Coenzyme A oxidase-like 2	539					fatty acid beta-oxidation	peroxisome	acyl-CoA dehydrogenase activity|acyl-CoA oxidase activity				0						TGGCCAGCACGAGGATCAGGA	0.483			NA											14	60					4.3838e-07	5.7223e-07	0.001855	1	0
CNTNAP5	129684	broad.mit.edu	37	2	125521700	125521700	+	Missense_Mutation	SNP	G	G	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr2:125521700G>T	uc002tno.2	+	16	2870	c.2506G>T	c.(2506-2508)GAC>TAC	p.D836Y	CNTNAP5_uc010flu.2_Missense_Mutation_p.D837Y	NM_130773	NP_570129	Q8WYK1	CNTP5_HUMAN	contactin associated protein-like 5 precursor	836	Laminin G-like 3.|Extracellular (Potential).				cell adhesion|signal transduction	integral to membrane	receptor binding			ovary(10)	10				BRCA - Breast invasive adenocarcinoma(221;0.248)		TGGCATTAAAGACTTCATTCG	0.313			NA											16	68					1.02788e-11	1.59309e-11	0.00499	1	0
MYO7B	4648	broad.mit.edu	37	2	128324281	128324281	+	Nonsense_Mutation	SNP	G	G	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr2:128324281G>T	uc002top.2	+	5	402	c.349G>T	c.(349-351)GAG>TAG	p.E117*		NM_001080527	NP_001073996	Q6PIF6	MYO7B_HUMAN	myosin VIIB	117	Myosin head-like.					apical plasma membrane|myosin complex	actin binding|ATP binding|motor activity			ovary(1)|pancreas(1)	2	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0753)		CTACACCCTGGAGCAGGTACA	0.592			NA											6	20					0.00116845	0.00128549	0.001168	1	0
NCKAP5	344148	broad.mit.edu	37	2	133541991	133541991	+	Missense_Mutation	SNP	T	T	C			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr2:133541991T>C	uc002ttp.2	-	14	2767	c.2393A>G	c.(2392-2394)CAA>CGA	p.Q798R	NCKAP5_uc002ttq.2_Intron	NM_207363	NP_997246	O14513	NCKP5_HUMAN	Nck-associated protein 5 isoform 1	798							protein binding				0						TGTCAGATTTTGCTTTTGATA	0.468			NA											36	162					0	0	0.003755	0	0
KYNU	8942	broad.mit.edu	37	2	143715264	143715264	+	Silent	SNP	C	C	A	rs147103103		TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr2:143715264C>A	uc002tvl.2	+	7	692	c.562C>A	c.(562-564)CGG>AGG	p.R188R	KYNU_uc002tvk.2_Silent_p.R188R|KYNU_uc010fnm.2_Silent_p.R188R	NM_003937	NP_003928	Q16719	KYNU_HUMAN	kynureninase (L-kynurenine hydrolase) isoform a	188					anthranilate metabolic process|NAD biosynthetic process|quinolinate biosynthetic process|response to interferon-gamma|response to vitamin B6	cytosol|mitochondrion|soluble fraction	kynureninase activity|protein homodimerization activity			skin(2)	2				BRCA - Breast invasive adenocarcinoma(221;0.072)	L-Alanine(DB00160)|Pyridoxal Phosphate(DB00114)	AGAAAGTATGCGGATGATAAA	0.308			NA											10	24					2.80697e-09	4.01807e-09	0.010729	1	0
TTN	7273	broad.mit.edu	37	2	179446892	179446892	+	Silent	SNP	G	G	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr2:179446892G>T	uc010zfg.1	-	264	58724	c.58500C>A	c.(58498-58500)ACC>ACA	p.T19500T	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Silent_p.T13195T|TTN_uc010zfi.1_Silent_p.T13128T|TTN_uc010zfj.1_Silent_p.T13003T	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	20427							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TGTGATCTTTGGTTATGTTGC	0.433			NA											15	93					3.27435e-08	4.48551e-08	0.00245	1	0
TTN	7273	broad.mit.edu	37	2	179455328	179455328	+	Missense_Mutation	SNP	G	G	C			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr2:179455328G>C	uc010zfg.1	-	253	53644	c.53420C>G	c.(53419-53421)CCT>CGT	p.P17807R	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.P11502R|TTN_uc010zfi.1_Missense_Mutation_p.P11435R|TTN_uc010zfj.1_Missense_Mutation_p.P11310R	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	18734							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AGGATTAATAGGTGGTCCAGG	0.448			NA											19	113					0	0	0.012319	0	0
ZNF804A	91752	broad.mit.edu	37	2	185800718	185800718	+	Nonsense_Mutation	SNP	C	C	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr2:185800718C>T	uc002uph.2	+	4	1189	c.595C>T	c.(595-597)CAA>TAA	p.Q199*		NM_194250	NP_919226	Q7Z570	Z804A_HUMAN	zinc finger protein 804A	199						intracellular	zinc ion binding			ovary(6)|skin(3)|large_intestine(1)|pancreas(1)	11						AAAAAATAACCAAGTTGGGGA	0.398			NA											5	53					0	0	0.000602	0	0
PGAP1	80055	broad.mit.edu	37	2	197712671	197712671	+	Missense_Mutation	SNP	C	C	A			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr2:197712671C>A	uc002utw.2	-	21	2066	c.1952G>T	c.(1951-1953)GGG>GTG	p.G651V	PGAP1_uc002utx.2_Missense_Mutation_p.G477V|PGAP1_uc002uty.1_3'UTR|PGAP1_uc010fsi.2_5'Flank	NM_024989	NP_079265	Q75T13	PGAP1_HUMAN	GPI deacylase	651	Helical; (Potential).				attachment of GPI anchor to protein|C-terminal protein lipidation|intracellular protein transport|myo-inositol transport	integral to membrane|intrinsic to endoplasmic reticulum membrane	nuclease activity|phosphoric ester hydrolase activity			ovary(3)|central_nervous_system(1)	4						TAAAACTTACCCCAACAGAAA	0.294			NA											4	34					0.00909568	0.00960854	0.009096	1	0
ANKRD44	91526	broad.mit.edu	37	2	197878371	197878372	+	Missense_Mutation	DNP	CC	CC	AA			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr2:197878371_197878372CC>AA	uc002uua.1	-	18	1789_1790	c.1712_1713GG>TT	c.(1711-1713)AGG>ATT	p.R571I	ANKRD44_uc002utz.3_Missense_Mutation_p.R303I	NM_153697	NP_710181	Q8N8A2	ANR44_HUMAN	ankyrin repeat domain 44	596							protein binding			ovary(4)|skin(1)	5			OV - Ovarian serous cystadenocarcinoma(117;0.246)			CTTTCTCATCCCTGATGTCCAG	0.52			NA											32	200					0	0	0.004672	0	0
SF3B1	23451	broad.mit.edu	37	2	198274687	198274687	+	Silent	SNP	A	A	G			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr2:198274687A>G	uc002uue.2	-	7	759	c.711T>C	c.(709-711)GGT>GGC	p.G237G		NM_012433	NP_036565	O75533	SF3B1_HUMAN	splicing factor 3b, subunit 1 isoform 1	237	Interaction with PPP1R8.				nuclear mRNA splicing, via spliceosome	catalytic step 2 spliceosome|nuclear speck|U12-type spliceosomal complex	protein binding			pancreas(3)|ovary(1)|breast(1)|skin(1)	6			OV - Ovarian serous cystadenocarcinoma(117;0.246)			CCTTTGCACGACCTGGTGTCT	0.473			NA											18	69					0	0	0.006122	0	0
ZDBF2	57683	broad.mit.edu	37	2	207174855	207174855	+	Missense_Mutation	SNP	T	T	C			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr2:207174855T>C	uc002vbp.2	+	5	5853	c.5603T>C	c.(5602-5604)GTT>GCT	p.V1868A		NM_020923	NP_065974	Q9HCK1	ZDBF2_HUMAN	zinc finger, DBF-type containing 2	1868							nucleic acid binding|zinc ion binding			ovary(3)	3						ACCAAAAAAGTTTCTTCGAAG	0.413			NA											5	42					0	0	0.000602	0	0
ZDBF2	57683	broad.mit.edu	37	2	207176110	207176110	+	Missense_Mutation	SNP	G	G	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr2:207176110G>T	uc002vbp.2	+	5	7108	c.6858G>T	c.(6856-6858)ATG>ATT	p.M2286I		NM_020923	NP_065974	Q9HCK1	ZDBF2_HUMAN	zinc finger, DBF-type containing 2	2286							nucleic acid binding|zinc ion binding			ovary(3)	3						CAAGCGCTATGGCAAATCCTC	0.507			NA											3	17					0.004672	0.00501021	0.004672	1	0
MAP2	4133	broad.mit.edu	37	2	210560641	210560641	+	Silent	SNP	C	C	G			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr2:210560641C>G	uc002vde.1	+	7	3995	c.3747C>G	c.(3745-3747)CTC>CTG	p.L1249L	MAP2_uc002vdc.1_Silent_p.L1249L|MAP2_uc002vdd.1_Intron|MAP2_uc002vdf.1_Intron|MAP2_uc002vdg.1_Intron|MAP2_uc002vdh.1_Intron|MAP2_uc002vdi.1_Silent_p.L1245L	NM_002374	NP_002365	P11137	MAP2_HUMAN	microtubule-associated protein 2 isoform 1	1249					central nervous system neuron development|dendrite morphogenesis|negative regulation of microtubule depolymerization	cytoplasm|microtubule|microtubule associated complex	beta-dystroglycan binding|calmodulin binding|structural molecule activity			ovary(9)|upper_aerodigestive_tract(2)|large_intestine(2)|pancreas(2)|central_nervous_system(1)|skin(1)	17		Hepatocellular(293;0.137)|Lung NSC(271;0.163)|Renal(323;0.202)		UCEC - Uterine corpus endometrioid carcinoma (47;6.64e-05)|Epithelial(149;3.12e-100)|all cancers(144;6.88e-91)|Lung(261;0.0624)|LUSC - Lung squamous cell carcinoma(261;0.0662)|STAD - Stomach adenocarcinoma(1183;0.18)	Estramustine(DB01196)	ATAAACTGCTCTTCCGCTCAG	0.483	Pancreas(27;423 979 28787 29963)		NA											11	65					0	0	0.008291	0	0
MYL1	4632	broad.mit.edu	37	2	211163206	211163206	+	Missense_Mutation	SNP	G	G	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr2:211163206G>T	uc002vec.2	-	3	371	c.242C>A	c.(241-243)GCT>GAT	p.A81D	MYL1_uc002veb.2_Missense_Mutation_p.A37D	NM_079420	NP_524144	P05976	MYL1_HUMAN	fast skeletal myosin alkali light chain 1	81	EF-hand 1.				muscle filament sliding|muscle organ development	cytosol|muscle myosin complex|sarcomere	calcium ion binding|structural constituent of muscle			ovary(1)	1				Epithelial(149;0.00573)|Lung(261;0.0422)|LUSC - Lung squamous cell carcinoma(261;0.0444)|all cancers(144;0.057)		TGTGCCCAGAGCTCGAAGGAC	0.463			NA											10	96					2.17888e-05	2.55607e-05	0.006214	1	0
ERBB4	2066	broad.mit.edu	37	2	212537946	212537946	+	Silent	SNP	C	C	A			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr2:212537946C>A	uc002veg.1	-	14	1757	c.1659G>T	c.(1657-1659)GTG>GTT	p.V553V	ERBB4_uc002veh.1_Silent_p.V553V|ERBB4_uc010zji.1_Silent_p.V553V|ERBB4_uc010zjj.1_Silent_p.V553V|ERBB4_uc010fut.1_Silent_p.V553V	NM_005235	NP_005226	Q15303	ERBB4_HUMAN	v-erb-a erythroblastic leukemia viral oncogene	553	Extracellular (Potential).|Cys-rich.				cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent|transmembrane receptor protein tyrosine kinase signaling pathway	basolateral plasma membrane|cytoplasm|integral to membrane|nucleus	ATP binding|protein binding|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			lung(21)|skin(5)|stomach(2)|breast(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	33		Renal(323;0.06)|Lung NSC(271;0.197)		UCEC - Uterine corpus endometrioid carcinoma (47;0.214)|Epithelial(149;5.86e-06)|all cancers(144;2.95e-05)|Lung(261;0.00244)|LUSC - Lung squamous cell carcinoma(224;0.00266)		GGTCACACTCCACACAGATGG	0.468			NA								TSP Lung(8;0.080)			13	76					2.62699e-14	4.3921e-14	0.003163	1	0
CXCR2	3579	broad.mit.edu	37	2	218999542	218999542	+	Missense_Mutation	SNP	G	G	A			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr2:218999542G>A	uc002vgz.1	+	4	243	c.18G>A	c.(16-18)ATG>ATA	p.M6I	CXCR2_uc002vha.1_Missense_Mutation_p.M6I|CXCR2_uc002vhb.1_Missense_Mutation_p.M6I	NM_001557	NP_001548	P25025	CXCR2_HUMAN	interleukin 8 receptor beta	6	Extracellular (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|cellular defense response|dendritic cell chemotaxis|inflammatory response|neutrophil activation|neutrophil chemotaxis|positive regulation of cell proliferation	cell surface|integral to plasma membrane|mast cell granule	interleukin-8 receptor activity			lung(1)|breast(1)	2						ATTTTAACATGGAGAGTGACA	0.403			NA											11	91					0	0	0.008291	0	0
DOCK10	55619	broad.mit.edu	37	2	225729643	225729643	+	Silent	SNP	T	T	C			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr2:225729643T>C	uc010fwz.1	-	12	1658	c.1419A>G	c.(1417-1419)AGA>AGG	p.R473R	DOCK10_uc002vob.2_Silent_p.R467R|DOCK10_uc002vod.1_Silent_p.R473R	NM_014689	NP_055504	Q96BY6	DOC10_HUMAN	dedicator of cytokinesis 10	473							GTP binding			ovary(2)	2		Renal(207;0.0113)|all_lung(227;0.0486)|Lung NSC(271;0.0653)|all_hematologic(139;0.14)		Epithelial(121;2.37e-10)|all cancers(144;2.26e-07)|Lung(261;0.0143)|LUSC - Lung squamous cell carcinoma(224;0.0178)		CTTCTGATTGTCTTGGAGTGA	0.448			NA											8	199					0	0	0.006214	0	0
SPHKAP	80309	broad.mit.edu	37	2	228884712	228884712	+	Silent	SNP	A	A	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr2:228884712A>T	uc002vpq.2	-	7	905	c.858T>A	c.(856-858)TCT>TCA	p.S286S	SPHKAP_uc002vpp.2_Silent_p.S286S|SPHKAP_uc010zlx.1_Silent_p.S286S	NM_001142644	NP_001136116	Q2M3C7	SPKAP_HUMAN	sphingosine kinase type 1-interacting protein	286						cytoplasm	protein binding			skin(5)|ovary(4)|lung(1)	10		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;8.17e-11)|all cancers(144;7.92e-08)|Lung(261;0.0168)|LUSC - Lung squamous cell carcinoma(224;0.0232)		GGTTTTCTGGAGATCGTTCTG	0.443			NA											24	198					0	0	0.00278	0	0
SDCBP2	27111	broad.mit.edu	37	20	1298980	1298980	+	Missense_Mutation	SNP	C	C	G			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr20:1298980C>G	uc002wev.3	-	4	336	c.207G>C	c.(205-207)CAG>CAC	p.Q69H	FKBP1A_uc010gac.2_Missense_Mutation_p.Q69H|SDCBP2_uc010zpq.1_Missense_Mutation_p.Q69H	NM_080489	NP_536737	Q9H190	SDCB2_HUMAN	syndecan binding protein 2 isoform a	69				Q -> H (in Ref. 2; CAC21716).	intracellular signal transduction|intracellular transport|nervous system development	cytoplasm	protein C-terminus binding|protein heterodimerization activity|protein homodimerization activity			large_intestine(1)|skin(1)	2						CCTCTGGAATCTGAAGCAGGC	0.493			NA											10	40					0	0	0.013537	0	0
FASTKD5	60493	broad.mit.edu	37	20	3128895	3128895	+	Missense_Mutation	SNP	C	C	G			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr20:3128895C>G	uc002whz.2	-	2	1133	c.822G>C	c.(820-822)AAG>AAC	p.K274N	uc002whv.1_Intron|UBOX5_uc002whw.2_Intron|UBOX5_uc002whx.2_Intron|UBOX5_uc002why.1_Intron	NM_021826	NP_068598	Q7L8L6	FAKD5_HUMAN	FAST kinase domains 5	274					apoptosis|cellular respiration	mitochondrion	ATP binding|protein kinase activity				0						AGGATAGATCCTTCCAGTGCA	0.383			NA											13	47					0	0	0.013537	0	0
FLRT3	23767	broad.mit.edu	37	20	14307338	14307338	+	Missense_Mutation	SNP	T	T	C			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr20:14307338T>C	uc002wov.1	-	3	1282	c.815A>G	c.(814-816)CAG>CGG	p.Q272R	MACROD2_uc002wot.2_Intron|MACROD2_uc002wou.2_Intron|FLRT3_uc002wow.1_Missense_Mutation_p.Q272R	NM_198391	NP_938205	Q9NZU0	FLRT3_HUMAN	fibronectin leucine rich transmembrane protein 3	272	Extracellular (Potential).|LRR 10.				cell adhesion	integral to plasma membrane|proteinaceous extracellular matrix	protein binding, bridging|receptor signaling protein activity			kidney(1)	1		Colorectal(1;0.0464)	COAD - Colon adenocarcinoma(2;0.129)	Colorectal(1;0.0393)		TCGATAGAGCTGCCTTAGATA	0.403			NA											16	52					0	0	0.004007	0	0
FRG1B	284802	broad.mit.edu	37	20	29625877	29625877	+	Missense_Mutation	SNP	G	G	A	rs7266938	by1000genomes	TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr20:29625877G>A	uc010ztl.1	+	2	63	c.31G>A	c.(31-33)GCC>ACC	p.A11T	FRG1B_uc002wvm.1_RNA|FRG1B_uc010ztj.1_RNA|FRG1B_uc010gdr.1_RNA|FRG1B_uc010ztk.1_Intron					Homo sapiens cDNA FLJ32537 fis, clone SMINT2000400, highly similar to Homo sapiens FRG1 mRNA.												0						GTACAGAATCGCCCTGAAATC	0.353			NA											3	39					0	0	0.009096	0	0
PPP1R16B	26051	broad.mit.edu	37	20	37546820	37546820	+	Silent	SNP	C	C	G	rs138542212	by1000genomes	TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr20:37546820C>G	uc002xje.2	+	11	1404	c.1215C>G	c.(1213-1215)CCC>CCG	p.P405P	PPP1R16B_uc010ggc.2_Silent_p.P363P	NM_015568	NP_056383	Q96T49	PP16B_HUMAN	protein phosphatase 1 regulatory inhibitor	405					regulation of filopodium assembly|signal transduction	nucleus|plasma membrane	protein phosphatase binding			upper_aerodigestive_tract(1)|kidney(1)|skin(1)	3		Myeloproliferative disorder(115;0.00878)				TGGAGAAGCCCGTGCTACTCT	0.537			NA											36	133					0	0	0.004878	0	0
TOX2	84969	broad.mit.edu	37	20	42680134	42680134	+	Silent	SNP	C	C	A			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr20:42680134C>A	uc002xlf.3	+	4	644	c.627C>A	c.(625-627)ACC>ACA	p.T209T	TOX2_uc010ggo.2_Silent_p.T200T|TOX2_uc002xle.3_Silent_p.T158T|TOX2_uc010ggp.2_Silent_p.T158T|TOX2_uc002xlg.2_Silent_p.T158T|TOX2_uc010zwk.1_Silent_p.T78T	NM_001098798	NP_001092268	Q96NM4	TOX2_HUMAN	TOX high mobility group box family member 2	209					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(1)	1		Myeloproliferative disorder(115;0.00452)	COAD - Colon adenocarcinoma(18;0.00189)			AGTCAGCGACCCCCTCTCCCT	0.627			NA											8	24					0.00448238	0.00485591	0.004482	1	0
PDE9A	5152	broad.mit.edu	37	21	44152188	44152188	+	Missense_Mutation	SNP	G	G	A			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr21:44152188G>A	uc002zbm.2	+	6	514	c.451G>A	c.(451-453)GAA>AAA	p.E151K	PDE9A_uc002zbn.2_Missense_Mutation_p.E24K|PDE9A_uc002zbo.2_Intron|PDE9A_uc002zbp.2_5'UTR|PDE9A_uc002zbq.2_Intron|PDE9A_uc002zbs.2_Intron|PDE9A_uc002zbr.2_5'UTR|PDE9A_uc002zbt.2_Intron|PDE9A_uc002zbu.2_Intron|PDE9A_uc002zbv.2_Intron|PDE9A_uc002zbw.2_Intron|PDE9A_uc002zbx.2_Missense_Mutation_p.E91K|PDE9A_uc002zby.2_Intron|PDE9A_uc002zbz.2_Missense_Mutation_p.E43K|PDE9A_uc002zca.2_Missense_Mutation_p.E110K|PDE9A_uc002zcb.2_Missense_Mutation_p.E125K|PDE9A_uc002zcc.2_Missense_Mutation_p.E50K|PDE9A_uc002zcd.2_Missense_Mutation_p.E65K|PDE9A_uc002zce.2_Missense_Mutation_p.E84K|PDE9A_uc002zcf.2_Intron|PDE9A_uc002zcg.2_5'UTR|PDE9A_uc002zch.2_5'UTR	NM_002606	NP_002597	O76083	PDE9A_HUMAN	phosphodiesterase 9A isoform a	151					platelet activation|signal transduction	cytosol|endoplasmic reticulum|Golgi apparatus|perinuclear region of cytoplasm|ruffle membrane	3',5'-cyclic-GMP phosphodiesterase activity|metal ion binding|protein binding			ovary(1)|skin(1)	2						AGAGAGAGAAGAATTAATCCA	0.488			NA											9	27					0	0	0.008291	0	0
NDUFV3	4731	broad.mit.edu	37	21	44317035	44317035	+	Splice_Site	SNP	A	A	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr21:44317035A>T	uc002zcn.2	+	2	115	c.49_splice	c.e2-2	p.T17_splice	NDUFV3_uc002zcm.2_Splice_Site_p.T17_splice	NM_001001503	NP_001001503	P56181	NDUV3_HUMAN	NADH-ubiquinone oxidoreductase flavoprotein 3						mitochondrial electron transport, NADH to ubiquinone|transport	mitochondrial respiratory chain complex I|nucleus	NADH dehydrogenase (ubiquinone) activity			ovary(2)	2				STAD - Stomach adenocarcinoma(101;0.0606)	NADH(DB00157)	TTCTTTTGTCAGACTATGCTC	0.343			NA											3	57					0	0	0.001168	0	0
AIRE	326	broad.mit.edu	37	21	45711088	45711088	+	Silent	SNP	C	C	A			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr21:45711088C>A	uc002zei.2	+	8	1117	c.990C>A	c.(988-990)ATC>ATA	p.I330I	AIRE_uc010gpq.2_RNA|AIRE_uc002zej.2_Silent_p.I133I|AIRE_uc010gpr.2_Silent_p.I133I	NM_000383	NP_000374	O43918	AIRE_HUMAN	autoimmune regulator isoform 1	330	PHD-type 1.				positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	chromatin binding|histone binding|transcription regulatory region DNA binding|translation regulator activity|zinc ion binding			skin(1)	1				Colorectal(79;0.0806)		TCCGGGAGATCCCCAGGTGAG	0.701			NA							Autoimmune_PolyEndocrinopathy_Candidiasis_Ectodermal_Dystrophy				10	24					0.00621372	0.00663005	0.006214	1	0
MCM5	4174	broad.mit.edu	37	22	35809931	35809931	+	Silent	SNP	A	A	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr22:35809931A>T	uc003anu.3	+	9	1249	c.1155A>T	c.(1153-1155)ACA>ACT	p.T385T	MCM5_uc010gwr.2_Silent_p.T194T|MCM5_uc003anv.3_Silent_p.T342T|MCM5_uc010gws.1_Intron|MCM5_uc003anw.1_Silent_p.T169T	NM_006739	NP_006730	P33992	MCM5_HUMAN	minichromosome maintenance complex component 5	385	MCM.|ATP (Potential).				cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	MCM complex	ATP binding|DNA binding|helicase activity|protein binding			ovary(1)	1						ACCCTGGGACAGCCAAGTCCC	0.577			NA											9	52					0	0	0.006214	0	0
MLC1	23209	broad.mit.edu	37	22	50518354	50518354	+	Missense_Mutation	SNP	G	G	C			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr22:50518354G>C	uc003bjg.1	-	5	689	c.416C>G	c.(415-417)GCA>GGA	p.A139G	MLC1_uc011arl.1_Intron|MLC1_uc003bjh.1_Missense_Mutation_p.A139G|MLC1_uc011arm.1_Missense_Mutation_p.A109G|MLC1_uc011arn.1_Missense_Mutation_p.A60G|MLC1_uc011aro.1_Intron	NM_139202	NP_631941	Q15049	MLC1_HUMAN	megalencephalic leukoencephalopathy with	139						basolateral plasma membrane|endosome|integral to membrane|integral to membrane of membrane fraction	ion channel activity			pancreas(1)	1		all_cancers(38;7.69e-11)|all_epithelial(38;9.52e-10)|all_lung(38;3.67e-05)|Breast(42;0.000776)|Lung NSC(38;0.000946)|Ovarian(80;0.0365)|Lung SC(80;0.113)		READ - Rectum adenocarcinoma(2;0.000669)|Colorectal(2;0.00242)|LUAD - Lung adenocarcinoma(64;0.0695)|BRCA - Breast invasive adenocarcinoma(115;0.216)		CACGTTTATTGCTGATGGGTT	0.463			NA											18	63					0	0	0.008871	0	0
HDAC11	79885	broad.mit.edu	37	3	13546070	13546070	+	Missense_Mutation	SNP	A	A	G			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr3:13546070A>G	uc003bxy.2	+	10	1064	c.931A>G	c.(931-933)ATC>GTC	p.I311V	HDAC11_uc010heb.2_3'UTR|HDAC11_uc011aux.1_Missense_Mutation_p.I119V|HDAC11_uc011auy.1_Missense_Mutation_p.I260V	NM_024827	NP_079103	Q96DB2	HDA11_HUMAN	histone deacetylase 11 isoform 1	311	Histone deacetylase.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	histone deacetylase complex|plasma membrane	histone deacetylase activity (H3-K16 specific)|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|transcription factor binding			ovary(2)	2						CACAGCCCGCATCATTGCTGA	0.612			NA											7	65					0	0	0.001984	0	0
WNT7A	7476	broad.mit.edu	37	3	13896107	13896107	+	Missense_Mutation	SNP	C	C	A			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr3:13896107C>A	uc003bye.1	-	3	797	c.492G>T	c.(490-492)AAG>AAT	p.K164N		NM_004625	NP_004616	O00755	WNT7A_HUMAN	wingless-type MMTV integration site family,	164					activation of JUN kinase activity|anterior/posterior pattern formation|canonical Wnt receptor signaling pathway|cell proliferation in forebrain|cellular response to transforming growth factor beta stimulus|central nervous system vasculogenesis|cerebellar granule cell differentiation|dorsal/ventral pattern formation|embryonic axis specification|embryonic digit morphogenesis|embryonic forelimb morphogenesis|embryonic leg morphogenesis|lens fiber cell development|negative regulation of neurogenesis|palate development|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of epithelial cell proliferation involved in wound healing|positive regulation of JNK cascade|positive regulation of synaptogenesis|positive regulation of transcription from RNA polymerase II promoter|regulation of axon diameter|satellite cell activation|satellite cell maintenance involved in skeletal muscle regeneration|sex differentiation|uterus development|Wnt receptor signaling pathway involved in wound healing, spreading of epidermal cells|Wnt receptor signaling pathway, calcium modulating pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	cytokine activity|frizzled binding|receptor agonist activity|signal transducer activity			ovary(2)|breast(1)	3						CCACAAAGACCTTGGCGAAGC	0.612			NA											15	184					3.27435e-08	4.48551e-08	0.00245	1	0
C3orf20	84077	broad.mit.edu	37	3	14798940	14798940	+	Missense_Mutation	SNP	T	T	G			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr3:14798940T>G	uc003byy.2	+	13	2407	c.2003T>G	c.(2002-2004)CTG>CGG	p.L668R	C3orf20_uc003byz.2_Missense_Mutation_p.L546R|C3orf20_uc003bza.2_Missense_Mutation_p.L546R|C3orf20_uc003bzb.1_Missense_Mutation_p.L169R|C3orf20_uc011avj.1_5'UTR	NM_032137	NP_115513	Q8ND61	CC020_HUMAN	hypothetical protein LOC84077	668						cytoplasm|integral to membrane				ovary(3)|skin(1)	4						GACTGCCCGCTGGTGCTGCGG	0.672			NA											13	46					0	0	0.013537	0	0
ZFYVE20	64145	broad.mit.edu	37	3	15116382	15116382	+	Missense_Mutation	SNP	C	C	A	rs139040870		TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr3:15116382C>A	uc003bzm.1	-	14	1876	c.1262G>T	c.(1261-1263)CGA>CTA	p.R421L	ZFYVE20_uc010hek.1_Missense_Mutation_p.R421L	NM_022340	NP_071735	Q9H1K0	RBNS5_HUMAN	FYVE-finger-containing Rab5 effector protein	421	Necessary for the interaction with RAB4A.|Necessary for the interaction with EHD1.				blood coagulation|endosome transport|protein transport	early endosome membrane|plasma membrane	protein binding|zinc ion binding			skin(2)	2						GTTGGCCGCTCGAGAAGCCAG	0.632			NA											9	63					1.58986e-06	2.01341e-06	0.008291	1	0
COLQ	8292	broad.mit.edu	37	3	15499779	15499779	+	Missense_Mutation	SNP	T	T	C			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr3:15499779T>C	uc003bzx.2	-	13	994	c.868A>G	c.(868-870)AGA>GGA	p.R290G	COLQ_uc003bzv.2_Missense_Mutation_p.R280G|COLQ_uc003bzz.2_Missense_Mutation_p.R281G|COLQ_uc010heo.2_Missense_Mutation_p.R256G|COLQ_uc003cac.1_RNA|COLQ_uc003cae.1_Missense_Mutation_p.R149G|COLQ_uc003cad.1_RNA	NM_005677	NP_005668	Q9Y215	COLQ_HUMAN	acetylcholinesterase collagen-like tail subunit	290	Collagen-like 2.				acetylcholine catabolic process in synaptic cleft|asymmetric protein localization	basal lamina|cell junction|collagen|extracellular space|synaptic cleft					0						CAAAGACATCTTCCTGGAGGC	0.507			NA											14	72					0	0	0.00245	0	0
KCNH8	131096	broad.mit.edu	37	3	19575454	19575454	+	Missense_Mutation	SNP	T	T	A			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr3:19575454T>A	uc003cbk.1	+	16	3382	c.3187T>A	c.(3187-3189)TTC>ATC	p.F1063I	KCNH8_uc010hex.1_Missense_Mutation_p.F524I	NM_144633	NP_653234	Q96L42	KCNH8_HUMAN	potassium voltage-gated channel, subfamily H,	1063	Ser-rich.|Cytoplasmic (Potential).					integral to membrane	two-component sensor activity			lung(4)|ovary(1)	5						TGTGAGTTCCTTCAGTCTGGA	0.483	NSCLC(124;1625 1765 8018 24930 42026)		NA											9	70					0	0	0.004482	0	0
MYRIP	25924	broad.mit.edu	37	3	39942332	39942332	+	Missense_Mutation	SNP	G	G	A			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr3:39942332G>A	uc003cka.2	+	2	160	c.25G>A	c.(25-27)GGT>AGT	p.G9S	MYRIP_uc010hhu.2_RNA|MYRIP_uc010hhv.2_Missense_Mutation_p.G9S|MYRIP_uc010hhw.2_5'UTR|MYRIP_uc010hhx.1_Missense_Mutation_p.G9S	NM_015460	NP_056275	Q8NFW9	MYRIP_HUMAN	myosin VIIA and Rab interacting protein	9	RabBD.				intracellular protein transport		actin binding|zinc ion binding			ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	5				KIRC - Kidney renal clear cell carcinoma(284;0.174)|Kidney(284;0.206)		GGACCTGTCTGGTTTGACTGA	0.418			NA											19	91					0	0	0.00278	0	0
COL7A1	1294	broad.mit.edu	37	3	48628953	48628953	+	Missense_Mutation	SNP	G	G	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr3:48628953G>T	uc003ctz.2	-	12	1581	c.1580C>A	c.(1579-1581)TCC>TAC	p.S527Y		NM_000094	NP_000085	Q02388	CO7A1_HUMAN	alpha 1 type VII collagen precursor	527	Fibronectin type-III 4.|Nonhelical region (NC1).				cell adhesion|epidermis development	basement membrane|collagen type VII	protein binding|serine-type endopeptidase inhibitor activity			ovary(4)|breast(3)|skin(3)|central_nervous_system(1)	11				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		TGGGCTCCAGGACACTCGCAC	0.642			NA											14	95					2.61681e-11	4.01665e-11	0.00245	1	0
PARP3	10039	broad.mit.edu	37	3	51978525	51978525	+	Silent	SNP	G	G	A			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr3:51978525G>A	uc003dby.2	+	4	803	c.432G>A	c.(430-432)GTG>GTA	p.V144V	RRP9_uc003dbw.1_5'Flank|PARP3_uc003dbz.2_Silent_p.V151V	NM_005485	NP_005476	Q9Y6F1	PARP3_HUMAN	poly (ADP-ribose) polymerase family, member 3	144					DNA repair|protein ADP-ribosylation	centriole|nucleus	NAD+ ADP-ribosyltransferase activity|protein binding			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.000541)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)		ACCACTTTGTGTCTCACCCGG	0.517			NA											20	149					0	0	0.010504	0	0
