Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	ACHILLES_Top_Genes	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
MIB2	142678	broad.mit.edu	37	1	1565853	1565853	+	Silent	SNP	C	C	G			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr1:1565853C>G	uc001agg.2	+	20	3112	c.2985C>G	c.(2983-2985)CTC>CTG	p.L995L	MIB2_uc001agh.2_Silent_p.L981L|MIB2_uc001agi.2_Silent_p.L991L|MIB2_uc001agj.2_Silent_p.L836L|MIB2_uc001agk.2_Silent_p.L930L|MIB2_uc001agm.2_3'UTR|MIB2_uc010nyq.1_Silent_p.L951L|MIB2_uc009vkh.2_Silent_p.L801L|MIB2_uc001agn.2_Silent_p.L627L|MIB2_uc001ago.2_Silent_p.L78L|MMP23B_uc001agp.2_5'Flank|MMP23B_uc001agq.2_5'Flank|MMP23B_uc001agr.2_5'Flank|MMP23B_uc009vki.2_5'Flank	NM_080875	NP_543151	Q96AX9	MIB2_HUMAN	mindbomb homolog 2	995	RING-type 2.				Notch signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade	endosome	actin binding|signal transducer activity|ubiquitin-protein ligase activity|zinc ion binding				0	all_cancers(77;0.000708)|all_epithelial(69;0.000943)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;6.04e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;5.26e-37)|OV - Ovarian serous cystadenocarcinoma(86;2.54e-23)|GBM - Glioblastoma multiforme(42;9e-08)|Colorectal(212;0.000155)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00227)|STAD - Stomach adenocarcinoma(132;0.00644)|BRCA - Breast invasive adenocarcinoma(365;0.00786)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.199)		GCTCCGCGCTCAGCGCCTGCC	0.716			NA											6	12					0	0	0.001168	0	0
CDK11B	984	broad.mit.edu	37	1	1647827	1647827	+	Missense_Mutation	SNP	T	T	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr1:1647827T>A	uc001agv.1	-	9	563	c.452A>T	c.(451-453)CAG>CTG	p.Q151L	CDK11B_uc001ags.1_5'UTR|CDK11B_uc001agt.1_5'UTR|CDK11B_uc001aha.1_Missense_Mutation_p.Q117L|CDK11B_uc001agw.1_Missense_Mutation_p.Q106L|CDK11B_uc001agy.1_Missense_Mutation_p.Q140L|CDK11B_uc001agx.1_Missense_Mutation_p.Q140L|CDK11B_uc001agz.1_5'UTR|SLC35E2B_uc001ahh.3_Intron|SLC35E2_uc009vkm.1_Intron|CDK11A_uc009vkr.2_Missense_Mutation_p.Q139L|CDK11A_uc009vks.2_Missense_Mutation_p.Q149L|CDK11A_uc010nys.1_Missense_Mutation_p.Q139L|CDK11A_uc010nyt.1_Missense_Mutation_p.Q149L|CDK11A_uc010nyu.1_RNA|CDK11A_uc009vkt.1_Missense_Mutation_p.Q139L|CDK11A_uc009vku.1_Missense_Mutation_p.Q139L|CDK11A_uc009vkv.1_Missense_Mutation_p.Q149L|CDK11A_uc001aht.1_Missense_Mutation_p.Q139L|CDK11B_uc001ahu.1_Missense_Mutation_p.Q139L|CDK11B_uc001ahv.1_Missense_Mutation_p.Q149L|CDK11B_uc001ahw.1_Missense_Mutation_p.Q149L	NM_033486	NP_277021	P21127	CD11B_HUMAN	cell division cycle 2-like 1 (PITSLRE proteins)	151	Glu-rich.				apoptosis|cell proliferation|mitosis|regulation of cell growth|regulation of mRNA processing|regulation of transcription, DNA-dependent	cytoplasm|nucleus	ATP binding|cyclin-dependent protein kinase activity|protein binding			skin(1)	1						CCTTCTCTTCTGTCTTTCCCA	0.502			NA											8	73					0	0	0.014323	0	0
PANK4	55229	broad.mit.edu	37	1	2451331	2451331	+	Silent	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr1:2451331C>T	uc001ajm.1	-	6	771	c.762G>A	c.(760-762)GTG>GTA	p.V254V	PANK4_uc010nza.1_Silent_p.V215V	NM_018216	NP_060686	Q9NVE7	PANK4_HUMAN	pantothenate kinase 4	254					coenzyme A biosynthetic process	cytoplasm	ATP binding|pantothenate kinase activity			upper_aerodigestive_tract(1)|large_intestine(1)|ovary(1)	3	all_cancers(77;0.000158)|all_epithelial(69;8.01e-05)|all_lung(157;0.0212)|Lung NSC(156;0.0376)|Ovarian(185;0.0634)	all_epithelial(116;3.18e-20)|all_lung(118;1.67e-08)|Lung NSC(185;2.69e-06)|Breast(487;0.00147)|Renal(390;0.00183)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.0847)|Medulloblastoma(700;0.123)		Epithelial(90;1.54e-37)|OV - Ovarian serous cystadenocarcinoma(86;6.95e-23)|GBM - Glioblastoma multiforme(42;2.81e-08)|Colorectal(212;4.25e-05)|COAD - Colon adenocarcinoma(227;0.000196)|Kidney(185;0.000342)|BRCA - Breast invasive adenocarcinoma(365;0.00445)|KIRC - Kidney renal clear cell carcinoma(229;0.00549)|STAD - Stomach adenocarcinoma(132;0.00644)|Lung(427;0.201)		AGACGTCCCGCACCAGCATGT	0.682			NA											6	5					0	0	0.001168	0	0
MMEL1	79258	broad.mit.edu	37	1	2535350	2535350	+	Silent	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr1:2535350C>T	uc001ajy.2	-	11	1228	c.1014G>A	c.(1012-1014)GAG>GAA	p.E338E	MMEL1_uc009vlg.1_RNA	NM_033467	NP_258428	Q495T6	MMEL1_HUMAN	membrane metallo-endopeptidase-like 1	338	Lumenal (Potential).				proteolysis	extracellular region|integral to membrane|intracellular membrane-bounded organelle	metal ion binding|metalloendopeptidase activity				0	all_cancers(77;0.000233)|all_epithelial(69;8.55e-05)|all_lung(157;0.0228)|Lung NSC(156;0.0402)|Ovarian(185;0.0634)	all_epithelial(116;1.03e-20)|all_lung(118;5.15e-09)|Lung NSC(185;9.02e-07)|Breast(487;0.00147)|Renal(390;0.00183)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.0847)|Medulloblastoma(700;0.123)		Epithelial(90;4.31e-38)|OV - Ovarian serous cystadenocarcinoma(86;8.52e-23)|GBM - Glioblastoma multiforme(42;1.49e-08)|Colorectal(212;4.79e-05)|COAD - Colon adenocarcinoma(227;0.000213)|Kidney(185;0.000371)|BRCA - Breast invasive adenocarcinoma(365;0.00219)|KIRC - Kidney renal clear cell carcinoma(229;0.00571)|STAD - Stomach adenocarcinoma(132;0.00645)|Lung(427;0.131)		TTTGCAGCTCCTCCAGTCCCA	0.662			NA											21	87					0	0	0.003954	0	0
PRDM16	63976	broad.mit.edu	37	1	3328985	3328985	+	Missense_Mutation	SNP	G	G	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr1:3328985G>T	uc001akf.2	+	9	2304	c.2224G>T	c.(2224-2226)GAC>TAC	p.D742Y	PRDM16_uc001akc.2_Missense_Mutation_p.D742Y|PRDM16_uc001akd.2_Missense_Mutation_p.D742Y|PRDM16_uc001ake.2_Missense_Mutation_p.D742Y|PRDM16_uc009vlh.2_Missense_Mutation_p.D443Y	NM_022114	NP_071397	Q9HAZ2	PRD16_HUMAN	PR domain containing 16 isoform 1	742	Mediates interaction with SKI and regulation of TGF-beta signaling.|Interaction with CTBP1 and CTBP2 (By similarity).				brown fat cell differentiation|negative regulation of granulocyte differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transforming growth factor beta receptor signaling pathway|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|regulation of cellular respiration|transcription, DNA-dependent	transcriptional repressor complex	protein binding|sequence-specific DNA binding|transcription coactivator activity|zinc ion binding			lung(3)|ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	7	all_cancers(77;0.00208)|all_epithelial(69;0.000732)|Ovarian(185;0.0634)|Lung NSC(156;0.109)|all_lung(157;0.111)	all_epithelial(116;2.03e-21)|all_lung(118;7.55e-09)|Lung NSC(185;1.28e-06)|Breast(487;0.000792)|Renal(390;0.00137)|Hepatocellular(190;0.00515)|Myeloproliferative disorder(586;0.0267)|Ovarian(437;0.0365)|Lung SC(97;0.114)|Medulloblastoma(700;0.134)		Epithelial(90;5.59e-35)|OV - Ovarian serous cystadenocarcinoma(86;1.99e-20)|GBM - Glioblastoma multiforme(42;3.72e-11)|Colorectal(212;0.000425)|BRCA - Breast invasive adenocarcinoma(365;0.000946)|COAD - Colon adenocarcinoma(227;0.000968)|Kidney(185;0.00155)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0175)|Lung(427;0.137)		CCCCTTCACGGACCGAGCCCT	0.647			NA	T	EVI1	MDS|AML								42	42					4.42602e-33	6.19729e-33	0.00874	1	0
TP73	7161	broad.mit.edu	37	1	3649416	3649416	+	Missense_Mutation	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr1:3649416C>T	uc001akp.2	+	14	1794	c.1684C>T	c.(1684-1686)CGC>TGC	p.R562C	TP73_uc001akq.2_Intron|TP73_uc001akr.2_Missense_Mutation_p.R513C|TP73_uc009vlk.1_3'UTR|TP73_uc001aks.2_3'UTR|TP73_uc010nzk.1_Missense_Mutation_p.R491C|TP73_uc010nzl.1_Missense_Mutation_p.R111C	NM_005427	NP_005418	O15350	P73_HUMAN	tumor protein p73 isoform a	562					cellular response to UV|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|mismatch repair|mitotic cell cycle G1/S transition DNA damage checkpoint|negative regulation of JUN kinase activity|negative regulation of neuron apoptosis|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|protein tetramerization|response to gamma radiation|response to X-ray	chromatin|cytosol|transcription factor complex	chromatin binding|damaged DNA binding|double-stranded DNA binding|metal ion binding|p53 binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription regulatory region DNA binding|transcription repressor activity			ovary(1)|lung(1)	2	all_cancers(77;0.0395)|Ovarian(185;0.0634)|Lung NSC(156;0.188)|all_lung(157;0.198)	all_epithelial(116;7.42e-17)|all_lung(118;1.86e-06)|Lung NSC(185;0.000163)|Renal(390;0.00357)|Breast(487;0.00446)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Lung SC(97;0.109)|Ovarian(437;0.127)		Epithelial(90;5.57e-38)|OV - Ovarian serous cystadenocarcinoma(86;1.87e-22)|GBM - Glioblastoma multiforme(42;5.72e-16)|Colorectal(212;2.22e-05)|COAD - Colon adenocarcinoma(227;8.48e-05)|Kidney(185;0.000539)|BRCA - Breast invasive adenocarcinoma(365;0.000868)|STAD - Stomach adenocarcinoma(132;0.0072)|KIRC - Kidney renal clear cell carcinoma(229;0.00751)|Lung(427;0.226)		GCAGCTGCTCCGCTCTAGCAA	0.682			NA											20	13					0	0	0.010504	0	0
ACOT7	11332	broad.mit.edu	37	1	6453348	6453348	+	Missense_Mutation	SNP	C	C	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr1:6453348C>A	uc001amt.2	-	1	479	c.112G>T	c.(112-114)GTC>TTC	p.V38F	ACOT7_uc010nzq.1_5'UTR|ACOT7_uc001amu.2_RNA|ACOT7_uc001amv.2_RNA	NM_007274	NP_009205	O00154	BACH_HUMAN	acyl-CoA thioesterase 7 isoform hBACHa	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment						mitochondrion|nucleus	carboxylesterase activity|fatty-acyl-CoA binding|palmitoyl-CoA hydrolase activity				0	Ovarian(185;0.0634)|all_lung(157;0.175)	all_cancers(23;1.42e-38)|all_epithelial(116;3.96e-23)|all_lung(118;3.69e-08)|Lung NSC(185;8.52e-07)|all_hematologic(16;6.92e-06)|Colorectal(325;4.53e-05)|Acute lymphoblastic leukemia(12;5e-05)|all_neural(13;0.000164)|Breast(487;0.000688)|Renal(390;0.0007)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0393)|Medulloblastoma(700;0.211)		Epithelial(90;9.16e-37)|GBM - Glioblastoma multiforme(13;5.89e-29)|OV - Ovarian serous cystadenocarcinoma(86;7.63e-19)|Colorectal(212;1.27e-07)|COAD - Colon adenocarcinoma(227;2.06e-05)|Kidney(185;7.74e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.00129)|BRCA - Breast invasive adenocarcinoma(365;0.00132)|STAD - Stomach adenocarcinoma(132;0.00195)|READ - Rectum adenocarcinoma(331;0.0481)		GGCGTCTCGACGTCTGGGCCC	0.756	GBM(74;673 1226 4974 11850 13190)		NA											16	5					1.02788e-11	1.29444e-11	0.00499	1	0
TNFRSF25	8718	broad.mit.edu	37	1	6521752	6521752	+	Silent	SNP	G	G	C			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr1:6521752G>C	uc001ane.2	-	10	1084	c.996C>G	c.(994-996)GGC>GGG	p.G332G	TNFRSF25_uc001ana.2_Silent_p.G149G|TNFRSF25_uc001anb.2_RNA|TNFRSF25_uc001anc.2_RNA|TNFRSF25_uc001and.2_Silent_p.G105G|TNFRSF25_uc009vlz.2_RNA|TNFRSF25_uc001anf.2_Silent_p.G295G|TNFRSF25_uc001ang.2_Silent_p.G287G|TNFRSF25_uc001anh.2_Silent_p.G341G	NM_003790	NP_003781	Q93038	TNR25_HUMAN	tumor necrosis factor receptor superfamily,	332	Death.|Cytoplasmic (Potential).				apoptosis|induction of apoptosis by extracellular signals	cytosol|extracellular region|integral to plasma membrane	tumor necrosis factor receptor activity			central_nervous_system(2)|breast(1)	3	Ovarian(185;0.0386)|all_lung(157;0.154)	all_cancers(23;1.7e-35)|all_epithelial(116;2.78e-22)|all_lung(118;7.57e-07)|Lung NSC(185;4.26e-06)|Colorectal(325;4.47e-05)|all_hematologic(16;0.00014)|Breast(487;0.000688)|Renal(390;0.0007)|Acute lymphoblastic leukemia(12;0.00157)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0448)		Epithelial(90;4.58e-35)|GBM - Glioblastoma multiforme(13;3.06e-27)|Colorectal(212;6.01e-08)|COAD - Colon adenocarcinoma(227;1.3e-05)|Kidney(185;4.88e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000871)|BRCA - Breast invasive adenocarcinoma(365;0.00105)|STAD - Stomach adenocarcinoma(132;0.00158)|READ - Rectum adenocarcinoma(331;0.0419)		AGAGCTGCGGGCCCGGCTGCA	0.711			NA											9	3					0	0	0.006214	0	0
CAMTA1	23261	broad.mit.edu	37	1	7805972	7805972	+	Missense_Mutation	SNP	A	A	G			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr1:7805972A>G	uc001aoi.2	+	18	4645	c.4438A>G	c.(4438-4440)AGT>GGT	p.S1480G	CAMTA1_uc001aok.3_Missense_Mutation_p.S523G|CAMTA1_uc001aoj.2_Missense_Mutation_p.S436G|CAMTA1_uc009vmf.2_Missense_Mutation_p.S70G	NM_015215	NP_056030	Q9Y6Y1	CMTA1_HUMAN	calmodulin-binding transcription activator 1	1480					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	calmodulin binding			ovary(5)|central_nervous_system(2)|breast(1)|pancreas(1)	9	Ovarian(185;0.0634)	all_epithelial(116;8.38e-23)|all_lung(118;5.87e-07)|Lung NSC(185;3.43e-06)|Renal(390;0.000219)|Breast(487;0.000307)|Colorectal(325;0.000615)|Hepatocellular(190;0.0088)|Myeloproliferative disorder(586;0.0303)|Ovarian(437;0.0388)		UCEC - Uterine corpus endometrioid carcinoma (279;0.101)|Colorectal(212;1.33e-05)|COAD - Colon adenocarcinoma(227;0.000235)|BRCA - Breast invasive adenocarcinoma(304;0.000864)|Kidney(185;0.00244)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0179)|READ - Rectum adenocarcinoma(331;0.133)		CTCTCCCGTCAGTGAAATCGC	0.478			NA											30	103					0	0	0.010818	0	0
RERE	473	broad.mit.edu	37	1	8425882	8425882	+	Silent	SNP	G	G	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr1:8425882G>A	uc001ape.2	-	14	2247	c.1437C>T	c.(1435-1437)TCC>TCT	p.S479S	RERE_uc001apf.2_Silent_p.S479S|RERE_uc010nzx.1_Silent_p.S211S|RERE_uc001apd.2_5'UTR	NM_012102	NP_036234	Q9P2R6	RERE_HUMAN	atrophin-1 like protein isoform a	479					multicellular organismal development|NLS-bearing substrate import into nucleus	mitochondrion	poly-glutamine tract binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2	Ovarian(185;0.0661)	all_epithelial(116;1.17e-21)|all_lung(118;1.4e-06)|Lung NSC(185;3.06e-06)|Renal(390;0.000147)|Breast(348;0.000206)|Colorectal(325;0.00187)|Hepatocellular(190;0.00825)|Ovarian(437;0.0253)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;9.64e-67)|GBM - Glioblastoma multiforme(8;9.89e-33)|Colorectal(212;1.45e-07)|COAD - Colon adenocarcinoma(227;3.42e-05)|Kidney(185;6e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000533)|KIRC - Kidney renal clear cell carcinoma(229;0.00106)|STAD - Stomach adenocarcinoma(132;0.00118)|READ - Rectum adenocarcinoma(331;0.0419)|Lung(427;0.195)		AGAATTCACTGGACGGGGGTC	0.637			NA											30	39					0	0	0.010818	0	0
SPSB1	80176	broad.mit.edu	37	1	9416304	9416304	+	Silent	SNP	G	G	C			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr1:9416304G>C	uc010oae.1	+	2	693	c.354G>C	c.(352-354)GCG>GCC	p.A118A	SPSB1_uc001apv.2_Silent_p.A118A	NM_025106	NP_079382	Q96BD6	SPSB1_HUMAN	splA/ryanodine receptor domain and SOCS box	118	B30.2/SPRY.				intracellular signal transduction	cytoplasm					0	all_lung(157;0.194)	all_epithelial(116;4.38e-15)|all_lung(118;0.000156)|Lung NSC(185;0.000446)|Renal(390;0.000469)|Colorectal(325;0.0062)|Breast(348;0.0139)|Hepatocellular(190;0.0228)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.104)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;2.72e-07)|COAD - Colon adenocarcinoma(227;9.12e-05)|Kidney(185;0.000296)|KIRC - Kidney renal clear cell carcinoma(229;0.00106)|STAD - Stomach adenocarcinoma(132;0.00193)|BRCA - Breast invasive adenocarcinoma(304;0.00202)|READ - Rectum adenocarcinoma(331;0.0419)		TGGGGGTGGCGACGGCAGACG	0.662			NA											72	50					0	0	0.01441	0	0
MASP2	10747	broad.mit.edu	37	1	11087442	11087442	+	Missense_Mutation	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr1:11087442C>T	uc001aru.2	-	11	1582	c.1561G>A	c.(1561-1563)GAA>AAA	p.E521K		NM_006610	NP_006601	O00187	MASP2_HUMAN	mannan-binding lectin serine protease 2 isoform	521	Peptidase S1.				complement activation, classical pathway|complement activation, lectin pathway|proteolysis	extracellular region	calcium ion binding|calcium-dependent protein binding|serine-type endopeptidase activity			ovary(2)|pancreas(1)|skin(1)	4	Ovarian(185;0.249)	Lung NSC(185;1.04e-05)|all_lung(284;1.31e-05)|Renal(390;0.000147)|Colorectal(325;0.00205)|Breast(348;0.00262)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)	STAD - Stomach adenocarcinoma(5;0.071)	UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.12e-07)|COAD - Colon adenocarcinoma(227;7.07e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|Kidney(185;0.000722)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|READ - Rectum adenocarcinoma(331;0.0487)|STAD - Stomach adenocarcinoma(313;0.192)		GTATAACCTTCATGTATAAAA	0.403	GBM(35;611 746 20780 22741 36496)		NA											76	70					0	0	0.01441	0	0
MTOR	2475	broad.mit.edu	37	1	11297963	11297963	+	Silent	SNP	C	C	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr1:11297963C>A	uc001asd.2	-	13	2266	c.2145G>T	c.(2143-2145)GTG>GTT	p.V715V		NM_004958	NP_004949	P42345	MTOR_HUMAN	FK506 binding protein 12-rapamycin associated	715					cell growth|cellular response to hypoxia|insulin receptor signaling pathway|nerve growth factor receptor signaling pathway|peptidyl-serine phosphorylation|phosphatidylinositol-mediated signaling|protein autophosphorylation|protein catabolic process|response to amino acid stimulus|response to nutrient|T cell costimulation|TOR signaling cascade	endoplasmic reticulum membrane|Golgi membrane|lysosome|mitochondrial outer membrane|phosphatidylinositol 3-kinase complex|PML body|TORC1 complex|TORC2 complex	ATP binding|phosphoprotein binding|protein serine/threonine kinase activity			central_nervous_system(7)|lung(6)|ovary(6)|skin(3)|kidney(3)|large_intestine(2)|breast(2)	29						TGAGTCGGCCCACAGTGCAGA	0.577			NA											27	33					1.66031e-10	2.04129e-10	0.003954	1	0
VPS13D	55187	broad.mit.edu	37	1	12374318	12374318	+	Missense_Mutation	SNP	G	G	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr1:12374318G>A	uc001atv.2	+	30	7223	c.7082G>A	c.(7081-7083)TGT>TAT	p.C2361Y	VPS13D_uc001atw.2_Missense_Mutation_p.C2361Y|VPS13D_uc001atx.2_Missense_Mutation_p.C1549Y|VPS13D_uc001aty.1_Missense_Mutation_p.C99Y	NM_015378	NP_056193	Q5THJ4	VP13D_HUMAN	vacuolar protein sorting 13D isoform 1	2361				C -> R (in Ref. 6; CAE46021).	protein localization					ovary(4)|pancreas(1)	5	Ovarian(185;0.249)	Lung NSC(185;4.08e-05)|all_lung(284;4.55e-05)|Renal(390;0.000147)|Colorectal(325;0.00058)|Breast(348;0.00093)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0327)|Colorectal(212;4.63e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000289)|COAD - Colon adenocarcinoma(227;0.000801)|Kidney(185;0.00216)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(313;0.012)|READ - Rectum adenocarcinoma(331;0.0476)|Lung(427;0.209)		GTGTTCAGCTGTATCTTTCAG	0.493			NA											12	17					0	0	0.003163	0	0
PRAMEF11	440560	broad.mit.edu	37	1	12885059	12885059	+	Missense_Mutation	SNP	C	C	G	rs143004725	by1000genomes	TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr1:12885059C>G	uc001auk.2	-	4	1248	c.1052G>C	c.(1051-1053)TGC>TCC	p.C351S		NM_001146344	NP_001139816	O60813	PRA11_HUMAN	PRAME family member 11	351	LRR 6.										0						GGTGGCCATGCAGATGGGATT	0.532			NA											4	165					0	0	0.001168	0	0
PADI2	11240	broad.mit.edu	37	1	17431488	17431488	+	Missense_Mutation	SNP	C	C	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr1:17431488C>A	uc001baf.2	-	2	243	c.161G>T	c.(160-162)CGT>CTT	p.R54L	PADI2_uc010ocm.1_Missense_Mutation_p.R54L|PADI2_uc001bag.1_Missense_Mutation_p.R54L	NM_007365	NP_031391	Q9Y2J8	PADI2_HUMAN	peptidyl arginine deiminase, type II	54					peptidyl-citrulline biosynthetic process from peptidyl-arginine	cytoplasm	calcium ion binding|protein-arginine deiminase activity			ovary(3)|pancreas(1)|central_nervous_system(1)|skin(1)	6		Colorectal(325;3.46e-05)|Breast(348;0.000162)|Lung NSC(340;0.000422)|Renal(390;0.000518)|all_lung(284;0.000546)|Ovarian(437;0.00671)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00583)|BRCA - Breast invasive adenocarcinoma(304;1.49e-05)|COAD - Colon adenocarcinoma(227;1.54e-05)|Kidney(64;0.000258)|KIRC - Kidney renal clear cell carcinoma(64;0.00348)|STAD - Stomach adenocarcinoma(196;0.0072)|READ - Rectum adenocarcinoma(331;0.0698)|Lung(427;0.201)	L-Citrulline(DB00155)	CTCCCCATCACGCACCACCTC	0.662			NA											39	21					1.04594e-18	1.40231e-18	0.00623	1	0
UBR4	23352	broad.mit.edu	37	1	19491400	19491400	+	Silent	SNP	G	G	C			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr1:19491400G>C	uc001bbi.2	-	32	4408	c.4404C>G	c.(4402-4404)CTC>CTG	p.L1468L	UBR4_uc001bbm.1_Silent_p.L679L	NM_020765	NP_065816	Q5T4S7	UBR4_HUMAN	retinoblastoma-associated factor 600	1468					interspecies interaction between organisms	cytoplasm|cytoskeleton|integral to membrane|nucleus	calmodulin binding|ubiquitin-protein ligase activity|zinc ion binding			kidney(10)|ovary(7)|breast(4)|pancreas(2)|skin(2)	25		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000328)|Lung NSC(340;0.000406)|Breast(348;0.000814)|Ovarian(437;0.00774)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00674)|BRCA - Breast invasive adenocarcinoma(304;5.43e-05)|Kidney(64;0.000337)|KIRC - Kidney renal clear cell carcinoma(64;0.00426)|STAD - Stomach adenocarcinoma(196;0.00715)|READ - Rectum adenocarcinoma(331;0.0816)		TCATGCGGGTGAGCCAGGCCT	0.567			NA											41	80					0	0	0.00623	0	0
FAM43B	163933	broad.mit.edu	37	1	20879649	20879649	+	Silent	SNP	G	G	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr1:20879649G>A	uc001bdj.2	+	1	718	c.183G>A	c.(181-183)CAG>CAA	p.Q61Q		NM_207334	NP_997217	Q6ZT52	FA43B_HUMAN	family with sequence similarity 43, member B	61											0		Colorectal(325;0.000147)|Renal(390;0.000469)|Lung NSC(340;0.00412)|all_lung(284;0.00419)|Breast(348;0.00979)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0427)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|COAD - Colon adenocarcinoma(152;1.11e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000132)|Kidney(64;0.00016)|GBM - Glioblastoma multiforme(114;0.000399)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.195)		GCCGGCGCCAGAAAGTGGAGC	0.692			NA											8	15					0	0	0.00308	0	0
KIF17	57576	broad.mit.edu	37	1	21036154	21036154	+	Silent	SNP	G	G	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr1:21036154G>A	uc001bdr.3	-	4	766	c.648C>T	c.(646-648)ATC>ATT	p.I216I	KIF17_uc001bds.3_Silent_p.I216I	NM_020816	NP_065867	Q9P2E2	KIF17_HUMAN	kinesin family member 17 isoform a	216	Kinesin-motor.				microtubule-based movement|protein transport	cytoplasm|microtubule	ATP binding			ovary(3)|skin(1)	4		all_lung(284;2.99e-05)|Lung NSC(340;3.26e-05)|Colorectal(325;3.46e-05)|Renal(390;9.67e-05)|Breast(348;0.00179)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0185)|COAD - Colon adenocarcinoma(152;1.43e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000168)|Kidney(64;0.000221)|GBM - Glioblastoma multiforme(114;0.000651)|KIRC - Kidney renal clear cell carcinoma(64;0.0031)|STAD - Stomach adenocarcinoma(196;0.00336)|READ - Rectum adenocarcinoma(331;0.0686)|Lung(427;0.209)		TCTCGATGCTGATGGTGAAGA	0.597			NA											16	72					0	0	0.003163	0	0
HSPG2	3339	broad.mit.edu	37	1	22180713	22180713	+	Missense_Mutation	SNP	T	T	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr1:22180713T>A	uc001bfj.2	-	50	6452	c.6412A>T	c.(6412-6414)ACC>TCC	p.T2138S	HSPG2_uc009vqd.2_Missense_Mutation_p.T2139S	NM_005529	NP_005520	P98160	PGBM_HUMAN	heparan sulfate proteoglycan 2 precursor	2138	Ig-like C2-type 6.				angiogenesis|cell adhesion|lipid metabolic process|lipoprotein metabolic process	basement membrane|extracellular space|plasma membrane	protein C-terminus binding			ovary(5)|large_intestine(2)|central_nervous_system(1)|skin(1)	9		Colorectal(325;3.46e-05)|all_lung(284;7.93e-05)|Lung NSC(340;8.71e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0498)|OV - Ovarian serous cystadenocarcinoma(117;1.14e-26)|Colorectal(126;4.18e-07)|COAD - Colon adenocarcinoma(152;1.82e-05)|GBM - Glioblastoma multiforme(114;3.13e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000756)|STAD - Stomach adenocarcinoma(196;0.00656)|KIRC - Kidney renal clear cell carcinoma(1967;0.00942)|READ - Rectum adenocarcinoma(331;0.0721)|Lung(427;0.223)	Becaplermin(DB00102)|Palifermin(DB00039)	CCAGAATGGGTGCCGTGGAGC	0.617			NA											3	6					0	0	0.004672	0	0
HSPG2	3339	broad.mit.edu	37	1	22211041	22211041	+	Missense_Mutation	SNP	T	T	C			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr1:22211041T>C	uc001bfj.2	-	13	1674	c.1634A>G	c.(1633-1635)GAC>GGC	p.D545G	HSPG2_uc009vqd.2_Missense_Mutation_p.D546G	NM_005529	NP_005520	P98160	PGBM_HUMAN	heparan sulfate proteoglycan 2 precursor	545	Laminin IV type A 1.				angiogenesis|cell adhesion|lipid metabolic process|lipoprotein metabolic process	basement membrane|extracellular space|plasma membrane	protein C-terminus binding			ovary(5)|large_intestine(2)|central_nervous_system(1)|skin(1)	9		Colorectal(325;3.46e-05)|all_lung(284;7.93e-05)|Lung NSC(340;8.71e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0498)|OV - Ovarian serous cystadenocarcinoma(117;1.14e-26)|Colorectal(126;4.18e-07)|COAD - Colon adenocarcinoma(152;1.82e-05)|GBM - Glioblastoma multiforme(114;3.13e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000756)|STAD - Stomach adenocarcinoma(196;0.00656)|KIRC - Kidney renal clear cell carcinoma(1967;0.00942)|READ - Rectum adenocarcinoma(331;0.0721)|Lung(427;0.223)	Becaplermin(DB00102)|Palifermin(DB00039)	ATCGGGTTGGTCAAAGCGCAG	0.662			NA											38	151					0	0	0.00874	0	0
MYOM3	127294	broad.mit.edu	37	1	24401952	24401952	+	Silent	SNP	G	G	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr1:24401952G>A	uc001bin.3	-	22	2878	c.2715C>T	c.(2713-2715)ATC>ATT	p.I905I	MYOM3_uc001bim.3_Silent_p.I562I|MYOM3_uc001bio.2_Silent_p.I905I	NM_152372	NP_689585	Q5VTT5	MYOM3_HUMAN	myomesin family, member 3	905										skin(2)|ovary(1)	3		Colorectal(325;3.55e-05)|Renal(390;0.000703)|Lung NSC(340;0.001)|all_lung(284;0.0014)|Ovarian(437;0.00351)|Breast(348;0.0126)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;5.31e-24)|Colorectal(126;7.52e-08)|COAD - Colon adenocarcinoma(152;4.01e-06)|GBM - Glioblastoma multiforme(114;4.36e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00108)|KIRC - Kidney renal clear cell carcinoma(1967;0.00404)|STAD - Stomach adenocarcinoma(196;0.00966)|READ - Rectum adenocarcinoma(331;0.0678)|Lung(427;0.153)		CACCAACCTCGATCTCATGGG	0.348			NA											8	36					0	0	0.004482	0	0
GPR3	2827	broad.mit.edu	37	1	27720714	27720714	+	Silent	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr1:27720714C>T	uc001bod.2	+	2	507	c.412C>T	c.(412-414)CTG>TTG	p.L138L		NM_005281	NP_005272	P46089	GPR3_HUMAN	G protein-coupled receptor 3	138	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway	integral to plasma membrane				ovary(1)	1		Breast(348;1.53e-05)|Ovarian(437;0.0606)|all_lung(284;0.157)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0415)|OV - Ovarian serous cystadenocarcinoma(117;2.81e-26)|Colorectal(126;1.24e-08)|KIRC - Kidney renal clear cell carcinoma(1967;3.23e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|BRCA - Breast invasive adenocarcinoma(304;4.45e-06)|Lung(427;0.00163)|STAD - Stomach adenocarcinoma(196;0.00303)|LUSC - Lung squamous cell carcinoma(448;0.008)|READ - Rectum adenocarcinoma(331;0.0419)		CTACCTTTCTCTGTACAATGC	0.592			NA											64	79					0	0	0.01441	0	0
PTPRU	10076	broad.mit.edu	37	1	29609316	29609316	+	Missense_Mutation	SNP	G	G	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr1:29609316G>T	uc001bru.2	+	12	2107	c.1997G>T	c.(1996-1998)GGG>GTG	p.G666V	PTPRU_uc001brv.2_Missense_Mutation_p.G666V|PTPRU_uc001brw.2_Missense_Mutation_p.G666V|PTPRU_uc009vtq.2_Missense_Mutation_p.G666V|PTPRU_uc009vtr.2_Missense_Mutation_p.G666V	NM_005704	NP_005695	Q92729	PTPRU_HUMAN	protein tyrosine phosphatase, receptor type, U	666	Extracellular (Potential).|Fibronectin type-III 4.				canonical Wnt receptor signaling pathway|cell differentiation|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of transcription, DNA-dependent|protein localization at cell surface|transmembrane receptor protein tyrosine phosphatase signaling pathway	cell-cell junction|integral to plasma membrane	beta-catenin binding|transmembrane receptor protein tyrosine phosphatase activity			large_intestine(3)|ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	7		Colorectal(325;0.000399)|Lung NSC(340;0.00953)|all_lung(284;0.0112)|Breast(348;0.0126)|all_neural(195;0.0199)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0563)|Medulloblastoma(700;0.123)		Colorectal(126;6.99e-07)|COAD - Colon adenocarcinoma(152;3.18e-05)|STAD - Stomach adenocarcinoma(196;0.0234)|READ - Rectum adenocarcinoma(331;0.0686)|BRCA - Breast invasive adenocarcinoma(304;0.0871)		CACTACTTCGGGGCCGAACTG	0.667			NA											48	67					1.19451e-25	1.64557e-25	0.01441	1	0
PUM1	9698	broad.mit.edu	37	1	31425212	31425212	+	Splice_Site	SNP	T	T	G			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr1:31425212T>G	uc001bsi.1	-	16	2705	c.2592_splice	c.e16-1	p.R864_splice	PUM1_uc001bsf.1_Splice_Site_p.R530_splice|PUM1_uc001bsg.1_Splice_Site_p.R598_splice|PUM1_uc001bsh.1_Splice_Site_p.R864_splice|PUM1_uc001bsj.1_Splice_Site_p.R838_splice|PUM1_uc010oga.1_Splice_Site_p.R720_splice|PUM1_uc001bsk.1_Splice_Site_p.R900_splice|PUM1_uc010ogb.1_Splice_Site_p.R805_splice	NM_014676	NP_055491	Q14671	PUM1_HUMAN	pumilio 1 isoform 2						cellular membrane organization|post-Golgi vesicle-mediated transport|regulation of translation	cytosol	RNA binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3		Colorectal(325;0.0211)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0308)|all_neural(195;0.0381)|Breast(348;0.0848)|Medulloblastoma(700;0.123)		STAD - Stomach adenocarcinoma(196;0.0232)|READ - Rectum adenocarcinoma(331;0.0681)		TGAATGAATCTGAAGTACAAA	0.473			NA											21	42					0	0	0.010504	0	0
KHDRBS1	10657	broad.mit.edu	37	1	32503611	32503611	+	Missense_Mutation	SNP	C	C	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr1:32503611C>A	uc001bub.2	+	6	1187	c.1081C>A	c.(1081-1083)CCT>ACT	p.P361T	KHDRBS1_uc001bua.1_Missense_Mutation_p.P322T|KHDRBS1_uc001buc.1_RNA	NM_006559	NP_006550	Q07666	KHDR1_HUMAN	KH domain containing, RNA binding, signal	361	Pro-rich.				cell cycle arrest|cell proliferation|cell surface receptor linked signaling pathway|G2/M transition of mitotic cell cycle|mRNA processing|negative regulation of transcription, DNA-dependent|regulation of RNA export from nucleus|transcription, DNA-dependent	membrane|nucleus	DNA binding|RNA binding|SH3 domain binding|SH3/SH2 adaptor activity			ovary(1)	1		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.186)				GCCTCCACCTCCTGCACCAGA	0.527	Ovarian(173;401 1982 12359 31110 42403)		NA											16	104					3.41278e-10	4.18174e-10	0.00499	1	0
LCK	3932	broad.mit.edu	37	1	32739958	32739958	+	Missense_Mutation	SNP	G	G	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr1:32739958G>A	uc001bux.2	+	2	166	c.28G>A	c.(28-30)GAA>AAA	p.E10K	LCK_uc001buy.2_Missense_Mutation_p.E10K|LCK_uc001buz.2_Missense_Mutation_p.E10K|LCK_uc010ohc.1_Missense_Mutation_p.E54K|LCK_uc001bva.2_Missense_Mutation_p.E10K	NM_005356	NP_005347	P06239	LCK_HUMAN	lymphocyte-specific protein tyrosine kinase	10	Interactions with CD4 and CD8 (By similarity).				activation of caspase activity|cellular zinc ion homeostasis|induction of apoptosis|interspecies interaction between organisms|leukocyte migration|platelet activation|positive regulation of T cell receptor signaling pathway|regulation of defense response to virus by virus|release of sequestered calcium ion into cytosol|response to drug|T cell costimulation|T cell differentiation|T cell receptor signaling pathway|viral reproduction	cytosol|Golgi apparatus|membrane raft|pericentriolar material|plasma membrane	ATP binding|ATPase binding|CD4 receptor binding|CD8 receptor binding|glycoprotein binding|non-membrane spanning protein tyrosine kinase activity|phosphatidylinositol 3-kinase binding|protein C-terminus binding|protein kinase binding|protein serine/threonine phosphatase activity|SH2 domain binding			lung(3)|central_nervous_system(2)|ovary(1)	6		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Ovarian(437;0.101)|Breast(348;0.212)			Dasatinib(DB01254)	CTCACACCCGGAAGATGACTG	0.562			NA	T	TRB@	T-ALL								8	71					0	0	0.004482	0	0
S100PBP	64766	broad.mit.edu	37	1	33292344	33292344	+	Nonsense_Mutation	SNP	C	C	G			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr1:33292344C>G	uc001bvz.2	+	3	921	c.644C>G	c.(643-645)TCA>TGA	p.S215*	S100PBP_uc001bwa.1_Nonsense_Mutation_p.S215*|S100PBP_uc001bwb.1_Nonsense_Mutation_p.S215*|S100PBP_uc001bwc.2_Nonsense_Mutation_p.S215*|S100PBP_uc001bwd.2_RNA	NM_022753	NP_073590	Q96BU1	S1PBP_HUMAN	S100P binding protein isoform a	215						nucleus	calcium-dependent protein binding				0		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Breast(348;0.244)				CTCTCTTCTTCAAACAATAAC	0.443			NA											12	33					0	0	0.001855	0	0
CSMD2	114784	broad.mit.edu	37	1	34033349	34033349	+	Missense_Mutation	SNP	G	G	C			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr1:34033349G>C	uc001bxn.1	-	54	8184	c.8155C>G	c.(8155-8157)CCT>GCT	p.P2719A	CSMD2_uc001bxm.1_Missense_Mutation_p.P2742A	NM_052896	NP_443128	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	2719	Sushi 18.|Extracellular (Potential).					integral to membrane|plasma membrane	protein binding			ovary(6)|skin(5)|pancreas(1)	12		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				ATGGGCTCAGGAGTCCCACAG	0.537			NA											4	19					0	0	0.009096	0	0
EPHA10	284656	broad.mit.edu	37	1	38188721	38188721	+	Missense_Mutation	SNP	A	A	G			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr1:38188721A>G	uc009vvi.2	-	10	2038	c.1952T>C	c.(1951-1953)CTT>CCT	p.L651P	EPHA10_uc001cbt.2_5'Flank|EPHA10_uc009vvh.1_RNA|EPHA10_uc001cbu.2_RNA|EPHA10_uc001cbv.1_RNA	NM_001099439	NP_001092909	Q5JZY3	EPHAA_HUMAN	EPH receptor A10 isofom 3	651	Cytoplasmic (Potential).|Protein kinase.					extracellular region|integral to membrane|integral to plasma membrane	ATP binding|ephrin receptor activity|protein binding|transmembrane-ephrin receptor activity			breast(4)|stomach(3)|lung(1)	8	Acute lymphoblastic leukemia(166;0.074)|all_hematologic(146;0.197)	Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				GCCTCCTCCAAGGCTCCTCTC	0.617			NA											27	56					0	0	0.007291	0	0
NASP	4678	broad.mit.edu	37	1	46056896	46056896	+	Missense_Mutation	SNP	A	A	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr1:46056896A>T	uc001coi.1	+	2	163	c.61A>T	c.(61-63)ATT>TTT	p.I21F	NASP_uc010olq.1_Missense_Mutation_p.I21F|NASP_uc001coh.1_5'UTR|NASP_uc001coj.1_Missense_Mutation_p.I21F|NASP_uc010olr.1_Missense_Mutation_p.I21F	NM_002482	NP_002473	P49321	NASP_HUMAN	nuclear autoantigenic sperm protein isoform 2	21					blastocyst development|cell cycle|cell proliferation|DNA replication|histone exchange|protein transport	cytoplasm|nucleus	Hsp90 protein binding			ovary(1)	1	Acute lymphoblastic leukemia(166;0.155)|Lung SC(450;0.211)					TTATTACAGAATTGAAGATGT	0.299			NA											3	44					0	0	0.004672	0	0
CYP4X1	260293	broad.mit.edu	37	1	47505153	47505153	+	Missense_Mutation	SNP	G	G	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr1:47505153G>A	uc001cqt.2	+	8	1272	c.1022G>A	c.(1021-1023)AGA>AAA	p.R341K	CYP4X1_uc001cqr.2_Missense_Mutation_p.R340K|CYP4X1_uc001cqs.2_Missense_Mutation_p.R276K	NM_178033	NP_828847	Q8N118	CP4X1_HUMAN	cytochrome P450, family 4, subfamily X,	341						endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding			ovary(1)|skin(1)	2						CATCAAGAGAGATGCCGGGAG	0.522			NA											17	29					0	0	0.008871	0	0
FOXE3	2301	broad.mit.edu	37	1	47882444	47882444	+	Missense_Mutation	SNP	G	G	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr1:47882444G>T	uc001crk.2	+	1	701	c.457G>T	c.(457-459)GAC>TAC	p.D153Y		NM_012186	NP_036318	Q13461	FOXE3_HUMAN	forkhead box E3	153	Fork-head.				cell migration|embryonic organ morphogenesis|enteric nervous system development|hair follicle morphogenesis|hard palate development|lens morphogenesis in camera-type eye|pattern specification process|positive regulation of epithelial cell proliferation|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity|soft palate development|thyroid gland development|thyroid hormone generation	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding				0				READ - Rectum adenocarcinoma(2;0.0908)		CGCGGCCGCAGACATGTTCGA	0.557			NA											7	53					8.12818e-05	8.78788e-05	0.001984	1	0
USP1	7398	broad.mit.edu	37	1	62910485	62910485	+	Missense_Mutation	SNP	C	C	G			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr1:62910485C>G	uc001daj.1	+	6	962	c.634C>G	c.(634-636)CAA>GAA	p.Q212E	USP1_uc001dak.1_Missense_Mutation_p.Q212E|USP1_uc001dal.1_Missense_Mutation_p.Q212E	NM_001017415	NP_001017415	O94782	UBP1_HUMAN	ubiquitin specific protease 1	212					DNA repair|monoubiquitinated protein deubiquitination|regulation of DNA repair|response to UV|ubiquitin-dependent protein catabolic process	nucleoplasm	cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(1)	1		all_neural(321;0.0281)		BRCA - Breast invasive adenocarcinoma(111;8.01e-05)|KIRC - Kidney renal clear cell carcinoma(1967;0.00245)|OV - Ovarian serous cystadenocarcinoma(397;0.0535)		GGGAAACATTCAAGAAACATG	0.338	Ovarian(122;1846 2315 3982 19504)		NA											5	30					0	0	0.000602	0	0
JAK1	3716	broad.mit.edu	37	1	65321352	65321352	+	Missense_Mutation	SNP	C	C	G			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr1:65321352C>G	uc001dbu.1	-	11	1737	c.1488G>C	c.(1486-1488)AAG>AAC	p.K496N	JAK1_uc009wam.1_Missense_Mutation_p.K484N	NM_002227	NP_002218	P23458	JAK1_HUMAN	janus kinase 1	496	SH2.				interferon-gamma-mediated signaling pathway|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|response to antibiotic|type I interferon-mediated signaling pathway	cytoskeleton|cytosol|endomembrane system|membrane|nucleus	ATP binding|growth hormone receptor binding|non-membrane spanning protein tyrosine kinase activity			haematopoietic_and_lymphoid_tissue(34)|prostate(7)|soft_tissue(6)|lung(4)|breast(3)|central_nervous_system(2)|liver(2)|large_intestine(1)|stomach(1)|ovary(1)	61				BRCA - Breast invasive adenocarcinoma(111;0.0485)		TCTGAAAGTTCTTGAACTGCT	0.468			NA	Mis		ALL								4	20					0	0	0.000602	0	0
DNAJC6	9829	broad.mit.edu	37	1	65849892	65849892	+	Missense_Mutation	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr1:65849892C>T	uc001dcd.1	+	6	676	c.512C>T	c.(511-513)TCA>TTA	p.S171L	DNAJC6_uc001dcc.1_Missense_Mutation_p.S202L|DNAJC6_uc010opc.1_Missense_Mutation_p.S158L|DNAJC6_uc001dce.1_Missense_Mutation_p.S228L	NM_014787	NP_055602	O75061	AUXI_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 6	171	Phosphatase tensin-type.				cellular membrane organization|post-Golgi vesicle-mediated transport	cytosol	heat shock protein binding|protein tyrosine phosphatase activity|SH3 domain binding			large_intestine(1)|lung(1)|ovary(1)	3						CGGGCGGCATCATCAATTCTG	0.403			NA											15	54					0	0	0.00245	0	0
ACADM	34	broad.mit.edu	37	1	76216217	76216217	+	Nonsense_Mutation	SNP	A	A	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr1:76216217A>T	uc001dgw.3	+	10	1361	c.931A>T	c.(931-933)AAG>TAG	p.K311*	ACADM_uc010ord.1_Nonsense_Mutation_p.K225*|ACADM_uc009wbp.2_Nonsense_Mutation_p.K315*|ACADM_uc009wbr.2_Nonsense_Mutation_p.K344*|ACADM_uc010ore.1_Nonsense_Mutation_p.K275*|ACADM_uc010orf.1_Nonsense_Mutation_p.K122*|ACADM_uc001dgx.3_Nonsense_Mutation_p.K225*|ACADM_uc010org.1_Nonsense_Mutation_p.K181*|ACADM_uc009wbs.1_RNA	NM_000016	NP_000007	P11310	ACADM_HUMAN	medium-chain acyl-CoA dehydrogenase isoform a	311					carnitine biosynthetic process|carnitine metabolic process, CoA-linked|fatty acid beta-oxidation using acyl-CoA dehydrogenase|medium-chain fatty acid catabolic process	mitochondrial matrix	flavin adenine dinucleotide binding|identical protein binding|medium-chain-acyl-CoA dehydrogenase activity			breast(2)|ovary(1)|skin(1)	4						AACTTTCGGAAAGCTACTTGT	0.333			NA											7	11					0	0	0.001984	0	0
MSH4	4438	broad.mit.edu	37	1	76343962	76343962	+	Missense_Mutation	SNP	T	T	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr1:76343962T>A	uc001dhd.1	+	11	1540	c.1499T>A	c.(1498-1500)ATA>AAA	p.I500K		NM_002440	NP_002431	O15457	MSH4_HUMAN	mutS homolog 4	500					chiasma assembly|homologous chromosome segregation|mismatch repair|reciprocal meiotic recombination	synaptonemal complex	ATP binding|DNA-dependent ATPase activity|mismatched DNA binding			lung(3)|ovary(2)	5						TTTCTTGACATAGCAAGAAGA	0.348			NA						MMR					9	14					0	0	0.006214	0	0
MSH4	4438	broad.mit.edu	37	1	76349447	76349447	+	Missense_Mutation	SNP	T	T	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr1:76349447T>A	uc001dhd.1	+	15	2089	c.2048T>A	c.(2047-2049)ATG>AAG	p.M683K		NM_002440	NP_002431	O15457	MSH4_HUMAN	mutS homolog 4	683	ATP (Potential).				chiasma assembly|homologous chromosome segregation|mismatch repair|reciprocal meiotic recombination	synaptonemal complex	ATP binding|DNA-dependent ATPase activity|mismatched DNA binding			lung(3)|ovary(2)	5						GGACCAAACATGAGTGGAAAA	0.343			NA						MMR					9	19					0	0	0.008291	0	0
TTLL7	79739	broad.mit.edu	37	1	84399443	84399443	+	Missense_Mutation	SNP	C	C	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr1:84399443C>A	uc001djc.2	-	9	1291	c.895G>T	c.(895-897)GTG>TTG	p.V299L	TTLL7_uc001djb.2_RNA|TTLL7_uc001djd.2_RNA|TTLL7_uc001dje.2_RNA|TTLL7_uc001djf.2_RNA|TTLL7_uc001djg.2_RNA	NM_024686	NP_078962	Q6ZT98	TTLL7_HUMAN	tubulin tyrosine ligase-like family, member 7	299	TTL.				cell differentiation|nervous system development|protein modification process	cilium|dendrite|microtubule basal body|perikaryon	tubulin-tyrosine ligase activity			ovary(1)	1				all cancers(265;0.0126)|Epithelial(280;0.0372)|OV - Ovarian serous cystadenocarcinoma(397;0.16)		GTCTTTACCACCAATTCCTAT	0.443			NA											10	34					3.07112e-06	3.46216e-06	0.010729	1	0
COL24A1	255631	broad.mit.edu	37	1	86578265	86578265	+	Silent	SNP	T	T	C			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr1:86578265T>C	uc001dlj.2	-	5	1626	c.1584A>G	c.(1582-1584)GGA>GGG	p.G528G	COL24A1_uc010osd.1_5'UTR|COL24A1_uc001dlk.2_RNA|COL24A1_uc010ose.1_RNA|COL24A1_uc010osf.1_RNA|COL24A1_uc009wcq.2_Silent_p.G528G	NM_152890	NP_690850	Q17RW2	COOA1_HUMAN	collagen, type XXIV, alpha 1 precursor	528	Collagen-like 1.				cell adhesion	collagen	extracellular matrix structural constituent			ovary(3)|central_nervous_system(1)|skin(1)	5				all cancers(265;0.0627)|Epithelial(280;0.0689)		GACCAGGTAATCCAGGTAAAC	0.388			NA											13	39					0	0	0.013537	0	0
PKN2	5586	broad.mit.edu	37	1	89294166	89294166	+	Missense_Mutation	SNP	A	A	G			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr1:89294166A>G	uc001dmn.2	+	19	2764	c.2422A>G	c.(2422-2424)ATG>GTG	p.M808V	PKN2_uc010osp.1_Missense_Mutation_p.M792V|PKN2_uc010osq.1_Missense_Mutation_p.M651V|PKN2_uc009wcv.2_Missense_Mutation_p.M760V|PKN2_uc010osr.1_Missense_Mutation_p.M473V	NM_006256	NP_006247	Q16513	PKN2_HUMAN	protein kinase N2	808	Protein kinase.				signal transduction	cytoplasm	ATP binding|histone deacetylase binding|protein kinase C activity			large_intestine(1)|lung(1)|skin(1)	3		Lung NSC(277;0.123)		all cancers(265;0.0136)|Epithelial(280;0.0301)		TTTTCCAGGAATGGGATATGG	0.343			NA											5	23					0	0	0.001168	0	0
ABCA4	24	broad.mit.edu	37	1	94544950	94544950	+	Silent	SNP	C	C	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr1:94544950C>A	uc001dqh.2	-	9	1271	c.1167G>T	c.(1165-1167)GCG>GCT	p.A389A	ABCA4_uc010otn.1_Silent_p.A389A	NM_000350	NP_000341	P78363	ABCA4_HUMAN	ATP-binding cassette, sub-family A member 4	389	Extracellular.				phototransduction, visible light|visual perception	integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(4)|skin(4)|central_nervous_system(2)|upper_aerodigestive_tract(1)|breast(1)	12		all_lung(203;0.000757)|Lung NSC(277;0.00335)		all cancers(265;0.00432)|GBM - Glioblastoma multiforme(16;0.00715)|Epithelial(280;0.171)		AAGGCTTTGCCGCCCTCCAAG	0.473			NA											21	43					4.96729e-08	5.87338e-08	0.008871	1	0
ABCA4	24	broad.mit.edu	37	1	94564460	94564460	+	Missense_Mutation	SNP	G	G	A	rs61748538		TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr1:94564460G>A	uc001dqh.2	-	6	762	c.658C>T	c.(658-660)CGC>TGC	p.R220C	ABCA4_uc010otn.1_Missense_Mutation_p.R220C	NM_000350	NP_000341	P78363	ABCA4_HUMAN	ATP-binding cassette, sub-family A member 4	220	Extracellular.		R -> C (in STGD1).		phototransduction, visible light|visual perception	integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(4)|skin(4)|central_nervous_system(2)|upper_aerodigestive_tract(1)|breast(1)	12		all_lung(203;0.000757)|Lung NSC(277;0.00335)		all cancers(265;0.00432)|GBM - Glioblastoma multiforme(16;0.00715)|Epithelial(280;0.171)		TTTGCCCCGCGTCTCTGGCTG	0.602			NA											14	64					0	0	0.004007	0	0
COL11A1	1301	broad.mit.edu	37	1	103487276	103487276	+	Missense_Mutation	SNP	G	G	C			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr1:103487276G>C	uc001dul.2	-	9	1613	c.1295C>G	c.(1294-1296)GCA>GGA	p.A432G	COL11A1_uc001duk.2_5'UTR|COL11A1_uc001dum.2_Missense_Mutation_p.A444G|COL11A1_uc001dun.2_Missense_Mutation_p.A393G|COL11A1_uc009weh.2_Missense_Mutation_p.A316G	NM_001854	NP_001845	P12107	COBA1_HUMAN	alpha 1 type XI collagen isoform A	432	Triple-helical region (interrupted).				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			ovary(6)|breast(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	12		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		CTCAACCACTGCTGGTTCTCC	0.353			NA											11	27					0	0	0.010729	0	0
AMY2B	280	broad.mit.edu	37	1	104114738	104114738	+	Missense_Mutation	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr1:104114738C>T	uc001duq.2	+	4	791	c.175C>T	c.(175-177)CCA>TCA	p.P59S	AMY2B_uc010ouo.1_RNA|LOC648740_uc001dur.2_Missense_Mutation_p.P59S	NM_020978	NP_066188	P19961	AMY2B_HUMAN	amylase, pancreatic, alpha-2B precursor	59					carbohydrate metabolic process|digestion	extracellular region	alpha-amylase activity|metal ion binding				0		all_epithelial(167;3.05e-05)|all_lung(203;0.000199)|Lung NSC(277;0.000451)		Colorectal(144;0.0669)|all cancers(265;0.083)|Epithelial(280;0.094)|Lung(183;0.112)		GTAGGTCTCTCCACCAAATGA	0.318			NA											10	39					0	0	0.008291	0	0
AMY2B	280	broad.mit.edu	37	1	104120405	104120405	+	Silent	SNP	G	G	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr1:104120405G>T	uc001duq.2	+	11	1900	c.1284G>T	c.(1282-1284)GGG>GGT	p.G428G	AMY2B_uc010ouo.1_RNA|LOC648740_uc001dur.2_Silent_p.G428G|AMY2B_uc001dus.1_RNA	NM_020978	NP_066188	P19961	AMY2B_HUMAN	amylase, pancreatic, alpha-2B precursor	428					carbohydrate metabolic process|digestion	extracellular region	alpha-amylase activity|metal ion binding				0		all_epithelial(167;3.05e-05)|all_lung(203;0.000199)|Lung NSC(277;0.000451)		Colorectal(144;0.0669)|all cancers(265;0.083)|Epithelial(280;0.094)|Lung(183;0.112)		ATGATAATGGGAGCAACCAAG	0.348			NA											18	69					1.00905e-13	1.30003e-13	0.008871	1	0
VAV3	10451	broad.mit.edu	37	1	108307757	108307757	+	Missense_Mutation	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr1:108307757C>T	uc001dvk.1	-	9	916	c.862G>A	c.(862-864)GCC>ACC	p.A288T	VAV3_uc010ouw.1_Missense_Mutation_p.A288T|VAV3_uc001dvl.1_Missense_Mutation_p.A112T|VAV3_uc010oux.1_Missense_Mutation_p.A288T	NM_006113	NP_006104	Q9UKW4	VAV3_HUMAN	vav 3 guanine nucleotide exchange factor isoform	288	DH.				angiogenesis|apoptosis|B cell receptor signaling pathway|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of B cell proliferation|regulation of Rho protein signal transduction|response to DNA damage stimulus|response to drug|small GTPase mediated signal transduction	cytosol	GTPase activator activity|metal ion binding|SH3/SH2 adaptor activity			ovary(5)|lung(2)|breast(2)	9		all_epithelial(167;5.38e-05)|all_lung(203;0.000314)|Lung NSC(277;0.000594)		Colorectal(144;0.0331)|Lung(183;0.128)|Epithelial(280;0.204)		CTAGAGATGGCTGACTCCACT	0.358			NA											6	18					0	0	0.001984	0	0
ATXN7L2	127002	broad.mit.edu	37	1	110030427	110030427	+	Splice_Site	SNP	G	G	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr1:110030427G>A	uc001dxr.2	+	5	715	c.700_splice	c.e5+1	p.R234_splice	ATXN7L2_uc001dxs.2_5'Flank	NM_153340	NP_699171	Q5T6C5	AT7L2_HUMAN	ataxin 7-like 2											ovary(2)	2		all_epithelial(167;0.00197)|all_lung(203;0.00291)|Lung NSC(277;0.00453)		Colorectal(144;0.0129)|Lung(183;0.0426)|Epithelial(280;0.0675)|READ - Rectum adenocarcinoma(129;0.0693)|all cancers(265;0.071)|LUSC - Lung squamous cell carcinoma(189;0.228)		AAGATGGCTCGTGAGTAGTTG	0.592			NA											5	52					0	0	0.000602	0	0
AHCYL1	10768	broad.mit.edu	37	1	110551679	110551679	+	Missense_Mutation	SNP	G	G	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr1:110551679G>A	uc001dyx.2	+	2	511	c.144G>A	c.(142-144)ATG>ATA	p.M48I	AHCYL1_uc010ovw.1_Missense_Mutation_p.M1I|AHCYL1_uc001dyy.2_Missense_Mutation_p.M1I|AHCYL1_uc010ovx.1_Missense_Mutation_p.M1I	NM_006621	NP_006612	O43865	SAHH2_HUMAN	S-adenosylhomocysteine hydrolase-like 1	48					one-carbon metabolic process	endoplasmic reticulum	adenosylhomocysteinase activity			ovary(1)	1		all_epithelial(167;3.58e-05)|all_lung(203;0.000116)|Lung NSC(277;0.000233)		Lung(183;0.0259)|Colorectal(144;0.123)|all cancers(265;0.134)|Epithelial(280;0.141)|LUSC - Lung squamous cell carcinoma(189;0.143)		CTGATGACATGCAGGAGTTCA	0.393			NA											9	30					0	0	0.004482	0	0
KCNA2	3737	broad.mit.edu	37	1	111147283	111147283	+	Missense_Mutation	SNP	C	C	G			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr1:111147283C>G	uc001dzu.2	-	2	618	c.122G>C	c.(121-123)GGG>GCG	p.G41A	KCNA2_uc009wfv.1_Missense_Mutation_p.G41A|KCNA2_uc009wfw.2_Missense_Mutation_p.G41A	NM_004974	NP_004965	P16389	KCNA2_HUMAN	potassium voltage-gated channel, shaker-related	41						juxtaparanode region of axon|voltage-gated potassium channel complex	delayed rectifier potassium channel activity			ovary(1)	1		all_cancers(81;5.55e-06)|all_epithelial(167;1.87e-05)|all_lung(203;0.000199)|Lung NSC(277;0.000398)		Colorectal(144;0.00878)|Lung(183;0.0234)|all cancers(265;0.0492)|Epithelial(280;0.0529)|COAD - Colon adenocarcinoma(174;0.131)|LUSC - Lung squamous cell carcinoma(189;0.133)|READ - Rectum adenocarcinoma(129;0.191)		AAACCGCAGCCCTGAGATGTT	0.572	Pancreas(18;568 735 10587 23710 36357)		NA											52	176					0	0	0.01441	0	0
ADORA3	140	broad.mit.edu	37	1	112031646	112031646	+	Missense_Mutation	SNP	T	T	G			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr1:112031646T>G	uc001ebf.2	-	3	1225	c.458A>C	c.(457-459)GAT>GCT	p.D153A	ADORA3_uc001ebg.3_Missense_Mutation_p.D72A	NM_020683	NP_065734	P33765	AA3R_HUMAN	adenosine A3 receptor isoform 1	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					activation of adenylate cyclase activity|inflammatory response|regulation of heart contraction	integral to plasma membrane	adenosine receptor activity, G-protein coupled			ovary(2)|large_intestine(1)|skin(1)	4		all_cancers(81;1.63e-06)|all_epithelial(167;5.01e-06)|all_lung(203;8.02e-05)|Lung NSC(277;0.000156)		all cancers(265;0.0185)|Colorectal(144;0.0186)|Lung(183;0.0238)|COAD - Colon adenocarcinoma(174;0.0644)|Epithelial(280;0.0872)|LUSC - Lung squamous cell carcinoma(189;0.134)	Adenosine(DB00640)|Aminophylline(DB01223)	GACCATGGCATCTGTGAAAac	0.363			NA											8	26					0	0	0.00308	0	0
PTGFRN	5738	broad.mit.edu	37	1	117491979	117491979	+	Missense_Mutation	SNP	G	G	T	rs149030409		TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr1:117491979G>T	uc001egv.1	+	4	1135	c.998G>T	c.(997-999)CGG>CTG	p.R333L		NM_020440	NP_065173	Q9P2B2	FPRP_HUMAN	prostaglandin F2 receptor negative regulator	333	Ig-like C2-type 3.|Extracellular (Potential).					endoplasmic reticulum membrane|Golgi apparatus|integral to membrane	protein binding			liver(1)	1	Lung SC(450;0.225)	all_cancers(81;0.00104)|all_lung(203;8.97e-05)|all_epithelial(167;0.000139)|Lung NSC(69;0.000446)		Lung(183;0.0704)|LUSC - Lung squamous cell carcinoma(189;0.227)|Colorectal(144;0.248)		GTGTTGGCGCGGCTTGACCGT	0.577			NA											20	59					5.03518e-11	6.27023e-11	0.007413	1	0
CD101	9398	broad.mit.edu	37	1	117552698	117552698	+	Silent	SNP	A	A	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr1:117552698A>T	uc010oxb.1	+	2	328	c.270A>T	c.(268-270)CGA>CGT	p.R90R	CD101_uc009whd.2_Silent_p.R90R|CD101_uc010oxc.1_Silent_p.R90R|CD101_uc010oxd.1_Silent_p.R90R	NM_004258	NP_004249	Q93033	IGSF2_HUMAN	immunoglobulin superfamily, member 2 precursor	90	Extracellular (Potential).|Ig-like C2-type 1.				cell surface receptor linked signaling pathway	integral to membrane|plasma membrane	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides			skin(2)|upper_aerodigestive_tract(1)|ovary(1)	4						AGCGGGTGCGAAGCGGAGACG	0.532			NA											6	43					0	0	0.001984	0	0
PDE4DIP	9659	broad.mit.edu	37	1	144923746	144923746	+	Missense_Mutation	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr1:144923746C>T	uc001elw.3	-	6	1003	c.712G>A	c.(712-714)GAT>AAT	p.D238N	NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|PDE4DIP_uc001elk.1_Intron|PDE4DIP_uc001ell.1_Intron|PDE4DIP_uc001elm.3_Intron|PDE4DIP_uc001eln.3_Intron|PDE4DIP_uc001elo.2_Intron|PDE4DIP_uc001elx.3_Missense_Mutation_p.D304N|PDE4DIP_uc001emc.1_Missense_Mutation_p.D238N|PDE4DIP_uc001emd.1_Missense_Mutation_p.D238N|PDE4DIP_uc001emb.1_Missense_Mutation_p.D401N|PDE4DIP_uc001eme.1_5'Flank|PDE4DIP_uc001emf.1_Missense_Mutation_p.D25N	NM_014644	NP_055459	Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein isoform	238	Potential.				cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			ovary(4)|haematopoietic_and_lymphoid_tissue(1)	5				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		AAGTGGGAATCAGATACAGAC	0.438			NA	T	PDGFRB	MPD								10	151					0	0	0.006214	0	0
GJA5	2702	broad.mit.edu	37	1	147230857	147230857	+	Missense_Mutation	SNP	C	C	G			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr1:147230857C>G	uc001eps.1	-	2	631	c.490G>C	c.(490-492)GAG>CAG	p.E164Q	GJA5_uc001ept.1_Missense_Mutation_p.E164Q	NM_181703	NP_859054	P36382	CXA5_HUMAN	connexin 40	164	Cytoplasmic (Potential).				angiogenesis|cell-cell junction assembly|muscle contraction	integral to membrane				ovary(1)	1	all_hematologic(923;0.0276)		LUSC - Lung squamous cell carcinoma(543;0.202)			AAGCCCACCTCCATGGTGGTG	0.577			NA											19	144					0	0	0.006122	0	0
FCGR1A	2209	broad.mit.edu	37	1	149762804	149762804	+	Missense_Mutation	SNP	C	C	G			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr1:149762804C>G	uc001esp.3	+	6	906	c.856C>G	c.(856-858)CCA>GCA	p.P286A	HIST2H2BF_uc010pbj.1_Intron|FCGR1A_uc009wlg.2_RNA	NM_000566	NP_000557	P12314	FCGR1_HUMAN	Fc fragment of IgG, high affinity Ia, receptor	286	Extracellular (Potential).				interferon-gamma-mediated signaling pathway|phagocytosis, engulfment	integral to membrane|plasma membrane	IgG binding|receptor activity|receptor signaling protein activity			ovary(1)	1	Breast(34;0.0124)|all_hematologic(923;0.127)				Abciximab(DB00054)|Adalimumab(DB00051)|Alefacept(DB00092)|Alemtuzumab(DB00087)|Basiliximab(DB00074)|Bevacizumab(DB00112)|Cetuximab(DB00002)|Daclizumab(DB00111)|Efalizumab(DB00095)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Methyl aminolevulinate(DB00992)|Muromonab(DB00075)|Natalizumab(DB00108)|Palivizumab(DB00110)|Porfimer(DB00707)|Rituximab(DB00073)|Tositumomab(DB00081)|Trastuzumab(DB00072)	CCTCCAGTTACCAACTCCTGT	0.423			NA											9	95					0	0	0.006214	0	0
HIST2H2AC	8338	broad.mit.edu	37	1	149858701	149858701	+	Silent	SNP	G	G	C			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr1:149858701G>C	uc001etd.2	+	1	177	c.177G>C	c.(175-177)CTG>CTC	p.L59L	HIST2H2BE_uc001etc.2_5'Flank	NM_003517	NP_003508	Q16777	H2A2C_HUMAN	histone cluster 2, H2ac	59					nucleosome assembly	nucleosome|nucleus	DNA binding			ovary(1)|skin(1)	2	Breast(34;0.0124)|all_hematologic(923;0.127)		STAD - Stomach adenocarcinoma(528;0.133)|LUSC - Lung squamous cell carcinoma(543;0.221)			TCGAGTACCTGACCGCCGAGA	0.687			NA											9	142					0	0	0.008291	0	0
SV2A	9900	broad.mit.edu	37	1	149882451	149882451	+	Silent	SNP	G	G	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr1:149882451G>A	uc001etg.2	-	4	1373	c.882C>T	c.(880-882)AGC>AGT	p.S294S	SV2A_uc001eth.2_Silent_p.S294S	NM_014849	NP_055664	Q7L0J3	SV2A_HUMAN	synaptic vesicle glycoprotein 2	294	Cytoplasmic (Potential).				neurotransmitter transport	cell junction|endoplasmic reticulum|integral to membrane|synaptic vesicle membrane	transmembrane transporter activity			ovary(6)|pancreas(1)	7	Breast(34;0.00769)|all_hematologic(923;0.127)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.221)|STAD - Stomach adenocarcinoma(528;0.247)		Levetiracetam(DB01202)	TGCAGAGCCAGCTCAAATGCT	0.542			NA											11	62					0	0	0.008291	0	0
RPRD2	23248	broad.mit.edu	37	1	150437062	150437062	+	Missense_Mutation	SNP	A	A	G			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr1:150437062A>G	uc009wlr.2	+	10	1672	c.1471A>G	c.(1471-1473)AGT>GGT	p.S491G	RPRD2_uc010pcc.1_Missense_Mutation_p.S465G|RPRD2_uc001eup.3_Missense_Mutation_p.S465G	NM_015203	NP_056018	Q5VT52	RPRD2_HUMAN	Regulation of nuclear pre-mRNA domain containing	491	Ser-rich.						protein binding			ovary(1)	1						CAACCTCACCAGTGGCCTGAA	0.527			NA									OREG0013786	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	8	6					0	0	0.00308	0	0
TARS2	80222	broad.mit.edu	37	1	150463952	150463952	+	Missense_Mutation	SNP	G	G	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr1:150463952G>A	uc001euq.2	+	5	602	c.595G>A	c.(595-597)GAG>AAG	p.E199K	TARS2_uc010pcd.1_RNA|TARS2_uc001eur.2_Missense_Mutation_p.E199K|TARS2_uc009wlt.2_Intron|TARS2_uc009wls.2_Missense_Mutation_p.E199K	NM_025150	NP_079426	Q9BW92	SYTM_HUMAN	threonyl-tRNA synthetase 2, mitochondrial	199					threonyl-tRNA aminoacylation	mitochondrial matrix	ATP binding|threonine-tRNA ligase activity			ovary(1)	1	all_cancers(9;3.13e-53)|all_epithelial(9;3.74e-43)|all_lung(15;2.43e-34)|Lung NSC(24;8.86e-31)|Breast(34;0.000326)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Melanoma(130;0.128)|Colorectal(459;0.171)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0757)|all cancers(9;1.51e-21)|BRCA - Breast invasive adenocarcinoma(12;0.000734)|LUSC - Lung squamous cell carcinoma(543;0.171)|STAD - Stomach adenocarcinoma(528;0.206)		L-Threonine(DB00156)	CCGGAGGCTAGAGGCTTCACG	0.532			NA											18	136					0	0	0.010504	0	0
CTSK	1513	broad.mit.edu	37	1	150772099	150772099	+	Silent	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr1:150772099C>T	uc001evp.1	-	6	829	c.705G>A	c.(703-705)CTG>CTA	p.L235L	CTSK_uc001evq.1_Silent_p.L146L	NM_000396	NP_000387	P43235	CATK_HUMAN	cathepsin K preproprotein	235					proteolysis	lysosome	cysteine-type endopeptidase activity|protein binding			skin(1)	1	all_cancers(9;2.32e-51)|all_epithelial(9;3.89e-42)|all_lung(15;4.59e-35)|Lung NSC(24;1.7e-31)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Colorectal(459;0.171)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0485)|BRCA - Breast invasive adenocarcinoma(12;0.00606)|LUSC - Lung squamous cell carcinoma(543;0.211)			CTGCCCTCTTCAGGGCTTTCT	0.517			NA											5	146					0	0	0.000602	0	0
SETDB1	9869	broad.mit.edu	37	1	150935522	150935522	+	Missense_Mutation	SNP	C	C	G			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr1:150935522C>G	uc001evu.2	+	19	3554	c.3364C>G	c.(3364-3366)CAG>GAG	p.Q1122E	SETDB1_uc001evv.2_Missense_Mutation_p.Q1122E|SETDB1_uc009wmg.1_Missense_Mutation_p.Q1122E	NM_001145415	NP_001138887	Q15047	SETB1_HUMAN	SET domain, bifurcated 1 isoform 1	1122	SET.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|Golgi apparatus|nucleus|plasma membrane	DNA binding|histone-lysine N-methyltransferase activity|protein binding|zinc ion binding			ovary(2)|upper_aerodigestive_tract(1)	3	all_lung(15;9e-35)|Lung NSC(24;3.45e-31)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.108)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|BRCA - Breast invasive adenocarcinoma(12;0.0152)|LUSC - Lung squamous cell carcinoma(543;0.211)			CACTGCTGGTCAGACTTCGGC	0.532			NA											25	34					0	0	0.00333	0	0
SNX27	81609	broad.mit.edu	37	1	151641082	151641082	+	Missense_Mutation	SNP	G	G	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr1:151641082G>A	uc001eyn.1	+	7	1136	c.1120G>A	c.(1120-1122)GAC>AAC	p.D374N	SNX27_uc001eyo.2_Missense_Mutation_p.D281N|SNX27_uc001eyp.2_Missense_Mutation_p.D188N	NM_030918	NP_112180	Q96L92	SNX27_HUMAN	sorting nexin family member 27	374					cell communication|protein transport|signal transduction	cytosol|early endosome	phosphatidylinositol binding|protein binding			ovary(2)|central_nervous_system(1)	3	Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		LUSC - Lung squamous cell carcinoma(543;0.181)			AAATGACAATGACCTTGCTGT	0.343	Colon(46;291 966 40145 41237 41888)		NA											8	53					0	0	0.004482	0	0
TCHHL1	126637	broad.mit.edu	37	1	152057927	152057927	+	Nonsense_Mutation	SNP	G	G	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr1:152057927G>T	uc001ezo.1	-	3	2296	c.2231C>A	c.(2230-2232)TCA>TAA	p.S744*		NM_001008536	NP_001008536	Q5QJ38	TCHL1_HUMAN	trichohyalin-like 1	744							calcium ion binding			ovary(1)|skin(1)	2	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.246)			TTCCTCCTCTGATGTTACAGG	0.468			NA											23	169					6.32553e-13	8.0638e-13	0.004656	1	0
TCHHL1	126637	broad.mit.edu	37	1	152059275	152059275	+	Missense_Mutation	SNP	T	T	C			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr1:152059275T>C	uc001ezo.1	-	3	948	c.883A>G	c.(883-885)AGA>GGA	p.R295G		NM_001008536	NP_001008536	Q5QJ38	TCHL1_HUMAN	trichohyalin-like 1	295							calcium ion binding			ovary(1)|skin(1)	2	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.246)			TCATCTTCTCTTTGTAGGGGT	0.443			NA											166	166					0	0	0.01441	0	0
TCHH	7062	broad.mit.edu	37	1	152083697	152083697	+	Missense_Mutation	SNP	C	C	G			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr1:152083697C>G	uc001ezp.2	-	2	1996	c.1996G>C	c.(1996-1998)GAG>CAG	p.E666Q	TCHH_uc009wne.1_Missense_Mutation_p.E666Q	NM_007113	NP_009044	Q07283	TRHY_HUMAN	trichohyalin	666	9 X 28 AA approximate tandem repeats.				keratinization	cytoskeleton	calcium ion binding			ovary(3)|kidney(1)|central_nervous_system(1)	5	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TCGAGCCTCTCTTCCTCCTCC	0.652			NA											59	98					0	0	0.01441	0	0
HRNR	388697	broad.mit.edu	37	1	152187607	152187607	+	Silent	SNP	G	G	C			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr1:152187607G>C	uc001ezt.1	-	3	6574	c.6498C>G	c.(6496-6498)TCC>TCG	p.S2166S		NM_001009931	NP_001009931	Q86YZ3	HORN_HUMAN	hornerin	2166	24.				keratinization		calcium ion binding|protein binding			skin(2)|ovary(1)	3	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			AAGACTGACGGGAGCCAGACC	0.632			NA											22	805					0	0	0.004656	0	0
FLG	2312	broad.mit.edu	37	1	152281538	152281538	+	Missense_Mutation	SNP	G	G	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr1:152281538G>T	uc001ezu.1	-	3	5860	c.5824C>A	c.(5824-5826)CAT>AAT	p.H1942N		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	1942	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GATCCAAGATGGTTTCTGGAA	0.572			NA							Ichthyosis				260	359					6.0155e-110	8.50487e-110	0.01441	1	0
FLG	2312	broad.mit.edu	37	1	152285143	152285143	+	Missense_Mutation	SNP	C	C	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr1:152285143C>A	uc001ezu.1	-	3	2255	c.2219G>T	c.(2218-2220)CGA>CTA	p.R740L	uc001ezv.2_5'Flank	NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	740	Filaggrin 4.|Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			ACTGGACCCTCGGTGTCCACT	0.577			NA							Ichthyosis				92	673					3.28864e-39	4.61809e-39	0.01441	1	0
KPRP	448834	broad.mit.edu	37	1	152733553	152733553	+	Missense_Mutation	SNP	A	A	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr1:152733553A>T	uc001fal.1	+	2	1547	c.1489A>T	c.(1489-1491)AGC>TGC	p.S497C		NM_001025231	NP_001020402	Q5T749	KPRP_HUMAN	keratinocyte proline-rich protein	497	Pro-rich.					cytoplasm				ovary(4)|pancreas(1)	5	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			GACTTGGCGCAGCCCCAGCCC	0.647			NA											80	60					0	0	0.01441	0	0
NUP210L	91181	broad.mit.edu	37	1	154067433	154067433	+	Missense_Mutation	SNP	T	T	G			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr1:154067433T>G	uc001fdw.2	-	15	2237	c.2165A>C	c.(2164-2166)CAA>CCA	p.Q722P	NUP210L_uc009woq.2_5'UTR|NUP210L_uc010peh.1_Missense_Mutation_p.Q722P	NM_207308	NP_997191	Q5VU65	P210L_HUMAN	nucleoporin 210kDa-like isoform 1	722						integral to membrane				skin(5)|ovary(4)|large_intestine(1)|central_nervous_system(1)	11	all_lung(78;9.35e-31)|Lung NSC(65;1.33e-28)|Hepatocellular(266;0.0877)|Melanoma(130;0.128)		LUSC - Lung squamous cell carcinoma(543;0.151)|Colorectal(543;0.198)			ATCCAGGCATTGGATCCGGTA	0.383			NA											5	30					0	0	0.000602	0	0
PYGO2	90780	broad.mit.edu	37	1	154931475	154931475	+	Missense_Mutation	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr1:154931475C>T	uc001fft.2	-	3	1207	c.1001G>A	c.(1000-1002)CGG>CAG	p.R334Q	PBXIP1_uc001ffr.2_5'Flank|PBXIP1_uc001ffs.2_5'Flank|PBXIP1_uc010pep.1_5'Flank	NM_138300	NP_612157	Q9BRQ0	PYGO2_HUMAN	pygopus homolog 2	334	PHD-type.				Wnt receptor signaling pathway	nucleus	protein binding|zinc ion binding			skin(1)	1	all_epithelial(22;4.9e-30)|all_lung(78;4.1e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)|all_neural(408;0.245)		BRCA - Breast invasive adenocarcinoma(34;0.00034)			CACCTCACTCCGACAGGCACC	0.632	NSCLC(87;357 1460 1955 21029 23522)		NA											10	70					0	0	0.010729	0	0
SYT11	23208	broad.mit.edu	37	1	155838184	155838184	+	Missense_Mutation	SNP	G	G	C			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr1:155838184G>C	uc001fmg.2	+	2	726	c.463G>C	c.(463-465)GAT>CAT	p.D155H	SYT11_uc010pgq.1_Intron	NM_152280	NP_689493	Q9BT88	SYT11_HUMAN	synaptotagmin XI	155	Cytoplasmic (Potential).					cell junction|synaptic vesicle membrane	protein binding|transporter activity			ovary(1)|skin(1)	2	Hepatocellular(266;0.133)|all_hematologic(923;0.145)|all_neural(408;0.195)		OV - Ovarian serous cystadenocarcinoma(3;0.000162)			TCCAGAGGAGGATGTCATGCT	0.517			NA											27	165					0	0	0.003954	0	0
C1orf61	10485	broad.mit.edu	37	1	156384530	156384530	+	Silent	SNP	C	C	G	rs144548564		TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr1:156384530C>G	uc001fou.1	-	4	204	c.87G>C	c.(85-87)GCG>GCC	p.A29A	C1orf61_uc001fov.1_RNA|C1orf61_uc001fow.1_Intron|C1orf61_uc001fox.1_RNA|C1orf61_uc001foy.1_RNA	NM_006365	NP_006356	Q13536	CROC4_HUMAN	transcriptional activator of the c-fos promoter	29						nucleus				skin(1)	1	Hepatocellular(266;0.158)					AGAACCCACCCGCCCCAGGTG	0.532			NA											5	17					0	0	0.000602	0	0
MEF2D	4209	broad.mit.edu	37	1	156437954	156437954	+	Missense_Mutation	SNP	G	G	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr1:156437954G>A	uc001fpc.2	-	11	1775	c.1385C>T	c.(1384-1386)GCC>GTC	p.A462V	MEF2D_uc001fpb.2_Missense_Mutation_p.A455V|MEF2D_uc001fpd.2_Missense_Mutation_p.A455V|MEF2D_uc001fpe.1_Missense_Mutation_p.A462V|MEF2D_uc009wsa.2_RNA	NM_005920	NP_005911	Q14814	MEF2D_HUMAN	myocyte enhancer factor 2D	462					apoptosis|muscle organ development|nervous system development|positive regulation of transcription from RNA polymerase II promoter	nucleus	activating transcription factor binding|histone deacetylase binding|RNA polymerase II regulatory region sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity			ovary(1)	1	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					CTCAGGGCGGGCAGCTGGGAA	0.682			NA											15	105					0	0	0.00245	0	0
TTC24	164118	broad.mit.edu	37	1	156554719	156554719	+	Missense_Mutation	SNP	G	G	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr1:156554719G>T	uc009wsc.1	+	5	602	c.462G>T	c.(460-462)GAG>GAT	p.E154D		NM_001105669	NP_001099139	A2A3L6	TTC24_HUMAN	tetratricopeptide repeat domain 24	434							binding			pancreas(1)	1	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					GCCAGGCGGAGGGGACCCCAG	0.612			NA											9	4					1.76689e-08	2.10981e-08	0.006214	1	0
BCAN	63827	broad.mit.edu	37	1	156618623	156618623	+	Missense_Mutation	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr1:156618623C>T	uc001fpp.2	+	6	1369	c.1033C>T	c.(1033-1035)CAC>TAC	p.H345Y	BCAN_uc001fpo.2_Missense_Mutation_p.H345Y	NM_021948	NP_068767	Q96GW7	PGCB_HUMAN	brevican isoform 1	345	Link 2.				cell adhesion	anchored to membrane|proteinaceous extracellular matrix	hyaluronic acid binding|sugar binding			ovary(1)|pancreas(1)	2	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					CCCCAATAAGCACAGCCGCTT	0.577			NA											111	104					0	0	0.01441	0	0
SH2D2A	9047	broad.mit.edu	37	1	156776986	156776986	+	Missense_Mutation	SNP	A	A	C			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr1:156776986A>C	uc001fqd.2	-	8	1294	c.1154T>G	c.(1153-1155)CTT>CGT	p.L385R	SH2D2A_uc001fqc.1_Missense_Mutation_p.L357R|SH2D2A_uc009wsh.2_Missense_Mutation_p.L395R|SH2D2A_uc001fqe.2_Missense_Mutation_p.L367R|SH2D2A_uc010phs.1_Missense_Mutation_p.L385R	NM_003975	NP_003966	Q9NP31	SH22A_HUMAN	SH2 domain protein 2A isoform 2	385	Pro-rich.				angiogenesis|cell differentiation|signal transduction	cytoplasm|soluble fraction	SH3 domain binding|SH3/SH2 adaptor activity				0	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					AGGAGGCCCAAGGGGAAGCCA	0.582			NA											56	86					0	0	0.01441	0	0
SH2D2A	9047	broad.mit.edu	37	1	156776988	156776988	+	Silent	SNP	G	G	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr1:156776988G>A	uc001fqd.2	-	8	1292	c.1152C>T	c.(1150-1152)CCC>CCT	p.P384P	SH2D2A_uc001fqc.1_Silent_p.P356P|SH2D2A_uc009wsh.2_Silent_p.P394P|SH2D2A_uc001fqe.2_Silent_p.P366P|SH2D2A_uc010phs.1_Silent_p.P384P	NM_003975	NP_003966	Q9NP31	SH22A_HUMAN	SH2 domain protein 2A isoform 2	384	Pro-rich.				angiogenesis|cell differentiation|signal transduction	cytoplasm|soluble fraction	SH3 domain binding|SH3/SH2 adaptor activity				0	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					GAGGCCCAAGGGGAAGCCATG	0.592			NA											55	87					0	0	0.01441	0	0
SH2D2A	9047	broad.mit.edu	37	1	156779566	156779566	+	Missense_Mutation	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr1:156779566C>T	uc001fqd.2	-	6	741	c.601G>A	c.(601-603)GAA>AAA	p.E201K	SH2D2A_uc001fqc.1_Missense_Mutation_p.E173K|SH2D2A_uc009wsh.2_Missense_Mutation_p.E211K|SH2D2A_uc001fqe.2_Missense_Mutation_p.E183K|SH2D2A_uc010phs.1_Missense_Mutation_p.E201K	NM_003975	NP_003966	Q9NP31	SH22A_HUMAN	SH2 domain protein 2A isoform 2	201	Pro-rich.				angiogenesis|cell differentiation|signal transduction	cytoplasm|soluble fraction	SH3 domain binding|SH3/SH2 adaptor activity				0	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					TTTGATTCTTCGGTCCTCAGG	0.582			NA											41	236					0	0	0.009718	0	0
FCRL5	83416	broad.mit.edu	37	1	157491004	157491004	+	Missense_Mutation	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr1:157491004C>T	uc001fqu.2	-	11	2476	c.2318G>A	c.(2317-2319)TGT>TAT	p.C773Y	FCRL5_uc009wsm.2_Missense_Mutation_p.C773Y	NM_031281	NP_112571	Q96RD9	FCRL5_HUMAN	Fc receptor-like 5	773	Extracellular (Potential).|Ig-like C2-type 8.					integral to membrane|plasma membrane	receptor activity			ovary(3)|breast(2)|central_nervous_system(1)	6	all_hematologic(112;0.0378)|Hepatocellular(266;0.178)	Prostate(1639;0.231)				CAGGGCCTCACAGTGAAGCTC	0.582			NA											12	86					0	0	0.010729	0	0
FCRL4	83417	broad.mit.edu	37	1	157551323	157551323	+	Nonsense_Mutation	SNP	G	G	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr1:157551323G>T	uc001fqw.2	-	7	1383	c.1247C>A	c.(1246-1248)TCA>TAA	p.S416*	FCRL4_uc010phy.1_RNA	NM_031282	NP_112572	Q96PJ5	FCRL4_HUMAN	Fc receptor-like 4 precursor	416	Cytoplasmic (Potential).					integral to membrane|plasma membrane	receptor activity			ovary(2)|kidney(1)|skin(1)	4	all_hematologic(112;0.0378)|Hepatocellular(266;0.178)	Prostate(1639;0.245)				GCACAAACCTGACTTCCTCCG	0.592			NA											36	31					1.836e-18	2.45703e-18	0.003755	1	0
OR10K1	391109	broad.mit.edu	37	1	158435500	158435500	+	Missense_Mutation	SNP	T	T	C			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr1:158435500T>C	uc010pij.1	+	1	149	c.149T>C	c.(148-150)GTG>GCG	p.V50A		NM_001004473	NP_001004473	Q8NGX5	O10K1_HUMAN	olfactory receptor, family 10, subfamily K,	50	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	all_hematologic(112;0.0378)					TCCACCATTGTGCTGGACAGA	0.483			NA											4	142					0	0	0.001168	0	0
OR6K3	391114	broad.mit.edu	37	1	158687653	158687653	+	Missense_Mutation	SNP	G	G	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr1:158687653G>T	uc010pip.1	-	1	301	c.301C>A	c.(301-303)CTC>ATC	p.L101I		NM_001005327	NP_001005327	Q8NGY3	OR6K3_HUMAN	olfactory receptor, family 6, subfamily K,	101	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|kidney(1)|central_nervous_system(1)	3	all_hematologic(112;0.0378)					TCACTGATGAGGTTGGAGAGC	0.453			NA											16	150					1.3612e-06	1.55873e-06	0.003163	1	0
IFI16	3428	broad.mit.edu	37	1	158988421	158988421	+	Missense_Mutation	SNP	G	G	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr1:158988421G>T	uc001ftf.1	+	6	1559	c.952G>T	c.(952-954)GGG>TGG	p.G318W	IFI16_uc001ftg.2_Missense_Mutation_p.G318W|IFI16_uc010pis.1_Missense_Mutation_p.G262W	NM_005531	NP_005522	Q16666	IF16_HUMAN	interferon, gamma-inducible protein 16	318	HIN-200 1.				cell proliferation|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|monocyte differentiation|negative regulation of transcription, DNA-dependent|response to virus|transcription, DNA-dependent	cytoplasm|nuclear speck|nucleolus	double-stranded DNA binding|protein binding			ovary(1)	1	all_hematologic(112;0.0429)					TATTGTATATGGGGTATTTAT	0.338			NA											8	68					5.4927e-09	6.63511e-09	0.004482	1	0
ATP1A2	477	broad.mit.edu	37	1	160098582	160098582	+	Silent	SNP	C	C	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr1:160098582C>A	uc001fvc.2	+	9	1290	c.1158C>A	c.(1156-1158)GTC>GTA	p.V386V	ATP1A2_uc001fvb.2_Silent_p.V386V|ATP1A2_uc010piz.1_Silent_p.V231V|ATP1A2_uc001fvd.2_Silent_p.V122V|ATP1A2_uc009wtg.1_Silent_p.V74V	NM_000702	NP_000693	P50993	AT1A2_HUMAN	Na+/K+ -ATPase alpha 2 subunit proprotein	386	Cytoplasmic (Potential).				ATP biosynthetic process		ATP binding|metal ion binding|sodium:potassium-exchanging ATPase activity			central_nervous_system(3)|ovary(2)|skin(2)	7	all_cancers(52;1.11e-16)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)|LUSC - Lung squamous cell carcinoma(543;0.246)			GCATGACCGTCGCCCACATGT	0.597			NA											13	88					0.000219431	0.000235836	0.00245	1	0
CASQ1	844	broad.mit.edu	37	1	160164856	160164856	+	Missense_Mutation	SNP	G	G	C			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr1:160164856G>C	uc010pja.1	+	4	777	c.520G>C	c.(520-522)GAG>CAG	p.E174Q		NM_001231	NP_001222	P31415	CASQ1_HUMAN	calsequestrin 1	174						mitochondrial matrix|sarcoplasmic reticulum lumen|smooth endoplasmic reticulum	calcium ion binding			central_nervous_system(1)	1	all_cancers(52;2.56e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			GCAGGCGTTTGAGAATATTGA	0.493			NA											37	18					0	0	0.004878	0	0
DCAF8	50717	broad.mit.edu	37	1	160209914	160209914	+	Nonsense_Mutation	SNP	G	G	C			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr1:160209914G>C	uc001fvo.2	-	4	608	c.296C>G	c.(295-297)TCA>TGA	p.S99*	DCAF8_uc001fvn.2_Nonsense_Mutation_p.S99*|DCAF8_uc009wth.2_Nonsense_Mutation_p.S99*|DCAF8_uc010pjb.1_Nonsense_Mutation_p.S99*|DCAF8_uc010pjc.1_Nonsense_Mutation_p.S253*|DCAF8_uc001fvq.3_Nonsense_Mutation_p.S99*|DCAF8_uc001fvp.3_Nonsense_Mutation_p.S99*|uc010pjd.1_3'UTR	NM_015726	NP_056541	Q5TAQ9	DCAF8_HUMAN	DDB1 and CUL4 associated factor 8	99						CUL4 RING ubiquitin ligase complex	protein binding			skin(2)	2						ctcttcctctGAGCGGTCATG	0.428			NA											23	27					0	0	0.012319	0	0
HSPA6	3310	broad.mit.edu	37	1	161495729	161495729	+	Silent	SNP	C	C	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr1:161495729C>A	uc001gap.2	+	2	1941	c.1281C>A	c.(1279-1281)ACC>ACA	p.T427T	HSPA6_uc001gaq.2_Silent_p.T427T	NM_002155	NP_002146	P17066	HSP76_HUMAN	heat shock 70kDa protein 6 (HSP70B')	427					response to unfolded protein		ATP binding			skin(1)	1	all_cancers(52;4.89e-16)|all_hematologic(112;0.0207)		BRCA - Breast invasive adenocarcinoma(70;0.00376)			CCAAGCAGACCCAGACTTTCA	0.597			NA											52	33					2.17126e-26	2.99398e-26	0.01441	1	0
HSPA6	3310	broad.mit.edu	37	1	161496369	161496369	+	Missense_Mutation	SNP	G	G	A	rs144080022		TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr1:161496369G>A	uc001gap.2	+	2	2581	c.1921G>A	c.(1921-1923)GAG>AAG	p.E641K	HSPA6_uc001gaq.2_Missense_Mutation_p.E641K	NM_002155	NP_002146	P17066	HSP76_HUMAN	heat shock 70kDa protein 6 (HSP70B')	641					response to unfolded protein		ATP binding			skin(1)	1	all_cancers(52;4.89e-16)|all_hematologic(112;0.0207)		BRCA - Breast invasive adenocarcinoma(70;0.00376)			CATCATTGAGGAGGTTGATTG	0.582			NA											5	50					0	0	0.001168	0	0
ADCY10	55811	broad.mit.edu	37	1	167830153	167830153	+	Missense_Mutation	SNP	C	C	G			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr1:167830153C>G	uc001ger.2	-	15	2063	c.1765G>C	c.(1765-1767)GAT>CAT	p.D589H	ADCY10_uc009wvk.2_Missense_Mutation_p.D497H|ADCY10_uc010plj.1_Missense_Mutation_p.D436H|ADCY10_uc009wvl.2_Missense_Mutation_p.D588H	NM_018417	NP_060887	Q96PN6	ADCYA_HUMAN	adenylate cyclase 10	589					intracellular signal transduction|spermatogenesis	cytoskeleton|cytosol|perinuclear region of cytoplasm|plasma membrane|soluble fraction	adenylate cyclase activity|ATP binding|magnesium ion binding			central_nervous_system(2)|ovary(1)	3						AACTTTTCATCCAACAGTGTC	0.403			NA											12	70					0	0	0.001855	0	0
F5	2153	broad.mit.edu	37	1	169528470	169528470	+	Silent	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr1:169528470C>T	uc001ggg.1	-	5	796	c.651G>A	c.(649-651)GTG>GTA	p.V217V	F5_uc010plr.1_RNA	NM_000130	NP_000121	P12259	FA5_HUMAN	coagulation factor V precursor	217	F5/8 type A 1.|Plastocyanin-like 2.				cell adhesion|platelet activation|platelet degranulation	plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity			ovary(3)|large_intestine(1)|central_nervous_system(1)|skin(1)	6	all_hematologic(923;0.208)				Drotrecogin alfa(DB00055)	TTTCATCAAACACAGCAAATA	0.463			NA											28	26					0	0	0.00632	0	0
FMO1	2326	broad.mit.edu	37	1	171250036	171250036	+	Missense_Mutation	SNP	C	C	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr1:171250036C>A	uc009wvz.2	+	6	875	c.739C>A	c.(739-741)CTC>ATC	p.L247I	FMO1_uc010pme.1_Missense_Mutation_p.L184I|FMO1_uc001ghl.2_Missense_Mutation_p.L247I|FMO1_uc001ghm.2_Missense_Mutation_p.L247I|FMO1_uc001ghn.2_Missense_Mutation_p.L247I	NM_002021	NP_002012	Q01740	FMO1_HUMAN	flavin containing monooxygenase 1	247					NADPH oxidation|organic acid metabolic process|toxin metabolic process|xenobiotic metabolic process	endoplasmic reticulum lumen|integral to membrane|intrinsic to endoplasmic reticulum membrane|microsome	flavin adenine dinucleotide binding|flavin-containing monooxygenase activity|NADP binding			skin(1)	1	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					GAGAAATTCCCTCCCAACCCC	0.468			NA											13	52					9.05144e-12	1.14086e-11	0.001855	1	0
METTL13	51603	broad.mit.edu	37	1	171756899	171756899	+	Missense_Mutation	SNP	G	G	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr1:171756899G>A	uc001ghz.2	+	4	1485	c.1138G>A	c.(1138-1140)GAC>AAC	p.D380N	METTL13_uc001gia.2_Missense_Mutation_p.D294N|METTL13_uc001gib.2_Missense_Mutation_p.D224N|METTL13_uc010pml.1_Missense_Mutation_p.D379N	NM_015935	NP_057019	Q8N6R0	MTL13_HUMAN	CGI-01 protein isoform 1	380							methyltransferase activity|protein binding			kidney(1)	1						TGTGGGTGGGGACATTGGGGT	0.502			NA											5	43					0	0	0.001984	0	0
SLC9A11	284525	broad.mit.edu	37	1	173567171	173567171	+	Missense_Mutation	SNP	C	C	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr1:173567171C>A	uc001giz.2	-	4	652	c.229G>T	c.(229-231)GTG>TTG	p.V77L	SLC9A11_uc010pmq.1_RNA	NM_178527	NP_848622	Q5TAH2	S9A11_HUMAN	solute carrier family 9, member 11	77					sodium ion transport	integral to membrane	ion channel activity|solute:hydrogen antiporter activity			ovary(2)	2						ATTTGGTGCACCTAAAGTAAC	0.299			NA											4	18					0.00024832	0.000265313	0.009096	1	0
KLHL20	27252	broad.mit.edu	37	1	173703396	173703396	+	Missense_Mutation	SNP	G	G	C			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr1:173703396G>C	uc001gjc.2	+	3	747	c.568G>C	c.(568-570)GAC>CAC	p.D190H	KLHL20_uc010pmr.1_Intron|KLHL20_uc009wwf.2_Missense_Mutation_p.D172H|KLHL20_uc001gjd.2_Missense_Mutation_p.D190H	NM_014458	NP_055273	Q9Y2M5	KLH20_HUMAN	kelch-like 20	190	BACK.				cytoskeleton organization|negative regulation of apoptosis|proteasomal ubiquitin-dependent protein catabolic process|response to interferon-alpha	actin cytoskeleton|cell surface|Cul3-RING ubiquitin ligase complex|Golgi apparatus|perinuclear region of cytoplasm|PML body	actin binding|interferon-gamma binding|ubiquitin-protein ligase activity			ovary(1)	1						AAGGATAGCAGACAAGTTCAC	0.428	GBM(159;862 2695 6559 23041)		NA											16	21					0	0	0.003163	0	0
RFWD2	64326	broad.mit.edu	37	1	175957454	175957454	+	Silent	SNP	G	G	A	rs142920790	byFrequency	TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr1:175957454G>A	uc001gku.1	-	17	2198	c.1942C>T	c.(1942-1944)CTG>TTG	p.L648L	RFWD2_uc001gkv.1_Silent_p.L624L|RFWD2_uc001gkw.1_Silent_p.L408L|RFWD2_uc009wwv.2_Silent_p.L447L|RFWD2_uc001gkt.1_Silent_p.L487L	NM_022457	NP_071902	Q8NHY2	RFWD2_HUMAN	ring finger and WD repeat domain 2 isoform a	648	WD 6.				DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	centrosome|cytosol|focal adhesion|nuclear speck	protein binding|ubiquitin-protein ligase activity|zinc ion binding				0						TTGGAAGCCAGGCCTACAAAG	0.398	Ovarian(134;1413 1765 5706 35534 51541)		NA											15	20					0	0	0.003163	0	0
ASTN1	460	broad.mit.edu	37	1	176838157	176838157	+	Missense_Mutation	SNP	G	G	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr1:176838157G>T	uc001glc.2	-	22	3682	c.3470C>A	c.(3469-3471)GCA>GAA	p.A1157E	ASTN1_uc001glb.1_Missense_Mutation_p.A1157E|ASTN1_uc001gld.1_Missense_Mutation_p.A1157E	NM_004319	NP_004310	O14525	ASTN1_HUMAN	astrotactin isoform 1	1165					cell migration|neuron cell-cell adhesion	integral to membrane				ovary(6)|skin(5)|central_nervous_system(2)|large_intestine(1)|lung(1)	15						GATCTTGTCTGCTATTTCTGA	0.333			NA											21	11					7.45023e-12	9.41491e-12	0.010504	1	0
ASTN1	460	broad.mit.edu	37	1	176915180	176915180	+	Missense_Mutation	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr1:176915180C>T	uc001glc.2	-	13	2343	c.2131G>A	c.(2131-2133)GAC>AAC	p.D711N	ASTN1_uc001glb.1_Missense_Mutation_p.D711N|ASTN1_uc001gld.1_Missense_Mutation_p.D711N|ASTN1_uc009wwx.1_Missense_Mutation_p.D711N	NM_004319	NP_004310	O14525	ASTN1_HUMAN	astrotactin isoform 1	719					cell migration|neuron cell-cell adhesion	integral to membrane				ovary(6)|skin(5)|central_nervous_system(2)|large_intestine(1)|lung(1)	15						TCCCCACAGTCACTTCCCTCT	0.532			NA											11	61					0	0	0.008291	0	0
ABL2	27	broad.mit.edu	37	1	179077723	179077723	+	Missense_Mutation	SNP	C	C	G			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr1:179077723C>G	uc001gmj.3	-	12	2966	c.2679G>C	c.(2677-2679)AAG>AAC	p.K893N	ABL2_uc010pnf.1_Missense_Mutation_p.K790N|ABL2_uc010png.1_Missense_Mutation_p.K769N|ABL2_uc010pnh.1_Missense_Mutation_p.K872N|ABL2_uc001gmg.3_Missense_Mutation_p.K775N|ABL2_uc001gmi.3_Missense_Mutation_p.K878N|ABL2_uc001gmh.3_Missense_Mutation_p.K857N|ABL2_uc010pne.1_Missense_Mutation_p.K754N	NM_007314	NP_009298	P42684	ABL2_HUMAN	arg tyrosine kinase isoform b	893	F-actin-binding (By similarity).|Pro-rich.				axon guidance|cell adhesion|peptidyl-tyrosine phosphorylation|positive regulation of oxidoreductase activity|signal transduction	cytoskeleton|cytosol	ATP binding|magnesium ion binding|manganese ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding			lung(8)|breast(3)|ovary(2)|central_nervous_system(1)	14					Adenosine triphosphate(DB00171)|Dasatinib(DB01254)	CCCCACCATTCTTCTCTTTAC	0.617			NA	T	ETV6	AML								35	47					0	0	0.013726	0	0
HMCN1	83872	broad.mit.edu	37	1	186014906	186014906	+	Missense_Mutation	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr1:186014906C>T	uc001grq.1	+	41	6620	c.6391C>T	c.(6391-6393)CCC>TCC	p.P2131S		NM_031935	NP_114141	Q96RW7	HMCN1_HUMAN	hemicentin 1 precursor	2131	Ig-like C2-type 19.				response to stimulus|visual perception	basement membrane	calcium ion binding			ovary(22)|skin(1)	23						TGATGCTATTCCCCCACCTAC	0.418			NA											4	36					0	0	0.009096	0	0
FAM5C	339479	broad.mit.edu	37	1	190068179	190068179	+	Missense_Mutation	SNP	G	G	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr1:190068179G>T	uc001gse.1	-	8	1502	c.1270C>A	c.(1270-1272)CAC>AAC	p.H424N	FAM5C_uc010pot.1_Missense_Mutation_p.H322N	NM_199051	NP_950252	Q76B58	FAM5C_HUMAN	family with sequence similarity 5, member C	424						extracellular region				lung(2)|ovary(1)|kidney(1)|skin(1)	5	Prostate(682;0.198)					GTGCACGAGTGCGTCTCTTCT	0.552			NA											11	29					4.68919e-08	5.56267e-08	0.008291	1	0
ASPM	259266	broad.mit.edu	37	1	197115467	197115467	+	Missense_Mutation	SNP	G	G	C			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr1:197115467G>C	uc001gtu.2	-	1	358	c.101C>G	c.(100-102)TCT>TGT	p.S34C	ASPM_uc001gtv.2_Missense_Mutation_p.S34C|ASPM_uc001gtw.3_5'UTR	NM_018136	NP_060606	Q8IZT6	ASPM_HUMAN	asp (abnormal spindle)-like, microcephaly	34					mitosis	cytoplasm|nucleus	calmodulin binding			ovary(4)|central_nervous_system(2)	6						CGGCGGGGAagacgcctcctc	0.308			NA											4	107					0	0	0.009096	0	0
NR5A2	2494	broad.mit.edu	37	1	200017620	200017621	+	Missense_Mutation	DNP	GG	GG	TT			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr1:200017620_200017621GG>TT	uc001gvb.2	+	5	990_991	c.784_785GG>TT	c.(784-786)GGC>TTC	p.G262F	NR5A2_uc001gvc.2_Missense_Mutation_p.G216F|NR5A2_uc009wzh.2_Missense_Mutation_p.G222F|NR5A2_uc010pph.1_Missense_Mutation_p.G190F	NM_205860	NP_995582	O00482	NR5A2_HUMAN	nuclear receptor subfamily 5, group A, member 2	262					embryo development|positive regulation of viral genome replication|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	cytoplasm|nucleoplasm	lipid binding|protein binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|steroid hormone receptor activity|transcription regulatory region DNA binding|zinc ion binding			large_intestine(1)|ovary(1)	2	Prostate(682;0.19)					CCAAACATATGGCCACTTTCCT	0.51	Melanoma(179;1138 2773 15678 26136)		NA											9	72					0	0	0.004672	0	0
CAMSAP1L1	23271	broad.mit.edu	37	1	200730088	200730088	+	Silent	SNP	C	C	G			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr1:200730088C>G	uc001gvl.2	+	2	531	c.261C>G	c.(259-261)CTC>CTG	p.L87L	CAMSAP1L1_uc001gvk.2_Silent_p.L87L|CAMSAP1L1_uc001gvm.2_Silent_p.L87L	NM_203459	NP_982284	Q08AD1	CAMP2_HUMAN	calmodulin regulated spectrin-associated protein	87						cytoplasm|microtubule	protein binding			ovary(2)|large_intestine(1)|pancreas(1)	4						CTGGGAGTCTCATTCTCAAGA	0.433			NA											13	93					0	0	0.001855	0	0
LAD1	3898	broad.mit.edu	37	1	201356047	201356047	+	Missense_Mutation	SNP	G	G	C			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr1:201356047G>C	uc001gwm.2	-	3	677	c.442C>G	c.(442-444)CGG>GGG	p.R148G	LAD1_uc009wzu.1_Missense_Mutation_p.R170G	NM_005558	NP_005549	O00515	LAD1_HUMAN	ladinin 1	148						basement membrane	structural molecule activity				0						CGCTGTTCCCGACTCAGTCTC	0.612			NA											12	139					0	0	0.013537	0	0
PRELP	5549	broad.mit.edu	37	1	203455883	203455883	+	Silent	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr1:203455883C>T	uc001gzs.2	+	3	1223	c.1023C>T	c.(1021-1023)GAC>GAT	p.D341D	PRELP_uc001gzt.2_Silent_p.D341D	NM_002725	NP_002716	P51888	PRELP_HUMAN	proline arginine-rich end leucine-rich repeat	341	LRR 11.				skeletal system development	proteinaceous extracellular matrix	extracellular matrix structural constituent			ovary(1)|central_nervous_system(1)|pancreas(1)	3			BRCA - Breast invasive adenocarcinoma(75;0.109)			CGTTCCATGACTTCTCCTCGG	0.562			NA											14	35					0	0	0.00245	0	0
GOLT1A	127845	broad.mit.edu	37	1	204183019	204183019	+	Missense_Mutation	SNP	C	C	G			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr1:204183019C>G	uc001has.1	-	1	202	c.16G>C	c.(16-18)GAA>CAA	p.E6Q	GOLT1A_uc001hat.1_Missense_Mutation_p.E6Q	NM_198447	NP_940849	Q6ZVE7	GOT1A_HUMAN	golgi transport 1 homolog A	6	Cytoplasmic (Potential).				protein transport|vesicle-mediated transport	Golgi membrane|integral to membrane					0	all_cancers(21;0.0165)|Breast(84;0.179)|all_epithelial(62;0.242)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|BRCA - Breast invasive adenocarcinoma(75;0.0833)|Kidney(21;0.0934)|Epithelial(59;0.244)			CTCTGCCATTCGGTGATGGAG	0.642			NA											6	24					0	0	0.001168	0	0
NUCKS1	64710	broad.mit.edu	37	1	205696877	205696877	+	Nonsense_Mutation	SNP	G	G	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr1:205696877G>A	uc001hdb.2	-	3	384	c.124C>T	c.(124-126)CGA>TGA	p.R42*		NM_022731	NP_073568	Q9H1E3	NUCKS_HUMAN	nuclear casein kinase and cyclin-dependent	42						nucleus					0	Breast(84;0.07)		BRCA - Breast invasive adenocarcinoma(75;0.0194)			TTAGCTTCTCGGGGAGATGAT	0.378			NA											7	41					0	0	0.001984	0	0
PLXNA2	5362	broad.mit.edu	37	1	208390760	208390760	+	Missense_Mutation	SNP	C	C	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr1:208390760C>A	uc001hgz.2	-	2	1266	c.508G>T	c.(508-510)GGG>TGG	p.G170W	PLXNA2_uc001hha.3_Missense_Mutation_p.G224W	NM_025179	NP_079455	O75051	PLXA2_HUMAN	plexin A2 precursor	170	Extracellular (Potential).|Sema.				axon guidance	integral to membrane|intracellular|plasma membrane				ovary(2)|central_nervous_system(1)	3				OV - Ovarian serous cystadenocarcinoma(81;0.199)		ACAATCACCCCGTACATGGTG	0.587			NA											38	289					1.56738e-10	1.93688e-10	0.004289	1	0
FAM71A	149647	broad.mit.edu	37	1	212798989	212798989	+	Missense_Mutation	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr1:212798989C>T	uc001hjk.2	+	1	1174	c.770C>T	c.(769-771)GCA>GTA	p.A257V	uc010pth.1_RNA	NM_153606	NP_705834	Q8IYT1	FA71A_HUMAN	hypothetical protein LOC149647	257										skin(3)|ovary(1)|central_nervous_system(1)	5				OV - Ovarian serous cystadenocarcinoma(81;0.00631)|all cancers(67;0.00981)|GBM - Glioblastoma multiforme(131;0.0715)|Epithelial(68;0.094)		GTGCTCAATGCATCCATCCCC	0.413			NA											17	173					0	0	0.007413	0	0
PTPN14	5784	broad.mit.edu	37	1	214551349	214551349	+	Missense_Mutation	SNP	G	G	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr1:214551349G>A	uc001hkk.1	-	14	2912	c.2641C>T	c.(2641-2643)CGG>TGG	p.R881W	PTPN14_uc010pty.1_Missense_Mutation_p.R782W	NM_005401	NP_005392	Q15678	PTN14_HUMAN	protein tyrosine phosphatase, non-receptor type	881					lymphangiogenesis	cytoplasm|cytoskeleton	protein tyrosine phosphatase activity|receptor tyrosine kinase binding			breast(2)|ovary(1)|kidney(1)|skin(1)	5				OV - Ovarian serous cystadenocarcinoma(81;0.00181)|all cancers(67;0.00194)|Epithelial(68;0.0157)|GBM - Glioblastoma multiforme(131;0.155)		TTCTCTTCCCGCCCTGAGACT	0.547	Colon(92;557 1424 24372 34121 40073)		NA											31	47					0	0	0.009535	0	0
PTPN14	5784	broad.mit.edu	37	1	214557780	214557780	+	Missense_Mutation	SNP	T	T	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr1:214557780T>A	uc001hkk.1	-	13	1689	c.1418A>T	c.(1417-1419)AAC>ATC	p.N473I	PTPN14_uc010pty.1_Missense_Mutation_p.N374I	NM_005401	NP_005392	Q15678	PTN14_HUMAN	protein tyrosine phosphatase, non-receptor type	473					lymphangiogenesis	cytoplasm|cytoskeleton	protein tyrosine phosphatase activity|receptor tyrosine kinase binding			breast(2)|ovary(1)|kidney(1)|skin(1)	5				OV - Ovarian serous cystadenocarcinoma(81;0.00181)|all cancers(67;0.00194)|Epithelial(68;0.0157)|GBM - Glioblastoma multiforme(131;0.155)		GGCATGGGTGTTGATAATGTT	0.562	Colon(92;557 1424 24372 34121 40073)		NA											138	143					0	0	0.01441	0	0
USH2A	7399	broad.mit.edu	37	1	216348824	216348824	+	Missense_Mutation	SNP	G	G	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr1:216348824G>A	uc001hku.1	-	21	4784	c.4397C>T	c.(4396-4398)GCA>GTA	p.A1466V	USH2A_uc001hkv.2_Missense_Mutation_p.A1466V	NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	1466	Extracellular (Potential).				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		TTGTGCTGGTGCTAAATATTA	0.373			NA								HNSCC(13;0.011)			12	30					0	0	0.001855	0	0
MARK1	4139	broad.mit.edu	37	1	220825366	220825366	+	Missense_Mutation	SNP	G	G	C			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr1:220825366G>C	uc001hmn.3	+	15	2207	c.1610G>C	c.(1609-1611)GGC>GCC	p.G537A	MARK1_uc009xdw.2_Missense_Mutation_p.G537A|MARK1_uc010pun.1_Missense_Mutation_p.G537A|MARK1_uc001hmm.3_Missense_Mutation_p.G515A	NM_018650	NP_061120	Q9P0L2	MARK1_HUMAN	MAP/microtubule affinity-regulating kinase 1	537					intracellular protein kinase cascade	cytoplasm|microtubule cytoskeleton	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			ovary(4)|central_nervous_system(2)|skin(2)|stomach(1)|lung(1)	10				GBM - Glioblastoma multiforme(131;0.0407)		TCTTCTGCAGGCTCTTCTGTG	0.463			NA											13	78					0	0	0.001855	0	0
DEGS1	8560	broad.mit.edu	37	1	224377623	224377623	+	Missense_Mutation	SNP	G	G	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr1:224377623G>A	uc001hoj.2	+	2	538	c.427G>A	c.(427-429)GAT>AAT	p.D143N	DEGS1_uc001hoi.2_Missense_Mutation_p.D122N	NM_144780	NP_659004	O15121	DEGS1_HUMAN	degenerative spermatocyte homolog 1, lipid	143					sphingolipid metabolic process|unsaturated fatty acid biosynthetic process	endoplasmic reticulum membrane|integral to plasma membrane|membrane fraction	electron carrier activity|protein binding|sphingolipid delta-4 desaturase activity				0	Breast(184;0.193)			GBM - Glioblastoma multiforme(131;0.00643)		CGTCGATGTAGATATTCCTAC	0.408			NA											17	96					0	0	0.00499	0	0
CNIH3	149111	broad.mit.edu	37	1	224872505	224872505	+	Missense_Mutation	SNP	G	G	C			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr1:224872505G>C	uc001hos.1	+	3	856	c.158G>C	c.(157-159)CGG>CCG	p.R53P		NM_152495	NP_689708	Q8TBE1	CNIH3_HUMAN	cornichon homolog 3	53	Lumenal (Potential).				intracellular signal transduction|regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|dendritic shaft|postsynaptic membrane					0	Breast(184;0.218)			GBM - Glioblastoma multiforme(131;0.073)		TAGAGGGAACGGTTGAGGAAC	0.542			NA											6	84					0	0	0.001984	0	0
ACBD3	64746	broad.mit.edu	37	1	226340111	226340111	+	Missense_Mutation	SNP	C	C	G			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr1:226340111C>G	uc001hpy.2	-	7	1347	c.1300G>C	c.(1300-1302)GAA>CAA	p.E434Q		NM_022735	NP_073572	Q9H3P7	GCP60_HUMAN	acyl-Coenzyme A binding domain containing 3	434	GOLD.				steroid biosynthetic process|transport	Golgi membrane|integral to membrane|mitochondrion	fatty-acyl-CoA binding|protein binding				0	Breast(184;0.158)			GBM - Glioblastoma multiforme(131;0.121)		TCTGTCCATTCAAAATACACC	0.468			NA											5	140					0	0	0.000602	0	0
WNT9A	7483	broad.mit.edu	37	1	228109549	228109549	+	Silent	SNP	G	G	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr1:228109549G>A	uc001hri.2	-	4	856	c.768C>T	c.(766-768)ACC>ACT	p.T256T		NM_003395	NP_003386	O14904	WNT9A_HUMAN	wingless-type MMTV integration site family,	256					anterior/posterior pattern formation|axis specification|canonical Wnt receptor signaling pathway|cell-cell signaling|cellular response to retinoic acid|cornea development in camera-type eye|embryonic arm morphogenesis|embryonic skeletal joint morphogenesis|endoderm development|iris morphogenesis|mitotic cell cycle G1/S transition checkpoint|negative regulation of cell proliferation|negative regulation of chondrocyte differentiation|neuron differentiation|positive regulation of smoothened signaling pathway|Wnt receptor signaling pathway, calcium modulating pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	extracellular matrix structural constituent|G-protein-coupled receptor binding|signal transducer activity			central_nervous_system(1)|pancreas(1)	2		Prostate(94;0.0405)				CTTCATTGGTGGTGCTGCCCA	0.672			NA											14	99					0	0	0.00245	0	0
C1orf69	200205	broad.mit.edu	37	1	228363178	228363178	+	Silent	SNP	A	A	G			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr1:228363178A>G	uc001hsl.3	+	3	1124	c.1035A>G	c.(1033-1035)GCA>GCG	p.A345A	C1orf69_uc010pvw.1_Silent_p.A152A	NM_001010867	NP_001010867	Q5T440	CAF17_HUMAN	hypothetical protein LOC200205 precursor	345					glycine catabolic process|heme biosynthetic process	mitochondrion	aminomethyltransferase activity				0		Prostate(94;0.0405)				CCTTAGCCGCATCTGTGCCAG	0.647			NA											73	95					0	0	0.01441	0	0
OBSCN	84033	broad.mit.edu	37	1	228559464	228559464	+	Missense_Mutation	SNP	C	C	G			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr1:228559464C>G	uc009xez.1	+	94	21029	c.20985C>G	c.(20983-20985)ATC>ATG	p.I6995M	OBSCN_uc001hsr.1_Missense_Mutation_p.I1624M	NM_001098623	NP_001092093	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and	6995	Pro-rich.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			stomach(8)|large_intestine(7)|breast(5)|ovary(4)|skin(2)|central_nervous_system(1)|pancreas(1)	28		Prostate(94;0.0405)				GGGCCCCTATCAGGGACATGG	0.692			NA											28	28					0	0	0.009535	0	0
CAPN9	10753	broad.mit.edu	37	1	230910379	230910379	+	Splice_Site	SNP	T	T	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr1:230910379T>A	uc001htz.1	+	8	1066	c.953_splice	c.e8+2	p.W318_splice	CAPN9_uc009xfg.1_Splice_Site_p.W255_splice|CAPN9_uc001hua.1_Intron	NM_006615	NP_006606	O14815	CAN9_HUMAN	calpain 9 isoform 1						digestion|proteolysis	intracellular	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity			ovary(1)	1	Breast(184;0.0871)|Ovarian(103;0.183)	Prostate(94;0.167)				GGAATTCTGGTACCGTGCTTG	0.502			NA											8	41					0	0	0.00308	0	0
TARBP1	6894	broad.mit.edu	37	1	234593467	234593467	+	Silent	SNP	G	G	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr1:234593467G>A	uc001hwd.2	-	9	1668	c.1668C>T	c.(1666-1668)CTC>CTT	p.L556L		NM_005646	NP_005637	Q13395	TARB1_HUMAN	TAR RNA binding protein 1	556					regulation of transcription from RNA polymerase II promoter|RNA processing	nucleus	RNA binding|RNA methyltransferase activity			ovary(2)|skin(1)	3	Ovarian(103;0.0339)	all_cancers(173;0.00995)|Prostate(94;0.0115)|all_epithelial(177;0.172)	OV - Ovarian serous cystadenocarcinoma(106;0.000263)			TCAGAGACATGAGAAAAGTTG	0.328			NA											18	15					0	0	0.012319	0	0
TBCE	6905	broad.mit.edu	37	1	235612020	235612020	+	Silent	SNP	A	A	C			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr1:235612020A>C	uc001hwz.1	+	17	1650	c.1527A>C	c.(1525-1527)CTA>CTC	p.L509L	TBCE_uc001hxa.1_Silent_p.L509L|TBCE_uc010pxr.1_Silent_p.L560L|TBCE_uc001hxb.1_Silent_p.L396L|B3GALNT2_uc001hxc.2_3'UTR	NM_003193	NP_003184	Q15813	TBCE_HUMAN	beta-tubulin cofactor E	509					'de novo' posttranslational protein folding|post-chaperonin tubulin folding pathway	cytoplasm|microtubule|nucleus|plasma membrane	chaperone binding				0	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.00192)|Prostate(94;0.0294)|all_epithelial(177;0.155)|Lung SC(1967;0.238)	OV - Ovarian serous cystadenocarcinoma(106;2.56e-05)			AAAATGACCTAAAGTCATTAC	0.393			NA											9	54					0	0	0.006214	0	0
ACTN2	88	broad.mit.edu	37	1	236918345	236918345	+	Silent	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr1:236918345C>T	uc001hyf.2	+	17	2205	c.2001C>T	c.(1999-2001)ATC>ATT	p.I667I	ACTN2_uc001hyg.2_Silent_p.I459I|ACTN2_uc009xgi.1_Silent_p.I667I|ACTN2_uc010pxu.1_Silent_p.I356I|ACTN2_uc001hyh.2_Silent_p.I355I	NM_001103	NP_001094	P35609	ACTN2_HUMAN	actinin, alpha 2	667	Spectrin 4.				focal adhesion assembly|microspike assembly|muscle filament sliding|platelet activation|platelet degranulation|protein homotetramerization|regulation of apoptosis|synaptic transmission	actin filament|cytosol|dendritic spine|extracellular region|filopodium|focal adhesion|nucleolus|platelet alpha granule lumen|pseudopodium|Z disc	actin binding|calcium ion binding|FATZ 1 binding|identical protein binding|integrin binding|protein dimerization activity|structural constituent of muscle|titin binding|titin Z domain binding|ZASP binding			ovary(4)|skin(1)	5	Ovarian(103;0.0634)|Breast(184;0.221)	all_cancers(173;0.00661)|Acute lymphoblastic leukemia(190;0.109)|Prostate(94;0.174)	OV - Ovarian serous cystadenocarcinoma(106;0.00168)			CCATCCAGATCACAGGAGCCC	0.557			NA											28	130					0	0	0.007291	0	0
RYR2	6262	broad.mit.edu	37	1	237753224	237753224	+	Missense_Mutation	SNP	A	A	G			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr1:237753224A>G	uc001hyl.1	+	30	3850	c.3730A>G	c.(3730-3732)AAC>GAC	p.N1244D		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	1244	Cytoplasmic (By similarity).|4 X approximate repeats.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			CGTTAATACAAACAGGGATAT	0.398			NA											17	25					0	0	0.00499	0	0
ZP4	57829	broad.mit.edu	37	1	238050702	238050702	+	Missense_Mutation	SNP	G	G	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr1:238050702G>A	uc001hym.2	-	5	713	c.713C>T	c.(712-714)CCA>CTA	p.P238L	LOC100130331_uc010pyc.1_Intron	NM_021186	NP_067009	Q12836	ZP4_HUMAN	zona pellucida glycoprotein 4 preproprotein	238	ZP.|Extracellular (Potential).				acrosomal vesicle exocytosis|negative regulation of binding of sperm to zona pellucida|positive regulation of acrosome reaction|positive regulation of humoral immune response|positive regulation of protein kinase activity|positive regulation of T cell proliferation|protein kinase A signaling cascade|protein kinase C signaling cascade	integral to membrane|intracellular|plasma membrane|proteinaceous extracellular matrix	acrosin binding|receptor activity			ovary(2)|skin(1)	3	Ovarian(103;0.103)	all_cancers(173;0.00175)|all_epithelial(177;0.162)|all_neural(198;0.164)|Melanoma(53;0.211)|Prostate(94;0.214)	OV - Ovarian serous cystadenocarcinoma(106;0.00989)			GGAAGTAAATGGAAACTGGAA	0.522	NSCLC(166;160 2029 11600 18754 19936)		NA											15	94					0	0	0.006122	0	0
