Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	ACHILLES_Top_Genes	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
ZEB1	6935	broad.mit.edu	37	10	31810592	31810592	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7761-01A-11D-2167-08	TCGA-69-7761-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3986bd8-e8b0-4bcf-b850-abcbac67485f	e5f8e6d1-e696-4867-9857-6ef6b9a05262	g.chr10:31810592C>G	uc001ivs.3	+	7	2392	c.2329C>G	c.(2329-2331)CCA>GCA	p.P777A	ZEB1_uc001ivr.3_Missense_Mutation_p.P559A|ZEB1_uc010qee.1_Missense_Mutation_p.P559A|ZEB1_uc010qef.1_Missense_Mutation_p.P559A|ZEB1_uc009xlj.1_Missense_Mutation_p.P703A|ZEB1_uc010qeg.1_Missense_Mutation_p.P636A|ZEB1_uc009xlk.1_Missense_Mutation_p.P559A|ZEB1_uc001ivt.3_Missense_Mutation_p.P559A|ZEB1_uc001ivu.3_Missense_Mutation_p.P778A|ZEB1_uc001ivv.3_Missense_Mutation_p.P757A|ZEB1_uc010qeh.1_Missense_Mutation_p.P710A|ZEB1_uc009xlo.1_Missense_Mutation_p.P760A|ZEB1_uc009xlp.2_Missense_Mutation_p.P761A	NM_030751	NP_110378	P37275	ZEB1_HUMAN	zinc finger E-box binding homeobox 1 isoform b	777					cell proliferation|immune response|negative regulation of transcription from RNA polymerase II promoter|positive regulation of neuron differentiation	cytoplasm	E-box binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity|zinc ion binding			ovary(3)|central_nervous_system(2)	5		Prostate(175;0.0156)				AAAAAAGGAGCCACAAAAGGA	0.423	Ovarian(40;423 959 14296 36701 49589)		NA											12	53					0	0	0.013537	0	0
ANKRD30A	91074	broad.mit.edu	37	10	37431050	37431050	+	Missense_Mutation	SNP	G	G	C			TCGA-69-7761-01A-11D-2167-08	TCGA-69-7761-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3986bd8-e8b0-4bcf-b850-abcbac67485f	e5f8e6d1-e696-4867-9857-6ef6b9a05262	g.chr10:37431050G>C	uc001iza.1	+	7	1156	c.1057G>C	c.(1057-1059)GCA>CCA	p.A353P		NM_052997	NP_443723	Q9BXX3	AN30A_HUMAN	ankyrin repeat domain 30A	409						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(7)|breast(1)|skin(1)	9						ATTTACGTGGGCAGCAAAAGG	0.408			NA											3	34					0	0	0.009096	0	0
GLB1L3	112937	broad.mit.edu	37	11	134158730	134158730	+	Silent	SNP	G	G	A			TCGA-69-7761-01A-11D-2167-08	TCGA-69-7761-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3986bd8-e8b0-4bcf-b850-abcbac67485f	e5f8e6d1-e696-4867-9857-6ef6b9a05262	g.chr11:134158730G>A	uc009zdf.2	+	7	1035	c.675G>A	c.(673-675)GAG>GAA	p.E225E	GLB1L3_uc010scs.1_Silent_p.E225E|GLB1L3_uc010sct.1_Silent_p.E77E	NM_001080407	NP_001073876	Q8NCI6	GLBL3_HUMAN	galactosidase, beta 1 like 3	225					carbohydrate metabolic process		cation binding|hydrolase activity, hydrolyzing O-glycosyl compounds			pancreas(1)	1	all_hematologic(175;0.127)	all_cancers(12;5.52e-23)|all_epithelial(12;2.15e-16)|all_lung(97;1.19e-05)|Lung NSC(97;2.76e-05)|Breast(109;0.000162)|all_neural(223;0.0182)|Medulloblastoma(222;0.0208)|Esophageal squamous(93;0.0559)		Epithelial(10;1.3e-11)|all cancers(11;2.07e-10)|BRCA - Breast invasive adenocarcinoma(10;3.09e-10)|OV - Ovarian serous cystadenocarcinoma(99;0.000873)|Lung(977;0.222)		TGCAAGTGGAGAATGAGTATG	0.502			NA											5	26					0	0	0.02938	0	0
LOC100288778	100288778	broad.mit.edu	37	12	90862	90862	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7761-01A-11D-2167-08	TCGA-69-7761-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3986bd8-e8b0-4bcf-b850-abcbac67485f	e5f8e6d1-e696-4867-9857-6ef6b9a05262	g.chr12:90862C>T	uc010scy.1	+	10	1283	c.728C>T	c.(727-729)TCC>TTC	p.S243F	LOC100288778_uc010scz.1_RNA|LOC100288778_uc010sdd.1_3'UTR|LOC100288778_uc010sde.1_Missense_Mutation_p.S243F|LOC100288778_uc010sdf.1_Missense_Mutation_p.S243F|LOC100288778_uc010sdg.1_Missense_Mutation_p.S243F|LOC100288778_uc010sdh.1_RNA					SubName: Full=Actin nucleation promoting factor; Flags: Fragment;												0						GTGTCAGACTCCATCCCTCCT	0.647			NA											5	14					0	0	0.014758	0	0
KCNA5	3741	broad.mit.edu	37	12	5154827	5154827	+	Missense_Mutation	SNP	T	T	C			TCGA-69-7761-01A-11D-2167-08	TCGA-69-7761-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3986bd8-e8b0-4bcf-b850-abcbac67485f	e5f8e6d1-e696-4867-9857-6ef6b9a05262	g.chr12:5154827T>C	uc001qni.2	+	1	1743	c.1514T>C	c.(1513-1515)GTC>GCC	p.V505A		NM_002234	NP_002225	P22460	KCNA5_HUMAN	potassium voltage-gated channel, shaker-related	505	Helical; Name=Segment S6; (Potential).					Golgi apparatus|voltage-gated potassium channel complex	delayed rectifier potassium channel activity			ovary(2)|breast(2)	4						ATCGCCGGGGTCCTCACCATT	0.607			NA											8	59					0	0	0.008291	0	0
WBP11	51729	broad.mit.edu	37	12	14947586	14947586	+	Silent	SNP	A	A	G			TCGA-69-7761-01A-11D-2167-08	TCGA-69-7761-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3986bd8-e8b0-4bcf-b850-abcbac67485f	e5f8e6d1-e696-4867-9857-6ef6b9a05262	g.chr12:14947586A>G	uc001rci.2	-	7	767	c.606T>C	c.(604-606)CCT>CCC	p.P202P		NM_016312	NP_057396	Q9Y2W2	WBP11_HUMAN	WW domain binding protein 11	202	Pro-rich.				mRNA processing|RNA splicing|rRNA processing	cytoplasm	single-stranded DNA binding|WW domain binding			ovary(1)|lung(1)	2						GACCAGGGGGAGGGCCAGGAG	0.512			NA											4	114					0	0	0.009096	0	0