ACTR8	93973	broad.mit.edu	37	3	53904143	53904143	+	Missense_Mutation	SNP	T	T	A			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr3:53904143T>A	uc003dhd.2	-	12	1656	c.1597A>T	c.(1597-1599)AGC>TGC	p.S533C	ACTR8_uc003dhb.2_Missense_Mutation_p.S238C|ACTR8_uc003dhc.2_Missense_Mutation_p.S422C	NM_022899	NP_075050	Q9H981	ARP8_HUMAN	actin-related protein 8	533					cell division|DNA recombination|DNA repair|mitosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	Ino80 complex	protein binding			ovary(1)|central_nervous_system(1)	2				BRCA - Breast invasive adenocarcinoma(193;0.000143)|KIRC - Kidney renal clear cell carcinoma(284;0.00544)|Kidney(284;0.00607)|OV - Ovarian serous cystadenocarcinoma(275;0.111)		AGGATGGAGCTGTACATCTTC	0.348			NA											12	66					0	0	0.00245	0	0
FLJ10213	55096	broad.mit.edu	37	3	73111553	73111553	+	Silent	SNP	C	C	G			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr3:73111553C>G	uc003dpj.2	+	1	744	c.321C>G	c.(319-321)GCC>GCG	p.A107A	PPP4R2_uc003dph.1_Intron|PPP4R2_uc003dpi.1_Intron	NM_018029	NP_060499	Q6P2I7	EBLN2_HUMAN	hypothetical protein LOC55096	107							protein binding				0		Prostate(10;0.0187)|Lung SC(41;0.236)		Epithelial(33;3.9e-05)|BRCA - Breast invasive adenocarcinoma(55;7.72e-05)|LUSC - Lung squamous cell carcinoma(21;0.00156)|Lung(16;0.00487)|KIRC - Kidney renal clear cell carcinoma(39;0.012)|Kidney(39;0.0139)		AAAAAGCAGCCAAGTCTATGC	0.423			NA											4	20					0	0	0.009096	0	0
EPHA3	2042	broad.mit.edu	37	3	89499492	89499492	+	Missense_Mutation	SNP	C	C	A			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr3:89499492C>A	uc003dqy.2	+	15	2887	c.2662C>A	c.(2662-2664)CTG>ATG	p.L888M	EPHA3_uc010hon.1_RNA	NM_005233	NP_005224	P29320	EPHA3_HUMAN	ephrin receptor EphA3 isoform a precursor	888	Cytoplasmic (Potential).					extracellular region|integral to plasma membrane	ATP binding			lung(17)|ovary(7)|large_intestine(4)|central_nervous_system(2)|stomach(1)|skin(1)|pancreas(1)	33	all_cancers(8;0.0406)|Melanoma(1;0.00142)|all_epithelial(1;0.0612)	Lung NSC(201;0.0782)		LUSC - Lung squamous cell carcinoma(29;0.00344)|Lung(72;0.00942)		TCCCGGCAGCCTGAAGATCAT	0.443			NA								TSP Lung(6;0.00050)			10	50					0.000442599	0.000496366	0.006214	1	0
PROS1	5627	broad.mit.edu	37	3	93615497	93615497	+	Missense_Mutation	SNP	C	C	A			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr3:93615497C>A	uc003drb.3	-	9	1229	c.888G>T	c.(886-888)AAG>AAT	p.K296N	PROS1_uc010hoo.2_Missense_Mutation_p.K165N|PROS1_uc003dqz.3_Missense_Mutation_p.K165N	NM_000313	NP_000304	P07225	PROS_HUMAN	protein S, alpha preproprotein	296					leukocyte migration|peptidyl-glutamic acid carboxylation|platelet activation|platelet degranulation|post-translational protein modification|proteolysis	endoplasmic reticulum membrane|extracellular region|Golgi lumen|Golgi membrane|platelet alpha granule lumen	calcium ion binding|endopeptidase inhibitor activity			large_intestine(1)	1					Antihemophilic Factor(DB00025)|Drotrecogin alfa(DB00055)|Menadione(DB00170)	GTAATTCATACTTTGTGTCAA	0.363			NA											33	136					1.07637e-12	1.72707e-12	0.004878	1	0
C3orf30	152405	broad.mit.edu	37	3	118865732	118865732	+	Silent	SNP	C	C	A			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr3:118865732C>A	uc003ecb.1	+	1	736	c.696C>A	c.(694-696)GTC>GTA	p.V232V	IGSF11_uc003eby.2_5'Flank|IGSF11_uc003ebz.2_5'Flank|IGSF11_uc010hqs.2_5'Flank|C3orf30_uc011biw.1_Silent_p.V232V	NM_152539	NP_689752	Q96M34	CC030_HUMAN	hypothetical protein LOC152405	232										ovary(2)	2				GBM - Glioblastoma multiforme(114;0.222)		GGTCATCCGTCCCATCTGACC	0.488			NA											15	85					4.14922e-12	6.54221e-12	0.004007	1	0
C3orf30	152405	broad.mit.edu	37	3	118865747	118865747	+	Missense_Mutation	SNP	T	T	A			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr3:118865747T>A	uc003ecb.1	+	1	751	c.711T>A	c.(709-711)AGT>AGA	p.S237R	IGSF11_uc003eby.2_5'Flank|IGSF11_uc003ebz.2_5'Flank|IGSF11_uc010hqs.2_5'Flank|C3orf30_uc011biw.1_Missense_Mutation_p.S237R	NM_152539	NP_689752	Q96M34	CC030_HUMAN	hypothetical protein LOC152405	237										ovary(2)	2				GBM - Glioblastoma multiforme(114;0.222)		CTGACCAAAGTCCTTCTGTAC	0.458			NA											7	85					0	0	0.008291	0	0
C3orf30	152405	broad.mit.edu	37	3	118865753	118865753	+	Silent	SNP	T	T	C			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr3:118865753T>C	uc003ecb.1	+	1	757	c.717T>C	c.(715-717)TCT>TCC	p.S239S	IGSF11_uc003eby.2_5'Flank|IGSF11_uc003ebz.2_5'Flank|IGSF11_uc010hqs.2_5'Flank|C3orf30_uc011biw.1_Silent_p.S239S	NM_152539	NP_689752	Q96M34	CC030_HUMAN	hypothetical protein LOC152405	239										ovary(2)	2				GBM - Glioblastoma multiforme(114;0.222)		AAAGTCCTTCTGTACAGATTG	0.463			NA											7	84					0	0	0.004482	0	0
C3orf30	152405	broad.mit.edu	37	3	118865771	118865771	+	Silent	SNP	A	A	G			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr3:118865771A>G	uc003ecb.1	+	1	775	c.735A>G	c.(733-735)GGA>GGG	p.G245G	IGSF11_uc003eby.2_5'Flank|IGSF11_uc003ebz.2_5'Flank|IGSF11_uc010hqs.2_5'Flank|C3orf30_uc011biw.1_Silent_p.G245G	NM_152539	NP_689752	Q96M34	CC030_HUMAN	hypothetical protein LOC152405	245										ovary(2)	2				GBM - Glioblastoma multiforme(114;0.222)		TTGACAGTGGATCGTCCGTAC	0.463			NA											5	81					0	0	0.00308	0	0
C3orf30	152405	broad.mit.edu	37	3	118865774	118865774	+	Silent	SNP	G	G	A			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr3:118865774G>A	uc003ecb.1	+	1	778	c.738G>A	c.(736-738)TCG>TCA	p.S246S	IGSF11_uc003eby.2_5'Flank|IGSF11_uc003ebz.2_5'Flank|IGSF11_uc010hqs.2_5'Flank|C3orf30_uc011biw.1_Silent_p.S246S	NM_152539	NP_689752	Q96M34	CC030_HUMAN	hypothetical protein LOC152405	246										ovary(2)	2				GBM - Glioblastoma multiforme(114;0.222)		ACAGTGGATCGTCCGTACCAT	0.468			NA											5	80					0	0	0.00308	0	0
PLA1A	51365	broad.mit.edu	37	3	119325679	119325679	+	Silent	SNP	T	T	C			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr3:119325679T>C	uc003ecu.2	+	2	171	c.132T>C	c.(130-132)TTT>TTC	p.F44F	PLA1A_uc003ecv.2_Silent_p.F44F|PLA1A_uc003ecw.2_RNA|PLA1A_uc011bjc.1_Intron	NM_015900	NP_056984	Q53H76	PLA1A_HUMAN	phospholipase A1 member A precursor	44					lipid catabolic process|phosphatidylserine metabolic process	extracellular region	phospholipase A1 activity			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	3						CCAACCTTTTTGAAGGCACCG	0.512			NA											31	155					0	0	0.012213	0	0
GTF2E1	2960	broad.mit.edu	37	3	120489651	120489651	+	Silent	SNP	A	A	G			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr3:120489651A>G	uc003edz.3	+	3	639	c.525A>G	c.(523-525)ACA>ACG	p.T175T		NM_005513	NP_005504	P29083	T2EA_HUMAN	general transcription factor IIE, polypeptide 1,	175					interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	nucleoplasm	protein binding|zinc ion binding			ovary(1)	1				GBM - Glioblastoma multiforme(114;0.159)		ATGCACGCACACTTTTGGCAA	0.428			NA											30	223					0	0	0.008361	0	0
GOLGB1	2804	broad.mit.edu	37	3	121414623	121414623	+	Missense_Mutation	SNP	C	C	A			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr3:121414623C>A	uc003eei.3	-	13	4858	c.4732G>T	c.(4732-4734)GGT>TGT	p.G1578C	GOLGB1_uc010hrc.2_Missense_Mutation_p.G1583C|GOLGB1_uc003eej.3_Missense_Mutation_p.G1544C|GOLGB1_uc011bjm.1_Missense_Mutation_p.G1464C|GOLGB1_uc010hrd.1_Missense_Mutation_p.G1542C	NM_004487	NP_004478	Q14789	GOGB1_HUMAN	golgi autoantigen, golgin subfamily b,	1578	Cytoplasmic (Potential).|Potential.				Golgi organization	ER-Golgi intermediate compartment|Golgi membrane|Golgi stack|integral to membrane	protein binding			ovary(6)|breast(2)|skin(2)	10				GBM - Glioblastoma multiforme(114;0.0989)		TCAGTAAGACCCTCTAGAGCT	0.383			NA											14	91					9.31168e-06	1.11705e-05	0.001855	1	0
PODXL2	50512	broad.mit.edu	37	3	127379625	127379625	+	Missense_Mutation	SNP	A	A	G			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr3:127379625A>G	uc003ejq.2	+	3	778	c.754A>G	c.(754-756)ACA>GCA	p.T252A		NM_015720	NP_056535	Q9NZ53	PDXL2_HUMAN	podocalyxin-like 2 precursor	252	Extracellular (Potential).				leukocyte tethering or rolling	integral to plasma membrane	glycosaminoglycan binding|protein binding			ovary(1)|central_nervous_system(1)	2						CACCCCAACTACAGTGACTCC	0.627			NA											11	62					0	0	0.008291	0	0
DNAJC13	23317	broad.mit.edu	37	3	132226082	132226082	+	Missense_Mutation	SNP	G	G	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr3:132226082G>T	uc003eor.2	+	43	5065	c.5000G>T	c.(4999-5001)GGT>GTT	p.G1667V		NM_015268	NP_056083	O75165	DJC13_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 13	1667							heat shock protein binding			ovary(1)|breast(1)	2						TTTAAAAAGGGTGATTGTGAC	0.308			NA											9	59					0.00448238	0.00485591	0.004482	1	0
CLSTN2	64084	broad.mit.edu	37	3	140185493	140185493	+	Missense_Mutation	SNP	C	C	A			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr3:140185493C>A	uc003etn.2	+	8	1454	c.1264C>A	c.(1264-1266)CGC>AGC	p.R422S	CLSTN2_uc003etm.2_Missense_Mutation_p.R422S	NM_022131	NP_071414	Q9H4D0	CSTN2_HUMAN	calsyntenin 2 precursor	422	Extracellular (Potential).				homophilic cell adhesion	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|plasma membrane	calcium ion binding			skin(3)|large_intestine(2)|pancreas(1)|central_nervous_system(1)	7						GCACAACTGCCGCCTCGTCTT	0.542	GBM(45;858 913 3709 36904 37282)		NA								HNSCC(16;0.037)			4	72					1.024e-07	1.38197e-07	0.000602	1	0
ZIC4	84107	broad.mit.edu	37	3	147108970	147108970	+	Missense_Mutation	SNP	C	C	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr3:147108970C>T	uc003ewd.1	-	4	1025	c.752G>A	c.(751-753)CGT>CAT	p.R251H	ZIC4_uc003ewc.1_Missense_Mutation_p.R181H|ZIC4_uc011bno.1_Missense_Mutation_p.R301H	NM_032153	NP_115529	Q8N9L1	ZIC4_HUMAN	zinc finger protein of the cerebellum 4	251	C2H2-type 4.					nucleus	DNA binding|zinc ion binding			upper_aerodigestive_tract(1)|central_nervous_system(1)	2						ATGCTTCTTACGGTCGCTGCT	0.617			NA											5	39					0	0	0.001984	0	0
ZIC4	84107	broad.mit.edu	37	3	147113693	147113693	+	Missense_Mutation	SNP	C	C	A			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr3:147113693C>A	uc003ewd.1	-	3	907	c.634G>T	c.(634-636)GGG>TGG	p.G212W	ZIC4_uc003ewc.1_Missense_Mutation_p.G142W|ZIC4_uc011bno.1_Missense_Mutation_p.G262W	NM_032153	NP_115529	Q8N9L1	ZIC4_HUMAN	zinc finger protein of the cerebellum 4	212	C2H2-type 3.					nucleus	DNA binding|zinc ion binding			upper_aerodigestive_tract(1)|central_nervous_system(1)	2						AAGACCTTCCCACACCCCGGG	0.537			NA											29	128					4.87955e-14	8.05253e-14	0.005443	1	0
SLITRK3	22865	broad.mit.edu	37	3	164906009	164906009	+	Silent	SNP	C	C	A			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr3:164906009C>A	uc003fej.3	-	2	3054	c.2610G>T	c.(2608-2610)GTG>GTT	p.V870V	SLITRK3_uc003fek.2_Silent_p.V870V	NM_014926	NP_055741	O94933	SLIK3_HUMAN	slit and trk like 3 protein precursor	870	Cytoplasmic (Potential).					integral to membrane				ovary(6)|skin(3)|pancreas(1)	10						GAGGAAACAGCACCACCCCAC	0.587			NA								HNSCC(40;0.11)			21	120					7.45023e-12	1.16604e-11	0.010504	1	0
KLHL6	89857	broad.mit.edu	37	3	183209738	183209738	+	Missense_Mutation	SNP	C	C	A	rs146413670	byFrequency	TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr3:183209738C>A	uc003flr.2	-	7	1901	c.1843G>T	c.(1843-1845)GTG>TTG	p.V615L	KLHL6_uc003fls.1_RNA|KLHL6_uc003flt.1_3'UTR|KLHL6_uc010hxk.1_RNA	NM_130446	NP_569713	Q8WZ60	KLHL6_HUMAN	kelch-like 6	615										haematopoietic_and_lymphoid_tissue(2)|ovary(1)	3	all_cancers(143;9.2e-12)|Ovarian(172;0.0172)		all cancers(12;1.29e-44)|Epithelial(37;1.24e-38)|LUSC - Lung squamous cell carcinoma(7;2.58e-24)|Lung(8;1.79e-22)|OV - Ovarian serous cystadenocarcinoma(80;2.32e-22)			GCTCCGGGCACGATCCTGCGG	0.667			NA											12	90					5.50884e-06	6.65869e-06	0.013537	1	0
EIF4A2	1974	broad.mit.edu	37	3	186503788	186503788	+	Silent	SNP	T	T	C			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr3:186503788T>C	uc003fqs.2	+	5	504	c.465T>C	c.(463-465)ATT>ATC	p.I155I	EIF4A2_uc003fqt.2_RNA|EIF4A2_uc003fqu.2_Silent_p.I156I|EIF4A2_uc003fqv.2_Silent_p.I60I|EIF4A2_uc003fqw.2_Silent_p.I60I|EIF4A2_uc011bsb.1_Silent_p.I28I|MIR1248_hsa-mir-1248|MI0006383_5'Flank|SNORA81_uc010hyv.1_5'Flank|SNORA63_uc010hyw.1_5'Flank|SNORA4_uc010hyx.1_5'Flank	NM_001967	NP_001958	Q14240	IF4A2_HUMAN	eukaryotic translation initiation factor 4A2	155	Helicase ATP-binding.				interspecies interaction between organisms|nuclear-transcribed mRNA poly(A) tail shortening|regulation of translational initiation	cytosol|eukaryotic translation initiation factor 4F complex	ATP binding|ATP-dependent helicase activity|protein binding|translation initiation factor activity			ovary(2)|breast(2)	4	all_cancers(143;2.68e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;1.07e-20)	GBM - Glioblastoma multiforme(93;0.0704)		CACCACATATTGTTGTTGGTA	0.383			NA	T	BCL6	NHL								6	49					0	0	0.001168	0	0
LRRC15	131578	broad.mit.edu	37	3	194081447	194081447	+	Missense_Mutation	SNP	G	G	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr3:194081447G>T	uc003ftu.2	-	2	412	c.326C>A	c.(325-327)GCC>GAC	p.A109D	LRRC15_uc003ftt.2_Missense_Mutation_p.A115D	NM_130830	NP_570843	Q8TF66	LRC15_HUMAN	leucine rich repeat containing 15 isoform b	109	LRR 3.|Extracellular (Potential).					integral to membrane				ovary(3)	3	all_cancers(143;5.31e-09)|Ovarian(172;0.0634)		OV - Ovarian serous cystadenocarcinoma(49;2.2e-17)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;4.94e-05)		CTTGTTGTTGGCGAGGCTGAG	0.602			NA											7	71					2.0095e-06	2.5099e-06	0.001984	1	0
TACC3	10460	broad.mit.edu	37	4	1733028	1733028	+	Missense_Mutation	SNP	G	G	A			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr4:1733028G>A	uc003gdo.2	+	6	1699	c.1591G>A	c.(1591-1593)GTT>ATT	p.V531I	TACC3_uc010ibz.2_Missense_Mutation_p.V531I|TACC3_uc003gdp.2_Missense_Mutation_p.V171I|TACC3_uc010ica.2_5'UTR	NM_006342	NP_006333	Q9Y6A5	TACC3_HUMAN	transforming, acidic coiled-coil containing	531						centrosome				ovary(1)|central_nervous_system(1)	2		Breast(71;0.212)|all_epithelial(65;0.241)	OV - Ovarian serous cystadenocarcinoma(23;0.00765)|Epithelial(3;0.0126)			CCCCGCTGAGGGTACGTTGCC	0.622	Ovarian(120;482 2294 11894 35824)		NA											16	56					0	0	0.00499	0	0
LYAR	55646	broad.mit.edu	37	4	4275328	4275328	+	Missense_Mutation	SNP	C	C	A	rs79312020	by1000genomes	TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr4:4275328C>A	uc011bvy.1	-	8	1044	c.901G>T	c.(901-903)GAT>TAT	p.D301Y	LYAR_uc011bvx.1_Missense_Mutation_p.D184Y|LYAR_uc003ght.2_Missense_Mutation_p.D301Y	NM_001145725	NP_001139197	Q9NX58	LYAR_HUMAN	Ly1 antibody reactive homolog	301	Lys-rich.					nucleolus	metal ion binding|protein binding				0				UCEC - Uterine corpus endometrioid carcinoma (64;0.168)		GGAGCCTCATCGTCTTCTGGT	0.308			NA											17	84					3.52763e-06	4.34642e-06	0.00499	1	0
CCKAR	886	broad.mit.edu	37	4	26483303	26483303	+	Missense_Mutation	SNP	C	C	A			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr4:26483303C>A	uc003gse.1	-	5	1397	c.1244G>T	c.(1243-1245)AGG>ATG	p.R415M		NM_000730	NP_000721	P32238	CCKAR_HUMAN	cholecystokinin A receptor	415	Cytoplasmic (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|elevation of cytosolic calcium ion concentration|response to nutrient	integral to plasma membrane	cholecystokinin receptor activity			lung(3)|pancreas(1)	4		Breast(46;0.0503)			Ceruletide(DB00403)	GTACGAGAACCTGGACAGAGA	0.552			NA											24	131					3.6726e-16	6.42705e-16	0.003954	1	0
KIT	3815	broad.mit.edu	37	4	55602663	55602663	+	Splice_Site	SNP	G	G	A			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr4:55602663G>A	uc010igr.2	+	18	2572	c.2485_splice	c.e18-1	p.A829_splice	KIT_uc010igs.2_Splice_Site_p.A825_splice	NM_000222	NP_000213	P10721	KIT_HUMAN	v-kit Hardy-Zuckerman 4 feline sarcoma viral						male gonad development|transmembrane receptor protein tyrosine kinase signaling pathway	extracellular space|integral to membrane	ATP binding|protein binding|receptor signaling protein tyrosine kinase activity			soft_tissue(3273)|haematopoietic_and_lymphoid_tissue(1572)|skin(99)|testis(49)|bone(21)|genital_tract(18)|kidney(17)|ovary(16)|salivary_gland(15)|large_intestine(11)|thymus(6)|lung(6)|central_nervous_system(4)|NS(3)|eye(2)|endometrium(2)|breast(1)|stomach(1)|autonomic_ganglia(1)|pancreas(1)	5118	all_cancers(7;0.00453)|all_lung(4;0.000565)|Lung NSC(11;0.00129)|all_epithelial(27;0.0104)|Glioma(25;0.08)|all_neural(26;0.101)		LUSC - Lung squamous cell carcinoma(32;0.000276)|Epithelial(7;0.209)	Colorectal(1;0.0276)|COAD - Colon adenocarcinoma(1;0.171)	Dasatinib(DB01254)|Imatinib(DB00619)|Sorafenib(DB00398)|Sunitinib(DB01268)	TTCTATTACAGGCTCGACTAC	0.403			1	Mis|O		GIST|AML|TGCT|mastocytosis|mucosal melanoma	GIST|epithelioma	Piebald trait		Mast_Cell_disease_Familial_Clustering_of|Piebaldism|Gastrointestinal_Stromal_Tumors_Sporadic_Multiple_Primary|Familial_Gastrointestinal_Stromal_Tumors				18	86					0	0	0.007413	0	0
KIAA1211	57482	broad.mit.edu	37	4	57182249	57182249	+	Missense_Mutation	SNP	G	G	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr4:57182249G>T	uc003hbk.2	+	8	2972	c.2581G>T	c.(2581-2583)GAC>TAC	p.D861Y	KIAA1211_uc010iha.2_Missense_Mutation_p.D854Y|KIAA1211_uc011bzz.1_Missense_Mutation_p.D771Y|KIAA1211_uc003hbm.1_Missense_Mutation_p.D747Y	NM_020722	NP_065773	Q6ZU35	K1211_HUMAN	hypothetical protein LOC57482	861										ovary(1)|skin(1)	2	Glioma(25;0.08)|all_neural(26;0.101)					CTTCAACTGCGACCAACAGGC	0.552			NA											6	44					0.00116845	0.00128549	0.001168	1	0
LPHN3	23284	broad.mit.edu	37	4	62598746	62598746	+	Missense_Mutation	SNP	G	G	C			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr4:62598746G>C	uc010ihh.2	+	5	842	c.669G>C	c.(667-669)GAG>GAC	p.E223D	LPHN3_uc003hcq.3_Missense_Mutation_p.E223D|LPHN3_uc010ihg.1_Missense_Mutation_p.E291D|LPHN3_uc003hcs.1_Missense_Mutation_p.E52D	NM_015236	NP_056051	Q9HAR2	LPHN3_HUMAN	latrophilin 3 precursor	223	Extracellular (Potential).|Olfactomedin-like.				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|sugar binding			lung(15)|ovary(1)|central_nervous_system(1)|pancreas(1)	18						TCAACAAAGAGCGCACCAGGA	0.448			NA											8	42					0	0	0.004482	0	0
TMPRSS11D	9407	broad.mit.edu	37	4	68688116	68688116	+	Missense_Mutation	SNP	G	G	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr4:68688116G>T	uc003hdq.2	-	10	1261	c.1196C>A	c.(1195-1197)CCA>CAA	p.P399Q	LOC550112_uc003hdl.3_Intron|TMPRSS11D_uc003hdp.2_Missense_Mutation_p.P180Q|TMPRSS11D_uc011caj.1_Missense_Mutation_p.P282Q	NM_004262	NP_004253	O60235	TM11D_HUMAN	transmembrane protease, serine 11D	399	Peptidase S1.|Extracellular (Potential).				proteolysis|respiratory gaseous exchange	extracellular region|integral to plasma membrane	serine-type endopeptidase activity			ovary(1)	1						ATACACTCCTGGCTTATCCGG	0.517			NA											20	135					4.96729e-08	6.74662e-08	0.008871	1	0
UGT2B10	7365	broad.mit.edu	37	4	69870707	69870707	+	Missense_Mutation	SNP	A	A	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr4:69870707A>T	uc011cao.1	-	9	1479	c.1343T>A	c.(1342-1344)TTC>TAC	p.F448Y	UGT2B10_uc011can.1_Missense_Mutation_p.F364Y			P36537	UDB10_HUMAN	RecName: Full=UDP-glucuronosyltransferase 2B28;          Short=UDPGT 2B28;          EC=2.4.1.17; Flags: Precursor;	485					lipid metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			skin(3)|ovary(2)	5						GTGGTACTGGAACCAGGTGAG	0.488	Melanoma(133;755 1763 25578 26334 46021)		NA											32	164					0	0	0.013726	0	0
UGT2B4	7363	broad.mit.edu	37	4	70360873	70360873	+	Missense_Mutation	SNP	T	T	A			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr4:70360873T>A	uc003hek.3	-	1	754	c.707A>T	c.(706-708)TAC>TTC	p.Y236F	UGT2B4_uc011cap.1_Missense_Mutation_p.Y100F|UGT2B4_uc003hel.3_Missense_Mutation_p.Y236F	NM_021139	NP_066962	P06133	UD2B4_HUMAN	UDP glucuronosyltransferase 2B4 precursor	236					estrogen catabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			skin(2)	2						AACTTCACTGTAGAACTGATC	0.333			NA											11	54					0	0	0.001855	0	0
ALB	213	broad.mit.edu	37	4	74285336	74285336	+	Nonsense_Mutation	SNP	G	G	T	rs75709682		TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr4:74285336G>T	uc003hgs.3	+	13	1838	c.1765G>T	c.(1765-1767)GAG>TAG	p.E589*	ALB_uc003hgw.3_Nonsense_Mutation_p.E397*|ALB_uc011cbe.1_Nonsense_Mutation_p.E268*|ALB_uc003hgt.3_Nonsense_Mutation_p.E589*|ALB_uc010iii.2_Nonsense_Mutation_p.E474*|ALB_uc003hgu.3_Nonsense_Mutation_p.E439*|ALB_uc003hgv.3_Nonsense_Mutation_p.E268*|ALB_uc011cbf.1_Nonsense_Mutation_p.E479*|ALB_uc010iij.2_RNA|ALB_uc003hgx.3_Nonsense_Mutation_p.E268*	NM_000477	NP_000468	P02768	ALBU_HUMAN	albumin preproprotein	589	Albumin 3.		E -> K (in Osaka-1).		bile acid and bile salt transport|bile acid metabolic process|cellular response to starvation|hemolysis by symbiont of host erythrocytes|lipoprotein metabolic process|maintenance of mitochondrion location|negative regulation of apoptosis|platelet activation|platelet degranulation|sodium-independent organic anion transport|transmembrane transport	extracellular space|platelet alpha granule lumen|protein complex	antioxidant activity|chaperone binding|copper ion binding|DNA binding|drug binding|fatty acid binding|pyridoxal phosphate binding|toxin binding			ovary(3)|skin(3)	6	Breast(15;0.00102)		Epithelial(6;4.8e-05)|OV - Ovarian serous cystadenocarcinoma(6;0.000263)|all cancers(17;0.000472)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)		Acenocoumarol(DB01418)|Acitretin(DB00459)|Alfentanil(DB00802)|Aluminium(DB01370)|Auranofin(DB00995)|Bismuth(DB01402)|Captopril(DB01197)|Carboplatin(DB00958)|Cefalotin(DB00456)|Cefazolin(DB01327)|Cefonicid(DB01328)|Cefoperazone(DB01329)|Chlorpheniramine(DB01114)|Chlorpromazine(DB00477)|Ciprofloxacin(DB00537)|Clonazepam(DB01068)|Cloxacillin(DB01147)|Cytarabine(DB00987)|Dantrolene(DB01219)|Diclofenac(DB00586)|Diflunisal(DB00861)|Digitoxin(DB01396)|Estrone(DB00655)|Ethacrynic acid(DB00903)|Etodolac(DB00749)|Flurbiprofen(DB00712)|Gadobenate Dimeglumine(DB00743)|Gatifloxacin(DB01044)|Gliclazide(DB01120)|Halothane(DB01159)|Human Serum Albumin(DB00062)|Hyaluronidase(DB00070)|Ibuprofen(DB01050)|Insulin-detemir(DB01307)|Insulin-glargine(DB01308)|Iodipamide(DB04711)|Ketoprofen(DB01009)|Levamisole(DB00848)|Levothyroxine(DB00451)|Liothyronine(DB00279)|Mefenamic acid(DB00784)|Mephenytoin(DB00532)|Methotrexate(DB00563)|Nortriptyline(DB00540)|Oxazepam(DB00842)|Paclitaxel(DB01229)|Phenprocoumon(DB00946)|Probenecid(DB01032)|Propofol(DB00818)|Pyridoxine(DB00165)|Salicyclic acid(DB00936)|Saquinavir(DB01232)|Serum albumin(DB00096)|Serum albumin iodonated(DB00064)|Sodium lauryl sulfate(DB00815)|Sucralfate(DB00364)|Sulfamethizole(DB00576)|Sulindac(DB00605)|Suprofen(DB00870)|Testosterone(DB00624)|Xanthophyll(DB00137)	TGACGATAAGGAGACCTGCTT	0.428			NA											13	75					1.3612e-06	1.74114e-06	0.003163	1	0
BMP3	651	broad.mit.edu	37	4	81967361	81967361	+	Silent	SNP	C	C	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr4:81967361C>T	uc003hmg.3	+	2	1106	c.786C>T	c.(784-786)CAC>CAT	p.H262H		NM_001201	NP_001192	P12645	BMP3_HUMAN	bone morphogenetic protein 3 preproprotein	262					cartilage development|cell differentiation|cell-cell signaling|growth|ossification	extracellular space	BMP receptor binding|cytokine activity|growth factor activity			ovary(4)|central_nervous_system(1)	5						TACAGGGACACCGGAATTTTC	0.498			NA											17	97					0	0	0.004007	0	0
AFF1	4299	broad.mit.edu	37	4	88055667	88055667	+	Missense_Mutation	SNP	C	C	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr4:88055667C>T	uc003hqj.3	+	19	3739	c.3332C>T	c.(3331-3333)GCC>GTC	p.A1111V	AFF1_uc011ccz.1_Missense_Mutation_p.A1119V|AFF1_uc003hqk.3_Missense_Mutation_p.A1112V|AFF1_uc011cda.1_Missense_Mutation_p.A750V	NM_005935	NP_005926	P51825	AFF1_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	1111						nucleus	sequence-specific DNA binding transcription factor activity			breast(1)	1		Acute lymphoblastic leukemia(40;0.0935)|all_hematologic(202;0.111)|Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000233)		CCTTCTCCTGCCAGCTCCGTA	0.567			NA											83	374					0	0	0.01441	0	0
ADH1B	125	broad.mit.edu	37	4	100231927	100231927	+	Silent	SNP	C	C	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr4:100231927C>T	uc003hus.3	-	8	1182	c.1098G>A	c.(1096-1098)GGG>GGA	p.G366G	ADH1A_uc011ceg.1_Intron|ADH1B_uc003hut.3_Silent_p.G326G|ADH1B_uc011ceh.1_Silent_p.G211G|ADH1B_uc011cei.1_Silent_p.G326G	NM_000668	NP_000659	P00325	ADH1B_HUMAN	class I alcohol dehydrogenase, beta subunit	366					ethanol oxidation|xenobiotic metabolic process	cytosol	alcohol dehydrogenase activity, zinc-dependent|zinc ion binding			ovary(1)|breast(1)	2				OV - Ovarian serous cystadenocarcinoma(123;1.02e-07)	Fomepizole(DB01213)|NADH(DB00157)	TCTACCTTTTCCCAGAGTGAA	0.338			NA											13	41					0	0	0.013537	0	0
CENPE	1062	broad.mit.edu	37	4	104101595	104101595	+	Missense_Mutation	SNP	T	T	A			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr4:104101595T>A	uc003hxb.1	-	13	1205	c.1115A>T	c.(1114-1116)GAA>GTA	p.E372V	CENPE_uc003hxc.1_Missense_Mutation_p.E372V	NM_001813	NP_001804	Q02224	CENPE_HUMAN	centromere protein E	372	Potential.				blood coagulation|cell division|kinetochore assembly|microtubule-based movement|mitotic chromosome movement towards spindle pole|mitotic metaphase|mitotic metaphase plate congression|mitotic prometaphase|multicellular organismal development|positive regulation of protein kinase activity	condensed chromosome kinetochore|cytosol|microtubule|nucleus|spindle	ATP binding|kinetochore binding|microtubule motor activity			ovary(5)|breast(4)	9				OV - Ovarian serous cystadenocarcinoma(123;2.95e-08)		TTGGTCTTTTTCCATTGCCTG	0.353			NA											5	43					0	0	0.001984	0	0
PITX2	5308	broad.mit.edu	37	4	111539669	111539669	+	Missense_Mutation	SNP	A	A	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr4:111539669A>T	uc003iad.2	-	5	1148	c.566T>A	c.(565-567)CTA>CAA	p.L189Q	PITX2_uc003iac.2_Missense_Mutation_p.L196Q|PITX2_uc003iae.2_Missense_Mutation_p.L143Q|PITX2_uc010iml.2_Missense_Mutation_p.L60Q|PITX2_uc003iaf.2_Missense_Mutation_p.L189Q	NM_153426	NP_700475	Q99697	PITX2_HUMAN	paired-like homeodomain transcription factor 2	189					determination of left/right symmetry|organ morphogenesis	transcription factor complex	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription factor binding				0		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.00222)		CTTGGTGGATAGGGAGGCGGA	0.547			NA											13	50					0	0	0.013537	0	0
ANK2	287	broad.mit.edu	37	4	114158754	114158754	+	Splice_Site	SNP	G	G	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr4:114158754G>T	uc003ibe.3	+	7	770	c.670_splice	c.e7-1	p.M224_splice	ANK2_uc003ibd.3_Splice_Site_p.M203_splice|ANK2_uc003ibf.3_Splice_Site_p.M224_splice|ANK2_uc003ibc.2_Splice_Site_p.M200_splice|ANK2_uc011cgb.1_Splice_Site_p.M239_splice	NM_001148	NP_001139	Q01484	ANK2_HUMAN	ankyrin 2 isoform 1						axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding|protein binding			central_nervous_system(7)|ovary(3)|large_intestine(2)|breast(1)|skin(1)	14		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		CACTGCTTCAGATGATGGTGA	0.363			NA											12	56					0.00185496	0.00203726	0.001855	1	0