C1orf101	257044	broad.mit.edu	37	1	244716037	244716037	+	Missense_Mutation	SNP	G	G	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr1:244716037G>A	uc001iam.2	+	9	1009	c.950G>A	c.(949-951)GGA>GAA	p.G317E	C1orf101_uc001iak.1_Intron|C1orf101_uc001ial.2_Missense_Mutation_p.G317E|C1orf101_uc010pym.1_Missense_Mutation_p.G166E|C1orf101_uc010pyn.1_Missense_Mutation_p.G250E	NM_001130957	NP_001124429	Q5SY80	CA101_HUMAN	hypothetical protein LOC257044 isoform 1	317	Extracellular (Potential).					integral to membrane				ovary(1)|breast(1)	2	all_cancers(71;2.99e-05)|all_epithelial(71;0.00015)|all_neural(11;0.0269)|Breast(184;0.0654)|Glioma(6;0.0724)|Ovarian(71;0.0761)|all_lung(81;0.0874)|Lung NSC(105;0.121)		all cancers(7;1.22e-05)|OV - Ovarian serous cystadenocarcinoma(106;0.001)|GBM - Glioblastoma multiforme(7;0.0154)			ATAAGACTGGGAGGAATTGTA	0.343			NA											43	41					0	0	0.011902	0	0
AHCTF1	25909	broad.mit.edu	37	1	247065962	247065962	+	Missense_Mutation	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr1:247065962C>T	uc001ibu.1	-	7	989	c.982G>A	c.(982-984)GAA>AAA	p.E328K	AHCTF1_uc001ibv.1_Missense_Mutation_p.E337K	NM_015446	NP_056261	Q8WYP5	ELYS_HUMAN	transcription factor ELYS	328	Necessary for cytoplasmic localization (By similarity).				cytokinesis|mitotic prometaphase|mRNA transport|nuclear pore complex assembly|protein transport|transmembrane transport	condensed chromosome kinetochore|cytosol|nuclear matrix|nuclear membrane|nuclear pore|nucleoplasm	DNA binding			ovary(5)|skin(2)	7	all_cancers(71;3.05e-05)|all_epithelial(71;6.72e-06)|Ovarian(71;0.0173)|Breast(184;0.0318)|all_lung(81;0.0458)|Lung NSC(105;0.0518)	all_cancers(173;0.0266)	OV - Ovarian serous cystadenocarcinoma(106;0.00271)			TATCTTTCTTCACAGTATTCT	0.368	Colon(145;197 1800 4745 15099 26333)		NA											16	71					0	0	0.00499	0	0
OR2W5	441932	broad.mit.edu	37	1	247654775	247654775	+	Missense_Mutation	SNP	G	G	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr1:247654775G>A	uc001icz.1	+	1	346	c.346G>A	c.(346-348)GTT>ATT	p.V116I		NM_001004698	NP_001004698	A6NFC9	OR2W5_HUMAN	olfactory receptor, family 2, subfamily W,	116	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|breast(1)|skin(1)	3	all_cancers(71;4.51e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.222)	OV - Ovarian serous cystadenocarcinoma(106;0.0188)			CGTCCTCCTGGTTGTCATGTC	0.607			NA											55	82					0	0	0.01441	0	0
OR2C3	81472	broad.mit.edu	37	1	247695646	247695646	+	Silent	SNP	G	G	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr1:247695646G>T	uc009xgy.2	-	2	530	c.168C>A	c.(166-168)CTC>CTA	p.L56L	C1orf150_uc009xgw.2_Intron|C1orf150_uc001ida.3_Intron|C1orf150_uc001idb.3_Intron|C1orf150_uc009xgx.2_Intron|LOC148824_uc001idd.2_5'Flank	NM_198074	NP_932340	Q8N628	OR2C3_HUMAN	olfactory receptor, family 2, subfamily C,	56	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	all_cancers(71;4.51e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.0242)	OV - Ovarian serous cystadenocarcinoma(106;0.0241)			TAGGTGTGTGGAGGTGCACAT	0.493			NA											46	52					1.76056e-25	2.42306e-25	0.011902	1	0
OR13G1	441933	broad.mit.edu	37	1	247835786	247835786	+	Silent	SNP	A	A	G			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr1:247835786A>G	uc001idi.1	-	1	558	c.558T>C	c.(556-558)TGT>TGC	p.C186C		NM_001005487	NP_001005487	Q8NGZ3	O13G1_HUMAN	olfactory receptor, family 13, subfamily G,	186	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.017)			TTACAGGGCTACAGGACAAAG	0.463			NA											6	52					0	0	0.001984	0	0
OR13G1	441933	broad.mit.edu	37	1	247836167	247836167	+	Missense_Mutation	SNP	G	G	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr1:247836167G>T	uc001idi.1	-	1	177	c.177C>A	c.(175-177)TTC>TTA	p.F59L		NM_001005487	NP_001005487	Q8NGZ3	O13G1_HUMAN	olfactory receptor, family 13, subfamily G,	59	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.017)			GTGTCAGAAGGAAAACATACA	0.418			NA											14	10					1.05317e-09	1.28397e-09	0.00245	1	0
OR6F1	343169	broad.mit.edu	37	1	247875710	247875710	+	Silent	SNP	T	T	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr1:247875710T>A	uc001idj.1	-	1	348	c.348A>T	c.(346-348)GCA>GCT	p.A116A		NM_001005286	NP_001005286	Q8NGZ6	OR6F1_HUMAN	olfactory receptor, family 6, subfamily F,	116	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.0168)			AAGCCATGGCTGCCAGGAGGA	0.517			NA											7	47					0	0	0.001984	0	0
OR2W3	343171	broad.mit.edu	37	1	248059305	248059305	+	Missense_Mutation	SNP	G	G	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr1:248059305G>T	uc001idp.1	+	3	686	c.417G>T	c.(415-417)AGG>AGT	p.R139S	OR2W3_uc010pzb.1_Missense_Mutation_p.R139S	NM_001001957	NP_001001957	Q7Z3T1	OR2W3_HUMAN	olfactory receptor, family 2, subfamily W,	139	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|breast(1)|pancreas(1)	3	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0319)			TGAACCCCAGGCTCTGCCGGG	0.627			NA											47	44					1.7489e-18	2.34263e-18	0.011902	1	0
OR2M2	391194	broad.mit.edu	37	1	248343411	248343411	+	Missense_Mutation	SNP	A	A	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr1:248343411A>T	uc010pzf.1	+	1	124	c.124A>T	c.(124-126)AAC>TAC	p.N42Y		NM_001004688	NP_001004688	Q96R28	OR2M2_HUMAN	olfactory receptor, family 2, subfamily M,	42	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(3)|skin(1)	4	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			CTTCATGGGAAACTCTGTCAT	0.522			NA											115	124					0	0	0.01441	0	0
OR2T6	254879	broad.mit.edu	37	1	248551236	248551236	+	Silent	SNP	G	G	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr1:248551236G>T	uc001iei.1	+	1	327	c.327G>T	c.(325-327)GGG>GGT	p.G109G		NM_001005471	NP_001005471	Q8NHC8	OR2T6_HUMAN	olfactory receptor, family 2, subfamily T,	109	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			GCTTTATGGGGGCTGAATTCT	0.562			NA											15	76					0.000308642	0.000328795	0.003163	1	0
OR2T34	127068	broad.mit.edu	37	1	248737412	248737412	+	Missense_Mutation	SNP	A	A	G			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr1:248737412A>G	uc001iep.1	-	1	647	c.647T>C	c.(646-648)ATC>ACC	p.I216T		NM_001001821	NP_001001821	Q8NGX1	O2T34_HUMAN	olfactory receptor, family 2, subfamily T,	216	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(1)|ovary(1)	2	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			GATGACCATGATGGGGGTGAG	0.572			NA											28	100					0	0	0.007291	0	0
OR2T27	403239	broad.mit.edu	37	1	248813783	248813783	+	Missense_Mutation	SNP	G	G	C			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr1:248813783G>C	uc010pzo.1	-	1	403	c.403C>G	c.(403-405)CTC>GTC	p.L135V		NM_001001824	NP_001001824	Q8NH04	O2T27_HUMAN	olfactory receptor, family 2, subfamily T,	135	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	all_cancers(71;1.15e-05)|all_epithelial(71;5.29e-06)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.089)|Lung NSC(105;0.0969)|Melanoma(84;0.199)	all_cancers(173;0.237)	OV - Ovarian serous cystadenocarcinoma(106;0.0265)			CGGCTCATGAGGACAGGATAG	0.552			NA											23	15					0	0	0.008361	0	0
ZNF692	55657	broad.mit.edu	37	1	249144947	249144947	+	Missense_Mutation	SNP	C	C	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr1:249144947C>A	uc001ifc.1	-	11	1354	c.1187G>T	c.(1186-1188)CGG>CTG	p.R396L	ZNF692_uc001iez.1_Missense_Mutation_p.R118L|ZNF692_uc001ifa.1_Missense_Mutation_p.R118L|ZNF692_uc001ifb.1_Missense_Mutation_p.R192L|ZNF692_uc001ifd.1_Missense_Mutation_p.R395L|ZNF692_uc001ife.1_RNA|ZNF692_uc001iff.1_Missense_Mutation_p.R351L|ZNF692_uc010pzr.1_Missense_Mutation_p.R401L	NM_017865	NP_060335	Q9BU19	ZN692_HUMAN	zinc finger protein 692 isoform 2	396	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_cancers(71;3.33e-06)|all_epithelial(71;2.41e-06)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.0458)|Lung NSC(105;0.0494)|Melanoma(84;0.199)	all_cancers(173;0.19)	OV - Ovarian serous cystadenocarcinoma(106;0.00805)			GCGGAAAGACCGGGCGCAGAA	0.622			NA											15	59					2.31682e-05	2.54658e-05	0.003163	1	0
PGBD2	267002	broad.mit.edu	37	1	249210873	249210873	+	Missense_Mutation	SNP	G	G	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr1:249210873G>T	uc001ifh.2	+	3	237	c.90G>T	c.(88-90)ATG>ATT	p.M30I	PGBD2_uc001ifg.2_Intron|PGBD2_uc009xhd.2_Missense_Mutation_p.M27I	NM_170725	NP_733843	Q6P3X8	PGBD2_HUMAN	hypothetical protein LOC267002 isoform a	30										ovary(1)	1	all_cancers(71;3.33e-06)|all_epithelial(71;2.41e-06)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.0458)|Lung NSC(105;0.0494)|Melanoma(84;0.199)	all_cancers(173;0.012)	OV - Ovarian serous cystadenocarcinoma(106;0.00989)			TGAATGCTATGGAGGAGGAAG	0.478			NA											8	42					0.00448238	0.00463893	0.004482	1	0
KLF6	1316	broad.mit.edu	37	10	3822343	3822343	+	Missense_Mutation	SNP	C	C	G			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr10:3822343C>G	uc001iha.2	-	3	1022	c.755G>C	c.(754-756)CGA>CCA	p.R252P	KLF6_uc010qaj.1_Intron|KLF6_uc010qak.1_RNA|KLF6_uc010qal.1_Missense_Mutation_p.R210P	NM_001300	NP_001291	Q99612	KLF6_HUMAN	Kruppel-like factor 6 isoform A	252	C2H2-type 2.				B cell differentiation	nucleus	zinc ion binding			central_nervous_system(3)|lung(1)	4				Colorectal(1;0.238)		GGTGTGCTTTCGGAAGTGCCT	0.542			NA											7	26					0	0	0.001984	0	0
USP6NL	9712	broad.mit.edu	37	10	11505373	11505373	+	Silent	SNP	G	G	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr10:11505373G>T	uc001ikt.3	-	15	1875	c.1554C>A	c.(1552-1554)ACC>ACA	p.T518T	USP6NL_uc001iks.1_Silent_p.T535T	NM_014688	NP_055503	Q92738	US6NL_HUMAN	USP6 N-terminal like isoform 1	518						intracellular	Rab GTPase activator activity				0						GACCTGGGACGGTAACTGCGA	0.597			NA											69	76					6.26901e-30	8.7357e-30	0.01441	1	0
FRMD4A	55691	broad.mit.edu	37	10	13702486	13702486	+	Silent	SNP	T	T	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr10:13702486T>A	uc001ims.2	-	20	2080	c.1728A>T	c.(1726-1728)CCA>CCT	p.P576P	FRMD4A_uc009xjf.1_Silent_p.P576P	NM_018027	NP_060497	Q9P2Q2	FRM4A_HUMAN	FERM domain containing 4A	576						cytoplasm|cytoskeleton	binding			ovary(1)|skin(1)|pancreas(1)	3						TGTGCGACGGTGGCCGAGGAG	0.562			NA									OREG0020030	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	38	44					0	0	0.003755	0	0
FAM107B	83641	broad.mit.edu	37	10	14563219	14563219	+	Silent	SNP	G	G	C			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr10:14563219G>C	uc001imx.1	-	4	611	c.366C>G	c.(364-366)GGC>GGG	p.G122G	FAM107B_uc001ina.1_Silent_p.G297G|FAM107B_uc010qbu.1_RNA|FAM107B_uc009xjg.1_Silent_p.G122G|FAM107B_uc001imy.1_Silent_p.G122G|FAM107B_uc001imz.1_Silent_p.G122G	NM_031453	NP_113641	Q9H098	F107B_HUMAN	hypothetical protein LOC83641	122										breast(4)	4						CGACTTCTTGGCCTGTTCTCC	0.517			NA											51	79					0	0	0.01441	0	0
SUV39H2	79723	broad.mit.edu	37	10	14939210	14939210	+	Silent	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr10:14939210C>T	uc001inh.2	+	2	419	c.363C>T	c.(361-363)ATC>ATT	p.I121I	SUV39H2_uc001ing.2_Intron|SUV39H2_uc001ini.2_Silent_p.I121I|SUV39H2_uc001inj.2_Silent_p.I121I	NM_024670	NP_078946	Q9H5I1	SUV92_HUMAN	suppressor of variegation 3-9 homolog 2	181					cell cycle|cell differentiation|chromatin assembly or disassembly|chromatin remodeling|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromatin|chromosome, centromeric region|nucleus	histone methyltransferase activity (H3-K9 specific)|protein binding|zinc ion binding			breast(2)|ovary(1)	3						CTCCTGGAATCAGCTTAGTCA	0.363			NA											13	58					0	0	0.013537	0	0
OLAH	55301	broad.mit.edu	37	10	15103747	15103747	+	Missense_Mutation	SNP	G	G	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr10:15103747G>T	uc001inu.2	+	4	442	c.188G>T	c.(187-189)AGA>ATA	p.R63I	ACBD7_uc010qby.1_Intron|OLAH_uc001int.2_Missense_Mutation_p.R116I	NM_001039702	NP_001034791	Q9NV23	SAST_HUMAN	oleoyl-ACP hydrolase isoform 2	63					fatty acid biosynthetic process		myristoyl-[acyl-carrier-protein] hydrolase activity|oleoyl-[acyl-carrier-protein] hydrolase activity|palmitoyl-[acyl-carrier-protein] hydrolase activity				0						CTTCCTGGAAGAGAAAGCAGA	0.423			NA											17	23					2.23348e-06	2.53163e-06	0.004007	1	0
C10orf111	221060	broad.mit.edu	37	10	15138469	15138469	+	Missense_Mutation	SNP	G	G	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr10:15138469G>A	uc001inw.2	-	2	629	c.355C>T	c.(355-357)CTT>TTT	p.L119F	RPP38_uc001iny.3_5'Flank|RPP38_uc009xjm.2_5'Flank|RPP38_uc001inx.3_5'Flank	NM_153244	NP_694976	Q8N326	CJ111_HUMAN	hypothetical protein LOC221060	119	Helical; (Potential).					integral to membrane					0						GCGGGGAGAAGGAGGAGGCTC	0.478			NA											26	30					0	0	0.003954	0	0
NMT2	9397	broad.mit.edu	37	10	15210517	15210517	+	Missense_Mutation	SNP	G	G	C			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr10:15210517G>C	uc001inz.1	-	1	179	c.95C>G	c.(94-96)ACG>AGG	p.T32R	NMT2_uc001ioa.1_Missense_Mutation_p.R5G|NMT2_uc009xjo.1_Missense_Mutation_p.T32R	NM_004808	NP_004799	O60551	NMT2_HUMAN	N-myristoyltransferase 2	32					N-terminal protein myristoylation|protein lipoylation	Golgi apparatus|plasma membrane	glycylpeptide N-tetradecanoyltransferase activity			ovary(1)	1						GGCGTGCTCCGTCTCCTCCTC	0.726	Melanoma(117;1345 1645 4130 12688 30625)		NA											9	68					0	0	0.008291	0	0
ITGA8	8516	broad.mit.edu	37	10	15760843	15760843	+	Missense_Mutation	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr10:15760843C>T	uc001ioc.1	-	2	265	c.265G>A	c.(265-267)GAA>AAA	p.E89K	ITGA8_uc010qcb.1_Missense_Mutation_p.E89K	NM_003638	NP_003629	P53708	ITA8_HUMAN	integrin, alpha 8 precursor	89	Extracellular (Potential).|FG-GAP 1.				cell differentiation|cell-cell adhesion|cell-matrix adhesion|integrin-mediated signaling pathway|nervous system development	integrin complex	receptor activity			ovary(3)|lung(3)	6						GCTCCCCCTTCCACGATATCG	0.567			NA											21	102					0	0	0.014323	0	0
ST8SIA6	338596	broad.mit.edu	37	10	17495561	17495561	+	Missense_Mutation	SNP	T	T	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr10:17495561T>A	uc001ipd.2	-	2	197	c.197A>T	c.(196-198)AAC>ATC	p.N66I	ST8SIA6_uc010qce.1_RNA	NM_001004470	NP_001004470	P61647	SIA8F_HUMAN	ST8 alpha-N-acetyl-neuraminide	66	Lumenal (Potential).				post-translational protein modification|protein N-linked glycosylation via asparagine	integral to Golgi membrane	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity			ovary(1)	1						GCTGTACCTGTTAGTGGCGCG	0.731			NA											3	11					0	0	0.004672	0	0
GPR158	57512	broad.mit.edu	37	10	25861687	25861687	+	Missense_Mutation	SNP	A	A	C			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr10:25861687A>C	uc001isj.2	+	7	1684	c.1624A>C	c.(1624-1626)ATT>CTT	p.I542L		NM_020752	NP_065803	Q5T848	GP158_HUMAN	G protein-coupled receptor 158 precursor	542	Helical; Name=4; (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(4)|large_intestine(2)|pancreas(1)|skin(1)	8						TTGGTTTCTCATTGGCTGGAC	0.453			NA											14	29					0	0	0.00245	0	0
GPR158	57512	broad.mit.edu	37	10	25887236	25887236	+	Missense_Mutation	SNP	C	C	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr10:25887236C>A	uc001isj.2	+	11	2741	c.2681C>A	c.(2680-2682)CCA>CAA	p.P894Q	GPR158_uc001isk.2_Missense_Mutation_p.P269Q	NM_020752	NP_065803	Q5T848	GP158_HUMAN	G protein-coupled receptor 158 precursor	894	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(4)|large_intestine(2)|pancreas(1)|skin(1)	8						ACTGGGCACCCACGAACATCG	0.517			NA											21	88					4.96729e-08	5.87338e-08	0.008871	1	0
LYZL2	119180	broad.mit.edu	37	10	30918542	30918542	+	Silent	SNP	G	G	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr10:30918542G>T	uc001ivk.2	-	1	106	c.93C>A	c.(91-93)GGC>GGA	p.G31G		NM_183058	NP_898881	Q7Z4W2	LYZL2_HUMAN	lysozyme-like 2	Error:Variant_position_missing_in_Q7Z4W2_after_alignment					cell wall macromolecule catabolic process	extracellular region	lysozyme activity				0		Prostate(175;0.151)				GATTCCTGGTGCCTGCCGCAG	0.517			NA											11	32					3.86212e-05	4.21639e-05	0.008291	1	0
Unknown	0	broad.mit.edu	37	10	30998254	30998254	+	Missense_Mutation	SNP	G	G	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr10:30998254G>T	uc010qdx.1	+	8	1342	c.800G>T	c.(799-801)CGC>CTC	p.R267L						SubName: Full=cDNA FLJ59642, highly similar to Supervillin;												NA						TTCGCGCCCCGCCTGTTCGTC	0.507			NA											8	20					7.48243e-07	8.60894e-07	0.006214	1	0
ARHGAP12	94134	broad.mit.edu	37	10	32103262	32103262	+	Nonsense_Mutation	SNP	C	C	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr10:32103262C>A	uc001ivz.1	-	14	2029	c.1759G>T	c.(1759-1761)GAG>TAG	p.E587*	ARHGAP12_uc001ivy.1_Nonsense_Mutation_p.E533*|ARHGAP12_uc009xls.2_Nonsense_Mutation_p.E538*|ARHGAP12_uc001iwb.1_Nonsense_Mutation_p.E580*|ARHGAP12_uc001iwc.1_Nonsense_Mutation_p.E555*|ARHGAP12_uc009xlq.1_Nonsense_Mutation_p.E508*|ARHGAP12_uc001iwd.1_Nonsense_Mutation_p.E555*|ARHGAP12_uc009xlr.1_Nonsense_Mutation_p.E585*	NM_018287	NP_060757	Q8IWW6	RHG12_HUMAN	Rho GTPase activating protein 12	587					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity				0		Prostate(175;0.0199)				GGTATCTCCTCTTCAATTCCT	0.363			NA											29	68					5.60225e-13	7.14804e-13	0.009535	1	0
ZNF248	57209	broad.mit.edu	37	10	38126615	38126615	+	Silent	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr10:38126615C>T	uc001izd.1	-	5	667	c.168G>A	c.(166-168)GTG>GTA	p.V56V	ZNF248_uc009xmc.2_Silent_p.V56V|ZNF248_uc001izb.2_RNA|ZNF248_uc001izc.2_Silent_p.V56V|ZNF248_uc010qeu.1_Silent_p.V56V	NM_021045	NP_066383	Q8NDW4	ZN248_HUMAN	zinc finger protein 248	56	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						TCTTAAAGATCACTTCTGGTT	0.438			NA											5	40					0	0	0.000602	0	0
BMS1	9790	broad.mit.edu	37	10	43292056	43292056	+	Missense_Mutation	SNP	G	G	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr10:43292056G>T	uc001jaj.2	+	10	1722	c.1364G>T	c.(1363-1365)GGG>GTG	p.G455V		NM_014753	NP_055568	Q14692	BMS1_HUMAN	BMS1-like, ribosome assembly protein	455					ribosome assembly	nucleolus	ATP binding|GTP binding|GTPase activity			ovary(2)|upper_aerodigestive_tract(1)	3						GAAGATGACGGGTTGGAAAAC	0.438			NA											7	31					0.00198382	0.00206488	0.001984	1	0
GDF2	2658	broad.mit.edu	37	10	48414052	48414052	+	Silent	SNP	C	C	G			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr10:48414052C>G	uc001jfa.1	-	2	979	c.816G>C	c.(814-816)CTG>CTC	p.L272L		NM_016204	NP_057288	Q9UK05	GDF2_HUMAN	growth differentiation factor 2 precursor	272					activin receptor signaling pathway|BMP signaling pathway|cartilage development|cellular iron ion homeostasis|growth|negative regulation of angiogenesis|negative regulation of blood vessel endothelial cell migration|negative regulation of cell growth|negative regulation of DNA replication|negative regulation of endothelial cell proliferation|ossification|pathway-restricted SMAD protein phosphorylation|patterning of blood vessels|positive regulation of angiogenesis|positive regulation of endothelial cell proliferation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of transcription, DNA-dependent	extracellular space	cytokine activity|growth factor activity			ovary(2)|skin(1)	3						TCATCTCCCTCAGCTCCAGCC	0.572			NA											9	63					0	0	0.004482	0	0
GDF10	2662	broad.mit.edu	37	10	48428803	48428803	+	Silent	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr10:48428803C>T	uc001jfb.2	-	2	1539	c.1083G>A	c.(1081-1083)ACG>ACA	p.T361T	GDF10_uc009xnp.2_Silent_p.T360T|GDF10_uc009xnq.1_Silent_p.T361T	NM_004962	NP_004953	P55107	BMP3B_HUMAN	growth differentiation factor 10 precursor	361					growth|skeletal system development|transforming growth factor beta receptor signaling pathway	extracellular space	cytokine activity|growth factor activity			lung(1)|central_nervous_system(1)	2						CTTTCTGCATCGTCTTCTCGT	0.612			NA											14	50					0	0	0.003163	0	0
ERCC6	2074	broad.mit.edu	37	10	50679084	50679084	+	Missense_Mutation	SNP	C	C	G			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr10:50679084C>G	uc001jhs.3	-	17	3161	c.3007G>C	c.(3007-3009)GAG>CAG	p.E1003Q	ERCC6_uc009xod.2_Missense_Mutation_p.E163Q|ERCC6_uc010qgr.1_Missense_Mutation_p.E373Q|ERCC6_uc001jhr.3_Missense_Mutation_p.E371Q	NM_000124	NP_000115	Q03468	ERCC6_HUMAN	excision repair cross-complementing rodent	1003					base-excision repair|positive regulation of transcription elongation, DNA-dependent|transcription from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair	nucleolus|soluble fraction|transcription elongation factor complex	ATP binding|chromatin binding|DNA binding|DNA-dependent ATPase activity|helicase activity|protein C-terminus binding|protein complex binding|protein N-terminus binding			lung(5)|breast(5)|ovary(3)|large_intestine(2)|skin(1)	16						GTAAATAGCTCATAGAGATCA	0.313			NA						Direct_reversal_of_damage|NER					11	68					0	0	0.010729	0	0
BICC1	80114	broad.mit.edu	37	10	60566883	60566883	+	Missense_Mutation	SNP	G	G	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr10:60566883G>T	uc001jki.1	+	17	2341	c.2341G>T	c.(2341-2343)GTG>TTG	p.V781L	BICC1_uc001jkj.1_Missense_Mutation_p.V422L	NM_001080512	NP_001073981	Q9H694	BICC1_HUMAN	bicaudal C homolog 1	781					multicellular organismal development		RNA binding			ovary(2)|lung(1)|skin(1)	4						GGCCAATCATGTGTCCTATAA	0.468			NA											32	66					4.74835e-14	6.15041e-14	0.010818	1	0
FAM13C	220965	broad.mit.edu	37	10	61028318	61028318	+	Missense_Mutation	SNP	A	A	G			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr10:61028318A>G	uc001jkn.2	-	9	1071	c.937T>C	c.(937-939)TAC>CAC	p.Y313H	FAM13C_uc001jko.2_Missense_Mutation_p.Y313H|FAM13C_uc010qid.1_Missense_Mutation_p.Y230H|FAM13C_uc010qie.1_Missense_Mutation_p.Y230H|FAM13C_uc010qif.1_Missense_Mutation_p.Y335H|FAM13C_uc001jkp.2_Missense_Mutation_p.Y230H	NM_198215	NP_937858	Q8NE31	FA13C_HUMAN	hypothetical protein LOC220965 isoform 1	313										ovary(2)	2						CTTACCCGGTATTTCTTTTCT	0.493			NA											18	31					0	0	0.007413	0	0
CCDC6	8030	broad.mit.edu	37	10	61554281	61554281	+	Missense_Mutation	SNP	T	T	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr10:61554281T>A	uc001jks.3	-	8	1816	c.1180A>T	c.(1180-1182)AAT>TAT	p.N394Y		NM_005436	NP_005427	Q16204	CCDC6_HUMAN	coiled-coil domain containing 6	394						cytoplasm|cytoskeleton	SH3 domain binding|structural constituent of cytoskeleton			ovary(3)|breast(1)	4				Kidney(211;0.0597)		CCCGGGGAATTGTAATAAGAC	0.448			NA											24	32					0	0	0.00278	0	0
REEP3	221035	broad.mit.edu	37	10	65357812	65357812	+	Missense_Mutation	SNP	G	G	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr10:65357812G>A	uc001jmt.2	+	4	394	c.211G>A	c.(211-213)GCT>ACT	p.A71T	REEP3_uc009xpl.1_Missense_Mutation_p.A71T	NM_001001330	NP_001001330	Q6NUK4	REEP3_HUMAN	receptor accessory protein 3	71	Helical; (Potential).					integral to membrane					0	Prostate(12;0.0119)|all_hematologic(501;0.191)					GCTGAAGATTGCTTTTGTCAT	0.348			NA											17	39					0	0	0.007413	0	0
CTNNA3	29119	broad.mit.edu	37	10	67829219	67829219	+	Missense_Mutation	SNP	T	T	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr10:67829219T>A	uc009xpn.1	-	15	2129	c.2006A>T	c.(2005-2007)GAA>GTA	p.E669V	CTNNA3_uc001jmw.2_Missense_Mutation_p.E669V	NM_001127384	NP_001120856	Q9UI47	CTNA3_HUMAN	catenin, alpha 3	669					cell-cell adhesion	actin cytoskeleton|cytoplasm|fascia adherens	cadherin binding|structural molecule activity			skin(3)|ovary(2)|pancreas(1)|lung(1)|central_nervous_system(1)	8						CTTTTCTTTTTCTGCCTCAGG	0.348			NA											9	32					0	0	0.004482	0	0
SIRT1	23411	broad.mit.edu	37	10	69651262	69651262	+	Missense_Mutation	SNP	G	G	C			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr10:69651262G>C	uc001jnd.2	+	4	945	c.892G>C	c.(892-894)GAT>CAT	p.D298H	SIRT1_uc010qis.1_Missense_Mutation_p.D3H|SIRT1_uc009xpp.2_Missense_Mutation_p.D106H|SIRT1_uc001jne.2_5'UTR	NM_012238	NP_036370	Q96EB6	SIRT1_HUMAN	sirtuin 1 isoform a	298	Deacetylase sirtuin-type.				apoptosis|cell aging|cellular response to hydrogen peroxide|cellular response to starvation|chromatin silencing at rDNA|DNA repair|DNA replication|establishment of chromatin silencing|histone H3 deacetylation|interspecies interaction between organisms|maintenance of chromatin silencing|muscle organ development|negative regulation of androgen receptor signaling pathway|negative regulation of cell growth|negative regulation of DNA damage response, signal transduction by p53 class mediator|negative regulation of fat cell differentiation|negative regulation of helicase activity|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|peptidyl-lysine acetylation|peptidyl-lysine deacetylation|positive regulation of anti-apoptosis|positive regulation of chromatin silencing|positive regulation of DNA repair|regulation of apoptosis|regulation of cell proliferation|regulation of endodeoxyribonuclease activity|regulation of protein import into nucleus, translocation|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|rRNA processing|transcription, DNA-dependent|triglyceride mobilization|white fat cell differentiation	chromatin silencing complex|cytoplasm|nuclear euchromatin|nuclear heterochromatin|nuclear inner membrane|nucleolus|PML body|rDNA heterochromatin	bHLH transcription factor binding|histone binding|HLH domain binding|identical protein binding|mitogen-activated protein kinase binding|NAD+ binding|NAD-dependent histone deacetylase activity (H3-K9 specific)|p53 binding|protein C-terminus binding|transcription corepressor activity|zinc ion binding				0						AGCGATGTTTGATATTGAATA	0.403			NA											24	133					0	0	0.00333	0	0
TET1	80312	broad.mit.edu	37	10	70406705	70406705	+	Missense_Mutation	SNP	A	A	G			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr10:70406705A>G	uc001jok.3	+	4	4724	c.4219A>G	c.(4219-4221)ACA>GCA	p.T1407A		NM_030625	NP_085128	Q8NFU7	TET1_HUMAN	CXXC finger 6	1407					DNA demethylation|inner cell mass cell differentiation|negative regulation of methylation-dependent chromatin silencing|stem cell maintenance		iron ion binding|methylcytosine dioxygenase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|structure-specific DNA binding|zinc ion binding			ovary(5)|lung(2)|prostate(1)|breast(1)	9						TACTAACCCTACAAAAAACCT	0.388			NA											9	36					0	0	0.006214	0	0
DDX50	79009	broad.mit.edu	37	10	70706206	70706206	+	Silent	SNP	G	G	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr10:70706206G>A	uc001jou.2	+	15	2141	c.2034G>A	c.(2032-2034)CAG>CAA	p.Q678Q	DDX50_uc010qjc.1_Intron	NM_024045	NP_076950	Q9BQ39	DDX50_HUMAN	nucleolar protein GU2	678	Arg-rich.					nucleolus	ATP binding|ATP-dependent helicase activity|RNA binding			ovary(1)	1						ATTCCAGACAGAGGAGTGGCT	0.522			NA											3	45					0	0	0.001984	0	0
HK1	3098	broad.mit.edu	37	10	71048521	71048521	+	Missense_Mutation	SNP	G	G	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr10:71048521G>A	uc001jpj.3	+	4	416	c.22G>A	c.(22-24)GAA>AAA	p.E8K	HK1_uc009xqc.1_Missense_Mutation_p.E8K|HK1_uc001jpg.3_5'UTR|HK1_uc001jph.3_Missense_Mutation_p.E8K|HK1_uc001jpi.3_Missense_Mutation_p.E8K	NM_033500	NP_277035	P19367	HXK1_HUMAN	hexokinase 1 isoform HKI-td	Error:Variant_position_missing_in_P19367_after_alignment					glucose transport|glycolysis|transmembrane transport	cytosol|mitochondrial outer membrane|nucleus	ATP binding|glucokinase activity			ovary(1)	1						CTGCCAGCGAGAATCGGTAAG	0.348			NA											4	35					0	0	0.000602	0	0
NEUROG3	50674	broad.mit.edu	37	10	71332433	71332433	+	Missense_Mutation	SNP	C	C	G	rs140128333		TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr10:71332433C>G	uc001jpp.2	-	2	525	c.367G>C	c.(367-369)GAG>CAG	p.E123Q		NM_020999	NP_066279	Q9Y4Z2	NGN3_HUMAN	neurogenin 3	123	Helix-loop-helix motif.				central nervous system development|endocrine pancreas development|peripheral nervous system development|positive regulation of sequence-specific DNA binding transcription factor activity	nucleus	transcription coactivator activity				0						CGCAGCGTCTCGATCTTGGTG	0.652			NA											5	42					0	0	0.000602	0	0
KIAA1274	27143	broad.mit.edu	37	10	72292391	72292391	+	Silent	SNP	C	C	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr10:72292391C>A	uc001jrd.3	+	6	929	c.648C>A	c.(646-648)GCC>GCA	p.A216A		NM_014431	NP_055246	Q9ULE6	PALD_HUMAN	KIAA1274	216										ovary(2)|central_nervous_system(1)	3						ACGACTTTGCCCAGCTGAGCG	0.587			NA											22	118					1.50039e-11	1.88132e-11	0.012319	1	0
C10orf27	219793	broad.mit.edu	37	10	72541683	72541683	+	Silent	SNP	G	G	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr10:72541683G>T	uc001jrj.1	-	4	541	c.151C>A	c.(151-153)CGG>AGG	p.R51R	C10orf27_uc010qjm.1_Silent_p.R51R|C10orf27_uc009xqh.1_RNA|C10orf27_uc010qjn.1_Silent_p.R51R|C10orf27_uc009xqi.1_RNA|C10orf27_uc010qjo.1_Silent_p.R40R|C10orf27_uc009xqj.1_Silent_p.R40R|C10orf27_uc010qjp.1_Silent_p.R40R	NM_152710	NP_689923	Q96M53	SPATL_HUMAN	stromal protein associated with thymii and lymph	51					cell differentiation|multicellular organismal development|spermatogenesis	cytosol				skin(1)	1						CGGCGGATCCGCTCGAAATCC	0.597			NA											41	100					6.2361e-21	8.43093e-21	0.007835	1	0
OIT3	170392	broad.mit.edu	37	10	74660219	74660219	+	Missense_Mutation	SNP	G	G	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr10:74660219G>T	uc001jte.1	+	3	739	c.521G>T	c.(520-522)GGC>GTC	p.G174V	OIT3_uc009xqs.1_RNA	NM_152635	NP_689848	Q8WWZ8	OIT3_HUMAN	oncoprotein-induced transcript 3 precursor	174						nuclear envelope	calcium ion binding			ovary(2)	2	Prostate(51;0.0198)					ACTGTGCTAGGCCCTGACAGG	0.473	Colon(7;19 345 13446 17537)		NA											5	28					3.59834e-05	3.94026e-05	0.001168	1	0
TTC18	118491	broad.mit.edu	37	10	75095212	75095212	+	Missense_Mutation	SNP	T	T	C			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr10:75095212T>C	uc009xrc.2	-	8	984	c.863A>G	c.(862-864)TAC>TGC	p.Y288C	TTC18_uc001jty.2_Missense_Mutation_p.Y288C|TTC18_uc009xrd.1_Missense_Mutation_p.Y96C	NM_145170	NP_660153	Q5T0N1	TTC18_HUMAN	tetratricopeptide repeat domain 18	288							binding			ovary(2)|central_nervous_system(1)	3	Prostate(51;0.0119)					AGGATCAAGGTAGCAGCGACT	0.393			NA											7	21					0	0	0.001984	0	0
NDST2	8509	broad.mit.edu	37	10	75565368	75565368	+	Missense_Mutation	SNP	G	G	C			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr10:75565368G>C	uc001jvk.2	-	8	2527	c.1723C>G	c.(1723-1725)CAG>GAG	p.Q575E	NDST2_uc010qks.1_Missense_Mutation_p.Q201E|NDST2_uc010qkt.1_Missense_Mutation_p.Q452E|NDST2_uc001jvl.1_5'Flank|NDST2_uc009xro.2_Missense_Mutation_p.Q201E|NDST2_uc010qku.1_Missense_Mutation_p.Q450E	NM_003635	NP_003626	P52849	NDST2_HUMAN	heparan glucosaminyl	575	Lumenal (Potential).|Heparan sulfate N-deacetylase 2.					Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine N-sulfotransferase activity|hydrolase activity			ovary(1)	1	Prostate(51;0.0112)					CTTCGCTCCTGAGGGAAAAGT	0.473			NA											6	41					0	0	0.001168	0	0
KCNMA1	3778	broad.mit.edu	37	10	78651442	78651442	+	Silent	SNP	C	C	G			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr10:78651442C>G	uc001jxn.2	-	26	3360	c.3183G>C	c.(3181-3183)CGG>CGC	p.R1061R	KCNMA1_uc001jxj.2_Silent_p.R1007R|KCNMA1_uc001jxk.1_Silent_p.R679R|KCNMA1_uc009xrt.1_Silent_p.R852R|KCNMA1_uc001jxl.1_Silent_p.R686R|KCNMA1_uc001jxo.2_Silent_p.R1044R|KCNMA1_uc001jxm.2_Silent_p.R1003R|KCNMA1_uc001jxq.2_Silent_p.R1033R|uc001jxp.2_Intron	NM_001161352	NP_001154824	Q12791	KCMA1_HUMAN	large conductance calcium-activated potassium	1061	Cytoplasmic (Potential).				cellular potassium ion homeostasis|negative regulation of cell volume|platelet activation|positive regulation of apoptosis|regulation of membrane potential|response to calcium ion|response to carbon monoxide|response to hypoxia|response to osmotic stress|smooth muscle contraction involved in micturition	apical plasma membrane|caveola|integral to membrane|voltage-gated potassium channel complex	actin binding|calcium-activated potassium channel activity|large conductance calcium-activated potassium channel activity|metal ion binding|voltage-gated potassium channel activity			pancreas(2)|ovary(1)	3	all_cancers(46;0.203)|all_epithelial(25;0.00604)|Prostate(51;0.0198)		OV - Ovarian serous cystadenocarcinoma(4;0.0586)|Epithelial(14;0.081)|all cancers(16;0.183)		Bendroflumethiazide(DB00436)|Benzthiazide(DB00562)|Chlorothiazide(DB00880)|Chlorzoxazone(DB00356)|Cromoglicate(DB01003)|Cyclothiazide(DB00606)|Diazoxide(DB01119)|Enflurane(DB00228)|Hydrochlorothiazide(DB00999)|Hydroflumethiazide(DB00774)|Methyclothiazide(DB00232)|Quinethazone(DB01325)|Trichlormethiazide(DB01021)	TCACCAGGGTCCGTATCAGGG	0.542			NA											14	40					0	0	0.00245	0	0
LDB3	11155	broad.mit.edu	37	10	88476445	88476445	+	Silent	SNP	T	T	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr10:88476445T>A	uc001kdv.2	+	9	1616	c.1593T>A	c.(1591-1593)CTT>CTA	p.L531L	LDB3_uc010qml.1_Silent_p.L468L|LDB3_uc010qmm.1_Silent_p.L536L|LDB3_uc001kdu.2_Silent_p.L421L|LDB3_uc009xsz.2_Silent_p.L160L|LDB3_uc009xta.1_5'Flank	NM_007078	NP_009009	O75112	LDB3_HUMAN	LIM domain binding 3 isoform 1	531						cytoskeleton|perinuclear region of cytoplasm|pseudopodium	zinc ion binding			ovary(1)	1						TGCCACCACTTGCCAGGGGGA	0.652			NA											10	50					0	0	0.006214	0	0
CYP26C1	340665	broad.mit.edu	37	10	94828349	94828349	+	Silent	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr10:94828349C>T	uc010qns.1	+	6	1464	c.1464C>T	c.(1462-1464)GCC>GCT	p.A488A	CYP26C1_uc009xud.2_RNA	NM_183374	NP_899230	Q6V0L0	CP26C_HUMAN	cytochrome P450, family 26, subfamily C,	488					anterior/posterior pattern formation|central nervous system development|negative regulation of retinoic acid receptor signaling pathway|neural crest cell development|organelle fusion|retinoic acid catabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	electron carrier activity|heme binding|retinoic acid 4-hydroxylase activity|retinoic acid binding			central_nervous_system(1)	1		Colorectal(252;0.122)				CCACACCCGCCTTCCCCGCCA	0.692			NA											5	7					0	0	0.000602	0	0
CYP2C18	1562	broad.mit.edu	37	10	96447589	96447589	+	Missense_Mutation	SNP	G	G	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr10:96447589G>T	uc001kjv.3	+	2	557	c.231G>T	c.(229-231)TTG>TTT	p.L77F	CYP2C18_uc001kjw.3_Missense_Mutation_p.L77F|CYP2C19_uc009xus.1_5'Flank|CYP2C19_uc010qny.1_5'Flank	NM_000772	NP_000763	P33260	CP2CI_HUMAN	cytochrome P450 family 2 subfamily C polypeptide	77					xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding			ovary(3)|lung(1)|skin(1)	5		Colorectal(252;0.09)		all cancers(201;2.8e-06)|KIRC - Kidney renal clear cell carcinoma(50;0.0646)|Kidney(138;0.0805)		TTGTGGTGTTGCATGGATATG	0.423			NA											40	77					1.49673e-21	2.03108e-21	0.00623	1	0
CYP2C18	1562	broad.mit.edu	37	10	96454680	96454680	+	Missense_Mutation	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr10:96454680C>T	uc001kjv.3	+	4	814	c.488C>T	c.(487-489)CCC>CTC	p.P163L	CYP2C18_uc001kjw.3_Missense_Mutation_p.P163L|CYP2C19_uc009xus.1_Intron|CYP2C19_uc010qny.1_5'UTR	NM_000772	NP_000763	P33260	CP2CI_HUMAN	cytochrome P450 family 2 subfamily C polypeptide	163					xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding			ovary(3)|lung(1)|skin(1)	5		Colorectal(252;0.09)		all cancers(201;2.8e-06)|KIRC - Kidney renal clear cell carcinoma(50;0.0646)|Kidney(138;0.0805)		TTAGCCTCACCCTGTGATCCC	0.328			NA											21	34					0	0	0.003954	0	0
ENTPD1	953	broad.mit.edu	37	10	97605318	97605318	+	Nonsense_Mutation	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr10:97605318C>T	uc001klh.3	+	6	1102	c.778C>T	c.(778-780)CAG>TAG	p.Q260*	ENTPD1_uc001kle.1_Nonsense_Mutation_p.Q267*|ENTPD1_uc001kli.3_Nonsense_Mutation_p.Q267*|uc001klg.1_Intron|ENTPD1_uc010qoj.1_Nonsense_Mutation_p.Q272*|ENTPD1_uc010qok.1_Nonsense_Mutation_p.Q152*|ENTPD1_uc010qol.1_Nonsense_Mutation_p.Q152*|ENTPD1_uc010qom.1_Nonsense_Mutation_p.Q260*|ENTPD1_uc010qon.1_Nonsense_Mutation_p.Q122*|ENTPD1_uc009xva.2_Nonsense_Mutation_p.Q122*|ENTPD1_uc009xuz.2_RNA	NM_001776	NP_001767	P49961	ENTP1_HUMAN	ectonucleoside triphosphate diphosphohydrolase 1	260	Extracellular (Potential).				cell adhesion	integral to plasma membrane	ATP binding			ovary(3)	3		Colorectal(252;0.0821)		Epithelial(162;1.31e-07)|all cancers(201;5.33e-06)		TGGGAAGGATCAGGCACTCTG	0.502			NA											17	73					0	0	0.004007	0	0
SLIT1	6585	broad.mit.edu	37	10	98807550	98807550	+	Missense_Mutation	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr10:98807550C>T	uc001kmw.2	-	16	1783	c.1531G>A	c.(1531-1533)GTG>ATG	p.V511M	SLIT1_uc009xvh.1_Missense_Mutation_p.V521M	NM_003061	NP_003052	O75093	SLIT1_HUMAN	slit homolog 1 precursor	511	LRRNT 3.				axon extension involved in axon guidance|forebrain morphogenesis|motor axon guidance|negative chemotaxis|negative regulation of synaptogenesis	cytoplasm|extracellular space	calcium ion binding|Roundabout binding			ovary(4)	4		Colorectal(252;0.162)		Epithelial(162;2.02e-08)|all cancers(201;1.5e-06)		GGACAGACCACGTCGCTGTTG	0.647			NA											32	57					0	0	0.008361	0	0
BLOC1S2	282991	broad.mit.edu	37	10	102039910	102039910	+	Missense_Mutation	SNP	T	T	C			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr10:102039910T>C	uc001kqw.1	-	4	391	c.368A>G	c.(367-369)TAC>TGC	p.Y123C	BLOC1S2_uc001kqv.1_Missense_Mutation_p.Y80C	NM_173809	NP_776170	Q6QNY1	BL1S2_HUMAN	biogenesis of lysosome-related organelles	123	Potential.				melanosome organization|microtubule nucleation|platelet dense granule organization|positive regulation of cell proliferation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|regulation of apoptosis	BLOC-1 complex|centrosome|gamma-tubulin complex|nucleus	gamma-tubulin binding|identical protein binding|protein C-terminus binding			ovary(1)	1		Colorectal(252;0.117)		Epithelial(162;2.44e-10)|all cancers(201;1.97e-08)		ATCCAACTTGTAAGCTGCCTG	0.368			NA											8	49					0	0	0.004482	0	0
LZTS2	84445	broad.mit.edu	37	10	102763856	102763856	+	Missense_Mutation	SNP	G	G	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr10:102763856G>A	uc001ksj.2	+	3	1070	c.1001G>A	c.(1000-1002)CGA>CAA	p.R334Q	LZTS2_uc010qpw.1_Missense_Mutation_p.R334Q|LZTS2_uc001ksk.2_Missense_Mutation_p.R334Q|LZTS2_uc001ksl.2_Missense_Mutation_p.R334Q|LZTS2_uc001ksm.2_RNA	NM_032429	NP_115805	Q9BRK4	LZTS2_HUMAN	leucine zipper, putative tumor suppressor 2	334	Potential.				cell division|mitosis|Wnt receptor signaling pathway	membrane|microtubule|microtubule organizing center				ovary(2)|large_intestine(1)|breast(1)	4				Epithelial(162;7.3e-09)|all cancers(201;3.72e-07)		GGAAAGCTCCGAGACCGGGAG	0.632	Esophageal Squamous(8;38 437 13604 19902 37640)		NA											16	69					0	0	0.00499	0	0
LDB1	8861	broad.mit.edu	37	10	103870845	103870845	+	Missense_Mutation	SNP	C	C	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr10:103870845C>A	uc009xwz.2	-	4	573	c.230G>T	c.(229-231)CGG>CTG	p.R77L	LDB1_uc001kuk.3_Missense_Mutation_p.R41L|LDB1_uc001kul.3_Missense_Mutation_p.R41L	NM_001113407	NP_001106878	Q86U70	LDB1_HUMAN	LIM domain binding 1 isoform 1	77					histone H3-K4 acetylation|negative regulation of erythrocyte differentiation|negative regulation of transcription, DNA-dependent|positive regulation of hemoglobin biosynthetic process|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription elongation, DNA-dependent|transcription, DNA-dependent|transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery	nuclear chromatin|protein complex	LIM domain binding|protein homodimerization activity|transcription corepressor activity			large_intestine(1)	1		Colorectal(252;0.122)		Epithelial(162;1.11e-07)|all cancers(201;1.82e-06)		GTTCTGAAGCCGTTTGTTAAG	0.532			NA											12	40					2.80697e-09	3.40495e-09	0.010729	1	0
ADRA2A	150	broad.mit.edu	37	10	112838147	112838147	+	Missense_Mutation	SNP	C	C	G			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr10:112838147C>G	uc001kzo.2	+	1	1358	c.393C>G	c.(391-393)TTC>TTG	p.F131L		NM_000681	NP_000672	P08913	ADA2A_HUMAN	alpha-2A-adrenergic receptor	116	Helical; Name=3; (By similarity).				actin cytoskeleton organization|activation of MAPK activity by adrenergic receptor signaling pathway|activation of phospholipase C activity by adrenergic receptor signaling pathway|activation of protein kinase B activity|blood coagulation|cellular component movement|cellular response to hormone stimulus|energy reserve metabolic process|epidermal growth factor receptor transactivation by G-protein coupled receptor signaling pathway|glucose homeostasis|inhibition of adenylate cyclase activity by adrenergic receptor signaling pathway|intestinal absorption|negative regulation of adrenergic receptor signaling pathway|negative regulation of calcium ion transport via voltage-gated calcium channel activity|negative regulation of cAMP biosynthetic process|negative regulation of epinephrine secretion|negative regulation of insulin secretion involved in cellular response to glucose stimulus|negative regulation of lipid catabolic process|negative regulation of norepinephrine secretion|positive regulation of cell migration|positive regulation of cell proliferation|positive regulation of cytokine production|positive regulation of membrane protein ectodomain proteolysis|positive regulation of potassium ion transport|positive regulation of wound healing|Rho protein signal transduction	basolateral plasma membrane|cytoplasm|integral to plasma membrane|receptor complex	alpha-1B adrenergic receptor binding|alpha-2C adrenergic receptor binding|alpha2-adrenergic receptor activity|epinephrine binding|heterotrimeric G-protein binding|norepinephrine binding|protein heterodimerization activity|protein homodimerization activity|protein kinase binding|thioesterase binding				0		Breast(234;0.0735)|Lung NSC(174;0.238)		Epithelial(162;0.000316)|all cancers(201;0.00501)|BRCA - Breast invasive adenocarcinoma(275;0.118)	Amitriptyline(DB00321)|Amphetamine(DB00182)|Apraclonidine(DB00964)|Benzphetamine(DB00865)|Bethanidine(DB00217)|Brimonidine(DB00484)|Clonidine(DB00575)|Debrisoquin(DB04840)|Dexmedetomidine(DB00633)|Dipivefrin(DB00449)|Epinastine(DB00751)|Ergotamine(DB00696)|Fenoldopam(DB00800)|Guanabenz(DB00629)|Guanadrel Sulfate(DB00226)|Guanethidine(DB01170)|Guanfacine(DB01018)|Lofexidine(DB04948)|Methyldopa(DB00968)|Mianserin(DB06148)|Mirtazapine(DB00370)|Norepinephrine(DB00368)|Oxymetazoline(DB00935)|Phentolamine(DB00692)|Phenylpropanolamine(DB00397)|Pseudoephedrine(DB00852)|Tizanidine(DB00697)|Trazodone(DB00656)|Yohimbine(DB01392)	ACGTGCTCTTCTGCACGTCGT	0.622	Esophageal Squamous(173;605 2658 7278 49362)		NA											10	33					0	0	0.006214	0	0
C10orf81	79949	broad.mit.edu	37	10	115540407	115540407	+	Missense_Mutation	SNP	A	A	G			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr10:115540407A>G	uc009xyc.1	+	13	1659	c.968A>G	c.(967-969)CAT>CGT	p.H323R	C10orf81_uc001lar.1_3'UTR|C10orf81_uc001las.1_Missense_Mutation_p.H323R|C10orf81_uc001lau.1_Missense_Mutation_p.H239R|C10orf81_uc001lav.2_5'Flank			Q5SXH7	CJ081_HUMAN	RecName: Full=PH domain-containing protein C10orf81;	419										central_nervous_system(1)	1		Colorectal(252;0.175)		Epithelial(162;0.0181)|all cancers(201;0.0204)		GAGACATTCCATGCTGCATCC	0.423			NA											6	32					0	0	0.001168	0	0
ATRNL1	26033	broad.mit.edu	37	10	116925403	116925403	+	Missense_Mutation	SNP	C	C	G			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr10:116925403C>G	uc001lcg.2	+	7	1476	c.1090C>G	c.(1090-1092)CAG>GAG	p.Q364E	ATRNL1_uc001lce.2_RNA|ATRNL1_uc001lcf.2_Missense_Mutation_p.Q364E|ATRNL1_uc009xyq.2_Intron	NM_207303	NP_997186	Q5VV63	ATRN1_HUMAN	attractin-like 1 precursor	364	Extracellular (Potential).|Kelch 1.					integral to membrane	sugar binding			ovary(5)|lung(1)|central_nervous_system(1)	7		all_lung(145;0.0686)|Breast(234;0.0969)|Lung NSC(174;0.17)|Colorectal(252;0.234)		Epithelial(162;0.00031)|all cancers(201;0.000753)|LUSC - Lung squamous cell carcinoma(1;0.0515)|Lung(30;0.0827)		TGCTTTATATCAGGTATGGCT	0.313			NA											3	24					0	0	0.004672	0	0
PDZD8	118987	broad.mit.edu	37	10	119043108	119043108	+	Missense_Mutation	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr10:119043108C>T	uc001lde.1	-	5	3335	c.3136G>A	c.(3136-3138)GAA>AAA	p.E1046K		NM_173791	NP_776152	Q8NEN9	PDZD8_HUMAN	PDZ domain containing 8	1046	Potential.				intracellular signal transduction		metal ion binding				0		Colorectal(252;0.19)		all cancers(201;0.0121)		TGATCAATTTCATTCTGTAGC	0.383			NA											17	63					0	0	0.004007	0	0
PPAPDC1A	196051	broad.mit.edu	37	10	122263423	122263423	+	Silent	SNP	T	T	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr10:122263423T>A	uc001lev.1	+	2	502	c.150T>A	c.(148-150)CCT>CCA	p.P50P	PPAPDC1A_uc010qtd.1_Silent_p.P50P|PPAPDC1A_uc009xzl.1_Silent_p.P50P|PPAPDC1A_uc001lew.1_Silent_p.P50P|PPAPDC1A_uc001lex.1_Silent_p.P50P|PPAPDC1A_uc001ley.1_5'UTR	NM_001030059	NP_001025230	Q5VZY2	PPC1A_HUMAN	phosphatidic acid phosphatase type 2 domain	50	Helical; (Potential).				phospholipid dephosphorylation	integral to membrane	phosphatidate phosphatase activity			breast(1)	1		Lung NSC(174;0.1)|all_lung(145;0.132)		all cancers(201;0.0117)		ATAACATACCTACCCGCCTCA	0.393			NA											15	46					0	0	0.004007	0	0
DMBT1	1755	broad.mit.edu	37	10	124377590	124377590	+	Missense_Mutation	SNP	G	G	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr10:124377590G>T	uc001lgk.1	+	38	4668	c.4562G>T	c.(4561-4563)CGA>CTA	p.R1521L	DMBT1_uc001lgl.1_Missense_Mutation_p.R1511L|DMBT1_uc001lgm.1_Missense_Mutation_p.R893L|DMBT1_uc009xzz.1_Missense_Mutation_p.R1521L|DMBT1_uc010qtx.1_Missense_Mutation_p.R372L|DMBT1_uc009yab.1_Missense_Mutation_p.R224L|DMBT1_uc009yac.1_5'Flank	NM_007329	NP_015568	Q9UGM3	DMBT1_HUMAN	deleted in malignant brain tumors 1 isoform b	1521	SRCR 12.				epithelial cell differentiation|induction of bacterial agglutination|innate immune response|interspecies interaction between organisms|protein transport|response to virus	extrinsic to membrane|phagocytic vesicle membrane|zymogen granule membrane	calcium-dependent protein binding|Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|pattern recognition receptor activity|scavenger receptor activity|zymogen binding			central_nervous_system(7)	7		all_neural(114;0.0765)|Lung NSC(174;0.132)|all_lung(145;0.163)|Breast(234;0.238)				TGTCGAGGCCGAGTGGAGGTC	0.582	Ovarian(182;93 2026 18125 22222 38972)		NA											81	392					1.39159e-27	1.93173e-27	0.01441	1	0
ADAM12	8038	broad.mit.edu	37	10	127782626	127782626	+	Missense_Mutation	SNP	T	T	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr10:127782626T>A	uc001ljk.2	-	11	1495	c.1082A>T	c.(1081-1083)GAC>GTC	p.D361V	ADAM12_uc010qul.1_Missense_Mutation_p.D312V|ADAM12_uc001ljm.2_Missense_Mutation_p.D361V|ADAM12_uc001ljn.2_Missense_Mutation_p.D358V|ADAM12_uc001ljl.3_Missense_Mutation_p.D358V	NM_003474	NP_003465	O43184	ADA12_HUMAN	ADAM metallopeptidase domain 12 isoform 1	361	Extracellular (Potential).|Peptidase M12B.				cell adhesion|epidermal growth factor receptor signaling pathway|myoblast fusion|proteolysis	extracellular region|integral to membrane|plasma membrane	metalloendopeptidase activity|protein binding|SH3 domain binding|zinc ion binding			breast(4)|ovary(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	9		all_epithelial(44;7.06e-05)|all_lung(145;0.00563)|Lung NSC(174;0.00834)|Colorectal(57;0.102)|all_neural(114;0.107)|Breast(234;0.22)		COAD - Colon adenocarcinoma(40;0.141)|Colorectal(40;0.216)		GTCCAGTGTGTCATGATTCAT	0.517			NA											14	74					0	0	0.001855	0	0
MKI67	4288	broad.mit.edu	37	10	129903116	129903116	+	Nonsense_Mutation	SNP	T	T	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr10:129903116T>A	uc001lke.2	-	13	7183	c.6988A>T	c.(6988-6990)AAG>TAG	p.K2330*	MKI67_uc001lkf.2_Nonsense_Mutation_p.K1970*|MKI67_uc009yav.1_Nonsense_Mutation_p.K1905*|MKI67_uc009yaw.1_Nonsense_Mutation_p.K1480*	NM_002417	NP_002408	P46013	KI67_HUMAN	antigen identified by monoclonal antibody Ki-67	2330	16 X 122 AA approximate repeats.				cell proliferation	nucleolus	ATP binding|protein C-terminus binding			ovary(4)|central_nervous_system(2)|skin(1)	7		all_epithelial(44;2.12e-05)|all_lung(145;0.00679)|Lung NSC(174;0.00998)|all_neural(114;0.0936)|Colorectal(57;0.14)|Breast(234;0.166)|Melanoma(40;0.203)				GTCGTGGGCTTGTCAGTGCCT	0.522			NA											119	308					0	0	0.01441	0	0
Unknown	0	broad.mit.edu	37	10	134648922	134648922	+	Missense_Mutation	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr10:134648922C>T	uc010qux.1	-	39	5808	c.5808G>A	c.(5806-5808)ATG>ATA	p.M1936I		NM_017609	NP_060079			Homo sapiens cDNA, FLJ17989.												NA						TGGCCAGACGCATCACCTTGC	0.632			NA											17	51					0	0	0.006122	0	0
FRG2B	441581	broad.mit.edu	37	10	135440237	135440237	+	Missense_Mutation	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr10:135440237C>T	uc010qvg.1	-	1	63	c.10G>A	c.(10-12)GGA>AGA	p.G4R		NM_001080998	NP_001074467	Q96QU4	FRG2B_HUMAN	FSHD region gene 2 family, member B	4						nucleus					0		all_cancers(35;7.01e-07)|all_epithelial(44;1.45e-05)|Lung NSC(174;0.027)|all_lung(145;0.0384)|all_neural(114;0.0726)|Glioma(114;0.172)|Melanoma(40;0.175)		OV - Ovarian serous cystadenocarcinoma(35;1.12e-06)|all cancers(32;1.43e-06)|Epithelial(32;1.71e-06)		TCTTCATTTCCCTTTCCCATG	0.522			NA											7	184					0	0	0.00308	0	0
IFITM1	8519	broad.mit.edu	37	11	315104	315104	+	Silent	SNP	G	G	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr11:315104G>T	uc001loy.3	+	2	549	c.369G>T	c.(367-369)CGG>CGT	p.R123R		NM_003641	NP_003632	P13164	IFM1_HUMAN	interferon induced transmembrane protein 1	123	Interaction with CAV1.|Extracellular (Potential).				negative regulation of cell proliferation|regulation of immune response|response to virus|type I interferon-mediated signaling pathway	integral to membrane|plasma membrane	protein binding|receptor signaling protein activity				0		all_cancers(49;2e-09)|all_epithelial(84;3.36e-06)|Breast(177;0.000162)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.0538)|all_lung(207;0.0713)		all cancers(45;8.85e-28)|Epithelial(43;5.52e-27)|OV - Ovarian serous cystadenocarcinoma(40;1.11e-20)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0327)|LUSC - Lung squamous cell carcinoma(625;0.122)		AGGAAAAACGGGGTTACTAGT	0.527			NA											19	65					3.8784e-16	5.12415e-16	0.012319	1	0
MUC6	4588	broad.mit.edu	37	11	1025314	1025314	+	Silent	SNP	G	G	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr11:1025314G>T	uc001lsw.2	-	23	2904	c.2853C>A	c.(2851-2853)CCC>CCA	p.P951P		NM_005961	NP_005952	Q6W4X9	MUC6_HUMAN	mucin 6, gastric	951	VWFD 3.				maintenance of gastrointestinal epithelium	extracellular region	extracellular matrix structural constituent			ovary(1)	1		all_cancers(49;3.3e-08)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		all cancers(45;1.24e-24)|BRCA - Breast invasive adenocarcinoma(625;0.00031)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)		GCTGCACGTGGGGCTCCTCCC	0.657			NA											31	74					2.2171e-23	3.03415e-23	0.009535	1	0
MUC5B	727897	broad.mit.edu	37	11	1271377	1271377	+	Missense_Mutation	SNP	G	G	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr11:1271377G>A	uc009ycr.1	+	51	14812	c.14686G>A	c.(14686-14688)GAG>AAG	p.E4896K	MUC5B_uc001ltb.2_Missense_Mutation_p.E4426K	NM_017511	NP_059981	Q9HC84	MUC5B_HUMAN	SubName: Full=Mucin 5AC, oligomeric mucus/gel-forming;	4423	23 X approximate tandem repeats, Ser/Thr- rich.|Thr-rich.				cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding				0		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		GATCCTCACAGAGCTGACCAC	0.647			NA											29	113					0	0	0.010818	0	0
BRSK2	9024	broad.mit.edu	37	11	1475797	1475797	+	Silent	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr11:1475797C>T	uc001lti.2	+	16	2013	c.1627C>T	c.(1627-1629)CTG>TTG	p.L543L	BRSK2_uc009ycv.1_Silent_p.L565L|BRSK2_uc001lth.1_Silent_p.L543L|BRSK2_uc001ltj.2_Silent_p.L543L|BRSK2_uc001ltk.2_RNA|BRSK2_uc001ltl.2_Silent_p.L543L|BRSK2_uc001ltm.2_Silent_p.L589L|BRSK2_uc001ltn.2_RNA|BRSK2_uc010qwx.1_RNA|BRSK2_uc009ycw.2_Silent_p.L39L	NM_003957	NP_003948	Q8IWQ3	BRSK2_HUMAN	BR serine/threonine kinase 2	543					establishment of cell polarity|neuron differentiation		ATP binding|magnesium ion binding|protein serine/threonine kinase activity				0		all_epithelial(84;4.17e-05)|Breast(177;0.000307)|Ovarian(85;0.0014)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00144)|Lung(200;0.0713)|LUSC - Lung squamous cell carcinoma(625;0.0842)		AGACAAACCTCTGAGCTCCAT	0.622			NA											10	48					0	0	0.010729	0	0
TNNI2	7136	broad.mit.edu	37	11	1862435	1862435	+	Nonsense_Mutation	SNP	A	A	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr11:1862435A>T	uc010qxe.1	+	5	473	c.451A>T	c.(451-453)AAG>TAG	p.K151*	TNNI2_uc010qxc.1_Nonsense_Mutation_p.K149*|TNNI2_uc010qxd.1_Nonsense_Mutation_p.K149*	NM_001145841	NP_001139313	P48788	TNNI2_HUMAN	fast-twitch skeletal muscle troponin I isoform	151					muscle filament sliding|positive regulation of transcription, DNA-dependent|skeletal muscle contraction	cytosol|nucleus|troponin complex	actin binding|troponin T binding				0		all_epithelial(84;0.000138)|Breast(177;0.000962)|Ovarian(85;0.0014)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00136)|Lung(200;0.0681)|LUSC - Lung squamous cell carcinoma(625;0.082)		GGACACAGAGAAGGTGCGTGC	0.667			NA											8	27					0	0	0.006214	0	0
TH	7054	broad.mit.edu	37	11	2191051	2191051	+	Missense_Mutation	SNP	C	C	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr11:2191051C>A	uc001lvq.2	-	3	253	c.234G>T	c.(232-234)AAG>AAT	p.K78N	TH_uc001lvp.2_Missense_Mutation_p.K74N|TH_uc001lvr.2_Missense_Mutation_p.K47N|TH_uc010qxj.1_Missense_Mutation_p.K51N|TH_uc001lvs.2_Missense_Mutation_p.K47N|TH_uc001lvt.2_Missense_Mutation_p.K51N|TH_uc009ydh.1_5'Flank	NM_199292	NP_954986	P07101	TY3H_HUMAN	tyrosine hydroxylase isoform a	78					dopamine biosynthetic process from tyrosine|embryonic camera-type eye morphogenesis|epinephrine biosynthetic process|eye photoreceptor cell development|heart morphogenesis|hormone biosynthetic process|learning|locomotory behavior|memory|neurotransmitter biosynthetic process|neurotransmitter secretion|norepinephrine biosynthetic process|pigmentation|regulation of heart contraction|response to ethanol|response to hypoxia|synaptic transmission, dopaminergic|visual perception	cytosol|internal side of plasma membrane|melanosome membrane|nucleus|perikaryon|smooth endoplasmic reticulum	protein binding|tyrosine 3-monooxygenase activity				0		all_epithelial(84;1.46e-23)|Lung NSC(207;4.44e-11)|all_lung(207;1.11e-09)|Ovarian(85;1.78e-06)|Breast(177;1.78e-05)|Medulloblastoma(188;0.0208)|all_neural(188;0.0416)	Colorectal(5;0.00245)|COAD - Colon adenocarcinoma(6;0.0239)	BRCA - Breast invasive adenocarcinoma(625;8.45e-09)|Lung(200;0.000152)|LUSC - Lung squamous cell carcinoma(625;0.00154)	L-Phenylalanine(DB00120)|L-Tyrosine(DB00135)|Metyrosine(DB00765)|Tetrahydrobiopterin(DB00360)	CCTCCCGCTCCTTGCGGGCGT	0.721			NA											9	35					7.48243e-07	8.60894e-07	0.006214	1	0
OR51E1	143503	broad.mit.edu	37	11	4674254	4674254	+	Missense_Mutation	SNP	C	C	G			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr11:4674254C>G	uc001lzi.3	+	2	642	c.498C>G	c.(496-498)ATC>ATG	p.I166M		NM_152430	NP_689643	Q8TCB6	O51E1_HUMAN	olfactory receptor, family 51, subfamily E,	165	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(3)|pancreas(1)	4		Medulloblastoma(188;0.0025)|Breast(177;0.0101)|all_neural(188;0.0227)		Epithelial(150;7.37e-14)|GBM - Glioblastoma multiforme(2;2.85e-05)|BRCA - Breast invasive adenocarcinoma(625;0.00222)|LUSC - Lung squamous cell carcinoma(625;0.19)		CTGTCTTCATCAAGCAGCTGC	0.552			NA											26	106					0	0	0.005443	0	0
OR51G2	81282	broad.mit.edu	37	11	4936270	4936270	+	Silent	SNP	G	G	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr11:4936270G>A	uc001lzr.1	-	1	624	c.624C>T	c.(622-624)ATC>ATT	p.I208I		NM_001005238	NP_001005238	Q8NGK0	O51G2_HUMAN	olfactory receptor, family 51, subfamily G,	208	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;5.06e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00438)|LUSC - Lung squamous cell carcinoma(625;0.19)		CTGTAGAGACGATGACAAACA	0.512			NA											9	34					0	0	0.004482	0	0
OR51B6	390058	broad.mit.edu	37	11	5373536	5373536	+	Missense_Mutation	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr11:5373536C>T	uc010qzb.1	+	1	799	c.799C>T	c.(799-801)CCT>TCT	p.P267S	HBG2_uc001mak.1_Intron|HBE1_uc001mam.1_Intron|OR51B5_uc001maq.1_Intron	NM_001004750	NP_001004750	Q9H340	O51B6_HUMAN	olfactory receptor, family 51, subfamily B,	267	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;2.9e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		AAAGCATGTTCCTCATGTCGT	0.408			NA											13	46					0	0	0.001855	0	0
OR52L1	338751	broad.mit.edu	37	11	6007293	6007293	+	Missense_Mutation	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr11:6007293C>T	uc001mcd.2	-	1	923	c.868G>A	c.(868-870)GTC>ATC	p.V290I		NM_001005173	NP_001005173	Q8NGH7	O52L1_HUMAN	olfactory receptor, family 52, subfamily L,	290	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|pancreas(1)	2		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;1.98e-08)|BRCA - Breast invasive adenocarcinoma(625;0.135)		AGAACATGGACATGATGGGGT	0.502	Melanoma(121;653 1666 10547 22796 51255)		NA											5	13					0	0	0.000602	0	0
OR52L1	338751	broad.mit.edu	37	11	6007353	6007353	+	Missense_Mutation	SNP	A	A	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr11:6007353A>T	uc001mcd.2	-	1	863	c.808T>A	c.(808-810)TAT>AAT	p.Y270N		NM_001005173	NP_001005173	Q8NGH7	O52L1_HUMAN	olfactory receptor, family 52, subfamily L,	270	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|pancreas(1)	2		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;1.98e-08)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CCAGGGACATAGAAGACCAGG	0.517	Melanoma(121;653 1666 10547 22796 51255)		NA											11	40					0	0	0.008291	0	0
OR56B4	196335	broad.mit.edu	37	11	6129473	6129473	+	Missense_Mutation	SNP	G	G	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr11:6129473G>T	uc010qzx.1	+	1	465	c.465G>T	c.(463-465)ATG>ATT	p.M155I		NM_001005181	NP_001005181	Q8NH76	O56B4_HUMAN	olfactory receptor, family 56, subfamily B,	155	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;1.31e-08)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GGTTCATCATGCTCAGGAATG	0.502			NA											22	64					1.96292e-10	2.40927e-10	0.010504	1	0
FAM160A2	84067	broad.mit.edu	37	11	6238941	6238941	+	Missense_Mutation	SNP	C	C	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr11:6238941C>A	uc001mcl.3	-	9	2234	c.1875G>T	c.(1873-1875)GAG>GAT	p.E625D	FAM160A2_uc001mck.3_Missense_Mutation_p.E639D|FAM160A2_uc001mcm.2_Missense_Mutation_p.E625D	NM_001098794	NP_001092264	Q8N612	F16A2_HUMAN	hypothetical protein LOC84067 isoform 2	625					early endosome to late endosome transport|endosome organization|endosome to lysosome transport|lysosome organization|protein transport	FHF complex	protein binding			skin(2)	2						GACCAGGGccctcccctgcac	0.378			NA											6	24					0.00116845	0.00122497	0.001168	1	0
DNHD1	144132	broad.mit.edu	37	11	6588332	6588332	+	Missense_Mutation	SNP	A	A	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr11:6588332A>T	uc001mdw.3	+	36	12157	c.11593A>T	c.(11593-11595)AGC>TGC	p.S3865C	DNHD1_uc001mea.3_Missense_Mutation_p.S134C|DNHD1_uc001meb.2_Missense_Mutation_p.S133C|DNHD1_uc001mec.2_Missense_Mutation_p.S133C|DNHD1_uc010rao.1_Missense_Mutation_p.S123C|DNHD1_uc009yfg.2_5'Flank	NM_144666	NP_653267	Q96M86	DNHD1_HUMAN	dynein heavy chain domain 1 isoform 1	3865					microtubule-based movement	dynein complex	microtubule motor activity			ovary(2)	2		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.171)		Epithelial(150;3.93e-08)|BRCA - Breast invasive adenocarcinoma(625;0.13)		AAAGGCCCTAAGCCAACTGCA	0.507			NA											16	77					0	0	0.003163	0	0
OR10A4	283297	broad.mit.edu	37	11	6897968	6897968	+	Silent	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr11:6897968C>T	uc010rat.1	+	1	90	c.90C>T	c.(88-90)CTC>CTT	p.L30L		NM_207186	NP_997069	Q9H209	O10A4_HUMAN	olfactory receptor, family 10, subfamily A,	30	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		Medulloblastoma(188;0.0523)|all_neural(188;0.236)		Epithelial(150;4.78e-08)|BRCA - Breast invasive adenocarcinoma(625;0.129)		TACTGTTTCTCCTTTTCTTGA	0.443			NA											20	105					0	0	0.007413	0	0
HPS5	11234	broad.mit.edu	37	11	18313334	18313334	+	Missense_Mutation	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr11:18313334C>T	uc001mod.1	-	16	2373	c.2095G>A	c.(2095-2097)GAA>AAA	p.E699K	HPS5_uc001moe.1_Missense_Mutation_p.E585K|HPS5_uc001mof.1_Missense_Mutation_p.E585K	NM_181507	NP_852608	Q9UPZ3	HPS5_HUMAN	Hermansky-Pudlak syndrome 5 isoform a	699						cytosol				ovary(1)|pancreas(1)|skin(1)	3						ACAGATTCTTCATTGCCTAAA	0.363			NA							Hermansky-Pudlak_syndrome				17	43					0	0	0.004007	0	0
HPS5	11234	broad.mit.edu	37	11	18316688	18316688	+	Missense_Mutation	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr11:18316688C>T	uc001mod.1	-	14	1941	c.1663G>A	c.(1663-1665)GAG>AAG	p.E555K	HPS5_uc001moe.1_Missense_Mutation_p.E441K|HPS5_uc001mof.1_Missense_Mutation_p.E441K	NM_181507	NP_852608	Q9UPZ3	HPS5_HUMAN	Hermansky-Pudlak syndrome 5 isoform a	555						cytosol				ovary(1)|pancreas(1)|skin(1)	3						CCAATCTTCTCAGTAGTTTTA	0.398			NA							Hermansky-Pudlak_syndrome				10	38					0	0	0.006214	0	0
HPS5	11234	broad.mit.edu	37	11	18327041	18327041	+	Splice_Site	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr11:18327041C>T	uc001mod.1	-	8	1103	c.825_splice	c.e8-1	p.R275_splice	HPS5_uc001moe.1_Splice_Site_p.R161_splice|HPS5_uc001mof.1_Splice_Site_p.R161_splice	NM_181507	NP_852608	Q9UPZ3	HPS5_HUMAN	Hermansky-Pudlak syndrome 5 isoform a							cytosol				ovary(1)|pancreas(1)|skin(1)	3						AGGTTCTGATCTAGAAAGTAA	0.343			NA							Hermansky-Pudlak_syndrome				4	25					0	0	0.009096	0	0
ANO5	203859	broad.mit.edu	37	11	22248914	22248914	+	Missense_Mutation	SNP	G	G	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr11:22248914G>T	uc001mqi.2	+	7	747	c.430G>T	c.(430-432)GCT>TCT	p.A144S	ANO5_uc001mqj.2_Missense_Mutation_p.A143S	NM_213599	NP_998764	Q75V66	ANO5_HUMAN	anoctamin 5 isoform a	144	Cytoplasmic (Potential).					chloride channel complex|endoplasmic reticulum membrane	chloride channel activity			central_nervous_system(3)|ovary(1)	4						AGTTACCTATGCTGAAGTCTT	0.433			NA											14	38					8.60227e-14	1.11224e-13	0.004007	1	0
Unknown	0	broad.mit.edu	37	11	31115602	31115602	+	Missense_Mutation	SNP	T	T	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr11:31115602T>A	uc009yjk.1	-	4	526	c.457A>T	c.(457-459)ACC>TCC	p.T153S	uc009yjl.1_Missense_Mutation_p.T81S|DCDC1_uc001msu.1_Missense_Mutation_p.T324S					RecName: Full=Doublecortin domain-containing protein 5;												NA						GGTACCTTGGTGATCAGCCAC	0.537			NA											12	72					0	0	0.001855	0	0
C11orf41	25758	broad.mit.edu	37	11	33565707	33565707	+	Missense_Mutation	SNP	T	T	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr11:33565707T>A	uc001mup.3	+	1	1831	c.1707T>A	c.(1705-1707)GAT>GAA	p.D569E	C11orf41_uc001mun.1_Missense_Mutation_p.D569E	NM_012194	NP_036326	Q6ZVL6	CK041_HUMAN	hypothetical protein LOC25758	569						integral to membrane				ovary(2)	2						ATGGAACAGATACAGGTTCTG	0.453			NA											14	69					0	0	0.001855	0	0
PDHX	8050	broad.mit.edu	37	11	34969155	34969155	+	Splice_Site	SNP	T	T	C			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr11:34969155T>C	uc001mvt.2	+	3	868	c.342_splice	c.e3+2	p.V114_splice	PDHX_uc010rep.1_Splice_Site_p.V99_splice|PDHX_uc010req.1_Splice_Site_p.V114_splice	NM_003477	NP_003468	O00330	ODPX_HUMAN	pyruvate dehydrogenase complex, component X						pyruvate metabolic process|regulation of acetyl-CoA biosynthetic process from pyruvate	mitochondrial matrix	acyltransferase activity			kidney(1)	1	all_epithelial(35;0.115)|Lung NSC(22;0.218)|all_lung(20;0.242)	all_hematologic(20;0.124)	STAD - Stomach adenocarcinoma(6;0.00113)			AAAATCGTGGTAAGTTTTTAT	0.348			NA											3	64					0	0	0.004672	0	0
RAG2	5897	broad.mit.edu	37	11	36614834	36614834	+	Missense_Mutation	SNP	G	G	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr11:36614834G>T	uc001mwv.3	-	2	1073	c.885C>A	c.(883-885)AAC>AAA	p.N295K	C11orf74_uc010rfd.1_5'Flank|C11orf74_uc001mww.1_5'Flank|C11orf74_uc001mwx.1_5'Flank|C11orf74_uc001mwy.1_5'Flank|C11orf74_uc001mwz.1_5'Flank|C11orf74_uc010rfe.1_5'Flank	NM_000536	NP_000527	P55895	RAG2_HUMAN	recombination activating gene 2	295					chromatin modification|pre-B cell allelic exclusion|somatic diversification of immunoglobulins|T cell differentiation in thymus|V(D)J recombination	nucleus	chromatin binding|DNA binding|endonuclease activity|methylated histone residue binding|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-4,5-bisphosphate binding|zinc ion binding			skin(3)|ovary(1)|pancreas(1)	5	all_lung(20;0.226)	all_hematologic(20;0.00756)				TTTCTATCTTGTTGTCCTCTA	0.388			NA							Familial_Hemophagocytic_Lymphohistiocytosis				45	139					3.76604e-16	4.98022e-16	0.010771	1	0
MYBPC3	4607	broad.mit.edu	37	11	47367838	47367838	+	Missense_Mutation	SNP	G	G	C			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr11:47367838G>C	uc001nfa.3	-	12	1065	c.1010C>G	c.(1009-1011)GCC>GGC	p.A337G		NM_000256	NP_000247	Q14896	MYPC3_HUMAN	myosin binding protein C, cardiac	337					cardiac muscle contraction|cell adhesion|muscle filament sliding|regulation of muscle filament sliding|regulation of striated muscle contraction|ventricular cardiac muscle tissue morphogenesis	C zone|cytosol|striated muscle myosin thick filament	actin binding|ATPase activator activity|metal ion binding|myosin heavy chain binding|structural constituent of muscle|titin binding			ovary(2)|central_nervous_system(1)	3				Lung(87;0.176)		GTACTGGAAGGCGATGCGCTC	0.612			NA											12	18					0	0	0.010729	0	0
OR4S2	219431	broad.mit.edu	37	11	55418972	55418972	+	Missense_Mutation	SNP	C	C	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr11:55418972C>A	uc001nhs.1	+	1	593	c.593C>A	c.(592-594)ACA>AAA	p.T198K		NM_001004059	NP_001004059	Q8NH73	OR4S2_HUMAN	olfactory receptor, family 4, subfamily S,	198	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)	3		all_epithelial(135;0.0748)				GTTGTTGTGACAGCCAACAGT	0.453			NA											28	90					2.44723e-14	3.18118e-14	0.004656	1	0
OR5W2	390148	broad.mit.edu	37	11	55681456	55681456	+	Silent	SNP	G	G	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr11:55681456G>A	uc010rir.1	-	1	603	c.603C>T	c.(601-603)ACC>ACT	p.T201T		NM_001001960	NP_001001960	Q8NH69	OR5W2_HUMAN	olfactory receptor, family 5, subfamily W,	201	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						AACCAAAGACGGTGAATAACA	0.388	Melanoma(48;171 1190 15239 43886 49348)		NA											7	19					0	0	0.004482	0	0
OR5M11	219487	broad.mit.edu	37	11	56310672	56310672	+	Missense_Mutation	SNP	G	G	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr11:56310672G>A	uc010rjl.1	-	1	62	c.62C>T	c.(61-63)CCG>CTG	p.P21L		NM_001005245	NP_001005245	Q96RB7	OR5MB_HUMAN	olfactory receptor, family 5, subfamily M,	21	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						CTGGAGTTCCGGGCAATCTGT	0.458			NA											10	42					0	0	0.008291	0	0
OR5M1	390168	broad.mit.edu	37	11	56380893	56380893	+	Missense_Mutation	SNP	C	C	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr11:56380893C>A	uc001nja.1	-	1	86	c.86G>T	c.(85-87)GGG>GTG	p.G29V		NM_001004740	NP_001004740	Q8NGP8	OR5M1_HUMAN	olfactory receptor, family 5, subfamily M,	29	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1						AAGGAATACCCCAAACAGGAT	0.473			NA											10	32					1.58986e-06	1.81627e-06	0.008291	1	0
LRRC55	219527	broad.mit.edu	37	11	56949837	56949837	+	Missense_Mutation	SNP	G	G	C			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr11:56949837G>C	uc001njl.1	+	1	617	c.470G>C	c.(469-471)CGC>CCC	p.R157P		NM_001005210	NP_001005210	Q6ZSA7	LRC55_HUMAN	leucine rich repeat containing 55	127	LRR 3.					integral to membrane					0						CATGCCAAGCGCTTGGCACAC	0.577			NA											10	27					0	0	0.006214	0	0
CTNND1	1500	broad.mit.edu	37	11	57572182	57572182	+	Missense_Mutation	SNP	G	G	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr11:57572182G>A	uc001nmc.3	+	9	2223	c.1652G>A	c.(1651-1653)TGT>TAT	p.C551Y	CTNND1_uc001nlh.1_Missense_Mutation_p.C551Y|CTNND1_uc001nlu.3_Missense_Mutation_p.C450Y|CTNND1_uc001nlt.3_Missense_Mutation_p.C450Y|CTNND1_uc001nls.3_Missense_Mutation_p.C450Y|CTNND1_uc001nlw.3_Missense_Mutation_p.C450Y|CTNND1_uc001nmf.3_Missense_Mutation_p.C551Y|CTNND1_uc001nmd.3_Missense_Mutation_p.C497Y|CTNND1_uc001nlk.3_Missense_Mutation_p.C497Y|CTNND1_uc001nme.3_Missense_Mutation_p.C551Y|CTNND1_uc001nll.3_Missense_Mutation_p.C497Y|CTNND1_uc001nmg.3_Missense_Mutation_p.C497Y|CTNND1_uc001nlj.3_Missense_Mutation_p.C497Y|CTNND1_uc001nlr.3_Missense_Mutation_p.C497Y|CTNND1_uc001nlp.3_Missense_Mutation_p.C497Y|CTNND1_uc001nlx.3_Missense_Mutation_p.C228Y|CTNND1_uc001nlz.3_Missense_Mutation_p.C228Y|CTNND1_uc009ymn.2_Missense_Mutation_p.C228Y|CTNND1_uc001nlm.3_Missense_Mutation_p.C551Y|CTNND1_uc001nly.3_Missense_Mutation_p.C228Y|CTNND1_uc001nmb.3_Missense_Mutation_p.C228Y|CTNND1_uc001nma.3_Missense_Mutation_p.C228Y|CTNND1_uc001nmi.3_Missense_Mutation_p.C450Y|CTNND1_uc001nmh.3_Missense_Mutation_p.C551Y|CTNND1_uc001nlq.3_Missense_Mutation_p.C450Y|CTNND1_uc001nln.3_Missense_Mutation_p.C551Y|CTNND1_uc001nli.3_Missense_Mutation_p.C551Y|CTNND1_uc001nlo.3_Missense_Mutation_p.C450Y|CTNND1_uc001nlv.3_Missense_Mutation_p.C450Y	NM_001085458	NP_001078927	O60716	CTND1_HUMAN	catenin, delta 1 isoform 1ABC	551	ARM 5.				adherens junction organization|cell junction assembly|negative regulation of canonical Wnt receptor signaling pathway|regulation of transcription, DNA-dependent|transcription, DNA-dependent|Wnt receptor signaling pathway	cytosol|midbody|nucleus	cadherin binding|protein binding|receptor binding			breast(4)|ovary(1)|kidney(1)	6		all_epithelial(135;0.155)				CTTCGGGAATGTGATGGTTTA	0.463			NA											6	22					0	0	0.001984	0	0
OR10Q1	219960	broad.mit.edu	37	11	57995949	57995949	+	Silent	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr11:57995949C>T	uc010rkd.1	-	1	399	c.399G>A	c.(397-399)CCG>CCA	p.P133P		NM_001004471	NP_001004471	Q8NGQ4	O10Q1_HUMAN	olfactory receptor, family 10, subfamily Q,	133	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2		Breast(21;0.0589)				TGTAGTGCAGCGGGTGGCAGA	0.612			NA											13	24					0	0	0.013537	0	0
OR5B21	219968	broad.mit.edu	37	11	58275103	58275103	+	Missense_Mutation	SNP	G	G	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr11:58275103G>T	uc010rki.1	-	1	476	c.476C>A	c.(475-477)GCA>GAA	p.A159E		NM_001005218	NP_001005218	A6NL26	OR5BL_HUMAN	olfactory receptor, family 5, subfamily B,	159	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(3)	3	Esophageal squamous(5;0.0027)	Breast(21;0.0778)				GAAGGTGCCTGCTGCATGGAT	0.507			NA											12	34					2.27111e-07	2.64023e-07	0.013537	1	0
OR5B21	219968	broad.mit.edu	37	11	58275540	58275540	+	Missense_Mutation	SNP	C	C	G			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr11:58275540C>G	uc010rki.1	-	1	39	c.39G>C	c.(37-39)TTG>TTC	p.L13F		NM_001005218	NP_001005218	A6NL26	OR5BL_HUMAN	olfactory receptor, family 5, subfamily B,	13	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(3)	3	Esophageal squamous(5;0.0027)	Breast(21;0.0778)				CTGTTAATCCCAAGAGGATAA	0.443			NA											12	34					0	0	0.013537	0	0
GLYAT	10249	broad.mit.edu	37	11	58477469	58477469	+	Missense_Mutation	SNP	G	G	C			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr11:58477469G>C	uc001nnb.2	-	6	816	c.661C>G	c.(661-663)CTA>GTA	p.L221V		NM_201648	NP_964011	Q6IB77	GLYAT_HUMAN	glycine-N-acyltransferase isoform a	221					acyl-CoA metabolic process|response to toxin|xenobiotic metabolic process	mitochondrial matrix	glycine N-acyltransferase activity|glycine N-benzoyltransferase activity				0		Breast(21;0.0044)|all_epithelial(135;0.0157)			Glycine(DB00145)	TGGTCCATTAGATCCCAGCAC	0.552			NA											21	53					0	0	0.014323	0	0
GLYAT	10249	broad.mit.edu	37	11	58491902	58491902	+	Missense_Mutation	SNP	G	G	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr11:58491902G>T	uc001nnb.2	-	2	223	c.68C>A	c.(67-69)CCA>CAA	p.P23Q	GLYAT_uc001nnc.2_Missense_Mutation_p.P23Q	NM_201648	NP_964011	Q6IB77	GLYAT_HUMAN	glycine-N-acyltransferase isoform a	23					acyl-CoA metabolic process|response to toxin|xenobiotic metabolic process	mitochondrial matrix	glycine N-acyltransferase activity|glycine N-benzoyltransferase activity				0		Breast(21;0.0044)|all_epithelial(135;0.0157)			Glycine(DB00145)	TAAGGATGCTGGGAGGCTCTT	0.418			NA											8	36					5.18039e-06	5.81293e-06	0.00308	1	0
ZP1	22917	broad.mit.edu	37	11	60636693	60636693	+	Missense_Mutation	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr11:60636693C>T	uc001nqd.2	+	2	292	c.272C>T	c.(271-273)CCT>CTT	p.P91L	ZP1_uc001nqe.2_5'Flank	NM_207341	NP_997224	P60852	ZP1_HUMAN	zona pellucida glycoprotein 1 precursor	91	Extracellular (Potential).				single fertilization	integral to membrane|plasma membrane|proteinaceous extracellular matrix					0						CCGCAGGAGCCTGCAGTCTTC	0.577			NA											16	30					0	0	0.006122	0	0
TMEM132A	54972	broad.mit.edu	37	11	60699590	60699590	+	Missense_Mutation	SNP	G	G	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr11:60699590G>T	uc001nqj.2	+	7	1540	c.1347G>T	c.(1345-1347)CAG>CAT	p.Q449H	TMEM132A_uc001nqi.2_Missense_Mutation_p.Q450H|TMEM132A_uc001nqk.2_Missense_Mutation_p.Q462H|TMEM132A_uc001nql.1_3'UTR|TMEM132A_uc001nqm.2_5'Flank	NM_178031	NP_821174	Q24JP5	T132A_HUMAN	transmembrane protein 132A isoform b	449	Extracellular (Potential).					endoplasmic reticulum membrane|Golgi membrane|integral to membrane				skin(1)	1						CCAACACACAGGTCCTGCAGG	0.622			NA											30	54					7.01153e-11	8.67924e-11	0.007291	1	0
CD5	921	broad.mit.edu	37	11	60889133	60889133	+	Missense_Mutation	SNP	G	G	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr11:60889133G>A	uc009ynk.2	+	6	959	c.856G>A	c.(856-858)GAA>AAA	p.E286K		NM_014207	NP_055022	P06127	CD5_HUMAN	CD5 molecule precursor	286	Extracellular (Potential).|SRCR 3.				cell proliferation|cell recognition	integral to plasma membrane	scavenger receptor activity			ovary(1)	1		all_lung(304;5.94e-05)|Lung NSC(402;7.26e-05)		BRCA - Breast invasive adenocarcinoma(625;0.000946)|Lung(977;0.0086)|LUSC - Lung squamous cell carcinoma(625;0.0528)		CAGCATCTGTGAAGGCACCGT	0.647			NA											36	61					0	0	0.004289	0	0
DAK	26007	broad.mit.edu	37	11	61106638	61106638	+	Silent	SNP	G	G	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr11:61106638G>A	uc001nre.2	+	4	551	c.294G>A	c.(292-294)CAG>CAA	p.Q98Q	DDB1_uc010rlf.1_Intron|DAK_uc009ynm.1_Silent_p.Q28Q	NM_015533	NP_056348	Q3LXA3	DHAK_HUMAN	dihydroxyacetone kinase 2	98	DhaK.				glycerol metabolic process	cytosol	ATP binding|FAD-AMP lyase (cyclizing) activity|glycerone kinase activity|metal ion binding				0						CCGTGGCCCAGGCCGGCACAG	0.672			NA											36	53					0	0	0.004289	0	0
DAGLA	747	broad.mit.edu	37	11	61493493	61493493	+	Missense_Mutation	SNP	C	C	G			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr11:61493493C>G	uc001nsa.2	+	6	686	c.575C>G	c.(574-576)ACC>AGC	p.T192S		NM_006133	NP_006124	Q9Y4D2	DGLA_HUMAN	neural stem cell-derived dendrite regulator	192	Cytoplasmic (Potential).				cell death|lipid catabolic process|platelet activation	integral to membrane|plasma membrane	acylglycerol lipase activity|metal ion binding|triglyceride lipase activity			ovary(2)|central_nervous_system(1)	3				READ - Rectum adenocarcinoma(4;0.219)		GGTCAAGCCACCAGCTGGTCG	0.607			NA											6	159					0	0	0.00308	0	0
AHNAK	79026	broad.mit.edu	37	11	62294197	62294197	+	Silent	SNP	C	C	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr11:62294197C>A	uc001ntl.2	-	5	7992	c.7692G>T	c.(7690-7692)GGG>GGT	p.G2564G	AHNAK_uc001ntk.1_Intron	NM_001620	NP_001611	Q09666	AHNK_HUMAN	AHNAK nucleoprotein isoform 1	2564					nervous system development	nucleus	protein binding			ovary(10)|pancreas(4)|skin(4)|upper_aerodigestive_tract(1)	19		Melanoma(852;0.155)				TTAACTTAGGCCCTTTCAACT	0.483			NA											53	99					4.25531e-23	5.81253e-23	0.01441	1	0
INTS5	80789	broad.mit.edu	37	11	62416029	62416029	+	Missense_Mutation	SNP	A	A	G			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr11:62416029A>G	uc001nud.2	-	2	1576	c.1523T>C	c.(1522-1524)GTC>GCC	p.V508A	GANAB_uc001nua.2_5'Flank|GANAB_uc001nub.2_5'Flank|GANAB_uc001nuc.2_5'Flank|GANAB_uc010rma.1_5'Flank|GANAB_uc010rmb.1_5'Flank	NM_030628	NP_085131	Q6P9B9	INT5_HUMAN	integrator complex subunit 5	508					snRNA processing	integral to membrane|integrator complex	protein binding			ovary(2)	2						CCGGGTATAGACAGACAGCAG	0.577			NA											28	150					0	0	0.007291	0	0
ZBTB3	79842	broad.mit.edu	37	11	62519745	62519745	+	Silent	SNP	G	G	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr11:62519745G>A	uc001nuz.2	-	2	1664	c.1542C>T	c.(1540-1542)GAC>GAT	p.D514D		NM_024784	NP_079060	Q9H5J0	ZBTB3_HUMAN	zinc finger and BTB domain containing 3	514	C2H2-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|ovary(1)	3						GGCGGTAGAGGTCCCCTGACT	0.602			NA											34	58					0	0	0.003271	0	0
SLC3A2	6520	broad.mit.edu	37	11	62655685	62655685	+	Missense_Mutation	SNP	G	G	C			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr11:62655685G>C	uc001nwd.2	+	11	1749	c.1525G>C	c.(1525-1527)GTG>CTG	p.V509L	SLC3A2_uc001nwb.2_Missense_Mutation_p.V540L|SLC3A2_uc001nwc.2_Missense_Mutation_p.V510L|SLC3A2_uc001nwe.2_Missense_Mutation_p.V478L|SLC3A2_uc001nwf.2_Missense_Mutation_p.V447L|SLC3A2_uc001nwg.2_Missense_Mutation_p.V408L	NM_002394	NP_002385	P08195	4F2_HUMAN	solute carrier family 3, member 2 isoform c	509	Extracellular (Potential).				blood coagulation|carbohydrate metabolic process|cell growth|cellular nitrogen compound metabolic process|leucine import|leukocyte migration|tryptophan transport	apical plasma membrane|cell surface|integral to membrane|melanosome	calcium:sodium antiporter activity|catalytic activity|cation binding|neutral amino acid transmembrane transporter activity|protein binding				0						CAACATGACTGTGAAGGTAAG	0.537			NA											35	63					0	0	0.012213	0	0
SLC22A6	9356	broad.mit.edu	37	11	62751918	62751918	+	Missense_Mutation	SNP	G	G	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr11:62751918G>T	uc001nwk.2	-	1	552	c.245C>A	c.(244-246)ACC>AAC	p.T82N	SLC22A6_uc001nwl.2_Missense_Mutation_p.T82N|SLC22A6_uc001nwj.2_Missense_Mutation_p.T82N|SLC22A6_uc001nwm.2_Missense_Mutation_p.T82N	NM_004790	NP_004781	Q4U2R8	S22A6_HUMAN	solute carrier family 22 member 6 isoform a	82	Extracellular (Potential).				alpha-ketoglutarate transport	basolateral plasma membrane|integral to plasma membrane|membrane fraction	inorganic anion exchanger activity|protein binding				0						CTGCGGGGAGGTGAAGCGGAG	0.662			NA											28	95					7.41945e-09	8.93287e-09	0.005443	1	0
HRASLS5	117245	broad.mit.edu	37	11	63235916	63235916	+	Nonsense_Mutation	SNP	C	C	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr11:63235916C>A	uc001nwy.2	-	4	571	c.397G>T	c.(397-399)GGA>TGA	p.G133*	HRASLS5_uc001nwz.2_Nonsense_Mutation_p.G123*|HRASLS5_uc010rmq.1_Nonsense_Mutation_p.G133*|HRASLS5_uc009yos.2_Intron	NM_054108	NP_473449	Q96KN8	HRSL5_HUMAN	HRAS-like suppressor family, member 5 isoform 1	133										ovary(1)	1						ATCAGGTCTCCAGGTCTGGGT	0.443			NA											21	47					1.87028e-06	2.13327e-06	0.012319	1	0
TRPT1	83707	broad.mit.edu	37	11	63991664	63991664	+	Missense_Mutation	SNP	C	C	G			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr11:63991664C>G	uc001nyo.2	-	7	792	c.578G>C	c.(577-579)CGC>CCC	p.R193P	TRPT1_uc010rnc.1_Missense_Mutation_p.R194P|TRPT1_uc010rnd.1_Missense_Mutation_p.R195P|TRPT1_uc001nyn.2_Missense_Mutation_p.R144P|TRPT1_uc010rne.1_Intron|TRPT1_uc010rnf.1_Missense_Mutation_p.R193P|NUDT22_uc009ypd.2_5'Flank|NUDT22_uc001nyp.3_5'Flank|NUDT22_uc009ype.2_5'Flank|NUDT22_uc001nyq.3_5'Flank	NM_001033678	NP_001028850	Q86TN4	TRPT1_HUMAN	tRNA phosphotransferase 1 isoform 1	193							tRNA 2'-phosphotransferase activity				0						ATTGGCAGAGCGGAAGAAGGG	0.567			NA											16	75					0	0	0.004007	0	0
CCDC88B	283234	broad.mit.edu	37	11	64120219	64120219	+	Silent	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr11:64120219C>T	uc001nzy.2	+	20	3404	c.3360C>T	c.(3358-3360)CAC>CAT	p.H1120H	CCDC88B_uc009ypo.1_Silent_p.H1117H|CCDC88B_uc001oaa.2_Silent_p.H272H|CCDC88B_uc001oab.1_5'Flank|CCDC88B_uc001oac.2_5'Flank	NM_032251	NP_115627	A6NC98	CC88B_HUMAN	coiled-coil domain containing 88	1120	Potential.				microtubule cytoskeleton organization	cytoplasm	microtubule binding			ovary(3)|skin(1)	4						ATCCCAGGCACGAGCAGCTGC	0.677			NA											6	47					0	0	0.001168	0	0
NRXN2	9379	broad.mit.edu	37	11	64374937	64374937	+	Missense_Mutation	SNP	C	C	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr11:64374937C>A	uc001oap.2	-	8	2243	c.1732G>T	c.(1732-1734)GGC>TGC	p.G578C	NRXN2_uc001oar.2_Missense_Mutation_p.G1624C|NRXN2_uc001oas.2_Missense_Mutation_p.G1554C|NRXN2_uc001oao.2_Missense_Mutation_p.G264C|NRXN2_uc001oaq.2_Missense_Mutation_p.G1291C	NM_138734	NP_620063	P58401	NRX2B_HUMAN	neurexin 2 isoform beta precursor	578	Extracellular (Potential).				cell adhesion	integral to membrane				upper_aerodigestive_tract(2)|central_nervous_system(2)|skin(2)|ovary(2)|kidney(1)|pancreas(1)	10						TCCACTGCGCCCGGCGGGCCC	0.736			NA											11	22					1.08611e-07	1.27695e-07	0.010729	1	0
PYGM	5837	broad.mit.edu	37	11	64518939	64518939	+	Splice_Site	SNP	C	C	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr11:64518939C>A	uc001oax.3	-	16	2645	c.1828_splice	c.e16-1	p.A610_splice	PYGM_uc001oay.3_Splice_Site_p.A522_splice	NM_005609	NP_005600	P11217	PYGM_HUMAN	muscle glycogen phosphorylase isoform 1						glucose metabolic process|glycogen catabolic process	cytosol	glycogen phosphorylase activity|protein binding			ovary(2)	2					Pyridoxal Phosphate(DB00114)	CAGGTGCAGCCTGAGGGGACA	0.602			NA											44	97					5.48756e-27	7.57409e-27	0.011902	1	0
NAALADL1	10004	broad.mit.edu	37	11	64815843	64815843	+	Missense_Mutation	SNP	G	G	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr11:64815843G>A	uc001ocn.2	-	9	1229	c.1213C>T	c.(1213-1215)CGC>TGC	p.R405C	NAALADL1_uc010rnw.1_5'UTR|NAALADL1_uc009ypz.2_RNA	NM_005468	NP_005459	Q9UQQ1	NALDL_HUMAN	N-acetylated alpha-linked acidic	405	NAALADase.|Extracellular (Potential).				proteolysis	apical plasma membrane|integral to membrane	carboxypeptidase activity|dipeptidase activity|metal ion binding|metallopeptidase activity				0						ATTGATCTGCGAGGACGCCAG	0.597			NA											16	52					0	0	0.004007	0	0
SIPA1	6494	broad.mit.edu	37	11	65417286	65417286	+	Missense_Mutation	SNP	G	G	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr11:65417286G>T	uc001ofb.2	+	12	2863	c.2696G>T	c.(2695-2697)AGG>ATG	p.R899M	SIPA1_uc010rom.1_Missense_Mutation_p.R797M|SIPA1_uc001ofd.2_Missense_Mutation_p.R899M	NM_006747	NP_006738	Q96FS4	SIPA1_HUMAN	signal-induced proliferation-associated protein	899					cell proliferation|cytoskeleton organization|intracellular signal transduction|negative regulation of cell adhesion|negative regulation of cell cycle|negative regulation of cell growth	cytosol|endomembrane system|membrane|perinuclear region of cytoplasm	Rap GTPase activator activity				0						CCGGAGCTGAGGGCCTCCTTT	0.627			NA											30	54					5.77227e-19	7.76769e-19	0.008361	1	0
CATSPER1	117144	broad.mit.edu	37	11	65793536	65793536	+	Silent	SNP	G	G	C			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr11:65793536G>C	uc001ogt.2	-	1	453	c.315C>G	c.(313-315)GTC>GTG	p.V105V		NM_053054	NP_444282	Q8NEC5	CTSR1_HUMAN	sperm-associated cation channel 1	105	His-rich.|Cytoplasmic (Potential).				cell differentiation|multicellular organismal development|spermatogenesis	cilium|flagellar membrane|integral to membrane	protein binding			ovary(2)	2						GGTGGGAGGGGACGGCGCCTT	0.607			NA											44	112					0	0	0.01441	0	0
SF3B2	10992	broad.mit.edu	37	11	65827291	65827291	+	Silent	SNP	G	G	C			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr11:65827291G>C	uc001ogy.1	+	13	1480	c.1440G>C	c.(1438-1440)GTG>GTC	p.V480V		NM_006842	NP_006833	Q13435	SF3B2_HUMAN	splicing factor 3B subunit 2	480					interspecies interaction between organisms	catalytic step 2 spliceosome|nucleoplasm|U12-type spliceosomal complex	nucleic acid binding|protein binding			ovary(2)|breast(1)	3						TGCACGATGTGACAGCGCAGG	0.557			NA											3	109					0	0	0.004672	0	0
RIN1	9610	broad.mit.edu	37	11	66102012	66102012	+	Missense_Mutation	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr11:66102012C>T	uc001ohn.1	-	6	1385	c.1258G>A	c.(1258-1260)GAG>AAG	p.E420K	RIN1_uc010roy.1_Missense_Mutation_p.E113K|RIN1_uc009yrd.1_Missense_Mutation_p.E113K|RIN1_uc010roz.1_Missense_Mutation_p.E315K|RIN1_uc010rpa.1_Missense_Mutation_p.E315K	NM_004292	NP_004283	Q13671	RIN1_HUMAN	ras inhibitor RIN1	420	Ras and 14-3-3 protein binding region.				endocytosis|signal transduction	cytoplasm|cytoskeleton|plasma membrane	GTPase activator activity|protein binding			lung(2)|breast(1)	3						AGCAGCTTCTCAGGGCCCAGC	0.701			NA											5	6					0	0	0.000602	0	0
CCDC87	55231	broad.mit.edu	37	11	66357977	66357977	+	Missense_Mutation	SNP	T	T	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr11:66357977T>A	uc001oiq.3	-	1	2578	c.2510A>T	c.(2509-2511)CAC>CTC	p.H837L	CCS_uc001oir.2_5'Flank	NM_018219	NP_060689	Q9NVE4	CCD87_HUMAN	coiled-coil domain containing 87	837										ovary(1)|skin(1)	2						GGTTGACTGGTGGGGATCCTT	0.577			NA											104	205					0	0	0.01441	0	0
CLCF1	23529	broad.mit.edu	37	11	67132763	67132763	+	Silent	SNP	G	G	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr11:67132763G>T	uc001okq.2	-	3	718	c.522C>A	c.(520-522)GCC>GCA	p.A174A	LOC100130987_uc010rpo.1_Intron|CLCF1_uc010rpp.1_Silent_p.A164A	NM_013246	NP_037378	Q9UBD9	CLCF1_HUMAN	cardiotrophin-like cytokine factor 1 precursor	174					B cell differentiation|cytokine-mediated signaling pathway|JAK-STAT cascade|negative regulation of neuron apoptosis|positive regulation of astrocyte differentiation|positive regulation of B cell proliferation|positive regulation of immunoglobulin production|positive regulation of isotype switching to IgE isotypes|positive regulation of tyrosine phosphorylation of Stat3 protein	extracellular space	ciliary neurotrophic factor receptor binding|cytokine activity|growth factor activity|protein heterodimerization activity				0			BRCA - Breast invasive adenocarcinoma(15;2.39e-06)			AGTCACTGTGGGCAGGGCCAG	0.637			NA											10	56					3.07112e-06	3.46216e-06	0.010729	1	0
NDUFS8	4728	broad.mit.edu	37	11	67800450	67800450	+	Missense_Mutation	SNP	G	G	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr11:67800450G>T	uc001onc.2	+	4	277	c.170G>T	c.(169-171)CGC>CTC	p.R57L	NDUFS8_uc010rpz.1_Missense_Mutation_p.R57L|NDUFS8_uc009ysb.1_Intron|NDUFS8_uc009ysc.1_Missense_Mutation_p.R57L	NM_002496	NP_002487	O00217	NDUS8_HUMAN	NADH dehydrogenase ubiquinone Fe-S 8 precursor	57					mitochondrial electron transport, NADH to ubiquinone|mitochondrial respiratory chain complex I assembly|response to oxidative stress|transport	mitochondrial respiratory chain complex I	4 iron, 4 sulfur cluster binding|electron carrier activity|metal ion binding|NADH dehydrogenase (ubiquinone) activity			skin(1)	1					NADH(DB00157)	CGGGCAGCCCGCACCCTGCTG	0.652	Colon(116;1205 2770 20054)		NA											44	62					1.61863e-15	2.12308e-15	0.01441	1	0
CCND1	595	broad.mit.edu	37	11	69456155	69456155	+	Missense_Mutation	SNP	A	A	C			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr11:69456155A>C	uc001opa.2	+	1	283	c.74A>C	c.(73-75)GAC>GCC	p.D25A		NM_053056	NP_444284	P24385	CCND1_HUMAN	cyclin D1	25					cell division|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|mitotic cell cycle G1/S transition DNA damage checkpoint|positive regulation of cyclin-dependent protein kinase activity|positive regulation of protein phosphorylation|response to drug|response to UV-A|S phase of mitotic cell cycle	cyclin-dependent protein kinase holoenzyme complex|cytosol|membrane|nucleoplasm	protein kinase binding			ovary(1)|lung(1)	2	all_cancers(3;2.01e-114)|all_epithelial(3;3.59e-122)|Breast(3;5.4e-34)|all_lung(4;1.99e-21)|Lung NSC(4;4.65e-21)|Hepatocellular(3;8.22e-16)|Melanoma(5;1.89e-05)|Ovarian(3;0.0348)		Epithelial(3;7.2e-57)|all cancers(3;7.75e-51)|BRCA - Breast invasive adenocarcinoma(2;4.9e-48)|Lung(3;1.13e-16)|LUSC - Lung squamous cell carcinoma(11;3.74e-15)|STAD - Stomach adenocarcinoma(18;0.0278)|LUAD - Lung adenocarcinoma(13;0.0537)		Arsenic trioxide(DB01169)	CTCCTCAACGACCGGGTGCTG	0.647	Pancreas(65;393 884 2788 21700 24360 27795 36895)		NA	T	IGH@|FSTL3	CLL|B-ALL|breast					Multiple Myeloma(6;0.086)			33	120					0	0	0.012213	0	0
FOLR3	2352	broad.mit.edu	37	11	71850011	71850011	+	Missense_Mutation	SNP	G	G	C			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr11:71850011G>C	uc001ory.1	+	3	351	c.301G>C	c.(301-303)GTC>CTC	p.V101L	FOLR3_uc001orx.1_Missense_Mutation_p.S58T			P41439	FOLR3_HUMAN	SubName: Full=FOLR3 protein; Flags: Fragment;	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					folic acid transport	extracellular region|extrinsic to membrane|membrane fraction	folic acid binding|receptor activity				0					Folic Acid(DB00158)	ACCCAGTGCAGTCCCTGGAAG	0.572			NA											4	29					0	0	0.009096	0	0
INPPL1	3636	broad.mit.edu	37	11	71940249	71940249	+	Missense_Mutation	SNP	G	G	T	rs17847214	byFrequency	TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr11:71940249G>T	uc001osf.2	+	5	781	c.634G>T	c.(634-636)GCT>TCT	p.A212S	INPPL1_uc001osg.2_5'UTR	NM_001567	NP_001558	O15357	SHIP2_HUMAN	inositol polyphosphate phosphatase-like 1	212					actin filament organization|cell adhesion|endocytosis	actin cortical patch|cytosol	actin binding|SH2 domain binding|SH3 domain binding			skin(2)|ovary(1)|breast(1)	4						CCGTACCCTCGCTACCTCATG	0.622			NA											5	36					3.59834e-05	3.94026e-05	0.001168	1	0
WNT11	7481	broad.mit.edu	37	11	75902715	75902715	+	Missense_Mutation	SNP	C	C	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr11:75902715C>A	uc001oxe.2	-	4	906	c.783G>T	c.(781-783)AAG>AAT	p.K261N	WNT11_uc001oxf.1_Missense_Mutation_p.K261N	NM_004626	NP_004617	O96014	WNT11_HUMAN	wingless-type MMTV integration site family,	261					adrenal gland development|anterior/posterior pattern formation|artery morphogenesis|axis specification|bone mineralization|cellular response to retinoic acid|cloacal septation|embryonic skeletal system development|endoderm development|lung-associated mesenchyme development|mesonephric duct development|negative regulation of apoptosis|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cartilage development|negative regulation of cell growth|negative regulation of cell migration|negative regulation of transcription, DNA-dependent|neuroendocrine cell differentiation|neuron differentiation|osteoblast differentiation|outflow tract morphogenesis|palate development|positive regulation of cell migration|positive regulation of protein kinase C signaling cascade|positive regulation of stress fiber assembly|positive regulation of transcription, DNA-dependent|positive regulation of transforming growth factor-beta2 production|protein localization at cell surface|protein phosphorylation|tight junction assembly|ureteric bud morphogenesis|ventricular septum morphogenesis|Wnt receptor signaling pathway, calcium modulating pathway	cytoplasm|extracellular space|plasma membrane|proteinaceous extracellular matrix	G-protein-coupled receptor binding|protein kinase activator activity|Ras GTPase activator activity|transcription regulatory region DNA binding			lung(1)|skin(1)	2						TATCCAGGTCCTTGGGCACCA	0.597			NA											33	138					4.4194e-11	5.5176e-11	0.013726	1	0
LRRC32	2615	broad.mit.edu	37	11	76372111	76372111	+	Nonsense_Mutation	SNP	C	C	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr11:76372111C>A	uc001oxq.3	-	3	769	c.526G>T	c.(526-528)GAG>TAG	p.E176*	LRRC32_uc001oxr.3_Nonsense_Mutation_p.E176*|LRRC32_uc010rsf.1_Nonsense_Mutation_p.E176*	NM_005512	NP_005503	Q14392	LRC32_HUMAN	leucine rich repeat containing 32 precursor	176	Extracellular (Potential).|LRR 6.					integral to plasma membrane					0						TCAAGCTGCTCCAGCGCAGGC	0.637			NA											15	65					1.00905e-13	1.30003e-13	0.008871	1	0
ODZ4	26011	broad.mit.edu	37	11	78412823	78412823	+	Missense_Mutation	SNP	T	T	C			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr11:78412823T>C	uc001ozl.3	-	28	5298	c.4835A>G	c.(4834-4836)TAC>TGC	p.Y1612C	ODZ4_uc009yvb.1_Missense_Mutation_p.Y196C	NM_001098816	NP_001092286	Q6N022	TEN4_HUMAN	odz, odd Oz/ten-m homolog 4	1612	Extracellular (Potential).|YD 2.				signal transduction	integral to membrane				ovary(2)|pancreas(2)	4						GTCCCCAGTGTAGGTGAAGTT	0.537			NA											30	115					0	0	0.008361	0	0
C11orf82	220042	broad.mit.edu	37	11	82643578	82643578	+	Missense_Mutation	SNP	G	G	C			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr11:82643578G>C	uc001ozt.2	+	6	1442	c.1198G>C	c.(1198-1200)GAG>CAG	p.E400Q	C11orf82_uc010rsr.1_Missense_Mutation_p.E99Q|C11orf82_uc010rss.1_Missense_Mutation_p.E99Q|C11orf82_uc009yvd.2_Intron	NM_145018	NP_659455	Q8IXT1	NOXIN_HUMAN	nitric oxide-inducible gene protein	400					apoptosis|cell cycle arrest	cytoplasm|nucleus				ovary(2)	2						CAGACTTGAAGAGACAGCCAG	0.463			NA											28	126					0	0	0.00632	0	0
NOX4	50507	broad.mit.edu	37	11	89184980	89184980	+	Silent	SNP	G	G	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr11:89184980G>A	uc001pct.2	-	3	476	c.237C>T	c.(235-237)CTC>CTT	p.L79L	NOX4_uc009yvr.2_Silent_p.L54L|NOX4_uc001pcu.2_Silent_p.L5L|NOX4_uc001pcw.2_Intron|NOX4_uc001pcx.2_Intron|NOX4_uc001pcv.2_Silent_p.L79L|NOX4_uc009yvo.2_RNA|NOX4_uc010rtu.1_Intron|NOX4_uc009yvp.2_Silent_p.L79L|NOX4_uc010rtv.1_Silent_p.L55L|NOX4_uc009yvq.2_Silent_p.L55L|NOX4_uc009yvs.1_RNA	NM_016931	NP_058627	Q9NPH5	NOX4_HUMAN	NADPH oxidase 4 isoform a	79	Ferric oxidoreductase.|Helical; (Potential).				cell aging|cell morphogenesis|inflammatory response|negative regulation of cell proliferation|superoxide anion generation	endoplasmic reticulum membrane|focal adhesion|integral to membrane|nucleus	electron carrier activity|flavin adenine dinucleotide binding|heme binding|NAD(P)H oxidase activity|nucleotide binding|oxygen sensor activity			ovary(1)|central_nervous_system(1)	2		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.011)				GGTAAGCCAAGAGTGTTCGGC	0.413			NA											6	44					0	0	0.001984	0	0
FAT3	120114	broad.mit.edu	37	11	92532943	92532943	+	Missense_Mutation	SNP	A	A	G			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr11:92532943A>G	uc001pdj.3	+	9	6781	c.6764A>G	c.(6763-6765)AAG>AGG	p.K2255R		NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	2255	Cadherin 20.|Extracellular (Potential).				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				TCTGCTTACAAGCTGACAATA	0.428			NA								TCGA Ovarian(4;0.039)			5	19					0	0	0.000602	0	0
MTNR1B	4544	broad.mit.edu	37	11	92714702	92714702	+	Missense_Mutation	SNP	G	G	C			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr11:92714702G>C	uc001pdk.1	+	2	416	c.313G>C	c.(313-315)GGC>CGC	p.G105R		NM_005959	NP_005950	P49286	MTR1B_HUMAN	melatonin receptor 1B	105	Extracellular (Potential).				G-protein signaling, coupled to cyclic nucleotide second messenger|glucose homeostasis|regulation of insulin secretion|synaptic transmission	integral to plasma membrane	melatonin receptor activity			ovary(1)|central_nervous_system(1)	2		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)			Ramelteon(DB00980)	CTTCTATGACGGCTGGGCCCT	0.572			NA											72	176					0	0	0.01441	0	0
MTNR1B	4544	broad.mit.edu	37	11	92715222	92715222	+	Missense_Mutation	SNP	C	C	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr11:92715222C>A	uc001pdk.1	+	2	936	c.833C>A	c.(832-834)CCC>CAC	p.P278H		NM_005959	NP_005950	P49286	MTR1B_HUMAN	melatonin receptor 1B	278	Extracellular (Potential).				G-protein signaling, coupled to cyclic nucleotide second messenger|glucose homeostasis|regulation of insulin secretion|synaptic transmission	integral to plasma membrane	melatonin receptor activity			ovary(1)|central_nervous_system(1)	2		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)			Ramelteon(DB00980)	GCCATCAACCCCCAAGAAATG	0.512			NA											62	157					9.10829e-22	1.23948e-21	0.01441	1	0
TRPC6	7225	broad.mit.edu	37	11	101375108	101375108	+	Missense_Mutation	SNP	G	G	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr11:101375108G>T	uc001pgk.3	-	2	1017	c.592C>A	c.(592-594)CAG>AAG	p.Q198K	TRPC6_uc009ywy.2_Missense_Mutation_p.Q198K|TRPC6_uc009ywz.1_Missense_Mutation_p.Q198K	NM_004621	NP_004612	Q9Y210	TRPC6_HUMAN	transient receptor potential cation channel,	198	Cytoplasmic (Potential).				axon guidance|platelet activation|positive regulation of calcium ion transport via store-operated calcium channel activity	integral to membrane|plasma membrane	protein binding			skin(2)|ovary(1)|central_nervous_system(1)	4		Acute lymphoblastic leukemia(157;0.000918)|all_hematologic(158;0.0162)		BRCA - Breast invasive adenocarcinoma(274;0.0442)		AGTTCAGACTGGCTAGGGCTG	0.468	Colon(166;1315 1927 11094 12848 34731)		NA											7	41					8.12818e-05	8.78788e-05	0.001984	1	0
DYNC2H1	79659	broad.mit.edu	37	11	103106399	103106399	+	Splice_Site	SNP	A	A	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr11:103106399A>T	uc001pho.2	+	62	9712	c.9568_splice	c.e62-2	p.V3190_splice	DYNC2H1_uc001phn.1_Splice_Site_p.V3190_splice|DYNC2H1_uc009yxe.1_Intron	NM_001080463	NP_001073932	Q8NCM8	DYHC2_HUMAN	dynein, cytoplasmic 2, heavy chain 1						cell projection organization|Golgi organization|microtubule-based movement|multicellular organismal development	cilium axoneme|dynein complex|Golgi apparatus|microtubule|plasma membrane	ATP binding|ATPase activity|microtubule motor activity				0		Acute lymphoblastic leukemia(157;0.000966)|all_hematologic(158;0.00348)		BRCA - Breast invasive adenocarcinoma(274;0.000177)|Epithelial(105;0.0785)		TCTTTTTTCCAGGTTGTAGAG	0.373			NA											4	5					0	0	0.009096	0	0
DDI1	414301	broad.mit.edu	37	11	103908684	103908684	+	Missense_Mutation	SNP	G	G	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr11:103908684G>T	uc001phr.2	+	1	1377	c.1134G>T	c.(1132-1134)GAG>GAT	p.E378D	PDGFD_uc001php.2_Intron|PDGFD_uc001phq.2_Intron	NM_001001711	NP_001001711	Q8WTU0	DDI1_HUMAN	DDI1, DNA-damage inducible 1, homolog 1	378					proteolysis		aspartic-type endopeptidase activity			large_intestine(3)|upper_aerodigestive_tract(1)|pancreas(1)	5		Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.00648)|Melanoma(852;0.055)|all_neural(303;0.164)		BRCA - Breast invasive adenocarcinoma(274;0.00128)|Epithelial(105;0.0631)|all cancers(92;0.169)		GGCAAGATGAGTCTTCGGACA	0.458			NA											5	31					1.23904e-05	1.37125e-05	0.000602	1	0
CUL5	8065	broad.mit.edu	37	11	107965125	107965125	+	Missense_Mutation	SNP	G	G	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr11:107965125G>A	uc001pjv.2	+	14	2118	c.1451G>A	c.(1450-1452)GGT>GAT	p.G484D	CUL5_uc001pju.2_RNA	NM_003478	NP_003469	Q93034	CUL5_HUMAN	Vasopressin-activated calcium-mobilizing	484					cell cycle arrest|cell proliferation|G1/S transition of mitotic cell cycle|induction of apoptosis by intracellular signals|interspecies interaction between organisms|negative regulation of cell proliferation|ubiquitin-dependent protein catabolic process|viral reproduction	cullin-RING ubiquitin ligase complex|cytosol	calcium channel activity|receptor activity|ubiquitin protein ligase binding			ovary(1)	1		all_cancers(61;7.09e-10)|all_epithelial(67;2.97e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|Melanoma(852;4.48e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		BRCA - Breast invasive adenocarcinoma(274;3.58e-05)|Epithelial(105;4.68e-05)|all cancers(92;0.00122)|OV - Ovarian serous cystadenocarcinoma(223;0.217)		TAGGAAGTTGGTATGCCAGCG	0.289			NA											4	30					0	0	0.000602	0	0
NCAM1	4684	broad.mit.edu	37	11	113103046	113103046	+	Missense_Mutation	SNP	C	C	G			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr11:113103046C>G	uc009yyq.1	+	12	1813	c.1119C>G	c.(1117-1119)ATC>ATG	p.I373M		NM_001076682	NP_001070150	P13591	NCAM1_HUMAN	neural cell adhesion molecule 1 isoform 3	465	Ig-like C2-type 5.|Extracellular (Potential).				axon guidance|interferon-gamma-mediated signaling pathway	anchored to membrane|extracellular region|Golgi membrane|integral to membrane				ovary(1)	1		all_cancers(61;5.82e-19)|all_epithelial(67;6.87e-12)|Melanoma(852;1.99e-05)|all_hematologic(158;3.66e-05)|Acute lymphoblastic leukemia(157;0.00119)|Breast(348;0.0109)|all_neural(223;0.0299)|Medulloblastoma(222;0.0458)|Renal(330;0.198)|Prostate(24;0.207)		BRCA - Breast invasive adenocarcinoma(274;1.78e-05)|Epithelial(105;0.000114)|all cancers(92;0.000467)|OV - Ovarian serous cystadenocarcinoma(223;0.212)		ATATCAAGATCTACAACACCC	0.527			NA											6	52					0	0	0.001984	0	0
