Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	ACHILLES_Top_Genes	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
DLGAP3	58512	broad.mit.edu	37	1	35369906	35369906	+	Missense_Mutation	SNP	G	G	A			TCGA-67-3773-01A-01D-1040-01	TCGA-67-3773-10A-01D-1489-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	593cee5f-98b3-4f51-bd9f-3bf3dbb6d1d1	2e4532d8-cebf-4bdf-95d0-5c02f94d186e	g.chr1:35369906G>A	uc001byc.2	-	1	1079	c.1079C>T	c.(1078-1080)GCC>GTC	p.A360V		NM_001080418	NP_001073887	O95886	DLGP3_HUMAN	discs, large (Drosophila) homolog-associated	360					cell-cell signaling	cell junction|postsynaptic density|postsynaptic membrane				ovary(3)	3		Myeloproliferative disorder(586;0.0393)				CCTGGCTTTGGCCTTGGTCTC	0.592			NA											71	154					0	0	0.01441	0	0
C1orf173	127254	broad.mit.edu	37	1	75038095	75038095	+	Missense_Mutation	SNP	G	G	T			TCGA-67-3773-01A-01D-1040-01	TCGA-67-3773-10A-01D-1489-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	593cee5f-98b3-4f51-bd9f-3bf3dbb6d1d1	2e4532d8-cebf-4bdf-95d0-5c02f94d186e	g.chr1:75038095G>T	uc001dgg.2	-	14	3518	c.3299C>A	c.(3298-3300)GCG>GAG	p.A1100E		NM_001002912	NP_001002912	Q5RHP9	CA173_HUMAN	hypothetical protein LOC127254	1100	Glu-rich.									ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	5						CCCTTCTTCCGCTTTAAGTTT	0.443			NA											61	154					2.22609e-26	3.47269e-26	0.01441	1	0
LPPR4	9890	broad.mit.edu	37	1	99772407	99772407	+	Missense_Mutation	SNP	C	C	A			TCGA-67-3773-01A-01D-1040-01	TCGA-67-3773-10A-01D-1489-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	593cee5f-98b3-4f51-bd9f-3bf3dbb6d1d1	2e4532d8-cebf-4bdf-95d0-5c02f94d186e	g.chr1:99772407C>A	uc001dse.2	+	7	2239	c.2133C>A	c.(2131-2133)AGC>AGA	p.S711R	LPPR4_uc010oue.1_Missense_Mutation_p.S653R	NM_014839	NP_055654	Q7Z2D5	LPPR4_HUMAN	plasticity related gene 1	711							phosphatidate phosphatase activity			ovary(3)	3		all_epithelial(167;3.54e-06)|all_lung(203;0.00139)|Lung NSC(277;0.00202)		Epithelial(280;0.0736)|all cancers(265;0.0975)|COAD - Colon adenocarcinoma(174;0.142)|Lung(183;0.201)|Colorectal(170;0.22)		TAGAGGGCAGCGAAATTGGCT	0.522			NA											16	38					6.72482e-11	8.96643e-11	0.003163	1	0
MOV10	4343	broad.mit.edu	37	1	113217566	113217566	+	Missense_Mutation	SNP	G	G	T			TCGA-67-3773-01A-01D-1040-01	TCGA-67-3773-10A-01D-1489-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	593cee5f-98b3-4f51-bd9f-3bf3dbb6d1d1	2e4532d8-cebf-4bdf-95d0-5c02f94d186e	g.chr1:113217566G>T	uc001eck.2	+	2	302	c.32G>T	c.(31-33)CGG>CTG	p.R11L	MOV10_uc001ecl.2_Missense_Mutation_p.R11L|MOV10_uc001ecn.2_Missense_Mutation_p.R11L|MOV10_uc001ecm.2_5'UTR|MOV10_uc009wgj.1_5'UTR	NM_001130079	NP_001123551	Q9HCE1	MOV10_HUMAN	Mov10, Moloney leukemia virus 10, homolog	11					mRNA cleavage involved in gene silencing by miRNA|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body	ATP binding|helicase activity|protein binding|RNA binding			ovary(4)|skin(1)	5	Lung SC(450;0.246)	all_cancers(81;3.31e-11)|all_epithelial(167;5.69e-10)|all_lung(203;3.73e-05)|Breast(1374;0.000525)|Lung NSC(69;0.000954)|Ovarian(761;0.0367)|Lung SC(238;0.114)		OV - Ovarian serous cystadenocarcinoma(397;3.99e-67)|all cancers(265;1e-62)|Epithelial(280;4.78e-61)|Lung(183;0.0234)|Colorectal(144;0.0686)|READ - Rectum adenocarcinoma(129;0.0929)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)|BRCA - Breast invasive adenocarcinoma(282;0.24)		CGGCAGCTCCGGGAGGCGGGC	0.632			NA											39	75					6.4685e-43	1.04029e-42	0.01441	1	0
SPAG17	200162	broad.mit.edu	37	1	118554977	118554977	+	Missense_Mutation	SNP	C	C	A			TCGA-67-3773-01A-01D-1040-01	TCGA-67-3773-10A-01D-1489-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	593cee5f-98b3-4f51-bd9f-3bf3dbb6d1d1	2e4532d8-cebf-4bdf-95d0-5c02f94d186e	g.chr1:118554977C>A	uc001ehk.2	-	30	4374	c.4306G>T	c.(4306-4308)GAC>TAC	p.D1436Y		NM_206996	NP_996879	Q6Q759	SPG17_HUMAN	sperm associated antigen 17	1436						cilium|flagellar axoneme|microtubule				upper_aerodigestive_tract(2)|ovary(2)|large_intestine(1)|skin(1)	6	Esophageal squamous(2;0.0106)	all_cancers(81;0.0204)|all_lung(203;9.46e-05)|Lung NSC(69;0.000675)|all_epithelial(167;0.01)		Lung(183;0.0858)		ACAACTTTGTCTTCTCGAGTT	0.378			NA											23	57					6.44725e-10	8.38143e-10	0.014323	1	0
RPTN	126638	broad.mit.edu	37	1	152128367	152128367	+	Missense_Mutation	SNP	T	T	A			TCGA-67-3773-01A-01D-1040-01	TCGA-67-3773-10A-01D-1489-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	593cee5f-98b3-4f51-bd9f-3bf3dbb6d1d1	2e4532d8-cebf-4bdf-95d0-5c02f94d186e	g.chr1:152128367T>A	uc001ezs.1	-	3	1273	c.1208A>T	c.(1207-1209)TAT>TTT	p.Y403F		NM_001122965	NP_001116437	Q6XPR3	RPTN_HUMAN	repetin	403	Gln-rich.					proteinaceous extracellular matrix	calcium ion binding				0						TGTCTGACCATAGTGAGAACT	0.507			NA											315	631					0	0	0.01441	0	0
SPTA1	6708	broad.mit.edu	37	1	158627290	158627290	+	Missense_Mutation	SNP	C	C	T			TCGA-67-3773-01A-01D-1040-01	TCGA-67-3773-10A-01D-1489-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	593cee5f-98b3-4f51-bd9f-3bf3dbb6d1d1	2e4532d8-cebf-4bdf-95d0-5c02f94d186e	g.chr1:158627290C>T	uc001fst.1	-	19	2981	c.2782G>A	c.(2782-2784)GGT>AGT	p.G928S		NM_003126	NP_003117	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1	928	Spectrin 10.				actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|breast(1)	8	all_hematologic(112;0.0378)					TCATCAGCACCATAGTTAGTA	0.438			NA											28	53					0	0	0.005443	0	0
IGSF8	93185	broad.mit.edu	37	1	160061677	160061677	+	Missense_Mutation	SNP	A	A	T			TCGA-67-3773-01A-01D-1040-01	TCGA-67-3773-10A-01D-1489-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	593cee5f-98b3-4f51-bd9f-3bf3dbb6d1d1	2e4532d8-cebf-4bdf-95d0-5c02f94d186e	g.chr1:160061677A>T	uc001fva.2	-	6	1823	c.1778T>A	c.(1777-1779)GTC>GAC	p.V593D	IGSF8_uc001fuz.2_Missense_Mutation_p.V593D|IGSF8_uc009wtf.2_Missense_Mutation_p.V593D	NM_052868	NP_443100	Q969P0	IGSF8_HUMAN	immunoglobulin superfamily, member 8	593	Helical; (Potential).				cell proliferation|cellular component movement|nervous system development|single fertilization|skeletal muscle tissue development	integral to membrane	protein binding				0	all_cancers(52;1.11e-16)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)|LUSC - Lung squamous cell carcinoma(543;0.246)			GGCACCAGTGACTAGGGCCAC	0.567			NA											59	135					0	0	0.01441	0	0
ASTN1	460	broad.mit.edu	37	1	176857323	176857323	+	Silent	SNP	G	G	T			TCGA-67-3773-01A-01D-1040-01	TCGA-67-3773-10A-01D-1489-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	593cee5f-98b3-4f51-bd9f-3bf3dbb6d1d1	2e4532d8-cebf-4bdf-95d0-5c02f94d186e	g.chr1:176857323G>T	uc001glc.2	-	18	3170	c.2958C>A	c.(2956-2958)ACC>ACA	p.T986T	ASTN1_uc001glb.1_Silent_p.T986T|ASTN1_uc001gld.1_Silent_p.T986T	NM_004319	NP_004310	O14525	ASTN1_HUMAN	astrotactin isoform 1	994					cell migration|neuron cell-cell adhesion	integral to membrane				ovary(6)|skin(5)|central_nervous_system(2)|large_intestine(1)|lung(1)	15						GAGAGCTCATGGTAGCCTCCT	0.537			NA											27	69					2.49675e-24	3.85636e-24	0.007291	1	0
HSD11B1	3290	broad.mit.edu	37	1	209878375	209878376	+	Splice_Site	DNP	GG	GG	TT			TCGA-67-3773-01A-01D-1040-01	TCGA-67-3773-10A-01D-1489-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	593cee5f-98b3-4f51-bd9f-3bf3dbb6d1d1	2e4532d8-cebf-4bdf-95d0-5c02f94d186e	g.chr1:209878375_209878376GG>TT	uc001hhj.2	+	2	195	c.88_splice	c.e2+1	p.E30_splice	HSD11B1_uc001hhk.2_Splice_Site_p.E30_splice	NM_181755	NP_861420	P28845	DHI1_HUMAN	11-beta-hydroxysteroid dehydrogenase 1						glucocorticoid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	11-beta-hydroxysteroid dehydrogenase (NADP+) activity|11-beta-hydroxysteroid dehydrogenase|binding			breast(1)	1				OV - Ovarian serous cystadenocarcinoma(81;1.04e-55)|Epithelial(68;1.57e-52)|all cancers(67;1.83e-46)|Colorectal(1306;0.115)	NADH(DB00157)	ATTCAGACCAGGTAAGTACCCA	0.45			NA											28	79					0	0	0.004672	0	0
USH2A	7399	broad.mit.edu	37	1	216074227	216074227	+	Missense_Mutation	SNP	G	G	A			TCGA-67-3773-01A-01D-1040-01	TCGA-67-3773-10A-01D-1489-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	593cee5f-98b3-4f51-bd9f-3bf3dbb6d1d1	2e4532d8-cebf-4bdf-95d0-5c02f94d186e	g.chr1:216074227G>A	uc001hku.1	-	39	7708	c.7321C>T	c.(7321-7323)CCC>TCC	p.P2441S		NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	2441	Extracellular (Potential).|Fibronectin type-III 11.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		GAAAGCCTGGGAGGCAGCACG	0.493			NA								HNSCC(13;0.011)			19	38					0	0	0.006122	0	0
FMN2	56776	broad.mit.edu	37	1	240371207	240371207	+	Missense_Mutation	SNP	C	C	T			TCGA-67-3773-01A-01D-1040-01	TCGA-67-3773-10A-01D-1489-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	593cee5f-98b3-4f51-bd9f-3bf3dbb6d1d1	2e4532d8-cebf-4bdf-95d0-5c02f94d186e	g.chr1:240371207C>T	uc010pyd.1	+	5	3320	c.3095C>T	c.(3094-3096)CCT>CTT	p.P1032L	FMN2_uc010pye.1_Missense_Mutation_p.P1036L	NM_020066	NP_064450	Q9NZ56	FMN2_HUMAN	formin 2	1032	Pro-rich.|FH1.				actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			ovary(4)|pancreas(3)|skin(3)|large_intestine(1)|central_nervous_system(1)	12	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			GGCATACCCCCTCCGCCCCCA	0.731			NA											3	20					0	0	0.009096	0	0
CDK1	983	broad.mit.edu	37	10	62544479	62544479	+	Silent	SNP	G	G	C			TCGA-67-3773-01A-01D-1040-01	TCGA-67-3773-10A-01D-1489-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	593cee5f-98b3-4f51-bd9f-3bf3dbb6d1d1	2e4532d8-cebf-4bdf-95d0-5c02f94d186e	g.chr10:62544479G>C	uc001jld.2	+	3	188	c.54G>C	c.(52-54)GTG>GTC	p.V18V	CDK1_uc010qii.1_Silent_p.V18V|CDK1_uc001jle.2_RNA|CDK1_uc001jlf.2_Silent_p.V18V|CDK1_uc001jlg.2_Silent_p.V18V	NM_001786	NP_001777	P06493	CDK1_HUMAN	cell division cycle 2 isoform 1	18	ATP (By similarity).|Protein kinase.				activation of MAPK activity|activation of MAPKK activity|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|anti-apoptosis|axon guidance|cell division|epidermal growth factor receptor signaling pathway|innate immune response|insulin receptor signaling pathway|mitosis|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein localization to kinetochore|Ras protein signal transduction|regulation of transcription involved in G1/S phase of mitotic cell cycle|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|midbody|nucleoplasm|spindle microtubule	ATP binding|cyclin-dependent protein kinase activity|RNA polymerase II carboxy-terminal domain kinase activity			ovary(1)	1						ATGGAGTTGTGTATAAGGGTA	0.338			NA											37	68					0	0	0.015359	0	0
OR51A4	401666	broad.mit.edu	37	11	4967760	4967760	+	Missense_Mutation	SNP	A	A	T			TCGA-67-3773-01A-01D-1040-01	TCGA-67-3773-10A-01D-1489-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	593cee5f-98b3-4f51-bd9f-3bf3dbb6d1d1	2e4532d8-cebf-4bdf-95d0-5c02f94d186e	g.chr11:4967760A>T	uc010qys.1	-	1	571	c.571T>A	c.(571-573)TGT>AGT	p.C191S		NM_001005329	NP_001005329	Q8NGJ6	O51A4_HUMAN	olfactory receptor, family 51, subfamily A,	191	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;3.22e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0284)|LUSC - Lung squamous cell carcinoma(625;0.19)		TTGTCAGAACAGGCCAACTTC	0.408			NA											14	51					0	0	0.008871	0	0
OR52J3	119679	broad.mit.edu	37	11	5068314	5068314	+	Missense_Mutation	SNP	G	G	A			TCGA-67-3773-01A-01D-1040-01	TCGA-67-3773-10A-01D-1489-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	593cee5f-98b3-4f51-bd9f-3bf3dbb6d1d1	2e4532d8-cebf-4bdf-95d0-5c02f94d186e	g.chr11:5068314G>A	uc010qyv.1	+	1	559	c.559G>A	c.(559-561)GCA>ACA	p.A187T		NM_001001916	NP_001001916	Q8NH60	O52J3_HUMAN	olfactory receptor, family 52, subfamily J,	187	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|lung(1)|skin(1)	3		Medulloblastoma(188;0.00131)|all_neural(188;0.0189)|Breast(177;0.0204)		Epithelial(150;9.29e-10)|BRCA - Breast invasive adenocarcinoma(625;0.135)|LUSC - Lung squamous cell carcinoma(625;0.19)		CATGGGCATTGCAAAATTGTC	0.428			NA											17	56					0	0	0.004007	0	0
TRIM22	10346	broad.mit.edu	37	11	5730700	5730700	+	Missense_Mutation	SNP	C	C	T			TCGA-67-3773-01A-01D-1040-01	TCGA-67-3773-10A-01D-1489-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	593cee5f-98b3-4f51-bd9f-3bf3dbb6d1d1	2e4532d8-cebf-4bdf-95d0-5c02f94d186e	g.chr11:5730700C>T	uc001mbr.2	+	8	1596	c.1319C>T	c.(1318-1320)CCC>CTC	p.P440L	TRIM5_uc001mbq.1_Intron|TRIM22_uc009yet.1_Intron|TRIM22_uc009yes.2_Missense_Mutation_p.P436L|TRIM22_uc010qzm.1_Missense_Mutation_p.P268L|TRIM22_uc009yeu.2_Missense_Mutation_p.P251L|OR56B1_uc001mbs.1_Intron|OR56B1_uc009yev.1_Intron	NM_006074	NP_006065	Q8IYM9	TRI22_HUMAN	tripartite motif-containing 22	440	B30.2/SPRY.				immune response|interspecies interaction between organisms|protein trimerization|response to virus	Cajal body|Golgi apparatus|nuclear speck	ligase activity|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding				0		Medulloblastoma(188;0.00225)|Breast(177;0.0204)|all_neural(188;0.0212)		Epithelial(150;7.54e-09)|BRCA - Breast invasive adenocarcinoma(625;0.14)		GCTGTGCCTCCCTGTCGTATT	0.438	GBM(104;491 2336 5222)		NA											68	136					0	0	0.01441	0	0