TRPC3	7222	broad.mit.edu	37	4	122831533	122831533	+	Missense_Mutation	SNP	C	C	A			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr4:122831533C>A	uc003ieg.2	-	6	1642	c.1568G>T	c.(1567-1569)TGG>TTG	p.W523L	TRPC3_uc010inr.2_Missense_Mutation_p.W395L|TRPC3_uc003ief.2_Missense_Mutation_p.W450L|TRPC3_uc011cgl.1_Missense_Mutation_p.W187L	NM_001130698	NP_001124170	Q13507	TRPC3_HUMAN	transient receptor potential cation channel,	438	Helical; (Potential).				axon guidance|phototransduction|platelet activation	integral to plasma membrane	protein binding|store-operated calcium channel activity			ovary(2)	2						ACATTCAGACCACATCATTCC	0.463			NA											14	61					4.3838e-07	5.7223e-07	0.001855	1	0
KIAA0922	23240	broad.mit.edu	37	4	154525149	154525149	+	Silent	SNP	C	C	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr4:154525149C>T	uc003inm.3	+	25	3034	c.2982C>T	c.(2980-2982)GCC>GCT	p.A994A	KIAA0922_uc010ipp.2_Silent_p.A995A|KIAA0922_uc010ipq.2_Silent_p.A763A	NM_015196	NP_056011	A2VDJ0	T131L_HUMAN	hypothetical protein LOC23240 isoform 2	994	Cytoplasmic (Potential).					integral to membrane				upper_aerodigestive_tract(1)|ovary(1)	2	all_hematologic(180;0.093)	Renal(120;0.118)				CAGCTGCGGCCAGCAGCACCA	0.512			NA											8	70					0	0	0.004482	0	0
FAM198B	51313	broad.mit.edu	37	4	159048600	159048600	+	Missense_Mutation	SNP	T	T	C			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr4:159048600T>C	uc003ipp.3	-	5	1971	c.1519A>G	c.(1519-1521)ATC>GTC	p.I507V	FAM198B_uc003ipq.3_Missense_Mutation_p.I515V|FAM198B_uc003ipr.3_Missense_Mutation_p.I507V	NM_016613	NP_057697	Q6UWH4	F198B_HUMAN	hypothetical protein LOC51313 isoform 2	507	Extracellular (Potential).					Golgi membrane|integral to membrane					0						TGTGCATTGATATAGGTGATA	0.338			NA											35	157					0	0	0.005524	0	0
RAPGEF2	9693	broad.mit.edu	37	4	160252815	160252815	+	Missense_Mutation	SNP	G	G	A			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr4:160252815G>A	uc003iqg.3	+	9	1436	c.1126G>A	c.(1126-1128)GCG>ACG	p.A376T		NM_014247	NP_055062	Q9Y4G8	RPGF2_HUMAN	Rap guanine nucleotide exchange factor 2	376	N-terminal Ras-GEF.				cAMP-mediated signaling|MAPKKK cascade|small GTPase mediated signal transduction	integral to plasma membrane|intracellular	calcium ion binding|diacylglycerol binding|Rap GTPase activator activity|Rap guanyl-nucleotide exchange factor activity|signal transducer activity			lung(2)|upper_aerodigestive_tract(1)|skin(1)	4	all_hematologic(180;0.24)			COAD - Colon adenocarcinoma(41;0.0817)		GTTGAATATCGCGTGTGCTGC	0.403			NA											13	69					0	0	0.003163	0	0
NPY1R	4886	broad.mit.edu	37	4	164247633	164247633	+	Missense_Mutation	SNP	A	A	G			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr4:164247633A>G	uc003iqm.1	-	2	340	c.74T>C	c.(73-75)CTT>CCT	p.L25P	NPY1R_uc011cjj.1_Intron	NM_000909	NP_000900	P25929	NPY1R_HUMAN	neuropeptide Y receptor Y1	25	Extracellular (Potential).				inhibition of adenylate cyclase activity by G-protein signaling pathway|outflow tract morphogenesis	integral to plasma membrane	protein binding			lung(1)|pancreas(1)	2	all_hematologic(180;0.166)	Prostate(90;0.0959)|all_neural(102;0.223)				AAAAGCCAGAAGCTGGGCATT	0.378			NA											7	49					0	0	0.001984	0	0
NPY5R	4889	broad.mit.edu	37	4	164271488	164271488	+	Silent	SNP	C	C	A			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr4:164271488C>A	uc003iqn.2	+	4	245	c.63C>A	c.(61-63)GCC>GCA	p.A21A		NM_006174	NP_006165	Q15761	NPY5R_HUMAN	neuropeptide Y receptor Y5	21	Extracellular (Potential).				cardiac left ventricle morphogenesis|outflow tract morphogenesis	integral to plasma membrane				lung(6)|skin(1)	7	all_hematologic(180;0.166)	Prostate(90;0.109)				ATACTGCTGCCACTCGGAATT	0.383	Melanoma(139;1287 1774 9781 19750 25599)		NA											14	50					7.93312e-07	1.01678e-06	0.00245	1	0
TLL1	7092	broad.mit.edu	37	4	167012334	167012334	+	Missense_Mutation	SNP	G	G	C			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr4:167012334G>C	uc003irh.1	+	19	3144	c.2497G>C	c.(2497-2499)GAA>CAA	p.E833Q	TLL1_uc011cjn.1_Missense_Mutation_p.E856Q|TLL1_uc011cjo.1_Missense_Mutation_p.E657Q	NM_012464	NP_036596	O43897	TLL1_HUMAN	tolloid-like 1 precursor	833	CUB 4.				cell differentiation|proteolysis|skeletal system development	extracellular region	calcium ion binding|metalloendopeptidase activity|zinc ion binding			skin(3)|ovary(2)|breast(1)|central_nervous_system(1)	7	all_hematologic(180;0.221)	Melanoma(52;0.0315)|Prostate(90;0.0405)		GBM - Glioblastoma multiforme(119;0.103)		TGACCACTTAGAAGTATTTGA	0.333			NA											7	40					0	0	0.004482	0	0
GPM6A	2823	broad.mit.edu	37	4	176561298	176561298	+	Silent	SNP	C	C	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr4:176561298C>T	uc003iuf.2	-	6	1470	c.666G>A	c.(664-666)GGG>GGA	p.G222G	GPM6A_uc011ckj.1_Silent_p.G215G|GPM6A_uc003iug.2_Silent_p.G222G|GPM6A_uc003iuh.2_Silent_p.G211G	NM_201591	NP_963885	P51674	GPM6A_HUMAN	glycoprotein M6A isoform 2	222	Helical; (Potential).					cell surface|integral to membrane					0		Breast(14;7.35e-05)|Melanoma(52;0.00909)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;9.21e-19)|Epithelial(43;3.01e-17)|OV - Ovarian serous cystadenocarcinoma(60;2.02e-09)|STAD - Stomach adenocarcinoma(60;0.00083)|GBM - Glioblastoma multiforme(59;0.00168)|LUSC - Lung squamous cell carcinoma(193;0.0388)		TGACTGCTGCCCCAGCTCCAG	0.428			NA											12	59					0	0	0.010729	0	0
ACSL1	2180	broad.mit.edu	37	4	185694265	185694265	+	Silent	SNP	G	G	A			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr4:185694265G>A	uc003iww.2	-	10	1179	c.885C>T	c.(883-885)AGC>AGT	p.S295S	ACSL1_uc011ckm.1_Silent_p.S124S|ACSL1_uc003iwt.1_Silent_p.S295S|ACSL1_uc003iwu.1_Silent_p.S295S|ACSL1_uc011ckn.1_Silent_p.S261S|ACSL1_uc003iwv.1_Silent_p.S295S|ACSL1_uc010ise.1_RNA	NM_001995	NP_001986	P33121	ACSL1_HUMAN	acyl-CoA synthetase long-chain family member 1	295	Cytoplasmic (Potential).				digestion|fatty acid metabolic process|long-chain fatty-acyl-CoA biosynthetic process|regulation of fatty acid oxidation|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane|microsome|mitochondrial outer membrane|peroxisomal membrane	ATP binding|long-chain fatty acid-CoA ligase activity			ovary(2)	2		all_lung(41;7.57e-14)|Lung NSC(41;1.81e-13)|Colorectal(36;0.00172)|Hepatocellular(41;0.00826)|Renal(120;0.00988)|Prostate(90;0.0235)|all_hematologic(60;0.0315)|all_neural(102;0.107)|Medulloblastoma(177;0.146)		all cancers(43;1.33e-28)|Epithelial(43;5.3e-25)|OV - Ovarian serous cystadenocarcinoma(60;4.88e-11)|Colorectal(24;3.59e-06)|STAD - Stomach adenocarcinoma(60;2.72e-05)|GBM - Glioblastoma multiforme(59;2.83e-05)|BRCA - Breast invasive adenocarcinoma(30;7.66e-05)|COAD - Colon adenocarcinoma(29;0.000538)|LUSC - Lung squamous cell carcinoma(40;0.008)|READ - Rectum adenocarcinoma(43;0.0419)	Adenosine monophosphate(DB00131)|Adenosine triphosphate(DB00171)	CTGAACAATCGCTCACTATGT	0.428			NA											11	48					0	0	0.001855	0	0
SORBS2	8470	broad.mit.edu	37	4	186544881	186544881	+	Missense_Mutation	SNP	G	G	A			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr4:186544881G>A	uc003iyl.2	-	13	2548	c.1690C>T	c.(1690-1692)CCC>TCC	p.P564S	SORBS2_uc003iyh.2_Intron|SORBS2_uc011ckw.1_Intron|SORBS2_uc003iyi.2_Intron|SORBS2_uc011ckx.1_Intron|SORBS2_uc003iyk.2_Intron|SORBS2_uc003iym.2_Missense_Mutation_p.P664S|SORBS2_uc003iyn.1_Intron|SORBS2_uc011cku.1_Intron|SORBS2_uc011ckv.1_Missense_Mutation_p.P468S|SORBS2_uc003iyd.2_Intron|SORBS2_uc003iye.2_Intron|SORBS2_uc003iya.2_Intron|SORBS2_uc003iyb.2_Intron|SORBS2_uc003iyc.2_Intron|SORBS2_uc003iyg.2_Missense_Mutation_p.P678S|SORBS2_uc003iyf.2_Intron|SORBS2_uc003iyo.1_Intron	NM_021069	NP_066547	O94875	SRBS2_HUMAN	sorbin and SH3 domain containing 2 isoform 2	564						actin cytoskeleton|nucleus|perinuclear region of cytoplasm|Z disc	cytoskeletal adaptor activity|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			ovary(1)	1		all_cancers(14;4.27e-52)|all_epithelial(14;6.58e-39)|all_lung(41;1.42e-13)|Lung NSC(41;3.73e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.00692)|Hepatocellular(41;0.00826)|Renal(120;0.00994)|Prostate(90;0.0101)|all_hematologic(60;0.0174)|all_neural(102;0.244)		OV - Ovarian serous cystadenocarcinoma(60;1.54e-09)|BRCA - Breast invasive adenocarcinoma(30;0.000232)|GBM - Glioblastoma multiforme(59;0.000385)|STAD - Stomach adenocarcinoma(60;0.00109)|LUSC - Lung squamous cell carcinoma(40;0.0205)		CCCCGAGCGGGGGGGCCGCTT	0.582	Esophageal Squamous(153;41 2433 9491 36028)		NA											11	68					0	0	0.008291	0	0
LRRC14B	389257	broad.mit.edu	37	5	195068	195068	+	Missense_Mutation	SNP	T	T	A			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr5:195068T>A	uc003jal.1	+	2	1173	c.1145T>A	c.(1144-1146)CTG>CAG	p.L382Q		NM_001080478	NP_001073947	A6NHZ5	LR14B_HUMAN	leucine rich repeat containing 14B	382										skin(1)	1						ATGCTGATCCTGGGCCTGAGC	0.662			NA											19	48					0	0	0.007413	0	0
TPPP	11076	broad.mit.edu	37	5	678034	678034	+	Missense_Mutation	SNP	G	G	A			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr5:678034G>A	uc003jbg.3	-	1	860	c.142C>T	c.(142-144)CTC>TTC	p.L48F	TPPP_uc003jbh.3_Missense_Mutation_p.L48F	NM_007030	NP_008961	O94811	TPPP_HUMAN	tubulin polymerization promoting protein	48	Mediates interaction with LIMK1.				microtubule bundle formation|microtubule polymerization|positive regulation of protein polymerization	nucleus|perinuclear region of cytoplasm|soluble fraction	calcium ion binding|microtubule binding				0		Ovarian(839;0.0563)	Epithelial(17;0.000445)|all cancers(22;0.00176)|OV - Ovarian serous cystadenocarcinoma(19;0.00227)|Lung(60;0.0863)	GBM - Glioblastoma multiforme(108;0.0191)		AGGGCACTGAGCTCAGGGGAT	0.697			NA											8	62					0	0	0.004482	0	0
ADAMTS16	170690	broad.mit.edu	37	5	5239793	5239793	+	Splice_Site	SNP	G	G	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr5:5239793G>T	uc003jdl.2	+	16	2417	c.2279_splice	c.e16-1	p.Q760_splice	ADAMTS16_uc003jdk.1_Splice_Site_p.Q760_splice	NM_139056	NP_620687	Q8TE57	ATS16_HUMAN	ADAM metallopeptidase with thrombospondin type 1						proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(3)|lung(2)|large_intestine(1)|breast(1)|pancreas(1)	8						CCTTTATCTAGAGTATTATCA	0.458			NA											32	105					1.03484e-13	1.69023e-13	0.005524	1	0
MARCH6	10299	broad.mit.edu	37	5	10407232	10407232	+	Missense_Mutation	SNP	G	G	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr5:10407232G>T	uc003jet.1	+	17	1654	c.1471G>T	c.(1471-1473)GTC>TTC	p.V491F	MARCH6_uc011cmu.1_Missense_Mutation_p.V443F|MARCH6_uc003jeu.1_Missense_Mutation_p.V189F|MARCH6_uc011cmv.1_Missense_Mutation_p.V386F	NM_005885	NP_005876	O60337	MARH6_HUMAN	membrane-associated ring finger (C3HC4) 6	491	Helical; (Potential).				protein K48-linked ubiquitination	integral to endoplasmic reticulum membrane	ubiquitin conjugating enzyme binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|breast(1)	2						TGGCTCCATTGTCCTCCTGAT	0.408			NA											40	125					1.59932e-28	3.02305e-28	0.007835	1	0
CTNND2	1501	broad.mit.edu	37	5	11117652	11117652	+	Silent	SNP	G	G	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr5:11117652G>T	uc003jfa.1	-	13	2332	c.2187C>A	c.(2185-2187)GCC>GCA	p.A729A	CTNND2_uc010itt.2_Silent_p.A638A|CTNND2_uc011cmy.1_Silent_p.A392A|CTNND2_uc011cmz.1_Silent_p.A296A|CTNND2_uc010itu.1_RNA|CTNND2_uc011cmx.1_Silent_p.A296A	NM_001332	NP_001323	Q9UQB3	CTND2_HUMAN	catenin (cadherin-associated protein), delta 2	729	ARM 6.				multicellular organismal development|neuron cell-cell adhesion|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	adherens junction|cytoplasm|nucleus	protein binding			large_intestine(2)|ovary(2)|skin(2)|pancreas(1)|lung(1)	8						TCCTTCTGCGGGCCTCCTCTC	0.537			NA											20	125					5.03518e-11	7.67323e-11	0.007413	1	0
CTNND2	1501	broad.mit.edu	37	5	11732360	11732360	+	Missense_Mutation	SNP	G	G	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr5:11732360G>T	uc003jfa.1	-	2	207	c.62C>A	c.(61-63)CCT>CAT	p.P21H	CTNND2_uc011cmz.1_5'UTR|CTNND2_uc010itu.1_RNA	NM_001332	NP_001323	Q9UQB3	CTND2_HUMAN	catenin (cadherin-associated protein), delta 2	21					multicellular organismal development|neuron cell-cell adhesion|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	adherens junction|cytoplasm|nucleus	protein binding			large_intestine(2)|ovary(2)|skin(2)|pancreas(1)|lung(1)	8						GGCTGATGAAGGCTGGTCTGG	0.507			NA											31	71					5.45727e-16	9.49803e-16	0.008361	1	0
CDH12	1010	broad.mit.edu	37	5	21752095	21752095	+	Silent	SNP	G	G	A			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr5:21752095G>A	uc010iuc.2	-	12	2594	c.2136C>T	c.(2134-2136)GAC>GAT	p.D712D	CDH12_uc011cno.1_Silent_p.D672D|CDH12_uc003jgk.2_Silent_p.D712D|uc003jgj.2_Intron	NM_004061	NP_004052	P55289	CAD12_HUMAN	cadherin 12, type 2 preproprotein	712	Cytoplasmic (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)	2						AATCCCTTATGTCTGTGTTAT	0.453			NA								HNSCC(59;0.17)			12	67					0	0	0.003163	0	0
TARS	6897	broad.mit.edu	37	5	33462222	33462222	+	Silent	SNP	G	G	A			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr5:33462222G>A	uc003jhy.2	+	16	2044	c.1749G>A	c.(1747-1749)AAG>AAA	p.K583K	TARS_uc011cob.1_Silent_p.K571K|TARS_uc010iup.1_Silent_p.K524K|TARS_uc011coc.1_Silent_p.K604K|TARS_uc003jhz.2_Silent_p.K479K|TARS_uc011cod.1_Silent_p.K462K	NM_152295	NP_689508	P26639	SYTC_HUMAN	threonyl-tRNA synthetase	583					threonyl-tRNA aminoacylation	cytosol	ATP binding|protein homodimerization activity|threonine-tRNA ligase activity			ovary(2)	2					L-Threonine(DB00156)	GTGATGATAAGAAAAGGCCAG	0.353			NA											20	104					0	0	0.010504	0	0
IL7R	3575	broad.mit.edu	37	5	35871178	35871178	+	Missense_Mutation	SNP	G	G	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr5:35871178G>T	uc003jjs.2	+	4	489	c.400G>T	c.(400-402)GAC>TAC	p.D134Y	IL7R_uc011coo.1_Missense_Mutation_p.D134Y|IL7R_uc011cop.1_RNA	NM_002185	NP_002176	P16871	IL7RA_HUMAN	interleukin 7 receptor precursor	134	Extracellular (Potential).|Fibronectin type-III.				immune response|regulation of DNA recombination	extracellular region|integral to membrane	antigen binding|interleukin-7 receptor activity			ovary(3)|breast(1)|skin(1)	5	all_lung(31;0.00015)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Epithelial(62;0.187)|Colorectal(62;0.202)			GGCTCCTTTTGACCTGAGTGT	0.363			NA											14	44					1.49906e-05	1.77162e-05	0.00245	1	0
C5orf42	65250	broad.mit.edu	37	5	37169412	37169412	+	Silent	SNP	G	G	A			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr5:37169412G>A	uc011cpa.1	-	34	6945	c.6714C>T	c.(6712-6714)CCC>CCT	p.P2238P	C5orf42_uc011coy.1_Silent_p.P738P|C5orf42_uc003jks.2_RNA|C5orf42_uc011coz.1_Silent_p.P1313P|C5orf42_uc003jkr.1_Silent_p.P271P	NM_023073	NP_075561	E9PH94	E9PH94_HUMAN	hypothetical protein LOC65250	2238										ovary(4)|breast(2)|skin(1)	7	all_lung(31;0.000616)		COAD - Colon adenocarcinoma(61;0.14)|Epithelial(62;0.177)|Colorectal(62;0.202)			GTAAGAAAAGGGGCTGGAATT	0.443			NA											13	136					0	0	0.00245	0	0
HCN1	348980	broad.mit.edu	37	5	45262209	45262209	+	Silent	SNP	T	T	C			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr5:45262209T>C	uc003jok.2	-	8	2512	c.2487A>G	c.(2485-2487)GCA>GCG	p.A829A		NM_021072	NP_066550	O60741	HCN1_HUMAN	hyperpolarization activated cyclic	829	Cytoplasmic (Potential).					integral to membrane	cAMP binding|sodium channel activity|voltage-gated potassium channel activity			ovary(1)	1						TCCTGCCCCCTGCCTGAAGGC	0.672			NA											13	50					0	0	0.001855	0	0
ACTBL2	345651	broad.mit.edu	37	5	56777820	56777820	+	Silent	SNP	G	G	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr5:56777820G>T	uc003jrm.2	-	1	817	c.715C>A	c.(715-717)CGG>AGG	p.R239R		NM_001017992	NP_001017992	Q562R1	ACTBL_HUMAN	actin, beta-like 2	239						cytoplasm|cytoskeleton	ATP binding			ovary(3)	3		Lung NSC(810;0.000135)|Prostate(74;0.055)|Breast(144;0.0707)|Ovarian(174;0.182)		OV - Ovarian serous cystadenocarcinoma(10;4.24e-37)		TCATAGCTCCGTTCCGGTGAG	0.547			NA											13	60					1.61879e-10	2.41492e-10	0.013537	1	0
MSH3	4437	broad.mit.edu	37	5	80109418	80109418	+	Missense_Mutation	SNP	G	G	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr5:80109418G>T	uc003kgz.2	+	20	2924	c.2671G>T	c.(2671-2673)GTA>TTA	p.V891L		NM_002439	NP_002430	P20585	MSH3_HUMAN	mutS homolog 3	891					maintenance of DNA repeat elements|meiotic mismatch repair|negative regulation of DNA recombination|positive regulation of helicase activity|reciprocal meiotic recombination|somatic recombination of immunoglobulin gene segments	MutSbeta complex|nuclear chromosome	ATP binding|DNA-dependent ATPase activity|double-strand/single-strand DNA junction binding|enzyme binding|loop DNA binding|Y-form DNA binding			lung(2)|ovary(1)|breast(1)	4		Lung NSC(167;0.00479)|all_lung(232;0.00507)|Ovarian(174;0.0261)|Breast(144;0.244)		OV - Ovarian serous cystadenocarcinoma(54;2.38e-45)|Epithelial(54;1.58e-38)|all cancers(79;4.93e-33)		CTCAGAGAGAGTAATGATAAT	0.368	Melanoma(88;1010 1399 13793 26548 36275)		NA						MMR					10	56					2.74318e-10	4.07321e-10	0.006214	1	0
ANKRD32	84250	broad.mit.edu	37	5	94030836	94030836	+	Missense_Mutation	SNP	C	C	A			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr5:94030836C>A	uc003kkr.3	+	21	3076	c.2996C>A	c.(2995-2997)ACC>AAC	p.T999N	ANKRD32_uc003kks.2_Missense_Mutation_p.T363N	NM_032290	NP_115666	Q9BQI6	ANR32_HUMAN	ankyrin repeat domain 32	999										ovary(2)	2		all_cancers(142;1.51e-09)|all_epithelial(76;4.68e-12)|all_lung(232;5.94e-05)|Ovarian(174;0.000953)|Lung NSC(167;0.00105)|Colorectal(57;0.122)|Lung SC(612;0.152)		all cancers(79;3.88e-18)		CATAAAGAAACCACCAGTGTT	0.348			NA											9	46					1.08611e-07	1.45347e-07	0.010729	1	0
MAN2A1	4124	broad.mit.edu	37	5	109026153	109026153	+	Missense_Mutation	SNP	G	G	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr5:109026153G>T	uc003kou.1	+	1	998	c.35G>T	c.(34-36)AGT>ATT	p.S12I	MAN2A1_uc003kot.1_RNA	NM_002372	NP_002363	Q16706	MA2A1_HUMAN	mannosidase, alpha, class 2A, member 1	12	Helical; Signal-anchor for type II membrane protein; (Potential).				mannose metabolic process|post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	alpha-mannosidase activity|carbohydrate binding|mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity|zinc ion binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3		all_cancers(142;8.66e-07)|all_epithelial(76;7.73e-09)|Prostate(80;0.000303)|Lung NSC(167;0.0186)|all_lung(232;0.0241)|Ovarian(225;0.0444)|Colorectal(57;0.0959)|Breast(839;0.244)		OV - Ovarian serous cystadenocarcinoma(64;2.17e-10)|Epithelial(69;1.37e-09)|COAD - Colon adenocarcinoma(37;0.141)		GTGTTCGGCAGTGCGATCTTC	0.582			NA											6	29					2.0095e-06	2.5099e-06	0.001984	1	0
SEMA6A	57556	broad.mit.edu	37	5	115813603	115813603	+	Missense_Mutation	SNP	C	C	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr5:115813603C>T	uc010jck.2	-	15	2297	c.1588G>A	c.(1588-1590)GAC>AAC	p.D530N	SEMA6A_uc003krx.3_Missense_Mutation_p.D530N|SEMA6A_uc003krw.3_Missense_Mutation_p.D62N|SEMA6A_uc010jcj.2_Missense_Mutation_p.D74N	NM_020796	NP_065847	Q9H2E6	SEM6A_HUMAN	sema domain, transmembrane domain (TM), and	530	Extracellular (Potential).				apoptosis|axon guidance|cell surface receptor linked signaling pathway|cytoskeleton organization|organ morphogenesis	axon|integral to membrane|plasma membrane	receptor activity			ovary(2)	2		all_cancers(142;0.00316)|all_epithelial(76;5.71e-05)|Prostate(80;0.00845)|Ovarian(225;0.0796)|Lung NSC(810;0.171)|all_lung(232;0.203)		OV - Ovarian serous cystadenocarcinoma(64;1.59e-08)|Epithelial(69;2e-08)|all cancers(49;5.7e-08)|COAD - Colon adenocarcinoma(49;0.151)		CAATATGGGTCTCTGGAGGCA	0.502			NA											25	141					0	0	0.00632	0	0
FTMT	94033	broad.mit.edu	37	5	121188294	121188294	+	Silent	SNP	G	G	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr5:121188294G>T	uc003kss.2	+	1	645	c.636G>T	c.(634-636)GTG>GTT	p.V212V		NM_177478	NP_803431	Q8N4E7	FTMT_HUMAN	ferritin mitochondrial precursor	212	Ferritin-like diiron.				cellular iron ion homeostasis|iron ion transport|positive regulation of cell proliferation|positive regulation of lyase activity|positive regulation of oxidoreductase activity|positive regulation of transferase activity	mitochondrion	ferric iron binding|ferroxidase activity			ovary(1)	1		all_cancers(142;0.0124)|Prostate(80;0.0322)	KIRC - Kidney renal clear cell carcinoma(527;0.206)	Epithelial(69;0.000171)|OV - Ovarian serous cystadenocarcinoma(64;0.000188)|all cancers(49;0.0027)		GTGACCACGTGCACAACTTAG	0.493			NA											29	175					6.38683e-12	1.00207e-11	0.008361	1	0
SNCAIP	9627	broad.mit.edu	37	5	121786272	121786272	+	Missense_Mutation	SNP	C	C	A			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr5:121786272C>A	uc003ksw.1	+	10	1936	c.1730C>A	c.(1729-1731)CCA>CAA	p.P577Q	SNCAIP_uc011cwl.1_Missense_Mutation_p.P135Q|SNCAIP_uc003ksx.1_Missense_Mutation_p.P624Q|SNCAIP_uc003ksy.1_Missense_Mutation_p.P211Q|SNCAIP_uc003ksz.1_Missense_Mutation_p.P211Q|SNCAIP_uc010jcu.2_Missense_Mutation_p.P173Q|SNCAIP_uc011cwm.1_Missense_Mutation_p.P211Q|SNCAIP_uc003kta.1_Missense_Mutation_p.P209Q|SNCAIP_uc010jcv.1_RNA|SNCAIP_uc010jcw.1_Missense_Mutation_p.P271Q|SNCAIP_uc010jcx.1_Missense_Mutation_p.P517Q|uc003ktb.1_RNA|SNCAIP_uc003ktc.1_Missense_Mutation_p.P93Q	NM_005460	NP_005451	Q9Y6H5	SNCAP_HUMAN	synuclein alpha interacting protein	577					cell death|dopamine metabolic process|regulation of inclusion body assembly|regulation of neurotransmitter secretion	cytoplasm|neuronal cell body|nucleolus|presynaptic membrane	ubiquitin protein ligase binding	p.P577P(1)		ovary(1)|pancreas(1)	2		all_cancers(142;0.00787)|Prostate(80;0.0327)	KIRC - Kidney renal clear cell carcinoma(527;0.206)	OV - Ovarian serous cystadenocarcinoma(64;0.000625)|Epithelial(69;0.00216)|all cancers(49;0.0232)		TGGAAATCTCCAGATGCAGAT	0.483			NA											29	127					5.77227e-19	1.04756e-18	0.008361	1	0
FBN2	2201	broad.mit.edu	37	5	127595228	127595228	+	Silent	SNP	C	C	A			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr5:127595228C>A	uc003kuu.2	-	65	9097	c.8658G>T	c.(8656-8658)CTG>CTT	p.L2886L		NM_001999	NP_001990	P35556	FBN2_HUMAN	fibrillin 2 precursor	2886					bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			ovary(8)|large_intestine(4)|pancreas(1)|kidney(1)|skin(1)	15		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)		TGCTCTCTTCCAGTTTCTTAA	0.507			NA											25	131					1.10923e-09	1.60952e-09	0.00278	1	0
SLC27A6	28965	broad.mit.edu	37	5	128362849	128362849	+	Silent	SNP	C	C	A			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr5:128362849C>A	uc003kuy.2	+	8	1675	c.1279C>A	c.(1279-1281)CGA>AGA	p.R427R	SLC27A6_uc003kuz.2_Silent_p.R427R	NM_014031	NP_054750	Q9Y2P4	S27A6_HUMAN	solute carrier family 27 (fatty acid	427					long-chain fatty acid transport|transmembrane transport|very long-chain fatty acid metabolic process	integral to membrane|sarcolemma	fatty acid transporter activity|long-chain fatty acid-CoA ligase activity|nucleotide binding				0		all_cancers(142;0.0483)|Prostate(80;0.055)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	Epithelial(69;0.171)|OV - Ovarian serous cystadenocarcinoma(64;0.186)		TCTCATTTCTCGAGTGAATGC	0.368			NA											11	63					3.86212e-05	4.47304e-05	0.008291	1	0
TGFBI	7045	broad.mit.edu	37	5	135383018	135383018	+	Missense_Mutation	SNP	G	G	C			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr5:135383018G>C	uc003lbf.3	+	6	841	c.680G>C	c.(679-681)GGG>GCG	p.G227A	TGFBI_uc003lbg.3_5'UTR|TGFBI_uc003lbh.3_Missense_Mutation_p.G53A|TGFBI_uc011cyb.1_Missense_Mutation_p.G53A|TGFBI_uc010jed.2_5'Flank	NM_000358	NP_000349	Q15582	BGH3_HUMAN	transforming growth factor, beta-induced, 68kDa	227	FAS1 1.				angiogenesis|cell adhesion|cell proliferation|negative regulation of cell adhesion|response to stimulus|visual perception	extracellular space|proteinaceous extracellular matrix	integrin binding			breast(3)|ovary(1)	4			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			GCAACCAACGGGGTGGTGCAC	0.537			NA											28	186					0	0	0.007291	0	0
IK	3550	broad.mit.edu	37	5	140038606	140038606	+	Nonsense_Mutation	SNP	G	G	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr5:140038606G>T	uc003lgq.2	+	12	1143	c.1033G>T	c.(1033-1035)GAG>TAG	p.E345*		NM_006083	NP_006074	Q13123	RED_HUMAN	RED protein	345	2.|17 X 2 AA tandem repeats of R-[ED].				cell-cell signaling|immune response	extracellular space|nucleus|soluble fraction				large_intestine(1)	1		all_hematologic(541;4.8e-07)|all_lung(500;0.000434)|Lung NSC(810;0.00161)|Breast(839;0.128)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			tcgggaacgggagcgtgatcg	0.149			NA											12	58					1.61879e-10	2.41492e-10	0.013537	1	0
PCDHA2	56146	broad.mit.edu	37	5	140176297	140176297	+	Nonsense_Mutation	SNP	G	G	A			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr5:140176297G>A	uc003lhd.2	+	1	1854	c.1748G>A	c.(1747-1749)TGG>TAG	p.W583*	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhc.1_Nonsense_Mutation_p.W583*|PCDHA2_uc011czy.1_Nonsense_Mutation_p.W583*	NM_018905	NP_061728	Q9Y5H9	PCDA2_HUMAN	protocadherin alpha 2 isoform 1 precursor	583	Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(4)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTGGTGCCGTGGTCGGTGGGT	0.662			NA											15	120					0	0	0.00245	0	0
PCDHA5	56143	broad.mit.edu	37	5	140202930	140202930	+	Missense_Mutation	SNP	C	C	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr5:140202930C>T	uc003lhl.2	+	1	1570	c.1570C>T	c.(1570-1572)CAC>TAC	p.H524Y	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Missense_Mutation_p.H524Y|PCDHA5_uc003lhj.1_Missense_Mutation_p.H524Y	NM_018908	NP_061731	Q9Y5H7	PCDA5_HUMAN	protocadherin alpha 5 isoform 1 precursor	524	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(1)|breast(1)|skin(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCCGCTGGACCACGAGGAAGT	0.692			NA											30	150					0	0	0.009535	0	0
PCDHB2	56133	broad.mit.edu	37	5	140474443	140474443	+	Silent	SNP	G	G	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr5:140474443G>T	uc003lil.2	+	1	207	c.69G>T	c.(67-69)CTG>CTT	p.L23L	PCDHB2_uc003lim.1_Intron	NM_018936	NP_061759	Q9Y5E7	PCDB2_HUMAN	protocadherin beta 2 precursor	23					calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			ovary(3)|upper_aerodigestive_tract(2)|pancreas(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TTGTTTTGCTGGGCATAGCTC	0.537			NA											9	72					1.76689e-08	2.45209e-08	0.006214	1	0
PCDHB3	56132	broad.mit.edu	37	5	140481091	140481091	+	Missense_Mutation	SNP	A	A	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr5:140481091A>T	uc003lio.2	+	1	858	c.858A>T	c.(856-858)GAA>GAT	p.E286D	uc003lin.2_Intron	NM_018937	NP_061760	Q9Y5E6	PCDB3_HUMAN	protocadherin beta 3 precursor	286	Extracellular (Potential).|Cadherin 3.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			ovary(1)|pancreas(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			ATGCTTCTGAAGAAATTCGCA	0.363			NA											14	73					0	0	0.00245	0	0