IL26	55801	broad.mit.edu	37	12	68619484	68619484	+	Missense_Mutation	SNP	A	A	T			TCGA-69-7761-01A-11D-2167-08	TCGA-69-7761-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3986bd8-e8b0-4bcf-b850-abcbac67485f	e5f8e6d1-e696-4867-9857-6ef6b9a05262	g.chr12:68619484A>T	uc001stx.1	-	1	88	c.53T>A	c.(52-54)CTT>CAT	p.L18H		NM_018402	NP_060872	Q9NPH9	IL26_HUMAN	interleukin 26 precursor	18					cell-cell signaling|negative regulation of epithelial cell proliferation|positive regulation of cytokine secretion|positive regulation of ERK1 and ERK2 cascade|positive regulation of JAK-STAT cascade|positive regulation of protein kinase B signaling cascade|positive regulation of stress-activated MAPK cascade|positive regulation of transcription from RNA polymerase II promoter	cytosol|extracellular space|soluble fraction	cytokine activity				0			Lung(24;0.000131)|LUAD - Lung adenocarcinoma(15;0.00107)|STAD - Stomach adenocarcinoma(21;0.018)	GBM - Glioblastoma multiforme(7;0.000515)		GGCAATGGCAAGAGACAGAGT	0.483			NA											25	96					0	0	0.030593	0	0
DRAM1	55332	broad.mit.edu	37	12	102315025	102315025	+	Missense_Mutation	SNP	A	A	G	rs61748066		TCGA-69-7761-01A-11D-2167-08	TCGA-69-7761-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3986bd8-e8b0-4bcf-b850-abcbac67485f	e5f8e6d1-e696-4867-9857-6ef6b9a05262	g.chr12:102315025A>G	uc001tix.2	+	7	1167	c.704A>G	c.(703-705)AAT>AGT	p.N235S	DRAM1_uc010svv.1_Missense_Mutation_p.N125S	NM_018370	NP_060840	Q8N682	DRAM1_HUMAN	DNA-damage regulated autophagy modulator 1	235					apoptosis|autophagy	integral to membrane|lysosomal membrane				ovary(1)	1						ACAGAAATCAATGGTGATATT	0.388			NA											14	76					0	0	0.043863	0	0
Unknown	0	broad.mit.edu	37	15	102294648	102294648	+	Missense_Mutation	SNP	T	T	C			TCGA-69-7761-01A-11D-2167-08	TCGA-69-7761-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3986bd8-e8b0-4bcf-b850-abcbac67485f	e5f8e6d1-e696-4867-9857-6ef6b9a05262	g.chr15:102294648T>C	uc010usj.1	+	5	535	c.476T>C	c.(475-477)CTG>CCG	p.L159P	uc002bxo.2_5'Flank|uc002bxq.2_5'Flank|uc002bxr.2_5'Flank|uc010usk.1_5'Flank|uc002bxs.2_5'Flank|uc002bxu.1_5'Flank|uc002bxv.1_5'Flank|uc002bxw.1_5'Flank|uc002bxy.1_5'Flank|uc002byb.1_5'Flank|uc002byd.2_5'Flank|uc002bye.2_5'Flank|uc002byf.1_5'Flank|uc002byg.2_5'Flank|uc002byi.2_5'Flank|uc002byk.2_5'Flank|uc002bym.2_5'Flank|uc002byn.2_5'Flank|uc010usm.1_5'Flank|uc002byr.2_5'Flank|uc002bys.2_5'Flank|uc002byv.2_5'Flank|uc002byx.3_5'Flank|uc002bza.2_5'Flank|uc002bzb.2_5'Flank|uc002bzc.1_5'Flank|uc002bzd.2_5'Flank|uc002bze.2_5'Flank|uc002bzg.2_5'Flank|uc002bzi.1_5'Flank|uc002bzj.2_5'Flank|uc002bzl.2_5'Flank|uc002bzm.2_5'Flank|uc002bzo.2_5'Flank|uc002bzp.2_5'Flank|uc002bzq.2_5'Flank					RecName: Full=Uncharacterized protein C15orf51.; Flags: Fragment;												NA						TTCTCAGAGCTGCTGTCCAAC	0.587			NA											4	34					0	0	0.021553	0	0
Unknown	0	broad.mit.edu	37	15	102294651	102294651	+	Missense_Mutation	SNP	T	T	G			TCGA-69-7761-01A-11D-2167-08	TCGA-69-7761-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3986bd8-e8b0-4bcf-b850-abcbac67485f	e5f8e6d1-e696-4867-9857-6ef6b9a05262	g.chr15:102294651T>G	uc010usj.1	+	5	538	c.479T>G	c.(478-480)CTG>CGG	p.L160R	uc002bxo.2_5'Flank|uc002bxq.2_5'Flank|uc002bxr.2_5'Flank|uc010usk.1_5'Flank|uc002bxs.2_5'Flank|uc002bxu.1_5'Flank|uc002bxv.1_5'Flank|uc002bxw.1_5'Flank|uc002bxy.1_5'Flank|uc002byb.1_5'Flank|uc002byd.2_5'Flank|uc002bye.2_5'Flank|uc002byf.1_5'Flank|uc002byg.2_5'Flank|uc002byi.2_5'Flank|uc002byk.2_5'Flank|uc002bym.2_5'Flank|uc002byn.2_5'Flank|uc010usm.1_5'Flank|uc002byr.2_5'Flank|uc002bys.2_5'Flank|uc002byv.2_5'Flank|uc002byx.3_5'Flank|uc002bza.2_5'Flank|uc002bzb.2_5'Flank|uc002bzc.1_5'Flank|uc002bzd.2_5'Flank|uc002bze.2_5'Flank|uc002bzg.2_5'Flank|uc002bzi.1_5'Flank|uc002bzj.2_5'Flank|uc002bzl.2_5'Flank|uc002bzm.2_5'Flank|uc002bzo.2_5'Flank|uc002bzp.2_5'Flank|uc002bzq.2_5'Flank					RecName: Full=Uncharacterized protein C15orf51.; Flags: Fragment;												NA						TCAGAGCTGCTGTCCAACCTG	0.587			NA											3	35					0	0	0.021553	0	0
GRIN2A	2903	broad.mit.edu	37	16	9943638	9943638	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7761-01A-11D-2167-08	TCGA-69-7761-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3986bd8-e8b0-4bcf-b850-abcbac67485f	e5f8e6d1-e696-4867-9857-6ef6b9a05262	g.chr16:9943638G>A	uc002czo.3	-	5	1851	c.1303C>T	c.(1303-1305)CCA>TCA	p.P435S	GRIN2A_uc010uym.1_Missense_Mutation_p.P435S|GRIN2A_uc010uyn.1_Missense_Mutation_p.P278S|GRIN2A_uc002czr.3_Missense_Mutation_p.P435S	NM_001134407	NP_001127879	Q12879	NMDE1_HUMAN	N-methyl-D-aspartate receptor subunit 2A isoform	435	Extracellular (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			skin(32)|NS(5)|ovary(4)|large_intestine(1)|lung(1)|breast(1)|kidney(1)	45					Felbamate(DB00949)|Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	TTCCGACATGGCACGGTGTTC	0.512			NA											3	115					0	0	0.004672	0	0