DNHD1	144132	broad.mit.edu	37	11	6588836	6588836	+	Missense_Mutation	SNP	G	G	A			TCGA-67-3773-01A-01D-1040-01	TCGA-67-3773-10A-01D-1489-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	593cee5f-98b3-4f51-bd9f-3bf3dbb6d1d1	2e4532d8-cebf-4bdf-95d0-5c02f94d186e	g.chr11:6588836G>A	uc001mdw.3	+	36	12661	c.12097G>A	c.(12097-12099)GAG>AAG	p.E4033K	DNHD1_uc001mea.3_Missense_Mutation_p.E302K|DNHD1_uc001meb.2_Missense_Mutation_p.E301K|DNHD1_uc001mec.2_Missense_Mutation_p.E301K|DNHD1_uc010rao.1_Missense_Mutation_p.E291K|DNHD1_uc009yfg.2_5'Flank	NM_144666	NP_653267	Q96M86	DNHD1_HUMAN	dynein heavy chain domain 1 isoform 1	4033					microtubule-based movement	dynein complex	microtubule motor activity			ovary(2)	2		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.171)		Epithelial(150;3.93e-08)|BRCA - Breast invasive adenocarcinoma(625;0.13)		GCCAGGGCCTGAGCCACTCAG	0.642			NA											19	34					0	0	0.008871	0	0
CTNND1	1500	broad.mit.edu	37	11	57569381	57569381	+	Missense_Mutation	SNP	G	G	T			TCGA-67-3773-01A-01D-1040-01	TCGA-67-3773-10A-01D-1489-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	593cee5f-98b3-4f51-bd9f-3bf3dbb6d1d1	2e4532d8-cebf-4bdf-95d0-5c02f94d186e	g.chr11:57569381G>T	uc001nmc.3	+	7	1704	c.1133G>T	c.(1132-1134)CGC>CTC	p.R378L	CTNND1_uc001nlh.1_Missense_Mutation_p.R378L|CTNND1_uc001nlu.3_Missense_Mutation_p.R277L|CTNND1_uc001nlt.3_Missense_Mutation_p.R277L|CTNND1_uc001nls.3_Missense_Mutation_p.R277L|CTNND1_uc001nlw.3_Missense_Mutation_p.R277L|CTNND1_uc001nmf.3_Missense_Mutation_p.R378L|CTNND1_uc001nmd.3_Missense_Mutation_p.R324L|CTNND1_uc001nlk.3_Missense_Mutation_p.R324L|CTNND1_uc001nme.3_Missense_Mutation_p.R378L|CTNND1_uc001nll.3_Missense_Mutation_p.R324L|CTNND1_uc001nmg.3_Missense_Mutation_p.R324L|CTNND1_uc001nlj.3_Missense_Mutation_p.R324L|CTNND1_uc001nlr.3_Missense_Mutation_p.R324L|CTNND1_uc001nlp.3_Missense_Mutation_p.R324L|CTNND1_uc001nlx.3_Missense_Mutation_p.R55L|CTNND1_uc001nlz.3_Missense_Mutation_p.R55L|CTNND1_uc009ymn.2_Missense_Mutation_p.R55L|CTNND1_uc001nlm.3_Missense_Mutation_p.R378L|CTNND1_uc001nly.3_Missense_Mutation_p.R55L|CTNND1_uc001nmb.3_Missense_Mutation_p.R55L|CTNND1_uc001nma.3_Missense_Mutation_p.R55L|CTNND1_uc001nmi.3_Missense_Mutation_p.R277L|CTNND1_uc001nmh.3_Missense_Mutation_p.R378L|CTNND1_uc001nlq.3_Missense_Mutation_p.R277L|CTNND1_uc001nln.3_Missense_Mutation_p.R378L|CTNND1_uc001nli.3_Missense_Mutation_p.R378L|CTNND1_uc001nlo.3_Missense_Mutation_p.R277L|CTNND1_uc001nlv.3_Missense_Mutation_p.R277L	NM_001085458	NP_001078927	O60716	CTND1_HUMAN	catenin, delta 1 isoform 1ABC	378	ARM 1.				adherens junction organization|cell junction assembly|negative regulation of canonical Wnt receptor signaling pathway|regulation of transcription, DNA-dependent|transcription, DNA-dependent|Wnt receptor signaling pathway	cytosol|midbody|nucleus	cadherin binding|protein binding|receptor binding			breast(4)|ovary(1)|kidney(1)	6		all_epithelial(135;0.155)				CTTGGATTCCGCTTGGATGCT	0.542			NA											41	121					2.35958e-20	3.4726e-20	0.009718	1	0
OR9Q2	219957	broad.mit.edu	37	11	57958720	57958720	+	Missense_Mutation	SNP	G	G	A			TCGA-67-3773-01A-01D-1040-01	TCGA-67-3773-10A-01D-1489-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	593cee5f-98b3-4f51-bd9f-3bf3dbb6d1d1	2e4532d8-cebf-4bdf-95d0-5c02f94d186e	g.chr11:57958720G>A	uc010rka.1	+	1	758	c.758G>A	c.(757-759)GGC>GAC	p.G253D		NM_001005283	NP_001005283	Q8NGE9	OR9Q2_HUMAN	olfactory receptor, family 9, subfamily Q,	253	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|breast(1)|central_nervous_system(1)	4		Breast(21;0.0589)				CTTTTCTTTGGCACCCTCATC	0.577			NA											59	102					0	0	0.01441	0	0
GLYATL1	92292	broad.mit.edu	37	11	58711127	58711127	+	Translation_Start_Site	SNP	C	C	A			TCGA-67-3773-01A-01D-1040-01	TCGA-67-3773-10A-01D-1489-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	593cee5f-98b3-4f51-bd9f-3bf3dbb6d1d1	2e4532d8-cebf-4bdf-95d0-5c02f94d186e	g.chr11:58711127C>A	uc001nnf.2	+	3	322	c.-54C>A	c.(-56--52)GGCTG>GGATG		uc001nng.1_Intron|GLYATL1_uc001nnh.1_Missense_Mutation_p.L46M|GLYATL1_uc001nni.1_Translation_Start_Site|GLYATL1_uc001nnj.1_Translation_Start_Site			Q969I3	GLYL1_HUMAN	SubName: Full=Glycine acyltransferase family-C; SubName: Full=Glycine-N-acyltransferase-like 1, isoform CRA_a;							mitochondrion	glycine N-acyltransferase activity			ovary(1)	1					Glycine(DB00145)	ctcagagtggctgaggataat	0			NA											18	28					2.4624e-09	3.09785e-09	0.008871	1	0
INPPL1	3636	broad.mit.edu	37	11	71946219	71946219	+	Silent	SNP	C	C	T			TCGA-67-3773-01A-01D-1040-01	TCGA-67-3773-10A-01D-1489-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	593cee5f-98b3-4f51-bd9f-3bf3dbb6d1d1	2e4532d8-cebf-4bdf-95d0-5c02f94d186e	g.chr11:71946219C>T	uc001osf.2	+	22	2622	c.2475C>T	c.(2473-2475)GTC>GTT	p.V825V	INPPL1_uc001osg.2_Silent_p.V583V	NM_001567	NP_001558	O15357	SHIP2_HUMAN	inositol polyphosphate phosphatase-like 1	825					actin filament organization|cell adhesion|endocytosis	actin cortical patch|cytosol	actin binding|SH2 domain binding|SH3 domain binding			skin(2)|ovary(1)|breast(1)	4						TGCTCACAGTCAAGTCCATGG	0.557			NA											56	97					0	0	0.01441	0	0
ANKRD42	338699	broad.mit.edu	37	11	82917155	82917155	+	Missense_Mutation	SNP	G	G	T			TCGA-67-3773-01A-01D-1040-01	TCGA-67-3773-10A-01D-1489-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	593cee5f-98b3-4f51-bd9f-3bf3dbb6d1d1	2e4532d8-cebf-4bdf-95d0-5c02f94d186e	g.chr11:82917155G>T	uc001ozz.1	+	3	616	c.194G>T	c.(193-195)GGT>GTT	p.G65V	ANKRD42_uc009yvi.1_Missense_Mutation_p.G93V|ANKRD42_uc010rsv.1_Missense_Mutation_p.G93V|ANKRD42_uc001paa.2_Missense_Mutation_p.G93V|ANKRD42_uc001pab.1_Missense_Mutation_p.G93V	NM_182603	NP_872409	Q8N9B4	ANR42_HUMAN	ankyrin repeat domain 42	65	ANK 2.									skin(1)	1						ACAACGAGAGGTTGGACAGCA	0.378			NA											22	53					2.98393e-07	3.60848e-07	0.016522	1	0
MMP1	4312	broad.mit.edu	37	11	102667829	102667829	+	Missense_Mutation	SNP	G	G	T			TCGA-67-3773-01A-01D-1040-01	TCGA-67-3773-10A-01D-1489-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	593cee5f-98b3-4f51-bd9f-3bf3dbb6d1d1	2e4532d8-cebf-4bdf-95d0-5c02f94d186e	g.chr11:102667829G>T	uc001phi.2	-	3	558	c.415C>A	c.(415-417)CAA>AAA	p.Q139K	uc001phh.1_Intron|MMP1_uc010ruv.1_Missense_Mutation_p.Q73K	NM_002421	NP_002412	P03956	MMP1_HUMAN	matrix metalloproteinase 1 isoform 1	139	Metalloprotease.				blood coagulation|collagen catabolic process|interspecies interaction between organisms|leukocyte migration|proteolysis	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			skin(2)|ovary(1)|lung(1)	4	all_epithelial(12;0.0127)	all_neural(303;0.000318)|all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)	Epithelial(9;0.072)|Lung(13;0.0828)|LUSC - Lung squamous cell carcinoma(19;0.151)|all cancers(10;0.233)	OV - Ovarian serous cystadenocarcinoma(223;1.82e-07)|Epithelial(105;1.51e-06)|BRCA - Breast invasive adenocarcinoma(274;0.014)		CTCCAGAGTTGGAAGGCTTTC	0.423			NA											50	80					1.08114e-33	1.721e-33	0.01441	1	0
ZBTB16	7704	broad.mit.edu	37	11	114113048	114113048	+	Missense_Mutation	SNP	G	G	T			TCGA-67-3773-01A-01D-1040-01	TCGA-67-3773-10A-01D-1489-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	593cee5f-98b3-4f51-bd9f-3bf3dbb6d1d1	2e4532d8-cebf-4bdf-95d0-5c02f94d186e	g.chr11:114113048G>T	uc001pop.2	+	5	1877	c.1613G>T	c.(1612-1614)CGC>CTC	p.R538L	ZBTB16_uc001poq.2_Missense_Mutation_p.R538L	NM_006006	NP_005997	Q05516	ZBT16_HUMAN	promyelocytic leukemia zinc finger protein	538	C2H2-type 5.				apoptosis|central nervous system development|mesonephros development|myeloid cell differentiation|negative regulation of myeloid cell differentiation|negative regulation of transcription, DNA-dependent	nuclear speck|PML body|transcriptional repressor complex	protein homodimerization activity|zinc ion binding			central_nervous_system(1)|skin(1)	2		all_cancers(61;3.79e-18)|all_epithelial(67;2.32e-10)|all_hematologic(158;2.96e-05)|Melanoma(852;0.000362)|Acute lymphoblastic leukemia(157;0.00108)|Breast(348;0.0104)|all_neural(223;0.0294)|Prostate(24;0.0318)|Medulloblastoma(222;0.0438)		BRCA - Breast invasive adenocarcinoma(274;6.75e-06)|Epithelial(105;0.000181)|all cancers(92;0.0018)		CGCCACCTGCGCTCACATACA	0.602			NA											15	53					1.9806e-07	2.41385e-07	0.014323	1	0
MFRP	83552	broad.mit.edu	37	11	119217000	119217000	+	Missense_Mutation	SNP	C	C	T	rs143802236	byFrequency	TCGA-67-3773-01A-01D-1040-01	TCGA-67-3773-10A-01D-1489-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	593cee5f-98b3-4f51-bd9f-3bf3dbb6d1d1	2e4532d8-cebf-4bdf-95d0-5c02f94d186e	g.chr11:119217000C>T	uc001pwj.2	-	2	299	c.139G>A	c.(139-141)GTC>ATC	p.V47I	MFRP_uc010rzf.1_RNA|MFRP_uc010rzg.1_Missense_Mutation_p.V47I	NM_031433	NP_113621	Q9BXJ0	C1QT5_HUMAN	membrane frizzled-related protein	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment						collagen					0		Medulloblastoma(222;0.0523)|Breast(348;0.174)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;3.84e-05)		GGAGCTGGGACGCTGTAGCTG	0.617			NA											12	34					0	0	0.013537	0	0
TECTA	7007	broad.mit.edu	37	11	120989078	120989078	+	Missense_Mutation	SNP	G	G	T			TCGA-67-3773-01A-01D-1040-01	TCGA-67-3773-10A-01D-1489-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	593cee5f-98b3-4f51-bd9f-3bf3dbb6d1d1	2e4532d8-cebf-4bdf-95d0-5c02f94d186e	g.chr11:120989078G>T	uc010rzo.1	+	6	854	c.854G>T	c.(853-855)TGT>TTT	p.C285F		NM_005422	NP_005413	O75443	TECTA_HUMAN	tectorin alpha precursor	285	VWFC.				cell-matrix adhesion|sensory perception of sound	anchored to membrane|plasma membrane|proteinaceous extracellular matrix				breast(6)|ovary(2)|skin(2)	10	all_hematologic(175;0.208)	Breast(109;0.000766)|Medulloblastoma(222;0.0427)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;8.04e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.166)		AAGTGCCGCTGTCTGGATTTC	0.473			NA											54	78					3.21867e-24	4.92268e-24	0.01441	1	0
GRAMD1B	57476	broad.mit.edu	37	11	123489404	123489404	+	Silent	SNP	G	G	T			TCGA-67-3773-01A-01D-1040-01	TCGA-67-3773-10A-01D-1489-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	593cee5f-98b3-4f51-bd9f-3bf3dbb6d1d1	2e4532d8-cebf-4bdf-95d0-5c02f94d186e	g.chr11:123489404G>T	uc001pyx.2	+	18	2234	c.1905G>T	c.(1903-1905)CTG>CTT	p.L635L	GRAMD1B_uc001pyw.2_Silent_p.L642L|GRAMD1B_uc010rzw.1_Silent_p.L591L|GRAMD1B_uc010rzx.1_Silent_p.L595L|GRAMD1B_uc001pyy.2_Silent_p.L322L	NM_020716	NP_065767	Q3KR37	GRM1B_HUMAN	GRAM domain containing 1B	635	Helical; (Potential).					integral to membrane				ovary(1)	1		Breast(109;0.00204)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.32e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0394)		TTCCTAGTCTGGTGCTGCTGG	0.547			NA											3	1					0.004672	0.00495804	0.004672	1	0
CACNA1C	775	broad.mit.edu	37	12	2797654	2797654	+	Missense_Mutation	SNP	C	C	A			TCGA-67-3773-01A-01D-1040-01	TCGA-67-3773-10A-01D-1489-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	593cee5f-98b3-4f51-bd9f-3bf3dbb6d1d1	2e4532d8-cebf-4bdf-95d0-5c02f94d186e	g.chr12:2797654C>A	uc009zdu.1	+	49	6388	c.6075C>A	c.(6073-6075)AGC>AGA	p.S2025R	CACNA1C_uc009zdv.1_Missense_Mutation_p.S1939R|CACNA1C_uc001qkb.2_Missense_Mutation_p.S1942R|CACNA1C_uc001qkc.2_Missense_Mutation_p.S1961R|CACNA1C_uc001qke.2_Missense_Mutation_p.S1931R|CACNA1C_uc001qkf.2_Missense_Mutation_p.S1950R|CACNA1C_uc001qjz.2_Missense_Mutation_p.S1942R|CACNA1C_uc001qkd.2_Missense_Mutation_p.S1961R|CACNA1C_uc001qkg.2_Missense_Mutation_p.S1948R|CACNA1C_uc009zdw.1_Missense_Mutation_p.S1983R|CACNA1C_uc001qkh.2_Missense_Mutation_p.S1950R|CACNA1C_uc001qkl.2_Missense_Mutation_p.S1990R|CACNA1C_uc001qkn.2_Missense_Mutation_p.S1942R|CACNA1C_uc001qko.2_Missense_Mutation_p.S1962R|CACNA1C_uc001qkp.2_Missense_Mutation_p.S1942R|CACNA1C_uc001qkr.2_Missense_Mutation_p.S1959R|CACNA1C_uc001qku.2_Missense_Mutation_p.S1977R|CACNA1C_uc001qkq.2_Missense_Mutation_p.S1970R|CACNA1C_uc001qks.2_Missense_Mutation_p.S1942R|CACNA1C_uc001qkt.2_Missense_Mutation_p.S1961R|CACNA1C_uc001qki.1_Missense_Mutation_p.S1749R|CACNA1C_uc001qkj.1_Missense_Mutation_p.S1713R|CACNA1C_uc001qkk.1_Missense_Mutation_p.S1678R|CACNA1C_uc001qkm.1_Missense_Mutation_p.S1738R|CACNA1C_uc010sea.1_Missense_Mutation_p.S633R|uc001qkx.1_Intron|CACNA1C_uc001qky.1_Missense_Mutation_p.S260R	NM_199460	NP_955630	Q13936	CAC1C_HUMAN	calcium channel, voltage-dependent, L type,	2025	Cytoplasmic (Potential).				axon guidance|calcium ion transport into cytosol|energy reserve metabolic process|regulation of insulin secretion	cytoplasm|postsynaptic density|voltage-gated calcium channel complex	calmodulin binding|voltage-gated calcium channel activity			ovary(10)|central_nervous_system(1)	11			OV - Ovarian serous cystadenocarcinoma(31;0.00256)	LUAD - Lung adenocarcinoma(1;0.134)	Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Nicardipine(DB00622)|Verapamil(DB00661)	TCCAGAGAAGCCATTCCCCTG	0.652			NA											41	85					1.49673e-21	2.2669e-21	0.00623	1	0