PCDHB4	56131	broad.mit.edu	37	5	140503916	140503916	+	Missense_Mutation	SNP	G	G	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr5:140503916G>T	uc003lip.1	+	1	2336	c.2336G>T	c.(2335-2337)GGG>GTG	p.G779V		NM_018938	NP_061761	Q9Y5E5	PCDB4_HUMAN	protocadherin beta 4 precursor	779	Cytoplasmic (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	cytoplasm|integral to plasma membrane|intermediate filament cytoskeleton	calcium ion binding			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CAGGACACCGGGAGGGAAGTT	0.448			NA											18	94					5.03518e-11	7.67323e-11	0.007413	1	0
PCDHB6	56130	broad.mit.edu	37	5	140531365	140531365	+	Silent	SNP	C	C	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr5:140531365C>T	uc003lir.2	+	1	1527	c.1527C>T	c.(1525-1527)GGC>GGT	p.G509G	PCDHB6_uc011dah.1_Silent_p.G373G	NM_018939	NP_061762	Q9Y5E3	PCDB6_HUMAN	protocadherin beta 6 precursor	509	Cadherin 5.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			skin(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CGGACAACGGCCACCTGTTTG	0.672			NA											36	198					0	0	0.005524	0	0
PCDHB8	56128	broad.mit.edu	37	5	140558989	140558989	+	Silent	SNP	C	C	A			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr5:140558989C>A	uc011dai.1	+	1	1560	c.1374C>A	c.(1372-1374)ACC>ACA	p.T458T	PCDHB16_uc003liv.2_5'Flank|PCDHB16_uc010jfw.1_5'Flank	NM_019120	NP_061993	Q9UN66	PCDB8_HUMAN	protocadherin beta 8 precursor	458	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			skin(4)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CCTCCTACACCCTGTTCGTCC	0.612			NA											31	227					3.76114e-14	6.25547e-14	0.004289	1	0
PCDHB10	56126	broad.mit.edu	37	5	140574002	140574002	+	Missense_Mutation	SNP	C	C	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr5:140574002C>T	uc003lix.2	+	1	2051	c.1877C>T	c.(1876-1878)ACC>ATC	p.T626I		NM_018930	NP_061753	Q9UN67	PCDBA_HUMAN	protocadherin beta 10 precursor	626	Cadherin 6.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			ovary(1)|skin(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GAGGTGCGCACCGCCAGGCTG	0.692			NA											15	72					0	0	0.00333	0	0
PCDHB10	56126	broad.mit.edu	37	5	140574378	140574378	+	Nonsense_Mutation	SNP	C	C	A			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr5:140574378C>A	uc003lix.2	+	1	2427	c.2253C>A	c.(2251-2253)TAC>TAA	p.Y751*		NM_018930	NP_061753	Q9UN67	PCDBA_HUMAN	protocadherin beta 10 precursor	751	Cytoplasmic (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			ovary(1)|skin(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CCCAGAGCTACCAGTATGAGG	0.622			NA											24	183					9.95505e-16	1.71853e-15	0.014323	1	0
PCDHB14	56122	broad.mit.edu	37	5	140603152	140603152	+	Silent	SNP	G	G	A			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr5:140603152G>A	uc003ljb.2	+	1	75	c.75G>A	c.(73-75)CGG>CGA	p.R25R	PCDHB14_uc011dal.1_Intron	NM_018934	NP_061757	Q9Y5E9	PCDBE_HUMAN	protocadherin beta 14 precursor	25					calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GATTGTCTCGGGCAGGTACTG	0.498	Ovarian(141;50 1831 27899 33809 37648)		NA											11	42					0	0	0.008291	0	0
PCDHGA3	56112	broad.mit.edu	37	5	140723667	140723667	+	Silent	SNP	C	C	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr5:140723667C>T	uc003ljm.1	+	1	67	c.67C>T	c.(67-69)CTG>TTG	p.L23L	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc010jfx.1_5'UTR|PCDHGA3_uc011dap.1_Silent_p.L23L	NM_018916	NP_061739	Q9Y5H0	PCDG3_HUMAN	protocadherin gamma subfamily A, 3 isoform 1	23					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCTGGGGACGCTGTGCGAAAC	0.557			NA									OREG0016855	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	40	220					0	0	0.009718	0	0
PCDHGA3	56112	broad.mit.edu	37	5	140725254	140725254	+	Missense_Mutation	SNP	G	G	T	rs2879227		TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr5:140725254G>T	uc003ljm.1	+	1	1654	c.1654G>T	c.(1654-1656)GTG>TTG	p.V552L	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc010jfx.1_Missense_Mutation_p.V312L|PCDHGA3_uc011dap.1_Missense_Mutation_p.V552L	NM_018916	NP_061739	Q9Y5H0	PCDG3_HUMAN	protocadherin gamma subfamily A, 3 isoform 1	552	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GAACCTGTTCGTGCTGGACCA	0.617			NA											55	223					1.10885e-35	2.12113e-35	0.01441	1	0
PCDHGA3	56112	broad.mit.edu	37	5	140725835	140725835	+	Silent	SNP	G	G	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr5:140725835G>T	uc003ljm.1	+	1	2235	c.2235G>T	c.(2233-2235)GGG>GGT	p.G745G	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc010jfx.1_Silent_p.G505G|PCDHGA3_uc011dap.1_Silent_p.G745G	NM_018916	NP_061739	Q9Y5H0	PCDG3_HUMAN	protocadherin gamma subfamily A, 3 isoform 1	745	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCGCGGACGGGGTTCGGGCTT	0.667			NA											16	127					3.41278e-10	5.05568e-10	0.00499	1	0
PCDHGB1	56104	broad.mit.edu	37	5	140732157	140732157	+	Missense_Mutation	SNP	T	T	A			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr5:140732157T>A	uc003ljo.1	+	1	2330	c.2330T>A	c.(2329-2331)CTG>CAG	p.L777Q	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGA4_uc003ljq.1_5'Flank|PCDHGB1_uc011daq.1_Missense_Mutation_p.L777Q|PCDHGA4_uc003ljp.1_5'Flank	NM_018922	NP_061745	Q9Y5G3	PCDGD_HUMAN	protocadherin gamma subfamily B, 1 isoform 1	777	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CAGGATCTGCTGTGTGATGAT	0.433			NA											8	32					0	0	0.00308	0	0
PCDHGA11	56105	broad.mit.edu	37	5	140801052	140801052	+	Missense_Mutation	SNP	C	C	G			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr5:140801052C>G	uc003lkq.1	+	1	516	c.258C>G	c.(256-258)ATC>ATG	p.I86M	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc003lkh.1_Intron|PCDHGB6_uc003lkj.1_Intron|PCDHGA10_uc003lkl.1_Intron|PCDHGB7_uc003lkn.1_Intron|PCDHGA11_uc003lko.1_Missense_Mutation_p.I86M|PCDHGA11_uc003lkp.1_Missense_Mutation_p.I86M	NM_018914	NP_061737	Q9Y5H2	PCDGB_HUMAN	protocadherin gamma subfamily A, 11 isoform 1	86	Extracellular (Potential).|Cadherin 1.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCAGCTTGATCACGGCAGGCA	0.572			NA											18	74					0	0	0.010504	0	0
PCDH1	5097	broad.mit.edu	37	5	141243248	141243248	+	Missense_Mutation	SNP	T	T	C			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr5:141243248T>C	uc003llq.2	-	3	2765	c.2648A>G	c.(2647-2649)AAA>AGA	p.K883R	PCDH1_uc003llp.2_Missense_Mutation_p.K883R|PCDH1_uc011dbf.1_Missense_Mutation_p.K861R	NM_002587	NP_002578	Q08174	PCDH1_HUMAN	protocadherin 1 isoform 1 precursor	883	Cytoplasmic (Potential).				cell-cell signaling|homophilic cell adhesion|nervous system development	cell-cell junction|integral to plasma membrane	calcium ion binding			ovary(5)	5		Lung NSC(810;0.027)|all_lung(500;0.0321)|all_hematologic(541;0.0433)|Prostate(461;0.0453)|Breast(839;0.128)|Lung SC(612;0.238)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)	GBM - Glioblastoma multiforme(465;1.06e-05)		GTAACCACTTTTGGCCTCCCG	0.582	Ovarian(132;1609 1739 4190 14731 45037)		NA											58	244					0	0	0.01441	0	0
ADRB2	154	broad.mit.edu	37	5	148206928	148206928	+	Missense_Mutation	SNP	C	C	A	rs147102529		TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr5:148206928C>A	uc003lpr.1	+	1	773	c.534C>A	c.(532-534)CAC>CAA	p.H178Q	SH3TC2_uc003lpp.1_Intron	NM_000024	NP_000015	P07550	ADRB2_HUMAN	adrenergic, beta-2-, receptor, surface	178	Extracellular.				activation of transmembrane receptor protein tyrosine kinase activity|desensitization of G-protein coupled receptor protein signaling pathway by arrestin|endosome to lysosome transport|positive regulation of MAPKKK cascade|receptor-mediated endocytosis	endosome|integral to plasma membrane|lysosome|receptor complex	beta2-adrenergic receptor activity|norepinephrine binding|potassium channel regulator activity|protein homodimerization activity			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)		Alprenolol(DB00866)|Arformoterol(DB01274)|Bambuterol(DB01408)|Bisoprolol(DB00612)|Bitolterol(DB00901)|Bretylium(DB01158)|Carteolol(DB00521)|Carvedilol(DB01136)|Clenbuterol(DB01407)|Desipramine(DB01151)|Epinephrine(DB00668)|Fenoterol(DB01288)|Formoterol(DB00983)|Isoproterenol(DB01064)|Labetalol(DB00598)|Levobunolol(DB01210)|Metipranolol(DB01214)|Nadolol(DB01203)|Norepinephrine(DB00368)|Orciprenaline(DB00816)|Oxprenolol(DB01580)|Penbutolol(DB01359)|Pindolol(DB00960)|Pirbuterol(DB01291)|Procaterol(DB01366)|Propranolol(DB00571)|Pseudoephedrine(DB00852)|Ritodrine(DB00867)|Salbutamol(DB01001)|Salmeterol(DB00938)|Terbutaline(DB00871)|Timolol(DB00373)	GGGCCACCCACCAGGAAGCCA	0.532			NA											24	176					5.45024e-15	9.20903e-15	0.00333	1	0
SH3TC2	79628	broad.mit.edu	37	5	148420208	148420208	+	Missense_Mutation	SNP	C	C	A			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr5:148420208C>A	uc003lpu.2	-	7	916	c.764G>T	c.(763-765)GGC>GTC	p.G255V	SH3TC2_uc003lpp.1_RNA|SH3TC2_uc003lps.2_RNA|SH3TC2_uc003lpt.2_5'UTR|SH3TC2_uc010jgx.2_Missense_Mutation_p.G248V|SH3TC2_uc003lpv.1_5'UTR|SH3TC2_uc011dbz.1_Missense_Mutation_p.G140V	NM_024577	NP_078853	Q8TF17	S3TC2_HUMAN	SH3 domain and tetratricopeptide repeats 2	255							binding			ovary(2)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCTGGAAAGGCCACAGCTTCC	0.418			NA											16	57					1.67942e-08	2.35118e-08	0.006122	1	0
FAT2	2196	broad.mit.edu	37	5	150945590	150945590	+	Missense_Mutation	SNP	G	G	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr5:150945590G>T	uc003lue.3	-	1	2916	c.2903C>A	c.(2902-2904)GCC>GAC	p.A968D	GM2A_uc011dcs.1_Intron|FAT2_uc010jhx.1_Missense_Mutation_p.A968D	NM_001447	NP_001438	Q9NYQ8	FAT2_HUMAN	FAT tumor suppressor 2 precursor	968	Extracellular (Potential).|Cadherin 8.				epithelial cell migration|homophilic cell adhesion	cell-cell adherens junction|integral to membrane|nucleus	calcium ion binding			ovary(4)|upper_aerodigestive_tract(1)|skin(1)	6		Medulloblastoma(196;0.0912)|all_hematologic(541;0.104)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			GGTCCCATGGGCGCCATCCAT	0.607			NA											10	59					0.000673444	0.000748663	0.008291	1	0
FAT2	2196	broad.mit.edu	37	5	150946786	150946786	+	Silent	SNP	A	A	G			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr5:150946786A>G	uc003lue.3	-	1	1720	c.1707T>C	c.(1705-1707)TGT>TGC	p.C569C	GM2A_uc011dcs.1_Intron|FAT2_uc010jhx.1_Silent_p.C569C	NM_001447	NP_001438	Q9NYQ8	FAT2_HUMAN	FAT tumor suppressor 2 precursor	569	Extracellular (Potential).|Cadherin 5.				epithelial cell migration|homophilic cell adhesion	cell-cell adherens junction|integral to membrane|nucleus	calcium ion binding			ovary(4)|upper_aerodigestive_tract(1)|skin(1)	6		Medulloblastoma(196;0.0912)|all_hematologic(541;0.104)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			TAGACCCTGTACAGTTGACTT	0.458			NA											10	93					0	0	0.006214	0	0
MRPL22	29093	broad.mit.edu	37	5	154320679	154320679	+	Silent	SNP	G	G	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr5:154320679G>T	uc003lvy.3	+	1	47	c.9G>T	c.(7-9)GCG>GCT	p.A3A	GEMIN5_uc003lvx.3_5'Flank|GEMIN5_uc011ddk.1_5'Flank|MRPL22_uc003lvz.3_5'UTR	NM_014180	NP_054899	Q9NWU5	RM22_HUMAN	mitochondrial ribosomal protein L22 isoform a	3					translation	large ribosomal subunit|mitochondrion	structural constituent of ribosome				0	Renal(175;0.00488)	Medulloblastoma(196;0.0354)|all_neural(177;0.147)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)			AGATGGCGGCGGCAGTACTGG	0.562			NA											22	115					3.5997e-14	6.00264e-14	0.014323	1	0
THG1L	54974	broad.mit.edu	37	5	157158616	157158616	+	Silent	SNP	G	G	A			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr5:157158616G>A	uc003lxd.2	+	1	294	c.168G>A	c.(166-168)CGG>CGA	p.R56R	THG1L_uc011ddu.1_5'UTR	NM_017872	NP_060342	Q9NWX6	THG1_HUMAN	interphase cytoplasmic foci protein 45	56					protein homotetramerization|tRNA modification	mitochondrion	GTP binding|metal ion binding|tRNA guanylyltransferase activity				0	Renal(175;0.00488)	Medulloblastoma(196;0.0523)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			TGGTAGTGCGGCTGGACGGCC	0.622			NA											29	165					0	0	0.008361	0	0
GABRA6	2559	broad.mit.edu	37	5	161128728	161128728	+	Nonsense_Mutation	SNP	G	G	A			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr5:161128728G>A	uc003lyu.2	+	9	1649	c.1311G>A	c.(1309-1311)TGG>TGA	p.W437*	GABRA6_uc003lyv.2_Nonsense_Mutation_p.W208*	NM_000811	NP_000802	Q16445	GBRA6_HUMAN	gamma-aminobutyric acid A receptor, alpha 6	437	Helical; (Probable).				gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity			ovary(7)|skin(3)|large_intestine(1)|central_nervous_system(1)	12	Renal(175;0.00259)	Medulloblastoma(196;0.0208)|all_neural(177;0.0672)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)		Alprazolam(DB00404)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	TTGTGTACTGGGTAGTTTATC	0.443			NA								TCGA Ovarian(5;0.080)			12	55					0	0	0.013537	0	0
GABRG2	2566	broad.mit.edu	37	5	161580240	161580240	+	Missense_Mutation	SNP	T	T	A			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr5:161580240T>A	uc003lyz.3	+	9	1628	c.1270T>A	c.(1270-1272)TGT>AGT	p.C424S	GABRG2_uc010jjc.2_Missense_Mutation_p.C472S|GABRG2_uc003lyy.3_Missense_Mutation_p.C432S|GABRG2_uc011dej.1_Missense_Mutation_p.C329S	NM_000816	NP_000807	P18507	GBRG2_HUMAN	gamma-aminobutyric acid A receptor, gamma 2	424	Cytoplasmic (Probable).				gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity|protein binding			ovary(4)|skin(1)	5	Renal(175;0.000319)	Medulloblastoma(196;0.0208)|all_neural(177;0.0672)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0734)|OV - Ovarian serous cystadenocarcinoma(192;0.135)|Epithelial(171;0.136)		TTTTGAAGATTGTCGAACAGG	0.463			NA											19	121					0	0	0.006122	0	0
MGAT4B	11282	broad.mit.edu	37	5	179227513	179227513	+	Missense_Mutation	SNP	C	C	G			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr5:179227513C>G	uc003mks.2	-	6	1059	c.690G>C	c.(688-690)GAG>GAC	p.E230D	MGAT4B_uc003mkp.2_Missense_Mutation_p.E85D|MGAT4B_uc003mkq.2_Missense_Mutation_p.E85D|MGAT4B_uc003mkr.2_Missense_Mutation_p.E245D|MIR1229_hsa-mir-1229|MI0006319_5'Flank	NM_014275	NP_055090	Q9UQ53	MGT4B_HUMAN	alpha-1,3-mannosyl-glycoprotein	230	Lumenal (Potential).				N-glycan processing|post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity|metal ion binding				0	all_cancers(89;0.000201)|all_epithelial(37;6.84e-05)|Renal(175;0.000159)|Lung NSC(126;0.00136)|all_lung(126;0.00243)	all_cancers(40;0.0525)|Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CCCCAAAGGACTCTCGGAGGC	0.602	GBM(13;414 434 4098 22176 23230)		NA											4	17					0	0	0.009096	0	0
MGAT4B	11282	broad.mit.edu	37	5	179227594	179227594	+	Missense_Mutation	SNP	G	G	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr5:179227594G>T	uc003mks.2	-	6	978	c.609C>A	c.(607-609)TTC>TTA	p.F203L	MGAT4B_uc003mkp.2_Missense_Mutation_p.F58L|MGAT4B_uc003mkq.2_Missense_Mutation_p.F58L|MGAT4B_uc003mkr.2_Missense_Mutation_p.F218L|MIR1229_hsa-mir-1229|MI0006319_5'Flank	NM_014275	NP_055090	Q9UQ53	MGT4B_HUMAN	alpha-1,3-mannosyl-glycoprotein	203	Lumenal (Potential).				N-glycan processing|post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity|metal ion binding				0	all_cancers(89;0.000201)|all_epithelial(37;6.84e-05)|Renal(175;0.000159)|Lung NSC(126;0.00136)|all_lung(126;0.00243)	all_cancers(40;0.0525)|Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			TCTCCGTGGGGAACCTGGGGG	0.647	GBM(13;414 434 4098 22176 23230)		NA											4	29					1.23904e-05	1.47252e-05	0.000602	1	0
CDYL	9425	broad.mit.edu	37	6	4892523	4892523	+	Missense_Mutation	SNP	G	G	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr6:4892523G>T	uc003mwi.2	+	4	894	c.763G>T	c.(763-765)GGG>TGG	p.G255W	CDYL_uc003mwj.2_Missense_Mutation_p.G201W|CDYL_uc003mwk.2_Intron|CDYL_uc011dhx.1_Missense_Mutation_p.G69W|CDYL_uc011dhy.1_Missense_Mutation_p.G69W	NM_001143971	NP_001137443	Q9Y232	CDYL1_HUMAN	chromodomain protein, Y chromosome-like isoform	255					regulation of transcription, DNA-dependent|spermatogenesis|transcription, DNA-dependent	nucleus	histone acetyltransferase activity				0	Ovarian(93;0.11)	all_hematologic(90;0.0901)|Lung NSC(90;0.244)		OV - Ovarian serous cystadenocarcinoma(45;0.182)		GGCCAGGATGGGGAGCAGGCC	0.642			NA											13	56					5.50884e-06	6.65869e-06	0.013537	1	0
HLA-H	3136	broad.mit.edu	37	6	29855800	29855800	+	Missense_Mutation	SNP	T	T	A			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr6:29855800T>A	uc010jro.2	+	2	89	c.37T>A	c.(37-39)TCC>ACC	p.S13T	HLA-G_uc011dmb.1_Intron|HLA-H_uc003nod.2_RNA					SubName: Full=cDNA FLJ52667, highly similar to HLA class I histocompatibility antigen, alpha chain H;												0						CCGCTTCATCTCCGTCGGCTA	0.692			NA											3	24					0	0	0.001984	0	0
USP49	25862	broad.mit.edu	37	6	41773944	41773944	+	Missense_Mutation	SNP	T	T	A			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr6:41773944T>A	uc003ori.2	-	4	1000	c.778A>T	c.(778-780)AAC>TAC	p.N260Y		NM_018561	NP_061031	Q70CQ1	UBP49_HUMAN	ubiquitin thioesterase 49	260					ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2	Ovarian(28;0.0919)|Colorectal(47;0.121)		STAD - Stomach adenocarcinoma(11;0.000204)|Epithelial(12;0.000309)|Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)			TAGCAGGTGTTGCCCAGGTTG	0.582			NA											7	78					0	0	0.001984	0	0
PRPH2	5961	broad.mit.edu	37	6	42672193	42672193	+	Nonsense_Mutation	SNP	C	C	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr6:42672193C>T	uc003osk.2	-	2	1024	c.738G>A	c.(736-738)TGG>TGA	p.W246*		NM_000322	NP_000313	P23942	PRPH2_HUMAN	peripherin 2	246	Lumenal (Potential).				cell adhesion|visual perception	integral to membrane				ovary(4)|central_nervous_system(1)	5	Colorectal(47;0.196)		Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)|all cancers(41;0.00178)|KIRC - Kidney renal clear cell carcinoma(15;0.02)|Kidney(15;0.0388)|OV - Ovarian serous cystadenocarcinoma(102;0.0904)			AGCCACGCACCCACAGGTTGA	0.587			NA											4	41					0	0	0.009096	0	0
CUL7	9820	broad.mit.edu	37	6	43020329	43020329	+	Silent	SNP	C	C	A			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr6:43020329C>A	uc003otq.2	-	2	501	c.198G>T	c.(196-198)CTG>CTT	p.L66L	CUL7_uc011dvb.1_Silent_p.L118L|CUL7_uc010jyh.2_Missense_Mutation_p.C35F|KLC4_uc003otr.1_Intron	NM_014780	NP_055595	Q14999	CUL7_HUMAN	cullin 7	66					interspecies interaction between organisms|ubiquitin-dependent protein catabolic process|vasculogenesis	anaphase-promoting complex|mitochondrion	ubiquitin protein ligase binding			ovary(3)|kidney(1)	4			all cancers(41;0.00231)|Colorectal(64;0.00237)|COAD - Colon adenocarcinoma(64;0.00473)|OV - Ovarian serous cystadenocarcinoma(102;0.0442)|KIRC - Kidney renal clear cell carcinoma(15;0.133)|Kidney(15;0.188)			ACATCCACAGCAGGATGTGCT	0.617			NA											11	107					0.000978159	0.00108552	0.010729	1	0
SPATS1	221409	broad.mit.edu	37	6	44310868	44310868	+	Silent	SNP	G	G	A			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr6:44310868G>A	uc003oxk.2	+	1	383	c.36G>A	c.(34-36)CGG>CGA	p.R12R	SPATS1_uc003oxg.2_Intron|SPATS1_uc010jzb.2_5'UTR	NM_145026	NP_659463	Q496A3	SPAS1_HUMAN	spermatogenesis associated, serine-rich 1	12										skin(1)	1	all_lung(25;0.00469)|Ovarian(13;0.0273)|all_hematologic(164;0.208)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)			ACAGTCCACGGGGCTGCCGTC	0.517			NA											9	44					0	0	0.006214	0	0
RHAG	6005	broad.mit.edu	37	6	49580220	49580220	+	Nonsense_Mutation	SNP	C	C	A			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr6:49580220C>A	uc003ozk.3	-	6	897	c.835G>T	c.(835-837)GGA>TGA	p.G279*	RHAG_uc010jzl.2_Nonsense_Mutation_p.G279*|RHAG_uc010jzm.2_Nonsense_Mutation_p.G279*	NM_000324	NP_000315	Q02094	RHAG_HUMAN	Rh-associated glycoprotein	279	Helical; (Potential).				carbon dioxide transport|cellular ion homeostasis	integral to plasma membrane	ammonia transmembrane transporter activity|ammonium transmembrane transporter activity|ankyrin binding			breast(1)|skin(1)	2	Lung NSC(77;0.0255)					GCAACTCCTCCAGCAAGGGTG	0.468	Ovarian(176;476 2003 7720 43408 44749)		NA											10	37					1.08611e-07	1.45347e-07	0.010729	1	0
GCLC	2729	broad.mit.edu	37	6	53385617	53385617	+	Silent	SNP	T	T	C			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr6:53385617T>C	uc003pbw.1	-	3	793	c.405A>G	c.(403-405)TTA>TTG	p.L135L	GCLC_uc003pbx.2_Silent_p.L135L	NM_001498	NP_001489	P48506	GSH1_HUMAN	glutamate-cysteine ligase, catalytic subunit	135					anti-apoptosis|cell redox homeostasis|cysteine metabolic process|glutamate metabolic process|glutathione biosynthetic process|negative regulation of transcription, DNA-dependent|regulation of blood vessel size|response to heat|response to hormone stimulus|response to oxidative stress|xenobiotic metabolic process	cytosol	ADP binding|ATP binding|coenzyme binding|glutamate binding|glutamate-cysteine ligase activity|magnesium ion binding			ovary(1)|central_nervous_system(1)	2	Lung NSC(77;0.0137)				L-Cysteine(DB00151)|L-Glutamic Acid(DB00142)	GATTTTCTTCTAATATAGAAG	0.443			NA											15	173					0	0	0.003163	0	0
GFRAL	389400	broad.mit.edu	37	6	55198661	55198661	+	Missense_Mutation	SNP	C	C	G			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr6:55198661C>G	uc003pcm.1	+	3	321	c.235C>G	c.(235-237)CAA>GAA	p.Q79E		NM_207410	NP_997293	Q6UXV0	GFRAL_HUMAN	GDNF family receptor alpha like precursor	79	Extracellular (Potential).					integral to membrane	receptor activity			ovary(1)|breast(1)	2	Lung NSC(77;0.0875)|Renal(3;0.122)		LUSC - Lung squamous cell carcinoma(124;0.23)			AAGCAATTTCCAATTTAAAGA	0.348			NA											23	91					0	0	0.014323	0	0
RIMS1	22999	broad.mit.edu	37	6	72960115	72960115	+	Missense_Mutation	SNP	G	G	A			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr6:72960115G>A	uc003pga.2	+	13	2401	c.2324G>A	c.(2323-2325)GGA>GAA	p.G775E	RIMS1_uc011dyb.1_Missense_Mutation_p.G401E|RIMS1_uc003pgc.2_Missense_Mutation_p.G401E|RIMS1_uc010kaq.2_Missense_Mutation_p.G249E|RIMS1_uc011dyc.1_Missense_Mutation_p.G249E|RIMS1_uc010kar.2_Missense_Mutation_p.G168E|RIMS1_uc011dyd.1_Missense_Mutation_p.G234E|RIMS1_uc003pgf.2_5'UTR|RIMS1_uc003pgg.2_5'UTR|RIMS1_uc003pgi.2_5'UTR|RIMS1_uc003pgh.2_5'UTR|RIMS1_uc003pgd.2_5'UTR|RIMS1_uc003pge.2_5'UTR|RIMS1_uc011dye.1_5'Flank|RIMS1_uc003pgb.3_Missense_Mutation_p.G401E|RIMS1_uc010kas.1_Missense_Mutation_p.G234E	NM_014989	NP_055804	Q86UR5	RIMS1_HUMAN	regulating synaptic membrane exocytosis 1	775	C2 1.				calcium ion-dependent exocytosis|cellular membrane fusion|glutamate secretion|intracellular protein transport|protein complex assembly|regulated secretory pathway|response to stimulus|synaptic vesicle exocytosis|visual perception	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			ovary(7)|pancreas(2)|breast(1)	10		all_epithelial(107;0.179)|all_hematologic(105;0.212)				AGAGTAGATGGACGTCCTCGA	0.348			NA											4	18					0	0	0.009096	0	0
COL12A1	1303	broad.mit.edu	37	6	75840577	75840577	+	Missense_Mutation	SNP	C	C	A			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr6:75840577C>A	uc003phs.2	-	36	6224	c.6058G>T	c.(6058-6060)GGC>TGC	p.G2020C	COL12A1_uc003pht.2_Missense_Mutation_p.G856C	NM_004370	NP_004361	Q99715	COCA1_HUMAN	collagen, type XII, alpha 1 long isoform	2020	Fibronectin type-III 15.				cell adhesion|collagen fibril organization|skeletal system development	collagen type XII|extracellular space	extracellular matrix structural constituent conferring tensile strength			ovary(6)|large_intestine(1)|breast(1)|skin(1)	9						CGCGTTCGGCCCTGGGCAGGG	0.567			NA											12	46					0.00010058	0.00011441	0.013537	1	0
MRAP2	112609	broad.mit.edu	37	6	84799141	84799141	+	Missense_Mutation	SNP	C	C	A			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr6:84799141C>A	uc003pkg.3	+	4	749	c.559C>A	c.(559-561)CCA>ACA	p.P187T	MRAP2_uc010kbo.2_Missense_Mutation_p.P101T	NM_138409	NP_612418	Q96G30	MRAP2_HUMAN	melanocortin 2 receptor accessory protein 2	187					positive regulation of cAMP biosynthetic process|protein localization at cell surface	endoplasmic reticulum|plasma membrane	corticotropin hormone receptor binding|type 1 melanocortin receptor binding|type 3 melanocortin receptor binding|type 4 melanocortin receptor binding|type 5 melanocortin receptor binding			skin(2)	2						GATTTCTGAACCACCTATTGT	0.463			NA											9	53					3.86212e-05	4.47304e-05	0.008291	1	0
TBX18	9096	broad.mit.edu	37	6	85447051	85447051	+	Silent	SNP	G	G	A			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr6:85447051G>A	uc003pkl.1	-	8	1176	c.1176C>T	c.(1174-1176)GGC>GGT	p.G392G	TBX18_uc010kbq.1_Intron	NM_001080508	NP_001073977	O95935	TBX18_HUMAN	T-box 18	392					multicellular organismal development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(2)|pancreas(2)|lung(1)	5		all_cancers(76;0.000283)|Acute lymphoblastic leukemia(125;3.66e-08)|all_hematologic(105;8.61e-05)|all_epithelial(107;0.0858)		BRCA - Breast invasive adenocarcinoma(108;0.0267)		AGCAAGAGGAGCCAGACAAAA	0.552			NA											10	57					0	0	0.010729	0	0
LAMA4	3910	broad.mit.edu	37	6	112457342	112457342	+	Missense_Mutation	SNP	C	C	G			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr6:112457342C>G	uc003pvu.2	-	25	3706	c.3397G>C	c.(3397-3399)GAT>CAT	p.D1133H	LAMA4_uc003pvv.2_Missense_Mutation_p.D1126H|LAMA4_uc003pvt.2_Missense_Mutation_p.D1126H	NM_001105206	NP_001098676	Q16363	LAMA4_HUMAN	laminin, alpha 4 isoform 1 precursor	1133	Laminin G-like 2.				cell adhesion|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	extracellular matrix structural constituent|receptor binding			ovary(4)|breast(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	9		all_cancers(87;0.000196)|all_hematologic(75;0.000114)|all_epithelial(87;0.00542)|Colorectal(196;0.0209)		all cancers(137;0.0335)|OV - Ovarian serous cystadenocarcinoma(136;0.0578)|Epithelial(106;0.0748)|BRCA - Breast invasive adenocarcinoma(108;0.242)		TATTTTGCATCATTAATTTGA	0.368			NA											6	26					0	0	0.001984	0	0
GPRC6A	222545	broad.mit.edu	37	6	117121757	117121757	+	Missense_Mutation	SNP	C	C	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr6:117121757C>T	uc003pxj.1	-	4	1560	c.1538G>A	c.(1537-1539)AGG>AAG	p.R513K	GPRC6A_uc003pxk.1_Missense_Mutation_p.R338K|GPRC6A_uc003pxl.1_Intron	NM_148963	NP_683766	Q5T6X5	GPC6A_HUMAN	G protein-coupled receptor, family C, group 6,	513	Extracellular (Potential).				response to amino acid stimulus		G-protein coupled receptor activity			ovary(4)|skin(2)	6		all_cancers(87;0.0314)|all_epithelial(87;0.0216)|Colorectal(196;0.234)		GBM - Glioblastoma multiforme(226;0.0265)|all cancers(137;0.0554)|OV - Ovarian serous cystadenocarcinoma(136;0.07)		CTTAAGATTCCTGAACTCATT	0.308			NA											14	45					0	0	0.00245	0	0
VNN2	8875	broad.mit.edu	37	6	133072284	133072284	+	Missense_Mutation	SNP	C	C	A			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr6:133072284C>A	uc003qdt.2	-	5	1211	c.1200G>T	c.(1198-1200)CAG>CAT	p.Q400H	VNN2_uc003qds.2_Missense_Mutation_p.Q109H|VNN2_uc010kgb.2_Intron|VNN2_uc003qdv.2_Missense_Mutation_p.Q347H	NM_004665	NP_004656	O95498	VNN2_HUMAN	vanin 2 isoform 1 precursor	400					cellular component movement|pantothenate metabolic process	anchored to membrane|plasma membrane	pantetheine hydrolase activity				0				OV - Ovarian serous cystadenocarcinoma(155;0.00237)|GBM - Glioblastoma multiforme(226;0.0267)		CTGAAATTACCTGCCAGTACT	0.373			NA											14	74					1.49906e-05	1.77162e-05	0.00245	1	0