SKA1	220134	broad.mit.edu	37	18	47911673	47911673	+	Missense_Mutation	SNP	T	T	A			TCGA-69-7761-01A-11D-2167-08	TCGA-69-7761-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3986bd8-e8b0-4bcf-b850-abcbac67485f	e5f8e6d1-e696-4867-9857-6ef6b9a05262	g.chr18:47911673T>A	uc002let.2	+	5	583	c.399T>A	c.(397-399)AGT>AGA	p.S133R	SKA1_uc002leu.2_Missense_Mutation_p.S133R|SKA1_uc010xdl.1_Intron	NM_145060	NP_659497	Q96BD8	SKA1_HUMAN	spindle and KT associated 1	133					cell division|chromosome segregation|mitotic anaphase|mitotic prometaphase|regulation of microtubule polymerization or depolymerization	condensed chromosome outer kinetochore|cytosol|spindle microtubule	microtubule binding				0						AGCAAAGAAGTATTAAGGAAA	0.348			NA											3	29					0	0	0.009096	0	0
ZNF208	7757	broad.mit.edu	37	19	22155850	22155850	+	Silent	SNP	C	C	T			TCGA-69-7761-01A-11D-2167-08	TCGA-69-7761-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3986bd8-e8b0-4bcf-b850-abcbac67485f	e5f8e6d1-e696-4867-9857-6ef6b9a05262	g.chr19:22155850C>T	uc002nqp.2	-	5	1835	c.1686G>A	c.(1684-1686)GAG>GAA	p.E562E	ZNF208_uc002nqo.1_Intron	NM_007153	NP_009084			zinc finger protein 208											ovary(5)|skin(2)	7		all_lung(12;0.0961)|Lung NSC(12;0.103)				TGTAGGGCTTCTCTCCAGCAT	0.383			NA											4	42					0	0	0.009096	0	0
ZNF208	7757	broad.mit.edu	37	19	22155934	22155934	+	Silent	SNP	C	C	T			TCGA-69-7761-01A-11D-2167-08	TCGA-69-7761-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3986bd8-e8b0-4bcf-b850-abcbac67485f	e5f8e6d1-e696-4867-9857-6ef6b9a05262	g.chr19:22155934C>T	uc002nqp.2	-	5	1751	c.1602G>A	c.(1600-1602)GAG>GAA	p.E534E	ZNF208_uc002nqo.1_Intron	NM_007153	NP_009084			zinc finger protein 208											ovary(5)|skin(2)	7		all_lung(12;0.0961)|Lung NSC(12;0.103)				TGTAGGGCTTCTCTCCAGCAT	0.398			NA											3	69					0	0	0.009096	0	0
DPF1	8193	broad.mit.edu	37	19	38704349	38704349	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7761-01A-11D-2167-08	TCGA-69-7761-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3986bd8-e8b0-4bcf-b850-abcbac67485f	e5f8e6d1-e696-4867-9857-6ef6b9a05262	g.chr19:38704349G>A	uc002ohl.2	-	9	922	c.895C>T	c.(895-897)CGG>TGG	p.R299W	DPF1_uc002ohm.2_Missense_Mutation_p.R343W|DPF1_uc002ohn.2_Missense_Mutation_p.R261W|DPF1_uc010xtu.1_Missense_Mutation_p.R317W|DPF1_uc010xtv.1_Missense_Mutation_p.R317W	NM_004647	NP_004638	Q92782	DPF1_HUMAN	D4, zinc and double PHD fingers family 1 isoform	299	PHD-type 1.				induction of apoptosis|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nBAF complex	zinc ion binding				0	all_cancers(60;1.24e-06)		Lung(45;0.000246)|LUSC - Lung squamous cell carcinoma(53;0.000292)			CGGTAGGTCCGCACGGCTGCC	0.667			NA											3	103					0	0	0.004672	0	0
PSG8	440533	broad.mit.edu	37	19	43258606	43258606	+	Silent	SNP	T	T	A			TCGA-69-7761-01A-11D-2167-08	TCGA-69-7761-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3986bd8-e8b0-4bcf-b850-abcbac67485f	e5f8e6d1-e696-4867-9857-6ef6b9a05262	g.chr19:43258606T>A	uc002ouo.2	-	5	1220	c.1122A>T	c.(1120-1122)CTA>CTT	p.L374L	PSG3_uc002ouf.2_Intron|PSG1_uc002oug.1_Intron|PSG8_uc010eim.2_RNA|PSG8_uc002oui.2_Silent_p.L213L|PSG8_uc002ouh.2_Silent_p.L374L|PSG8_uc010ein.2_Silent_p.L252L|PSG8_uc002ouj.3_Silent_p.L156L|PSG8_uc002ouk.3_Silent_p.L213L|PSG8_uc002oul.3_Silent_p.L374L|PSG8_uc002oum.3_Silent_p.L281L|PSG1_uc002oun.2_Intron|PSG8_uc002oup.3_Silent_p.L281L	NM_182707	NP_874366	Q9UQ74	PSG8_HUMAN	pregnancy specific beta-1-glycoprotein 8 isoform	374	Ig-like C2-type 3.					extracellular region					0		Prostate(69;0.00899)				TTTGTCCTGATAGCTGAAACT	0.463			NA											21	212					0	0	0.030593	0	0
PTH2	113091	broad.mit.edu	37	19	49926533	49926533	+	Missense_Mutation	SNP	G	G	C			TCGA-69-7761-01A-11D-2167-08	TCGA-69-7761-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3986bd8-e8b0-4bcf-b850-abcbac67485f	e5f8e6d1-e696-4867-9857-6ef6b9a05262	g.chr19:49926533G>C	uc002pnn.1	-	1	166	c.64C>G	c.(64-66)CTG>GTG	p.L22V		NM_178449	NP_848544	Q96A98	TIP39_HUMAN	parathyroid hormone 2 preproprotein	22					neuropeptide signaling pathway	extracellular region					0				OV - Ovarian serous cystadenocarcinoma(262;0.0015)|GBM - Glioblastoma multiforme(486;0.044)|Lung(386;0.0785)|LUSC - Lung squamous cell carcinoma(496;0.0836)		GGCACCACcagcagcagcagc	0.597			NA											3	25					0	0	0.009096	0	0
ID2	3398	broad.mit.edu	37	2	8822342	8822342	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7761-01A-11D-2167-08	TCGA-69-7761-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3986bd8-e8b0-4bcf-b850-abcbac67485f	e5f8e6d1-e696-4867-9857-6ef6b9a05262	g.chr2:8822342C>T	uc010yiu.1	+	3	542	c.47C>T	c.(46-48)TCG>TTG	p.S16L	ID2_uc002qza.2_Missense_Mutation_p.S16L	NM_002166	NP_002157	Q02363	ID2_HUMAN	inhibitor of DNA binding 2	16					cellular senescence|embryonic digestive tract morphogenesis|endodermal digestive tract morphogenesis|epithelial cell differentiation involved in mammary gland alveolus development|mammary gland epithelial cell proliferation|negative regulation of neural precursor cell proliferation|negative regulation of neuron differentiation|negative regulation of sequence-specific DNA binding transcription factor activity|neuron fate commitment|positive regulation of blood pressure|positive regulation of cell cycle arrest|positive regulation of smooth muscle cell proliferation|positive regulation of transcription, DNA-dependent	protein complex	protein binding				0	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)					AACAGCCTGTCGGACCACAGC	0.597			NA											5	39					0	0	0.02938	0	0