KLRC2	3822	broad.mit.edu	37	12	10584778	10584778	+	Missense_Mutation	SNP	A	A	G			TCGA-67-3773-01A-01D-1040-01	TCGA-67-3773-10A-01D-1489-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	593cee5f-98b3-4f51-bd9f-3bf3dbb6d1d1	2e4532d8-cebf-4bdf-95d0-5c02f94d186e	g.chr12:10584778A>G	uc001qyk.2	-	5	518	c.511T>C	c.(511-513)TCA>CCA	p.S171P	KLRC3_uc001qyh.2_Intron|KLRC2_uc010she.1_Missense_Mutation_p.S171P	NM_002260	NP_002251	P26717	NKG2C_HUMAN	killer cell lectin-like receptor subfamily C,	171	Extracellular (Potential).|C-type lectin.				cellular defense response	integral to plasma membrane	sugar binding|transmembrane receptor activity				0						CCAATCCATGAGGAAGGTAAA	0.299			NA											12	26					0	0	0.016723	0	0
KIAA1467	57613	broad.mit.edu	37	12	13229033	13229033	+	Missense_Mutation	SNP	T	T	A			TCGA-67-3773-01A-01D-1040-01	TCGA-67-3773-10A-01D-1489-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	593cee5f-98b3-4f51-bd9f-3bf3dbb6d1d1	2e4532d8-cebf-4bdf-95d0-5c02f94d186e	g.chr12:13229033T>A	uc001rbi.2	+	11	1621	c.1598T>A	c.(1597-1599)CTT>CAT	p.L533H	KIAA1467_uc009zhx.1_RNA	NM_020853	NP_065904	A2RU67	K1467_HUMAN	hypothetical protein LOC57613	533						integral to membrane				central_nervous_system(2)|skin(1)	3		Prostate(47;0.184)		BRCA - Breast invasive adenocarcinoma(232;0.157)		CCCTCCATCCTTCTGGATCTG	0.552			NA											58	96					0	0	0.01441	0	0
KRAS	3845	broad.mit.edu	37	12	25398284	25398284	+	Missense_Mutation	SNP	C	C	A	rs121913529		TCGA-67-3773-01A-01D-1040-01	TCGA-67-3773-10A-01D-1489-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	593cee5f-98b3-4f51-bd9f-3bf3dbb6d1d1	2e4532d8-cebf-4bdf-95d0-5c02f94d186e	g.chr12:25398284C>A	uc001rgp.1	-	2	216	c.35G>T	c.(34-36)GGT>GTT	p.G12V	KRAS_uc001rgq.1_Missense_Mutation_p.G12V|KRAS_uc001rgr.2_RNA	NM_033360	NP_203524	P01116	RASK_HUMAN	c-K-ras2 protein isoform a precursor	12	GTP.		G -> D (in pancreatic carcinoma, GASC and lung carcinoma; somatic mutation).|G -> R (in lung cancer and bladder cancer; somatic mutation).|G -> S (in lung carcinoma and GASC; somatic mutation).|G -> A (in a colorectal cancer sample; somatic mutation).|G -> C (in lung carcinoma; somatic mutation).|G -> V (in lung carcinoma, pancreatic carcinoma, colon cancer and GASC; somatic mutation).		activation of MAPKK activity|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	plasma membrane	GTP binding|GTPase activity|protein binding	p.G12D(7175)|p.G12V(4780)|p.G12C(2482)|p.G12A(1180)|p.G12S(1119)|p.G12R(691)|p.G12?(50)|p.G12F(34)|p.G12N(6)|p.G12G(6)|p.G12L(5)|p.G12I(4)|p.G12_G13insG(4)|p.G12E(3)|p.G12W(3)|p.A11_G12insGA(2)|p.G12Y(2)|p.G12fs*3(1)		large_intestine(12391)|pancreas(3285)|lung(2847)|biliary_tract(521)|ovary(443)|endometrium(339)|haematopoietic_and_lymphoid_tissue(318)|stomach(203)|thyroid(149)|prostate(85)|soft_tissue(77)|small_intestine(62)|upper_aerodigestive_tract(59)|cervix(49)|urinary_tract(48)|skin(38)|liver(31)|breast(28)|testis(17)|oesophagus(15)|central_nervous_system(9)|peritoneum(6)|salivary_gland(6)|kidney(5)|gastrointestinal_tract_(site_indeterminate)(5)|thymus(5)|eye(4)|autonomic_ganglia(2)|bone(2)|genital_tract(1)|penis(1)|adrenal_gland(1)	21052	all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)		OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)			GCCTACGCCACCAGCTCCAAC	0.348	Pancreas(8;6 143 191 305 2070 2426 4376 10944 11745 26467 38091 50869)	G12D(HPAC_PANCREAS)|G12V(SW403_LARGE_INTESTINE)|G12D(HPAFII_PANCREAS)|G12D(PANC0403_PANCREAS)|G12D(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(KMS28BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12V(NCIH441_LUNG)|G12D(SU8686_PANCREAS)|G12D(SUIT2_PANCREAS)|G12D(PK1_PANCREAS)|G12V(KP3_PANCREAS)|G12D(PANC0813_PANCREAS)|G12A(SW1116_LARGE_INTESTINE)|G12D(LS180_LARGE_INTESTINE)|G12V(NCIH727_LUNG)|G12V(PATU8988S_PANCREAS)|G12V(CAPAN2_PANCREAS)|G12D(KP4_PANCREAS)|G12D(LS513_LARGE_INTESTINE)|G12D(SNUC2A_LARGE_INTESTINE)|G12V(SW480_LARGE_INTESTINE)|G12V(COLO668_LUNG)|G12D(COLO678_LARGE_INTESTINE)|G12V(RERFLCAD2_LUNG)|G12D(PANC0203_PANCREAS)|G12V(CFPAC1_PANCREAS)|G12V(SW900_LUNG)|G12V(LCLC97TM1_LUNG)|G12V(SW620_LARGE_INTESTINE)|G12A(MM1S_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12V(SH10TC_STOMACH)|G12V(A498_KIDNEY)|G12D(PK59_PANCREAS)|G12D(HEC1A_ENDOMETRIUM)|G12D(PANC0504_PANCREAS)|G12V(SNGM_ENDOMETRIUM)|G12A(RERFLCAD1_LUNG)|G12A(KPNSI9S_AUTONOMIC_GANGLIA)|G12D(ASPC1_PANCREAS)|G12A(RPMI8226_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12V(RCM1_LARGE_INTESTINE)|G12V(CORL23_LUNG)|G12D(SW1990_PANCREAS)|G12D(HEYA8_OVARY)|G12A(NCIH1573_LUNG)|G12A(NCIH2009_LUNG)|G12V(HUPT4_PANCREAS)|G12D(KARPAS620_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(HEC50B_ENDOMETRIUM)|G12V(YAPC_PANCREAS)|G12V(NCIH2444_LUNG)|G12V(HCC56_LARGE_INTESTINE)|G12D(MCAS_OVARY)|G12V(DANG_PANCREAS)|G12V(SHP77_LUNG)|G12D(AGS_STOMACH)|G12D(SKLU1_LUNG)|G12V(QGP1_PANCREAS)|G12D(L33_PANCREAS)|G12V(PANC0327_PANCREAS)|G12D(PANC1_PANCREAS)|G12V(RKN_OVARY)|G12V(PATU8902_PANCREAS)	119	Mis		pancreatic|colorectal|lung|thyroid|AML|others				Cardiofaciocutaneous_syndrome|Noonan_syndrome	TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)			7	18					0.00448238	0.00478939	0.004482	1	0
OR6C65	403282	broad.mit.edu	37	12	55794443	55794443	+	Missense_Mutation	SNP	T	T	A			TCGA-67-3773-01A-01D-1040-01	TCGA-67-3773-10A-01D-1489-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	593cee5f-98b3-4f51-bd9f-3bf3dbb6d1d1	2e4532d8-cebf-4bdf-95d0-5c02f94d186e	g.chr12:55794443T>A	uc010spl.1	+	1	131	c.131T>A	c.(130-132)ATT>AAT	p.I44N		NM_001005518	NP_001005518	A6NJZ3	O6C65_HUMAN	olfactory receptor, family 6, subfamily C,	44	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						ATGATCATCATTATGTTAACA	0.308			NA											11	25					0	0	0.008291	0	0
NAV3	89795	broad.mit.edu	37	12	78542638	78542638	+	Missense_Mutation	SNP	G	G	T			TCGA-67-3773-01A-01D-1040-01	TCGA-67-3773-10A-01D-1489-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	593cee5f-98b3-4f51-bd9f-3bf3dbb6d1d1	2e4532d8-cebf-4bdf-95d0-5c02f94d186e	g.chr12:78542638G>T	uc001syp.2	+	22	4897	c.4724G>T	c.(4723-4725)CGG>CTG	p.R1575L	NAV3_uc001syo.2_Missense_Mutation_p.R1575L|NAV3_uc010sub.1_Missense_Mutation_p.R1061L|NAV3_uc009zsf.2_Missense_Mutation_p.R406L	NM_014903	NP_055718	Q8IVL0	NAV3_HUMAN	neuron navigator 3	1575	Potential.					nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			large_intestine(6)|ovary(5)|lung(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	17						CATAAACTGCGGAGAGAGCTG	0.333			NA								HNSCC(70;0.22)			3	11					0.000602214	0.000652399	0.014758	1	0
TMTC2	160335	broad.mit.edu	37	12	83251161	83251161	+	Missense_Mutation	SNP	G	G	T			TCGA-67-3773-01A-01D-1040-01	TCGA-67-3773-10A-01D-1489-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	593cee5f-98b3-4f51-bd9f-3bf3dbb6d1d1	2e4532d8-cebf-4bdf-95d0-5c02f94d186e	g.chr12:83251161G>T	uc001szt.2	+	2	888	c.456G>T	c.(454-456)TTG>TTT	p.L152F	TMTC2_uc001szr.1_Missense_Mutation_p.L152F|TMTC2_uc001szs.1_Missense_Mutation_p.L152F|TMTC2_uc010suk.1_Intron	NM_152588	NP_689801	Q8N394	TMTC2_HUMAN	transmembrane and tetratricopeptide repeat	152	Helical; (Potential).					endoplasmic reticulum|integral to membrane	binding			ovary(2)	2						TCCTCTCCTTGCTCTGCTACA	0.557			NA											21	46					4.7796e-09	5.96495e-09	0.004656	1	0
SPATA13	221178	broad.mit.edu	37	13	24860373	24860373	+	Missense_Mutation	SNP	G	G	T			TCGA-67-3773-01A-01D-1040-01	TCGA-67-3773-10A-01D-1489-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	593cee5f-98b3-4f51-bd9f-3bf3dbb6d1d1	2e4532d8-cebf-4bdf-95d0-5c02f94d186e	g.chr13:24860373G>T	uc001upg.1	+	5	855	c.448G>T	c.(448-450)GTC>TTC	p.V150F	SPATA13_uc001upd.1_Missense_Mutation_p.V775F|C1QTNF9_uc001upe.2_RNA|SPATA13_uc010tcy.1_Missense_Mutation_p.V96F|SPATA13_uc010tcz.1_Missense_Mutation_p.V96F|SPATA13_uc010tda.1_Missense_Mutation_p.V94F|SPATA13_uc001uph.2_Missense_Mutation_p.V72F|SPATA13_uc010tdb.1_Missense_Mutation_p.V72F|SPATA13_uc009zzz.1_5'Flank	NM_153023	NP_694568	Q96N96	SPT13_HUMAN	spermatogenesis associated 13	150	SH3.|ABR (APC-binding region) domain.				cell migration|filopodium assembly|lamellipodium assembly|regulation of cell migration|regulation of Rho protein signal transduction	cytoplasm|filopodium|lamellipodium|ruffle membrane	protein binding|Rac guanyl-nucleotide exchange factor activity			skin(2)|ovary(1)	3		all_cancers(29;4.05e-15)|all_lung(29;2.77e-14)|all_epithelial(30;7.77e-13)|Lung SC(185;0.0279)		all cancers(112;0.00616)|Epithelial(112;0.0195)|OV - Ovarian serous cystadenocarcinoma(117;0.0705)|Lung(94;0.231)		TGGCAACGTGGTCTGCGCAGA	0.582			NA											173	263					4.26038e-92	7.14644e-92	0.01441	1	0
LOC220429	220429	broad.mit.edu	37	13	50466435	50466435	+	Missense_Mutation	SNP	C	C	T			TCGA-67-3773-01A-01D-1040-01	TCGA-67-3773-10A-01D-1489-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	593cee5f-98b3-4f51-bd9f-3bf3dbb6d1d1	2e4532d8-cebf-4bdf-95d0-5c02f94d186e	g.chr13:50466435C>T	uc001vdk.2	+	1	1891	c.1709C>T	c.(1708-1710)ACC>ATC	p.T570I		NR_003268				Homo sapiens CTAGE family, member 5 pseudogene, mRNA (cDNA clone IMAGE:5270026).												0						CACCAGATTACCAGTGAAAGA	0.562			NA											6	64					0	0	0.001168	0	0
ATP7B	540	broad.mit.edu	37	13	52534313	52534313	+	Missense_Mutation	SNP	T	T	C			TCGA-67-3773-01A-01D-1040-01	TCGA-67-3773-10A-01D-1489-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	593cee5f-98b3-4f51-bd9f-3bf3dbb6d1d1	2e4532d8-cebf-4bdf-95d0-5c02f94d186e	g.chr13:52534313T>C	uc001vfw.2	-	7	2249	c.2092A>G	c.(2092-2094)ATC>GTC	p.I698V	ATP7B_uc010adv.2_Intron|ATP7B_uc001vfx.2_Intron|ATP7B_uc001vfy.2_Missense_Mutation_p.I587V|ATP7B_uc010tgt.1_Missense_Mutation_p.I698V|ATP7B_uc010tgu.1_Missense_Mutation_p.I698V|ATP7B_uc010tgv.1_Missense_Mutation_p.I698V|ATP7B_uc001vfv.2_5'Flank|ATP7B_uc010tgs.1_Intron|ATP7B_uc010tgw.1_Intron	NM_000053	NP_000044	P35670	ATP7B_HUMAN	ATPase, Cu++ transporting, beta polypeptide	698	Helical; (Potential).				ATP biosynthetic process|cellular copper ion homeostasis|copper ion import|response to copper ion|sequestering of calcium ion	Golgi membrane|integral to plasma membrane|late endosome|mitochondrion	ATP binding|copper ion binding|copper-exporting ATPase activity|protein binding			ovary(1)|central_nervous_system(1)|skin(1)	3		Breast(56;0.000207)|Lung NSC(96;0.000845)|Prostate(109;0.0235)|Hepatocellular(98;0.065)|all_neural(104;0.19)		GBM - Glioblastoma multiforme(99;5.25e-08)		ATAAAGAAGATGAGATTTAGA	0.478			NA							Wilson_disease				25	73					0	0	0.004656	0	0
FCF1	51077	broad.mit.edu	37	14	75182766	75182766	+	Missense_Mutation	SNP	T	T	G			TCGA-67-3773-01A-01D-1040-01	TCGA-67-3773-10A-01D-1489-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	593cee5f-98b3-4f51-bd9f-3bf3dbb6d1d1	2e4532d8-cebf-4bdf-95d0-5c02f94d186e	g.chr14:75182766T>G	uc001xqh.2	+	4	307	c.256T>G	c.(256-258)TTA>GTA	p.L86V	KIAA0317_uc001xqb.2_5'Flank|KIAA0317_uc010tut.1_5'Flank|KIAA0317_uc001xqc.2_5'Flank|KIAA0317_uc001xqd.1_5'Flank|FCF1_uc001xqf.1_Missense_Mutation_p.L71V|FCF1_uc001xqg.2_RNA|FCF1_uc001xqi.2_RNA	NM_015962	NP_057046	Q9Y324	FCF1_HUMAN	FCF1 small subunit	86	PINc.				rRNA processing	nucleolus				ovary(1)	1				BRCA - Breast invasive adenocarcinoma(234;0.0037)		CAAACTGGACTTAGTGCAGTC	0.358			NA											108	62					0	0	0.01441	0	0
GOLGA8DP	100132979	broad.mit.edu	37	15	22709152	22709152	+	Missense_Mutation	SNP	G	G	T			TCGA-67-3773-01A-01D-1040-01	TCGA-67-3773-10A-01D-1489-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	593cee5f-98b3-4f51-bd9f-3bf3dbb6d1d1	2e4532d8-cebf-4bdf-95d0-5c02f94d186e	g.chr15:22709152G>T	uc010axw.2	-	11	1245	c.347C>A	c.(346-348)GCG>GAG	p.A116E	GOLGA8DP_uc010axx.2_Missense_Mutation_p.A116E|uc010tzw.1_5'Flank	NM_001012423	NP_001012423			golgi autoantigen, golgin subfamily a, 8E												0						GGCCTGGAGCGCTCCTGCCAC	0.607			NA											6	112					0.00116845	0.00125709	0.001168	1	0
Unknown	0	broad.mit.edu	37	15	28600154	28600154	+	Splice_Site	SNP	T	T	A			TCGA-67-3773-01A-01D-1040-01	TCGA-67-3773-10A-01D-1489-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	593cee5f-98b3-4f51-bd9f-3bf3dbb6d1d1	2e4532d8-cebf-4bdf-95d0-5c02f94d186e	g.chr15:28600154T>A	uc010uaf.1	-	3	196	c.178_splice	c.e3-1	p.E60_splice						SubName: Full=Putative uncharacterized protein ENSP00000383535; Flags: Fragment;												NA						CTTCTGTTCCTATAGAAAGAG	0.557			NA											11	56					0	0	0.020292	0	0
THSD4	79875	broad.mit.edu	37	15	72037537	72037537	+	Missense_Mutation	SNP	G	G	A			TCGA-67-3773-01A-01D-1040-01	TCGA-67-3773-10A-01D-1489-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	593cee5f-98b3-4f51-bd9f-3bf3dbb6d1d1	2e4532d8-cebf-4bdf-95d0-5c02f94d186e	g.chr15:72037537G>A	uc002atb.1	+	11	2078	c.1999G>A	c.(1999-2001)GAG>AAG	p.E667K	THSD4_uc002ate.2_Missense_Mutation_p.E307K	NM_024817	NP_079093	Q6ZMP0	THSD4_HUMAN	thrombospondin, type I, domain containing 4	667						proteinaceous extracellular matrix	metalloendopeptidase activity			ovary(2)	2						GCCGACCCCCGAGGAGGAGCC	0.547			NA											186	399					0	0	0.01441	0	0