DRD2	1813	broad.mit.edu	37	11	113286152	113286152	+	Silent	SNP	A	A	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr11:113286152A>T	uc001pnz.2	-	4	1035	c.714T>A	c.(712-714)GCT>GCA	p.A238A	DRD2_uc010rwv.1_Silent_p.A237A|DRD2_uc001poa.3_Silent_p.A238A|DRD2_uc001pob.3_Silent_p.A238A|DRD2_uc009yyr.1_Silent_p.A238A	NM_000795	NP_000786	P14416	DRD2_HUMAN	dopamine receptor D2 isoform long	238	Cytoplasmic (By similarity).|Interaction with PPP1R9B (By similarity).				activation of phospholipase C activity by dopamine receptor signaling pathway|adenohypophysis development|adult walking behavior|arachidonic acid secretion|axonogenesis|behavioral response to cocaine|behavioral response to ethanol|branching morphogenesis of a nerve|cerebral cortex GABAergic interneuron migration|circadian regulation of gene expression|elevation of cytosolic calcium ion concentration involved in G-protein signaling coupled to IP3 second messenger|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|intracellular protein kinase cascade|negative regulation of blood pressure|negative regulation of calcium ion transport via voltage-gated calcium channel activity|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of dopamine receptor signaling pathway|negative regulation of protein kinase B signaling cascade|negative regulation of protein secretion|negative regulation of synaptic transmission, glutamatergic|neurological system process involved in regulation of systemic arterial blood pressure|peristalsis|phosphatidylinositol metabolic process|positive regulation of dopamine uptake|positive regulation of growth hormone secretion|positive regulation of neuroblast proliferation|prepulse inhibition|protein localization|regulation of heart rate|regulation of long-term neuronal synaptic plasticity|regulation of potassium ion transport|regulation of sodium ion transport|regulation of synaptic transmission, GABAergic|release of sequestered calcium ion into cytosol|response to amphetamine|response to drug|response to histamine|response to morphine|sensory perception of smell|synapse assembly|temperature homeostasis|visual learning	integral to plasma membrane	dopamine D2 receptor activity|dopamine receptor activity, coupled via Gi/Go|drug binding|potassium channel regulator activity|protein binding			pancreas(1)|skin(1)	2		all_cancers(61;3.91e-16)|all_epithelial(67;2.95e-09)|Melanoma(852;1.46e-05)|all_hematologic(158;0.00014)|Acute lymphoblastic leukemia(157;0.000977)|Breast(348;0.0101)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)|Prostate(24;0.0494)		BRCA - Breast invasive adenocarcinoma(274;5.77e-06)|Epithelial(105;6.66e-05)|all cancers(92;0.000307)|OV - Ovarian serous cystadenocarcinoma(223;0.216)	Acetophenazine(DB01063)|Amantadine(DB00915)|Apomorphine(DB00714)|Aripiprazole(DB01238)|Bromocriptine(DB01200)|Buspirone(DB00490)|Cabergoline(DB00248)|Carphenazine(DB01038)|Chlorpromazine(DB00477)|Chlorprothixene(DB01239)|Cinnarizine(DB00568)|Clozapine(DB00363)|Domperidone(DB01184)|Droperidol(DB00450)|Ergotamine(DB00696)|Flupenthixol(DB00875)|Fluphenazine(DB00623)|Fluspirilene(DB04842)|Haloperidol(DB00502)|Levodopa(DB01235)|Lisuride(DB00589)|Loxapine(DB00408)|Mesoridazine(DB00933)|Metoclopramide(DB01233)|Minaprine(DB00805)|Molindone(DB01618)|Olanzapine(DB00334)|Paliperidone(DB01267)|Pergolide(DB01186)|Perphenazine(DB00850)|Pimozide(DB01100)|Pramipexole(DB00413)|Prochlorperazine(DB00433)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Quetiapine(DB01224)|Remoxipride(DB00409)|Risperidone(DB00734)|Ropinirole(DB00268)|Sertindole(DB06144)|Sulpiride(DB00391)|Thiethylperazine(DB00372)|Thioridazine(DB00679)|Tranylcypromine(DB00752)|Trifluoperazine(DB00831)|Triflupromazine(DB00508)|Ziprasidone(DB00246)|Zuclopenthixol(DB01624)	CCTTTAGTGGAGCCCTCAGGT	0.572			NA											27	117					0	0	0.00632	0	0
FAM55D	54827	broad.mit.edu	37	11	114453161	114453161	+	Missense_Mutation	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr11:114453161C>T	uc001ppc.2	-	3	860	c.679G>A	c.(679-681)GCT>ACT	p.A227T	FAM55D_uc001ppd.2_Intron	NM_001077639	NP_001071107	Q6UWF7	FA55D_HUMAN	hypothetical protein LOC54827 isoform 1	227						extracellular region				ovary(2)|skin(2)	4		all_cancers(61;8.53e-16)|all_epithelial(67;1.71e-08)|all_hematologic(158;3.05e-05)|Melanoma(852;0.000902)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0194)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)|Prostate(24;0.0906)		BRCA - Breast invasive adenocarcinoma(274;2.82e-06)|Epithelial(105;0.000129)|all cancers(92;0.000938)		CACAATTCAGCATTTGTGTTT	0.488			NA											4	45					0	0	0.000602	0	0
APOA5	116519	broad.mit.edu	37	11	116661394	116661394	+	Missense_Mutation	SNP	G	G	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr11:116661394G>T	uc001ppr.2	-	3	559	c.551C>A	c.(550-552)ACC>AAC	p.T184N	ZNF259_uc001ppp.2_5'Flank|ZNF259_uc009yzd.2_5'Flank|ZNF259_uc001ppq.2_5'Flank|APOA5_uc009yze.2_Missense_Mutation_p.T184N|APOA5_uc009yzf.2_Missense_Mutation_p.T184N|APOA5_uc009yzg.2_Missense_Mutation_p.T210N	NM_052968	NP_443200	Q6Q788	APOA5_HUMAN	apolipoprotein AV precursor	184					acylglycerol homeostasis|cholesterol homeostasis|lipid transport|lipoprotein metabolic process|positive regulation of fatty acid biosynthetic process|positive regulation of lipoprotein lipase activity|positive regulation of receptor-mediated endocytosis|positive regulation of triglyceride catabolic process|positive regulation of very-low-density lipoprotein particle remodeling|tissue regeneration|triglyceride catabolic process|triglyceride homeostasis	chylomicron|high-density lipoprotein particle|very-low-density lipoprotein particle	enzyme binding|heparin binding|lipoprotein lipase activator activity|low-density lipoprotein particle receptor binding|phosphatidylcholine binding				0	all_hematologic(175;0.0487)	all_cancers(61;3.31e-09)|all_epithelial(67;8.03e-06)|Breast(348;0.0126)|Melanoma(852;0.0153)|Acute lymphoblastic leukemia(157;0.0257)|Medulloblastoma(222;0.0425)|all_hematologic(158;0.0433)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|Epithelial(105;4.93e-06)|all cancers(92;0.000123)|OV - Ovarian serous cystadenocarcinoma(223;0.149)		GAAGCGGCCGGTGTGGTGCAC	0.682			NA											11	39					1.33987e-11	1.68295e-11	0.008291	1	0
APOA4	337	broad.mit.edu	37	11	116691596	116691596	+	Missense_Mutation	SNP	G	G	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr11:116691596G>A	uc001pps.1	-	3	1282	c.1178C>T	c.(1177-1179)CCT>CTT	p.P393L		NM_000482	NP_000473			apolipoprotein A-IV precursor												0	all_hematologic(175;0.0487)	Breast(348;0.0126)|Medulloblastoma(222;0.0425)|all_hematologic(158;0.0564)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;8.54e-06)|Epithelial(105;1.62e-05)|all cancers(92;0.000165)|OV - Ovarian serous cystadenocarcinoma(223;0.148)		GCTCTCCAAAGGGGCCAGCAT	0.483			NA											10	47					0	0	0.006214	0	0
DSCAML1	57453	broad.mit.edu	37	11	117395754	117395754	+	Missense_Mutation	SNP	G	G	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr11:117395754G>T	uc001prh.1	-	5	885	c.883C>A	c.(883-885)CAG>AAG	p.Q295K	DSCAML1_uc001pri.1_Missense_Mutation_p.Q99K	NM_020693	NP_065744	Q8TD84	DSCL1_HUMAN	Down syndrome cell adhesion molecule like 1	235	Ig-like C2-type 3.|Extracellular (Potential).				axonogenesis|brain development|cell fate determination|dorsal/ventral pattern formation|embryonic skeletal system morphogenesis|homophilic cell adhesion	cell surface|integral to membrane|plasma membrane	protein homodimerization activity			ovary(3)|large_intestine(2)|skin(2)|upper_aerodigestive_tract(1)	8	all_hematologic(175;0.0487)	Breast(348;0.0424)|Medulloblastoma(222;0.0523)|all_hematologic(192;0.232)		BRCA - Breast invasive adenocarcinoma(274;9.12e-06)|Epithelial(105;0.00172)		CACACTTCCTGGGAGTGGAAG	0.697			NA											5	15					0.000602214	0.000636401	0.000602	1	0
TREH	11181	broad.mit.edu	37	11	118532435	118532435	+	Missense_Mutation	SNP	G	G	C			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr11:118532435G>C	uc001pty.1	-	6	573	c.528C>G	c.(526-528)GAC>GAG	p.D176E	TREH_uc009zaj.1_Intron|TREH_uc001ptz.1_Missense_Mutation_p.D53E|TREH_uc009zak.2_Missense_Mutation_p.D176E	NM_007180	NP_009111	O43280	TREA_HUMAN	trehalase precursor	176					polysaccharide digestion|trehalose catabolic process	anchored to plasma membrane	alpha,alpha-trehalase activity			pancreas(1)	1	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0425)|all_hematologic(192;0.0564)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;3.16e-05)		CCCAGTAGGAGTCCCTGGGGA	0.632			NA											19	39					0	0	0.008871	0	0
CBL	867	broad.mit.edu	37	11	119170450	119170450	+	Nonsense_Mutation	SNP	G	G	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr11:119170450G>T	uc001pwe.2	+	16	2818	c.2680G>T	c.(2680-2682)GAA>TAA	p.E894*		NM_005188	NP_005179	P22681	CBL_HUMAN	Cas-Br-M (murine) ecotropic retroviral	894	Interaction with CD2AP.|UBA.				epidermal growth factor receptor signaling pathway|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of receptor-mediated endocytosis	cytosol|nucleus	calcium ion binding|sequence-specific DNA binding transcription factor activity|SH3 domain binding|signal transducer activity|ubiquitin-protein ligase activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(135)|lung(10)|central_nervous_system(2)|ovary(1)|breast(1)	149		Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;4.92e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.000784)		CATCCTCCGGGAATTTGTTTC	0.488			NA							CBL_gene-associated_Juvenile_Myelomonocytic_Leukemia_and_Developmental_Anomalies|Noonan_syndrome				126	202					9.77321e-77	1.38042e-76	0.01441	1	0
MFRP	83552	broad.mit.edu	37	11	119215663	119215663	+	Silent	SNP	G	G	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr11:119215663G>T	uc001pwj.2	-	6	853	c.693C>A	c.(691-693)CTC>CTA	p.L231L	MFRP_uc010rzf.1_RNA|MFRP_uc010rzg.1_Silent_p.L231L	NM_031433	NP_113621	Q9BXJ0	C1QT5_HUMAN	membrane frizzled-related protein	Error:Variant_position_missing_in_Q9BXJ0_after_alignment						collagen					0		Medulloblastoma(222;0.0523)|Breast(348;0.174)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;3.84e-05)		AGACCACCAGGAGGTGGCTGG	0.617			NA											5	14					1.23904e-05	1.37125e-05	0.000602	1	0
TBCEL	219899	broad.mit.edu	37	11	120916426	120916426	+	Silent	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr11:120916426C>T	uc009zay.2	+	2	105	c.27C>T	c.(25-27)TTC>TTT	p.F9F	TBCEL_uc001pxo.2_Silent_p.F9F|TBCEL_uc001pxp.2_5'UTR|TBCEL_uc001pxq.2_RNA	NM_001130047	NP_001123519	Q5QJ74	TBCEL_HUMAN	tubulin folding cofactor E-like	9						cytoplasm|cytoskeleton				skin(1)	1		Breast(109;0.00526)|Medulloblastoma(222;0.0523)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;5.89e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.121)		GAAGAAGTTTCATGCAAGTAT	0.363			NA											12	15					0	0	0.001855	0	0
ZNF202	7753	broad.mit.edu	37	11	123601254	123601254	+	Missense_Mutation	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr11:123601254C>T	uc001pzd.1	-	4	743	c.343G>A	c.(343-345)GAG>AAG	p.E115K	ZNF202_uc001pzc.1_5'UTR|ZNF202_uc001pze.1_Missense_Mutation_p.E115K|ZNF202_uc001pzf.1_Missense_Mutation_p.E115K	NM_003455	NP_003446	O95125	ZN202_HUMAN	zinc finger protein 202	115	SCAN box.				lipid metabolic process|negative regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1		Breast(109;0.00204)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;5.1e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.03)		ACTGCCTCCTCGCCACTTTCT	0.582			NA											42	94					0	0	0.009718	0	0
OR8B4	283162	broad.mit.edu	37	11	124294222	124294222	+	Silent	SNP	G	G	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr11:124294222G>T	uc010sak.1	-	1	546	c.546C>A	c.(544-546)CCC>CCA	p.P182P		NM_001005196	NP_001005196	Q96RC9	OR8B4_HUMAN	olfactory receptor, family 8, subfamily B,	182	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0279)		GCTGCAAGAGGGGGAGAACGT	0.507			NA											8	28					0.000157383	0.0001694	0.00308	1	0
APLP2	334	broad.mit.edu	37	11	129996686	129996686	+	Silent	SNP	G	G	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr11:129996686G>A	uc010sby.1	+	8	1339	c.1182G>A	c.(1180-1182)AAG>AAA	p.K394K	APLP2_uc001qfp.2_Silent_p.K394K|APLP2_uc001qfq.2_Silent_p.K338K|APLP2_uc010sbz.1_Silent_p.K182K|APLP2_uc001qfr.2_Silent_p.K160K|APLP2_uc001qfs.2_Silent_p.K165K|APLP2_uc001qfv.2_Silent_p.K285K	NM_001642	NP_001633	Q06481	APLP2_HUMAN	amyloid beta (A4) precursor-like protein 2	394	Extracellular (Potential).				G-protein coupled receptor protein signaling pathway	integral to membrane|nucleus|plasma membrane	DNA binding|identical protein binding|serine-type endopeptidase inhibitor activity			ovary(3)	3	all_hematologic(175;0.0429)	Breast(109;0.00586)|Lung NSC(97;0.00785)|all_lung(97;0.0154)|Medulloblastoma(222;0.0523)|all_neural(223;0.186)		OV - Ovarian serous cystadenocarcinoma(99;0.0197)|Lung(977;0.24)		AGAAGGCTAAGGAGCAGCTGG	0.468			NA											57	111					0	0	0.01441	0	0
WNK1	65125	broad.mit.edu	37	12	994187	994187	+	Missense_Mutation	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr12:994187C>T	uc001qio.3	+	19	4724	c.4217C>T	c.(4216-4218)TCA>TTA	p.S1406L	WNK1_uc001qip.3_Missense_Mutation_p.S1159L|WNK1_uc001qir.3_Missense_Mutation_p.S579L	NM_018979	NP_061852	Q9H4A3	WNK1_HUMAN	WNK lysine deficient protein kinase 1	1406					intracellular protein kinase cascade|ion transport|neuron development	cytoplasm	ATP binding|protein binding|protein kinase inhibitor activity|protein serine/threonine kinase activity			stomach(6)|breast(6)|ovary(5)|lung(4)|large_intestine(1)|central_nervous_system(1)	23	all_cancers(10;0.00611)|all_epithelial(11;0.00825)|all_lung(10;0.0331)|Ovarian(42;0.0512)|Lung NSC(10;0.0632)		Epithelial(1;1.74e-08)|all cancers(1;7.04e-08)|OV - Ovarian serous cystadenocarcinoma(31;0.000423)|BRCA - Breast invasive adenocarcinoma(9;0.0149)|Colorectal(1;0.0197)			GTGTCTGAATCACCAGTACTT	0.498	Colon(19;451 567 6672 12618 28860)		NA											21	60					0	0	0.010504	0	0
AKAP3	10566	broad.mit.edu	37	12	4747357	4747357	+	Silent	SNP	T	T	C			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr12:4747357T>C	uc001qnb.3	-	3	235	c.6A>G	c.(4-6)TCA>TCG	p.S2S		NM_006422	NP_006413	O75969	AKAP3_HUMAN	A-kinase anchor protein 3	2					acrosome reaction|cellular component movement	acrosomal vesicle	protein kinase A binding			skin(3)|large_intestine(1)|ovary(1)|kidney(1)	6						CAACCTTTTCTGACATCTGGA	0.428			NA											16	42					0	0	0.004007	0	0
GRIN2B	2904	broad.mit.edu	37	12	13717013	13717013	+	Missense_Mutation	SNP	G	G	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr12:13717013G>T	uc001rbt.2	-	13	3338	c.3159C>A	c.(3157-3159)GAC>GAA	p.D1053E		NM_000834	NP_000825	Q13224	NMDE2_HUMAN	N-methyl-D-aspartate receptor subunit 2B	1053	Cytoplasmic (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	glycine binding|N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			central_nervous_system(4)|ovary(3)|skin(3)|lung(2)	12					Felbamate(DB00949)|Haloperidol(DB00502)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	GGATCAAGTCGTCGTGGCCAC	0.572			NA											13	20					0.00010058	0.000108581	0.013537	1	0
GRIN2B	2904	broad.mit.edu	37	12	13717313	13717313	+	Silent	SNP	G	G	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr12:13717313G>T	uc001rbt.2	-	13	3038	c.2859C>A	c.(2857-2859)CCC>CCA	p.P953P		NM_000834	NP_000825	Q13224	NMDE2_HUMAN	N-methyl-D-aspartate receptor subunit 2B	953	Cytoplasmic (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	glycine binding|N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			central_nervous_system(4)|ovary(3)|skin(3)|lung(2)	12					Felbamate(DB00949)|Haloperidol(DB00502)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	TCTCCTCACAGGGCGGGTTGT	0.547			NA											23	63					3.5997e-14	4.67092e-14	0.014323	1	0
ABCC9	10060	broad.mit.edu	37	12	21981911	21981911	+	Missense_Mutation	SNP	C	C	G	rs12298510		TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr12:21981911C>G	uc001rfi.1	-	29	3670	c.3650G>C	c.(3649-3651)AGA>ACA	p.R1217T	ABCC9_uc001rfh.2_Missense_Mutation_p.R1217T|ABCC9_uc001rfj.1_Missense_Mutation_p.R1181T	NM_005691	NP_005682	O60706	ABCC9_HUMAN	ATP-binding cassette, sub-family C, member 9	1217	Extracellular (Potential).|ABC transmembrane type-1 2.				defense response to virus|potassium ion import	ATP-sensitive potassium channel complex	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium channel regulator activity|sulfonylurea receptor activity			ovary(4)|skin(2)	6					Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	CTCCAGCCATCTGTTGGCAGC	0.418			NA											11	38					0	0	0.013537	0	0
ABCC9	10060	broad.mit.edu	37	12	22068796	22068796	+	Missense_Mutation	SNP	G	G	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr12:22068796G>T	uc001rfi.1	-	5	642	c.622C>A	c.(622-624)CTC>ATC	p.L208I	ABCC9_uc001rfh.2_Missense_Mutation_p.L208I|ABCC9_uc001rfj.1_Missense_Mutation_p.L208I	NM_005691	NP_005682	O60706	ABCC9_HUMAN	ATP-binding cassette, sub-family C, member 9	208	Cytoplasmic (Potential).				defense response to virus|potassium ion import	ATP-sensitive potassium channel complex	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium channel regulator activity|sulfonylurea receptor activity			ovary(4)|skin(2)	6					Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	AGATCCTGGAGGTCTTCAGGA	0.363			NA											7	13					8.12818e-05	8.78788e-05	0.001984	1	0
ITPR2	3709	broad.mit.edu	37	12	26553192	26553192	+	Splice_Site	SNP	C	C	G			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr12:26553192C>G	uc001rhg.2	-	53	7817	c.7400_splice	c.e53-1	p.A2467_splice	ITPR2_uc009zjg.1_Splice_Site_p.A618_splice	NM_002223	NP_002214	Q14571	ITPR2_HUMAN	inositol 1,4,5-triphosphate receptor, type 2						activation of phospholipase C activity|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	integral to membrane|plasma membrane enriched fraction|platelet dense tubular network membrane|sarcoplasmic reticulum membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity			kidney(6)|ovary(4)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	14	Colorectal(261;0.0847)					TCTTCATCAGCTATAAAAACA	0.284			NA											10	27					0	0	0.006214	0	0
TMTC1	83857	broad.mit.edu	37	12	29786167	29786167	+	Missense_Mutation	SNP	C	C	A	rs139579223	by1000genomes	TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr12:29786167C>A	uc001rjb.2	-	6	1191	c.717G>T	c.(715-717)GAG>GAT	p.E239D	TMTC1_uc001riz.2_5'UTR|TMTC1_uc001rja.2_Missense_Mutation_p.E83D|TMTC1_uc001rjc.1_Missense_Mutation_p.E301D	NM_175861	NP_787057	Q8IUR5	TMTC1_HUMAN	transmembrane and tetratricopeptide repeat	347						integral to membrane	binding				0	Lung NSC(12;7.61e-10)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.032)					CCCATATGGTCTCTACCAGAG	0.507			NA											9	36					1.12685e-05	1.25378e-05	0.004482	1	0
CNTN1	1272	broad.mit.edu	37	12	41410526	41410526	+	Missense_Mutation	SNP	A	A	G			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr12:41410526A>G	uc001rmm.1	+	19	2340	c.2227A>G	c.(2227-2229)ATA>GTA	p.I743V	CNTN1_uc001rmn.1_Missense_Mutation_p.I732V	NM_001843	NP_001834	Q12860	CNTN1_HUMAN	contactin 1 isoform 1 precursor	743	Fibronectin type-III 2.				axon guidance|cell adhesion|Notch signaling pathway	anchored to membrane|membrane fraction|plasma membrane				lung(4)|ovary(3)|large_intestine(1)|skin(1)	9	all_cancers(12;2.07e-06)|all_epithelial(1;4.26e-06)|Breast(8;0.0716)	Lung NSC(34;0.0211)|all_lung(34;0.0294)				TTTTGGTTACATAGTGGCATT	0.363			NA											12	30					0	0	0.010729	0	0
NELL2	4753	broad.mit.edu	37	12	45004705	45004705	+	Nonsense_Mutation	SNP	A	A	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr12:45004705A>T	uc001rog.2	-	14	2088	c.1493T>A	c.(1492-1494)TTA>TAA	p.L498*	NELL2_uc001rof.3_Nonsense_Mutation_p.L497*|NELL2_uc001roh.2_Nonsense_Mutation_p.L498*|NELL2_uc009zkd.2_Nonsense_Mutation_p.L497*|NELL2_uc010skz.1_Nonsense_Mutation_p.L548*|NELL2_uc010sla.1_Nonsense_Mutation_p.L521*|NELL2_uc001roi.1_Nonsense_Mutation_p.L498*|NELL2_uc010slb.1_Nonsense_Mutation_p.L497*	NM_001145108	NP_001138580	Q99435	NELL2_HUMAN	NEL-like protein 2 isoform b precursor	498	EGF-like 3.				cell adhesion	extracellular region	calcium ion binding|protein binding|structural molecule activity			skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	4	Lung SC(27;0.192)	Lung NSC(34;0.144)		GBM - Glioblastoma multiforme(48;0.092)		GTTGAAGCATAAAGCATTTTC	0.388			NA											22	37					0	0	0.014323	0	0
DBX2	440097	broad.mit.edu	37	12	45410214	45410214	+	Missense_Mutation	SNP	C	C	G			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr12:45410214C>G	uc001rok.1	-	4	1047	c.875G>C	c.(874-876)AGG>ACG	p.R292T		NM_001004329	NP_001004329	Q6ZNG2	DBX2_HUMAN	developing brain homeobox 2	292						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0	Lung SC(27;0.192)	Lung NSC(34;0.142)		GBM - Glioblastoma multiforme(48;0.0515)		AGAATTCTCCCTCCATCTTGG	0.502			NA											13	48					0	0	0.013537	0	0
SFRS2IP	9169	broad.mit.edu	37	12	46321290	46321290	+	Missense_Mutation	SNP	C	C	G			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr12:46321290C>G	uc001rox.2	-	11	2481	c.2194G>C	c.(2194-2196)GAA>CAA	p.E732Q	SFRS2IP_uc001row.2_Missense_Mutation_p.E417Q|SFRS2IP_uc001roy.1_Missense_Mutation_p.E806Q	NM_004719	NP_004710	Q99590	SCAFB_HUMAN	splicing factor, arginine/serine-rich 2,	732					spliceosome assembly	nucleus	protein binding|zinc ion binding				0	Lung SC(27;0.192)|Renal(347;0.236)	Lung NSC(34;0.209)	OV - Ovarian serous cystadenocarcinoma(5;0.00691)	GBM - Glioblastoma multiforme(48;0.1)		GGTTCAACTTCAGATTCATTT	0.348			NA											5	69					0	0	0.001168	0	0
ASB8	140461	broad.mit.edu	37	12	48543473	48543473	+	Missense_Mutation	SNP	G	G	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr12:48543473G>T	uc001rrh.2	-	4	712	c.543C>A	c.(541-543)AAC>AAA	p.N181K	ASB8_uc010slr.1_Missense_Mutation_p.N177K	NM_024095	NP_077000	Q9H765	ASB8_HUMAN	ankyrin repeat and SOCS box-containing 8	181					intracellular signal transduction	cytoplasm|nucleus				kidney(1)	1						GGCCTATTAGGTTGATGACTC	0.522			NA											18	56					1.45105e-14	1.88793e-14	0.006122	1	0
WNT1	7471	broad.mit.edu	37	12	49373271	49373271	+	Missense_Mutation	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr12:49373271C>T	uc001rsu.2	+	2	323	c.125C>T	c.(124-126)TCC>TTC	p.S42F		NM_005430	NP_005421	P04628	WNT1_HUMAN	wingless-type MMTV integration site family,	42					brain segmentation|canonical Wnt receptor signaling pathway involved in negative regulation of apoptosis|central nervous system morphogenesis|cerebellum formation|dermatome development|diencephalon development|embryonic axis specification|forebrain anterior/posterior pattern formation|fourth ventricle development|hemopoietic stem cell proliferation|hepatocyte differentiation|inner ear morphogenesis|mesoderm morphogenesis|midbrain development|midbrain-hindbrain boundary maturation during brain development|negative regulation of cell-cell adhesion|negative regulation of cell-substrate adhesion|negative regulation of DNA damage checkpoint|negative regulation of fat cell differentiation|neuron fate determination|positive regulation of fibroblast proliferation|positive regulation of insulin-like growth factor receptor signaling pathway|positive regulation of lamellipodium assembly|positive regulation of Notch signaling pathway|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-dependent|response to wounding|signal transduction in response to DNA damage|Spemann organizer formation|T cell differentiation in thymus|Wnt receptor signaling pathway, calcium modulating pathway	early endosome|extracellular space|late endosome|membrane raft|plasma membrane|proteinaceous extracellular matrix	cytokine activity|frizzled-2 binding|transcription regulatory region DNA binding			kidney(1)	1				BRCA - Breast invasive adenocarcinoma(357;0.244)		AACGTAGCCTCCTCCACGAAC	0.552			NA											25	71					0	0	0.007291	0	0
MLL2	8085	broad.mit.edu	37	12	49435132	49435132	+	Missense_Mutation	SNP	C	C	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr12:49435132C>A	uc001rta.3	-	31	6421	c.6421G>T	c.(6421-6423)GGG>TGG	p.G2141W		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	2141	Pro-rich.				chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						TTCAGGAACCCGTCCGCAGAG	0.711			NA	N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			7	12					0.00198382	0.00206488	0.001984	1	0
NR4A1	3164	broad.mit.edu	37	12	52448768	52448768	+	Missense_Mutation	SNP	G	G	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr12:52448768G>T	uc001rzs.2	+	3	970	c.656G>T	c.(655-657)GGG>GTG	p.G219V	NR4A1_uc010sno.1_Missense_Mutation_p.G232V|NR4A1_uc001rzr.2_Missense_Mutation_p.G219V|NR4A1_uc009zmb.1_Missense_Mutation_p.G219V|NR4A1_uc001rzt.2_Missense_Mutation_p.G219V|NR4A1_uc009zmc.2_5'Flank	NM_002135	NP_002126	P22736	NR4A1_HUMAN	nuclear receptor subfamily 4, group A, member 1	219					nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor		steroid hormone receptor activity|zinc ion binding				0				BRCA - Breast invasive adenocarcinoma(357;0.0967)		CACCAGCTGGGGGAGGGAGAG	0.632			NA											82	159					3.80779e-57	5.36267e-57	0.01441	1	0
C12orf44	60673	broad.mit.edu	37	12	52467573	52467573	+	Missense_Mutation	SNP	A	A	G			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr12:52467573A>G	uc001rzu.3	+	3	614	c.139A>G	c.(139-141)ATT>GTT	p.I47V	C12orf44_uc009zmd.2_Missense_Mutation_p.I47V	NM_021934	NP_068753	Q9BSB4	ATGA1_HUMAN	Atg13-interacting protein	47				I -> T (in Ref. 1; BAB13907).	autophagic vacuole assembly	pre-autophagosomal structure	identical protein binding|protein complex binding				0				BRCA - Breast invasive adenocarcinoma(357;0.0978)		CACCTACTCCATTGGCACCGT	0.587			NA											18	34					0	0	0.00499	0	0
KRT82	3888	broad.mit.edu	37	12	52788852	52788853	+	Missense_Mutation	DNP	GG	GG	TT			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr12:52788852_52788853GG>TT	uc001sai.1	-	9	1563_1564	c.1448_1449CC>AA	c.(1447-1449)CCC>CAA	p.P483Q		NM_033033	NP_149022	Q9NSB4	KRT82_HUMAN	keratin 82	483	Tail.					keratin filament	protein binding|structural constituent of epidermis			ovary(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(357;0.193)		GGGGCTCGCAGGGGACATAGAG	0.634			NA											25	76					0	0	0.004672	0	0
KRT73	319101	broad.mit.edu	37	12	53010126	53010126	+	Silent	SNP	G	G	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr12:53010126G>A	uc001sas.2	-	2	521	c.486C>T	c.(484-486)ACC>ACT	p.T162T		NM_175068	NP_778238	Q86Y46	K2C73_HUMAN	keratin 73	162	Coil 1A.|Rod.					keratin filament	structural molecule activity			large_intestine(2)|ovary(2)|skin(2)	6				BRCA - Breast invasive adenocarcinoma(357;0.189)		GCTCCCACTTGGTCTCCAGCA	0.552			NA											18	78					0	0	0.00499	0	0
KRT2	3849	broad.mit.edu	37	12	53042001	53042001	+	Missense_Mutation	SNP	C	C	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr12:53042001C>A	uc001sat.2	-	5	1111	c.1078G>T	c.(1078-1080)GCC>TCC	p.A360S		NM_000423	NP_000414	P35908	K22E_HUMAN	keratin 2	360	Coil 2.|Rod.				keratinization|keratinocyte activation|keratinocyte migration|keratinocyte proliferation	Golgi apparatus|keratin filament	protein binding|structural constituent of cytoskeleton			ovary(2)	2				BRCA - Breast invasive adenocarcinoma(357;0.19)		CTCCTCTGGGCGATCTCCTCA	0.572			NA											44	87					6.21074e-16	8.19073e-16	0.011902	1	0
KRT2	3849	broad.mit.edu	37	12	53045355	53045355	+	Missense_Mutation	SNP	G	G	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr12:53045355G>A	uc001sat.2	-	1	605	c.572C>T	c.(571-573)TCC>TTC	p.S191F		NM_000423	NP_000414	P35908	K22E_HUMAN	keratin 2	191	Coil 1A.|Rod.				keratinization|keratinocyte activation|keratinocyte migration|keratinocyte proliferation	Golgi apparatus|keratin filament	protein binding|structural constituent of cytoskeleton			ovary(2)	2				BRCA - Breast invasive adenocarcinoma(357;0.19)		GTCAATGAAGGAGGCAAATTT	0.483			NA											12	48					0	0	0.010729	0	0
KRT8	3856	broad.mit.edu	37	12	53291304	53291304	+	Missense_Mutation	SNP	G	G	C			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr12:53291304G>C	uc001sbd.2	-	8	1463	c.1360C>G	c.(1360-1362)CGC>GGC	p.R454G	KRT8_uc009zmj.2_3'UTR|KRT8_uc009zmk.1_Missense_Mutation_p.R482G|KRT8_uc009zml.1_Missense_Mutation_p.R454G|KRT8_uc009zmm.1_Missense_Mutation_p.R454G	NM_002273	NP_002264	P05787	K2C8_HUMAN	keratin 8	454	Tail.				cytoskeleton organization|interspecies interaction between organisms	cytoplasm|keratin filament|nuclear matrix|nucleoplasm	protein binding|structural molecule activity			ovary(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(357;0.108)	Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GAGCTGGTGCGGCTGAAggag	0.423			NA											9	86					0	0	0.006214	0	0
TENC1	23371	broad.mit.edu	37	12	53451395	53451395	+	Missense_Mutation	SNP	T	T	C			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr12:53451395T>C	uc001sbp.2	+	12	1025	c.890T>C	c.(889-891)ATG>ACG	p.M297T	TENC1_uc001sbl.2_Missense_Mutation_p.M173T|TENC1_uc001sbn.2_Missense_Mutation_p.M307T|TENC1_uc001sbo.1_Missense_Mutation_p.M297T|TENC1_uc001sbq.2_5'Flank|TENC1_uc001sbr.2_5'Flank|TENC1_uc009zmr.2_5'Flank	NM_170754	NP_736610	Q63HR2	TENC1_HUMAN	tensin like C1 domain containing phosphatase	297					intracellular signal transduction|negative regulation of cell proliferation	focal adhesion	metal ion binding|phosphoprotein phosphatase activity|protein binding			ovary(1)|pancreas(1)	2						TCCATCAGAATGAACAGCAGC	0.537			NA											221	193					0	0	0.01441	0	0
HOXC13	3229	broad.mit.edu	37	12	54338891	54338891	+	Missense_Mutation	SNP	A	A	G			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr12:54338891A>G	uc001sei.2	+	2	959	c.844A>G	c.(844-846)AGC>GGC	p.S282G	HOXC13_uc010sop.1_RNA	NM_017410	NP_059106	P31276	HXC13_HUMAN	homeobox C13	282	Homeobox.					nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)	1						ATACGCGGCTAGCAAGTTCAT	0.607			NA	T	NUP98	AML								29	119					0	0	0.007291	0	0
HNRNPA1	3178	broad.mit.edu	37	12	54675174	54675174	+	Missense_Mutation	SNP	C	C	G			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr12:54675174C>G	uc001sfl.2	+	2	124	c.20C>G	c.(19-21)CCT>CGT	p.P7R	CBX5_uc001sfk.3_5'Flank|CBX5_uc001sfi.3_5'Flank|HNRNPA1_uc001sfm.2_Missense_Mutation_p.P7R|HNRNPA1_uc009zng.2_Missense_Mutation_p.P7R|HNRNPA1_uc009znh.2_Missense_Mutation_p.P7R|HNRNPA1_uc009zni.2_Missense_Mutation_p.P7R|HNRNPA1_uc001sfn.2_Missense_Mutation_p.P7R|HNRNPA1_uc001sfo.3_RNA|HNRNPA1_uc001sfp.1_5'UTR|HNRNPA1_uc009znj.1_5'Flank	NM_031157	NP_112420	P09651	ROA1_HUMAN	heterogeneous nuclear ribonucleoprotein A1	7	Globular A domain.				interspecies interaction between organisms|mRNA transport|nuclear import	catalytic step 2 spliceosome|cytoplasm|heterogeneous nuclear ribonucleoprotein complex|nucleolus|nucleoplasm	nucleotide binding|protein binding|single-stranded DNA binding			skin(2)|ovary(1)	3						CTCTAGTCTCCTAAAGAGCCC	0.483	Colon(83;502 1289 8436 16406 24870)		NA											24	44					0	0	0.00333	0	0
NCKAP1L	3071	broad.mit.edu	37	12	54912725	54912725	+	Missense_Mutation	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr12:54912725C>T	uc001sgc.3	+	15	1527	c.1448C>T	c.(1447-1449)TCA>TTA	p.S483L	NCKAP1L_uc010sox.1_Missense_Mutation_p.S25L|NCKAP1L_uc010soy.1_Missense_Mutation_p.S433L	NM_005337	NP_005328	P55160	NCKPL_HUMAN	NCK-associated protein 1-like	483					actin polymerization-dependent cell motility|B cell homeostasis|B cell receptor signaling pathway|cortical actin cytoskeleton organization|erythrocyte development|maintenance of cell polarity|myeloid cell homeostasis|negative regulation of apoptosis|negative regulation of interleukin-17 production|negative regulation of interleukin-6 production|negative regulation of myosin-light-chain-phosphatase activity|neutrophil chemotaxis|positive regulation of actin filament polymerization|positive regulation of B cell differentiation|positive regulation of B cell proliferation|positive regulation of CD4-positive, alpha-beta T cell differentiation|positive regulation of CD8-positive, alpha-beta T cell differentiation|positive regulation of cell adhesion mediated by integrin|positive regulation of erythrocyte differentiation|positive regulation of gamma-delta T cell differentiation|positive regulation of neutrophil chemotaxis|positive regulation of phagocytosis, engulfment|positive regulation of T cell proliferation|protein complex assembly|response to drug|T cell homeostasis	cytosol|integral to plasma membrane|membrane fraction|SCAR complex	protein complex binding|protein kinase activator activity|Rac GTPase activator activity			ovary(3)|central_nervous_system(1)	4						TTTGAATTCTCAGGATTGAGG	0.388			NA											7	38					0	0	0.004482	0	0
OR9K2	441639	broad.mit.edu	37	12	55523797	55523797	+	Missense_Mutation	SNP	C	C	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr12:55523797C>A	uc010spe.1	+	1	245	c.245C>A	c.(244-246)ACA>AAA	p.T82K		NM_001005243	NP_001005243	Q8NGE7	OR9K2_HUMAN	olfactory receptor, family 9, subfamily K,	82	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|pancreas(1)	2						CGGCTGAACACACCAATGTAT	0.388			NA											30	86					5.60225e-13	7.14804e-13	0.009535	1	0
OR6C2	341416	broad.mit.edu	37	12	55846499	55846499	+	Missense_Mutation	SNP	G	G	C			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr12:55846499G>C	uc001sgz.1	+	1	502	c.502G>C	c.(502-504)GAC>CAC	p.D168H		NM_054105	NP_473446	Q9NZP2	OR6C2_HUMAN	olfactory receptor, family 6, subfamily C,	168	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2						CGAATTCTGTGACTCCAATGC	0.448			NA											15	28					0	0	0.003163	0	0
SUOX	6821	broad.mit.edu	37	12	56397693	56397693	+	Missense_Mutation	SNP	G	G	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr12:56397693G>A	uc001six.2	+	6	846	c.520G>A	c.(520-522)GAC>AAC	p.D174N	SUOX_uc001siy.2_Missense_Mutation_p.D174N|SUOX_uc001siz.2_Missense_Mutation_p.D174N|SUOX_uc001sja.2_Missense_Mutation_p.D174N	NM_000456	NP_000447	P51687	SUOX_HUMAN	sulfite oxidase precursor	174	Hinge (By similarity).					mitochondrial intermembrane space	electron carrier activity|molybdenum ion binding|sulfite oxidase activity				0			UCEC - Uterine corpus endometrioid carcinoma (6;0.0471)|OV - Ovarian serous cystadenocarcinoma(18;0.119)			GGAGACCTCTGACCCTTATGC	0.547			NA											8	61					0	0	0.00308	0	0
OBFC2B	79035	broad.mit.edu	37	12	56619478	56619478	+	Missense_Mutation	SNP	G	G	C			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr12:56619478G>C	uc001ski.2	+	4	413	c.289G>C	c.(289-291)GAA>CAA	p.E97Q	OBFC2B_uc001skk.2_Missense_Mutation_p.E122Q|OBFC2B_uc001skj.2_Missense_Mutation_p.E113Q	NM_024068	NP_076973	Q9BQ15	SOSB1_HUMAN	oligonucleotide/oligosaccharide-binding fold	97					double-strand break repair via homologous recombination|G2/M transition checkpoint|response to ionizing radiation	SOSS complex	protein binding|single-stranded DNA binding			ovary(1)	1						GAAGATTGGAGAGTAAGTGCT	0.488			NA						Direct_reversal_of_damage|Other_identified_genes_with_known_or_suspected_DNA_repair_function					20	110					0	0	0.014323	0	0
ANKRD52	283373	broad.mit.edu	37	12	56647906	56647906	+	Missense_Mutation	SNP	T	T	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr12:56647906T>A	uc001skm.3	-	8	941	c.851A>T	c.(850-852)AAT>ATT	p.N284I	ANKRD52_uc001skn.1_RNA	NM_173595	NP_775866	Q8NB46	ANR52_HUMAN	ankyrin repeat domain 52	284	ANK 9.						protein binding			ovary(2)	2						GAGAGCGCCATTGGTGGAGAC	0.552			NA											15	82					0	0	0.003163	0	0
RDH16	8608	broad.mit.edu	37	12	57346020	57346020	+	Silent	SNP	T	T	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr12:57346020T>A	uc001smi.3	-	4	919	c.747A>T	c.(745-747)TCA>TCT	p.S249S	RDH16_uc009zpa.2_Silent_p.S104S	NM_003708	NP_003699	O75452	RDH16_HUMAN	retinol dehydrogenase 16	249	Cytoplasmic (Potential).				lipid metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	binding|electron carrier activity|retinol dehydrogenase activity				0						TTTGTTCAGCTGATTTCTTAT	0.468	GBM(179;741 2921 43105 45298)		NA											13	27					0	0	0.013537	0	0
AVPR1A	552	broad.mit.edu	37	12	63543950	63543950	+	Missense_Mutation	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr12:63543950C>T	uc001sro.1	-	1	2641	c.667G>A	c.(667-669)GGC>AGC	p.G223S		NM_000706	NP_000697	P37288	V1AR_HUMAN	arginine vasopressin receptor 1A	223	Helical; Name=5; (Potential).				activation of phospholipase C activity|elevation of cytosolic calcium ion concentration|generation of precursor metabolites and energy	endosome|integral to plasma membrane	protein kinase C binding|vasopressin receptor activity				0			BRCA - Breast invasive adenocarcinoma(9;0.193)	GBM - Glioblastoma multiforme(28;0.0569)	Conivaptan(DB00872)|Desmopressin(DB00035)|Felypressin(DB00093)|Terlipressin(DB02638)|Vasopressin(DB00067)	ACAAAGATGCCGCCCGTCATC	0.617			NA											25	135					0	0	0.003954	0	0
SRGAP1	57522	broad.mit.edu	37	12	64536211	64536211	+	Missense_Mutation	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr12:64536211C>T	uc010ssp.1	+	22	3073	c.3017C>T	c.(3016-3018)ACG>ATG	p.T1006M	SRGAP1_uc001srv.2_Missense_Mutation_p.T943M	NM_020762	NP_065813	Q7Z6B7	SRGP1_HUMAN	SLIT-ROBO Rho GTPase activating protein 1	1006					axon guidance	cytosol				ovary(2)|central_nervous_system(2)	4			GBM - Glioblastoma multiforme(3;0.000139)|BRCA - Breast invasive adenocarcinoma(9;0.225)	GBM - Glioblastoma multiforme(28;0.0608)		GCCACTTCCACGGAATCTCTC	0.552			NA											18	37					0	0	0.00499	0	0
PTPRR	5801	broad.mit.edu	37	12	71094993	71094993	+	Missense_Mutation	SNP	G	G	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr12:71094993G>A	uc001swi.1	-	7	1534	c.1118C>T	c.(1117-1119)TCA>TTA	p.S373L	PTPRR_uc001swh.1_Missense_Mutation_p.S128L|PTPRR_uc009zrs.2_Missense_Mutation_p.S222L|PTPRR_uc010stq.1_Missense_Mutation_p.S261L|PTPRR_uc010str.1_Missense_Mutation_p.S222L	NM_002849	NP_002840	Q15256	PTPRR_HUMAN	protein tyrosine phosphatase, receptor type, R	373	Cytoplasmic (Potential).				in utero embryonic development	cell surface|Golgi apparatus|integral to membrane|nucleus|perinuclear region of cytoplasm|plasma membrane	protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			skin(2)|ovary(1)	3			GBM - Glioblastoma multiforme(2;5.67e-07)|Lung(24;0.00283)|OV - Ovarian serous cystadenocarcinoma(12;0.00578)|LUSC - Lung squamous cell carcinoma(43;0.132)	COAD - Colon adenocarcinoma(1;0.136)		TCGGCTGGCTGACTGCAGATA	0.458			NA											10	46					0	0	0.006214	0	0
LGR5	8549	broad.mit.edu	37	12	71977541	71977541	+	Missense_Mutation	SNP	G	G	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr12:71977541G>A	uc001swl.2	+	18	1799	c.1751G>A	c.(1750-1752)AGA>AAA	p.R584K	LGR5_uc001swm.2_Missense_Mutation_p.R560K|LGR5_uc001swn.1_RNA	NM_003667	NP_003658	O75473	LGR5_HUMAN	leucine-rich repeat-containing G protein-coupled	584	Cytoplasmic (Potential).					integral to plasma membrane	protein-hormone receptor activity			lung(4)|skin(3)|ovary(1)|pancreas(1)	9						ACAGTTTTCAGATCCCCTCTG	0.493			NA											22	104					0	0	0.012319	0	0
TRHDE	29953	broad.mit.edu	37	12	72680629	72680629	+	Missense_Mutation	SNP	G	G	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr12:72680629G>T	uc001sxa.2	+	2	978	c.948G>T	c.(946-948)TGG>TGT	p.W316C		NM_013381	NP_037513	Q9UKU6	TRHDE_HUMAN	thyrotropin-releasing hormone degrading enzyme	316	Extracellular (Potential).				cell-cell signaling|proteolysis|signal transduction	integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|zinc ion binding			ovary(2)|skin(1)	3						AAGATGGATGGGTTACGGATC	0.418			NA											30	56					3.65163e-15	4.77672e-15	0.00632	1	0
NAV3	89795	broad.mit.edu	37	12	78400307	78400307	+	Missense_Mutation	SNP	A	A	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr12:78400307A>T	uc001syp.2	+	8	1162	c.989A>T	c.(988-990)AAG>ATG	p.K330M	NAV3_uc001syo.2_Missense_Mutation_p.K330M	NM_014903	NP_055718	Q8IVL0	NAV3_HUMAN	neuron navigator 3	330						nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			large_intestine(6)|ovary(5)|lung(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	17						AGTGCCAGCAAGCCCTGGCGC	0.547			NA								HNSCC(70;0.22)			19	40					0	0	0.007413	0	0
NAV3	89795	broad.mit.edu	37	12	78574751	78574751	+	Missense_Mutation	SNP	C	C	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr12:78574751C>A	uc001syp.2	+	30	5791	c.5618C>A	c.(5617-5619)ACC>AAC	p.T1873N	NAV3_uc001syo.2_Missense_Mutation_p.T1851N|NAV3_uc010sub.1_Missense_Mutation_p.T1330N|NAV3_uc009zsf.2_Missense_Mutation_p.T682N	NM_014903	NP_055718	Q8IVL0	NAV3_HUMAN	neuron navigator 3	1873	Ser-rich.					nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			large_intestine(6)|ovary(5)|lung(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	17						TCAAGCAGCACCTCCTCTTCA	0.448			NA								HNSCC(70;0.22)			7	19					0.00198382	0.00206488	0.001984	1	0
SLC6A15	55117	broad.mit.edu	37	12	85285753	85285754	+	Missense_Mutation	DNP	TG	TG	CT			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	TG	TG	-	-	TG	TG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr12:85285753_85285754TG>CT	uc001szv.2	-	2	639_640	c.146_147CA>AG	c.(145-147)ACA>AAG	p.T49K	SLC6A15_uc010sul.1_Intron|SLC6A15_uc001szy.2_Missense_Mutation_p.T49K	NM_182767	NP_877499	Q9H2J7	S6A15_HUMAN	solute carrier family 6, member 15 isoform 1	49	Cytoplasmic (Potential).				cellular nitrogen compound metabolic process|leucine transport|proline transport	integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity			pancreas(2)|ovary(1)	3						CTTCAACATCTGTATCTTTCTC	0.406			NA											7	74					0	0	0.004672	0	0
TMTC3	160418	broad.mit.edu	37	12	88588674	88588674	+	Missense_Mutation	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr12:88588674C>T	uc001tau.2	+	14	2213	c.1993C>T	c.(1993-1995)CCA>TCA	p.P665S		NM_181783	NP_861448	Q6ZXV5	TMTC3_HUMAN	transmembrane and tetratricopeptide repeat	666						integral to membrane	binding			skin(1)	1						AAATGAAGAGCCACTAGATGC	0.313			NA											3	22					0	0	0.004672	0	0
GALNT4	8693	broad.mit.edu	37	12	89916936	89916936	+	Missense_Mutation	SNP	T	T	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr12:89916936T>A	uc001tbd.2	-	1	1600	c.1391A>T	c.(1390-1392)GAC>GTC	p.D464V	POC1B_uc001tba.2_Intron|POC1B_uc001tbb.2_Intron|POC1B_uc001tbc.2_Intron|POC1B_uc010sun.1_Intron|GALNT4_uc001tbe.2_Missense_Mutation_p.D461V|GALNT4_uc010suo.1_Missense_Mutation_p.D156V	NM_003774	NP_003765	Q8N4A0	GALT4_HUMAN	polypeptide N-acetylgalactosaminyltransferase 4	464	Ricin B-type lectin.|Lumenal (Potential).				carbohydrate metabolic process	Golgi membrane|integral to membrane|perinuclear region of cytoplasm	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding				0						GGGGTTGTTGTCAGGAGAATT	0.403			NA											11	43					0	0	0.008291	0	0
PLEKHG7	440107	broad.mit.edu	37	12	93163941	93163941	+	Silent	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr12:93163941C>T	uc001tcj.2	+	12	1340	c.1110C>T	c.(1108-1110)TTC>TTT	p.F370F		NM_001004330	NP_001004330	Q6ZR37	PKHG7_HUMAN	pleckstrin homology domain containing, family G	370					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			ovary(1)	1						TATCTTTATTCACATTGCCCG	0.318			NA											5	23					0	0	0.000602	0	0
NR1H4	9971	broad.mit.edu	37	12	100934574	100934574	+	Silent	SNP	G	G	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr12:100934574G>A	uc001tht.1	+	7	1114	c.1086G>A	c.(1084-1086)TTG>TTA	p.L362L	NR1H4_uc001thp.1_Silent_p.L348L|NR1H4_uc001thq.1_Silent_p.L352L|NR1H4_uc010svj.1_RNA|NR1H4_uc001thr.1_Silent_p.L352L|NR1H4_uc010svk.1_Silent_p.L301L|NR1H4_uc001ths.1_Silent_p.L358L	NM_005123	NP_005114	Q96RI1	NR1H4_HUMAN	nuclear receptor subfamily 1, group H, member 4	362	Ligand-binding.				bile acid metabolic process|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|thyroid hormone receptor activity|transcription coactivator activity|transcription corepressor activity|zinc ion binding			ovary(1)|lung(1)|skin(1)	3						CTGACCTATTGGAAGAAAGAA	0.333			NA											14	33					0	0	0.001855	0	0
NR1H4	9971	broad.mit.edu	37	12	100957082	100957082	+	Missense_Mutation	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr12:100957082C>T	uc001tht.1	+	9	1304	c.1276C>T	c.(1276-1278)CTT>TTT	p.L426F	NR1H4_uc001thp.1_Missense_Mutation_p.L412F|NR1H4_uc001thq.1_Missense_Mutation_p.L416F|NR1H4_uc010svj.1_RNA|NR1H4_uc001thr.1_Missense_Mutation_p.L416F|NR1H4_uc010svk.1_Missense_Mutation_p.L365F|NR1H4_uc001ths.1_Missense_Mutation_p.L422F	NM_005123	NP_005114	Q96RI1	NR1H4_HUMAN	nuclear receptor subfamily 1, group H, member 4	426	Ligand-binding.				bile acid metabolic process|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|thyroid hormone receptor activity|transcription coactivator activity|transcription corepressor activity|zinc ion binding			ovary(1)|lung(1)|skin(1)	3						GGAGCCACTTCTTGATGTGCT	0.383			NA											19	23					0	0	0.007413	0	0
GAS2L3	283431	broad.mit.edu	37	12	101018004	101018004	+	Missense_Mutation	SNP	T	T	C			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr12:101018004T>C	uc001thu.2	+	10	1647	c.1421T>C	c.(1420-1422)TTG>TCG	p.L474S	GAS2L3_uc009zty.2_Missense_Mutation_p.L474S|GAS2L3_uc001thv.2_Missense_Mutation_p.L370S	NM_174942	NP_777602	Q86XJ1	GA2L3_HUMAN	growth arrest-specific 2 like 3	474					cell cycle arrest					skin(1)	1						CCTAAGTATTTGAAACATAAT	0.403			NA											5	38					0	0	0.000602	0	0
HSP90B1	7184	broad.mit.edu	37	12	104340715	104340715	+	Missense_Mutation	SNP	C	C	G			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr12:104340715C>G	uc001tkb.1	+	16	2363	c.2258C>G	c.(2257-2259)GCA>GGA	p.A753G	HSP90B1_uc010swg.1_Missense_Mutation_p.A418G|HSP90B1_uc009zui.1_Intron	NM_003299	NP_003290	P14625	ENPL_HUMAN	heat shock protein 90kDa beta, member 1	753					actin rod assembly|anti-apoptosis|cellular response to ATP|ER-associated protein catabolic process|protein folding|protein transport|regulation of phosphoprotein phosphatase activity|response to hypoxia|sequestering of calcium ion	cytosol|endoplasmic reticulum lumen|endoplasmic reticulum membrane|melanosome|microsome|midbody|perinuclear region of cytoplasm	ATP binding|calcium ion binding|low-density lipoprotein particle receptor binding|protein phosphatase binding|RNA binding|unfolded protein binding|virion binding			ovary(2)|skin(1)	3					Rifabutin(DB00615)	GACCCTGATGCAAAGGTTTGT	0.453			NA											5	25					0	0	0.001168	0	0
CHST11	50515	broad.mit.edu	37	12	105150924	105150924	+	Silent	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr12:105150924C>T	uc001tkx.1	+	4	693	c.402C>T	c.(400-402)CTC>CTT	p.L134L	CHST11_uc001tky.2_Silent_p.L129L|uc001tkz.2_5'Flank	NM_018413	NP_060883	Q9NPF2	CHSTB_HUMAN	carbohydrate sulfotransferase 11	134	Lumenal (Potential).				chondroitin sulfate biosynthetic process	Golgi membrane|integral to membrane	chondroitin 4-sulfotransferase activity|N-acetylgalactosamine 4-O-sulfotransferase activity				0						GGAAGCGGCTCATGATGGTCC	0.612			NA											6	68					0	0	0.001168	0	0
KIAA1033	23325	broad.mit.edu	37	12	105515907	105515907	+	Missense_Mutation	SNP	C	C	G			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr12:105515907C>G	uc001tld.2	+	10	764	c.677C>G	c.(676-678)TCT>TGT	p.S226C	KIAA1033_uc010swr.1_Missense_Mutation_p.S226C|KIAA1033_uc010sws.1_Missense_Mutation_p.S38C	NM_015275	NP_056090	Q2M389	WAHS7_HUMAN	hypothetical protein LOC23325	226					endosome transport	WASH complex				kidney(1)|central_nervous_system(1)	2						TTACTGAAATCTGTCCATCAC	0.284			NA											11	19					0	0	0.008291	0	0
POLR3B	55703	broad.mit.edu	37	12	106848433	106848433	+	Missense_Mutation	SNP	A	A	G			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr12:106848433A>G	uc001tlp.2	+	20	2459	c.2237A>G	c.(2236-2238)TAT>TGT	p.Y746C	POLR3B_uc001tlq.2_Missense_Mutation_p.Y688C	NM_018082	NP_060552	Q9NW08	RPC2_HUMAN	DNA-directed RNA polymerase III B isoform 1	746					innate immune response|positive regulation of innate immune response|positive regulation of interferon-beta production|response to virus|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase III promoter	nucleoplasm	DNA binding|DNA-directed RNA polymerase activity|metal ion binding|ribonucleoside binding			ovary(1)|central_nervous_system(1)	2						GTGATGAGCTATAGTGGCTAT	0.373			NA											9	18					0	0	0.006214	0	0
PRDM4	11108	broad.mit.edu	37	12	108134944	108134944	+	Missense_Mutation	SNP	T	T	C			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr12:108134944T>C	uc001tmp.2	-	10	2140	c.1703A>G	c.(1702-1704)CAT>CGT	p.H568R	PRDM4_uc010sww.1_5'UTR|PRDM4_uc001tmq.2_RNA	NM_012406	NP_036538	Q9UKN5	PRDM4_HUMAN	PR domain containing 4	568					cell proliferation|negative regulation of cell cycle|nerve growth factor receptor signaling pathway|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleus	DNA binding|zinc ion binding			breast(1)|skin(1)	2						AAGATGGTTATGGATGTGGCT	0.488			NA											15	85					0	0	0.004007	0	0
CORO1C	23603	broad.mit.edu	37	12	109055932	109055932	+	Silent	SNP	T	T	C			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr12:109055932T>C	uc001tnj.2	-	4	417	c.321A>G	c.(319-321)GTA>GTG	p.V107V	CORO1C_uc009zva.2_Silent_p.V160V|CORO1C_uc010sxf.1_Silent_p.V107V	NM_014325	NP_055140	Q9ULV4	COR1C_HUMAN	coronin, actin binding protein, 1C isoform 1	107	WD 1.				actin cytoskeleton organization|phagocytosis|signal transduction	actin cytoskeleton	actin filament binding			skin(3)	3						GGATCTGCCATACCTGTTGGA	0.438			NA											10	20					0	0	0.006214	0	0
PPTC7	160760	broad.mit.edu	37	12	110977723	110977723	+	Silent	SNP	G	G	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr12:110977723G>A	uc001trh.1	-	4	858	c.630C>T	c.(628-630)TTC>TTT	p.F210F		NM_139283	NP_644812	Q8NI37	PPTC7_HUMAN	T-cell activation protein phosphatase 2C	210	PP2C-like.						metal ion binding|phosphoprotein phosphatase activity				0						GCTGGACATCGAAAGACGTGC	0.453			NA											3	31					0	0	0.004672	0	0
RBM19	9904	broad.mit.edu	37	12	114384250	114384250	+	Missense_Mutation	SNP	T	T	C			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr12:114384250T>C	uc009zwi.2	-	12	1582	c.1438A>G	c.(1438-1440)ATC>GTC	p.I480V	RBM19_uc001tvn.3_Missense_Mutation_p.I480V|RBM19_uc001tvm.2_Missense_Mutation_p.I480V	NM_001146699	NP_001140171	Q9Y4C8	RBM19_HUMAN	RNA binding motif protein 19	480	RRM 3.				multicellular organismal development|positive regulation of embryonic development	chromosome|cytoplasm|nucleolus|nucleoplasm	nucleotide binding|RNA binding			skin(3)|ovary(1)|liver(1)|central_nervous_system(1)	6	Medulloblastoma(191;0.163)|all_neural(191;0.178)					TCCTTCTTGATGGTAGATGGT	0.562			NA											8	32					0	0	0.004482	0	0
NOS1	4842	broad.mit.edu	37	12	117660523	117660523	+	Silent	SNP	T	T	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr12:117660523T>A	uc001twm.1	-	26	4658	c.3972A>T	c.(3970-3972)CCA>CCT	p.P1324P		NM_000620	NP_000611	P29475	NOS1_HUMAN	nitric oxide synthase 1, neuronal	1324					multicellular organismal response to stress|myoblast fusion|negative regulation of calcium ion transport into cytosol|neurotransmitter biosynthetic process|nitric oxide biosynthetic process|platelet activation|positive regulation of vasodilation|regulation of cardiac muscle contraction|response to heat|response to hypoxia	cytoskeleton|cytosol|dendritic spine|perinuclear region of cytoplasm|photoreceptor inner segment|sarcolemma|sarcoplasmic reticulum	arginine binding|cadmium ion binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|tetrahydrobiopterin binding			ovary(3)|skin(3)|pancreas(1)	7	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.0561)	L-Citrulline(DB00155)	GGGTTACCTTTGGTTTGTCTG	0.552	Esophageal Squamous(162;1748 2599 51982 52956)		NA											73	117					0	0	0.01441	0	0
CABP1	9478	broad.mit.edu	37	12	121098917	121098917	+	Missense_Mutation	SNP	G	G	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr12:121098917G>A	uc001tyu.2	+	5	1050	c.983G>A	c.(982-984)CGA>CAA	p.R328Q	CABP1_uc001tyv.2_Missense_Mutation_p.R185Q|CABP1_uc001tyw.2_Missense_Mutation_p.R125Q|CABP1_uc001tyx.2_Missense_Mutation_p.R170Q	NM_001033677	NP_001028849	Q9NZU7	CABP1_HUMAN	calcium binding protein 1 isoform 3	328	EF-hand 3.					cell cortex|cell junction|Golgi apparatus|perinuclear region of cytoplasm|postsynaptic density|postsynaptic membrane	calcium ion binding|calcium-dependent protein binding|enzyme inhibitor activity|protein binding			central_nervous_system(1)	1	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)					AGTGAGCTGCGAGAGGCTATG	0.542			NA											13	44					0	0	0.001855	0	0
WDR66	144406	broad.mit.edu	37	12	122396299	122396299	+	Nonsense_Mutation	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr12:122396299C>T	uc009zxk.2	+	12	1994	c.1852C>T	c.(1852-1854)CAA>TAA	p.Q618*		NM_144668	NP_653269	Q8TBY9	WDR66_HUMAN	WD repeat domain 66	618	WD 6.						calcium ion binding			ovary(1)|skin(1)	2	all_neural(191;0.0496)|Medulloblastoma(191;0.0922)			OV - Ovarian serous cystadenocarcinoma(86;0.000155)|Epithelial(86;0.000634)|BRCA - Breast invasive adenocarcinoma(302;0.248)		CCACCCATATCAACCCCTCAT	0.463	Esophageal Squamous(85;849 1794 49757 52143)		NA											25	121					0	0	0.00278	0	0
UBC	7316	broad.mit.edu	37	12	125397990	125397990	+	Missense_Mutation	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr12:125397990C>T	uc001ugs.3	-	2	776	c.328G>A	c.(328-330)GAA>AAA	p.E110K	UBC_uc001ugr.2_5'Flank|UBC_uc001ugu.1_Missense_Mutation_p.E110K|UBC_uc001ugt.2_Missense_Mutation_p.E110K|UBC_uc001ugv.2_Intron|UBC_uc001ugw.2_5'UTR	NM_021009	NP_066289	P0CG48	UBC_HUMAN	ubiquitin C	110	Ubiquitin-like 2.				activation of MAPK activity|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|anti-apoptosis|apoptosis|cellular membrane organization|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA repair|endosome transport|epidermal growth factor receptor signaling pathway|G1/S transition of mitotic cell cycle|I-kappaB kinase/NF-kappaB cascade|induction of apoptosis by extracellular signals|innate immune response|JNK cascade|M/G1 transition of mitotic cell cycle|mRNA metabolic process|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of type I interferon production|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|S phase of mitotic cell cycle|stress-activated MAPK cascade|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|viral reproduction	cytosol|endocytic vesicle membrane|endosome membrane|nucleoplasm|plasma membrane	protein binding			ovary(2)	2	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;6.17e-05)|Epithelial(86;0.000207)|all cancers(50;0.00308)		GGAATGCCTTCCTTGTCCTGG	0.522			NA											32	222					0	0	0.013726	0	0
DHX37	57647	broad.mit.edu	37	12	125453184	125453184	+	Missense_Mutation	SNP	C	C	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr12:125453184C>A	uc001ugy.2	-	10	1403	c.1304G>T	c.(1303-1305)AGG>ATG	p.R435M		NM_032656	NP_116045	Q8IY37	DHX37_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 37	435							ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			skin(1)	1	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;8.05e-05)|Epithelial(86;0.000486)|all cancers(50;0.00653)		TGGGAACTGCCTGGATTCCAC	0.602			NA											45	149					2.43468e-25	3.34769e-25	0.01441	1	0
TMEM132B	114795	broad.mit.edu	37	12	126137061	126137061	+	Silent	SNP	G	G	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr12:126137061G>T	uc001uhe.1	+	8	1982	c.1974G>T	c.(1972-1974)GCG>GCT	p.A658A	TMEM132B_uc001uhf.1_Silent_p.A170A	NM_052907	NP_443139	Q14DG7	T132B_HUMAN	transmembrane protein 132B	658	Extracellular (Potential).					integral to membrane				skin(11)|ovary(5)|large_intestine(1)|pancreas(1)|breast(1)	19	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000423)|Epithelial(86;0.00394)|all cancers(50;0.0362)		TCACCATCGCGGAGCTGGGAG	0.587			NA											23	46					1.1804e-14	1.53854e-14	0.003954	1	0
EP400	57634	broad.mit.edu	37	12	132546780	132546780	+	Silent	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr12:132546780C>T	uc001ujn.2	+	45	8045	c.8010C>T	c.(8008-8010)GTC>GTT	p.V2670V	EP400_uc001ujl.2_Silent_p.V2669V|EP400_uc001ujm.2_Silent_p.V2589V|EP400_uc001ujp.2_5'Flank	NM_015409	NP_056224	Q96L91	EP400_HUMAN	E1A binding protein p400	2706	Interaction with ZNF42 (By similarity).				histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nuclear speck	ATP binding|DNA binding|helicase activity			central_nervous_system(4)|ovary(3)|breast(3)|skin(2)	12	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.198)		OV - Ovarian serous cystadenocarcinoma(86;3.01e-08)|Epithelial(86;3.43e-07)|all cancers(50;2.01e-06)		TTCGAGCGGTCACTTCTGTGA	0.662			NA											15	99					0	0	0.00245	0	0
PGAM5	192111	broad.mit.edu	37	12	133291505	133291505	+	Missense_Mutation	SNP	C	C	G			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr12:133291505C>G	uc009zyv.2	+	2	280	c.253C>G	c.(253-255)CTG>GTG	p.L85V	PGAM5_uc010tbr.1_RNA|PGAM5_uc001uku.2_Missense_Mutation_p.L85V	NM_138575	NP_612642	Q96HS1	PGAM5_HUMAN	phosphoglycerate mutase family member 5	85						integral to membrane|mitochondrial outer membrane	phosphoprotein phosphatase activity				0	all_neural(191;0.0982)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.89e-08)|Epithelial(86;1.14e-07)|all cancers(50;3.57e-06)		GGAAGAAGAGCTGGCGTCCAA	0.542			NA											8	87					0	0	0.008291	0	0
SACS	26278	broad.mit.edu	37	13	23913317	23913317	+	Silent	SNP	G	G	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr13:23913317G>A	uc001uon.2	-	10	5287	c.4698C>T	c.(4696-4698)ATC>ATT	p.I1566I	SACS_uc001uoo.2_Silent_p.I1419I|SACS_uc001uop.1_Intron|SACS_uc001uoq.1_Intron	NM_014363	NP_055178	Q9NZJ4	SACS_HUMAN	sacsin	1566					cell death|negative regulation of inclusion body assembly|protein folding	axon|cell body fiber|dendrite|mitochondrion|nucleus	ATP binding|chaperone binding|Hsp70 protein binding|proteasome binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		all_cancers(29;1.51e-22)|all_epithelial(30;7.82e-19)|all_lung(29;4.71e-18)|Lung SC(185;0.0225)|Breast(139;0.128)		all cancers(112;0.00197)|Epithelial(112;0.00854)|OV - Ovarian serous cystadenocarcinoma(117;0.0298)|Lung(94;0.189)		GAATGTCAGTGATATGGTACA	0.343			NA											5	48					0	0	0.001168	0	0
ATP8A2	51761	broad.mit.edu	37	13	26155990	26155990	+	Missense_Mutation	SNP	G	G	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr13:26155990G>T	uc001uqk.2	+	23	2183	c.2041G>T	c.(2041-2043)GAT>TAT	p.D681Y	ATP8A2_uc010tdi.1_Missense_Mutation_p.D641Y|ATP8A2_uc010tdj.1_RNA|ATP8A2_uc010aaj.1_Missense_Mutation_p.D191Y	NM_016529	NP_057613	Q9NTI2	AT8A2_HUMAN	ATPase, aminophospholipid transporter-like,	641	Cytoplasmic (Potential).				ATP biosynthetic process|negative regulation of cell proliferation	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(2)|large_intestine(1)|skin(1)	4		Breast(139;0.0201)|Lung SC(185;0.0225)		all cancers(112;0.043)|OV - Ovarian serous cystadenocarcinoma(117;0.0748)|Epithelial(112;0.079)		AGCCATAGAAGATCGCCTTCA	0.393			NA											18	29					3.52763e-06	3.97372e-06	0.00499	1	0
FLT3	2322	broad.mit.edu	37	13	28578214	28578214	+	Missense_Mutation	SNP	G	G	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr13:28578214G>T	uc001urw.2	-	24	3039	c.2957C>A	c.(2956-2958)CCG>CAG	p.P986Q	FLT3_uc010aao.2_RNA|FLT3_uc010tdn.1_Missense_Mutation_p.P945Q	NM_004119	NP_004110	P36888	FLT3_HUMAN	fms-related tyrosine kinase 3 precursor	986	Cytoplasmic (Potential).				positive regulation of cell proliferation	integral to plasma membrane	ATP binding|vascular endothelial growth factor receptor activity			haematopoietic_and_lymphoid_tissue(8536)|lung(7)|ovary(3)|stomach(1)|central_nervous_system(1)|skin(1)	8549	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0156)|Ovarian(182;0.0392)	Colorectal(13;0.000157)|READ - Rectum adenocarcinoma(15;0.105)	OV - Ovarian serous cystadenocarcinoma(117;0.00154)|all cancers(112;0.00459)|GBM - Glioblastoma multiforme(144;0.00562)|Epithelial(112;0.0959)|Lung(94;0.212)	Sorafenib(DB00398)|Sunitinib(DB01268)	CTGAGCCTGCGGAGAGAGTAG	0.463			NA	Mis|O		AML|ALL								17	27					1.15088e-07	1.34873e-07	0.004007	1	0
FLT1	2321	broad.mit.edu	37	13	28880878	28880878	+	Missense_Mutation	SNP	G	G	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr13:28880878G>T	uc001usb.3	-	29	4037	c.3752C>A	c.(3751-3753)GCC>GAC	p.A1251D	FLT1_uc010aap.2_Missense_Mutation_p.A256D|FLT1_uc010aaq.2_Missense_Mutation_p.A376D|FLT1_uc001usa.3_Missense_Mutation_p.A469D	NM_002019	NP_002010	P17948	VGFR1_HUMAN	fms-related tyrosine kinase 1 isoform 1	1251	Cytoplasmic (Potential).				cell differentiation|female pregnancy|positive regulation of vascular endothelial growth factor receptor signaling pathway	extracellular space|Golgi apparatus|integral to plasma membrane|nucleus	ATP binding|growth factor binding|vascular endothelial growth factor receptor activity			lung(10)|central_nervous_system(5)|ovary(3)|stomach(2)|skin(2)|urinary_tract(1)|breast(1)	24	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0262)|Breast(139;0.188)	Colorectal(13;0.000674)	all cancers(112;0.0301)|Epithelial(112;0.155)|GBM - Glioblastoma multiforme(144;0.184)|OV - Ovarian serous cystadenocarcinoma(117;0.205)|Lung(94;0.207)	Sunitinib(DB01268)	CATGGGAGAGGCCAACAGAGT	0.547			NA											6	36					5.9392e-07	6.8551e-07	0.001168	1	0
FLT1	2321	broad.mit.edu	37	13	29001982	29001982	+	Missense_Mutation	SNP	C	C	G			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr13:29001982C>G	uc001usb.3	-	9	1468	c.1183G>C	c.(1183-1185)GTA>CTA	p.V395L	FLT1_uc010aar.1_Missense_Mutation_p.V395L|FLT1_uc001usc.3_Missense_Mutation_p.V395L|FLT1_uc010tdp.1_Missense_Mutation_p.V395L	NM_002019	NP_002010	P17948	VGFR1_HUMAN	fms-related tyrosine kinase 1 isoform 1	395	Ig-like C2-type 4.|Extracellular (Potential).				cell differentiation|female pregnancy|positive regulation of vascular endothelial growth factor receptor signaling pathway	extracellular space|Golgi apparatus|integral to plasma membrane|nucleus	ATP binding|growth factor binding|vascular endothelial growth factor receptor activity			lung(10)|central_nervous_system(5)|ovary(3)|stomach(2)|skin(2)|urinary_tract(1)|breast(1)	24	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0262)|Breast(139;0.188)	Colorectal(13;0.000674)	all cancers(112;0.0301)|Epithelial(112;0.155)|GBM - Glioblastoma multiforme(144;0.184)|OV - Ovarian serous cystadenocarcinoma(117;0.205)|Lung(94;0.207)	Sunitinib(DB01268)	TCTTCAGTTACGTCCTTGATA	0.388			NA											15	39					0	0	0.003163	0	0
MTUS2	23281	broad.mit.edu	37	13	29600034	29600034	+	Missense_Mutation	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr13:29600034C>T	uc001usl.3	+	1	1287	c.1229C>T	c.(1228-1230)TCT>TTT	p.S410F		NM_001033602	NP_001028774	Q5JR59	MTUS2_HUMAN	hypothetical protein LOC23281 isoform a	400						cytoplasm|microtubule	microtubule binding|protein homodimerization activity				0						AAACAGGGCTCTGCTTCCTTA	0.547			NA											5	15					0	0	0.000602	0	0
NBEA	26960	broad.mit.edu	37	13	35624523	35624523	+	Missense_Mutation	SNP	A	A	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr13:35624523A>T	uc001uvb.2	+	7	1169	c.963A>T	c.(961-963)CAA>CAT	p.Q321H		NM_015678	NP_056493	Q8NFP9	NBEA_HUMAN	neurobeachin	321						cytosol|endomembrane system|plasma membrane|trans-Golgi network	protein binding			ovary(9)|large_intestine(2)	11		Breast(139;0.0141)|Lung SC(185;0.0548)|Prostate(109;0.207)		all cancers(112;1.93e-08)|Epithelial(112;1.62e-07)|BRCA - Breast invasive adenocarcinoma(63;0.00033)|OV - Ovarian serous cystadenocarcinoma(117;0.00109)|KIRC - Kidney renal clear cell carcinoma(186;0.00575)|Kidney(163;0.00656)|GBM - Glioblastoma multiforme(144;0.191)|Lung(94;0.199)		ATGATTTTCAACCACGCAAGG	0.353			NA											3	5					0	0	0.004672	0	0
NBEA	26960	broad.mit.edu	37	13	36241513	36241513	+	Missense_Mutation	SNP	G	G	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr13:36241513G>T	uc001uvb.2	+	56	8610	c.8404G>T	c.(8404-8406)GGC>TGC	p.G2802C	NBEA_uc010abi.2_Missense_Mutation_p.G1460C|NBEA_uc010tef.1_Missense_Mutation_p.G595C|NBEA_uc001uvd.2_Missense_Mutation_p.G380C	NM_015678	NP_056493	Q8NFP9	NBEA_HUMAN	neurobeachin	2802	WD 3.					cytosol|endomembrane system|plasma membrane|trans-Golgi network	protein binding			ovary(9)|large_intestine(2)	11		Breast(139;0.0141)|Lung SC(185;0.0548)|Prostate(109;0.207)		all cancers(112;1.93e-08)|Epithelial(112;1.62e-07)|BRCA - Breast invasive adenocarcinoma(63;0.00033)|OV - Ovarian serous cystadenocarcinoma(117;0.00109)|KIRC - Kidney renal clear cell carcinoma(186;0.00575)|Kidney(163;0.00656)|GBM - Glioblastoma multiforme(144;0.191)|Lung(94;0.199)		CTTTGCAGAGGGCCCTTGCCT	0.532			NA											7	55					1.06961e-07	1.25857e-07	0.00308	1	0
DCLK1	9201	broad.mit.edu	37	13	36699915	36699915	+	Silent	SNP	C	C	G			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr13:36699915C>G	uc001uvf.2	-	2	593	c.360G>C	c.(358-360)CTG>CTC	p.L120L		NM_004734	NP_004725	O15075	DCLK1_HUMAN	doublecortin-like kinase 1	120	Doublecortin 1.				cell differentiation|central nervous system development|endosome transport|intracellular signal transduction|response to virus	integral to plasma membrane	ATP binding|protein serine/threonine kinase activity|receptor signaling protein activity			stomach(6)|ovary(2)|skin(1)	9		Breast(139;0.0147)|Lung SC(185;0.0685)|Prostate(109;0.122)	KIRC - Kidney renal clear cell carcinoma(5;0.119)|Kidney(79;0.169)	all cancers(112;1.72e-06)|Epithelial(112;4.24e-05)|BRCA - Breast invasive adenocarcinoma(63;0.00159)|OV - Ovarian serous cystadenocarcinoma(117;0.0158)|GBM - Glioblastoma multiforme(144;0.0638)		CCAGTTGGTCCAGGCTGGAAA	0.522			NA											16	36					0	0	0.004007	0	0
TRPC4	7223	broad.mit.edu	37	13	38266182	38266182	+	Silent	SNP	A	A	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr13:38266182A>T	uc001uws.2	-	4	1423	c.1188T>A	c.(1186-1188)GGT>GGA	p.G396G	TRPC4_uc010abv.2_Intron|TRPC4_uc001uwt.2_Silent_p.G396G|TRPC4_uc010tey.1_Silent_p.G396G|TRPC4_uc010abw.2_Silent_p.G223G|TRPC4_uc010abx.2_Silent_p.G396G|TRPC4_uc010aby.2_Silent_p.G396G	NM_016179	NP_057263	Q9UBN4	TRPC4_HUMAN	transient receptor potential cation channel,	396	Cytoplasmic (Potential).				axon guidance|calcium ion import	basolateral plasma membrane|calcium channel complex|cell surface|cortical cytoskeleton	beta-catenin binding|cadherin binding|store-operated calcium channel activity			ovary(3)|skin(2)|breast(1)	6				all cancers(112;1.92e-08)|Epithelial(112;5.04e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000677)|GBM - Glioblastoma multiforme(144;0.00623)|BRCA - Breast invasive adenocarcinoma(63;0.0126)		TTGGTGGTGGACCTTGCCTGT	0.433			NA											23	26					0	0	0.00278	0	0
TRPC4	7223	broad.mit.edu	37	13	38266380	38266380	+	Missense_Mutation	SNP	C	C	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr13:38266380C>A	uc001uws.2	-	4	1225	c.990G>T	c.(988-990)ATG>ATT	p.M330I	TRPC4_uc010abv.2_Intron|TRPC4_uc001uwt.2_Missense_Mutation_p.M330I|TRPC4_uc010tey.1_Missense_Mutation_p.M330I|TRPC4_uc010abw.2_Missense_Mutation_p.M157I|TRPC4_uc010abx.2_Missense_Mutation_p.M330I|TRPC4_uc010aby.2_Missense_Mutation_p.M330I	NM_016179	NP_057263	Q9UBN4	TRPC4_HUMAN	transient receptor potential cation channel,	330	Helical; (Potential).				axon guidance|calcium ion import	basolateral plasma membrane|calcium channel complex|cell surface|cortical cytoskeleton	beta-catenin binding|cadherin binding|store-operated calcium channel activity			ovary(3)|skin(2)|breast(1)	6				all cancers(112;1.92e-08)|Epithelial(112;5.04e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000677)|GBM - Glioblastoma multiforme(144;0.00623)|BRCA - Breast invasive adenocarcinoma(63;0.0126)		AACATGTCACCATCTTCACTG	0.478			NA											6	30					0.00116845	0.00122497	0.001168	1	0
KBTBD6	89890	broad.mit.edu	37	13	41706012	41706012	+	Missense_Mutation	SNP	C	C	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr13:41706012C>A	uc001uxu.1	-	1	925	c.636G>T	c.(634-636)GAG>GAT	p.E212D	KBTBD6_uc010ace.1_Intron|KBTBD6_uc010tfe.1_Missense_Mutation_p.E146D|uc001uxv.1_5'Flank	NM_152903	NP_690867	Q86V97	KBTB6_HUMAN	kelch repeat and BTB (POZ) domain-containing 6	212							protein binding			ovary(1)|skin(1)	2		Lung NSC(96;4.52e-06)|Breast(139;0.00123)|Prostate(109;0.0181)|Lung SC(185;0.0262)|Hepatocellular(98;0.114)		all cancers(112;4.08e-09)|Epithelial(112;4.74e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000131)|GBM - Glioblastoma multiforme(144;0.000876)|BRCA - Breast invasive adenocarcinoma(63;0.0673)		CTGCTAGAGTCTCCTCCCGAA	0.562			NA											17	112					6.49762e-13	8.27592e-13	0.006122	1	0
ENOX1	55068	broad.mit.edu	37	13	43930179	43930179	+	Missense_Mutation	SNP	C	C	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr13:43930179C>A	uc001uza.3	-	8	999	c.699G>T	c.(697-699)AGG>AGT	p.R233S	ENOX1_uc001uzb.3_Missense_Mutation_p.R233S|ENOX1_uc001uzc.3_Missense_Mutation_p.R233S|ENOX1_uc001uyz.3_5'UTR|ENOX1_uc010tfm.1_Missense_Mutation_p.R46S	NM_001127615	NP_001121087	Q8TC92	ENOX1_HUMAN	ecto-NOX disulfide-thiol exchanger 1	233					electron transport chain|rhythmic process|transport	extracellular space|plasma membrane	nucleic acid binding|nucleotide binding|oxidoreductase activity			pancreas(1)|skin(1)	2		Lung NSC(96;0.000518)|Prostate(109;0.0233)|Hepatocellular(98;0.0268)|Lung SC(185;0.0367)|Breast(139;0.0406)		GBM - Glioblastoma multiforme(144;0.00333)|BRCA - Breast invasive adenocarcinoma(63;0.172)		GGGCACGCATCCTCTGCTTGC	0.617			NA											20	163					4.96729e-08	5.87338e-08	0.008871	1	0
CCDC70	83446	broad.mit.edu	37	13	52439604	52439604	+	Silent	SNP	G	G	C	rs112168960		TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr13:52439604G>C	uc001vfu.3	+	2	386	c.90G>C	c.(88-90)GCG>GCC	p.A30A	uc010tgr.1_RNA	NM_031290	NP_112580	Q6NSX1	CCD70_HUMAN	coiled-coil domain containing 70 precursor	30						extracellular region|plasma membrane					0		Breast(56;0.000207)|Lung NSC(96;0.00145)|Prostate(109;0.0107)|Hepatocellular(98;0.065)|all_neural(104;0.19)		GBM - Glioblastoma multiforme(99;2.4e-08)		GGTCCCTGGCGGCATCCTCTC	0.507			NA											19	104					0	0	0.014323	0	0
ATP7B	540	broad.mit.edu	37	13	52511514	52511514	+	Missense_Mutation	SNP	C	C	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr13:52511514C>A	uc001vfw.2	-	19	4076	c.3919G>T	c.(3919-3921)GTG>TTG	p.V1307L	ATP7B_uc010adv.2_Missense_Mutation_p.V877L|ATP7B_uc001vfx.2_Missense_Mutation_p.V1100L|ATP7B_uc001vfy.2_Missense_Mutation_p.V1196L|ATP7B_uc010tgt.1_Missense_Mutation_p.V1242L|ATP7B_uc010tgu.1_Missense_Mutation_p.V1259L|ATP7B_uc010tgv.1_Missense_Mutation_p.V1229L|ATP7B_uc001vfv.2_Missense_Mutation_p.V579L|ATP7B_uc010tgs.1_Missense_Mutation_p.V518L	NM_000053	NP_000044	P35670	ATP7B_HUMAN	ATPase, Cu++ transporting, beta polypeptide	1307	Cytoplasmic (Potential).				ATP biosynthetic process|cellular copper ion homeostasis|copper ion import|response to copper ion|sequestering of calcium ion	Golgi membrane|integral to plasma membrane|late endosome|mitochondrion	ATP binding|copper ion binding|copper-exporting ATPase activity|protein binding			ovary(1)|central_nervous_system(1)|skin(1)	3		Breast(56;0.000207)|Lung NSC(96;0.000845)|Prostate(109;0.0235)|Hepatocellular(98;0.065)|all_neural(104;0.19)		GBM - Glioblastoma multiforme(99;5.25e-08)		CTAGCCACCACATCCAGCAAA	0.552			NA							Wilson_disease				47	58					1.61004e-24	2.21171e-24	0.01441	1	0
KLHL1	57626	broad.mit.edu	37	13	70535449	70535449	+	Missense_Mutation	SNP	C	C	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr13:70535449C>A	uc001vip.2	-	3	1602	c.808G>T	c.(808-810)GCA>TCA	p.A270S	KLHL1_uc010thm.1_Missense_Mutation_p.A209S	NM_020866	NP_065917	Q9NR64	KLHL1_HUMAN	kelch-like 1 protein	270	BTB.				actin cytoskeleton organization	cytoplasm|cytoskeleton	actin binding				0		Breast(118;0.000162)		COAD - Colon adenocarcinoma(199;0.000193)|GBM - Glioblastoma multiforme(99;0.000211)		CCTGTATATGCAAATTGGACA	0.353			NA											6	15					3.59834e-05	3.94026e-05	0.001168	1	0
KLHL1	57626	broad.mit.edu	37	13	70681521	70681521	+	Missense_Mutation	SNP	T	T	G			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr13:70681521T>G	uc001vip.2	-	1	1105	c.311A>C	c.(310-312)CAG>CCG	p.Q104P	KLHL1_uc010thm.1_Missense_Mutation_p.Q104P|ATXN8OS_uc010aej.1_RNA	NM_020866	NP_065917	Q9NR64	KLHL1_HUMAN	kelch-like 1 protein	104					actin cytoskeleton organization	cytoplasm|cytoskeleton	actin binding				0		Breast(118;0.000162)		COAD - Colon adenocarcinoma(199;0.000193)|GBM - Glioblastoma multiforme(99;0.000211)		AGCCCCTTGCTGCAGCCTCGT	0.453			NA											33	25					0	0	0.010818	0	0
DIS3	22894	broad.mit.edu	37	13	73334716	73334716	+	Missense_Mutation	SNP	G	G	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr13:73334716G>A	uc001vix.3	-	20	3118	c.2744C>T	c.(2743-2745)TCA>TTA	p.S915L	DIS3_uc001viy.3_Missense_Mutation_p.S885L|DIS3_uc001viz.2_RNA	NM_014953	NP_055768	Q9Y2L1	RRP44_HUMAN	DIS3 mitotic control isoform a	915					CUT catabolic process|exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|rRNA catabolic process|rRNA processing	cytosol|exosome (RNase complex)|nucleolus|nucleoplasm	3'-5'-exoribonuclease activity|endonuclease activity|guanyl-nucleotide exchange factor activity|protein binding|RNA binding			central_nervous_system(1)	1		Breast(118;0.0074)|Acute lymphoblastic leukemia(28;0.0195)		GBM - Glioblastoma multiforme(99;0.000181)		AAGATTAGATGAGTCTAACAT	0.328			NA								Multiple Myeloma(4;0.011)			4	40					0	0	0.001168	0	0
CLN5	1203	broad.mit.edu	37	13	77566091	77566091	+	Missense_Mutation	SNP	G	G	C			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr13:77566091G>C	uc001vkc.2	+	1	33	c.5G>C	c.(4-6)CGC>CCC	p.R2P		NM_006493	NP_006484	O75503	CLN5_HUMAN	ceroid-lipofuscinosis, neuronal 5	Error:Variant_position_missing_in_O75503_after_alignment					brain development|cell death|lysosomal lumen acidification|neuron maturation|protein catabolic process	endoplasmic reticulum|Golgi apparatus|integral to membrane|lysosomal membrane|perinuclear region of cytoplasm	protein binding			ovary(1)	1		Acute lymphoblastic leukemia(28;0.205)		GBM - Glioblastoma multiforme(99;0.0503)		GGTGTCATGCGCCGGAACCTG	0.592			NA											6	9					0	0	0.001168	0	0
MYCBP2	23077	broad.mit.edu	37	13	77765894	77765894	+	Missense_Mutation	SNP	C	C	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr13:77765894C>A	uc001vkf.2	-	29	3967	c.3876G>T	c.(3874-3876)TGG>TGT	p.W1292C	MYCBP2_uc010aev.2_Missense_Mutation_p.W696C	NM_015057	NP_055872	O75592	MYCB2_HUMAN	MYC binding protein 2	1292					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ligase activity|protein binding|zinc ion binding			ovary(4)|breast(4)|skin(3)|lung(2)|pancreas(1)	14		Breast(118;0.212)|Acute lymphoblastic leukemia(28;0.22)		GBM - Glioblastoma multiforme(99;0.109)		ATGCCACATACCACCACCCAG	0.438			NA											14	19					1.5842e-08	1.8979e-08	0.001855	1	0
ABCC4	10257	broad.mit.edu	37	13	95862948	95862948	+	Nonsense_Mutation	SNP	G	G	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr13:95862948G>A	uc001vmd.3	-	5	738	c.619C>T	c.(619-621)CAG>TAG	p.Q207*	ABCC4_uc010afk.2_Nonsense_Mutation_p.Q207*|ABCC4_uc001vme.2_Nonsense_Mutation_p.Q207*|ABCC4_uc010tih.1_Nonsense_Mutation_p.Q132*|ABCC4_uc001vmf.2_Nonsense_Mutation_p.Q164*|ABCC4_uc010afl.1_Nonsense_Mutation_p.Q164*|ABCC4_uc010afm.1_Nonsense_Mutation_p.Q220*	NM_005845	NP_005836	O15439	MRP4_HUMAN	ATP-binding cassette, sub-family C, member 4	207	ABC transmembrane type-1 1.|Helical; (Potential).				platelet activation|platelet degranulation	integral to membrane|membrane fraction|plasma membrane|platelet dense granule membrane	15-hydroxyprostaglandin dehydrogenase (NAD+) activity|ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|chloride channel activity			central_nervous_system(3)|skin(1)	4	all_neural(89;0.0878)|Medulloblastoma(90;0.163)				Cefazolin(DB01327)	CAGCTTACCTGATCAAACTTG	0.353			NA											6	50					0	0	0.001168	0	0
COL4A1	1282	broad.mit.edu	37	13	110817207	110817207	+	Splice_Site	SNP	A	A	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr13:110817207A>T	uc001vqw.3	-	46	4272	c.4150_splice	c.e46+1	p.G1384_splice	COL4A1_uc010agl.2_Intron	NM_001845	NP_001836	P02462	CO4A1_HUMAN	alpha 1 type IV collagen preproprotein						angiogenesis|axon guidance		extracellular matrix structural constituent|platelet-derived growth factor binding			ovary(3)|lung(1)|central_nervous_system(1)|pancreas(1)	6	all_cancers(4;9.8e-13)|all_epithelial(4;9.66e-08)|all_lung(23;3.75e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00178)|all_neural(89;0.00459)|Medulloblastoma(90;0.00596)|Lung SC(71;0.0604)	Breast(118;0.2)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.145)			AAGCCTTCTCACCTTGCTGGC	0.597			NA											4	36					0	0	0.009096	0	0
SOX1	6656	broad.mit.edu	37	13	112722007	112722007	+	Missense_Mutation	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr13:112722007C>T	uc001vsb.1	+	1	95	c.35C>T	c.(34-36)TCG>TTG	p.S12L		NM_005986	NP_005977	O00570	SOX1_HUMAN	SRY (sex determining region Y)-box 1	12					chromatin organization	nucleus	core promoter sequence-specific DNA binding|protein binding|sequence-specific DNA binding transcription factor activity				0	all_lung(23;0.000652)|Lung NSC(43;0.017)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Medulloblastoma(90;0.163)	all_cancers(25;0.000331)|Lung NSC(25;0.0496)|all_lung(25;0.0831)|all_epithelial(44;0.0868)|Breast(118;0.231)		OV - Ovarian serous cystadenocarcinoma(48;0.132)		GACCTGCACTCGCCCGGCGGC	0.567			NA											5	32					0	0	0.000602	0	0
MCF2L	23263	broad.mit.edu	37	13	113719264	113719264	+	Silent	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr13:113719264C>T	uc001vsu.2	+	7	814	c.792C>T	c.(790-792)TTC>TTT	p.F264F	MCF2L_uc001vsq.2_Silent_p.F264F|MCF2L_uc010tjr.1_Silent_p.F207F|MCF2L_uc001vsr.2_Silent_p.F211F|MCF2L_uc001vss.3_Silent_p.F205F|MCF2L_uc010tjs.1_Silent_p.F205F|MCF2L_uc001vst.1_Silent_p.F169F	NM_001112732	NP_001106203	O15068	MCF2L_HUMAN	MCF.2 cell line derived transforming	237					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|plasma membrane	Rho guanyl-nucleotide exchange factor activity			ovary(1)|kidney(1)	2	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)	all_cancers(25;0.118)|all_lung(25;0.0368)|all_epithelial(44;0.0396)|Lung NSC(25;0.129)|Breast(118;0.188)				TCGAAAGTTTCGCCCTCATGG	0.577			NA											30	52					0	0	0.010818	0	0
RASA3	22821	broad.mit.edu	37	13	114773076	114773076	+	Missense_Mutation	SNP	C	C	G			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr13:114773076C>G	uc001vui.2	-	18	1806	c.1675G>C	c.(1675-1677)GAT>CAT	p.D559H	RASA3_uc010tkk.1_Missense_Mutation_p.D527H|RASA3_uc001vuj.2_Missense_Mutation_p.D176H	NM_007368	NP_031394	Q14644	RASA3_HUMAN	RAS p21 protein activator 3	559					intracellular signal transduction|negative regulation of Ras protein signal transduction	cytoplasm|intrinsic to internal side of plasma membrane	calcium-release channel activity|metal ion binding|Ras GTPase activator activity			lung(3)|skin(1)	4	Lung NSC(43;0.00814)|all_neural(89;0.0337)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.016)|all_epithelial(44;0.00577)|all_lung(25;0.0173)|Lung NSC(25;0.0634)|Breast(118;0.188)	BRCA - Breast invasive adenocarcinoma(86;0.128)			GAAATCAGATCCAAGAACTAA	0.438			NA											8	51					0	0	0.004482	0	0
CHD8	57680	broad.mit.edu	37	14	21860668	21860668	+	Missense_Mutation	SNP	C	C	G			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr14:21860668C>G	uc001was.1	-	34	6026	c.5932G>C	c.(5932-5934)GAT>CAT	p.D1978H	CHD8_uc001war.1_Missense_Mutation_p.D1874H|SNORD9_uc001wat.1_5'Flank	NM_020920	NP_065971	Q9HCK8	CHD8_HUMAN	chromodomain helicase DNA binding protein 8	2257					ATP-dependent chromatin remodeling|canonical Wnt receptor signaling pathway|negative regulation of transcription, DNA-dependent|negative regulation of Wnt receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase III promoter|transcription, DNA-dependent	MLL1 complex	ATP binding|beta-catenin binding|DNA binding|DNA helicase activity|DNA-dependent ATPase activity|methylated histone residue binding|p53 binding			ovary(6)|upper_aerodigestive_tract(1)|large_intestine(1)|breast(1)|skin(1)	10	all_cancers(95;0.00121)		Epithelial(56;2.55e-06)|all cancers(55;1.73e-05)	GBM - Glioblastoma multiforme(265;0.00424)		GAGCTTACATCTTTGATTTGA	0.463			NA											21	110					0	0	0.012319	0	0
OR4E2	26686	broad.mit.edu	37	14	22133522	22133522	+	Missense_Mutation	SNP	G	G	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr14:22133522G>T	uc010tmd.1	+	1	226	c.226G>T	c.(226-228)GTC>TTC	p.V76F		NM_001001912	NP_001001912	Q8NGC2	OR4E2_HUMAN	olfactory receptor, family 4, subfamily E,	76	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|pancreas(1)|skin(1)	4	all_cancers(95;0.00113)	Acute lymphoblastic leukemia(2;0.0279)		GBM - Glioblastoma multiforme(265;0.0137)		CCACTCATCTGTCACTGTGCC	0.433			NA											35	180					1.62565e-12	2.06332e-12	0.012213	1	0
NGDN	25983	broad.mit.edu	37	14	23945466	23945466	+	Missense_Mutation	SNP	G	G	C			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr14:23945466G>C	uc001wjy.2	+	8	590	c.563G>C	c.(562-564)CGG>CCG	p.R188P	NGDN_uc001wjz.2_Missense_Mutation_p.R188P|NGDN_uc001wka.2_RNA	NM_001042635	NP_001036100	Q8NEJ9	NGDN_HUMAN	neuroguidin isoform 1	188	Potential.				regulation of translation	axon|cytoplasm|dendrite|filopodium|nucleus					0	all_cancers(95;0.000251)			GBM - Glioblastoma multiforme(265;0.00654)		GAAGCTGAGCGGGAGAAGAAG	0.468			NA											9	55					0	0	0.006214	0	0
IRF9	10379	broad.mit.edu	37	14	24631533	24631533	+	Missense_Mutation	SNP	G	G	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr14:24631533G>T	uc001wmq.2	+	2	307	c.180G>T	c.(178-180)AAG>AAT	p.K60N	RNF31_uc001wmp.2_RNA|IRF9_uc010alj.2_5'Flank	NM_006084	NP_006075	Q00978	IRF9_HUMAN	interferon-stimulated transcription factor 3,	60	IRF tryptophan pentad repeat.				interferon-gamma-mediated signaling pathway|response to virus|transcription from RNA polymerase II promoter|type I interferon-mediated signaling pathway	cytosol|nucleoplasm	DNA binding|identical protein binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1				GBM - Glioblastoma multiforme(265;0.00853)		CCTTCTTCAAGGTGAAAGGGC	0.532			NA											19	70					2.5808e-16	3.41597e-16	0.006122	1	0
KHNYN	23351	broad.mit.edu	37	14	24901483	24901483	+	Missense_Mutation	SNP	G	G	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr14:24901483G>T	uc001wph.3	+	3	1218	c.1016G>T	c.(1015-1017)CGA>CTA	p.R339L	KHNYN_uc010tpc.1_Missense_Mutation_p.R380L|KHNYN_uc010alw.2_Missense_Mutation_p.R339L|CBLN3_uc001wpg.3_5'Flank	NM_015299	NP_056114	O15037	KHNYN_HUMAN	hypothetical protein LOC23351	339										ovary(2)|liver(1)	3						GCTCAGTCCCGAGGAGCCTCC	0.667			NA									OREG0022627	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	41	61					3.05275e-18	4.08157e-18	0.013114	1	0
NOVA1	4857	broad.mit.edu	37	14	26917884	26917884	+	Missense_Mutation	SNP	C	C	G			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr14:26917884C>G	uc001wpy.2	-	5	1123	c.805G>C	c.(805-807)GGA>CGA	p.G269R	NOVA1_uc001wpz.2_Missense_Mutation_p.G245R|NOVA1_uc001wqa.2_Missense_Mutation_p.G147R	NM_002515	NP_002506	P51513	NOVA1_HUMAN	neuro-oncological ventral antigen 1 isoform 1	272					locomotory behavior|RNA splicing|synaptic transmission	nucleus	RNA binding			skin(2)|upper_aerodigestive_tract(1)|breast(1)|liver(1)	5				GBM - Glioblastoma multiforme(265;0.0135)		TAAGGAGATCCGGTTGGATTG	0.483			NA											14	64					0	0	0.003163	0	0
NPAS3	64067	broad.mit.edu	37	14	34269356	34269356	+	Missense_Mutation	SNP	C	C	G			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr14:34269356C>G	uc001wru.2	+	12	1907	c.1843C>G	c.(1843-1845)CGG>GGG	p.R615G	NPAS3_uc001wrs.2_Missense_Mutation_p.R602G|NPAS3_uc001wrt.2_Missense_Mutation_p.R583G|NPAS3_uc001wrv.2_Missense_Mutation_p.R585G	NM_173159	NP_071406	Q8IXF0	NPAS3_HUMAN	neuronal PAS domain protein 3 isoform 3	615					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|signal transducer activity			ovary(1)|skin(1)	2	Breast(36;0.0102)|Hepatocellular(127;0.133)		LUAD - Lung adenocarcinoma(48;0.00169)|Lung(238;0.00968)	GBM - Glioblastoma multiforme(1;1.31e-09)|all cancers(1;0.000112)|OV - Ovarian serous cystadenocarcinoma(311;0.115)		CGCCAGCCGCCGGCGCCTGTC	0.721			NA											8	15					0	0	0.004482	0	0
CLEC14A	161198	broad.mit.edu	37	14	38724115	38724115	+	Silent	SNP	G	G	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr14:38724115G>T	uc001wum.1	-	1	1460	c.1113C>A	c.(1111-1113)ACC>ACA	p.T371T		NM_175060	NP_778230	Q86T13	CLC14_HUMAN	C-type lectin domain family 14, member A	371	Extracellular (Potential).					integral to membrane	sugar binding			ovary(3)|skin(1)	4	Hepatocellular(127;0.213)|Esophageal squamous(585;0.22)		Lung(238;3.93e-06)|LUAD - Lung adenocarcinoma(48;2.62e-05)|Epithelial(34;0.187)	GBM - Glioblastoma multiforme(112;0.00439)		TCCCTGATGGGGTGATAGTGG	0.488			NA											9	45					1.76689e-08	2.10981e-08	0.006214	1	0
LRFN5	145581	broad.mit.edu	37	14	42355849	42355849	+	Nonsense_Mutation	SNP	T	T	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr14:42355849T>A	uc001wvm.2	+	3	1219	c.21T>A	c.(19-21)TAT>TAA	p.Y7*	LRFN5_uc010ana.2_Nonsense_Mutation_p.Y7*	NM_152447	NP_689660	Q96NI6	LRFN5_HUMAN	leucine rich repeat and fibronectin type III	7						integral to membrane				ovary(5)|pancreas(2)|central_nervous_system(1)	8			LUAD - Lung adenocarcinoma(50;0.0223)|Lung(238;0.0728)	GBM - Glioblastoma multiforme(112;0.00847)		TTCTTTTTTATCTGTTTCTCA	0.363			NA								HNSCC(30;0.082)			6	15					0	0	0.001984	0	0
KLHL28	54813	broad.mit.edu	37	14	45415050	45415050	+	Missense_Mutation	SNP	G	G	C			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr14:45415050G>C	uc001wvq.2	-	2	328	c.82C>G	c.(82-84)CTT>GTT	p.L28V	KLHL28_uc001wvr.2_Missense_Mutation_p.L28V|KLHL28_uc001wvt.3_Missense_Mutation_p.L28V	NM_017658	NP_060128	Q9NXS3	KLH28_HUMAN	BTB (POZ) domain containing 5	28										ovary(1)	1						TGTTGGCGAAGAAGATTCAAG	0.433			NA											4	34					0	0	0.009096	0	0
FANCM	57697	broad.mit.edu	37	14	45644332	45644332	+	Nonsense_Mutation	SNP	C	C	G			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr14:45644332C>G	uc001wwd.3	+	14	2474	c.2375C>G	c.(2374-2376)TCA>TGA	p.S792*	FANCM_uc010anf.2_Nonsense_Mutation_p.S766*|FANCM_uc001wwe.3_Nonsense_Mutation_p.S328*|FANCM_uc010ang.2_Nonsense_Mutation_p.S6*	NM_020937	NP_065988	Q8IYD8	FANCM_HUMAN	Fanconi anemia, complementation group M	792					DNA repair	Fanconi anaemia nuclear complex	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding|nuclease activity|protein binding			ovary(3)|lung(2)|breast(2)	7						GATGTTACCTCAACATTTATT	0.328			NA						Involved_in_tolerance_or_repair_of_DNA_crosslinks	FanconAnemia				6	24					0	0	0.001984	0	0
NIN	51199	broad.mit.edu	37	14	51226916	51226916	+	Silent	SNP	G	G	C			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr14:51226916G>C	uc001wym.2	-	17	2249	c.2058C>G	c.(2056-2058)CTC>CTG	p.L686L	NIN_uc001wyi.2_Silent_p.L686L|NIN_uc001wyj.2_RNA|NIN_uc001wyk.2_Silent_p.L686L|NIN_uc010tqp.1_Silent_p.L692L|NIN_uc001wyo.2_Silent_p.L686L	NM_182946	NP_891991	Q8N4C6	NIN_HUMAN	ninein isoform 5	686	Potential.				centrosome localization	centrosome|microtubule	calcium ion binding|GTP binding|protein binding			skin(3)|ovary(1)|kidney(1)|central_nervous_system(1)	6	all_epithelial(31;0.00244)|Breast(41;0.127)					GTGCCTCCTTGAGCACTGCTG	0.458			NA	T	PDGFRB	MPD								7	178					0	0	0.001984	0	0
PTGER2	5732	broad.mit.edu	37	14	52781297	52781297	+	Missense_Mutation	SNP	G	G	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr14:52781297G>A	uc001wzr.2	+	1	282	c.31G>A	c.(31-33)GAG>AAG	p.E11K		NM_000956	NP_000947	P43116	PE2R2_HUMAN	prostaglandin E receptor 2 (subtype EP2), 53kDa	11	Extracellular (Potential).					integral to plasma membrane	prostaglandin E receptor activity			lung(1)|breast(1)	2	Breast(41;0.0639)|all_epithelial(31;0.0729)				Alprostadil(DB00770)|Iloprost(DB01088)	CTCCCAGTCTGAGGACTGCGA	0.627			NA											7	81					0	0	0.00308	0	0
DACT1	51339	broad.mit.edu	37	14	59112366	59112366	+	Missense_Mutation	SNP	T	T	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr14:59112366T>A	uc001xdw.2	+	4	1189	c.1025T>A	c.(1024-1026)ATT>AAT	p.I342N	DACT1_uc010trv.1_Missense_Mutation_p.I61N|DACT1_uc001xdx.2_Missense_Mutation_p.I305N|DACT1_uc010trw.1_Missense_Mutation_p.I61N	NM_016651	NP_057735	Q9NYF0	DACT1_HUMAN	dapper 1 isoform 1	342					multicellular organismal development|Wnt receptor signaling pathway	cytoplasm|nucleus				large_intestine(2)|lung(2)|ovary(1)	5						GATGGCTACATTCTGAGCCTG	0.517			NA											31	26					0	0	0.008361	0	0
MNAT1	4331	broad.mit.edu	37	14	61201638	61201638	+	Nonsense_Mutation	SNP	A	A	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr14:61201638A>T	uc001xfd.2	+	1	169	c.58A>T	c.(58-60)AAG>TAG	p.K20*	MNAT1_uc010apq.1_Nonsense_Mutation_p.K20*|MNAT1_uc001xfe.2_Nonsense_Mutation_p.K20*	NM_002431	NP_002422	P51948	MAT1_HUMAN	menage a trois 1 (CAK assembly factor)	20	RING-type.				cell proliferation|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|G2/M transition of mitotic cell cycle|mRNA capping|nucleotide-excision repair, DNA damage removal|positive regulation of transcription from RNA polymerase II promoter|positive regulation of viral transcription|protein complex assembly|protein phosphorylation|regulation of cyclin-dependent protein kinase activity|S phase of mitotic cell cycle|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase I promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	cytoplasm|holo TFIIH complex	protein N-terminus binding|zinc ion binding			ovary(1)|lung(1)	2				OV - Ovarian serous cystadenocarcinoma(108;0.0174)		CCCCTCCTTGAAGCTGATGGT	0.602			NA						Direct_reversal_of_damage|NER					12	74					0	0	0.010729	0	0
KIAA0247	9766	broad.mit.edu	37	14	70170156	70170156	+	Missense_Mutation	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr14:70170156C>T	uc001xlk.2	+	3	482	c.166C>T	c.(166-168)CAC>TAC	p.H56Y	KIAA0247_uc010aqz.2_Missense_Mutation_p.H31Y	NM_014734	NP_055549	Q92537	K0247_HUMAN	hypothetical protein LOC9766 precursor	56	Sushi.|Extracellular (Potential).					integral to membrane				ovary(3)	3				all cancers(60;0.00155)|BRCA - Breast invasive adenocarcinoma(234;0.0164)|OV - Ovarian serous cystadenocarcinoma(108;0.0196)		CTACATCTGCCACCCCCGGCC	0.572			NA											15	155					0	0	0.003163	0	0
MAP3K9	4293	broad.mit.edu	37	14	71199455	71199455	+	Missense_Mutation	SNP	G	G	C			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr14:71199455G>C	uc001xmm.2	-	11	2631	c.2631C>G	c.(2629-2631)CAC>CAG	p.H877Q	MAP3K9_uc010ttk.1_Missense_Mutation_p.H605Q|MAP3K9_uc001xmk.2_Missense_Mutation_p.H610Q|MAP3K9_uc001xml.2_Missense_Mutation_p.H891Q	NM_033141	NP_149132	P80192	M3K9_HUMAN	mitogen-activated protein kinase kinase kinase	877	Pro-rich.				activation of JUN kinase activity|protein autophosphorylation		ATP binding|JUN kinase kinase kinase activity|MAP kinase kinase activity|protein homodimerization activity			stomach(2)|lung(1)|central_nervous_system(1)|skin(1)	5				all cancers(60;0.00779)|BRCA - Breast invasive adenocarcinoma(234;0.00884)|OV - Ovarian serous cystadenocarcinoma(108;0.08)		CCAGGGGGTTGTGGGTACATG	0.592	GBM(114;411 1587 13539 28235 50070)		NA											4	169					0	0	0.000602	0	0
MAP3K9	4293	broad.mit.edu	37	14	71227747	71227747	+	Missense_Mutation	SNP	T	T	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr14:71227747T>A	uc001xmm.2	-	3	973	c.973A>T	c.(973-975)ATG>TTG	p.M325L	MAP3K9_uc010ttk.1_Missense_Mutation_p.M62L|MAP3K9_uc001xmk.2_Missense_Mutation_p.M19L|MAP3K9_uc001xml.2_Missense_Mutation_p.M325L	NM_033141	NP_149132	P80192	M3K9_HUMAN	mitogen-activated protein kinase kinase kinase	325	Protein kinase.				activation of JUN kinase activity|protein autophosphorylation		ATP binding|JUN kinase kinase kinase activity|MAP kinase kinase activity|protein homodimerization activity			stomach(2)|lung(1)|central_nervous_system(1)|skin(1)	5				all cancers(60;0.00779)|BRCA - Breast invasive adenocarcinoma(234;0.00884)|OV - Ovarian serous cystadenocarcinoma(108;0.08)		TTGGAAAACATGGAGGCCCGG	0.557	GBM(114;411 1587 13539 28235 50070)		NA											81	71					0	0	0.01441	0	0
DPF3	8110	broad.mit.edu	37	14	73190390	73190390	+	Missense_Mutation	SNP	T	T	C			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr14:73190390T>C	uc001xnc.2	-	5	489	c.476A>G	c.(475-477)GAG>GGG	p.E159G	DPF3_uc001xnd.1_RNA|DPF3_uc001xnf.2_RNA|DPF3_uc010ari.1_Missense_Mutation_p.E159G|DPF3_uc010ttq.1_Missense_Mutation_p.E169G	NM_012074	NP_036206	Q92784	DPF3_HUMAN	D4, zinc and double PHD fingers, family 3	159					chromatin modification|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nBAF complex	nucleic acid binding|zinc ion binding			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(234;0.00649)|OV - Ovarian serous cystadenocarcinoma(108;0.0654)		TTCCAAATCCTCTTCTTCATT	0.418			NA											116	115					0	0	0.01441	0	0
YLPM1	56252	broad.mit.edu	37	14	75265292	75265292	+	Nonsense_Mutation	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr14:75265292C>T	uc001xqj.3	+	5	3416	c.3292C>T	c.(3292-3294)CAA>TAA	p.Q1098*	YLPM1_uc001xql.3_RNA	NM_019589	NP_062535	P49750	YLPM1_HUMAN	YLP motif containing 1	903	Arg-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear speck				ovary(2)|pancreas(1)	3			KIRC - Kidney renal clear cell carcinoma(43;0.238)	BRCA - Breast invasive adenocarcinoma(234;0.00162)		AGGTGGTCTTCAAGGGAGCCA	0.602			NA											49	42					0	0	0.01441	0	0
NEK9	91754	broad.mit.edu	37	14	75563845	75563845	+	Missense_Mutation	SNP	G	G	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr14:75563845G>A	uc001xrl.2	-	17	2285	c.2131C>T	c.(2131-2133)CCG>TCG	p.P711S	NEK9_uc001xrk.2_Missense_Mutation_p.P211S	NM_033116	NP_149107	Q8TD19	NEK9_HUMAN	NIMA-related kinase 9	711	RCC1 6.				cell division|mitosis	mitochondrion|nucleus	ATP binding|metal ion binding|protein kinase binding|protein serine/threonine kinase activity			lung(2)|stomach(2)|ovary(1)	5				BRCA - Breast invasive adenocarcinoma(234;0.00718)		GACAGGTCCGGGACATGATGC	0.522			NA											10	83					0	0	0.006214	0	0
TTLL5	23093	broad.mit.edu	37	14	76211508	76211508	+	Missense_Mutation	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr14:76211508C>T	uc001xrx.2	+	16	1557	c.1352C>T	c.(1351-1353)CCA>CTA	p.P451L	TTLL5_uc010ask.1_Missense_Mutation_p.P465L|TTLL5_uc001xrz.2_Missense_Mutation_p.P13L|TTLL5_uc001xry.1_RNA	NM_015072	NP_055887	Q6EMB2	TTLL5_HUMAN	tubulin tyrosine ligase-like family, member 5	451					protein modification process|transcription, DNA-dependent	centrosome|cilium|microtubule basal body|nucleus	tubulin-tyrosine ligase activity			ovary(2)|central_nervous_system(1)	3				BRCA - Breast invasive adenocarcinoma(234;0.029)		GAGAAAGGGCCAGGGAAGTTG	0.453			NA											21	31					0	0	0.012319	0	0
TTLL5	23093	broad.mit.edu	37	14	76243112	76243112	+	Missense_Mutation	SNP	A	A	G			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr14:76243112A>G	uc001xrx.2	+	23	2511	c.2306A>G	c.(2305-2307)AAG>AGG	p.K769R	TTLL5_uc010ask.1_Missense_Mutation_p.K783R|TTLL5_uc001xrz.2_Missense_Mutation_p.K344R|TTLL5_uc001xry.1_RNA	NM_015072	NP_055887	Q6EMB2	TTLL5_HUMAN	tubulin tyrosine ligase-like family, member 5	769					protein modification process|transcription, DNA-dependent	centrosome|cilium|microtubule basal body|nucleus	tubulin-tyrosine ligase activity			ovary(2)|central_nervous_system(1)	3				BRCA - Breast invasive adenocarcinoma(234;0.029)		ATGGCTGAAAAGAAATCAAAG	0.378			NA											30	20					0	0	0.010818	0	0
ESRRB	2103	broad.mit.edu	37	14	76966335	76966335	+	Missense_Mutation	SNP	C	C	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr14:76966335C>A	uc001xsr.2	+	10	1797	c.1426C>A	c.(1426-1428)CGC>AGC	p.R476S	ESRRB_uc001xso.2_RNA	NM_004452	NP_004443	A2VDJ2	A2VDJ2_HUMAN	estrogen-related receptor beta	476						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			ovary(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(234;0.0213)		CCCCAATCCACGCCCTTCTAG	0.537			NA											9	4					0.00448238	0.00463893	0.004482	1	0
GPR65	8477	broad.mit.edu	37	14	88477258	88477258	+	Missense_Mutation	SNP	T	T	C			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr14:88477258T>C	uc001xvv.2	+	2	597	c.67T>C	c.(67-69)TTT>CTT	p.F23L		NM_003608	NP_003599	Q8IYL9	PSYR_HUMAN	G protein-coupled receptor 65	23	Helical; Name=1; (Potential).				actin cytoskeleton reorganization|activation of Rho GTPase activity|apoptosis|immune response|multicellular organismal development|positive regulation of cAMP biosynthetic process|positive regulation of stress fiber assembly|response to acidity	integral to plasma membrane	G-protein coupled receptor activity				0						TGTTTACATCTTTGTGATTAT	0.358			NA											3	39					0	0	0.004672	0	0
CPSF2	53981	broad.mit.edu	37	14	92609541	92609541	+	Missense_Mutation	SNP	A	A	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr14:92609541A>T	uc001yah.1	+	9	1280	c.1043A>T	c.(1042-1044)GAC>GTC	p.D348V		NM_017437	NP_059133	Q9P2I0	CPSF2_HUMAN	cleavage and polyadenylation specific factor 2	348					histone mRNA 3'-end processing|mRNA export from nucleus|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	mRNA cleavage and polyadenylation specificity factor complex	hydrolase activity|protein binding|RNA binding			ovary(2)	2		all_cancers(154;0.0766)		COAD - Colon adenocarcinoma(157;0.222)		TGGTGTCAGGACCCTAAAAAC	0.423	Ovarian(78;28 1788 18702 44111)		NA											5	22					0	0	0.000602	0	0
KIAA1409	57578	broad.mit.edu	37	14	94083525	94083525	+	Missense_Mutation	SNP	C	C	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr14:94083525C>A	uc001ybv.1	+	26	3717	c.3634C>A	c.(3634-3636)CTC>ATC	p.L1212I	KIAA1409_uc001ybs.1_Missense_Mutation_p.L1190I	NM_020818	NP_065869	Q9P2D8	UNC79_HUMAN	hypothetical protein LOC57578	1367						integral to membrane				ovary(10)|skin(4)|large_intestine(3)	17		all_cancers(154;0.0354)|all_epithelial(191;0.216)		Epithelial(152;0.188)		GGTTCAGGTGCTCAAATACTG	0.433			NA											12	54					1.61879e-10	1.99532e-10	0.013537	1	0
KIAA1409	57578	broad.mit.edu	37	14	94083609	94083609	+	Missense_Mutation	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr14:94083609C>T	uc001ybv.1	+	26	3801	c.3718C>T	c.(3718-3720)CGG>TGG	p.R1240W	KIAA1409_uc001ybs.1_Missense_Mutation_p.R1218W	NM_020818	NP_065869	Q9P2D8	UNC79_HUMAN	hypothetical protein LOC57578	1395						integral to membrane				ovary(10)|skin(4)|large_intestine(3)	17		all_cancers(154;0.0354)|all_epithelial(191;0.216)		Epithelial(152;0.188)		GCCTCACATCCGGCAGATGTG	0.502			NA											13	48					0	0	0.001855	0	0
SERPINA9	327657	broad.mit.edu	37	14	94936017	94936017	+	Missense_Mutation	SNP	C	C	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr14:94936017C>A	uc001ydf.2	-	2	376	c.215G>T	c.(214-216)CGC>CTC	p.R72L	SERPINA9_uc001yde.2_Missense_Mutation_p.R72L|SERPINA9_uc010avc.2_Intron|SERPINA9_uc001ydg.2_Intron|SERPINA9_uc001ydh.1_Missense_Mutation_p.R72L|SERPINA9_uc001ydi.1_Intron	NM_175739	NP_783866	Q86WD7	SPA9_HUMAN	serine (or cysteine) proteinase inhibitor, clade	54					regulation of proteolysis	cytoplasm|extracellular region|membrane	serine-type endopeptidase inhibitor activity			lung(1)|central_nervous_system(1)	2		all_cancers(154;0.0691)|all_epithelial(191;0.233)		Epithelial(152;0.144)|COAD - Colon adenocarcinoma(157;0.224)|all cancers(159;0.24)		GCGGTATAGGCGGAAGGCAAA	0.607			NA											18	54					2.94398e-08	3.5067e-08	0.007413	1	0
TCL6	27004	broad.mit.edu	37	14	96135898	96135899	+	Missense_Mutation	DNP	AG	AG	TT	rs76461999		TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	AG	AG	-	-	AG	AG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr14:96135898_96135899AG>TT	uc001yeq.2	+	5	1671_1672	c.202_203AG>TT	c.(202-204)AGG>TTG	p.R68L	TCL6_uc001yep.1_RNA|TCL6_uc001yes.2_3'UTR|TCL6_uc001yet.1_Missense_Mutation_p.R10L|TCL6_uc001yeu.2_3'UTR|TCL6_uc001yev.2_3'UTR|TCL1B_uc001yew.2_RNA|TCL1B_uc001yex.2_RNA|TCL1B_uc010avj.2_Intron|TCL6_uc010avk.1_5'Flank	NM_020554	NP_065579			SubName: Full=T-cell leukemia/lymphoma 6 ORF163;												0		all_cancers(154;0.103)		Epithelial(152;0.0655)|all cancers(159;0.149)|BRCA - Breast invasive adenocarcinoma(234;0.206)|COAD - Colon adenocarcinoma(157;0.207)		gttagaagcaaggcacaagtca	0.005			NA	T	TRA@	T-ALL								5	27					0	0	0.004672	0	0
BCL11B	64919	broad.mit.edu	37	14	99642483	99642483	+	Silent	SNP	G	G	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr14:99642483G>A	uc001yga.2	-	4	957	c.690C>T	c.(688-690)TTC>TTT	p.F230F	BCL11B_uc001ygb.2_Silent_p.F159F	NM_138576	NP_612808	Q9C0K0	BC11B_HUMAN	B-cell CLL/lymphoma 11B isoform 1	230	C2H2-type 1.					nucleus	zinc ion binding			central_nervous_system(8)|large_intestine(1)|lung(1)	10		Melanoma(154;0.0866)|all_epithelial(191;0.241)		COAD - Colon adenocarcinoma(157;0.103)		ACGCGCTGTTGAAGGGCTGCT	0.622			NA	T	TLX3	T-ALL								8	27					0	0	0.00308	0	0
AHNAK2	113146	broad.mit.edu	37	14	105408231	105408231	+	Silent	SNP	G	G	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr14:105408231G>A	uc010axc.1	-	7	13677	c.13557C>T	c.(13555-13557)GAC>GAT	p.D4519D	AHNAK2_uc001ypx.2_Silent_p.D4419D	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	4519						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			GGACCTCCAGGTCGGCGGAAG	0.622			NA											38	146					0	0	0.004289	0	0
AHNAK2	113146	broad.mit.edu	37	14	105416868	105416868	+	Silent	SNP	C	C	G			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr14:105416868C>G	uc010axc.1	-	7	5040	c.4920G>C	c.(4918-4920)CTG>CTC	p.L1640L	AHNAK2_uc001ypx.2_Silent_p.L1540L	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	1640						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			GGTCCCCCTCCAGCTGCGCAC	0.602			NA											58	239					0	0	0.01441	0	0
AHNAK2	113146	broad.mit.edu	37	14	105419147	105419147	+	Missense_Mutation	SNP	G	G	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr14:105419147G>T	uc010axc.1	-	7	2761	c.2641C>A	c.(2641-2643)CTC>ATC	p.L881I	AHNAK2_uc001ypx.2_Missense_Mutation_p.L781I	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	881						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			TGAATGCTGAGGTCAGTGGCC	0.652			NA											66	250					2.165e-29	3.01398e-29	0.01441	1	0
OR4M2	390538	broad.mit.edu	37	15	22369243	22369243	+	Missense_Mutation	SNP	C	C	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr15:22369243C>A	uc010tzu.1	+	1	668	c.668C>A	c.(667-669)GCC>GAC	p.A223D	LOC727924_uc001yua.2_Intron|LOC727924_uc001yub.1_Intron|OR4N4_uc001yuc.1_Intron	NM_001004719	NP_001004719	Q8NGB6	OR4M2_HUMAN	olfactory receptor, family 4, subfamily M,	223	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		all_cancers(20;1.94e-20)|all_epithelial(15;3.94e-18)|Lung NSC(15;8.53e-15)|all_lung(15;2.87e-14)|Breast(32;0.00519)|Colorectal(260;0.101)	GBM - Glioblastoma multiforme(6;0.124)	all cancers(64;1.64e-11)|Epithelial(43;5.81e-10)|BRCA - Breast invasive adenocarcinoma(123;0.000255)|Kidney(6;0.00736)|KIRC - Kidney renal clear cell carcinoma(6;0.0135)|GBM - Glioblastoma multiforme(186;0.0963)		TTCCTTCTGGCCTTGTTCAAG	0.478			NA											21	95					1.15919e-05	1.28779e-05	0.008871	1	0
GOLGA8DP	100132979	broad.mit.edu	37	15	22709206	22709206	+	Missense_Mutation	SNP	G	G	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr15:22709206G>A	uc010axw.2	-	11	1191	c.293C>T	c.(292-294)CCC>CTC	p.P98L	GOLGA8DP_uc010axx.2_Missense_Mutation_p.P98L|uc010tzw.1_5'Flank	NM_001012423	NP_001012423			golgi autoantigen, golgin subfamily a, 8E												0						CACCTCAGAGGGCACTGCTGG	0.493			NA											6	71					0	0	0.004482	0	0