KIAA1244	57221	broad.mit.edu	37	6	138628520	138628520	+	Missense_Mutation	SNP	G	G	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr6:138628520G>T	uc003qhu.2	+	23	3959	c.3959G>T	c.(3958-3960)GGT>GTT	p.G1320V		NM_020340	NP_065073	Q5TH69	BIG3_HUMAN	brefeldin A-inhibited guanine	1320					regulation of ARF protein signal transduction	cytoplasm|integral to membrane	ARF guanyl-nucleotide exchange factor activity			ovary(1)|skin(1)	2	Breast(32;0.135)			OV - Ovarian serous cystadenocarcinoma(155;0.00102)|GBM - Glioblastoma multiforme(68;0.00259)		TACCTGGTTGGTGACTACTCC	0.433			NA											13	93					4.36969e-10	6.41358e-10	0.001855	1	0
FUCA2	2519	broad.mit.edu	37	6	143823540	143823540	+	Missense_Mutation	SNP	C	C	G			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr6:143823540C>G	uc003qjm.2	-	4	1007	c.915G>C	c.(913-915)AGG>AGC	p.R305S	FUCA2_uc003qjn.2_Missense_Mutation_p.R59S	NM_032020	NP_114409	Q9BTY2	FUCO2_HUMAN	fucosidase, alpha-L- 2, plasma precursor	305					fucose metabolic process	extracellular region	alpha-L-fucosidase activity|cation binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(155;7.45e-06)|GBM - Glioblastoma multiforme(68;0.0142)		CAGCTTCCCTCCTATAGCCCC	0.408			NA											8	190					0	0	0.006214	0	0
STXBP5	134957	broad.mit.edu	37	6	147704039	147704039	+	Missense_Mutation	SNP	G	G	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr6:147704039G>T	uc003qlz.2	+	27	3480	c.3319G>T	c.(3319-3321)GCA>TCA	p.A1107S	STXBP5_uc010khz.1_Missense_Mutation_p.A1071S|STXBP5_uc003qlx.2_RNA|STXBP5_uc003qly.2_Missense_Mutation_p.A762S	NM_001127715	NP_001121187	Q5T5C0	STXB5_HUMAN	syntaxin binding protein 5 (tomosyn) isoform b	1107	v-SNARE coiled-coil homology.				exocytosis|positive regulation of exocytosis|protein transport	cell junction|cytoplasmic vesicle membrane|nicotinic acetylcholine-gated receptor-channel complex|synaptic vesicle	syntaxin-1 binding				0		Ovarian(120;0.0164)		OV - Ovarian serous cystadenocarcinoma(155;1.77e-09)|GBM - Glioblastoma multiforme(68;0.0694)		AGCCAGGCTGGCACTAGATGA	0.498			NA											18	123					9.16793e-09	1.29777e-08	0.00499	1	0
UST	10090	broad.mit.edu	37	6	149340286	149340286	+	Missense_Mutation	SNP	G	G	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr6:149340286G>T	uc003qmg.2	+	6	989	c.693G>T	c.(691-693)GAG>GAT	p.E231D		NM_005715	NP_005706	Q9Y2C2	UST_HUMAN	uronyl-2-sulfotransferase	231	Lumenal (Potential).				protein sulfation	Golgi membrane|integral to membrane	sulfotransferase activity			ovary(2)	2		Ovarian(120;0.0907)		OV - Ovarian serous cystadenocarcinoma(155;1.78e-10)|GBM - Glioblastoma multiforme(68;0.138)		ATATCAATGAGTGTATTCTTG	0.408			NA											10	72					2.17888e-05	2.55607e-05	0.006214	1	0
SYNE1	23345	broad.mit.edu	37	6	152737815	152737815	+	Silent	SNP	T	T	C			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr6:152737815T>C	uc010kiw.2	-	41	6359	c.5757A>G	c.(5755-5757)TTA>TTG	p.L1919L	SYNE1_uc003qot.3_Silent_p.L1926L|SYNE1_uc003qou.3_Silent_p.L1919L|SYNE1_uc010kjb.1_Silent_p.L1902L	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	1919	Cytoplasmic (Potential).|Potential.				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		CAGCAGATTCTAATGCTTTAG	0.458			NA								HNSCC(10;0.0054)			13	76					0	0	0.013537	0	0
MYCT1	80177	broad.mit.edu	37	6	153043182	153043182	+	Missense_Mutation	SNP	C	C	A			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr6:153043182C>A	uc003qpd.3	+	2	510	c.502C>A	c.(502-504)CAT>AAT	p.H168N	MYCT1_uc010kjc.1_Missense_Mutation_p.H120N|MYCT1_uc003qpc.3_Missense_Mutation_p.H168N	NM_025107	NP_079383	Q8N699	MYCT1_HUMAN	myc target 1	168						nucleus				ovary(1)	1		Ovarian(120;0.0654)		OV - Ovarian serous cystadenocarcinoma(155;1.33e-10)|BRCA - Breast invasive adenocarcinoma(81;0.143)		TTCTACTTTCCATCCCTTTCT	0.493			NA											15	82					2.61681e-11	4.01665e-11	0.00245	1	0
ARID1B	57492	broad.mit.edu	37	6	157527447	157527447	+	Missense_Mutation	SNP	G	G	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr6:157527447G>T	uc003qqn.2	+	20	5270	c.5118G>T	c.(5116-5118)TTG>TTT	p.L1706F	ARID1B_uc003qqo.2_Missense_Mutation_p.L1666F|ARID1B_uc003qqp.2_Missense_Mutation_p.L1653F	NM_017519	NP_059989	Q8NFD5	ARI1B_HUMAN	AT rich interactive domain 1B (SWI1-like)	1711					chromatin-mediated maintenance of transcription|nervous system development|transcription, DNA-dependent	SWI/SNF complex	DNA binding|protein binding|transcription coactivator activity			ovary(1)|breast(1)	2		Breast(66;0.000162)|Ovarian(120;0.0265)		OV - Ovarian serous cystadenocarcinoma(65;3.19e-17)|BRCA - Breast invasive adenocarcinoma(81;1.01e-05)		GCCAGTCCTTGGCAGACGATT	0.478			NA											42	273					2.13384e-23	3.95132e-23	0.01441	1	0
ARID1B	57492	broad.mit.edu	37	6	157528318	157528318	+	Missense_Mutation	SNP	G	G	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr6:157528318G>T	uc003qqn.2	+	20	6141	c.5989G>T	c.(5989-5991)GAC>TAC	p.D1997Y	ARID1B_uc003qqo.2_Missense_Mutation_p.D1957Y|ARID1B_uc003qqp.2_Missense_Mutation_p.D1944Y	NM_017519	NP_059989	Q8NFD5	ARI1B_HUMAN	AT rich interactive domain 1B (SWI1-like)	2002					chromatin-mediated maintenance of transcription|nervous system development|transcription, DNA-dependent	SWI/SNF complex	DNA binding|protein binding|transcription coactivator activity			ovary(1)|breast(1)	2		Breast(66;0.000162)|Ovarian(120;0.0265)		OV - Ovarian serous cystadenocarcinoma(65;3.19e-17)|BRCA - Breast invasive adenocarcinoma(81;1.01e-05)		GTGGTGGTGGGACTGCCTCGA	0.547			NA											19	126					1.01871e-10	1.53409e-10	0.008871	1	0
IGF2R	3482	broad.mit.edu	37	6	160468236	160468236	+	Silent	SNP	A	A	G			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr6:160468236A>G	uc003qta.2	+	16	2245	c.2097A>G	c.(2095-2097)TCA>TCG	p.S699S		NM_000876	NP_000867	P11717	MPRI_HUMAN	insulin-like growth factor 2 receptor precursor	699	5.|Lumenal (Potential).				receptor-mediated endocytosis	cell surface|endocytic vesicle|endosome|integral to plasma membrane|lysosomal membrane|trans-Golgi network transport vesicle	glycoprotein binding|insulin-like growth factor receptor activity|phosphoprotein binding|transporter activity			ovary(3)	3		Breast(66;0.000777)|Ovarian(120;0.0305)		OV - Ovarian serous cystadenocarcinoma(65;2.45e-17)|BRCA - Breast invasive adenocarcinoma(81;1.09e-05)		CGAAGCTTTCATATTATGATG	0.458			NA											11	58					0	0	0.008291	0	0
C6orf118	168090	broad.mit.edu	37	6	165715274	165715274	+	Silent	SNP	C	C	A			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr6:165715274C>A	uc003qum.3	-	2	573	c.537G>T	c.(535-537)CTG>CTT	p.L179L	C6orf118_uc011egi.1_RNA	NM_144980	NP_659417	Q5T5N4	CF118_HUMAN	hypothetical protein LOC168090	179											0		Breast(66;6.27e-05)|Ovarian(120;0.0228)|Prostate(117;0.0906)|all_neural(5;0.157)		OV - Ovarian serous cystadenocarcinoma(33;3.23e-18)|BRCA - Breast invasive adenocarcinoma(81;3.11e-06)|GBM - Glioblastoma multiforme(31;0.000313)		TCAAGTCGGGCAGCCGGAGTT	0.647			NA											22	69					1.96292e-10	2.92145e-10	0.010504	1	0
TCP10L2	401285	broad.mit.edu	37	6	167595301	167595301	+	Missense_Mutation	SNP	G	G	A			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr6:167595301G>A	uc010kkp.2	+	8	1090	c.959G>A	c.(958-960)CGA>CAA	p.R320Q		NM_001145121	NP_001138593	B9ZVM9	B9ZVM9_HUMAN	t-complex 10-like 2	320											0						GAAGAAAAACGACATCCAAAT	0.527			NA											5	42					0	0	0.000602	0	0
FRMD1	79981	broad.mit.edu	37	6	168479740	168479740	+	Missense_Mutation	SNP	G	G	T	rs147876520		TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr6:168479740G>T	uc003qwo.3	-	1	100	c.35C>A	c.(34-36)CCC>CAC	p.P12H		NM_024919	NP_079195	Q8N878	FRMD1_HUMAN	FERM domain containing 1 isoform 1	12						cytoskeleton	binding			ovary(1)	1		Breast(66;1.07e-05)|Ovarian(120;0.0728)		Epithelial(4;7.7e-30)|OV - Ovarian serous cystadenocarcinoma(33;5.82e-22)|BRCA - Breast invasive adenocarcinoma(4;1.38e-10)|GBM - Glioblastoma multiforme(31;0.000756)		TGTCCGGGCGGGGTCTATGCC	0.662	GBM(50;8 1094 9538 34399)|Ovarian(80;676 1857 8675 49015)		NA											13	49					2.27111e-07	2.99523e-07	0.013537	1	0
SUN1	23353	broad.mit.edu	37	7	909028	909028	+	Nonsense_Mutation	SNP	C	C	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr7:909028C>T	uc011jvp.1	+	18	2102	c.2023C>T	c.(2023-2025)CAG>TAG	p.Q675*	GET4_uc003sjj.1_Intron|SUN1_uc003sjf.2_Nonsense_Mutation_p.Q592*|SUN1_uc011jvq.1_Nonsense_Mutation_p.Q572*|SUN1_uc003sjg.2_Nonsense_Mutation_p.Q580*|SUN1_uc011jvr.1_Nonsense_Mutation_p.Q473*|SUN1_uc003sji.2_Nonsense_Mutation_p.Q513*|SUN1_uc003sjk.2_Nonsense_Mutation_p.Q314*	NM_001130965	NP_001124437	O94901	SUN1_HUMAN	unc-84 homolog A isoform a	702	Perinuclear space.|SUN.				cytoskeletal anchoring at nuclear membrane|nuclear matrix anchoring at nuclear membrane	integral to membrane|nuclear inner membrane|SUN-KASH complex	protein binding				0						TAAAGGCTCCCAGGGGTACCT	0.547			NA											33	155					0	0	0.013726	0	0
DGKB	1607	broad.mit.edu	37	7	14724966	14724966	+	Missense_Mutation	SNP	G	G	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr7:14724966G>T	uc003ssz.2	-	9	920	c.733C>A	c.(733-735)CAC>AAC	p.H245N	DGKB_uc011jxt.1_Missense_Mutation_p.H238N|DGKB_uc003sta.2_Missense_Mutation_p.H245N|DGKB_uc011jxu.1_Missense_Mutation_p.H245N|DGKB_uc011jxv.1_Missense_Mutation_p.H245N	NM_004080	NP_004071	Q9Y6T7	DGKB_HUMAN	diacylglycerol kinase, beta isoform 1	245	Phorbol-ester/DAG-type 1.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	cytoplasm|plasma membrane	ATP binding|calcium ion binding|diacylglycerol kinase activity|protein binding			lung(5)|ovary(4)|breast(2)|skin(1)	12					Phosphatidylserine(DB00144)	CGCCACACGTGCTGTCCATCA	0.463			NA											11	63					2.80697e-09	4.01807e-09	0.010729	1	0
HOXA13	3209	broad.mit.edu	37	7	27238029	27238029	+	Missense_Mutation	SNP	A	A	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr7:27238029A>T	uc003szb.1	-	2	984	c.955T>A	c.(955-957)TAT>AAT	p.Y319N	uc003szc.1_5'Flank	NM_000522	NP_000513	P31271	HXA13_HUMAN	homeobox A13	319					skeletal system development	nucleus	sequence-specific DNA binding			breast(1)	1						CCCCTCCTATAGGAGCTGGCA	0.517			NA	T	NUP98	AML						OREG0003748	type=REGULATORY REGION|Gene=HOXA13|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	19	101					0	0	0.006122	0	0
AMPH	273	broad.mit.edu	37	7	38433709	38433709	+	Missense_Mutation	SNP	C	C	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr7:38433709C>T	uc003tgu.2	-	18	1573	c.1504G>A	c.(1504-1506)GGG>AGG	p.G502R	AMPH_uc003tgv.2_Missense_Mutation_p.G460R|AMPH_uc003tgt.2_Missense_Mutation_p.G387R|AMPH_uc003tgw.1_Missense_Mutation_p.G525R|AMPH_uc010kxl.1_RNA	NM_001635	NP_001626	P49418	AMPH_HUMAN	amphiphysin isoform 1	502					endocytosis|synaptic transmission	actin cytoskeleton|cell junction|synaptic vesicle membrane				ovary(3)|liver(1)|skin(1)	5						ACTCCTTCCCCGGCAGGGACA	0.582			NA											27	147					0	0	0.007291	0	0
URGCP	55665	broad.mit.edu	37	7	43916860	43916860	+	Silent	SNP	T	T	C			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr7:43916860T>C	uc003tiw.2	-	6	2259	c.2202A>G	c.(2200-2202)ACA>ACG	p.T734T	URGCP_uc003tiu.2_Silent_p.T691T|URGCP_uc003tiv.2_Silent_p.T659T|URGCP_uc003tix.2_Silent_p.T725T|URGCP_uc003tiy.2_Silent_p.T691T|URGCP_uc003tiz.2_Silent_p.T691T|URGCP_uc011kbj.1_Silent_p.T691T	NM_001077663	NP_001071131	Q8TCY9	URGCP_HUMAN	up-regulated gene 4 isoform 3	734					cell cycle	centrosome|nucleus	GTP binding			ovary(2)|liver(1)|skin(1)	4						CCTCAGCCACTGTGATGAGCT	0.612			NA											19	60					0	0	0.007413	0	0
URGCP	55665	broad.mit.edu	37	7	43917673	43917673	+	Missense_Mutation	SNP	G	G	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr7:43917673G>T	uc003tiw.2	-	6	1446	c.1389C>A	c.(1387-1389)GAC>GAA	p.D463E	URGCP_uc003tiu.2_Missense_Mutation_p.D420E|URGCP_uc003tiv.2_Missense_Mutation_p.D388E|URGCP_uc003tix.2_Missense_Mutation_p.D454E|URGCP_uc003tiy.2_Missense_Mutation_p.D420E|URGCP_uc003tiz.2_Missense_Mutation_p.D420E|URGCP_uc011kbj.1_Missense_Mutation_p.D420E	NM_001077663	NP_001071131	Q8TCY9	URGCP_HUMAN	up-regulated gene 4 isoform 3	463					cell cycle	centrosome|nucleus	GTP binding			ovary(2)|liver(1)|skin(1)	4						CACAGTCCTCGTCGACCTTTA	0.592			NA											35	149					2.49991e-28	4.69748e-28	0.003271	1	0
CDC14C	168448	broad.mit.edu	37	7	48964880	48964880	+	Silent	SNP	C	C	A			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr7:48964880C>A	uc010kyv.1	+	1	724	c.612C>A	c.(610-612)GCC>GCA	p.A204A		NR_003595				SubName: Full=Putative uncharacterized protein MGC26484;												0						ATTCAAGAGCCAGACTTGAAA	0.353			NA											10	30					3.07112e-06	3.81345e-06	0.010729	1	0
GTF2IRD2P1	401375	broad.mit.edu	37	7	72658179	72658179	+	Missense_Mutation	SNP	T	T	C	rs147293416	by1000genomes	TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr7:72658179T>C	uc003txs.1	-	13	1733	c.805A>G	c.(805-807)AAA>GAA	p.K269E	FKBP6_uc003twz.2_Intron	NR_002164				RecName: Full=General transcription factor II-I repeat domain-containing protein 2B; AltName: Full=GTF2I repeat domain-containing protein 2B; AltName: Full=Transcription factor GTF2IRD2-beta;												0						cagagtgatttcggatgaatt	0			NA											5	62					0	0	0.00308	0	0
YWHAG	7532	broad.mit.edu	37	7	75959153	75959153	+	Missense_Mutation	SNP	T	T	A			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr7:75959153T>A	uc011kgj.1	-	2	702	c.485A>T	c.(484-486)AAA>ATA	p.K162I		NM_012479	NP_036611	P61981	1433G_HUMAN	tyrosine 3-monooxygenase/tryptophan	162					G2/M transition of mitotic cell cycle|regulation of neuron differentiation|regulation of signal transduction|regulation of synaptic plasticity	cytosol	insulin-like growth factor receptor binding|protein kinase C binding|protein kinase C inhibitor activity			ovary(1)|lung(1)	2						CATGTGCTCTTTGCTGATCTC	0.587			NA											42	186					0	0	0.011902	0	0
DTX2	113878	broad.mit.edu	37	7	76111844	76111844	+	Silent	SNP	G	G	A			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr7:76111844G>A	uc003uff.3	+	5	844	c.288G>A	c.(286-288)CGG>CGA	p.R96R	DTX2_uc011kgk.1_Silent_p.R5R|DTX2_uc003ufg.3_Silent_p.R96R|DTX2_uc003ufh.3_Silent_p.R96R|DTX2_uc003ufj.3_Silent_p.R96R	NM_020892	NP_065943	Q86UW9	DTX2_HUMAN	deltex 2 isoform a	96	WWE 1.				Notch signaling pathway	cytoplasm|nucleus	protein binding|zinc ion binding			ovary(1)|skin(1)	2						GGGCTGTGCGGAGACACCTGT	0.552			NA											20	90					0	0	0.008871	0	0
PCLO	27445	broad.mit.edu	37	7	82545660	82545660	+	Missense_Mutation	SNP	G	G	C			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr7:82545660G>C	uc003uhx.2	-	7	11931	c.11642C>G	c.(11641-11643)CCG>CGG	p.P3881R	PCLO_uc003uhv.2_Missense_Mutation_p.P3881R|PCLO_uc010lec.2_Missense_Mutation_p.P846R	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	3812	Gln-rich.				cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						AGGACTTGTCGGAGGAACTAG	0.463			NA											61	386					0	0	0.01441	0	0
DMTF1	9988	broad.mit.edu	37	7	86824364	86824364	+	Missense_Mutation	SNP	C	C	A			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr7:86824364C>A	uc003uih.2	+	18	2517	c.2191C>A	c.(2191-2193)CAT>AAT	p.H731N	DMTF1_uc003uii.2_Missense_Mutation_p.H465N|DMTF1_uc003uij.2_Missense_Mutation_p.H465N|DMTF1_uc011khb.1_Missense_Mutation_p.H643N|DMTF1_uc003uik.2_RNA|DMTF1_uc003uil.2_Missense_Mutation_p.H731N|DMTF1_uc003uin.2_Missense_Mutation_p.H465N	NM_001142327	NP_001135799	Q9Y222	DMTF1_HUMAN	cyclin D binding myb-like transcription factor 1	731	Interaction with CCND1, CCND2 and CCND3 (By similarity).|Required for transcriptional activation (By similarity).				cell cycle	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|central_nervous_system(1)	2	Esophageal squamous(14;0.0058)					ACTCCAACATCATCAGGAAGA	0.338			NA											7	58					8.12818e-05	9.31233e-05	0.001984	1	0
BUD31	8896	broad.mit.edu	37	7	99015095	99015095	+	Missense_Mutation	SNP	C	C	G			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr7:99015095C>G	uc003uqf.2	+	5	462	c.261C>G	c.(259-261)AAC>AAG	p.N87K	BUD31_uc011kiu.1_Missense_Mutation_p.N87K|BUD31_uc011kiv.1_Missense_Mutation_p.N87K|BUD31_uc003uqg.3_Missense_Mutation_p.N87K	NM_003910	NP_003901	P41223	BUD31_HUMAN	G10 protein	87					regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding transcription factor activity			ovary(1)	1	all_cancers(62;1.76e-08)|all_epithelial(64;1.63e-09)|Lung NSC(181;0.0053)|all_lung(186;0.00895)|Esophageal squamous(72;0.0166)		STAD - Stomach adenocarcinoma(171;0.215)			CAGACAAAAACCTGATTGCAA	0.463			NA											6	36					0	0	0.001168	0	0
PTCD1	26024	broad.mit.edu	37	7	99030992	99030992	+	Missense_Mutation	SNP	C	C	A	rs10258918	byFrequency	TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr7:99030992C>A	uc003uqh.2	-	3	634	c.503G>T	c.(502-504)CGA>CTA	p.R168L	PTCD1_uc011kiw.1_Missense_Mutation_p.R217L	NM_015545	NP_056360	O75127	PTCD1_HUMAN	pentatricopeptide repeat domain 1	168	PPR 1.									ovary(1)	1	all_cancers(62;2.54e-08)|all_epithelial(64;2.55e-09)|Lung NSC(181;0.0053)|all_lung(186;0.00895)|Esophageal squamous(72;0.0166)		STAD - Stomach adenocarcinoma(171;0.215)			GGGCTGCAATCGCTCCTCCTT	0.567			NA											28	143					2.12542e-12	3.38472e-12	0.00632	1	0
TRIM56	81844	broad.mit.edu	37	7	100732499	100732499	+	Missense_Mutation	SNP	G	G	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr7:100732499G>T	uc003uxq.2	+	3	2137	c.1906G>T	c.(1906-1908)GCG>TCG	p.A636S	TRIM56_uc003uxr.2_Intron	NM_030961	NP_112223	Q9BRZ2	TRI56_HUMAN	tripartite motif-containing 56	636					defense response to virus|interferon-beta production|protein K63-linked ubiquitination|response to type I interferon	cytoplasm	ubiquitin-protein ligase activity|zinc ion binding			kidney(1)|central_nervous_system(1)|skin(1)	3	Lung NSC(181;0.136)|all_lung(186;0.182)					GGGCCTGCGGGCGCTGGTGTT	0.647	Ovarian(89;1092 1379 22756 38989 39611)		NA											26	118					5.45024e-15	9.20903e-15	0.00333	1	0
RELN	5649	broad.mit.edu	37	7	103151413	103151413	+	Missense_Mutation	SNP	T	T	A			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr7:103151413T>A	uc003vca.2	-	51	8319	c.8159A>T	c.(8158-8160)GAA>GTA	p.E2720V	RELN_uc010liz.2_Missense_Mutation_p.E2720V	NM_005045	NP_005036	P78509	RELN_HUMAN	reelin isoform a	2720					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			ovary(8)|upper_aerodigestive_tract(5)|large_intestine(2)|central_nervous_system(2)|skin(1)|pancreas(1)	19				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		ACAGAATCTTTCTACTGTACA	0.413	NSCLC(146;835 1944 15585 22231 52158)		NA											7	18					0	0	0.00308	0	0
GPR85	54329	broad.mit.edu	37	7	112724029	112724029	+	Missense_Mutation	SNP	C	C	A			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr7:112724029C>A	uc010ljv.2	-	2	1265	c.748G>T	c.(748-750)GGT>TGT	p.G250C	GPR85_uc003vgp.1_Missense_Mutation_p.G250C|GPR85_uc003vgq.2_Missense_Mutation_p.G250C|GPR85_uc010ljw.1_Missense_Mutation_p.G250C	NM_001146266	NP_001139738	P60893	GPR85_HUMAN	G protein-coupled receptor 85	250	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(1)|central_nervous_system(1)	2						GGTGTGGGACCCCTTCCAAAT	0.522			NA											37	167					3.93418e-24	7.30634e-24	0.004289	1	0
PPP1R3A	5506	broad.mit.edu	37	7	113558946	113558946	+	Missense_Mutation	SNP	C	C	A			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr7:113558946C>A	uc010ljy.1	-	1	137	c.106G>T	c.(106-108)GGT>TGT	p.G36C		NM_002711	NP_002702	Q16821	PPR3A_HUMAN	protein phosphatase 1, regulatory (inhibitor)	36					glycogen metabolic process	integral to membrane				lung(9)|ovary(9)|pancreas(7)|skin(6)|breast(2)|prostate(1)	34						GGGGAGAAACCAGGTTGGAAA	0.388			NA											13	86					3.27435e-08	4.48551e-08	0.00245	1	0
KCND2	3751	broad.mit.edu	37	7	119915431	119915431	+	Missense_Mutation	SNP	G	G	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr7:119915431G>T	uc003vjj.1	+	1	1710	c.745G>T	c.(745-747)GCT>TCT	p.A249S		NM_012281	NP_036413	Q9NZV8	KCND2_HUMAN	potassium voltage-gated channel, Shal-related	249	Cytoplasmic (Potential).				regulation of action potential|synaptic transmission	cell surface|dendritic spine	metal ion binding			ovary(2)|central_nervous_system(2)|skin(1)	5	all_neural(327;0.117)					GCTTCGCCTGGCTGCAGCGCC	0.517			NA											13	64					5.50884e-06	6.65869e-06	0.013537	1	0
GRM8	2918	broad.mit.edu	37	7	126086184	126086184	+	Silent	SNP	G	G	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr7:126086184G>T	uc003vlr.2	-	9	2984	c.2673C>A	c.(2671-2673)ACC>ACA	p.T891T	GRM8_uc003vls.2_RNA|GRM8_uc011kof.1_RNA|GRM8_uc003vlt.2_Silent_p.T891T|GRM8_uc010lkz.1_RNA	NM_000845	NP_000836	O00222	GRM8_HUMAN	glutamate receptor, metabotropic 8 isoform a	891	Cytoplasmic (Potential).				negative regulation of cAMP biosynthetic process|sensory perception of smell|visual perception	integral to plasma membrane				lung(15)|ovary(5)|pancreas(1)|breast(1)|skin(1)	23		Prostate(267;0.186)			L-Glutamic Acid(DB00142)	ACTTACTGTTGGTTTCAAGAC	0.453			NA								HNSCC(24;0.065)			30	151					5.90632e-09	8.39805e-09	0.012213	1	0
PLXNA4	91584	broad.mit.edu	37	7	132192798	132192798	+	Missense_Mutation	SNP	G	G	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr7:132192798G>T	uc003vra.3	-	2	884	c.655C>A	c.(655-657)CAT>AAT	p.H219N	PLXNA4_uc003vrc.2_Missense_Mutation_p.H219N|PLXNA4_uc003vrb.2_Missense_Mutation_p.H219N	NM_020911	NP_065962	Q9HCM2	PLXA4_HUMAN	plexin A4 isoform 1	219	Extracellular (Potential).|Sema.					integral to membrane|intracellular|plasma membrane				ovary(1)	1						AACTCATCATGGAAGACGTAC	0.507			NA											17	118					6.49762e-13	1.0452e-12	0.006122	1	0
EPHB6	2051	broad.mit.edu	37	7	142561931	142561931	+	Silent	SNP	C	C	A			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr7:142561931C>A	uc011kst.1	+	7	1160	c.373C>A	c.(373-375)CGG>AGG	p.R125R	EPHB6_uc011ksu.1_Silent_p.R125R|EPHB6_uc003wbs.2_5'UTR|EPHB6_uc003wbt.2_5'UTR|EPHB6_uc003wbu.2_5'UTR	NM_004445	NP_004436	O15197	EPHB6_HUMAN	ephrin receptor EphB6 precursor	125	Extracellular (Potential).					extracellular region|integral to plasma membrane	ATP binding|ephrin receptor activity			lung(8)|large_intestine(4)|central_nervous_system(3)|stomach(1)|skin(1)|ovary(1)|pancreas(1)	19	Melanoma(164;0.059)					CGGCACCTGCCGGGAGACCTT	0.637			NA											35	131					7.11191e-15	1.19533e-14	0.013726	1	0
OR6V1	346517	broad.mit.edu	37	7	142750269	142750269	+	Missense_Mutation	SNP	G	G	A			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr7:142750269G>A	uc011ksv.1	+	1	832	c.832G>A	c.(832-834)GTT>ATT	p.V278I		NM_001001667	NP_001001667	Q8N148	OR6V1_HUMAN	olfactory receptor, family 6, subfamily V,	278	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	Melanoma(164;0.059)					GGTGACTTCAGTTCTCACCCC	0.493			NA											13	61					0	0	0.013537	0	0
TAS2R60	338398	broad.mit.edu	37	7	143141079	143141079	+	Missense_Mutation	SNP	G	G	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr7:143141079G>T	uc011ktg.1	+	1	534	c.534G>T	c.(532-534)TGG>TGT	p.W178C	uc003wda.2_Intron	NM_177437	NP_803186	P59551	T2R60_HUMAN	taste receptor, type 2, member 60	178	Extracellular (Potential).				sensory perception of bitter taste	integral to membrane	G-protein coupled receptor activity			skin(6)	6	Melanoma(164;0.172)					TACAACCTTGGAATGTCACTG	0.413			NA											27	158					5.61819e-17	9.91353e-17	0.005443	1	0
OR6B1	135946	broad.mit.edu	37	7	143701858	143701858	+	Missense_Mutation	SNP	T	T	C			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr7:143701858T>C	uc003wdt.1	+	1	769	c.769T>C	c.(769-771)TAT>CAT	p.Y257H		NM_001005281	NP_001005281	O95007	OR6B1_HUMAN	olfactory receptor, family 6, subfamily B,	257	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	Melanoma(164;0.0783)					TATTTTCATGTATGCTCGACC	0.423			NA											13	123					0	0	0.013537	0	0
ATG9B	285973	broad.mit.edu	37	7	150715032	150715032	+	Missense_Mutation	SNP	T	T	C			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr7:150715032T>C	uc011kvc.1	-	8	2054	c.1978A>G	c.(1978-1980)ACT>GCT	p.T660A	ATG9B_uc003wig.3_RNA	NM_173681	NP_775952	Q674R7	ATG9B_HUMAN	ATG9 autophagy related 9 homolog B	660	Cytoplasmic (By similarity).				autophagic vacuole assembly	autophagic vacuole membrane|cytoplasmic vesicle|integral to membrane				ovary(1)	1	all_neural(206;0.219)		OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		ACATCCACAGTGAAGTGATGA	0.592			NA									OREG0018444	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	14					0	0	0.009096	0	0
GALNTL5	168391	broad.mit.edu	37	7	151716812	151716812	+	Missense_Mutation	SNP	C	C	A			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr7:151716812C>A	uc003wkp.2	+	9	1481	c.1258C>A	c.(1258-1260)CTG>ATG	p.L420M	GALNTL5_uc003wkq.2_Missense_Mutation_p.L171M|GALNTL5_uc003wkr.2_RNA|GALNTL5_uc003wks.2_RNA|GALNTL5_uc010lqf.2_Missense_Mutation_p.L309M	NM_145292	NP_660335	Q7Z4T8	GLTL5_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide	420	Lumenal (Potential).					Golgi membrane|integral to membrane	transferase activity, transferring glycosyl groups			ovary(2)	2	all_neural(206;0.187)	all_hematologic(28;0.0749)	OV - Ovarian serous cystadenocarcinoma(82;0.00427)	UCEC - Uterine corpus endometrioid carcinoma (81;0.18)|BRCA - Breast invasive adenocarcinoma(188;0.166)		AAGGAAACGACTGGGTTGCAA	0.398			NA											15	48					2.31682e-05	2.70792e-05	0.003163	1	0
MLL3	58508	broad.mit.edu	37	7	151970805	151970805	+	Missense_Mutation	SNP	G	G	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr7:151970805G>T	uc003wla.2	-	7	1216	c.997C>A	c.(997-999)CAA>AAA	p.Q333K		NM_170606	NP_733751	Q8NEZ4	MLL3_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 3	333					intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			large_intestine(27)|pancreas(13)|ovary(9)|central_nervous_system(8)|breast(3)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	63	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)		TCAGGAGCTTGGTCAATGTGT	0.383	Colon(68;14 1149 1884 27689 34759)		NA	N		medulloblastoma								8	202					0.00307968	0.00334771	0.00308	1	0
RBM33	155435	broad.mit.edu	37	7	155538132	155538132	+	Nonsense_Mutation	SNP	G	G	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr7:155538132G>T	uc010lqk.1	+	14	3183	c.2815G>T	c.(2815-2817)GAG>TAG	p.E939*	RBM33_uc011kvv.1_Nonsense_Mutation_p.E748*|RBM33_uc003wmg.2_5'Flank	NM_053043	NP_444271	Q96EV2	RBM33_HUMAN	RNA binding motif protein 33	939							nucleotide binding|RNA binding			ovary(1)	1	all_neural(206;0.101)	all_hematologic(28;0.0592)	OV - Ovarian serous cystadenocarcinoma(82;0.011)	UCEC - Uterine corpus endometrioid carcinoma (81;0.2)		TGCAGATGTGGAGGAGCCAGC	0.552			NA											7	28					2.0095e-06	2.5099e-06	0.001984	1	0
RP1L1	94137	broad.mit.edu	37	8	10466663	10466663	+	Nonsense_Mutation	SNP	C	C	A			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr8:10466663C>A	uc003wtc.2	-	4	5174	c.4945G>T	c.(4945-4947)GAG>TAG	p.E1649*		NM_178857	NP_849188	Q8IWN7	RP1L1_HUMAN	retinitis pigmentosa 1-like 1	1649					intracellular signal transduction					ovary(4)|breast(3)|central_nervous_system(1)	8				COAD - Colon adenocarcinoma(149;0.0811)		TCCGCCTCCTCGCCCAGCTGG	0.682			NA											9	30					3.09899e-07	4.07021e-07	0.004482	1	0