WASH3P	374666	broad.mit.edu	37	15	102515299	102515299	+	Missense_Mutation	SNP	G	G	A			TCGA-67-3773-01A-01D-1040-01	TCGA-67-3773-10A-01D-1489-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	593cee5f-98b3-4f51-bd9f-3bf3dbb6d1d1	2e4532d8-cebf-4bdf-95d0-5c02f94d186e	g.chr15:102515299G>A	uc002cdi.2	+	9	1943	c.523G>A	c.(523-525)GGC>AGC	p.G175S	WASH3P_uc002cdl.2_Missense_Mutation_p.G175S|WASH3P_uc002cdk.2_RNA|WASH3P_uc002cdp.2_Missense_Mutation_p.G175S|WASH3P_uc010bpo.2_RNA|WASH3P_uc002cdq.2_RNA|WASH3P_uc002cdr.2_RNA	NR_003659				RecName: Full=WAS protein family homolog 2; AltName: Full=Protein FAM39B; AltName: Full=CXYorf1-like protein on chromosome 2;												0						TGGGGGCATCGGCAAGGCCAA	0.652			NA											8	28					0	0	0.006214	0	0
C16orf11	146325	broad.mit.edu	37	16	613967	613967	+	Missense_Mutation	SNP	C	C	G			TCGA-67-3773-01A-01D-1040-01	TCGA-67-3773-10A-01D-1489-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	593cee5f-98b3-4f51-bd9f-3bf3dbb6d1d1	2e4532d8-cebf-4bdf-95d0-5c02f94d186e	g.chr16:613967C>G	uc002chk.2	+	2	952	c.673C>G	c.(673-675)CCC>GCC	p.P225A		NM_145270	NP_660313	P0CG20	CP011_HUMAN	hypothetical protein LOC146325	225	Pro-rich.									central_nervous_system(1)	1						CTACTTGGGGCCCTCACTGGC	0.731			NA											3	14					0	0	0.004672	0	0
OR1F2P	26184	broad.mit.edu	37	16	3266457	3266457	+	Missense_Mutation	SNP	G	G	A			TCGA-67-3773-01A-01D-1040-01	TCGA-67-3773-10A-01D-1489-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	593cee5f-98b3-4f51-bd9f-3bf3dbb6d1d1	2e4532d8-cebf-4bdf-95d0-5c02f94d186e	g.chr16:3266457G>A	uc010uwv.1	+	1	896	c.748G>A	c.(748-750)GTG>ATG	p.V250M		NR_002169				RecName: Full=Olfactory receptor 1F2; AltName: Full=OLFmf2;												0						GGTGACTCCCGTGATGAATCC	0.433			NA											5	18					0	0	0.00308	0	0
SH2B1	25970	broad.mit.edu	37	16	28877650	28877650	+	Missense_Mutation	SNP	G	G	A			TCGA-67-3773-01A-01D-1040-01	TCGA-67-3773-10A-01D-1489-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	593cee5f-98b3-4f51-bd9f-3bf3dbb6d1d1	2e4532d8-cebf-4bdf-95d0-5c02f94d186e	g.chr16:28877650G>A	uc002dri.2	+	4	674	c.235G>A	c.(235-237)GAG>AAG	p.E79K	uc010vct.1_Intron|SH2B1_uc010vdc.1_Intron|SH2B1_uc002drj.2_Missense_Mutation_p.E79K|SH2B1_uc002drk.2_Missense_Mutation_p.E79K|SH2B1_uc002drl.2_Missense_Mutation_p.E79K|SH2B1_uc010vdd.1_Intron|SH2B1_uc010vde.1_Missense_Mutation_p.E79K|SH2B1_uc002drm.2_Missense_Mutation_p.E79K	NM_001145795	NP_001139267	Q9NRF2	SH2B1_HUMAN	SH2B adaptor protein 1 isoform 1	79	Interaction with JAK2 (low-affinity binding; independent of JAK2 phosphorylation) (By similarity).|Required for self-association.				blood coagulation|intracellular signal transduction	cytosol|membrane|nucleus	signal transducer activity			ovary(2)	2						CTTTGAAGCCGAGGTGGCCCG	0.667			NA											5	49					0	0	0.001984	0	0
LAT	27040	broad.mit.edu	37	16	28996766	28996766	+	Missense_Mutation	SNP	G	G	A			TCGA-67-3773-01A-01D-1040-01	TCGA-67-3773-10A-01D-1489-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	593cee5f-98b3-4f51-bd9f-3bf3dbb6d1d1	2e4532d8-cebf-4bdf-95d0-5c02f94d186e	g.chr16:28996766G>A	uc002dsd.2	+	1	380	c.28G>A	c.(28-30)GTG>ATG	p.V10M	uc010vct.1_Intron|SPNS1_uc010byq.1_3'UTR|LAT_uc010vdj.1_Missense_Mutation_p.V46M|LAT_uc002dsb.2_Missense_Mutation_p.V10M|LAT_uc002dsc.2_Missense_Mutation_p.V10M|LAT_uc010vdk.1_Missense_Mutation_p.V10M|LAT_uc010vdl.1_Missense_Mutation_p.V10M	NM_014387	NP_055202	O43561	LAT_HUMAN	linker for activation of T cells isoform a	10	Helical; Signal-anchor for type III membrane protein; (Potential).				calcium-mediated signaling|integrin-mediated signaling pathway|mast cell degranulation|platelet activation|Ras protein signal transduction|regulation of T cell activation|T cell receptor signaling pathway	immunological synapse|integral to membrane|intracellular|membrane raft	SH3/SH2 adaptor activity				0		Hepatocellular(780;0.244)				GGTCCCCTGCGTGCTGGGGCT	0.637			NA											38	95					0	0	0.00623	0	0
TAOK2	9344	broad.mit.edu	37	16	29996668	29996668	+	Missense_Mutation	SNP	G	G	T			TCGA-67-3773-01A-01D-1040-01	TCGA-67-3773-10A-01D-1489-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	593cee5f-98b3-4f51-bd9f-3bf3dbb6d1d1	2e4532d8-cebf-4bdf-95d0-5c02f94d186e	g.chr16:29996668G>T	uc002dva.1	+	14	2340	c.1557G>T	c.(1555-1557)GAG>GAT	p.E519D	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|TAOK2_uc002dvb.1_Missense_Mutation_p.E519D|TAOK2_uc002dvc.1_Missense_Mutation_p.E519D|TAOK2_uc010bzm.1_Missense_Mutation_p.E526D|TAOK2_uc002dvd.1_Missense_Mutation_p.E346D	NM_016151	NP_057235	Q9UL54	TAOK2_HUMAN	TAO kinase 2 isoform 2	519	Potential.				actin cytoskeleton organization|activation of MAPKK activity|apoptosis|cell migration|focal adhesion assembly|positive regulation of JNK cascade|protein targeting to membrane|regulation of cell growth|regulation of cell shape|response to stress	cytoplasmic vesicle membrane|cytoskeleton|dendrite|integral to membrane|nucleolus	ATP binding|protein serine/threonine kinase activity			ovary(1)	1						AACGGGAGGAGCACAGTGCAC	0.672			NA											33	53					3.11337e-16	4.4971e-16	0.013726	1	0
GLG1	2734	broad.mit.edu	37	16	74526922	74526922	+	Silent	SNP	G	G	A			TCGA-67-3773-01A-01D-1040-01	TCGA-67-3773-10A-01D-1489-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	593cee5f-98b3-4f51-bd9f-3bf3dbb6d1d1	2e4532d8-cebf-4bdf-95d0-5c02f94d186e	g.chr16:74526922G>A	uc002fcy.3	-	7	1217	c.1167C>T	c.(1165-1167)AAC>AAT	p.N389N	GLG1_uc002fcx.2_Silent_p.N389N|GLG1_uc002fcw.3_Silent_p.N378N|GLG1_uc002fcz.3_Intron	NM_001145667	NP_001139139	Q92896	GSLG1_HUMAN	golgi apparatus protein 1 isoform 3	389	Cys-rich GLG1 5.|Extracellular (Potential).					Golgi membrane|integral to membrane	receptor binding			ovary(1)|breast(1)	2						ATCGCGGAAGGTTTTCCACAT	0.418			NA											13	144					0	0	0.020292	0	0
MTHFSD	64779	broad.mit.edu	37	16	86565744	86565744	+	Missense_Mutation	SNP	C	C	T			TCGA-67-3773-01A-01D-1040-01	TCGA-67-3773-10A-01D-1489-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	593cee5f-98b3-4f51-bd9f-3bf3dbb6d1d1	2e4532d8-cebf-4bdf-95d0-5c02f94d186e	g.chr16:86565744C>T	uc002fjn.2	-	8	1076	c.1025G>A	c.(1024-1026)CGG>CAG	p.R342Q	MTHFSD_uc010voo.1_Missense_Mutation_p.R322Q|MTHFSD_uc002fjo.2_Missense_Mutation_p.R179Q|MTHFSD_uc002fjm.2_Missense_Mutation_p.R341Q|MTHFSD_uc010vop.1_Missense_Mutation_p.R179Q|MTHFSD_uc010voq.1_Missense_Mutation_p.R341Q|MTHFSD_uc010vor.1_Missense_Mutation_p.R342Q	NM_001159377	NP_001152849	Q2M296	MTHSD_HUMAN	methenyltetrahydrofolate synthetase domain	342	RRM.				folic acid-containing compound biosynthetic process		5-formyltetrahydrofolate cyclo-ligase activity|ATP binding|RNA binding				0						GGCTCTGCGCCGCGGGCCCTG	0.711			NA											7	17					0	0	0.004482	0	0
ZNF287	57336	broad.mit.edu	37	17	16470691	16470691	+	Missense_Mutation	SNP	C	C	T			TCGA-67-3773-01A-01D-1040-01	TCGA-67-3773-10A-01D-1489-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	593cee5f-98b3-4f51-bd9f-3bf3dbb6d1d1	2e4532d8-cebf-4bdf-95d0-5c02f94d186e	g.chr17:16470691C>T	uc002gqi.2	-	2	808	c.355G>A	c.(355-357)GAA>AAA	p.E119K		NM_020653	NP_065704	Q9HBT7	ZN287_HUMAN	zinc finger protein 287	112	SCAN box.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0				UCEC - Uterine corpus endometrioid carcinoma (92;0.083)		GTCACTGCTTCCTCGCTGCTC	0.507			NA											48	44					0	0	0.01441	0	0
GSDMB	55876	broad.mit.edu	37	17	38066035	38066035	+	Nonsense_Mutation	SNP	G	G	A			TCGA-67-3773-01A-01D-1040-01	TCGA-67-3773-10A-01D-1489-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	593cee5f-98b3-4f51-bd9f-3bf3dbb6d1d1	2e4532d8-cebf-4bdf-95d0-5c02f94d186e	g.chr17:38066035G>A	uc010cwj.2	-	3	555	c.550C>T	c.(550-552)CAG>TAG	p.Q184*	GSDMB_uc010cwi.2_5'Flank|GSDMB_uc010cwk.2_RNA|GSDMB_uc010cwl.2_RNA|GSDMB_uc010cwm.2_Intron|GSDMB_uc002htg.2_Nonsense_Mutation_p.Q184*|GSDMB_uc002hth.2_Nonsense_Mutation_p.Q184*|GSDMB_uc010wem.1_Nonsense_Mutation_p.Q184*	NM_001042471	NP_001035936	Q8TAX9	GSDMB_HUMAN	gasdermin B isoform 1	184						cytoplasm				breast(1)|pancreas(1)	2						AGATGGCCCTGAGAGATCTGG	0.532			NA											63	143					0	0	0.01441	0	0
KIF2B	84643	broad.mit.edu	37	17	51902309	51902309	+	Missense_Mutation	SNP	G	G	T			TCGA-67-3773-01A-01D-1040-01	TCGA-67-3773-10A-01D-1489-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	593cee5f-98b3-4f51-bd9f-3bf3dbb6d1d1	2e4532d8-cebf-4bdf-95d0-5c02f94d186e	g.chr17:51902309G>T	uc002iua.2	+	1	2071	c.1915G>T	c.(1915-1917)GCC>TCC	p.A639S	uc010wna.1_RNA	NM_032559	NP_115948	Q8N4N8	KIF2B_HUMAN	kinesin family member 2B	639					blood coagulation|cell division|microtubule depolymerization|microtubule-based movement|mitotic prometaphase|regulation of chromosome segregation	condensed chromosome kinetochore|cytosol|microtubule|microtubule organizing center|nucleolus|spindle	ATP binding|microtubule motor activity			ovary(5)|skin(3)	8						TTTTTGCATTGCCCGGTCTTT	0.448			NA											32	79					1.39806e-14	1.96483e-14	0.008361	1	0
PTPRM	5797	broad.mit.edu	37	18	7926632	7926632	+	Missense_Mutation	SNP	A	A	G			TCGA-67-3773-01A-01D-1040-01	TCGA-67-3773-10A-01D-1489-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	593cee5f-98b3-4f51-bd9f-3bf3dbb6d1d1	2e4532d8-cebf-4bdf-95d0-5c02f94d186e	g.chr18:7926632A>G	uc002knn.3	+	5	1117	c.614A>G	c.(613-615)CAG>CGG	p.Q205R	PTPRM_uc010dkv.2_Missense_Mutation_p.Q205R	NM_002845	NP_002836	P28827	PTPRM_HUMAN	protein tyrosine phosphatase, receptor type, M	205	Ig-like C2-type.|Extracellular (Potential).				homophilic cell adhesion|negative regulation of angiogenesis|negative regulation of endothelial cell migration|negative regulation of endothelial cell proliferation|response to drug|retina layer formation|retinal ganglion cell axon guidance	cell-cell adherens junction|integral to plasma membrane|lamellipodium|perinuclear region of cytoplasm	cadherin binding|transmembrane receptor protein tyrosine phosphatase activity			lung(3)|ovary(2)|central_nervous_system(1)	6		Colorectal(10;0.234)				GCTACCTTCCAGTGCAGTGCC	0.463			NA											36	75					0	0	0.01441	0	0
ASXL3	80816	broad.mit.edu	37	18	31323885	31323885	+	Missense_Mutation	SNP	T	T	C			TCGA-67-3773-01A-01D-1040-01	TCGA-67-3773-10A-01D-1489-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	593cee5f-98b3-4f51-bd9f-3bf3dbb6d1d1	2e4532d8-cebf-4bdf-95d0-5c02f94d186e	g.chr18:31323885T>C	uc010dmg.1	+	12	4128	c.4073T>C	c.(4072-4074)GTC>GCC	p.V1358A	ASXL3_uc002kxq.2_Missense_Mutation_p.V1065A	NM_030632	NP_085135	Q9C0F0	ASXL3_HUMAN	additional sex combs like 3	1358					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding			ovary(2)|pancreas(1)	3						ACTAGCTCTGTCTTGATTCCC	0.473			NA									OREG0024911	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	142	319					0	0	0.01441	0	0
NOL4	8715	broad.mit.edu	37	18	31523045	31523045	+	Missense_Mutation	SNP	C	C	A			TCGA-67-3773-01A-01D-1040-01	TCGA-67-3773-10A-01D-1489-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	593cee5f-98b3-4f51-bd9f-3bf3dbb6d1d1	2e4532d8-cebf-4bdf-95d0-5c02f94d186e	g.chr18:31523045C>A	uc010dmi.2	-	9	1755	c.1526G>T	c.(1525-1527)CGT>CTT	p.R509L	NOL4_uc010xbs.1_Missense_Mutation_p.R224L|NOL4_uc002kxr.3_Missense_Mutation_p.R281L|NOL4_uc010xbt.1_Missense_Mutation_p.R435L|NOL4_uc010dmh.2_Missense_Mutation_p.R371L|NOL4_uc010xbu.1_Missense_Mutation_p.R445L|NOL4_uc002kxt.3_Intron|NOL4_uc010xbv.1_Missense_Mutation_p.R194L	NM_003787	NP_003778	O94818	NOL4_HUMAN	nucleolar protein 4	509						nucleolus	RNA binding			ovary(3)	3						TCTCTCCAGACGCATCCTCTT	0.443			NA											17	30					5.3912e-06	6.22984e-06	0.006122	1	0
SETBP1	26040	broad.mit.edu	37	18	42532619	42532619	+	Missense_Mutation	SNP	G	G	T			TCGA-67-3773-01A-01D-1040-01	TCGA-67-3773-10A-01D-1489-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	593cee5f-98b3-4f51-bd9f-3bf3dbb6d1d1	2e4532d8-cebf-4bdf-95d0-5c02f94d186e	g.chr18:42532619G>T	uc010dni.2	+	4	3610	c.3314G>T	c.(3313-3315)GGT>GTT	p.G1105V		NM_015559	NP_056374	Q9Y6X0	SETBP_HUMAN	SET binding protein 1 isoform a	1105						nucleus	DNA binding			upper_aerodigestive_tract(2)|large_intestine(1)	3				Colorectal(1;0.0622)|COAD - Colon adenocarcinoma(74;0.201)		AAGATGTCCGGTGCAGCTAAG	0.547			NA							Schinzel-Giedion_syndrome				59	137					7.50695e-29	1.18291e-28	0.01441	1	0
CDH20	28316	broad.mit.edu	37	18	59157904	59157904	+	Missense_Mutation	SNP	C	C	A			TCGA-67-3773-01A-01D-1040-01	TCGA-67-3773-10A-01D-1489-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	593cee5f-98b3-4f51-bd9f-3bf3dbb6d1d1	2e4532d8-cebf-4bdf-95d0-5c02f94d186e	g.chr18:59157904C>A	uc010dps.1	+	1	130	c.118C>A	c.(118-120)CAA>AAA	p.Q40K	CDH20_uc002lif.2_Missense_Mutation_p.Q34K	NM_031891	NP_114097	Q9HBT6	CAD20_HUMAN	cadherin 20, type 2 preproprotein	40					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(3)|ovary(1)|pancreas(1)	5		Colorectal(73;0.186)				CCCAACACCACAAGGTGAATT	0.512			NA											13	110					0.00010058	0.00011128	0.013537	1	0
ANKRD24	170961	broad.mit.edu	37	19	4216959	4216959	+	Missense_Mutation	SNP	C	C	A			TCGA-67-3773-01A-01D-1040-01	TCGA-67-3773-10A-01D-1489-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	593cee5f-98b3-4f51-bd9f-3bf3dbb6d1d1	2e4532d8-cebf-4bdf-95d0-5c02f94d186e	g.chr19:4216959C>A	uc010dtt.1	+	18	2078	c.1802C>A	c.(1801-1803)CCC>CAC	p.P601H	ANKRD24_uc002lzs.2_Missense_Mutation_p.P572H|ANKRD24_uc002lzt.2_Missense_Mutation_p.P573H	NM_133475	NP_597732	Q8TF21	ANR24_HUMAN	ankyrin repeat domain 24	601											0				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0233)|STAD - Stomach adenocarcinoma(1328;0.181)		GAAACAAAACCCACAGGGGCT	0.567			NA											20	23					1.56452e-12	2.10402e-12	0.007413	1	0