TUBGCP5	114791	broad.mit.edu	37	15	22855270	22855270	+	Missense_Mutation	SNP	C	C	G			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr15:22855270C>G	uc001yur.3	+	13	1861	c.1731C>G	c.(1729-1731)AGC>AGG	p.S577R	TUBGCP5_uc001yuq.2_Missense_Mutation_p.S577R|TUBGCP5_uc010axz.1_Missense_Mutation_p.S164R	NM_052903	NP_443135	Q96RT8	GCP5_HUMAN	tubulin, gamma complex associated protein 5	577					G2/M transition of mitotic cell cycle|microtubule nucleation	centrosome|cytosol|gamma-tubulin ring complex|microtubule|spindle pole	microtubule binding			skin(1)	1		all_cancers(20;2.26e-25)|all_epithelial(15;2.1e-22)|Lung NSC(15;3.36e-17)|all_lung(15;1.04e-16)|Breast(32;0.000776)|Colorectal(260;0.0488)		all cancers(64;2.86e-06)|Epithelial(43;2.63e-05)|BRCA - Breast invasive adenocarcinoma(123;0.000949)		GTGCGGAGAGCACCACCTGCC	0.557			NA											4	20					0	0	0.009096	0	0
PLA2G4E	123745	broad.mit.edu	37	15	42285002	42285002	+	Missense_Mutation	SNP	T	T	C			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr15:42285002T>C	uc001zow.1	-	12	1316	c.1316A>G	c.(1315-1317)CAG>CGG	p.Q439R	PLA2G4E_uc010udc.1_5'UTR|PLA2G4E_uc001zov.1_Missense_Mutation_p.Q92R	NM_001080490	NP_001073959	Q3MJ16	PA24E_HUMAN	phospholipase A2, group 4E	456	PLA2c.				phospholipid catabolic process	cytosol|lysosomal membrane	metal ion binding|phospholipase A2 activity				0		all_cancers(109;8.09e-13)|all_epithelial(112;2.03e-11)|Lung NSC(122;2.17e-07)|all_lung(180;8.79e-07)|Melanoma(134;0.0273)		OV - Ovarian serous cystadenocarcinoma(18;7.61e-18)|GBM - Glioblastoma multiforme(94;3.07e-06)		GTAGCCTTCCTGGCTGCGCTG	0.607			NA											3	58					0	0	0.004672	0	0
DUOX2	50506	broad.mit.edu	37	15	45397883	45397883	+	Silent	SNP	C	C	G			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr15:45397883C>G	uc010bea.2	-	18	2495	c.2292G>C	c.(2290-2292)CGG>CGC	p.R764R	DUOX2_uc001zun.2_Silent_p.R764R	NM_014080	NP_054799	Q9NRD8	DUOX2_HUMAN	dual oxidase 2 precursor	764	Cytoplasmic (Potential).				cuticle development|cytokine-mediated signaling pathway|hormone biosynthetic process|hydrogen peroxide catabolic process|response to cAMP|response to virus	apical plasma membrane|integral to membrane	calcium ion binding|electron carrier activity|flavin adenine dinucleotide binding|heme binding|NAD(P)H oxidase activity|peroxidase activity			ovary(2)|skin(2)|pancreas(1)	5		all_cancers(109;3.79e-11)|all_epithelial(112;2.92e-09)|Lung NSC(122;3.55e-06)|all_lung(180;2.56e-05)|Melanoma(134;0.027)		all cancers(107;1.05e-18)|GBM - Glioblastoma multiforme(94;4.23e-07)|COAD - Colon adenocarcinoma(120;0.0668)|Colorectal(133;0.068)		GGATGCGTTCCCGCTGCTGCT	0.557			NA											39	61					0	0	0.005524	0	0
FBN1	2200	broad.mit.edu	37	15	48712914	48712914	+	Missense_Mutation	SNP	G	G	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr15:48712914G>A	uc001zwx.1	-	63	8117	c.7789C>T	c.(7789-7791)CTC>TTC	p.L2597F	FBN1_uc010beo.1_RNA	NM_000138	NP_000129	P35555	FBN1_HUMAN	fibrillin 1 precursor	2597	EGF-like 45; calcium-binding.				heart development|negative regulation of BMP signaling pathway by extracellular sequestering of BMP|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|skeletal system development	basement membrane|extracellular space|microfibril	calcium ion binding|extracellular matrix structural constituent|protein binding			ovary(2)|large_intestine(1)	3		all_lung(180;0.00279)		all cancers(107;4.24e-07)|GBM - Glioblastoma multiforme(94;1.41e-05)		TAGTGCTGGAGGTAGCCCTGG	0.527			NA											5	54					0	0	0.000602	0	0
FBN1	2200	broad.mit.edu	37	15	48805800	48805800	+	Missense_Mutation	SNP	T	T	G			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr15:48805800T>G	uc001zwx.1	-	13	1862	c.1534A>C	c.(1534-1536)ACC>CCC	p.T512P		NM_000138	NP_000129	P35555	FBN1_HUMAN	fibrillin 1 precursor	512	EGF-like 7; calcium-binding.				heart development|negative regulation of BMP signaling pathway by extracellular sequestering of BMP|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|skeletal system development	basement membrane|extracellular space|microfibril	calcium ion binding|extracellular matrix structural constituent|protein binding			ovary(2)|large_intestine(1)	3		all_lung(180;0.00279)		all cancers(107;4.24e-07)|GBM - Glioblastoma multiforme(94;1.41e-05)		CACTGACAGGTGTACGAACCC	0.473			NA											7	35					0	0	0.00308	0	0
CEP152	22995	broad.mit.edu	37	15	49059596	49059597	+	Missense_Mutation	DNP	CT	CT	TA			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	CT	CT	-	-	CT	CT	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr15:49059596_49059597CT>TA	uc001zwy.2	-	16	2116_2117	c.2082_2083AG>TA	c.(2080-2085)TTAGCA>TTTACA	p.694_695LA>FT	CEP152_uc001zwz.2_Missense_Mutation_p.694_695LA>FT|CEP152_uc001zxa.1_Missense_Mutation_p.601_602LA>FT	NM_014985	NP_055800	O94986	CE152_HUMAN	centrosomal protein 152kDa	694_695					centrosome duplication|G2/M transition of mitotic cell cycle	centrosome|cytosol	protein kinase binding			lung(2)	2		all_lung(180;0.0428)		all cancers(107;1.08e-07)|GBM - Glioblastoma multiforme(94;2.32e-06)		GCATGCTTTGCTAATAGGCTTT	0.436			NA											7	16					0	0	0.004672	0	0
GALK2	2585	broad.mit.edu	37	15	49611952	49611952	+	Silent	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr15:49611952C>T	uc001zxj.1	+	9	1217	c.1119C>T	c.(1117-1119)GAC>GAT	p.D373D	GALK2_uc001zxi.1_Silent_p.D362D|GALK2_uc010ufb.1_Silent_p.D349D|GALK2_uc001zxk.2_RNA|GALK2_uc010ufc.1_Silent_p.D349D	NM_002044	NP_002035	Q01415	GALK2_HUMAN	galactokinase 2 isoform 1	373					galactose metabolic process	cytoplasm	ATP binding|galactokinase activity|N-acetylgalactosamine kinase activity			breast(1)	1		all_lung(180;0.000325)		all cancers(107;3.71e-08)|GBM - Glioblastoma multiforme(94;7e-05)		GCTGCCGGGACATGTATGAGT	0.532			NA											9	22					0	0	0.006214	0	0
HDC	3067	broad.mit.edu	37	15	50534774	50534775	+	Missense_Mutation	DNP	GG	GG	TT			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr15:50534774_50534775GG>TT	uc001zxz.2	-	12	1777_1778	c.1671_1672CC>AA	c.(1669-1674)GCCCCA>GCAACA	p.P558T	HDC_uc001zxy.2_Missense_Mutation_p.P301T|HDC_uc010uff.1_Missense_Mutation_p.P525T	NM_002112	NP_002103	P19113	DCHS_HUMAN	histidine decarboxylase	558					catecholamine biosynthetic process|histidine metabolic process		histidine decarboxylase activity			large_intestine(2)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	6		all_lung(180;0.0138)		all cancers(107;1.12e-06)|GBM - Glioblastoma multiforme(94;9.95e-05)	L-Histidine(DB00117)|Pyridoxal Phosphate(DB00114)	GTGGCATCTGGGGCCTCTTCTG	0.545	GBM(95;1627 1936 6910 9570)		NA											50	109					0	0	0.004672	0	0
HDC	3067	broad.mit.edu	37	15	50540459	50540459	+	Missense_Mutation	SNP	G	G	C			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr15:50540459G>C	uc001zxz.2	-	10	1229	c.1123C>G	c.(1123-1125)CAA>GAA	p.Q375E	HDC_uc001zxy.2_Missense_Mutation_p.Q118E|HDC_uc010uff.1_Intron	NM_002112	NP_002103	P19113	DCHS_HUMAN	histidine decarboxylase	375					catecholamine biosynthetic process|histidine metabolic process		histidine decarboxylase activity			large_intestine(2)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	6		all_lung(180;0.0138)		all cancers(107;1.12e-06)|GBM - Glioblastoma multiforme(94;9.95e-05)	L-Histidine(DB00117)|Pyridoxal Phosphate(DB00114)	ACATGTGCTTGAAGATTCTTC	0.507	GBM(95;1627 1936 6910 9570)		NA											5	11					0	0	0.001168	0	0
HDC	3067	broad.mit.edu	37	15	50555455	50555455	+	Missense_Mutation	SNP	T	T	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr15:50555455T>A	uc001zxz.2	-	2	287	c.181A>T	c.(181-183)ATT>TTT	p.I61F	HDC_uc010uff.1_Missense_Mutation_p.I61F|HDC_uc010bet.1_Missense_Mutation_p.I61F|HDC_uc010beu.1_Missense_Mutation_p.I61F	NM_002112	NP_002103	P19113	DCHS_HUMAN	histidine decarboxylase	61					catecholamine biosynthetic process|histidine metabolic process		histidine decarboxylase activity			large_intestine(2)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	6		all_lung(180;0.0138)		all cancers(107;1.12e-06)|GBM - Glioblastoma multiforme(94;9.95e-05)	L-Histidine(DB00117)|Pyridoxal Phosphate(DB00114)	ATTCGTTCAATGTCCCCAAAG	0.597	GBM(95;1627 1936 6910 9570)		NA											50	138					0	0	0.01441	0	0
LYSMD2	256586	broad.mit.edu	37	15	52017224	52017224	+	Missense_Mutation	SNP	A	A	G			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr15:52017224A>G	uc002abi.2	-	2	869	c.368T>C	c.(367-369)TTG>TCG	p.L123S	LYSMD2_uc002abj.2_Missense_Mutation_p.L32S	NM_153374	NP_699205	Q8IV50	LYSM2_HUMAN	LysM, putative peptidoglycan-binding, domain	123					cell wall macromolecule catabolic process						0				all cancers(107;0.00258)		ATTAAACAACAAAGGCTTCTC	0.383			NA											11	26					0	0	0.008291	0	0
TEX9	374618	broad.mit.edu	37	15	56681599	56681599	+	Splice_Site	SNP	G	G	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr15:56681599G>A	uc002adp.2	+	6	400	c.395_splice	c.e6+1	p.S132_splice	TEX9_uc002ado.1_Splice_Site_p.S132_splice|TEX9_uc010ugl.1_Splice_Site_p.S57_splice|TEX9_uc002adq.1_Splice_Site_p.S57_splice	NM_198524	NP_940926	Q8N6V9	TEX9_HUMAN	testis expressed 9												0				all cancers(107;0.0394)|GBM - Glioblastoma multiforme(80;0.056)		CAAATTCAAGGTATAGTATAG	0.274			NA											3	5					0	0	0.004672	0	0
ADAM10	102	broad.mit.edu	37	15	58957351	58957351	+	Nonsense_Mutation	SNP	G	G	C			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr15:58957351G>C	uc002afd.1	-	5	974	c.530C>G	c.(529-531)TCA>TGA	p.S177*	ADAM10_uc010bgc.1_RNA|ADAM10_uc010ugz.1_Intron|ADAM10_uc002afe.1_Intron|ADAM10_uc002afg.2_Nonsense_Mutation_p.S177*	NM_001110	NP_001101	O14672	ADA10_HUMAN	ADAM metallopeptidase domain 10 precursor	177	Cysteine switch (By similarity).|Extracellular (Potential).				cell-cell signaling|constitutive protein ectodomain proteolysis|epidermal growth factor receptor signaling pathway|in utero embryonic development|integrin-mediated signaling pathway|monocyte activation|negative regulation of cell adhesion|Notch receptor processing|Notch signaling pathway|PMA-inducible membrane protein ectodomain proteolysis|positive regulation of cell growth|positive regulation of cell proliferation|positive regulation of T cell chemotaxis|protein phosphorylation|response to tumor necrosis factor	cell surface|endomembrane system|Golgi-associated vesicle|integral to membrane|nucleus|plasma membrane	integrin binding|metalloendopeptidase activity|protein homodimerization activity|protein kinase binding|SH3 domain binding|zinc ion binding			skin(2)	2				GBM - Glioblastoma multiforme(80;0.202)		TTCAAATACTGAATGATCTGC	0.368			NA											6	42					0	0	0.001168	0	0
VPS13C	54832	broad.mit.edu	37	15	62212764	62212764	+	Missense_Mutation	SNP	G	G	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr15:62212764G>T	uc002agz.2	-	56	7219	c.7145C>A	c.(7144-7146)TCT>TAT	p.S2382Y	VPS13C_uc002aha.2_Missense_Mutation_p.S2339Y|VPS13C_uc002ahb.1_Missense_Mutation_p.S2382Y|VPS13C_uc002ahc.1_Missense_Mutation_p.S2339Y|VPS13C_uc002ahd.1_5'Flank	NM_020821	NP_065872	Q709C8	VP13C_HUMAN	vacuolar protein sorting 13C protein isoform 2A	2382					protein localization					ovary(2)	2						ATTTCCTGAAGAAATATGAAT	0.308			NA											3	13					6.4e-05	6.95722e-05	0.004672	1	0
IGDCC4	57722	broad.mit.edu	37	15	65676637	65676637	+	Missense_Mutation	SNP	G	G	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr15:65676637G>T	uc002aou.1	-	20	3673	c.3463C>A	c.(3463-3465)CCT>ACT	p.P1155T	IGDCC4_uc002aot.1_Missense_Mutation_p.P743T	NM_020962	NP_066013	Q8TDY8	IGDC4_HUMAN	immunoglobulin superfamily, DCC subclass, member	1155	Cytoplasmic (Potential).					integral to membrane|plasma membrane				ovary(1)|pancreas(1)|skin(1)	3						GGGTCCTCAGGCTCCAGGTCT	0.612			NA											19	60					8.28177e-16	1.08825e-15	0.007413	1	0
TLE3	7090	broad.mit.edu	37	15	70342515	70342515	+	Missense_Mutation	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr15:70342515C>T	uc002asm.2	-	20	3359	c.2240G>A	c.(2239-2241)TGT>TAT	p.C747Y	TLE3_uc002ask.2_Missense_Mutation_p.C674Y|TLE3_uc002asl.2_Missense_Mutation_p.C747Y|TLE3_uc010ukd.1_Missense_Mutation_p.C737Y|TLE3_uc010bik.1_Missense_Mutation_p.C328Y|TLE3_uc010bil.1_Missense_Mutation_p.C744Y|TLE3_uc002asn.2_Missense_Mutation_p.C735Y|TLE3_uc002asp.2_Missense_Mutation_p.C739Y|TLE3_uc002aso.2_Missense_Mutation_p.C742Y	NM_005078	NP_005069	Q04726	TLE3_HUMAN	transducin-like enhancer protein 3 isoform a	747	WD 7.				organ morphogenesis|regulation of transcription, DNA-dependent|transcription, DNA-dependent|Wnt receptor signaling pathway	nucleus	protein binding|protein binding			lung(2)	2						TGAAATGTCACAACTCAAGAC	0.473			NA											32	79					0	0	0.013726	0	0
MYO9A	4649	broad.mit.edu	37	15	72122611	72122611	+	Silent	SNP	C	C	A	rs146276674	byFrequency	TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr15:72122611C>A	uc002atl.3	-	40	7352	c.6879G>T	c.(6877-6879)TCG>TCT	p.S2293S	MYO9A_uc002atj.2_Silent_p.S224S|MYO9A_uc002atk.2_Silent_p.S1088S	NM_006901	NP_008832	B2RTY4	MYO9A_HUMAN	myosin IXA	2293	Tail.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction|visual perception	cytosol|integral to membrane|unconventional myosin complex	actin binding|ATP binding|GTPase activator activity|metal ion binding|motor activity			ovary(1)|pancreas(1)|skin(1)	3						CAACAGGAGACGATGGACCTG	0.468			NA											3	45					6.4e-05	6.95722e-05	0.004672	1	0
CD276	80381	broad.mit.edu	37	15	73991925	73991925	+	Splice_Site	SNP	A	A	G			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr15:73991925A>G	uc002avv.1	+	2	181	c.-53_splice	c.e2-2		CD276_uc010bjd.1_Intron|CD276_uc002avu.1_Splice_Site|CD276_uc002avw.1_Splice_Site|CD276_uc010ulb.1_Splice_Site	NM_001024736	NP_001019907	Q5ZPR3	CD276_HUMAN	CD276 antigen isoform a						cell proliferation|immune response|positive regulation of interferon-gamma biosynthetic process|positive regulation of T cell proliferation|regulation of immune response|T cell activation	external side of plasma membrane|integral to membrane	receptor binding			skin(1)	1						TCTTTCTCCCAGGCAGGGGCA	0.637			NA											3	12					0	0	0.004672	0	0
CYP1A1	1543	broad.mit.edu	37	15	75014861	75014861	+	Missense_Mutation	SNP	G	G	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr15:75014861G>A	uc002ayp.3	-	2	700	c.578C>T	c.(577-579)TCA>TTA	p.S193L	CYP1A1_uc010bjv.2_Intron|CYP1A1_uc010bjw.2_Intron|CYP1A1_uc010bju.2_5'UTR|CYP1A1_uc010bjx.2_Intron|CYP1A1_uc002ayq.3_Missense_Mutation_p.S193L|CYP1A1_uc010bjy.2_Missense_Mutation_p.S193L|CYP1A1_uc010bjz.1_5'UTR	NM_000499	NP_000490	P04798	CP1A1_HUMAN	cytochrome P450, family 1, subfamily A,	193					cellular lipid metabolic process|drug metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding|vitamin D 24-hydroxylase activity			ovary(2)|breast(2)|pancreas(1)	5					Arsenic trioxide(DB01169)|Benzphetamine(DB00865)|Bleomycin(DB00290)|Chlorzoxazone(DB00356)|Dacarbazine(DB00851)|Dactinomycin(DB00970)|Esomeprazole(DB00736)|Estrone(DB00655)|Fluvastatin(DB01095)|Fluvoxamine(DB00176)|Ginseng(DB01404)|Granisetron(DB00889)|Ketoconazole(DB01026)|Menadione(DB00170)|Picrotoxin(DB00466)|Primaquine(DB01087)|Quinidine(DB00908)|Quinine(DB00468)|Thiabendazole(DB00730)	ATTGGTCACTGATACCACCAC	0.517			NA							Endometrial_Cancer_Familial_Clustering_of|ACTH-independent_macronodular_adrenal_hyperplasia				28	59					0	0	0.00632	0	0
CYP1A1	1543	broad.mit.edu	37	15	75014929	75014929	+	Silent	SNP	C	C	G			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr15:75014929C>G	uc002ayp.3	-	2	632	c.510G>C	c.(508-510)CTG>CTC	p.L170L	CYP1A1_uc010bjv.2_RNA|CYP1A1_uc010bjw.2_RNA|CYP1A1_uc010bju.2_Intron|CYP1A1_uc010bjx.2_Intron|CYP1A1_uc002ayq.3_Silent_p.L170L|CYP1A1_uc010bjy.2_Silent_p.L170L|CYP1A1_uc010bjz.1_Intron	NM_000499	NP_000490	P04798	CP1A1_HUMAN	cytochrome P450, family 1, subfamily A,	170					cellular lipid metabolic process|drug metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding|vitamin D 24-hydroxylase activity			ovary(2)|breast(2)|pancreas(1)	5					Arsenic trioxide(DB01169)|Benzphetamine(DB00865)|Bleomycin(DB00290)|Chlorzoxazone(DB00356)|Dacarbazine(DB00851)|Dactinomycin(DB00970)|Esomeprazole(DB00736)|Estrone(DB00655)|Fluvastatin(DB01095)|Fluvoxamine(DB00176)|Ginseng(DB01404)|Granisetron(DB00889)|Ketoconazole(DB01026)|Menadione(DB00170)|Picrotoxin(DB00466)|Primaquine(DB01087)|Quinidine(DB00908)|Quinine(DB00468)|Thiabendazole(DB00730)	ACGTGCTTATCAGGACCTCAG	0.537			NA							Endometrial_Cancer_Familial_Clustering_of|ACTH-independent_macronodular_adrenal_hyperplasia				25	88					0	0	0.00333	0	0
MEX3B	84206	broad.mit.edu	37	15	82336941	82336941	+	Missense_Mutation	SNP	T	T	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr15:82336941T>A	uc002bgq.1	-	2	585	c.270A>T	c.(268-270)AAA>AAT	p.K90N		NM_032246	NP_115622	Q6ZN04	MEX3B_HUMAN	mex-3 homolog B	90	KH 1.				protein autophosphorylation	cytoplasmic mRNA processing body|nucleus	calcium ion binding|RNA binding|zinc ion binding			breast(1)|kidney(1)	2						CCCGCAGCGCTTTGATTTTAC	0.597			NA											15	35					0	0	0.003163	0	0
AP3B2	8120	broad.mit.edu	37	15	83332601	83332601	+	Silent	SNP	C	C	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr15:83332601C>A	uc010uoh.1	-	19	2508	c.2331G>T	c.(2329-2331)TCG>TCT	p.S777S	AP3B2_uc010uoi.1_Silent_p.S796S|AP3B2_uc010uoj.1_Silent_p.S745S|AP3B2_uc010bmp.2_5'Flank|AP3B2_uc010uog.1_Silent_p.S413S|AP3B2_uc002biy.1_5'Flank	NM_004644	NP_004635	Q13367	AP3B2_HUMAN	adaptor-related protein complex 3, beta 2	777	Glu/Ser-rich.				endocytosis|intracellular protein transport|post-Golgi vesicle-mediated transport	clathrin coated vesicle membrane|COPI-coated vesicle|membrane coat	binding|protein transporter activity			ovary(3)|breast(1)|pancreas(1)	5			BRCA - Breast invasive adenocarcinoma(143;0.229)			CCTCGGACTCCGATGTCATCT	0.572			NA											15	25					1.3612e-06	1.55873e-06	0.003163	1	0
ISG20	3669	broad.mit.edu	37	15	89198743	89198743	+	Missense_Mutation	SNP	G	G	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr15:89198743G>A	uc002bmv.1	+	4	820	c.527G>A	c.(526-528)CGC>CAC	p.R176H	ISG20_uc002bmu.1_RNA|ISG20_uc002bmw.1_RNA|ISG20_uc010upn.1_RNA	NM_002201	NP_002192	Q96AZ6	ISG20_HUMAN	interferon stimulated exonuclease	176					cell proliferation|DNA catabolic process, exonucleolytic|response to virus|RNA catabolic process|type I interferon-mediated signaling pathway	PML body	3'-5'-exoribonuclease activity|exoribonuclease II activity|metal ion binding|RNA binding|single-stranded DNA specific 3'-5' exodeoxyribonuclease activity				0	Lung NSC(78;0.0554)|all_lung(78;0.103)		BRCA - Breast invasive adenocarcinoma(143;0.12)			GGGCTGCCCCGCCTGGCTGTG	0.572			NA											19	64					0	0	0.008871	0	0
MFGE8	4240	broad.mit.edu	37	15	89449995	89449995	+	Silent	SNP	C	C	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr15:89449995C>A	uc002bng.3	-	4	515	c.402G>T	c.(400-402)CGG>CGT	p.R134R	MFGE8_uc002bnf.3_Silent_p.R22R|MFGE8_uc002bnh.3_Silent_p.R134R|MFGE8_uc010bnn.2_Silent_p.R126R|MFGE8_uc010upq.1_Silent_p.R90R|MFGE8_uc010upr.1_Silent_p.R134R|MFGE8_uc010bno.2_Silent_p.R90R	NM_005928	NP_005919	Q08431	MFGM_HUMAN	milk fat globule-EGF factor 8 protein isoform a	134	F5/8 type C 1.				angiogenesis|cell adhesion|interspecies interaction between organisms|single fertilization					ovary(1)	1	Lung NSC(78;0.0392)|all_lung(78;0.077)					CCCACATCCTCCGCAGCAGGT	0.587			NA											23	51					1.66031e-10	2.04129e-10	0.003954	1	0
RHCG	51458	broad.mit.edu	37	15	90020012	90020012	+	Missense_Mutation	SNP	A	A	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr15:90020012A>T	uc002bnz.2	-	9	1309	c.1285T>A	c.(1285-1287)TGC>AGC	p.C429S	RHCG_uc002bny.2_Missense_Mutation_p.C200S|RHCG_uc002boa.2_RNA	NM_016321	NP_057405	Q9UBD6	RHCG_HUMAN	Rh family, C glycoprotein	429	Cytoplasmic (Potential).				amine transport|cellular ion homeostasis|epithelial cell differentiation|transepithelial ammonium transport	apical plasma membrane|basolateral plasma membrane|cytoplasmic vesicle|integral to plasma membrane	ammonia transmembrane transporter activity|ammonium transmembrane transporter activity|ankyrin binding			kidney(1)	1	Lung NSC(78;0.0237)|all_lung(78;0.0478)					TCCTCAAAGCAGTTCTCATCT	0.547			NA											15	37					0	0	0.004007	0	0
ANPEP	290	broad.mit.edu	37	15	90346962	90346962	+	Silent	SNP	G	G	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr15:90346962G>A	uc002bop.3	-	8	1645	c.1353C>T	c.(1351-1353)TCC>TCT	p.S451S		NM_001150	NP_001141	P15144	AMPN_HUMAN	membrane alanine aminopeptidase precursor	451	Extracellular.|Metalloprotease.				angiogenesis|cell differentiation|interspecies interaction between organisms	cytosol|ER-Golgi intermediate compartment|integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|receptor activity|zinc ion binding			ovary(3)|skin(1)	4	Lung NSC(78;0.0221)|all_lung(78;0.0448)		BRCA - Breast invasive adenocarcinoma(143;0.0146)|KIRC - Kidney renal clear cell carcinoma(17;0.0286)|Kidney(142;0.0514)|STAD - Stomach adenocarcinoma(125;0.169)		Ezetimibe(DB00973)	GCGGGTGGGAGGAGGCCAGTG	0.607	NSCLC(30;827 977 2459 19669 26125)		NA											20	59					0	0	0.012319	0	0
ADAMTS17	170691	broad.mit.edu	37	15	100802561	100802561	+	Missense_Mutation	SNP	C	C	G			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr15:100802561C>G	uc002bvv.1	-	5	948	c.869G>C	c.(868-870)CGT>CCT	p.R290P	ADAMTS17_uc002bvx.1_Missense_Mutation_p.R47P	NM_139057	NP_620688	Q8TE56	ATS17_HUMAN	ADAM metallopeptidase with thrombospondin type 1	290	Peptidase M12B.				proteolysis	intracellular|proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(2)|central_nervous_system(1)	3	Lung NSC(78;0.00299)|all_lung(78;0.00457)|Melanoma(26;0.00571)		OV - Ovarian serous cystadenocarcinoma(32;0.0013)|LUSC - Lung squamous cell carcinoma(107;0.132)|Lung(145;0.161)	COAD - Colon adenocarcinoma(1;0.111)|all cancers(203;0.219)		ACTTACGGGACGTTGTCGTAG	0.473			NA											15	105					0	0	0.00499	0	0
AXIN1	8312	broad.mit.edu	37	16	347741	347741	+	Missense_Mutation	SNP	T	T	C			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr16:347741T>C	uc002cgp.1	-	6	1942	c.1765A>G	c.(1765-1767)AGT>GGT	p.S589G	AXIN1_uc002cgq.1_Missense_Mutation_p.S589G	NM_003502	NP_003493	O15169	AXIN1_HUMAN	axin 1 isoform a	589	Interaction with RNF111.|Interaction with PPP2CA.				activation of JUN kinase activity|activation of protein kinase activity|apoptosis|axial mesoderm formation|canonical Wnt receptor signaling pathway involved in neural plate anterior/posterior pattern formation|cellular protein complex assembly|cellular response to organic cyclic compound|cytoplasmic microtubule organization|determination of left/right symmetry|dorsal/ventral axis specification|embryonic eye morphogenesis|embryonic skeletal joint morphogenesis|forebrain anterior/posterior pattern formation|muscle cell development|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of fat cell differentiation|olfactory placode formation|optic placode formation|positive regulation of JNK cascade|positive regulation of peptidyl-serine phosphorylation|positive regulation of peptidyl-threonine phosphorylation|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of transcription, DNA-dependent|positive regulation of ubiquitin-protein ligase activity|regulation of catenin import into nucleus|tail morphogenesis|Wnt receptor signaling pathway involved in forebrain neuron fate commitment|Wnt receptor signaling pathway involved in somitogenesis	APC-Axin-1-beta-catenin complex|Axin-APC-beta-catenin-GSK3B complex|beta-catenin destruction complex|cell cortex|cytoplasmic membrane-bounded vesicle|cytoplasmic microtubule|cytosol|lateral plasma membrane|nucleus|perinuclear region of cytoplasm|postsynaptic density	armadillo repeat domain binding|beta-catenin binding|GTPase activator activity|I-SMAD binding|p53 binding|protein complex scaffold|protein homodimerization activity|protein kinase binding|signal transducer activity|ubiquitin protein ligase binding			breast(1)|liver(1)	2		all_cancers(16;2.75e-07)|all_epithelial(16;1.6e-06)|Hepatocellular(16;0.000105)|Lung NSC(18;0.00774)|all_lung(18;0.0187)				AGGCCATCACTGGCGTTGGGG	0.652			NA											8	19					0	0	0.004482	0	0
WDR90	197335	broad.mit.edu	37	16	706405	706405	+	Silent	SNP	G	G	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr16:706405G>T	uc002cii.1	+	18	2124	c.2070G>T	c.(2068-2070)CGG>CGT	p.R690R	WDR90_uc002cig.1_3'UTR|WDR90_uc002cih.1_3'UTR|WDR90_uc002cij.1_Intron|WDR90_uc002cik.1_Silent_p.R217R|WDR90_uc002cil.1_5'Flank|WDR90_uc002cim.1_5'Flank	NM_145294	NP_660337	Q96KV7	WDR90_HUMAN	WD repeat domain 90	690	WD 5.									ovary(1)	1		Hepatocellular(780;0.0218)				CGCTGTCCCGGGTGTACCACA	0.697			NA											6	19					0.00116845	0.00122497	0.001168	1	0
CCDC78	124093	broad.mit.edu	37	16	773113	773113	+	Missense_Mutation	SNP	G	G	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr16:773113G>T	uc002cjg.2	-	12	1288	c.1182C>A	c.(1180-1182)GAC>GAA	p.D394E	CCDC78_uc002cjf.2_Missense_Mutation_p.D243E|CCDC78_uc002cji.3_3'UTR|CCDC78_uc002cjj.3_3'UTR|CCDC78_uc002cjh.2_Missense_Mutation_p.D153E	NM_001031737	NP_001026907	A2IDD5	CCD78_HUMAN	coiled-coil domain containing 78	394										central_nervous_system(1)	1		Hepatocellular(780;0.0218)				TGCGGGAGAAGTCCCGGAGCT	0.642			NA											8	39					1.12685e-05	1.25378e-05	0.004482	1	0
TPSD1	23430	broad.mit.edu	37	16	1306299	1306299	+	Silent	SNP	C	C	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr16:1306299C>A	uc002clb.1	+	1	27	c.18C>A	c.(16-18)CCC>CCA	p.P6P	TPSD1_uc010brm.1_5'Flank	NM_012217	NP_036349	Q9BZJ3	TRYD_HUMAN	tryptase delta 1 precursor	6					proteolysis	extracellular region	serine-type endopeptidase activity				0		Hepatocellular(780;0.00369)				TCCTTGCTCCCCAGATGCTGA	0.711			NA											22	77					1.64293e-13	2.1111e-13	0.00333	1	0
IFT140	9742	broad.mit.edu	37	16	1652541	1652541	+	Silent	SNP	G	G	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr16:1652541G>A	uc002cmb.2	-	4	561	c.199C>T	c.(199-201)CTG>TTG	p.L67L		NM_014714	NP_055529	Q96RY7	IF140_HUMAN	intraflagellar transport 140	67	WD 2.									ovary(3)|pancreas(1)|skin(1)	5		Hepatocellular(780;0.219)				TGCCAGCACAGGGAAGCAACC	0.602			NA											6	44					0	0	0.001984	0	0
PKD1	5310	broad.mit.edu	37	16	2159683	2159684	+	Missense_Mutation	DNP	GC	GC	AA			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	GC	GC	-	-	GC	GC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr16:2159683_2159684GC>AA	uc002cos.1	-	15	5693_5694	c.5484_5485GC>TT	c.(5482-5487)CAGCTG>CATTTG	p.Q1828H	PKD1_uc002cot.1_Missense_Mutation_p.Q1828H	NM_001009944	NP_001009944	P98161	PKD1_HUMAN	polycystin 1 isoform 1 precursor	1828	PKD 14.|Extracellular (Potential).				calcium-independent cell-matrix adhesion|homophilic cell adhesion|neuropeptide signaling pathway	basolateral plasma membrane|integral to plasma membrane	protein domain specific binding|sugar binding			central_nervous_system(2)|skin(1)	3						CCCGTGGCCAGCTGCCCCCAAA	0.668			NA											3	8					0	0	0.004672	0	0
PKD1	5310	broad.mit.edu	37	16	2164413	2164413	+	Nonsense_Mutation	SNP	C	C	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr16:2164413C>A	uc002cos.1	-	11	2820	c.2611G>T	c.(2611-2613)GAG>TAG	p.E871*	PKD1_uc002cot.1_Nonsense_Mutation_p.E871*	NM_001009944	NP_001009944	P98161	PKD1_HUMAN	polycystin 1 isoform 1 precursor	871	Extracellular (Potential).|PKD 3.				calcium-independent cell-matrix adhesion|homophilic cell adhesion|neuropeptide signaling pathway	basolateral plasma membrane|integral to plasma membrane	protein domain specific binding|sugar binding			central_nervous_system(2)|skin(1)	3						CAGACATTCTCAAAGCGGGCG	0.667			NA											8	26					0.00448238	0.00463893	0.004482	1	0
MEFV	4210	broad.mit.edu	37	16	3294475	3294475	+	Nonsense_Mutation	SNP	G	G	C			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr16:3294475G>C	uc002cun.1	-	7	1764	c.1724C>G	c.(1723-1725)TCA>TGA	p.S575*		NM_000243	NP_000234	O15553	MEFV_HUMAN	Mediterranean fever protein	575					inflammatory response	cytoplasm|microtubule|microtubule associated complex|nucleus	actin binding|zinc ion binding			central_nervous_system(2)|skin(2)|ovary(1)|lung(1)	6					Colchicine(DB01394)	CCATCTACCTGAGAAGTACTT	0.507			NA											18	81					0	0	0.006122	0	0
ZNF75A	7627	broad.mit.edu	37	16	3367374	3367374	+	Missense_Mutation	SNP	G	G	C			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr16:3367374G>C	uc002cut.3	+	6	922	c.396G>C	c.(394-396)AAG>AAC	p.K132N	ZNF75A_uc002cuv.3_RNA	NM_153028	NP_694573	Q96N20	ZN75A_HUMAN	zinc finger protein 75a	132					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)	1						TTCCAGTGAAGAAAAGAAAGA	0.383			NA											5	21					0	0	0.000602	0	0
ZNF500	26048	broad.mit.edu	37	16	4802892	4802892	+	Missense_Mutation	SNP	C	C	A	rs75619376	byFrequency	TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr16:4802892C>A	uc002cxp.1	-	6	1175	c.928G>T	c.(928-930)GGC>TGC	p.G310C	ZNF500_uc002cxo.1_Missense_Mutation_p.G102C|ZNF500_uc010uxt.1_Missense_Mutation_p.G310C	NM_021646	NP_067678	O60304	ZN500_HUMAN	zinc finger protein 500	310					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)|skin(1)	3						GGTGGGGGGCCGCCTCTTGGC	0.662			NA											18	68					1.99824e-07	2.3286e-07	0.00499	1	0
CLEC16A	23274	broad.mit.edu	37	16	11133706	11133706	+	Missense_Mutation	SNP	A	A	G			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr16:11133706A>G	uc002dao.2	+	14	1863	c.1633A>G	c.(1633-1635)AGG>GGG	p.R545G	CLEC16A_uc002dan.3_Missense_Mutation_p.R527G	NM_015226	NP_056041	Q2KHT3	CL16A_HUMAN	C-type lectin domain family 16, member A	545								p.0?(1)		ovary(1)|central_nervous_system(1)	2						AAGACTCATCAGGATCATGAA	0.577			NA											5	8					0	0	0.001168	0	0
PLA2G10	8399	broad.mit.edu	37	16	14766512	14766512	+	Silent	SNP	G	G	C			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr16:14766512G>C	uc002dcq.2	-	4	890	c.450C>G	c.(448-450)CTC>CTG	p.L150L		NM_003561	NP_003552	O15496	PA2GX_HUMAN	phospholipase A2, group X precursor	150					arachidonic acid metabolic process|axon guidance|cholesterol homeostasis|lipid catabolic process|lysophospholipid transport|negative regulation of cholesterol efflux|negative regulation of sequence-specific DNA binding transcription factor activity|phospholipid metabolic process|positive regulation of arachidonic acid secretion|positive regulation of cellular protein metabolic process|positive regulation of lipid storage|positive regulation of prostaglandin secretion|regulation of macrophage activation	extracellular region	calcium ion binding|phospholipase A2 activity				0						GGGGGTAGAAGAGGTACTTTA	0.478			NA											34	168					0	0	0.012213	0	0
Unknown	0	broad.mit.edu	37	16	15023240	15023240	+	Missense_Mutation	SNP	G	G	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr16:15023240G>T	uc010uzk.1	+	6	1085	c.809G>T	c.(808-810)CGC>CTC	p.R270L	NPIP_uc002dcx.3_RNA					SubName: Full=cDNA FLJ57488, highly similar to Polycystin-1;												NA						ATCCTCACGCGCTCCCGCGTG	0.701			NA											4	26					0.00024832	0.000265313	0.009096	1	0
SMG1	23049	broad.mit.edu	37	16	18856973	18856973	+	Silent	SNP	T	T	C			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr16:18856973T>C	uc002dfm.2	-	39	6360	c.5997A>G	c.(5995-5997)AAA>AAG	p.K1999K	SMG1_uc010bwb.2_Silent_p.K1859K|SMG1_uc010bwa.2_Silent_p.K730K|SMG1_uc002dfo.3_Silent_p.K297K	NM_015092	NP_055907	Q96Q15	SMG1_HUMAN	PI-3-kinase-related kinase SMG-1	1999					DNA repair|mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|peptidyl-serine phosphorylation|phosphatidylinositol phosphorylation|protein autophosphorylation	cytoplasm|nucleus	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			breast(5)|stomach(4)|lung(4)|kidney(2)|ovary(1)	16						TTTTCTCTTCTCTGACCAAGA	0.363			NA											8	44					0	0	0.00308	0	0
ACSM2A	123876	broad.mit.edu	37	16	20486733	20486733	+	Missense_Mutation	SNP	A	A	C			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr16:20486733A>C	uc010bwe.2	+	8	1183	c.944A>C	c.(943-945)TAC>TCC	p.Y315S	ACSM2A_uc010bwd.1_RNA|ACSM2A_uc010vax.1_Missense_Mutation_p.Y236S|ACSM2A_uc002dhf.3_Missense_Mutation_p.Y315S|ACSM2A_uc002dhg.3_Missense_Mutation_p.Y315S|ACSM2A_uc010vay.1_Missense_Mutation_p.Y236S|ACSM2A_uc002dhh.3_5'Flank	NM_001010845	NP_001010845	Q08AH3	ACS2A_HUMAN	acyl-CoA synthetase medium-chain family member	315					fatty acid metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|metal ion binding			skin(2)|breast(1)	3						CCCATTGTTTACCGGATGTTG	0.507			NA											8	51					0	0	0.004482	0	0
OTOA	146183	broad.mit.edu	37	16	21698923	21698923	+	Missense_Mutation	SNP	A	A	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr16:21698923A>T	uc002djh.2	+	7	590	c.589A>T	c.(589-591)ACA>TCA	p.T197S	uc002diq.3_Intron|OTOA_uc010vbj.1_Missense_Mutation_p.T118S	NM_144672	NP_653273	Q7RTW8	OTOAN_HUMAN	otoancorin isoform 1	197					sensory perception of sound	anchored to membrane|apical plasma membrane|proteinaceous extracellular matrix				ovary(1)|central_nervous_system(1)|skin(1)	3				GBM - Glioblastoma multiforme(48;0.0414)		GCCAGACATCACAGAGCGGCT	0.488			NA											11	46					0	0	0.010729	0	0
PRKCB	5579	broad.mit.edu	37	16	23848711	23848711	+	Missense_Mutation	SNP	G	G	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr16:23848711G>T	uc002dmd.2	+	2	386	c.189G>T	c.(187-189)CAG>CAT	p.Q63H	PRKCB_uc002dme.2_Missense_Mutation_p.Q63H	NM_212535	NP_997700	P05771	KPCB_HUMAN	protein kinase C, beta isoform 1	63	Phorbol-ester/DAG-type 1.				apoptosis|B cell activation|B cell receptor signaling pathway|intracellular signal transduction|lipoprotein transport|platelet activation|positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|synaptic transmission|transcription, DNA-dependent	cytosol|nucleus|plasma membrane	androgen receptor binding|ATP binding|chromatin binding|histone binding|histone kinase activity (H3-T6 specific)|ligand-dependent nuclear receptor transcription coactivator activity|protein kinase C activity|protein kinase C binding|zinc ion binding			ovary(3)|central_nervous_system(3)|lung(2)|large_intestine(1)	9					Vitamin E(DB00163)	TCGGGAAGCAGGGATTCCAGT	0.547			NA											41	185					1.32136e-16	1.75536e-16	0.00874	1	0
IL4R	3566	broad.mit.edu	37	16	27375021	27375021	+	Missense_Mutation	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr16:27375021C>T	uc002don.2	+	11	2590	c.2348C>T	c.(2347-2349)TCG>TTG	p.S783L	IL4R_uc002dop.3_Missense_Mutation_p.S768L|IL4R_uc010bxy.2_Missense_Mutation_p.S783L|IL4R_uc002doo.2_Missense_Mutation_p.S623L	NM_000418	NP_000409	P24394	IL4RA_HUMAN	interleukin 4 receptor alpha chain isoform a	783	Cytoplasmic (Potential).				immune response|production of molecular mediator involved in inflammatory response	integral to plasma membrane	identical protein binding|interleukin-4 receptor activity|receptor signaling protein activity			ovary(1)|skin(1)	2						CTGGCACCCTCGGGCATCTCA	0.612			NA											14	75					0	0	0.001855	0	0
MAZ	4150	broad.mit.edu	37	16	29819948	29819948	+	Missense_Mutation	SNP	G	G	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr16:29819948G>A	uc002dty.2	+	4	1333	c.1165G>A	c.(1165-1167)GAG>AAG	p.E389K	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|MAZ_uc002dtv.1_Intron|MAZ_uc010vdx.1_Missense_Mutation_p.E366K|MAZ_uc002dtw.2_Intron|MAZ_uc002dtx.2_Missense_Mutation_p.E389K|MAZ_uc010bzg.2_Missense_Mutation_p.E84K|MAZ_uc002dtz.1_3'UTR|MAZ_uc002dua.2_5'UTR|MAZ_uc010vdy.1_5'UTR	NM_002383	NP_002374	P56270	MAZ_HUMAN	MYC-associated zinc finger protein isoform 1	389					regulation of transcription, DNA-dependent|termination of RNA polymerase II transcription|transcription initiation from RNA polymerase II promoter	nucleus	DNA binding|protein binding|RNA binding|zinc ion binding			ovary(1)	1						AGTACGACACGAGGAGAAAGT	0.582	Colon(72;875 1167 15364 30899 37091)		NA											3	27					0	0	0.004672	0	0
SRCAP	10847	broad.mit.edu	37	16	30732215	30732216	+	Missense_Mutation	DNP	GG	GG	TT	rs141288104		TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr16:30732215_30732216GG>TT	uc002dze.1	+	20	3554_3555	c.3169_3170GG>TT	c.(3169-3171)GGG>TTG	p.G1057L	SRCAP_uc002dzf.2_RNA|SRCAP_uc002dzg.1_Missense_Mutation_p.G914L|SRCAP_uc010bzz.1_Missense_Mutation_p.G627L	NM_006662	NP_006653	Q6ZRS2	SRCAP_HUMAN	Snf2-related CBP activator protein	1057	Pro-rich.				interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|nucleus|protein complex	ATP binding|DNA binding|helicase activity|histone acetyltransferase activity|transcription coactivator activity			ovary(3)|skin(1)	4			Colorectal(24;0.198)			CTCACCTGCCGGGCCCCCGCTT	0.639			NA											15	79					0	0	0.004672	0	0
ITGAD	3681	broad.mit.edu	37	16	31422674	31422674	+	Missense_Mutation	SNP	C	C	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr16:31422674C>A	uc002ebv.1	+	14	1592	c.1543C>A	c.(1543-1545)CAC>AAC	p.H515N	ITGAD_uc010cap.1_Missense_Mutation_p.H516N	NM_005353	NP_005344	Q13349	ITAD_HUMAN	integrin, alpha D precursor	515	FG-GAP 6.|Extracellular (Potential).				cell-cell adhesion|cell-matrix adhesion|immune response|integrin-mediated signaling pathway	integrin complex	receptor activity			skin(1)	1						TGAGCAGGGCCACCCCTGGGG	0.622			NA											52	147					6.03219e-31	8.41378e-31	0.01441	1	0
COQ9	57017	broad.mit.edu	37	16	57490421	57490421	+	Silent	SNP	G	G	C			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr16:57490421G>C	uc002elq.2	+	4	400	c.384G>C	c.(382-384)CTG>CTC	p.L128L	COQ9_uc010vhn.1_Silent_p.L128L|COQ9_uc010vho.1_Silent_p.L128L|COQ9_uc010vhp.1_Silent_p.L128L|COQ9_uc002elr.2_Silent_p.L128L|COQ9_uc002els.2_5'Flank	NM_020312	NP_064708	O75208	COQ9_HUMAN	coenzyme Q9 homolog precursor	128					ubiquinone biosynthetic process	mitochondrion				breast(1)	1						TGTAGTCTCTGGGTCTCTCCA	0.512			NA											47	60					0	0	0.01441	0	0
CCDC135	84229	broad.mit.edu	37	16	57761225	57761225	+	Silent	SNP	G	G	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr16:57761225G>A	uc002emi.2	+	15	2189	c.2100G>A	c.(2098-2100)CTG>CTA	p.L700L	CCDC135_uc002emj.2_Silent_p.L700L|CCDC135_uc002emk.2_Silent_p.L635L	NM_032269	NP_115645	Q8IY82	CC135_HUMAN	coiled-coil domain containing 135	700	Potential.					cytoplasm				central_nervous_system(1)	1						TGGAGATTCTGAAGCTTCGAG	0.433			NA											20	91					0	0	0.008871	0	0
CES8	283848	broad.mit.edu	37	16	67034819	67034819	+	Silent	SNP	C	C	G			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr16:67034819C>G	uc002eqv.2	+	4	505	c.462C>G	c.(460-462)GGC>GGG	p.G154G	CES8_uc010vix.1_Silent_p.G154G|CES8_uc002eqw.2_Silent_p.G154G|CES8_uc002eqy.2_Silent_p.G56G|CES8_uc002eqx.2_5'UTR|CES8_uc010viy.1_Silent_p.G56G|CES8_uc010viz.1_Silent_p.G56G	NM_173815	NP_776176	Q5XG92	EST4A_HUMAN	carboxylesterase 8 (putative)	154						extracellular region	carboxylesterase activity				0						CGTACGAGGGCTCTGACTTGG	0.662			NA											12	17					0	0	0.013537	0	0
EXOC3L	283849	broad.mit.edu	37	16	67218614	67218614	+	Missense_Mutation	SNP	G	G	C			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr16:67218614G>C	uc002erx.1	-	13	2246	c.2005C>G	c.(2005-2007)CTG>GTG	p.L669V	KIAA0895L_uc002ert.2_5'Flank|KIAA0895L_uc002eru.2_5'Flank|EXOC3L_uc002erv.1_RNA|EXOC3L_uc002erw.1_Missense_Mutation_p.L320V|EXOC3L_uc002ery.1_Missense_Mutation_p.P601R|EXOC3L_uc010vje.1_Missense_Mutation_p.P596R	NM_178516	NP_848611	Q86VI1	EX3L1_HUMAN	exocyst complex component 3-like	669					exocytosis|peptide hormone secretion	exocyst|stored secretory granule|transport vesicle					0		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0021)|Epithelial(162;0.0073)|all cancers(182;0.0616)		TGTTGCCGCAGGCCAGCCACC	0.716			NA											15	49					0	0	0.00245	0	0
PLA2G15	23659	broad.mit.edu	37	16	68289811	68289811	+	Nonsense_Mutation	SNP	G	G	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr16:68289811G>A	uc002evr.2	+	5	728	c.645G>A	c.(643-645)TGG>TGA	p.W215*	PLA2G15_uc010vld.1_Missense_Mutation_p.E174K|PLA2G15_uc010vle.1_Nonsense_Mutation_p.W121*|PLA2G15_uc010vlf.1_Intron|PLA2G15_uc002evs.2_Nonsense_Mutation_p.W36*	NM_012320	NP_036452	Q8NCC3	PAG15_HUMAN	lysophospholipase 3 (lysosomal phospholipase A2)	215					fatty acid catabolic process	extracellular region|lysosome	lysophospholipase activity|phosphatidylcholine-sterol O-acyltransferase activity|phospholipid binding			ovary(1)	1						CGCAGGCCTGGAAGGACAAGT	0.632			NA											17	35					0	0	0.006122	0	0
SLC7A6	9057	broad.mit.edu	37	16	68309111	68309111	+	Missense_Mutation	SNP	C	C	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr16:68309111C>A	uc002evt.1	+	4	791	c.482C>A	c.(481-483)CCC>CAC	p.P161H	SLC7A6_uc010cfb.1_RNA|SLC7A6_uc002evu.1_Missense_Mutation_p.P161H|SLC7A6_uc002evv.1_RNA|SLC7A6_uc010cfc.1_RNA	NM_001076785	NP_001070253	Q92536	YLAT2_HUMAN	solute carrier family 7 (cationic amino acid	161	Extracellular (Potential).				blood coagulation|cellular amino acid metabolic process|ion transport|leukocyte migration|protein complex assembly	basolateral plasma membrane|integral to plasma membrane	amino acid transmembrane transporter activity|antiporter activity			central_nervous_system(1)	1		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.034)|Epithelial(162;0.0948)		AGCTGTGATCCCCCATACCTG	0.572			NA											18	88					8.00594e-06	8.9558e-06	0.007413	1	0
TMCO7	79613	broad.mit.edu	37	16	68941453	68941453	+	Missense_Mutation	SNP	G	G	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr16:68941453G>T	uc002ewi.3	+	10	1787	c.1775G>T	c.(1774-1776)GGA>GTA	p.G592V		NM_024562	NP_078838	Q9C0B7	TMCO7_HUMAN	transmembrane and coiled-coil domains 7	592						integral to membrane	binding				0		Ovarian(137;0.0568)		OV - Ovarian serous cystadenocarcinoma(108;0.0446)|Epithelial(162;0.198)		GGTTTGGCAGGAGACTTCTTC	0.502			NA											15	21					2.31682e-05	2.54658e-05	0.003163	1	0
CLEC18B	497190	broad.mit.edu	37	16	74443757	74443757	+	Missense_Mutation	SNP	C	C	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr16:74443757C>A	uc002fct.2	-	11	1431	c.1231G>T	c.(1231-1233)GCC>TCC	p.A411S	CLEC18B_uc002fcu.2_Intron	NM_001011880	NP_001011880	Q6UXF7	CL18B_HUMAN	C-type lectin domain family 18, member B	411	C-type lectin.					extracellular region	sugar binding				0						TACCCCATGGCAGCACTCAGC	0.632			NA											5	60					5.18039e-06	5.81293e-06	0.00308	1	0
SLC38A8	146167	broad.mit.edu	37	16	84050323	84050323	+	Missense_Mutation	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr16:84050323C>T	uc002fhg.1	-	8	963	c.963G>A	c.(961-963)ATG>ATA	p.M321I		NM_001080442	NP_001073911	A6NNN8	S38A8_HUMAN	solute carrier family 38, member 8	321					amino acid transport|sodium ion transport	integral to membrane					0						AGAAGTCCTGCATCACTGACC	0.677			NA											17	31					0	0	0.00499	0	0
ITGAE	3682	broad.mit.edu	37	17	3651249	3651249	+	Missense_Mutation	SNP	C	C	G			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr17:3651249C>G	uc002fwo.3	-	17	2221	c.2122G>C	c.(2122-2124)GAA>CAA	p.E708Q		NM_002208	NP_002199	P38570	ITAE_HUMAN	integrin, alpha E precursor	708	Extracellular (Potential).				cell adhesion|integrin-mediated signaling pathway	integrin complex	receptor activity			large_intestine(2)|breast(1)|pancreas(1)	4				UCEC - Uterine corpus endometrioid carcinoma (3;0.0813)		GAGCTGATTTCAAAACATAAA	0.542	NSCLC(182;635 2928 8995 38788)		NA											8	32					0	0	0.00308	0	0
CAMKK1	84254	broad.mit.edu	37	17	3786361	3786361	+	Missense_Mutation	SNP	T	T	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr17:3786361T>A	uc002fwt.2	-	6	717	c.623A>T	c.(622-624)CAC>CTC	p.H208L	CAMKK1_uc002fwu.2_Missense_Mutation_p.H208L|CAMKK1_uc002fwv.2_Missense_Mutation_p.H208L	NM_172206	NP_757343	Q8N5S9	KKCC1_HUMAN	calcium/calmodulin-dependent protein kinase 1	208	Protein kinase.				synaptic transmission	cytosol|nucleus	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			ovary(1)	1				LUAD - Lung adenocarcinoma(2;2.11e-05)|Lung(3;0.0176)		CACATTCACGTGGTCCAGCTT	0.642			NA											26	33					0	0	0.005443	0	0
UBE2G1	7326	broad.mit.edu	37	17	4186205	4186205	+	Silent	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr17:4186205C>T	uc002fxs.2	-	5	796	c.438G>A	c.(436-438)AGG>AGA	p.R146R		NM_003342	NP_003333	P62253	UB2G1_HUMAN	ubiquitin-conjugating enzyme E2G 1	146					protein K48-linked ubiquitination|protein K63-linked ubiquitination|ubiquitin-dependent protein catabolic process		ATP binding|ubiquitin protein ligase binding|ubiquitin-protein ligase activity				0						TTCTATCTTCCCTCCATTCTT	0.323			NA											3	7					0	0	0.004672	0	0
NLRP1	22861	broad.mit.edu	37	17	5463332	5463332	+	Silent	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr17:5463332C>T	uc002gci.2	-	4	1239	c.684G>A	c.(682-684)GAG>GAA	p.E228E	NLRP1_uc002gcg.1_Silent_p.E228E|NLRP1_uc002gck.2_Silent_p.E228E|NLRP1_uc002gcj.2_Silent_p.E228E|NLRP1_uc002gcl.2_Silent_p.E228E|NLRP1_uc002gch.3_Silent_p.E228E|NLRP1_uc010clh.2_Silent_p.E228E	NM_033004	NP_127497	Q9C000	NALP1_HUMAN	NLR family, pyrin domain containing 1 isoform 1	228					defense response to bacterium|induction of apoptosis|neuron apoptosis|positive regulation of interleukin-1 beta secretion|response to muramyl dipeptide	cytoplasm|NALP1 inflammasome complex|nucleus	ATP binding|caspase activator activity|enzyme binding|protein domain specific binding			lung(4)|breast(2)|ovary(1)|central_nervous_system(1)|skin(1)	9		Colorectal(1115;3.48e-05)				GCCTGCCTTTCTCTGATTTCT	0.488			NA											7	28					0	0	0.001984	0	0
SLC13A5	284111	broad.mit.edu	37	17	6606404	6606404	+	Silent	SNP	G	G	T	rs142320179		TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr17:6606404G>T	uc002gdj.2	-	5	689	c.601C>A	c.(601-603)CGG>AGG	p.R201R	SLC13A5_uc010vtf.1_Silent_p.R201R|SLC13A5_uc010clq.2_Silent_p.R158R|SLC13A5_uc002gdk.2_Silent_p.R184R|SLC13A5_uc002gdl.1_Silent_p.R183R	NM_177550	NP_808218	Q86YT5	S13A5_HUMAN	solute carrier family 13, member 5 isoform a	201						integral to membrane	citrate transmembrane transporter activity				0						AACCTCTTCCGCTCTTGGTCT	0.632			NA											39	59					3.78316e-11	4.72732e-11	0.00623	1	0
TP53	7157	broad.mit.edu	37	17	7578550	7578550	+	Missense_Mutation	SNP	G	G	C			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr17:7578550G>C	uc002gim.2	-	5	574	c.380C>G	c.(379-381)TCC>TGC	p.S127C	TP53_uc002gig.1_Missense_Mutation_p.S127C|TP53_uc002gih.2_Missense_Mutation_p.S127C|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_5'UTR|TP53_uc010cng.1_5'UTR|TP53_uc002gii.1_5'UTR|TP53_uc010cnh.1_Missense_Mutation_p.S127C|TP53_uc010cni.1_Missense_Mutation_p.S127C|TP53_uc002gij.2_Missense_Mutation_p.S127C|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.S34C|TP53_uc002gio.2_5'UTR|TP53_uc010vug.1_Missense_Mutation_p.S88C	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	127	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		S -> C (in a sporadic cancer; somatic mutation).|S -> F (in sporadic cancers; somatic mutation).|S -> Y (in sporadic cancers; somatic mutation).|S -> P (in sporadic cancers; somatic mutation).|S -> T (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.S127F(18)|p.S127Y(8)|p.0?(7)|p.Y126_K132delYSPALNK(6)|p.Y126_N131delYSPALN(3)|p.S127P(3)|p.S127T(2)|p.P128fs*42(2)|p.V73fs*9(1)|p.S127fs*36(1)|p.P128fs*18(1)|p.Y126fs*11(1)|p.S127S(1)|p.S127C(1)|p.S127_Q136del10(1)|p.P13fs*18(1)|p.?(1)|p.S127fs*43(1)|p.S127fs*42(1)|p.Y126fs*18(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GAGGGCAGGGGAGTACTGTAG	0.552	Pancreas(47;798 1329 9957 10801)		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumensyndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			19	15					0	0	0.007413	0	0
MYH4	4622	broad.mit.edu	37	17	10361031	10361031	+	Missense_Mutation	SNP	A	A	G			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr17:10361031A>G	uc002gmn.2	-	16	1714	c.1603T>C	c.(1603-1605)TCC>CCC	p.S535P	uc002gml.1_Intron	NM_017533	NP_060003	Q9Y623	MYH4_HUMAN	myosin, heavy polypeptide 4, skeletal muscle	535	Myosin head-like.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(10)|skin(2)|central_nervous_system(1)	13						TCTAGGATGGAGAAGATGCCC	0.403			NA											9	40					0	0	0.004482	0	0
MYH4	4622	broad.mit.edu	37	17	10367852	10367852	+	Nonsense_Mutation	SNP	G	G	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr17:10367852G>T	uc002gmn.2	-	7	696	c.585C>A	c.(583-585)TAC>TAA	p.Y195*	uc002gml.1_Intron	NM_017533	NP_060003	Q9Y623	MYH4_HUMAN	myosin, heavy polypeptide 4, skeletal muscle	195	Myosin head-like.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(10)|skin(2)|central_nervous_system(1)	13						TTGTTGCAAAGTACTGGATGA	0.428			NA											14	23					2.32078e-09	2.8199e-09	0.003163	1	0
MAP2K4	6416	broad.mit.edu	37	17	12028689	12028689	+	Splice_Site	SNP	G	G	C			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr17:12028689G>C	uc002gnj.2	+	8	960	c.891_splice	c.e8+1	p.L297_splice	MAP2K4_uc002gnk.2_Splice_Site_p.L308_splice|MAP2K4_uc010vvi.1_Splice_Site_p.L179_splice|MAP2K4_uc010vvj.1_Splice_Site_p.L169_splice	NM_003010	NP_003001	P45985	MP2K4_HUMAN	mitogen-activated protein kinase kinase 4						cellular response to mechanical stimulus|innate immune response|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol	ATP binding|JUN kinase kinase activity|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity	p.?(1)		large_intestine(14)|breast(12)|lung(8)|ovary(8)|pancreas(8)|stomach(2)|central_nervous_system(1)|biliary_tract(1)|testis(1)|endometrium(1)|urinary_tract(1)|skin(1)	58		all_cancers(5;0.0413)|Breast(5;0.000625)|all_epithelial(5;0.00978)|all_lung(20;0.0449)|Lung NSC(33;0.163)		Epithelial(2;4.12e-09)|all cancers(2;6.86e-07)|BRCA - Breast invasive adenocarcinoma(2;8.74e-07)|Colorectal(4;5.32e-05)|COAD - Colon adenocarcinoma(4;0.0039)|READ - Rectum adenocarcinoma(10;0.0681)		GATCACATTGGTATGTTTATG	0.403			NA	D|Mis|N		pancreatic|breast|colorectal								17	27					0	0	0.004007	0	0
RAI1	10743	broad.mit.edu	37	17	17699745	17699745	+	Silent	SNP	G	G	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr17:17699745G>A	uc002grm.2	+	3	3952	c.3483G>A	c.(3481-3483)CGG>CGA	p.R1161R	RAI1_uc002grn.1_Silent_p.R1161R	NM_030665	NP_109590	Q7Z5J4	RAI1_HUMAN	retinoic acid induced 1	1161	Nuclear localization signal (Potential).					cytoplasm|nucleus	zinc ion binding			central_nervous_system(1)|skin(1)	2				READ - Rectum adenocarcinoma(1115;0.0276)		CCAAGCGGCGGAGGCCCTCTG	0.632			NA											17	58					0	0	0.004007	0	0
EVPLL	645027	broad.mit.edu	37	17	18284947	18284947	+	Silent	SNP	G	G	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr17:18284947G>A	uc002gte.2	+	4	504	c.249G>A	c.(247-249)CAG>CAA	p.Q83Q		NM_001145127	NP_001138599	A8MZ36	EVPLL_HUMAN	envoplakin-like	83	Potential.										0						GGGTGACCCAGGAGTGTGCGG	0.657			NA											14	30					0	0	0.004007	0	0
CCDC144B	284047	broad.mit.edu	37	17	18513562	18513562	+	Missense_Mutation	SNP	C	C	G			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr17:18513562C>G	uc002gub.1	-	3	544	c.459G>C	c.(457-459)CAG>CAC	p.Q153H	CCDC144B_uc002gua.3_RNA|CCDC144B_uc010vyc.1_RNA|CCDC144B_uc002guc.1_Missense_Mutation_p.Q153H	NM_182568	NP_872374			coiled-coil domain containing 144B											ovary(1)|skin(1)	2						TCTTGGATCTCTGACAAGTCT	0.353			NA											8	47					0	0	0.00308	0	0
MAPK7	5598	broad.mit.edu	37	17	19282274	19282274	+	Missense_Mutation	SNP	G	G	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr17:19282274G>T	uc002gvn.2	+	2	447	c.61G>T	c.(61-63)GTG>TTG	p.V21L	B9D1_uc010cqm.1_5'Flank|B9D1_uc002gvl.3_5'Flank|MAPK7_uc002gvo.2_Intron|MAPK7_uc002gvq.2_Missense_Mutation_p.V21L|MAPK7_uc002gvp.2_Missense_Mutation_p.V21L	NM_139033	NP_620602	Q13164	MK07_HUMAN	mitogen-activated protein kinase 7 isoform 1	21	Required for cytoplasmic targeting (By similarity).				cell cycle|cell differentiation|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|MAP kinase activity|protein binding			central_nervous_system(4)|lung(3)|stomach(1)|skin(1)	9	all_cancers(12;2.87e-05)|all_epithelial(12;0.00114)|Hepatocellular(7;0.00345)|Breast(13;0.206)					CCCCGGGCCCGTGAAGGCCGA	0.657			NA											6	10					0.00198382	0.00206488	0.001984	1	0
KCNJ12	3768	broad.mit.edu	37	17	21319507	21319507	+	Silent	SNP	C	C	A	rs143946927	byFrequency	TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr17:21319507C>A	uc002gyv.1	+	3	1558	c.853C>A	c.(853-855)CGG>AGG	p.R285R		NM_021012	NP_066292	Q14500	IRK12_HUMAN	potassium inwardly-rectifying channel, subfamily	285	Cytoplasmic (By similarity).			Missing (in Ref. 1; AAA65122).	blood circulation|muscle contraction|regulation of heart contraction|synaptic transmission	integral to membrane	inward rectifier potassium channel activity|ion channel inhibitor activity|potassium channel regulator activity			ovary(3)|skin(1)	4				Colorectal(15;0.0183)|COAD - Colon adenocarcinoma(3;0.0732)	Dofetilide(DB00204)	CGGCATCAGCCGGCAGGACCT	0.622			NA								Prostate(3;0.18)			10	92					3.86212e-05	4.21639e-05	0.008291	1	0
NOS2	4843	broad.mit.edu	37	17	26094815	26094815	+	Missense_Mutation	SNP	G	G	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr17:26094815G>T	uc002gzu.2	-	18	2347	c.2083C>A	c.(2083-2085)CCC>ACC	p.P695T	NOS2_uc010wab.1_Missense_Mutation_p.P660T	NM_000625	NP_000616	P35228	NOS2_HUMAN	nitric oxide synthase 2A	695					arginine catabolic process|defense response to Gram-negative bacterium|innate immune response in mucosa|nitric oxide biosynthetic process|peptidyl-cysteine S-nitrosylation|platelet activation|positive regulation of killing of cells of other organism|positive regulation of leukocyte mediated cytotoxicity|regulation of cellular respiration|regulation of insulin secretion|superoxide metabolic process	cytosol|nucleus	arginine binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|protein homodimerization activity|tetrahydrobiopterin binding			skin(2)|ovary(1)|breast(1)	4					Dexamethasone(DB01234)|Hydrocortisone(DB00741)|L-Arginine(DB00125)|L-Citrulline(DB00155)	TAGAGCTTGGGGATCTGAATG	0.567			NA											10	32					1.33987e-11	1.68295e-11	0.008291	1	0
SPAG5	10615	broad.mit.edu	37	17	26919437	26919437	+	Missense_Mutation	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr17:26919437C>T	uc002hbq.2	-	3	917	c.825G>A	c.(823-825)ATG>ATA	p.M275I	SGK494_uc010waq.1_Intron	NM_006461	NP_006452	Q96R06	SPAG5_HUMAN	sperm associated antigen 5	275					cell division|mitosis|phosphatidylinositol-mediated signaling|spindle organization	condensed chromosome kinetochore|cytoplasm|spindle pole	protein binding			central_nervous_system(1)	1	Lung NSC(42;0.00431)					CTCTTTCCTCCATAGCTCCAT	0.473			NA											21	50					0	0	0.010504	0	0
SPACA3	124912	broad.mit.edu	37	17	31324729	31324729	+	Splice_Site	SNP	G	G	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr17:31324729G>T	uc002hhs.1	+	5	657	c.582_splice	c.e5-1	p.W194_splice	SPACA3_uc010cte.1_Splice_Site	NM_173847	NP_776246	Q8IXA5	SACA3_HUMAN	sperm acrosome associated 3						cell wall macromolecule catabolic process|defense response to Gram-positive bacterium|monocyte activation|peptidoglycan catabolic process|positive regulation of macrophage activation|positive regulation of phagocytosis|response to virus	acrosomal membrane|extracellular region|integral to membrane|lysosome	bacterial cell surface binding|lysozyme activity|protein binding			ovary(2)	2			BRCA - Breast invasive adenocarcinoma(9;0.193)			TCCATCCTCAGGGAGGCCTGG	0.532			NA											28	50					1.42536e-11	1.78878e-11	0.004656	1	0
MRPL45	84311	broad.mit.edu	37	17	36453205	36453205	+	Missense_Mutation	SNP	G	G	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr17:36453205G>T	uc002hpy.2	+	1	208	c.56G>T	c.(55-57)TGG>TTG	p.W19L		NM_032351	NP_115727	Q9BRJ2	RM45_HUMAN	mitochondrial ribosomal protein L45 precursor	19					intracellular protein transport|translation	mitochondrial inner membrane presequence translocase complex|ribosome	P-P-bond-hydrolysis-driven protein transmembrane transporter activity|structural constituent of ribosome				0	Breast(7;2.97e-12)	Breast(25;0.0101)|Ovarian(249;0.15)				TTGGGCTGGTGGTTTCGGCAG	0.572			NA											15	67					1.99824e-07	2.3286e-07	0.00499	1	0
KRT23	25984	broad.mit.edu	37	17	39092742	39092742	+	Silent	SNP	C	C	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr17:39092742C>A	uc002hvm.1	-	2	703	c.114G>T	c.(112-114)GCG>GCT	p.A38A	KRT23_uc010wfl.1_Intron|KRT23_uc010cxf.1_Intron|KRT23_uc010cxg.2_Silent_p.A38A|KRT23_uc002hvn.1_Silent_p.A38A	NM_015515	NP_056330	Q9C075	K1C23_HUMAN	keratin 23	38	Head.					intermediate filament	structural molecule activity			ovary(1)	1		Breast(137;0.000301)|Ovarian(249;0.15)				GGGCTCCCCCCGCACCGCCAT	0.697			NA											32	64					1.62565e-12	2.06332e-12	0.012213	1	0
JUP	3728	broad.mit.edu	37	17	39681167	39681167	+	Silent	SNP	G	G	C			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr17:39681167G>C	uc010wfs.1	-	6	1085	c.1077C>G	c.(1075-1077)GCC>GCG	p.A359A	KRT19_uc002hxd.3_Silent_p.A196A	NM_021991	NP_068831	P14923	PLAK_HUMAN	junction plakoglobin	Error:Variant_position_missing_in_P14923_after_alignment					adherens junction organization|atrioventricular valve morphogenesis|cell migration|cell morphogenesis|cellular response to indole-3-methanol|cytoskeletal anchoring at plasma membrane|detection of mechanical stimulus|ectoderm development|endothelial cell-cell adhesion|gastrulation|morphogenesis of embryonic epithelium|negative regulation of heart induction by canonical Wnt receptor signaling pathway|negative regulation of Wnt receptor signaling pathway involved in heart development|nervous system development|oocyte development|positive regulation of protein import into nucleus|positive regulation of sequence-specific DNA binding transcription factor activity|skin development	actin cytoskeleton|Axin-APC-beta-catenin-GSK3B complex|basolateral plasma membrane|catenin complex|desmosome|fascia adherens|gamma-catenin-TCF7L2 complex|internal side of plasma membrane|nucleus|protein-DNA complex|Z disc|zonula adherens	alpha-catenin binding|cadherin binding|protein homodimerization activity|protein kinase binding|protein phosphatase binding|RPTP-like protein binding|specific RNA polymerase II transcription factor activity|transcription coactivator activity			ovary(2)|lung(2)|breast(1)	5		Breast(137;0.000162)	BRCA - Breast invasive adenocarcinoma(4;0.233)	BRCA - Breast invasive adenocarcinoma(366;0.15)		GGTCGGTCCTGGCCAGGGTCA	0.572	Colon(16;42 520 6044 17852 28530)		NA											20	133					0	0	0.008871	0	0
TTC25	83538	broad.mit.edu	37	17	40095333	40095333	+	Missense_Mutation	SNP	G	G	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr17:40095333G>T	uc002hyj.3	+	7	1055	c.966G>T	c.(964-966)TTG>TTT	p.L322F	TTC25_uc010cxt.2_RNA|TTC25_uc010cxs.1_Intron	NM_031421	NP_113609	Q96NG3	TTC25_HUMAN	tetratricopeptide repeat domain 25	322	TPR 5.					cytoplasm	protein binding			ovary(1)	1		all_cancers(22;8.16e-06)|Breast(137;0.000143)|all_epithelial(22;0.000236)				TTGGAAACTTGTATAGCTGCA	0.512			NA											9	27					1.12685e-05	1.25378e-05	0.004482	1	0
RAB5C	5878	broad.mit.edu	37	17	40280324	40280324	+	Silent	SNP	C	C	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr17:40280324C>A	uc002hyz.2	-	5	713	c.396G>T	c.(394-396)GCG>GCT	p.A132A	RAB5C_uc002hza.2_Silent_p.A132A|RAB5C_uc010cxx.2_Silent_p.A165A|RAB5C_uc010cxy.2_Silent_p.A44A	NM_201434	NP_958842	P51148	RAB5C_HUMAN	RAB5C, member RAS oncogene family isoform a	132					protein transport|small GTPase mediated signal transduction	early endosome membrane|melanosome|plasma membrane	GTP binding|GTPase activity|protein binding			large_intestine(1)|skin(1)	2		all_cancers(22;1.24e-06)|all_epithelial(22;4.33e-05)|Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.128)		CCTTGTTACCCGCGAGTGCAA	0.587			NA											16	64					6.31663e-08	7.4567e-08	0.003163	1	0
GHDC	84514	broad.mit.edu	37	17	40344578	40344578	+	Silent	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr17:40344578C>T	uc002hzd.2	-	4	1054	c.570G>A	c.(568-570)CTG>CTA	p.L190L	GHDC_uc002hzg.1_Silent_p.L190L|GHDC_uc010wgg.1_Silent_p.L151L|GHDC_uc002hze.3_Silent_p.L190L|GHDC_uc002hzf.3_Silent_p.L190L|GHDC_uc010cxz.2_RNA	NM_032484	NP_115873	Q8N2G8	GHDC_HUMAN	LGP1 homolog isoform 1	190						endoplasmic reticulum|nuclear envelope					0		all_cancers(22;0.000229)|Breast(137;0.00104)|all_epithelial(22;0.00304)		BRCA - Breast invasive adenocarcinoma(366;0.124)		CTGGGGACCTCAGTGCGTCCA	0.652			NA											32	105					0	0	0.010818	0	0
NAGLU	4669	broad.mit.edu	37	17	40695718	40695718	+	Missense_Mutation	SNP	G	G	T	rs104894598		TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr17:40695718G>T	uc002hzv.2	+	6	2034	c.1694G>T	c.(1693-1695)CGG>CTG	p.R565L		NM_000263	NP_000254	P54802	ANAG_HUMAN	alpha-N-acetylglucosaminidase precursor	565			R -> Q (in MPS3B).|R -> W (in MPS3B; accounts for approximately 6% of the mutant alleles in Australasian patients with MPS3B).|R -> P (in MPS3B; does not yield active enzyme).			lysosome	alpha-N-acetylglucosaminidase activity				0		all_cancers(22;1.58e-05)|Breast(137;0.000153)|all_epithelial(22;0.000344)		BRCA - Breast invasive adenocarcinoma(366;0.13)	N-Acetyl-D-glucosamine(DB00141)	GACCTCACTCGGCAGGCAGTG	0.632			NA											3	41					6.4e-05	6.95722e-05	0.004672	1	0
SLC4A1	6521	broad.mit.edu	37	17	42335826	42335826	+	Missense_Mutation	SNP	G	G	C			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr17:42335826G>C	uc002igf.3	-	10	1191	c.1042C>G	c.(1042-1044)CAG>GAG	p.Q348E	SLC4A1_uc002igg.3_Missense_Mutation_p.Q348E	NM_000342	NP_000333	P02730	B3AT_HUMAN	solute carrier family 4, anion exchanger, member	348	Cytoplasmic.				bicarbonate transport|cellular ion homeostasis	basolateral plasma membrane|cortical cytoskeleton|integral to plasma membrane|Z disc	ankyrin binding|chloride transmembrane transporter activity|inorganic anion exchanger activity|protein anchor|protein homodimerization activity			ovary(1)|central_nervous_system(1)|skin(1)	3		Breast(137;0.014)|Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.115)		GGGCTGGACTGATAGCGCCTT	0.637			NA											24	139					0	0	0.00333	0	0
SLC4A1	6521	broad.mit.edu	37	17	42336924	42336924	+	Missense_Mutation	SNP	G	G	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr17:42336924G>A	uc002igf.3	-	8	784	c.635C>T	c.(634-636)TCA>TTA	p.S212L	SLC4A1_uc002igg.3_Missense_Mutation_p.S212L	NM_000342	NP_000333	P02730	B3AT_HUMAN	solute carrier family 4, anion exchanger, member	212	Cytoplasmic.				bicarbonate transport|cellular ion homeostasis	basolateral plasma membrane|cortical cytoskeleton|integral to plasma membrane|Z disc	ankyrin binding|chloride transmembrane transporter activity|inorganic anion exchanger activity|protein anchor|protein homodimerization activity			ovary(1)|central_nervous_system(1)|skin(1)	3		Breast(137;0.014)|Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.115)		TCCAGATGGTGAGTGCCCTTC	0.602			NA											12	63					0	0	0.013537	0	0
GPATCH8	23131	broad.mit.edu	37	17	42478467	42478467	+	Silent	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr17:42478467C>T	uc002igw.1	-	8	1042	c.978G>A	c.(976-978)GGG>GGA	p.G326G	GPATCH8_uc002igv.1_Silent_p.G248G|GPATCH8_uc010wiz.1_Silent_p.G248G	NM_001002909	NP_001002909	Q9UKJ3	GPTC8_HUMAN	G patch domain containing 8	326						intracellular	nucleic acid binding|zinc ion binding			ovary(2)|kidney(1)|skin(1)	4		Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.206)		CTTCAGAGGTCCCTTCCTCCG	0.448			NA									OREG0024461	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	37	145					0	0	0.003755	0	0
KIF18B	146909	broad.mit.edu	37	17	43012664	43012664	+	Missense_Mutation	SNP	T	T	C			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr17:43012664T>C	uc010wji.1	-	3	535	c.434A>G	c.(433-435)CAG>CGG	p.Q145R	KIF18B_uc002iht.2_Missense_Mutation_p.Q145R|KIF18B_uc010wjh.1_Missense_Mutation_p.Q145R	NM_001080443	NP_001073912			kinesin family member 18B											ovary(2)	2		Prostate(33;0.155)				GTGCTTCTCCTGCTGGCGGGC	0.657			NA											3	36					0	0	0.004672	0	0
ACBD4	79777	broad.mit.edu	37	17	43213514	43213514	+	Missense_Mutation	SNP	G	G	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr17:43213514G>T	uc002iid.2	+	2	347	c.3G>T	c.(1-3)ATG>ATT	p.M1I	ACBD4_uc010wjj.1_Missense_Mutation_p.M1I|ACBD4_uc002iie.2_Missense_Mutation_p.M1I|ACBD4_uc002iif.2_Missense_Mutation_p.M1I|ACBD4_uc002iic.2_Missense_Mutation_p.M1I|ACBD4_uc010dae.2_5'UTR	NM_001135707	NP_001129179	Q8NC06	ACBD4_HUMAN	acyl-Coenzyme A binding domain containing 4	1							fatty-acyl-CoA binding			ovary(1)|kidney(1)	2						GCAGCAGCATGGGCACCGAGA	0.627			NA											7	30					0.00198382	0.00206488	0.001984	1	0
CRHR1	1394	broad.mit.edu	37	17	43910522	43910522	+	Missense_Mutation	SNP	G	G	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr17:43910522G>T	uc010dap.2	+	10	1141	c.876G>T	c.(874-876)AGG>AGT	p.R292S	CRHR1_uc010wjx.1_Missense_Mutation_p.R88S|CRHR1_uc002ijp.2_Missense_Mutation_p.R162S|CRHR1_uc002ijm.2_Missense_Mutation_p.R263S|CRHR1_uc002ijn.2_Missense_Mutation_p.R223S|CRHR1_uc010dar.2_Missense_Mutation_p.R263S|CRHR1_uc010dao.2_Missense_Mutation_p.R162S|CRHR1_uc010daq.2_Missense_Mutation_p.R88S	NM_001145146	NP_001138618	P34998	CRFR1_HUMAN	corticotropin releasing hormone receptor 1	292	Extracellular (Potential).				female pregnancy|immune response|parturition	integral to plasma membrane	corticotrophin-releasing factor receptor activity|protein binding			lung(3)	3	Colorectal(2;0.0416)			BRCA - Breast invasive adenocarcinoma(366;0.161)		TTGGCAAAAGGCCTGGGGTGT	0.552	Ovarian(110;57 1568 10207 38216 49865)		NA											12	144					1.36491e-13	1.75696e-13	0.001855	1	0
C17orf57	124989	broad.mit.edu	37	17	45447856	45447856	+	Missense_Mutation	SNP	G	G	C			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr17:45447856G>C	uc002iln.2	+	11	1270	c.859G>C	c.(859-861)GAA>CAA	p.E287Q	C17orf57_uc002ilm.2_Missense_Mutation_p.E191Q|C17orf57_uc002ill.1_Missense_Mutation_p.E43Q|C17orf57_uc010daz.1_Missense_Mutation_p.E239Q	NM_152347	NP_689560	Q8IY85	CQ057_HUMAN	hypothetical protein LOC124989	287							calcium ion binding			breast(1)|central_nervous_system(1)|skin(1)	3						TGAGCTACAGGAACAGTATGA	0.274			NA											3	22					0	0	0.004672	0	0
TBX21	30009	broad.mit.edu	37	17	45822468	45822468	+	Missense_Mutation	SNP	C	C	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr17:45822468C>A	uc002ilv.1	+	6	1555	c.1344C>A	c.(1342-1344)TTC>TTA	p.F448L		NM_013351	NP_037483	Q9UL17	TBX21_HUMAN	T-box 21	448					lymphocyte migration|multicellular organismal development|positive regulation of transcription, DNA-dependent|response to virus	nucleus	sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding				0						CCAGCTGGTTCCGCCCTATGC	0.677			NA											17	36					1.99824e-07	2.3286e-07	0.00499	1	0
PNPO	55163	broad.mit.edu	37	17	46019090	46019090	+	Missense_Mutation	SNP	G	G	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr17:46019090G>A	uc002imo.2	+	1	202	c.49G>A	c.(49-51)GAG>AAG	p.E17K	PNPO_uc010wkz.1_Missense_Mutation_p.E17K|PNPO_uc010wla.1_5'UTR|PNPO_uc010wlb.1_Missense_Mutation_p.E17K	NM_018129	NP_060599	Q9NVS9	PNPO_HUMAN	pyridoxine 5'-phosphate oxidase	17					pyridoxine biosynthetic process	cytosol	FMN binding|pyridoxamine-phosphate oxidase activity				0					Pyridoxal Phosphate(DB00114)	GCGACCTGCCGAGTGGCCAGG	0.706			NA											3	3					0	0	0.004672	0	0
CACNA1G	8913	broad.mit.edu	37	17	48655845	48655845	+	Missense_Mutation	SNP	G	G	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr17:48655845G>T	uc002irk.1	+	9	2593	c.2221G>T	c.(2221-2223)GAC>TAC	p.D741Y	CACNA1G_uc002iri.1_Missense_Mutation_p.D741Y|CACNA1G_uc002irj.1_Missense_Mutation_p.D741Y|CACNA1G_uc002irl.1_Missense_Mutation_p.D741Y|CACNA1G_uc002irm.1_Missense_Mutation_p.D741Y|CACNA1G_uc002irn.1_Missense_Mutation_p.D741Y|CACNA1G_uc002iro.1_Missense_Mutation_p.D741Y|CACNA1G_uc002irp.1_Missense_Mutation_p.D741Y|CACNA1G_uc002irq.1_Missense_Mutation_p.D741Y|CACNA1G_uc002irr.1_Missense_Mutation_p.D741Y|CACNA1G_uc002irs.1_Missense_Mutation_p.D741Y|CACNA1G_uc002irt.1_Missense_Mutation_p.D741Y|CACNA1G_uc002irv.1_Missense_Mutation_p.D741Y|CACNA1G_uc002irw.1_Missense_Mutation_p.D741Y|CACNA1G_uc002iru.1_Missense_Mutation_p.D741Y|CACNA1G_uc002irx.1_Missense_Mutation_p.D654Y|CACNA1G_uc002iry.1_Missense_Mutation_p.D654Y|CACNA1G_uc002irz.1_Missense_Mutation_p.D654Y|CACNA1G_uc002isa.1_Missense_Mutation_p.D654Y|CACNA1G_uc002isb.1_Missense_Mutation_p.D654Y|CACNA1G_uc002isc.1_Missense_Mutation_p.D654Y|CACNA1G_uc002isd.1_Missense_Mutation_p.D654Y|CACNA1G_uc002ise.1_Missense_Mutation_p.D654Y|CACNA1G_uc002isf.1_Missense_Mutation_p.D654Y|CACNA1G_uc002isg.1_Missense_Mutation_p.D654Y|CACNA1G_uc002ish.1_Missense_Mutation_p.D654Y|CACNA1G_uc002isi.1_Missense_Mutation_p.D654Y	NM_018896	NP_061496	O43497	CAC1G_HUMAN	voltage-dependent calcium channel alpha 1G	741	Cytoplasmic (Potential).|II.				axon guidance	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(1)	1	Breast(11;6.7e-17)		BRCA - Breast invasive adenocarcinoma(22;7.52e-09)		Ethosuximide(DB00593)|Flunarizine(DB04841)|Levetiracetam(DB01202)|Mibefradil(DB01388)|Pimozide(DB01100)|Trimethadione(DB00347)|Verapamil(DB00661)|Zonisamide(DB00909)	AAAGATTGTGGACAGCAAGTA	0.597			NA											12	73					3.07112e-06	3.46216e-06	0.010729	1	0
ABCC3	8714	broad.mit.edu	37	17	48761448	48761448	+	Missense_Mutation	SNP	C	C	G			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr17:48761448C>G	uc002isl.2	+	28	4173	c.4093C>G	c.(4093-4095)CAG>GAG	p.Q1365E	ABCC3_uc002isn.2_Missense_Mutation_p.Q119E	NM_003786	NP_003777	O15438	MRP3_HUMAN	ATP-binding cassette, sub-family C, member 3	1365	Cytoplasmic (By similarity).|ABC transporter 2.				bile acid metabolic process	integral to plasma membrane|membrane fraction	ATP binding|bile acid-exporting ATPase activity|organic anion transmembrane transporter activity			skin(3)|central_nervous_system(1)	4			BRCA - Breast invasive adenocarcinoma(22;3.05e-09)		Glibenclamide(DB01016)	CCTGCGCTCTCAGCTGACCAT	0.602			NA											13	34					0	0	0.013537	0	0
VEZF1	7716	broad.mit.edu	37	17	56058018	56058018	+	Missense_Mutation	SNP	G	G	C			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr17:56058018G>C	uc002ivf.1	-	4	1065	c.922C>G	c.(922-924)CAT>GAT	p.H308D	VEZF1_uc010dcn.1_Missense_Mutation_p.H158D	NM_007146	NP_009077	Q14119	VEZF1_HUMAN	zinc finger protein 161	308	C2H2-type 6.				cellular defense response|regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleus	DNA binding|zinc ion binding			ovary(1)|breast(1)	2						CTCTGCCCATGAGTCTTTAAG	0.443			NA											8	56					0	0	0.006214	0	0
TRIM37	4591	broad.mit.edu	37	17	57126552	57126552	+	Missense_Mutation	SNP	T	T	C	rs77807605		TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr17:57126552T>C	uc002iwy.3	-	15	1961	c.1517A>G	c.(1516-1518)AAT>AGT	p.N506S	TRIM37_uc002iwz.3_Missense_Mutation_p.N506S|TRIM37_uc002ixa.3_Missense_Mutation_p.N384S|TRIM37_uc010woc.1_Missense_Mutation_p.N472S	NM_001005207	NP_001005207	O94972	TRI37_HUMAN	tripartite motif-containing 37 protein	506						perinuclear region of cytoplasm|peroxisome	ligase activity|protein binding|zinc ion binding			lung(2)|pancreas(2)|ovary(1)|skin(1)|breast(1)	7	Medulloblastoma(34;0.0922)|all_neural(34;0.101)					ATAATCTTCATTCTGAATCTT	0.363			NA							Mulibrey_Nanism				7	31					0	0	0.00308	0	0
YPEL2	388403	broad.mit.edu	37	17	57430790	57430790	+	Missense_Mutation	SNP	C	C	G			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr17:57430790C>G	uc002ixm.1	+	2	348	c.20C>G	c.(19-21)TCG>TGG	p.S7W	YPEL2_uc002ixl.1_Missense_Mutation_p.S7W	NM_001005404	NP_001005404	Q96QA6	YPEL2_HUMAN	yippee-like 2	7						nucleolus					0	all_neural(34;0.0837)|Medulloblastoma(34;0.0922)					ATGACAAGATCGAAGACTTTC	0.547	Melanoma(86;1113 1364 8518 42220 42625)		NA											12	68					0	0	0.010729	0	0
TUBD1	51174	broad.mit.edu	37	17	57958297	57958297	+	Silent	SNP	T	T	G	rs142691296		TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr17:57958297T>G	uc002ixw.1	-	4	773	c.495A>C	c.(493-495)TCA>TCC	p.S165S	TUBD1_uc010ddf.1_Silent_p.S165S|TUBD1_uc010ddg.1_Silent_p.S130S|TUBD1_uc010ddh.1_Silent_p.S46S|TUBD1_uc010wok.1_Silent_p.S165S|TUBD1_uc002ixx.1_Silent_p.S165S|TUBD1_uc010wol.1_Intron|TUBD1_uc010ddi.1_Intron	NM_016261	NP_057345	Q9UJT1	TBD_HUMAN	delta-tubulin	165					cell differentiation|microtubule-based movement|multicellular organismal development|protein polymerization|spermatogenesis	centriole|microtubule|nucleus	GTP binding|GTPase activity|structural molecule activity			ovary(1)	1	all_cancers(5;3.18e-13)|Breast(5;2.91e-25)|all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		Epithelial(12;9.34e-13)|all cancers(12;1.91e-11)			TCATTTTCAATGAGTTTGAGT	0.343			NA											58	106					0	0	0.01441	0	0
BCAS3	54828	broad.mit.edu	37	17	58786579	58786579	+	Splice_Site	SNP	G	G	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr17:58786579G>A	uc002iyv.3	+	5	324	c.215_splice	c.e5-1	p.D72_splice	BCAS3_uc010wow.1_Intron|BCAS3_uc002iyu.3_Splice_Site_p.D72_splice|BCAS3_uc002iyw.3_Splice_Site_p.D68_splice	NM_001099432	NP_001092902	Q9H6U6	BCAS3_HUMAN	breast carcinoma amplified sequence 3 isoform 1							nucleus				ovary(2)|central_nervous_system(2)|skin(1)	5			BRCA - Breast invasive adenocarcinoma(1;3.11e-12)|Epithelial(12;8.2e-07)|all cancers(12;5.33e-06)			TTCTAATGCAGATACATCAAG	0.328			NA											14	32					0	0	0.003163	0	0
SMURF2	64750	broad.mit.edu	37	17	62558992	62558992	+	Missense_Mutation	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr17:62558992C>T	uc002jep.1	-	11	1497	c.1109G>A	c.(1108-1110)CGA>CAA	p.R370Q	SMURF2_uc002jeq.1_Missense_Mutation_p.R129Q|SMURF2_uc002jer.1_Missense_Mutation_p.R129Q	NM_022739	NP_073576	Q9HAU4	SMUF2_HUMAN	SMAD specific E3 ubiquitin protein ligase 2	370					BMP signaling pathway|negative regulation of transcription, DNA-dependent|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|regulation of transforming growth factor beta receptor signaling pathway|transforming growth factor beta receptor signaling pathway|ubiquitin-dependent SMAD protein catabolic process	cytosol|membrane raft|nucleus|plasma membrane|ubiquitin ligase complex	identical protein binding|SMAD binding|ubiquitin-protein ligase activity			skin(3)|lung(1)	4	Breast(5;1.32e-14)		BRCA - Breast invasive adenocarcinoma(8;9.88e-12)			AACCAGGTCTCGCTTGTACCT	0.463			NA											7	37					0	0	0.00308	0	0
RGS9	8787	broad.mit.edu	37	17	63189700	63189700	+	Silent	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr17:63189700C>T	uc002jfe.2	+	12	896	c.786C>T	c.(784-786)GCC>GCT	p.A262A	RGS9_uc010dem.2_Silent_p.A259A|RGS9_uc002jfd.2_Silent_p.A259A|RGS9_uc002jff.2_RNA|RGS9_uc002jfg.2_Silent_p.A33A	NM_003835	NP_003826	O75916	RGS9_HUMAN	regulator of G-protein signaling 9 isoform 1	262	G protein gamma.				intracellular signal transduction|negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway|visual perception	cytoplasm|heterotrimeric G-protein complex	GTPase activator activity|signal transducer activity			ovary(2)|skin(2)	4						CCAACGATGCCATCATGTCAG	0.423			NA											6	25					0	0	0.00308	0	0
ABCA9	10350	broad.mit.edu	37	17	67012515	67012515	+	Missense_Mutation	SNP	A	A	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr17:67012515A>T	uc002jhu.2	-	22	3061	c.2918T>A	c.(2917-2919)ATA>AAA	p.I973K	ABCA9_uc010dez.2_Missense_Mutation_p.I973K	NM_080283	NP_525022	Q8IUA7	ABCA9_HUMAN	ATP-binding cassette, sub-family A, member 9	973					transport	integral to membrane	ATP binding|ATPase activity			ovary(4)|upper_aerodigestive_tract(1)|central_nervous_system(1)	6	Breast(10;1.47e-12)					ATTACATGCTATTGAAAATCT	0.343			NA											4	34					0	0	0.009096	0	0
SDK2	54549	broad.mit.edu	37	17	71427710	71427711	+	Missense_Mutation	DNP	CC	CC	AT			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr17:71427710_71427711CC>AT	uc010dfm.2	-	11	1410_1411	c.1410_1411GG>AT	c.(1408-1413)GCGGGG>GCATGG	p.G471W	SDK2_uc010dfn.2_Missense_Mutation_p.G150W	NM_001144952	NP_001138424	Q58EX2	SDK2_HUMAN	sidekick 2	471	Ig-like C2-type 5.|Extracellular (Potential).				cell adhesion	integral to membrane				ovary(2)	2						GTGTAGGTCCCCGCATCGGAGA	0.629			NA											63	190					0	0	0.004672	0	0
TTYH2	94015	broad.mit.edu	37	17	72233616	72233616	+	Nonsense_Mutation	SNP	A	A	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr17:72233616A>T	uc002jkc.2	+	4	629	c.598A>T	c.(598-600)AAG>TAG	p.K200*	TTYH2_uc010wqw.1_Nonsense_Mutation_p.K179*	NM_032646	NP_116035	Q9BSA4	TTYH2_HUMAN	tweety 2 isoform 1	200	Extracellular (Potential).					chloride channel complex|plasma membrane	chloride channel activity|protein binding			ovary(3)|large_intestine(1)	4						GGAGCTGACCAAGCTATCCGA	0.572			NA											11	59					0	0	0.013537	0	0
CD300A	11314	broad.mit.edu	37	17	72469792	72469792	+	Missense_Mutation	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr17:72469792C>T	uc002jkv.2	+	2	479	c.158C>T	c.(157-159)CCA>CTA	p.P53L	CD300A_uc002jkw.2_Intron|CD300A_uc010dfr.2_Intron|CD300A_uc010dfs.2_Intron	NM_007261	NP_009192	Q9UGN4	CLM8_HUMAN	leukocyte membrane antigen	53	Extracellular (Potential).|Ig-like V-type.				cell adhesion	integral to membrane|plasma membrane	receptor activity			ovary(1)|skin(1)	2						TGCAGACCACCACAGATTTTC	0.547			NA											18	96					0	0	0.006122	0	0
FADS6	283985	broad.mit.edu	37	17	72875562	72875562	+	Missense_Mutation	SNP	G	G	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr17:72875562G>A	uc002jmd.1	-	5	890	c.878C>T	c.(877-879)CCC>CTC	p.P293L	FADS6_uc010wrn.1_Missense_Mutation_p.P147L	NM_178128	NP_835229	Q8N9I5	FADS6_HUMAN	fatty acid desaturase domain family, member 6	299					fatty acid biosynthetic process	integral to membrane	oxidoreductase activity				0	all_lung(278;0.172)|Lung NSC(278;0.207)					AGAGAGCCTGGGGAATAGATG	0.582			NA											10	53					0	0	0.013537	0	0
LLGL2	3993	broad.mit.edu	37	17	73567113	73567113	+	Missense_Mutation	SNP	G	G	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr17:73567113G>T	uc002joh.2	+	17	2262	c.2108G>T	c.(2107-2109)CGC>CTC	p.R703L	LLGL2_uc002joi.2_Missense_Mutation_p.R703L|LLGL2_uc010dgg.1_Missense_Mutation_p.R703L|LLGL2_uc002joj.2_Missense_Mutation_p.R692L|LLGL2_uc010wsd.1_Missense_Mutation_p.R330L	NM_001031803	NP_001026973	Q6P1M3	L2GL2_HUMAN	lethal giant larvae homolog 2 isoform c	703					cell cycle|cell division|exocytosis|regulation of establishment or maintenance of cell polarity	cytoplasm|intracellular membrane-bounded organelle	PDZ domain binding			ovary(2)	2	all_cancers(13;3.15e-09)|all_epithelial(9;5.78e-10)|Breast(9;5.8e-10)|all_lung(278;0.246)		all cancers(21;1.8e-07)|Epithelial(20;1.38e-06)|Lung(188;0.0696)|LUSC - Lung squamous cell carcinoma(166;0.112)			ATCGAGGCTCGCTCGGCAGAG	0.657			NA											57	81					9.53978e-28	1.32553e-27	0.01441	1	0
EXOC7	23265	broad.mit.edu	37	17	74094015	74094015	+	Missense_Mutation	SNP	C	C	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr17:74094015C>A	uc002jqs.2	-	5	597	c.502G>T	c.(502-504)GTG>TTG	p.V168L	EXOC7_uc010dgv.1_Missense_Mutation_p.V115L|EXOC7_uc002jqq.2_Missense_Mutation_p.V168L|EXOC7_uc010wsw.1_Missense_Mutation_p.V168L|EXOC7_uc010wsx.1_Missense_Mutation_p.V168L|EXOC7_uc002jqr.2_Missense_Mutation_p.V168L|EXOC7_uc010wsv.1_Missense_Mutation_p.V127L|EXOC7_uc002jqu.2_Missense_Mutation_p.V168L	NM_001145297	NP_001138769	Q9UPT5	EXOC7_HUMAN	exocyst complex component 7 isoform 4	168					exocytosis|protein transport	centriolar satellite|cytosol|exocyst|plasma membrane	protein binding				0			LUSC - Lung squamous cell carcinoma(166;0.187)			AAGATGAGCACGGGCGAGACG	0.592			NA											25	111					3.28513e-13	4.20265e-13	0.003954	1	0
MFSD11	79157	broad.mit.edu	37	17	74740468	74740468	+	Silent	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr17:74740468C>T	uc002jta.2	+	8	1534	c.561C>T	c.(559-561)TTC>TTT	p.F187F	MFSD11_uc002jtb.2_Silent_p.F187F|MFSD11_uc010dha.2_Silent_p.F135F|MFSD11_uc002jtc.2_Silent_p.F187F|MFSD11_uc002jtd.3_Silent_p.F187F|MFSD11_uc010dhb.2_Silent_p.F135F|MFSD11_uc002jte.2_Silent_p.F187F	NM_024311	NP_077287	O43934	MFS11_HUMAN	major facilitator superfamily domain containing	187	Helical; (Potential).					integral to membrane				ovary(1)	1						CAGTTCTATTCTTTCTCATTC	0.418			NA											11	67					0	0	0.008291	0	0
DNAH17	8632	broad.mit.edu	37	17	76455187	76455187	+	Missense_Mutation	SNP	C	C	G	rs145638188	byFrequency	TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr17:76455187C>G	uc010dhp.1	-	6	979	c.757G>C	c.(757-759)GAG>CAG	p.E253Q	DNAH17_uc002jvs.2_RNA					SubName: Full=DNAH17 variant protein; Flags: Fragment;											ovary(6)|breast(2)|skin(1)	9			BRCA - Breast invasive adenocarcinoma(99;0.00294)|OV - Ovarian serous cystadenocarcinoma(97;0.0656)			CAGTAGACCTCGTAGAAGCGG	0.607			NA											11	221					0	0	0.004007	0	0
Unknown	0	broad.mit.edu	37	17	78265440	78265440	+	Missense_Mutation	SNP	G	G	C			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr17:78265440G>C	uc002jyf.2	+	8	1428	c.1285G>C	c.(1285-1287)GAC>CAC	p.D429H	uc002jyg.1_Missense_Mutation_p.D160H	NM_020954	NP_066005			hypothetical protein LOC57714												NA						CTTGGGTCATGACCGCGTTCT	0.408			NA											23	98					0	0	0.00278	0	0
RNF213	57674	broad.mit.edu	37	17	78357570	78357570	+	Missense_Mutation	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr17:78357570C>T	uc002jyh.1	+	34	8606	c.8383C>T	c.(8383-8385)CCA>TCA	p.P2795S	uc002jyi.1_Intron|RNF213_uc010dhx.1_5'Flank	NM_020914	NP_065965	Q9HCF4	ALO17_HUMAN	ring finger protein 213	Error:Variant_position_missing_in_Q9HCF4_after_alignment										ovary(8)|lung(6)|breast(3)|large_intestine(2)|central_nervous_system(1)|pancreas(1)	21	all_neural(118;0.0538)		BRCA - Breast invasive adenocarcinoma(99;0.0252)|OV - Ovarian serous cystadenocarcinoma(97;0.057)			ATATGGTGACCCAGTGACCTT	0.468			NA											3	48					0	0	0.004672	0	0
SLC38A10	124565	broad.mit.edu	37	17	79234101	79234101	+	Missense_Mutation	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr17:79234101C>T	uc002jzz.1	-	11	1600	c.1225G>A	c.(1225-1227)GCC>ACC	p.A409T	SLC38A10_uc002jzy.1_Missense_Mutation_p.A327T|SLC38A10_uc002kab.2_Missense_Mutation_p.A409T	NM_001037984	NP_001033073	Q9HBR0	S38AA_HUMAN	solute carrier family 38, member 10 isoform a	409					amino acid transport|sodium ion transport	integral to membrane				pancreas(1)|skin(1)	2	all_neural(118;0.0804)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0272)|OV - Ovarian serous cystadenocarcinoma(97;0.117)			CCGCCAGGGGCTTCCTCTGCC	0.657			NA											10	10					0	0	0.008291	0	0
SLC38A10	124565	broad.mit.edu	37	17	79250893	79250893	+	Missense_Mutation	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr17:79250893C>T	uc002jzz.1	-	7	1042	c.667G>A	c.(667-669)GTG>ATG	p.V223M	SLC38A10_uc002jzy.1_Missense_Mutation_p.V141M|SLC38A10_uc002kab.2_Missense_Mutation_p.V223M	NM_001037984	NP_001033073	Q9HBR0	S38AA_HUMAN	solute carrier family 38, member 10 isoform a	223					amino acid transport|sodium ion transport	integral to membrane				pancreas(1)|skin(1)	2	all_neural(118;0.0804)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0272)|OV - Ovarian serous cystadenocarcinoma(97;0.117)			ATGGTTTTCACTGACGGCTCA	0.572			NA											9	50					0	0	0.008291	0	0
LRRC30	339291	broad.mit.edu	37	18	7231811	7231811	+	Silent	SNP	G	G	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr18:7231811G>T	uc010wzk.1	+	1	675	c.675G>T	c.(673-675)CCG>CCT	p.P225P		NM_001105581	NP_001099051	A6NM36	LRC30_HUMAN	leucine rich repeat containing 30	225	LRR 7.									ovary(1)|liver(1)	2						ACTCCTTCCCGAGGTCGCTTT	0.577			NA											16	53					1.62849e-17	2.16933e-17	0.004007	1	0
C18orf1	753	broad.mit.edu	37	18	13387578	13387578	+	Translation_Start_Site	SNP	G	G	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr18:13387578G>T	uc002ksa.2	+	3	525	c.-143G>T	c.(-145--141)CAGGT>CATGT		C18orf1_uc002ksb.2_Translation_Start_Site	NM_181481	NP_852146	O15165	CR001_HUMAN	hypothetical protein LOC753 isoform alpha 1							integral to membrane|plasma membrane				ovary(2)|skin(1)	3				READ - Rectum adenocarcinoma(73;0.0642)		GAGCCGGGCAGGTGGGCCGCG	0.736			NA											5	19					0.00116845	0.00122497	0.001168	1	0
ROCK1	6093	broad.mit.edu	37	18	18550453	18550453	+	Missense_Mutation	SNP	C	C	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr18:18550453C>A	uc002kte.2	-	23	3617	c.2676G>T	c.(2674-2676)TTG>TTT	p.L892F		NM_005406	NP_005397	Q13464	ROCK1_HUMAN	Rho-associated, coiled-coil containing protein	892	Glu-rich.				actin cytoskeleton organization|axon guidance|cellular component disassembly involved in apoptosis|cytokinesis|leukocyte tethering or rolling|membrane to membrane docking|Rho protein signal transduction	centriole|cytosol|Golgi membrane	ATP binding|identical protein binding|metal ion binding|protein serine/threonine kinase activity			lung(2)|breast(2)|central_nervous_system(1)	5	Melanoma(1;0.165)					CTGCTAGATCCAACTGAGTAG	0.378			NA											9	20					0.000442599	0.000469777	0.006214	1	0
MIB1	57534	broad.mit.edu	37	18	19359454	19359454	+	Missense_Mutation	SNP	G	G	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr18:19359454G>A	uc002ktq.2	+	6	716	c.716G>A	c.(715-717)GGC>GAC	p.G239D	MIB1_uc002ktp.2_5'UTR	NM_020774	NP_065825	Q86YT6	MIB1_HUMAN	mindbomb homolog 1	239					Notch signaling pathway	centrosome|nuclear membrane|plasma membrane	ubiquitin-protein ligase activity|zinc ion binding			ovary(4)	4			STAD - Stomach adenocarcinoma(5;0.212)			GAGCAGAATGGCAACAGGAAT	0.408			NA											7	42					0	0	0.001984	0	0
ANKRD29	147463	broad.mit.edu	37	18	21214028	21214028	+	Missense_Mutation	SNP	T	T	C			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr18:21214028T>C	uc002kun.2	-	5	573	c.416A>G	c.(415-417)CAT>CGT	p.H139R	ANKRD29_uc002kuo.2_Missense_Mutation_p.H139R	NM_173505	NP_775776	Q8N6D5	ANR29_HUMAN	ankyrin repeat domain 29	139	ANK 4.									ovary(3)|breast(1)	4	all_cancers(21;5.07e-05)|all_epithelial(16;2.49e-07)|Lung NSC(20;0.00211)|all_lung(20;0.00676)|Colorectal(14;0.0202)|Ovarian(20;0.127)					AAGTTGGTCATGGATGTTTGC	0.493			NA											10	35					0	0	0.010729	0	0
HRH4	59340	broad.mit.edu	37	18	22040786	22040786	+	Nonsense_Mutation	SNP	G	G	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr18:22040786G>T	uc002kvi.2	+	1	194	c.94G>T	c.(94-96)GGA>TGA	p.G32*	HRH4_uc010xbd.1_Nonsense_Mutation_p.G32*|HRH4_uc010dlx.2_Nonsense_Mutation_p.G32*	NM_021624	NP_067637	Q9H3N8	HRH4_HUMAN	histamine H4 receptor isoform 1	32	Helical; Name=1; (Potential).					integral to membrane|plasma membrane	histamine receptor activity			ovary(2)	2	all_cancers(21;0.000545)|all_epithelial(16;6.56e-06)|Lung NSC(20;0.0027)|all_lung(20;0.0085)|Colorectal(14;0.0361)|Ovarian(20;0.0991)				Clozapine(DB00363)	TATAATGCTAGGAAATGCTTT	0.353			NA											27	49					4.7796e-09	5.7785e-09	0.004656	1	0
ZNF521	25925	broad.mit.edu	37	18	22805686	22805686	+	Missense_Mutation	SNP	G	G	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr18:22805686G>T	uc002kvk.2	-	4	2443	c.2196C>A	c.(2194-2196)GAC>GAA	p.D732E	ZNF521_uc010xbe.1_RNA|ZNF521_uc010dly.2_Missense_Mutation_p.D732E|ZNF521_uc002kvl.2_Missense_Mutation_p.D512E	NM_015461	NP_056276	Q96K83	ZN521_HUMAN	zinc finger protein 521	732	C2H2-type 17.				cell differentiation|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein domain specific binding|zinc ion binding			ovary(4)|large_intestine(2)|lung(1)	7	all_cancers(21;0.0025)|all_epithelial(16;3.62e-05)|Ovarian(20;0.0991)					AGACTTTTGAGTCAAAAACTT	0.473			NA	T	PAX5	ALL								4	84					2.56e-06	2.89947e-06	0.009096	1	0
ZNF521	25925	broad.mit.edu	37	18	22807148	22807148	+	Missense_Mutation	SNP	G	G	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr18:22807148G>T	uc002kvk.2	-	4	981	c.734C>A	c.(733-735)ACT>AAT	p.T245N	ZNF521_uc010xbe.1_RNA|ZNF521_uc010dly.2_Missense_Mutation_p.T245N|ZNF521_uc002kvl.2_Missense_Mutation_p.T25N	NM_015461	NP_056276	Q96K83	ZN521_HUMAN	zinc finger protein 521	245					cell differentiation|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein domain specific binding|zinc ion binding			ovary(4)|large_intestine(2)|lung(1)	7	all_cancers(21;0.0025)|all_epithelial(16;3.62e-05)|Ovarian(20;0.0991)					GCACTTCTGAGTGTCCTTCAT	0.532			NA	T	PAX5	ALL								20	38					3.5997e-14	4.67092e-14	0.014323	1	0
KCTD1	284252	broad.mit.edu	37	18	24035815	24035815	+	Silent	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr18:24035815C>T	uc002kvw.2	-	5	1226	c.666G>A	c.(664-666)GGG>GGA	p.G222G	KCTD1_uc010xbj.1_Silent_p.G830G|KCTD1_uc010xbk.1_Silent_p.G222G|KCTD1_uc002kvy.2_3'UTR	NM_001136205	NP_001129677	Q719H9	KCTD1_HUMAN	potassium channel tetramerisation domain	222					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|voltage-gated potassium channel complex	transcription corepressor activity|transcription factor binding|voltage-gated potassium channel activity			ovary(1)	1	all_cancers(21;0.00191)|Lung NSC(5;0.000698)|all_lung(6;0.0019)|Ovarian(20;0.0848)		Epithelial(2;7.8e-06)|OV - Ovarian serous cystadenocarcinoma(3;9.02e-06)|all cancers(3;3.37e-05)			CTACTCCTCCCCCACAGGAGC	0.572			NA											7	72					0	0	0.00308	0	0
CDH2	1000	broad.mit.edu	37	18	25589787	25589787	+	Missense_Mutation	SNP	C	C	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr18:25589787C>A	uc002kwg.2	-	5	1055	c.596G>T	c.(595-597)GGG>GTG	p.G199V	CDH2_uc010xbn.1_Missense_Mutation_p.G168V	NM_001792	NP_001783	P19022	CADH2_HUMAN	cadherin 2, type 1 preproprotein	199	Cadherin 1.|Extracellular (Potential).				adherens junction organization|cell junction assembly|positive regulation of muscle cell differentiation	catenin complex|integral to membrane	alpha-catenin binding|beta-catenin binding|calcium ion binding|gamma-catenin binding			ovary(3)|lung(1)	4						AGCTCCTGGCCCAGTTACACT	0.488			NA											13	48					1.5842e-08	1.8979e-08	0.001855	1	0
DSG4	147409	broad.mit.edu	37	18	28993526	28993526	+	Silent	SNP	C	C	A	rs147705128	by1000genomes	TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr18:28993526C>A	uc002kwq.2	+	16	3226	c.3091C>A	c.(3091-3093)CGA>AGA	p.R1031R	DSG4_uc002kwr.2_Silent_p.R1050R	NM_177986	NP_817123	Q86SJ6	DSG4_HUMAN	desmoglein 4 isoform 2 preproprotein	1031	Cytoplasmic (Potential).				homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			central_nervous_system(5)|ovary(3)	8			OV - Ovarian serous cystadenocarcinoma(10;0.00504)			CAGAGTAACACGATACAGTAA	0.438			NA											23	26					1.55469e-16	2.06157e-16	0.00333	1	0
KLHL14	57565	broad.mit.edu	37	18	30260213	30260213	+	Missense_Mutation	SNP	C	C	G			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr18:30260213C>G	uc002kxm.1	-	7	1895	c.1507G>C	c.(1507-1509)GAT>CAT	p.D503H	KLHL14_uc010dmd.1_Missense_Mutation_p.D52H	NM_020805	NP_065856	Q9P2G3	KLH14_HUMAN	kelch-like 14	503	Kelch 4.					cytosol|endoplasmic reticulum membrane				ovary(1)	1						GTGTTCATATCTTGTTTTCGA	0.378			NA											11	57					0	0	0.010729	0	0
ASXL3	80816	broad.mit.edu	37	18	31326136	31326136	+	Missense_Mutation	SNP	G	G	C			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr18:31326136G>C	uc010dmg.1	+	12	6379	c.6324G>C	c.(6322-6324)ATG>ATC	p.M2108I	ASXL3_uc002kxq.2_Missense_Mutation_p.M1815I	NM_030632	NP_085135	Q9C0F0	ASXL3_HUMAN	additional sex combs like 3	2108					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding			ovary(2)|pancreas(1)	3						AGAATGAAATGAAAGAACAGT	0.383			NA											3	86					0	0	0.004672	0	0
DTNA	1837	broad.mit.edu	37	18	32438301	32438301	+	Nonsense_Mutation	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr18:32438301C>T	uc010dmn.1	+	15	1505	c.1504C>T	c.(1504-1506)CAG>TAG	p.Q502*	DTNA_uc010xbx.1_Nonsense_Mutation_p.Q252*|DTNA_uc002kxv.3_Nonsense_Mutation_p.Q445*|DTNA_uc002kxw.2_Nonsense_Mutation_p.Q445*|DTNA_uc010dmj.2_Nonsense_Mutation_p.Q442*|DTNA_uc002kxz.2_Nonsense_Mutation_p.Q442*|DTNA_uc002kxy.2_Nonsense_Mutation_p.Q442*|DTNA_uc010dml.2_Nonsense_Mutation_p.Q442*|DTNA_uc002kyb.3_Nonsense_Mutation_p.Q499*|DTNA_uc010dmm.2_Nonsense_Mutation_p.Q502*|DTNA_uc010xby.1_Nonsense_Mutation_p.Q192*|DTNA_uc010dmo.2_Nonsense_Mutation_p.Q124*|DTNA_uc002kyd.3_Nonsense_Mutation_p.Q124*|DTNA_uc010xbz.1_Nonsense_Mutation_p.Q211*|DTNA_uc010xca.1_Nonsense_Mutation_p.Q154*|DTNA_uc002kye.2_Nonsense_Mutation_p.Q150*	NM_001390	NP_001381	Q9Y4J8	DTNA_HUMAN	dystrobrevin alpha isoform 1	502	Potential.				neuromuscular synaptic transmission|signal transduction|striated muscle contraction	cell junction|cytoplasm|synapse	calcium ion binding|protein binding|zinc ion binding				0						ACAAGCTTCTCAGCCCACGCC	0.512			NA											11	51					0	0	0.013537	0	0
ELP2	55250	broad.mit.edu	37	18	33734940	33734940	+	Missense_Mutation	SNP	G	G	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr18:33734940G>T	uc002kzk.1	+	12	1263	c.1253G>T	c.(1252-1254)TGG>TTG	p.W418L	ELP2_uc010xcg.1_Missense_Mutation_p.W483L|ELP2_uc002kzl.1_RNA|ELP2_uc002kzm.1_Missense_Mutation_p.W392L|ELP2_uc010xch.1_Missense_Mutation_p.W413L|ELP2_uc002kzn.1_Missense_Mutation_p.W348L|ELP2_uc002kzo.1_Missense_Mutation_p.W348L	NM_018255	NP_060725	Q6IA86	ELP2_HUMAN	elongator protein 2	418	WD 8.				regulation of transcription from RNA polymerase II promoter	Golgi apparatus|transcription elongation factor complex				breast(2)|ovary(1)|skin(1)	4						TTTGCTCCATGGAAGAGAAAA	0.274			NA											15	22					6.31663e-08	7.4567e-08	0.003163	1	0
SYT4	6860	broad.mit.edu	37	18	40851705	40851705	+	Silent	SNP	C	C	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr18:40851705C>A	uc002law.2	-	3	1311	c.942G>T	c.(940-942)CTG>CTT	p.L314L	SYT4_uc010dng.2_RNA|SYT4_uc010xcm.1_Silent_p.L296L|SYT4_uc010dnh.2_Intron	NM_020783	NP_065834	Q9H2B2	SYT4_HUMAN	synaptotagmin IV	314	C2 2.|Cytoplasmic (Potential).					cell junction|integral to membrane|synaptic vesicle membrane	transporter activity			skin(5)	5						CAGATTTAGGCAGATGTCGAG	0.428	NSCLC(85;81 1419 2855 22820 35912)		NA											6	23					8.12818e-05	8.78788e-05	0.001984	1	0
SETBP1	26040	broad.mit.edu	37	18	42530068	42530068	+	Missense_Mutation	SNP	G	G	C			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr18:42530068G>C	uc010dni.2	+	4	1059	c.763G>C	c.(763-765)GAG>CAG	p.E255Q		NM_015559	NP_056374	Q9Y6X0	SETBP_HUMAN	SET binding protein 1 isoform a	255						nucleus	DNA binding			upper_aerodigestive_tract(2)|large_intestine(1)	3				Colorectal(1;0.0622)|COAD - Colon adenocarcinoma(74;0.201)		CCCCGCTCTTGAGCCCGTGGC	0.537			NA							Schinzel-Giedion_syndrome				31	88					0	0	0.008361	0	0
SLC14A2	8170	broad.mit.edu	37	18	43223121	43223121	+	Missense_Mutation	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr18:43223121C>T	uc010dnj.2	+	10	1472	c.1151C>T	c.(1150-1152)GCA>GTA	p.A384V	SLC14A2_uc002lbb.2_Missense_Mutation_p.A384V|SLC14A2_uc002lbe.2_Missense_Mutation_p.A384V	NM_007163	NP_009094	Q15849	UT2_HUMAN	solute carrier family 14 (urea transporter),	384	Helical; (Potential).					apical plasma membrane|integral to membrane|membrane fraction	protein binding|urea transmembrane transporter activity			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)|skin(1)	4						TACATGGAAGCAGCCATCTCC	0.542			NA											9	28					0	0	0.006214	0	0
ATP5A1	498	broad.mit.edu	37	18	43669547	43669547	+	Missense_Mutation	SNP	C	C	G			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr18:43669547C>G	uc002lbr.1	-	5	725	c.635G>C	c.(634-636)GGT>GCT	p.G212A	ATP5A1_uc010dnl.1_Missense_Mutation_p.G162A|ATP5A1_uc002lbs.1_Missense_Mutation_p.G162A|ATP5A1_uc002lbt.1_Missense_Mutation_p.G212A|ATP5A1_uc010xct.1_Missense_Mutation_p.G162A|ATP5A1_uc010dnm.1_RNA	NM_004046	NP_004037	P25705	ATPA_HUMAN	ATP synthase, H+ transporting, mitochondrial F1	212	ATP (By similarity).				ATP hydrolysis coupled proton transport|embryo development|lipid metabolic process|negative regulation of endothelial cell proliferation|respiratory electron transport chain	mitochondrial matrix|plasma membrane	ATP binding|eukaryotic cell surface binding|hydrogen ion transporting ATP synthase activity, rotational mechanism|MHC class I protein binding|proton-transporting ATPase activity, rotational mechanism				0						CTGTCGGTCACCAATAATCAG	0.408			NA											5	34					0	0	0.000602	0	0
TCEB3B	51224	broad.mit.edu	37	18	44560240	44560240	+	Missense_Mutation	SNP	A	A	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr18:44560240A>T	uc002lcr.1	-	1	1749	c.1396T>A	c.(1396-1398)TCA>ACA	p.S466T	KATNAL2_uc010dnq.1_Intron|KATNAL2_uc002lco.2_Intron|KATNAL2_uc002lcp.3_Intron	NM_016427	NP_057511	Q8IYF1	ELOA2_HUMAN	elongin A2	466					regulation of transcription elongation, DNA-dependent|transcription from RNA polymerase II promoter	integral to membrane|nucleus	DNA binding			ovary(2)|large_intestine(1)|pancreas(1)	4						CAGGCCTCTGAGAGGTCCCAG	0.602			NA											21	115					0	0	0.010504	0	0
ST8SIA3	51046	broad.mit.edu	37	18	55024197	55024197	+	Missense_Mutation	SNP	A	A	G			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr18:55024197A>G	uc002lgn.2	+	3	713	c.356A>G	c.(355-357)AAT>AGT	p.N119S		NM_015879	NP_056963	O43173	SIA8C_HUMAN	ST8 alpha-N-acetyl-neuraminide	119	Lumenal (Potential).				glycosphingolipid biosynthetic process|N-glycan processing|post-translational protein modification|protein N-linked glycosylation via asparagine	integral to Golgi membrane	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity			breast(1)|skin(1)	2				READ - Rectum adenocarcinoma(59;0.19)|Colorectal(16;0.205)		TTGACCAAGAATAGTGTTCGG	0.333			NA											10	31					0	0	0.006214	0	0
VPS4B	9525	broad.mit.edu	37	18	61060776	61060776	+	Missense_Mutation	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr18:61060776C>T	uc002lix.2	-	10	1359	c.1099G>A	c.(1099-1101)GGA>AGA	p.G367R		NM_004869	NP_004860	O75351	VPS4B_HUMAN	vacuolar protein sorting factor 4B	367					cell cycle|cell division|cellular membrane organization|endosome to lysosome transport via multivesicular body sorting pathway|intracellular cholesterol transport|protein transport|response to lipid	cytosol|early endosome|late endosome membrane|lysosome|nucleus|vacuolar membrane	ATP binding|ATPase activity, coupled|protein C-terminus binding			ovary(1)	1						CGGGAAGGTCCGCGAACCTGA	0.388			NA											6	40					0	0	0.00308	0	0
SERPINB13	5275	broad.mit.edu	37	18	61264475	61264475	+	Missense_Mutation	SNP	G	G	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr18:61264475G>A	uc002ljc.2	+	8	1222	c.1054G>A	c.(1054-1056)GGC>AGC	p.G352S	SERPINB13_uc002ljd.2_Missense_Mutation_p.G216S|SERPINB13_uc010xep.1_Missense_Mutation_p.G361S|SERPINB13_uc010xeq.1_Missense_Mutation_p.G173S|SERPINB13_uc010xer.1_Missense_Mutation_p.G173S	NM_012397	NP_036529	Q9UIV8	SPB13_HUMAN	serine (or cysteine) proteinase inhibitor, clade	352					regulation of proteolysis|response to UV	cytoplasm|extracellular region	serine-type endopeptidase inhibitor activity			ovary(1)	1						CACCGGCATAGGCTTTACTGT	0.522			NA											10	47					0	0	0.006214	0	0
SERPINB4	6318	broad.mit.edu	37	18	61305166	61305166	+	Silent	SNP	G	G	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr18:61305166G>A	uc002ljf.2	-	8	1046	c.960C>T	c.(958-960)AGC>AGT	p.S320S	SERPINB4_uc002lje.2_Silent_p.S299S|SERPINB4_uc002ljg.2_Silent_p.S320S	NM_002974	NP_002965	P48594	SPB4_HUMAN	serine (or cysteine) proteinase inhibitor, clade	320					immune response|regulation of proteolysis	cytoplasm|extracellular region	protein binding|serine-type endopeptidase inhibitor activity			ovary(2)|lung(1)	3						AGAGACCGTGGCTCCAGGTCA	0.507			NA											10	28					0	0	0.008291	0	0
DSEL	92126	broad.mit.edu	37	18	65180123	65180123	+	Missense_Mutation	SNP	G	G	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr18:65180123G>A	uc002lke.1	-	2	2977	c.1753C>T	c.(1753-1755)CTC>TTC	p.L585F		NM_032160	NP_115536	Q8IZU8	DSEL_HUMAN	dermatan sulfate epimerase-like	575						integral to membrane	isomerase activity|sulfotransferase activity			ovary(3)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	6		Esophageal squamous(42;0.129)				GAATTTAAGAGAAGCAAAGCA	0.403			NA											4	41					0	0	0.000602	0	0
ZNF407	55628	broad.mit.edu	37	18	72346391	72346391	+	Missense_Mutation	SNP	C	C	G			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr18:72346391C>G	uc002llw.2	+	1	3473	c.3416C>G	c.(3415-3417)TCT>TGT	p.S1139C	ZNF407_uc010xfc.1_Missense_Mutation_p.S1139C|ZNF407_uc010dqu.1_Missense_Mutation_p.S1139C|ZNF407_uc002llu.2_Missense_Mutation_p.S1138C	NM_017757	NP_060227	Q9C0G0	ZN407_HUMAN	zinc finger protein 407 isoform 1	1139					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2		Esophageal squamous(42;0.131)|Prostate(75;0.173)		BRCA - Breast invasive adenocarcinoma(31;0.184)		TTAGATATGTCTAAAGTGCTC	0.358			NA											6	28					0	0	0.001168	0	0
ZNF516	9658	broad.mit.edu	37	18	74091694	74091694	+	Silent	SNP	G	G	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr18:74091694G>A	uc010dqx.1	-	3	2611	c.2376C>T	c.(2374-2376)CCC>CCT	p.P792P	ZNF516_uc002lme.2_RNA|ZNF516_uc002lmd.2_RNA	NM_014643	NP_055458	Q92618	ZN516_HUMAN	zinc finger protein 516	792					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Prostate(75;0.0869)|Esophageal squamous(42;0.129)		OV - Ovarian serous cystadenocarcinoma(15;7.64e-06)|BRCA - Breast invasive adenocarcinoma(31;0.238)		GAATCCACGGGGGAGCCACGG	0.597			NA											7	28					0	0	0.001984	0	0
SALL3	27164	broad.mit.edu	37	18	76754521	76754521	+	Nonsense_Mutation	SNP	G	G	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr18:76754521G>T	uc002lmt.2	+	2	2530	c.2530G>T	c.(2530-2532)GAG>TAG	p.E844*	SALL3_uc010dra.2_Nonsense_Mutation_p.E451*	NM_171999	NP_741996	Q9BXA9	SALL3_HUMAN	sal-like 3	844					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|large_intestine(1)|central_nervous_system(1)	4		Esophageal squamous(42;0.129)|Melanoma(33;0.16)|Prostate(75;0.167)		OV - Ovarian serous cystadenocarcinoma(15;4.69e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0256)		TGCCGCCCTGGAGAACCAGAT	0.667			NA											12	40					3.07112e-06	3.46216e-06	0.010729	1	0
CTDP1	9150	broad.mit.edu	37	18	77473099	77473099	+	Missense_Mutation	SNP	G	G	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr18:77473099G>T	uc002lnh.1	+	7	1138	c.991G>T	c.(991-993)GCG>TCG	p.A331S	CTDP1_uc002lni.1_Missense_Mutation_p.A331S|CTDP1_uc010drd.1_Missense_Mutation_p.A331S	NM_004715	NP_004706	Q9Y5B0	CTDP1_HUMAN	CTD (carboxy-terminal domain, RNA polymerase II,	331	FCP1 homology.				positive regulation of viral transcription|protein dephosphorylation|transcription elongation from RNA polymerase II promoter|viral reproduction	nucleoplasm	CTD phosphatase activity|DNA-directed RNA polymerase activity				0		Esophageal squamous(42;0.0157)|Melanoma(33;0.144)		OV - Ovarian serous cystadenocarcinoma(15;5.2e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0277)		TGATATGAATGCGCCCCCTGG	0.443			NA											6	18					0.00116845	0.00122497	0.001168	1	0