SLC18A1	6570	broad.mit.edu	37	8	20022571	20022571	+	Silent	SNP	G	G	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr8:20022571G>T	uc011kyq.1	-	10	1377	c.906C>A	c.(904-906)ATC>ATA	p.I302I	SLC18A1_uc003wzl.2_Silent_p.I89I|SLC18A1_uc003wzm.2_Silent_p.I302I|SLC18A1_uc011kyr.1_Silent_p.I302I|SLC18A1_uc003wzn.2_Silent_p.I302I|SLC18A1_uc010ltf.2_RNA|SLC18A1_uc003wzo.2_Silent_p.I302I	NM_001135691	NP_001129163	P54219	VMAT1_HUMAN	solute carrier family 18 (vesicular monoamine),	302	Helical; (Potential).				neurotransmitter transport	clathrin sculpted monoamine transport vesicle membrane|integral to membrane|membrane fraction	drug transmembrane transporter activity|monoamine transmembrane transporter activity			ovary(2)	2				Colorectal(74;0.0747)		CAGCCACCAGGATGTAAGGGT	0.537			NA											19	68					3.99206e-14	6.60504e-14	0.007413	1	0
KCNU1	157855	broad.mit.edu	37	8	36698038	36698038	+	Silent	SNP	C	C	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr8:36698038C>T	uc010lvw.2	+	15	1663	c.1576C>T	c.(1576-1578)CTG>TTG	p.L526L	KCNU1_uc003xjw.2_RNA	NM_001031836	NP_001027006	A8MYU2	KCNU1_HUMAN	potassium channel, subfamily U, member 1	526	Cytoplasmic (Potential).					voltage-gated potassium channel complex	binding|large conductance calcium-activated potassium channel activity|voltage-gated potassium channel activity			ovary(1)	1				KIRC - Kidney renal clear cell carcinoma(67;0.0504)|Kidney(114;0.0634)		AAACAAAATTCTGACCCAACG	0.408			NA											5	18					0	0	0.000602	0	0
NPBWR1	2831	broad.mit.edu	37	8	53853025	53853025	+	Silent	SNP	C	C	A			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr8:53853025C>A	uc011ldu.1	+	1	558	c.558C>A	c.(556-558)CGC>CGA	p.R186R		NM_005285	NP_005276	P48145	NPBW1_HUMAN	G protein-coupled receptor 7	186	Extracellular (Potential).				synaptic transmission	plasma membrane	opioid receptor activity|protein binding			ovary(2)|breast(1)	3		Lung NSC(129;0.0222)|all_epithelial(80;0.0301)|all_lung(136;0.0431)				AGGGCCGGCGCCAGTGCGTGC	0.706			NA											4	14					0.00909568	0.00960854	0.009096	1	0
NCOA2	10499	broad.mit.edu	37	8	71068967	71068967	+	Missense_Mutation	SNP	C	C	A			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr8:71068967C>A	uc003xyn.1	-	11	1795	c.1633G>T	c.(1633-1635)GGG>TGG	p.G545W		NM_006540	NP_006531	Q15596	NCOA2_HUMAN	nuclear receptor coactivator 2	545					cellular lipid metabolic process|transcription, DNA-dependent	nucleoplasm	histone acetyltransferase activity|ligand-dependent nuclear receptor binding|nuclear hormone receptor binding|signal transducer activity		PAX3/NCOA2(4)	lung(6)|soft_tissue(4)|breast(2)|skin(2)|ovary(1)|pancreas(1)	16	Breast(64;0.201)		Epithelial(68;0.0147)|OV - Ovarian serous cystadenocarcinoma(28;0.0455)|all cancers(69;0.0606)			AATGAGACCCCGTGCCCCTCG	0.512			NA	T	RUNXBP2	AML								16	93					2.23348e-06	2.77877e-06	0.004007	1	0
CALB1	793	broad.mit.edu	37	8	91075512	91075512	+	Missense_Mutation	SNP	G	G	C			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr8:91075512G>C	uc003yel.1	-	8	725	c.543C>G	c.(541-543)TTC>TTG	p.F181L	CALB1_uc011lge.1_Missense_Mutation_p.F124L	NM_004929	NP_004920	P05937	CALB1_HUMAN	calbindin 1	181						nucleus	calcium ion binding|vitamin D binding			pancreas(1)	1			BRCA - Breast invasive adenocarcinoma(11;0.00953)			TAAGTACCTGGAATTTAAGAA	0.284	Melanoma(46;573 1182 27367 39727 48386)		NA											5	19					0	0	0.000602	0	0
CDH17	1015	broad.mit.edu	37	8	95178176	95178176	+	Missense_Mutation	SNP	A	A	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr8:95178176A>T	uc003ygh.2	-	10	1220	c.1095T>A	c.(1093-1095)CAT>CAA	p.H365Q	CDH17_uc011lgo.1_Missense_Mutation_p.H151Q|CDH17_uc011lgp.1_Missense_Mutation_p.H365Q	NM_004063	NP_004054	Q12864	CAD17_HUMAN	cadherin 17 precursor	365	Extracellular (Potential).|Cadherin 4.					integral to membrane	calcium ion binding			ovary(5)|skin(1)	6	Breast(36;4.65e-06)		BRCA - Breast invasive adenocarcinoma(8;0.00691)			CATCCCTGTCATGTGCAGTAA	0.408			NA											10	38					0	0	0.010729	0	0
VPS13B	157680	broad.mit.edu	37	8	100844858	100844858	+	Missense_Mutation	SNP	C	C	T	rs149842139	byFrequency	TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr8:100844858C>T	uc003yiv.2	+	52	9778	c.9667C>T	c.(9667-9669)CGG>TGG	p.R3223W	VPS13B_uc003yiw.2_Missense_Mutation_p.R3198W	NM_017890	NP_060360	Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13B isoform 5	3223					protein transport					ovary(7)|skin(4)|lung(3)|central_nervous_system(2)|pancreas(2)|breast(1)|kidney(1)	20	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			CGGGAATTTCCGGGAAAATGG	0.468	Colon(161;2205 2542 7338 31318)		NA											18	64					0	0	0.00499	0	0
RIMS2	9699	broad.mit.edu	37	8	105257206	105257206	+	Nonsense_Mutation	SNP	G	G	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr8:105257206G>T	uc003yls.2	+	24	3692	c.3451G>T	c.(3451-3453)GAA>TAA	p.E1151*	RIMS2_uc003ylp.2_Nonsense_Mutation_p.E1133*|RIMS2_uc003ylw.2_Nonsense_Mutation_p.E1140*|RIMS2_uc003ylq.2_Nonsense_Mutation_p.E947*|RIMS2_uc003ylr.2_Nonsense_Mutation_p.E972*	NM_014677	NP_055492	Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	1195					intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			ovary(6)|lung(2)|breast(2)|skin(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	15			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			CCTGGCCGTGGAAATGAGGAA	0.463			NA								HNSCC(12;0.0054)			33	127					1.99505e-19	3.65186e-19	0.012213	1	0
TM7SF4	81501	broad.mit.edu	37	8	105361085	105361085	+	Missense_Mutation	SNP	G	G	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr8:105361085G>T	uc003ylx.1	+	2	354	c.305G>T	c.(304-306)GGC>GTC	p.G102V		NM_030788	NP_110415	Q9H295	TM7S4_HUMAN	dendritic cell-specific transmembrane protein	102	Helical; (Potential).				osteoclast differentiation	cell surface|integral to membrane|plasma membrane				pancreas(2)|large_intestine(1)|ovary(1)	4			OV - Ovarian serous cystadenocarcinoma(57;1.61e-06)|STAD - Stomach adenocarcinoma(118;0.229)			ATTGCAGCTGGCACAGGGATC	0.448			NA											13	56					2.68362e-12	4.2524e-12	0.013537	1	0
CSMD3	114788	broad.mit.edu	37	8	113402960	113402960	+	Missense_Mutation	SNP	G	G	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr8:113402960G>T	uc003ynu.2	-	36	6026	c.5867C>A	c.(5866-5868)CCT>CAT	p.P1956H	CSMD3_uc003yns.2_Missense_Mutation_p.P1158H|CSMD3_uc003ynt.2_Missense_Mutation_p.P1916H|CSMD3_uc011lhx.1_Missense_Mutation_p.P1852H	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	1956	Extracellular (Potential).|CUB 11.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						ATAAGGCTCAGGGTATCCAGG	0.403			NA								HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			14	36					6.81908e-15	1.14914e-14	0.00245	1	0
CSMD3	114788	broad.mit.edu	37	8	113697783	113697783	+	Missense_Mutation	SNP	T	T	A			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr8:113697783T>A	uc003ynu.2	-	15	2493	c.2334A>T	c.(2332-2334)AAA>AAT	p.K778N	CSMD3_uc003yns.2_Missense_Mutation_p.K50N|CSMD3_uc003ynt.2_Missense_Mutation_p.K738N|CSMD3_uc011lhx.1_Missense_Mutation_p.K674N	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	778	Extracellular (Potential).|CUB 4.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						AGTCACCATCTTTAACAGCAA	0.433			NA								HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			21	71					0	0	0.010504	0	0
TG	7038	broad.mit.edu	37	8	133935738	133935738	+	Missense_Mutation	SNP	G	G	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr8:133935738G>T	uc003ytw.2	+	22	4725	c.4684G>T	c.(4684-4686)GAC>TAC	p.D1562Y	TG_uc010mdw.2_Missense_Mutation_p.D321Y|TG_uc011ljb.1_5'UTR|TG_uc003ytx.1_Intron	NM_003235	NP_003226	P01266	THYG_HUMAN	thyroglobulin precursor	1562	Thyroglobulin type-1 11.				hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			ovary(8)|breast(4)|pancreas(1)|central_nervous_system(1)|skin(1)	15	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		CCCTCTTGAGGACTCACAGTG	0.582			NA											13	42					4.36969e-10	6.41358e-10	0.001855	1	0
FAM135B	51059	broad.mit.edu	37	8	139144923	139144923	+	Silent	SNP	G	G	A			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr8:139144923G>A	uc003yuy.2	-	20	4305	c.4134C>T	c.(4132-4134)ATC>ATT	p.I1378I	FAM135B_uc003yux.2_Silent_p.I1279I|FAM135B_uc003yuz.2_RNA	NM_015912	NP_056996	Q49AJ0	F135B_HUMAN	hypothetical protein LOC51059	1378										ovary(7)|skin(2)	9	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			CGGCTCGGCCGATCAGGGTGT	0.537			NA								HNSCC(54;0.14)			53	239					0	0	0.01441	0	0
CYP11B2	1585	broad.mit.edu	37	8	143994787	143994787	+	Silent	SNP	C	C	G			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr8:143994787C>G	uc003yxk.1	-	6	1038	c.1035G>C	c.(1033-1035)CTG>CTC	p.L345L		NM_000498	NP_000489	P19099	C11B2_HUMAN	cytochrome P450, family 11, subfamily B,	345					aldosterone biosynthetic process|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|potassium ion homeostasis|regulation of blood volume by renal aldosterone|sodium ion homeostasis|xenobiotic metabolic process		corticosterone 18-monooxygenase activity|electron carrier activity|steroid 11-beta-monooxygenase activity				0	all_cancers(97;5.56e-11)|all_epithelial(106;2.49e-08)|Lung NSC(106;0.000228)|all_lung(105;0.000633)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)				Candesartan(DB00796)|Metyrapone(DB01011)	CTGCGGCGGCCAGGCTCTCCT	0.637			NA							Familial_Hyperaldosteronism_type_I				26	121					0	0	0.004656	0	0
ZNF34	80778	broad.mit.edu	37	8	145999678	145999678	+	Missense_Mutation	SNP	G	G	A			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr8:145999678G>A	uc003zdy.3	-	6	758	c.656C>T	c.(655-657)TCA>TTA	p.S219L	ZNF34_uc010mgb.2_Missense_Mutation_p.S116L|ZNF34_uc003zdx.3_Missense_Mutation_p.S198L	NM_030580	NP_085057	Q8IZ26	ZNF34_HUMAN	zinc finger protein 34	219					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_cancers(97;3.54e-11)|all_epithelial(106;2.65e-10)|Lung NSC(106;4.08e-05)|all_lung(105;0.000125)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)	Acute lymphoblastic leukemia(644;0.221)	OV - Ovarian serous cystadenocarcinoma(54;2.75e-39)|Epithelial(56;5.18e-38)|all cancers(56;4.41e-33)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.11)	GBM - Glioblastoma multiforme(99;0.0179)		TGTTTTTTTTGACCTGTGTAC	0.358			NA											8	30					0	0	0.00308	0	0
RANBP6	26953	broad.mit.edu	37	9	6015050	6015050	+	Silent	SNP	G	G	A			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr9:6015050G>A	uc003zjr.2	-	1	569	c.558C>T	c.(556-558)GAC>GAT	p.D186D	RANBP6_uc011lmf.1_Intron|RANBP6_uc003zjs.2_Intron	NM_012416	NP_036548	O60518	RNBP6_HUMAN	RAN binding protein 6	186					protein transport	cytoplasm|nucleus	binding			ovary(3)	3		Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.00522)|Lung(218;0.101)		GAATACACTGGTCCAACAACC	0.428			NA											14	51					0	0	0.001855	0	0
PTPRD	5789	broad.mit.edu	37	9	8492961	8492961	+	Missense_Mutation	SNP	G	G	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr9:8492961G>T	uc003zkk.2	-	26	3079	c.2368C>A	c.(2368-2370)CTC>ATC	p.L790I	PTPRD_uc003zkp.2_Intron|PTPRD_uc003zkq.2_Intron|PTPRD_uc003zkr.2_Intron|PTPRD_uc003zks.2_Intron|PTPRD_uc003zkl.2_Missense_Mutation_p.L781I|PTPRD_uc003zkm.2_Missense_Mutation_p.L777I|PTPRD_uc003zkn.2_Intron|PTPRD_uc003zko.2_Intron	NM_002839	NP_002830	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	790	Fibronectin type-III 5.|Extracellular (Potential).				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			lung(14)|large_intestine(3)|ovary(2)|breast(2)|urinary_tract(1)	22		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		TCAGGCTGGAGCCCAGAAATG	0.498			NA								TSP Lung(15;0.13)			22	87					1.87028e-06	2.35915e-06	0.012319	1	0
ELAVL2	1993	broad.mit.edu	37	9	23701398	23701398	+	Missense_Mutation	SNP	G	G	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr9:23701398G>T	uc003zpu.2	-	5	967	c.692C>A	c.(691-693)GCT>GAT	p.A231D	ELAVL2_uc003zps.2_Missense_Mutation_p.A231D|ELAVL2_uc003zpt.2_Missense_Mutation_p.A231D|ELAVL2_uc003zpv.2_Missense_Mutation_p.A231D|ELAVL2_uc003zpw.2_Missense_Mutation_p.A231D	NM_004432	NP_004423	Q12926	ELAV2_HUMAN	ELAV (embryonic lethal, abnormal vision,	231					regulation of transcription, DNA-dependent		mRNA 3'-UTR binding|nucleotide binding|protein binding			ovary(2)|central_nervous_system(1)	3				GBM - Glioblastoma multiforme(1;2.18e-156)|Lung(42;2.15e-28)|LUSC - Lung squamous cell carcinoma(38;1.02e-19)		TGCCTGCTGAGCTAGCGGTCC	0.443			NA											49	203					9.57592e-29	1.81543e-28	0.01441	1	0
ROR2	4920	broad.mit.edu	37	9	94486708	94486708	+	Missense_Mutation	SNP	G	G	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr9:94486708G>T	uc004arj.1	-	9	2267	c.2068C>A	c.(2068-2070)CTG>ATG	p.L690M	ROR2_uc004ari.1_Missense_Mutation_p.L550M	NM_004560	NP_004551	Q01974	ROR2_HUMAN	receptor tyrosine kinase-like orphan receptor 2	690	Cytoplasmic (Potential).|Protein kinase.				negative regulation of cell proliferation|positive regulation of cell migration|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity|Wnt-protein binding			lung(8)|central_nervous_system(5)|ovary(3)|large_intestine(2)|stomach(1)|breast(1)	20						TAGGGCTGCAGGCCGTAGCTG	0.617			NA											20	46					5.03518e-11	7.67323e-11	0.007413	1	0
COL15A1	1306	broad.mit.edu	37	9	101810113	101810113	+	Missense_Mutation	SNP	G	G	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr9:101810113G>T	uc004azb.1	+	27	2931	c.2725G>T	c.(2725-2727)GGG>TGG	p.G909W		NM_001855	NP_001846	P39059	COFA1_HUMAN	alpha 1 type XV collagen precursor	909	Triple-helical region 5 (COL5).				angiogenesis|cell differentiation|signal transduction	collagen type XV|extracellular space|integral to membrane	binding			ovary(6)	6		Acute lymphoblastic leukemia(62;0.0562)				TGGCCTTCCCGGGCGACCTGT	0.542			NA											66	123					1.92745e-42	3.70932e-42	0.01441	1	0
OR1J4	26219	broad.mit.edu	37	9	125281713	125281713	+	Silent	SNP	A	A	G			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr9:125281713A>G	uc011lyw.1	+	1	294	c.294A>G	c.(292-294)GTA>GTG	p.V98V		NM_001004452	NP_001004452	Q8NGS1	OR1J4_HUMAN	olfactory receptor, family 1, subfamily J,	98	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						CAGGGTGTGTAACTCAGATGT	0.423			NA											55	120					0	0	0.01441	0	0
NR5A1	2516	broad.mit.edu	37	9	127255381	127255381	+	Silent	SNP	C	C	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr9:127255381C>T	uc004boo.1	-	5	1105	c.918G>A	c.(916-918)CTG>CTA	p.L306L		NM_004959	NP_004950	Q13285	STF1_HUMAN	nuclear receptor subfamily 5, group A, member 1	306	Important for dimerization.|Ligand-binding.				cell-cell signaling|male gonad development|positive regulation of transcription from RNA polymerase II promoter|primary sex determination|regulation of steroid biosynthetic process|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	enzyme binding|phospholipid binding|steroid hormone receptor activity|transcription coactivator activity|zinc ion binding				0						GGTCGAACACCAGCAGCTCGC	0.692			NA											14	20					0	0	0.001855	0	0
COL5A1	1289	broad.mit.edu	37	9	137676928	137676928	+	Missense_Mutation	SNP	C	C	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr9:137676928C>T	uc004cfe.2	+	30	2960	c.2578C>T	c.(2578-2580)CCC>TCC	p.P860S		NM_000093	NP_000084	P20908	CO5A1_HUMAN	alpha 1 type V collagen preproprotein	860	Triple-helical region.				axon guidance|cell adhesion|collagen biosynthetic process|collagen fibril organization|eye morphogenesis|fibril organization|integrin biosynthetic process|skin development|wound healing, spreading of epidermal cells	collagen type V	heparin binding|integrin binding|platelet-derived growth factor binding|proteoglycan binding			skin(4)|ovary(3)|pancreas(2)|central_nervous_system(1)|kidney(1)	11		Myeloproliferative disorder(178;0.0341)		all cancers(34;2.28e-08)|OV - Ovarian serous cystadenocarcinoma(145;6.03e-08)|Epithelial(140;6.4e-08)|GBM - Glioblastoma multiforme(294;0.131)		TCCTCTGGGACCCCCTGGGGA	0.657			NA											4	44					0	0	0.009096	0	0
CACNA1B	774	broad.mit.edu	37	9	140991002	140991002	+	Missense_Mutation	SNP	C	C	A			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr9:140991002C>A	uc004cog.2	+	36	5306	c.5161C>A	c.(5161-5163)CTA>ATA	p.L1721I	CACNA1B_uc004coi.2_Missense_Mutation_p.L933I|CACNA1B_uc004cok.1_RNA|CACNA1B_uc010ncp.1_Intron	NM_000718	NP_000709	Q00975	CAC1B_HUMAN	calcium channel, voltage-dependent, N type,	1721	Cytoplasmic (Potential).				membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	ATP binding|protein C-terminus binding|voltage-gated calcium channel activity			breast(3)|large_intestine(2)|ovary(1)	6	all_cancers(76;0.166)			OV - Ovarian serous cystadenocarcinoma(145;1.16e-05)|Epithelial(140;0.000476)	Amlodipine(DB00381)|Gabapentin(DB00996)	CTCTTCCATCCTAGGTCCTCA	0.557			NA											26	58					3.28513e-13	5.33833e-13	0.003954	1	0
ARSF	416	broad.mit.edu	37	X	3002504	3002504	+	Missense_Mutation	SNP	C	C	A			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chrX:3002504C>A	uc004cre.1	+	6	848	c.627C>A	c.(625-627)AGC>AGA	p.S209R	ARSF_uc004crf.1_Missense_Mutation_p.S209R	NM_004042	NP_004033	P54793	ARSF_HUMAN	arylsulfatase F precursor	209						extracellular region	arylsulfatase activity|metal ion binding			ovary(2)	2		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				GGAAGCTGAGCGGCTGGGTCT	0.517			NA											13	101					9.31168e-06	1.11705e-05	0.001855	1	0
MXRA5	25878	broad.mit.edu	37	X	3229391	3229391	+	Missense_Mutation	SNP	C	C	A			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chrX:3229391C>A	uc004crg.3	-	7	7010	c.6853G>T	c.(6853-6855)GTG>TTG	p.V2285L		NM_015419	NP_056234	Q9NR99	MXRA5_HUMAN	adlican precursor	2285	Ig-like C2-type 7.					extracellular region				ovary(5)|lung(1)|central_nervous_system(1)|skin(1)	8		all_lung(23;0.00031)|Lung NSC(23;0.000946)				AAGGAGTTCACCAGACTCCCG	0.567			NA											21	112					1.01871e-10	1.53409e-10	0.008871	1	0
MXRA5	25878	broad.mit.edu	37	X	3239278	3239278	+	Missense_Mutation	SNP	G	G	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chrX:3239278G>T	uc004crg.3	-	5	4605	c.4448C>A	c.(4447-4449)CCT>CAT	p.P1483H		NM_015419	NP_056234	Q9NR99	MXRA5_HUMAN	adlican precursor	1483						extracellular region				ovary(5)|lung(1)|central_nervous_system(1)|skin(1)	8		all_lung(23;0.00031)|Lung NSC(23;0.000946)				GGCAGCAGTAGGGGTGTGATT	0.512			NA											17	66					1.15088e-07	1.5337e-07	0.004007	1	0
NLGN4X	57502	broad.mit.edu	37	X	6069174	6069174	+	Missense_Mutation	SNP	G	G	C			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chrX:6069174G>C	uc010ndh.2	-	2	835	c.334C>G	c.(334-336)CAG>GAG	p.Q112E	NLGN4X_uc004crp.2_Missense_Mutation_p.Q112E|NLGN4X_uc004crq.2_Missense_Mutation_p.Q112E|NLGN4X_uc010ndi.2_Missense_Mutation_p.Q112E|NLGN4X_uc004crr.2_Missense_Mutation_p.Q112E|NLGN4X_uc010ndj.2_Missense_Mutation_p.Q112E	NM_181332	NP_851849	Q8N0W4	NLGNX_HUMAN	X-linked neuroligin 4 precursor	112	Extracellular (Potential).				brainstem development|cell adhesion|cell-cell junction organization|cerebellum development|male courtship behavior|positive regulation of organ growth|regulation of excitatory postsynaptic membrane potential|social behavior|synapse assembly|territorial aggressive behavior|vocalization behavior	cell surface|dendrite|integral to plasma membrane|synapse	chloride ion binding|neurexin binding|protein homodimerization activity|receptor activity			skin(2)|large_intestine(1)|ovary(1)	4						TCCAGGTGCTGGGGGCACACA	0.527			NA											25	106					0	0	0.003954	0	0
WWC3	55841	broad.mit.edu	37	X	10035347	10035347	+	Missense_Mutation	SNP	C	C	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chrX:10035347C>T	uc004csx.3	+	3	235	c.37C>T	c.(37-39)CCA>TCA	p.P13S	WWC3_uc010nds.2_5'UTR	NM_015691	NP_056506	Q9ULE0	WWC3_HUMAN	WWC family member 3	13										ovary(4)	4						GATTGAGGATCCAAGAGAACA	0.388			NA											4	20					0	0	0.009096	0	0
WWC3	55841	broad.mit.edu	37	X	10096748	10096748	+	Missense_Mutation	SNP	G	G	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chrX:10096748G>T	uc004csx.3	+	17	2630	c.2432G>T	c.(2431-2433)CGG>CTG	p.R811L	WWC3_uc010nds.2_Missense_Mutation_p.R475L|WWC3_uc010ndt.2_RNA	NM_015691	NP_056506	Q9ULE0	WWC3_HUMAN	WWC family member 3	811	Potential.									ovary(4)	4						ATATCCGAGCGGTAAGGGCTA	0.647			NA											10	23					1.58986e-06	2.01341e-06	0.008291	1	0
FANCB	2187	broad.mit.edu	37	X	14861873	14861873	+	Missense_Mutation	SNP	G	G	A			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chrX:14861873G>A	uc004cwg.1	-	10	2664	c.2396C>T	c.(2395-2397)GCG>GTG	p.A799V	FANCB_uc004cwh.1_Missense_Mutation_p.A799V	NM_001018113	NP_001018123	Q8NB91	FANCB_HUMAN	Fanconi anemia complementation group B	799					DNA repair	nucleoplasm				lung(1)	1	Hepatocellular(33;0.183)					TAAAGCAGCCGCGACGACACT	0.408			NA						Involved_in_tolerance_or_repair_of_DNA_crosslinks	FanconAnemia				26	85					0	0	0.00632	0	0
ASB11	140456	broad.mit.edu	37	X	15306042	15306042	+	Missense_Mutation	SNP	G	G	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chrX:15306042G>T	uc004cwp.1	-	6	808	c.808C>A	c.(808-810)CCA>ACA	p.P270T	ASB11_uc004cwo.1_Missense_Mutation_p.P249T|ASB11_uc010nes.1_RNA|ASB11_uc010net.1_Missense_Mutation_p.P253T	NM_080873	NP_543149	Q8WXH4	ASB11_HUMAN	ankyrin repeat and SOCS box-containing protein	270					intracellular signal transduction					breast(2)|skin(1)	3	Hepatocellular(33;0.183)					CTGCTTTTTGGAGCCGCCAGA	0.537			NA											15	76					6.72482e-11	1.01751e-10	0.003163	1	0
ACE2	59272	broad.mit.edu	37	X	15618935	15618935	+	Missense_Mutation	SNP	G	G	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chrX:15618935G>T	uc004cxa.1	-	1	268	c.100C>A	c.(100-102)CAC>AAC	p.H34N	ACE2_uc004cxb.2_Missense_Mutation_p.H34N	NM_021804	NP_068576	Q9BYF1	ACE2_HUMAN	angiotensin I converting enzyme 2 precursor	34	Extracellular (Potential).|Interaction with SARS-CoV spike glycoprotein.				angiotensin-mediated drinking behavior|proteolysis|receptor biosynthetic process|regulation of cell proliferation|virion attachment, binding of host cell surface receptor	cell surface|extracellular space|integral to membrane|membrane raft|plasma membrane	carboxypeptidase activity|glycoprotein binding|metallopeptidase activity|peptidyl-dipeptidase activity|viral receptor activity|zinc ion binding			ovary(3)	3	Hepatocellular(33;0.183)				Moexipril(DB00691)	TCGGCTTCGTGGTTAAACTTG	0.438			NA											15	92					1.05317e-09	1.53167e-09	0.00245	1	0
GRPR	2925	broad.mit.edu	37	X	16168473	16168473	+	Silent	SNP	C	C	A			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chrX:16168473C>A	uc004cxj.2	+	2	1112	c.459C>A	c.(457-459)GCC>GCA	p.A153A		NM_005314	NP_005305	P30550	GRPR_HUMAN	gastrin-releasing peptide receptor	153	Helical; Name=4; (Potential).				cell proliferation	integral to plasma membrane	bombesin receptor activity			ovary(3)|lung(1)	4	Hepatocellular(33;0.183)					CCTCTCATGCCCTGATGAAGA	0.488			NA											21	99					2.27731e-05	2.66662e-05	0.012319	1	0
REPS2	9185	broad.mit.edu	37	X	17047678	17047678	+	Missense_Mutation	SNP	C	C	A			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chrX:17047678C>A	uc004cxv.1	+	5	874	c.703C>A	c.(703-705)CAG>AAG	p.Q235K	REPS2_uc004cxw.1_Missense_Mutation_p.Q234K|REPS2_uc011miw.1_Missense_Mutation_p.Q94K	NM_004726	NP_004717	Q8NFH8	REPS2_HUMAN	RALBP1 associated Eps domain containing 2	235					epidermal growth factor receptor signaling pathway|protein complex assembly	cytoplasm	calcium ion binding|protein binding			skin(2)|central_nervous_system(1)	3	Hepatocellular(33;0.183)					GCCCCTTGTCCAGCCCGAGGG	0.498			NA											13	82					7.93312e-07	1.01678e-06	0.00245	1	0
CXorf23	256643	broad.mit.edu	37	X	19984254	19984254	+	Silent	SNP	G	G	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chrX:19984254G>T	uc004czp.2	-	2	555	c.555C>A	c.(553-555)TCC>TCA	p.S185S	CXorf23_uc010nfn.2_5'Flank|CXorf23_uc011mjg.1_5'Flank|CXorf23_uc004czo.2_Silent_p.S135S	NM_198279	NP_938020	A2AJT9	CX023_HUMAN	hypothetical protein LOC256643	185						mitochondrion				lung(1)|skin(1)	2						TAGTTGACTGGGAGTATTTTT	0.408			NA											29	98					1.08312e-15	1.86472e-15	0.009535	1	0
YY2	404281	broad.mit.edu	37	X	21875099	21875099	+	Missense_Mutation	SNP	C	C	A			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chrX:21875099C>A	uc011mjp.1	+	1	497	c.497C>A	c.(496-498)ACG>AAG	p.T166K	MBTPS2_uc004dae.2_Intron|MBTPS2_uc010nfr.2_Intron|YY2_uc010nfq.2_Missense_Mutation_p.T384K|MBTPS2_uc004dab.2_Intron	NM_206923	NP_996806	O15391	TYY2_HUMAN	YY2 transcription factor	166					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|plasma membrane	DNA binding|zinc ion binding			breast(1)|skin(1)	2						AGCCTGGGCACGAGGAAGTGG	0.488			NA											32	119					2.08457e-15	3.57916e-15	0.010818	1	0
PDK3	5165	broad.mit.edu	37	X	24552145	24552145	+	Missense_Mutation	SNP	A	A	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chrX:24552145A>T	uc004dbg.2	+	11	1406	c.1177A>T	c.(1177-1179)AGC>TGC	p.S393C	PDK3_uc004dbh.2_Missense_Mutation_p.S393C	NM_005391	NP_005382	Q15120	PDK3_HUMAN	pyruvate dehydrogenase kinase 3 isoform 2	393					glucose metabolic process|peptidyl-histidine phosphorylation|pyruvate metabolic process|regulation of acetyl-CoA biosynthetic process from pyruvate	mitochondrial matrix	ATP binding|protein binding|pyruvate dehydrogenase (acetyl-transferring) kinase activity|two-component sensor activity			lung(4)|upper_aerodigestive_tract(1)|ovary(1)	6						GAGCAATCCCAGCAGTGAACC	0.428			NA											3	33					0	0	0.009096	0	0
MAGEB6	158809	broad.mit.edu	37	X	26212836	26212836	+	Silent	SNP	C	C	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chrX:26212836C>T	uc004dbr.2	+	2	1022	c.873C>T	c.(871-873)CTC>CTT	p.L291L	MAGEB6_uc010ngc.1_Silent_p.L71L	NM_173523	NP_775794	Q8N7X4	MAGB6_HUMAN	melanoma antigen family B, 6	291	MAGE.									ovary(3)	3						TGATGTCGCTCCTGGTTGTGA	0.542			NA											19	267					0	0	0.008871	0	0
NR0B1	190	broad.mit.edu	37	X	30326724	30326724	+	Missense_Mutation	SNP	C	C	A			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chrX:30326724C>A	uc004dcf.3	-	1	772	c.757G>T	c.(757-759)GTG>TTG	p.V253L		NM_000475	NP_000466	P51843	NR0B1_HUMAN	nuclear receptor subfamily 0, group B, member 1	253	4; truncated.|4 X 67 AA tandem repeats.				adrenal gland development|hypothalamus development|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of steroid hormone receptor signaling pathway|pituitary gland development|protein localization|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|steroid biosynthetic process	cytoplasm|membrane fraction|nucleoplasm|nucleus|polysomal ribosome	AF-2 domain binding|DNA hairpin binding|ligand-regulated transcription factor activity|protein domain specific binding|protein homodimerization activity|RNA binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|steroid hormone receptor binding|transcription corepressor activity|transcription factor binding			ovary(1)|lung(1)	2					Dexamethasone(DB01234)|Tretinoin(DB00755)	TCGCAGACCACCTGTGGACTC	0.677			NA									OREG0019719	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	7	26					0.00198382	0.00216386	0.001984	1	0