STAP2	55620	broad.mit.edu	37	19	4327149	4327149	+	Silent	SNP	C	C	A			TCGA-67-3773-01A-01D-1040-01	TCGA-67-3773-10A-01D-1489-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	593cee5f-98b3-4f51-bd9f-3bf3dbb6d1d1	2e4532d8-cebf-4bdf-95d0-5c02f94d186e	g.chr19:4327149C>A	uc002mab.2	-	8	832	c.735G>T	c.(733-735)CTG>CTT	p.L245L	STAP2_uc002mac.2_Silent_p.L245L|STAP2_uc002mad.2_Silent_p.L138L	NM_001013841	NP_001013863	Q9UGK3	STAP2_HUMAN	signal transducing adaptor family member 2	245	SH2.					cytoplasm|nucleus	protein binding			central_nervous_system(1)	1		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0339)|STAD - Stomach adenocarcinoma(1328;0.18)		CCTCGTCTAACAGGAATGGCA	0.647			NA											26	86					9.04412e-07	1.06885e-06	0.004656	1	0
EMR3	84658	broad.mit.edu	37	19	14758015	14758015	+	Missense_Mutation	SNP	G	G	A			TCGA-67-3773-01A-01D-1040-01	TCGA-67-3773-10A-01D-1489-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	593cee5f-98b3-4f51-bd9f-3bf3dbb6d1d1	2e4532d8-cebf-4bdf-95d0-5c02f94d186e	g.chr19:14758015G>A	uc002mzi.3	-	8	1008	c.860C>T	c.(859-861)ACG>ATG	p.T287M	EMR3_uc010dzp.2_Missense_Mutation_p.T235M|EMR3_uc010xnv.1_Missense_Mutation_p.T161M	NM_032571	NP_115960	Q9BY15	EMR3_HUMAN	egf-like module-containing mucin-like receptor	287	Extracellular (Potential).				neuropeptide signaling pathway	extracellular space|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(5)|skin(1)	6						GAAAGTCAGCGTCACAGACTT	0.483			NA											16	479					0	0	0.004007	0	0
CYP4F3	4051	broad.mit.edu	37	19	15758117	15758117	+	Missense_Mutation	SNP	A	A	T			TCGA-67-3773-01A-01D-1040-01	TCGA-67-3773-10A-01D-1489-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	593cee5f-98b3-4f51-bd9f-3bf3dbb6d1d1	2e4532d8-cebf-4bdf-95d0-5c02f94d186e	g.chr19:15758117A>T	uc002nbj.2	+	5	558	c.508A>T	c.(508-510)AGT>TGT	p.S170C	CYP4F3_uc010xok.1_Missense_Mutation_p.S170C|CYP4F3_uc010xol.1_Missense_Mutation_p.S170C|CYP4F3_uc010xom.1_Missense_Mutation_p.S21C|CYP4F3_uc002nbk.2_Missense_Mutation_p.S170C|CYP4F3_uc010xon.1_5'Flank	NM_000896	NP_000887	Q08477	CP4F3_HUMAN	cytochrome P450, family 4, subfamily F,	170					leukotriene metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	electron carrier activity|heme binding|leukotriene-B4 20-monooxygenase activity|oxygen binding			ovary(3)	3						TTTCAATGAGAGTGTGAACAT	0.438			NA											77	146					0	0	0.01441	0	0
CYP4F12	66002	broad.mit.edu	37	19	15789113	15789113	+	Missense_Mutation	SNP	T	T	A			TCGA-67-3773-01A-01D-1040-01	TCGA-67-3773-10A-01D-1489-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	593cee5f-98b3-4f51-bd9f-3bf3dbb6d1d1	2e4532d8-cebf-4bdf-95d0-5c02f94d186e	g.chr19:15789113T>A	uc002nbl.2	+	3	302	c.241T>A	c.(241-243)TCG>ACG	p.S81T	CYP4F12_uc010xoo.1_Missense_Mutation_p.S81T|CYP4F12_uc010xop.1_Missense_Mutation_p.S81T	NM_023944	NP_076433			cytochrome P450, family 4, subfamily F,											skin(3)|ovary(2)|central_nervous_system(2)	7	Acute lymphoblastic leukemia(2;0.0367)					GACCCAGATGTCGGCCACCTA	0.458			NA											50	188					0	0	0.01441	0	0
ZNF43	7594	broad.mit.edu	37	19	21991490	21991491	+	Missense_Mutation	DNP	CC	CC	AA			TCGA-67-3773-01A-01D-1040-01	TCGA-67-3773-10A-01D-1489-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	593cee5f-98b3-4f51-bd9f-3bf3dbb6d1d1	2e4532d8-cebf-4bdf-95d0-5c02f94d186e	g.chr19:21991490_21991491CC>AA	uc002nqj.2	-	4	1478_1479	c.1348_1349GG>TT	c.(1348-1350)GGA>TTA	p.G450L	ZNF43_uc010ecv.2_Missense_Mutation_p.G444L|ZNF43_uc002nql.2_Missense_Mutation_p.G444L|ZNF43_uc002nqm.2_Missense_Mutation_p.G444L|ZNF43_uc002nqk.2_Missense_Mutation_p.G380L	NM_003423	NP_003414	P17038	ZNF43_HUMAN	zinc finger protein 43	450					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)|ovary(1)	2		Renal(1328;0.000219)|Hepatocellular(1079;0.121)		GBM - Glioblastoma multiforme(1328;5.97e-05)|STAD - Stomach adenocarcinoma(1328;0.0127)		GGGTTTCTCTCCAGTATGAATT	0.381			NA											20	36					0	0	0.004672	0	0
PAF1	54623	broad.mit.edu	37	19	39879075	39879075	+	Missense_Mutation	SNP	C	C	A			TCGA-67-3773-01A-01D-1040-01	TCGA-67-3773-10A-01D-1489-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	593cee5f-98b3-4f51-bd9f-3bf3dbb6d1d1	2e4532d8-cebf-4bdf-95d0-5c02f94d186e	g.chr19:39879075C>A	uc002old.2	-	11	1065	c.890G>T	c.(889-891)TGG>TTG	p.W297L	PAF1_uc002ole.1_Missense_Mutation_p.W287L|PAF1_uc010xuv.1_RNA|MED29_uc010xuw.1_5'Flank|MED29_uc002olf.2_5'Flank|MED29_uc010xux.1_5'Flank	NM_019088	NP_061961	Q8N7H5	PAF1_HUMAN	Paf1, RNA polymerase II associated factor,	297					histone H2B ubiquitination|histone monoubiquitination|regulation of transcription, DNA-dependent|transcription, DNA-dependent	Cdc73/Paf1 complex	protein binding			pancreas(1)	1	all_cancers(60;9.14e-07)|all_lung(34;4.03e-08)|Lung NSC(34;4.66e-08)|all_epithelial(25;1.88e-06)|Ovarian(47;0.0512)		Epithelial(26;9.6e-28)|all cancers(26;9.14e-25)|Lung(45;0.000168)|LUSC - Lung squamous cell carcinoma(53;0.000199)			CTTCACGTTCCAGTTGTACTC	0.478			NA											87	196					4.3955e-51	7.14269e-51	0.01441	1	0
LILRB1	10859	broad.mit.edu	37	19	55144063	55144063	+	Silent	SNP	C	C	T			TCGA-67-3773-01A-01D-1040-01	TCGA-67-3773-10A-01D-1489-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	593cee5f-98b3-4f51-bd9f-3bf3dbb6d1d1	2e4532d8-cebf-4bdf-95d0-5c02f94d186e	g.chr19:55144063C>T	uc002qgj.2	+	7	1150	c.810C>T	c.(808-810)GGC>GGT	p.G270G	LILRB1_uc010erp.1_Intron|LILRB1_uc002qgl.2_Silent_p.G270G|LILRB1_uc002qgk.2_Silent_p.G270G|LILRB1_uc002qgm.2_Silent_p.G270G|LILRB1_uc010erq.2_Silent_p.G270G|LILRB1_uc010err.2_RNA	NM_006669	NP_006660	Q8NHL6	LIRB1_HUMAN	leukocyte immunoglobulin-like receptor,	270	Ig-like C2-type 3.|Extracellular (Potential).				regulation of immune response|response to virus	integral to membrane|plasma membrane	protein phosphatase 1 binding|receptor activity			large_intestine(1)|ovary(1)|skin(1)	3				GBM - Glioblastoma multiforme(193;0.0188)		AGCTCGCTGGCGCACAGCCCC	0.607			NA								HNSCC(37;0.09)			86	167					0	0	0.01441	0	0
ZSCAN1	284312	broad.mit.edu	37	19	58551855	58551855	+	Missense_Mutation	SNP	G	G	T			TCGA-67-3773-01A-01D-1040-01	TCGA-67-3773-10A-01D-1489-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	593cee5f-98b3-4f51-bd9f-3bf3dbb6d1d1	2e4532d8-cebf-4bdf-95d0-5c02f94d186e	g.chr19:58551855G>T	uc002qrc.1	+	4	655	c.408G>T	c.(406-408)TGG>TGT	p.W136C		NM_182572	NP_872378	Q8NBB4	ZSCA1_HUMAN	zinc finger and SCAN domain containing 1	136					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2		Colorectal(82;5.46e-05)|all_neural(62;0.0182)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0152)		CCCAGGACTGGAGTTTCGGTG	0.622			NA											160	343					7.80376e-85	1.29509e-84	0.01441	1	0
LTBP1	4052	broad.mit.edu	37	2	33572578	33572578	+	Splice_Site	SNP	G	G	A			TCGA-67-3773-01A-01D-1040-01	TCGA-67-3773-10A-01D-1489-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	593cee5f-98b3-4f51-bd9f-3bf3dbb6d1d1	2e4532d8-cebf-4bdf-95d0-5c02f94d186e	g.chr2:33572578G>A	uc002ros.2	+	26	4003	c.4003_splice	c.e26+1	p.D1335_splice	LTBP1_uc002rot.2_Splice_Site_p.D1009_splice|LTBP1_uc002rou.2_Splice_Site_p.D1008_splice|LTBP1_uc002rov.2_Splice_Site_p.D955_splice|LTBP1_uc010ymz.1_Splice_Site_p.D966_splice|LTBP1_uc010yna.1_Splice_Site_p.D913_splice|LTBP1_uc010ynb.1_Splice_Site_p.D232_splice	NM_206943	NP_996826	Q14766	LTBP1_HUMAN	latent transforming growth factor beta binding						negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta	proteinaceous extracellular matrix	calcium ion binding|growth factor binding|transforming growth factor beta receptor activity			ovary(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|central_nervous_system(1)	8	all_hematologic(175;0.115)	Medulloblastoma(90;0.215)				ACCTCCACAGGTAAGTCCCAG	0.547			NA											87	157					0	0	0.01441	0	0
MYADML	151325	broad.mit.edu	37	2	33952372	33952372	+	Silent	SNP	G	G	A			TCGA-67-3773-01A-01D-1040-01	TCGA-67-3773-10A-01D-1489-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	593cee5f-98b3-4f51-bd9f-3bf3dbb6d1d1	2e4532d8-cebf-4bdf-95d0-5c02f94d186e	g.chr2:33952372G>A	uc002rpb.2	-	1	913	c.471C>T	c.(469-471)ATC>ATT	p.I157I		NR_003143				RecName: Full=Myeloid-associated differentiation marker-like protein.;												0						TGGGGAAGCGGATGGGCAGCA	0.632			NA											14	27					0	0	0.016723	0	0
PPM1B	5495	broad.mit.edu	37	2	44429147	44429147	+	Missense_Mutation	SNP	A	A	G			TCGA-67-3773-01A-01D-1040-01	TCGA-67-3773-10A-01D-1489-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	593cee5f-98b3-4f51-bd9f-3bf3dbb6d1d1	2e4532d8-cebf-4bdf-95d0-5c02f94d186e	g.chr2:44429147A>G	uc002rtt.2	+	2	1237	c.809A>G	c.(808-810)AAT>AGT	p.N270S	PPM1B_uc002rts.2_Missense_Mutation_p.N270S|PPM1B_uc002rtu.2_Missense_Mutation_p.N270S|PPM1B_uc002rtv.2_Intron|PPM1B_uc002rtw.2_Missense_Mutation_p.N270S|PPM1B_uc002rtx.2_Missense_Mutation_p.N270S	NM_002706	NP_002697	O75688	PPM1B_HUMAN	protein phosphatase 1B isoform 1	270					protein dephosphorylation	protein serine/threonine phosphatase complex	magnesium ion binding|manganese ion binding|protein binding|protein serine/threonine phosphatase activity			kidney(1)|skin(1)	2		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)				GACCTGGAAAATGTGTGCAAT	0.353			NA											15	44					0	0	0.008871	0	0
MYO7B	4648	broad.mit.edu	37	2	128391816	128391816	+	Silent	SNP	G	G	A			TCGA-67-3773-01A-01D-1040-01	TCGA-67-3773-10A-01D-1489-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	593cee5f-98b3-4f51-bd9f-3bf3dbb6d1d1	2e4532d8-cebf-4bdf-95d0-5c02f94d186e	g.chr2:128391816G>A	uc002top.2	+	40	5552	c.5499G>A	c.(5497-5499)CAG>CAA	p.Q1833Q	MYO7B_uc002tos.1_5'UTR|MYO7B_uc002tot.2_5'UTR	NM_001080527	NP_001073996	Q6PIF6	MYO7B_HUMAN	myosin VIIB	1833	FERM 2.|MyTH4 3.					apical plasma membrane|myosin complex	actin binding|ATP binding|motor activity			ovary(1)|pancreas(1)	2	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0753)		CCAGGCTGCAGCTGGCCTCCT	0.662			NA											7	12					0	0	0.00308	0	0
WIPF1	7456	broad.mit.edu	37	2	175437101	175437101	+	Silent	SNP	T	T	A			TCGA-67-3773-01A-01D-1040-01	TCGA-67-3773-10A-01D-1489-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	593cee5f-98b3-4f51-bd9f-3bf3dbb6d1d1	2e4532d8-cebf-4bdf-95d0-5c02f94d186e	g.chr2:175437101T>A	uc002uiy.2	-	6	764	c.432A>T	c.(430-432)CCA>CCT	p.P144P	uc002uiw.2_Intron|uc002uix.1_Intron|WIPF1_uc002uja.2_Silent_p.P144P|WIPF1_uc010fqt.1_Silent_p.P144P|WIPF1_uc002ujc.1_Silent_p.P144P|WIPF1_uc002uiz.2_Silent_p.P144P|WIPF1_uc002ujb.1_Silent_p.P144P|WIPF1_uc010zep.1_Silent_p.P144P	NM_003387	NP_003378	O43516	WIPF1_HUMAN	WAS/WASL interacting protein family, member 1	144					actin polymerization or depolymerization|protein complex assembly	cytoplasmic membrane-bounded vesicle	actin binding|profilin binding			ovary(1)|skin(1)	2						CTGGGCCACTTGGGGGTGAAA	0.582			NA											43	111					0	0	0.009718	0	0
TRPM8	79054	broad.mit.edu	37	2	234835266	234835266	+	Silent	SNP	G	G	A	rs149381224		TCGA-67-3773-01A-01D-1040-01	TCGA-67-3773-10A-01D-1489-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	593cee5f-98b3-4f51-bd9f-3bf3dbb6d1d1	2e4532d8-cebf-4bdf-95d0-5c02f94d186e	g.chr2:234835266G>A	uc002vvh.2	+	2	124	c.84G>A	c.(82-84)GCG>GCA	p.A28A	TRPM8_uc010fyj.2_5'UTR	NM_024080	NP_076985	Q7Z2W7	TRPM8_HUMAN	transient receptor potential cation channel,	28	Cytoplasmic (Potential).					integral to membrane				skin(4)	4		Breast(86;0.00205)|Renal(207;0.00694)|all_lung(227;0.0129)|Lung NSC(271;0.0408)|all_hematologic(139;0.0753)|Acute lymphoblastic leukemia(138;0.224)		Epithelial(121;1.19e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000139)|Lung(119;0.00758)|LUSC - Lung squamous cell carcinoma(224;0.0108)	Menthol(DB00825)	ACTCCAGCGCGTCTCGGAGCA	0.512			NA											28	63					0	0	0.004656	0	0
GART	2618	broad.mit.edu	37	21	34883584	34883584	+	Silent	SNP	A	A	G			TCGA-67-3773-01A-01D-1040-01	TCGA-67-3773-10A-01D-1489-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	593cee5f-98b3-4f51-bd9f-3bf3dbb6d1d1	2e4532d8-cebf-4bdf-95d0-5c02f94d186e	g.chr21:34883584A>G	uc002yrx.2	-	17	2424	c.2289T>C	c.(2287-2289)ATT>ATC	p.I763I	GART_uc002yrz.2_Silent_p.I763I|GART_uc010gmd.2_Silent_p.I425I|GART_uc002yry.2_Silent_p.I763I	NM_000819	NP_000810	P22102	PUR2_HUMAN	phosphoribosylglycinamide formyltransferase,	763	AIRS.				'de novo' IMP biosynthetic process|purine base biosynthetic process	cytosol	ATP binding|metal ion binding|methyltransferase activity|phosphoribosylamine-glycine ligase activity|phosphoribosylformylglycinamidine cyclo-ligase activity|phosphoribosylglycinamide formyltransferase activity|protein binding			ovary(1)	1					Pemetrexed(DB00642)	CCACACTGCCAATCACCCAGG	0.453			NA											137	336					0	0	0.01441	0	0
DSCAM	1826	broad.mit.edu	37	21	41496170	41496170	+	Silent	SNP	G	G	A			TCGA-67-3773-01A-01D-1040-01	TCGA-67-3773-10A-01D-1489-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	593cee5f-98b3-4f51-bd9f-3bf3dbb6d1d1	2e4532d8-cebf-4bdf-95d0-5c02f94d186e	g.chr21:41496170G>A	uc002yyq.1	-	20	4100	c.3648C>T	c.(3646-3648)AAC>AAT	p.N1216N	DSCAM_uc002yyr.1_RNA	NM_001389	NP_001380	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule isoform	1216	Fibronectin type-III 4.|Extracellular (Potential).				cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			ovary(6)|skin(4)|upper_aerodigestive_tract(1)	11		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				GGATGATGCCGTTCAGCTTGA	0.572	Melanoma(134;970 1778 1785 21664 32388)		NA											12	334					0	0	0.010729	0	0