TTN	7273	broad.mit.edu	37	2	179592542	179592542	+	Missense_Mutation	SNP	T	T	A			TCGA-69-7761-01A-11D-2167-08	TCGA-69-7761-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3986bd8-e8b0-4bcf-b850-abcbac67485f	e5f8e6d1-e696-4867-9857-6ef6b9a05262	g.chr2:179592542T>A	uc010zfg.1	-	65	16255	c.16031A>T	c.(16030-16032)GAT>GTT	p.D5344V	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.D2005V	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	6271							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CACTGTAGAATCAGGTATGGC	0.353			NA											8	22					0	0	0.006214	0	0
RALGAPA2	57186	broad.mit.edu	37	20	20600000	20600000	+	Missense_Mutation	SNP	A	A	C			TCGA-69-7761-01A-11D-2167-08	TCGA-69-7761-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3986bd8-e8b0-4bcf-b850-abcbac67485f	e5f8e6d1-e696-4867-9857-6ef6b9a05262	g.chr20:20600000A>C	uc002wrz.2	-	12	1603	c.1460T>G	c.(1459-1461)TTC>TGC	p.F487C	RALGAPA2_uc010gcx.2_Missense_Mutation_p.F191C|RALGAPA2_uc010zsg.1_5'UTR	NM_020343	NP_065076	Q2PPJ7	RGPA2_HUMAN	akt substrate AS250	487					activation of Ral GTPase activity	cytosol|nucleus	protein heterodimerization activity|Ral GTPase activator activity			ovary(1)	1						TGCACTTGTGAAGGAGTATGT	0.483			NA											3	13					0	0	0.004672	0	0
MYT1	4661	broad.mit.edu	37	20	62839705	62839705	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7761-01A-11D-2167-08	TCGA-69-7761-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3986bd8-e8b0-4bcf-b850-abcbac67485f	e5f8e6d1-e696-4867-9857-6ef6b9a05262	g.chr20:62839705G>A	uc002yii.2	+	7	1520	c.1156G>A	c.(1156-1158)GCC>ACC	p.A386T	MYT1_uc002yih.2_Intron|MYT1_uc002yij.2_Missense_Mutation_p.A18T	NM_004535	NP_004526	Q01538	MYT1_HUMAN	myelin transcription factor 1	386					cell differentiation|nervous system development	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2	all_cancers(38;1.82e-11)|all_epithelial(29;3.3e-13)|Lung NSC(23;5.21e-10)|all_lung(23;1.92e-09)					GCAGGCCATCGCCCTGAAGGC	0.662	GBM(59;481 1041 20555 21139 33705)		NA											9	32					0	0	0.016723	0	0
ITSN1	6453	broad.mit.edu	37	21	35147397	35147397	+	Silent	SNP	A	A	G			TCGA-69-7761-01A-11D-2167-08	TCGA-69-7761-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3986bd8-e8b0-4bcf-b850-abcbac67485f	e5f8e6d1-e696-4867-9857-6ef6b9a05262	g.chr21:35147397A>G	uc002yta.1	+	14	1849	c.1581A>G	c.(1579-1581)CTA>CTG	p.L527L	DONSON_uc002ysn.1_Intron|ITSN1_uc002yth.3_RNA|ITSN1_uc002ysz.2_Silent_p.L527L|ITSN1_uc010gmg.2_Silent_p.L490L|ITSN1_uc010gmh.2_RNA|ITSN1_uc002ysw.2_Silent_p.L527L|ITSN1_uc010gmi.2_Silent_p.L490L|ITSN1_uc010gmj.2_Silent_p.L411L|ITSN1_uc002ysy.2_Silent_p.L527L|ITSN1_uc002ysx.2_Silent_p.L490L|ITSN1_uc002ytb.1_Silent_p.L527L|ITSN1_uc002ytc.1_Silent_p.L527L|ITSN1_uc002ytd.2_RNA|ITSN1_uc010gmk.2_Silent_p.L490L|ITSN1_uc010gml.2_RNA|ITSN1_uc002ytj.2_Silent_p.L527L|ITSN1_uc010gmm.1_RNA|ITSN1_uc002yte.2_Silent_p.L461L	NM_003024	NP_003015	Q15811	ITSN1_HUMAN	intersectin 1 isoform ITSN-l	527	Potential.|KLERQ.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|synaptic vesicle endocytosis	cell junction|coated pit|cytosol|lamellipodium|synapse|synaptosome	calcium ion binding|proline-rich region binding|protein complex scaffold|Rho guanyl-nucleotide exchange factor activity			ovary(3)|skin(1)	4						TCACCCATCTACAGCAACAAT	0.333			NA											6	34					0	0	0.02938	0	0
RRP1	8568	broad.mit.edu	37	21	45220445	45220445	+	Silent	SNP	C	C	T			TCGA-69-7761-01A-11D-2167-08	TCGA-69-7761-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3986bd8-e8b0-4bcf-b850-abcbac67485f	e5f8e6d1-e696-4867-9857-6ef6b9a05262	g.chr21:45220445C>T	uc002zds.2	+	10	1032	c.939C>T	c.(937-939)CGC>CGT	p.R313R	RRP1_uc011aez.1_Silent_p.R313R|RRP1_uc010gpk.1_Silent_p.R163R|RRP1_uc010gpl.1_Silent_p.R211R|RRP1_uc010gpm.1_Silent_p.R180R	NM_003683	NP_003674	P56182	RRP1_HUMAN	ribosomal RNA processing 1 homolog	313					rRNA processing	nucleolus|preribosome, small subunit precursor					0				COAD - Colon adenocarcinoma(84;0.00753)|Colorectal(79;0.0157)|STAD - Stomach adenocarcinoma(101;0.171)		TGGCCAGCCGCCAGAGCACCC	0.552			NA											4	24					0	0	0.014758	0	0