ADNP2	22850	broad.mit.edu	37	18	77894747	77894747	+	Nonsense_Mutation	SNP	C	C	G			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr18:77894747C>G	uc002lnw.2	+	4	1906	c.1451C>G	c.(1450-1452)TCA>TGA	p.S484*		NM_014913	NP_055728	Q6IQ32	ADNP2_HUMAN	ADNP homeobox 2	484					cellular response to oxidative stress|cellular response to retinoic acid|negative regulation of cell death|neuron differentiation|positive regulation of cell growth	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)|breast(3)|central_nervous_system(1)	8		all_cancers(4;1.06e-15)|all_epithelial(4;2.36e-10)|all_lung(4;0.000302)|Lung NSC(4;0.000518)|Esophageal squamous(42;0.0212)|Ovarian(4;0.0256)|all_hematologic(56;0.15)|Melanoma(33;0.2)		Epithelial(2;1.1e-11)|OV - Ovarian serous cystadenocarcinoma(15;7.54e-09)|BRCA - Breast invasive adenocarcinoma(31;0.00247)|STAD - Stomach adenocarcinoma(84;0.164)		ATGGTCCAGTCAGGAGTTCTC	0.607			NA											15	85					0	0	0.003163	0	0
PCSK4	54760	broad.mit.edu	37	19	1483437	1483437	+	Missense_Mutation	SNP	T	T	C			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr19:1483437T>C	uc002ltb.1	-	12	1479	c.1417A>G	c.(1417-1419)AGG>GGG	p.R473G	PCSK4_uc002lsz.2_5'UTR|PCSK4_uc002lta.2_Missense_Mutation_p.R285G	NM_017573	NP_060043	Q6UW60	PCSK4_HUMAN	proprotein convertase subtilisin/kexin type 4	473					proteolysis	integral to membrane	serine-type endopeptidase activity				0		Acute lymphoblastic leukemia(61;3.02e-13)|all_hematologic(61;4.32e-09)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		ACGTTTTCCCTGATGTAGATC	0.701			NA											29	23					0	0	0.004878	0	0
ZNF554	115196	broad.mit.edu	37	19	2832300	2832300	+	Splice_Site	SNP	G	G	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr19:2832300G>A	uc002lwm.2	+	4	452	c.254_splice	c.e4-1	p.E85_splice	ZNF554_uc002lwl.2_Splice_Site_p.E34_splice	NM_001102651	NP_001096121	Q86TJ5	ZN554_HUMAN	zinc finger protein 554						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GTCTTTTTCAGAAGCCTTGAA	0.348			NA											40	33					0	0	0.00623	0	0
MUC16	94025	broad.mit.edu	37	19	8982214	8982214	+	Missense_Mutation	SNP	G	G	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr19:8982214G>T	uc002mkp.2	-	70	42265	c.42061C>A	c.(42061-42063)CAT>AAT	p.H14021N	MUC16_uc010dwi.2_RNA|MUC16_uc010dwj.2_Missense_Mutation_p.H838N|MUC16_uc010xki.1_RNA	NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	14046	Extracellular (Potential).|SEA 13.			Missing (in Ref. 3; AAK74120).	cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GTGATGCCATGGGTCTGCTGG	0.632			NA											14	27					1.05317e-09	1.28397e-09	0.00245	1	0
MUC16	94025	broad.mit.edu	37	19	9072073	9072073	+	Nonsense_Mutation	SNP	C	C	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr19:9072073C>A	uc002mkp.2	-	3	15577	c.15373G>T	c.(15373-15375)GAG>TAG	p.E5125*		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	5127	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						ACATTGGTCTCTTCTGTGTTT	0.438			NA											44	53					1.59932e-28	2.22435e-28	0.007835	1	0
ANGPTL6	83854	broad.mit.edu	37	19	10205580	10205580	+	Missense_Mutation	SNP	G	G	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr19:10205580G>T	uc002mmx.1	-	3	735	c.617C>A	c.(616-618)CCG>CAG	p.P206Q	ANGPTL6_uc002mmy.1_Missense_Mutation_p.P206Q	NM_031917	NP_114123	Q8NI99	ANGL6_HUMAN	angiopoietin-like 6 precursor	206					angiogenesis|cell differentiation|signal transduction	extracellular space	receptor binding				0			OV - Ovarian serous cystadenocarcinoma(20;3.58e-08)|Epithelial(33;2.5e-05)|all cancers(31;5.96e-05)			AAGACGGACCGGAACCACAGG	0.632			NA											21	18					1.00905e-13	1.30003e-13	0.008871	1	0
KEAP1	9817	broad.mit.edu	37	19	10602328	10602328	+	Missense_Mutation	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr19:10602328C>T	uc002moq.1	-	3	1406	c.1250G>A	c.(1249-1251)GGG>GAG	p.G417E	KEAP1_uc002mop.1_Missense_Mutation_p.G135E|KEAP1_uc002mor.1_Missense_Mutation_p.G417E	NM_012289	NP_036421	Q14145	KEAP1_HUMAN	kelch-like ECH-associated protein 1	417	Kelch 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|midbody|nucleus	protein binding			lung(12)|breast(3)|ovary(1)|pancreas(1)	17			OV - Ovarian serous cystadenocarcinoma(20;2.71e-09)|Epithelial(33;2.32e-06)|all cancers(31;1.42e-05)			GACCCCCACCCCGATGCGGTT	0.667			NA											13	12					0	0	0.001855	0	0
ACP5	54	broad.mit.edu	37	19	11687567	11687568	+	Missense_Mutation	DNP	GA	GA	AT			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	GA	GA	-	-	GA	GA	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr19:11687567_11687568GA>AT	uc002msg.3	-	3	498_499	c.352_353TC>AT	c.(352-354)TCT>ATT	p.S118I	ACP5_uc002msh.3_Missense_Mutation_p.S118I|ACP5_uc002msi.3_Missense_Mutation_p.S118I|ACP5_uc002msj.3_Missense_Mutation_p.S118I|ACP5_uc010dye.1_3'UTR	NM_001611	NP_001602	P13686	PPA5_HUMAN	acid phosphatase 5, tartrate resistant	118					water-soluble vitamin metabolic process	cytosol|integral to membrane|lysosome	acid phosphatase activity|ferric iron binding|ferrous iron binding			central_nervous_system(1)	1						AATCTGGGCAGAGACATTGCCA	0.569			NA											20	97					0	0	0.004672	0	0
ZNF491	126069	broad.mit.edu	37	19	11917571	11917571	+	Missense_Mutation	SNP	A	A	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr19:11917571A>T	uc002mso.1	+	3	1088	c.803A>T	c.(802-804)GAG>GTG	p.E268V		NM_152356	NP_689569	Q8N8L2	ZN491_HUMAN	zinc finger protein 491	268					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2						CACACTGGAGAGAGGCCTCAT	0.413			NA											26	25					0	0	0.00632	0	0
ZNF799	90576	broad.mit.edu	37	19	12502558	12502558	+	Silent	SNP	C	C	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr19:12502558C>A	uc010dyt.2	-	4	804	c.654G>T	c.(652-654)ACG>ACT	p.T218T	ZNF799_uc002mts.3_Intron	NM_001080821	NP_001074290	Q96GE5	ZN799_HUMAN	zinc finger protein 799	218	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(3)|ovary(2)|skin(1)	6						CTCCAGTGTGCGTTCTCTCAT	0.403			NA											28	35					8.24728e-16	1.0847e-15	0.004656	1	0
RFX1	5989	broad.mit.edu	37	19	14077445	14077445	+	Silent	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr19:14077445C>T	uc002mxv.2	-	13	2123	c.1851G>A	c.(1849-1851)GAG>GAA	p.E617E		NM_002918	NP_002909	P22670	RFX1_HUMAN	regulatory factor X1	617					immune response	nucleus	DNA binding|protein binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity			lung(1)|pancreas(1)	2			OV - Ovarian serous cystadenocarcinoma(19;6.67e-23)			GCCACCCTACCTCACAGTGTT	0.677			NA											27	42					0	0	0.00632	0	0
CLEC17A	388512	broad.mit.edu	37	19	14710889	14710889	+	Silent	SNP	C	C	G			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr19:14710889C>G	uc010dzn.1	+	12	866	c.789C>G	c.(787-789)GGC>GGG	p.G263G	CLEC17A_uc002mzh.1_Silent_p.G246G|CLEC17A_uc010xnt.1_RNA|CLEC17A_uc010xnu.1_Intron|CLEC17A_uc010dzo.1_Silent_p.G263G			Q6ZS10	CL17A_HUMAN	SubName: Full=CLEC17A protein;	263	C-type lectin.|Extracellular (Potential).					cell surface|integral to membrane	fucose binding|mannose binding|metal ion binding|receptor activity				0						CCTTTGAGGGCAAGTGTTACT	0.532			NA											14	35					0	0	0.004007	0	0
BRD4	23476	broad.mit.edu	37	19	15366997	15366997	+	Missense_Mutation	SNP	C	C	G			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr19:15366997C>G	uc002nar.2	-	9	1851	c.1629G>C	c.(1627-1629)AAG>AAC	p.K543N	BRD4_uc002nas.2_Missense_Mutation_p.K543N|BRD4_uc002nat.3_Missense_Mutation_p.K543N|BRD4_uc002nau.3_Missense_Mutation_p.K543N	NM_058243	NP_490597	O60885	BRD4_HUMAN	bromodomain-containing protein 4 isoform long	543	Lys-rich.				interspecies interaction between organisms|positive regulation of G2/M transition of mitotic cell cycle|positive regulation of transcription elongation from RNA polymerase II promoter|regulation of transcription involved in G1 phase of mitotic cell cycle	condensed nuclear chromosome|cytoplasm	protein binding			ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(3;3.02e-24)|Epithelial(3;4.71e-20)|all cancers(3;2.26e-18)			tcttttccttcttgtctttct	0.199			NA	T	NUT|C15orf55	lethal midline carcinoma of young people								17	52					0	0	0.004007	0	0
CYP4F3	4051	broad.mit.edu	37	19	15756552	15756552	+	Silent	SNP	C	C	G			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr19:15756552C>G	uc002nbj.2	+	3	272	c.222C>G	c.(220-222)CTC>CTG	p.L74L	CYP4F3_uc010xok.1_Intron|CYP4F3_uc010xol.1_Intron|CYP4F3_uc010xom.1_Intron|CYP4F3_uc002nbk.2_Intron	NM_000896	NP_000887	Q08477	CP4F3_HUMAN	cytochrome P450, family 4, subfamily F,	74					leukotriene metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	electron carrier activity|heme binding|leukotriene-B4 20-monooxygenase activity|oxygen binding			ovary(3)	3						AGGAAGGTCTCCTATACACAC	0.557			NA											13	88					0	0	0.00245	0	0
FCHO1	23149	broad.mit.edu	37	19	17893966	17893966	+	Missense_Mutation	SNP	C	C	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr19:17893966C>A	uc010ebb.2	+	23	2267	c.2078C>A	c.(2077-2079)GCC>GAC	p.A693D	FCHO1_uc002nhg.3_Missense_Mutation_p.A693D|FCHO1_uc002nhh.2_Missense_Mutation_p.A693D|FCHO1_uc010xpw.1_Missense_Mutation_p.A643D|FCHO1_uc002nhi.2_Missense_Mutation_p.A149D|FCHO1_uc002nhj.2_Missense_Mutation_p.A37D	NM_001161358	NP_001154830	O14526	FCHO1_HUMAN	FCH domain only 1 isoform b	693										breast(1)	1						CAGCCCAACGCCGATCTGCTG	0.617			NA											25	30					6.12954e-19	8.24082e-19	0.004656	1	0
KCNN1	3780	broad.mit.edu	37	19	18092827	18092827	+	Missense_Mutation	SNP	A	A	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr19:18092827A>T	uc002nht.2	+	5	1118	c.808A>T	c.(808-810)ACG>TCG	p.T270S	KCNN1_uc010xqa.1_Missense_Mutation_p.T270S	NM_002248	NP_002239	Q92952	KCNN1_HUMAN	potassium intermediate/small conductance	270					synaptic transmission	voltage-gated potassium channel complex	calmodulin binding|small conductance calcium-activated potassium channel activity				0						CACCTTCAACACGCGCTTCGT	0.612			NA											3	10					0	0	0.004672	0	0
ZNF93	81931	broad.mit.edu	37	19	20045245	20045245	+	Missense_Mutation	SNP	C	C	G			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr19:20045245C>G	uc002non.2	+	4	1592	c.1481C>G	c.(1480-1482)TCT>TGT	p.S494C		NM_031218	NP_112495	P35789	ZNF93_HUMAN	zinc finger protein 93	494	C2H2-type 13.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			pancreas(1)	1						AACCAGTCCTCTTCCCTTACT	0.368			NA											4	24					0	0	0.009096	0	0
ZNF682	91120	broad.mit.edu	37	19	20118030	20118030	+	Missense_Mutation	SNP	G	G	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr19:20118030G>A	uc002noq.2	-	4	404	c.281C>T	c.(280-282)TCA>TTA	p.S94L	ZNF682_uc002noo.2_Missense_Mutation_p.S62L|ZNF682_uc002nop.2_Missense_Mutation_p.S62L|ZNF682_uc010eck.2_Missense_Mutation_p.S18L	NM_033196	NP_149973	O95780	ZN682_HUMAN	zinc finger protein 682 isoform 1	94					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|pancreas(1)	2						TTTTTGGAATGAATCTTGCAT	0.368			NA											5	19					0	0	0.000602	0	0
ZNF676	163223	broad.mit.edu	37	19	22363185	22363185	+	Missense_Mutation	SNP	C	C	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr19:22363185C>A	uc002nqs.1	-	3	1652	c.1334G>T	c.(1333-1335)GGA>GTA	p.G445V		NM_001001411	NP_001001411	Q8N7Q3	ZN676_HUMAN	zinc finger protein 676	445					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.114)				GGGTTTCTCTCCAGCATGAAT	0.428			NA											18	47					9.16793e-09	1.10106e-08	0.00499	1	0
ZNF254	9534	broad.mit.edu	37	19	24310356	24310356	+	Nonsense_Mutation	SNP	C	C	G			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr19:24310356C>G	uc002nru.2	+	4	1688	c.1554C>G	c.(1552-1554)TAC>TAG	p.Y518*	ZNF254_uc010xrk.1_Nonsense_Mutation_p.Y433*	NM_203282	NP_975011	O75437	ZN254_HUMAN	zinc finger protein 254	518	C2H2-type 12.				negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_cancers(12;0.086)|all_lung(12;0.00528)|Lung NSC(12;0.00731)|all_epithelial(12;0.0186)				AGAAACCCTACAAATGTGAAG	0.368			NA											14	15					0	0	0.00245	0	0
TSHZ3	57616	broad.mit.edu	37	19	31769448	31769448	+	Silent	SNP	A	A	G			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr19:31769448A>G	uc002nsy.3	-	2	1316	c.1251T>C	c.(1249-1251)TCT>TCC	p.S417S		NM_020856	NP_065907	Q63HK5	TSH3_HUMAN	zinc finger protein 537	417					negative regulation of transcription, DNA-dependent|regulation of respiratory gaseous exchange by neurological system process	growth cone|nucleus	chromatin binding|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)|skin(2)|pancreas(1)|lung(1)	8	Esophageal squamous(110;0.226)					TTTTCATAGCAGAGTTGGTGA	0.567			NA											50	113					0	0	0.01441	0	0
MAG	4099	broad.mit.edu	37	19	35804322	35804322	+	Missense_Mutation	SNP	G	G	C			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr19:35804322G>C	uc002nyy.1	+	11	1995	c.1846G>C	c.(1846-1848)GAG>CAG	p.E616Q	MAG_uc002nyx.1_3'UTR|MAG_uc010eds.1_Missense_Mutation_p.E591Q|MAG_uc002nyz.1_Missense_Mutation_p.E616Q	NM_002361	NP_002352	P20916	MAG_HUMAN	myelin associated glycoprotein isoform a	616	Cytoplasmic (Potential).				blood coagulation|cell adhesion|leukocyte migration|negative regulation of axonogenesis|nerve growth factor receptor signaling pathway	integral to membrane|plasma membrane	sugar binding			breast(3)|lung(2)|central_nervous_system(1)|skin(1)	7	all_lung(56;2.37e-08)|Lung NSC(56;3.66e-08)|Esophageal squamous(110;0.162)	Renal(1328;0.242)	Epithelial(14;3.14e-19)|OV - Ovarian serous cystadenocarcinoma(14;1.5e-18)|all cancers(14;1.5e-16)|LUSC - Lung squamous cell carcinoma(66;0.0417)			GCTGACGGAGGAGCTAGCTGA	0.652			NA											12	50					0	0	0.010729	0	0
ZBTB32	27033	broad.mit.edu	37	19	36205667	36205667	+	Silent	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr19:36205667C>T	uc002oay.2	+	2	349	c.139C>T	c.(139-141)CTA>TTA	p.L47L	ZBTB32_uc002oaz.2_RNA	NM_014383	NP_055198	Q9Y2Y4	ZBT32_HUMAN	zinc finger and BTB domain containing 32	47	BTB.				DNA repair|negative regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleoplasm	DNA binding|protein binding|transcription corepressor activity|zinc ion binding			ovary(1)|skin(1)	2	all_lung(56;2.22e-07)|Lung NSC(56;3.47e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			CAGCCTGGTGCTAGCAGGTGT	0.622			NA											19	91					0	0	0.008871	0	0
NFKBID	84807	broad.mit.edu	37	19	36387833	36387833	+	Missense_Mutation	SNP	T	T	C			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr19:36387833T>C	uc002oci.1	-	5	708	c.134A>G	c.(133-135)CAG>CGG	p.Q45R	NFKBID_uc002och.1_5'Flank|NFKBID_uc002ocj.1_Missense_Mutation_p.Q60R	NM_139239	NP_640332	Q8NI38	IKBD_HUMAN	nuclear factor of kappa light polypeptide gene	45					inflammatory response	nucleus					0						CTCCTCATCCTGGGCCAGCAG	0.637			NA											4	113					0	0	0.009096	0	0
ZNF607	84775	broad.mit.edu	37	19	38190715	38190715	+	Missense_Mutation	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr19:38190715C>T	uc002ohc.1	-	5	913	c.317G>A	c.(316-318)AGA>AAA	p.R106K	ZNF607_uc002ohb.1_Missense_Mutation_p.R105K	NM_032689	NP_116078	Q96SK3	ZN607_HUMAN	zinc finger protein 607	106					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0			UCEC - Uterine corpus endometrioid carcinoma (49;0.0775)			ATTATGAATTCTCTGATGGAG	0.348			NA											9	46					0	0	0.004482	0	0
RYR1	6261	broad.mit.edu	37	19	38934893	38934893	+	Missense_Mutation	SNP	C	C	G			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr19:38934893C>G	uc002oit.2	+	6	659	c.529C>G	c.(529-531)CGC>GGC	p.R177G	RYR1_uc002oiu.2_Missense_Mutation_p.R177G	NM_000540	NP_000531	P21817	RYR1_HUMAN	skeletal muscle ryanodine receptor isoform 1	177	Cytoplasmic.|MIR 2.		R -> C (in MHS1).		muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(7)|pancreas(2)|breast(1)|central_nervous_system(1)|skin(1)	12	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	CTCCTCCGAGCGCTACCTGGT	0.602			NA											5	36					0	0	0.000602	0	0
ZFP36	7538	broad.mit.edu	37	19	39898382	39898382	+	Splice_Site	SNP	G	G	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr19:39898382G>T	uc002olh.1	+	2	83	c.25_splice	c.e2-1	p.S9_splice	ZFP36_uc010egn.1_Intron	NM_003407	NP_003398	P26651	TTP_HUMAN	zinc finger protein 36, C3H type, homolog						positive regulation of nuclear-transcribed mRNA poly(A) tail shortening	cytosol|nucleus	AU-rich element binding|DNA binding|mRNA binding|protein binding|single-stranded RNA binding|zinc ion binding			pancreas(1)	1	all_cancers(60;6.54e-07)|all_lung(34;4.03e-08)|Lung NSC(34;4.66e-08)|all_epithelial(25;1.53e-06)|Ovarian(47;0.0512)		Epithelial(26;2.92e-26)|all cancers(26;2.01e-23)|Lung(45;0.000499)|LUSC - Lung squamous cell carcinoma(53;0.000657)			CATTTCCGCAGAGCCTCCTGT	0.672	NSCLC(67;1164 1324 12056 21056 30097)		NA											121	229					9.11594e-60	1.28508e-59	0.01441	1	0
PLEKHG2	64857	broad.mit.edu	37	19	39914254	39914254	+	Nonsense_Mutation	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr19:39914254C>T	uc010xuz.1	+	18	2885	c.2560C>T	c.(2560-2562)CAG>TAG	p.Q854*	PLEKHG2_uc010xuy.1_Nonsense_Mutation_p.Q795*|PLEKHG2_uc002olj.2_Intron|PLEKHG2_uc010xva.1_Nonsense_Mutation_p.Q632*	NM_022835	NP_073746	Q9H7P9	PKHG2_HUMAN	common-site lymphoma/leukemia guanine nucleotide	854					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity			skin(2)|pancreas(1)|breast(1)	4	all_cancers(60;3.08e-07)|all_lung(34;2.66e-08)|Lung NSC(34;3e-08)|all_epithelial(25;6.57e-07)|Ovarian(47;0.0569)		Epithelial(26;2.92e-26)|all cancers(26;2.01e-23)|Lung(45;0.000499)|LUSC - Lung squamous cell carcinoma(53;0.000657)			GGCCCAACCCCAGCCATCCCC	0.692			NA											11	21					0	0	0.008291	0	0
FCGBP	8857	broad.mit.edu	37	19	40367841	40367841	+	Silent	SNP	T	T	G			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr19:40367841T>G	uc002omp.3	-	29	13127	c.13119A>C	c.(13117-13119)GCA>GCC	p.A4373A		NM_003890	NP_003881	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein precursor	4373	TIL 10.					extracellular region	protein binding			ovary(4)|skin(4)|central_nervous_system(1)	9	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			TCGTAAGGGGTGCAGGGGACG	0.627			NA											7	53					0	0	0.003954	0	0
CYP2B6	1555	broad.mit.edu	37	19	41509988	41509988	+	Missense_Mutation	SNP	G	G	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr19:41509988G>A	uc002opr.1	+	2	261	c.254G>A	c.(253-255)CGG>CAG	p.R85Q	CYP2A7_uc002opo.2_Intron|CYP2B6_uc010xvu.1_Missense_Mutation_p.R45Q	NM_000767	NP_000758	P20813	CP2B6_HUMAN	cytochrome P450, family 2, subfamily B,	85					cellular ketone metabolic process|exogenous drug catabolic process|steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding			ovary(1)|skin(1)	2			LUSC - Lung squamous cell carcinoma(20;0.00322)		Bupropion(DB01156)|Butalbital(DB00241)|Carbamazepine(DB00564)|Clopidogrel(DB00758)|Cyclophosphamide(DB00531)|Efavirenz(DB00625)|Ifosfamide(DB01181)|Memantine(DB01043)|Meperidine(DB00454)|Mephenytoin(DB00532)|Methadone(DB00333)|Methylphenobarbital(DB00849)|Midazolam(DB00683)|Nelfinavir(DB00220)|Nevirapine(DB00238)|Nicotine(DB00184)|Orphenadrine(DB01173)|Phenytoin(DB00252)|Propofol(DB00818)|Ritonavir(DB00503)|Selegiline(DB01037)|Sertraline(DB01104)|Ticlopidine(DB00208)|Troleandomycin(DB01361)	GAGGCCATACGGGAGGCCCTT	0.582			NA											20	99					0	0	0.008871	0	0
ARHGEF1	9138	broad.mit.edu	37	19	42407924	42407924	+	Silent	SNP	G	G	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr19:42407924G>T	uc002orx.2	+	20	2014	c.1905G>T	c.(1903-1905)CTG>CTT	p.L635L	ARHGEF1_uc002ory.2_Silent_p.L602L|ARHGEF1_uc002orz.2_Silent_p.L473L|ARHGEF1_uc002osa.2_Silent_p.L650L|ARHGEF1_uc002osb.2_Silent_p.L617L|ARHGEF1_uc002osc.2_Silent_p.L389L|ARHGEF1_uc002osd.2_Silent_p.L294L|ARHGEF1_uc002ose.2_Silent_p.L79L	NM_004706	NP_004697	Q92888	ARHG1_HUMAN	Rho guanine nucleotide exchange factor 1 isoform	635					cell proliferation|negative regulation of axonogenesis|nerve growth factor receptor signaling pathway|positive regulation of axonogenesis|regulation of Rho protein signal transduction|Rho protein signal transduction	cytosol|plasma membrane	GTPase activator activity|protein binding|Rho guanyl-nucleotide exchange factor activity			ovary(3)|large_intestine(1)	4		Renal(1328;0.000518)|Hepatocellular(1079;0.0046)|Medulloblastoma(540;0.0425)		Epithelial(262;5.89e-46)|GBM - Glioblastoma multiforme(1328;2.49e-12)|STAD - Stomach adenocarcinoma(1328;0.00644)		ACCCTATGCTGAGCGAGTTCA	0.627			NA											21	36					1.90627e-21	2.58441e-21	0.012319	1	0
POU2F2	5452	broad.mit.edu	37	19	42621437	42621437	+	Missense_Mutation	SNP	C	C	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr19:42621437C>A	uc002osp.2	-	5	335	c.268G>T	c.(268-270)GCC>TCC	p.A90S	POU2F2_uc002osn.2_Missense_Mutation_p.A90S|POU2F2_uc002oso.2_5'UTR|POU2F2_uc002osq.2_Missense_Mutation_p.A90S|POU2F2_uc002osr.1_Missense_Mutation_p.A90S	NM_002698	NP_002689	P09086	PO2F2_HUMAN	POU domain, class 2, transcription factor 2	90					humoral immune response|transcription from RNA polymerase II promoter	cytoplasm|nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|skin(1)	2		Prostate(69;0.059)				ATGAGTTGGGCCTGGGGCAGA	0.642			NA											30	105					7.01153e-11	8.67924e-11	0.007291	1	0
ZNF526	116115	broad.mit.edu	37	19	42730041	42730041	+	Missense_Mutation	SNP	G	G	C			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr19:42730041G>C	uc002osz.1	+	3	1642	c.1486G>C	c.(1486-1488)GGT>CGT	p.G496R		NM_133444	NP_597701	Q8TF50	ZN526_HUMAN	zinc finger protein 526	496					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Prostate(69;0.0704)				GACACACACGGGTGAGAGGCC	0.617			NA											19	86					0	0	0.006122	0	0
CIC	23152	broad.mit.edu	37	19	42791043	42791043	+	Missense_Mutation	SNP	G	G	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr19:42791043G>T	uc002otf.1	+	2	228	c.188G>T	c.(187-189)AGC>ATC	p.S63I		NM_015125	NP_055940	Q96RK0	CIC_HUMAN	capicua homolog	63	Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding			ovary(4)|breast(4)|lung(1)|central_nervous_system(1)|skin(1)	11		Prostate(69;0.00682)				CAACCTGCCAGCCACCCAGTG	0.667			NA	T	DUX4	soft tissue sarcoma								15	41					2.31682e-05	2.54658e-05	0.003163	1	0
PSG11	5680	broad.mit.edu	37	19	43530537	43530537	+	Translation_Start_Site	SNP	G	G	A	rs1064913		TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr19:43530537G>A	uc002ovm.1	-	1	95	c.-12C>T	c.(-14--10)CACGC>CATGC		PSG11_uc002ouw.2_Silent_p.H2H|PSG10_uc002ouv.1_Intron|PSG6_uc002ovh.1_Silent_p.H2H|PSG6_uc002ovi.2_Intron|PSG6_uc010xwk.1_Intron|PSG11_uc002ovk.1_Silent_p.H2H|PSG11_uc002ovn.1_Silent_p.H2H|PSG11_uc002ovo.1_Translation_Start_Site|PSG11_uc002ovp.1_Translation_Start_Site	NM_002785	NP_002776	Q9UQ72	PSG11_HUMAN	pregnancy specific beta-1-glycoprotein 11						female pregnancy	extracellular region					0		Prostate(69;0.00682)				TCTCTGCTGCGTGCATGTTCT	0.582			NA											39	20					0	0	0.004878	0	0
PSG2	5670	broad.mit.edu	37	19	43576091	43576092	+	Missense_Mutation	DNP	GG	GG	TT			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr19:43576091_43576092GG>TT	uc002ovr.2	-	4	817_818	c.724_725CC>AA	c.(724-726)CCC>AAC	p.P242N	PSG6_uc002ovi.2_Intron|PSG6_uc010xwk.1_Intron|PSG2_uc002ovq.3_Missense_Mutation_p.P242N|PSG2_uc010eiq.1_Missense_Mutation_p.P242N|PSG2_uc002ovs.3_Missense_Mutation_p.P242N|PSG2_uc002ovt.3_Missense_Mutation_p.P242N	NM_031246	NP_112536	P11465	PSG2_HUMAN	pregnancy specific beta-1-glycoprotein 2	242	Ig-like C2-type 2.				cell migration|female pregnancy	extracellular region					0		Prostate(69;0.00682)				GTGAATTCTGGGGAGGTCTGGA	0.495			NA											27	93					0	0	0.004672	0	0
PHLDB3	653583	broad.mit.edu	37	19	44006403	44006403	+	Silent	SNP	G	G	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr19:44006403G>A	uc002own.3	-	3	505	c.246C>T	c.(244-246)GCC>GCT	p.A82A	PHLDB3_uc002owo.2_Silent_p.A82A	NM_198850	NP_942147	Q6NSJ2	PHLB3_HUMAN	pleckstrin homology-like domain, family B,	82											0		Prostate(69;0.0153)				CGGGAGGTGTGGCCGCCATAG	0.652			NA											3	3					0	0	0.004672	0	0
IRGQ	126298	broad.mit.edu	37	19	44096300	44096300	+	Missense_Mutation	SNP	C	C	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr19:44096300C>A	uc002oww.2	-	2	1868	c.1750G>T	c.(1750-1752)GGT>TGT	p.G584C	IRGQ_uc010eiv.2_Missense_Mutation_p.G584C	NM_001007561	NP_001007562	Q8WZA9	IRGQ_HUMAN	immunity-related GTPase family, Q	584	Ala-rich.						protein binding			ovary(1)|pancreas(1)	2		Prostate(69;0.0199)				GCTGCACCACCCGCAGGCCAC	0.716			NA											11	51					3.07112e-06	3.46216e-06	0.010729	1	0
GEMIN7	79760	broad.mit.edu	37	19	45593530	45593530	+	Missense_Mutation	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr19:45593530C>T	uc002pap.1	+	3	309	c.158C>T	c.(157-159)TCC>TTC	p.S53F	uc002pas.2_5'Flank|GEMIN7_uc002paq.1_Missense_Mutation_p.S53F|GEMIN7_uc002par.1_Missense_Mutation_p.S53F	NM_001007270	NP_001007271	Q9H840	GEMI7_HUMAN	gemin 7	53					ncRNA metabolic process|spliceosomal snRNP assembly	Cajal body|cytosol|spliceosomal complex	protein binding			ovary(1)	1		Ovarian(192;0.0728)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.0131)		TCCCTGGAATCCCAGGAGCAG	0.627			NA											13	71					0	0	0.013537	0	0
GPR4	2828	broad.mit.edu	37	19	46094344	46094344	+	Nonsense_Mutation	SNP	C	C	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr19:46094344C>A	uc002pcm.2	-	2	1726	c.781G>T	c.(781-783)GAG>TAG	p.E261*	OPA3_uc010xxk.1_Intron	NM_005282	NP_005273	P46093	GPR4_HUMAN	G protein-coupled receptor 4	261	Extracellular (Potential).					integral to plasma membrane	G-protein coupled receptor activity			ovary(2)	2				OV - Ovarian serous cystadenocarcinoma(262;0.0071)|GBM - Glioblastoma multiforme(486;0.128)|Epithelial(262;0.223)		ACGCGCTCCTCGAAGCCGCAG	0.637	Esophageal Squamous(117;181 1612 1673 14956 42937)		NA											29	49					9.39395e-14	1.21352e-13	0.00632	1	0
IRF2BP1	26145	broad.mit.edu	37	19	46387917	46387917	+	Silent	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr19:46387917C>T	uc002pds.1	-	1	1460	c.1116G>A	c.(1114-1116)CGG>CGA	p.R372R		NM_015649	NP_056464	Q8IU81	I2BP1_HUMAN	interferon regulatory factor 2 binding protein	372					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus					0		all_neural(266;0.113)|Ovarian(192;0.127)		OV - Ovarian serous cystadenocarcinoma(262;0.00442)|GBM - Glioblastoma multiforme(486;0.0402)|Epithelial(262;0.231)		GCGCCAGGTTCCGGGATGGGG	0.751			NA											5	25					0	0	0.000602	0	0
NOVA2	4858	broad.mit.edu	37	19	46443465	46443465	+	Missense_Mutation	SNP	C	C	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr19:46443465C>A	uc002pdv.2	-	4	1183	c.1135G>T	c.(1135-1137)GGC>TGC	p.G379C		NM_002516	NP_002507	Q9UNW9	NOVA2_HUMAN	neuro-oncological ventral antigen 2	379	Ala-rich.|Gly-rich.					nucleus	RNA binding				0		all_neural(266;0.113)|Ovarian(192;0.127)		OV - Ovarian serous cystadenocarcinoma(262;0.00245)|GBM - Glioblastoma multiforme(486;0.0782)|Epithelial(262;0.179)		accagcgggccgccccctccg	0.343			NA											5	9					3.59834e-05	3.94026e-05	0.001168	1	0
PRKD2	25865	broad.mit.edu	37	19	47193890	47193890	+	Missense_Mutation	SNP	C	C	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr19:47193890C>A	uc002pfh.2	-	14	2118	c.1776G>T	c.(1774-1776)GAG>GAT	p.E592D	PRKD2_uc002pfd.2_5'Flank|PRKD2_uc010eks.2_5'UTR|PRKD2_uc010ekt.2_5'UTR|PRKD2_uc002pfe.2_Missense_Mutation_p.E112D|PRKD2_uc002pff.2_Missense_Mutation_p.E112D|PRKD2_uc002pfg.2_Missense_Mutation_p.E435D|PRKD2_uc002pfi.2_Missense_Mutation_p.E592D|PRKD2_uc002pfj.2_Missense_Mutation_p.E592D|PRKD2_uc010xye.1_Missense_Mutation_p.E592D|PRKD2_uc002pfk.2_Missense_Mutation_p.E435D	NM_001079881	NP_001073350	Q9BZL6	KPCD2_HUMAN	protein kinase D2 isoform A	592	Protein kinase.				cell death|intracellular signal transduction|positive regulation of transcription from RNA polymerase II promoter|protein autophosphorylation|T cell receptor signaling pathway	cytoplasm|membrane|nucleus	ATP binding|metal ion binding|protein kinase C activity			ovary(2)|central_nervous_system(2)|stomach(1)|large_intestine(1)|lung(1)	7		Ovarian(192;0.0129)|all_neural(266;0.0459)|Breast(70;0.212)		OV - Ovarian serous cystadenocarcinoma(262;0.000189)|all cancers(93;0.000545)|Epithelial(262;0.0219)|GBM - Glioblastoma multiforme(486;0.0353)		GGAGCTGGCTCTCCTGCTTGG	0.517			NA											16	92					2.35188e-11	2.94391e-11	0.006122	1	0
PLA2G4C	8605	broad.mit.edu	37	19	48578088	48578088	+	Silent	SNP	G	G	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr19:48578088G>A	uc002phx.2	-	12	1340	c.942C>T	c.(940-942)CTC>CTT	p.L314L	PLA2G4C_uc002phw.2_Silent_p.L249L|PLA2G4C_uc010elr.2_Silent_p.L314L|PLA2G4C_uc010xzd.1_Silent_p.L324L	NM_003706	NP_003697	Q9UP65	PA24C_HUMAN	phospholipase A2, group IVC isoform 1 precursor	314	PLA2c.				arachidonic acid metabolic process|glycerophospholipid catabolic process|inflammatory response|intracellular signal transduction|parturition	cytosol|membrane	calcium-independent phospholipase A2 activity|phospholipid binding			ovary(1)|skin(1)	2		all_cancers(25;2.84e-05)|all_lung(116;4.62e-05)|Lung NSC(112;7.61e-05)|all_epithelial(76;0.000192)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;8.09e-05)|all cancers(93;0.000517)|Epithelial(262;0.0135)|GBM - Glioblastoma multiforme(486;0.0717)		TCCAATTCTCGAGCATCTCAG	0.512			NA											35	160					0	0	0.003271	0	0
PLEKHA4	57664	broad.mit.edu	37	19	49340593	49340593	+	Missense_Mutation	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr19:49340593C>T	uc002pkx.2	-	20	2844	c.2293G>A	c.(2293-2295)GAG>AAG	p.E765K	HSD17B14_uc002pkv.1_5'Flank|HSD17B14_uc010emk.1_5'Flank|PLEKHA4_uc002pkw.1_3'UTR|PLEKHA4_uc010eml.2_3'UTR	NM_020904	NP_065955	Q9H4M7	PKHA4_HUMAN	pleckstrin homology domain containing family A	765						cytoplasm|membrane	1-phosphatidylinositol binding			ovary(1)|central_nervous_system(1)|skin(1)	3		all_lung(116;4.89e-05)|Lung NSC(112;8.3e-05)|all_epithelial(76;0.000108)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.00027)|all cancers(93;0.00084)|GBM - Glioblastoma multiforme(486;0.0244)|Epithelial(262;0.0364)		CATGCCCCCTCGTCTTGTGGC	0.677			NA											14	65					0	0	0.003163	0	0
PLEKHA4	57664	broad.mit.edu	37	19	49357336	49357336	+	Silent	SNP	C	C	G			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr19:49357336C>G	uc002pkx.2	-	11	1655	c.1104G>C	c.(1102-1104)CTG>CTC	p.L368L	PLEKHA4_uc002pkw.1_5'UTR|PLEKHA4_uc010eml.2_Silent_p.L343L	NM_020904	NP_065955	Q9H4M7	PKHA4_HUMAN	pleckstrin homology domain containing family A	368						cytoplasm|membrane	1-phosphatidylinositol binding			ovary(1)|central_nervous_system(1)|skin(1)	3		all_lung(116;4.89e-05)|Lung NSC(112;8.3e-05)|all_epithelial(76;0.000108)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.00027)|all cancers(93;0.00084)|GBM - Glioblastoma multiforme(486;0.0244)|Epithelial(262;0.0364)		ACAACTTGGTCAGCAGCGTCT	0.617			NA											4	53					0	0	0.009096	0	0
PTOV1	53635	broad.mit.edu	37	19	50360333	50360333	+	Silent	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr19:50360333C>T	uc002pqf.1	+	6	830	c.660C>T	c.(658-660)TAC>TAT	p.Y220Y	PTOV1_uc002ppz.3_RNA|PTOV1_uc002pqb.3_Silent_p.Y188Y|PTOV1_uc002pqa.2_RNA|PTOV1_uc002pqc.1_RNA|PTOV1_uc002pqd.2_RNA|PTOV1_uc002pqe.1_RNA	NM_017432	NP_059128	Q86YD1	PTOV1_HUMAN	prostate tumor overexpressed 1	220	Interaction with FLOT1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|perinuclear region of cytoplasm|plasma membrane					0		all_lung(116;1.05e-05)|Lung NSC(112;3.77e-05)|all_neural(266;0.107)|Ovarian(192;0.231)		GBM - Glioblastoma multiforme(134;0.0116)|OV - Ovarian serous cystadenocarcinoma(262;0.0132)		TCATCCCCTACGACCAGAGCG	0.617			NA											56	244					0	0	0.01441	0	0
PNKP	11284	broad.mit.edu	37	19	50368512	50368512	+	Missense_Mutation	SNP	G	G	C			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr19:50368512G>C	uc002pqh.2	-	3	422	c.370C>G	c.(370-372)CTG>GTG	p.L124V	PNKP_uc002pqg.2_5'UTR|PNKP_uc002pqi.2_Missense_Mutation_p.L85V|PNKP_uc002pqj.2_Missense_Mutation_p.L124V|PNKP_uc010enm.2_Missense_Mutation_p.L124V|PNKP_uc002pqk.2_Missense_Mutation_p.L124V	NM_007254	NP_009185	Q96T60	PNKP_HUMAN	polynucleotide kinase 3' phosphatase	124					DNA damage response, detection of DNA damage|DNA-dependent DNA replication|nucleotide-excision repair, DNA damage removal|response to oxidative stress|response to radiation	nucleolus	ATP binding|ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity|damaged DNA binding|double-stranded DNA binding|endonuclease activity|nucleotide kinase activity|polynucleotide 3'-phosphatase activity|protein binding			ovary(1)|kidney(1)	2		all_lung(116;1.05e-05)|Lung NSC(112;3.77e-05)|all_neural(266;0.107)|Ovarian(192;0.231)		GBM - Glioblastoma multiforme(134;0.0118)|OV - Ovarian serous cystadenocarcinoma(262;0.0134)		TGGGACACCAGAGGGGTGCCA	0.572			NA						Other_BER_factors					12	55					0	0	0.013537	0	0
ZNF473	25888	broad.mit.edu	37	19	50549823	50549823	+	Missense_Mutation	SNP	G	G	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr19:50549823G>A	uc002prn.2	+	5	2360	c.2123G>A	c.(2122-2124)GGG>GAG	p.G708E	ZNF473_uc002prm.2_Missense_Mutation_p.G708E|ZNF473_uc010ybo.1_Missense_Mutation_p.G696E	NM_001006656	NP_001006657	Q8WTR7	ZN473_HUMAN	zinc finger protein 473	708	C2H2-type 15.				histone mRNA 3'-end processing|regulation of transcription, DNA-dependent|termination of RNA polymerase II transcription	Cajal body	DNA binding|protein binding|zinc ion binding			ovary(1)|central_nervous_system(1)	2		all_neural(266;0.0459)|Ovarian(192;0.0728)		GBM - Glioblastoma multiforme(134;0.00111)|OV - Ovarian serous cystadenocarcinoma(262;0.0058)		AACGAATGCGGGAAAACGTTC	0.483			NA											16	72					0	0	0.004007	0	0
MYBPC2	4606	broad.mit.edu	37	19	50945490	50945490	+	Silent	SNP	C	C	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr19:50945490C>A	uc002psf.2	+	9	873	c.822C>A	c.(820-822)ATC>ATA	p.I274I		NM_004533	NP_004524	Q14324	MYPC2_HUMAN	myosin binding protein C, fast type	274	Ig-like C2-type 2.				cell adhesion|muscle filament sliding	cytosol|myosin filament	actin binding|structural constituent of muscle			breast(1)	1		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.0079)|GBM - Glioblastoma multiforme(134;0.0144)		GCAACAAGATCAAGTTGATGG	0.522			NA											5	7					4.096e-09	4.96443e-09	0.001168	1	0
CD33	945	broad.mit.edu	37	19	51738435	51738435	+	Missense_Mutation	SNP	G	G	T	rs1051198		TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr19:51738435G>T	uc002pwa.2	+	5	809	c.769G>T	c.(769-771)GTG>TTG	p.V257L	CD33_uc010eos.1_Missense_Mutation_p.V257L|CD33_uc010eot.1_Missense_Mutation_p.V130L|CD33_uc010eou.1_RNA	NM_001772	NP_001763	P20138	CD33_HUMAN	CD33 antigen isoform 1 precursor	257	Extracellular (Potential).				cell adhesion|cell-cell signaling|negative regulation of cell proliferation	external side of plasma membrane|integral to plasma membrane	receptor activity|sugar binding				0		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000224)|OV - Ovarian serous cystadenocarcinoma(262;0.00468)	Gemtuzumab ozogamicin(DB00056)	CAGAGCAGGAGTGGTTCATGG	0.483			NA											17	40					3.51602e-12	4.45874e-12	0.008871	1	0
CD33	945	broad.mit.edu	37	19	51742776	51742776	+	Missense_Mutation	SNP	C	C	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr19:51742776C>A	uc002pwa.2	+	7	968	c.928C>A	c.(928-930)CAC>AAC	p.H310N	CD33_uc010eos.1_3'UTR|CD33_uc010eot.1_Missense_Mutation_p.H183N|CD33_uc010eou.1_RNA	NM_001772	NP_001763	P20138	CD33_HUMAN	CD33 antigen isoform 1 precursor	310	Cytoplasmic (Potential).				cell adhesion|cell-cell signaling|negative regulation of cell proliferation	external side of plasma membrane|integral to plasma membrane	receptor activity|sugar binding				0		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000224)|OV - Ovarian serous cystadenocarcinoma(262;0.00468)	Gemtuzumab ozogamicin(DB00056)	CCATAAGAAACACCAGAAGAA	0.512			NA											11	16					3.86212e-05	4.21639e-05	0.008291	1	0
SIGLEC12	89858	broad.mit.edu	37	19	51994903	51994903	+	Missense_Mutation	SNP	G	G	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr19:51994903G>T	uc002pwx.1	-	8	1836	c.1780C>A	c.(1780-1782)CCC>ACC	p.P594T	SIGLEC12_uc002pww.1_Missense_Mutation_p.P476T|SIGLEC12_uc010eoy.1_Missense_Mutation_p.P321T	NM_053003	NP_443729	Q96PQ1	SIG12_HUMAN	sialic acid binding immunoglobulin-like	594	Cytoplasmic (Potential).				cell adhesion	integral to membrane	sugar binding			ovary(3)|skin(2)	5		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.00161)|OV - Ovarian serous cystadenocarcinoma(262;0.0102)		TCTCACTTGGGGATGTTGATC	0.522			NA											39	72					9.39024e-22	1.27546e-21	0.009718	1	0
SIGLEC14	100049587	broad.mit.edu	37	19	52147285	52147285	+	Silent	SNP	C	C	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr19:52147285C>A	uc002pxf.3	-	5	879	c.759G>T	c.(757-759)CTG>CTT	p.L253L		NM_001098612	NP_001092082	Q08ET2	SIG14_HUMAN	sialic acid binding Ig-like lectin 14 precursor	253	Extracellular (Potential).|Ig-like C2-type 2.				cell adhesion	integral to membrane|plasma membrane	protein binding|sugar binding			ovary(1)	1		all_neural(266;0.0299)		GBM - Glioblastoma multiforme(134;0.000965)|OV - Ovarian serous cystadenocarcinoma(262;0.0195)		TCAGGATCCGCAGGGCTGGGA	0.592			NA											7	12					0.00198382	0.00206488	0.001984	1	0
FPR2	2358	broad.mit.edu	37	19	52272003	52272003	+	Missense_Mutation	SNP	T	T	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr19:52272003T>A	uc002pxr.2	+	2	137	c.92T>A	c.(91-93)GTG>GAG	p.V31E	FPR2_uc002pxs.3_Missense_Mutation_p.V31E|FPR2_uc010epf.2_Missense_Mutation_p.V31E	NM_001005738	NP_001005738	P25090	FPR2_HUMAN	formyl peptide receptor-like 1	31	Helical; Name=1; (Potential).				cell adhesion|cellular component movement|chemotaxis|inflammatory response	integral to membrane|plasma membrane	N-formyl peptide receptor activity			lung(3)|ovary(1)	4						CTCCCATTGGTGGTGCTTGGG	0.537			NA											15	82					0	0	0.003163	0	0
FPR2	2358	broad.mit.edu	37	19	52272902	52272902	+	Missense_Mutation	SNP	C	C	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr19:52272902C>A	uc002pxr.2	+	2	1036	c.991C>A	c.(991-993)CCA>ACA	p.P331T	FPR2_uc002pxs.3_Missense_Mutation_p.P331T|FPR2_uc010epf.2_Missense_Mutation_p.P331T	NM_001005738	NP_001005738	P25090	FPR2_HUMAN	formyl peptide receptor-like 1	331	Cytoplasmic (Potential).				cell adhesion|cellular component movement|chemotaxis|inflammatory response	integral to membrane|plasma membrane	N-formyl peptide receptor activity			lung(3)|ovary(1)	4						GGACTCAGCCCCAACTAATGA	0.537			NA											7	42					0.000157383	0.0001694	0.00308	1	0
FPR3	2359	broad.mit.edu	37	19	52327146	52327146	+	Missense_Mutation	SNP	T	T	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr19:52327146T>A	uc002pxt.1	+	2	329	c.145T>A	c.(145-147)TGG>AGG	p.W49R		NM_002030	NP_002021	P25089	FPR3_HUMAN	formyl peptide receptor-like 2	49	Helical; Name=1; (Potential).				cellular component movement|chemotaxis	integral to membrane|plasma membrane	N-formyl peptide receptor activity			lung(4)|breast(1)|skin(1)	6						GCTTGTGATCTGGGTGGCTGG	0.552			NA											40	53					0	0	0.009718	0	0
ZNF649	65251	broad.mit.edu	37	19	52394608	52394608	+	Missense_Mutation	SNP	G	G	C			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr19:52394608G>C	uc002pxy.2	-	5	1049	c.781C>G	c.(781-783)CCA>GCA	p.P261A	ZNF577_uc010ydf.1_5'Flank	NM_023074	NP_075562	Q9BS31	ZN649_HUMAN	zinc finger protein 649	261					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|central_nervous_system(1)|skin(1)	3		all_neural(266;0.0602)		GBM - Glioblastoma multiforme(134;0.00152)|OV - Ovarian serous cystadenocarcinoma(262;0.0185)		CACCCGTATGGTTTCTCTCCT	0.502			NA											18	65					0	0	0.006122	0	0
PPP2R1A	5518	broad.mit.edu	37	19	52719320	52719320	+	Missense_Mutation	SNP	G	G	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr19:52719320G>T	uc002pyp.2	+	8	1145	c.986G>T	c.(985-987)TGC>TTC	p.C329F	PPP2R1A_uc010ydk.1_Missense_Mutation_p.C274F|PPP2R1A_uc010epm.1_Missense_Mutation_p.C369F|PPP2R1A_uc002pyq.2_Missense_Mutation_p.C150F	NM_014225	NP_055040	P30153	2AAA_HUMAN	alpha isoform of regulatory subunit A, protein	329	PP2A subunit B binding.|HEAT 9.				ceramide metabolic process|chromosome segregation|G2/M transition of mitotic cell cycle|inactivation of MAPK activity|induction of apoptosis|negative regulation of cell growth|negative regulation of tyrosine phosphorylation of Stat3 protein|protein complex assembly|protein dephosphorylation|regulation of cell adhesion|regulation of cell differentiation|regulation of DNA replication|regulation of transcription, DNA-dependent|regulation of Wnt receptor signaling pathway|response to organic substance|RNA splicing|second-messenger-mediated signaling	chromosome, centromeric region|cytosol|membrane|microtubule cytoskeleton|mitochondrion|nucleus|protein phosphatase type 2A complex|soluble fraction	antigen binding|protein heterodimerization activity|protein phosphatase type 2A regulator activity			endometrium(31)|ovary(28)|lung(2)|breast(2)|skin(1)|kidney(1)|pancreas(1)	66				GBM - Glioblastoma multiforme(134;0.00456)|OV - Ovarian serous cystadenocarcinoma(262;0.015)		ATCTTGCCCTGCATCAAGGTA	0.532			NA	Mis		clear cell ovarian carcinoma								10	34					0.000673444	0.000711157	0.008291	1	0
ZNF611	81856	broad.mit.edu	37	19	53209968	53209968	+	Missense_Mutation	SNP	C	C	G			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr19:53209968C>G	uc002pzz.2	-	7	657	c.340G>C	c.(340-342)GAG>CAG	p.E114Q	ZNF611_uc010eqc.2_Missense_Mutation_p.E44Q|ZNF611_uc010ydo.1_Missense_Mutation_p.E44Q|ZNF611_uc010ydr.1_Missense_Mutation_p.E45Q|ZNF611_uc010ydp.1_Missense_Mutation_p.E114Q|ZNF611_uc010ydq.1_Missense_Mutation_p.E114Q|ZNF611_uc002qaa.3_Missense_Mutation_p.E44Q	NM_030972	NP_112234	Q8N823	ZN611_HUMAN	zinc finger protein 611 isoform a	114					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(262;0.0233)|GBM - Glioblastoma multiforme(134;0.04)		CACTGAAACTCAATGTCATGA	0.393			NA											5	176					0	0	0.001168	0	0
ZNF160	90338	broad.mit.edu	37	19	53572843	53572843	+	Missense_Mutation	SNP	C	C	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr19:53572843C>A	uc010eqk.2	-	7	1360	c.944G>T	c.(943-945)TGT>TTT	p.C315F	ZNF160_uc002qaq.3_Missense_Mutation_p.C315F|ZNF160_uc002qar.3_Missense_Mutation_p.C315F	NM_001102603	NP_001096073	Q9HCG1	ZN160_HUMAN	zinc finger protein 160	315	C2H2-type 3.				hemopoiesis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)	1				GBM - Glioblastoma multiforme(134;0.02)		ACACTCATGACATTTGTAAGG	0.413			NA											13	85					4.3838e-07	5.08003e-07	0.001855	1	0
PRKCG	5582	broad.mit.edu	37	19	54403931	54403931	+	Missense_Mutation	SNP	G	G	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr19:54403931G>T	uc002qcq.1	+	14	1785	c.1503G>T	c.(1501-1503)ATG>ATT	p.M501I	PRKCG_uc010yeg.1_Missense_Mutation_p.M501I|PRKCG_uc010yeh.1_Missense_Mutation_p.M388I	NM_002739	NP_002730	P05129	KPCG_HUMAN	protein kinase C, gamma	501	Protein kinase.				activation of phospholipase C activity|cell death|intracellular signal transduction|negative regulation of protein catabolic process|negative regulation of protein ubiquitination|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of mismatch repair|synaptic transmission	cytosol	ATP binding|protein kinase C activity|zinc ion binding			lung(4)|ovary(2)|pancreas(2)|large_intestine(1)	9	all_cancers(19;0.0462)|all_epithelial(19;0.0258)|all_lung(19;0.185)|Ovarian(34;0.19)|Lung NSC(19;0.218)			GBM - Glioblastoma multiforme(134;0.0521)		ACTTTGGCATGTGTAAGGAGA	0.587			NA											124	255					1.03055e-72	1.45419e-72	0.01441	1	0
LENG8	114823	broad.mit.edu	37	19	54967885	54967885	+	Missense_Mutation	SNP	G	G	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr19:54967885G>A	uc002qfv.1	+	10	1549	c.1405G>A	c.(1405-1407)GAG>AAG	p.E469K	LENG8_uc002qfw.2_Missense_Mutation_p.E506K			Q96PV6	LENG8_HUMAN	RecName: Full=Leukocyte receptor cluster member 8;	469							protein binding			central_nervous_system(1)|pancreas(1)	2	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.139)		CCCGGAGCGAGAGCTGAAGAA	0.667			NA											5	23					0	0	0.001168	0	0
C19orf51	352909	broad.mit.edu	37	19	55670723	55670723	+	Missense_Mutation	SNP	C	C	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr19:55670723C>A	uc002qji.1	-	12	1367	c.1333G>T	c.(1333-1335)GCC>TCC	p.A445S	TNNI3_uc002qjg.3_5'Flank|TNNI3_uc010yft.1_5'Flank|C19orf51_uc002qjh.1_Missense_Mutation_p.A260S|C19orf51_uc002qjj.1_Missense_Mutation_p.A492S|C19orf51_uc002qjk.1_Missense_Mutation_p.A391S|C19orf51_uc002qjl.1_Missense_Mutation_p.A512S			Q8N9W5	CS051_HUMAN	RecName: Full=UPF0470 protein C19orf51;	445											0			BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.044)		GAAGGCCTGGCCCCGGTCTGT	0.617			NA											10	91					4.68919e-08	5.56267e-08	0.008291	1	0
ZNF628	89887	broad.mit.edu	37	19	55993190	55993190	+	Silent	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr19:55993190C>T	uc002qld.2	+	3	1183	c.618C>T	c.(616-618)CCC>CCT	p.P206P		NM_033113	NP_149104	Q5EBL2	ZN628_HUMAN	zinc finger protein 628	206	C2H2-type 7.					nucleus	DNA binding|zinc ion binding				0	Breast(117;0.155)		BRCA - Breast invasive adenocarcinoma(297;0.18)|LUSC - Lung squamous cell carcinoma(43;0.193)	GBM - Glioblastoma multiforme(193;0.0531)		CGCTCTGCCCCAAGACCTTCA	0.522			NA											5	7					0	0	0.000602	0	0
NLRP4	147945	broad.mit.edu	37	19	56382250	56382250	+	Silent	SNP	G	G	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr19:56382250G>A	uc002qmd.3	+	7	2834	c.2412G>A	c.(2410-2412)CTG>CTA	p.L804L	NLRP4_uc002qmf.2_Silent_p.L729L|NLRP4_uc010etf.2_Silent_p.L579L	NM_134444	NP_604393	Q96MN2	NALP4_HUMAN	NLR family, pyrin domain containing 4	804							ATP binding			ovary(5)|skin(4)|lung(3)|upper_aerodigestive_tract(1)|kidney(1)|pancreas(1)	15		Colorectal(82;0.0002)|Ovarian(87;0.221)		GBM - Glioblastoma multiforme(193;0.0606)		AAATGCTTCTGCGTAACAAGA	0.527			NA											16	54					0	0	0.004007	0	0
NLRP5	126206	broad.mit.edu	37	19	56544115	56544115	+	Silent	SNP	G	G	C			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr19:56544115G>C	uc002qmj.2	+	8	2415	c.2415G>C	c.(2413-2415)CTG>CTC	p.L805L	NLRP5_uc002qmi.2_Silent_p.L786L	NM_153447	NP_703148	P59047	NALP5_HUMAN	NACHT, LRR and PYD containing protein 5	805						mitochondrion|nucleolus	ATP binding			ovary(3)|skin(2)|kidney(1)|central_nervous_system(1)	7		Colorectal(82;3.46e-05)|Ovarian(87;0.0481)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0326)		GTGCCAAGCTGAGGCATCCCA	0.607			NA											21	106					0	0	0.012319	0	0
ZIM3	114026	broad.mit.edu	37	19	57649865	57649865	+	Missense_Mutation	SNP	C	C	G			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr19:57649865C>G	uc002qnz.1	-	3	503	c.117G>C	c.(115-117)GAG>GAC	p.E39D		NM_052882	NP_443114	Q96PE6	ZIM3_HUMAN	zinc finger, imprinted 3	39	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			pancreas(1)|skin(1)	2		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.243)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		TGCTGTAATTCTCCAGCATCA	0.547			NA											17	72					0	0	0.004007	0	0
AURKC	6795	broad.mit.edu	37	19	57744834	57744834	+	Nonsense_Mutation	SNP	G	G	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr19:57744834G>T	uc002qoe.2	+	5	631	c.442G>T	c.(442-444)GAG>TAG	p.E148*	AURKC_uc002qoc.2_Nonsense_Mutation_p.E129*|AURKC_uc002qod.2_Nonsense_Mutation_p.E114*|AURKC_uc010etv.2_Nonsense_Mutation_p.E145*	NM_001015878	NP_001015878	Q9UQB9	AURKC_HUMAN	aurora kinase C isoform 1	148	Protein kinase.		E -> Q (in a lung squamous cell carcinoma sample; somatic mutation).		cell cycle|cytokinesis	condensed chromosome|cytoplasm|midbody|spindle midzone	ATP binding|protein serine/threonine kinase activity	p.E114Q(1)		lung(4)|ovary(2)	6		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0122)		ACAGATAATAGAGGAGTTGGC	0.478			NA											17	76					1.15088e-07	1.34873e-07	0.004007	1	0
ZNF548	147694	broad.mit.edu	37	19	57910783	57910783	+	Nonsense_Mutation	SNP	C	C	G			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr19:57910783C>G	uc002qom.2	+	3	1378	c.1128C>G	c.(1126-1128)TAC>TAG	p.Y376*	ZNF547_uc002qpm.3_Intron|ZNF548_uc002qon.2_Nonsense_Mutation_p.Y379*	NM_152909	NP_690873	Q8NEK5	ZN548_HUMAN	zinc finger protein 548	376	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)	1		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.221)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		TGTTTAGGTACAACTCCAGCC	0.403			NA											4	19					0	0	0.009096	0	0
ZNF416	55659	broad.mit.edu	37	19	58087249	58087249	+	Missense_Mutation	SNP	C	C	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr19:58087249C>A	uc002qpf.2	-	3	296	c.125G>T	c.(124-126)TGG>TTG	p.W42L	ZNF547_uc002qpm.3_Intron	NM_017879	NP_060349	Q9BWM5	ZN416_HUMAN	zinc finger protein 416	42	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0259)		AAGGAGCCCCCATTCTTCCTG	0.537			NA											42	78					2.19962e-31	3.07397e-31	0.00874	1	0
ZSCAN18	65982	broad.mit.edu	37	19	58598331	58598331	+	Missense_Mutation	SNP	C	C	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr19:58598331C>A	uc002qri.2	-	5	996	c.687G>T	c.(685-687)TGG>TGT	p.W229C	ZSCAN18_uc002qrj.3_Missense_Mutation_p.W229C|ZSCAN18_uc010yhs.1_Missense_Mutation_p.W94C|ZSCAN18_uc002qrh.2_Missense_Mutation_p.W229C|ZSCAN18_uc010yht.1_Missense_Mutation_p.W285C|ZSCAN18_uc002qrk.1_3'UTR|ZSCAN18_uc002qrl.2_3'UTR	NM_001145543	NP_001139015	Q8TBC5	ZSC18_HUMAN	zinc finger and SCAN domain containing 18	229					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Colorectal(82;0.000256)|all_neural(62;0.0412)|Breast(46;0.114)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0152)		CCAGGTGGCCCCACTCCCCCA	0.637			NA											17	57					2.35188e-11	2.94391e-11	0.006122	1	0
TMEM18	129787	broad.mit.edu	37	2	669766	669766	+	Missense_Mutation	SNP	C	C	G			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr2:669766C>G	uc002qwl.2	-	4	412	c.318G>C	c.(316-318)ATG>ATC	p.M106I	TMEM18_uc002qwk.2_RNA	NM_152834	NP_690047	Q96B42	TMM18_HUMAN	transmembrane protein 18	106	Helical; (Potential).				cell migration	integral to membrane|nuclear membrane				ovary(1)	1	all_hematologic(175;0.0429)|Acute lymphoblastic leukemia(172;0.0627)	all_cancers(51;5.27e-05)|all_epithelial(98;2.11e-06)|Ovarian(717;0.0253)		all cancers(51;1.95e-21)|Epithelial(75;9.47e-21)|OV - Ovarian serous cystadenocarcinoma(76;8.15e-18)|GBM - Glioblastoma multiforme(21;0.0285)		CCACAATGATCATGGCATTCA	0.358			NA											14	26					0	0	0.00245	0	0
TPO	7173	broad.mit.edu	37	2	1418261	1418261	+	Silent	SNP	A	A	G			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr2:1418261A>G	uc002qww.2	+	2	172	c.81A>G	c.(79-81)AAA>AAG	p.K27K	TPO_uc010ewj.2_Intron|TPO_uc010yin.1_Silent_p.K27K|TPO_uc002qwu.2_Silent_p.K27K|TPO_uc002qwr.2_Silent_p.K27K|TPO_uc002qwx.2_Silent_p.K27K|TPO_uc010yio.1_Silent_p.K27K|TPO_uc010yip.1_Silent_p.K27K	NM_000547	NP_000538	P07202	PERT_HUMAN	thyroid peroxidase isoform a	27	Extracellular (Potential).				cellular nitrogen compound metabolic process|hormone biosynthetic process|hydrogen peroxide catabolic process	cell surface|cytoplasm|integral to plasma membrane	calcium ion binding|heme binding|iodide peroxidase activity			ovary(7)|pancreas(6)|skin(5)|lung(1)|kidney(1)	20	all_hematologic(175;0.0487)|Acute lymphoblastic leukemia(172;0.0627)	all_cancers(51;0.0338)		all cancers(51;0.0356)|OV - Ovarian serous cystadenocarcinoma(76;0.0748)|Epithelial(75;0.12)	Carbimazole(DB00389)|Methimazole(DB00763)|Propylthiouracil(DB00550)	CGAGAGGGAAAGAACTCCTTT	0.458			NA											16	16					0	0	0.008871	0	0
PXDN	7837	broad.mit.edu	37	2	1639197	1639197	+	Missense_Mutation	SNP	T	T	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr2:1639197T>A	uc002qxa.2	-	22	4367	c.4303A>T	c.(4303-4305)ACC>TCC	p.T1435S		NM_012293	NP_036425	Q92626	PXDN_HUMAN	peroxidasin precursor	1435	VWFC.				extracellular matrix organization|hydrogen peroxide catabolic process|immune response	endoplasmic reticulum|extracellular space|proteinaceous extracellular matrix	extracellular matrix structural constituent|heme binding|interleukin-1 receptor antagonist activity|peroxidase activity			pancreas(6)|ovary(2)	8	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.0845)|Lung NSC(108;0.00641)|all_epithelial(98;0.00716)		all cancers(51;0.0492)|OV - Ovarian serous cystadenocarcinoma(76;0.0973)|Epithelial(75;0.17)|GBM - Glioblastoma multiforme(21;0.228)		TCACAAATGGTGCATGCATCT	0.512			NA											5	4					0	0	0.001984	0	0
COLEC11	78989	broad.mit.edu	37	2	3685153	3685153	+	Missense_Mutation	SNP	G	G	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr2:3685153G>T	uc002qya.2	+	4	381	c.233G>T	c.(232-234)AGT>ATT	p.S78I	COLEC11_uc002qxz.2_Missense_Mutation_p.S75I|COLEC11_uc002qyb.2_Missense_Mutation_p.S54I|COLEC11_uc002qyc.2_Intron|COLEC11_uc010ewo.2_Intron|COLEC11_uc010ewp.2_Missense_Mutation_p.S52I|COLEC11_uc010ewq.2_Missense_Mutation_p.S28I|COLEC11_uc010ewr.2_Intron|COLEC11_uc010ews.2_Intron	NM_024027	NP_076932	Q9BWP8	COL11_HUMAN	collectin sub-family member 11 isoform a	78	Collagen-like.					collagen	mannose binding				0	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.093)			OV - Ovarian serous cystadenocarcinoma(76;0.127)		CAGAAAGGCAGTGTGGGTCGT	0.512			NA											20	27					1.96292e-10	2.40927e-10	0.010504	1	0
ALLC	55821	broad.mit.edu	37	2	3726108	3726108	+	Nonsense_Mutation	SNP	G	G	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr2:3726108G>A	uc010ewt.2	+	4	296	c.135G>A	c.(133-135)TGG>TGA	p.W45*		NM_018436	NP_060906	Q8N6M5	ALLC_HUMAN	allantoicase isoform a	64							allantoicase activity			central_nervous_system(1)	1	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.088)	all_cancers(51;0.24)		OV - Ovarian serous cystadenocarcinoma(76;0.088)|all cancers(51;0.151)|Epithelial(75;0.206)		TTGGGAAATGGATGGATGGCT	0.463			NA								HNSCC(21;0.051)			15	9					0	0	0.003163	0	0
CMPK2	129607	broad.mit.edu	37	2	7001425	7001425	+	Missense_Mutation	SNP	G	G	C			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr2:7001425G>C	uc002qyo.2	-	3	991	c.882C>G	c.(880-882)ATC>ATG	p.I294M	CMPK2_uc010yis.1_Missense_Mutation_p.I294M|CMPK2_uc010ewv.2_Missense_Mutation_p.I294M	NM_207315	NP_997198	Q5EBM0	CMPK2_HUMAN	UMP-CMP kinase 2 precursor	294					dTDP biosynthetic process	mitochondrion	ATP binding|cytidylate kinase activity|thymidylate kinase activity|UMP kinase activity				0	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)					CATCATCAAAGATCTTCCTCC	0.448			NA											7	32					0	0	0.001984	0	0
KIDINS220	57498	broad.mit.edu	37	2	8888088	8888088	+	Missense_Mutation	SNP	C	C	G			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr2:8888088C>G	uc002qzc.2	-	25	3639	c.3457G>C	c.(3457-3459)GGC>CGC	p.G1153R	KIDINS220_uc010yiv.1_Intron|KIDINS220_uc002qzd.2_Intron|KIDINS220_uc010yiw.1_Intron|KIDINS220_uc002qzb.2_Missense_Mutation_p.G26R|KIDINS220_uc002qze.2_3'UTR	NM_020738	NP_065789	Q9ULH0	KDIS_HUMAN	kinase D-interacting substrate of 220 kDa	1153	Cytoplasmic (Potential).				activation of MAPKK activity|nerve growth factor receptor signaling pathway	cytosol|integral to membrane				ovary(3)|central_nervous_system(1)	4	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)					TGGGAGCCGCCAGGGTAATAC	0.403			NA											7	9					0	0	0.004482	0	0
ADAM17	6868	broad.mit.edu	37	2	9633917	9633917	+	Missense_Mutation	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr2:9633917C>T	uc002qzu.2	-	16	2135	c.1952G>A	c.(1951-1953)CGA>CAA	p.R651Q	IAH1_uc010yiz.1_Intron|ADAM17_uc010ewy.2_Missense_Mutation_p.R651Q|ADAM17_uc010ewz.2_Intron	NM_003183	NP_003174	P78536	ADA17_HUMAN	a disintegrin and metalloprotease domain 17	651	Crambin-like.|Extracellular (Potential).				B cell differentiation|cell adhesion mediated by integrin|epidermal growth factor receptor signaling pathway|epidermal growth factor receptor transactivation by G-protein coupled receptor signaling pathway|germinal center formation|membrane protein intracellular domain proteolysis|negative regulation of interleukin-8 production|nerve growth factor receptor signaling pathway|Notch signaling pathway|PMA-inducible membrane protein ectodomain proteolysis|positive regulation of cell growth|positive regulation of cell proliferation|positive regulation of chemokine production|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of protein phosphorylation|positive regulation of T cell chemotaxis|positive regulation of transforming growth factor beta receptor signaling pathway|regulation of mast cell apoptosis|response to drug|response to high density lipoprotein particle stimulus|response to hypoxia|response to lipopolysaccharide|spleen development|T cell differentiation in thymus|wound healing, spreading of epidermal cells	actin cytoskeleton|apical plasma membrane|cell surface|cytoplasm|integral to plasma membrane|membrane raft	integrin binding|interleukin-6 receptor binding|metalloendopeptidase activity|PDZ domain binding|SH3 domain binding|zinc ion binding			lung(1)|kidney(1)	2	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.225)		ATCCCAAAATCGTTCAATTAC	0.378			NA											3	21					0	0	0.004672	0	0
KCNS3	3790	broad.mit.edu	37	2	18112823	18112823	+	Missense_Mutation	SNP	C	C	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr2:18112823C>A	uc002rcv.2	+	3	999	c.548C>A	c.(547-549)TCC>TAC	p.S183Y	KCNS3_uc002rcw.2_Missense_Mutation_p.S183Y	NM_002252	NP_002243	Q9BQ31	KCNS3_HUMAN	potassium voltage-gated channel	183	Cytoplasmic (Potential).				energy reserve metabolic process|regulation of insulin secretion	Golgi apparatus|voltage-gated potassium channel complex	delayed rectifier potassium channel activity|potassium channel regulator activity			ovary(4)	4	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.158)					TACTGCCTGTCCGCTAAGCTT	0.507			NA											14	30					9.31168e-06	1.04004e-05	0.001855	1	0
SDC1	6382	broad.mit.edu	37	2	20404000	20404000	+	Silent	SNP	G	G	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr2:20404000G>A	uc002rdo.1	-	3	500	c.201C>T	c.(199-201)GAC>GAT	p.D67D	SDC1_uc002rdp.1_Silent_p.D67D|SDC1_uc010exv.2_Silent_p.D67D|SDC1_uc010exw.1_RNA	NM_002997	NP_002988	P18827	SDC1_HUMAN	syndecan 1 precursor	67	Extracellular (Potential).				lipid metabolic process|lipoprotein metabolic process|myoblast development|striated muscle cell development	cytoplasm|extracellular region|focal adhesion|integral to plasma membrane	cytoskeletal protein binding|protein C-terminus binding			ovary(4)|skin(1)	5	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)			OV - Ovarian serous cystadenocarcinoma(76;0.221)		GGAGCTGCGTGTCCTTCCAAG	0.637			NA											97	69					0	0	0.01441	0	0
APOB	338	broad.mit.edu	37	2	21234952	21234952	+	Silent	SNP	T	T	C			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr2:21234952T>C	uc002red.2	-	26	4916	c.4788A>G	c.(4786-4788)GCA>GCG	p.A1596A		NM_000384	NP_000375	P04114	APOB_HUMAN	apolipoprotein B precursor	1596					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			ovary(11)|skin(9)|central_nervous_system(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	AACGCAGCAGTGCATTTTGCT	0.408			NA											21	22					0	0	0.008871	0	0
APOB	338	broad.mit.edu	37	2	21235014	21235014	+	Missense_Mutation	SNP	C	C	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr2:21235014C>A	uc002red.2	-	26	4854	c.4726G>T	c.(4726-4728)GGG>TGG	p.G1576W		NM_000384	NP_000375	P04114	APOB_HUMAN	apolipoprotein B precursor	1576					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			ovary(11)|skin(9)|central_nervous_system(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	TTATACTTCCCATTGGTGTCA	0.413			NA											23	34					3.85864e-22	5.26574e-22	0.00278	1	0
NCOA1	8648	broad.mit.edu	37	2	24920559	24920559	+	Missense_Mutation	SNP	A	A	G			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr2:24920559A>G	uc002rfk.2	+	9	1099	c.841A>G	c.(841-843)AGA>GGA	p.R281G	NCOA1_uc010eye.2_Missense_Mutation_p.R281G|NCOA1_uc002rfi.2_Missense_Mutation_p.R130G|NCOA1_uc002rfj.2_Missense_Mutation_p.R281G|NCOA1_uc002rfl.2_Missense_Mutation_p.R281G	NM_003743	NP_003734	Q15788	NCOA1_HUMAN	nuclear receptor coactivator 1 isoform 1	281									PAX3/NCOA1(8)	soft_tissue(8)|ovary(1)|lung(1)|skin(1)	11	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TAGTTCCCTGAGAGCTGCTGG	0.368			NA	T	PAX3	alveolar rhadomyosarcoma								8	15					0	0	0.00308	0	0
GPR113	165082	broad.mit.edu	37	2	26533740	26533740	+	Silent	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr2:26533740C>T	uc002rhe.3	-	11	2856	c.2856G>A	c.(2854-2856)CTG>CTA	p.L952L	GPR113_uc010yky.1_Silent_p.L883L|GPR113_uc002rhb.1_Silent_p.L555L|GPR113_uc010eyk.1_Silent_p.L753L|GPR113_uc002rhc.1_Silent_p.L555L|GPR113_uc002rhd.1_RNA	NM_001145168	NP_001138640	Q8IZF5	GP113_HUMAN	G-protein coupled receptor 113 isoform 1	952	Cytoplasmic (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(4)	4	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GCGAAGGTCTCAGCAACTTCA	0.582			NA											11	17					0	0	0.008291	0	0
ZNF513	130557	broad.mit.edu	37	2	27603003	27603003	+	Missense_Mutation	SNP	G	G	C	rs144091327	byFrequency	TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr2:27603003G>C	uc002rkk.2	-	2	368	c.168C>G	c.(166-168)GAC>GAG	p.D56E	ZNF513_uc002rkj.2_5'UTR	NM_144631	NP_653232	Q8N8E2	ZN513_HUMAN	zinc finger protein 513	56	Gly-rich.				regulation of transcription, DNA-dependent|response to stimulus|retina development in camera-type eye|transcription, DNA-dependent|visual perception	nucleus	transcription regulatory region DNA binding|zinc ion binding			ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CACTGTTGCCGTCGCCTTCCT	0.582			NA											30	159					0	0	0.010818	0	0
IFT172	26160	broad.mit.edu	37	2	27706212	27706212	+	Missense_Mutation	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr2:27706212C>T	uc002rku.2	-	7	565	c.514G>A	c.(514-516)GCA>ACA	p.A172T	IFT172_uc002rkw.2_Missense_Mutation_p.A172T|IFT172_uc010yls.1_Missense_Mutation_p.A151T|IFT172_uc010ezc.2_Missense_Mutation_p.A172T|IFT172_uc002rkv.2_Missense_Mutation_p.A172T	NM_015662	NP_056477	Q9UG01	IF172_HUMAN	selective LIM binding factor homolog	172	WD 4.				cilium assembly	cilium	binding			large_intestine(1)|ovary(1)	2	Acute lymphoblastic leukemia(172;0.155)					GTACCATCTGCATGACCAGAG	0.383			NA											7	64					0	0	0.004482	0	0
C2orf16	84226	broad.mit.edu	37	2	27800472	27800472	+	Missense_Mutation	SNP	G	G	C			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr2:27800472G>C	uc002rkz.3	+	1	1084	c.1033G>C	c.(1033-1035)GAT>CAT	p.D345H		NM_032266	NP_115642	Q68DN1	CB016_HUMAN	hypothetical protein LOC84226	345										large_intestine(1)	1	Acute lymphoblastic leukemia(172;0.155)					TCACGTCCCAGATTCTGCTTC	0.443			NA											7	33					0	0	0.00308	0	0
C2orf16	84226	broad.mit.edu	37	2	27800886	27800886	+	Missense_Mutation	SNP	G	G	C			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr2:27800886G>C	uc002rkz.3	+	1	1498	c.1447G>C	c.(1447-1449)GAT>CAT	p.D483H		NM_032266	NP_115642	Q68DN1	CB016_HUMAN	hypothetical protein LOC84226	483										large_intestine(1)	1	Acute lymphoblastic leukemia(172;0.155)					AGAGCCACTAGATCAAGTCAC	0.423			NA											7	45					0	0	0.001984	0	0
XDH	7498	broad.mit.edu	37	2	31595220	31595220	+	Missense_Mutation	SNP	G	G	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr2:31595220G>A	uc002rnv.1	-	17	1809	c.1730C>T	c.(1729-1731)CCC>CTC	p.P577L		NM_000379	NP_000370	P47989	XDH_HUMAN	xanthine dehydrogenase	577					purine nucleotide catabolic process|xanthine catabolic process	cytosol|extracellular region|peroxisome	2 iron, 2 sulfur cluster binding|electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|molybdopterin cofactor binding|protein homodimerization activity|xanthine dehydrogenase activity|xanthine oxidase activity			skin(4)|breast(2)|ovary(1)|central_nervous_system(1)	8	Acute lymphoblastic leukemia(172;0.155)				Allopurinol(DB00437)|Carvedilol(DB01136)|Daunorubicin(DB00694)|Deferoxamine(DB00746)|Desflurane(DB01189)|Menadione(DB00170)|Mercaptopurine(DB01033)|Methotrexate(DB00563)|NADH(DB00157)|Nitrofurazone(DB00336)|Papaverine(DB01113)|Procarbazine(DB01168)|Pyrazinamide(DB00339)|Rasburicase(DB00049)|Spermine(DB00127)|Trifluoperazine(DB00831)|Vitamin E(DB00163)	GTGGGGCAGGGGCCGGCCCAC	0.622	Colon(66;682 1445 30109 40147)		NA											41	193					0	0	0.009718	0	0
LTBP1	4052	broad.mit.edu	37	2	33172863	33172863	+	Missense_Mutation	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr2:33172863C>T	uc002ros.2	+	1	472	c.472C>T	c.(472-474)CAC>TAC	p.H158Y		NM_206943	NP_996826	Q14766	LTBP1_HUMAN	latent transforming growth factor beta binding	158					negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta	proteinaceous extracellular matrix	calcium ion binding|growth factor binding|transforming growth factor beta receptor activity			ovary(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|central_nervous_system(1)	8	all_hematologic(175;0.115)	Medulloblastoma(90;0.215)				GCTGCAGGTTCACCAGAAGCA	0.512			NA											8	9					0	0	0.00308	0	0
C2orf56	55471	broad.mit.edu	37	2	37464981	37464981	+	Missense_Mutation	SNP	A	A	G			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr2:37464981A>G	uc002rqa.3	+	4	454	c.379A>G	c.(379-381)AGG>GGG	p.R127G	C2orf56_uc010ynj.1_Intron|C2orf56_uc002rqc.3_Missense_Mutation_p.R100G|C2orf56_uc010ynk.1_Missense_Mutation_p.R127G|C2orf56_uc010ynl.1_Missense_Mutation_p.R100G	NM_144736	NP_653337	Q7L592	MIDA_HUMAN	hypothetical protein LOC55471 isoform 1	127					mitochondrial respiratory chain complex I assembly	mitochondrion	enzyme binding|methyltransferase activity			central_nervous_system(1)	1		all_hematologic(82;0.21)				GGGCCCAGGTAGGGGAACCCT	0.423			NA											5	21					0	0	0.000602	0	0
HNRPLL	92906	broad.mit.edu	37	2	38796436	38796436	+	Nonsense_Mutation	SNP	C	C	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr2:38796436C>A	uc002rqw.2	-	10	1665	c.1255G>T	c.(1255-1257)GAG>TAG	p.E419*	HNRPLL_uc002rqv.2_Nonsense_Mutation_p.E114*|HNRPLL_uc002rqx.2_Nonsense_Mutation_p.E414*	NM_138394	NP_612403	Q8WVV9	HNRLL_HUMAN	heterogeneous nuclear ribonucleoprotein L-like	419					mRNA processing|positive regulation of RNA splicing	nucleus|ribonucleoprotein complex	mRNA binding|nucleotide binding|protein binding			skin(1)	1		all_hematologic(82;0.248)				TCCTCCAGCTCAAATATTTGA	0.368			NA											9	18					2.74318e-10	3.3641e-10	0.006214	1	0
DHX57	90957	broad.mit.edu	37	2	39088536	39088536	+	Missense_Mutation	SNP	T	T	G			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr2:39088536T>G	uc002rrf.2	-	5	1115	c.1016A>C	c.(1015-1017)GAT>GCT	p.D339A	DHX57_uc002rre.2_5'UTR|DHX57_uc002rrg.2_Missense_Mutation_p.D339A	NM_198963	NP_945314	Q6P158	DHX57_HUMAN	DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57	339							ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding|zinc ion binding			ovary(1)|lung(1)|skin(1)	3		all_hematologic(82;0.248)				ATGAGAATCATCTACACTTCT	0.333	Melanoma(191;1090 2095 4375 23729 47341)		NA											11	14					0	0	0.008291	0	0
SOS1	6654	broad.mit.edu	37	2	39278356	39278356	+	Missense_Mutation	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr2:39278356C>T	uc002rrk.3	-	6	834	c.793G>A	c.(793-795)GAT>AAT	p.D265N	SOS1_uc010ynr.1_RNA|SOS1_uc002rrl.2_5'UTR	NM_005633	NP_005624	Q07889	SOS1_HUMAN	son of sevenless homolog 1	265	DH.				apoptosis|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|induction of apoptosis by extracellular signals|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	cytosol	DNA binding|protein binding|Rho GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			ovary(4)|breast(3)|lung(2)|central_nervous_system(1)	10		all_hematologic(82;0.21)				TCTACTGTATCTTCTATATGG	0.373			NA							Noonan_syndrome				6	33					0	0	0.001168	0	0
EML4	27436	broad.mit.edu	37	2	42511835	42511835	+	Missense_Mutation	SNP	G	G	C			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr2:42511835G>C	uc002rsi.2	+	9	1265	c.1003G>C	c.(1003-1005)GAT>CAT	p.D335H	EML4_uc010fap.2_Missense_Mutation_p.D277H|EML4_uc002rsj.2_5'Flank	NM_019063	NP_061936	Q9HC35	EMAL4_HUMAN	echinoderm microtubule associated protein like 4	335	WD 1.				microtubule-based process|mitosis	cytoplasm|microtubule	protein binding		EML4/ALK(246)	lung(246)|ovary(2)|central_nervous_system(1)|skin(1)	250						CGTGGATAAAGATGGAAGGGT	0.368			NA	T	ALK	NSCLC								7	27					0	0	0.00308	0	0
SLC3A1	6519	broad.mit.edu	37	2	44503035	44503035	+	Missense_Mutation	SNP	G	G	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr2:44503035G>T	uc002ruc.3	+	1	439	c.361G>T	c.(361-363)GGG>TGG	p.G121W	SLC3A1_uc002rty.2_Missense_Mutation_p.G121W|SLC3A1_uc002rtz.2_Missense_Mutation_p.G121W|SLC3A1_uc002rua.2_Missense_Mutation_p.G121W|SLC3A1_uc002rub.2_Missense_Mutation_p.G121W	NM_000341	NP_000332	Q07837	SLC31_HUMAN	solute carrier family 3, member 1	121	Extracellular (Potential).				carbohydrate metabolic process|cellular amino acid metabolic process|ion transport	integral to plasma membrane|membrane fraction	basic amino acid transmembrane transporter activity|catalytic activity|cation binding|L-cystine transmembrane transporter activity				0		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)			L-Cystine(DB00138)	GTGGCAGGAGGGGCCCATGTA	0.542			NA											48	60					4.10826e-27	5.67573e-27	0.01441	1	0
BCL11A	53335	broad.mit.edu	37	2	60688050	60688050	+	Missense_Mutation	SNP	G	G	C			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr2:60688050G>C	uc002sae.1	-	4	2225	c.1997C>G	c.(1996-1998)TCC>TGC	p.S666C	BCL11A_uc002sab.2_Missense_Mutation_p.S666C|BCL11A_uc002sac.2_Intron|BCL11A_uc010ypi.1_Missense_Mutation_p.S335C|BCL11A_uc010ypj.1_Missense_Mutation_p.S632C|BCL11A_uc002sad.1_Missense_Mutation_p.S514C|BCL11A_uc002saf.1_Missense_Mutation_p.S632C	NM_022893	NP_075044	Q9H165	BC11A_HUMAN	B-cell CLL/lymphoma 11A isoform 1	666					negative regulation of axon extension|negative regulation of collateral sprouting|negative regulation of dendrite development|positive regulation of collateral sprouting|positive regulation of neuron projection development|positive regulation of transcription from RNA polymerase II promoter|protein sumoylation|regulation of dendrite development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|cytoplasm|nucleus|nucleus	nucleic acid binding|protein heterodimerization activity|protein homodimerization activity|zinc ion binding			central_nervous_system(6)|breast(3)|ovary(2)|skin(2)	13			LUSC - Lung squamous cell carcinoma(5;9.29e-08)|Lung(5;1.34e-06)|Epithelial(17;0.0562)|all cancers(80;0.199)			GAGCTGCCTGGAGGCCGCGTA	0.612			NA	T	IGH@	B-CLL								19	34					0	0	0.006122	0	0
CLEC4F	165530	broad.mit.edu	37	2	71039605	71039605	+	Missense_Mutation	SNP	C	C	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr2:71039605C>A	uc002shf.2	-	5	1590	c.1513G>T	c.(1513-1515)GCA>TCA	p.A505S	CLEC4F_uc010yqv.1_Missense_Mutation_p.A505S	NM_173535	NP_775806	Q8N1N0	CLC4F_HUMAN	C-type lectin, superfamily member 13	505	Extracellular (Potential).|C-type lectin.				endocytosis	integral to membrane	receptor activity|sugar binding			ovary(5)	5						GCCACAGATGCCAGATGGGCT	0.512	Colon(107;10 2157 6841 26035)		NA											45	40					1.56793e-16	2.07721e-16	0.01441	1	0
INO80B	83444	broad.mit.edu	37	2	74682559	74682559	+	Missense_Mutation	SNP	G	G	T	rs115610738	by1000genomes	TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr2:74682559G>T	uc002slg.2	+	2	130	c.85G>T	c.(85-87)GGT>TGT	p.G29C	INO80B_uc002slf.1_Missense_Mutation_p.G16C|INO80B_uc010yrr.1_Missense_Mutation_p.G16C|WBP1_uc002slh.1_RNA|INO80B_uc002sli.1_RNA|INO80B_uc010yrs.1_Missense_Mutation_p.G47C	NM_031288	NP_112578	Q9C086	IN80B_HUMAN	high mobility group AT-hook 1-like 4	29					DNA recombination|DNA repair|regulation of transcription, DNA-dependent|transcription, DNA-dependent	Ino80 complex|nucleolus	metal ion binding|protein binding			pancreas(1)	1						GAGCCTGGCGGGTGCCCATGG	0.478			NA											16	69					2.31682e-05	2.54658e-05	0.003163	1	0
HK2	3099	broad.mit.edu	37	2	75107651	75107651	+	Missense_Mutation	SNP	G	G	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr2:75107651G>A	uc002snd.2	+	10	3451	c.1525G>A	c.(1525-1527)GTC>ATC	p.V509I		NM_000189	NP_000180	P52789	HXK2_HUMAN	hexokinase 2	509	Catalytic.				apoptotic mitochondrial changes|glucose transport|glycolysis|transmembrane transport	cytosol|mitochondrial outer membrane	ATP binding|glucokinase activity			ovary(1)|lung(1)	2						CAGTGCCCCCGTCAAGATGCT	0.597			NA											16	37					0	0	0.004007	0	0
THNSL2	55258	broad.mit.edu	37	2	88482504	88482504	+	Missense_Mutation	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr2:88482504C>T	uc002ssz.3	+	7	1142	c.989C>T	c.(988-990)TCT>TTT	p.S330F	THNSL2_uc002ssv.2_RNA|THNSL2_uc002ssw.3_Missense_Mutation_p.S330F|THNSL2_uc002ssx.3_Intron|THNSL2_uc002sta.3_Missense_Mutation_p.S172F|THNSL2_uc002ssy.3_Missense_Mutation_p.S330F|THNSL2_uc010fhe.2_Missense_Mutation_p.S172F	NM_018271	NP_060741	Q86YJ6	THNS2_HUMAN	threonine synthase-like 2	330					threonine biosynthetic process		threonine synthase activity			ovary(1)	1						TGGCTGCTCTCTGGCTCTGAC	0.547			NA											7	24					0	0	0.00308	0	0
RPIA	22934	broad.mit.edu	37	2	89035252	89035252	+	Missense_Mutation	SNP	C	C	G			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr2:89035252C>G	uc002ste.2	+	6	635	c.594C>G	c.(592-594)TTC>TTG	p.F198L		NM_144563	NP_653164	P49247	RPIA_HUMAN	ribose 5-phosphate isomerase A	198					pentose-phosphate shunt, non-oxidative branch	cytosol	ribose-5-phosphate isomerase activity			ovary(1)	1		Acute lymphoblastic leukemia(2;0.000456)|all_hematologic(2;0.00287)				TCGCTGATTTCAGGTACAGTT	0.517			NA											60	114					0	0	0.01441	0	0
MRPS5	64969	broad.mit.edu	37	2	95756262	95756262	+	Missense_Mutation	SNP	C	C	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr2:95756262C>A	uc002sub.2	-	11	1155	c.937G>T	c.(937-939)GGC>TGC	p.G313C	MRPS5_uc002suc.2_RNA	NM_031902	NP_114108	P82675	RT05_HUMAN	mitochondrial ribosomal protein S5	313					translation	mitochondrion|ribosome	protein binding|RNA binding|structural constituent of ribosome			ovary(2)|central_nervous_system(1)	3						CAGCGGAGGCCGTAACCTAGA	0.522			NA											29	91					1.50538e-07	1.76275e-07	0.00632	1	0
FER1L5	90342	broad.mit.edu	37	2	97368993	97368993	+	Silent	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr2:97368993C>T	uc010fia.2	+	49	5709	c.5709C>T	c.(5707-5709)ATC>ATT	p.I1903I	FER1L5_uc002sws.3_Silent_p.I612I|FER1L5_uc002swt.3_Silent_p.I612I|FER1L5_uc010yus.1_Silent_p.I611I	NM_001113382	NP_001106853	A0AVI2	FR1L5_HUMAN	fer-1-like 5 isoform 2	1903						integral to membrane				ovary(1)	1						CCTATTTCATCCAATACAAGC	0.572			NA											52	127					0	0	0.01441	0	0
EIF5B	9669	broad.mit.edu	37	2	99985017	99985017	+	Missense_Mutation	SNP	G	G	C	rs3205291		TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr2:99985017G>C	uc002tab.2	+	7	1534	c.1350G>C	c.(1348-1350)AAG>AAC	p.K450N		NM_015904	NP_056988	O60841	IF2P_HUMAN	eukaryotic translation initiation factor 5B	450					regulation of translational initiation	cytosol	GTP binding|GTPase activity|protein binding|translation initiation factor activity			ovary(2)|pancreas(1)	3						AAGATAAAAAGAGGAAAAAAA	0.353	Colon(162;2388 2567 2705 3444)		NA											7	31					0	0	0.00308	0	0
NCK2	8440	broad.mit.edu	37	2	106498084	106498084	+	Missense_Mutation	SNP	C	C	G			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr2:106498084C>G	uc002tdg.2	+	4	969	c.527C>G	c.(526-528)TCC>TGC	p.S176C	NCK2_uc002tdh.2_Intron|NCK2_uc002tdi.2_Missense_Mutation_p.S176C	NM_003581	NP_003572	O43639	NCK2_HUMAN	NCK adaptor protein 2 isoform A	176					axon guidance|epidermal growth factor receptor signaling pathway|negative regulation of cell proliferation|positive regulation of actin filament polymerization|positive regulation of T cell proliferation|regulation of epidermal growth factor receptor activity|regulation of translation|signal complex assembly|T cell activation	cytosol|endoplasmic reticulum	cytoskeletal adaptor activity|receptor signaling complex scaffold activity			ovary(1)|lung(1)	2						GCTGCGGAGTCCCCAAGCTTC	0.657			NA											8	103					0	0	0.00308	0	0
SLC5A7	60482	broad.mit.edu	37	2	108609503	108609503	+	Missense_Mutation	SNP	G	G	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr2:108609503G>A	uc002tdv.2	+	4	644	c.368G>A	c.(367-369)GGA>GAA	p.G123E	SLC5A7_uc010ywm.1_5'UTR|SLC5A7_uc010fjj.2_Missense_Mutation_p.G123E|SLC5A7_uc010ywn.1_Missense_Mutation_p.G10E	NM_021815	NP_068587	Q9GZV3	SC5A7_HUMAN	solute carrier family 5 (choline transporter),	123	Extracellular (Potential).				acetylcholine biosynthetic process|neurotransmitter secretion	integral to membrane|plasma membrane	choline:sodium symporter activity			ovary(2)|central_nervous_system(1)|skin(1)	4					Choline(DB00122)	CAAATCTATGGAAAACGCATG	0.448			NA											14	57					0	0	0.00245	0	0
SH3RF3	344558	broad.mit.edu	37	2	110048969	110048969	+	Silent	SNP	C	C	G			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr2:110048969C>G	uc010ywt.1	+	6	1416	c.1416C>G	c.(1414-1416)CTC>CTG	p.L472L		NM_001099289	NP_001092759	Q8TEJ3	SH3R3_HUMAN	SH3 domain containing ring finger 3	472	SH3 3.						zinc ion binding			ovary(1)	1						ACCTGGCGCTCTACGCCTACA	0.632			NA											12	15					0	0	0.001855	0	0
BUB1	699	broad.mit.edu	37	2	111395637	111395637	+	Silent	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr2:111395637C>T	uc002tgc.2	-	25	3274	c.3162G>A	c.(3160-3162)CTG>CTA	p.L1054L	BUB1_uc010yxh.1_Silent_p.L1034L|BUB1_uc010fkb.2_Silent_p.L997L	NM_004336	NP_004327	O43683	BUB1_HUMAN	budding uninhibited by benzimidazoles 1	1054	Protein kinase.				apoptosis|cell division|chromosome segregation|interspecies interaction between organisms|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|regulation of sister chromatid cohesion	condensed chromosome kinetochore|cytosol	ATP binding|protein binding|protein serine/threonine kinase activity			lung(2)|breast(2)|stomach(1)|ovary(1)|kidney(1)	7		Ovarian(717;0.0822)		BRCA - Breast invasive adenocarcinoma(221;0.0556)		ATACTTTCTTCAGCTTTTGCC	0.338			NA											10	22					0	0	0.008291	0	0
BUB1	699	broad.mit.edu	37	2	111425235	111425235	+	Nonsense_Mutation	SNP	G	G	C			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr2:111425235G>C	uc002tgc.2	-	8	780	c.668C>G	c.(667-669)TCA>TGA	p.S223*	BUB1_uc010yxh.1_Nonsense_Mutation_p.S203*|BUB1_uc010fkb.2_Nonsense_Mutation_p.S223*|BUB1_uc002tgd.2_Nonsense_Mutation_p.S223*	NM_004336	NP_004327	O43683	BUB1_HUMAN	budding uninhibited by benzimidazoles 1	223					apoptosis|cell division|chromosome segregation|interspecies interaction between organisms|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|regulation of sister chromatid cohesion	condensed chromosome kinetochore|cytosol	ATP binding|protein binding|protein serine/threonine kinase activity	p.V221_S227>S(1)		lung(2)|breast(2)|stomach(1)|ovary(1)|kidney(1)	7		Ovarian(717;0.0822)		BRCA - Breast invasive adenocarcinoma(221;0.0556)		TGCCAAAGATGAGTGCACAGA	0.378			NA											8	47					0	0	0.00308	0	0
TTL	150465	broad.mit.edu	37	2	113286318	113286318	+	Silent	SNP	A	A	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr2:113286318A>T	uc002thu.2	+	7	1259	c.1080A>T	c.(1078-1080)CCA>CCT	p.P360P	TTL_uc010fkm.1_Intron	NM_153712	NP_714923	Q8NG68	TTL_HUMAN	tubulin tyrosine ligase	360	TTL.				protein modification process		ATP binding|tubulin-tyrosine ligase activity				0		Ovarian(717;0.024)		BRCA - Breast invasive adenocarcinoma(221;6.17e-07)|STAD - Stomach adenocarcinoma(1183;0.00644)		GTGTCTTCCCACCCCCAGATG	0.512			NA	T	ETV6	ALL								32	62					0	0	0.013726	0	0
IL1A	3552	broad.mit.edu	37	2	113539390	113539390	+	Missense_Mutation	SNP	T	T	C			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr2:113539390T>C	uc002tig.2	-	4	1070	c.110A>G	c.(109-111)CAT>CGT	p.H37R		NM_000575	NP_000566	P01583	IL1A_HUMAN	interleukin 1, alpha proprotein	37					anti-apoptosis|apoptosis|cell proliferation|cellular response to heat|cytokine-mediated signaling pathway|fever generation|immune response|negative regulation of cell proliferation|positive regulation of angiogenesis|positive regulation of cell division|positive regulation of cytokine secretion|positive regulation of interleukin-2 biosynthetic process|positive regulation of mitosis|positive regulation vascular endothelial growth factor production|response to copper ion	cytosol|extracellular space	copper ion binding|cytokine activity|interleukin-1 receptor binding			lung(1)	1						ATAGCTTACATGATAGAAGGA	0.443			NA											23	27					0	0	0.00333	0	0
PSD4	23550	broad.mit.edu	37	2	113955199	113955199	+	Silent	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr2:113955199C>T	uc002tjc.2	+	13	2628	c.2445C>T	c.(2443-2445)CTC>CTT	p.L815L	PSD4_uc002tjd.2_Silent_p.L436L|PSD4_uc002tje.2_Silent_p.L786L|PSD4_uc002tjf.2_Silent_p.L436L|PSD4_uc002tjg.2_5'UTR|PSD4_uc010yxs.1_Silent_p.L46L|PSD4_uc002tjh.2_5'Flank	NM_012455	NP_036587	Q8NDX1	PSD4_HUMAN	pleckstrin and Sec7 domain containing 4	815	PH.				regulation of ARF protein signal transduction	cytoplasm|plasma membrane	ARF guanyl-nucleotide exchange factor activity			ovary(2)	2						GGATGGTTCTCTACTTCCTGA	0.552			NA											23	49					0	0	0.014323	0	0
DDX11L2	84771	broad.mit.edu	37	2	114357557	114357557	+	Nonstop_Mutation	SNP	A	A	G	rs115341812	by1000genomes	TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr2:114357557A>G	uc010yxx.1	-	3	709	c.382T>C	c.(382-384)TAG>CAG	p.*128Q						SubName: Full=DEAD/H box polypeptide 11 like 2;												0						GCCTACTTCTAGTGAAACTGG	0.567			NA											3	25					0	0	0.004672	0	0
DDX18	8886	broad.mit.edu	37	2	118579310	118579310	+	Silent	SNP	G	G	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr2:118579310G>A	uc002tlh.1	+	5	834	c.735G>A	c.(733-735)AGG>AGA	p.R245R		NM_006773	NP_006764	Q9NVP1	DDX18_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 18	245	Helicase ATP-binding.						ATP binding|ATP-dependent RNA helicase activity|RNA binding			breast(2)|ovary(1)|lung(1)	4						TTAAGTTAAGGTTCATGCCCA	0.423			NA											9	35					0	0	0.004482	0	0
GLI2	2736	broad.mit.edu	37	2	121747078	121747078	+	Silent	SNP	G	G	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr2:121747078G>T	uc010flp.2	+	13	3618	c.3588G>T	c.(3586-3588)GGG>GGT	p.G1196G	GLI2_uc002tmq.1_Intron|GLI2_uc002tmr.1_Intron|GLI2_uc002tmt.3_Silent_p.G868G|GLI2_uc002tmu.3_Silent_p.G851G	NM_005270	NP_005261	P10070	GLI2_HUMAN	GLI-Kruppel family member GLI2	1196					axon guidance|branching morphogenesis of a tube|cell proliferation|cerebellar cortex morphogenesis|developmental growth|embryonic digestive tract development|epidermal cell differentiation|floor plate formation|heart development|hindgut morphogenesis|kidney development|lung development|negative regulation of transcription from RNA polymerase II promoter|odontogenesis of dentine-containing tooth|osteoblast development|osteoblast differentiation|pituitary gland development|positive regulation of DNA replication|positive regulation of T cell differentiation in thymus|positive regulation of transcription from RNA polymerase II promoter|proximal/distal pattern formation|skeletal system development|smoothened signaling pathway involved in ventral spinal cord interneuron specification|spinal cord ventral commissure morphogenesis	nucleus|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|lung(2)|breast(1)|central_nervous_system(1)|pancreas(1)	13	Renal(3;0.0496)	Prostate(154;0.0623)				CTAGCCCTGGGGGCCTGGACA	0.672			NA											22	32					1.37657e-19	1.85415e-19	0.012319	1	0
MAP3K2	10746	broad.mit.edu	37	2	128066163	128066163	+	Missense_Mutation	SNP	G	G	C			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr2:128066163G>C	uc002toj.1	-	15	1697	c.1632C>G	c.(1630-1632)ATC>ATG	p.I544M		NM_006609	NP_006600	Q9Y2U5	M3K2_HUMAN	mitogen-activated protein kinase kinase kinase	544	Protein kinase.				activation of JUN kinase activity|cellular response to mechanical stimulus	nucleus	ATP binding|MAP kinase kinase kinase activity|metal ion binding|protein kinase binding			lung(3)|ovary(2)|large_intestine(1)|central_nervous_system(1)	7	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0706)		AAACCTACCAGATGTCTGCTT	0.453			NA											40	207					0	0	0.009718	0	0
WDR33	55339	broad.mit.edu	37	2	128471546	128471546	+	Silent	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr2:128471546C>T	uc002tpg.1	-	18	3102	c.2919G>A	c.(2917-2919)AGG>AGA	p.R973R		NM_018383	NP_060853	Q9C0J8	WDR33_HUMAN	WD repeat domain 33 isoform 1	973					postreplication repair|spermatogenesis	collagen|nucleus	protein binding				0	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0695)		GCTCATGCCGCCTCTCTGACA	0.632			NA											28	69					0	0	0.003755	0	0
POLR2D	5433	broad.mit.edu	37	2	128610524	128610524	+	Nonsense_Mutation	SNP	T	T	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr2:128610524T>A	uc002tpj.2	-	2	284	c.229A>T	c.(229-231)AGA>TGA	p.R77*	POLR2D_uc002tpk.2_Nonsense_Mutation_p.R77*	NM_004805	NP_004796	O15514	RPB4_HUMAN	DNA directed RNA polymerase II polypeptide D	77					mRNA capping|nuclear mRNA splicing, via spliceosome|positive regulation of viral transcription|protein phosphorylation|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	DNA-directed RNA polymerase II, core complex	DNA-directed RNA polymerase activity|nucleotide binding				0	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0675)		ATGGTCTCTCTGTTTTTGAAA	0.438			NA											23	132					0	0	0.00278	0	0
CCDC74B	91409	broad.mit.edu	37	2	130899923	130899923	+	Silent	SNP	G	G	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr2:130899923G>A	uc002tqm.1	-	3	389	c.327C>T	c.(325-327)GCC>GCT	p.A109A	CCDC74B_uc010yzw.1_Silent_p.A211A|CCDC74B_uc002tqn.1_Intron|CCDC74B_uc010yzx.1_3'UTR	NM_207310	NP_997193	Q96LY2	CC74B_HUMAN	coiled-coil domain containing 74B	109											0	Colorectal(110;0.1)					AGGGAGCAGAGGCCCTGGAAA	0.647			NA											17	44					0	0	0.00278	0	0
CCDC74A	90557	broad.mit.edu	37	2	132288183	132288183	+	Silent	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr2:132288183C>T	uc002tta.2	+	3	379	c.327C>T	c.(325-327)GCC>GCT	p.A109A	CCDC74A_uc002ttb.2_Intron	NM_138770	NP_620125	Q96AQ1	CC74A_HUMAN	coiled-coil domain containing 74A	109										skin(1)	1						TTTCCAGGGCCTCTGCTCCCT	0.642			NA											9	72					0	0	0.00499	0	0
GPR39	2863	broad.mit.edu	37	2	133403100	133403100	+	Missense_Mutation	SNP	T	T	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr2:133403100T>A	uc002ttl.2	+	2	1752	c.1283T>A	c.(1282-1284)CTC>CAC	p.L428H	LYPD1_uc002ttm.3_3'UTR|LYPD1_uc002ttn.2_3'UTR|LYPD1_uc002tto.2_3'UTR	NM_001508	NP_001499	O43194	GPR39_HUMAN	G protein-coupled receptor 39	428	Cytoplasmic (Potential).					integral to plasma membrane	G-protein coupled receptor activity|metal ion binding				0						TCATTGAGTCTCGAGTCACTA	0.532			NA											34	54					0	0	0.003755	0	0
YSK4	80122	broad.mit.edu	37	2	135745530	135745530	+	Missense_Mutation	SNP	C	C	G			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr2:135745530C>G	uc002tue.1	-	7	943	c.912G>C	c.(910-912)AAG>AAC	p.K304N	YSK4_uc002tuf.1_Intron|YSK4_uc010fnc.1_Intron|YSK4_uc010fnd.1_Missense_Mutation_p.K191N|YSK4_uc010zbg.1_Intron|YSK4_uc002tuh.3_Missense_Mutation_p.K32N|YSK4_uc002tui.3_Missense_Mutation_p.K321N	NM_025052	NP_079328	Q56UN5	YSK4_HUMAN	Yeast Sps1/Ste20-related kinase 4 isoform 1	304							ATP binding|protein serine/threonine kinase activity			stomach(2)|urinary_tract(1)|ovary(1)|breast(1)	5				BRCA - Breast invasive adenocarcinoma(221;0.112)		AGTTTTCCTCCTTCTCCAGGC	0.408			NA											8	67					0	0	0.004482	0	0
CXCR4	7852	broad.mit.edu	37	2	136872465	136872465	+	Missense_Mutation	SNP	C	C	G			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr2:136872465C>G	uc002tuz.2	-	2	1128	c.1033G>C	c.(1033-1035)GAG>CAG	p.E345Q	CXCR4_uc002tuy.2_Missense_Mutation_p.E349Q|CXCR4_uc010fnk.2_Missense_Mutation_p.E330Q	NM_003467	NP_003458	P61073	CXCR4_HUMAN	chemokine (C-X-C motif) receptor 4 isoform b	345	Cytoplasmic.				activation of MAPK activity|apoptosis|dendritic cell chemotaxis|elevation of cytosolic calcium ion concentration|entry into host cell|inflammatory response|initiation of viral infection|regulation of chemotaxis|response to hypoxia|response to virus	cell leading edge|cell surface|cytoplasmic membrane-bounded vesicle|integral to membrane|plasma membrane	actin binding|C-X-C chemokine receptor activity|coreceptor activity|myosin light chain binding|ubiquitin binding|ubiquitin protein ligase binding			upper_aerodigestive_tract(1)|large_intestine(1)|lung(1)	3				BRCA - Breast invasive adenocarcinoma(221;0.155)	Framycetin(DB00452)	CTTGAAGACTCAGACTCAGTG	0.403			NA											111	288					0	0	0.01441	0	0
LRP1B	53353	broad.mit.edu	37	2	141773472	141773472	+	Missense_Mutation	SNP	C	C	G			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr2:141773472C>G	uc002tvj.1	-	13	2955	c.1983G>C	c.(1981-1983)TGG>TGC	p.W661C	LRP1B_uc010fnl.1_Intron	NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	661	Extracellular (Potential).|LDL-receptor class B 7.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		CCCAGTCTGTCCAATACATCC	0.403	Colon(99;50 2074 2507 20106)		NA								TSP Lung(27;0.18)			9	63					0	0	0.004482	0	0
ZEB2	9839	broad.mit.edu	37	2	145156847	145156847	+	Nonsense_Mutation	SNP	A	A	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr2:145156847A>T	uc002tvu.2	-	8	2387	c.1907T>A	c.(1906-1908)TTG>TAG	p.L636*	ZEB2_uc002tvv.2_Nonsense_Mutation_p.L630*|ZEB2_uc010zbm.1_Nonsense_Mutation_p.L607*|ZEB2_uc010fnp.2_Intron|ZEB2_uc010fnq.1_Nonsense_Mutation_p.L665*	NM_014795	NP_055610	O60315	ZEB2_HUMAN	zinc finger homeobox 1b	636						cytoplasm|nucleolus	phosphatase regulator activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|SMAD binding|zinc ion binding			ovary(5)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)	9				BRCA - Breast invasive adenocarcinoma(221;0.112)		TACAGATGACAAGAGGAGGGC	0.443	Melanoma(33;1235 1264 5755 16332)		NA											6	60					0	0	0.001984	0	0
LYPD6B	130576	broad.mit.edu	37	2	150071151	150071151	+	Missense_Mutation	SNP	G	G	C			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr2:150071151G>C	uc002twv.1	+	7	952	c.551G>C	c.(550-552)AGA>ACA	p.R184T	LYPD6B_uc002tww.1_Missense_Mutation_p.R146T|LYPD6B_uc002twx.1_Missense_Mutation_p.R146T	NM_177964	NP_808879	Q8NI32	LPD6B_HUMAN	LY6/PLAUR domain containing 6B	160						anchored to membrane|plasma membrane					0						CACGCTCAGAGAACATCTGGC	0.498			NA											23	178					0	0	0.014323	0	0
KCNJ3	3760	broad.mit.edu	37	2	155555776	155555776	+	Silent	SNP	C	C	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr2:155555776C>A	uc002tyv.1	+	1	684	c.489C>A	c.(487-489)CTC>CTA	p.L163L	KCNJ3_uc010zce.1_Silent_p.L163L	NM_002239	NP_002230	P48549	IRK3_HUMAN	potassium inwardly-rectifying channel J3	163	Helical; Name=M2; (By similarity).				synaptic transmission	voltage-gated potassium channel complex	G-protein activated inward rectifier potassium channel activity|protein binding			upper_aerodigestive_tract(1)|pancreas(1)	2					Halothane(DB01159)	TCCTCTTCCTCTTCCAGTCCA	0.572			NA											9	85					1.12685e-05	1.25378e-05	0.004482	1	0
DPP4	1803	broad.mit.edu	37	2	162876803	162876803	+	Missense_Mutation	SNP	A	A	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr2:162876803A>T	uc002ubz.2	-	14	1741	c.1180T>A	c.(1180-1182)TGC>AGC	p.C394S	DPP4_uc010fpb.2_Missense_Mutation_p.C70S	NM_001935	NP_001926	P27487	DPP4_HUMAN	dipeptidylpeptidase IV	394	Extracellular (Potential).				cell adhesion|endothelial cell migration|negative regulation of extracellular matrix disassembly|positive regulation of cell proliferation|proteolysis|regulation of cell-cell adhesion mediated by integrin|response to hypoxia|T cell activation|T cell costimulation	apical plasma membrane|cell surface|endocytic vesicle|extracellular region|integral to membrane|invadopodium membrane|lamellipodium membrane|membrane raft	aminopeptidase activity|dipeptidyl-peptidase activity|protease binding|protein homodimerization activity|receptor activity|receptor binding|serine-type endopeptidase activity			ovary(3)	3					Sitagliptin(DB01261)	ATAAATGTGCAGTCCTGATGG	0.318			NA											4	40					0	0	0.009096	0	0
SCN2A	6326	broad.mit.edu	37	2	166211047	166211047	+	Missense_Mutation	SNP	G	G	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr2:166211047G>A	uc002udc.2	+	17	3555	c.3265G>A	c.(3265-3267)GAA>AAA	p.E1089K	SCN2A_uc002udd.2_Missense_Mutation_p.E1089K|SCN2A_uc002ude.2_Missense_Mutation_p.E1089K	NM_001040142	NP_001035232	Q99250	SCN2A_HUMAN	sodium channel, voltage-gated, type II, alpha	1089					myelination	node of Ranvier|voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|breast(1)|pancreas(1)	8					Lamotrigine(DB00555)	TGTCGTGGATGAAAGTGATTA	0.373			NA											8	41					0	0	0.004482	0	0
SCN2A	6326	broad.mit.edu	37	2	166211143	166211143	+	Missense_Mutation	SNP	G	G	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr2:166211143G>A	uc002udc.2	+	17	3651	c.3361G>A	c.(3361-3363)GAA>AAA	p.E1121K	SCN2A_uc002udd.2_Missense_Mutation_p.E1121K|SCN2A_uc002ude.2_Missense_Mutation_p.E1121K	NM_001040142	NP_001035232	Q99250	SCN2A_HUMAN	sodium channel, voltage-gated, type II, alpha	1121					myelination	node of Ranvier|voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|breast(1)|pancreas(1)	8					Lamotrigine(DB00555)	AAATACTGAAGAATTCAGCAG	0.323			NA											6	32					0	0	0.001168	0	0
SCN1A	6323	broad.mit.edu	37	2	166930006	166930006	+	Missense_Mutation	SNP	T	T	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr2:166930006T>A	uc010zcz.1	-	1	144	c.126A>T	c.(124-126)AAA>AAT	p.K42N		NM_006920	NP_008851	P35498	SCN1A_HUMAN	sodium channel, voltage-gated, type I, alpha	42						voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|skin(6)|large_intestine(1)	13					Lamotrigine(DB00555)|Levetiracetam(DB01202)|Phenacemide(DB01121)|Phenytoin(DB00252)|Topiramate(DB00273)|Zonisamide(DB00909)	CGTCGTCATCTTTTTTGTCTG	0.443			NA											119	107					0	0	0.01441	0	0
XIRP2	129446	broad.mit.edu	37	2	168106754	168106754	+	Missense_Mutation	SNP	G	G	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr2:168106754G>T	uc002udx.2	+	8	8870	c.8852G>T	c.(8851-8853)CGT>CTT	p.R2951L	XIRP2_uc010fpn.2_Intron|XIRP2_uc010fpo.2_Intron|XIRP2_uc010fpp.2_Intron|XIRP2_uc002udy.2_Missense_Mutation_p.R2776L|XIRP2_uc010fpq.2_Missense_Mutation_p.R2729L|XIRP2_uc010fpr.2_Intron|XIRP2_uc010fps.1_Missense_Mutation_p.R297L	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	2776	Potential.				actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14						TTGAGAAAACGTGAAGAACTG	0.373			NA											47	41					4.10826e-27	5.67573e-27	0.01441	1	0
LRP2	4036	broad.mit.edu	37	2	170112651	170112651	+	Missense_Mutation	SNP	T	T	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr2:170112651T>A	uc002ues.2	-	19	2948	c.2735A>T	c.(2734-2736)CAG>CTG	p.Q912L	LRP2_uc010zdf.1_Missense_Mutation_p.Q775L	NM_004525	NP_004516	P98164	LRP2_HUMAN	low density lipoprotein-related protein 2	912	LDL-receptor class B 9.|Extracellular (Potential).				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			ovary(13)|skin(6)|central_nervous_system(4)|large_intestine(3)|kidney(2)|pancreas(1)	29				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	ATGTGTCATCTGCTCTATATG	0.363			NA											23	23					0	0	0.00333	0	0
GAD1	2571	broad.mit.edu	37	2	171715359	171715359	+	Missense_Mutation	SNP	A	A	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr2:171715359A>T	uc002ugi.2	+	16	1989	c.1567A>T	c.(1567-1569)AGG>TGG	p.R523W	GAD1_uc010fqc.2_Missense_Mutation_p.R142W	NM_000817	NP_000808	Q99259	DCE1_HUMAN	glutamate decarboxylase 1 isoform GAD67	523					glutamate decarboxylation to succinate|neurotransmitter biosynthetic process|neurotransmitter secretion|protein-pyridoxal-5-phosphate linkage	clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|plasma membrane	glutamate decarboxylase activity|protein binding|pyridoxal phosphate binding			ovary(1)	1					L-Glutamic Acid(DB00142)|Pyridoxal Phosphate(DB00114)	ACAAAGCCTCAGGGGTGTGCC	0.438			NA											17	15					0	0	0.006122	0	0
WIPF1	7456	broad.mit.edu	37	2	175436880	175436880	+	Missense_Mutation	SNP	G	G	C			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr2:175436880G>C	uc002uiy.2	-	6	985	c.653C>G	c.(652-654)ACT>AGT	p.T218S	uc002uiw.2_Intron|uc002uix.1_Intron|WIPF1_uc002uja.2_Missense_Mutation_p.T218S|WIPF1_uc010fqt.1_Missense_Mutation_p.T218S|WIPF1_uc002ujc.1_Missense_Mutation_p.T218S|WIPF1_uc002uiz.2_Missense_Mutation_p.T218S|WIPF1_uc002ujb.1_Missense_Mutation_p.T218S|WIPF1_uc010zep.1_Missense_Mutation_p.T218S	NM_003387	NP_003378	O43516	WIPF1_HUMAN	WAS/WASL interacting protein family, member 1	218					actin polymerization or depolymerization|protein complex assembly	cytoplasmic membrane-bounded vesicle	actin binding|profilin binding			ovary(1)|skin(1)	2						AGGGGGAGGAGTGGGCCCGGG	0.657			NA											12	106					0	0	0.00245	0	0
CHRNA1	1134	broad.mit.edu	37	2	175614714	175614714	+	Missense_Mutation	SNP	C	C	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr2:175614714C>A	uc002ujd.2	-	8	1115	c.1037G>T	c.(1036-1038)CGC>CTC	p.R346L	uc002uiw.2_Intron|CHRNA1_uc002uje.2_Missense_Mutation_p.R321L	NM_001039523	NP_001034612	P02708	ACHA_HUMAN	nicotinic cholinergic receptor alpha 1 isoform a	346	Cytoplasmic.				muscle cell homeostasis|neuromuscular junction development|neuromuscular process|neuromuscular synaptic transmission|neuron homeostasis|regulation of action potential in neuron|skeletal muscle contraction|skeletal muscle tissue growth	cell junction|cell surface|neuromuscular junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity			ovary(2)|central_nervous_system(1)|skin(1)	4						GCTGGGTGAGCGGTGGTGTGT	0.557			NA											49	52					4.0306e-16	5.32039e-16	0.01441	1	0
TTN	7273	broad.mit.edu	37	2	179396241	179396241	+	Missense_Mutation	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr2:179396241C>T	uc010zfg.1	-	307	97621	c.97397G>A	c.(97396-97398)GGG>GAG	p.G32466E	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.G26161E|TTN_uc010zfi.1_Missense_Mutation_p.G26094E|TTN_uc010zfj.1_Missense_Mutation_p.G25969E|TTN_uc002umq.2_5'Flank	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	33393							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GGTATAATCCCCTCCTGTCAC	0.493			NA											38	43					0	0	0.004878	0	0
TTN	7273	broad.mit.edu	37	2	179407526	179407526	+	Missense_Mutation	SNP	C	C	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr2:179407526C>A	uc010zfg.1	-	297	89575	c.89351G>T	c.(89350-89352)CGT>CTT	p.R29784L	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.R23479L|TTN_uc010zfi.1_Missense_Mutation_p.R23412L|TTN_uc010zfj.1_Missense_Mutation_p.R23287L	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	30711							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AACTGTGACACGCTCTGATTC	0.458			NA											18	122					7.81268e-19	1.0494e-18	0.00499	1	0
TTN	7273	broad.mit.edu	37	2	179451993	179451993	+	Silent	SNP	G	G	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr2:179451993G>T	uc010zfg.1	-	256	56465	c.56241C>A	c.(56239-56241)ACC>ACA	p.T18747T	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Silent_p.T12442T|TTN_uc010zfi.1_Silent_p.T12375T|TTN_uc010zfj.1_Silent_p.T12250T	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	19674							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CTGGGGTAACGGTCGACCATG	0.488			NA											13	68					0.00136819	0.00143231	0.013537	1	0
TTN	7273	broad.mit.edu	37	2	179516838	179516838	+	Missense_Mutation	SNP	T	T	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr2:179516838T>A	uc010zfg.1	-	158	32202	c.31978A>T	c.(31978-31980)AGT>TGT	p.S10660C	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc010fre.1_Intron|TTN_uc002umw.1_5'Flank|TTN_uc002umx.1_5'Flank	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	11587							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GGGGGAGGACTTTCCGGTTTG	0.348			NA											22	83					0	0	0.00278	0	0
TTN	7273	broad.mit.edu	37	2	179575833	179575833	+	Missense_Mutation	SNP	T	T	G			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr2:179575833T>G	uc010zfg.1	-	94	24622	c.24398A>C	c.(24397-24399)AAC>ACC	p.N8133T	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.N4794T	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	9060							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GCCTATAGGGTTTGTAGCTGT	0.383			NA											5	106					0	0	0.001168	0	0
TTN	7273	broad.mit.edu	37	2	179596652	179596652	+	Missense_Mutation	SNP	C	C	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr2:179596652C>A	uc010zfg.1	-	55	13442	c.13218G>T	c.(13216-13218)AAG>AAT	p.K4406N	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.K1067N	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	5333							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CATCGTACTCCTTTAAGACTT	0.433			NA											18	64					1.67942e-08	2.01031e-08	0.006122	1	0
TTN	7273	broad.mit.edu	37	2	179599169	179599169	+	Missense_Mutation	SNP	A	A	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr2:179599169A>T	uc010zfg.1	-	49	11874	c.11650T>A	c.(11650-11652)TCT>ACT	p.S3884T	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.S545T	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	4811							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CACACAAGAGACTTCTGAGAA	0.393			NA											23	67					0	0	0.012319	0	0
TTN	7273	broad.mit.edu	37	2	179612234	179612234	+	Missense_Mutation	SNP	G	G	C			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr2:179612234G>C	uc002unb.2	-	46	15117	c.14893C>G	c.(14893-14895)CCT>GCT	p.P4965A	TTN_uc010zfg.1_Intron|TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Intron	NM_133379	NP_596870	Q8WZ42	TITIN_HUMAN	titin isoform novex-3	1082							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCAGACTCAGGAGAAAGTGGA	0.393			NA											11	74					0	0	0.008291	0	0
TTN	7273	broad.mit.edu	37	2	179640848	179640848	+	Missense_Mutation	SNP	C	C	G			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr2:179640848C>G	uc010zfg.1	-	28	5967	c.5743G>C	c.(5743-5745)GAA>CAA	p.E1915Q	TTN_uc010zfh.1_Missense_Mutation_p.E1869Q|TTN_uc010zfi.1_Missense_Mutation_p.E1869Q|TTN_uc010zfj.1_Missense_Mutation_p.E1869Q|TTN_uc002unb.2_Missense_Mutation_p.E1915Q|uc002unc.1_5'Flank	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	1915							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCAGGATTTTCCGCGGTGACC	0.463			NA											36	221					0	0	0.003755	0	0