POFUT2	23275	broad.mit.edu	37	21	46697007	46697007	+	Missense_Mutation	SNP	C	C	A			TCGA-67-3773-01A-01D-1040-01	TCGA-67-3773-10A-01D-1489-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	593cee5f-98b3-4f51-bd9f-3bf3dbb6d1d1	2e4532d8-cebf-4bdf-95d0-5c02f94d186e	g.chr21:46697007C>A	uc002zhc.2	-	6	781	c.756G>T	c.(754-756)GAG>GAT	p.E252D	POFUT2_uc002zha.2_RNA|POFUT2_uc002zhb.2_RNA|POFUT2_uc002zhd.2_Missense_Mutation_p.E252D	NM_133635	NP_598368	Q9Y2G5	OFUT2_HUMAN	protein O-fucosyltransferase 2 isoform C	252					fucose metabolic process	endoplasmic reticulum	peptide-O-fucosyltransferase activity				0				Colorectal(79;0.243)		TGCTCCTGAACTCGTCTCCCA	0.612			NA											80	204					2.60632e-51	4.27984e-51	0.01441	1	0
CCDC116	164592	broad.mit.edu	37	22	21991045	21991045	+	Nonsense_Mutation	SNP	C	C	T			TCGA-67-3773-01A-01D-1040-01	TCGA-67-3773-10A-01D-1489-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	593cee5f-98b3-4f51-bd9f-3bf3dbb6d1d1	2e4532d8-cebf-4bdf-95d0-5c02f94d186e	g.chr22:21991045C>T	uc002zve.2	+	5	1621	c.1528C>T	c.(1528-1530)CAG>TAG	p.Q510*		NM_152612	NP_689825	Q8IYX3	CC116_HUMAN	coiled-coil domain containing 116	510										ovary(1)|skin(1)	2	Colorectal(54;0.105)					AAGGGCCCGGCAGGCCTCCCG	0.642			NA											91	149					0	0	0.01441	0	0
NPTXR	23467	broad.mit.edu	37	22	39218644	39218644	+	Silent	SNP	G	G	A	rs145163836		TCGA-67-3773-01A-01D-1040-01	TCGA-67-3773-10A-01D-1489-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	593cee5f-98b3-4f51-bd9f-3bf3dbb6d1d1	2e4532d8-cebf-4bdf-95d0-5c02f94d186e	g.chr22:39218644G>A	uc003awk.2	-	5	1627	c.1473C>T	c.(1471-1473)TTC>TTT	p.F491F		NM_014293	NP_055108	O95502	NPTXR_HUMAN	neuronal pentraxin receptor	491	Pentaxin.|Extracellular (Potential).					integral to membrane	metal ion binding			central_nervous_system(2)|skin(1)	3	Melanoma(58;0.04)					TGCAGACATCGAAGGCAGCCT	0.622	Pancreas(139;2521 3281 36965)		NA											20	49					0	0	0.008871	0	0
PRR5	55615	broad.mit.edu	37	22	45075718	45075718	+	Silent	SNP	C	C	T			TCGA-67-3773-01A-01D-1040-01	TCGA-67-3773-10A-01D-1489-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	593cee5f-98b3-4f51-bd9f-3bf3dbb6d1d1	2e4532d8-cebf-4bdf-95d0-5c02f94d186e	g.chr22:45075718C>T	uc010gzt.1	+	2	925	c.39C>T	c.(37-39)GGC>GGT	p.G13G	PRR5_uc003bew.1_Intron|PRR5_uc003bex.1_Intron|PRR5_uc010gzu.1_Intron|PRR5_uc003bey.1_Intron|PRR5_uc003bez.1_Intron	NM_001017530	NP_001017530	P85299	PRR5_HUMAN	proline rich 5 (renal) isoform 3	Error:Variant_position_missing_in_P85299_after_alignment					cell cycle					skin(1)	1		all_neural(38;0.00409)|Ovarian(80;0.024)|Glioma(61;0.0647)		UCEC - Uterine corpus endometrioid carcinoma (28;0.168)		AAGCCTGGGGCTCGGGAAGCC	0.612			NA											10	14					0	0	0.013537	0	0
MAGI1	9223	broad.mit.edu	37	3	65479199	65479199	+	Missense_Mutation	SNP	C	C	A			TCGA-67-3773-01A-01D-1040-01	TCGA-67-3773-10A-01D-1489-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	593cee5f-98b3-4f51-bd9f-3bf3dbb6d1d1	2e4532d8-cebf-4bdf-95d0-5c02f94d186e	g.chr3:65479199C>A	uc003dmn.2	-	3	1064	c.538G>T	c.(538-540)GGC>TGC	p.G180C	MAGI1_uc003dmm.2_Missense_Mutation_p.G180C|MAGI1_uc003dmo.2_Missense_Mutation_p.G180C|MAGI1_uc003dmp.2_Missense_Mutation_p.G180C|MAGI1_uc010hny.2_Missense_Mutation_p.G64C|MAGI1_uc003dmr.2_Missense_Mutation_p.G180C	NM_001033057	NP_001028229	Q96QZ7	MAGI1_HUMAN	membrane associated guanylate kinase, WW and PDZ	180	Guanylate kinase-like.				cell adhesion|cell surface receptor linked signaling pathway|protein complex assembly	tight junction	ATP binding|protein C-terminus binding			lung(2)|skin(1)|breast(1)|kidney(1)|pancreas(1)	6		Lung NSC(201;0.0016)		BRCA - Breast invasive adenocarcinoma(55;0.00138)|KIRC - Kidney renal clear cell carcinoma(15;0.0988)|Kidney(15;0.133)		TCATAGGTGCCGACTTCCAGA	0.498			NA											36	75					9.65963e-10	1.24537e-09	0.015359	1	0
EPHA6	285220	broad.mit.edu	37	3	96963011	96963011	+	Missense_Mutation	SNP	G	G	T			TCGA-67-3773-01A-01D-1040-01	TCGA-67-3773-10A-01D-1489-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	593cee5f-98b3-4f51-bd9f-3bf3dbb6d1d1	2e4532d8-cebf-4bdf-95d0-5c02f94d186e	g.chr3:96963011G>T	uc010how.1	+	5	1529	c.1486G>T	c.(1486-1488)GTA>TTA	p.V496L	EPHA6_uc003drp.1_Missense_Mutation_p.V496L	NM_001080448	NP_001073917	Q9UF33	EPHA6_HUMAN	EPH receptor A6 isoform a	401	Fibronectin type-III 1.|Extracellular (Potential).					integral to plasma membrane	ATP binding|ephrin receptor activity			stomach(5)|lung(4)|central_nervous_system(3)|breast(1)|skin(1)|ovary(1)|kidney(1)	16						TTCCGTGATAGTACTTGACTT	0.443			NA											14	29					0.000151284	0.0001662	0.016723	1	0
NAALADL2	254827	broad.mit.edu	37	3	174951895	174951895	+	Silent	SNP	T	T	C			TCGA-67-3773-01A-01D-1040-01	TCGA-67-3773-10A-01D-1489-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	593cee5f-98b3-4f51-bd9f-3bf3dbb6d1d1	2e4532d8-cebf-4bdf-95d0-5c02f94d186e	g.chr3:174951895T>C	uc003fit.2	+	3	807	c.720T>C	c.(718-720)TTT>TTC	p.F240F	NAALADL2_uc003fiu.1_Silent_p.F233F|NAALADL2_uc010hwy.1_Silent_p.F62F	NM_207015	NP_996898	Q58DX5	NADL2_HUMAN	N-acetylated alpha-linked acidic dipeptidase 2	240	Extracellular (Potential).				proteolysis	integral to membrane	peptidase activity			pancreas(1)	1	Ovarian(172;0.0102)	all_cancers(1;0.0272)|all_epithelial(1;0.0553)	OV - Ovarian serous cystadenocarcinoma(80;9.26e-28)	Colorectal(1;1.66e-10)|COAD - Colon adenocarcinoma(1;2.1e-07)|STAD - Stomach adenocarcinoma(1;0.00261)|READ - Rectum adenocarcinoma(3;0.0284)		GTCAATGCTTTCATCCTAATG	0.488			NA											3	95					0	0	0.004672	0	0
PEX5L	51555	broad.mit.edu	37	3	179519752	179519752	+	Missense_Mutation	SNP	G	G	C			TCGA-67-3773-01A-01D-1040-01	TCGA-67-3773-10A-01D-1489-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	593cee5f-98b3-4f51-bd9f-3bf3dbb6d1d1	2e4532d8-cebf-4bdf-95d0-5c02f94d186e	g.chr3:179519752G>C	uc003fki.1	-	15	1875	c.1745C>G	c.(1744-1746)CCT>CGT	p.P582R	PEX5L_uc011bqd.1_Missense_Mutation_p.P539R|PEX5L_uc011bqe.1_Missense_Mutation_p.P390R|PEX5L_uc011bqf.1_Missense_Mutation_p.P474R|PEX5L_uc003fkj.1_Missense_Mutation_p.P547R|PEX5L_uc010hxd.1_Missense_Mutation_p.P580R|PEX5L_uc011bqg.1_Missense_Mutation_p.P558R|PEX5L_uc011bqh.1_Missense_Mutation_p.P523R	NM_016559	NP_057643	Q8IYB4	PEX5R_HUMAN	peroxisomal biogenesis factor 5-like	582					protein import into peroxisome matrix|regulation of cAMP-mediated signaling	cytosol|peroxisomal membrane	peroxisome matrix targeting signal-1 binding			ovary(3)|large_intestine(1)	4	all_cancers(143;3.94e-14)|Ovarian(172;0.0338)|Breast(254;0.183)		OV - Ovarian serous cystadenocarcinoma(80;1.75e-26)|GBM - Glioblastoma multiforme(14;0.000518)			TGCAGGATGAGGAACTTGCTG	0.463			NA											76	189					0	0	0.01441	0	0
KDR	3791	broad.mit.edu	37	4	55955043	55955043	+	Missense_Mutation	SNP	C	C	T			TCGA-67-3773-01A-01D-1040-01	TCGA-67-3773-10A-01D-1489-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	593cee5f-98b3-4f51-bd9f-3bf3dbb6d1d1	2e4532d8-cebf-4bdf-95d0-5c02f94d186e	g.chr4:55955043C>T	uc003has.2	-	26	3804	c.3502G>A	c.(3502-3504)GCT>ACT	p.A1168T	KDR_uc003hat.1_Missense_Mutation_p.A1168T	NM_002253	NP_002244	P35968	VGFR2_HUMAN	kinase insert domain receptor precursor	1168	Cytoplasmic (Potential).				angiogenesis|cell differentiation|interspecies interaction between organisms|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of focal adhesion assembly|positive regulation of positive chemotaxis|regulation of cell shape	integral to plasma membrane	ATP binding|growth factor binding|Hsp90 protein binding|integrin binding|receptor signaling protein tyrosine kinase activity|vascular endothelial growth factor receptor activity			lung(16)|soft_tissue(4)|central_nervous_system(4)|large_intestine(2)|stomach(2)|skin(2)|ovary(2)|kidney(1)	33	all_cancers(7;0.0255)|all_lung(4;0.00175)|Lung NSC(11;0.00384)|all_epithelial(27;0.034)|Glioma(25;0.08)|all_neural(26;0.101)		Epithelial(7;0.189)		Sorafenib(DB00398)|Sunitinib(DB01268)	ACCTGCTGAGCATTAGCTTGC	0.502			NA	Mis		NSCLC|angiosarcoma				Familial_Infantile_Hemangioma	TSP Lung(20;0.16)			11	29					0	0	0.010729	0	0
IQGAP2	10788	broad.mit.edu	37	5	75936794	75936794	+	Nonsense_Mutation	SNP	G	G	T			TCGA-67-3773-01A-01D-1040-01	TCGA-67-3773-10A-01D-1489-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	593cee5f-98b3-4f51-bd9f-3bf3dbb6d1d1	2e4532d8-cebf-4bdf-95d0-5c02f94d186e	g.chr5:75936794G>T	uc003kek.2	+	17	2182	c.1960G>T	c.(1960-1962)GAG>TAG	p.E654*	IQGAP2_uc010izv.2_Nonsense_Mutation_p.E207*|IQGAP2_uc011csv.1_Intron|IQGAP2_uc003kel.2_Intron	NM_006633	NP_006624	Q13576	IQGA2_HUMAN	IQ motif containing GTPase activating protein 2	654					small GTPase mediated signal transduction	actin cytoskeleton	actin binding|calmodulin binding|GTPase inhibitor activity|Ras GTPase activator activity			ovary(6)|central_nervous_system(1)	7		all_lung(232;0.000514)|Lung NSC(167;0.00135)|Prostate(461;0.00838)|Ovarian(174;0.0149)		all cancers(79;1.38e-36)		TTACATTCGTGAGAATATATG	0.408			NA											15	59					2.32078e-09	2.94343e-09	0.003163	1	0
VCAN	1462	broad.mit.edu	37	5	82815769	82815769	+	Silent	SNP	T	T	C			TCGA-67-3773-01A-01D-1040-01	TCGA-67-3773-10A-01D-1489-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	593cee5f-98b3-4f51-bd9f-3bf3dbb6d1d1	2e4532d8-cebf-4bdf-95d0-5c02f94d186e	g.chr5:82815769T>C	uc003kii.3	+	7	2000	c.1644T>C	c.(1642-1644)TAT>TAC	p.Y548Y	VCAN_uc003kij.3_Intron|VCAN_uc010jau.2_Silent_p.Y548Y|VCAN_uc003kik.3_Intron	NM_004385	NP_004376	P13611	CSPG2_HUMAN	versican isoform 1 precursor	548	GAG-alpha (glucosaminoglycan attachment domain).				cell adhesion|cell recognition|glial cell migration	extracellular space|proteinaceous extracellular matrix	calcium ion binding|hyaluronic acid binding|sugar binding			ovary(7)|skin(6)|lung(2)|central_nervous_system(1)	16		Lung NSC(167;0.0216)|all_lung(232;0.0251)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;2.47e-41)|Epithelial(54;2.51e-34)|all cancers(79;5.19e-29)		CAGGTCACTATGGATTCACCT	0.408			NA											36	76					0	0	0.017118	0	0
TTC37	9652	broad.mit.edu	37	5	94818288	94818288	+	Silent	SNP	T	T	C			TCGA-67-3773-01A-01D-1040-01	TCGA-67-3773-10A-01D-1489-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	593cee5f-98b3-4f51-bd9f-3bf3dbb6d1d1	2e4532d8-cebf-4bdf-95d0-5c02f94d186e	g.chr5:94818288T>C	uc003klb.2	-	39	4371	c.4101A>G	c.(4099-4101)AGA>AGG	p.R1367R		NM_014639	NP_055454	Q6PGP7	TTC37_HUMAN	tetratricopeptide repeat domain 37	1367							binding			ovary(3)|pancreas(1)	4						ACTGAACTTGTCTCAAAAGTA	0.388			NA											21	20					0	0	0.012319	0	0
ELL2	22936	broad.mit.edu	37	5	95224622	95224622	+	Missense_Mutation	SNP	T	T	C			TCGA-67-3773-01A-01D-1040-01	TCGA-67-3773-10A-01D-1489-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	593cee5f-98b3-4f51-bd9f-3bf3dbb6d1d1	2e4532d8-cebf-4bdf-95d0-5c02f94d186e	g.chr5:95224622T>C	uc003klr.3	-	12	2226	c.1876A>G	c.(1876-1878)AGG>GGG	p.R626G		NM_012081	NP_036213	O00472	ELL2_HUMAN	elongation factor, RNA polymerase II, 2	626					regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter	transcription elongation factor complex				central_nervous_system(1)	1		all_cancers(142;2.04e-06)|all_epithelial(76;3.1e-09)|all_lung(232;0.00309)|Lung NSC(167;0.00454)|Ovarian(225;0.0165)|Colorectal(57;0.0343)|Breast(839;0.198)		all cancers(79;2.16e-15)		CCTATTAGCCTTTTGATGTGA	0.343			NA											3	30					0	0	0.009096	0	0
SEMA6A	57556	broad.mit.edu	37	5	115782618	115782618	+	Missense_Mutation	SNP	G	G	T			TCGA-67-3773-01A-01D-1040-01	TCGA-67-3773-10A-01D-1489-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	593cee5f-98b3-4f51-bd9f-3bf3dbb6d1d1	2e4532d8-cebf-4bdf-95d0-5c02f94d186e	g.chr5:115782618G>T	uc010jck.2	-	19	3493	c.2784C>A	c.(2782-2784)AGC>AGA	p.S928R	SEMA6A_uc003krx.3_Missense_Mutation_p.S945R|SEMA6A_uc011cwe.1_Missense_Mutation_p.S307R|SEMA6A_uc003krv.3_Missense_Mutation_p.S355R|SEMA6A_uc003krw.3_Missense_Mutation_p.S405R|SEMA6A_uc010jcj.2_Missense_Mutation_p.S472R	NM_020796	NP_065847	Q9H2E6	SEM6A_HUMAN	sema domain, transmembrane domain (TM), and	928	Cytoplasmic (Potential).				apoptosis|axon guidance|cell surface receptor linked signaling pathway|cytoskeleton organization|organ morphogenesis	axon|integral to membrane|plasma membrane	receptor activity			ovary(2)	2		all_cancers(142;0.00316)|all_epithelial(76;5.71e-05)|Prostate(80;0.00845)|Ovarian(225;0.0796)|Lung NSC(810;0.171)|all_lung(232;0.203)		OV - Ovarian serous cystadenocarcinoma(64;1.59e-08)|Epithelial(69;2e-08)|all cancers(49;5.7e-08)|COAD - Colon adenocarcinoma(49;0.151)		TGGCCTGGTGGCTTCTCGTGA	0.557			NA											36	73					1.03484e-13	1.41609e-13	0.005524	1	0