NR0B1	190	broad.mit.edu	37	X	30327329	30327329	+	Missense_Mutation	SNP	C	C	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chrX:30327329C>T	uc004dcf.3	-	1	167	c.152G>A	c.(151-153)AGA>AAA	p.R51K		NM_000475	NP_000466	P51843	NR0B1_HUMAN	nuclear receptor subfamily 0, group B, member 1	51	4 X 67 AA tandem repeats.|1.				adrenal gland development|hypothalamus development|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of steroid hormone receptor signaling pathway|pituitary gland development|protein localization|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|steroid biosynthetic process	cytoplasm|membrane fraction|nucleoplasm|nucleus|polysomal ribosome	AF-2 domain binding|DNA hairpin binding|ligand-regulated transcription factor activity|protein domain specific binding|protein homodimerization activity|RNA binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|steroid hormone receptor binding|transcription corepressor activity|transcription factor binding			ovary(1)|lung(1)	2					Dexamethasone(DB01234)|Tretinoin(DB00755)	CAGCCCCTCTCTGCCCACCCC	0.672			NA											7	43					0	0	0.004482	0	0
DMD	1756	broad.mit.edu	37	X	32466669	32466669	+	Silent	SNP	A	A	G			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chrX:32466669A>G	uc004dda.1	-	27	3934	c.3690T>C	c.(3688-3690)CCT>CCC	p.P1230P	DMD_uc004dcz.2_Silent_p.P1107P|DMD_uc004dcy.1_Silent_p.P1226P|DMD_uc004ddb.1_Silent_p.P1222P|DMD_uc010ngo.1_Intron	NM_004006	NP_003997	P11532	DMD_HUMAN	dystrophin Dp427m isoform	1230	Spectrin 8.				muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			ovary(3)|pancreas(2)|large_intestine(1)	6		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				CTTGTGCTACAGGTGGAGCTT	0.423			NA											4	65					0	0	0.009096	0	0
MAGEB16	139604	broad.mit.edu	37	X	35820687	35820687	+	Missense_Mutation	SNP	T	T	A			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chrX:35820687T>A	uc010ngt.1	+	2	653	c.374T>A	c.(373-375)CTG>CAG	p.L125Q		NM_001099921	NP_001093391	A2A368	MAGBG_HUMAN	melanoma antigen family B, 16	125	MAGE.									lung(3)|ovary(2)|breast(1)|skin(1)	7						AATTTCATGCTGCACAAGTGT	0.453			NA											11	47					0	0	0.010729	0	0
USP11	8237	broad.mit.edu	37	X	47107328	47107328	+	Nonstop_Mutation	SNP	G	G	C			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chrX:47107328G>C	uc004dhp.2	+	21	2891	c.2891G>C	c.(2890-2892)TGA>TCA	p.*964S	USP11_uc004dhq.2_Nonstop_Mutation_p.*690S	NM_004651	NP_004642	P51784	UBP11_HUMAN	ubiquitin specific peptidase 11	964					protein deubiquitination|ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(1)|lung(1)|central_nervous_system(1)	3						GATGTTAATTGAGAGCCCTGG	0.597			NA											4	19					0	0	0.009096	0	0
GRIPAP1	56850	broad.mit.edu	37	X	48831665	48831665	+	Missense_Mutation	SNP	C	C	A			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chrX:48831665C>A	uc004dly.1	-	25	2370	c.2335G>T	c.(2335-2337)GAC>TAC	p.D779Y		NM_020137	NP_064522	Q4V328	GRAP1_HUMAN	GRIP1 associated protein 1 isoform 1	779						early endosome				breast(2)|kidney(1)	3						TTCACTAGGTCTCTCAGGACG	0.572			NA											6	44					0.00198382	0.00216386	0.001984	1	0
CCNB3	85417	broad.mit.edu	37	X	50053979	50053979	+	Missense_Mutation	SNP	C	C	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chrX:50053979C>T	uc004dox.3	+	6	3108	c.2810C>T	c.(2809-2811)CCC>CTC	p.P937L	CCNB3_uc004doy.2_Missense_Mutation_p.P937L|CCNB3_uc004doz.2_Intron|CCNB3_uc010njq.2_Intron	NM_033031	NP_149020	Q8WWL7	CCNB3_HUMAN	cyclin B3 isoform 3	937					cell division|meiosis|regulation of cyclin-dependent protein kinase activity|regulation of G2/M transition of mitotic cell cycle	nucleus	protein kinase binding			ovary(4)|lung(3)|large_intestine(1)|pancreas(1)	9	Ovarian(276;0.236)					AATGAGAAACCCACCACTGGG	0.453			NA											14	92					0	0	0.003163	0	0
DGKK	139189	broad.mit.edu	37	X	50163469	50163469	+	Missense_Mutation	SNP	G	G	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chrX:50163469G>T	uc010njr.1	-	4	934	c.874C>A	c.(874-876)CCC>ACC	p.P292T		NM_001013742	NP_001013764	Q5KSL6	DGKK_HUMAN	diacylglycerol kinase kappa	292	PH.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|diacylglycerol metabolic process|intracellular signal transduction|platelet activation|response to oxidative stress	cytoplasm|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			ovary(1)|kidney(1)	2	Ovarian(276;0.236)					TTCCGGTTGGGTGCAGCCAGA	0.393			NA											19	106					1.00905e-13	1.65235e-13	0.008871	1	0
SHROOM4	57477	broad.mit.edu	37	X	50377606	50377606	+	Missense_Mutation	SNP	G	G	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chrX:50377606G>T	uc004dpe.2	-	4	1493	c.1467C>A	c.(1465-1467)CAC>CAA	p.H489Q	SHROOM4_uc004dpd.3_RNA|SHROOM4_uc004dpf.1_Missense_Mutation_p.H373Q	NM_020717	NP_065768	Q9ULL8	SHRM4_HUMAN	shroom family member 4	489					actin filament organization|brain development|cell morphogenesis|cognition	apical plasma membrane|basal plasma membrane|internal side of plasma membrane|nucleus	actin filament binding			upper_aerodigestive_tract(1)	1	Ovarian(276;0.236)					TTTGGCTCTGGTGTCCCAAAA	0.517			NA											17	120					9.16793e-09	1.29777e-08	0.00499	1	0
WNK3	65267	broad.mit.edu	37	X	54275959	54275959	+	Missense_Mutation	SNP	A	A	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chrX:54275959A>T	uc004dtd.1	-	17	3261	c.2822T>A	c.(2821-2823)GTG>GAG	p.V941E	WNK3_uc004dtc.1_Missense_Mutation_p.V941E	NM_001002838	NP_001002838	Q9BYP7	WNK3_HUMAN	WNK lysine deficient protein kinase 3 isoform 2	941					intracellular protein kinase cascade|positive regulation of establishment of protein localization in plasma membrane|positive regulation of peptidyl-threonine phosphorylation|positive regulation of rubidium ion transmembrane transporter activity|positive regulation of rubidium ion transport|positive regulation of sodium ion transmembrane transporter activity|positive regulation of sodium ion transport|protein autophosphorylation	adherens junction|tight junction	ATP binding|protein binding|protein serine/threonine kinase activity|rubidium ion transmembrane transporter activity|sodium ion transmembrane transporter activity			lung(4)|ovary(3)|kidney(2)|central_nervous_system(2)	11						ACCATCAACCACATCCTTGTG	0.403			NA											29	118					0	0	0.00632	0	0
ITIH5L	347365	broad.mit.edu	37	X	54783638	54783638	+	Missense_Mutation	SNP	G	G	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chrX:54783638G>T	uc004dtj.2	-	8	2899	c.2869C>A	c.(2869-2871)CTG>ATG	p.L957M		NM_198510	NP_940912	Q6UXX5	ITH5L_HUMAN	inter-alpha (globulin) inhibitor H5-like	957	Pro-rich.				hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			lung(2)|skin(2)|ovary(1)|breast(1)	6						GATGGTCCCAGAACTTGCCTG	0.587			NA											19	64					6.94344e-10	1.01212e-09	0.006122	1	0
ZXDA	7789	broad.mit.edu	37	X	57936015	57936015	+	Missense_Mutation	SNP	C	C	A			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chrX:57936015C>A	uc004dve.2	-	1	1053	c.840G>T	c.(838-840)AAG>AAT	p.K280N		NM_007156	NP_009087	P98168	ZXDA_HUMAN	zinc finger, X-linked, duplicated A	280	C2H2-type 1.|Required for interaction with ZXDC.				positive regulation of transcription, DNA-dependent	nucleus	C2H2 zinc finger domain binding|identical protein binding|nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1						GCTGGTGCTTCTTGGCGAAGG	0.692			NA											5	24					0.000602214	0.000674184	0.000602	1	0
FAM123B	139285	broad.mit.edu	37	X	63411755	63411755	+	Missense_Mutation	SNP	T	T	C			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chrX:63411755T>C	uc004dvo.2	-	2	1685	c.1412A>G	c.(1411-1413)TAT>TGT	p.Y471C		NM_152424	NP_689637	Q5JTC6	F123B_HUMAN	family with sequence similarity 123B	471					Wnt receptor signaling pathway	cytoplasm|nucleus|plasma membrane		p.0?(40)		kidney(99)|large_intestine(6)|ovary(3)|lung(2)|breast(1)|liver(1)	112						GGAGTCATAATAACCTTCATC	0.542			NA											12	57					0	0	0.010729	0	0
STARD8	9754	broad.mit.edu	37	X	67943859	67943859	+	Silent	SNP	G	G	A			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chrX:67943859G>A	uc004dxa.2	+	13	3222	c.2850G>A	c.(2848-2850)GTG>GTA	p.V950V	STARD8_uc004dxb.2_Silent_p.V1030V|STARD8_uc004dxc.3_Silent_p.V950V	NM_014725	NP_055540	Q92502	STAR8_HUMAN	StAR-related lipid transfer (START) domain	950	START.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|focal adhesion	GTPase activator activity			breast(3)|ovary(2)|pancreas(1)	6						AACAACCTGTGCCAGAGTCGG	0.627			NA											11	66					0	0	0.010729	0	0
FAM155B	27112	broad.mit.edu	37	X	68749663	68749663	+	Missense_Mutation	SNP	C	C	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chrX:68749663C>T	uc004dxk.2	+	3	1331	c.1283C>T	c.(1282-1284)CCT>CTT	p.P428L		NM_015686	NP_056501	O75949	F155B_HUMAN	transmembrane protein 28	429						integral to membrane				ovary(1)|breast(1)	2						CGCCTCAGCCCTAGCAGGATC	0.547			NA											18	65					0	0	0.006122	0	0
SLC7A3	84889	broad.mit.edu	37	X	70145939	70145939	+	Missense_Mutation	SNP	A	A	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chrX:70145939A>T	uc004dyn.2	-	11	1868	c.1710T>A	c.(1708-1710)TTT>TTA	p.F570L	SLC7A3_uc004dyo.2_Missense_Mutation_p.F570L	NM_032803	NP_116192	Q8WY07	CTR3_HUMAN	solute carrier family 7 (cationic amino acid	570	Helical; Name=14; (Potential).				cellular nitrogen compound metabolic process	integral to membrane|plasma membrane				ovary(1)|kidney(1)	2	Renal(35;0.156)				L-Arginine(DB00125)|L-Lysine(DB00123)|L-Ornithine(DB00129)	TCCAGACCCCAAATCGGGCCC	0.488			NA											12	43					0	0	0.010729	0	0
RGAG4	340526	broad.mit.edu	37	X	71351284	71351284	+	Missense_Mutation	SNP	A	A	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chrX:71351284A>T	uc010nlh.1	-	1	468	c.107T>A	c.(106-108)CTC>CAC	p.L36H	NHSL2_uc011mqa.1_Intron|RGAG4_uc004eaj.1_RNA|NHSL2_uc004eak.1_5'Flank|NHSL2_uc010nli.2_5'Flank	NM_001024455	NP_001019626	Q5HYW3	RGAG4_HUMAN	retrotransposon gag domain containing 4	36										ovary(2)|skin(1)	3	Renal(35;0.156)					GGCTCTCCCGAGCTGGAGGCC	0.592			NA											14	94					0	0	0.001855	0	0
ZDHHC15	158866	broad.mit.edu	37	X	74670759	74670759	+	Splice_Site	SNP	T	T	A			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chrX:74670759T>A	uc004ecg.2	-	4	737	c.259_splice	c.e4-1	p.F87_splice	ZDHHC15_uc004ech.2_Splice_Site_p.F78_splice|ZDHHC15_uc011mqo.1_Splice_Site|ZDHHC15_uc004eci.2_Intron	NM_144969	NP_659406	Q96MV8	ZDH15_HUMAN	zinc finger, DHHC-type containing 15 isoform 1							integral to membrane	zinc ion binding			ovary(2)	2						CAAGTGGAACTGGAAGCAGGA	0.368			NA											12	36					0	0	0.013537	0	0
MAGEE2	139599	broad.mit.edu	37	X	75004218	75004218	+	Silent	SNP	C	C	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chrX:75004218C>T	uc004ecj.1	-	1	854	c.669G>A	c.(667-669)AGG>AGA	p.R223R		NM_138703	NP_619648	Q8TD90	MAGE2_HUMAN	melanoma antigen family E, 2	223	MAGE 1.									ovary(1)|skin(1)	2						TGAGGAGGTTCCTTGTGTTCC	0.493			NA											24	51					0	0	0.00333	0	0
CXorf26	51260	broad.mit.edu	37	X	75395337	75395337	+	Silent	SNP	G	G	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chrX:75395337G>T	uc004ecl.1	+	4	389	c.186G>T	c.(184-186)CTG>CTT	p.L62L		NM_016500	NP_057584	Q9BVG4	CX026_HUMAN	hypothetical protein LOC51260	62											0						CACAGTTCCTGAAACTCACCA	0.408			NA											4	36					0.00909568	0.00960854	0.009096	1	0
ATRX	546	broad.mit.edu	37	X	76890137	76890137	+	Missense_Mutation	SNP	G	G	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chrX:76890137G>T	uc004ecp.3	-	17	4989	c.4757C>A	c.(4756-4758)CCA>CAA	p.P1586Q	ATRX_uc004ecq.3_Missense_Mutation_p.P1548Q|ATRX_uc004eco.3_Missense_Mutation_p.P1371Q	NM_000489	NP_000480	P46100	ATRX_HUMAN	transcriptional regulator ATRX isoform 1	1586	Helicase ATP-binding.				DNA methylation|DNA recombination|DNA repair|regulation of transcription, DNA-dependent	nuclear heterochromatin	ATP binding|chromo shadow domain binding|DNA binding|DNA helicase activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(14)|pancreas(12)|lung(1)|breast(1)|skin(1)|kidney(1)	30					Phosphatidylserine(DB00144)	TCCTGAACCTGGAGATTTCTT	0.368			NA	Mis|F|N		Pancreatic neuroendocrine tumors		ATR-X (alpha thalassemia/mental retardation) syndrome						15	163					4.75885e-15	8.10531e-15	0.00499	1	0
MAGT1	84061	broad.mit.edu	37	X	77112936	77112936	+	Missense_Mutation	SNP	C	C	A			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chrX:77112936C>A	uc004fof.2	-	4	607	c.545G>T	c.(544-546)CGG>CTG	p.R182L	MAGT1_uc004fog.3_RNA	NM_032121	NP_115497	Q9H0U3	MAGT1_HUMAN	magnesium transporter 1	150					protein N-linked glycosylation via asparagine	integral to membrane|oligosaccharyltransferase complex				upper_aerodigestive_tract(1)	1						TGTATCACCCCGTTTGGGTTT	0.423			NA											22	195					1.10513e-12	1.76877e-12	0.014323	1	0
PGK1	5230	broad.mit.edu	37	X	77380449	77380449	+	Missense_Mutation	SNP	C	C	A			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chrX:77380449C>A	uc004ecz.3	+	9	1187	c.1015C>A	c.(1015-1017)CCT>ACT	p.P339T	PGK1_uc010nlz.2_RNA|PGK1_uc011mqq.1_Missense_Mutation_p.P311T	NM_000291	NP_000282	P00558	PGK1_HUMAN	phosphoglycerate kinase 1	339					gluconeogenesis|glycolysis	cytosol	ATP binding|phosphoglycerate kinase activity			upper_aerodigestive_tract(1)|ovary(1)	2						GTGGAATGGTCCTGTGGGGGT	0.532			NA											13	157					0.00010058	0.00011441	0.013537	1	0
ZCCHC5	203430	broad.mit.edu	37	X	77913593	77913593	+	Missense_Mutation	SNP	G	G	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chrX:77913593G>T	uc004edc.1	-	2	621	c.325C>A	c.(325-327)CCA>ACA	p.P109T		NM_152694	NP_689907	Q8N8U3	ZCHC5_HUMAN	zinc finger, CCHC domain containing 5	109	Pro-rich.						nucleic acid binding|zinc ion binding			ovary(1)	1						GGGGCTGCTGGGGCCTCCTGG	0.642			NA											6	26					0.00116845	0.00128549	0.001168	1	0
P2RY10	27334	broad.mit.edu	37	X	78216850	78216850	+	Missense_Mutation	SNP	C	C	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chrX:78216850C>T	uc004ede.2	+	4	1202	c.833C>T	c.(832-834)CCC>CTC	p.P278L	P2RY10_uc004edf.2_Missense_Mutation_p.P278L	NM_014499	NP_055314	O00398	P2Y10_HUMAN	G-protein coupled purinergic receptor P2Y10	278	Extracellular (Potential).					integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			ovary(2)|lung(2)|breast(1)	5						AGCAGTTGTCCCGTTGTCCGA	0.418			NA											22	251					0	0	0.014323	0	0
APOOL	139322	broad.mit.edu	37	X	84342616	84342616	+	Missense_Mutation	SNP	G	G	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chrX:84342616G>T	uc004eem.2	+	9	753	c.739G>T	c.(739-741)GAC>TAC	p.D247Y	APOOL_uc010nmp.2_RNA	NM_198450	NP_940852	Q6UXV4	APOOL_HUMAN	apolipoprotein O-like precursor	247						extracellular region					0						GTTTATGCCTGACCCCAAGCT	0.338			NA											3	8					0.004672	0.00501021	0.004672	1	0
TGIF2LX	90316	broad.mit.edu	37	X	89177650	89177650	+	Missense_Mutation	SNP	C	C	G			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chrX:89177650C>G	uc004efe.2	+	2	615	c.566C>G	c.(565-567)CCG>CGG	p.P189R		NM_138960	NP_620410	Q8IUE1	TF2LX_HUMAN	TGFB-induced factor homeobox 2-like, X-linked	189						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|skin(1)	2						ATAGCCCAGCCGAAGAAAAAG	0.572			NA											12	75					0	0	0.010729	0	0
DIAPH2	1730	broad.mit.edu	37	X	96369926	96369926	+	Missense_Mutation	SNP	G	G	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chrX:96369926G>T	uc004efu.3	+	21	2947	c.2551G>T	c.(2551-2553)GCC>TCC	p.A851S	DIAPH2_uc004eft.3_Missense_Mutation_p.A851S	NM_006729	NP_006720	O60879	DIAP2_HUMAN	diaphanous 2 isoform 156	851	FH2.				cell differentiation|cytokinesis|multicellular organismal development|oogenesis	cytosol|early endosome|Golgi apparatus|mitochondrion|nucleolus	receptor binding|Rho GTPase binding			ovary(3)|lung(1)	4						CTCAAGAAATGCCCAGTCTTT	0.338			NA											3	38					0.004672	0.00501021	0.004672	1	0
GPRASP2	114928	broad.mit.edu	37	X	101970569	101970569	+	Missense_Mutation	SNP	C	C	A			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chrX:101970569C>A	uc004ejk.2	+	4	2106	c.772C>A	c.(772-774)CAC>AAC	p.H258N	GPRASP2_uc004ejl.2_Missense_Mutation_p.H258N|GPRASP2_uc004ejm.2_Missense_Mutation_p.H258N|GPRASP2_uc011mrp.1_5'Flank	NM_138437	NP_612446	Q96D09	GASP2_HUMAN	G protein-coupled receptor associated sorting	258						cytoplasm	protein binding			ovary(1)	1						CAGGTCCAGGCACAGGGCTAA	0.532			NA											34	155					1.04352e-10	1.56774e-10	0.003755	1	0
GPRASP2	114928	broad.mit.edu	37	X	101971085	101971085	+	Missense_Mutation	SNP	A	A	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chrX:101971085A>T	uc004ejk.2	+	4	2622	c.1288A>T	c.(1288-1290)AGT>TGT	p.S430C	GPRASP2_uc004ejl.2_Missense_Mutation_p.S430C|GPRASP2_uc004ejm.2_Missense_Mutation_p.S430C|GPRASP2_uc011mrp.1_5'Flank	NM_138437	NP_612446	Q96D09	GASP2_HUMAN	G protein-coupled receptor associated sorting	430						cytoplasm	protein binding			ovary(1)	1						GGAAAAGTCCAGTTTGGGGGC	0.577			NA											18	107					0	0	0.00499	0	0
IL1RAPL2	26280	broad.mit.edu	37	X	104993096	104993096	+	Missense_Mutation	SNP	G	G	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chrX:104993096G>T	uc004elz.1	+	9	1948	c.1192G>T	c.(1192-1194)GAC>TAC	p.D398Y		NM_017416	NP_059112	Q9NP60	IRPL2_HUMAN	interleukin 1 receptor accessory protein-like 2	398	Cytoplasmic (Potential).				central nervous system development|innate immune response	integral to membrane	interleukin-1, Type II, blocking receptor activity			breast(2)|ovary(1)	3						AACTAATGATGGTAAGCTGTC	0.294			NA											13	52					5.50884e-06	6.65869e-06	0.013537	1	0
SERPINA7	6906	broad.mit.edu	37	X	105277592	105277592	+	Missense_Mutation	SNP	G	G	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chrX:105277592G>T	uc004eme.1	-	4	1163	c.1147C>A	c.(1147-1149)CCT>ACT	p.P383T	SERPINA7_uc010npd.2_Missense_Mutation_p.P383T	NM_000354	NP_000345	P05543	THBG_HUMAN	serine (or cysteine) proteinase inhibitor, clade	383			P -> L (in TBG deficiency; Kumamoto).		regulation of proteolysis	extracellular space	serine-type endopeptidase inhibitor activity				0					Levothyroxine(DB00451)|Liothyronine(DB00279)	TGGATAATAGGGTGTAGGAAA	0.438			NA											54	340					1.0442e-30	1.98553e-30	0.01441	1	0
MORC4	79710	broad.mit.edu	37	X	106186365	106186365	+	Missense_Mutation	SNP	G	G	C			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chrX:106186365G>C	uc004emu.3	-	15	1999	c.1756C>G	c.(1756-1758)CCT>GCT	p.P586A	MORC4_uc004emp.3_Intron|MORC4_uc004emv.3_Missense_Mutation_p.P586A|MORC4_uc004emw.3_Missense_Mutation_p.P334A	NM_024657	NP_078933	Q8TE76	MORC4_HUMAN	zinc finger, CW type with coiled-coil domain 2	586							ATP binding|zinc ion binding			ovary(1)	1						TCTAGAGAAGGTGTTGTCATC	0.453			NA											30	169					0	0	0.008361	0	0
RBM41	55285	broad.mit.edu	37	X	106310791	106310791	+	Missense_Mutation	SNP	G	G	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chrX:106310791G>T	uc004emz.2	-	7	1239	c.1208C>A	c.(1207-1209)GCT>GAT	p.A403D	RBM41_uc004emy.1_Missense_Mutation_p.A403D	NM_018301	NP_060771	Q96IZ5	RBM41_HUMAN	RNA binding motif protein 41	403							nucleotide binding|RNA binding			ovary(1)	1						GCTACCTGTAGCACATGATAT	0.368			NA											35	230					2.09667e-21	3.86005e-21	0.003755	1	0
IRS4	8471	broad.mit.edu	37	X	107975899	107975899	+	Missense_Mutation	SNP	G	G	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chrX:107975899G>T	uc004eoc.2	-	1	3709	c.3676C>A	c.(3676-3678)CCG>ACG	p.P1226T		NM_003604	NP_003595	O14654	IRS4_HUMAN	insulin receptor substrate 4	1226						plasma membrane	insulin receptor binding|SH3/SH2 adaptor activity|signal transducer activity			ovary(4)|large_intestine(2)|lung(1)|breast(1)|skin(1)|pancreas(1)	10						TCTCTCTCCGGGGGTCTTGGC	0.572			NA											68	256					1.62914e-18	2.93984e-18	0.01441	1	0
AMMECR1	9949	broad.mit.edu	37	X	109560903	109560903	+	Missense_Mutation	SNP	A	A	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chrX:109560903A>T	uc004eoo.2	-	1	478	c.397T>A	c.(397-399)TTT>ATT	p.F133I	AMMECR1_uc004eop.2_Missense_Mutation_p.F133I|AMMECR1_uc004eoq.2_Missense_Mutation_p.F10I	NM_015365	NP_056180	Q9Y4X0	AMER1_HUMAN	AMMECR1 protein isoform 1	133	AMMECR1.										0						TCGAAGCAAAAGCAGCACATC	0.647			NA											7	26					0	0	0.001984	0	0
LUZP4	51213	broad.mit.edu	37	X	114540908	114540908	+	Nonsense_Mutation	SNP	C	C	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chrX:114540908C>T	uc004eqa.2	+	4	515	c.481C>T	c.(481-483)CGA>TGA	p.R161*	LUZP4_uc004eqb.2_Nonsense_Mutation_p.R79*	NM_016383	NP_057467	Q9P127	LUZP4_HUMAN	leucine zipper protein 4	161						nucleus				ovary(2)	2						TCATTCTGAGCGATCCCGAAA	0.463			NA											21	74					0	0	0.012319	0	0
ZCCHC12	170261	broad.mit.edu	37	X	117960036	117960036	+	Missense_Mutation	SNP	G	G	A			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chrX:117960036G>A	uc004equ.2	+	4	1302	c.829G>A	c.(829-831)GTG>ATG	p.V277M		NM_173798	NP_776159	Q6PEW1	ZCH12_HUMAN	zinc finger, CCHC domain containing 12	277					regulation of transcription, DNA-dependent|transcription, DNA-dependent		nucleic acid binding|zinc ion binding			ovary(1)	1						CGATGAGGATGTGATCCTGGT	0.567			NA											18	104					0	0	0.007413	0	0
CXorf56	63932	broad.mit.edu	37	X	118699205	118699205	+	Silent	SNP	G	G	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chrX:118699205G>T	uc004erk.1	-	1	160	c.114C>A	c.(112-114)GTC>GTA	p.V38V	CXorf56_uc004erj.1_5'UTR|CXorf56_uc011mtu.1_Silent_p.V38V	NM_022101	NP_071384	Q9H5V9	CX056_HUMAN	hypothetical protein LOC63932	38							protein binding				0						CCAGCACTAGGACCATCTGGC	0.582			NA											21	151					8.04996e-18	1.43636e-17	0.012319	1	0
GLUD2	2747	broad.mit.edu	37	X	120182641	120182641	+	Missense_Mutation	SNP	A	A	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chrX:120182641A>T	uc004eto.2	+	1	1180	c.1103A>T	c.(1102-1104)GAA>GTA	p.E368V		NM_012084	NP_036216	P49448	DHE4_HUMAN	glutamate dehydrogenase 2 precursor	368					glutamate biosynthetic process|glutamate catabolic process	mitochondrial matrix	ADP binding|glutamate dehydrogenase|glutamate dehydrogenase activity|GTP binding|leucine binding			pancreas(1)	1					L-Glutamic Acid(DB00142)|NADH(DB00157)	AAGCCCTATGAAGGAAGCATC	0.488			NA											34	225					0	0	0.012213	0	0
STAG2	10735	broad.mit.edu	37	X	123191729	123191729	+	Missense_Mutation	SNP	A	A	G			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chrX:123191729A>G	uc004etz.3	+	14	1657	c.1318A>G	c.(1318-1320)AGA>GGA	p.R440G	STAG2_uc004eua.2_Missense_Mutation_p.R440G|STAG2_uc004eub.2_Missense_Mutation_p.R440G|STAG2_uc004euc.2_Missense_Mutation_p.R440G|STAG2_uc004eud.2_Missense_Mutation_p.R440G|STAG2_uc004eue.2_Missense_Mutation_p.R440G	NM_006603	NP_006594	Q8N3U4	STAG2_HUMAN	stromal antigen 2 isoform b	440					cell division|meiosis|mitotic metaphase/anaphase transition|mitotic prometaphase|negative regulation of DNA endoreduplication|sister chromatid cohesion	chromatin|chromosome, centromeric region|nucleoplasm	protein binding			ovary(4)|skin(1)	5						CTTCAGTCGTAGAGATCCAGA	0.313			NA											4	36					0	0	0.000602	0	0
ODZ1	10178	broad.mit.edu	37	X	123779114	123779114	+	Missense_Mutation	SNP	C	C	A			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chrX:123779114C>A	uc004euj.2	-	10	1819	c.1755G>T	c.(1753-1755)AAG>AAT	p.K585N	ODZ1_uc011muj.1_Missense_Mutation_p.K584N|ODZ1_uc010nqy.2_Missense_Mutation_p.K585N	NM_014253	NP_055068	Q9UKZ4	TEN1_HUMAN	odz, odd Oz/ten-m homolog 1 isoform 3	585	EGF-like 2.|Extracellular (Potential).				immune response|negative regulation of cell proliferation|nervous system development|signal transduction	extracellular region	heparin binding			ovary(11)|breast(4)|large_intestine(2)|skin(2)|pancreas(2)|upper_aerodigestive_tract(1)|lung(1)	23						ACTCTGGCCCCTTCCAGCCAT	0.522			NA											68	272					2.18329e-32	4.16393e-32	0.01441	1	0
BCORL1	63035	broad.mit.edu	37	X	129147583	129147583	+	Missense_Mutation	SNP	G	G	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chrX:129147583G>T	uc004evb.1	+	4	949	c.835G>T	c.(835-837)GCC>TCC	p.A279S	BCORL1_uc010nrd.1_Missense_Mutation_p.A181S	NM_021946	NP_068765	Q5H9F3	BCORL_HUMAN	BCL6 co-repressor-like 1	279	Pro-rich.				chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus				ovary(4)|breast(2)|lung(1)	7						TTCTGTTTCGGCCTCAGTCTT	0.507			NA											25	126					3.65163e-15	6.23616e-15	0.00632	1	0
BCORL1	63035	broad.mit.edu	37	X	129149725	129149725	+	Missense_Mutation	SNP	C	C	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chrX:129149725C>T	uc004evb.1	+	4	3091	c.2977C>T	c.(2977-2979)CAT>TAT	p.H993Y	BCORL1_uc010nrd.1_Missense_Mutation_p.H895Y	NM_021946	NP_068765	Q5H9F3	BCORL_HUMAN	BCL6 co-repressor-like 1	993					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus				ovary(4)|breast(2)|lung(1)	7						CTACATGTCCCATGAGCTGGT	0.582			NA											28	116					0	0	0.00632	0	0
FRMD7	90167	broad.mit.edu	37	X	131212489	131212489	+	Missense_Mutation	SNP	G	G	C			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chrX:131212489G>C	uc004ewn.2	-	12	1734	c.1556C>G	c.(1555-1557)CCA>CGA	p.P519R	FRMD7_uc011muy.1_Missense_Mutation_p.P504R	NM_194277	NP_919253	Q6ZUT3	FRMD7_HUMAN	FERM domain containing 7	519					regulation of neuron projection development	cytoskeleton|growth cone|neuronal cell body	binding			skin(1)	1	Acute lymphoblastic leukemia(192;0.000127)					ATAGCTATGTGGACTTGTCCT	0.488			NA											37	203					0	0	0.006999	0	0
GPR112	139378	broad.mit.edu	37	X	135427714	135427714	+	Nonsense_Mutation	SNP	G	G	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chrX:135427714G>T	uc004ezu.1	+	6	2140	c.1849G>T	c.(1849-1851)GGA>TGA	p.G617*	GPR112_uc010nsb.1_Nonsense_Mutation_p.G412*|GPR112_uc010nsc.1_Nonsense_Mutation_p.G384*	NM_153834	NP_722576	Q8IZF6	GP112_HUMAN	G-protein coupled receptor 112	617	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(5)|large_intestine(2)|skin(2)|lung(1)|breast(1)|pancreas(1)	12	Acute lymphoblastic leukemia(192;0.000127)					TACAGCTGATGGACACTTGCT	0.473			NA											15	82					1.49906e-05	1.77162e-05	0.00245	1	0
GPR112	139378	broad.mit.edu	37	X	135429187	135429187	+	Nonsense_Mutation	SNP	G	G	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chrX:135429187G>T	uc004ezu.1	+	6	3613	c.3322G>T	c.(3322-3324)GAA>TAA	p.E1108*	GPR112_uc010nsb.1_Nonsense_Mutation_p.E903*|GPR112_uc010nsc.1_Nonsense_Mutation_p.E875*	NM_153834	NP_722576	Q8IZF6	GP112_HUMAN	G-protein coupled receptor 112	1108	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(5)|large_intestine(2)|skin(2)|lung(1)|breast(1)|pancreas(1)	12	Acute lymphoblastic leukemia(192;0.000127)					TTCTCTGACAGAAACACCATT	0.473			NA											44	197					1.7489e-18	3.14704e-18	0.011902	1	0
CD40LG	959	broad.mit.edu	37	X	135741549	135741549	+	Missense_Mutation	SNP	C	C	A			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chrX:135741549C>A	uc004faa.2	+	5	833	c.761C>A	c.(760-762)ACG>AAG	p.T254K	CD40LG_uc010nsd.2_Missense_Mutation_p.T233K	NM_000074	NP_000065	P29965	CD40L_HUMAN	CD40 ligand	254	Extracellular (Potential).		T -> M (in HIGM1).		anti-apoptosis|B cell proliferation|inflammatory response|isotype switching|leukocyte cell-cell adhesion|platelet activation|positive regulation of endothelial cell apoptosis|positive regulation of interleukin-12 production	extracellular space|integral to plasma membrane|soluble fraction	CD40 receptor binding|cytokine activity|tumor necrosis factor receptor binding			skin(1)	1	Acute lymphoblastic leukemia(192;0.000127)				Atorvastatin(DB01076)	ACTGGCTTCACGTCCTTTGGC	0.507			NA							Immune_Deficiency_with_Hyper-IgM				19	107					8.28177e-16	1.43356e-15	0.007413	1	0