TTN	7273	broad.mit.edu	37	2	179641721	179641721	+	Missense_Mutation	SNP	C	C	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr2:179641721C>A	uc010zfg.1	-	28	5094	c.4870G>T	c.(4870-4872)GAT>TAT	p.D1624Y	TTN_uc010zfh.1_Missense_Mutation_p.D1578Y|TTN_uc010zfi.1_Missense_Mutation_p.D1578Y|TTN_uc010zfj.1_Missense_Mutation_p.D1578Y|TTN_uc002unb.2_Missense_Mutation_p.D1624Y|uc002unc.1_RNA	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	1624							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CAGGCAGAATCTTGGCTGACA	0.423			NA											27	37					7.92952e-12	1.00032e-11	0.003954	1	0
ZNF804A	91752	broad.mit.edu	37	2	185801543	185801543	+	Missense_Mutation	SNP	G	G	C			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr2:185801543G>C	uc002uph.2	+	4	2014	c.1420G>C	c.(1420-1422)GAT>CAT	p.D474H		NM_194250	NP_919226	Q7Z570	Z804A_HUMAN	zinc finger protein 804A	474						intracellular	zinc ion binding			ovary(6)|skin(3)|large_intestine(1)|pancreas(1)	11						TAATAATCTAGATAAAAATAA	0.343			NA											31	28					0	0	0.008361	0	0
COL3A1	1281	broad.mit.edu	37	2	189839268	189839268	+	Missense_Mutation	SNP	C	C	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr2:189839268C>A	uc002uqj.1	+	1	170	c.53C>A	c.(52-54)CCC>CAC	p.P18H		NM_000090	NP_000081	P02461	CO3A1_HUMAN	collagen type III alpha 1 preproprotein	18					axon guidance|cell-matrix adhesion|collagen biosynthetic process|collagen fibril organization|fibril organization|heart development|integrin-mediated signaling pathway|negative regulation of immune response|peptide cross-linking|platelet activation|response to cytokine stimulus|response to radiation|skin development|transforming growth factor beta receptor signaling pathway	collagen type III|extracellular space	extracellular matrix structural constituent|integrin binding|platelet-derived growth factor binding			central_nervous_system(7)|ovary(4)|large_intestine(2)	13			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.141)		Collagenase(DB00048)|Palifermin(DB00039)	CTGCTTCATCCCACTATTATT	0.408			NA											7	40					0.00307968	0.00319864	0.00308	1	0
COL3A1	1281	broad.mit.edu	37	2	189866142	189866142	+	Missense_Mutation	SNP	G	G	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr2:189866142G>T	uc002uqj.1	+	33	2420	c.2303G>T	c.(2302-2304)GGT>GTT	p.G768V		NM_000090	NP_000081	P02461	CO3A1_HUMAN	collagen type III alpha 1 preproprotein	768	Triple-helical region.				axon guidance|cell-matrix adhesion|collagen biosynthetic process|collagen fibril organization|fibril organization|heart development|integrin-mediated signaling pathway|negative regulation of immune response|peptide cross-linking|platelet activation|response to cytokine stimulus|response to radiation|skin development|transforming growth factor beta receptor signaling pathway	collagen type III|extracellular space	extracellular matrix structural constituent|integrin binding|platelet-derived growth factor binding			central_nervous_system(7)|ovary(4)|large_intestine(2)	13			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.141)		Collagenase(DB00048)|Palifermin(DB00039)	GGTCCTATTGGTCCTCCTGGC	0.368			NA											6	69					3.59834e-05	3.94026e-05	0.001168	1	0
DNAH7	56171	broad.mit.edu	37	2	196664137	196664137	+	Silent	SNP	T	T	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr2:196664137T>A	uc002utj.3	-	55	10337	c.10236A>T	c.(10234-10236)CCA>CCT	p.P3412P		NM_018897	NP_061720	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	3412	AAA 6 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			skin(10)|ovary(2)	12						CAAAGGGGGGTGGTTCAATGA	0.428			NA											12	91					0	0	0.013537	0	0
ANKRD44	91526	broad.mit.edu	37	2	198051794	198051794	+	Missense_Mutation	SNP	C	C	G			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr2:198051794C>G	uc002uuc.2	-	2	231	c.64G>C	c.(64-66)GAG>CAG	p.E22Q	ANKRD44_uc002uua.1_5'UTR|ANKRD44_uc002uub.2_Missense_Mutation_p.E22Q|ANKRD44_uc010zgw.1_5'UTR|ANKRD44_uc002uud.1_Missense_Mutation_p.E22Q	NM_153697	NP_710181	Q8N8A2	ANR44_HUMAN	ankyrin repeat domain 44	22	ANK 1.						protein binding			ovary(4)|skin(1)	5			OV - Ovarian serous cystadenocarcinoma(117;0.246)			CGGATCTCCTCTGGATCACCG	0.443			NA											34	124					0	0	0.012213	0	0
MOBKL3	25843	broad.mit.edu	37	2	198400314	198400314	+	Missense_Mutation	SNP	G	G	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr2:198400314G>A	uc002uun.3	+	3	224	c.184G>A	c.(184-186)GAA>AAA	p.E62K	MOBKL3_uc002uum.3_Missense_Mutation_p.E30K|MOBKL3_uc010fsn.2_Missense_Mutation_p.E41K|MOBKL3_uc010fso.2_Intron|MOBKL3_uc010zgz.1_5'UTR	NM_015387	NP_056202	Q9Y3A3	MOBL3_HUMAN	Mps One Binder kinase activator-like 3 isoform	62					transport	Golgi cisterna membrane|perinuclear region of cytoplasm	metal ion binding|protein binding				0			Epithelial(96;0.225)			TGAACCACCTGAAGGCCAAGA	0.318			NA											53	51					0	0	0.01441	0	0
PLCL1	5334	broad.mit.edu	37	2	198953721	198953721	+	Missense_Mutation	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr2:198953721C>T	uc010fsp.2	+	3	3146	c.2855C>T	c.(2854-2856)CCT>CTT	p.P952L	PLCL1_uc002uuv.3_Missense_Mutation_p.P873L	NM_001114661	NP_001108133	Q15111	PLCL1_HUMAN	RecName: Full=Inactive phospholipase C-like protein 1;          Short=PLC-L1; AltName: Full=Phospholipase C-deleted in lung carcinoma; AltName: Full=Phospholipase C-related but catalytically inactive protein;          Short=PRIP;	952					intracellular signal transduction|lipid metabolic process	cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			ovary(1)|skin(1)	2					Quinacrine(DB01103)	GACAGCTTTCCTTACCTGGAG	0.453			NA											57	74					0	0	0.01441	0	0
CFLAR	8837	broad.mit.edu	37	2	201994633	201994633	+	Silent	SNP	A	A	C			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr2:201994633A>C	uc002uxb.3	+	2	497	c.45A>C	c.(43-45)ACA>ACC	p.T15T	CFLAR_uc002uwy.2_Silent_p.T15T|CFLAR_uc002uwz.2_Silent_p.T15T|CFLAR_uc002uxa.3_Silent_p.T15T|CFLAR_uc010zhk.1_Intron|CFLAR_uc002uxc.3_Silent_p.T15T|CFLAR_uc010zhl.1_Intron|CFLAR_uc010fsw.1_RNA|CFLAR_uc002uxd.3_Silent_p.T15T|CFLAR_uc002uxe.2_Silent_p.T15T|CFLAR_uc002uxf.2_Silent_p.T15T|CFLAR_uc010fsy.2_RNA|CFLAR_uc010fsx.2_Silent_p.T15T	NM_003879	NP_003870	O15519	CFLAR_HUMAN	CASP8 and FADD-like apoptosis regulator isoform	15	Interaction with FADD.|Interaction with caspase-8.|DED 1.|Interaction with caspase-8 propeptide.|Not proteolytically processed and involved in apoptosis inhibition.				anti-apoptosis|apoptosis|induction of apoptosis by extracellular signals|interspecies interaction between organisms|positive regulation of I-kappaB kinase/NF-kappaB cascade|proteolysis		cysteine-type endopeptidase activity|protein binding				0						CACTTGATACAGATGAGAAGG	0.478	Pancreas(16;548 657 22190 32864 42338)		NA											16	186					0	0	0.004007	0	0
ALS2CR12	130540	broad.mit.edu	37	2	202207129	202207129	+	Missense_Mutation	SNP	C	C	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr2:202207129C>A	uc010ftg.2	-	7	932	c.488G>T	c.(487-489)TGT>TTT	p.C163F	ALS2CR12_uc002uya.3_Missense_Mutation_p.C163F|ALS2CR12_uc010fth.2_Intron	NM_139163	NP_631902	Q96Q35	AL2SB_HUMAN	amyotrophic lateral sclerosis 2 (juvenile)	163	Potential.				regulation of GTPase activity		protein binding			ovary(1)|breast(1)|central_nervous_system(1)	3						CATCTCAGCACAGCGGAGATC	0.483			NA											15	12					2.23348e-06	2.53163e-06	0.004007	1	0
BMPR2	659	broad.mit.edu	37	2	203421164	203421164	+	Missense_Mutation	SNP	G	G	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr2:203421164G>A	uc002uzf.3	+	12	3924	c.2776G>A	c.(2776-2778)GAT>AAT	p.D926N	BMPR2_uc010ftr.2_Intron	NM_001204	NP_001195	Q13873	BMPR2_HUMAN	bone morphogenetic protein receptor type II	926	Cytoplasmic (Potential).				anterior/posterior pattern formation|BMP signaling pathway|cellular response to starvation|lung alveolus development|mesoderm formation|negative regulation of cell growth|negative regulation of systemic arterial blood pressure|negative regulation of vasoconstriction|positive regulation of BMP signaling pathway|positive regulation of bone mineralization|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of epithelial cell migration|positive regulation of osteoblast differentiation|positive regulation of pathway-restricted SMAD protein phosphorylation|regulation of lung blood pressure|transcription from RNA polymerase II promoter|vascular endothelial growth factor receptor signaling pathway	integral to plasma membrane	ATP binding|metal ion binding|transforming growth factor beta receptor activity			ovary(4)|breast(2)|large_intestine(1)|stomach(1)|pancreas(1)	9						CACAGCAGCAGATCCTGGGCC	0.488			NA											6	167					0	0	0.001168	0	0
ICA1L	130026	broad.mit.edu	37	2	203653590	203653590	+	Silent	SNP	G	G	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr2:203653590G>A	uc002uzh.1	-	12	1370	c.1206C>T	c.(1204-1206)CTC>CTT	p.L402L	ICA1L_uc002uzi.1_Silent_p.L402L	NM_138468	NP_612477	Q8NDH6	ICA1L_HUMAN	islet cell autoantigen 1,69kDa-like isoform 1	402											0						CAAGGTCAAAGAGTTGTGAAG	0.483			NA											8	40					0	0	0.004482	0	0
RAPH1	65059	broad.mit.edu	37	2	204322288	204322288	+	Missense_Mutation	SNP	C	C	G			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr2:204322288C>G	uc002vad.2	-	8	1348	c.1123G>C	c.(1123-1125)GAG>CAG	p.E375Q	RAPH1_uc002vae.2_Missense_Mutation_p.E427Q|RAPH1_uc002vaf.2_Missense_Mutation_p.E427Q	NM_213589	NP_998754	Q70E73	RAPH1_HUMAN	Ras association and pleckstrin homology domains	375					cell-matrix adhesion|signal transduction	cytoplasm|cytoskeleton|filopodium|lamellipodium|nucleus|plasma membrane				ovary(3)|breast(3)|central_nervous_system(2)|lung(1)|skin(1)	10						TCTGCCATCTCAGCTGTTTCT	0.318			NA											8	164					0	0	0.006214	0	0
NRP2	8828	broad.mit.edu	37	2	206607987	206607987	+	Missense_Mutation	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr2:206607987C>T	uc002vaw.2	+	9	2143	c.1352C>T	c.(1351-1353)TCC>TTC	p.S451F	NRP2_uc002vat.2_Missense_Mutation_p.S451F|NRP2_uc002vau.2_Missense_Mutation_p.S451F|NRP2_uc002vav.2_Missense_Mutation_p.S451F|NRP2_uc002vax.2_Missense_Mutation_p.S451F|NRP2_uc002vay.2_Missense_Mutation_p.S451F|NRP2_uc010fud.2_Missense_Mutation_p.S451F	NM_201266	NP_957718	O60462	NRP2_HUMAN	neuropilin 2 isoform 1 precursor	451	Extracellular (Potential).|F5/8 type C 2.				angiogenesis|axon guidance|cell adhesion	integral to membrane|membrane fraction|plasma membrane	heparin binding|metal ion binding|semaphorin receptor activity|vascular endothelial growth factor receptor activity			skin(2)|ovary(1)|central_nervous_system(1)	4						TCCCAGATCTCCGCCTCTTCC	0.617			NA											45	312					0	0	0.01441	0	0
PIKFYVE	200576	broad.mit.edu	37	2	209218694	209218694	+	Missense_Mutation	SNP	G	G	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr2:209218694G>T	uc002vcz.2	+	40	6075	c.5917G>T	c.(5917-5919)GTC>TTC	p.V1973F		NM_015040	NP_055855	Q9Y2I7	FYV1_HUMAN	phosphatidylinositol-3-phosphate 5-kinase type	1973	Catalytic.|PIPK.				cellular protein metabolic process|intracellular signal transduction|protein localization to nucleus|retrograde transport, endosome to Golgi	early endosome membrane|membrane raft	1-phosphatidylinositol-3-phosphate 5-kinase activity|1-phosphatidylinositol-4-phosphate 5-kinase activity|ATP binding|metal ion binding|protein binding			ovary(5)|kidney(2)|pancreas(1)|central_nervous_system(1)|skin(1)	10						TTGTGATGTGGTCCTGCTAGA	0.393			NA											33	39					1.06801e-11	1.34381e-11	0.009535	1	0
VWC2L	402117	broad.mit.edu	37	2	215279129	215279129	+	Missense_Mutation	SNP	A	A	G			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr2:215279129A>G	uc002vet.2	+	2	342	c.212A>G	c.(211-213)CAT>CGT	p.H71R	VWC2L_uc010zjl.1_Missense_Mutation_p.H71R	NM_001080500	NP_001073969	B2RUY7	VWC2L_HUMAN	von Willebrand factor C domain-containing	71	VWFC 1.					extracellular region					0						TTCCCTGGGCATTCCAACTGT	0.453			NA											7	10					0	0	0.001984	0	0
FN1	2335	broad.mit.edu	37	2	216279643	216279643	+	Missense_Mutation	SNP	G	G	C			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr2:216279643G>C	uc002vfa.2	-	13	2124	c.1858C>G	c.(1858-1860)CCG>GCG	p.P620A	FN1_uc002vfb.2_Missense_Mutation_p.P620A|FN1_uc002vfc.2_Missense_Mutation_p.P620A|FN1_uc002vfd.2_Missense_Mutation_p.P620A|FN1_uc002vfe.2_Missense_Mutation_p.P620A|FN1_uc002vff.2_Missense_Mutation_p.P620A|FN1_uc002vfg.2_Missense_Mutation_p.P620A|FN1_uc002vfh.2_Missense_Mutation_p.P620A|FN1_uc002vfi.2_Missense_Mutation_p.P620A|FN1_uc002vfj.2_Missense_Mutation_p.P620A|FN1_uc002vfl.2_Missense_Mutation_p.P620A	NM_212482	NP_997647	P02751	FINC_HUMAN	fibronectin 1 isoform 1 preproprotein	620	Fibronectin type-III 1.				acute-phase response|angiogenesis|leukocyte migration|peptide cross-linking|platelet activation|platelet degranulation|regulation of cell shape|substrate adhesion-dependent cell spreading	ER-Golgi intermediate compartment|fibrinogen complex|platelet alpha granule lumen|proteinaceous extracellular matrix	collagen binding|extracellular matrix structural constituent|heparin binding			central_nervous_system(7)|large_intestine(2)|breast(2)|ovary(1)|pancreas(1)	13		Renal(323;0.127)		Epithelial(149;9.59e-07)|all cancers(144;0.000174)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)	Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GGCTGACTCGGAGTCTCAGTG	0.443			NA											4	27					0	0	0.009096	0	0
MARCH4	57574	broad.mit.edu	37	2	217234937	217234937	+	Missense_Mutation	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr2:217234937C>T	uc002vgb.2	-	1	1814	c.47G>A	c.(46-48)TGC>TAC	p.C16Y		NM_020814	NP_065865	Q9P2E8	MARH4_HUMAN	membrane-associated ring finger (C3HC4) 4	16						Golgi membrane|Golgi stack|integral to membrane|trans-Golgi network	ubiquitin-protein ligase activity|zinc ion binding			ovary(1)	1		Renal(323;0.0854)		Epithelial(149;2.19e-05)|all cancers(144;0.00121)|LUSC - Lung squamous cell carcinoma(224;0.00902)|Lung(261;0.0125)		CCAGCCGGAGCAGCAGCACCA	0.617			NA											10	15					0	0	0.006214	0	0
TNS1	7145	broad.mit.edu	37	2	218713785	218713785	+	Silent	SNP	T	T	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr2:218713785T>A	uc002vgt.2	-	17	1478	c.1080A>T	c.(1078-1080)CCA>CCT	p.P360P	TNS1_uc002vgr.2_Silent_p.P360P|TNS1_uc002vgs.2_Silent_p.P360P|TNS1_uc010zjv.1_Silent_p.P360P|TNS1_uc010fvj.1_Silent_p.P428P|TNS1_uc010fvk.1_Silent_p.P485P|TNS1_uc010fvi.1_Silent_p.P47P	NM_022648	NP_072174	Q9HBL0	TENS1_HUMAN	tensin	360						cytoplasm|cytoskeleton|focal adhesion	actin binding			ovary(3)|breast(1)	4		Renal(207;0.0483)|Lung NSC(271;0.213)		Epithelial(149;4.43e-06)|all cancers(144;0.000653)|LUSC - Lung squamous cell carcinoma(224;0.0091)|Lung(261;0.013)		TCCCATCTAGTGGCCCCTGCG	0.597			NA											135	141					0	0	0.01441	0	0
CXCR2	3579	broad.mit.edu	37	2	219000386	219000386	+	Missense_Mutation	SNP	C	C	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr2:219000386C>A	uc002vgz.1	+	4	1087	c.862C>A	c.(862-864)CGC>AGC	p.R288S	CXCR2_uc002vha.1_Missense_Mutation_p.R288S|CXCR2_uc002vhb.1_Missense_Mutation_p.R288S	NM_001557	NP_001548	P25025	CXCR2_HUMAN	interleukin 8 receptor beta	288	Extracellular (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|cellular defense response|dendritic cell chemotaxis|inflammatory response|neutrophil activation|neutrophil chemotaxis|positive regulation of cell proliferation	cell surface|integral to plasma membrane|mast cell granule	interleukin-8 receptor activity			lung(1)|breast(1)	2						GACCTGTGAGCGCCGCAATCA	0.592			NA											80	66					1.94393e-27	2.69331e-27	0.01441	1	0
ZNF142	7701	broad.mit.edu	37	2	219507065	219507065	+	Missense_Mutation	SNP	G	G	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr2:219507065G>A	uc002vin.2	-	8	4610	c.4174C>T	c.(4174-4176)CGG>TGG	p.R1392W	ZNF142_uc002vil.2_Missense_Mutation_p.R1353W|ZNF142_uc010fvt.2_Missense_Mutation_p.R1229W|ZNF142_uc002vim.2_Missense_Mutation_p.R1229W	NM_001105537	NP_001099007	P52746	ZN142_HUMAN	zinc finger protein 142	1392	C2H2-type 23.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|ovary(1)|skin(1)	4		Renal(207;0.0474)		Epithelial(149;5.21e-07)|all cancers(144;0.000106)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)		AGGCCCACCCGCTCCCGGGCA	0.637	Colon(170;867 1942 8995 15834 18053)		NA											94	90					0	0	0.01441	0	0
TTLL4	9654	broad.mit.edu	37	2	219617644	219617644	+	Silent	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr2:219617644C>T	uc002viy.2	+	17	3505	c.3135C>T	c.(3133-3135)TTC>TTT	p.F1045F	TTLL4_uc010zkl.1_Silent_p.F880F|TTLL4_uc010fvx.2_Silent_p.F981F|TTLL4_uc010zkm.1_Silent_p.F248F	NM_014640	NP_055455	Q14679	TTLL4_HUMAN	tubulin tyrosine ligase-like family, member 4	1045					protein polyglutamylation	cilium|microtubule basal body	ATP binding|tubulin binding|tubulin-tyrosine ligase activity			ovary(2)|skin(1)	3		Renal(207;0.0915)		Epithelial(149;5.03e-07)|all cancers(144;0.000106)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.0101)		CACGATATTTCAACATTCTCA	0.448	GBM(172;1818 2053 15407 20943 49753)		NA											5	176					0	0	0.001984	0	0
TTLL4	9654	broad.mit.edu	37	2	219617846	219617846	+	Silent	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr2:219617846C>T	uc002viy.2	+	18	3566	c.3196C>T	c.(3196-3198)CTG>TTG	p.L1066L	TTLL4_uc010zkl.1_Silent_p.L901L|TTLL4_uc010fvx.2_Silent_p.L1002L|TTLL4_uc010zkm.1_3'UTR	NM_014640	NP_055455	Q14679	TTLL4_HUMAN	tubulin tyrosine ligase-like family, member 4	1066					protein polyglutamylation	cilium|microtubule basal body	ATP binding|tubulin binding|tubulin-tyrosine ligase activity			ovary(2)|skin(1)	3		Renal(207;0.0915)		Epithelial(149;5.03e-07)|all cancers(144;0.000106)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.0101)		AGGAGTAGATCTGCTCCGGAG	0.498	GBM(172;1818 2053 15407 20943 49753)		NA											8	424					0	0	0.004482	0	0
TTLL4	9654	broad.mit.edu	37	2	219619112	219619112	+	Silent	SNP	A	A	G			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr2:219619112A>G	uc002viy.2	+	20	3970	c.3600A>G	c.(3598-3600)TAA>TAG	p.*1200*	TTLL4_uc010zkl.1_3'UTR|TTLL4_uc010fvx.2_Silent_p.*1136*	NM_014640	NP_055455	Q14679	TTLL4_HUMAN	tubulin tyrosine ligase-like family, member 4	1200					protein polyglutamylation	cilium|microtubule basal body	ATP binding|tubulin binding|tubulin-tyrosine ligase activity			ovary(2)|skin(1)	3		Renal(207;0.0915)		Epithelial(149;5.03e-07)|all cancers(144;0.000106)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.0101)		TGAGCCCATAACTGGCCTCTC	0.552	GBM(172;1818 2053 15407 20943 49753)		NA											5	109					0	0	0.001168	0	0
IHH	3549	broad.mit.edu	37	2	219920102	219920102	+	Missense_Mutation	SNP	G	G	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr2:219920102G>A	uc002vjo.1	-	3	1063	c.1063C>T	c.(1063-1065)CAC>TAC	p.H355Y		NM_002181	NP_002172	Q14623	IHH_HUMAN	Indian hedgehog homolog precursor	355					cell-cell signaling|intein-mediated protein splicing|proteolysis	extracellular space|plasma membrane	cholesterol binding|patched binding|peptidase activity			breast(1)	1		Renal(207;0.0915)		Epithelial(149;1.13e-06)|all cancers(144;0.000188)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		TGAGCCAGGTGGTGGTCAGCC	0.647			NA											33	37					0	0	0.013726	0	0
NHEJ1	79840	broad.mit.edu	37	2	219942919	219942919	+	Missense_Mutation	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr2:219942919C>T	uc002vjp.3	-	6	744	c.598G>A	c.(598-600)GAG>AAG	p.E200K	NHEJ1_uc002vjq.3_RNA	NM_024782	NP_079058	Q9H9Q4	NHEJ1_HUMAN	nonhomologous end-joining factor 1	200					B cell differentiation|central nervous system development|DNA recombination|double-strand break repair via nonhomologous end joining|positive regulation of ligase activity|response to ionizing radiation|T cell differentiation	nonhomologous end joining complex|nucleus	DNA binding|identical protein binding			lung(1)	1		Renal(207;0.0915)		Epithelial(149;2.15e-06)|all cancers(144;0.000339)|LUSC - Lung squamous cell carcinoma(224;0.00902)|Lung(261;0.0112)		CTGCATGCCTCTGGCAGTTTC	0.478			NA						Direct_reversal_of_damage|NHEJ					25	41					0	0	0.003954	0	0
ANKZF1	55139	broad.mit.edu	37	2	220097894	220097894	+	Missense_Mutation	SNP	G	G	C			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr2:220097894G>C	uc002vkg.2	+	6	826	c.652G>C	c.(652-654)GCT>CCT	p.A218P	ANKZF1_uc010zkv.1_Missense_Mutation_p.A162P|ANKZF1_uc010zkw.1_Missense_Mutation_p.A8P|ANKZF1_uc002vkh.2_Missense_Mutation_p.A8P|ANKZF1_uc002vki.2_Missense_Mutation_p.A218P|ANKZF1_uc002vkj.1_Missense_Mutation_p.A206P	NM_018089	NP_060559	Q9H8Y5	ANKZ1_HUMAN	ankyrin repeat and zinc finger domain containing	218						intracellular	zinc ion binding			ovary(2)	2		Renal(207;0.0474)		Epithelial(149;1.2e-06)|all cancers(144;0.000197)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		TGGGCACTTTGCTGGTGCTAT	0.557			NA											95	234					0	0	0.01441	0	0
STK11IP	114790	broad.mit.edu	37	2	220473349	220473349	+	Nonsense_Mutation	SNP	G	G	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr2:220473349G>T	uc002vml.2	+	15	1724	c.1681G>T	c.(1681-1683)GAG>TAG	p.E561*	STK11IP_uc010zll.1_Nonsense_Mutation_p.E518*|STK11IP_uc002vmm.1_Nonsense_Mutation_p.E550*	NM_052902	NP_443134	Q8N1F8	S11IP_HUMAN	LKB1 interacting protein	561	Glu-rich.				protein localization	cytoplasm	protein kinase binding			ovary(1)	1		Renal(207;0.0183)		Epithelial(149;2.69e-07)|all cancers(144;5.91e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GGAGGGGCCTGAGGGCGTACG	0.607			NA											11	81					1.49906e-05	1.65776e-05	0.00245	1	0
PAX3	5077	broad.mit.edu	37	2	223084905	223084905	+	Missense_Mutation	SNP	G	G	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr2:223084905G>T	uc010fwo.2	-	7	1493	c.1127C>A	c.(1126-1128)CCC>CAC	p.P376H	PAX3_uc002vmt.1_Missense_Mutation_p.P376H|PAX3_uc002vmy.1_Missense_Mutation_p.P375H|PAX3_uc002vmv.1_Missense_Mutation_p.P376H|PAX3_uc002vmw.1_Missense_Mutation_p.P376H|PAX3_uc002vmx.1_Missense_Mutation_p.P376H	NM_181457	NP_852122	P23760	PAX3_HUMAN	paired box 3 isoform PAX3	376					apoptosis|organ morphogenesis|positive regulation of transcription from RNA polymerase II promoter|sensory perception of sound|transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		PAX3/FOXO1(749)|PAX3/NCOA1(8)|PAX3/NCOA2(4)	soft_tissue(761)|ovary(4)|skin(1)	766		Renal(207;0.0183)		Epithelial(121;4.13e-10)|all cancers(144;1.85e-07)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GGGGTTGGAGGGCCCCGACGG	0.542			NA	T	FOXO1A|NCOA1	alveolar rhabdomyosarcoma		Waardenburg syndrome; craniofacial-deafness-hand syndrome						7	39					2.0095e-06	2.28488e-06	0.001984	1	0
KIAA1486	57624	broad.mit.edu	37	2	226273676	226273676	+	Missense_Mutation	SNP	G	G	C			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr2:226273676G>C	uc002voe.2	+	2	255	c.80G>C	c.(79-81)GGG>GCG	p.G27A	KIAA1486_uc010fxa.1_Missense_Mutation_p.G22A	NM_020864	NP_065915	Q9P242	K1486_HUMAN	hypothetical protein LOC57624	27										ovary(2)|central_nervous_system(1)	3		Renal(207;0.0112)|all_lung(227;0.0477)|Lung NSC(271;0.0644)|all_hematologic(139;0.101)|Esophageal squamous(248;0.129)		Epithelial(121;6.73e-10)|all cancers(144;4.32e-07)|Lung(261;0.0161)|LUSC - Lung squamous cell carcinoma(224;0.0223)		GAGGATATGGGGATGAAGGCC	0.428			NA											14	18					0	0	0.003163	0	0
IRS1	3667	broad.mit.edu	37	2	227661262	227661262	+	Missense_Mutation	SNP	G	G	C			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr2:227661262G>C	uc002voh.3	-	1	2245	c.2193C>G	c.(2191-2193)GAC>GAG	p.D731E		NM_005544	NP_005535	P35568	IRS1_HUMAN	insulin receptor substrate 1	731					fibroblast growth factor receptor signaling pathway|glucose homeostasis|insulin receptor signaling pathway|negative regulation of insulin receptor signaling pathway|negative regulation of insulin secretion|nerve growth factor receptor signaling pathway|phosphatidylinositol 3-kinase cascade|phosphatidylinositol-mediated signaling|positive regulation of fatty acid beta-oxidation|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of insulin receptor signaling pathway|positive regulation of phosphatidylinositol 3-kinase activity	caveola|cytosol|insulin receptor complex|microsome|nucleus	insulin receptor binding|insulin-like growth factor receptor binding|phosphatidylinositol 3-kinase binding|protein kinase C binding|SH2 domain binding|transmembrane receptor protein tyrosine kinase adaptor activity			lung(5)|central_nervous_system(4)|ovary(2)|pancreas(1)	12		Renal(207;0.023)|all_lung(227;0.0994)|all_hematologic(139;0.118)|Esophageal squamous(248;0.23)		Epithelial(121;3.03e-11)|all cancers(144;2.42e-08)|Lung(261;0.00712)|LUSC - Lung squamous cell carcinoma(224;0.0137)		TGTTCATGTAGTCACCTGTGC	0.597			NA									OREG0015248	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	13	311					0	0	0.013537	0	0
C2orf83	56918	broad.mit.edu	37	2	228497784	228497784	+	Silent	SNP	C	C	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr2:228497784C>A	uc002vph.2	-	1	253	c.18G>T	c.(16-18)CTG>CTT	p.L6L	C2orf83_uc010zlu.1_Silent_p.L6L	NM_020161	NP_064546	Q53S99	CB083_HUMAN	hypothetical protein LOC56918 isoform 1	6						membrane	folic acid binding|reduced folate carrier activity				0						TTCCAAACGTCAGGGCATAGT	0.428			NA											13	17					0.000219431	0.000235836	0.00245	1	0
PID1	55022	broad.mit.edu	37	2	230020567	230020567	+	Silent	SNP	C	C	G			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr2:230020567C>G	uc002vpr.3	-	2	281	c.243G>C	c.(241-243)CCG>CCC	p.P81P	PID1_uc002vps.3_Silent_p.P79P|PID1_uc002vpt.3_Silent_p.P48P|PID1_uc002vpu.3_Intron	NM_001100818	NP_001094288	Q7Z2X4	PCLI1_HUMAN	phosphotyrosine interaction domain containing 1	81						cytoplasm				breast(3)|skin(1)	4		Renal(207;0.0112)|all_lung(227;0.0191)|Lung NSC(271;0.0851)|all_hematologic(139;0.104)|Acute lymphoblastic leukemia(138;0.171)		Epithelial(121;3.08e-11)|all cancers(144;2.28e-08)|LUSC - Lung squamous cell carcinoma(224;0.0145)|Lung(261;0.0189)		TCTTCATCAGCGGTGTGGTCG	0.527			NA											33	64					0	0	0.009535	0	0
DIS3L2	129563	broad.mit.edu	37	2	232894773	232894773	+	Missense_Mutation	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr2:232894773C>T	uc010fxz.2	+	5	625	c.349C>T	c.(349-351)CCC>TCC	p.P117S	DIS3L2_uc002vsm.3_RNA|DIS3L2_uc002vsn.1_Missense_Mutation_p.P117S|DIS3L2_uc002vso.2_RNA	NM_152383	NP_689596	Q8IYB7	DI3L2_HUMAN	DIS3 mitotic control homolog (S.	117							exonuclease activity|ribonuclease activity|RNA binding			ovary(1)|breast(1)|central_nervous_system(1)	3		all_hematologic(139;0.00809)|Renal(207;0.0113)|Acute lymphoblastic leukemia(138;0.0195)|all_lung(227;0.0465)|Lung NSC(271;0.136)		Epithelial(121;1.6e-13)|BRCA - Breast invasive adenocarcinoma(100;0.00104)|LUSC - Lung squamous cell carcinoma(224;0.0109)|Lung(119;0.0149)		GAAACTGCTTCCCGAGGAGCA	0.428			NA											26	21					0	0	0.00333	0	0
SH3BP4	23677	broad.mit.edu	37	2	235949751	235949751	+	Missense_Mutation	SNP	A	A	G			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr2:235949751A>G	uc002vvp.2	+	4	731	c.338A>G	c.(337-339)AAC>AGC	p.N113S	SH3BP4_uc010fym.2_Missense_Mutation_p.N113S|SH3BP4_uc002vvq.2_Missense_Mutation_p.N113S	NM_014521	NP_055336	Q9P0V3	SH3B4_HUMAN	SH3-domain binding protein 4	113	SH3.				endocytosis	clathrin-coated vesicle|coated pit|nucleus	protein binding			skin(3)|ovary(1)	4		Breast(86;0.000332)|Renal(207;0.00339)|all_lung(227;0.00458)|all_hematologic(139;0.0296)|Lung NSC(271;0.0419)		Epithelial(121;7.66e-20)|BRCA - Breast invasive adenocarcinoma(100;0.000402)|Lung(119;0.00299)|LUSC - Lung squamous cell carcinoma(224;0.00645)|GBM - Glioblastoma multiforme(43;0.237)		CAGCCCTTGAACTACCGGAAC	0.552			NA											8	36					0	0	0.00308	0	0
SH3BP4	23677	broad.mit.edu	37	2	235962399	235962399	+	Missense_Mutation	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr2:235962399C>T	uc002vvp.2	+	6	3224	c.2831C>T	c.(2830-2832)TCC>TTC	p.S944F	SH3BP4_uc010fym.2_Missense_Mutation_p.S926F|SH3BP4_uc002vvq.2_Missense_Mutation_p.S944F	NM_014521	NP_055336	Q9P0V3	SH3B4_HUMAN	SH3-domain binding protein 4	944					endocytosis	clathrin-coated vesicle|coated pit|nucleus	protein binding			skin(3)|ovary(1)	4		Breast(86;0.000332)|Renal(207;0.00339)|all_lung(227;0.00458)|all_hematologic(139;0.0296)|Lung NSC(271;0.0419)		Epithelial(121;7.66e-20)|BRCA - Breast invasive adenocarcinoma(100;0.000402)|Lung(119;0.00299)|LUSC - Lung squamous cell carcinoma(224;0.00645)|GBM - Glioblastoma multiforme(43;0.237)		TTGGTGAACTCCCTGGACGTT	0.597			NA											14	119					0	0	0.001855	0	0
SCLY	51540	broad.mit.edu	37	2	239006934	239006934	+	Missense_Mutation	SNP	G	G	C			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr2:239006934G>C	uc010fyv.2	+	12	1340	c.1276G>C	c.(1276-1278)GAG>CAG	p.E426Q	SCLY_uc002vxm.3_Missense_Mutation_p.E393Q|SCLY_uc010znq.1_Missense_Mutation_p.E220Q|SCLY_uc010znr.1_Missense_Mutation_p.E332Q|SCLY_uc002vxp.3_RNA|ESPNL_uc002vxq.3_5'Flank	NM_016510	NP_057594	Q96I15	SCLY_HUMAN	selenocysteine lyase	426					cellular amino acid metabolic process	cytosol	pyridoxal phosphate binding|selenocysteine lyase activity|transferase activity			ovary(2)	2		Breast(86;7.61e-05)|Renal(207;0.00183)|Ovarian(221;0.0481)|all_hematologic(139;0.158)|all_lung(227;0.198)|Melanoma(123;0.203)|Hepatocellular(293;0.244)		Epithelial(121;1.37e-23)|OV - Ovarian serous cystadenocarcinoma(60;4.6e-12)|Kidney(56;3.21e-09)|KIRC - Kidney renal clear cell carcinoma(57;8.25e-08)|BRCA - Breast invasive adenocarcinoma(100;0.000128)|Lung(119;0.0118)|LUSC - Lung squamous cell carcinoma(224;0.0285)		CACCAGGGCCGAGGTGGACCT	0.716	Melanoma(24;424 891 11947 32582 36034)|Ovarian(46;648 1065 26199 32764 45893)		NA											17	18					0	0	0.004007	0	0
KLHL30	377007	broad.mit.edu	37	2	239059471	239059471	+	Missense_Mutation	SNP	G	G	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr2:239059471G>A	uc002vxr.1	+	7	1481	c.1448G>A	c.(1447-1449)AGC>AAC	p.S483N		NM_198582	NP_940984	Q0D2K2	KLH30_HUMAN	kelch-like 30	501	Kelch 5.										0		Breast(86;7.61e-05)|Renal(207;0.00183)|Ovarian(221;0.0481)|all_hematologic(139;0.158)|all_lung(227;0.198)|Melanoma(123;0.203)|Hepatocellular(293;0.244)		Epithelial(121;4.71e-24)|OV - Ovarian serous cystadenocarcinoma(60;3.02e-12)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;5.63e-08)|BRCA - Breast invasive adenocarcinoma(100;0.000109)|Lung(119;0.0108)|LUSC - Lung squamous cell carcinoma(224;0.0253)		TCACAGCACAGCCTGCATGAG	0.672			NA											4	3					0	0	0.009096	0	0
ANKMY1	51281	broad.mit.edu	37	2	241439489	241439489	+	Nonsense_Mutation	SNP	C	C	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr2:241439489C>A	uc002vyz.1	-	14	2654	c.2425G>T	c.(2425-2427)GAG>TAG	p.E809*	ANKMY1_uc002vza.1_Nonsense_Mutation_p.E585*|ANKMY1_uc010fzd.1_Nonsense_Mutation_p.E898*|ANKMY1_uc002vzb.1_Nonsense_Mutation_p.E570*|ANKMY1_uc002vzc.1_Nonsense_Mutation_p.E588*|ANKMY1_uc002vzd.1_Nonsense_Mutation_p.E632*	NM_016552	NP_057636	Q9P2S6	ANKY1_HUMAN	ankyrin repeat and MYND domain containing 1	809							zinc ion binding			central_nervous_system(1)	1		all_epithelial(40;2.79e-15)|Breast(86;2.41e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0335)|Lung NSC(271;0.106)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;1.03e-30)|all cancers(36;4.78e-28)|OV - Ovarian serous cystadenocarcinoma(60;1.45e-14)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;7.8e-06)|Lung(119;0.00271)|LUSC - Lung squamous cell carcinoma(224;0.01)|Colorectal(34;0.0101)|COAD - Colon adenocarcinoma(134;0.0476)		AGGAACGTCTCGCGCTCTGCT	0.677			NA											13	16					2.27111e-07	2.64023e-07	0.013537	1	0
DUSP28	285193	broad.mit.edu	37	2	241500167	241500167	+	Silent	SNP	C	C	G			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr2:241500167C>G	uc002vzg.2	+	1	697	c.66C>G	c.(64-66)GTC>GTG	p.V22V	ANKMY1_uc002vyz.1_5'Flank|ANKMY1_uc002vza.1_5'Flank|ANKMY1_uc010fzd.1_5'Flank|ANKMY1_uc002vzb.1_5'Flank|ANKMY1_uc002vzc.1_5'Flank|ANKMY1_uc002vzd.1_5'UTR|ANKMY1_uc010fze.1_5'UTR|ANKMY1_uc002vze.2_5'UTR|ANKMY1_uc002vzf.2_5'UTR|DUSP28_uc002vzh.2_Silent_p.V22V	NM_001033575	NP_001028747	Q4G0W2	DUS28_HUMAN	dual specificity phosphatase 28	22							protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			upper_aerodigestive_tract(1)	1		all_epithelial(40;2.79e-15)|Breast(86;2.41e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0335)|Lung NSC(271;0.106)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;2.16e-31)|all cancers(36;5.56e-29)|OV - Ovarian serous cystadenocarcinoma(60;7.57e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;5.06e-06)|Lung(119;0.00164)|Colorectal(34;0.00468)|LUSC - Lung squamous cell carcinoma(224;0.00802)|COAD - Colon adenocarcinoma(134;0.0311)		TGGTGCGCGTCGCGCCCTCAC	0.736	Pancreas(150;1630 2604 23402 46829)		NA											4	5					0	0	0.000602	0	0
DUSP28	285193	broad.mit.edu	37	2	241500430	241500430	+	Missense_Mutation	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr2:241500430C>T	uc002vzg.2	+	1	960	c.329C>T	c.(328-330)TCG>TTG	p.S110L	ANKMY1_uc002vzd.1_5'Flank|ANKMY1_uc010fze.1_5'Flank|ANKMY1_uc002vze.2_5'Flank|ANKMY1_uc002vzf.2_5'Flank|DUSP28_uc002vzh.2_Missense_Mutation_p.S110L	NM_001033575	NP_001028747	Q4G0W2	DUS28_HUMAN	dual specificity phosphatase 28	110	Tyrosine-protein phosphatase.						protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			upper_aerodigestive_tract(1)	1		all_epithelial(40;2.79e-15)|Breast(86;2.41e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0335)|Lung NSC(271;0.106)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;2.16e-31)|all cancers(36;5.56e-29)|OV - Ovarian serous cystadenocarcinoma(60;7.57e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;5.06e-06)|Lung(119;0.00164)|Colorectal(34;0.00468)|LUSC - Lung squamous cell carcinoma(224;0.00802)|COAD - Colon adenocarcinoma(134;0.0311)		CGCAGCCGCTCGGCCGCCGTC	0.736	Pancreas(150;1630 2604 23402 46829)		NA											3	2					0	0	0.009096	0	0
C20orf194	25943	broad.mit.edu	37	20	3262307	3262307	+	Missense_Mutation	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr20:3262307C>T	uc002wii.2	-	28	2643	c.2592G>A	c.(2590-2592)ATG>ATA	p.M864I	C20orf194_uc002wij.3_Missense_Mutation_p.M603I|C20orf194_uc002wik.2_Missense_Mutation_p.M538I	NM_001009984	NP_001009984	Q5TEA3	CT194_HUMAN	hypothetical protein LOC25943	864											0						TGTAGCAGCTCATGGGCTCCA	0.483			NA											9	65					0	0	0.004482	0	0
ATRN	8455	broad.mit.edu	37	20	3541497	3541497	+	Missense_Mutation	SNP	C	C	G			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr20:3541497C>G	uc002wim.2	+	8	1482	c.1392C>G	c.(1390-1392)ATC>ATG	p.I464M	ATRN_uc002wil.2_Missense_Mutation_p.I464M	NM_139321	NP_647537	O75882	ATRN_HUMAN	attractin isoform 1	464	Extracellular (Potential).|Kelch 3.				inflammatory response	extracellular space|integral to plasma membrane	receptor activity|sugar binding			ovary(1)|breast(1)	2						TGCTGGTCATCTTTGGTCACT	0.443			NA											13	48					0	0	0.013537	0	0
PRNP	5621	broad.mit.edu	37	20	4680383	4680383	+	Missense_Mutation	SNP	A	A	C			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr20:4680383A>C	uc002wku.2	+	2	880	c.517A>C	c.(517-519)AAC>CAC	p.N173H	PRNP_uc002wkv.2_Missense_Mutation_p.N173H|PRNP_uc002wkw.2_Missense_Mutation_p.N173H|PRNP_uc002wkx.2_Missense_Mutation_p.N173H|PRNP_uc002wkt.1_Missense_Mutation_p.N143H|PRNP_uc002wky.2_Missense_Mutation_p.N173H|PRNP_uc010gbe.1_Missense_Mutation_p.N173H	NM_001080122	NP_001073591	P04156	PRIO_HUMAN	prion protein preproprotein	173	Interaction with GRB2, ERI3 and SYN1 (By similarity).				axon guidance|cell cycle arrest|cellular copper ion homeostasis|metabolic process|negative regulation of activated T cell proliferation|negative regulation of calcineurin-NFAT signaling pathway|negative regulation of interferon-gamma production|negative regulation of interleukin-17 production|negative regulation of interleukin-2 production|negative regulation of protein phosphorylation|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of T cell receptor signaling pathway|protein homooligomerization|response to oxidative stress	anchored to membrane|endoplasmic reticulum|extrinsic to membrane|Golgi apparatus|membrane raft|nucleus|plasma membrane	copper ion binding|identical protein binding|microtubule binding			central_nervous_system(1)	1					Tetracycline(DB00759)	CAGCAACCAGAACAACTTTGT	0.493			NA											10	52					0	0	0.006214	0	0
PLCB1	23236	broad.mit.edu	37	20	8745806	8745806	+	Missense_Mutation	SNP	G	G	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr20:8745806G>A	uc002wnb.2	+	26	2734	c.2731G>A	c.(2731-2733)GAA>AAA	p.E911K	PLCB1_uc010zrb.1_Missense_Mutation_p.E810K|PLCB1_uc002wna.2_Missense_Mutation_p.E911K|PLCB1_uc002wnc.1_Missense_Mutation_p.E810K|PLCB1_uc002wnd.1_Missense_Mutation_p.E488K	NM_015192	NP_056007	Q9NQ66	PLCB1_HUMAN	phosphoinositide-specific phospholipase C beta 1	911					activation of meiosis involved in egg activation|CD24 biosynthetic process|cerebral cortex development|G1 phase|G2/M transition of mitotic cell cycle|glutamate signaling pathway|insulin-like growth factor receptor signaling pathway|interleukin-1-mediated signaling pathway|interleukin-12-mediated signaling pathway|interleukin-15-mediated signaling pathway|intracellular signal transduction|lipid catabolic process|memory|muscarinic acetylcholine receptor signaling pathway|negative regulation of monocyte extravasation|negative regulation of transcription, DNA-dependent|phosphatidylinositol metabolic process|positive regulation of acrosome reaction|positive regulation of developmental growth|positive regulation of embryonic development|positive regulation of interleukin-12 production|positive regulation of JNK cascade|positive regulation of myoblast differentiation|positive regulation of transcription, DNA-dependent|regulation of fertilization|regulation of G-protein coupled receptor protein signaling pathway|synaptic transmission	cytosol|nuclear chromatin|nuclear speck	calcium ion binding|calmodulin binding|enzyme binding|GTPase activator activity|phosphatidylinositol phospholipase C activity|phosphatidylinositol-4,5-bisphosphate binding|protein homodimerization activity|signal transducer activity			ovary(4)|breast(3)|upper_aerodigestive_tract(2)|skin(2)|lung(1)	12						ACAGACCATCGAAGAACTAAA	0.418			NA											7	29					0	0	0.00308	0	0
C20orf103	24141	broad.mit.edu	37	20	9498764	9498764	+	Missense_Mutation	SNP	C	C	G			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr20:9498764C>G	uc002wni.1	+	5	782	c.553C>G	c.(553-555)CAA>GAA	p.Q185E	C20orf103_uc010zrc.1_Missense_Mutation_p.Q141E	NM_012261	NP_036393	Q9UJQ1	CT103_HUMAN	chromosome 20 open reading frame 103 precursor	185	Extracellular (Potential).					integral to membrane				upper_aerodigestive_tract(1)|lung(1)|breast(1)	3			COAD - Colon adenocarcinoma(9;0.194)			GTGTCAAGCTCAACAAACCAT	0.522			NA											8	71					0	0	0.004482	0	0
SNAP25	6616	broad.mit.edu	37	20	10286806	10286806	+	Missense_Mutation	SNP	G	G	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr20:10286806G>T	uc002wnq.1	+	8	794	c.582G>T	c.(580-582)GAG>GAT	p.E194D	SNAP25_uc002wnr.1_Missense_Mutation_p.E194D|SNAP25_uc002wns.1_Missense_Mutation_p.E131D|SNAP25_uc010gca.1_Missense_Mutation_p.E194D|SNAP25_uc010gcb.1_Missense_Mutation_p.E131D|SNAP25_uc010gcc.1_Missense_Mutation_p.E88D	NM_130811	NP_570824	P60880	SNP25_HUMAN	synaptosomal-associated protein 25 isoform	194	t-SNARE coiled-coil homology 2.				energy reserve metabolic process|glutamate secretion|neurotransmitter uptake|synaptic vesicle docking involved in exocytosis	cell junction|growth cone|perinuclear region of cytoplasm|synapse|synaptosome				skin(2)	2					Botulinum Toxin Type A(DB00083)	GAATTGATGAGGCCAACCAAC	0.483			NA											8	28					0.000442599	0.000469777	0.006214	1	0
KIF16B	55614	broad.mit.edu	37	20	16359917	16359917	+	Silent	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr20:16359917C>T	uc002wpg.1	-	19	2888	c.2730G>A	c.(2728-2730)CAG>CAA	p.Q910Q	KIF16B_uc002wpe.1_Silent_p.Q292Q|KIF16B_uc002wpf.1_Silent_p.Q292Q|KIF16B_uc010gch.1_Silent_p.Q910Q|KIF16B_uc010gci.1_Silent_p.Q910Q|KIF16B_uc010gcj.1_Silent_p.Q921Q	NM_024704	NP_078980	Q96L93	KI16B_HUMAN	kinesin-like motor protein C20orf23	910	Glu-rich.				cell communication|early endosome to late endosome transport|endoderm development|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|formation of primary germ layer|Golgi to endosome transport|microtubule-based movement|receptor catabolic process|regulation of receptor recycling	early endosome membrane|microtubule	ATP binding|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding|plus-end-directed microtubule motor activity			skin(2)|large_intestine(1)|central_nervous_system(1)|lung(1)|breast(1)|ovary(1)|kidney(1)	8						GCAGGAGGTACTGTAGCTGGC	0.443			NA											48	70					0	0	0.013114	0	0
BFSP1	631	broad.mit.edu	37	20	17475142	17475142	+	Missense_Mutation	SNP	C	C	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr20:17475142C>A	uc002wpo.2	-	8	1614	c.1575G>T	c.(1573-1575)CAG>CAT	p.Q525H	BFSP1_uc002wpp.2_Missense_Mutation_p.Q400H|BFSP1_uc010zrn.1_Missense_Mutation_p.Q386H|BFSP1_uc010zro.1_Missense_Mutation_p.Q386H	NM_001195	NP_001186	Q12934	BFSP1_HUMAN	filensin isoform 1	525	Tail.					cytoplasm|intermediate filament|membrane	structural constituent of cytoskeleton|structural constituent of eye lens			central_nervous_system(1)	1						GCAGACCCACCTGCCCATTCT	0.547			NA											31	58					7.26314e-15	9.48389e-15	0.007291	1	0
RIN2	54453	broad.mit.edu	37	20	19955398	19955398	+	Silent	SNP	C	C	G			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr20:19955398C>G	uc002wro.1	+	7	765	c.729C>G	c.(727-729)CTC>CTG	p.L243L	RIN2_uc010gcu.1_Intron|RIN2_uc010gcv.1_Silent_p.L37L	NM_018993	NP_061866	Q8WYP3	RIN2_HUMAN	Ras and Rab interactor 2	243					endocytosis|small GTPase mediated signal transduction	cytoplasm	GTPase activator activity|Rab guanyl-nucleotide exchange factor activity			lung(4)|ovary(1)	5						TGCGTCAGCTCTGCCTTATAA	0.552			NA											7	80					0	0	0.001984	0	0
CRNKL1	51340	broad.mit.edu	37	20	20025969	20025969	+	Missense_Mutation	SNP	C	C	G			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr20:20025969C>G	uc002wrs.2	-	7	1299	c.1267G>C	c.(1267-1269)GAA>CAA	p.E423Q		NM_016652	NP_057736	Q9BZJ0	CRNL1_HUMAN	crooked neck-like 1 protein	423	HAT 6.				spliceosome assembly	catalytic step 2 spliceosome|cytoplasm|nuclear speck	RNA binding			ovary(2)|large_intestine(1)	3						TGATTTTCTTCAAACTTGGCA	0.363			NA											16	89					0	0	0.004007	0	0
XRN2	22803	broad.mit.edu	37	20	21346252	21346252	+	Missense_Mutation	SNP	C	C	G			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr20:21346252C>G	uc002wsf.1	+	26	2461	c.2366C>G	c.(2365-2367)TCC>TGC	p.S789C	XRN2_uc002wsg.1_Missense_Mutation_p.S713C|XRN2_uc010zsk.1_Missense_Mutation_p.S735C	NM_012255	NP_036387	Q9H0D6	XRN2_HUMAN	5'-3' exoribonuclease 2	789					cell growth|DNA catabolic process, exonucleolytic|mRNA processing|regulation of transcription, DNA-dependent|RNA catabolic process|spermatogenesis|transcription termination, DNA-dependent	nucleolus	5'-3' exoribonuclease activity|nucleic acid binding|protein binding|zinc ion binding			skin(1)	1						TGGGAAAAATCCAGCAATGGA	0.473			NA											20	100					0	0	0.008871	0	0
COX4I2	84701	broad.mit.edu	37	20	30232608	30232608	+	Silent	SNP	G	G	C			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr20:30232608G>C	uc002wwj.1	+	5	492	c.417G>C	c.(415-417)CGG>CGC	p.R139R		NM_032609	NP_115998	Q96KJ9	COX42_HUMAN	cytochrome c oxidase subunit IV isoform 2	139					cellular respiration		cytochrome-c oxidase activity			ovary(1)	1	all_cancers(5;7.12e-06)|Lung NSC(7;3.95e-06)|all_epithelial(3;4.36e-06)|all_lung(7;6.68e-06)|all_hematologic(12;0.158)|Ovarian(7;0.198)		Epithelial(4;1.01e-05)|all cancers(5;9.46e-05)|OV - Ovarian serous cystadenocarcinoma(3;0.00121)|Colorectal(19;0.0055)|COAD - Colon adenocarcinoma(19;0.0264)			CGGACGAGCGGAAAGCCCAGC	0.582			NA											11	47					0	0	0.010729	0	0
HCK	3055	broad.mit.edu	37	20	30667605	30667605	+	Missense_Mutation	SNP	G	G	C			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr20:30667605G>C	uc002wxh.2	+	6	628	c.457G>C	c.(457-459)GAC>CAC	p.D153H	HCK_uc010gdy.2_Missense_Mutation_p.D132H|HCK_uc002wxi.2_Missense_Mutation_p.D131H	NM_002110	NP_002101	P08631	HCK_HUMAN	hemopoietic cell kinase isoform p61HCK	153	SH2.				interspecies interaction between organisms|mesoderm development|regulation of defense response to virus by virus|viral reproduction	caveola|cytosol	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding			lung(4)|ovary(2)|central_nervous_system(2)|pancreas(1)	9			UCEC - Uterine corpus endometrioid carcinoma (5;0.0241)			CAGCCGGAAGGACGCAGAGCG	0.587			NA											10	26					0	0	0.010729	0	0
PLAGL2	5326	broad.mit.edu	37	20	30784777	30784777	+	Missense_Mutation	SNP	C	C	G			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr20:30784777C>G	uc002wxn.2	-	3	1186	c.969G>C	c.(967-969)ATG>ATC	p.M323I		NM_002657	NP_002648	Q9UPG8	PLAL2_HUMAN	pleiomorphic adenoma gene-like 2	323						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|skin(1)	2			UCEC - Uterine corpus endometrioid carcinoma (5;0.0241)			GAGGGTAGCTCATACCCATGG	0.567	Colon(163;15 1893 11280 16306 47518)		NA											41	161					0	0	0.007835	0	0
ASXL1	171023	broad.mit.edu	37	20	31016158	31016158	+	Missense_Mutation	SNP	C	C	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr20:31016158C>A	uc002wxs.2	+	5	830	c.404C>A	c.(403-405)TCC>TAC	p.S135Y	ASXL1_uc002wxr.1_RNA|ASXL1_uc010geb.2_Missense_Mutation_p.S77Y	NM_015338	NP_056153	Q8IXJ9	ASXL1_HUMAN	additional sex combs like 1 isoform 1	135					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	PR-DUB complex	metal ion binding|protein binding			haematopoietic_and_lymphoid_tissue(239)|large_intestine(6)|central_nervous_system(2)|ovary(1)	248						TCGAACGCATCCTGTTCTACA	0.493			NA	F|N|Mis		MDS|CMML								29	126					7.01153e-11	8.67924e-11	0.007291	1	0
NECAB3	63941	broad.mit.edu	37	20	32248157	32248157	+	Missense_Mutation	SNP	G	G	C			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr20:32248157G>C	uc002wzn.3	-	6	538	c.432C>G	c.(430-432)TTC>TTG	p.F144L	NECAB3_uc002wzl.2_5'UTR|NECAB3_uc002wzm.3_Missense_Mutation_p.F144L|NECAB3_uc002wzo.3_RNA|NECAB3_uc002wzp.3_Missense_Mutation_p.F95L|NECAB3_uc002wzq.3_Missense_Mutation_p.F144L|NECAB3_uc002wzr.3_RNA|NECAB3_uc010geo.2_Missense_Mutation_p.F144L|C20orf144_uc002wzs.1_5'Flank	NM_031232	NP_112509	Q96P71	NECA3_HUMAN	N-terminal EF-hand calcium binding protein 3	144					antibiotic biosynthetic process|protein metabolic process|protein secretion|regulation of amyloid precursor protein biosynthetic process	endoplasmic reticulum membrane|Golgi cis cisterna|nucleus	calcium ion binding|oxidoreductase activity|protein binding			lung(1)	1						CCCGCAGCAGGAAGCGCGTCA	0.637			NA											9	90					0	0	0.004482	0	0
CHMP4B	128866	broad.mit.edu	37	20	32436305	32436305	+	Missense_Mutation	SNP	T	T	C			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr20:32436305T>C	uc002xaa.2	+	2	379	c.223T>C	c.(223-225)TAT>CAT	p.Y75H		NM_176812	NP_789782	Q9H444	CHM4B_HUMAN	chromatin modifying protein 4B	75	Potential.				cellular membrane organization|endosome transport|protein transport	cytosol|late endosome membrane	protein binding			ovary(1)|central_nervous_system(1)	2						TAAGAAGAGGTATGAGAAGCA	0.567			NA											10	48					0	0	0.008291	0	0
ASIP	434	broad.mit.edu	37	20	32848288	32848288	+	Silent	SNP	G	G	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr20:32848288G>A	uc002xah.1	+	1	118	c.108G>A	c.(106-108)CTG>CTA	p.L36L		NM_001672	NP_001663	P42127	ASIP_HUMAN	agouti signaling protein precursor	36					cell-cell signaling|generation of precursor metabolites and energy|hormone-mediated signaling pathway	extracellular space				central_nervous_system(1)	1						ACAGGAGCCTGAGAAGCAACT	0.582			NA											16	116					0	0	0.00499	0	0
NCOA6	23054	broad.mit.edu	37	20	33328826	33328826	+	Missense_Mutation	SNP	G	G	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr20:33328826G>A	uc002xav.2	-	12	7805	c.5234C>T	c.(5233-5235)TCC>TTC	p.S1745F	NCOA6_uc002xaw.2_Missense_Mutation_p.S1745F	NM_014071	NP_054790	Q14686	NCOA6_HUMAN	nuclear receptor coactivator 6	1745	EP300/CRSP3-binding region.				brain development|cellular lipid metabolic process|DNA recombination|DNA repair|DNA replication|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|heart development|myeloid cell differentiation|positive regulation of transcription from RNA polymerase II promoter|response to hormone stimulus|transcription initiation from RNA polymerase II promoter	transcription factor complex	chromatin binding|enzyme binding|estrogen receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|retinoid X receptor binding|thyroid hormone receptor binding			ovary(3)|breast(3)|central_nervous_system(1)	7						ACAAGGAGGGGAAGGAAGCTG	0.542			NA											19	38					0	0	0.007413	0	0
FAM83C	128876	broad.mit.edu	37	20	33875629	33875629	+	Missense_Mutation	SNP	G	G	C			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr20:33875629G>C	uc010zux.1	-	4	1071	c.953C>G	c.(952-954)TCT>TGT	p.S318C	FAM83C_uc002xcb.1_Intron	NM_178468	NP_848563	Q9BQN1	FA83C_HUMAN	hypothetical protein LOC128876	318										ovary(2)	2			BRCA - Breast invasive adenocarcinoma(18;0.00252)			TGCCCGGGGAGACAGCGGGTC	0.667			NA											5	19					0	0	0.000602	0	0
RBM39	9584	broad.mit.edu	37	20	34295058	34295058	+	Missense_Mutation	SNP	T	T	C			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr20:34295058T>C	uc002xeb.2	-	14	1635	c.1291A>G	c.(1291-1293)ATG>GTG	p.M431V	RBM39_uc002xdz.2_Missense_Mutation_p.M407V|RBM39_uc002xea.2_Missense_Mutation_p.M274V|RBM39_uc010gfn.2_Missense_Mutation_p.M274V|RBM39_uc010zvm.1_Missense_Mutation_p.M403V|RBM39_uc002xeg.2_Missense_Mutation_p.M409V|RBM39_uc002xec.2_Missense_Mutation_p.M425V|RBM39_uc002xed.2_Missense_Mutation_p.M149V|RBM39_uc002xee.2_Missense_Mutation_p.M274V|RBM39_uc002xef.2_Missense_Mutation_p.M268V|RBM39_uc010zvn.1_Missense_Mutation_p.M274V	NM_184234	NP_909122	Q14498	RBM39_HUMAN	RNA binding motif protein 39 isoform a	431	Interaction with NCOA6 (By similarity).				mRNA processing|regulation of transcription, DNA-dependent|RNA splicing|transcription, DNA-dependent	centrosome|nuclear speck	nucleotide binding|protein binding|RNA binding			ovary(1)|central_nervous_system(1)	2	all_epithelial(2;0.00295)|Lung NSC(9;0.00453)|Breast(12;0.00544)|all_lung(11;0.00676)					GGGTTAAACATGTTAGAGAGT	0.313			NA											6	13					0	0	0.001168	0	0
RPRD1B	58490	broad.mit.edu	37	20	36694555	36694555	+	Missense_Mutation	SNP	G	G	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr20:36694555G>T	uc002xho.3	+	6	1130	c.728G>T	c.(727-729)CGC>CTC	p.R243L	RPRD1B_uc002xhp.3_RNA	NM_021215	NP_067038	Q9NQG5	RPR1B_HUMAN	Regulation of nuclear pre-mRNA domain containing	243										pancreas(1)	1						TATAACGGGCGCCTGGCAGCA	0.448			NA											19	99					1.33834e-09	1.62889e-09	0.007413	1	0
KIAA1755	85449	broad.mit.edu	37	20	36870200	36870201	+	Missense_Mutation	DNP	GG	GG	AT			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr20:36870200_36870201GG>AT	uc002xhy.1	-	3	604_605	c.332_333CC>AT	c.(331-333)CCC>CAT	p.P111H	KIAA1755_uc002xhz.1_Missense_Mutation_p.P111H	NM_001029864	NP_001025035	Q5JYT7	K1755_HUMAN	hypothetical protein LOC85449	111										ovary(4)|pancreas(1)	5		Myeloproliferative disorder(115;0.00874)				GCTCCTCCTGGGGCTCCACTTG	0.559			NA											20	117					0	0	0.004672	0	0
RALGAPB	57148	broad.mit.edu	37	20	37121587	37121587	+	Missense_Mutation	SNP	G	G	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr20:37121587G>A	uc002xiw.2	+	3	458	c.201G>A	c.(199-201)ATG>ATA	p.M67I	RALGAPB_uc010zvz.1_Missense_Mutation_p.M67I|RALGAPB_uc002xix.2_Missense_Mutation_p.M67I|RALGAPB_uc002xiy.1_Missense_Mutation_p.M67I|RALGAPB_uc002xiz.2_5'UTR	NM_020336	NP_065069	Q86X10	RLGPB_HUMAN	Ral GTPase activating protein, beta subunit	67					activation of Ral GTPase activity	intracellular	protein heterodimerization activity|Ral GTPase activator activity			pancreas(1)|skin(1)	2						AATGGACCATGGAAGTAATTT	0.348			NA											18	46					0	0	0.00499	0	0
SLC32A1	140679	broad.mit.edu	37	20	37357156	37357156	+	Missense_Mutation	SNP	G	G	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr20:37357156G>T	uc002xjc.2	+	2	1715	c.1452G>T	c.(1450-1452)AAG>AAT	p.K484N		NM_080552	NP_542119	Q9H598	VIAAT_HUMAN	solute carrier family 32, member 1	484	Lumenal, vesicle (Potential).				neurotransmitter secretion	clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|integral to membrane|plasma membrane|synaptic vesicle membrane	vesicular hydrogen:amino acid antiporter activity				0		Myeloproliferative disorder(115;0.00878)			Glycine(DB00145)	TCTGGCGCAAGCTGCTGTGGC	0.652			NA											26	42					7.07758e-08	8.34821e-08	0.004656	1	0
PPP1R16B	26051	broad.mit.edu	37	20	37546891	37546891	+	Missense_Mutation	SNP	G	G	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr20:37546891G>T	uc002xje.2	+	11	1475	c.1286G>T	c.(1285-1287)CGG>CTG	p.R429L	PPP1R16B_uc010ggc.2_Missense_Mutation_p.R387L	NM_015568	NP_056383	Q96T49	PP16B_HUMAN	protein phosphatase 1 regulatory inhibitor	429					regulation of filopodium assembly|signal transduction	nucleus|plasma membrane	protein phosphatase binding			upper_aerodigestive_tract(1)|kidney(1)|skin(1)	3		Myeloproliferative disorder(115;0.00878)				AATGGCCTCCGGGCTCCGGTC	0.597			NA											83	273					8.6486e-37	1.21214e-36	0.01441	1	0
EMILIN3	90187	broad.mit.edu	37	20	39990940	39990940	+	Silent	SNP	G	G	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr20:39990940G>A	uc002xjy.1	-	4	1493	c.1269C>T	c.(1267-1269)CTC>CTT	p.L423L		NM_052846	NP_443078	Q9NT22	EMIL3_HUMAN	elastin microfibril interfacer 3	423						proteinaceous extracellular matrix				ovary(1)	1		Myeloproliferative disorder(115;0.00425)				TGGCAGCAGAGAGCCTCGTAA	0.642			NA											22	121					0	0	0.014323	0	0
CHD6	84181	broad.mit.edu	37	20	40118549	40118549	+	Missense_Mutation	SNP	G	G	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr20:40118549G>A	uc002xka.1	-	12	1727	c.1549C>T	c.(1549-1551)CCT>TCT	p.P517S	CHD6_uc002xkd.2_Missense_Mutation_p.P495S	NM_032221	NP_115597	Q8TD26	CHD6_HUMAN	chromodomain helicase DNA binding protein 6	517	Helicase ATP-binding.				chromatin remodeling|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding			ovary(6)|skin(5)|lung(2)|central_nervous_system(1)	14		Myeloproliferative disorder(115;0.00425)				GTGGAGAGAGGGGCGATAATG	0.507			NA											32	72					0	0	0.009535	0	0
SLPI	6590	broad.mit.edu	37	20	43881764	43881764	+	Silent	SNP	C	C	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr20:43881764C>A	uc002xnm.1	-	3	295	c.273G>T	c.(271-273)GTG>GTT	p.V91V		NM_003064	NP_003055	P03973	SLPI_HUMAN	secretory leukocyte peptidase inhibitor	91	Elastase inhibitory domain.|WAP 2.					extracellular region	serine-type endopeptidase inhibitor activity			ovary(1)	1		Myeloproliferative disorder(115;0.0122)				GGCCATAAGTCACTGGGCACT	0.517	GBM(64;162 1089 31780 33427 34538)		NA											23	73					0.00395357	0.00410335	0.003954	1	0
PIGT	51604	broad.mit.edu	37	20	44054330	44054330	+	Missense_Mutation	SNP	C	C	G			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr20:44054330C>G	uc002xoh.1	+	12	1674	c.1601C>G	c.(1600-1602)ACT>AGT	p.T534S	PIGT_uc002xoj.1_Missense_Mutation_p.T467S|PIGT_uc002xok.1_Missense_Mutation_p.T499S|PIGT_uc010zwu.1_Missense_Mutation_p.T272S|PIGT_uc002xoi.1_RNA|PIGT_uc010zwv.1_Missense_Mutation_p.T272S|PIGT_uc010zww.1_Missense_Mutation_p.T478S|PIGT_uc010zwx.1_Missense_Mutation_p.T369S|PIGT_uc010zwy.1_Missense_Mutation_p.T432S|PIGT_uc010zwz.1_Missense_Mutation_p.T272S|PIGT_uc010zxa.1_Missense_Mutation_p.T372S|PIGT_uc002xol.1_Missense_Mutation_p.T323S|PIGT_uc010zxb.1_Missense_Mutation_p.T210S|PIGT_uc002xom.1_Missense_Mutation_p.T126S	NM_015937	NP_057021	Q969N2	PIGT_HUMAN	phosphatidylinositol glycan anchor biosynthesis,	534	Helical; (Potential).				attachment of GPI anchor to protein|C-terminal protein lipidation	GPI-anchor transamidase complex	protein binding			pancreas(1)	1		Myeloproliferative disorder(115;0.0122)				CTCACGTGCACTGTGGTGGCC	0.612			NA											8	62					0	0	0.00308	0	0
ELMO2	63916	broad.mit.edu	37	20	45002126	45002126	+	Missense_Mutation	SNP	C	C	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr20:45002126C>A	uc002xrt.1	-	16	1538	c.1328G>T	c.(1327-1329)CGA>CTA	p.R443L	ELMO2_uc010zxq.1_Missense_Mutation_p.R175L|ELMO2_uc002xrs.1_Missense_Mutation_p.R190L|ELMO2_uc002xru.1_Missense_Mutation_p.R443L|ELMO2_uc010zxr.1_Missense_Mutation_p.R455L|ELMO2_uc010zxs.1_Missense_Mutation_p.R260L|ELMO2_uc002xrv.1_Missense_Mutation_p.R162L|ELMO2_uc002xrw.2_Missense_Mutation_p.R260L	NM_133171	NP_573403	Q96JJ3	ELMO2_HUMAN	engulfment and cell motility 2	443	ELMO.				apoptosis|cell chemotaxis|phagocytosis	cytoskeleton|cytosol|membrane	lyase activity|receptor tyrosine kinase binding|SH3 domain binding			ovary(1)	1		Myeloproliferative disorder(115;0.0122)				TTCAAAGGCTCGGTCATGGGT	0.498			NA											18	56					5.3912e-06	6.04481e-06	0.006122	1	0
ZMYND8	23613	broad.mit.edu	37	20	45848953	45848953	+	Missense_Mutation	SNP	C	C	G			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr20:45848953C>G	uc002xta.1	-	21	3634	c.3380G>C	c.(3379-3381)AGA>ACA	p.R1127T	ZMYND8_uc010ghq.1_Intron|ZMYND8_uc010ghr.1_Missense_Mutation_p.R1029T|ZMYND8_uc002xst.1_Missense_Mutation_p.R1009T|ZMYND8_uc002xsu.1_Missense_Mutation_p.R1000T|ZMYND8_uc002xsv.1_Missense_Mutation_p.R1055T|ZMYND8_uc002xsw.1_Missense_Mutation_p.R833T|ZMYND8_uc002xsx.1_Missense_Mutation_p.R833T|ZMYND8_uc002xsy.1_Missense_Mutation_p.R1056T|ZMYND8_uc002xsz.1_Missense_Mutation_p.R1018T|ZMYND8_uc010zxy.1_Missense_Mutation_p.R1154T|ZMYND8_uc002xtb.1_Missense_Mutation_p.R1101T|ZMYND8_uc002xss.2_Missense_Mutation_p.R1127T|ZMYND8_uc010zxz.1_Missense_Mutation_p.R995T|ZMYND8_uc002xtc.1_Missense_Mutation_p.R1101T|ZMYND8_uc002xtd.1_Missense_Mutation_p.R1076T|ZMYND8_uc002xte.1_Missense_Mutation_p.R1081T|ZMYND8_uc010zya.1_Missense_Mutation_p.R1127T|ZMYND8_uc002xtf.1_Missense_Mutation_p.R1147T|ZMYND8_uc002xsr.1_Missense_Mutation_p.R226T	NM_012408	NP_036540	Q9ULU4	PKCB1_HUMAN	zinc finger, MYND-type containing 8 isoform b	1127							protein binding|zinc ion binding			central_nervous_system(2)|urinary_tract(1)|ovary(1)|skin(1)	5			Epithelial(1;0.0289)|all cancers(1;0.0962)|OV - Ovarian serous cystadenocarcinoma(1;0.154)			GGGCGTCTCTCTGGAGCCAGA	0.532			NA									OREG0026003	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	2	7					0	0	0.004672	0	0
ZNFX1	57169	broad.mit.edu	37	20	47886918	47886918	+	Silent	SNP	G	G	C			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr20:47886918G>C	uc002xui.2	-	3	1678	c.1431C>G	c.(1429-1431)CTC>CTG	p.L477L		NM_021035	NP_066363	Q9P2E3	ZNFX1_HUMAN	zinc finger, NFX1-type containing 1	477							metal ion binding			ovary(2)	2			BRCA - Breast invasive adenocarcinoma(12;0.00173)|COAD - Colon adenocarcinoma(4;0.14)|Colorectal(8;0.166)			TTCCTCGGCAGAGATCTTCCT	0.483			NA											16	93					0	0	0.004007	0	0
BCAS4	55653	broad.mit.edu	37	20	49458380	49458380	+	Silent	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr20:49458380C>T	uc002xvq.2	+	4	496	c.432C>T	c.(430-432)GCC>GCT	p.A144A	BCAS4_uc002xvr.2_Silent_p.A144A|BCAS4_uc002xvs.2_Intron	NM_017843	NP_060313	Q8TDM0	BCAS4_HUMAN	breast carcinoma amplified sequence 4 isoform a	144						cytoplasm					0						ACCATGGGGCCTTCCCTCAGG	0.652			NA											20	41					0	0	0.010504	0	0
TSHZ2	128553	broad.mit.edu	37	20	51872150	51872150	+	Missense_Mutation	SNP	G	G	C			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr20:51872150G>C	uc002xwo.2	+	2	3109	c.2153G>C	c.(2152-2154)TGC>TCC	p.C718S		NM_173485	NP_775756	Q9NRE2	TSH2_HUMAN	teashirt zinc finger homeobox 2	718					multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(5)|haematopoietic_and_lymphoid_tissue(1)	6			STAD - Stomach adenocarcinoma(23;0.1)			TCACCTTCCTGCTCCAGCCCA	0.582			NA											24	53					0	0	0.00333	0	0
CYP24A1	1591	broad.mit.edu	37	20	52774070	52774070	+	Missense_Mutation	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr20:52774070C>T	uc002xwv.2	-	10	1689	c.1291G>A	c.(1291-1293)GAT>AAT	p.D431N	CYP24A1_uc002xwu.1_Missense_Mutation_p.D289N|CYP24A1_uc002xww.2_Intron	NM_000782	NP_000773	Q07973	CP24A_HUMAN	cytochrome P450 family 24 subfamily A	431					hormone biosynthetic process|osteoblast differentiation|vitamin D catabolic process|vitamin D receptor signaling pathway|xenobiotic metabolic process	mitochondrial inner membrane	1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity|electron carrier activity|heme binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen			upper_aerodigestive_tract(1)|ovary(1)|lung(1)	3	Lung NSC(4;1.08e-05)|all_lung(4;2.7e-05)		STAD - Stomach adenocarcinoma(23;0.206)		Calcidiol(DB00146)|Calcitriol(DB00136)|Cholecalciferol(DB00169)|Ergocalciferol(DB00153)|Paricalcitol(DB00910)	TGACTTGAATCTTCAAAATTG	0.393			NA											15	89					0	0	0.003163	0	0
PCK1	5105	broad.mit.edu	37	20	56138681	56138681	+	Missense_Mutation	SNP	G	G	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr20:56138681G>T	uc002xyn.3	+	6	1022	c.859G>T	c.(859-861)GCC>TCC	p.A287S	PCK1_uc010zzm.1_Intron	NM_002591	NP_002582	P35558	PCKGC_HUMAN	cytosolic phosphoenolpyruvate carboxykinase 1	287	GTP.				gluconeogenesis|glucose homeostasis|glycerol biosynthetic process from pyruvate|response to insulin stimulus	cytosol|nucleus	carboxylic acid binding|GTP binding|magnesium ion binding|manganese ion binding|phosphoenolpyruvate carboxykinase (GTP) activity			skin(1)	1	Lung NSC(12;0.000764)|all_lung(29;0.00264)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(13;9.88e-12)|Epithelial(14;3.41e-08)|all cancers(14;2.13e-07)			ATTTCCCAGCGCCTGCGGGAA	0.542			NA											45	100					5.20006e-24	7.12983e-24	0.011902	1	0
PCK1	5105	broad.mit.edu	37	20	56140121	56140121	+	Silent	SNP	C	C	G			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr20:56140121C>G	uc002xyn.3	+	9	1507	c.1344C>G	c.(1342-1344)CTC>CTG	p.L448L	PCK1_uc010zzm.1_Silent_p.L131L	NM_002591	NP_002582	P35558	PCKGC_HUMAN	cytosolic phosphoenolpyruvate carboxykinase 1	448					gluconeogenesis|glucose homeostasis|glycerol biosynthetic process from pyruvate|response to insulin stimulus	cytosol|nucleus	carboxylic acid binding|GTP binding|magnesium ion binding|manganese ion binding|phosphoenolpyruvate carboxykinase (GTP) activity			skin(1)	1	Lung NSC(12;0.000764)|all_lung(29;0.00264)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(13;9.88e-12)|Epithelial(14;3.41e-08)|all cancers(14;2.13e-07)			ATGAAGCTCTCAGCTGGCAAC	0.463			NA											18	136					0	0	0.006122	0	0
TH1L	51497	broad.mit.edu	37	20	57569177	57569177	+	Missense_Mutation	SNP	A	A	G			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr20:57569177A>G	uc002yag.2	+	14	1648	c.1621A>G	c.(1621-1623)ATT>GTT	p.I541V	TH1L_uc002yaf.1_RNA|TH1L_uc002yah.2_Missense_Mutation_p.H511R	NM_198976	NP_945327	Q8IXH7	NELFD_HUMAN	TH1-like protein	541					negative regulation of transcription, DNA-dependent|positive regulation of viral transcription|transcription elongation from RNA polymerase II promoter|viral reproduction	nucleoplasm	protein binding			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3	all_lung(29;0.00711)		Colorectal(105;0.109)			GCTGGACGTCATTGCTCCTCC	0.557			NA											16	76					0	0	0.004007	0	0
ZNF831	128611	broad.mit.edu	37	20	57768421	57768421	+	Missense_Mutation	SNP	C	C	G			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr20:57768421C>G	uc002yan.2	+	1	2347	c.2347C>G	c.(2347-2349)CCC>GCC	p.P783A		NM_178457	NP_848552	Q5JPB2	ZN831_HUMAN	zinc finger protein 831	783						intracellular	nucleic acid binding|zinc ion binding			skin(13)|ovary(1)	14	all_lung(29;0.0085)					TTGGCCGGACCCCAAGCTGGA	0.657			NA											16	33					0	0	0.006122	0	0
ZNF831	128611	broad.mit.edu	37	20	57769224	57769224	+	Missense_Mutation	SNP	G	G	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr20:57769224G>T	uc002yan.2	+	1	3150	c.3150G>T	c.(3148-3150)GAG>GAT	p.E1050D		NM_178457	NP_848552	Q5JPB2	ZN831_HUMAN	zinc finger protein 831	1050						intracellular	nucleic acid binding|zinc ion binding			skin(13)|ovary(1)	14	all_lung(29;0.0085)					CTCCCAGGGAGGCTACCTCCT	0.632			NA											18	31					1.99824e-07	2.3286e-07	0.00499	1	0
LAMA5	3911	broad.mit.edu	37	20	60890259	60890259	+	Missense_Mutation	SNP	C	C	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr20:60890259C>A	uc002ycq.2	-	59	7939	c.7872G>T	c.(7870-7872)GAG>GAT	p.E2624D		NM_005560	NP_005551	O15230	LAMA5_HUMAN	laminin alpha 5 precursor	2624	Potential.|Domain II and I.				angiogenesis|cell proliferation|cell recognition|cytoskeleton organization|endothelial cell differentiation|focal adhesion assembly|integrin-mediated signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-11 complex	integrin binding			ovary(1)|pancreas(1)|skin(1)	3	Breast(26;1.57e-08)		BRCA - Breast invasive adenocarcinoma(19;4.36e-06)		Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	TCTTGCTTGTCTCGTCTGTGG	0.622			NA											12	33					4.36969e-10	5.34523e-10	0.001855	1	0
NTSR1	4923	broad.mit.edu	37	20	61386117	61386117	+	Silent	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr20:61386117C>T	uc002ydf.2	+	2	1166	c.795C>T	c.(793-795)GTC>GTT	p.V265V		NM_002531	NP_002522	P30989	NTR1_HUMAN	neurotensin receptor 1	265	Cytoplasmic (Potential).					endoplasmic reticulum|Golgi apparatus|integral to plasma membrane	neurotensin receptor activity, G-protein coupled			skin(2)|lung(1)|central_nervous_system(1)	4	Breast(26;3.65e-08)		BRCA - Breast invasive adenocarcinoma(19;3.63e-06)			AGCTGACCGTCATGGTACGCC	0.617	GBM(37;400 780 6403 19663 35669)		NA											10	103					0	0	0.006214	0	0
COL9A3	1299	broad.mit.edu	37	20	61461738	61461738	+	Silent	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr20:61461738C>T	uc002ydm.2	+	23	1191	c.1188C>T	c.(1186-1188)CCC>CCT	p.P396P		NM_001853	NP_001844	Q14050	CO9A3_HUMAN	alpha 3 type IX collagen precursor	396	Triple-helical region 3 (COL3).				axon guidance	collagen type IX					0	Breast(26;5.68e-08)					AAGGCCCTCCCGGAGCCCCTG	0.692			NA											3	5					0	0	0.009096	0	0
CHRNA4	1137	broad.mit.edu	37	20	61981575	61981575	+	Missense_Mutation	SNP	G	G	C			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr20:61981575G>C	uc002yes.2	-	5	1366	c.1188C>G	c.(1186-1188)AGC>AGG	p.S396R	CHRNA4_uc002yet.1_Missense_Mutation_p.S220R|CHRNA4_uc011aaw.1_RNA|CHRNA4_uc010gke.1_Missense_Mutation_p.S325R|CHRNA4_uc002yev.1_Missense_Mutation_p.S220R|CHRNA4_uc010gkf.1_Missense_Mutation_p.S220R	NM_000744	NP_000735	P43681	ACHA4_HUMAN	cholinergic receptor, nicotinic, alpha 4 subunit	396	Cytoplasmic (Potential).				B cell activation|behavioral response to nicotine|calcium ion transport|cognition|DNA repair|membrane depolarization|regulation of action potential|regulation of dopamine secretion|regulation of inhibitory postsynaptic membrane potential|response to hypoxia|response to oxidative stress|sensory perception of pain|synaptic transmission, cholinergic	cell junction|dendrite|external side of plasma membrane|membrane fraction|neuronal cell body|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity			central_nervous_system(1)|skin(1)	2	all_cancers(38;1.71e-10)				Nicotine(DB00184)|Varenicline(DB01273)	TCTGGGTGCCGCTCGTGGCAG	0.672			NA											5	20					0	0	0.00308	0	0
TCEA2	6919	broad.mit.edu	37	20	62701953	62701953	+	Missense_Mutation	SNP	G	G	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr20:62701953G>T	uc011abs.1	+	8	1440	c.784G>T	c.(784-786)GGC>TGC	p.G262C	TCEA2_uc011abr.1_Missense_Mutation_p.G235C|TCEA2_uc010gks.2_Missense_Mutation_p.G263C	NM_003195	NP_003186	Q15560	TCEA2_HUMAN	transcription elongation factor A protein 2	262	TFIIS-type.				regulation of transcription elongation, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription elongation, DNA-dependent	transcription elongation factor complex	DNA binding|protein binding|translation elongation factor activity|zinc ion binding				0	all_cancers(38;3.45e-11)|all_epithelial(29;9.12e-13)|Lung NSC(23;2e-09)|all_lung(23;6.77e-09)					GTTCACCTGCGGCAAGTGCAG	0.632			NA											11	18					9.70103e-10	1.18468e-09	0.008291	1	0
LIPI	149998	broad.mit.edu	37	21	15558333	15558333	+	Missense_Mutation	SNP	T	T	C			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr21:15558333T>C	uc002yjm.2	-	3	563	c.553A>G	c.(553-555)ATC>GTC	p.I185V	LIPI_uc010gkw.1_Missense_Mutation_p.I118V	NM_198996	NP_945347	Q6XZB0	LIPI_HUMAN	lipase, member I	164					lipid catabolic process	extracellular region|extracellular space|membrane|plasma membrane	heparin binding|phospholipase activity			ovary(2)	2				Epithelial(23;0.000155)|COAD - Colon adenocarcinoma(22;0.0015)|Colorectal(24;0.00693)|Lung(58;0.166)		AATCCACTGATATGAGCCCCT	0.313			NA											92	56					0	0	0.01441	0	0
JAM2	58494	broad.mit.edu	37	21	27086965	27086965	+	Missense_Mutation	SNP	C	C	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr21:27086965C>A	uc002ylp.1	+	10	1423	c.878C>A	c.(877-879)ACA>AAA	p.T293K	JAM2_uc002ylq.1_RNA|JAM2_uc011acf.1_Missense_Mutation_p.T257K|JAM2_uc010glh.1_RNA|JAM2_uc002ylr.1_Missense_Mutation_p.T289K|JAM2_uc010gli.1_Missense_Mutation_p.Q275K	NM_021219	NP_067042	P57087	JAM2_HUMAN	junctional adhesion molecule 2 precursor	293	Cytoplasmic (Potential).			DFKHTKSFII -> VQWLTPVIPALWKAAAGGSRGQEF (in Ref. 4; AAQ88727).	blood coagulation|cell-cell adhesion|leukocyte migration	integral to plasma membrane|tight junction					0						TTCAAGCACACAAAATCCTTT	0.274			NA											10	19					0.000442599	0.000469777	0.006214	1	0
ADAMTS1	9510	broad.mit.edu	37	21	28216601	28216601	+	Missense_Mutation	SNP	C	C	G			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr21:28216601C>G	uc002ymf.2	-	1	1128	c.673G>C	c.(673-675)GAA>CAA	p.E225Q		NM_006988	NP_008919	Q9UHI8	ATS1_HUMAN	ADAM metallopeptidase with thrombospondin type 1	225					integrin-mediated signaling pathway|negative regulation of cell proliferation|proteolysis		heparin binding|zinc ion binding			lung(3)|large_intestine(2)|central_nervous_system(1)	6		Breast(209;0.000962)		Lung(58;0.215)		TGAGCCCCTTCGTCCTCGCCC	0.652			NA									OREG0026151	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	3	13					0	0	0.004672	0	0
RNF160	26046	broad.mit.edu	37	21	30304987	30304987	+	Splice_Site	SNP	C	C	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr21:30304987C>A	uc002ymr.2	-	28	5027	c.5014_splice	c.e28-1	p.V1672_splice		NM_015565	NP_056380	O94822	LTN1_HUMAN	zinc finger protein 294								ligase activity|zinc ion binding				0						GAGCTTTAACCTGCAATACAA	0.343			NA											10	61					2.17888e-05	2.40588e-05	0.006214	1	0
CLDN17	26285	broad.mit.edu	37	21	31538717	31538717	+	Silent	SNP	G	G	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr21:31538717G>A	uc011acv.1	-	1	219	c.219C>T	c.(217-219)CTC>CTT	p.L73L		NM_012131	NP_036263	P56750	CLD17_HUMAN	claudin 17	73	Extracellular (Potential).				calcium-independent cell-cell adhesion|tight junction assembly	Golgi apparatus|integral to membrane|tight junction	identical protein binding|structural molecule activity			ovary(2)	2						GGGCAGGCGGGAGAGCCAACA	0.552			NA											14	59					0	0	0.00245	0	0
KRTAP13-2	337959	broad.mit.edu	37	21	31744334	31744334	+	Missense_Mutation	SNP	G	G	C			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr21:31744334G>C	uc002ynz.3	-	1	224	c.198C>G	c.(196-198)TGC>TGG	p.C66W		NM_181621	NP_853652	Q52LG2	KR132_HUMAN	keratin associated protein 13-2	66	3.|5 X 10 AA approximate repeats.					intermediate filament					0						AGGACGTCTGGCAGCTGGTGG	0.602			NA											13	42					0	0	0.001855	0	0
KRTAP15-1	254950	broad.mit.edu	37	21	31813004	31813004	+	Missense_Mutation	SNP	G	G	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr21:31813004G>A	uc002yod.2	+	1	359	c.359G>A	c.(358-360)AGC>AAC	p.S120N		NM_181623	NP_853654	Q3LI76	KR151_HUMAN	keratin associated protein 15-1	120						intermediate filament					0						TGTGGGTCCAGCTTCTACCAC	0.473			NA											18	62					0	0	0.006122	0	0
GCFC1	94104	broad.mit.edu	37	21	34117954	34117954	+	Nonsense_Mutation	SNP	C	C	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr21:34117954C>A	uc002yqn.2	-	12	2189	c.1999G>T	c.(1999-2001)GAA>TAA	p.E667*	GCFC1_uc002yql.2_Nonsense_Mutation_p.E176*|GCFC1_uc002yqm.2_Nonsense_Mutation_p.E161*|GCFC1_uc002yqo.2_RNA|GCFC1_uc002yqp.2_Nonsense_Mutation_p.E667*	NM_016631	NP_057715	Q9Y5B6	GCFC1_HUMAN	GC-rich sequence DNA-binding factor candidate	667						cytosol|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(2)	2						TCATCTTTTTCTTGCTCTCGT	0.378			NA											8	35					0.00307968	0.00319864	0.00308	1	0
RUNX1	861	broad.mit.edu	37	21	36231792	36231792	+	Missense_Mutation	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr21:36231792C>T	uc002yuh.2	-	3	2089	c.511G>A	c.(511-513)GAT>AAT	p.D171N	RUNX1_uc002yui.2_Missense_Mutation_p.D171N|RUNX1_uc010gmu.2_Missense_Mutation_p.D198N|RUNX1_uc010gmv.2_Missense_Mutation_p.D198N|RUNX1_uc002yuj.3_Missense_Mutation_p.D66N|RUNX1_uc002yuk.3_Missense_Mutation_p.D198N|RUNX1_uc002yum.1_Missense_Mutation_p.D66N|RUNX1_uc010gmw.1_Missense_Mutation_p.D198N|RUNX1_uc002yuo.1_Missense_Mutation_p.D171N|RUNX1_uc002yur.1_Missense_Mutation_p.D66N|uc002yus.1_RNA	NM_001001890	NP_001001890	Q01196	RUNX1_HUMAN	runt-related transcription factor 1 isoform	171	Interaction with DNA.|Runt.			D->A: Strongly reduces DNA-binding.|Missing: No DNA-binding.	myeloid cell differentiation|negative regulation of granulocyte differentiation|positive regulation of angiogenesis|positive regulation of granulocyte differentiation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent	nucleus|nucleus	ATP binding|calcium ion binding|DNA binding|DNA binding|protein binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|sequence-specific DNA binding transcription factor activity|transcription factor binding	p.D198N(9)|p.G170_K171insRRG(1)|p.K171N(1)		haematopoietic_and_lymphoid_tissue(383)|lung(2)|ovary(1)|central_nervous_system(1)	387						CGGGGCCCATCCACTGTGATT	0.557			NA	T	RPL22|MDS1|EVI1|CBFA2T3|CBFA2T1|ETV6|LAF4	AML|preB- ALL|T-ALL				Platelet_disorder_associated_with_Myeloid_Malignancies				16	63					0	0	0.007413	0	0
KCNJ6	3763	broad.mit.edu	37	21	39086866	39086866	+	Missense_Mutation	SNP	C	C	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr21:39086866C>A	uc011aej.1	-	3	647	c.594G>T	c.(592-594)AAG>AAT	p.K198N	KCNJ6_uc002ywo.2_Missense_Mutation_p.K198N	NM_002240	NP_002231	P48051	IRK6_HUMAN	potassium inwardly-rectifying channel J6	198	Cytoplasmic (By similarity).				synaptic transmission	Golgi apparatus|voltage-gated potassium channel complex	G-protein activated inward rectifier potassium channel activity|protein binding			skin(1)	1					Halothane(DB01159)	TCTCTGCCCTCTTCTTGGGTT	0.483	Pancreas(48;379 1118 2936 19024 28214)		NA											18	50					5.03518e-11	6.27023e-11	0.007413	1	0
UMODL1	89766	broad.mit.edu	37	21	43508578	43508578	+	Missense_Mutation	SNP	G	G	C			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr21:43508578G>C	uc002zaf.1	+	5	778	c.778G>C	c.(778-780)GTC>CTC	p.V260L	UMODL1_uc002zad.1_Missense_Mutation_p.V188L|UMODL1_uc002zae.1_Missense_Mutation_p.V188L|UMODL1_uc002zag.1_Missense_Mutation_p.V260L|UMODL1_uc010gow.1_Missense_Mutation_p.V52L|UMODL1_uc002zai.1_5'UTR|UMODL1_uc010gox.1_RNA|UMODL1_uc010goy.1_Intron|UMODL1_uc002zaj.1_RNA|UMODL1_uc010goz.1_Missense_Mutation_p.V52L	NM_001004416	NP_001004416	Q5DID0	UROL1_HUMAN	uromodulin-like 1 isoform 1 precursor	260	Extracellular (Potential).					cytoplasm|extracellular region|integral to membrane|plasma membrane	calcium ion binding|peptidase inhibitor activity			ovary(2)|skin(1)	3						AGTGATCAGCGTCCAGGTGCA	0.607	Pancreas(122;680 807 13940 14411 22888 25505 31742 36028 36332 38435)		NA											3	7					0	0	0.004672	0	0
ABCG1	9619	broad.mit.edu	37	21	43621828	43621828	+	Missense_Mutation	SNP	C	C	G			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr21:43621828C>G	uc002zan.2	+	2	303	c.43C>G	c.(43-45)CCT>GCT	p.P15A	ABCG1_uc002zam.2_5'UTR	NM_207627	NP_997510	P45844	ABCG1_HUMAN	ATP-binding cassette sub-family G member 1	Error:Variant_position_missing_in_P45844_after_alignment					amyloid precursor protein catabolic process|cholesterol efflux|cholesterol homeostasis|cholesterol metabolic process|detection of hormone stimulus|high-density lipoprotein particle remodeling|intracellular cholesterol transport|lipoprotein metabolic process|low-density lipoprotein particle remodeling|negative regulation of cholesterol storage|negative regulation of macrophage derived foam cell differentiation|phospholipid efflux|phospholipid homeostasis|positive regulation of cholesterol biosynthetic process|regulation of cholesterol esterification|regulation of transcription, DNA-dependent|response to lipid|reverse cholesterol transport	endoplasmic reticulum membrane|external side of plasma membrane|Golgi membrane|recycling endosome	ADP binding|ATP binding|cholesterol transporter activity|glycoprotein transporter activity|phospholipid transporter activity|protein heterodimerization activity|protein homodimerization activity|sterol-transporting ATPase activity|toxin transporter activity			ovary(2)|central_nervous_system(1)	3					Adenosine triphosphate(DB00171)	aaagccctgccctcaGGTGTG	0.289			NA											9	12					0	0	0.004482	0	0
KRTAP10-8	386681	broad.mit.edu	37	21	46032130	46032130	+	Missense_Mutation	SNP	G	G	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr21:46032130G>T	uc002zfo.1	+	1	135	c.113G>T	c.(112-114)GGC>GTC	p.G38V	C21orf29_uc002zfe.1_Intron|C21orf29_uc010gpv.1_Intron	NM_198695	NP_941968	P60410	KR108_HUMAN	keratin associated protein 10-8	38	19 X 5 AA repeats of C-C-X(3).					keratin filament				large_intestine(1)|breast(1)	2						ACCTGCACTGGCTCCTCCTGG	0.637			NA											26	56					7.92952e-12	1.00032e-11	0.003954	1	0
KRTAP10-11	386678	broad.mit.edu	37	21	46066935	46066935	+	Missense_Mutation	SNP	C	C	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr21:46066935C>A	uc002zfr.3	+	1	605	c.560C>A	c.(559-561)GCC>GAC	p.A187D	C21orf29_uc002zfe.1_Intron|C21orf29_uc010gpv.1_Intron	NM_198692	NP_941965	P60412	KR10B_HUMAN	keratin associated protein 10-11	187	25 X 5 AA repeats of C-C-X(3).					keratin filament				ovary(1)	1						TACCAGCAGGCCTGCTGCGTG	0.602			NA											63	136					4.45325e-31	6.21743e-31	0.01441	1	0
CLTCL1	8218	broad.mit.edu	37	22	19175510	19175510	+	Missense_Mutation	SNP	C	C	G			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr22:19175510C>G	uc002zpb.2	-	29	4492	c.4417G>C	c.(4417-4419)GAG>CAG	p.E1473Q	CLTCL1_uc011agv.1_Missense_Mutation_p.E1473Q|CLTCL1_uc011agw.1_Missense_Mutation_p.E1452Q|CLTCL1_uc011agt.1_Missense_Mutation_p.E264Q|CLTCL1_uc011agu.1_Intron	NM_007098	NP_009029	P53675	CLH2_HUMAN	clathrin, heavy polypeptide-like 1 isoform 1	1473	Involved in binding clathrin light chain (By similarity).|Proximal segment.|Heavy chain arm.				anatomical structure morphogenesis|intracellular protein transport|mitosis|positive regulation of glucose import|receptor-mediated endocytosis	clathrin coat of coated pit|clathrin coat of trans-Golgi network vesicle|spindle|trans-Golgi network	protein binding|signal transducer activity|structural molecule activity			ovary(4)|central_nervous_system(1)	5	Colorectal(54;0.0993)					TCCTCCTCCTCTGTCAGCAGG	0.592			NA	T	?	ALCL								24	148					0	0	0.00333	0	0
Unknown	0	broad.mit.edu	37	22	20721917	20721917	+	Missense_Mutation	SNP	C	C	G			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr22:20721917C>G	uc011ahp.1	-	4	397	c.98G>C	c.(97-99)TGC>TCC	p.C33S	uc011ahq.1_Missense_Mutation_p.C141S					SubName: Full=cDNA FLJ59031, highly similar to Ubl carboxyl-terminal hydrolase 18 (EC 3.1.2.-);												NA						CTGGAAGAAGCAGTGCAGGGC	0.433			NA											2	8					0	0	0.004672	0	0
PPM1F	9647	broad.mit.edu	37	22	22280013	22280013	+	Missense_Mutation	SNP	G	G	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr22:22280013G>A	uc002zvp.1	-	7	1028	c.914C>T	c.(913-915)GCA>GTA	p.A305V	PPM1F_uc011aik.1_Missense_Mutation_p.A201V|PPM1F_uc002zvq.2_Missense_Mutation_p.A305V	NM_014634	NP_055449	P49593	PPM1F_HUMAN	protein phosphatase 1F	305					apoptosis|protein dephosphorylation	protein serine/threonine phosphatase complex	metal ion binding|protein serine/threonine phosphatase activity			ovary(2)|large_intestine(1)|breast(1)|kidney(1)	5	Colorectal(54;0.105)			READ - Rectum adenocarcinoma(21;0.155)		GCCACCCAATGCTTCAATGCG	0.627			NA											5	49					0	0	0.000602	0	0
VPREB1	7441	broad.mit.edu	37	22	22599589	22599589	+	Missense_Mutation	SNP	T	T	G			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr22:22599589T>G	uc002zvx.1	+	2	304	c.278T>G	c.(277-279)GTG>GGG	p.V93G	LOC96610_uc011aim.1_Intron	NM_007128	NP_009059	P12018	VPREB_HUMAN	immunoglobulin iota chain precursor	93	Ig-like V-type.|Framework-3.				immune response	extracellular region	antigen binding|protein binding				0	all_hematologic(9;0.0312)|Acute lymphoblastic leukemia(84;0.155)	all_cancers(3;3.14e-14)|Acute lymphoblastic leukemia(3;2.97e-57)|all_hematologic(3;5.9e-52)		READ - Rectum adenocarcinoma(21;0.145)		TCCAAAGATGTGGCCAGGAAC	0.552			NA											36	68					0	0	0.003271	0	0
VPREB1	7441	broad.mit.edu	37	22	22599591	22599591	+	Missense_Mutation	SNP	G	G	C			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr22:22599591G>C	uc002zvx.1	+	2	306	c.280G>C	c.(280-282)GCC>CCC	p.A94P	LOC96610_uc011aim.1_Intron	NM_007128	NP_009059	P12018	VPREB_HUMAN	immunoglobulin iota chain precursor	94	Ig-like V-type.|Framework-3.				immune response	extracellular region	antigen binding|protein binding				0	all_hematologic(9;0.0312)|Acute lymphoblastic leukemia(84;0.155)	all_cancers(3;3.14e-14)|Acute lymphoblastic leukemia(3;2.97e-57)|all_hematologic(3;5.9e-52)		READ - Rectum adenocarcinoma(21;0.145)		CAAAGATGTGGCCAGGAACAG	0.547			NA											35	64					0	0	0.013726	0	0
ZNF280B	140883	broad.mit.edu	37	22	22842568	22842568	+	Nonsense_Mutation	SNP	G	G	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr22:22842568G>A	uc002zwc.1	-	4	1932	c.1156C>T	c.(1156-1158)CAG>TAG	p.Q386*	LOC96610_uc011aim.1_Intron	NM_080764	NP_542942	Q86YH2	Z280B_HUMAN	zinc finger protein 280B	386	C2H2-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2	all_hematologic(9;0.0135)|Acute lymphoblastic leukemia(84;0.17)	all_hematologic(6;1.74e-30)|Acute lymphoblastic leukemia(6;7.75e-22)		READ - Rectum adenocarcinoma(21;0.145)		AAGAGGACCTGATCTGTTTCA	0.468			NA											16	88					0	0	0.004007	0	0
ZNF280B	140883	broad.mit.edu	37	22	22843099	22843099	+	Missense_Mutation	SNP	G	G	C			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr22:22843099G>C	uc002zwc.1	-	4	1401	c.625C>G	c.(625-627)CAT>GAT	p.H209D	LOC96610_uc011aim.1_Intron	NM_080764	NP_542942	Q86YH2	Z280B_HUMAN	zinc finger protein 280B	209					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2	all_hematologic(9;0.0135)|Acute lymphoblastic leukemia(84;0.17)	all_hematologic(6;1.74e-30)|Acute lymphoblastic leukemia(6;7.75e-22)		READ - Rectum adenocarcinoma(21;0.145)		TTCATTGTATGAAAGGTATCT	0.393			NA											20	83					0	0	0.010504	0	0
PRAME	23532	broad.mit.edu	37	22	22892257	22892257	+	Missense_Mutation	SNP	C	C	G			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr22:22892257C>G	uc002zwf.2	-	4	1000	c.844G>C	c.(844-846)GAG>CAG	p.E282Q	LOC96610_uc011aim.1_Intron|PRAME_uc011air.1_Missense_Mutation_p.E266Q|PRAME_uc010gtr.2_Missense_Mutation_p.E282Q|PRAME_uc002zwg.2_Missense_Mutation_p.E282Q|PRAME_uc002zwh.2_Missense_Mutation_p.E282Q|PRAME_uc002zwi.2_Missense_Mutation_p.E282Q|PRAME_uc002zwj.2_Missense_Mutation_p.E282Q|PRAME_uc002zwk.2_Missense_Mutation_p.E282Q	NM_206956	NP_996839	P78395	PRAME_HUMAN	preferentially expressed antigen in melanoma	282					apoptosis|cell differentiation|negative regulation of apoptosis|negative regulation of cell differentiation|negative regulation of retinoic acid receptor signaling pathway|negative regulation of transcription, DNA-dependent|positive regulation of cell proliferation|regulation of growth|transcription, DNA-dependent	nucleus|plasma membrane	retinoic acid receptor binding			central_nervous_system(2)	2	all_hematologic(9;0.0135)|Acute lymphoblastic leukemia(84;0.17)	all_hematologic(6;1.74e-30)|Acute lymphoblastic leukemia(6;7.75e-22)|all_lung(157;4.03e-05)		READ - Rectum adenocarcinoma(21;0.0649)		ATATACTGCTCTTCCTTCTCC	0.502	Melanoma(73;1707 1838 15168 27201)		NA											9	50					0	0	0.006214	0	0
SUSD2	56241	broad.mit.edu	37	22	24580910	24580910	+	Splice_Site	SNP	T	T	G			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr22:24580910T>G	uc002zzn.1	+	5	826	c.782_splice	c.e5+2	p.K261_splice		NM_019601	NP_062547	Q9UGT4	SUSD2_HUMAN	sushi domain containing 2 precursor						immune response	integral to membrane	polysaccharide binding|protein binding|scavenger receptor activity			skin(1)	1						AGGGCAGAAGTAAGAAGGCAT	0.607			NA											11	29					0	0	0.013537	0	0
MYO18B	84700	broad.mit.edu	37	22	26242238	26242238	+	Missense_Mutation	SNP	C	C	G			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr22:26242238C>G	uc003abz.1	+	19	3790	c.3540C>G	c.(3538-3540)ATC>ATG	p.I1180M	MYO18B_uc003aca.1_Missense_Mutation_p.I1061M|MYO18B_uc010guy.1_Missense_Mutation_p.I1062M|MYO18B_uc010guz.1_Missense_Mutation_p.I1061M|MYO18B_uc011aka.1_Missense_Mutation_p.I334M|MYO18B_uc011akb.1_Missense_Mutation_p.I693M	NM_032608	NP_115997	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	1180	Myosin head-like.					nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity			ovary(5)|central_nervous_system(3)|large_intestine(2)|breast(2)	12						GCTCCCAGATCAAGCTGCAGA	0.542			NA											23	30					0	0	0.014323	0	0
GAL3ST1	9514	broad.mit.edu	37	22	30951246	30951246	+	Silent	SNP	G	G	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr22:30951246G>A	uc003aig.1	-	4	1106	c.966C>T	c.(964-966)TTC>TTT	p.F322F	GAL3ST1_uc003aih.1_Silent_p.F322F|GAL3ST1_uc003aii.1_Silent_p.F322F|GAL3ST1_uc010gvz.1_Silent_p.F322F	NM_004861	NP_004852	Q99999	G3ST1_HUMAN	galactose-3-O-sulfotransferase 1	322	Lumenal (Potential).				protein N-linked glycosylation	Golgi membrane|integral to plasma membrane|membrane fraction	galactosylceramide sulfotransferase activity				0						GCTCCCGCCCGAAGGCCTCCA	0.711			NA											4	22					0	0	0.000602	0	0
PATZ1	23598	broad.mit.edu	37	22	31722972	31722972	+	Missense_Mutation	SNP	C	C	G			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr22:31722972C>G	uc003akq.2	-	5	2630	c.1969G>C	c.(1969-1971)GAG>CAG	p.E657Q	PATZ1_uc003akp.2_3'UTR|PATZ1_uc003akr.2_Missense_Mutation_p.E611Q	NM_014323	NP_055138	Q9HBE1	PATZ1_HUMAN	POZ (BTB) and AT hook containing zinc finger 1	657					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding		EWSR1/PATZ1(2)	soft_tissue(2)	2						CCAAAGGACTCGAGGAGAGAC	0.582			NA											9	92					0	0	0.006214	0	0
EIF4ENIF1	56478	broad.mit.edu	37	22	31850252	31850252	+	Missense_Mutation	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr22:31850252C>T	uc003akz.1	-	10	1554	c.1390G>A	c.(1390-1392)GAG>AAG	p.E464K	EIF4ENIF1_uc003akx.1_Missense_Mutation_p.E143K|EIF4ENIF1_uc003aky.1_Missense_Mutation_p.E143K|EIF4ENIF1_uc003ala.1_Missense_Mutation_p.E464K|EIF4ENIF1_uc003alb.1_Missense_Mutation_p.E301K	NM_019843	NP_062817	Q9NRA8	4ET_HUMAN	eukaryotic translation initiation factor 4E	464						nucleus	protein binding|protein transporter activity			ovary(1)	1						CTCAAGGTCTCTTCTAGGTGT	0.483			NA											13	70					0	0	0.013537	0	0
DEPDC5	9681	broad.mit.edu	37	22	32217561	32217561	+	Silent	SNP	G	G	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr22:32217561G>A	uc003als.2	+	23	2086	c.1944G>A	c.(1942-1944)CAG>CAA	p.Q648Q	DEPDC5_uc011als.1_Intron|DEPDC5_uc011alu.1_Silent_p.Q648Q|DEPDC5_uc011alv.1_Intron|DEPDC5_uc003alt.2_Silent_p.Q648Q|DEPDC5_uc003alu.2_Silent_p.Q88Q|DEPDC5_uc003alv.2_Intron|DEPDC5_uc011alw.1_5'Flank|DEPDC5_uc011alt.1_Intron	NM_014662	NP_055477	O75140	DEPD5_HUMAN	DEP domain containing 5 isoform 1	648					intracellular signal transduction					ovary(4)|central_nervous_system(3)|pancreas(1)	8						GCAGCGGGCAGAGGGATCCAA	0.552			NA											64	121					0	0	0.01441	0	0
LARGE	9215	broad.mit.edu	37	22	33673054	33673054	+	Missense_Mutation	SNP	C	C	G			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr22:33673054C>G	uc003and.3	-	15	2644	c.2065G>C	c.(2065-2067)GAT>CAT	p.D689H	LARGE_uc011amd.1_Missense_Mutation_p.D488H|LARGE_uc003ane.3_Missense_Mutation_p.D689H|LARGE_uc010gwp.2_Missense_Mutation_p.D637H|LARGE_uc011ame.1_Missense_Mutation_p.D621H|LARGE_uc011amf.1_Missense_Mutation_p.D640H	NM_004737	NP_004728	O95461	LARGE_HUMAN	like-glycosyltransferase	689	Lumenal (Potential).				glycosphingolipid biosynthetic process|muscle cell homeostasis|N-acetylglucosamine metabolic process|protein glycosylation	integral to Golgi membrane	acetylglucosaminyltransferase activity			ovary(1)|central_nervous_system(1)|skin(1)	3		Lung NSC(1;0.219)				ACCTGCACATCCAGCTCCATG	0.532	Colon(70;397 1175 4573 19089 45288)		NA											11	48					0	0	0.008291	0	0
MCM5	4174	broad.mit.edu	37	22	35804479	35804479	+	Missense_Mutation	SNP	G	G	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr22:35804479G>T	uc003anu.3	+	6	769	c.675G>T	c.(673-675)CAG>CAT	p.Q225H	MCM5_uc010gwr.2_Missense_Mutation_p.Q34H|MCM5_uc003anv.3_Missense_Mutation_p.Q182H|MCM5_uc010gws.1_RNA|MCM5_uc003anw.1_5'Flank	NM_006739	NP_006730	P33992	MCM5_HUMAN	minichromosome maintenance complex component 5	225					cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	MCM complex	ATP binding|DNA binding|helicase activity|protein binding			ovary(1)	1						TGGACTTCCAGACCCTGAAGC	0.582			NA											20	50					0.000958276	0.00101047	0.007413	1	0
CACNG2	10369	broad.mit.edu	37	22	37098576	37098576	+	Missense_Mutation	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr22:37098576C>T	uc003aps.1	-	1	328	c.46G>A	c.(46-48)GGT>AGT	p.G16S	uc003apt.1_5'Flank	NM_006078	NP_006069	Q9Y698	CCG2_HUMAN	voltage-dependent calcium channel gamma-2	16	Helical; (Potential).				membrane depolarization|regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|endocytic vesicle membrane|voltage-gated calcium channel complex	protein binding|voltage-gated calcium channel activity				0						GCGAAAGCACCAACGGTGGTT	0.473			NA											43	87					0	0	0.00874	0	0
SSTR3	6753	broad.mit.edu	37	22	37603250	37603250	+	Missense_Mutation	SNP	G	G	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr22:37603250G>T	uc003ara.2	-	2	655	c.593C>A	c.(592-594)CCG>CAG	p.P198Q	SSTR3_uc003arb.2_Missense_Mutation_p.P198Q	NM_001051	NP_001042	P32745	SSR3_HUMAN	somatostatin receptor 3	198	Extracellular (Potential).				G-protein signaling, coupled to cyclic nucleotide second messenger|induction of apoptosis by hormones|negative regulation of cell proliferation	integral to plasma membrane|nonmotile primary cilium	somatostatin receptor activity			lung(1)	1						GGCCGCCGCCGGCTCGGGCCA	0.692			NA											33	24					2.09667e-21	2.83989e-21	0.003755	1	0
SH3BP1	23616	broad.mit.edu	37	22	38051611	38051611	+	Missense_Mutation	SNP	G	G	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr22:38051611G>A	uc003ati.2	+	18	2137	c.2026G>A	c.(2026-2028)GAG>AAG	p.E676K	SH3BP1_uc003atg.1_Intron|SH3BP1_uc003ath.1_Intron|SH3BP1_uc003atj.1_Intron|SH3BP1_uc003atk.1_Intron|uc003atl.1_Intron	NM_018957	NP_061830	Q9Y3L3	3BP1_HUMAN	SH3-domain binding protein 1	676					signal transduction	cytoplasm	GTPase activator activity|SH3 domain binding			central_nervous_system(1)	1	Melanoma(58;0.0574)					AGGAGCCCCTGAGGCTATCAG	0.667			NA											11	6					0	0	0.008291	0	0
KCNJ4	3761	broad.mit.edu	37	22	38823619	38823619	+	Silent	SNP	G	G	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr22:38823619G>T	uc003avs.1	-	2	616	c.519C>A	c.(517-519)GCC>GCA	p.A173A	KCNJ4_uc003avt.1_Silent_p.A173A	NM_004981	NP_004972	P48050	IRK4_HUMAN	potassium inwardly-rectifying channel J4	173	Cytoplasmic (By similarity).				synaptic transmission	basolateral plasma membrane|voltage-gated potassium channel complex	inward rectifier potassium channel activity|PDZ domain binding				0	Melanoma(58;0.0286)					GCGCCATCTTGGCCATGATGG	0.637			NA											4	93					0.00024832	0.000265313	0.009096	1	0
DDX17	10521	broad.mit.edu	37	22	38891885	38891885	+	Missense_Mutation	SNP	C	C	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr22:38891885C>A	uc003avy.3	-	6	899	c.796G>T	c.(796-798)GAC>TAC	p.D266Y	DDX17_uc003avx.3_Missense_Mutation_p.D266Y|DDX17_uc011anu.1_Missense_Mutation_p.D179Y	NM_001098504	NP_001091974	Q92841	DDX17_HUMAN	DEAD box polypeptide 17 isoform 3	187	Helicase ATP-binding.				RNA processing	nucleus	ATP binding|ATP-dependent helicase activity|RNA binding|RNA helicase activity|RNA-dependent ATPase activity			skin(3)|upper_aerodigestive_tract(1)	4	Melanoma(58;0.0286)					TTGCCATAGTCATCGGCCACC	0.438	Ovarian(55;1085 1454 6392 21425)		NA											18	106					5.03518e-11	6.27023e-11	0.007413	1	0
GTPBP1	9567	broad.mit.edu	37	22	39112972	39112972	+	Missense_Mutation	SNP	G	G	C			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr22:39112972G>C	uc003awg.2	+	4	955	c.801G>C	c.(799-801)ATG>ATC	p.M267I		NM_004286	NP_004277	O00178	GTPB1_HUMAN	GTP binding protein 1	267					immune response|positive regulation of mRNA catabolic process|signal transduction	cytoplasmic exosome (RNase complex)|cytosol	GTP binding|GTPase activity			ovary(1)	1	Melanoma(58;0.04)					TCTTCGGCATGACAGGCCATC	0.552			NA											10	90					0	0	0.006214	0	0
MGAT3	4248	broad.mit.edu	37	22	39884738	39884738	+	Silent	SNP	G	G	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr22:39884738G>T	uc003axv.3	+	2	1625	c.1386G>T	c.(1384-1386)GGG>GGT	p.G462G	MGAT3_uc010gxy.2_Silent_p.G462G	NM_002409	NP_002400	Q09327	MGAT3_HUMAN	mannosyl (beta-1,4-)-glycoprotein	462	Lumenal (Potential).				post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	beta-1,4-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity				0	Melanoma(58;0.04)					TCCGCACCGGGGGCTGGTTCG	0.627			NA											30	26					8.58068e-18	1.14409e-17	0.007291	1	0
ENTHD1	150350	broad.mit.edu	37	22	40140274	40140274	+	Missense_Mutation	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr22:40140274C>T	uc003ayg.2	-	7	1485	c.1234G>A	c.(1234-1236)GAG>AAG	p.E412K		NM_152512	NP_689725	Q8IYW4	ENTD1_HUMAN	ENTH domain containing 1	412										ovary(2)|skin(1)	3	Melanoma(58;0.0749)					GATGCTCCCTCAGAAGCAGTT	0.363			NA											3	13					0	0	0.004672	0	0
TNFRSF13C	115650	broad.mit.edu	37	22	42321443	42321443	+	Silent	SNP	G	G	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr22:42321443G>A	uc003bbl.2	-	3	527	c.483C>T	c.(481-483)GTC>GTT	p.V161V	WBP2NL_uc011ape.1_Intron|LOC339674_uc003bba.1_Intron|TNFRSF13C_uc010gyp.1_Silent_p.V162V	NM_052945	NP_443177	Q96RJ3	TR13C_HUMAN	BAFF receptor	161	Cytoplasmic (Potential).					integral to membrane	receptor activity				0						CTGGCACAGGGACACTGTGGC	0.637			NA											10	58					0	0	0.010729	0	0
SLC6A11	6538	broad.mit.edu	37	3	10967706	10967706	+	Silent	SNP	T	T	C			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr3:10967706T>C	uc003bvz.2	+	9	1171	c.1137T>C	c.(1135-1137)TTT>TTC	p.F379F		NM_014229	NP_055044	P48066	S6A11_HUMAN	solute carrier family 6 (neurotransmitter	379					neurotransmitter secretion	integral to plasma membrane	gamma-aminobutyric acid:sodium symporter activity|neurotransmitter:sodium symporter activity			skin(3)|ovary(1)	4				OV - Ovarian serous cystadenocarcinoma(96;0.229)		GCCTGGCCTTTATTGCGTACC	0.517			NA											87	291					0	0	0.01441	0	0
TSEN2	80746	broad.mit.edu	37	3	12558159	12558159	+	Missense_Mutation	SNP	A	A	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr3:12558159A>T	uc003bxc.2	+	7	1346	c.959A>T	c.(958-960)AAG>ATG	p.K320M	TSEN2_uc003bwy.2_Missense_Mutation_p.K320M|TSEN2_uc003bwz.2_Missense_Mutation_p.K261M|TSEN2_uc003bxa.2_Missense_Mutation_p.K294M|TSEN2_uc011auq.1_Missense_Mutation_p.K294M|TSEN2_uc003bxb.2_Missense_Mutation_p.K320M|TSEN2_uc011aur.1_Missense_Mutation_p.K229M	NM_025265	NP_079541	Q8NCE0	SEN2_HUMAN	tRNA-intron nuclease 2 isoform 1	320					mRNA processing|tRNA splicing, via endonucleolytic cleavage and ligation	cytoplasm|nucleolus|tRNA-intron endonuclease complex	nucleic acid binding|tRNA-intron endonuclease activity			central_nervous_system(1)	1						TACTATGAGAAGGTAAGATGC	0.318			NA											5	31					0	0	0.001984	0	0
COLQ	8292	broad.mit.edu	37	3	15495391	15495391	+	Missense_Mutation	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr3:15495391C>T	uc003bzx.2	-	16	1369	c.1243G>A	c.(1243-1245)GAG>AAG	p.E415K	COLQ_uc003bzv.2_Missense_Mutation_p.E405K|COLQ_uc003bzz.2_Missense_Mutation_p.E406K|COLQ_uc010heo.2_Missense_Mutation_p.E381K|COLQ_uc003cac.1_RNA|COLQ_uc003cae.1_Missense_Mutation_p.E274K|COLQ_uc003cad.1_RNA	NM_005677	NP_005668	Q9Y215	COLQ_HUMAN	acetylcholinesterase collagen-like tail subunit	415					acetylcholine catabolic process in synaptic cleft|asymmetric protein localization	basal lamina|cell junction|collagen|extracellular space|synaptic cleft					0						TCACAGTCCTCCACACCCTCA	0.483			NA											6	18					0	0	0.001984	0	0
PLCL2	23228	broad.mit.edu	37	3	17053070	17053070	+	Silent	SNP	A	A	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr3:17053070A>T	uc011awc.1	+	5	2313	c.2208A>T	c.(2206-2208)ACA>ACT	p.T736T	PLCL2_uc011awd.1_Silent_p.T618T	NM_001144382	NP_001137854	Q9UPR0	PLCL2_HUMAN	phospholipase C-like 2 isoform 1	744	C2.				intracellular signal transduction|lipid metabolic process	cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			skin(2)|ovary(1)|lung(1)	4						GCGCCAATACAAAAGACTCTG	0.507			NA											5	25					0	0	0.000602	0	0
ZNF860	344787	broad.mit.edu	37	3	32031984	32031984	+	Silent	SNP	T	T	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr3:32031984T>A	uc011axg.1	+	2	1962	c.1413T>A	c.(1411-1413)ATT>ATA	p.I471I		NM_001137674	NP_001131146	A6NHJ4	ZN860_HUMAN	zinc finger protein 860	471	C2H2-type 9.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						CCCTTGTAATTCATAAGGCAA	0.408			NA											6	24					0	0	0.001984	0	0
ARPP21	10777	broad.mit.edu	37	3	35778819	35778819	+	Missense_Mutation	SNP	C	C	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr3:35778819C>A	uc003cgb.2	+	16	1873	c.1609C>A	c.(1609-1611)CCG>ACG	p.P537T	ARPP21_uc003cga.2_Missense_Mutation_p.P483T|ARPP21_uc011axy.1_Missense_Mutation_p.P503T|ARPP21_uc003cgf.2_Missense_Mutation_p.P338T|ARPP21_uc003cgg.2_Missense_Mutation_p.P25T	NM_016300	NP_057384	Q9UBL0	ARP21_HUMAN	cyclic AMP-regulated phosphoprotein, 21 kD	537	Gln-rich.					cytoplasm	nucleic acid binding			ovary(2)|skin(1)	3						GGTCCAGCCACCGCAGCCACA	0.642			NA											10	37					3.86212e-05	4.21639e-05	0.008291	1	0
SCN10A	6336	broad.mit.edu	37	3	38770045	38770045	+	Silent	SNP	T	T	C			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr3:38770045T>C	uc003ciq.2	-	15	2628	c.2628A>G	c.(2626-2628)CTA>CTG	p.L876L		NM_006514	NP_006505	Q9Y5Y9	SCNAA_HUMAN	sodium channel, voltage-gated, type X, alpha	876	II.|Helical; Name=S6 of repeat II; (Potential).				sensory perception	voltage-gated sodium channel complex				ovary(5)|skin(3)|large_intestine(1)|kidney(1)	10				KIRC - Kidney renal clear cell carcinoma(284;0.0769)|Kidney(284;0.0945)	Benzocaine(DB01086)|Bupivacaine(DB00297)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dibucaine(DB00527)|Dyclonine(DB00645)|Hexylcaine(DB00473)|Levobupivacaine(DB01002)|Lidocaine(DB00281)|Mepivacaine(DB00961)|Oxybuprocaine(DB00892)|Procaine(DB00721)|Proparacaine(DB00807)|Ropivacaine(DB00296)	CCAGGTTCCCTAGCACCATCA	0.502			NA											6	38					0	0	0.001984	0	0
TTC21A	199223	broad.mit.edu	37	3	39161449	39161449	+	Nonsense_Mutation	SNP	G	G	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr3:39161449G>T	uc003cjc.2	+	8	1039	c.862G>T	c.(862-864)GAG>TAG	p.E288*	TTC21A_uc003cje.2_Nonsense_Mutation_p.E288*|TTC21A_uc003cjd.2_RNA|TTC21A_uc011ayx.1_Nonsense_Mutation_p.E239*	NM_145755	NP_665698	Q8NDW8	TT21A_HUMAN	tetratricopeptide repeat domain 21A isoform 2	288							binding			ovary(1)	1				KIRC - Kidney renal clear cell carcinoma(284;0.0588)|Kidney(284;0.0738)		TAAGGCACTAGAGACAAGGGA	0.428			NA											15	49					8.60227e-14	1.11224e-13	0.004007	1	0