SNCAIP	9627	broad.mit.edu	37	5	121759333	121759333	+	Missense_Mutation	SNP	C	C	A			TCGA-67-3773-01A-01D-1040-01	TCGA-67-3773-10A-01D-1489-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	593cee5f-98b3-4f51-bd9f-3bf3dbb6d1d1	2e4532d8-cebf-4bdf-95d0-5c02f94d186e	g.chr5:121759333C>A	uc003ksw.1	+	4	1107	c.901C>A	c.(901-903)CTA>ATA	p.L301I	SNCAIP_uc011cwl.1_Intron|SNCAIP_uc010jct.2_Missense_Mutation_p.L301I|SNCAIP_uc003ksx.1_Missense_Mutation_p.L348I|SNCAIP_uc003ksy.1_Intron|SNCAIP_uc003ksz.1_Intron|SNCAIP_uc010jcu.2_Intron|SNCAIP_uc011cwm.1_Intron|SNCAIP_uc003kta.1_Intron|SNCAIP_uc010jcv.1_RNA|SNCAIP_uc010jcw.1_Intron|SNCAIP_uc010jcx.1_Missense_Mutation_p.L301I	NM_005460	NP_005451	Q9Y6H5	SNCAP_HUMAN	synuclein alpha interacting protein	301					cell death|dopamine metabolic process|regulation of inclusion body assembly|regulation of neurotransmitter secretion	cytoplasm|neuronal cell body|nucleolus|presynaptic membrane	ubiquitin protein ligase binding			ovary(1)|pancreas(1)	2		all_cancers(142;0.00787)|Prostate(80;0.0327)	KIRC - Kidney renal clear cell carcinoma(527;0.206)	OV - Ovarian serous cystadenocarcinoma(64;0.000625)|Epithelial(69;0.00216)|all cancers(49;0.0232)		GGTCAGTGGCCTAAACCGGAC	0.483			NA											43	89					1.00953e-15	1.44483e-15	0.013114	1	0
PCDHA8	56140	broad.mit.edu	37	5	140221181	140221181	+	Missense_Mutation	SNP	G	G	A			TCGA-67-3773-01A-01D-1040-01	TCGA-67-3773-10A-01D-1489-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	593cee5f-98b3-4f51-bd9f-3bf3dbb6d1d1	2e4532d8-cebf-4bdf-95d0-5c02f94d186e	g.chr5:140221181G>A	uc003lhs.2	+	1	275	c.275G>A	c.(274-276)CGC>CAC	p.R92H	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhr.1_Missense_Mutation_p.R92H	NM_018911	NP_061734	Q9Y5H6	PCDA8_HUMAN	protocadherin alpha 8 isoform 1 precursor	92	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			upper_aerodigestive_tract(1)|ovary(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGGATCGACCGCGAGGAGCTG	0.602			NA											114	367					0	0	0.01441	0	0
PCDHA12	56137	broad.mit.edu	37	5	140256557	140256557	+	Silent	SNP	C	C	A			TCGA-67-3773-01A-01D-1040-01	TCGA-67-3773-10A-01D-1489-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	593cee5f-98b3-4f51-bd9f-3bf3dbb6d1d1	2e4532d8-cebf-4bdf-95d0-5c02f94d186e	g.chr5:140256557C>A	uc003lic.2	+	1	1627	c.1500C>A	c.(1498-1500)GGC>GGA	p.G500G	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc003lia.2_Intron|PCDHA12_uc011daf.1_Silent_p.G500G	NM_018903	NP_061726	Q9UN75	PCDAC_HUMAN	protocadherin alpha 12 isoform 1 precursor	500	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGCGGGTGGGCGAGCACGCAC	0.677	Pancreas(113;759 1672 13322 24104 50104)		NA											57	97					5.86059e-21	8.70716e-21	0.01441	1	0
RARS	5917	broad.mit.edu	37	5	167933091	167933091	+	Missense_Mutation	SNP	A	A	G			TCGA-67-3773-01A-01D-1040-01	TCGA-67-3773-10A-01D-1489-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	593cee5f-98b3-4f51-bd9f-3bf3dbb6d1d1	2e4532d8-cebf-4bdf-95d0-5c02f94d186e	g.chr5:167933091A>G	uc003lzx.2	+	10	1164	c.1123A>G	c.(1123-1125)ATA>GTA	p.I375V	RARS_uc011deo.1_Missense_Mutation_p.I169V	NM_002887	NP_002878	P54136	SYRC_HUMAN	arginyl-tRNA synthetase	375					arginyl-tRNA aminoacylation	cytosol|nucleus|soluble fraction	arginine-tRNA ligase activity|ATP binding|protein binding			ovary(2)|skin(1)	3	Renal(175;0.000159)|Lung NSC(126;0.0875)|all_lung(126;0.166)	Medulloblastoma(196;0.0208)|all_neural(177;0.0227)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0693)|Epithelial(171;0.131)|OV - Ovarian serous cystadenocarcinoma(192;0.156)		ACCATTAACCATAGTAAAATC	0.358			NA											44	114					0	0	0.013114	0	0
TMEM63B	55362	broad.mit.edu	37	6	44119729	44119729	+	Missense_Mutation	SNP	G	G	T			TCGA-67-3773-01A-01D-1040-01	TCGA-67-3773-10A-01D-1489-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	593cee5f-98b3-4f51-bd9f-3bf3dbb6d1d1	2e4532d8-cebf-4bdf-95d0-5c02f94d186e	g.chr6:44119729G>T	uc003owr.2	+	19	1884	c.1820G>T	c.(1819-1821)AGG>ATG	p.R607M	TMEM63B_uc003ows.2_Missense_Mutation_p.R510M|TMEM63B_uc010jyz.2_RNA	NM_018426	NP_060896	Q5T3F8	TM63B_HUMAN	transmembrane protein 63B	607						integral to membrane	nucleotide binding|protein binding			pancreas(2)|central_nervous_system(1)	3	all_cancers(18;1.66e-06)|Lung NSC(15;0.00108)|all_lung(25;0.00278)|Hepatocellular(11;0.00309)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0215)			GCCGCCGAGAGGCGCAACGTG	0.672			NA									OREG0017465	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	23	14					1.39806e-14	1.96483e-14	0.008361	1	0
PAQR8	85315	broad.mit.edu	37	6	52268034	52268034	+	Missense_Mutation	SNP	G	G	A			TCGA-67-3773-01A-01D-1040-01	TCGA-67-3773-10A-01D-1489-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	593cee5f-98b3-4f51-bd9f-3bf3dbb6d1d1	2e4532d8-cebf-4bdf-95d0-5c02f94d186e	g.chr6:52268034G>A	uc003pao.3	+	2	197	c.23G>A	c.(22-24)CGC>CAC	p.R8H		NM_133367	NP_588608	Q8TEZ7	MPRB_HUMAN	progestin and adipoQ receptor family member	8	Cytoplasmic (Potential).				cell differentiation|multicellular organismal development|oogenesis	integral to membrane|plasma membrane	receptor activity|steroid binding				0	Lung NSC(77;0.0875)					ATCTTGGAGCGCCTGAGCACC	0.622			NA											10	49					0	0	0.013537	0	0
COL12A1	1303	broad.mit.edu	37	6	75841736	75841736	+	Missense_Mutation	SNP	G	G	A			TCGA-67-3773-01A-01D-1040-01	TCGA-67-3773-10A-01D-1489-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	593cee5f-98b3-4f51-bd9f-3bf3dbb6d1d1	2e4532d8-cebf-4bdf-95d0-5c02f94d186e	g.chr6:75841736G>A	uc003phs.2	-	35	6023	c.5857C>T	c.(5857-5859)CGC>TGC	p.R1953C	COL12A1_uc003pht.2_Missense_Mutation_p.R789C	NM_004370	NP_004361	Q99715	COCA1_HUMAN	collagen, type XII, alpha 1 long isoform	1953	Fibronectin type-III 15.				cell adhesion|collagen fibril organization|skeletal system development	collagen type XII|extracellular space	extracellular matrix structural constituent conferring tensile strength			ovary(6)|large_intestine(1)|breast(1)|skin(1)	9						GGGTCCCAGCGAACATCGAGG	0.458			NA											14	56					0	0	0.020292	0	0
UBE2CBP	90025	broad.mit.edu	37	6	83775392	83775392	+	Nonsense_Mutation	SNP	C	C	A			TCGA-67-3773-01A-01D-1040-01	TCGA-67-3773-10A-01D-1489-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	593cee5f-98b3-4f51-bd9f-3bf3dbb6d1d1	2e4532d8-cebf-4bdf-95d0-5c02f94d186e	g.chr6:83775392C>A	uc003pjp.2	-	1	154	c.46G>T	c.(46-48)GGA>TGA	p.G16*	UBE2CBP_uc011dyx.1_RNA|UBE2CBP_uc003pjr.2_5'UTR|DOPEY1_uc003pjs.1_5'Flank	NM_198920	NP_944602	Q7Z6J8	UB2CB_HUMAN	ubiquitin-conjugating enzyme E2C binding	16						cytoplasm	ligase activity			ovary(1)	1		all_cancers(76;0.000374)|Acute lymphoblastic leukemia(125;3.85e-06)|all_hematologic(105;0.0017)|all_epithelial(107;0.0548)		BRCA - Breast invasive adenocarcinoma(397;0.0944)		TGCAGCTGTCCCCGCACCTCC	0.672			NA									OREG0017550	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	14	16					7.93312e-07	9.44707e-07	0.020292	1	0
HOXA11	3207	broad.mit.edu	37	7	27222458	27222459	+	Missense_Mutation	DNP	TT	TT	AG			TCGA-67-3773-01A-01D-1040-01	TCGA-67-3773-10A-01D-1489-08	TT	TT	-	-	TT	TT	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	593cee5f-98b3-4f51-bd9f-3bf3dbb6d1d1	2e4532d8-cebf-4bdf-95d0-5c02f94d186e	g.chr7:27222458_27222459TT>AG	uc003syx.2	-	2	970_971	c.898_899AA>CT	c.(898-900)AAC>CTC	p.N300L	HOXA10_uc003syw.3_5'Flank|HOXA11_uc003syy.2_RNA|HOXA11AS_uc003syz.1_5'Flank	NM_005523	NP_005514	P31270	HXA11_HUMAN	homeobox A11	300	Homeobox.				branching involved in ureteric bud morphogenesis|cartilage development involved in endochondral bone morphogenesis|developmental growth|dorsal/ventral pattern formation|mesodermal cell fate specification|positive regulation of cell development|positive regulation of chondrocyte differentiation	protein-DNA complex|transcription factor complex	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			lung(1)|breast(1)	2						ACGGTCTCTGTTAATTTTTTTT	0.446			NA	T	NUP98	CML								49	167					0	0	0.004672	0	0
FAM188B	84182	broad.mit.edu	37	7	30821598	30821598	+	Missense_Mutation	SNP	G	G	T			TCGA-67-3773-01A-01D-1040-01	TCGA-67-3773-10A-01D-1489-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	593cee5f-98b3-4f51-bd9f-3bf3dbb6d1d1	2e4532d8-cebf-4bdf-95d0-5c02f94d186e	g.chr7:30821598G>T	uc003tbt.2	+	3	266	c.189G>T	c.(187-189)AAG>AAT	p.K63N	FAM188B_uc010kwe.2_Missense_Mutation_p.K34N	NM_032222	NP_115598	Q4G0A6	F188B_HUMAN	hypothetical protein LOC84182	63											0						GATAGGCAAAGGAAAATCCTC	0.363			NA											20	46					2.37509e-13	3.22186e-13	0.010504	1	0
RELN	5649	broad.mit.edu	37	7	103162494	103162494	+	Missense_Mutation	SNP	G	G	A	rs139106600		TCGA-67-3773-01A-01D-1040-01	TCGA-67-3773-10A-01D-1489-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	593cee5f-98b3-4f51-bd9f-3bf3dbb6d1d1	2e4532d8-cebf-4bdf-95d0-5c02f94d186e	g.chr7:103162494G>A	uc003vca.2	-	48	7803	c.7643C>T	c.(7642-7644)TCG>TTG	p.S2548L	RELN_uc010liz.2_Missense_Mutation_p.S2548L	NM_005045	NP_005036	P78509	RELN_HUMAN	reelin isoform a	2548					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			ovary(8)|upper_aerodigestive_tract(5)|large_intestine(2)|central_nervous_system(2)|skin(1)|pancreas(1)	19				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		AGCCATTCCCGACGCCACGGC	0.488	NSCLC(146;835 1944 15585 22231 52158)		NA											56	129					0	0	0.01441	0	0
LRRN3	54674	broad.mit.edu	37	7	110764933	110764933	+	Missense_Mutation	SNP	G	G	T			TCGA-67-3773-01A-01D-1040-01	TCGA-67-3773-10A-01D-1489-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	593cee5f-98b3-4f51-bd9f-3bf3dbb6d1d1	2e4532d8-cebf-4bdf-95d0-5c02f94d186e	g.chr7:110764933G>T	uc003vft.3	+	4	3151	c.2105G>T	c.(2104-2106)GGT>GTT	p.G702V	IMMP2L_uc003vfq.1_Intron|IMMP2L_uc010ljr.1_Intron|IMMP2L_uc003vfr.2_Intron|LRRN3_uc003vfu.3_Missense_Mutation_p.G702V|LRRN3_uc003vfs.3_Missense_Mutation_p.G702V	NM_001099660	NP_001093130	Q9H3W5	LRRN3_HUMAN	leucine rich repeat neuronal 3 precursor	702	Cytoplasmic (Potential).					integral to membrane				skin(3)|ovary(2)|pancreas(2)|central_nervous_system(1)	8				UCEC - Uterine corpus endometrioid carcinoma (4;0.245)|LUSC - Lung squamous cell carcinoma(290;0.0715)|Lung(3;0.0864)|STAD - Stomach adenocarcinoma(3;0.125)		ACTGTTATAGGTTTACCAACA	0.343			NA											3	20					6.4e-05	7.23478e-05	0.004672	1	0
PLXNA4	91584	broad.mit.edu	37	7	132193285	132193285	+	Silent	SNP	C	C	A			TCGA-67-3773-01A-01D-1040-01	TCGA-67-3773-10A-01D-1489-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	593cee5f-98b3-4f51-bd9f-3bf3dbb6d1d1	2e4532d8-cebf-4bdf-95d0-5c02f94d186e	g.chr7:132193285C>A	uc003vra.3	-	2	397	c.168G>T	c.(166-168)GTG>GTT	p.V56V	PLXNA4_uc003vrc.2_Silent_p.V56V|PLXNA4_uc003vrb.2_Silent_p.V56V	NM_020911	NP_065962	Q9HCM2	PLXA4_HUMAN	plexin A4 isoform 1	56	Extracellular (Potential).|Sema.					integral to membrane|intracellular|plasma membrane				ovary(1)	1						TCCTCTCATCCACCACCAGGT	0.592			NA											39	91					1.59361e-14	2.21967e-14	0.006999	1	0
LRGUK	136332	broad.mit.edu	37	7	133812255	133812255	+	Silent	SNP	C	C	T			TCGA-67-3773-01A-01D-1040-01	TCGA-67-3773-10A-01D-1489-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	593cee5f-98b3-4f51-bd9f-3bf3dbb6d1d1	2e4532d8-cebf-4bdf-95d0-5c02f94d186e	g.chr7:133812255C>T	uc003vrm.1	+	1	151	c.135C>T	c.(133-135)CCC>CCT	p.P45P		NM_144648	NP_653249	Q96M69	LRGUK_HUMAN	leucine-rich repeats and guanylate kinase domain	45							ATP binding|kinase activity			lung(2)|skin(2)|kidney(1)	5						GGTCTTTTCCCATGGGGCAGA	0.577			NA											79	165					0	0	0.01441	0	0
HTR5A	3361	broad.mit.edu	37	7	154875952	154875952	+	Missense_Mutation	SNP	G	G	A			TCGA-67-3773-01A-01D-1040-01	TCGA-67-3773-10A-01D-1489-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	593cee5f-98b3-4f51-bd9f-3bf3dbb6d1d1	2e4532d8-cebf-4bdf-95d0-5c02f94d186e	g.chr7:154875952G>A	uc003wlu.1	+	2	893	c.829G>A	c.(829-831)GAG>AAG	p.E277K		NM_024012	NP_076917	P47898	5HT5A_HUMAN	5-hydroxytryptamine receptor 5A	277	Cytoplasmic (By similarity).					integral to plasma membrane	serotonin receptor activity			ovary(2)|large_intestine(1)	3	all_neural(206;0.119)	all_hematologic(28;0.0592)	OV - Ovarian serous cystadenocarcinoma(82;0.0238)	UCEC - Uterine corpus endometrioid carcinoma (81;0.171)		CACGTGGCGGGAGCAGAAGGA	0.607			NA											43	54					0	0	0.01441	0	0
CSMD1	64478	broad.mit.edu	37	8	2944626	2944626	+	Silent	SNP	G	G	T			TCGA-67-3773-01A-01D-1040-01	TCGA-67-3773-10A-01D-1489-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	593cee5f-98b3-4f51-bd9f-3bf3dbb6d1d1	2e4532d8-cebf-4bdf-95d0-5c02f94d186e	g.chr8:2944626G>T	uc011kwk.1	-	49	7860	c.7470C>A	c.(7468-7470)CTC>CTA	p.L2490L	CSMD1_uc011kwj.1_Silent_p.L1819L|CSMD1_uc010lrg.2_Silent_p.L558L	NM_033225	NP_150094	Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1 precursor	2490	Sushi 14.|Extracellular (Potential).					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		TACCCTGGCAGAGTGGCGTGA	0.453			NA											19	22					1.01871e-10	1.34677e-10	0.008871	1	0
RP1L1	94137	broad.mit.edu	37	8	10467287	10467287	+	Missense_Mutation	SNP	G	G	T			TCGA-67-3773-01A-01D-1040-01	TCGA-67-3773-10A-01D-1489-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	593cee5f-98b3-4f51-bd9f-3bf3dbb6d1d1	2e4532d8-cebf-4bdf-95d0-5c02f94d186e	g.chr8:10467287G>T	uc003wtc.2	-	4	4550	c.4321C>A	c.(4321-4323)CCG>ACG	p.P1441T		NM_178857	NP_849188	Q8IWN7	RP1L1_HUMAN	retinitis pigmentosa 1-like 1	1441					intracellular signal transduction					ovary(4)|breast(3)|central_nervous_system(1)	8				COAD - Colon adenocarcinoma(149;0.0811)		GCGGGGCACGGCTCTGCAGAG	0.627			NA											250	481					1.45934e-97	2.47454e-97	0.01441	1	0