GPR101	83550	broad.mit.edu	37	X	136112640	136112640	+	Silent	SNP	A	A	G			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chrX:136112640A>G	uc011mwh.1	-	1	1194	c.1194T>C	c.(1192-1194)GCT>GCC	p.A398A		NM_054021	NP_473362	Q96P66	GP101_HUMAN	G protein-coupled receptor 101	398	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(3)|lung(1)|skin(1)	5	Acute lymphoblastic leukemia(192;0.000127)					AGATCACTTTAGCAGCTTTGC	0.547			NA											16	76					0	0	0.003163	0	0
SOX3	6658	broad.mit.edu	37	X	139586844	139586844	+	Missense_Mutation	SNP	T	T	A			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chrX:139586844T>A	uc004fbd.1	-	1	382	c.382A>T	c.(382-384)AGC>TGC	p.S128C		NM_005634	NP_005625	P41225	SOX3_HUMAN	SRY (sex determining region Y)-box 3	128					face development|hypothalamus development|negative regulation of neuron differentiation|pituitary gland development|regulation of transcription, DNA-dependent|sensory organ development|sex determination|transcription, DNA-dependent	nucleus	DNA binding			pancreas(1)	1	Acute lymphoblastic leukemia(192;7.65e-05)					CCACCTCCGCTCGCACCACCG	0.721			NA											7	42					0	0	0.00308	0	0
MAGEC3	139081	broad.mit.edu	37	X	140984797	140984797	+	Missense_Mutation	SNP	C	C	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chrX:140984797C>T	uc011mwp.1	+	7	1253	c.1253C>T	c.(1252-1254)TCC>TTC	p.S418F	MAGEC3_uc004fbs.2_Missense_Mutation_p.S120F|MAGEC3_uc010nsj.2_Missense_Mutation_p.S120F	NM_138702	NP_619647	Q8TD91	MAGC3_HUMAN	melanoma antigen family C, 3 isoform 1	418										skin(2)|central_nervous_system(1)	3	Acute lymphoblastic leukemia(192;6.56e-05)					cctcTAGACTCCTGCTCATCC	0.358			NA											3	20					0	0	0.004672	0	0
MAGEA8	4107	broad.mit.edu	37	X	149013098	149013098	+	Missense_Mutation	SNP	G	G	A			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chrX:149013098G>A	uc004fdw.1	+	3	267	c.52G>A	c.(52-54)GCC>ACC	p.A18T		NM_005364	NP_005355	P43361	MAGA8_HUMAN	melanoma antigen family A, 8	18											0	Acute lymphoblastic leukemia(192;6.56e-05)					AGGCCTTCAGGCCCAAGGAGA	0.577			NA											8	26					0	0	0.00308	0	0
MAGEA10	4109	broad.mit.edu	37	X	151303513	151303513	+	Missense_Mutation	SNP	C	C	A			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chrX:151303513C>A	uc004ffk.2	-	5	988	c.580G>T	c.(580-582)GTG>TTG	p.V194L	MAGEA10_uc004ffl.2_Missense_Mutation_p.V194L	NM_001011543	NP_001011543	P43363	MAGAA_HUMAN	melanoma antigen family A, 10	194	MAGE.										0	Acute lymphoblastic leukemia(192;6.56e-05)					GTGGGATCCACTTCCTTTACA	0.498			NA											19	104					5.35267e-07	6.9727e-07	0.007413	1	0
MAGEA6	4105	broad.mit.edu	37	X	151869560	151869560	+	Missense_Mutation	SNP	T	T	G			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chrX:151869560T>G	uc004ffq.1	+	3	444	c.250T>G	c.(250-252)TAT>GAT	p.Y84D	MAGEA6_uc004ffr.1_Missense_Mutation_p.Y84D|MAGEA2_uc010nto.2_Intron	NM_005363	NP_005354	P43360	MAGA6_HUMAN	melanoma antigen family A, 6	84							protein binding				0	Acute lymphoblastic leukemia(192;6.56e-05)					GAGCCAATCCTATGAGGACTC	0.597			NA											21	86					0	0	0.003954	0	0
CETN2	1069	broad.mit.edu	37	X	151996441	151996441	+	Missense_Mutation	SNP	C	C	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chrX:151996441C>T	uc004fgq.2	-	5	510	c.463G>A	c.(463-465)GGA>AGA	p.G155R	CETN2_uc004fgr.2_Missense_Mutation_p.G84R	NM_004344	NP_004335	P41208	CETN2_HUMAN	caltractin	155	2.|EF-hand 4.				cell division|centriole replication|G2/M transition of mitotic cell cycle|mitosis|nucleotide-excision repair|regulation of cytokinesis	centriole|cytosol|XPC complex	ATP binding|ATP-dependent helicase activity|calcium ion binding|nucleic acid binding				0	Acute lymphoblastic leukemia(192;6.56e-05)					CTGACCTCTCCATCTCCATCT	0.373			NA						Direct_reversal_of_damage|NER					20	110					0	0	0.010504	0	0
PNMA5	114824	broad.mit.edu	37	X	152159318	152159318	+	Missense_Mutation	SNP	G	G	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chrX:152159318G>T	uc010ntw.2	-	3	1164	c.825C>A	c.(823-825)CAC>CAA	p.H275Q	PNMA5_uc004fha.3_Missense_Mutation_p.H275Q|PNMA5_uc010ntx.2_Missense_Mutation_p.H275Q|PNMA5_uc004fgy.3_Missense_Mutation_p.H275Q	NM_001103151	NP_001096621	Q96PV4	PNMA5_HUMAN	paraneoplastic antigen like 5	275					apoptosis					ovary(1)|skin(1)	2	Acute lymphoblastic leukemia(192;6.56e-05)					AGGGGCTCTTGTGCACGGCTT	0.567			NA											26	96					2.27525e-19	4.15283e-19	0.003954	1	0
PNMA3	29944	broad.mit.edu	37	X	152226044	152226044	+	Missense_Mutation	SNP	G	G	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chrX:152226044G>T	uc004fhc.2	+	2	968	c.632G>T	c.(631-633)GGC>GTC	p.G211V	PNMA5_uc004fha.3_5'Flank|PNMA3_uc004fhd.2_5'Flank	NM_013364	NP_037496	Q9UL41	PNMA3_HUMAN	paraneoplastic cancer-testis-brain antigen	211					apoptosis	nucleolus	nucleic acid binding|zinc ion binding			skin(2)|large_intestine(1)	3	Acute lymphoblastic leukemia(192;6.56e-05)					tgcttacggggccctgctctc	0			NA											20	135					9.7654e-05	0.00011148	0.007413	1	0
MECP2	4204	broad.mit.edu	37	X	153295921	153295921	+	Missense_Mutation	SNP	C	C	A	rs61753980		TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chrX:153295921C>A	uc004fjv.2	-	4	1584	c.1358G>T	c.(1357-1359)CGA>CTA	p.R453L	MECP2_uc004fjw.2_Missense_Mutation_p.R465L	NM_004992	NP_004983	P51608	MECP2_HUMAN	methyl CpG binding protein 2 isoform 1	453			R -> Q (in MRXS13).		negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	heterochromatin|nucleus	double-stranded methylated DNA binding|protein domain specific binding|protein N-terminus binding|transcription corepressor activity				0	all_cancers(53;3.7e-16)|all_epithelial(53;3.44e-10)|all_lung(58;2.06e-07)|Lung NSC(58;2.72e-07)|all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					TCCCTCCCCTCGGTGTTTGTA	0.622			NA											79	450					7.83748e-43	1.51287e-42	0.01441	1	0
SLC10A3	8273	broad.mit.edu	37	X	153716657	153716657	+	Missense_Mutation	SNP	C	C	A			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chrX:153716657C>A	uc004flq.2	-	3	887	c.623G>T	c.(622-624)GGG>GTG	p.G208V	UBL4A_uc004flo.2_5'Flank|SLC10A3_uc004flr.2_Missense_Mutation_p.G179V|SLC10A3_uc004flp.2_Missense_Mutation_p.G208V	NM_001142392	NP_001135864	P09131	P3_HUMAN	solute carrier family 10, member 3 isoform 1	208					organic anion transport	integral to membrane	bile acid:sodium symporter activity			ovary(1)|skin(1)	2	all_cancers(53;5.05e-16)|all_epithelial(53;1.87e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					CACTTTGCACCCAAACGAACA	0.587			NA											24	156					1.9806e-07	2.63391e-07	0.014323	1	0
Unknown	0	broad.mit.edu	37	X	155254735	155254735	+	Missense_Mutation	SNP	C	C	G			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chrX:155254735C>G	uc004fnx.3	+	8	1085	c.631C>G	c.(631-633)CTC>GTC	p.L211V		NM_182905	NP_878908			WAS protein family homolog 1												NA						GATGTCGGATCTCTTCAACAA	0.587			NA											3	8					0	0	0.004672	0	0
GJA8	2703	broad.mit.edu	37	1	147380436	147380436	+	Frame_Shift_Del	DEL	G	G	-			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr1:147380436delG	uc001epu.1	+	2	417	c.354delG	c.(352-354)GCGfs	p.A118fs		NM_005267	NP_005258	P48165	CXA8_HUMAN	connexin 50	118	Cytoplasmic (Potential).				cell communication|visual perception	connexon complex|integral to plasma membrane	channel activity			ovary(2)|large_intestine(2)|breast(1)|skin(1)	6	all_hematologic(923;0.0276)					GCCAGCAGGCGGGGACTAACG	0.662	Melanoma(76;1255 1795 8195 52096)		NA											42	96	---	---	---	---	NA	NA	NA	NA	NA
OR52N4	390072	broad.mit.edu	37	11	5776795	5776795	+	Frame_Shift_Del	DEL	C	C	-			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr11:5776795delC	uc001mbu.2	+	1	873	c.825delC	c.(823-825)TGCfs	p.C275fs	TRIM5_uc001mbq.1_Intron|TRIM22_uc009yet.1_Intron	NM_001005175	NP_001005175	Q8NGI2	O52N4_HUMAN	olfactory receptor, family 52, subfamily N,	275	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;1.87e-10)|LUSC - Lung squamous cell carcinoma(625;0.114)|BRCA - Breast invasive adenocarcinoma(625;0.135)|Lung(200;0.197)		CCCCTTCTTGCCACATCATTG	0.458			NA											13	161	---	---	---	---	NA	NA	NA	NA	NA
KRTAP5-10	387273	broad.mit.edu	37	11	71276873	71276874	+	Frame_Shift_Ins	INS	-	-	A			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr11:71276873_71276874insA	uc001oqt.1	+	1	265_266	c.240_241insA	c.(238-243)TCCAAAfs	p.S80fs		NM_001012710	NP_001012728	Q6L8G5	KR510_HUMAN	keratin associated protein 5-10	80_81	7 X 4 AA repeats of C-C-X-P.					keratin filament				skin(1)	1						GTGGGGGCTCCAAAGGGGGCTG	0.683			NA											34	266	---	---	---	---	NA	NA	NA	NA	NA
SCN2B	6327	broad.mit.edu	37	11	118037787	118037787	+	Frame_Shift_Del	DEL	C	C	-			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr11:118037787delC	uc001psf.2	-	4	654	c.463delG	c.(463-465)GACfs	p.D155fs		NM_004588	NP_004579	O60939	SCN2B_HUMAN	sodium channel, voltage-gated, type II, beta	155	Extracellular (Potential).				synaptic transmission	voltage-gated sodium channel complex	voltage-gated sodium channel activity				0	all_hematologic(175;0.046)	Medulloblastoma(222;0.0425)|Breast(348;0.181)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;3.19e-05)|Epithelial(105;0.00117)		ACCGTGGAGTCCCGCTCAGGG	0.617			NA											10	51	---	---	---	---	NA	NA	NA	NA	NA
PRB4	5545	broad.mit.edu	37	12	11461410	11461410	+	Frame_Shift_Del	DEL	T	T	-			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr12:11461410delT	uc001qzf.1	-	3	541	c.507delA	c.(505-507)GAAfs	p.E169fs	PRB4_uc001qzt.2_Frame_Shift_Del_p.E169fs	NM_002723	NP_002714	P10163	PRB4_HUMAN	proline-rich protein BstNI subfamily 4	232	9.5 X 21 AA tandem repeats of K-P-[EQ]- [GR]-[PR]-[PR]-P-Q-G-G-N-Q-[PS]-[QH]- [RG]-[PT]-P-P-[PH]-P-G.|10; truncated.					extracellular region				ovary(1)	1						ACTTGTTTCCTTCCTGTGGGG	0.587			NA								HNSCC(22;0.051)			74	405	---	---	---	---	NA	NA	NA	NA	NA
ZCRB1	85437	broad.mit.edu	37	12	42717844	42717844	+	Frame_Shift_Del	DEL	G	G	-			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr12:42717844delG	uc001rmz.2	-	2	270	c.61delC	c.(61-63)CTGfs	p.L21fs	PPHLN1_uc001rmy.2_Intron|PPHLN1_uc001rna.2_5'Flank|PPHLN1_uc001rne.2_5'Flank|PPHLN1_uc001rnb.2_5'Flank|PPHLN1_uc001rnd.2_5'Flank|PPHLN1_uc001rnc.2_5'Flank|PPHLN1_uc001rnf.2_5'Flank|PPHLN1_uc010skq.1_5'Flank|PPHLN1_uc010skr.1_5'Flank|PPHLN1_uc001rng.1_5'Flank|PPHLN1_uc010sks.1_5'Flank|PPHLN1_uc010skt.1_5'Flank|PPHLN1_uc001rni.1_5'Flank|PPHLN1_uc001rnh.1_5'Flank|PPHLN1_uc010sku.1_5'Flank	NM_033114	NP_149105	Q8TBF4	ZCRB1_HUMAN	zinc finger CCHC-type and RNA binding motif 1	21	RRM.				mRNA processing	nucleoplasm|U12-type spliceosomal complex	nucleotide binding|RNA binding|zinc ion binding			skin(1)	1	all_cancers(12;0.000348)|Breast(8;0.221)	Lung NSC(34;0.123)		GBM - Glioblastoma multiforme(48;0.0689)		TTGTTTGTCAGGGAAAAAGGC	0.378			NA											21	71	---	---	---	---	NA	NA	NA	NA	NA
TMEM132B	114795	broad.mit.edu	37	12	126138827	126138827	+	Frame_Shift_Del	DEL	G	G	-			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr12:126138827delG	uc001uhe.1	+	9	2816	c.2808delG	c.(2806-2808)CAGfs	p.Q936fs	TMEM132B_uc001uhf.1_Frame_Shift_Del_p.Q448fs	NM_052907	NP_443139	Q14DG7	T132B_HUMAN	transmembrane protein 132B	936	Cytoplasmic (Potential).					integral to membrane				skin(11)|ovary(5)|large_intestine(1)|pancreas(1)|breast(1)	19	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000423)|Epithelial(86;0.00394)|all cancers(50;0.0362)		TGAGTGAGCAGGGCAACATCC	0.512			NA											9	95	---	---	---	---	NA	NA	NA	NA	NA
SMOC1	64093	broad.mit.edu	37	14	70477560	70477561	+	Frame_Shift_Ins	INS	-	-	C			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr14:70477560_70477561insC	uc001xls.1	+	8	1007_1008	c.754_755insC	c.(754-756)GCCfs	p.A252fs	SMOC1_uc001xlt.1_Frame_Shift_Ins_p.A252fs	NM_022137	NP_071420	Q9H4F8	SMOC1_HUMAN	secreted modular calcium-binding protein 1	252	Thyroglobulin type-1 2.				cell differentiation|eye development|limb development|regulation of osteoblast differentiation|signal transduction	basement membrane	calcium ion binding			upper_aerodigestive_tract(1)|pancreas(1)	2				all cancers(60;0.00417)|BRCA - Breast invasive adenocarcinoma(234;0.0119)|OV - Ovarian serous cystadenocarcinoma(108;0.028)		CCCTGAATGTGCCCCTGGGGGA	0.589			NA											34	119	---	---	---	---	NA	NA	NA	NA	NA
KIFC3	3801	broad.mit.edu	37	16	57803530	57803530	+	Frame_Shift_Del	DEL	C	C	-			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr16:57803530delC	uc002emp.2	-	9	1392	c.1195delG	c.(1195-1197)GCCfs	p.A399fs	KIFC3_uc010vhw.1_Frame_Shift_Del_p.A297fs|KIFC3_uc002emn.2_RNA|KIFC3_uc002emm.2_Frame_Shift_Del_p.A260fs|KIFC3_uc010vhx.1_Frame_Shift_Del_p.A260fs|KIFC3_uc010cdf.2_Frame_Shift_Del_p.A260fs|KIFC3_uc002emo.3_Frame_Shift_Del_p.A260fs|KIFC3_uc010vhy.1_Frame_Shift_Del_p.A341fs|KIFC3_uc002emq.2_Frame_Shift_Del_p.A399fs|KIFC3_uc010vhz.1_Frame_Shift_Del_p.A421fs|KIFC3_uc002emr.1_Frame_Shift_Del_p.A176fs	NM_005550	NP_005541	Q9BVG8	KIFC3_HUMAN	kinesin family member C3 isoform 1	399	Potential.				epithelial cell-cell adhesion|microtubule-based movement|visual perception|zonula adherens maintenance	centrosome|cytoplasmic vesicle membrane|kinesin complex|microtubule|zonula adherens	ATP binding|microtubule motor activity			central_nervous_system(2)|ovary(1)	3		all_neural(199;0.224)				CTCCTGAGGGCCTCCTGCAGC	0.657			NA											27	72	---	---	---	---	NA	NA	NA	NA	NA
DNAH9	1770	broad.mit.edu	37	17	11554601	11554601	+	Frame_Shift_Del	DEL	C	C	-			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr17:11554601delC	uc002gne.2	+	13	2381	c.2313delC	c.(2311-2313)CGCfs	p.R771fs	DNAH9_uc010coo.2_Frame_Shift_Del_p.R65fs	NM_001372	NP_001363	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9 isoform 2	771	Stem (By similarity).|Potential.		R -> L (in a breast cancer sample; somatic mutation).		cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity	p.R771L(1)		skin(10)|ovary(4)|breast(3)|central_nervous_system(2)|pancreas(1)	20		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		TTGATCTCCGCCTCAGAGCAG	0.418			NA											21	59	---	---	---	---	NA	NA	NA	NA	NA
CTAGE1	64693	broad.mit.edu	37	18	19995559	19995559	+	Frame_Shift_Del	DEL	A	A	-			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr18:19995559delA	uc002ktv.1	-	1	2320	c.2216delT	c.(2215-2217)TTCfs	p.F739fs		NM_172241	NP_758441	Q96RT6	CTGE2_HUMAN	cutaneous T-cell lymphoma-associated antigen 1	739	Pro-rich.					integral to membrane				ovary(1)	1	all_cancers(21;0.000361)|all_epithelial(16;9.61e-06)|Colorectal(14;0.0533)|Lung NSC(20;0.0605)|Ovarian(2;0.116)|all_lung(20;0.135)					GGCTGGGGGGAAAAATGCAGG	0.502			NA											18	48	---	---	---	---	NA	NA	NA	NA	NA
ADNP2	22850	broad.mit.edu	37	18	77895005	77895006	+	Frame_Shift_Ins	INS	-	-	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr18:77895005_77895006insT	uc002lnw.2	+	4	2164_2165	c.1709_1710insT	c.(1708-1710)ACTfs	p.T570fs		NM_014913	NP_055728	Q6IQ32	ADNP2_HUMAN	ADNP homeobox 2	570					cellular response to oxidative stress|cellular response to retinoic acid|negative regulation of cell death|neuron differentiation|positive regulation of cell growth	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)|breast(3)|central_nervous_system(1)	8		all_cancers(4;1.06e-15)|all_epithelial(4;2.36e-10)|all_lung(4;0.000302)|Lung NSC(4;0.000518)|Esophageal squamous(42;0.0212)|Ovarian(4;0.0256)|all_hematologic(56;0.15)|Melanoma(33;0.2)		Epithelial(2;1.1e-11)|OV - Ovarian serous cystadenocarcinoma(15;7.54e-09)|BRCA - Breast invasive adenocarcinoma(31;0.00247)|STAD - Stomach adenocarcinoma(84;0.164)		CTCAACCAGACTGTGGGCACCA	0.55			NA											22	88	---	---	---	---	NA	NA	NA	NA	NA
NUMBL	9253	broad.mit.edu	37	19	41173866	41173868	+	In_Frame_Del	DEL	TGC	TGC	-			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	TGC	TGC	-	-	TGC	TGC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr19:41173866_41173868delTGC	uc002oon.2	-	10	1503_1505	c.1335_1337delGCA	c.(1333-1338)CAGCAA>CAA	p.445_446QQ>Q	NUMBL_uc010xvq.1_In_Frame_Del_p.404_405QQ>Q|NUMBL_uc002ooo.2_In_Frame_Del_p.444_445QQ>Q|NUMBL_uc010xvr.1_In_Frame_Del_p.404_405QQ>Q	NM_004756	NP_004747	Q9Y6R0	NUMBL_HUMAN	numb homolog (Drosophila)-like	445_446	Poly-Gln.				cytokine-mediated signaling pathway|lateral ventricle development|neuroblast division in subventricular zone|protein metabolic process	cytoplasm	protein binding			lung(3)|ovary(1)|breast(1)	5			Lung(22;0.000393)|LUSC - Lung squamous cell carcinoma(20;0.00105)			TGAGgctgcttgctgctgttgct	0.473			NA											3	5	---	---	---	---	NA	NA	NA	NA	NA
CCDC142	84865	broad.mit.edu	37	2	74709220	74709220	+	Frame_Shift_Del	DEL	T	T	-			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr2:74709220delT	uc002slr.2	-	1	1138	c.745delA	c.(745-747)AGTfs	p.S249fs	TTC31_uc002sls.2_5'Flank|TTC31_uc010yrv.1_5'Flank|TTC31_uc002slt.2_5'Flank|TTC31_uc002slu.2_5'Flank|CCDC142_uc002slo.2_RNA|CCDC142_uc002slq.2_Frame_Shift_Del_p.S249fs|CCDC142_uc002slp.2_Frame_Shift_Del_p.S249fs	NM_032779	NP_116168	Q17RM4	CC142_HUMAN	coiled-coil domain containing 142	249										central_nervous_system(1)	1						TCCAGCCGACTTGCCACCTGG	0.677			NA											18	52	---	---	---	---	NA	NA	NA	NA	NA
ADAMTS1	9510	broad.mit.edu	37	21	28212020	28212020	+	Frame_Shift_Del	DEL	C	C	-			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr21:28212020delC	uc002ymf.2	-	7	2369	c.1914delG	c.(1912-1914)GGGfs	p.G638fs		NM_006988	NP_008919	Q9UHI8	ATS1_HUMAN	ADAM metallopeptidase with thrombospondin type 1	638	Cys-rich.				integrin-mediated signaling pathway|negative regulation of cell proliferation|proteolysis		heparin binding|zinc ion binding			lung(3)|large_intestine(2)|central_nervous_system(1)	6		Breast(209;0.000962)		Lung(58;0.215)		CAGGCCCACTCCCAAAGGAAG	0.458			NA											25	99	---	---	---	---	NA	NA	NA	NA	NA
PFKL	5211	broad.mit.edu	37	21	45730904	45730904	+	Frame_Shift_Del	DEL	G	G	-	rs150271960		TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr21:45730904delG	uc002zel.2	+	3	234	c.175delG	c.(175-177)GTGfs	p.V59fs	PFKL_uc002zek.2_Frame_Shift_Del_p.V106fs|PFKL_uc011afd.1_Frame_Shift_Del_p.V106fs	NM_002626	NP_002617	P17858	K6PL_HUMAN	liver phosphofructokinase	59					fructose 6-phosphate metabolic process|glycolysis|protein oligomerization	6-phosphofructokinase complex	6-phosphofructokinase activity|ATP binding|fructose-6-phosphate binding|identical protein binding|kinase binding|metal ion binding				0				Colorectal(79;0.0811)		TGAGGGCCTCGTGGAGGGAGG	0.597			NA											12	35	---	---	---	---	NA	NA	NA	NA	NA
TRH	7200	broad.mit.edu	37	3	129695643	129695643	+	Frame_Shift_Del	DEL	G	G	-			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr3:129695643delG	uc003enc.2	+	3	874	c.313delG	c.(313-315)GGGfs	p.G105fs		NM_007117	NP_009048	P20396	TRH_HUMAN	thyrotropin-releasing hormone	105					cell-cell signaling|hormone-mediated signaling pathway	extracellular region|soluble fraction	neuropeptide hormone activity|thyrotropin-releasing hormone activity			ovary(1)	1						agaggaagaagggggggCTGT	0.418	Esophageal Squamous(60;321 1330 17401 41911)		NA											7	63	---	---	---	---	NA	NA	NA	NA	NA
SAMD7	344658	broad.mit.edu	37	3	169644460	169644467	+	Frame_Shift_Del	DEL	CTGCCTAC	CTGCCTAC	-			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	CTGCCTAC	CTGCCTAC	-	-	CTGCCTAC	CTGCCTAC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr3:169644460_169644467delCTGCCTAC	uc003fgd.2	+	6	677_684	c.410_417delCTGCCTAC	c.(409-417)GCTGCCTACfs	p.A137fs	SAMD7_uc003fge.2_Frame_Shift_Del_p.A137fs|SAMD7_uc011bpo.1_Frame_Shift_Del_p.A38fs	NM_182610	NP_872416	Q7Z3H4	SAMD7_HUMAN	sterile alpha motif domain containing 7	137_139										skin(1)	1	all_cancers(22;1.55e-22)|all_epithelial(15;2.41e-27)|all_lung(20;3.52e-17)|Lung NSC(18;1.44e-16)|Ovarian(172;0.000337)|Breast(254;0.169)		Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.0106)			GCTGCCCCCGCTGCCTACCATGGCAGGA	0.548			NA											8	76	---	---	---	---	NA	NA	NA	NA	NA
UNC5C	8633	broad.mit.edu	37	4	96171725	96171725	+	Frame_Shift_Del	DEL	G	G	-			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr4:96171725delG	uc003htp.1	-	5	842	c.688delC	c.(688-690)CGAfs	p.R230fs	UNC5C_uc010ilc.1_Frame_Shift_Del_p.R230fs|UNC5C_uc003htq.2_Frame_Shift_Del_p.R230fs	NM_003728	NP_003719	O95185	UNC5C_HUMAN	unc5C precursor	230	Extracellular (Potential).|Ig-like C2-type.				apoptosis|axon guidance|brain development	integral to membrane	netrin receptor activity			ovary(3)|pancreas(1)	4		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;8.72e-10)		TCAGAGAGTCGGGCCTGCTTT	0.398			NA											34	157	---	---	---	---	NA	NA	NA	NA	NA
PCDH10	57575	broad.mit.edu	37	4	134073021	134073039	+	Frame_Shift_Del	DEL	GCGCCTCTACCAGGGCGCA	GCGCCTCTACCAGGGCGCA	-			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	GCGCCTCTACCAGGGCGCA	GCGCCTCTACCAGGGCGCA	-	-	GCGCCTCTACCAGGGCGCA	GCGCCTCTACCAGGGCGCA	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr4:134073021_134073039delGCGCCTCTACCAGGGCGCA	uc003iha.2	+	1	2552_2570	c.1726_1744delGCGCCTCTACCAGGGCGCA	c.(1726-1746)GCGCCTCTACCAGGGCGCAACfs	p.A576fs	uc003igy.2_5'Flank|PCDH10_uc003igz.2_Frame_Shift_Del_p.A576fs	NM_032961	NP_116586	Q9P2E7	PCD10_HUMAN	protocadherin 10 isoform 1 precursor	576_582	Cadherin 6.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)	2				LUSC - Lung squamous cell carcinoma(193;0.227)		TGCCATCGTGGCGCCTCTACCAGGGCGCAACGGGACTCC	0.694			NA											7	86	---	---	---	---	NA	NA	NA	NA	NA
TLL1	7092	broad.mit.edu	37	4	166964494	166964494	+	Frame_Shift_Del	DEL	C	C	-			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr4:166964494delC	uc003irh.1	+	12	2094	c.1447delC	c.(1447-1449)CGCfs	p.R483fs	TLL1_uc011cjn.1_Frame_Shift_Del_p.R483fs|TLL1_uc011cjo.1_Frame_Shift_Del_p.R307fs	NM_012464	NP_036596	O43897	TLL1_HUMAN	tolloid-like 1 precursor	483	CUB 2.				cell differentiation|proteolysis|skeletal system development	extracellular region	calcium ion binding|metalloendopeptidase activity|zinc ion binding			skin(3)|ovary(2)|breast(1)|central_nervous_system(1)	7	all_hematologic(180;0.221)	Melanoma(52;0.0315)|Prostate(90;0.0405)		GBM - Glioblastoma multiforme(119;0.103)		TGATGACTATCGCCCGATGAA	0.413			NA											17	95	---	---	---	---	NA	NA	NA	NA	NA
TTK	7272	broad.mit.edu	37	6	80745022	80745023	+	Frame_Shift_Ins	INS	-	-	G	rs55918562		TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr6:80745022_80745023insG	uc003pjc.2	+	16	1886_1887	c.1812_1813insG	c.(1810-1815)TGTGGAfs	p.C604fs	TTK_uc003pjb.3_Frame_Shift_Ins_p.C603fs	NM_003318	NP_003309	P33981	TTK_HUMAN	TTK protein kinase	604_605	Protein kinase.				mitotic cell cycle spindle assembly checkpoint|mitotic spindle organization|positive regulation of cell proliferation|positive regulation of pathway-restricted SMAD protein phosphorylation	spindle	ATP binding|identical protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(4)|stomach(2)|lung(2)|large_intestine(2)|pancreas(1)	11		all_cancers(76;0.00177)|Acute lymphoblastic leukemia(125;1.24e-05)|all_hematologic(105;0.00223)|all_epithelial(107;0.2)		BRCA - Breast invasive adenocarcinoma(397;0.0321)		TAATGGAGTGTGGAAATATTGA	0.327			NA											15	48	---	---	---	---	NA	NA	NA	NA	NA
TAAR6	319100	broad.mit.edu	37	6	132891761	132891761	+	Frame_Shift_Del	DEL	G	G	-			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr6:132891761delG	uc011eck.1	+	1	301	c.301delG	c.(301-303)GGGfs	p.G101fs		NM_175067	NP_778237	Q96RI8	TAAR6_HUMAN	trace amine associated receptor 6	101	Extracellular (Potential).					plasma membrane	G-protein coupled receptor activity			ovary(2)|skin(1)	3	Breast(56;0.112)			OV - Ovarian serous cystadenocarcinoma(155;0.006)|GBM - Glioblastoma multiforme(226;0.00792)		CTGGTATTTTGGGAGGAGTTT	0.493			NA											37	119	---	---	---	---	NA	NA	NA	NA	NA
ELMO1	9844	broad.mit.edu	37	7	37354511	37354512	+	Frame_Shift_Ins	INS	-	-	T			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr7:37354511_37354512insT	uc003tfk.1	-	4	441_442	c.134_135insA	c.(133-135)AACfs	p.N45fs	ELMO1_uc010kxg.1_Frame_Shift_Ins_p.N45fs	NM_014800	NP_055615	Q92556	ELMO1_HUMAN	engulfment and cell motility 1 isoform 1	45					actin cytoskeleton organization|apoptosis|cellular component movement|phagocytosis, engulfment|Rac protein signal transduction|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|plasma membrane	SH3 domain binding			ovary(3)|skin(2)|upper_aerodigestive_tract(1)	6						AATATTCATGGTTGGCAAGAGA	0.332			NA											8	33	---	---	---	---	NA	NA	NA	NA	NA
OR2A12	346525	broad.mit.edu	37	7	143792483	143792483	+	Frame_Shift_Del	DEL	C	C	-			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr7:143792483delC	uc011kty.1	+	1	283	c.283delC	c.(283-285)CCTfs	p.P95fs		NM_001004135	NP_001004135	Q8NGT7	O2A12_HUMAN	olfactory receptor, family 2, subfamily A,	95	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|central_nervous_system(1)	3	Melanoma(164;0.0783)					CTCCTTTGCTCCTTGCATACT	0.443			NA											21	77	---	---	---	---	NA	NA	NA	NA	NA
C9orf131	138724	broad.mit.edu	37	9	35043876	35043887	+	In_Frame_Del	DEL	GAGAAAACTCAG	GAGAAAACTCAG	-			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	GAGAAAACTCAG	GAGAAAACTCAG	-	-	GAGAAAACTCAG	GAGAAAACTCAG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr9:35043876_35043887delGAGAAAACTCAG	uc003zvw.2	+	2	1279_1290	c.1250_1261delGAGAAAACTCAG	c.(1249-1263)AGAGAAAACTCAGGA>AGA	p.ENSG418del	C9orf131_uc003zvu.2_In_Frame_Del_p.ENSG370del|C9orf131_uc003zvv.2_In_Frame_Del_p.ENSG345del|C9orf131_uc003zvx.2_In_Frame_Del_p.ENSG383del	NM_203299	NP_976044	Q5VYM1	CI131_HUMAN	hypothetical protein LOC138724 isoform A	418_421											0	all_epithelial(49;0.22)		LUSC - Lung squamous cell carcinoma(32;0.00117)|Lung(28;0.00309)			TGGGAATGCAGAGAAAACTCAGGAAACCTCTG	0.538			NA											10	101	---	---	---	---	NA	NA	NA	NA	NA
FUBP3	8939	broad.mit.edu	37	9	133485348	133485348	+	Frame_Shift_Del	DEL	C	C	-			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chr9:133485348delC	uc004bzr.1	+	3	306	c.198delC	c.(196-198)AACfs	p.N66fs	FUBP3_uc010mzd.1_Frame_Shift_Del_p.N6fs|FUBP3_uc004bzs.1_5'UTR	NM_003934	NP_003925	Q96I24	FUBP3_HUMAN	far upstream element (FUSE) binding protein 3	66					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|RNA binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(145;0.000279)		CAGTAGGTAACCAGTTAGGGG	0.378			NA											25	49	---	---	---	---	NA	NA	NA	NA	NA
FAM123B	139285	broad.mit.edu	37	X	63411772	63411772	+	Frame_Shift_Del	DEL	G	G	-			TCGA-99-7458-01A-11D-2036-08	TCGA-99-7458-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	6135f346-7be7-4beb-bc56-50a94e439776	d8bf0172-63f7-42c6-834d-dd3a53ee3f85	g.chrX:63411772delG	uc004dvo.2	-	2	1668	c.1395delC	c.(1393-1395)CCCfs	p.P465fs		NM_152424	NP_689637	Q5JTC6	F123B_HUMAN	family with sequence similarity 123B	465					Wnt receptor signaling pathway	cytoplasm|nucleus|plasma membrane		p.0?(40)		kidney(99)|large_intestine(6)|ovary(3)|lung(2)|breast(1)|liver(1)	112						CATCACTATTGGGGGCGGATT	0.547			NA											11	68	---	---	---	---	NA	NA	NA	NA	NA