CTNNB1	1499	broad.mit.edu	37	3	41266113	41266113	+	Missense_Mutation	SNP	C	C	G	rs121913403		TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr3:41266113C>G	uc010hia.1	+	4	266	c.110C>G	c.(109-111)TCT>TGT	p.S37C	CTNNB1_uc003ckp.2_Missense_Mutation_p.S37C|CTNNB1_uc003ckq.2_Missense_Mutation_p.S37C|CTNNB1_uc003ckr.2_Missense_Mutation_p.S37C|CTNNB1_uc011azf.1_Missense_Mutation_p.S30C|CTNNB1_uc011azg.1_Intron|uc010hib.1_RNA	NM_001904	NP_001895	P35222	CTNB1_HUMAN	beta-catenin	37			S -> C (in PTR, hepatoblastoma and ovarian cancer).|SG -> W (in hepatocellular carcinoma).|S -> F (in PTR).|S -> A (in MDB and hepatocellular carcinoma; enhances transactivation of target genes).|S -> Y (in hepatocellular carcinoma).		adherens junction assembly|androgen receptor signaling pathway|branching involved in ureteric bud morphogenesis|canonical Wnt receptor signaling pathway involved in negative regulation of apoptosis|canonical Wnt receptor signaling pathway involved in positive regulation of epithelial to mesenchymal transition|cell-cell adhesion|cell-matrix adhesion|cellular component disassembly involved in apoptosis|cellular response to growth factor stimulus|cellular response to indole-3-methanol|central nervous system vasculogenesis|cytoskeletal anchoring at plasma membrane|determination of dorsal/ventral asymmetry|dorsal/ventral axis specification|ectoderm development|embryonic axis specification|embryonic foregut morphogenesis|embryonic leg joint morphogenesis|endodermal cell fate commitment|endothelial tube morphogenesis|epithelial to mesenchymal transition|gastrulation with mouth forming second|glial cell fate determination|hair follicle morphogenesis|hair follicle placode formation|hindbrain development|liver development|lung cell differentiation|lung induction|lung-associated mesenchyme development|male genitalia development|mesenchymal cell proliferation involved in lung development|mesenchymal to epithelial transition involved in metanephros morphogenesis|negative regulation of cell proliferation|negative regulation of chondrocyte differentiation|negative regulation of heart induction by canonical Wnt receptor signaling pathway|negative regulation of osteoclast differentiation|negative regulation of transcription from RNA polymerase II promoter|nephron tubule formation|odontogenesis of dentine-containing tooth|oocyte development|pancreas development|positive regulation of anti-apoptosis|positive regulation of apoptosis|positive regulation of branching involved in lung morphogenesis|positive regulation of epithelial cell proliferation involved in prostate gland development|positive regulation of fibroblast growth factor receptor signaling pathway|positive regulation of heparan sulfate proteoglycan biosynthetic process|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of MAPKKK cascade|positive regulation of muscle cell differentiation|positive regulation of osteoblast differentiation|positive regulation of transcription from RNA polymerase II promoter|protein localization at cell surface|proximal/distal pattern formation|regulation of angiogenesis|regulation of calcium ion import|regulation of centriole-centriole cohesion|regulation of centromeric sister chromatid cohesion|regulation of fibroblast proliferation|regulation of nephron tubule epithelial cell differentiation|regulation of protein localization at cell surface|regulation of smooth muscle cell proliferation|regulation of T cell proliferation|renal inner medulla development|renal outer medulla development|renal vesicle formation|response to drug|response to estradiol stimulus|Schwann cell proliferation|smooth muscle cell differentiation|synapse organization|synaptic vesicle transport|T cell differentiation in thymus|thymus development|trachea formation	APC-Axin-1-beta-catenin complex|Axin-APC-beta-catenin-GSK3B complex|beta-catenin-TCF7L2 complex|catenin complex|cell cortex|cell-substrate adherens junction|centrosome|dendritic shaft|desmosome|fascia adherens|internal side of plasma membrane|lamellipodium|lateral plasma membrane|microvillus membrane|perinuclear region of cytoplasm|protein-DNA complex|synapse|transcription factor complex|Z disc|zonula adherens	alpha-catenin binding|androgen receptor binding|cadherin binding|estrogen receptor binding|I-SMAD binding|ion channel binding|protein binding|protein C-terminus binding|protein kinase binding|protein phosphatase binding|R-SMAD binding|RPTP-like protein binding|signal transducer activity|specific RNA polymerase II transcription factor activity|structural molecule activity|transcription coactivator activity|transcription regulatory region DNA binding	p.S37F(147)|p.S37C(124)|p.A5_A80del(63)|p.S37A(59)|p.S37Y(23)|p.S37P(16)|p.H24_S47del(9)|p.A5_A80>D(7)|p.A5_Q143del(7)|p.Q28_H134del(5)|p.W25_I140del(4)|p.V22_G38del(3)|p.T3_A126del(2)|p.M5_N141>D(2)|p.D32_S47del(2)|p.V22_L139>V(2)|p.A5_Y142>D(2)|p.A5fs*7(2)|p.?(2)|p.L10_N141del(2)|p.D6_A43del(1)|p.E9_S47del(1)|p.Q28_Q61del(1)|p.A20_R151del(1)|p.A20_N141del(1)|p.D11_Y142>H(1)|p.H24_G38del(1)|p.Y30_A97del(1)|p.A20_A80del(1)|p.Q28_A43del(1)|p.E15_I140>V(1)|p.D17_P128del(1)|p.H24_M131del(1)|p.L7_I140del(1)|p.K19_Y142>V(1)|p.A20_L148del(1)|p.V22_A80del(1)|p.V22_G80>NNNNN(1)|p.GIHS34?(1)|p.A20_Q143del(1)|p.A13_R151del(1)|p.S23_I140del(1)|p.M1_A87del(1)|p.V22_T102del(1)|p.S23_A39del(1)|p.A21_A80del(1)|p.P16_K133del(1)|p.D6_I140del(1)|p.Q28_I140del(1)|p.E9_A80del(1)|p.G34_S37del(1)|p.I35_S37>T(1)|p.I35_K170del(1)|p.M14_S45del(1)|p.M8_G50del(1)|p.A5_G80>(1)|p.S37S(1)|p.S37T(1)|p.V22_S71>A(1)|p.A5_T59del(1)|p.M1_V173del(1)|p.A5_R90del(1)|p.V22_Y64del(1)|p.M8_A80del(1)|p.S33_S37del(1)|p.E9_I140del(1)|p.Y30_T40del(1)|p.M1_T42del(1)|p.S37_G38>W(1)|p.A5_Q143>E(1)|p.I35_G38del(1)|p.H36_E53>L(1)|p.A5_Q72del(1)|p.Y30_A80del(1)|p.D32fs*9(1)|p.S37_A39>S(1)|p.D6_K133del(1)|p.A5_T42del(1)|p.A5_D144>D(1)|p.A5_T40del(1)|p.D17_A126del(1)|p.A5_E54del(1)|p.I35_T41del(1)|p.W25_A80del(1)|p.A20_Q72del(1)|p.A20_S111del(1)	CTNNB1/PLAG1(60)	liver(806)|soft_tissue(609)|large_intestine(243)|endometrium(222)|kidney(172)|stomach(157)|central_nervous_system(139)|ovary(104)|skin(97)|pancreas(91)|adrenal_gland(85)|pituitary(81)|salivary_gland(62)|haematopoietic_and_lymphoid_tissue(57)|thyroid(55)|biliary_tract(41)|lung(38)|prostate(24)|bone(20)|small_intestine(17)|cervix(9)|parathyroid(9)|urinary_tract(8)|breast(7)|oesophagus(5)|NS(3)|pleura(2)|upper_aerodigestive_tract(2)|eye(1)	3166				KIRC - Kidney renal clear cell carcinoma(284;0.0028)|Kidney(284;0.00294)	Lithium(DB01356)	GGAATCCATTCTGGTGCCACT	0.498	Colon(6;3 56 14213 18255)	S37F(HUTU80_SMALL_INTESTINE)|S37C(SNU398_LIVER)|S37C(JHUEM2_ENDOMETRIUM)	15	H|Mis|T	PLAG1	colorectal|cvarian| hepatoblastoma|others|pleomorphic salivary adenoma				Pilomatrixoma_Familial_Clustering_of				5	15					0	0	0.000602	0	0
NKTR	4820	broad.mit.edu	37	3	42680905	42680905	+	Missense_Mutation	SNP	G	G	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr3:42680905G>T	uc003clo.2	+	13	3856	c.3709G>T	c.(3709-3711)GCA>TCA	p.A1237S	NKTR_uc003clm.1_Missense_Mutation_p.A984S|NKTR_uc003clp.2_Missense_Mutation_p.A984S|NKTR_uc011azp.1_Intron|NKTR_uc003clq.1_Missense_Mutation_p.A1127S|NKTR_uc003clr.1_Missense_Mutation_p.A984S|NKTR_uc003cls.2_Missense_Mutation_p.A937S	NM_005385	NP_005376	P30414	NKTR_HUMAN	natural killer-tumor recognition sequence	1237					protein folding	membrane	cyclosporin A binding|peptidyl-prolyl cis-trans isomerase activity			ovary(2)|skin(1)	3				KIRC - Kidney renal clear cell carcinoma(284;0.24)		GAACCTGGCAGCACCTAATGC	0.478			NA											9	46					1.04858e-14	1.36795e-14	0.006214	1	0
TDGF1	6997	broad.mit.edu	37	3	46620584	46620584	+	Splice_Site	SNP	G	G	C			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr3:46620584G>C	uc003cpv.2	+	2	316	c.36_splice	c.e2-1	p.S12_splice	LRRC2_uc003cpu.3_Intron	NM_003212	NP_003203	P13385	TDGF1_HUMAN	teratocarcinoma-derived growth factor 1						activation of MAPK activity|anterior/posterior axis specification, embryo|mammary gland development|morphogenesis of a branching structure|negative regulation of apoptosis|peptidyl-serine phosphorylation|positive regulation of cell migration|positive regulation of peptidyl-tyrosine phosphorylation	anchored to membrane|cell surface|extrinsic to plasma membrane	growth factor activity				0				BRCA - Breast invasive adenocarcinoma(193;0.00114)|KIRC - Kidney renal clear cell carcinoma(197;0.0173)|Kidney(197;0.0204)		CCTCTTCCTAGTGTGATTTGG	0.413			NA											17	65					0	0	0.006122	0	0
TREX1	11277	broad.mit.edu	37	3	48508518	48508518	+	Missense_Mutation	SNP	G	G	C			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr3:48508518G>C	uc003ctj.2	+	2	1886	c.629G>C	c.(628-630)AGC>ACC	p.S210T	TREX1_uc010hjy.2_Missense_Mutation_p.S155T|TREX1_uc003ctk.2_Missense_Mutation_p.S16T|TREX1_uc010hjz.2_Missense_Mutation_p.S155T|TREX1_uc010hka.2_Missense_Mutation_p.S210T	NM_033629	NP_338599	Q9NSU2	TREX1_HUMAN	three prime repair exonuclease 1 isoform b	210					cell death|DNA recombination|DNA replication|mismatch repair	nuclear envelope	3'-5'-exodeoxyribonuclease activity|exodeoxyribonuclease III activity|metal ion binding|MutLalpha complex binding|MutSalpha complex binding|protein homodimerization activity|single-stranded DNA binding				0				BRCA - Breast invasive adenocarcinoma(193;0.000286)|KIRC - Kidney renal clear cell carcinoma(197;0.00544)|Kidney(197;0.00605)		TGTGTGGATAGCATCACTGCG	0.602			NA						Direct_reversal_of_damage|Editing_and_processing_nucleases					11	68					0	0	0.010729	0	0
APEH	327	broad.mit.edu	37	3	49720763	49720763	+	Missense_Mutation	SNP	C	C	G			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr3:49720763C>G	uc003cxf.2	+	22	2587	c.2187C>G	c.(2185-2187)CAC>CAG	p.H729Q	APEH_uc010hkw.1_Missense_Mutation_p.H734Q	NM_001640	NP_001631	P13798	ACPH_HUMAN	N-acylaminoacyl-peptide hydrolase	729					proteolysis	cytoplasm|nuclear membrane	serine-type endopeptidase activity			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;4.53e-05)|Kidney(197;0.00218)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)		TACGCACACACTTGGGCAGCT	0.567			NA											20	105					0	0	0.010504	0	0
CAMKV	79012	broad.mit.edu	37	3	49897671	49897671	+	Missense_Mutation	SNP	G	G	C			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr3:49897671G>C	uc003cxt.1	-	10	1068	c.875C>G	c.(874-876)TCT>TGT	p.S292C	CAMKV_uc011bcy.1_Missense_Mutation_p.S217C|CAMKV_uc003cxv.1_Missense_Mutation_p.S264C|CAMKV_uc003cxw.1_Missense_Mutation_p.S124C|CAMKV_uc003cxx.1_Missense_Mutation_p.S124C|CAMKV_uc003cxu.2_Missense_Mutation_p.S292C|CAMKV_uc011bcz.1_Missense_Mutation_p.S255C|CAMKV_uc011bda.1_Missense_Mutation_p.S249C|CAMKV_uc011bdb.1_RNA	NM_024046	NP_076951	Q8NCB2	CAMKV_HUMAN	CaM kinase-like vesicle-associated	292						cytoplasmic vesicle membrane|plasma membrane	ATP binding|protein serine/threonine kinase activity			ovary(2)|lung(2)|large_intestine(2)|central_nervous_system(1)	7				BRCA - Breast invasive adenocarcinoma(193;4.62e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.00551)|Kidney(197;0.00621)		GTTCTTATCAGAAGCAGCATT	0.488			NA											13	36					0	0	0.013537	0	0
GNAT1	2779	broad.mit.edu	37	3	50230588	50230588	+	Silent	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr3:50230588C>T	uc003cym.2	+	2	245	c.129C>T	c.(127-129)AGC>AGT	p.S43S	GNAT1_uc003cyl.2_Silent_p.S43S	NM_144499	NP_653082	P11488	GNAT1_HUMAN	rod-type transducin alpha subunit	43	GTP (By similarity).	Magnesium (By similarity).			detection of chemical stimulus involved in sensory perception of bitter taste|G-protein signaling, coupled to cAMP nucleotide second messenger|negative regulation of cyclic-nucleotide phosphodiesterase activity|rhodopsin mediated phototransduction|sensory perception of umami taste	heterotrimeric G-protein complex|photoreceptor inner segment|photoreceptor outer segment membrane	acyl binding|G-protein beta/gamma-subunit complex binding|G-protein-coupled receptor binding|GDP binding|GTP binding|GTPase activity|protein kinase binding|signal transducer activity			ovary(1)|central_nervous_system(1)|pancreas(1)	3				BRCA - Breast invasive adenocarcinoma(193;0.000272)|KIRC - Kidney renal clear cell carcinoma(197;0.00544)|Kidney(197;0.00605)		CCGGGAAGAGCACCATCGTCA	0.662			NA									OREG0015579	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	7	56					0	0	0.00308	0	0
DOCK3	1795	broad.mit.edu	37	3	51392312	51392312	+	Splice_Site	SNP	G	G	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr3:51392312G>A	uc011bds.1	+	41	4131	c.4108_splice	c.e41-1	p.N1370_splice		NM_004947	NP_004938	Q8IZD9	DOCK3_HUMAN	dedicator of cytokinesis 3							cytoplasm	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity|SH3 domain binding				0				BRCA - Breast invasive adenocarcinoma(193;0.00105)|KIRC - Kidney renal clear cell carcinoma(197;0.00449)|Kidney(197;0.00518)		GTTTGTGGCAGAACAAAGAAT	0.502			NA											26	92					0	0	0.005443	0	0
RAD54L2	23132	broad.mit.edu	37	3	51663464	51663464	+	Silent	SNP	T	T	C			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr3:51663464T>C	uc011bdt.1	+	4	581	c.456T>C	c.(454-456)CCT>CCC	p.P152P	RAD54L2_uc003dbh.2_5'UTR|RAD54L2_uc011bdu.1_5'UTR|RAD54L2_uc003dbj.2_5'Flank	NM_015106	NP_055921	Q9Y4B4	ARIP4_HUMAN	RAD54-like 2	152						nucleus	ATP binding|DNA binding|helicase activity			ovary(3)	3				BRCA - Breast invasive adenocarcinoma(193;0.000102)|Kidney(197;0.000758)|KIRC - Kidney renal clear cell carcinoma(197;0.000896)		CCCCTATTCCTACTGTTCCGC	0.527			NA											3	14					0	0	0.004672	0	0
TLR9	54106	broad.mit.edu	37	3	52257047	52257047	+	Nonsense_Mutation	SNP	C	C	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr3:52257047C>A	uc003dda.1	-	2	1919	c.1285G>T	c.(1285-1287)GGA>TGA	p.G429*	TLR9_uc003ddb.2_Nonsense_Mutation_p.G526*	NM_017442	NP_059138	Q9NR96	TLR9_HUMAN	toll-like receptor 9 isoform A precursor	429	LRR 14.|Extracellular (Potential).				defense response to bacterium|fibroblast growth factor receptor signaling pathway|I-kappaB phosphorylation|inflammatory response|innate immune response|insulin receptor signaling pathway|maintenance of gastrointestinal epithelium|negative regulation of interleukin-6 production|negative regulation of interleukin-8 production|negative regulation of NF-kappaB transcription factor activity|negative regulation of toll-like receptor signaling pathway|positive regulation of chemokine production|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interferon-alpha biosynthetic process|positive regulation of interferon-beta biosynthetic process|positive regulation of interferon-beta production|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-10 production|positive regulation of interleukin-12 production|positive regulation of interleukin-18 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of JUN kinase activity|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of toll-like receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|response to molecule of bacterial origin	apical plasma membrane|basolateral plasma membrane|early phagosome|endoplasmic reticulum membrane|endosome membrane|extracellular region|integral to membrane|lysosome	interleukin-1 receptor binding|siRNA binding|transmembrane receptor activity			large_intestine(2)|skin(2)	4				BRCA - Breast invasive adenocarcinoma(193;2.41e-05)|Kidney(197;0.000537)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)	Chloroquine(DB00608)	TCCGAAGCTCCGCTGATGCGG	0.642			NA											46	141					3.86361e-14	5.00889e-14	0.01441	1	0
GLYCTK	132158	broad.mit.edu	37	3	52324415	52324415	+	Silent	SNP	C	C	G			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr3:52324415C>G	uc003ddo.2	+	2	153	c.57C>G	c.(55-57)CTC>CTG	p.L19L	GLYCTK_uc003ddq.2_Silent_p.L19L|GLYCTK_uc003ddm.2_Intron|GLYCTK_uc003ddn.2_RNA|GLYCTK_uc003ddp.1_Silent_p.L19L|GLYCTK_uc003ddr.2_5'Flank	NM_145262	NP_660305	Q8IVS8	GLCTK_HUMAN	glycerate kinase isoform 1	19					protein phosphorylation	Golgi apparatus|mitochondrion	ATP binding|glycerate kinase activity|protein binding				0				BRCA - Breast invasive adenocarcinoma(193;3.56e-05)|Kidney(197;0.00171)|KIRC - Kidney renal clear cell carcinoma(197;0.00194)|OV - Ovarian serous cystadenocarcinoma(275;0.235)		TGCATCCACTCCTCTGGCGGG	0.682			NA											9	30					0	0	0.006214	0	0
DNAH1	25981	broad.mit.edu	37	3	52429689	52429689	+	Missense_Mutation	SNP	G	G	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr3:52429689G>T	uc011bef.1	+	70	11515	c.11254G>T	c.(11254-11256)GAC>TAC	p.D3752Y	DNAH1_uc003ddv.2_Missense_Mutation_p.D610Y	NM_015512	NP_056327	Q9P2D7	DYH1_HUMAN	dynein, axonemal, heavy chain 1	3817	AAA 6 (By similarity).				ciliary or flagellar motility|microtubule-based movement|response to mechanical stimulus	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			large_intestine(3)	3				BRCA - Breast invasive adenocarcinoma(193;2.02e-05)|OV - Ovarian serous cystadenocarcinoma(275;0.000207)|Kidney(197;0.0022)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		CATCAACCCCGACAAGGTGTG	0.488			NA											5	15					1.23904e-05	1.37125e-05	0.000602	1	0
ACTR8	93973	broad.mit.edu	37	3	53908248	53908248	+	Missense_Mutation	SNP	T	T	C			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr3:53908248T>C	uc003dhd.2	-	8	1114	c.1055A>G	c.(1054-1056)CAT>CGT	p.H352R	ACTR8_uc003dhb.2_Intron|ACTR8_uc003dhc.2_Missense_Mutation_p.H241R	NM_022899	NP_075050	Q9H981	ARP8_HUMAN	actin-related protein 8	352					cell division|DNA recombination|DNA repair|mitosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	Ino80 complex	protein binding			ovary(1)|central_nervous_system(1)	2				BRCA - Breast invasive adenocarcinoma(193;0.000143)|KIRC - Kidney renal clear cell carcinoma(284;0.00544)|Kidney(284;0.00607)|OV - Ovarian serous cystadenocarcinoma(275;0.111)		CTGATCTAAATGACAAAAAGT	0.328			NA											5	26					0	0	0.000602	0	0
FLNB	2317	broad.mit.edu	37	3	58116633	58116633	+	Missense_Mutation	SNP	G	G	C			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr3:58116633G>C	uc003djj.2	+	25	4553	c.4388G>C	c.(4387-4389)CGA>CCA	p.R1463P	FLNB_uc010hne.2_Missense_Mutation_p.R1463P|FLNB_uc003djk.2_Missense_Mutation_p.R1463P|FLNB_uc010hnf.2_Missense_Mutation_p.R1463P|FLNB_uc003djl.2_Missense_Mutation_p.R1294P|FLNB_uc003djm.2_Missense_Mutation_p.R1294P	NM_001457	NP_001448	O75369	FLNB_HUMAN	filamin B isoform 2	1463	Filamin 13.|Interaction with FBLP1.				actin cytoskeleton organization|cell differentiation|cytoskeletal anchoring at plasma membrane|signal transduction	cell cortex|integral to membrane|nucleus|sarcomere	actin binding			breast(8)|ovary(5)|lung(3)|skin(2)|central_nervous_system(1)	19				BRCA - Breast invasive adenocarcinoma(55;0.000335)|KIRC - Kidney renal clear cell carcinoma(284;0.0726)|Kidney(284;0.0898)		CTGGGCCCACGAGGTAAGTGT	0.617			NA											9	19					0	0	0.004482	0	0
CHMP2B	25978	broad.mit.edu	37	3	87302615	87302615	+	Silent	SNP	T	T	C			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr3:87302615T>C	uc003dqp.3	+	5	746	c.486T>C	c.(484-486)ATT>ATC	p.I162I	CHMP2B_uc011bgn.1_Silent_p.I121I	NM_014043	NP_054762	Q9UQN3	CHM2B_HUMAN	chromatin modifying protein 2B	162					cellular membrane organization|endosome transport|protein transport	cytosol|late endosome membrane|mitochondrion|nucleus	protein domain specific binding			skin(2)|ovary(1)	3	all_cancers(8;0.104)|Lung SC(3;0.184)	Lung NSC(201;0.0777)		LUSC - Lung squamous cell carcinoma(29;0.00241)|Lung(72;0.00712)		GCCAGGATATTGTGAATCAAG	0.378			NA											3	19					0	0	0.004672	0	0
EPHA3	2042	broad.mit.edu	37	3	89528582	89528582	+	Missense_Mutation	SNP	C	C	G			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr3:89528582C>G	uc003dqy.2	+	17	3107	c.2882C>G	c.(2881-2883)CCA>CGA	p.P961R	EPHA3_uc010hon.1_RNA	NM_005233	NP_005224	P29320	EPHA3_HUMAN	ephrin receptor EphA3 isoform a precursor	961	Cytoplasmic (Potential).|SAM.					extracellular region|integral to plasma membrane	ATP binding			lung(17)|ovary(7)|large_intestine(4)|central_nervous_system(2)|stomach(1)|skin(1)|pancreas(1)	33	all_cancers(8;0.0406)|Melanoma(1;0.00142)|all_epithelial(1;0.0612)	Lung NSC(201;0.0782)		LUSC - Lung squamous cell carcinoma(29;0.00344)|Lung(72;0.00942)		GTGGTTGGGCCACAGAAGAAG	0.428			NA								TSP Lung(6;0.00050)			4	24					0	0	0.009096	0	0
PROS1	5627	broad.mit.edu	37	3	93646105	93646105	+	Missense_Mutation	SNP	C	C	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr3:93646105C>A	uc003drb.3	-	2	564	c.223G>T	c.(223-225)GAC>TAC	p.D75Y	PROS1_uc010hoo.2_5'UTR|PROS1_uc003dqz.3_5'UTR	NM_000313	NP_000304	P07225	PROS_HUMAN	protein S, alpha preproprotein	75	Gla.				leukocyte migration|peptidyl-glutamic acid carboxylation|platelet activation|platelet degranulation|post-translational protein modification|proteolysis	endoplasmic reticulum membrane|extracellular region|Golgi lumen|Golgi membrane|platelet alpha granule lumen	calcium ion binding|endopeptidase inhibitor activity			large_intestine(1)	1					Antihemophilic Factor(DB00025)|Drotrecogin alfa(DB00055)|Menadione(DB00170)	GTTTCCGGGTCATTTTCAAAG	0.393			NA											15	116					6.33239e-15	8.27599e-15	0.010504	1	0
EPHA6	285220	broad.mit.edu	37	3	96706570	96706570	+	Missense_Mutation	SNP	C	C	G			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr3:96706570C>G	uc010how.1	+	3	890	c.847C>G	c.(847-849)CAA>GAA	p.Q283E	EPHA6_uc003drp.1_Missense_Mutation_p.Q283E	NM_001080448	NP_001073917	Q9UF33	EPHA6_HUMAN	EPH receptor A6 isoform a	188	Ephrin-binding.|Extracellular (Potential).					integral to plasma membrane	ATP binding|ephrin receptor activity			stomach(5)|lung(4)|central_nervous_system(3)|breast(1)|skin(1)|ovary(1)|kidney(1)	16						TCTGGCTTTTCAAGACATTGG	0.458			NA											83	88					0	0	0.01441	0	0
SENP7	57337	broad.mit.edu	37	3	101056447	101056447	+	Missense_Mutation	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr3:101056447C>T	uc003dut.2	-	17	2497	c.2386G>A	c.(2386-2388)GAA>AAA	p.E796K	SENP7_uc003duu.2_Missense_Mutation_p.E731K|SENP7_uc003duv.2_Missense_Mutation_p.E763K|SENP7_uc003duw.2_Missense_Mutation_p.E730K|SENP7_uc003dux.2_Missense_Mutation_p.E632K	NM_020654	NP_065705	Q9BQF6	SENP7_HUMAN	sentrin/SUMO-specific protease 7 isoform 1	796	Protease.				proteolysis	nucleus	cysteine-type peptidase activity			ovary(3)|lung(2)	5						TCAACAAGTTCATCTGATGCC	0.318			NA											6	47					0	0	0.001168	0	0
MORC1	27136	broad.mit.edu	37	3	108778673	108778673	+	Silent	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr3:108778673C>T	uc003dxl.2	-	12	1098	c.1011G>A	c.(1009-1011)AAG>AAA	p.K337K	MORC1_uc011bhn.1_Silent_p.K337K	NM_014429	NP_055244	Q86VD1	MORC1_HUMAN	MORC family CW-type zinc finger 1	337	Potential.				cell differentiation|multicellular organismal development|spermatogenesis	nucleus	ATP binding|zinc ion binding			ovary(3)|skin(3)|breast(2)	8						CTTTAAGATTCTTTTGCTTTG	0.363			NA											6	11					0	0	0.001984	0	0
PHLDB2	90102	broad.mit.edu	37	3	111603514	111603514	+	Missense_Mutation	SNP	G	G	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr3:111603514G>A	uc010hqa.2	+	2	1001	c.590G>A	c.(589-591)GGA>GAA	p.G197E	PHLDB2_uc003dyc.2_Missense_Mutation_p.G224E|PHLDB2_uc003dyd.2_Missense_Mutation_p.G197E|PHLDB2_uc003dyg.2_Missense_Mutation_p.G197E|PHLDB2_uc003dyh.2_Missense_Mutation_p.G197E|PHLDB2_uc003dye.3_Missense_Mutation_p.G197E|PHLDB2_uc003dyf.3_Missense_Mutation_p.G197E	NM_001134438	NP_001127910	Q86SQ0	PHLB2_HUMAN	pleckstrin homology-like domain, family B,	197						cytoplasm|intermediate filament cytoskeleton|plasma membrane				ovary(4)|skin(2)	6						AGCAGATCGGGAGCCGCAAGC	0.567			NA											6	31					0	0	0.001168	0	0
QTRTD1	79691	broad.mit.edu	37	3	113798781	113798781	+	Missense_Mutation	SNP	G	G	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr3:113798781G>A	uc003eay.2	+	8	1005	c.775G>A	c.(775-777)GAG>AAG	p.E259K	QTRTD1_uc003eaz.2_Missense_Mutation_p.E271K|QTRTD1_uc011biq.1_Missense_Mutation_p.E136K|QTRTD1_uc011bir.1_Missense_Mutation_p.E153K	NM_024638	NP_078914	Q9H974	QTRD1_HUMAN	queuine tRNA-ribosyltransferase domain	259					queuosine biosynthetic process	mitochondrion	metal ion binding|queuine tRNA-ribosyltransferase activity			central_nervous_system(1)|skin(1)	2						TCGGCCAGATGAGGTGCTCGA	0.408			NA											15	125					0	0	0.00499	0	0
DRD3	1814	broad.mit.edu	37	3	113866313	113866313	+	Missense_Mutation	SNP	C	C	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr3:113866313C>A	uc003ebd.2	-	5	898	c.475G>T	c.(475-477)GTA>TTA	p.V159L	DRD3_uc010hqn.1_Missense_Mutation_p.V159L|DRD3_uc003ebb.1_Missense_Mutation_p.V159L|DRD3_uc003ebc.1_Missense_Mutation_p.V159L	NM_000796	NP_000787	P35462	DRD3_HUMAN	dopamine receptor D3 isoform a	159	Helical; Name=4.				activation of adenylate cyclase activity by dopamine receptor signaling pathway|arachidonic acid secretion|behavioral response to cocaine|cellular calcium ion homeostasis|circadian regulation of gene expression|G-protein coupled receptor internalization|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|locomotory behavior|musculoskeletal movement, spinal reflex action|negative regulation of blood pressure|negative regulation of oligodendrocyte differentiation|negative regulation of protein kinase B signaling cascade|negative regulation of protein secretion|positive regulation of dopamine receptor signaling pathway|positive regulation of mitosis|prepulse inhibition|regulation of dopamine secretion|response to drug|response to histamine|response to morphine|social behavior|visual learning	integral to plasma membrane	dopamine D3 receptor activity|drug binding			ovary(1)|pancreas(1)|central_nervous_system(1)|skin(1)	4					Apomorphine(DB00714)|Chlorprothixene(DB01239)|Cocaine(DB00907)|Methotrimeprazine(DB01403)|Olanzapine(DB00334)|Pramipexole(DB00413)|Ropinirole(DB00268)|Ziprasidone(DB00246)	AAGGCCAGTACCCAGACGGCC	0.542			NA											75	69					2.18329e-32	3.05408e-32	0.01441	1	0
DRD3	1814	broad.mit.edu	37	3	113890706	113890706	+	Missense_Mutation	SNP	A	A	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr3:113890706A>T	uc003ebd.2	-	3	557	c.134T>A	c.(133-135)TTC>TAC	p.F45Y	DRD3_uc010hqn.1_Missense_Mutation_p.F45Y|DRD3_uc003ebb.1_Missense_Mutation_p.F45Y|DRD3_uc003ebc.1_Missense_Mutation_p.F45Y	NM_000796	NP_000787	P35462	DRD3_HUMAN	dopamine receptor D3 isoform a	45	Helical; Name=1.				activation of adenylate cyclase activity by dopamine receptor signaling pathway|arachidonic acid secretion|behavioral response to cocaine|cellular calcium ion homeostasis|circadian regulation of gene expression|G-protein coupled receptor internalization|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|locomotory behavior|musculoskeletal movement, spinal reflex action|negative regulation of blood pressure|negative regulation of oligodendrocyte differentiation|negative regulation of protein kinase B signaling cascade|negative regulation of protein secretion|positive regulation of dopamine receptor signaling pathway|positive regulation of mitosis|prepulse inhibition|regulation of dopamine secretion|response to drug|response to histamine|response to morphine|social behavior|visual learning	integral to plasma membrane	dopamine D3 receptor activity|drug binding			ovary(1)|pancreas(1)|central_nervous_system(1)|skin(1)	4					Apomorphine(DB00714)|Chlorprothixene(DB01239)|Cocaine(DB00907)|Methotrimeprazine(DB01403)|Olanzapine(DB00334)|Pramipexole(DB00413)|Ropinirole(DB00268)|Ziprasidone(DB00246)	GCCATTGCCGAAGACGATGGC	0.607			NA											10	108					0	0	0.006214	0	0
HGD	3081	broad.mit.edu	37	3	120352002	120352002	+	Missense_Mutation	SNP	C	C	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr3:120352002C>A	uc003edw.2	-	13	1550	c.1180G>T	c.(1180-1182)GGC>TGC	p.G394C	HGD_uc003edv.2_Missense_Mutation_p.G253C	NM_000187	NP_000178	Q93099	HGD_HUMAN	homogentisate 1,2-dioxygenase	394					L-phenylalanine catabolic process|tyrosine catabolic process	cytosol	homogentisate 1,2-dioxygenase activity|metal ion binding				0				GBM - Glioblastoma multiforme(114;0.158)		ACCATGGTGCCATCGGCAATC	0.542			NA											7	31					2.7689e-08	3.30356e-08	0.001984	1	0
GOLGB1	2804	broad.mit.edu	37	3	121417151	121417151	+	Missense_Mutation	SNP	T	T	C			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr3:121417151T>C	uc003eei.3	-	13	2330	c.2204A>G	c.(2203-2205)AAC>AGC	p.N735S	GOLGB1_uc010hrc.2_Missense_Mutation_p.N740S|GOLGB1_uc003eej.3_Missense_Mutation_p.N701S|GOLGB1_uc011bjm.1_Missense_Mutation_p.N621S|GOLGB1_uc010hrd.1_Missense_Mutation_p.N699S	NM_004487	NP_004478	Q14789	GOGB1_HUMAN	golgi autoantigen, golgin subfamily b,	735	Cytoplasmic (Potential).|Potential.				Golgi organization	ER-Golgi intermediate compartment|Golgi membrane|Golgi stack|integral to membrane	protein binding			ovary(6)|breast(2)|skin(2)	10				GBM - Glioblastoma multiforme(114;0.0989)		TGCACTGCTGTTGTTGTCAGC	0.388			NA											12	38					0	0	0.010729	0	0
SEMA5B	54437	broad.mit.edu	37	3	122630855	122630855	+	Missense_Mutation	SNP	G	G	C			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr3:122630855G>C	uc003efz.1	-	20	3262	c.2958C>G	c.(2956-2958)AGC>AGG	p.S986R	SEMA5B_uc011bju.1_Missense_Mutation_p.S892R|SEMA5B_uc003ega.1_RNA|SEMA5B_uc003egb.1_Missense_Mutation_p.S986R|SEMA5B_uc003efy.1_5'UTR	NM_001031702	NP_001026872	Q9P283	SEM5B_HUMAN	semaphorin 5B isoform 1	986	Extracellular (Potential).|TSP type-1 5.				cell differentiation|nervous system development	integral to membrane	receptor activity			ovary(2)|breast(2)|pancreas(2)|central_nervous_system(1)	7				GBM - Glioblastoma multiforme(114;0.0367)		CACAGTGCCGGCTTCGGCTCT	0.637			NA											13	26					0	0	0.001855	0	0
KALRN	8997	broad.mit.edu	37	3	124103792	124103792	+	Missense_Mutation	SNP	T	T	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr3:124103792T>A	uc003ehg.2	+	11	1992	c.1865T>A	c.(1864-1866)CTG>CAG	p.L622Q	KALRN_uc010hrv.1_Missense_Mutation_p.L622Q|KALRN_uc003ehf.1_Missense_Mutation_p.L622Q|KALRN_uc011bjy.1_Missense_Mutation_p.L622Q|KALRN_uc003ehh.1_5'UTR	NM_001024660	NP_001019831	O60229	KALRN_HUMAN	kalirin, RhoGEF kinase isoform 1	622	Spectrin 3.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|vesicle-mediated transport	actin cytoskeleton|cytosol	ATP binding|GTPase activator activity|metal ion binding|protein binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			large_intestine(2)|ovary(2)|central_nervous_system(1)|skin(1)	6						GCTCGACACCTGGAGGTGCGC	0.562			NA											21	46					0	0	0.008871	0	0
KALRN	8997	broad.mit.edu	37	3	124398361	124398361	+	Missense_Mutation	SNP	G	G	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr3:124398361G>A	uc003ehg.2	+	51	7501	c.7374G>A	c.(7372-7374)ATG>ATA	p.M2458I	KALRN_uc003ehk.2_Missense_Mutation_p.M761I	NM_001024660	NP_001019831	O60229	KALRN_HUMAN	kalirin, RhoGEF kinase isoform 1	2457					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|vesicle-mediated transport	actin cytoskeleton|cytosol	ATP binding|GTPase activator activity|metal ion binding|protein binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			large_intestine(2)|ovary(2)|central_nervous_system(1)|skin(1)	6						ATACTAGCATGGAGGTAGAAG	0.428			NA											13	58					0	0	0.013537	0	0
KALRN	8997	broad.mit.edu	37	3	124431933	124431933	+	Missense_Mutation	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr3:124431933C>T	uc003ehg.2	+	58	8354	c.8227C>T	c.(8227-8229)CTC>TTC	p.L2743F	KALRN_uc003ehk.2_Missense_Mutation_p.L1046F	NM_001024660	NP_001019831	O60229	KALRN_HUMAN	kalirin, RhoGEF kinase isoform 1	2742	Protein kinase.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|vesicle-mediated transport	actin cytoskeleton|cytosol	ATP binding|GTPase activator activity|metal ion binding|protein binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			large_intestine(2)|ovary(2)|central_nervous_system(1)|skin(1)	6						GTACATCACTCTCCATGACAC	0.488			NA											9	29					0	0	0.004482	0	0
OSBPL11	114885	broad.mit.edu	37	3	125286264	125286264	+	Nonsense_Mutation	SNP	G	G	C			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr3:125286264G>C	uc003eic.2	-	6	1579	c.842C>G	c.(841-843)TCA>TGA	p.S281*		NM_022776	NP_073613	Q9BXB4	OSB11_HUMAN	oxysterol binding protein-like 11	281					lipid transport		lipid binding			ovary(3)|breast(1)|kidney(1)	5						CTTCTGATGTGATGCATGCTG	0.418			NA											19	74					0	0	0.007413	0	0
PLXNA1	5361	broad.mit.edu	37	3	126737303	126737303	+	Missense_Mutation	SNP	G	G	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr3:126737303G>T	uc003ejg.2	+	19	3762	c.3758G>T	c.(3757-3759)CGC>CTC	p.R1253L		NM_032242	NP_115618	Q9UIW2	PLXA1_HUMAN	plexin A1	1276	Potential.|Cytoplasmic (Potential).				axon guidance	integral to membrane|intracellular|plasma membrane	semaphorin receptor activity			ovary(1)|pancreas(1)|skin(1)	3				GBM - Glioblastoma multiforme(114;0.155)		GATGCTGACCGCACACTCAAG	0.632			NA											9	40					0.000274275	0.000292399	0.004482	1	0
PLXNA1	5361	broad.mit.edu	37	3	126746796	126746796	+	Missense_Mutation	SNP	A	A	G			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr3:126746796A>G	uc003ejg.2	+	23	4311	c.4307A>G	c.(4306-4308)GAG>GGG	p.E1436G	PLXNA1_uc003ejh.2_Missense_Mutation_p.E104G	NM_032242	NP_115618	Q9UIW2	PLXA1_HUMAN	plexin A1	1459	Cytoplasmic (Potential).				axon guidance	integral to membrane|intracellular|plasma membrane	semaphorin receptor activity			ovary(1)|pancreas(1)|skin(1)	3				GBM - Glioblastoma multiforme(114;0.155)		TGCGCTGGGGAGCCGCTGTTC	0.667			NA											6	34					0	0	0.004482	0	0
EEFSEC	60678	broad.mit.edu	37	3	128060645	128060645	+	Silent	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr3:128060645C>T	uc003eki.2	+	5	1394	c.1356C>T	c.(1354-1356)CAC>CAT	p.H452H	EEFSEC_uc003ekj.2_Silent_p.H397H	NM_021937	NP_068756	P57772	SELB_HUMAN	eukaryotic elongation factor,	452						cytoplasm|nucleus	GTP binding|GTPase activity|translation elongation factor activity			ovary(1)	1						TCCTGCTCCACGGGCTAGAGG	0.612			NA											25	43					0	0	0.00333	0	0
PLXND1	23129	broad.mit.edu	37	3	129290609	129290610	+	Missense_Mutation	DNP	CT	CT	AC			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	CT	CT	-	-	CT	CT	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr3:129290609_129290610CT>AC	uc003emx.2	-	16	3255_3256	c.3155_3156AG>GT	c.(3154-3156)GAG>GGT	p.E1052G		NM_015103	NP_055918	Q9Y4D7	PLXD1_HUMAN	plexin D1 precursor	1052	Extracellular (Potential).|IPT/TIG 2.				axon guidance	integral to membrane|intracellular|plasma membrane				large_intestine(1)	1						AGCCCCGACGCTCGAAGCGCAC	0.663	Ovarian(97;366 1484 3738 22084 39045)		NA											6	44					0	0	0.004672	0	0
EPHB1	2047	broad.mit.edu	37	3	134670262	134670262	+	Missense_Mutation	SNP	A	A	G			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr3:134670262A>G	uc003eqt.2	+	3	393	c.173A>G	c.(172-174)TAC>TGC	p.Y58C	EPHB1_uc010htz.1_RNA|EPHB1_uc011bly.1_Missense_Mutation_p.Y58C	NM_004441	NP_004432	P54762	EPHB1_HUMAN	ephrin receptor EphB1 precursor	58	Extracellular (Potential).					integral to plasma membrane	ATP binding|ephrin receptor activity|protein binding			lung(11)|ovary(6)|stomach(4)|breast(3)|central_nervous_system(2)|skin(2)|large_intestine(1)|pancreas(1)	30						ATCCGCACCTACCAGGTGTGC	0.527			NA											2	10					0	0	0.004672	0	0
EPHB1	2047	broad.mit.edu	37	3	134851748	134851748	+	Missense_Mutation	SNP	G	G	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr3:134851748G>T	uc003eqt.2	+	5	1374	c.1154G>T	c.(1153-1155)GGC>GTC	p.G385V	EPHB1_uc010htz.1_RNA|EPHB1_uc011bly.1_3'UTR|EPHB1_uc003equ.2_5'UTR	NM_004441	NP_004432	P54762	EPHB1_HUMAN	ephrin receptor EphB1 precursor	385	Extracellular (Potential).|Fibronectin type-III 1.					integral to plasma membrane	ATP binding|ephrin receptor activity|protein binding			lung(11)|ovary(6)|stomach(4)|breast(3)|central_nervous_system(2)|skin(2)|large_intestine(1)|pancreas(1)	30						AGGCAGCTGGGCCTGACGGAG	0.597			NA											3	39					0.004672	0.004818	0.004672	1	0
PLS1	5357	broad.mit.edu	37	3	142388273	142388273	+	Missense_Mutation	SNP	G	G	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr3:142388273G>T	uc010huv.2	+	3	271	c.112G>T	c.(112-114)GAC>TAC	p.D38Y	PLS1_uc003euz.2_Missense_Mutation_p.D38Y|PLS1_uc003eva.2_Missense_Mutation_p.D38Y	NM_001145319	NP_001138791	Q14651	PLSI_HUMAN	plastin 1	38	EF-hand 1.					cytoplasm	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(1)	1						TGAACTTCAAGACCTGTTTAA	0.368			NA											8	43					5.18039e-06	5.81293e-06	0.00308	1	0
MED12L	116931	broad.mit.edu	37	3	150881826	150881826	+	Missense_Mutation	SNP	G	G	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr3:150881826G>T	uc003eyp.2	+	8	1292	c.1254G>T	c.(1252-1254)CAG>CAT	p.Q418H	MED12L_uc011bnz.1_Intron|MED12L_uc003eyn.2_Missense_Mutation_p.Q418H|MED12L_uc003eyo.2_Missense_Mutation_p.Q418H	NM_053002	NP_443728	Q86YW9	MD12L_HUMAN	mediator of RNA polymerase II transcription,	418					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	mediator complex				ovary(4)|large_intestine(1)|central_nervous_system(1)|skin(1)	7			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			CTTTCAATCAGCAGGTAGACT	0.378			NA											6	110					0.00116845	0.00122497	0.001168	1	0
MED12L	116931	broad.mit.edu	37	3	150906262	150906262	+	Missense_Mutation	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr3:150906262C>T	uc003eyp.2	+	12	1786	c.1748C>T	c.(1747-1749)TCT>TTT	p.S583F	MED12L_uc011bnz.1_Missense_Mutation_p.S443F|MED12L_uc003eyn.2_Missense_Mutation_p.S583F|MED12L_uc003eyo.2_Missense_Mutation_p.S583F	NM_053002	NP_443728	Q86YW9	MD12L_HUMAN	mediator of RNA polymerase II transcription,	583					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	mediator complex				ovary(4)|large_intestine(1)|central_nervous_system(1)|skin(1)	7			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			CAGGCCCCCTCTTTGTGTAAG	0.333			NA											13	93					0	0	0.004007	0	0
PLCH1	23007	broad.mit.edu	37	3	155215184	155215184	+	Missense_Mutation	SNP	T	T	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr3:155215184T>A	uc011bok.1	-	14	2060	c.1783A>T	c.(1783-1785)ATG>TTG	p.M595L	PLCH1_uc011boj.1_Missense_Mutation_p.M595L|PLCH1_uc011bol.1_Missense_Mutation_p.M577L	NM_001130960	NP_001124432	Q4KWH8	PLCH1_HUMAN	phospholipase C eta 1 isoform a	595					lipid catabolic process|phosphatidylinositol-mediated signaling	membrane	calcium ion binding|calcium-dependent phospholipase C activity|phosphatidylinositol phospholipase C activity|signal transducer activity			skin(3)|ovary(1)	4			Lung(72;0.11)|LUSC - Lung squamous cell carcinoma(72;0.114)			CAGAGCTTCATGGTTTTCCTT	0.473			NA											16	53					0	0	0.004007	0	0
SLC33A1	9197	broad.mit.edu	37	3	155571195	155571195	+	Missense_Mutation	SNP	C	C	G			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr3:155571195C>G	uc003fan.3	-	1	973	c.592G>C	c.(592-594)GAT>CAT	p.D198H	SLC33A1_uc003fao.1_Missense_Mutation_p.D198H	NM_004733	NP_004724	O00400	ACATN_HUMAN	acetyl-coenzyme A transporter	198	Cytoplasmic (Potential).				cell death|transmembrane transport	endoplasmic reticulum membrane|Golgi membrane|integral to plasma membrane|membrane fraction	acetyl-CoA transporter activity			ovary(2)|large_intestine(1)|pancreas(1)	4			Lung(72;0.11)|LUSC - Lung squamous cell carcinoma(72;0.114)			GCCCAACCATCGACGGCAATG	0.473			NA											11	44					0	0	0.008291	0	0
GMPS	8833	broad.mit.edu	37	3	155615825	155615825	+	Missense_Mutation	SNP	A	A	G			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr3:155615825A>G	uc003faq.2	+	3	654	c.319A>G	c.(319-321)ATG>GTG	p.M107V	GMPS_uc011bom.1_Intron	NM_003875	NP_003866	P49915	GUAA_HUMAN	guanine monophosphate synthetase	107	Glutamine amidotransferase type-1.				glutamine metabolic process|purine base biosynthetic process	cytosol	ATP binding|GMP synthase (glutamine-hydrolyzing) activity|GMP synthase activity			ovary(2)|lung(1)	3			Lung(72;0.11)|LUSC - Lung squamous cell carcinoma(72;0.114)		L-Glutamic Acid(DB00142)|L-Glutamine(DB00130)	TTGCTATGGTATGCAGGTATG	0.363	Ovarian(153;896 1876 4149 15499 28134)		NA	T	MLL	AML								23	99					0	0	0.00278	0	0
SHOX2	6474	broad.mit.edu	37	3	157820536	157820536	+	Silent	SNP	G	G	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr3:157820536G>T	uc003fbr.2	-	2	625	c.486C>A	c.(484-486)ACC>ACA	p.T162T	SHOX2_uc003fbs.2_Silent_p.T186T|SHOX2_uc010hvw.2_Silent_p.T162T	NM_006884	NP_006875	O60902	SHOX2_HUMAN	short stature homeobox 2 isoform a	162	Homeobox.				nervous system development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0			Lung(72;0.00318)|LUSC - Lung squamous cell carcinoma(72;0.0043)			CGGGATAGTGGGTCTCGTCAA	0.597			NA											84	75					2.13026e-44	2.99723e-44	0.01441	1	0
PPM1L	151742	broad.mit.edu	37	3	160474243	160474243	+	Silent	SNP	G	G	C			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr3:160474243G>C	uc003fdr.2	+	1	248	c.147G>C	c.(145-147)GTG>GTC	p.V49V		NM_139245	NP_640338	Q5SGD2	PPM1L_HUMAN	protein phosphatase 1 (formerly 2C)-like	49	Cytoplasmic (Potential).				protein dephosphorylation|sphingolipid metabolic process	endoplasmic reticulum membrane|integral to membrane|protein serine/threonine phosphatase complex	metal ion binding|protein serine/threonine phosphatase activity			breast(1)	1			Lung(72;0.00149)|LUSC - Lung squamous cell carcinoma(72;0.00216)			AGACCATCGTGAAGTCCAGCC	0.562	Pancreas(86;250 1994 13715 43211)		NA											19	111					0	0	0.006122	0	0
LRRC31	79782	broad.mit.edu	37	3	169579498	169579498	+	Missense_Mutation	SNP	C	C	G			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr3:169579498C>G	uc003fgc.1	-	2	356	c.279G>C	c.(277-279)TTG>TTC	p.L93F	LRRC31_uc010hwp.1_Missense_Mutation_p.L93F	NM_024727	NP_079003	Q6UY01	LRC31_HUMAN	leucine rich repeat containing 31	93										ovary(2)|skin(1)	3	all_cancers(22;2.76e-22)|all_epithelial(15;4.73e-27)|all_lung(20;9.24e-17)|Lung NSC(18;3.85e-16)|Ovarian(172;0.000223)|Breast(254;0.197)		Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.00943)			CACAGTTATTCAAATCTAGAC	0.428			NA											35	296					0	0	0.003755	0	0
PLD1	5337	broad.mit.edu	37	3	171395480	171395480	+	Silent	SNP	G	G	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr3:171395480G>A	uc003fhs.2	-	17	1988	c.1872C>T	c.(1870-1872)ACC>ACT	p.T624T	PLD1_uc003fht.2_Silent_p.T586T|PLD1_uc003fhv.1_5'UTR	NM_002662	NP_002653	Q13393	PLD1_HUMAN	phospholipase D1 isoform a	624	Catalytic.				cell communication|chemotaxis|Ras protein signal transduction	endoplasmic reticulum membrane|Golgi membrane|late endosome membrane|perinuclear region of cytoplasm	NAPE-specific phospholipase D activity|phosphatidylinositol binding|phospholipase D activity			ovary(2)|lung(1)	3	all_cancers(22;4.53e-19)|Ovarian(172;0.00197)|Breast(254;0.186)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)		Choline(DB00122)	GGATGGACCCGGTATCTGTGA	0.488	NSCLC(149;2174 3517 34058)		NA											7	65					0	0	0.001984	0	0
NLGN1	22871	broad.mit.edu	37	3	173998896	173998896	+	Missense_Mutation	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr3:173998896C>T	uc003fio.1	+	7	2698	c.2275C>T	c.(2275-2277)CCC>TCC	p.P759S	NLGN1_uc003fip.1_Missense_Mutation_p.P759S	NM_014932	NP_055747	Q8N2Q7	NLGN1_HUMAN	neuroligin 1	776	Cytoplasmic (Potential).				calcium-dependent cell-cell adhesion|neuron cell-cell adhesion|neuronal signal transduction|positive regulation of dendritic spine development|positive regulation of excitatory postsynaptic membrane potential|positive regulation of intracellular protein kinase cascade|positive regulation of synaptogenesis|protein targeting|regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|regulation of N-methyl-D-aspartate selective glutamate receptor activity|synapse assembly|synaptic vesicle targeting	cell junction|cell surface|dendrite|integral to plasma membrane|postsynaptic density|postsynaptic membrane	cell adhesion molecule binding|neurexin binding|receptor activity			lung(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)|ovary(1)|pancreas(1)	7	Ovarian(172;0.0025)		LUSC - Lung squamous cell carcinoma(14;5.36e-13)|Lung(28;9.49e-13)			GACCGCCTGTCCCCCAGATTA	0.458			NA											27	34					0	0	0.005443	0	0
TBL1XR1	79718	broad.mit.edu	37	3	176769466	176769466	+	Missense_Mutation	SNP	C	C	G			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr3:176769466C>G	uc003fiw.3	-	5	513	c.253G>C	c.(253-255)GAT>CAT	p.D85H	TBL1XR1_uc003fix.3_Missense_Mutation_p.D85H|TBL1XR1_uc011bpz.1_5'UTR|TBL1XR1_uc003fiy.2_Missense_Mutation_p.D85H	NM_024665	NP_078941	Q9BZK7	TBL1R_HUMAN	transducin (beta)-like 1 X-linked receptor 1	85	F-box-like.				canonical Wnt receptor signaling pathway|cellular lipid metabolic process|chromatin modification|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|proteasomal ubiquitin-dependent protein catabolic process|transcription, DNA-dependent	spindle microtubule|transcriptional repressor complex	beta-catenin binding|histone binding|protein N-terminus binding|transcription corepressor activity|transcription regulatory region DNA binding			ovary(1)	1	all_cancers(143;1.44e-17)|Ovarian(172;0.00163)|Breast(254;0.214)	Acute lymphoblastic leukemia(1;0.00599)|all_hematologic(1;0.0632)|Prostate(884;0.215)	OV - Ovarian serous cystadenocarcinoma(80;9.83e-31)			ATTACGGCATCTATCAGGGAC	0.443			NA											8	50					0	0	0.00308	0	0
EIF4G1	1981	broad.mit.edu	37	3	184039092	184039092	+	Silent	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr3:184039092C>T	uc003fnp.2	+	10	918	c.720C>T	c.(718-720)ATC>ATT	p.I240I	EIF4G1_uc003fno.1_Silent_p.I181I|EIF4G1_uc010hxw.1_Silent_p.I76I|EIF4G1_uc003fnt.2_5'UTR|EIF4G1_uc003fnq.2_Silent_p.I153I|EIF4G1_uc003fnr.2_Silent_p.I76I|EIF4G1_uc010hxx.2_Silent_p.I247I|EIF4G1_uc003fns.2_Silent_p.I200I|EIF4G1_uc010hxy.2_Silent_p.I247I|EIF4G1_uc003fnv.3_Silent_p.I240I|EIF4G1_uc003fnu.3_Silent_p.I240I|EIF4G1_uc003fnw.2_Silent_p.I247I|EIF4G1_uc003fnx.2_Silent_p.I44I|EIF4G1_uc003fny.3_Silent_p.I44I	NM_198241	NP_937884	Q04637	IF4G1_HUMAN	eukaryotic translation initiation factor 4	240					insulin receptor signaling pathway|interspecies interaction between organisms|nuclear-transcribed mRNA poly(A) tail shortening|regulation of translational initiation	cytosol|eukaryotic translation initiation factor 4F complex	protein binding|translation initiation factor activity			lung(2)|ovary(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	7	all_cancers(143;1.06e-10)|Ovarian(172;0.0339)		Epithelial(37;1.53e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			AGGGAGCAATCATTGCTGACC	0.572			NA											25	168					0	0	0.004656	0	0
EIF4G1	1981	broad.mit.edu	37	3	184044714	184044714	+	Nonsense_Mutation	SNP	C	C	G			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr3:184044714C>G	uc003fnp.2	+	23	3569	c.3371C>G	c.(3370-3372)TCA>TGA	p.S1124*	EIF4G1_uc003fnt.2_Nonsense_Mutation_p.S835*|EIF4G1_uc003fnq.2_Nonsense_Mutation_p.S1037*|EIF4G1_uc003fnr.2_Nonsense_Mutation_p.S960*|EIF4G1_uc010hxx.2_Nonsense_Mutation_p.S1131*|EIF4G1_uc003fns.2_Nonsense_Mutation_p.S1084*|EIF4G1_uc010hxy.2_Nonsense_Mutation_p.S1131*|EIF4G1_uc003fnv.3_Nonsense_Mutation_p.S1125*|EIF4G1_uc003fnu.3_Nonsense_Mutation_p.S1124*|EIF4G1_uc003fnw.2_Nonsense_Mutation_p.S1131*|EIF4G1_uc003fnx.2_Nonsense_Mutation_p.S929*|EIF4G1_uc003fny.3_Nonsense_Mutation_p.S928*|EIF4G1_uc003foa.2_5'Flank	NM_198241	NP_937884	Q04637	IF4G1_HUMAN	eukaryotic translation initiation factor 4	1124					insulin receptor signaling pathway|interspecies interaction between organisms|nuclear-transcribed mRNA poly(A) tail shortening|regulation of translational initiation	cytosol|eukaryotic translation initiation factor 4F complex	protein binding|translation initiation factor activity			lung(2)|ovary(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	7	all_cancers(143;1.06e-10)|Ovarian(172;0.0339)		Epithelial(37;1.53e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			AATCGCTTCTCAGCCCTTCAA	0.463			NA											9	184					0	0	0.006214	0	0
CHRD	8646	broad.mit.edu	37	3	184102332	184102332	+	Missense_Mutation	SNP	G	G	C			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr3:184102332G>C	uc003fov.2	+	13	1694	c.1448G>C	c.(1447-1449)GGT>GCT	p.G483A	CHRD_uc003fow.2_Missense_Mutation_p.G113A|CHRD_uc003fox.2_Missense_Mutation_p.G483A|CHRD_uc003foy.2_Missense_Mutation_p.G113A|CHRD_uc010hyc.2_Missense_Mutation_p.G73A|CHRD_uc011brr.1_Missense_Mutation_p.G113A	NM_003741	NP_003732	Q9H2X0	CHRD_HUMAN	chordin precursor	483	CHRD 3.				BMP signaling pathway involved in spinal cord dorsal/ventral patterning|floor plate development|negative regulation of BMP signaling pathway|negative regulation of cell migration|positive regulation of cell adhesion|skeletal system development	extracellular space	cytokine binding			skin(2)|ovary(1)	3	all_cancers(143;6.33e-11)|Ovarian(172;0.0339)		Epithelial(37;4.96e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			CAGGCCGTGGGTATCTGCCCT	0.607			NA											198	176					0	0	0.01441	0	0
C3orf70	285382	broad.mit.edu	37	3	184801039	184801039	+	Nonsense_Mutation	SNP	G	G	C			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr3:184801039G>C	uc003fpd.2	-	2	700	c.509C>G	c.(508-510)TCA>TGA	p.S170*		NM_001025266	NP_001020437	A6NLC5	CC070_HUMAN	hypothetical protein LOC285382	170											0						GCTCTCTTTTGAAATTAAGGC	0.463			NA											24	60					0	0	0.003954	0	0
RTP4	64108	broad.mit.edu	37	3	187088747	187088747	+	Silent	SNP	T	T	C			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr3:187088747T>C	uc003frm.2	+	2	389	c.327T>C	c.(325-327)GAT>GAC	p.D109D		NM_022147	NP_071430	Q96DX8	RTP4_HUMAN	28kD interferon responsive protein	109	Cytoplasmic (Potential).				detection of chemical stimulus involved in sensory perception of bitter taste|protein targeting to membrane	cytoplasm|integral to membrane	protein binding				0	all_cancers(143;4.66e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;5.56e-18)	GBM - Glioblastoma multiforme(93;0.0269)		TCTCCTCGGATAGCACCATGA	0.507			NA											7	30					0	0	0.001984	0	0
BCL6	604	broad.mit.edu	37	3	187447552	187447552	+	Missense_Mutation	SNP	C	C	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr3:187447552C>A	uc003frp.3	-	5	1098	c.641G>T	c.(640-642)CGG>CTG	p.R214L	BCL6_uc011bsf.1_Missense_Mutation_p.R214L|BCL6_uc010hza.2_Missense_Mutation_p.R112L|BCL6_uc003frq.1_Missense_Mutation_p.R214L	NM_001130845	NP_001124317	P41182	BCL6_HUMAN	B-cell lymphoma 6 protein isoform 1	214					negative regulation of B cell apoptosis|negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|negative regulation of transcription from RNA polymerase II promoter|positive regulation of apoptosis|protein import into nucleus, translocation|regulation of germinal center formation|response to DNA damage stimulus	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)|lung(2)|central_nervous_system(1)	5	all_cancers(143;9.45e-12)|Ovarian(172;0.0418)		OV - Ovarian serous cystadenocarcinoma(80;1.76e-18)	GBM - Glioblastoma multiforme(93;0.0141)		CCGGACATCCCGAAACTCCTC	0.622			NA	T|Mis	IG loci|ZNFN1A1|LCP1|PIM1|TFRC|MHC2TA|NACA|HSPCB|HSPCA|HIST1H4I|IL21R| POU2AF1|ARHH|EIF4A2|SFRS3	NHL|CLL								14	66					3.27435e-08	3.89702e-08	0.00245	1	0
C3orf59	151963	broad.mit.edu	37	3	192516994	192516994	+	Silent	SNP	G	G	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr3:192516994G>A	uc011bsp.1	-	2	978	c.657C>T	c.(655-657)ATC>ATT	p.I219I		NM_178496	NP_848591	Q8IYB1	M21D2_HUMAN	hypothetical protein LOC151963	219											0	all_cancers(143;1.56e-08)|Ovarian(172;0.0634)		OV - Ovarian serous cystadenocarcinoma(49;2.8e-18)|LUSC - Lung squamous cell carcinoma(58;8.04e-06)|Lung(62;8.62e-06)	GBM - Glioblastoma multiforme(46;3.86e-05)		TGATGGAGATGATGGTCCCAT	0.468			NA											8	96					0	0	0.00308	0	0
OPA1	4976	broad.mit.edu	37	3	193364866	193364866	+	Silent	SNP	A	A	G			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr3:193364866A>G	uc003ftm.2	+	17	1836	c.1602A>G	c.(1600-1602)CTA>CTG	p.L534L	OPA1_uc003ftg.2_Silent_p.L589L|OPA1_uc003fth.2_Silent_p.L553L|OPA1_uc003fti.2_Silent_p.L571L|OPA1_uc003ftj.2_Silent_p.L552L|OPA1_uc003ftk.2_Silent_p.L535L|OPA1_uc003ftl.2_Silent_p.L516L|OPA1_uc003ftn.2_Silent_p.L498L	NM_015560	NP_056375	O60313	OPA1_HUMAN	optic atrophy 1 isoform 1	534	Mitochondrial intermembrane (By similarity).				apoptosis|axon transport of mitochondrion|inner mitochondrial membrane organization|mitochondrial fission|mitochondrial fusion|positive regulation of anti-apoptosis|response to stimulus|visual perception	dendrite|integral to membrane|mitochondrial crista|mitochondrial intermembrane space|mitochondrial outer membrane	GTP binding|GTPase activity|magnesium ion binding|protein binding				0	all_cancers(143;9.56e-09)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(49;9.19e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;0.000162)		CAAGCATGCTAAAGGCACACC	0.368			NA											21	13					0	0	0.014323	0	0
LRRC15	131578	broad.mit.edu	37	3	194080147	194080147	+	Silent	SNP	G	G	T	rs113394891	byFrequency	TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr3:194080147G>T	uc003ftu.2	-	2	1712	c.1626C>A	c.(1624-1626)GCC>GCA	p.A542A	LRRC15_uc003ftt.2_Silent_p.A548A	NM_130830	NP_570843	Q8TF66	LRC15_HUMAN	leucine rich repeat containing 15 isoform b	542	Helical; (Potential).					integral to membrane				ovary(3)	3	all_cancers(143;5.31e-09)|Ovarian(172;0.0634)		OV - Ovarian serous cystadenocarcinoma(49;2.2e-17)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;4.94e-05)		TTACAATGGCGGCAATGGCCA	0.597			NA											105	72					3.01496e-42	4.23787e-42	0.01441	1	0
PIGZ	80235	broad.mit.edu	37	3	196675122	196675122	+	Missense_Mutation	SNP	G	G	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr3:196675122G>A	uc003fxh.2	-	3	793	c.646C>T	c.(646-648)CTT>TTT	p.L216F		NM_025163	NP_079439	Q86VD9	PIGZ_HUMAN	phosphatidylinositol glycan anchor biosynthesis,	216	Helical; (Potential).				GPI anchor biosynthetic process	integral to membrane|intrinsic to endoplasmic reticulum membrane	alpha-1,2-mannosyltransferase activity			ovary(3)	3	all_cancers(143;1.05e-08)|Ovarian(172;0.0634)|Breast(254;0.0838)		Epithelial(36;4.29e-24)|all cancers(36;2.79e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.03e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00603)		ATGCCTCCAAGAAGCCAGCTG	0.637			NA											18	129					0	0	0.007413	0	0
ZNF718	255403	broad.mit.edu	37	4	53308	53308	+	Splice_Site	SNP	G	G	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr4:53308G>T	uc003fzt.3	+	3	64	c.-69_splice	c.e3+1		ZNF595_uc003fzu.1_RNA|ZNF595_uc010iay.1_RNA|ZNF595_uc003fzv.1_5'UTR|ZNF595_uc011bus.1_5'UTR|ZNF595_uc011but.1_5'UTR	NM_001039127	NP_001034216	Q3SXZ3	ZN718_HUMAN	zinc finger protein 718						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_cancers(4;0.0738)|all_epithelial(65;0.139)		Lung(54;0.0681)|Epithelial(2;0.0838)|all cancers(2;0.135)|LUSC - Lung squamous cell carcinoma(95;0.18)		CACAGCCTCTGCCTCCCGTTG	0.607			NA											10	127					1.58986e-06	1.81627e-06	0.008291	1	0
SPON2	10417	broad.mit.edu	37	4	1165838	1165838	+	Missense_Mutation	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr4:1165838C>T	uc003gcn.3	-	1	49	c.22G>A	c.(22-24)GCC>ACC	p.A8T	SPON2_uc003gco.3_Missense_Mutation_p.A8T|SPON2_uc010ibr.2_Missense_Mutation_p.A8T|SPON2_uc003gcm.1_5'Flank	NM_012445	NP_036577	Q9BUD6	SPON2_HUMAN	spondin 2, extracellular matrix protein	8					axon guidance|cell adhesion|innate immune response	proteinaceous extracellular matrix	metal ion binding			central_nervous_system(1)	1			OV - Ovarian serous cystadenocarcinoma(23;0.00805)	UCEC - Uterine corpus endometrioid carcinoma (64;0.139)|Colorectal(103;0.19)		CCCAGGGCGGCGGCCGGGCTG	0.726			NA											7	27					0	0	0.00308	0	0
NOP14	8602	broad.mit.edu	37	4	2948195	2948195	+	Missense_Mutation	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr4:2948195C>T	uc003ggj.1	-	11	1651	c.1579G>A	c.(1579-1581)GAG>AAG	p.E527K	C4orf10_uc003gge.1_Intron|C4orf10_uc003ggh.2_Intron|C4orf10_uc003ggi.1_Intron|NOP14_uc010icp.2_Missense_Mutation_p.E273K|NOP14_uc003ggk.3_Missense_Mutation_p.E527K|NOP14_uc003ggl.2_Missense_Mutation_p.E527K	NM_003703	NP_003694	P78316	NOP14_HUMAN	probable nucleolar complex protein 14	527					endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	mitochondrion|Noc4p-Nop14p complex|small-subunit processome	snoRNA binding			pancreas(1)	1						TCTTCCATCTCATGCATCGCA	0.473			NA											6	71					0	0	0.00308	0	0
RGS12	6002	broad.mit.edu	37	4	3424297	3424297	+	Missense_Mutation	SNP	G	G	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr4:3424297G>T	uc003ggw.2	+	11	3937	c.3033G>T	c.(3031-3033)AAG>AAT	p.K1011N	RGS12_uc003ggv.2_Missense_Mutation_p.K1011N|RGS12_uc003ggy.1_Missense_Mutation_p.K409N|RGS12_uc003ggz.2_Missense_Mutation_p.K363N|RGS12_uc010icu.1_Missense_Mutation_p.K210N|RGS12_uc011bvs.1_Missense_Mutation_p.K353N|RGS12_uc003gha.2_Missense_Mutation_p.K353N|RGS12_uc010icv.2_Missense_Mutation_p.K210N|RGS12_uc003ghb.2_Missense_Mutation_p.K210N	NM_198229	NP_937872	O14924	RGS12_HUMAN	regulator of G-protein signalling 12 isoform 1	1011	RBD 1.					condensed nuclear chromosome|cytoplasm|plasma membrane	GTPase activator activity|receptor signaling protein activity			skin(1)	1				UCEC - Uterine corpus endometrioid carcinoma (64;0.168)		GCGGGGACAAGGTACTGGGCC	0.677			NA											20	16					2.37509e-13	3.0465e-13	0.010504	1	0
OTOP1	133060	broad.mit.edu	37	4	4199621	4199621	+	Missense_Mutation	SNP	C	C	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr4:4199621C>A	uc003ghp.1	-	5	970	c.940G>T	c.(940-942)GGC>TGC	p.G314C		NM_177998	NP_819056	Q7RTM1	OTOP1_HUMAN	otopetrin 1	314	Helical; (Potential).				biomineral tissue development	extracellular space|integral to membrane				ovary(2)|central_nervous_system(1)	3				UCEC - Uterine corpus endometrioid carcinoma (64;0.168)		AGGACTGCGCCCACCATGACC	0.577			NA											26	36					3.28513e-13	4.20265e-13	0.003954	1	0
TADA2B	93624	broad.mit.edu	37	4	7056721	7056721	+	Silent	SNP	A	A	C			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr4:7056721A>C	uc003gjw.3	+	2	1354	c.1203A>C	c.(1201-1203)CTA>CTC	p.L401L	TADA2B_uc010idi.2_Silent_p.L326L	NM_152293	NP_689506	Q86TJ2	TAD2B_HUMAN	transcriptional adaptor 2 (ADA2 homolog,	401					regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|zinc ion binding				0						ACAAAGTCCTAAAGAAAAGGA	0.488			NA											11	32					0	0	0.008291	0	0
ACOX3	8310	broad.mit.edu	37	4	8418229	8418229	+	Missense_Mutation	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr4:8418229C>T	uc010idk.2	-	2	165	c.20G>A	c.(19-21)GGA>GAA	p.G7E	ACOX3_uc003glc.3_Missense_Mutation_p.G7E|ACOX3_uc003gld.3_Missense_Mutation_p.G7E|ACOX3_uc003gle.1_5'Flank	NM_003501	NP_003492	O15254	ACOX3_HUMAN	acyl-Coenzyme A oxidase 3 isoform a	7					bile acid metabolic process|fatty acid beta-oxidation using acyl-CoA oxidase	peroxisomal matrix	acyl-CoA dehydrogenase activity|flavin adenine dinucleotide binding|pristanoyl-CoA oxidase activity			central_nervous_system(1)	1						TGTGTCGCCTCCTTCCACAGT	0.572			NA											4	39					0	0	0.009096	0	0
DRD5	1816	broad.mit.edu	37	4	9784051	9784051	+	Missense_Mutation	SNP	T	T	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr4:9784051T>A	uc003gmb.3	+	1	794	c.398T>A	c.(397-399)GTC>GAC	p.V133D		NM_000798	NP_000789	P21918	DRD5_HUMAN	dopamine receptor D5	133	Helical; Name=3; (Potential).				activation of adenylate cyclase activity by dopamine receptor signaling pathway|activation of phospholipase C activity by dopamine receptor signaling pathway|cellular calcium ion homeostasis|negative regulation of NAD(P)H oxidase activity|reactive oxygen species metabolic process|synaptic transmission, dopaminergic	integral to plasma membrane				skin(1)	1					Apomorphine(DB00714)|Carphenazine(DB01038)|Fenoldopam(DB00800)|Zuclopenthixol(DB01624)	AACCTGTGCGTCATCAGCGTG	0.627			NA											16	28					0	0	0.004007	0	0
KLB	152831	broad.mit.edu	37	4	39448475	39448475	+	Missense_Mutation	SNP	G	G	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr4:39448475G>A	uc003gua.2	+	4	2226	c.2129G>A	c.(2128-2130)GGG>GAG	p.G710E	KLB_uc011byj.1_Missense_Mutation_p.G701E	NM_175737	NP_783864	Q86Z14	KLOTB_HUMAN	klotho beta	710	Extracellular (Potential).|Glycosyl hydrolase-1 2.				carbohydrate metabolic process	integral to membrane|plasma membrane	cation binding|fibroblast growth factor binding|hydrolase activity, hydrolyzing O-glycosyl compounds			skin(1)	1						GACACCTACGGGGCGGCGCAC	0.657			NA											19	47					0	0	0.008871	0	0
N4BP2	55728	broad.mit.edu	37	4	40099000	40099000	+	Missense_Mutation	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr4:40099000C>T	uc003guy.3	+	3	378	c.40C>T	c.(40-42)CGG>TGG	p.R14W	N4BP2_uc010ifq.2_5'UTR	NM_018177	NP_060647	Q86UW6	N4BP2_HUMAN	Nedd4 binding protein 2	14						cytoplasm	ATP binding|ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity|endonuclease activity|protein binding			lung(3)|breast(2)|kidney(2)|ovary(1)	8						AAATCCTTTTCGGAAGACTGC	0.413			NA											13	27					0	0	0.004007	0	0
RBM47	54502	broad.mit.edu	37	4	40440598	40440598	+	Missense_Mutation	SNP	C	C	G			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr4:40440598C>G	uc003gvc.2	-	4	1023	c.313G>C	c.(313-315)GAC>CAC	p.D105H	RBM47_uc003gvd.2_Missense_Mutation_p.D105H|RBM47_uc003gve.2_RNA|RBM47_uc011bys.1_Missense_Mutation_p.D67H|RBM47_uc003gvg.1_Missense_Mutation_p.D105H	NM_001098634	NP_001092104	A0AV96	RBM47_HUMAN	RNA binding motif protein 47 isoform a	105	RRM 1.					nucleus	nucleotide binding|RNA binding			breast(3)	3						CCGTCAAAGTCCATCATGAGG	0.632			NA											13	70					0	0	0.003163	0	0
SLC30A9	10463	broad.mit.edu	37	4	42024921	42024921	+	Silent	SNP	A	A	G			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr4:42024921A>G	uc003gwl.2	+	5	647	c.501A>G	c.(499-501)GTA>GTG	p.V167V	SLC30A9_uc011byx.1_5'UTR	NM_006345	NP_006336	Q6PML9	ZNT9_HUMAN	solute carrier family 30 (zinc transporter),	167					nucleotide-excision repair|zinc ion transport	cytoskeleton|integral to membrane|nucleus	cation transmembrane transporter activity|nucleotide binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(2)|ovary(1)	3						CTTTTACTGTATACTTGAGAT	0.323			NA											4	21					0	0	0.000602	0	0
LRRC66	339977	broad.mit.edu	37	4	52869406	52869406	+	Missense_Mutation	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr4:52869406C>T	uc003gzi.2	-	2	662	c.649G>A	c.(649-651)GAC>AAC	p.D217N		NM_001024611	NP_001019782	Q68CR7	LRC66_HUMAN	leucine rich repeat containing 66	217	LRR 5.					integral to membrane				ovary(1)|central_nervous_system(1)|skin(1)	3						TTTTTGAGGTCCTTGAAGGCT	0.343			NA											17	19					0	0	0.004007	0	0
PPAT	5471	broad.mit.edu	37	4	57261580	57261580	+	Missense_Mutation	SNP	C	C	G			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr4:57261580C>G	uc003hbr.2	-	11	1694	c.1492G>C	c.(1492-1494)GAA>CAA	p.E498Q		NM_002703	NP_002694	Q06203	PUR1_HUMAN	phosphoribosyl pyrophosphate amidotransferase	498					glutamine metabolic process|nucleoside metabolic process|purine base biosynthetic process|purine ribonucleoside monophosphate biosynthetic process	cytosol	4 iron, 4 sulfur cluster binding|amidophosphoribosyltransferase activity|metal ion binding				0	Glioma(25;0.08)|all_neural(26;0.101)				L-Glutamine(DB00130)|Thioguanine(DB00352)	CCACTCTTTTCAAAACATTCC	0.358			NA											3	12					0	0	0.004672	0	0
EPHA5	2044	broad.mit.edu	37	4	66467425	66467425	+	Missense_Mutation	SNP	A	A	G			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr4:66467425A>G	uc003hcy.2	-	3	1037	c.844T>C	c.(844-846)TGG>CGG	p.W282R	EPHA5_uc003hcx.2_Missense_Mutation_p.W213R|EPHA5_uc003hcz.2_Missense_Mutation_p.W282R|EPHA5_uc011cah.1_Missense_Mutation_p.W282R|EPHA5_uc011cai.1_Missense_Mutation_p.W282R|EPHA5_uc003hda.2_Missense_Mutation_p.W282R	NM_004439	NP_004430	P54756	EPHA5_HUMAN	ephrin receptor EphA5 isoform a precursor	282	Extracellular (Potential).|Cys-rich.				cAMP-mediated signaling|neuron development	dendrite|external side of plasma membrane|integral to plasma membrane|neuronal cell body|perinuclear region of cytoplasm|rough endoplasmic reticulum	ATP binding|transmembrane-ephrin receptor activity			lung(19)|stomach(2)|ovary(2)|central_nervous_system(1)	24						GGCACCAGCCACTCCCCTTCG	0.532			NA								TSP Lung(17;0.13)			13	20					0	0	0.00245	0	0
UGT2B11	10720	broad.mit.edu	37	4	70070363	70070363	+	Silent	SNP	A	A	G			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr4:70070363A>G	uc003heh.2	-	5	1104	c.1095T>C	c.(1093-1095)CAT>CAC	p.H365H	uc003hei.1_Intron	NM_001073	NP_001064	O75310	UDB11_HUMAN	UDP glucuronosyltransferase 2 family,	365					estrogen metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			ovary(1)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	3						TGGTTTTTGGATGACCTAGGA	0.378			NA											7	31					0	0	0.001984	0	0
ANKRD17	26057	broad.mit.edu	37	4	73962875	73962875	+	Silent	SNP	A	A	C			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr4:73962875A>C	uc003hgp.2	-	27	5253	c.5136T>G	c.(5134-5136)CGT>CGG	p.R1712R	ANKRD17_uc003hgo.2_Silent_p.R1599R|ANKRD17_uc003hgq.2_Silent_p.R1461R|ANKRD17_uc003hgr.2_Silent_p.R1711R	NM_032217	NP_115593	O75179	ANR17_HUMAN	ankyrin repeat domain protein 17 isoform a	1712					interspecies interaction between organisms	cytoplasm|nucleus	RNA binding			ovary(5)|skin(3)|upper_aerodigestive_tract(1)|lung(1)	10	Breast(15;0.000295)		Epithelial(6;8.86e-07)|OV - Ovarian serous cystadenocarcinoma(6;6.22e-06)|all cancers(17;1.51e-05)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			TCTTTTGCCCACGCTTAGGAC	0.388			NA											50	66					0	0	0.01441	0	0
HELQ	113510	broad.mit.edu	37	4	84339310	84339310	+	Missense_Mutation	SNP	T	T	C			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr4:84339310T>C	uc003hom.2	-	16	3178	c.2999A>G	c.(2998-3000)AAG>AGG	p.K1000R	HELQ_uc010ikb.2_Missense_Mutation_p.K933R|HELQ_uc003hol.3_RNA|HELQ_uc010ikc.2_RNA	NM_133636	NP_598375	Q8TDG4	HELQ_HUMAN	DNA helicase HEL308	1000							ATP binding|ATP-dependent helicase activity|nucleic acid binding			ovary(1)|breast(1)|skin(1)	3						AGTCAGCTTCTTGGTAAGTTC	0.348			NA						Direct_reversal_of_damage|Other_identified_genes_with_known_or_suspected_DNA_repair_function					47	55					0	0	0.01441	0	0
CENPE	1062	broad.mit.edu	37	4	104067129	104067129	+	Missense_Mutation	SNP	G	G	C			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr4:104067129G>C	uc003hxb.1	-	30	4360	c.4270C>G	c.(4270-4272)CTC>GTC	p.L1424V	CENPE_uc003hxc.1_Missense_Mutation_p.L1399V	NM_001813	NP_001804	Q02224	CENPE_HUMAN	centromere protein E	1424	Potential.				blood coagulation|cell division|kinetochore assembly|microtubule-based movement|mitotic chromosome movement towards spindle pole|mitotic metaphase|mitotic metaphase plate congression|mitotic prometaphase|multicellular organismal development|positive regulation of protein kinase activity	condensed chromosome kinetochore|cytosol|microtubule|nucleus|spindle	ATP binding|kinetochore binding|microtubule motor activity			ovary(5)|breast(4)	9				OV - Ovarian serous cystadenocarcinoma(123;2.95e-08)		GACAATCCGAGCATTTCTATT	0.363			NA											6	46					0	0	0.001168	0	0
PAPSS1	9061	broad.mit.edu	37	4	108576016	108576016	+	Silent	SNP	C	C	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr4:108576016C>A	uc003hyk.2	-	8	1020	c.936G>T	c.(934-936)GCG>GCT	p.A312A	PAPSS1_uc011cfh.1_RNA	NM_005443	NP_005434	O43252	PAPS1_HUMAN	3'-phosphoadenosine 5'-phosphosulfate synthase	312	Adenylyl-sulfate kinase.				3'-phosphoadenosine 5'-phosphosulfate biosynthetic process|skeletal system development|sulfate assimilation|xenobiotic metabolic process	cytosol	adenylylsulfate kinase activity|ATP binding|sulfate adenylyltransferase (ATP) activity			ovary(1)	1		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;5.49e-05)		CTTCATGAGTCGCAGTCAGAA	0.458			NA											29	38					4.59853e-10	5.62042e-10	0.005443	1	0
NEUROG2	63973	broad.mit.edu	37	4	113436310	113436310	+	Missense_Mutation	SNP	G	G	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr4:113436310G>T	uc003ias.2	-	2	649	c.322C>A	c.(322-324)CGC>AGC	p.R108S		NM_024019	NP_076924	Q9H2A3	NGN2_HUMAN	neurogenin 2	108					positive regulation of sequence-specific DNA binding transcription factor activity|transcription, DNA-dependent	nucleus	E-box binding			skin(2)|central_nervous_system(1)	3		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.00168)		TTCTTGATGCGCTGCACCGTC	0.687			NA											23	36					1.10513e-12	1.40636e-12	0.014323	1	0
NDST4	64579	broad.mit.edu	37	4	115750957	115750957	+	Missense_Mutation	SNP	T	T	C			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr4:115750957T>C	uc003ibu.2	-	13	3167	c.2488A>G	c.(2488-2490)ATG>GTG	p.M830V	NDST4_uc010imw.2_RNA	NM_022569	NP_072091	Q9H3R1	NDST4_HUMAN	heparan sulfate N-deacetylase/N-sulfotransferase	830	Lumenal (Potential).|Heparan sulfate N-sulfotransferase 4.					Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine N-sulfotransferase activity|hydrolase activity			skin(3)|ovary(1)	4		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.000562)		TCTGGATCCATAGGTGGATAT	0.343			NA											8	8					0	0	0.00308	0	0
NDST4	64579	broad.mit.edu	37	4	115769466	115769466	+	Silent	SNP	A	A	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr4:115769466A>T	uc003ibu.2	-	9	2524	c.1845T>A	c.(1843-1845)CTT>CTA	p.L615L	NDST4_uc010imw.2_RNA	NM_022569	NP_072091	Q9H3R1	NDST4_HUMAN	heparan sulfate N-deacetylase/N-sulfotransferase	615	Lumenal (Potential).|Heparan sulfate N-sulfotransferase 4.					Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine N-sulfotransferase activity|hydrolase activity			skin(3)|ovary(1)	4		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.000562)		AAGGATGCATAAGAAGAAATA	0.318			NA											8	14					0	0	0.00308	0	0
PRDM5	11107	broad.mit.edu	37	4	121738051	121738051	+	Missense_Mutation	SNP	G	G	C			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr4:121738051G>C	uc003idn.2	-	6	929	c.679C>G	c.(679-681)CTA>GTA	p.L227V	PRDM5_uc003ido.2_Intron|PRDM5_uc010ine.2_Intron|PRDM5_uc010inf.2_Intron	NM_018699	NP_061169	Q9NQX1	PRDM5_HUMAN	PR domain containing 5	227					histone deacetylation|histone H3-K9 methylation|mitotic cell cycle|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	repressing transcription factor binding|sequence-specific DNA binding|transcription regulatory region DNA binding|zinc ion binding			central_nervous_system(1)|pancreas(1)	2						GACTCCTTTAGACTGCTTTTC	0.368			NA											15	56					0	0	0.004007	0	0
TNIP3	79931	broad.mit.edu	37	4	122063033	122063033	+	Missense_Mutation	SNP	G	G	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr4:122063033G>T	uc010ing.2	-	9	1019	c.823C>A	c.(823-825)CAC>AAC	p.H275N	TNIP3_uc010inh.2_Missense_Mutation_p.H275N|TNIP3_uc011cgj.1_Missense_Mutation_p.H333N	NM_024873	NP_079149	Q96KP6	TNIP3_HUMAN	TNFAIP3 interacting protein 3	275										ovary(1)	1						TCTTGCAGGTGGAAAACCAAG	0.502			NA											10	16					2.80697e-09	3.40495e-09	0.010729	1	0
SLC25A31	83447	broad.mit.edu	37	4	128651782	128651782	+	Missense_Mutation	SNP	G	G	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr4:128651782G>A	uc003ifl.2	+	1	228	c.82G>A	c.(82-84)GGA>AGA	p.G28R		NM_031291	NP_112581	Q9H0C2	ADT4_HUMAN	solute carrier family 25 (mitochondrial carrier;	28	Solcar 1.|Helical; Name=1; (Potential).				transmembrane transport	cilium|flagellum|integral to membrane|mitochondrial inner membrane	binding|transporter activity				0						TCTGGCCGGCGGAGTCGCGGC	0.602			NA											40	37					0	0	0.009718	0	0
MFSD8	256471	broad.mit.edu	37	4	128843023	128843023	+	Missense_Mutation	SNP	T	T	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr4:128843023T>A	uc003ifp.2	-	11	1257	c.1094A>T	c.(1093-1095)CAG>CTG	p.Q365L	MFSD8_uc011cgu.1_Missense_Mutation_p.Q320L|MFSD8_uc011cgv.1_Intron|MFSD8_uc011cgw.1_RNA	NM_152778	NP_689991	Q8NHS3	MFSD8_HUMAN	major facilitator superfamily domain containing	365	Extracellular (Potential).				cell death|transmembrane transport	integral to membrane|lysosomal membrane				ovary(1)|liver(1)	2						ACCTTCCCACTGTATTTTGGG	0.368			NA											8	13					0	0	0.004482	0	0
PCDH10	57575	broad.mit.edu	37	4	134072994	134072994	+	Missense_Mutation	SNP	C	C	G			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr4:134072994C>G	uc003iha.2	+	1	2525	c.1699C>G	c.(1699-1701)CAA>GAA	p.Q567E	uc003igy.2_5'Flank|PCDH10_uc003igz.2_Missense_Mutation_p.Q567E	NM_032961	NP_116586	Q9P2E7	PCD10_HUMAN	protocadherin 10 isoform 1 precursor	567	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)	2				LUSC - Lung squamous cell carcinoma(193;0.227)		CATAGTGGATCAAAATGACAA	0.637			NA											46	66					0	0	0.010771	0	0
SCOC	60592	broad.mit.edu	37	4	141302217	141302217	+	Missense_Mutation	SNP	A	A	G			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr4:141302217A>G	uc003iif.2	+	4	466	c.439A>G	c.(439-441)AGT>GGT	p.S147G	SCOC_uc003iib.2_Missense_Mutation_p.S110G|SCOC_uc011che.1_Missense_Mutation_p.S110G|SCOC_uc003iid.2_Missense_Mutation_p.S109G|SCOC_uc011chf.1_Missense_Mutation_p.S110G|SCOC_uc011chg.1_Missense_Mutation_p.S82G|SCOC_uc011chh.1_Missense_Mutation_p.S146G|SCOC_uc003iig.2_Missense_Mutation_p.S119G	NM_001153484	NP_001146956	Q9UIL1	SCOC_HUMAN	short coiled-coil protein isoform 1	147						Golgi apparatus|nucleus	protein binding				0	all_hematologic(180;0.162)					GTCAGCTTCTAGTGTTTTTCA	0.338			NA											6	11					0	0	0.001168	0	0
ZNF330	27309	broad.mit.edu	37	4	142143645	142143645	+	Missense_Mutation	SNP	G	G	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr4:142143645G>T	uc003iiq.3	+	2	340	c.120G>T	c.(118-120)ATG>ATT	p.M40I	ZNF330_uc011chl.1_Missense_Mutation_p.W4L	NM_014487	NP_055302	Q9Y3S2	ZN330_HUMAN	zinc finger protein 330	40						chromosome, centromeric region|midbody|nucleolus	protein binding|zinc ion binding				0	all_hematologic(180;0.162)					ATGCCTCAATGGTATCAGCTT	0.363			NA											8	14					7.48243e-07	8.60894e-07	0.006214	1	0
INPP4B	8821	broad.mit.edu	37	4	143181690	143181690	+	Missense_Mutation	SNP	G	G	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr4:143181690G>A	uc003iix.3	-	12	1238	c.643C>T	c.(643-645)CCG>TCG	p.P215S	INPP4B_uc003iiw.3_Missense_Mutation_p.P215S|INPP4B_uc011chm.1_RNA|INPP4B_uc011chn.1_Missense_Mutation_p.P30S|INPP4B_uc011cho.1_RNA|INPP4B_uc011chp.1_Missense_Mutation_p.P86S	NM_003866	NP_003857	O15327	INP4B_HUMAN	inositol polyphosphate-4-phosphatase, type II,	215					signal transduction		phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity|phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity			ovary(1)|lung(1)	2	all_hematologic(180;0.158)					ACACTTTCCGGGGCTGTACAT	0.274			NA											8	15					0	0	0.00308	0	0
PRMT10	90826	broad.mit.edu	37	4	148582162	148582162	+	Silent	SNP	G	G	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr4:148582162G>T	uc003ilc.2	-	7	1123	c.981C>A	c.(979-981)ATC>ATA	p.I327I	PRMT10_uc003ilb.2_5'UTR|PRMT10_uc003ild.2_Silent_p.I214I	NM_138364	NP_612373	Q6P2P2	ANM10_HUMAN	protein arginine methyltransferase 10	327						cytoplasm	binding|protein methyltransferase activity			ovary(1)|central_nervous_system(1)	2						TTGGCAAATGGATACCAGCAA	0.373			NA											6	35					8.12818e-05	8.78788e-05	0.001984	1	0
LRBA	987	broad.mit.edu	37	4	151520208	151520208	+	Silent	SNP	A	A	C			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr4:151520208A>C	uc010ipj.2	-	38	6471	c.5997T>G	c.(5995-5997)CCT>CCG	p.P1999P	LRBA_uc003ilt.3_Silent_p.P658P|LRBA_uc003ilu.3_Silent_p.P1999P	NM_006726	NP_006717	P50851	LRBA_HUMAN	LPS-responsive vesicle trafficking, beach and	1999						endoplasmic reticulum|Golgi apparatus|integral to membrane|lysosome|plasma membrane	protein binding			ovary(3)|breast(3)|skin(1)	7	all_hematologic(180;0.151)					TCGATCCTAGAGGGTTACGCA	0.502			NA											15	47					0	0	0.00245	0	0
NPY2R	4887	broad.mit.edu	37	4	156136166	156136166	+	Missense_Mutation	SNP	G	G	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr4:156136166G>T	uc003ioq.2	+	2	1570	c.1075G>T	c.(1075-1077)GCT>TCT	p.A359S	NPY2R_uc003ior.2_Missense_Mutation_p.A359S	NM_000910	NP_000901	P49146	NPY2R_HUMAN	neuropeptide Y receptor Y2	359	Cytoplasmic (Potential).				cardiac left ventricle morphogenesis|inhibition of adenylate cyclase activity by G-protein signaling pathway|locomotory behavior|outflow tract morphogenesis	integral to plasma membrane	calcium channel regulator activity			lung(2)|skin(1)	3	all_hematologic(180;0.24)	Renal(120;0.0854)				GACATTCAAGGCTAAAAAGAA	0.498			NA											9	28					0.000442599	0.000469777	0.006214	1	0
RAPGEF2	9693	broad.mit.edu	37	4	160259585	160259585	+	Missense_Mutation	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr4:160259585C>T	uc003iqg.3	+	12	2085	c.1775C>T	c.(1774-1776)TCA>TTA	p.S592L		NM_014247	NP_055062	Q9Y4G8	RPGF2_HUMAN	Rap guanine nucleotide exchange factor 2	592					cAMP-mediated signaling|MAPKKK cascade|small GTPase mediated signal transduction	integral to plasma membrane|intracellular	calcium ion binding|diacylglycerol binding|Rap GTPase activator activity|Rap guanyl-nucleotide exchange factor activity|signal transducer activity			lung(2)|upper_aerodigestive_tract(1)|skin(1)	4	all_hematologic(180;0.24)			COAD - Colon adenocarcinoma(41;0.0817)		TTATTGCAGTCACATCATCGC	0.383			NA											12	39					0	0	0.013537	0	0
ANP32C	23520	broad.mit.edu	37	4	165118606	165118606	+	Silent	SNP	G	G	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr4:165118606G>A	uc011cjk.1	-	1	258	c.258C>T	c.(256-258)CTC>CTT	p.L86L	MARCH1_uc003iqs.1_Intron	NM_012403	NP_036535	O43423	AN32C_HUMAN	acidic nuclear phosphoprotein 32C	86	LRR 3.										0	all_hematologic(180;0.203)	Prostate(90;0.0138)|Melanoma(52;0.18)|all_neural(102;0.223)		KIRC - Kidney renal clear cell carcinoma(143;0.242)		ATAGATGCGTGAGGTTTGGAC	0.418			NA											24	64					0	0	0.00333	0	0
ADAM29	11086	broad.mit.edu	37	4	175898412	175898412	+	Missense_Mutation	SNP	T	T	G			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr4:175898412T>G	uc003iuc.2	+	5	2406	c.1736T>G	c.(1735-1737)ATA>AGA	p.I579R	ADAM29_uc003iud.2_Missense_Mutation_p.I579R|ADAM29_uc010irr.2_Missense_Mutation_p.I579R|ADAM29_uc011cki.1_Missense_Mutation_p.I579R	NM_014269	NP_055084	Q9UKF5	ADA29_HUMAN	ADAM metallopeptidase domain 29 preproprotein	579	Cys-rich.|Extracellular (Potential).				proteolysis|spermatogenesis	integral to plasma membrane	metalloendopeptidase activity|zinc ion binding			skin(5)|central_nervous_system(3)|ovary(3)|large_intestine(2)|lung(2)|pancreas(1)	16		Breast(14;0.00908)|Melanoma(52;0.00951)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;3.08e-19)|Epithelial(43;6.24e-18)|OV - Ovarian serous cystadenocarcinoma(60;1.78e-09)|STAD - Stomach adenocarcinoma(60;0.00303)|GBM - Glioblastoma multiforme(59;0.0106)|LUSC - Lung squamous cell carcinoma(193;0.0286)		TTCAATGACATAATGTGCTGG	0.423	Ovarian(140;1727 1835 21805 25838 41440)		NA											10	86					0	0	0.013537	0	0
IRX2	153572	broad.mit.edu	37	5	2748737	2748737	+	Nonsense_Mutation	SNP	G	G	C			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr5:2748737G>C	uc003jda.2	-	3	1327	c.1085C>G	c.(1084-1086)TCA>TGA	p.S362*	IRX2_uc003jdb.2_Nonsense_Mutation_p.S362*	NM_001134222	NP_001127694	Q9BZI1	IRX2_HUMAN	iroquois homeobox 2	362						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			skin(1)	1				GBM - Glioblastoma multiforme(108;0.204)		TGCCCCGGTTGAggccggcgc	0.507			NA											3	11					0	0	0.001168	0	0
ADAMTS16	170690	broad.mit.edu	37	5	5303476	5303476	+	Missense_Mutation	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr5:5303476C>T	uc003jdl.2	+	19	3023	c.2885C>T	c.(2884-2886)TCG>TTG	p.S962L	ADAMTS16_uc003jdk.1_Missense_Mutation_p.S962L	NM_139056	NP_620687	Q8TE57	ATS16_HUMAN	ADAM metallopeptidase with thrombospondin type 1	962	TSP type-1 3.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(3)|lung(2)|large_intestine(1)|breast(1)|pancreas(1)	8						CACTATGACTCGGAGCCAGTC	0.711			NA											4	5					0	0	0.000602	0	0
CMBL	134147	broad.mit.edu	37	5	10288575	10288575	+	Silent	SNP	G	G	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr5:10288575G>A	uc003jes.2	-	3	733	c.282C>T	c.(280-282)TTC>TTT	p.F94F		NM_138809	NP_620164	Q96DG6	CMBL_HUMAN	carboxymethylenebutenolidase	94						cytosol	hydrolase activity|protein binding			skin(1)	1						GCCACTCAGGGAAGATAGACC	0.507			NA											19	44					0	0	0.012319	0	0
CTNND2	1501	broad.mit.edu	37	5	11082809	11082809	+	Silent	SNP	G	G	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr5:11082809G>T	uc003jfa.1	-	16	2932	c.2787C>A	c.(2785-2787)ATC>ATA	p.I929I	CTNND2_uc010itt.2_Silent_p.I838I|CTNND2_uc011cmy.1_Silent_p.I592I|CTNND2_uc011cmz.1_Silent_p.I496I|CTNND2_uc010itu.1_RNA|CTNND2_uc011cmx.1_Silent_p.I521I	NM_001332	NP_001323	Q9UQB3	CTND2_HUMAN	catenin (cadherin-associated protein), delta 2	929					multicellular organismal development|neuron cell-cell adhesion|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	adherens junction|cytoplasm|nucleus	protein binding			large_intestine(2)|ovary(2)|skin(2)|pancreas(1)|lung(1)	8						AGAACATACCGATGAGCTCCT	0.507			NA											19	57					2.94398e-08	3.5067e-08	0.007413	1	0
FBXL7	23194	broad.mit.edu	37	5	15928326	15928326	+	Missense_Mutation	SNP	G	G	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr5:15928326G>T	uc003jfn.1	+	3	936	c.455G>T	c.(454-456)CGG>CTG	p.R152L		NM_012304	NP_036436	Q9UJT9	FBXL7_HUMAN	F-box and leucine-rich repeat protein 7	152	F-box.				ubiquitin-dependent protein catabolic process	ubiquitin ligase complex	protein binding|ubiquitin-protein ligase activity	p.R152W(1)		ovary(2)|lung(1)	3						TGGGACCCGCGGCTCTGGAGG	0.662			NA											5	12					1.6384e-10	2.01778e-10	0.001984	1	0
FBXL7	23194	broad.mit.edu	37	5	15936692	15936692	+	Silent	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr5:15936692C>T	uc003jfn.1	+	4	1354	c.873C>T	c.(871-873)CAC>CAT	p.H291H		NM_012304	NP_036436	Q9UJT9	FBXL7_HUMAN	F-box and leucine-rich repeat protein 7	291	LRR 5.				ubiquitin-dependent protein catabolic process	ubiquitin ligase complex	protein binding|ubiquitin-protein ligase activity			ovary(2)|lung(1)	3						AAGGCCTGCACACCATCGCGG	0.622			NA											6	35					0	0	0.001168	0	0
CDH12	1010	broad.mit.edu	37	5	21760782	21760782	+	Missense_Mutation	SNP	T	T	C			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr5:21760782T>C	uc010iuc.2	-	10	1976	c.1518A>G	c.(1516-1518)ATA>ATG	p.I506M	CDH12_uc011cno.1_Missense_Mutation_p.I466M|CDH12_uc003jgk.2_Missense_Mutation_p.I506M|uc003jgj.2_Intron	NM_004061	NP_004052	P55289	CAD12_HUMAN	cadherin 12, type 2 preproprotein	506	Extracellular (Potential).|Cadherin 5.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)	2						CTATCTGAATTATCTGCAACA	0.403			NA								HNSCC(59;0.17)			16	33					0	0	0.003163	0	0
CDH10	1008	broad.mit.edu	37	5	24593464	24593464	+	Missense_Mutation	SNP	C	C	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr5:24593464C>A	uc003jgr.1	-	2	468	c.136G>T	c.(136-138)GGC>TGC	p.G46C	CDH10_uc011cnu.1_RNA	NM_006727	NP_006718	Q9Y6N8	CAD10_HUMAN	cadherin 10, type 2 preproprotein	46					adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(6)|pancreas(4)|breast(2)	12				STAD - Stomach adenocarcinoma(35;0.0556)		AGAATTTTGCCATCACTCCTT	0.418			NA								HNSCC(23;0.051)			7	22					0.00198382	0.00206488	0.001984	1	0
ADAMTS12	81792	broad.mit.edu	37	5	33527444	33527444	+	Missense_Mutation	SNP	G	G	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr5:33527444G>A	uc003jia.1	-	24	4797	c.4634C>T	c.(4633-4635)TCA>TTA	p.S1545L	ADAMTS12_uc010iuq.1_Missense_Mutation_p.S1460L	NM_030955	NP_112217	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1	1545	PLAC.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|kidney(1)	9						GAAACTGGCTGACAGTTTGTC	0.438			NA								HNSCC(64;0.19)			11	43					0	0	0.010729	0	0
SLC45A2	51151	broad.mit.edu	37	5	33947350	33947350	+	Missense_Mutation	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr5:33947350C>T	uc003jid.2	-	6	1378	c.1286G>A	c.(1285-1287)AGC>AAC	p.S429N	SLC45A2_uc003jie.2_Missense_Mutation_p.S429N	NM_016180	NP_057264	Q9UMX9	S45A2_HUMAN	membrane-associated transporter protein isoform	429	Helical; Name=10; (Potential).				melanin biosynthetic process|response to stimulus|transmembrane transport|visual perception	integral to membrane|melanosome membrane				ovary(2)|haematopoietic_and_lymphoid_tissue(1)	3						ACCAAACAGGCTGCACAGGAC	0.507	Ovarian(31;380 859 8490 22203 49048)		NA											27	107					0	0	0.005443	0	0
SPEF2	79925	broad.mit.edu	37	5	35654779	35654779	+	Missense_Mutation	SNP	G	G	C			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr5:35654779G>C	uc003jjo.2	+	7	1040	c.929G>C	c.(928-930)AGA>ACA	p.R310T	SPEF2_uc003jjn.1_Missense_Mutation_p.R310T|SPEF2_uc003jjq.3_Missense_Mutation_p.R310T	NM_024867	NP_079143	Q9C093	SPEF2_HUMAN	KPL2 protein isoform 1	310					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		ATP binding|nucleobase, nucleoside, nucleotide kinase activity|protein dimerization activity			skin(2)|ovary(1)|central_nervous_system(1)	4	all_lung(31;7.56e-05)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			AGGGAGAAAAGACGGCGGAAA	0.388			NA											6	31					0	0	0.001168	0	0
SPEF2	79925	broad.mit.edu	37	5	35776497	35776497	+	Missense_Mutation	SNP	G	G	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr5:35776497G>T	uc003jjo.2	+	29	4328	c.4217G>T	c.(4216-4218)AGT>ATT	p.S1406I	SPEF2_uc003jjp.1_Missense_Mutation_p.S892I|SPEF2_uc003jjr.2_5'UTR	NM_024867	NP_079143	Q9C093	SPEF2_HUMAN	KPL2 protein isoform 1	1406					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		ATP binding|nucleobase, nucleoside, nucleotide kinase activity|protein dimerization activity			skin(2)|ovary(1)|central_nervous_system(1)	4	all_lung(31;7.56e-05)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			GAAATGGCCAGGTAAAGTACT	0.308			NA											8	30					5.68852e-11	7.05961e-11	0.004482	1	0
C6	729	broad.mit.edu	37	5	41149361	41149361	+	Missense_Mutation	SNP	C	C	A	rs115220610	by1000genomes	TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr5:41149361C>A	uc003jmk.2	-	17	2815	c.2605G>T	c.(2605-2607)GAC>TAC	p.D869Y	C6_uc003jml.1_Missense_Mutation_p.D869Y	NM_000065	NP_000056	P13671	CO6_HUMAN	complement component 6 precursor	869	Complement control factor I module 2.|C5b-binding domain.				complement activation, classical pathway|cytolysis|innate immune response	membrane attack complex	protein binding			ovary(3)|central_nervous_system(2)|skin(2)	7		Breast(839;1.07e-05)|Ovarian(839;0.0228)|Lung SC(612;0.0548)|Lung NSC(810;0.128)|all_neural(839;0.157)				TTTTCCCAGTCATAGCAGGTG	0.423			NA											25	125					2.98393e-07	3.46613e-07	0.00278	1	0
C6	729	broad.mit.edu	37	5	41199909	41199909	+	Nonsense_Mutation	SNP	C	C	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr5:41199909C>A	uc003jmk.2	-	4	616	c.406G>T	c.(406-408)GAA>TAA	p.E136*	C6_uc003jml.1_Nonsense_Mutation_p.E136*	NM_000065	NP_000056	P13671	CO6_HUMAN	complement component 6 precursor	136					complement activation, classical pathway|cytolysis|innate immune response	membrane attack complex	protein binding			ovary(3)|central_nervous_system(2)|skin(2)	7		Breast(839;1.07e-05)|Ovarian(839;0.0228)|Lung SC(612;0.0548)|Lung NSC(810;0.128)|all_neural(839;0.157)				TCAGCCTCTTCAATTTTGCAG	0.428			NA											11	35					2.27111e-07	2.64023e-07	0.013537	1	0
PLCXD3	345557	broad.mit.edu	37	5	41381966	41381966	+	Missense_Mutation	SNP	T	T	G			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr5:41381966T>G	uc003jmm.1	-	2	876	c.774A>C	c.(772-774)AAA>AAC	p.K258N		NM_001005473	NP_001005473	Q63HM9	PLCX3_HUMAN	phosphatidylinositol-specific phospholipase C, X	258					intracellular signal transduction|lipid catabolic process		phospholipase C activity|signal transducer activity			skin(2)|urinary_tract(1)|ovary(1)|lung(1)|central_nervous_system(1)	6						TTGCCACCCCTTTGACCACAG	0.358			NA											5	38					0	0	0.001168	0	0
MRPS30	10884	broad.mit.edu	37	5	44811251	44811251	+	Missense_Mutation	SNP	G	G	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr5:44811251G>T	uc003joh.2	+	2	780	c.742G>T	c.(742-744)GCA>TCA	p.A248S	MRPS30_uc003joi.1_RNA	NM_016640	NP_057724	Q9NP92	RT30_HUMAN	mitochondrial ribosomal protein S30	248					apoptosis|translation	mitochondrion|ribosome	structural constituent of ribosome				0	Lung NSC(6;8.08e-07)					CAAGCAACTCGCAGAGGTAAG	0.368			NA											5	26					0.000602214	0.000636401	0.000602	1	0
GPX8	493869	broad.mit.edu	37	5	54456044	54456044	+	Silent	SNP	G	G	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr5:54456044G>A	uc003jpq.2	+	1	61	c.24G>A	c.(22-24)CCG>CCA	p.P8P	CDC20B_uc003jpn.1_Intron|CDC20B_uc010ivu.1_Intron|CDC20B_uc003jpo.1_Intron|CDC20B_uc010ivv.1_Intron|CDC20B_uc003jpp.2_Intron|GPX8_uc003jpr.2_Silent_p.P8P|GPX8_uc003jps.2_RNA|GPX8_uc003jpt.2_Silent_p.P8P	NM_001008397	NP_001008398	Q8TED1	GPX8_HUMAN	glutathione peroxidase 8	8					response to oxidative stress	integral to membrane	glutathione peroxidase activity				0					Glutathione(DB00143)	CAGCTTACCCGCTAAAATGTT	0.443			NA											10	27					0	0	0.008291	0	0
SKIV2L2	23517	broad.mit.edu	37	5	54603803	54603803	+	Translation_Start_Site	SNP	C	C	G			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr5:54603803C>G	uc003jpy.3	+	1	228	c.-38C>G	c.(-40--36)ATCGT>ATGGT		SKIV2L2_uc011cqi.1_Translation_Start_Site|DHX29_uc003jpx.2_5'Flank|DHX29_uc010ivw.2_5'Flank	NM_015360	NP_056175	P42285	SK2L2_HUMAN	superkiller viralicidic activity 2-like 2						maturation of 5.8S rRNA	catalytic step 2 spliceosome|nucleolus	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			ovary(1)|skin(1)	2		Lung NSC(810;0.000744)|Breast(144;0.181)|Prostate(74;0.194)				CGCGGGGCATCGTGGGTAGGA	0.587	Melanoma(2;92 134 23744 29976 33782)		NA											11	65					0	0	0.013537	0	0
SLC38A9	153129	broad.mit.edu	37	5	54960619	54960619	+	Missense_Mutation	SNP	G	G	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr5:54960619G>A	uc003jqf.2	-	8	800	c.599C>T	c.(598-600)TCG>TTG	p.S200L	SLC38A9_uc003jqd.2_Missense_Mutation_p.S137L|SLC38A9_uc010ivx.2_Missense_Mutation_p.S173L|SLC38A9_uc003jqe.2_RNA|SLC38A9_uc010ivy.2_Missense_Mutation_p.S71L	NM_173514	NP_775785	Q8NBW4	S38A9_HUMAN	solute carrier family 38, member 9	200	Helical; (Potential).				amino acid transport|sodium ion transport	integral to membrane					0		Lung NSC(810;0.00122)|Prostate(74;0.0376)|Breast(144;0.181)				AAGGAGACTCGACCACTGCCC	0.368			NA											3	25					0	0	0.009096	0	0
ANKRD55	79722	broad.mit.edu	37	5	55407437	55407437	+	Missense_Mutation	SNP	C	C	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr5:55407437C>A	uc003jqu.2	-	10	1290	c.1138G>T	c.(1138-1140)GAC>TAC	p.D380Y	ANKRD55_uc003jqt.2_Missense_Mutation_p.D92Y	NM_024669	NP_078945	Q3KP44	ANR55_HUMAN	ankyrin repeat domain 55 isoform 1	379										skin(1)	1		Lung NSC(810;8.69e-05)|Prostate(74;0.00634)|Breast(144;0.0334)|Ovarian(174;0.223)				GTGATGATGTCATTGACTTCT	0.463			NA											40	203					4.44401e-20	5.99694e-20	0.010771	1	0
TRIM23	373	broad.mit.edu	37	5	64910024	64910024	+	Silent	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr5:64910024C>T	uc003jty.2	-	3	353	c.267G>A	c.(265-267)TTG>TTA	p.L89L	TRIM23_uc003jtw.2_Silent_p.L89L|TRIM23_uc003jtx.2_Silent_p.L89L	NM_001656	NP_001647	P36406	TRI23_HUMAN	ADP-ribosylation factor domain protein 1 isoform	89					interspecies interaction between organisms|small GTPase mediated signal transduction	Golgi membrane|lysosomal membrane	enzyme activator activity|GDP binding|GTP binding|GTPase activity|protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(3)|lung(1)	4		Lung NSC(167;3.24e-06)|Prostate(74;0.0138)|Breast(144;0.0433)|Ovarian(174;0.0545)|Colorectal(97;0.234)		Lung(70;0.00473)		AATTTTTTTTCAATCCCCAGA	0.353			NA											4	47					0	0	0.000602	0	0
BDP1	55814	broad.mit.edu	37	5	70806253	70806253	+	Missense_Mutation	SNP	G	G	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr5:70806253G>A	uc003kbp.1	+	17	3597	c.3334G>A	c.(3334-3336)GGT>AGT	p.G1112S	BDP1_uc003kbn.1_Missense_Mutation_p.G1112S|BDP1_uc003kbo.2_Missense_Mutation_p.G1112S	NM_018429	NP_060899	A6H8Y1	BDP1_HUMAN	transcription factor-like nuclear regulator	1112	6.|9 X 55 AA repeats of G-R-R-X-I-S-P-X-E-N- G-X-E-E-V-K-P-X-X-E-M-E-T-D-L-K-X-T-G-R- E-X-X-X-R-E-K-T-X-E-X-X-D-A-X-E-E-I-D-X- D-L-E-E-T.				regulation of transcription, DNA-dependent|transcription from RNA polymerase III promoter	nucleoplasm	DNA binding			skin(2)	2		Lung NSC(167;0.000422)|Prostate(74;0.00815)|Ovarian(174;0.0176)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;5.28e-56)|Epithelial(20;2.31e-50)		TAAGCCTCTAGGTGAAATGCA	0.433			NA											9	31					0	0	0.006214	0	0
DMGDH	29958	broad.mit.edu	37	5	78340326	78340326	+	Silent	SNP	G	G	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr5:78340326G>A	uc003kfs.2	-	6	801	c.795C>T	c.(793-795)CTC>CTT	p.L265L	DMGDH_uc011cte.1_Silent_p.L115L|DMGDH_uc011ctf.1_Silent_p.L64L|DMGDH_uc011ctg.1_Intron	NM_013391	NP_037523	Q9UI17	M2GD_HUMAN	dimethylglycine dehydrogenase precursor	265					choline metabolic process|glycine catabolic process	mitochondrial matrix	aminomethyltransferase activity|dimethylglycine dehydrogenase activity|electron carrier activity			ovary(2)|liver(1)|skin(1)	4		all_lung(232;0.000638)|Lung NSC(167;0.00173)|Ovarian(174;0.0262)|Prostate(461;0.192)		OV - Ovarian serous cystadenocarcinoma(54;6.52e-45)|Epithelial(54;5.96e-40)|all cancers(79;3.56e-35)		GAACCGGAATGAGAGGATGTT	0.373			NA											13	32					0	0	0.013537	0	0
BHMT	635	broad.mit.edu	37	5	78422045	78422045	+	Missense_Mutation	SNP	C	C	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr5:78422045C>A	uc003kfu.3	+	6	907	c.802C>A	c.(802-804)CCA>ACA	p.P268T	BHMT_uc011cti.1_Missense_Mutation_p.P115T	NM_001713	NP_001704	Q93088	BHMT1_HUMAN	betaine-homocysteine methyltransferase	268	Hcy-binding.				protein methylation|regulation of homocysteine metabolic process	cytoplasm	betaine-homocysteine S-methyltransferase activity|homocysteine S-methyltransferase activity|zinc ion binding			ovary(1)	1		all_lung(232;0.00051)|Lung NSC(167;0.00131)|Ovarian(174;0.0261)|Prostate(461;0.191)		OV - Ovarian serous cystadenocarcinoma(54;1.88e-45)|Epithelial(54;8.07e-41)|all cancers(79;3.51e-36)	L-Methionine(DB00134)	CCCAGAATTCCCATTTGGTAA	0.433			NA											7	31					1.06961e-07	1.25857e-07	0.00308	1	0
SPZ1	84654	broad.mit.edu	37	5	79616095	79616095	+	Missense_Mutation	SNP	C	C	G			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr5:79616095C>G	uc003kgn.2	+	1	306	c.61C>G	c.(61-63)CCT>GCT	p.P21A	uc011ctk.1_RNA	NM_032567	NP_115956	Q9BXG8	SPZ1_HUMAN	spermatogenic leucine zipper 1	21					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding			ovary(1)	1		Lung NSC(167;0.0393)|all_lung(232;0.0428)|Ovarian(174;0.113)		OV - Ovarian serous cystadenocarcinoma(54;3.43e-47)|Epithelial(54;2.25e-41)|all cancers(79;4.19e-36)		TAACCCTACTCCTGATCCTCA	0.473			NA											31	135					0	0	0.013726	0	0
ANKRD34B	340120	broad.mit.edu	37	5	79855043	79855043	+	Missense_Mutation	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr5:79855043C>T	uc010jam.2	-	4	1146	c.796G>A	c.(796-798)GAG>AAG	p.E266K	ANKRD34B_uc003kgw.2_Missense_Mutation_p.E266K|ANKRD34B_uc010jan.2_Missense_Mutation_p.E266K	NM_001004441	NP_001004441	A5PLL1	AN34B_HUMAN	ankyrin repeat domain 34B	266						cytoplasm|nucleus				pancreas(1)	1		Lung NSC(167;0.0427)|all_lung(232;0.0464)|Ovarian(174;0.113)		OV - Ovarian serous cystadenocarcinoma(54;2.17e-46)|Epithelial(54;5.64e-41)|all cancers(79;3.24e-36)		TGGAGCTCCTCTTGCAATGAA	0.517			NA											7	52					0	0	0.001984	0	0
PJA2	9867	broad.mit.edu	37	5	108714382	108714382	+	Missense_Mutation	SNP	T	T	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr5:108714382T>A	uc003kos.3	-	4	1026	c.806A>T	c.(805-807)CAA>CTA	p.Q269L		NM_014819	NP_055634	O43164	PJA2_HUMAN	praja 2, RING-H2 motif containing	269					long-term memory|regulation of protein kinase A signaling cascade	cell junction|endoplasmic reticulum membrane|Golgi membrane|postsynaptic density|postsynaptic membrane	ligase activity|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|zinc ion binding			ovary(1)|skin(1)	2		all_cancers(142;4.4e-06)|all_epithelial(76;8.17e-08)|Prostate(80;0.00676)|Lung NSC(167;0.0436)|Ovarian(225;0.0443)|all_lung(232;0.053)|Colorectal(57;0.0946)|Breast(839;0.151)		OV - Ovarian serous cystadenocarcinoma(64;3.46e-10)|Epithelial(69;6.02e-09)|COAD - Colon adenocarcinoma(37;0.224)		ATTATTTTGTTGTTTCGTACT	0.403			NA											13	46					0	0	0.013537	0	0
EPB41L4A	64097	broad.mit.edu	37	5	111519791	111519791	+	Missense_Mutation	SNP	C	C	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr5:111519791C>A	uc003kpv.1	-	18	1818	c.1544G>T	c.(1543-1545)TGG>TTG	p.W515L	EPB41L4A_uc003kpp.1_Missense_Mutation_p.W142L	NM_022140	NP_071423	Q9HCS5	E41LA_HUMAN	erythrocyte protein band 4.1-like 4	515						cytoplasm|cytoskeleton|extrinsic to membrane	cytoskeletal protein binding			ovary(1)	1		all_cancers(142;4.93e-06)|all_epithelial(76;2.28e-08)|Prostate(80;0.000244)|Colorectal(10;0.000788)|Ovarian(225;0.0448)|Lung NSC(167;0.126)|all_lung(232;0.135)		OV - Ovarian serous cystadenocarcinoma(64;6.24e-09)|Epithelial(69;1.43e-07)|all cancers(49;2.78e-05)|COAD - Colon adenocarcinoma(37;0.0467)|Colorectal(14;0.0791)		TACAGCTTCCCACTGAGGCGC	0.453			NA											9	34					0.00829132	0.00852017	0.008291	1	0
MCC	4163	broad.mit.edu	37	5	112406907	112406907	+	Silent	SNP	T	T	C			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr5:112406907T>C	uc003kqj.3	-	10	1769	c.1239A>G	c.(1237-1239)CAA>CAG	p.Q413Q	MCC_uc003kqk.3_RNA|MCC_uc003kql.3_Silent_p.Q603Q|MCC_uc011cwb.1_Silent_p.Q413Q|MCC_uc010jcd.1_Silent_p.Q375Q	NM_002387	NP_002378	P23508	CRCM_HUMAN	mutated in colorectal cancers isoform 2	413					negative regulation of canonical Wnt receptor signaling pathway|negative regulation of epithelial cell migration|negative regulation of epithelial cell proliferation|Wnt receptor signaling pathway	cytoplasm|nucleus|plasma membrane	protein binding|receptor activity			ovary(1)	1		all_cancers(142;5.89e-08)|all_epithelial(76;3.57e-11)|all_lung(232;0.000605)|Lung NSC(810;0.000697)|Colorectal(10;0.00146)|Prostate(80;0.00174)|Ovarian(225;0.0175)|Breast(839;0.198)		OV - Ovarian serous cystadenocarcinoma(64;2.04e-54)|Epithelial(69;9.69e-49)|all cancers(49;6.25e-44)|COAD - Colon adenocarcinoma(37;0.0432)|Colorectal(14;0.0766)		GGAGGTCATTTTGGGATTTGA	0.428			NA											26	92					0	0	0.005443	0	0
FEM1C	56929	broad.mit.edu	37	5	114879140	114879140	+	Silent	SNP	C	C	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr5:114879140C>A	uc003krb.1	-	2	613	c.51G>T	c.(49-51)CGG>CGT	p.R17R		NM_020177	NP_064562	Q96JP0	FEM1C_HUMAN	feminization 1 homolog a	17	ANK 1.					cytoplasm				breast(2)|ovary(1)	3		all_cancers(142;0.000575)|all_epithelial(76;9.98e-06)|Prostate(80;0.00955)|Ovarian(225;0.0443)|all_lung(232;0.132)|Breast(839;0.195)		OV - Ovarian serous cystadenocarcinoma(64;2.5e-07)|Epithelial(69;2.66e-07)|all cancers(49;1.39e-05)		TGGTGAGAAGCCGGAGTTTGC	0.468			NA											12	48					5.50884e-06	6.16718e-06	0.013537	1	0
AQPEP	206338	broad.mit.edu	37	5	115298888	115298888	+	Missense_Mutation	SNP	C	C	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr5:115298888C>A	uc003kro.2	+	1	738	c.574C>A	c.(574-576)CTC>ATC	p.L192I	AQPEP_uc003krp.2_RNA|uc003krn.1_5'UTR	NM_173800	NP_776161	Q6Q4G3	AMPQ_HUMAN	laeverin	192	Lumenal (Potential).				proteolysis	integral to membrane	metallopeptidase activity|zinc ion binding				0						GGTGCTGGAGCTCAGTGAGCC	0.632			NA											8	23					0.000274275	0.000292399	0.004482	1	0
FBN2	2201	broad.mit.edu	37	5	127728854	127728854	+	Missense_Mutation	SNP	C	C	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr5:127728854C>A	uc003kuu.2	-	10	1878	c.1439G>T	c.(1438-1440)GGA>GTA	p.G480V	FBN2_uc003kuv.2_Missense_Mutation_p.G447V	NM_001999	NP_001990	P35556	FBN2_HUMAN	fibrillin 2 precursor	480					bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			ovary(8)|large_intestine(4)|pancreas(1)|kidney(1)|skin(1)	15		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)		AGGTCCCTGTCCCCCGGCCCC	0.512			NA											18	77					9.7654e-05	0.000105501	0.007413	1	0
TRPC7	57113	broad.mit.edu	37	5	135651315	135651315	+	Silent	SNP	G	G	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr5:135651315G>T	uc003lbn.1	-	2	933	c.930C>A	c.(928-930)ATC>ATA	p.I310I	TRPC7_uc010jef.1_Silent_p.I302I|TRPC7_uc010jeg.1_RNA|TRPC7_uc010jeh.1_Intron|TRPC7_uc010jei.1_Intron|TRPC7_uc010jej.1_Intron	NM_020389	NP_065122	Q9HCX4	TRPC7_HUMAN	transient receptor potential cation channel,	311	Cytoplasmic (Potential).				axon guidance|platelet activation	integral to membrane|plasma membrane	calcium channel activity|protein binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			TGGCGAGTTTGATCCGGCTCA	0.517			NA											7	23					1.12685e-05	1.25378e-05	0.004482	1	0
ANKHD1-EIF4EBP3	404734	broad.mit.edu	37	5	139909060	139909060	+	Missense_Mutation	SNP	G	G	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr5:139909060G>T	uc003lfs.1	+	29	6653	c.6529G>T	c.(6529-6531)GTG>TTG	p.V2177L	ANKHD1_uc003lfr.2_Missense_Mutation_p.V2177L|ANKHD1-EIF4EBP3_uc011czh.1_Missense_Mutation_p.V916L|ANKHD1_uc003lfw.2_Missense_Mutation_p.V815L|ANKHD1_uc010jfl.2_Missense_Mutation_p.V612L|ANKHD1-EIF4EBP3_uc003lfx.1_Missense_Mutation_p.V314L	NM_020690	NP_065741	Q8IWZ2	Q8IWZ2_HUMAN	ANKHD1-EIF4EBP3 protein	2177						cytoplasm|nucleus	RNA binding			ovary(6)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ACCAGCTGCAGTGCAGCTTTC	0.443			NA											25	99					4.26978e-12	5.40045e-12	0.00333	1	0
PCDHA4	56144	broad.mit.edu	37	5	140189081	140189081	+	Missense_Mutation	SNP	T	T	C			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr5:140189081T>C	uc003lhi.2	+	1	2410	c.2309T>C	c.(2308-2310)ATG>ACG	p.M770T	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhh.1_Missense_Mutation_p.M770T|PCDHA4_uc011daa.1_Missense_Mutation_p.M770T	NM_018907	NP_061730	Q9UN74	PCDA4_HUMAN	protocadherin alpha 4 isoform 1 precursor	770	Cytoplasmic (Potential).|6 X 4 AA repeats of P-X-X-P.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			ovary(4)|skin(2)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ACCGACCTCATGGCCTTCAGC	0.562			NA											25	74					0	0	0.003954	0	0
PCDHAC1	56135	broad.mit.edu	37	5	140308879	140308879	+	Missense_Mutation	SNP	G	G	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr5:140308879G>A	uc003lih.2	+	1	2578	c.2402G>A	c.(2401-2403)AGG>AAG	p.R801K	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc003lia.2_Intron|PCDHA12_uc003lic.2_Intron|PCDHA13_uc003lie.1_Intron|PCDHA13_uc003lif.2_Intron|PCDHAC1_uc003lig.1_Missense_Mutation_p.R801K	NM_018898	NP_061721	Q9H158	PCDC1_HUMAN	protocadherin alpha subfamily C, 1 isoform 1	801	Cytoplasmic (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			skin(3)|ovary(2)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ATTCGGAATAGGAAAGGGGAT	0.448			NA											15	57					0	0	0.006122	0	0
PCDHB4	56131	broad.mit.edu	37	5	140501728	140501728	+	Missense_Mutation	SNP	G	G	C			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr5:140501728G>C	uc003lip.1	+	1	148	c.148G>C	c.(148-150)GAT>CAT	p.D50H		NM_018938	NP_061761	Q9Y5E5	PCDB4_HUMAN	protocadherin beta 4 precursor	50	Cadherin 1.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	cytoplasm|integral to plasma membrane|intermediate filament cytoskeleton	calcium ion binding			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TCTGGCCAAGGATCTGGGCCT	0.542			NA											8	59					0	0	0.00308	0	0
PCDHB5	26167	broad.mit.edu	37	5	140515957	140515957	+	Missense_Mutation	SNP	A	A	C			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr5:140515957A>C	uc003liq.2	+	1	1158	c.941A>C	c.(940-942)TAT>TCT	p.Y314S		NM_015669	NP_056484	Q9Y5E4	PCDB5_HUMAN	protocadherin beta 5 precursor	314	Cadherin 3.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding|protein binding			skin(3)|ovary(2)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			ACTCCATATTATAACGTGGAA	0.453			NA											25	111					0	0	0.007291	0	0
PCDHB5	26167	broad.mit.edu	37	5	140516601	140516601	+	Missense_Mutation	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr5:140516601C>T	uc003liq.2	+	1	1802	c.1585C>T	c.(1585-1587)CGC>TGC	p.R529C		NM_015669	NP_056484	Q9Y5E4	PCDB5_HUMAN	protocadherin beta 5 precursor	529	Extracellular (Potential).|Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding|protein binding			skin(3)|ovary(2)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GTTCGAGTTCCGCGTGGGAGC	0.682			NA											27	77					0	0	0.004656	0	0
PCDHB8	56128	broad.mit.edu	37	5	140558439	140558439	+	Missense_Mutation	SNP	A	A	G			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr5:140558439A>G	uc011dai.1	+	1	1010	c.824A>G	c.(823-825)AAC>AGC	p.N275S	PCDHB16_uc003liv.2_5'Flank	NM_019120	NP_061993	Q9UN66	PCDB8_HUMAN	protocadherin beta 8 precursor	275	Cadherin 3.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			skin(4)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			ACAGGAGTCAACGGAGAGATT	0.423			NA											30	78					0	0	0.007291	0	0