XPO7	23039	broad.mit.edu	37	8	21853061	21853061	+	Missense_Mutation	SNP	G	G	T			TCGA-67-3773-01A-01D-1040-01	TCGA-67-3773-10A-01D-1489-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	593cee5f-98b3-4f51-bd9f-3bf3dbb6d1d1	2e4532d8-cebf-4bdf-95d0-5c02f94d186e	g.chr8:21853061G>T	uc003xaa.3	+	21	2398	c.2296G>T	c.(2296-2298)GCC>TCC	p.A766S	XPO7_uc010lti.2_Missense_Mutation_p.A775S|XPO7_uc010ltk.2_Missense_Mutation_p.A767S	NM_015024	NP_055839	Q9UIA9	XPO7_HUMAN	exportin 7 isoform b	766					mRNA transport|protein export from nucleus|transmembrane transport	cytoplasm|nuclear pore	nuclear export signal receptor activity|protein transporter activity			ovary(1)|kidney(1)|breast(1)|central_nervous_system(1)|pancreas(1)	5				Colorectal(74;0.0187)|COAD - Colon adenocarcinoma(73;0.0724)		CCATGATCCAGCCTGTACTAC	0.448			NA											13	28					0.000219431	0.00023938	0.020292	1	0
SNTG1	54212	broad.mit.edu	37	8	51617263	51617264	+	Missense_Mutation	DNP	GG	GG	TT			TCGA-67-3773-01A-01D-1040-01	TCGA-67-3773-10A-01D-1489-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	593cee5f-98b3-4f51-bd9f-3bf3dbb6d1d1	2e4532d8-cebf-4bdf-95d0-5c02f94d186e	g.chr8:51617263_51617264GG>TT	uc010lxy.1	+	17	1513_1514	c.1142_1143GG>TT	c.(1141-1143)TGG>TTT	p.W381F	SNTG1_uc003xqs.1_Missense_Mutation_p.W381F|SNTG1_uc010lxz.1_Missense_Mutation_p.W381F|SNTG1_uc011ldl.1_RNA	NM_018967	NP_061840	Q9NSN8	SNTG1_HUMAN	syntrophin, gamma 1	381	PH.				cell communication	cytoplasm|cytoskeleton|nucleus|ruffle membrane|syntrophin complex	actin binding|protein C-terminus binding			ovary(5)	5		all_cancers(86;0.00754)|all_epithelial(80;9.76e-05)|Lung NSC(129;0.000865)|all_lung(136;0.00249)|Colorectal(162;0.22)				CTCGCCCAGTGGGAAAGAGCCT	0.554			NA											17	55					0	0	0.004672	0	0
GEM	2669	broad.mit.edu	37	8	95272446	95272446	+	Missense_Mutation	SNP	C	C	A			TCGA-67-3773-01A-01D-1040-01	TCGA-67-3773-10A-01D-1489-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	593cee5f-98b3-4f51-bd9f-3bf3dbb6d1d1	2e4532d8-cebf-4bdf-95d0-5c02f94d186e	g.chr8:95272446C>A	uc003ygj.2	-	2	535	c.286G>T	c.(286-288)GCA>TCA	p.A96S	GEM_uc003ygi.2_Missense_Mutation_p.A96S	NM_005261	NP_005252	P55040	GEM_HUMAN	GTP-binding mitogen-induced T-cell protein	96					cell surface receptor linked signaling pathway|immune response|small GTPase mediated signal transduction	internal side of plasma membrane	calmodulin binding|GDP binding|GTP binding|GTPase activity|magnesium ion binding			lung(1)	1	Breast(36;4.65e-06)	Myeloproliferative disorder(644;0.204)	BRCA - Breast invasive adenocarcinoma(8;0.00691)			TGCACACCTGCAAAGATGTTG	0.592	GBM(125;80 1653 28655 32188 47338)|Esophageal Squamous(19;97 579 13602 49091 51766)		NA											67	147					8.20758e-20	1.19662e-19	0.01441	1	0
C8orf47	203111	broad.mit.edu	37	8	99102146	99102146	+	Missense_Mutation	SNP	C	C	T			TCGA-67-3773-01A-01D-1040-01	TCGA-67-3773-10A-01D-1489-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	593cee5f-98b3-4f51-bd9f-3bf3dbb6d1d1	2e4532d8-cebf-4bdf-95d0-5c02f94d186e	g.chr8:99102146C>T	uc003yih.1	+	2	1049	c.901C>T	c.(901-903)CCT>TCT	p.P301S		NM_173549	NP_775820	Q6P6B1	CH047_HUMAN	hypothetical protein LOC203111	301	Glu-rich.										0	Breast(36;2.31e-06)		OV - Ovarian serous cystadenocarcinoma(57;0.214)			GCAGATTCAACCTGAAGGAAT	0.438			NA											47	87					0	0	0.01441	0	0
ADCY8	114	broad.mit.edu	37	8	131792870	131792870	+	Silent	SNP	G	G	A			TCGA-67-3773-01A-01D-1040-01	TCGA-67-3773-10A-01D-1489-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	593cee5f-98b3-4f51-bd9f-3bf3dbb6d1d1	2e4532d8-cebf-4bdf-95d0-5c02f94d186e	g.chr8:131792870G>A	uc003ytd.3	-	18	3778	c.3522C>T	c.(3520-3522)GTC>GTT	p.V1174V	ADCY8_uc010mds.2_Silent_p.V1043V	NM_001115	NP_001106	P40145	ADCY8_HUMAN	adenylate cyclase 8	1174	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|membrane fraction|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|metal ion binding			skin(4)|large_intestine(1)|central_nervous_system(1)	6	Esophageal squamous(12;0.00693)|Ovarian(258;0.00707)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000538)			GGTTGGGTTGGACTCTTCCCA	0.522			NA								HNSCC(32;0.087)			59	125					0	0	0.01441	0	0
PDCD1LG2	80380	broad.mit.edu	37	9	5522564	5522564	+	Silent	SNP	A	A	C			TCGA-67-3773-01A-01D-1040-01	TCGA-67-3773-10A-01D-1489-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	593cee5f-98b3-4f51-bd9f-3bf3dbb6d1d1	2e4532d8-cebf-4bdf-95d0-5c02f94d186e	g.chr9:5522564A>C	uc003zjg.3	+	2	291	c.18A>C	c.(16-18)CTA>CTC	p.L6L	C9orf46_uc003zjd.2_Intron|PDCD1LG2_uc011lmc.1_Silent_p.L6L|PDCD1LG2_uc011lmd.1_Silent_p.L6L|PDCD1LG2_uc010mhp.1_Silent_p.L6L|PDCD1LG2_uc010mho.1_Silent_p.L6L	NM_025239	NP_079515	Q9BQ51	PD1L2_HUMAN	programmed cell death 1 ligand 2 precursor	6					immune response|T cell costimulation	endomembrane system|extracellular region|integral to membrane|plasma membrane	receptor activity				0	all_hematologic(13;0.158)	Acute lymphoblastic leukemia(23;0.154)		GBM - Glioblastoma multiforme(50;0.000767)|Lung(218;0.112)		TCCTCCTGCTAATGTTGAGCC	0.443			NA											8	176					0	0	0.00308	0	0
PTPRD	5789	broad.mit.edu	37	9	8528763	8528763	+	Missense_Mutation	SNP	C	C	A			TCGA-67-3773-01A-01D-1040-01	TCGA-67-3773-10A-01D-1489-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	593cee5f-98b3-4f51-bd9f-3bf3dbb6d1d1	2e4532d8-cebf-4bdf-95d0-5c02f94d186e	g.chr9:8528763C>A	uc003zkk.2	-	14	1080	c.369G>T	c.(367-369)AGG>AGT	p.R123S	PTPRD_uc003zkp.2_Missense_Mutation_p.R123S|PTPRD_uc003zkq.2_Missense_Mutation_p.R123S|PTPRD_uc003zkr.2_Missense_Mutation_p.R123S|PTPRD_uc003zks.2_Missense_Mutation_p.R123S|PTPRD_uc003zkl.2_Missense_Mutation_p.R123S|PTPRD_uc003zkm.2_Missense_Mutation_p.R123S|PTPRD_uc003zkn.2_Missense_Mutation_p.R123S|PTPRD_uc003zko.2_Missense_Mutation_p.R123S|PTPRD_uc003zkt.1_Missense_Mutation_p.R123S	NM_002839	NP_002830	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	123	Extracellular (Potential).				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			lung(14)|large_intestine(3)|ovary(2)|breast(2)|urinary_tract(1)	22		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		TAGGGAAGCCCCTGGGAATTT	0.468			NA								TSP Lung(15;0.13)			9	38					1.08611e-07	1.33412e-07	0.010729	1	0
NUP188	23511	broad.mit.edu	37	9	131765095	131765095	+	Splice_Site	SNP	G	G	C			TCGA-67-3773-01A-01D-1040-01	TCGA-67-3773-10A-01D-1489-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	593cee5f-98b3-4f51-bd9f-3bf3dbb6d1d1	2e4532d8-cebf-4bdf-95d0-5c02f94d186e	g.chr9:131765095G>C	uc004bws.1	+	37	4160	c.4138_splice	c.e37-1	p.T1380_splice	NUP188_uc004bwu.2_Splice_Site_p.T723_splice	NM_015354	NP_056169	Q5SRE5	NU188_HUMAN	nucleoporin 188kDa						carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear pore	protein binding			ovary(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)|kidney(1)|breast(1)	7						TTGTATCTTAGACACCTAGTG	0.557			NA											5	191					0	0	0.014758	0	0
IL13RA2	3598	broad.mit.edu	37	X	114242517	114242517	+	Missense_Mutation	SNP	C	C	A			TCGA-67-3773-01A-01D-1040-01	TCGA-67-3773-10A-01D-1489-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	593cee5f-98b3-4f51-bd9f-3bf3dbb6d1d1	2e4532d8-cebf-4bdf-95d0-5c02f94d186e	g.chrX:114242517C>A	uc004epx.2	-	8	1100	c.975G>T	c.(973-975)TGG>TGT	p.W325C	IL13RA2_uc010nqd.1_Missense_Mutation_p.W325C	NM_000640	NP_000631	Q14627	I13R2_HUMAN	interleukin 13 receptor, alpha 2 precursor	325	Extracellular (Potential).|WSXWS motif.|Fibronectin type-III 3.					extracellular space|integral to membrane|soluble fraction	cytokine receptor activity			upper_aerodigestive_tract(1)|ovary(1)|lung(1)	3						GTTTATCACTCCACTCACTCC	0.338			NA											16	16					9.16793e-09	1.13508e-08	0.00499	1	0
GLUD2	2747	broad.mit.edu	37	X	120182373	120182374	+	Missense_Mutation	DNP	GG	GG	TT			TCGA-67-3773-01A-01D-1040-01	TCGA-67-3773-10A-01D-1489-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	593cee5f-98b3-4f51-bd9f-3bf3dbb6d1d1	2e4532d8-cebf-4bdf-95d0-5c02f94d186e	g.chrX:120182373_120182374GG>TT	uc004eto.2	+	1	912_913	c.835_836GG>TT	c.(835-837)GGG>TTG	p.G279L		NM_012084	NP_036216	P49448	DHE4_HUMAN	glutamate dehydrogenase 2 precursor	279					glutamate biosynthetic process|glutamate catabolic process	mitochondrial matrix	ADP binding|glutamate dehydrogenase|glutamate dehydrogenase activity|GTP binding|leucine binding			pancreas(1)	1					L-Glutamic Acid(DB00142)|NADH(DB00157)	TGTCTTCCATGGGATTGAAAAC	0.436			NA											69	67					0	0	0.004672	0	0
Unknown	0	broad.mit.edu	37	X	155254706	155254706	+	Missense_Mutation	SNP	C	C	T			TCGA-67-3773-01A-01D-1040-01	TCGA-67-3773-10A-01D-1489-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	593cee5f-98b3-4f51-bd9f-3bf3dbb6d1d1	2e4532d8-cebf-4bdf-95d0-5c02f94d186e	g.chrX:155254706C>T	uc004fnx.3	+	8	1056	c.602C>T	c.(601-603)ACG>ATG	p.T201M		NM_182905	NP_878908			WAS protein family homolog 1												NA						GTGAGAGCCACGAGCCAAGGT	0.637			NA											4	8					0	0	0.014758	0	0
OR2M3	127062	broad.mit.edu	37	1	248367162	248367162	+	Frame_Shift_Del	DEL	G	G	-			TCGA-67-3773-01A-01D-1040-01	TCGA-67-3773-10A-01D-1489-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	593cee5f-98b3-4f51-bd9f-3bf3dbb6d1d1	2e4532d8-cebf-4bdf-95d0-5c02f94d186e	g.chr1:248367162delG	uc010pzg.1	+	1	793	c.793delG	c.(793-795)GATfs	p.D265fs		NM_001004689	NP_001004689	Q8NG83	OR2M3_HUMAN	olfactory receptor, family 2, subfamily M,	265	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			GCCCACATCTGATCGCTCCCC	0.502			NA											53	128	---	---	---	---	NA	NA	NA	NA	NA
GNS	2799	broad.mit.edu	37	12	65152963	65152968	+	In_Frame_Del	DEL	CCAGCA	CCAGCA	-			TCGA-67-3773-01A-01D-1040-01	TCGA-67-3773-10A-01D-1489-08	CCAGCA	CCAGCA	-	-	CCAGCA	CCAGCA	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	593cee5f-98b3-4f51-bd9f-3bf3dbb6d1d1	2e4532d8-cebf-4bdf-95d0-5c02f94d186e	g.chr12:65152963_65152968delCCAGCA	uc001ssg.3	-	1	259_264	c.89_94delTGCTGG	c.(88-96)GTGCTGGGC>GGC	p.VL30del	GNS_uc010ssq.1_In_Frame_Del_p.VL30del|GNS_uc010ssr.1_In_Frame_Del_p.VL30del	NM_002076	NP_002067	P15586	GNS_HUMAN	glucosamine (N-acetyl)-6-sulfatase precursor	30_31						lysosome	metal ion binding|N-acetylglucosamine-6-sulfatase activity|protein binding			central_nervous_system(1)	1	Lung NSC(1;7.25e-14)|all_lung(1;1.25e-12)		LUAD - Lung adenocarcinoma(6;0.115)	GBM - Glioblastoma multiforme(28;0.0435)		AGGCAGCCGCCCAGCACCAGCAGTAG	0.723			NA											3	4	---	---	---	---	NA	NA	NA	NA	NA
MAGEL2	54551	broad.mit.edu	37	15	23889920	23889920	+	Frame_Shift_Del	DEL	G	G	-			TCGA-67-3773-01A-01D-1040-01	TCGA-67-3773-10A-01D-1489-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	593cee5f-98b3-4f51-bd9f-3bf3dbb6d1d1	2e4532d8-cebf-4bdf-95d0-5c02f94d186e	g.chr15:23889920delG	uc001ywj.3	-	1	1256	c.1161delC	c.(1159-1161)CCCfs	p.P387fs		NM_019066	NP_061939			MAGE-like protein 2												0		all_cancers(20;1.78e-24)|all_epithelial(15;7.75e-22)|Lung NSC(15;2.96e-18)|all_lung(15;2.8e-17)|Breast(32;0.000625)|Colorectal(260;0.14)		all cancers(64;1.84e-06)|Epithelial(43;1.2e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00177)		ACACAACTACGGGCAGAGAGC	0.642			NA											21	77	---	---	---	---	NA	NA	NA	NA	NA
CHD2	1106	broad.mit.edu	37	15	93489385	93489389	+	Frame_Shift_Del	DEL	ATTGC	ATTGC	-			TCGA-67-3773-01A-01D-1040-01	TCGA-67-3773-10A-01D-1489-08	ATTGC	ATTGC	-	-	ATTGC	ATTGC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	593cee5f-98b3-4f51-bd9f-3bf3dbb6d1d1	2e4532d8-cebf-4bdf-95d0-5c02f94d186e	g.chr15:93489385_93489389delATTGC	uc002bsp.2	+	12	1891_1895	c.1316_1320delATTGC	c.(1315-1320)AATTGCfs	p.N439fs	CHD2_uc002bsn.2_Frame_Shift_Del_p.N439fs|CHD2_uc002bso.1_Frame_Shift_Del_p.N439fs|CHD2_uc010urb.1_Frame_Shift_Del_p.N452fs|CHD2_uc010bof.1_RNA	NM_001271	NP_001262	O14647	CHD2_HUMAN	chromodomain helicase DNA binding protein 2	439_440	Chromo 2.				regulation of transcription from RNA polymerase II promoter	nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding			ovary(1)|skin(1)	2	Lung NSC(78;0.00976)|all_lung(78;0.016)		BRCA - Breast invasive adenocarcinoma(143;0.0282)|OV - Ovarian serous cystadenocarcinoma(32;0.0814)			AAATTCCAGAATTGCATTGACAGCT	0.429			NA											34	111	---	---	---	---	NA	NA	NA	NA	NA
OR11H1	81061	broad.mit.edu	37	22	16449040	16449040	+	Frame_Shift_Del	DEL	G	G	-			TCGA-67-3773-01A-01D-1040-01	TCGA-67-3773-10A-01D-1489-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	593cee5f-98b3-4f51-bd9f-3bf3dbb6d1d1	2e4532d8-cebf-4bdf-95d0-5c02f94d186e	g.chr22:16449040delG	uc011agd.1	-	1	765	c.765delC	c.(763-765)ACCfs	p.T255fs		NM_001005239	NP_001005239	Q8NG94	O11H1_HUMAN	olfactory receptor, family 11, subfamily H,	255	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_hematologic(4;0.00567)|Acute lymphoblastic leukemia(84;0.0977)	all_epithelial(15;0.208)		Kidney(3;0.00216)|KIRC - Kidney renal clear cell carcinoma(3;0.00244)|Lung(27;0.0724)|COAD - Colon adenocarcinoma(3;0.211)		GAGACCCACAGGTAGAGAAGG	0.443			NA											32	62	---	---	---	---	NA	NA	NA	NA	NA