ZNF74	7625	broad.mit.edu	37	22	20760303	20760303	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7761-01A-11D-2167-08	TCGA-69-7761-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3986bd8-e8b0-4bcf-b850-abcbac67485f	e5f8e6d1-e696-4867-9857-6ef6b9a05262	g.chr22:20760303C>T	uc010gsm.2	+	6	1192	c.980C>T	c.(979-981)ACG>ATG	p.T327M	ZNF74_uc002zsg.2_Missense_Mutation_p.T256M|ZNF74_uc002zsh.2_Missense_Mutation_p.T327M|ZNF74_uc002zsi.2_Missense_Mutation_p.T256M|ZNF74_uc010gsn.2_Missense_Mutation_p.T256M	NM_003426	NP_003417	Q16587	ZNF74_HUMAN	zinc finger protein 74	327					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	actin cytoskeleton|nucleus	DNA binding|RNA binding|zinc ion binding			ovary(1)	1	Melanoma(16;0.000465)|Ovarian(15;0.0025)|Colorectal(54;0.0221)|all_neural(72;0.219)	Lung SC(17;0.0262)|all_lung(157;0.248)	LUSC - Lung squamous cell carcinoma(15;0.00102)|Lung(15;0.0173)			CGCATCCACACGGGCGAGCGG	0.672			NA											7	38					0	0	0.038147	0	0
SCN10A	6336	broad.mit.edu	37	3	38798590	38798590	+	Silent	SNP	G	G	C			TCGA-69-7761-01A-11D-2167-08	TCGA-69-7761-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3986bd8-e8b0-4bcf-b850-abcbac67485f	e5f8e6d1-e696-4867-9857-6ef6b9a05262	g.chr3:38798590G>C	uc003ciq.2	-	8	1011	c.1011C>G	c.(1009-1011)ACC>ACG	p.T337T		NM_006514	NP_006505	Q9Y5Y9	SCNAA_HUMAN	sodium channel, voltage-gated, type X, alpha	337	I.				sensory perception	voltage-gated sodium channel complex				ovary(5)|skin(3)|large_intestine(1)|kidney(1)	10				KIRC - Kidney renal clear cell carcinoma(284;0.0769)|Kidney(284;0.0945)	Benzocaine(DB01086)|Bupivacaine(DB00297)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dibucaine(DB00527)|Dyclonine(DB00645)|Hexylcaine(DB00473)|Levobupivacaine(DB01002)|Lidocaine(DB00281)|Mepivacaine(DB00961)|Oxybuprocaine(DB00892)|Procaine(DB00721)|Proparacaine(DB00807)|Ropivacaine(DB00296)	AATCAAAGCTGGTGTAGTTAA	0.498			NA											9	39					0	0	0.008291	0	0
PLXNB1	5364	broad.mit.edu	37	3	48454284	48454284	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7761-01A-11D-2167-08	TCGA-69-7761-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3986bd8-e8b0-4bcf-b850-abcbac67485f	e5f8e6d1-e696-4867-9857-6ef6b9a05262	g.chr3:48454284C>G	uc003csw.2	-	25	4991	c.4721G>C	c.(4720-4722)AGG>ACG	p.R1574T	PLXNB1_uc003cst.2_Missense_Mutation_p.R24T|PLXNB1_uc003csu.2_Missense_Mutation_p.R1391T|PLXNB1_uc003csx.2_Missense_Mutation_p.R1574T	NM_002673	NP_002664	O43157	PLXB1_HUMAN	plexin B1 precursor	1574	Cytoplasmic (Potential).				axon guidance|cell migration|intracellular signal transduction|regulation of cell shape|regulation of cytoskeleton organization|regulation of small GTPase mediated signal transduction|semaphorin-plexin signaling pathway	extracellular region|integral to plasma membrane|intracellular|semaphorin receptor complex	GTPase activator activity|semaphorin receptor activity|semaphorin receptor binding			ovary(2)|pancreas(1)|breast(1)|skin(1)	5				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		GAAGAAGATCCTCTCCGCATA	0.612			NA											8	71					0	0	0.004482	0	0
FRYL	285527	broad.mit.edu	37	4	48622705	48622705	+	Nonsense_Mutation	SNP	C	C	A			TCGA-69-7761-01A-11D-2167-08	TCGA-69-7761-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3986bd8-e8b0-4bcf-b850-abcbac67485f	e5f8e6d1-e696-4867-9857-6ef6b9a05262	g.chr4:48622705C>A	uc003gyh.1	-	6	870	c.265G>T	c.(265-267)GAA>TAA	p.E89*	FRYL_uc003gyk.2_Nonsense_Mutation_p.E89*|FRYL_uc003gyl.1_Nonsense_Mutation_p.E140*|FRYL_uc003gym.1_Nonsense_Mutation_p.E89*	NM_015030	NP_055845	O94915	FRYL_HUMAN	furry-like	89					regulation of transcription, DNA-dependent|transcription, DNA-dependent		protein binding			skin(1)	1						GATTCATCTTCCGTTCCATTT	0.428			NA											7	74					1.12685e-05	1.2771e-05	0.004482	1	0
ALPK1	80216	broad.mit.edu	37	4	113356393	113356393	+	Nonsense_Mutation	SNP	A	A	T			TCGA-69-7761-01A-11D-2167-08	TCGA-69-7761-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3986bd8-e8b0-4bcf-b850-abcbac67485f	e5f8e6d1-e696-4867-9857-6ef6b9a05262	g.chr4:113356393A>T	uc003iap.3	+	12	3403	c.3124A>T	c.(3124-3126)AAA>TAA	p.K1042*	ALPK1_uc003ian.3_Nonsense_Mutation_p.K1042*|ALPK1_uc011cfx.1_Nonsense_Mutation_p.K964*|ALPK1_uc003iao.3_RNA|ALPK1_uc010imo.2_Nonsense_Mutation_p.K870*	NM_025144	NP_079420	Q96QP1	ALPK1_HUMAN	alpha-kinase 1	1042	Alpha-type protein kinase.						ATP binding|protein serine/threonine kinase activity			ovary(5)	5		Ovarian(17;0.0446)|Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.00325)		GACTGTGAAGAAAAAAGGCAG	0.348			NA											11	111					0	0	0.020292	0	0
ZFYVE16	9765	broad.mit.edu	37	5	79733547	79733547	+	Missense_Mutation	SNP	G	G	C			TCGA-69-7761-01A-11D-2167-08	TCGA-69-7761-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3986bd8-e8b0-4bcf-b850-abcbac67485f	e5f8e6d1-e696-4867-9857-6ef6b9a05262	g.chr5:79733547G>C	uc003kgr.3	+	4	1345	c.1043G>C	c.(1042-1044)AGT>ACT	p.S348T	ZFYVE16_uc010jak.1_Missense_Mutation_p.S348T|ZFYVE16_uc003kgp.2_Missense_Mutation_p.S348T|ZFYVE16_uc003kgq.3_Missense_Mutation_p.S348T|ZFYVE16_uc003kgs.3_Missense_Mutation_p.S348T	NM_001105251	NP_001098721	Q7Z3T8	ZFY16_HUMAN	zinc finger, FYVE domain containing 16	348					BMP signaling pathway|endosome transport|protein targeting to lysosome|regulation of endocytosis|vesicle organization	early endosome membrane	1-phosphatidylinositol binding|metal ion binding|phosphatidylinositol-3,4,5-trisphosphate binding|protein binding|protein transporter activity				0		Lung NSC(167;0.00428)|all_lung(232;0.00455)|Ovarian(174;0.0261)		OV - Ovarian serous cystadenocarcinoma(54;1.6e-46)|Epithelial(54;2.02e-41)|all cancers(79;5.05e-36)		GACTCAAAAAGTTTAGACCTT	0.353	Melanoma(150;1452 1854 16018 17851 37292)		NA											10	27					0	0	0.010729	0	0
PCDHB15	56121	broad.mit.edu	37	5	140625619	140625619	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7761-01A-11D-2167-08	TCGA-69-7761-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3986bd8-e8b0-4bcf-b850-abcbac67485f	e5f8e6d1-e696-4867-9857-6ef6b9a05262	g.chr5:140625619G>A	uc003lje.2	+	1	473	c.473G>A	c.(472-474)CGG>CAG	p.R158Q		NM_018935	NP_061758	Q9Y5E8	PCDBF_HUMAN	protocadherin beta 15 precursor	158	Extracellular (Potential).|Cadherin 2.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			ovary(2)|breast(2)|skin(1)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			AAAAAAGCTCGGGACTTGGAC	0.448			NA											3	38					0	0	0.009096	0	0
BTN2A2	10385	broad.mit.edu	37	6	26384103	26384103	+	Silent	SNP	C	C	G			TCGA-69-7761-01A-11D-2167-08	TCGA-69-7761-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3986bd8-e8b0-4bcf-b850-abcbac67485f	e5f8e6d1-e696-4867-9857-6ef6b9a05262	g.chr6:26384103C>G	uc003nhq.2	+	2	140	c.54C>G	c.(52-54)CTC>CTG	p.L18L	BTN2A2_uc011dkf.1_Silent_p.L18L|BTN2A2_uc011dkg.1_Silent_p.L18L|BTN2A2_uc003nhr.2_Silent_p.L18L|BTN2A2_uc011dkh.1_Silent_p.L18L|BTN2A2_uc003nhs.2_Silent_p.L18L|BTN2A2_uc003nht.2_Silent_p.L18L	NM_006995	NP_008926	Q8WVV5	BT2A2_HUMAN	butyrophilin, subfamily 2, member A2 isoform a	18					negative regulation of activated T cell proliferation|negative regulation of cellular metabolic process|negative regulation of cytokine secretion	integral to membrane					0						tcctcctcctcctgctcctcc	0.488			NA											3	70					0	0	0.009096	0	0
CD109	135228	broad.mit.edu	37	6	74497176	74497176	+	Splice_Site	SNP	G	G	T			TCGA-69-7761-01A-11D-2167-08	TCGA-69-7761-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3986bd8-e8b0-4bcf-b850-abcbac67485f	e5f8e6d1-e696-4867-9857-6ef6b9a05262	g.chr6:74497176G>T	uc003php.2	+	21	2981	c.2556_splice	c.e21+1	p.K852_splice	CD109_uc010kaz.2_Intron|CD109_uc003phq.2_Splice_Site_p.K852_splice|CD109_uc010kba.2_Splice_Site_p.K775_splice	NM_133493	NP_598000	Q6YHK3	CD109_HUMAN	CD109 antigen isoform 1 precursor							anchored to membrane|extracellular space|plasma membrane	serine-type endopeptidase inhibitor activity			large_intestine(2)|ovary(2)	4						TTTAGTAAAGGTAAATATTTG	0.378			NA											10	30					3.03607e-14	3.51908e-14	0.013537	1	0
PCLO	27445	broad.mit.edu	37	7	82763935	82763935	+	Missense_Mutation	SNP	T	T	G			TCGA-69-7761-01A-11D-2167-08	TCGA-69-7761-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3986bd8-e8b0-4bcf-b850-abcbac67485f	e5f8e6d1-e696-4867-9857-6ef6b9a05262	g.chr7:82763935T>G	uc003uhx.2	-	3	3220	c.2931A>C	c.(2929-2931)CAA>CAC	p.Q977H	PCLO_uc003uhv.2_Missense_Mutation_p.Q977H	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	923	Pro-rich.				cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						TGGGTGGCCCTTGTGAAGTAG	0.507			NA											4	14					0	0	0.014758	0	0
DPYSL2	1808	broad.mit.edu	37	8	26441458	26441458	+	Missense_Mutation	SNP	A	A	G	rs113269672		TCGA-69-7761-01A-11D-2167-08	TCGA-69-7761-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3986bd8-e8b0-4bcf-b850-abcbac67485f	e5f8e6d1-e696-4867-9857-6ef6b9a05262	g.chr8:26441458A>G	uc003xfb.1	+	3	622	c.272A>G	c.(271-273)CAA>CGA	p.Q91R	DPYSL2_uc003xfa.2_Missense_Mutation_p.Q196R|DPYSL2_uc011lag.1_Missense_Mutation_p.Q91R|DPYSL2_uc010luk.1_RNA|DPYSL2_uc011lah.1_Missense_Mutation_p.Q55R	NM_001386	NP_001377	Q16555	DPYL2_HUMAN	dihydropyrimidinase-like 2	91					axon guidance|pyrimidine base catabolic process|signal transduction	cytosol	dihydropyrimidinase activity|protein binding			large_intestine(1)	1		all_cancers(63;0.121)|Ovarian(32;2.68e-05)|all_epithelial(46;0.116)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0228)|Epithelial(17;3.33e-10)|Colorectal(74;0.183)		GATTTCTTCCAAGGAACCAAG	0.498			NA											18	84					0	0	0.01892	0	0
ARFGEF1	10565	broad.mit.edu	37	8	68140474	68140474	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7761-01A-11D-2167-08	TCGA-69-7761-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3986bd8-e8b0-4bcf-b850-abcbac67485f	e5f8e6d1-e696-4867-9857-6ef6b9a05262	g.chr8:68140474C>A	uc003xxo.1	-	24	3796	c.3406G>T	c.(3406-3408)GAT>TAT	p.D1136Y	ARFGEF1_uc003xxl.1_Missense_Mutation_p.D590Y|ARFGEF1_uc003xxn.1_Missense_Mutation_p.D119Y	NM_006421	NP_006412	Q9Y6D6	BIG1_HUMAN	brefeldin A-inhibited guanine	1136					exocytosis|regulation of ARF protein signal transduction	cytoplasm	ARF guanyl-nucleotide exchange factor activity|myosin binding			ovary(4)|upper_aerodigestive_tract(1)|large_intestine(1)|lung(1)|kidney(1)	8	Breast(64;0.214)	Lung NSC(129;0.0908)|all_lung(136;0.152)	Epithelial(68;0.0043)|OV - Ovarian serous cystadenocarcinoma(28;0.00578)|all cancers(69;0.0173)|BRCA - Breast invasive adenocarcinoma(89;0.206)			GCATTTCCATCTAGCCTTGTA	0.308			NA											9	102					0.00829132	0.00919255	0.008291	1	0
TOP1MT	116447	broad.mit.edu	37	8	144406735	144406735	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7761-01A-11D-2167-08	TCGA-69-7761-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3986bd8-e8b0-4bcf-b850-abcbac67485f	e5f8e6d1-e696-4867-9857-6ef6b9a05262	g.chr8:144406735C>T	uc003yxz.2	-	6	755	c.736G>A	c.(736-738)GTC>ATC	p.V246I	TOP1MT_uc011lkd.1_Missense_Mutation_p.V148I|TOP1MT_uc011lke.1_Missense_Mutation_p.V148I|TOP1MT_uc010mfb.2_Missense_Mutation_p.V148I|TOP1MT_uc011lkf.1_Missense_Mutation_p.V41I|TOP1MT_uc010mfd.1_Missense_Mutation_p.V41I	NM_052963	NP_443195	Q969P6	TOP1M_HUMAN	mitochondrial topoisomerase I precursor	246					DNA topological change	chromosome|mitochondrial nucleoid	ATP binding|chromatin DNA binding|DNA topoisomerase (ATP-hydrolyzing) activity|DNA topoisomerase type I activity			ovary(1)	1	all_cancers(97;1.01e-10)|all_epithelial(106;4.86e-09)|Lung NSC(106;0.000167)|all_lung(105;0.000459)|Ovarian(258;0.0212)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.156)|Colorectal(110;0.173)		Irinotecan(DB00762)|Topotecan(DB01030)	AGCCACGTGACGGTGTTATCG	0.592			NA											6	113					0	0	0.021553	0	0
ARHGEF9	23229	broad.mit.edu	37	X	62944546	62944546	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7761-01A-11D-2167-08	TCGA-69-7761-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3986bd8-e8b0-4bcf-b850-abcbac67485f	e5f8e6d1-e696-4867-9857-6ef6b9a05262	g.chrX:62944546G>A	uc004dvl.2	-	2	894	c.55C>T	c.(55-57)CAC>TAC	p.H19Y	ARHGEF9_uc004dvj.1_Intron|ARHGEF9_uc004dvk.1_5'UTR|ARHGEF9_uc011mos.1_5'UTR|ARHGEF9_uc004dvm.1_5'UTR|ARHGEF9_uc011mot.1_Intron|ARHGEF9_uc004dvn.2_Missense_Mutation_p.H26Y	NM_015185	NP_056000	O43307	ARHG9_HUMAN	Cdc42 guanine exchange factor 9	19	SH3.				apoptosis|induction of apoptosis by extracellular signals|ion transmembrane transport|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|synaptic transmission	cytosol	Rho guanyl-nucleotide exchange factor activity			ovary(5)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	8						ATGGTGACGTGATCCCATACT	0.512			NA											3	38					0	0	0.009096	0	0
OGT	8473	broad.mit.edu	37	X	70775057	70775057	+	Missense_Mutation	SNP	T	T	A			TCGA-69-7761-01A-11D-2167-08	TCGA-69-7761-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3986bd8-e8b0-4bcf-b850-abcbac67485f	e5f8e6d1-e696-4867-9857-6ef6b9a05262	g.chrX:70775057T>A	uc004eaa.1	+	7	963	c.746T>A	c.(745-747)CTT>CAT	p.L249H	BCYRN1_uc011mpt.1_Intron|OGT_uc004eab.1_Missense_Mutation_p.L239H|OGT_uc004eac.2_Missense_Mutation_p.L110H|OGT_uc004ead.2_Intron	NM_181672	NP_858058	O15294	OGT1_HUMAN	O-linked GlcNAc transferase isoform 1	249	TPR 6.				cellular response to retinoic acid|positive regulation of granulocyte differentiation|positive regulation of histone H3-K4 methylation|positive regulation of proteolysis|protein O-linked glycosylation|signal transduction	cytosol|MLL5-L complex	enzyme activator activity|protein binding|protein N-acetylglucosaminyltransferase activity			ovary(3)|kidney(1)|pancreas(1)	5	Renal(35;0.156)					GCAGCTTATCTTCGTGCCCTA	0.348			NA											3	16					0	0	0.004672	0	0
LRRIQ1	84125	broad.mit.edu	37	12	85449409	85449409	+	Frame_Shift_Del	DEL	T	T	-			TCGA-69-7761-01A-11D-2167-08	TCGA-69-7761-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3986bd8-e8b0-4bcf-b850-abcbac67485f	e5f8e6d1-e696-4867-9857-6ef6b9a05262	g.chr12:85449409delT	uc001tac.2	+	8	949	c.838delT	c.(838-840)TTAfs	p.L280fs	LRRIQ1_uc001tab.1_Frame_Shift_Del_p.L280fs|LRRIQ1_uc001taa.1_Frame_Shift_Del_p.L255fs	NM_001079910	NP_001073379	Q96JM4	LRIQ1_HUMAN	leucine-rich repeats and IQ motif containing 1	280	Glu-rich.									ovary(4)|central_nervous_system(1)|skin(1)	6				GBM - Glioblastoma multiforme(134;0.212)		AAATTCTTTGTTAAAACAGCA	0.274			NA											7	21	---	---	---	---	NA	NA	NA	NA	NA
ITGB4	3691	broad.mit.edu	37	17	73732157	73732158	+	Frame_Shift_Del	DEL	GT	GT	-	rs121912463		TCGA-69-7761-01A-11D-2167-08	TCGA-69-7761-10A-01D-2167-08	GT	GT	-	-	GT	GT	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3986bd8-e8b0-4bcf-b850-abcbac67485f	e5f8e6d1-e696-4867-9857-6ef6b9a05262	g.chr17:73732157_73732158delGT	uc002jpg.2	+	14	1870_1871	c.1683_1684delGT	c.(1681-1686)CAGTGTfs	p.Q561fs	ITGB4_uc002jph.2_Frame_Shift_Del_p.Q561fs|ITGB4_uc010dgo.2_Frame_Shift_Del_p.Q561fs|ITGB4_uc002jpi.3_Frame_Shift_Del_p.Q561fs|ITGB4_uc010dgp.1_Frame_Shift_Del_p.Q561fs|ITGB4_uc002jpj.2_Frame_Shift_Del_p.Q561fs|ITGB4_uc010wsh.1_Frame_Shift_Del_p.Q116fs	NM_000213	NP_000204	P16144	ITB4_HUMAN	integrin beta 4 isoform 1 precursor	561_562	III.|Extracellular (Potential).|Cysteine-rich tandem repeats.		C -> R (in EB-PA; mild form).		cell communication|cell motility|cell-matrix adhesion|hemidesmosome assembly|integrin-mediated signaling pathway|multicellular organismal development|response to wounding	cell leading edge|cell surface|hemidesmosome|integrin complex	protein binding|receptor activity			lung(4)	4	all_cancers(13;1.5e-07)		all cancers(21;8.32e-07)|Epithelial(20;1.92e-06)|BRCA - Breast invasive adenocarcinoma(9;0.00194)|Lung(188;0.132)|LUSC - Lung squamous cell carcinoma(166;0.154)			CCATGGGCCAGTGTGTGTGTGA	0.604			NA											7	260	---	---	---	---	NA	NA	NA	NA	NA
ANKRD44	91526	broad.mit.edu	37	2	197943383	197943384	+	Frame_Shift_Del	DEL	TG	TG	-			TCGA-69-7761-01A-11D-2167-08	TCGA-69-7761-10A-01D-2167-08	TG	TG	-	-	TG	TG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3986bd8-e8b0-4bcf-b850-abcbac67485f	e5f8e6d1-e696-4867-9857-6ef6b9a05262	g.chr2:197943383_197943384delTG	uc002uub.2	-	16	1860_1861	c.1693_1694delCA	c.(1693-1695)CATfs	p.H565fs	ANKRD44_uc002utz.3_Intron|ANKRD44_uc002uua.1_Intron|ANKRD44_uc010zgw.1_Frame_Shift_Del_p.H493fs	NM_153697	NP_710181	Q8N8A2	ANR44_HUMAN	ankyrin repeat domain 44	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment							protein binding			ovary(4)|skin(1)	5			OV - Ovarian serous cystadenocarcinoma(117;0.246)			ATTTGGGGTATGTGTGTGTGTG	0.342			NA											4	6	---	---	---	---	NA	NA	NA	NA	NA
GLT8D1	55830	broad.mit.edu	37	3	52730605	52730609	+	Frame_Shift_Del	DEL	CCAAA	CCAAA	-			TCGA-69-7761-01A-11D-2167-08	TCGA-69-7761-10A-01D-2167-08	CCAAA	CCAAA	-	-	CCAAA	CCAAA	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3986bd8-e8b0-4bcf-b850-abcbac67485f	e5f8e6d1-e696-4867-9857-6ef6b9a05262	g.chr3:52730605_52730609delCCAAA	uc003dfi.3	-	5	535_539	c.396_400delTTTGG	c.(394-402)CTTTTGGAAfs	p.L132fs	GLT8D1_uc003dfj.2_Frame_Shift_Del_p.L132fs|GLT8D1_uc003dfk.2_Frame_Shift_Del_p.L132fs|GLT8D1_uc003dfl.2_Frame_Shift_Del_p.L132fs|GLT8D1_uc003dfm.2_Frame_Shift_Del_p.L132fs|GLT8D1_uc003dfn.2_Frame_Shift_Del_p.L132fs|GLT8D1_uc003dfo.1_Frame_Shift_Del_p.L132fs	NM_152932	NP_690909	Q68CQ7	GL8D1_HUMAN	glycosyltransferase 8 domain containing 1	132_134	Lumenal (Potential).					integral to membrane|mitochondrion	transferase activity, transferring glycosyl groups				0				BRCA - Breast invasive adenocarcinoma(193;6.78e-05)|Kidney(197;0.000618)|KIRC - Kidney renal clear cell carcinoma(197;0.000779)|OV - Ovarian serous cystadenocarcinoma(275;0.0482)		ACTTTTCCTTCCAAAAGTTTAGGGT	0.39			NA											7	30	---	---	---	---	NA	NA	NA	NA	NA
WWC2	80014	broad.mit.edu	37	4	184182555	184182555	+	Frame_Shift_Del	DEL	T	T	-			TCGA-69-7761-01A-11D-2167-08	TCGA-69-7761-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3986bd8-e8b0-4bcf-b850-abcbac67485f	e5f8e6d1-e696-4867-9857-6ef6b9a05262	g.chr4:184182555delT	uc010irx.2	+	11	1961	c.1779delT	c.(1777-1779)CATfs	p.H593fs	WWC2_uc003ivk.3_Frame_Shift_Del_p.H388fs|WWC2_uc003ivl.3_RNA|WWC2_uc010iry.2_Frame_Shift_Del_p.H275fs|WWC2_uc003ivn.3_Intron	NM_024949	NP_079225	Q6AWC2	WWC2_HUMAN	WW and C2 domain containing 2	593										ovary(2)|lung(1)	3		all_lung(41;5.28e-14)|Lung NSC(41;1.35e-13)|Colorectal(36;0.00681)|Hepatocellular(41;0.00886)|Renal(120;0.00992)|Prostate(90;0.0237)|all_hematologic(60;0.0592)|Esophageal squamous(56;0.179)|all_neural(102;0.202)		all cancers(43;3.38e-24)|Epithelial(43;1.4e-20)|OV - Ovarian serous cystadenocarcinoma(60;1.09e-09)|GBM - Glioblastoma multiforme(59;3.33e-05)|Colorectal(24;3.58e-05)|STAD - Stomach adenocarcinoma(60;4.21e-05)|COAD - Colon adenocarcinoma(29;0.000171)|LUSC - Lung squamous cell carcinoma(40;0.0145)|READ - Rectum adenocarcinoma(43;0.242)		TGAGTAGCCATTTTGCAGATA	0.448			NA											2	4	---	---	---	---	NA	NA	NA	NA	NA
MTUS1	57509	broad.mit.edu	37	8	17611606	17611606	+	Frame_Shift_Del	DEL	T	T	-			TCGA-69-7761-01A-11D-2167-08	TCGA-69-7761-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3986bd8-e8b0-4bcf-b850-abcbac67485f	e5f8e6d1-e696-4867-9857-6ef6b9a05262	g.chr8:17611606delT	uc003wxv.2	-	2	2185	c.1711delA	c.(1711-1713)ATTfs	p.I571fs	MTUS1_uc010lsy.2_RNA|MTUS1_uc003wxw.2_Frame_Shift_Del_p.I571fs|MTUS1_uc010lsz.2_Frame_Shift_Del_p.I571fs	NM_001001924	NP_001001924	Q9ULD2	MTUS1_HUMAN	mitochondrial tumor suppressor 1 isoform 1	571						Golgi apparatus|microtubule|microtubule organizing center|mitochondrion|nucleus|plasma membrane|spindle				ovary(1)|skin(1)	2				Colorectal(111;0.0778)		GTCTTGTTAATTAGAATTTCT	0.398			NA											42	198	---	---	---	---	NA	NA	NA	NA	NA
ZNF367	195828	broad.mit.edu	37	9	99180258	99180259	+	In_Frame_Ins	INS	-	-	GGC			TCGA-69-7761-01A-11D-2167-08	TCGA-69-7761-10A-01D-2167-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b3986bd8-e8b0-4bcf-b850-abcbac67485f	e5f8e6d1-e696-4867-9857-6ef6b9a05262	g.chr9:99180258_99180259insGGC	uc004awf.2	-	1	411_412	c.56_57insGCC	c.(55-57)CCC>CCGCCC	p.19_19P>PP	ZNF367_uc004awg.2_In_Frame_Ins_p.19_19P>PP	NM_153695	NP_710162	Q7RTV3	ZN367_HUMAN	zinc finger protein 367	19	Pro-rich.				regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Acute lymphoblastic leukemia(62;0.0167)				AGAAGATGACGggcggcggcgg	0.653			NA											6	7	---	---	---	---	NA	NA	NA	NA	NA