PCDHB8	56128	broad.mit.edu	37	5	140559471	140559471	+	Missense_Mutation	SNP	G	G	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr5:140559471G>T	uc011dai.1	+	1	2042	c.1856G>T	c.(1855-1857)TGG>TTG	p.W619L	PCDHB16_uc003liv.2_5'Flank|PCDHB16_uc010jfw.1_5'Flank	NM_019120	NP_061993	Q9UN66	PCDB8_HUMAN	protocadherin beta 8 precursor	619	Cadherin 6.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			skin(4)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TTCGGTGTGTGGGCGCACAAT	0.692			NA											16	76					9.17885e-22	1.24791e-21	0.003271	1	0
PCDHB9	56127	broad.mit.edu	37	5	140567886	140567886	+	Missense_Mutation	SNP	A	A	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr5:140567886A>T	uc003liw.1	+	1	994	c.994A>T	c.(994-996)ACA>TCA	p.T332S		NM_019119	NP_061992	Q9Y5E1	PCDB9_HUMAN	protocadherin beta 9 precursor	332	Extracellular (Potential).|Cadherin 3.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TGCAAGATGTACAGTTTTGAT	0.368			NA											7	30					0	0	0.00308	0	0
SLC25A2	83884	broad.mit.edu	37	5	140683365	140683366	+	Missense_Mutation	DNP	CA	CA	TT			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	CA	CA	-	-	CA	CA	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr5:140683365_140683366CA>TT	uc003ljf.2	-	1	247_248	c.67_68TG>AA	c.(67-69)TGT>AAT	p.C23N		NM_031947	NP_114153	Q9BXI2	ORNT2_HUMAN	solute carrier family 25 member 2	23	Helical; Name=1; (Potential).|Solcar 1.				mitochondrial ornithine transport|urea cycle	integral to membrane|mitochondrial inner membrane	L-ornithine transmembrane transporter activity			ovary(1)	1		all_lung(500;0.000249)|Lung NSC(810;0.0011)|Ovarian(839;0.00556)|Breast(839;0.0173)|all_hematologic(541;0.152)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)	GBM - Glioblastoma multiforme(465;0.00204)	L-Ornithine(DB00129)	AGTCAGTACACACGCTGTCCCC	0.599			NA											8	50					0	0	0.004672	0	0
PCDHGB3	56102	broad.mit.edu	37	5	140751805	140751805	+	Missense_Mutation	SNP	G	G	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr5:140751805G>T	uc003ljw.1	+	1	1844	c.1844G>T	c.(1843-1845)GGG>GTG	p.G615V	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGA6_uc003ljy.1_5'Flank|PCDHGB3_uc011dat.1_Missense_Mutation_p.G615V|PCDHGA6_uc011dau.1_5'Flank	NM_018924	NP_061747	Q9Y5G1	PCDGF_HUMAN	protocadherin gamma subfamily B, 3 isoform 1	615	Extracellular (Potential).|Cadherin 6.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGCGAGCCCGGGCTGTTCAGC	0.687			NA											16	88					1.15088e-07	1.34873e-07	0.004007	1	0
PCDHGA7	56108	broad.mit.edu	37	5	140762481	140762481	+	Silent	SNP	G	G	C			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr5:140762481G>C	uc003lka.1	+	1	15	c.15G>C	c.(13-15)CCG>CCC	p.P5P	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003ljz.1_Silent_p.P5P	NM_018920	NP_061743	Q9Y5G6	PCDG7_HUMAN	protocadherin gamma subfamily A, 7 isoform 1	5					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGGCTCAGCCGAGGGGCGGGG	0.612			NA									OREG0016858	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	13	86					0	0	0.004007	0	0
PCDHGB6	56100	broad.mit.edu	37	5	140788971	140788971	+	Missense_Mutation	SNP	A	A	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr5:140788971A>T	uc003lkj.1	+	1	1202	c.1202A>T	c.(1201-1203)TAC>TTC	p.Y401F	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc003lkh.1_Intron|PCDHGB6_uc003lki.1_Missense_Mutation_p.Y401F	NM_018926	NP_061749	Q9Y5F9	PCDGI_HUMAN	protocadherin gamma subfamily B, 6 isoform 1	401	Extracellular (Potential).|Cadherin 4.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCCAATAACTACTACAAACTG	0.458			NA											13	33					0	0	0.013537	0	0
PCDHGB6	56100	broad.mit.edu	37	5	140789165	140789165	+	Missense_Mutation	SNP	C	C	G			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr5:140789165C>G	uc003lkj.1	+	1	1396	c.1396C>G	c.(1396-1398)CCG>GCG	p.P466A	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc003lkh.1_Intron|PCDHGB6_uc003lki.1_Missense_Mutation_p.P466A	NM_018926	NP_061749	Q9Y5F9	PCDGI_HUMAN	protocadherin gamma subfamily B, 6 isoform 1	466	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGAGAACAACCCGCCAGGAGC	0.567			NA											10	44					0	0	0.006214	0	0
PCDHGA12	26025	broad.mit.edu	37	5	140811320	140811320	+	Missense_Mutation	SNP	A	A	G			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr5:140811320A>G	uc003lkt.1	+	1	1163	c.994A>G	c.(994-996)AAA>GAA	p.K332E	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc003lkh.1_Intron|PCDHGB6_uc003lkj.1_Intron|PCDHGA10_uc003lkl.1_Intron|PCDHGB7_uc003lkn.1_Intron|PCDHGA11_uc003lkp.1_Intron|PCDHGA11_uc003lkq.1_Intron|PCDHGA12_uc011dba.1_Missense_Mutation_p.K332E	NM_003735	NP_003726	O60330	PCDGC_HUMAN	protocadherin gamma subfamily A, 12 isoform 1	332	Cadherin 3.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)|pancreas(1)|skin(1)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGCGCGAGCCAAAGTCCTGAT	0.517			NA											22	76					0	0	0.00278	0	0
PCDHGC4	56098	broad.mit.edu	37	5	140864842	140864842	+	Silent	SNP	G	G	T	rs77402299		TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr5:140864842G>T	uc003lky.1	+	1	102	c.102G>T	c.(100-102)CCG>CCT	p.P34P	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc003lkh.1_Intron|PCDHGB6_uc003lkj.1_Intron|PCDHGA10_uc003lkl.1_Intron|PCDHGB7_uc003lkn.1_Intron|PCDHGA11_uc003lkp.1_Intron|PCDHGA11_uc003lkq.1_Intron|PCDHGA12_uc003lkt.1_Intron|PCDHGC3_uc003lkv.1_Intron|PCDHGC3_uc003lkw.1_Intron|PCDHGC4_uc011dbb.1_Silent_p.P34P	NM_018928	NP_061751	Q9Y5F7	PCDGL_HUMAN	protocadherin gamma subfamily C, 4 isoform 1	34	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCCGCTACCCGGTCCCAGAGG	0.557			NA											15	56					1.15088e-07	1.34873e-07	0.004007	1	0
PCDH1	5097	broad.mit.edu	37	5	141233739	141233739	+	Missense_Mutation	SNP	G	G	C			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr5:141233739G>C	uc003llp.2	-	5	3699	c.3582C>G	c.(3580-3582)TTC>TTG	p.F1194L		NM_032420	NP_115796	Q08174	PCDH1_HUMAN	protocadherin 1 isoform 2 precursor	Error:Variant_position_missing_in_Q08174_after_alignment					cell-cell signaling|homophilic cell adhesion|nervous system development	cell-cell junction|integral to plasma membrane	calcium ion binding			ovary(5)	5		Lung NSC(810;0.027)|all_lung(500;0.0321)|all_hematologic(541;0.0433)|Prostate(461;0.0453)|Breast(839;0.128)|Lung SC(612;0.238)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)	GBM - Glioblastoma multiforme(465;1.06e-05)		TACTGTGGGAGAAGGCACTGT	0.677	Ovarian(132;1609 1739 4190 14731 45037)		NA											6	15					0	0	0.001168	0	0
KIAA0141	9812	broad.mit.edu	37	5	141318258	141318258	+	Silent	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr5:141318258C>T	uc003lls.2	+	12	1604	c.1482C>T	c.(1480-1482)TCC>TCT	p.S494S	KIAA0141_uc003llt.2_Silent_p.S494S|KIAA0141_uc003llu.1_RNA	NM_001142603	NP_001136075	Q14154	DELE_HUMAN	hypothetical protein LOC9812 precursor	494	TPR 7.				apoptosis|regulation of caspase activity	mitochondrion	protein binding			skin(1)	1		all_hematologic(541;0.118)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGGAAGCCTCCAGCAGGGCTA	0.567			NA											11	103					0	0	0.010729	0	0
LARS	51520	broad.mit.edu	37	5	145537160	145537160	+	Missense_Mutation	SNP	C	C	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr5:145537160C>A	uc003lnx.1	-	10	1109	c.871G>T	c.(871-873)GCT>TCT	p.A291S	LARS_uc011dbq.1_Missense_Mutation_p.A245S|LARS_uc011dbr.1_Missense_Mutation_p.A237S|LARS_uc011dbs.1_Missense_Mutation_p.A264S	NM_020117	NP_064502	Q9P2J5	SYLC_HUMAN	leucyl-tRNA synthetase	291	Editing domain.				leucyl-tRNA aminoacylation	cytosol	ATP binding|leucine-tRNA ligase activity|protein binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)		L-Leucine(DB00149)	AGAGTAGCAGCCACCAAGAAA	0.373			NA											7	21					2.0095e-06	2.28488e-06	0.001984	1	0
LARS	51520	broad.mit.edu	37	5	145537167	145537167	+	Silent	SNP	G	G	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr5:145537167G>A	uc003lnx.1	-	10	1102	c.864C>T	c.(862-864)TTC>TTT	p.F288F	LARS_uc011dbq.1_Silent_p.F242F|LARS_uc011dbr.1_Silent_p.F234F|LARS_uc011dbs.1_Silent_p.F261F	NM_020117	NP_064502	Q9P2J5	SYLC_HUMAN	leucyl-tRNA synthetase	288	Editing domain.				leucyl-tRNA aminoacylation	cytosol	ATP binding|leucine-tRNA ligase activity|protein binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)		L-Leucine(DB00149)	CAGCCACCAAGAAAATATTTT	0.378			NA											6	19					0	0	0.001168	0	0
ARHGEF37	389337	broad.mit.edu	37	5	149001437	149001437	+	Missense_Mutation	SNP	A	A	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr5:149001437A>T	uc003lra.1	+	9	1211	c.1147A>T	c.(1147-1149)AGT>TGT	p.S383C		NM_001001669	NP_001001669	A1IGU5	ARH37_HUMAN	hypothetical protein LOC389337	383	BAR.				regulation of Rho protein signal transduction	cytoplasm	Rho guanyl-nucleotide exchange factor activity				0						GGAGGTGGGCAGTGTGACCTA	0.592			NA											21	58					0	0	0.00278	0	0
PDE6A	5145	broad.mit.edu	37	5	149274852	149274852	+	Missense_Mutation	SNP	G	G	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr5:149274852G>T	uc003lrg.3	-	13	1742	c.1622C>A	c.(1621-1623)GCC>GAC	p.A541D		NM_000440	NP_000431	P16499	PDE6A_HUMAN	phosphodiesterase 6A	541					cytosolic calcium ion homeostasis|GMP metabolic process|platelet activation|signal transduction|visual perception	cytosol|plasma membrane	3',5'-cyclic-GMP phosphodiesterase activity|metal ion binding			ovary(1)|pancreas(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.000962)|Kidney(363;0.00147)			CCGCACCAGGGCCTGTGAACA	0.542			NA											7	36					0.00198382	0.00206488	0.001984	1	0
CSF1R	1436	broad.mit.edu	37	5	149433914	149433914	+	Nonsense_Mutation	SNP	C	C	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr5:149433914C>A	uc003lrl.2	-	20	2929	c.2734G>T	c.(2734-2736)GAG>TAG	p.E912*	CSF1R_uc011dcd.1_Intron|CSF1R_uc010jhc.2_RNA|CSF1R_uc003lrm.2_Nonsense_Mutation_p.E912*	NM_005211	NP_005202	P07333	CSF1R_HUMAN	colony stimulating factor 1 receptor precursor	912	Cytoplasmic (Potential).				cell proliferation|multicellular organismal development|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane|receptor complex	ATP binding|cytokine binding|macrophage colony-stimulating factor receptor activity|protein homodimerization activity			haematopoietic_and_lymphoid_tissue(38)|lung(6)|central_nervous_system(3)|liver(3)|breast(2)|endometrium(1)|ovary(1)	54			KIRC - Kidney renal clear cell carcinoma(527;0.000962)|Kidney(363;0.00147)		Imatinib(DB00619)|Sunitinib(DB01268)	TGGGCCTGCTCCTGAAGGAAG	0.612			NA											21	75					1.9806e-07	2.31548e-07	0.014323	1	0
TCOF1	6949	broad.mit.edu	37	5	149749093	149749093	+	Silent	SNP	G	G	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr5:149749093G>A	uc003lry.2	+	6	675	c.567G>A	c.(565-567)GGG>GGA	p.G189G	TCOF1_uc003lrw.2_Silent_p.G189G|TCOF1_uc011dch.1_Silent_p.G189G|TCOF1_uc003lrz.2_Silent_p.G189G|TCOF1_uc003lrx.2_Silent_p.G189G|TCOF1_uc003lsa.2_Silent_p.G189G	NM_001135243	NP_001128715	Q13428	TCOF_HUMAN	Treacher Collins-Franceschetti syndrome 1	189					skeletal system development	nucleolus	protein binding|transporter activity			ovary(2)|large_intestine(1)	3		all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			GATCCTCAGGGATGGTGTCAG	0.627			NA											16	49					0	0	0.007413	0	0
FAT2	2196	broad.mit.edu	37	5	150924904	150924904	+	Silent	SNP	C	C	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr5:150924904C>A	uc003lue.3	-	9	5797	c.5784G>T	c.(5782-5784)CTG>CTT	p.L1928L	GM2A_uc011dcs.1_Intron	NM_001447	NP_001438	Q9NYQ8	FAT2_HUMAN	FAT tumor suppressor 2 precursor	1928	Extracellular (Potential).				epithelial cell migration|homophilic cell adhesion	cell-cell adherens junction|integral to membrane|nucleus	calcium ion binding			ovary(4)|upper_aerodigestive_tract(1)|skin(1)	6		Medulloblastoma(196;0.0912)|all_hematologic(541;0.104)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			AAGCAGGATTCAGCACAGATA	0.478			NA											25	85					1.64293e-13	2.1111e-13	0.00333	1	0
G3BP1	10146	broad.mit.edu	37	5	151170615	151170615	+	Missense_Mutation	SNP	G	G	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr5:151170615G>T	uc003lun.2	+	4	514	c.343G>T	c.(343-345)GCT>TCT	p.A115S	G3BP1_uc010jhy.1_Missense_Mutation_p.A115S|G3BP1_uc003lum.2_Missense_Mutation_p.A115S|G3BP1_uc011dcu.1_5'UTR|G3BP1_uc010jhz.2_5'UTR	NM_005754	NP_005745	Q13283	G3BP1_HUMAN	Ras-GTPase-activating protein SH3-domain-binding	115	NTF2.				Ras protein signal transduction|transport	cytosol|nucleus|plasma membrane	ATP binding|ATP-dependent DNA helicase activity|ATP-dependent RNA helicase activity|DNA binding|endonuclease activity|protein binding|RNA binding			skin(3)|ovary(1)	4		all_hematologic(541;0.0338)|Medulloblastoma(196;0.091)	Kidney(363;0.000171)|KIRC - Kidney renal clear cell carcinoma(527;0.000785)			GTTTGTCCTTGCTCCTGAGGT	0.393			NA											8	36					5.18039e-06	5.81293e-06	0.00308	1	0
GALNT10	55568	broad.mit.edu	37	5	153796519	153796519	+	Missense_Mutation	SNP	T	T	G			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr5:153796519T>G	uc003lvh.2	+	12	1931	c.1799T>G	c.(1798-1800)TTC>TGC	p.F600C	GALNT10_uc010jic.2_RNA|GALNT10_uc010jid.2_Missense_Mutation_p.F441C|uc003lvi.2_Intron|GALNT10_uc003lvj.2_Missense_Mutation_p.F271C	NM_198321	NP_938080	Q86SR1	GLT10_HUMAN	GalNAc transferase 10 isoform a	600	Lumenal (Potential).					Golgi membrane|integral to membrane	metal ion binding|polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			skin(2)	2	Renal(175;0.00488)	Medulloblastoma(196;0.0354)|all_neural(177;0.147)|all_hematologic(541;0.21)	Kidney(363;8.21e-05)|KIRC - Kidney renal clear cell carcinoma(527;0.000577)			TTGGAAAAATTCAATAGGAAC	0.542			NA											19	59					0	0	0.007413	0	0
HAVCR1	26762	broad.mit.edu	37	5	156482498	156482498	+	Silent	SNP	A	A	G			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr5:156482498A>G	uc010jij.1	-	3	278	c.93T>C	c.(91-93)TCT>TCC	p.S31S	HAVCR1_uc011ddl.1_5'Flank|HAVCR1_uc003lwi.2_Silent_p.S31S|HAVCR1_uc011ddm.1_Silent_p.S31S	NM_001099414	NP_001092884	Q96D42	HAVR1_HUMAN	hepatitis A virus cellular receptor 1	31	Extracellular (Potential).|Ig-like V-type.				interspecies interaction between organisms	integral to membrane	receptor activity			ovary(1)|skin(1)	2	Renal(175;0.00488)	Medulloblastoma(196;0.0354)|all_neural(177;0.0999)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			GTAGTGTGACAGATGGACCTG	0.453			NA											4	15					0	0	0.000602	0	0
THG1L	54974	broad.mit.edu	37	5	157158442	157158442	+	Translation_Start_Site	SNP	G	G	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr5:157158442G>A	uc003lxd.2	+	1	120	c.-6G>A	c.(-8--4)GCGTG>GCATG		THG1L_uc011ddu.1_Translation_Start_Site	NM_017872	NP_060342	Q9NWX6	THG1_HUMAN	interphase cytoplasmic foci protein 45						protein homotetramerization|tRNA modification	mitochondrion	GTP binding|metal ion binding|tRNA guanylyltransferase activity				0	Renal(175;0.00488)	Medulloblastoma(196;0.0523)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			TCCTTTCCGCGTGTAGAATGT	0.562			NA											11	29					0	0	0.010729	0	0
DOCK2	1794	broad.mit.edu	37	5	169267790	169267790	+	Missense_Mutation	SNP	C	C	G			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr5:169267790C>G	uc003maf.2	+	27	2813	c.2733C>G	c.(2731-2733)ATC>ATG	p.I911M	DOCK2_uc011der.1_RNA|DOCK2_uc010jjm.2_Missense_Mutation_p.I403M	NM_004946	NP_004937	Q92608	DOCK2_HUMAN	dedicator of cytokinesis 2	911					actin cytoskeleton organization|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|endomembrane system|membrane	electron carrier activity|GTP binding|GTPase binding|heme binding|Rac guanyl-nucleotide exchange factor activity|T cell receptor binding			ovary(5)|pancreas(2)	7	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			TCCAGGAGATCATGGTCCAGC	0.473			NA											3	30					0	0	0.004672	0	0
NKX2-5	1482	broad.mit.edu	37	5	172659655	172659655	+	Missense_Mutation	SNP	C	C	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr5:172659655C>A	uc003mcm.1	-	2	1068	c.892G>T	c.(892-894)GGG>TGG	p.G298W		NM_004387	NP_004378	P52952	NKX25_HUMAN	NK2 transcription factor related, locus 5	298					adult heart development|atrial cardiac muscle cell development|atrial septum morphogenesis|heart looping|hemopoiesis|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cardiac muscle cell apoptosis|negative regulation of myotube differentiation|negative regulation of transcription from RNA polymerase II promoter|outflow tract septum morphogenesis|pharyngeal system development|positive regulation of calcium ion transport via voltage-gated calcium channel activity|positive regulation of cardioblast differentiation|positive regulation of cell proliferation|positive regulation of heart contraction|positive regulation of neuron differentiation|positive regulation of sodium ion transport|positive regulation of survival gene product expression|positive regulation of transcription initiation from RNA polymerase II promoter|positive regulation of transcription via serum response element binding|regulation of cardiac muscle contraction|right ventricular cardiac muscle tissue morphogenesis|septum secundum development|spleen development|thyroid gland development|vasculogenesis|ventricular septum morphogenesis		chromatin binding|protein heterodimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|serum response element binding|transcription factor binding			central_nervous_system(1)	1	Renal(175;0.000159)|Lung NSC(126;0.00229)|all_lung(126;0.004)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000183)			TTCAAGTCCCCGACGCCGAAG	0.667	Esophageal Squamous(72;810 1219 2387 13420 44943)		NA											11	37					3.07112e-06	3.46216e-06	0.010729	1	0
HRH2	3274	broad.mit.edu	37	5	175111256	175111256	+	Silent	SNP	G	G	C			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr5:175111256G>C	uc003mdd.2	+	1	2793	c.1020G>C	c.(1018-1020)CTG>CTC	p.L340L	HRH2_uc003mdc.3_Silent_p.L340L	NM_022304	NP_071640	P25021	HRH2_HUMAN	histamine receptor H2 isoform 2	340	Cytoplasmic (Potential).				G-protein signaling, coupled to cyclic nucleotide second messenger|immune response	integral to plasma membrane	histamine receptor activity			ovary(1)	1	all_cancers(89;0.00805)|Renal(175;0.000269)|Lung NSC(126;0.00419)|all_lung(126;0.00711)	Medulloblastoma(196;0.0208)|all_neural(177;0.0277)|all_hematologic(541;0.214)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000183)	Colorectal(1;0.0154)|COAD - Colon adenocarcinoma(1;0.149)	Betazole(DB00272)|Cimetidine(DB00501)|Doxepin(DB01142)|Epinastine(DB00751)|Famotidine(DB00927)|Histamine Phosphate(DB00667)|Nizatidine(DB00585)|Ranitidine(DB00863)	AGAAACCCCTGAAGCTCCAGG	0.592			NA											9	106					0	0	0.006214	0	0
GPRIN1	114787	broad.mit.edu	37	5	176025235	176025235	+	Missense_Mutation	SNP	T	T	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr5:176025235T>A	uc003meo.1	-	2	1776	c.1601A>T	c.(1600-1602)AAG>ATG	p.K534M		NM_052899	NP_443131	Q7Z2K8	GRIN1_HUMAN	G protein-regulated inducer of neurite outgrowth	534						growth cone|plasma membrane				ovary(2)	2	all_cancers(89;0.00263)|Renal(175;0.000269)|Lung NSC(126;0.00902)|all_lung(126;0.0142)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			GGGAGCCGCCTTTCCAGAGGC	0.662			NA											27	60					0	0	0.010818	0	0
CLK4	57396	broad.mit.edu	37	5	178040602	178040602	+	Missense_Mutation	SNP	C	C	G			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr5:178040602C>G	uc003mjf.1	-	7	806	c.698G>C	c.(697-699)GGT>GCT	p.G233A	CLK4_uc003mjg.1_Missense_Mutation_p.G197A|CLK4_uc010jku.1_Missense_Mutation_p.G53A|CLK4_uc003mjh.1_Missense_Mutation_p.G53A|CLK4_uc010jkv.1_RNA|CLK4_uc011dgg.1_Missense_Mutation_p.G233A|CLK4_uc011dgh.1_Missense_Mutation_p.G53A	NM_020666	NP_065717	Q9HAZ1	CLK4_HUMAN	CDC-like kinase 4	233	Protein kinase.					nucleus	ATP binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(1)	1	all_cancers(89;0.000969)|Renal(175;0.000159)|all_epithelial(37;0.000451)|Lung NSC(126;0.00545)|all_lung(126;0.00918)	all_cancers(40;0.0272)|all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.235)		ACAAACATGACCATGATGATC	0.348			NA											10	35					0	0	0.006214	0	0
ZFP2	80108	broad.mit.edu	37	5	178358866	178358866	+	Silent	SNP	A	A	G			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr5:178358866A>G	uc003mjn.1	+	5	1061	c.552A>G	c.(550-552)AAA>AAG	p.K184K	ZFP2_uc010jky.2_Silent_p.K184K|ZFP2_uc010jkx.1_Silent_p.K184K	NM_030613	NP_085116	Q6ZN57	ZFP2_HUMAN	zinc finger protein 2 homolog	184					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|pancreas(1)|skin(1)	3	all_cancers(89;0.000639)|all_epithelial(37;0.000109)|Renal(175;0.000159)|Lung NSC(126;0.00199)|all_lung(126;0.00351)	all_neural(177;0.00802)|Medulloblastoma(196;0.0145)|all_hematologic(541;0.248)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.00655)|GBM - Glioblastoma multiforme(465;0.0302)|OV - Ovarian serous cystadenocarcinoma(192;0.0615)|Epithelial(171;0.111)		CCGGAGAGAAACCCTATCAGT	0.398			NA											3	25					0	0	0.000602	0	0
ZNF354C	30832	broad.mit.edu	37	5	178506897	178506897	+	Missense_Mutation	SNP	G	G	C			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr5:178506897G>C	uc003mju.2	+	5	1579	c.1464G>C	c.(1462-1464)AGG>AGC	p.R488S		NM_014594	NP_055409	Q86Y25	Z354C_HUMAN	zinc finger protein 354C	488	C2H2-type 10.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1	all_cancers(89;0.00065)|all_epithelial(37;0.000153)|Renal(175;0.000159)|Lung NSC(126;0.00175)|all_lung(126;0.00309)	all_cancers(40;0.19)|all_neural(177;0.00802)|Medulloblastoma(196;0.0145)|all_hematologic(541;0.248)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.247)		AACATGAGAGGATCCACACTG	0.393			NA											9	26					0	0	0.004482	0	0
HNRNPH1	3187	broad.mit.edu	37	5	179044535	179044535	+	Nonsense_Mutation	SNP	G	G	C			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr5:179044535G>C	uc003mkf.3	-	9	1143	c.1037C>G	c.(1036-1038)TCA>TGA	p.S346*	HNRNPH1_uc011dgn.1_Nonsense_Mutation_p.S76*|HNRNPH1_uc003mkg.3_Nonsense_Mutation_p.S254*|HNRNPH1_uc003mke.3_Nonsense_Mutation_p.S346*|HNRNPH1_uc003mkh.3_Nonsense_Mutation_p.S346*	NM_005520	NP_005511	P31943	HNRH1_HUMAN	heterogeneous nuclear ribonucleoprotein H1	346	RRM 3.|2 X 16 AA Gly-rich approximate repeats.				regulation of RNA splicing	actin cytoskeleton|catalytic step 2 spliceosome|cytoplasm|heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	nucleotide binding|poly(U) RNA binding|protein binding				0						TTTGTCTTTTGACATAGCTGC	0.408			NA											5	74					0	0	0.001168	0	0
OR2Y1	134083	broad.mit.edu	37	5	180166157	180166157	+	Missense_Mutation	SNP	C	C	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr5:180166157C>A	uc003mmf.1	-	1	902	c.902G>T	c.(901-903)TGG>TTG	p.W301L		NM_001001657	NP_001001657	Q8NGV0	OR2Y1_HUMAN	olfactory receptor, family 2, subfamily Y,	301	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1	all_cancers(89;1.25e-05)|all_epithelial(37;4.36e-06)|Renal(175;0.000159)|Lung NSC(126;0.00317)|all_lung(126;0.0041)|Breast(19;0.114)	all_cancers(40;0.0834)|Medulloblastoma(196;0.0392)|all_neural(177;0.0529)|all_hematologic(541;0.191)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			TAGTACTTTCCACAGAGCCCC	0.418			NA											18	89					1.33834e-09	1.62889e-09	0.007413	1	0
OR2V2	285659	broad.mit.edu	37	5	180581966	180581966	+	Silent	SNP	C	C	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr5:180581966C>A	uc011dhj.1	+	1	24	c.24C>A	c.(22-24)TCC>TCA	p.S8S		NM_206880	NP_996763	Q96R30	OR2V2_HUMAN	olfactory receptor, family 2, subfamily V,	8	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|central_nervous_system(1)	2	all_cancers(89;8.26e-06)|all_epithelial(37;1.02e-06)|Renal(175;0.000159)|Lung NSC(126;0.00354)|all_lung(126;0.00609)|Breast(19;0.0684)	all_cancers(40;0.0103)|Medulloblastoma(196;0.0392)|all_neural(177;0.0529)|all_hematologic(541;0.0652)|all_lung(500;0.149)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			TGAACCAGTCCTACACAGATG	0.507			NA											22	62					1.55469e-16	2.06157e-16	0.00333	1	0
OR2V2	285659	broad.mit.edu	37	5	180582444	180582444	+	Missense_Mutation	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr5:180582444C>T	uc011dhj.1	+	1	502	c.502C>T	c.(502-504)CCC>TCC	p.P168S		NM_206880	NP_996763	Q96R30	OR2V2_HUMAN	olfactory receptor, family 2, subfamily V,	168	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|central_nervous_system(1)	2	all_cancers(89;8.26e-06)|all_epithelial(37;1.02e-06)|Renal(175;0.000159)|Lung NSC(126;0.00354)|all_lung(126;0.00609)|Breast(19;0.0684)	all_cancers(40;0.0103)|Medulloblastoma(196;0.0392)|all_neural(177;0.0529)|all_hematologic(541;0.0652)|all_lung(500;0.149)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			AATGAATTTCCCCTACTGTGG	0.473			NA											29	143					0	0	0.007291	0	0
OR2V2	285659	broad.mit.edu	37	5	180582654	180582654	+	Missense_Mutation	SNP	G	G	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr5:180582654G>T	uc011dhj.1	+	1	712	c.712G>T	c.(712-714)GCC>TCC	p.A238S		NM_206880	NP_996763	Q96R30	OR2V2_HUMAN	olfactory receptor, family 2, subfamily V,	238	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|central_nervous_system(1)	2	all_cancers(89;8.26e-06)|all_epithelial(37;1.02e-06)|Renal(175;0.000159)|Lung NSC(126;0.00354)|all_lung(126;0.00609)|Breast(19;0.0684)	all_cancers(40;0.0103)|Medulloblastoma(196;0.0392)|all_neural(177;0.0529)|all_hematologic(541;0.0652)|all_lung(500;0.149)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CTGGAAAAAGGCCCTGGCCAC	0.572			NA											16	62					1.37285e-15	1.80234e-15	0.004007	1	0
HUS1B	135458	broad.mit.edu	37	6	656540	656540	+	Silent	SNP	C	C	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr6:656540C>A	uc003mtg.2	-	1	425	c.405G>T	c.(403-405)CGG>CGT	p.R135R	EXOC2_uc003mtd.2_Intron|EXOC2_uc003mte.2_Intron|EXOC2_uc011dho.1_Intron	NM_148959	NP_683762	Q8NHY5	HUS1B_HUMAN	HUS1 checkpoint protein B	135											0	Ovarian(93;0.0733)	Breast(5;0.00139)|all_lung(73;0.0691)|all_hematologic(90;0.0895)		OV - Ovarian serous cystadenocarcinoma(45;0.041)|BRCA - Breast invasive adenocarcinoma(62;0.0965)		TGGGAAGCACCCGCACGGGCA	0.731			NA											52	29					1.74971e-23	2.39677e-23	0.01441	1	0
GMDS	2762	broad.mit.edu	37	6	1930451	1930451	+	Silent	SNP	A	A	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr6:1930451A>T	uc003mtq.2	-	7	847	c.657T>A	c.(655-657)GTT>GTA	p.V219V		NM_001500	NP_001491	O60547	GMDS_HUMAN	GDP-mannose 4,6-dehydratase	219					'de novo' GDP-L-fucose biosynthetic process|GDP-mannose metabolic process|leukocyte cell-cell adhesion		coenzyme binding|GDP-mannose 4,6-dehydratase activity			central_nervous_system(1)	1	Ovarian(93;0.0733)	all_cancers(2;7.64e-19)|all_epithelial(2;3.05e-16)|Colorectal(2;0.00414)|all_hematologic(90;0.00997)|all_lung(73;0.0141)|Lung NSC(90;0.0802)		Epithelial(2;7.61e-06)|all cancers(2;0.000111)|STAD - Stomach adenocarcinoma(2;0.000231)|Colorectal(2;0.00445)|COAD - Colon adenocarcinoma(2;0.0125)|OV - Ovarian serous cystadenocarcinoma(45;0.0563)		TTTTTCGAGTAACGAAATTAG	0.433			NA											33	18					0	0	0.010818	0	0
CDYL	9425	broad.mit.edu	37	6	4892412	4892412	+	Nonsense_Mutation	SNP	G	G	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr6:4892412G>T	uc003mwi.2	+	4	783	c.652G>T	c.(652-654)GAG>TAG	p.E218*	CDYL_uc003mwj.2_Nonsense_Mutation_p.E164*|CDYL_uc003mwk.2_Intron|CDYL_uc011dhx.1_Nonsense_Mutation_p.E32*|CDYL_uc011dhy.1_Nonsense_Mutation_p.E32*	NM_001143971	NP_001137443	Q9Y232	CDYL1_HUMAN	chromodomain protein, Y chromosome-like isoform	218					regulation of transcription, DNA-dependent|spermatogenesis|transcription, DNA-dependent	nucleus	histone acetyltransferase activity				0	Ovarian(93;0.11)	all_hematologic(90;0.0901)|Lung NSC(90;0.244)		OV - Ovarian serous cystadenocarcinoma(45;0.182)		CGAGAGCCCTGAGAAACTGGA	0.597			NA											16	23					2.31682e-05	2.54658e-05	0.003163	1	0
NEDD9	4739	broad.mit.edu	37	6	11185641	11185641	+	Silent	SNP	T	T	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr6:11185641T>A	uc003mzv.2	-	7	2426	c.2259A>T	c.(2257-2259)GCA>GCT	p.A753A	NEDD9_uc010joz.2_Silent_p.A753A|NEDD9_uc003mzw.3_Silent_p.A607A	NM_006403	NP_006394	Q14511	CASL_HUMAN	neural precursor cell expressed, developmentally	753	Divergent helix-loop-helix motif.				actin filament bundle assembly|cell adhesion|cell division|integrin-mediated signaling pathway|mitosis|regulation of growth	cell cortex|focal adhesion|Golgi apparatus|lamellipodium|nucleus	protein binding				0	Breast(50;0.0768)|Ovarian(93;0.152)	all_hematologic(90;0.135)	Epithelial(50;0.0647)|all cancers(50;0.179)			CCAGTTTGTGTGCACTGAGGA	0.547			NA											60	57					0	0	0.01441	0	0
CD83	9308	broad.mit.edu	37	6	14131775	14131775	+	Missense_Mutation	SNP	A	A	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr6:14131775A>T	uc003nbi.2	+	3	356	c.178A>T	c.(178-180)ATG>TTG	p.M60L	CD83_uc003nbh.2_Missense_Mutation_p.M60L	NM_004233	NP_004224	Q01151	CD83_HUMAN	CD83 antigen isoform a	60	Extracellular (Potential).|Ig-like V-type.				defense response|humoral immune response|signal transduction	integral to plasma membrane					0	Breast(50;0.00245)|Ovarian(93;0.137)	all_hematologic(90;0.117)				TGAAGAGAGGATGGAGACACC	0.507			NA											22	20					0	0	0.012319	0	0
MYLIP	29116	broad.mit.edu	37	6	16143378	16143378	+	Nonsense_Mutation	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr6:16143378C>T	uc003nbq.2	+	4	829	c.592C>T	c.(592-594)CAG>TAG	p.Q198*	MYLIP_uc003nbr.2_Nonsense_Mutation_p.Q17*	NM_013262	NP_037394	Q8WY64	MYLIP_HUMAN	myosin regulatory light chain interacting	198	FERM.				cellular component movement|nervous system development	cytoplasm|cytoskeleton|extrinsic to membrane	cytoskeletal protein binding|ubiquitin-protein ligase activity|zinc ion binding			pancreas(1)	1	Breast(50;0.0799)|Ovarian(93;0.103)	all_hematologic(90;0.0895)	Epithelial(50;0.241)			TAGCGAAGGGCAGAAACTGCT	0.443			NA											6	56					0	0	0.001984	0	0
HIST1H2BI	8346	broad.mit.edu	37	6	26273408	26273408	+	Missense_Mutation	SNP	G	G	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr6:26273408G>A	uc003nhk.2	+	1	205	c.205G>A	c.(205-207)GAC>AAC	p.D69N	HIST1H3G_uc003nhi.2_5'Flank	NM_003525	NP_003516	P62807	H2B1C_HUMAN	histone cluster 1, H2bi	69					defense response to bacterium|nucleosome assembly	nucleosome|nucleus	DNA binding|protein binding				0						CTTCGTCAACGACATTTTCGA	0.567			NA											38	170					0	0	0.003755	0	0
HMGN4	10473	broad.mit.edu	37	6	26545530	26545530	+	Silent	SNP	A	A	G			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr6:26545530A>G	uc003nig.2	+	2	334	c.96A>G	c.(94-96)CCA>CCG	p.P32P		NM_006353	NP_006344	O00479	HMGN4_HUMAN	high mobility group nucleosomal binding domain	32						chromatin|nucleus	DNA binding				0						CTGCTAAACCAGCTCCTCCAA	0.502			NA											21	26					0	0	0.008871	0	0
ZNF184	7738	broad.mit.edu	37	6	27420806	27420806	+	Missense_Mutation	SNP	G	G	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr6:27420806G>A	uc003njj.2	-	5	1343	c.532C>T	c.(532-534)CCT>TCT	p.P178S	ZNF184_uc010jqv.2_Missense_Mutation_p.P178S|ZNF184_uc003nji.2_Missense_Mutation_p.P178S	NM_007149	NP_009080	Q99676	ZN184_HUMAN	zinc finger protein 184	178					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						TTATTTACAGGGCCTTTTTCC	0.403			NA											58	66					0	0	0.01441	0	0
HIST1H3H	8357	broad.mit.edu	37	6	27777984	27777984	+	Missense_Mutation	SNP	G	G	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr6:27777984G>A	uc003njm.2	+	1	143	c.133G>A	c.(133-135)GGT>AGT	p.G45S	HIST1H2BL_uc003njl.2_5'Flank	NM_003536	NP_003527	P68431	H31_HUMAN	histone cluster 1, H3h	45					blood coagulation|nucleosome assembly|regulation of gene silencing|S phase	nucleoplasm|nucleosome	DNA binding|protein binding			ovary(1)	1						CTATCGGCCTGGTACAGTGGC	0.652			NA											4	57					0	0	0.000602	0	0
ZNF165	7718	broad.mit.edu	37	6	28056879	28056879	+	Silent	SNP	G	G	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr6:28056879G>A	uc003nkg.2	+	5	2173	c.1089G>A	c.(1087-1089)CAG>CAA	p.Q363Q	ZNF165_uc003nkh.2_Silent_p.Q363Q|ZNF165_uc003nki.3_Silent_p.Q363Q|ZSCAN12P1_uc003nkj.3_5'Flank	NM_003447	NP_003438	P49910	ZN165_HUMAN	zinc finger protein 165	363	C2H2-type 2.				viral reproduction	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0						CTAGGCATCAGAGAATCCACA	0.433			NA											6	23					0	0	0.001984	0	0
ZNF311	282890	broad.mit.edu	37	6	28963357	28963357	+	Silent	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr6:28963357C>T	uc003nlu.2	-	7	1935	c.1422G>A	c.(1420-1422)GAG>GAA	p.E474E	ZNF311_uc011dlk.1_Silent_p.E382E|ZNF311_uc003nlv.2_Silent_p.E382E	NM_001010877	NP_001010877	Q5JNZ3	ZN311_HUMAN	zinc finger protein 311	474	C2H2-type 9.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding				0						TCCCACACTCCTCACACCTGT	0.493			NA											28	33					0	0	0.00632	0	0
C2	717	broad.mit.edu	37	6	31901508	31901508	+	Silent	SNP	G	G	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr6:31901508G>A	uc003nyf.2	+	4	828	c.564G>A	c.(562-564)GAG>GAA	p.E188E	C2_uc003nyc.2_Missense_Mutation_p.S20N|C2_uc011doo.1_Missense_Mutation_p.S20N|C2_uc011dop.1_Silent_p.E65E|C2_uc003nye.3_Silent_p.E188E|C2_uc010jtk.2_Silent_p.E56E|C2_uc011doq.1_Silent_p.E159E|C2_uc003nyg.2_Silent_p.E56E|CFB_uc011dor.1_Silent_p.E126E	NM_000063	NP_000054	P06681	CO2_HUMAN	complement component 2 isoform 1 preproprotein	188	Sushi 3.				complement activation, classical pathway|innate immune response|proteolysis	extracellular space	serine-type endopeptidase activity			ovary(1)|skin(1)	2		Ovarian(999;0.00965)		LUAD - Lung adenocarcinoma(999;0.247)		GGTCTTCGGAGCGGGAGTGCC	0.647			NA											45	44					0	0	0.013114	0	0
SKIV2L	6499	broad.mit.edu	37	6	31927146	31927146	+	Missense_Mutation	SNP	T	T	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr6:31927146T>A	uc003nyn.1	+	2	484	c.95T>A	c.(94-96)CTG>CAG	p.L32Q	RDBP_uc003nyk.2_5'Flank|RDBP_uc011dot.1_5'Flank|RDBP_uc003nyl.1_5'Flank|RDBP_uc003nym.1_5'Flank|MIR1236_hsa-mir-1236|MI0006326_5'Flank|SKIV2L_uc011dou.1_5'UTR|SKIV2L_uc011dov.1_5'UTR	NM_006929	NP_008860	Q15477	SKIV2_HUMAN	superkiller viralicidic activity 2-like homolog	32						nucleus	ATP binding|ATP-dependent RNA helicase activity|protein binding|RNA binding			ovary(1)|large_intestine(1)|breast(1)|central_nervous_system(1)	4						CACTGGGAGCTGCTGAACTTG	0.587			NA											173	168					0	0	0.01441	0	0
TNXB	7148	broad.mit.edu	37	6	32017941	32017941	+	Silent	SNP	C	C	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr6:32017941C>A	uc003nzl.2	-	27	9469	c.9267G>T	c.(9265-9267)CTG>CTT	p.L3089L		NM_019105	NP_061978	P22105	TENX_HUMAN	tenascin XB isoform 1 precursor	3136	Fibronectin type-III 23.				actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding				0						TGTACTGGACCAGGAAGTGGT	0.642			NA											35	62					3.62531e-18	4.84264e-18	0.004289	1	0
TNXB	7148	broad.mit.edu	37	6	32037579	32037579	+	Missense_Mutation	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr6:32037579C>T	uc003nzl.2	-	15	5540	c.5338G>A	c.(5338-5340)GAG>AAG	p.E1780K		NM_019105	NP_061978	P22105	TENX_HUMAN	tenascin XB isoform 1 precursor	1862	Fibronectin type-III 11.				actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding				0						TGCAGCTCCTCCCCCAGACGG	0.577			NA											9	24					0	0	0.006214	0	0
TAP2	6891	broad.mit.edu	37	6	32805830	32805830	+	Missense_Mutation	SNP	A	A	C			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr6:32805830A>C	uc003occ.2	-	1	212	c.181T>G	c.(181-183)TTT>GTT	p.F61V	TAP2_uc011dqf.1_Missense_Mutation_p.F61V|TAP2_uc003ocb.1_Missense_Mutation_p.F61V|TAP2_uc003ocd.2_Missense_Mutation_p.F61V	NM_018833	NP_061313	Q03519	TAP2_HUMAN	transporter 2, ATP-binding cassette, sub-family	61	Helical; Name=2; (Potential).				antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent|antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent|antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent|cytosol to ER transport|intracellular transport of viral proteins in host cell|peptide antigen transport|positive regulation of antigen processing and presentation of peptide antigen via MHC class I|positive regulation of T cell mediated cytotoxicity	nucleus|plasma membrane|TAP complex	ATP binding|MHC class I protein binding|oligopeptide-transporting ATPase activity|peptide antigen binding|peptide antigen-transporting ATPase activity|TAP1 binding|TAP2 binding|tapasin binding				0						GTCCCCACAAATCCCAGCAGC	0.667			NA											17	91					0	0	0.004007	0	0
TAPBP	6892	broad.mit.edu	37	6	33272866	33272866	+	Silent	SNP	G	G	A	rs145473025		TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr6:33272866G>A	uc003odx.1	-	4	939	c.768C>T	c.(766-768)TTC>TTT	p.F256F	TAPBP_uc010jus.1_Silent_p.F274F|TAPBP_uc003ody.2_Silent_p.F256F|TAPBP_uc003odz.2_Silent_p.F256F|TAPBP_uc010jut.1_Silent_p.F169F|TAPBP_uc011drc.1_Silent_p.F256F	NM_003190	NP_003181	O15533	TPSN_HUMAN	tapasin isoform 1 precursor	256	Lumenal (Potential).				antigen processing and presentation of endogenous peptide antigen via MHC class I|immune response|peptide antigen stabilization|protein complex assembly|retrograde vesicle-mediated transport, Golgi to ER	Golgi membrane|MHC class I peptide loading complex|microsome	MHC class I protein binding|peptide antigen binding|peptide antigen-transporting ATPase activity|TAP1 binding|TAP2 binding|unfolded protein binding			ovary(1)	1						TAGGCAGCCAGAAGGTCCCAT	0.582			NA											24	114					0	0	0.005443	0	0
NUDT3	11165	broad.mit.edu	37	6	34263448	34263448	+	Silent	SNP	C	C	G			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr6:34263448C>G	uc003ojl.2	-	3	527	c.225G>C	c.(223-225)GGG>GGC	p.G75G		NM_006703	NP_006694	O95989	NUDT3_HUMAN	nudix-type motif 3	75	Nudix hydrolase.			G->A: Loss of function.	cell-cell signaling|diadenosine polyphosphate catabolic process|diphosphoinositol polyphosphate catabolic process	cytoplasm	diphosphoinositol-polyphosphate diphosphatase activity|magnesium ion binding				0						TTCCCAATGTCCCTTTTACTC	0.308	GBM(96;1206 1939 18658 39482)		NA											8	28					0	0	0.004482	0	0
SLC26A8	116369	broad.mit.edu	37	6	35927260	35927260	+	Missense_Mutation	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr6:35927260C>T	uc003olm.2	-	16	1951	c.1840G>A	c.(1840-1842)GAT>AAT	p.D614N	SLC26A8_uc010jwa.2_RNA|SLC26A8_uc003olk.2_Missense_Mutation_p.D196N|SLC26A8_uc003oln.2_Missense_Mutation_p.D614N|SLC26A8_uc003oll.2_Missense_Mutation_p.D509N	NM_052961	NP_443193	Q96RN1	S26A8_HUMAN	solute carrier family 26, member 8 isoform a	614	STAS.|Cytoplasmic (Potential).				cell differentiation|meiosis|multicellular organismal development|spermatogenesis	integral to membrane|plasma membrane	anion:anion antiporter activity|chloride channel activity|oxalate transmembrane transporter activity|protein binding|sulfate transmembrane transporter activity			ovary(2)	2						TCCAGATCATCACAGTTGCAG	0.363			NA											13	62					0	0	0.001855	0	0
GLO1	2739	broad.mit.edu	37	6	38670747	38670747	+	Missense_Mutation	SNP	C	C	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr6:38670747C>A	uc003ooc.2	-	1	206	c.84G>T	c.(82-84)AAG>AAT	p.K28N		NM_006708	NP_006699	Q04760	LGUL_HUMAN	glyoxalase I	28					anti-apoptosis|carbohydrate metabolic process	cytoplasm	lactoylglutathione lyase activity|metal ion binding			ovary(1)	1					Glutathione(DB00143)	CTGTGCCCACCTTGGTACTGG	0.721			NA											15	16					2.61681e-11	3.27271e-11	0.00245	1	0
TSPO2	222642	broad.mit.edu	37	6	41010795	41010795	+	Missense_Mutation	SNP	G	G	A	rs148297848	byFrequency	TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr6:41010795G>A	uc003opj.2	+	2	372	c.71G>A	c.(70-72)CGT>CAT	p.R24H	UNC5CL_uc010jxe.1_Intron|TSPO2_uc003opk.2_Missense_Mutation_p.V34M|TSPO2_uc011dub.1_Missense_Mutation_p.R24H	NM_001010873	NP_001010873	Q5TGU0	TSPO2_HUMAN	benzodiazapine receptor (peripheral)-like 1	24					transport	endoplasmic reticulum membrane|integral to membrane	cholesterol binding|receptor activity				0						CTGTTCACTCGTGATCACATG	0.552			NA											68	73					0	0	0.01441	0	0
KIAA0240	23506	broad.mit.edu	37	6	42796998	42796998	+	Silent	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr6:42796998C>T	uc003osn.1	+	6	1078	c.927C>T	c.(925-927)GTC>GTT	p.V309V	KIAA0240_uc003osm.1_Silent_p.V309V|KIAA0240_uc011duw.1_Silent_p.V309V|KIAA0240_uc003oso.1_Silent_p.V309V|KIAA0240_uc003osp.1_Silent_p.V309V	NM_015349	NP_056164	Q6AI39	K0240_HUMAN	hypothetical protein LOC23506	309										ovary(1)	1	Colorectal(47;0.196)		Colorectal(64;0.00237)|COAD - Colon adenocarcinoma(64;0.00473)|all cancers(41;0.00524)|KIRC - Kidney renal clear cell carcinoma(15;0.02)|Kidney(15;0.0388)|OV - Ovarian serous cystadenocarcinoma(102;0.104)			CAAATAAAGTCCCAATTAATA	0.388			NA											17	132					0	0	0.00499	0	0
PEX6	5190	broad.mit.edu	37	6	42934376	42934376	+	Missense_Mutation	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr6:42934376C>T	uc003otf.2	-	10	2074	c.1981G>A	c.(1981-1983)GAG>AAG	p.E661K	PEX6_uc010jya.2_RNA	NM_000287	NP_000278	Q13608	PEX6_HUMAN	peroxisomal biogenesis factor 6	661					protein import into peroxisome matrix, translocation|protein stabilization	cytosol|peroxisomal membrane	ATP binding|ATPase activity, coupled|protein C-terminus binding|protein complex binding			ovary(1)	1			all cancers(41;0.00235)|Colorectal(64;0.00237)|COAD - Colon adenocarcinoma(64;0.00473)|KIRC - Kidney renal clear cell carcinoma(15;0.02)|Kidney(15;0.0388)|OV - Ovarian serous cystadenocarcinoma(102;0.0562)			TCATCCTCCTCAGTCAAGCCA	0.597			NA											8	192					0	0	0.006214	0	0
CAPN11	11131	broad.mit.edu	37	6	44144038	44144038	+	Missense_Mutation	SNP	T	T	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr6:44144038T>A	uc003owt.1	+	9	1002	c.964T>A	c.(964-966)TGG>AGG	p.W322R	CAPN11_uc011dvn.1_5'Flank	NM_007058	NP_008989	Q9UMQ6	CAN11_HUMAN	calpain 11	322	Calpain catalytic.				proteolysis	acrosomal vesicle	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity			ovary(1)|breast(1)	2	all_cancers(18;3.19e-06)|Lung NSC(15;0.00108)|all_lung(25;0.00278)|Hepatocellular(11;0.00908)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)			CCGGAATCCCTGGGGCCGGAT	0.597			NA											29	30					0	0	0.012213	0	0
GPR115	221393	broad.mit.edu	37	6	47684541	47684541	+	Splice_Site	SNP	G	G	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr6:47684541G>T	uc003oza.1	+	7	2191	c.1933_splice	c.e7-1	p.G645_splice	GPR115_uc003oyz.1_Splice_Site_p.G702_splice|GPR115_uc003ozb.1_Splice_Site_p.G643_splice	NM_153838	NP_722580	Q8IZF3	GP115_HUMAN	G-protein coupled receptor 115 precursor						neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(3)|skin(3)|upper_aerodigestive_tract(1)|breast(1)	8						TTTTGCCACAGGGTTTTTTCA	0.393	GBM(22;431 510 9010 26644 32828)		NA											20	23					2.37509e-13	3.0465e-13	0.010504	1	0
PGK2	5232	broad.mit.edu	37	6	49754596	49754596	+	Missense_Mutation	SNP	G	G	C			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr6:49754596G>C	uc003ozu.2	-	1	412	c.305C>G	c.(304-306)GCA>GGA	p.A102G		NM_138733	NP_620061	P07205	PGK2_HUMAN	phosphoglycerate kinase 2	102					glycolysis	cytosol	ATP binding|phosphoglycerate kinase activity	p.A102S(1)		ovary(1)	1	Lung NSC(77;0.0402)					CTCCACTTCTGCGCCTACACA	0.532			NA											41	38					0	0	0.006999	0	0
DST	667	broad.mit.edu	37	6	56401663	56401663	+	Missense_Mutation	SNP	G	G	C			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr6:56401663G>C	uc003pdf.2	-	56	10355	c.10327C>G	c.(10327-10329)CAG>GAG	p.Q3443E	DST_uc003pcz.3_Missense_Mutation_p.Q3265E|DST_uc011dxj.1_Missense_Mutation_p.Q3294E|DST_uc011dxk.1_Missense_Mutation_p.Q3305E|DST_uc003pcy.3_Missense_Mutation_p.Q2939E	NM_001144769	NP_001138241	Q03001	DYST_HUMAN	dystonin isoform 2	5351	Spectrin 7.				cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			ovary(7)|central_nervous_system(6)|upper_aerodigestive_tract(1)	14	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			GCAGCACTCTGAATAAGGCCT	0.423			NA											7	51					0	0	0.00308	0	0
BAI3	577	broad.mit.edu	37	6	69640530	69640530	+	Silent	SNP	A	A	G			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr6:69640530A>G	uc003pev.3	+	4	1285	c.837A>G	c.(835-837)CAA>CAG	p.Q279Q	BAI3_uc010kak.2_Silent_p.Q279Q	NM_001704	NP_001695	O60242	BAI3_HUMAN	brain-specific angiogenesis inhibitor 3	279	Extracellular (Potential).				negative regulation of angiogenesis|neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			lung(27)|ovary(8)|skin(6)|pancreas(4)|central_nervous_system(3)|urinary_tract(1)|breast(1)	50		all_lung(197;0.212)				CTCAGGAACAAGCTGATGCTG	0.333			NA											3	9					0	0	0.004672	0	0
BAI3	577	broad.mit.edu	37	6	69758130	69758130	+	Missense_Mutation	SNP	C	C	G			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr6:69758130C>G	uc003pev.3	+	14	2609	c.2161C>G	c.(2161-2163)CCA>GCA	p.P721A	BAI3_uc010kak.2_Missense_Mutation_p.P721A	NM_001704	NP_001695	O60242	BAI3_HUMAN	brain-specific angiogenesis inhibitor 3	721	Extracellular (Potential).				negative regulation of angiogenesis|neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			lung(27)|ovary(8)|skin(6)|pancreas(4)|central_nervous_system(3)|urinary_tract(1)|breast(1)	50		all_lung(197;0.212)				CATCAACTTTCCAATGAAAGG	0.363			NA											15	6					0	0	0.004007	0	0
COL9A1	1297	broad.mit.edu	37	6	71004033	71004033	+	Missense_Mutation	SNP	G	G	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr6:71004033G>A	uc003pfg.3	-	5	692	c.533C>T	c.(532-534)TCC>TTC	p.S178F		NM_001851	NP_001842	P20849	CO9A1_HUMAN	alpha 1 type IX collagen isoform 1 precursor	178	Nonhelical region (NC4).|TSP N-terminal.				axon guidance|cell adhesion|organ morphogenesis	collagen type IX	metal ion binding			ovary(4)	4						ATGCCACTGGGAATCAAACAA	0.423			NA											21	70					0	0	0.010504	0	0
RNGTT	8732	broad.mit.edu	37	6	89638909	89638909	+	Missense_Mutation	SNP	G	G	C			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr6:89638909G>C	uc003pmr.2	-	3	472	c.252C>G	c.(250-252)ATC>ATG	p.I84M	RNGTT_uc003pms.2_Missense_Mutation_p.I84M|RNGTT_uc011dzu.1_Missense_Mutation_p.I24M|RNGTT_uc003pmt.2_Missense_Mutation_p.I84M	NM_003800	NP_003791	O60942	MCE1_HUMAN	RNA guanylyltransferase and 5'-phosphatase	84	TPase.				interspecies interaction between organisms|mRNA capping|transcription from RNA polymerase II promoter|viral reproduction	nucleoplasm	GTP binding|mRNA guanylyltransferase activity|polynucleotide 5'-phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			upper_aerodigestive_tract(1)	1		all_cancers(76;4.07e-09)|Prostate(29;1.16e-10)|Acute lymphoblastic leukemia(125;1.49e-10)|all_hematologic(105;7.79e-07)|all_epithelial(107;6.86e-05)		BRCA - Breast invasive adenocarcinoma(108;0.151)		TTATATATTTGATTCCTTCTT	0.269			NA											4	14					0	0	0.000602	0	0
GABRR1	2569	broad.mit.edu	37	6	89890150	89890150	+	Missense_Mutation	SNP	G	G	C			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr6:89890150G>C	uc003pna.2	-	9	1462	c.1007C>G	c.(1006-1008)CCG>CGG	p.P336R	GABRR1_uc011dzv.1_Missense_Mutation_p.P313R	NM_002042	NP_002033	P24046	GBRR1_HUMAN	gamma-aminobutyric acid (GABA) receptor, rho 1	336					gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			pancreas(1)	1		all_cancers(76;9.49e-09)|Prostate(29;1.16e-10)|Acute lymphoblastic leukemia(125;1.46e-10)|all_hematologic(105;7.74e-07)|all_epithelial(107;0.000114)		BRCA - Breast invasive adenocarcinoma(108;0.00917)	Picrotoxin(DB00466)	GGAGACGCGCGGCATGGAGGC	0.507			NA											28	43					0	0	0.012213	0	0
UBE2J1	51465	broad.mit.edu	37	6	90039433	90039433	+	Silent	SNP	G	G	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr6:90039433G>A	uc010kcb.2	-	9	1095	c.922C>T	c.(922-924)CTG>TTG	p.L308L	UBE2J1_uc003pnc.2_Silent_p.L308L	NM_016021	NP_057105	Q9Y385	UB2J1_HUMAN	ubiquitin-conjugating enzyme E2, J1	308	Lumenal (Potential).					endoplasmic reticulum membrane|integral to membrane	ATP binding|ubiquitin-protein ligase activity				0		all_cancers(76;1.65e-09)|Prostate(29;1.16e-10)|Acute lymphoblastic leukemia(125;1.45e-10)|all_hematologic(105;7.74e-07)|all_epithelial(107;2.5e-05)|Lung NSC(302;0.238)		BRCA - Breast invasive adenocarcinoma(108;0.0139)		TCGTTTGCCAGATATATTCGT	0.403			NA											19	17					0	0	0.008871	0	0
BACH2	60468	broad.mit.edu	37	6	90642323	90642323	+	Missense_Mutation	SNP	G	G	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr6:90642323G>T	uc011eab.1	-	9	3139	c.2330C>A	c.(2329-2331)CCC>CAC	p.P777H	BACH2_uc003pnw.2_Missense_Mutation_p.P777H	NM_021813	NP_068585	Q9BYV9	BACH2_HUMAN	BTB and CNC homology 1, basic leucine zipper	777						nucleus	protein dimerization activity|sequence-specific DNA binding			ovary(3)|pancreas(1)|lung(1)|skin(1)	6		all_cancers(76;7.37e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.0063)		BRCA - Breast invasive adenocarcinoma(108;0.0799)		GGGGGGTCCGGGGGGAGCCGC	0.632			NA											54	47					2.31418e-15	3.03266e-15	0.01441	1	0
EPHA7	2045	broad.mit.edu	37	6	94068026	94068026	+	Missense_Mutation	SNP	A	A	C			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr6:94068026A>C	uc003poe.2	-	4	1177	c.936T>G	c.(934-936)TGT>TGG	p.C312W	EPHA7_uc003pof.2_Missense_Mutation_p.C312W|EPHA7_uc011eac.1_Missense_Mutation_p.C312W	NM_004440	NP_004431	Q15375	EPHA7_HUMAN	ephrin receptor EphA7 precursor	312	Extracellular (Potential).|Cys-rich.					integral to plasma membrane	ATP binding|ephrin receptor activity			lung(8)|ovary(7)|upper_aerodigestive_tract(3)|central_nervous_system(3)|skin(3)|large_intestine(2)|stomach(1)|pancreas(1)	28		all_cancers(76;7.47e-10)|Acute lymphoblastic leukemia(125;1.88e-09)|all_hematologic(75;1.75e-07)|all_epithelial(107;3.6e-05)|Lung NSC(302;0.0368)|all_lung(197;0.0509)|Colorectal(196;0.142)		BRCA - Breast invasive adenocarcinoma(108;0.0847)		ACCCATCTTCACATTCACATC	0.458			NA											4	21					0	0	0.009096	0	0
KIAA0776	23376	broad.mit.edu	37	6	96997630	96997631	+	Missense_Mutation	DNP	GG	GG	TT			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr6:96997630_96997631GG>TT	uc003por.2	+	15	1821_1822	c.1773_1774GG>TT	c.(1771-1776)TCGGAT>TCTTAT	p.D592Y	KIAA0776_uc010kck.2_RNA	NM_015323	NP_056138	O94874	UFL1_HUMAN	hypothetical protein LOC23376	592					negative regulation of NF-kappaB transcription factor activity|negative regulation of protein ubiquitination|protein ufmylation	endoplasmic reticulum|nucleus	protein binding|UFM1 conjugating enzyme activity			ovary(1)	1		all_cancers(76;5.83e-05)|Acute lymphoblastic leukemia(125;7.02e-10)|all_hematologic(75;1.23e-06)|all_epithelial(107;0.0604)|Colorectal(196;0.0721)		BRCA - Breast invasive adenocarcinoma(108;0.0934)		TCTTAGCTTCGGATTTAATGAT	0.396			NA											11	20					0	0	0.004672	0	0
CCNC	892	broad.mit.edu	37	6	99997442	99997442	+	Silent	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr6:99997442C>T	uc003pqe.2	-	9	827	c.540G>A	c.(538-540)GTG>GTA	p.V180V	uc003pqc.2_Intron|CCNC_uc003pqd.2_Silent_p.V95V|CCNC_uc010kcr.2_RNA|CCNC_uc010kcs.2_Silent_p.V179V|CCNC_uc011eah.1_Silent_p.V95V	NM_005190	NP_005181	P24863	CCNC_HUMAN	cyclin C isoform a	180					regulation of cyclin-dependent protein kinase activity|regulation of transcription, DNA-dependent|transcription, DNA-dependent	DNA-directed RNA polymerase II, holoenzyme	protein kinase binding				0		all_cancers(76;8.46e-06)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(107;0.0128)|Colorectal(196;0.069)|Lung NSC(302;0.186)		BRCA - Breast invasive adenocarcinoma(108;0.064)		AGGTATCATTCACTATCCTCC	0.363	GBM(57;273 1020 40094 44454 49348)		NA											4	7					0	0	0.009096	0	0
NR2E1	7101	broad.mit.edu	37	6	108502082	108502082	+	Missense_Mutation	SNP	G	G	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr6:108502082G>T	uc003psg.2	+	7	1566	c.811G>T	c.(811-813)GTG>TTG	p.V271L		NM_003269	NP_003260	Q9Y466	NR2E1_HUMAN	nuclear receptor subfamily 2, group E, member 1	271	Ligand-binding (By similarity).				regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	sequence-specific DNA binding|steroid hormone receptor activity|zinc ion binding			central_nervous_system(1)|skin(1)	2		all_cancers(87;8.13e-05)|Acute lymphoblastic leukemia(125;3.07e-08)|all_hematologic(75;3.33e-06)|all_epithelial(87;0.00866)|Colorectal(196;0.0637)		BRCA - Breast invasive adenocarcinoma(108;0.013)|Epithelial(106;0.0521)|all cancers(137;0.068)|OV - Ovarian serous cystadenocarcinoma(136;0.0689)		TTTACAAGAGGTGGTGGCTCG	0.423			NA											37	46					4.62619e-21	6.26023e-21	0.004289	1	0
FIG4	9896	broad.mit.edu	37	6	110098260	110098260	+	Missense_Mutation	SNP	G	G	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr6:110098260G>A	uc003ptt.2	+	16	2101	c.1886G>A	c.(1885-1887)AGA>AAA	p.R629K	FIG4_uc011eau.1_Missense_Mutation_p.R352K	NM_014845	NP_055660	Q92562	FIG4_HUMAN	Sac domain-containing inositol phosphatase 3	629					cell death	endosome membrane	protein binding			ovary(1)	1		all_cancers(87;8.63e-07)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;0.000124)|all_lung(197;0.0187)|Colorectal(196;0.0492)|Lung SC(18;0.0548)		OV - Ovarian serous cystadenocarcinoma(136;0.0355)|Epithelial(106;0.038)|all cancers(137;0.0425)|BRCA - Breast invasive adenocarcinoma(108;0.079)		CCAACAAGAAGAAGGTATTTT	0.353			NA											6	15					0	0	0.001168	0	0
RSPH4A	345895	broad.mit.edu	37	6	116949479	116949479	+	Silent	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr6:116949479C>T	uc003pxe.2	+	3	1754	c.1609C>T	c.(1609-1611)CTA>TTA	p.L537L	RSPH4A_uc010kee.2_Silent_p.L537L	NM_001010892	NP_001010892	Q5TD94	RSH4A_HUMAN	radial spoke head 4 homolog A isoform 1	537	Glu-rich.				cilium axoneme assembly|cilium movement	cytoplasm|cytoskeleton|radial spoke					0						AGTGATTGATCTAGTAGAATC	0.428			NA							Kartagener_syndrome				13	53					0	0	0.00245	0	0
NKAIN2	154215	broad.mit.edu	37	6	124676442	124676442	+	Silent	SNP	G	G	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr6:124676442G>T	uc003pzo.2	+	3	499	c.222G>T	c.(220-222)ACG>ACT	p.T74T	NKAIN2_uc003pzn.1_Silent_p.T74T|NKAIN2_uc003pzp.2_Silent_p.T73T|NKAIN2_uc010keq.2_Silent_p.T74T|NKAIN2_uc010ker.2_5'UTR	NM_001040214	NP_001035304	Q5VXU1	NKAI2_HUMAN	T-cell lymphoma breakpoint-associated target 1	74	Helical; (Potential).					integral to membrane|plasma membrane					0				GBM - Glioblastoma multiforme(226;0.104)		TCTGGGTTACGTGGAATGTGT	0.388			NA											31	41					3.86903e-22	5.27496e-22	0.013726	1	0
C6orf174	387104	broad.mit.edu	37	6	127796797	127796797	+	Missense_Mutation	SNP	G	G	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr6:127796797G>A	uc003qbd.2	-	6	3239	c.2374C>T	c.(2374-2376)CTC>TTC	p.L792F	C6orf174_uc003qbc.2_5'UTR	NM_001012279	NP_001012279	Q5TF21	CF174_HUMAN	hypothetical protein LOC387104 precursor	792						integral to membrane				breast(3)|ovary(2)|skin(1)	6				GBM - Glioblastoma multiforme(226;0.026)|all cancers(137;0.161)		GTGGGCGTGAGGCAGCGGATG	0.697			NA											43	36					0	0	0.00874	0	0
LAMA2	3908	broad.mit.edu	37	6	129649547	129649547	+	Missense_Mutation	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr6:129649547C>T	uc003qbn.2	+	29	4406	c.4301C>T	c.(4300-4302)TCG>TTG	p.S1434L	LAMA2_uc003qbo.2_Missense_Mutation_p.S1434L	NM_000426	NP_000417	P24043	LAMA2_HUMAN	laminin alpha 2 subunit isoform a precursor	1434	Laminin EGF-like 15.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|breast(1)|skin(1)	10				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		CCTGAAACATCGATATGCCAG	0.537			NA											43	58					0	0	0.011902	0	0
TMEM200A	114801	broad.mit.edu	37	6	130762590	130762590	+	Silent	SNP	C	C	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr6:130762590C>A	uc003qca.2	+	3	1894	c.1023C>A	c.(1021-1023)GTC>GTA	p.V341V	TMEM200A_uc010kfh.2_Silent_p.V341V|TMEM200A_uc010kfi.2_Silent_p.V341V|TMEM200A_uc003qcb.2_Silent_p.V341V	NM_052913	NP_443145	Q86VY9	T200A_HUMAN	transmembrane protein 200A	341	Cytoplasmic (Potential).					integral to membrane				ovary(1)	1				GBM - Glioblastoma multiforme(226;0.0139)|OV - Ovarian serous cystadenocarcinoma(155;0.12)		TCCAGCCCGTCAGCACAGTGC	0.498			NA											6	41					5.9392e-07	6.8551e-07	0.001168	1	0
TMEM200A	114801	broad.mit.edu	37	6	130762655	130762655	+	Missense_Mutation	SNP	T	T	C			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr6:130762655T>C	uc003qca.2	+	3	1959	c.1088T>C	c.(1087-1089)ATG>ACG	p.M363T	TMEM200A_uc010kfh.2_Missense_Mutation_p.M363T|TMEM200A_uc010kfi.2_Missense_Mutation_p.M363T|TMEM200A_uc003qcb.2_Missense_Mutation_p.M363T	NM_052913	NP_443145	Q86VY9	T200A_HUMAN	transmembrane protein 200A	363	Cytoplasmic (Potential).					integral to membrane				ovary(1)	1				GBM - Glioblastoma multiforme(226;0.0139)|OV - Ovarian serous cystadenocarcinoma(155;0.12)		AAGTCATCTATGGCTCTCGGA	0.527			NA											8	35					0	0	0.00308	0	0
PDE7B	27115	broad.mit.edu	37	6	136512860	136512860	+	Missense_Mutation	SNP	A	A	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr6:136512860A>T	uc003qgp.2	+	13	1538	c.1235A>T	c.(1234-1236)CAG>CTG	p.Q412L	uc003qgq.1_Intron|PDE7B_uc003qgr.2_Missense_Mutation_p.Q464L	NM_018945	NP_061818	Q9NP56	PDE7B_HUMAN	phosphodiesterase 7B	412					signal transduction|synaptic transmission	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding			ovary(1)	1	Colorectal(23;0.24)			OV - Ovarian serous cystadenocarcinoma(155;0.0136)|GBM - Glioblastoma multiforme(68;0.0147)	Dyphylline(DB00651)|Ketotifen(DB00920)	AACAAGGCCCAGTGGAAGAGC	0.637			NA											7	13					0	0	0.00308	0	0
BCLAF1	9774	broad.mit.edu	37	6	136594296	136594296	+	Silent	SNP	G	G	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr6:136594296G>A	uc003qgx.1	-	7	2135	c.1882C>T	c.(1882-1884)CTA>TTA	p.L628L	BCLAF1_uc003qgw.1_Silent_p.L455L|BCLAF1_uc003qgy.1_Silent_p.L626L|BCLAF1_uc011edc.1_RNA|BCLAF1_uc011edd.1_RNA|BCLAF1_uc011ede.1_Silent_p.L626L	NM_014739	NP_055554	Q9NYF8	BCLF1_HUMAN	BCL2-associated transcription factor 1 isoform	628					induction of apoptosis|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding			ovary(1)	1	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00226)|OV - Ovarian serous cystadenocarcinoma(155;0.00331)		CGCTCGTTTAGGGTCATTGCA	0.408	Colon(142;1534 1789 5427 7063 28491)		NA											3	87					0	0	0.009096	0	0
SHPRH	257218	broad.mit.edu	37	6	146256096	146256096	+	Missense_Mutation	SNP	C	C	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr6:146256096C>A	uc003qlf.2	-	13	3336	c.2937G>T	c.(2935-2937)CAG>CAT	p.Q979H	SHPRH_uc003qld.2_Missense_Mutation_p.Q979H|SHPRH_uc003qle.2_Missense_Mutation_p.Q979H|SHPRH_uc003qlg.1_Missense_Mutation_p.Q535H|SHPRH_uc003qlj.1_Missense_Mutation_p.Q868H|SHPRH_uc003qlh.2_5'Flank	NM_001042683	NP_001036148	Q149N8	SHPRH_HUMAN	SNF2 histone linker PHD RING helicase isoform a	979					DNA repair|nucleosome assembly	nucleosome|nucleus	ATP binding|DNA binding|helicase activity|ligase activity|zinc ion binding			ovary(1)|kidney(1)|central_nervous_system(1)	3		Ovarian(120;0.0365)		OV - Ovarian serous cystadenocarcinoma(155;1.47e-07)|GBM - Glioblastoma multiforme(68;0.0124)		GACAGCAGGCCTGTCTGAGCC	0.443			NA											20	20					1.56452e-12	1.98922e-12	0.007413	1	0
SASH1	23328	broad.mit.edu	37	6	148846478	148846478	+	Missense_Mutation	SNP	G	G	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr6:148846478G>T	uc003qme.1	+	11	1736	c.1261G>T	c.(1261-1263)GGC>TGC	p.G421C	SASH1_uc011eeb.1_Missense_Mutation_p.G182C|SASH1_uc003qmf.1_5'UTR	NM_015278	NP_056093	O94885	SASH1_HUMAN	SAM and SH3 domain containing 1	421							protein binding			central_nervous_system(1)	1		Ovarian(120;0.0169)		OV - Ovarian serous cystadenocarcinoma(155;5.63e-11)|GBM - Glioblastoma multiforme(68;0.0701)		TCTGCACGTTGGCAGTAATAA	0.423			NA											46	61					1.5774e-09	1.91824e-09	0.01441	1	0
C6orf211	79624	broad.mit.edu	37	6	151789697	151789697	+	Missense_Mutation	SNP	G	G	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr6:151789697G>T	uc003qok.1	+	5	1037	c.778G>T	c.(778-780)GTT>TTT	p.V260F	C6orf211_uc011ees.1_Missense_Mutation_p.V141F	NM_024573	NP_078849	Q9H993	CF211_HUMAN	hypothetical protein LOC79624	260							protein binding				0			BRCA - Breast invasive adenocarcinoma(37;0.183)	OV - Ovarian serous cystadenocarcinoma(155;5.27e-11)		ATTTGAGCTTGTTACAGATTT	0.358			NA											50	43					2.29192e-23	3.13358e-23	0.01441	1	0
TIAM2	26230	broad.mit.edu	37	6	155500537	155500537	+	Missense_Mutation	SNP	C	C	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr6:155500537C>A	uc003qqb.2	+	14	3927	c.2654C>A	c.(2653-2655)CCA>CAA	p.P885Q	TIAM2_uc003qqe.2_Missense_Mutation_p.P885Q|TIAM2_uc010kjj.2_Missense_Mutation_p.P418Q|TIAM2_uc003qqf.2_Missense_Mutation_p.P261Q|TIAM2_uc011efl.1_Missense_Mutation_p.P221Q|TIAM2_uc003qqg.2_Missense_Mutation_p.P197Q	NM_012454	NP_036586	Q8IVF5	TIAM2_HUMAN	T-cell lymphoma invasion and metastasis 2	885					apoptosis|cellular lipid metabolic process|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|filopodium|growth cone|lamellipodium	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			ovary(3)|breast(1)	4		Ovarian(120;0.196)		OV - Ovarian serous cystadenocarcinoma(155;8.1e-13)|BRCA - Breast invasive adenocarcinoma(81;0.0053)		GAAGTCTTTCCACTAAATGTT	0.373			NA											26	34					8.24728e-16	1.0847e-15	0.004656	1	0
SNX9	51429	broad.mit.edu	37	6	158342655	158342655	+	Nonsense_Mutation	SNP	G	G	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr6:158342655G>T	uc003qqv.1	+	10	1215	c.1042G>T	c.(1042-1044)GAA>TAA	p.E348*		NM_016224	NP_057308	Q9Y5X1	SNX9_HUMAN	sorting nexin 9	348	PX.				cell communication|intracellular protein transport|lipid tube assembly|positive regulation of GTPase activity|positive regulation of protein oligomerization|receptor-mediated endocytosis	clathrin-coated vesicle|cytoplasmic vesicle membrane|extrinsic to internal side of plasma membrane|ruffle|trans-Golgi network	1-phosphatidylinositol binding|protein homodimerization activity|ubiquitin protein ligase binding				0		Breast(66;0.000776)|Ovarian(120;0.0303)|Prostate(117;0.167)		OV - Ovarian serous cystadenocarcinoma(65;8.06e-18)|BRCA - Breast invasive adenocarcinoma(81;4.48e-05)		CTCAGAAAGTGAAGTTTTCCA	0.438			NA											8	16					0.00621372	0.00639427	0.006214	1	0
IGF2R	3482	broad.mit.edu	37	6	160510217	160510217	+	Missense_Mutation	SNP	G	G	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr6:160510217G>T	uc003qta.2	+	43	6547	c.6399G>T	c.(6397-6399)CAG>CAT	p.Q2133H		NM_000876	NP_000867	P11717	MPRI_HUMAN	insulin-like growth factor 2 receptor precursor	2133	14.|Lumenal (Potential).				receptor-mediated endocytosis	cell surface|endocytic vesicle|endosome|integral to plasma membrane|lysosomal membrane|trans-Golgi network transport vesicle	glycoprotein binding|insulin-like growth factor receptor activity|phosphoprotein binding|transporter activity			ovary(3)	3		Breast(66;0.000777)|Ovarian(120;0.0305)		OV - Ovarian serous cystadenocarcinoma(65;2.45e-17)|BRCA - Breast invasive adenocarcinoma(81;1.09e-05)		AGGAGGTGCAGATGGTGAATG	0.502			NA											19	29					3.32936e-07	3.86121e-07	0.006122	1	0
THBS2	7058	broad.mit.edu	37	6	169632775	169632775	+	Missense_Mutation	SNP	G	G	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr6:169632775G>T	uc003qwt.2	-	13	2164	c.1916C>A	c.(1915-1917)GCC>GAC	p.A639D		NM_003247	NP_003238	P35442	TSP2_HUMAN	thrombospondin 2 precursor	639	EGF-like 2; calcium-binding (Potential).				cell adhesion	extracellular region	calcium ion binding|heparin binding|protein binding|structural molecule activity			ovary(5)	5		Breast(66;1.78e-05)|Ovarian(120;0.0728)|Esophageal squamous(34;0.247)		OV - Ovarian serous cystadenocarcinoma(33;1.85e-21)|BRCA - Breast invasive adenocarcinoma(81;1.43e-06)|GBM - Glioblastoma multiforme(31;0.000379)		TTCCGTCTTGGCTGCTTCCAG	0.597	Esophageal Squamous(91;219 1934 18562 44706)		NA											44	57					1.89013e-27	2.62126e-27	0.01441	1	0
TBP	6908	broad.mit.edu	37	6	170871103	170871103	+	Silent	SNP	G	G	A	rs149441883		TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr6:170871103G>A	uc003qxt.2	+	3	511	c.279G>A	c.(277-279)CAG>CAA	p.Q93Q	TBP_uc003qxu.2_Silent_p.Q93Q|TBP_uc011ehf.1_Silent_p.Q73Q|TBP_uc011ehg.1_Silent_p.Q93Q	NM_003194	NP_003185	P20226	TBP_HUMAN	TATA box binding protein	93	Poly-Gln.		Missing.		cell death|interspecies interaction between organisms|transcription elongation from RNA polymerase II promoter|transcription from RNA polymerase III promoter|viral reproduction	transcription factor TFIIA complex|transcription factor TFIID complex	repressing transcription factor binding|transcription regulatory region DNA binding			ovary(1)	1		Breast(66;5.08e-05)|Ovarian(120;0.125)|Esophageal squamous(34;0.246)		OV - Ovarian serous cystadenocarcinoma(33;1.07e-22)|BRCA - Breast invasive adenocarcinoma(81;5.01e-06)|GBM - Glioblastoma multiforme(31;0.00591)		agcagcagcagcaacaggcag	0.229			NA											4	45					0	0	0.000602	0	0
INTS1	26173	broad.mit.edu	37	7	1519959	1519959	+	Silent	SNP	G	G	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr7:1519959G>A	uc003skn.2	-	30	4169	c.4068C>T	c.(4066-4068)TTC>TTT	p.F1356F		NM_001080453	NP_001073922	Q8N201	INT1_HUMAN	integrator complex subunit 1	1356					snRNA processing	integral to membrane|integrator complex|nuclear membrane					0		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0181)|OV - Ovarian serous cystadenocarcinoma(56;6.99e-15)		CTACCTGGAGGAACATGCCAG	0.662			NA											5	18					0	0	0.000602	0	0
INTS1	26173	broad.mit.edu	37	7	1523686	1523686	+	Missense_Mutation	SNP	C	C	G			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr7:1523686C>G	uc003skn.2	-	25	3483	c.3382G>C	c.(3382-3384)GTG>CTG	p.V1128L	INTS1_uc003skp.1_Missense_Mutation_p.V475L	NM_001080453	NP_001073922	Q8N201	INT1_HUMAN	integrator complex subunit 1	1128					snRNA processing	integral to membrane|integrator complex|nuclear membrane					0		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0181)|OV - Ovarian serous cystadenocarcinoma(56;6.99e-15)		ATGCGCCTCACGTAGCGTGAG	0.662			NA											21	44					0	0	0.012319	0	0
TTYH3	80727	broad.mit.edu	37	7	2686509	2686509	+	Missense_Mutation	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr7:2686509C>T	uc003smp.2	+	2	333	c.146C>T	c.(145-147)GCC>GTC	p.A49V	TTYH3_uc010ksn.2_5'Flank|TTYH3_uc003smq.2_5'Flank	NM_025250	NP_079526	Q9C0H2	TTYH3_HUMAN	tweety 3	49	Helical; Name=1; (Potential).					chloride channel complex|plasma membrane	chloride channel activity				0		Ovarian(82;0.0112)		OV - Ovarian serous cystadenocarcinoma(56;2.04e-14)		CTGGGGGCCGCCGCCCTGGCC	0.726			NA											5	15					0	0	0.001984	0	0
SDK1	221935	broad.mit.edu	37	7	4116637	4116637	+	Missense_Mutation	SNP	G	G	C			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr7:4116637G>C	uc003smx.2	+	21	3157	c.3018G>C	c.(3016-3018)CAG>CAC	p.Q1006H	SDK1_uc010kso.2_Missense_Mutation_p.Q282H	NM_152744	NP_689957	Q7Z5N4	SDK1_HUMAN	sidekick 1 precursor	1006	Fibronectin type-III 4.				cell adhesion	integral to membrane				large_intestine(3)|ovary(2)|skin(1)	6		all_cancers(1;0.127)|Ovarian(82;0.0177)|Myeloproliferative disorder(862;0.194)		UCEC - Uterine corpus endometrioid carcinoma (126;0.121)|OV - Ovarian serous cystadenocarcinoma(56;9.65e-15)		TAGGCTATCAGATCTCTTGGG	0.542			NA											9	32					0	0	0.004482	0	0
PHF14	9678	broad.mit.edu	37	7	11022767	11022767	+	Missense_Mutation	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr7:11022767C>T	uc003sry.1	+	3	1316	c.881C>T	c.(880-882)TCT>TTT	p.S294F	PHF14_uc011jxi.1_Intron|PHF14_uc003srz.2_Missense_Mutation_p.S294F|PHF14_uc011jxj.1_Intron	NM_014660	NP_055475	O94880	PHF14_HUMAN	PHD finger protein 14 isoform 2	294							zinc ion binding			kidney(2)|skin(1)	3				UCEC - Uterine corpus endometrioid carcinoma (126;0.205)		CTGACCCTATCTCAAAGCAAG	0.413			NA											3	15					0	0	0.009096	0	0
THSD7A	221981	broad.mit.edu	37	7	11485703	11485703	+	Nonsense_Mutation	SNP	T	T	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr7:11485703T>A	uc003ssf.3	-	13	3301	c.3049A>T	c.(3049-3051)AGA>TGA	p.R1017*		NM_015204	NP_056019	Q9UPZ6	THS7A_HUMAN	thrombospondin, type I, domain containing 7A	1017	TSP type-1 10.|Extracellular (Potential).					integral to membrane				ovary(3)	3				UCEC - Uterine corpus endometrioid carcinoma (126;0.163)		CTGTTACATCTAGATGTTTCC	0.428			NA								HNSCC(18;0.044)			28	73					0	0	0.007291	0	0
TWISTNB	221830	broad.mit.edu	37	7	19748388	19748388	+	Missense_Mutation	SNP	C	C	G			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr7:19748388C>G	uc003sup.1	-	1	273	c.252G>C	c.(250-252)GAG>GAC	p.E84D		NM_001002926	NP_001002926	Q3B726	RPA43_HUMAN	TWIST neighbor	84						microtubule cytoskeleton|nucleolus	DNA-directed RNA polymerase activity			ovary(1)	1						ATCGGTACCTCTCAGAATAGC	0.562			NA									OREG0017879	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	11	50					0	0	0.008291	0	0
DNAH11	8701	broad.mit.edu	37	7	21723442	21723442	+	Missense_Mutation	SNP	G	G	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr7:21723442G>A	uc003svc.2	+	33	5553	c.5522G>A	c.(5521-5523)CGT>CAT	p.R1841H		NM_003777	NP_003768	Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	1841	Stem (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(8)|large_intestine(3)|pancreas(3)|central_nervous_system(1)	15						TCTCAACTTCGTCACCGATGG	0.443			NA							Kartagener_syndrome				13	148					0	0	0.003163	0	0
CDCA7L	55536	broad.mit.edu	37	7	21947917	21947917	+	Missense_Mutation	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr7:21947917C>T	uc010kuk.2	-	4	632	c.512G>A	c.(511-513)CGC>CAC	p.R171H	CDCA7L_uc003sve.3_Missense_Mutation_p.R137H|CDCA7L_uc010kul.2_Missense_Mutation_p.R125H|CDCA7L_uc003svf.3_Missense_Mutation_p.R170H|CDCA7L_uc011jyk.1_Missense_Mutation_p.R171H	NM_018719	NP_061189	Q96GN5	CDA7L_HUMAN	cell division cycle associated 7-like isoform 1	171					positive regulation of cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus					0						ATTCTGTAAGCGTGCGCTAGA	0.428			NA											20	36					0	0	0.008871	0	0
OSBPL3	26031	broad.mit.edu	37	7	24911677	24911677	+	Missense_Mutation	SNP	T	T	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr7:24911677T>A	uc003sxf.2	-	3	513	c.108A>T	c.(106-108)GAA>GAT	p.E36D	OSBPL3_uc003sxd.2_RNA|OSBPL3_uc003sxe.2_RNA|OSBPL3_uc003sxg.2_Missense_Mutation_p.E36D|OSBPL3_uc003sxh.2_Missense_Mutation_p.E36D|OSBPL3_uc003sxi.2_Missense_Mutation_p.E36D	NM_015550	NP_056365	Q9H4L5	OSBL3_HUMAN	oxysterol-binding protein-like protein 3 isoform	36					lipid transport		lipid binding|protein binding			skin(1)	1						CTTCCACCACTTCCCAGCTGT	0.413			NA											20	31					0	0	0.008871	0	0
HOXA1	3198	broad.mit.edu	37	7	27135155	27135155	+	Missense_Mutation	SNP	C	C	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr7:27135155C>A	uc003sye.2	-	1	471	c.377G>T	c.(376-378)TGC>TTC	p.C126F	HOXA1_uc003syd.2_Intron|uc003syg.2_5'Flank	NM_005522	NP_005513	P49639	HXA1_HUMAN	homeobox A1 isoform a	126						nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(3)	3						AGCGGGAGCGCACTGGGGGTA	0.567			NA											19	83					5.35267e-07	6.18796e-07	0.007413	1	0
HOXA4	3201	broad.mit.edu	37	7	27169157	27169157	+	Missense_Mutation	SNP	C	C	A	rs145032542	byFrequency	TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr7:27169157C>A	uc003sym.3	-	2	697	c.650G>T	c.(649-651)CGC>CTC	p.R217L	HOXA3_uc003syk.2_5'Flank	NM_002141	NP_002132	Q00056	HXA4_HUMAN	homeobox A4	217	Homeobox.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)	1						GGTTCGAGAGCGCTTAGGCTC	0.458			NA											16	57					0.006122	0.00630884	0.006122	1	0
CREB5	9586	broad.mit.edu	37	7	28848855	28848855	+	Nonsense_Mutation	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr7:28848855C>T	uc003szq.2	+	9	1468	c.1078C>T	c.(1078-1080)CAG>TAG	p.Q360*	CREB5_uc003szo.2_Nonsense_Mutation_p.Q327*|CREB5_uc003szr.2_Nonsense_Mutation_p.Q353*|CREB5_uc003szs.2_Nonsense_Mutation_p.Q221*	NM_182898	NP_878901	Q02930	CREB5_HUMAN	cAMP responsive element binding protein 5	360					positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter		protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(2)	2						ACAGCCACCCCAGCCCACAGG	0.637			NA											10	96					0	0	0.008291	0	0
GARS	2617	broad.mit.edu	37	7	30649288	30649288	+	Missense_Mutation	SNP	C	C	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr7:30649288C>A	uc003tbm.2	+	7	1180	c.823C>A	c.(823-825)CCA>ACA	p.P275T		NM_002047	NP_002038	P41250	SYG_HUMAN	glycyl-tRNA synthetase	275					cell death|diadenosine tetraphosphate biosynthetic process|glycyl-tRNA aminoacylation	cytosol|mitochondrial matrix|soluble fraction	ATP binding|glycine-tRNA ligase activity|protein dimerization activity			ovary(1)	1					Glycine(DB00145)	TCTATCCCCTCCAGTGTCTTT	0.358			NA											14	27					0.000151284	0.000163198	0.001855	1	0
INMT	11185	broad.mit.edu	37	7	30793439	30793439	+	Missense_Mutation	SNP	C	C	G			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr7:30793439C>G	uc003tbs.1	+	2	263	c.247C>G	c.(247-249)CTC>GTC	p.L83V	FAM188B_uc010kwe.2_5'UTR|INMT_uc010kwc.1_RNA|INMT_uc010kwd.1_Missense_Mutation_p.L82V	NM_006774	NP_006765	O95050	INMT_HUMAN	indolethylamine N-methyltransferase	83						cytoplasm	amine N-methyltransferase activity				0						AGACATCACTCTCTCCGACTT	0.567			NA											89	250					0	0	0.01441	0	0
GHRHR	2692	broad.mit.edu	37	7	31011704	31011704	+	Silent	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr7:31011704C>T	uc003tbx.2	+	6	639	c.591C>T	c.(589-591)TTC>TTT	p.F197F	GHRHR_uc003tbw.1_Silent_p.F197F|GHRHR_uc003tby.2_Silent_p.F133F|GHRHR_uc003tbz.2_Missense_Mutation_p.S15F	NM_000823	NP_000814	Q02643	GHRHR_HUMAN	growth hormone releasing hormone receptor	197	Extracellular (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|positive regulation of cAMP biosynthetic process|positive regulation of cell proliferation|positive regulation of growth hormone secretion|positive regulation of insulin-like growth factor receptor signaling pathway|positive regulation of multicellular organism growth|response to estrogen stimulus|response to glucocorticoid stimulus	cell surface|integral to membrane|nuclear inner membrane|nuclear matrix|nuclear outer membrane|plasma membrane|stored secretory granule	growth factor binding|growth hormone-releasing hormone receptor activity|peptide hormone binding			ovary(2)|lung(1)|breast(1)|large_intestine(1)	5					Sermorelin(DB00010)	ACTGCAGCTTCTCCACTGTAA	0.582			NA											10	30					0	0	0.010729	0	0
NEUROD6	63974	broad.mit.edu	37	7	31378209	31378209	+	Missense_Mutation	SNP	A	A	G			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr7:31378209A>G	uc003tch.2	-	2	1027	c.674T>C	c.(673-675)CTT>CCT	p.L225P		NM_022728	NP_073565	Q96NK8	NDF6_HUMAN	neurogenic differentiation 6	225					cell differentiation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(2)	2						GGAATTATCAAGAGTCCCATG	0.527			NA											41	75					0	0	0.00874	0	0
PDE1C	5137	broad.mit.edu	37	7	31793152	31793152	+	Nonsense_Mutation	SNP	A	A	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr7:31793152A>T	uc003tcm.1	-	18	2445	c.1976T>A	c.(1975-1977)TTG>TAG	p.L659*	PDE1C_uc003tcn.1_Nonsense_Mutation_p.L659*|PDE1C_uc003tco.1_Nonsense_Mutation_p.L719*	NM_005020	NP_005011	Q14123	PDE1C_HUMAN	phosphodiesterase 1C	659					activation of phospholipase C activity|nerve growth factor receptor signaling pathway	cytosol	calmodulin binding|calmodulin-dependent cyclic-nucleotide phosphodiesterase activity|metal ion binding			skin(3)|central_nervous_system(1)	4			GBM - Glioblastoma multiforme(11;0.216)			AAAATGACGCAAAGGAGGCTT	0.483			NA											16	45					0	0	0.00499	0	0
PDE1C	5137	broad.mit.edu	37	7	31877577	31877577	+	Missense_Mutation	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr7:31877577C>T	uc003tcm.1	-	10	1458	c.989G>A	c.(988-990)CGA>CAA	p.R330Q	PDE1C_uc003tcn.1_Missense_Mutation_p.R330Q|PDE1C_uc003tco.1_Missense_Mutation_p.R390Q|PDE1C_uc003tcr.2_Missense_Mutation_p.R330Q|PDE1C_uc003tcs.2_Missense_Mutation_p.R330Q	NM_005020	NP_005011	Q14123	PDE1C_HUMAN	phosphodiesterase 1C	330	Catalytic (By similarity).				activation of phospholipase C activity|nerve growth factor receptor signaling pathway	cytosol	calmodulin binding|calmodulin-dependent cyclic-nucleotide phosphodiesterase activity|metal ion binding			skin(3)|central_nervous_system(1)	4			GBM - Glioblastoma multiforme(11;0.216)			TACCAAGGTTCGAAACTCCCT	0.388			NA											33	84					0	0	0.013726	0	0
LSM5	23658	broad.mit.edu	37	7	32529942	32529942	+	Silent	SNP	C	C	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr7:32529942C>A	uc003tct.2	-	1	82	c.36G>T	c.(34-36)CTG>CTT	p.L12L	LSM5_uc003tcu.2_RNA|LSM5_uc011kag.1_Intron|LSM5_uc011kah.1_Intron	NM_012322	NP_036454	Q9Y4Y9	LSM5_HUMAN	LSM5 homolog, U6 small nuclear RNA associated	12					exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|mRNA processing|RNA splicing	cytosol|nucleus|ribonucleoprotein complex	protein binding|RNA binding				0			GBM - Glioblastoma multiforme(11;0.152)			CTAAGGGCAGCAGCTGCGACG	0.617			NA											14	66					4.7546e-09	5.75307e-09	0.004007	1	0
NPSR1	387129	broad.mit.edu	37	7	34889224	34889224	+	Missense_Mutation	SNP	A	A	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr7:34889224A>T	uc003teg.1	+	9	1201	c.1073A>T	c.(1072-1074)GAG>GTG	p.E358V	AAA1_uc010kwq.1_Intron|AAA1_uc011kaq.1_Intron|NPSR1_uc003teh.1_Nonstop_Mutation_p.*391C|NPSR1_uc010kwt.1_Missense_Mutation_p.E205V|NPSR1_uc010kwu.1_Missense_Mutation_p.E148V|NPSR1_uc010kwv.1_Missense_Mutation_p.E292V|NPSR1_uc003tei.1_Intron|NPSR1_uc010kww.1_Intron|NPSR1_uc011kar.1_Intron	NM_207172	NP_997055	Q6W5P4	NPSR1_HUMAN	G protein-coupled receptor for asthma	358	Cytoplasmic (Potential).					cytoplasm|integral to membrane|plasma membrane	vasopressin receptor activity			skin(3)|pancreas(1)	4					Halothane(DB01159)	GAGAGAACTGAGAGGCATGAG	0.488			NA											26	68					0	0	0.00632	0	0
EEPD1	80820	broad.mit.edu	37	7	36194191	36194191	+	Silent	SNP	A	A	G			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr7:36194191A>G	uc003tfa.2	+	2	898	c.258A>G	c.(256-258)GTA>GTG	p.V86V		NM_030636	NP_085139	Q7L9B9	EEPD1_HUMAN	endonuclease/exonuclease/phosphatase family	86					DNA repair		DNA binding				0						TCAGTGGTGTAGGCGCCACCA	0.612			NA											23	68					0	0	0.00278	0	0
EEPD1	80820	broad.mit.edu	37	7	36336752	36336752	+	Missense_Mutation	SNP	T	T	C			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr7:36336752T>C	uc003tfa.2	+	7	2106	c.1466T>C	c.(1465-1467)CTG>CCG	p.L489P		NM_030636	NP_085139	Q7L9B9	EEPD1_HUMAN	endonuclease/exonuclease/phosphatase family	489					DNA repair		DNA binding				0						TCGAAGTCTCTGGACAACATC	0.463			NA											3	25					0	0	0.009096	0	0
CDK13	8621	broad.mit.edu	37	7	40134118	40134118	+	Missense_Mutation	SNP	G	G	C			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr7:40134118G>C	uc003thh.3	+	14	4360	c.4078G>C	c.(4078-4080)GCT>CCT	p.A1360P	CDK13_uc003thi.3_Missense_Mutation_p.A1300P|CDK13_uc003thj.2_Missense_Mutation_p.A411P|CDK13_uc003thk.2_Missense_Mutation_p.A293P	NM_003718	NP_003709	Q14004	CDK13_HUMAN	cell division cycle 2-like 5 isoform 1	1360					alternative nuclear mRNA splicing, via spliceosome|hemopoiesis|interspecies interaction between organisms|phosphorylation of RNA polymerase II C-terminal domain|positive regulation of cell proliferation|regulation of mitosis	nuclear cyclin-dependent protein kinase holoenzyme complex|nuclear speck	ATP binding|cyclin-dependent protein kinase activity|protein binding|RNA polymerase II carboxy-terminal domain kinase activity			lung(2)|skin(2)|ovary(1)	5						AAGCAGTTCTGCTCCACCACT	0.438			NA											32	81					0	0	0.008361	0	0
AEBP1	165	broad.mit.edu	37	7	44149840	44149840	+	Missense_Mutation	SNP	C	C	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr7:44149840C>A	uc003tkb.2	+	11	1600	c.1295C>A	c.(1294-1296)GCG>GAG	p.A432E	AEBP1_uc003tkc.3_5'Flank|AEBP1_uc003tkd.2_5'Flank	NM_001129	NP_001120	Q8IUX7	AEBP1_HUMAN	adipocyte enhancer binding protein 1 precursor	432	Required for DNA-binding and interaction with NFKBIA (By similarity).|F5/8 type C.|Interaction with MAPK1 and MAPK3 (By similarity).				cell adhesion|muscle organ development|proteolysis|skeletal system development	cytoplasm|extracellular space|nucleus	DNA binding|metallocarboxypeptidase activity|sequence-specific DNA binding transcription factor activity|zinc ion binding				0						TATGATGGTGCGTGGTGTGCC	0.632			NA											14	44					1.5842e-08	1.8979e-08	0.001855	1	0
GCK	2645	broad.mit.edu	37	7	44184835	44184835	+	Missense_Mutation	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr7:44184835C>T	uc003tkl.2	-	10	1768	c.1298G>A	c.(1297-1299)AGC>AAC	p.S433N	GCK_uc003tkh.1_Missense_Mutation_p.S106N|GCK_uc003tki.1_Missense_Mutation_p.S111N|GCK_uc003tkj.1_Missense_Mutation_p.S432N|GCK_uc003tkk.1_Missense_Mutation_p.S434N	NM_000162	NP_000153	P35557	HXK4_HUMAN	glucokinase isoform 1	433					cellular response to insulin stimulus|cellular response to leptin stimulus|detection of glucose|endocrine pancreas development|glucose homeostasis|glucose transport|glycolysis|negative regulation of gluconeogenesis|positive regulation of glycogen biosynthetic process|positive regulation of insulin secretion|regulation of glucose transport|regulation of glycolysis|transmembrane transport	cytosol|nucleoplasm	ATP binding|glucokinase activity|glucose binding|protein binding			skin(3)|lung(1)	4						GATCTCGCAGCTGGGCGTCAG	0.657			NA											10	22					0	0	0.006214	0	0
H2AFV	94239	broad.mit.edu	37	7	44875224	44875224	+	Missense_Mutation	SNP	G	G	C			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr7:44875224G>C	uc003tma.2	-	4	384	c.229C>G	c.(229-231)CTC>GTC	p.L77V	H2AFV_uc003tlz.2_Missense_Mutation_p.L77V|H2AFV_uc011kca.1_5'Flank|H2AFV_uc003tmb.2_Missense_Mutation_p.L39V|H2AFV_uc003tmc.2_Intron|H2AFV_uc003tmd.2_Missense_Mutation_p.L51V	NM_012412	NP_036544	Q71UI9	H2AV_HUMAN	H2A histone family, member V isoform 1	77					nucleosome assembly	nucleosome|nucleus	DNA binding				0						TTTACTTTGAGATCCTTAGAA	0.463			NA											8	37					0	0	0.004482	0	0
TNS3	64759	broad.mit.edu	37	7	47343137	47343137	+	Silent	SNP	G	G	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr7:47343137G>T	uc003tnv.2	-	22	3235	c.2868C>A	c.(2866-2868)CCC>CCA	p.P956P	TNS3_uc003tnw.2_Silent_p.P956P	NM_022748	NP_073585	Q68CZ2	TENS3_HUMAN	tensin 3	956						focal adhesion	protein binding			ovary(4)	4						GGGAAACCATGGGCTTGGGGC	0.607			NA											5	24					0.000602214	0.000636401	0.000602	1	0
PKD1L1	168507	broad.mit.edu	37	7	47882629	47882629	+	Silent	SNP	C	C	A	rs148252365		TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr7:47882629C>A	uc003tny.1	-	34	5376	c.5376G>T	c.(5374-5376)CTG>CTT	p.L1792L		NM_138295	NP_612152	Q8TDX9	PK1L1_HUMAN	polycystin-1L1	1792	Cytoplasmic (Potential).				cell-cell adhesion	integral to membrane				ovary(8)|upper_aerodigestive_tract(2)|breast(1)	11						GATGGCCCGGCAGGGAAGCTT	0.468			NA											24	58					1.74197e-06	1.98848e-06	0.00632	1	0
VWC2	375567	broad.mit.edu	37	7	49842403	49842403	+	Nonsense_Mutation	SNP	G	G	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr7:49842403G>T	uc003tot.1	+	3	1349	c.793G>T	c.(793-795)GAG>TAG	p.E265*		NM_198570	NP_940972	Q2TAL6	VWC2_HUMAN	von Willebrand factor C domain containing 2	265	VWFC 2.				negative regulation of BMP signaling pathway|positive regulation of neuron differentiation	basement membrane|extracellular space					0						CCCTGTGTACGAGCCTGATCA	0.577			NA											18	40					9.16793e-09	1.10106e-08	0.00499	1	0
COBL	23242	broad.mit.edu	37	7	51261234	51261234	+	Missense_Mutation	SNP	G	G	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr7:51261234G>T	uc003tpr.3	-	3	483	c.298C>A	c.(298-300)CCA>ACA	p.P100T	COBL_uc003tps.2_Missense_Mutation_p.P100T|COBL_uc011kcl.1_Missense_Mutation_p.P100T|COBL_uc010kzc.2_Missense_Mutation_p.P100T|COBL_uc003tpt.2_Missense_Mutation_p.P100T|COBL_uc003tpp.3_5'Flank|COBL_uc003tpq.3_Missense_Mutation_p.P16T	NM_015198	NP_056013	O75128	COBL_HUMAN	cordon-bleu homolog	100										skin(3)|ovary(2)	5	Glioma(55;0.08)					TGGTGGGATGGATTCAGGTGG	0.423	NSCLC(189;2119 2138 12223 30818 34679)		NA											10	20					1.58986e-06	1.81627e-06	0.008291	1	0
POM121L12	285877	broad.mit.edu	37	7	53103547	53103547	+	Silent	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr7:53103547C>T	uc003tpz.2	+	1	199	c.183C>T	c.(181-183)AGC>AGT	p.S61S		NM_182595	NP_872401	Q8N7R1	P1L12_HUMAN	POM121 membrane glycoprotein-like 12	61											0						TGACTCAGAGCCATATTCAGT	0.701			NA											27	57					0	0	0.003954	0	0
POM121L12	285877	broad.mit.edu	37	7	53103731	53103731	+	Missense_Mutation	SNP	G	G	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr7:53103731G>T	uc003tpz.2	+	1	383	c.367G>T	c.(367-369)GGG>TGG	p.G123W		NM_182595	NP_872401	Q8N7R1	P1L12_HUMAN	POM121 membrane glycoprotein-like 12	123											0						CATGAAAGGGGGGCTGTGTCG	0.701			NA											14	43					2.23348e-06	2.53163e-06	0.004007	1	0
EGFR	1956	broad.mit.edu	37	7	55259501	55259501	+	Silent	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr7:55259501C>T	uc003tqk.2	+	21	2805	c.2559C>T	c.(2557-2559)ATC>ATT	p.I853I	EGFR_uc010kzg.1_Silent_p.I808I|EGFR_uc011kco.1_Silent_p.I800I|uc003tqo.2_5'Flank	NM_005228	NP_005219	P00533	EGFR_HUMAN	epidermal growth factor receptor isoform a	853	Cytoplasmic (Potential).|Protein kinase.				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.I853T(1)|p.I853I(1)		lung(9213)|central_nervous_system(103)|stomach(41)|upper_aerodigestive_tract(39)|prostate(32)|ovary(31)|thyroid(24)|breast(11)|peritoneum(9)|oesophagus(9)|salivary_gland(9)|large_intestine(8)|kidney(8)|urinary_tract(6)|skin(5)|adrenal_gland(5)|soft_tissue(4)|bone(3)|NS(2)|pancreas(2)|haematopoietic_and_lymphoid_tissue(2)|thymus(2)|liver(2)|eye(1)	9571	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	ATGTCAAGATCACAGATTTTG	0.532			8	A|O|Mis		glioma|NSCLC	NSCLC			Lung_Cancer_Familial_Clustering_of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			8	72					0	0	0.00308	0	0
ZNF713	349075	broad.mit.edu	37	7	55990964	55990965	+	Missense_Mutation	DNP	GG	GG	CC			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr7:55990964_55990965GG>CC	uc003trc.1	+	2	196_197	c.158_159GG>CC	c.(157-159)AGG>ACC	p.R53T	ZNF713_uc003tra.1_Missense_Mutation_p.R66T|MRPS17_uc003trb.2_Missense_Mutation_p.R53T	NM_182633	NP_872439	Q8N859	ZN713_HUMAN	zinc finger protein 713	53	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2	Breast(14;0.214)		Lung(13;0.00024)|LUSC - Lung squamous cell carcinoma(13;0.00099)			GAGAACTACAGGAATCTAGTTG	0.51			NA											23	56					0	0	0.004672	0	0
POM121	9883	broad.mit.edu	37	7	72409924	72409924	+	Missense_Mutation	SNP	G	G	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr7:72409924G>A	uc003twk.2	+	7	1417	c.1417G>A	c.(1417-1419)GAC>AAC	p.D473N	POM121_uc003twj.2_Missense_Mutation_p.D208N|POM121_uc010lam.1_Missense_Mutation_p.D208N	NM_172020	NP_742017	Q96HA1	P121A_HUMAN	nuclear pore membrane protein 121	473	Pore side (Potential).				carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	endoplasmic reticulum membrane|nuclear membrane|nuclear pore					0		Lung NSC(55;0.163)				ATTGGCAGCAGACAGGGAGTC	0.488			NA											6	13					0	0	0.004482	0	0
TRIM50	135892	broad.mit.edu	37	7	72734212	72734212	+	Silent	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr7:72734212C>T	uc010lbd.1	-	3	554	c.429G>A	c.(427-429)CTG>CTA	p.L143L	FKBP6_uc003twz.2_Intron|TRIM50_uc003txy.1_Silent_p.L143L|TRIM50_uc003txz.1_Silent_p.L143L	NM_178125	NP_835226	Q86XT4	TRI50_HUMAN	tripartite motif protein 50A	143	Potential.					cytoplasm|intracellular membrane-bounded organelle	ligase activity|zinc ion binding			skin(1)	1						GCTCCTGCTTCAGCTCAGAGA	0.597			NA											28	121					0	0	0.007291	0	0
DTX2	113878	broad.mit.edu	37	7	76111922	76111922	+	Silent	SNP	T	T	C	rs141436878		TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr7:76111922T>C	uc003uff.3	+	5	922	c.366T>C	c.(364-366)ACT>ACC	p.T122T	DTX2_uc011kgk.1_Silent_p.T31T|DTX2_uc003ufg.3_Silent_p.T122T|DTX2_uc003ufh.3_Silent_p.T122T|DTX2_uc003ufj.3_Silent_p.T122T	NM_020892	NP_065943	Q86UW9	DTX2_HUMAN	deltex 2 isoform a	122	WWE 2.				Notch signaling pathway	cytoplasm|nucleus	protein binding|zinc ion binding			ovary(1)|skin(1)	2						GCTCCTGGACTGCCTATGAAG	0.632			NA											35	50					0	0	0.013726	0	0
SEMA3C	10512	broad.mit.edu	37	7	80546044	80546044	+	Silent	SNP	A	A	G			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr7:80546044A>G	uc003uhj.2	-	2	616	c.54T>C	c.(52-54)TGT>TGC	p.C18C	SEMA3C_uc011kgw.1_Silent_p.C36C|SEMA3C_uc011kgx.1_5'UTR	NM_006379	NP_006370	Q99985	SEM3C_HUMAN	semaphorin 3C precursor	18					immune response|response to drug	membrane	receptor activity			ovary(1)	1						ATCCTTTCACACAGATAGAAC	0.348			NA											14	26					0	0	0.003163	0	0
SEMA3D	223117	broad.mit.edu	37	7	84628913	84628913	+	Missense_Mutation	SNP	C	C	G			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr7:84628913C>G	uc003uic.2	-	17	2217	c.2177G>C	c.(2176-2178)AGC>ACC	p.S726T	SEMA3D_uc010led.2_Missense_Mutation_p.S726T|SEMA3D_uc003uib.2_Missense_Mutation_p.S365T	NM_152754	NP_689967	O95025	SEM3D_HUMAN	semaphorin 3D precursor	726					cell differentiation|nervous system development	extracellular region|membrane	receptor activity			ovary(3)|large_intestine(2)	5						CTGGTCGAGGCTGAAGTTTGG	0.512	Ovarian(63;442 1191 17318 29975 31528)		NA											7	44					0	0	0.001984	0	0
TRRAP	8295	broad.mit.edu	37	7	98509822	98509822	+	Missense_Mutation	SNP	G	G	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr7:98509822G>A	uc003upp.2	+	18	2394	c.2185G>A	c.(2185-2187)GAA>AAA	p.E729K	TRRAP_uc011kis.1_Missense_Mutation_p.E729K|TRRAP_uc003upr.2_Missense_Mutation_p.E421K	NM_003496	NP_003487	Q9Y4A5	TRRAP_HUMAN	transformation/transcription domain-associated	729					histone deubiquitination|histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|PCAF complex|STAGA complex|transcription factor TFTC complex	phosphotransferase activity, alcohol group as acceptor|protein binding|transcription cofactor activity			ovary(9)|large_intestine(8)|central_nervous_system(6)|skin(6)|stomach(5)|upper_aerodigestive_tract(1)|lung(1)|liver(1)	37	all_cancers(62;6.96e-09)|all_epithelial(64;4.86e-09)|Lung NSC(181;0.01)|all_lung(186;0.016)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)			AGCTGAAAATGAACAAATGCT	0.368			NA											23	37					0	0	0.00333	0	0
CYP3A7	1551	broad.mit.edu	37	7	99308411	99308411	+	Missense_Mutation	SNP	G	G	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr7:99308411G>T	uc003uru.2	-	10	1075	c.970C>A	c.(970-972)CAC>AAC	p.H324N	ZNF498_uc003urn.2_Intron|CYP3A5_uc003urs.2_Intron|CYP3A5_uc010lgg.2_Intron	NM_000765	NP_000756	P24462	CP3A7_HUMAN	cytochrome P450, family 3, subfamily A,	324					xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding			ovary(1)	1	Lung NSC(181;0.0144)|Esophageal squamous(72;0.0166)|all_lung(186;0.0228)					ACATCAGGGTGAGTGGCCAGT	0.448			NA											16	15					1.3612e-06	1.55873e-06	0.003163	1	0
Unknown	0	broad.mit.edu	37	7	99580996	99580996	+	Missense_Mutation	SNP	C	C	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr7:99580996C>A	uc003usi.2	+	2	317	c.306C>A	c.(304-306)AAC>AAA	p.N102K						RecName: Full=Putative zinc-alpha-2-glycoprotein-like 2; Flags: Precursor;												NA						AGACCCTGAACAACATCATGG	0.562			NA											12	15					1.61879e-10	1.99532e-10	0.013537	1	0
ZSCAN21	7589	broad.mit.edu	37	7	99662084	99662084	+	Silent	SNP	G	G	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr7:99662084G>A	uc003uso.2	+	4	1410	c.1266G>A	c.(1264-1266)GGG>GGA	p.G422G	ZSCAN21_uc003usn.1_Missense_Mutation_p.G387E|ZNF3_uc003usp.2_3'UTR	NM_145914	NP_666019	Q9Y5A6	ZSC21_HUMAN	zinc finger protein 38	422	C2H2-type 6.				positive regulation of transcription, DNA-dependent|viral reproduction	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(3)	3	Lung NSC(181;0.0211)|all_lung(186;0.0323)|Esophageal squamous(72;0.0439)		STAD - Stomach adenocarcinoma(171;0.129)			AGGAGTGTGGGAAAGCCTTCA	0.512			NA											18	23					0	0	0.006122	0	0
CUX1	1523	broad.mit.edu	37	7	101671405	101671405	+	Silent	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr7:101671405C>T	uc003uyx.3	+	3	207	c.169C>T	c.(169-171)CTG>TTG	p.L57L	CUX1_uc003uys.3_Silent_p.L68L|CUX1_uc003uyt.2_Silent_p.L68L|CUX1_uc011kkn.1_Silent_p.L31L|CUX1_uc003uyw.2_Silent_p.L68L|CUX1_uc003uyv.2_Intron|CUX1_uc003uyu.2_Silent_p.L68L	NM_181552	NP_853530	P39880	CUX1_HUMAN	cut-like homeobox 1 isoform a	57	Potential.				negative regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(5)|pancreas(1)|central_nervous_system(1)|skin(1)	8						AGCGCCGCTGCTGAAGAGTTT	0.473			NA											10	30					0	0	0.013537	0	0
NRCAM	4897	broad.mit.edu	37	7	107816974	107816974	+	Missense_Mutation	SNP	A	A	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr7:107816974A>T	uc003vfb.2	-	27	3523	c.3052T>A	c.(3052-3054)TTA>ATA	p.L1018I	NRCAM_uc003vfc.2_Missense_Mutation_p.L1002I|NRCAM_uc011kmk.1_Missense_Mutation_p.L1013I|NRCAM_uc003vfd.2_Missense_Mutation_p.L994I|NRCAM_uc003vfe.2_Missense_Mutation_p.L994I|NRCAM_uc011kmj.1_5'UTR	NM_001037132	NP_001032209	Q92823	NRCAM_HUMAN	neuronal cell adhesion molecule isoform A	1018	Fibronectin type-III 4.|Extracellular (Potential).				angiogenesis|axon guidance|axonal fasciculation|cell-cell adhesion|central nervous system development|clustering of voltage-gated sodium channels|neuron migration|positive regulation of neuron differentiation|regulation of axon extension|synapse assembly	external side of plasma membrane|integral to plasma membrane	ankyrin binding			ovary(3)|breast(2)	5						CTGAAATTTAAATTTTTTAAA	0.363			NA											24	18					0	0	0.00278	0	0
C7orf66	154907	broad.mit.edu	37	7	108524185	108524185	+	Missense_Mutation	SNP	T	T	C			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr7:108524185T>C	uc003vfo.2	-	2	275	c.227A>G	c.(226-228)CAG>CGG	p.Q76R		NM_001024607	NP_001019778	A4D0T2	CG066_HUMAN	hypothetical protein LOC154907	76						integral to membrane				ovary(2)	2						TCTGTATCTCTGATCCATCAT	0.403			NA											3	39					0	0	0.004672	0	0
DOCK4	9732	broad.mit.edu	37	7	111379521	111379521	+	Missense_Mutation	SNP	T	T	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr7:111379521T>A	uc003vfx.2	-	47	5295	c.5026A>T	c.(5026-5028)ACC>TCC	p.T1676S	DOCK4_uc011kml.1_Missense_Mutation_p.T557S|DOCK4_uc011kmm.1_Missense_Mutation_p.T583S|DOCK4_uc003vfw.2_Missense_Mutation_p.T1126S|DOCK4_uc003vfy.2_Missense_Mutation_p.T1721S|DOCK4_uc003vfv.2_5'UTR	NM_014705	NP_055520	Q8N1I0	DOCK4_HUMAN	dedicator of cytokinesis 4	1676	Ser-rich.				cell chemotaxis	cytosol|endomembrane system|membrane|stereocilium	GTP binding|guanyl-nucleotide exchange factor activity|PDZ domain binding|Rac GTPase activator activity|Rac GTPase binding|receptor tyrosine kinase binding|SH3 domain binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)	4		Acute lymphoblastic leukemia(1;0.0441)				AAGCTTGAGGTAGATGGACTT	0.468			NA											2	0					0	0	0.004672	0	0
PTPRZ1	5803	broad.mit.edu	37	7	121638051	121638051	+	Missense_Mutation	SNP	G	G	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr7:121638051G>T	uc003vjy.2	+	10	1626	c.1231G>T	c.(1231-1233)GAT>TAT	p.D411Y	PTPRZ1_uc003vjz.2_Missense_Mutation_p.D411Y	NM_002851	NP_002842	P23471	PTPRZ_HUMAN	protein tyrosine phosphatase, receptor-type,	411	Extracellular (Potential).				central nervous system development	integral to plasma membrane	protein binding|protein tyrosine/threonine phosphatase activity|transmembrane receptor protein tyrosine phosphatase activity			ovary(3)|large_intestine(2)|lung(2)|central_nervous_system(1)|kidney(1)	9						CATGCCTACTGATAATCCTGG	0.348			NA											5	10					0.000602214	0.000636401	0.000602	1	0
POT1	25913	broad.mit.edu	37	7	124499043	124499043	+	Missense_Mutation	SNP	C	C	G			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr7:124499043C>G	uc003vlm.2	-	9	1271	c.670G>C	c.(670-672)GAT>CAT	p.D224H	POT1_uc011koe.1_RNA|POT1_uc003vlk.2_RNA|POT1_uc003vll.2_RNA|POT1_uc003vlo.2_Missense_Mutation_p.D93H|POT1_uc003vln.2_RNA	NM_015450	NP_056265	Q9NUX5	POTE1_HUMAN	protection of telomeres 1 isoform 1	224					DNA duplex unwinding|negative regulation of telomere maintenance via telomerase|positive regulation of DNA strand elongation|positive regulation of helicase activity|positive regulation of telomerase activity|positive regulation of telomere maintenance via telomerase|telomere capping|telomere formation via telomerase|telomere maintenance via telomerase	nuclear telomere cap complex|nucleoplasm	DEAD/H-box RNA helicase binding|single-stranded telomeric DNA binding|telomerase inhibitor activity			central_nervous_system(1)	1						ACATGGTTATCGTAGACTAAA	0.318	Esophageal Squamous(149;1032 1141 16047 36610 40540 42429 44687 51642)		NA											3	16					0	0	0.006214	0	0
NRF1	4899	broad.mit.edu	37	7	129357178	129357178	+	Missense_Mutation	SNP	G	G	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr7:129357178G>T	uc003voz.2	+	9	1302	c.1185G>T	c.(1183-1185)GAG>GAT	p.E395D	NRF1_uc003vpa.2_Missense_Mutation_p.E395D|NRF1_uc011kpa.1_Missense_Mutation_p.E234D|NRF1_uc003vpb.2_Missense_Mutation_p.E395D	NM_005011	NP_005002	Q16656	NRF1_HUMAN	nuclear respiratory factor 1	395	Required for transcriptional activation.				generation of precursor metabolites and energy|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	DNA binding			ovary(1)	1						CTTCTCAGGAGATGCAGCAGG	0.572			NA											16	26					1.3612e-06	1.55873e-06	0.003163	1	0
PRSS1	5644	broad.mit.edu	37	7	142460350	142460350	+	Missense_Mutation	SNP	T	T	C			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr7:142460350T>C	uc003wak.2	+	4	540	c.523T>C	c.(523-525)TAC>CAC	p.Y175H	uc011krr.1_Intron|uc003vzp.2_Intron|uc011ksh.1_Intron|uc011ksi.1_Intron|uc003vzw.1_Intron|uc010loj.1_Intron|uc003wad.2_Intron|uc003wag.1_Intron|TRY6_uc011ksn.1_Intron|PRSS1_uc003wam.2_Missense_Mutation_p.Y115H	NM_002769	NP_002760	P07477	TRY1_HUMAN	protease, serine, 1 preproprotein	175	Peptidase S1.				digestion|proteolysis	extracellular space	metal ion binding|protein binding|serine-type endopeptidase activity			large_intestine(1)|central_nervous_system(1)	2	Melanoma(164;0.047)	all_cancers(3;2.14e-49)|Acute lymphoblastic leukemia(3;7.3e-185)|all_hematologic(3;1.1e-165)	all cancers(2;0.000126)|Colorectal(2;0.000157)|Epithelial(2;0.000191)|COAD - Colon adenocarcinoma(2;0.00189)			TGAAGCCTCCTACCCTGGAAA	0.532			NA							Hereditary_Pancreatitis				68	159					0	0	0.01441	0	0
EZH2	2146	broad.mit.edu	37	7	148513776	148513776	+	Missense_Mutation	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr7:148513776C>T	uc003wfd.1	-	12	1656	c.1490G>A	c.(1489-1491)CGG>CAG	p.R497Q	EZH2_uc011kug.1_Missense_Mutation_p.R488Q|EZH2_uc003wfb.1_Missense_Mutation_p.R502Q|EZH2_uc003wfc.1_Missense_Mutation_p.R458Q|EZH2_uc011kuh.1_Missense_Mutation_p.R488Q|EZH2_uc011kui.1_3'UTR	NM_004456	NP_004447	Q15910	EZH2_HUMAN	enhancer of zeste 2 isoform a	497					negative regulation of retinoic acid receptor signaling pathway|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	ESC/E(Z) complex	DNA binding|histone-lysine N-methyltransferase activity|protein binding			haematopoietic_and_lymphoid_tissue(180)|skin(2)|large_intestine(1)	183	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00239)			ACAGACTCACCGGTGTTTCCT	0.453			NA	Mis		DLBCL								20	22					0	0	0.010504	0	0
ZNF425	155054	broad.mit.edu	37	7	148802277	148802277	+	Missense_Mutation	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr7:148802277C>T	uc003wfj.2	-	4	759	c.686G>A	c.(685-687)GGG>GAG	p.G229E		NM_001001661	NP_001001661	Q6IV72	ZN425_HUMAN	zinc finger protein 425	229					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			breast(2)|ovary(1)	3	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00463)			TTCGGACTTCCCTCTGGACGA	0.532			NA											34	30					0	0	0.003271	0	0
ABCB8	11194	broad.mit.edu	37	7	150739143	150739143	+	Silent	SNP	G	G	T	rs138648802	by1000genomes	TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr7:150739143G>T	uc003wil.3	+	15	1857	c.1764G>T	c.(1762-1764)GCG>GCT	p.A588A	ABCB8_uc010lpw.1_3'UTR|ABCB8_uc010lpx.2_Silent_p.A571A|ABCB8_uc011kvd.1_Silent_p.A483A|ABCB8_uc003wim.3_Silent_p.A366A|ABCB8_uc003wik.3_Silent_p.A571A	NM_007188	NP_009119	Q9NUT2	ABCB8_HUMAN	ATP-binding cassette, sub-family B, member 8	588	ABC transporter.					ATP-binding cassette (ABC) transporter complex|integral to membrane|membrane fraction|mitochondrial inner membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(2)|upper_aerodigestive_tract(1)	3			OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		CCCGGGAAGCGAATGCTCACG	0.607			NA											19	65					5.35267e-07	6.18796e-07	0.007413	1	0
FASTK	10922	broad.mit.edu	37	7	150774063	150774063	+	Silent	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr7:150774063C>T	uc003wix.1	-	9	1577	c.1479G>A	c.(1477-1479)GTG>GTA	p.V493V	uc011kvf.1_5'Flank|FASTK_uc003wiw.1_Silent_p.V254V|FASTK_uc003wiy.1_Silent_p.V352V|FASTK_uc003wiz.1_Silent_p.V466V|FASTK_uc003wja.1_3'UTR	NM_006712	NP_006703	Q14296	FASTK_HUMAN	Fas-activated serine/threonine kinase isoform 1	493	RAP.				apoptosis|induction of apoptosis by extracellular signals|regulation of RNA splicing		ATP binding|Fas-activated serine/threonine kinase activity|protein binding			lung(2)|stomach(2)	4			OV - Ovarian serous cystadenocarcinoma(82;0.00989)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)|LUSC - Lung squamous cell carcinoma(290;0.0718)|Lung(243;0.138)		AGCCCAGCAGCACCCGGCCGT	0.716			NA											14	39					0	0	0.001855	0	0
MLL3	58508	broad.mit.edu	37	7	151945082	151945082	+	Missense_Mutation	SNP	G	G	C			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr7:151945082G>C	uc003wla.2	-	14	2656	c.2437C>G	c.(2437-2439)CCA>GCA	p.P813A		NM_170606	NP_733751	Q8NEZ4	MLL3_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 3	813					intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			large_intestine(27)|pancreas(13)|ovary(9)|central_nervous_system(8)|breast(3)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	63	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)		TAAGTTGTTGGCATGATGTTT	0.448	Colon(68;14 1149 1884 27689 34759)		NA	N		medulloblastoma								8	124					0	0	0.00308	0	0
TUSC3	7991	broad.mit.edu	37	8	15517098	15517098	+	Missense_Mutation	SNP	G	G	C			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr8:15517098G>C	uc003wwt.2	+	4	719	c.509G>C	c.(508-510)AGA>ACA	p.R170T	TUSC3_uc003wwr.2_Missense_Mutation_p.R170T|TUSC3_uc003wws.2_Missense_Mutation_p.R170T|TUSC3_uc003wwu.2_Missense_Mutation_p.R170T|TUSC3_uc003wwv.2_Missense_Mutation_p.R170T|TUSC3_uc003www.2_Missense_Mutation_p.R170T|TUSC3_uc003wwx.2_RNA|TUSC3_uc003wwy.2_Missense_Mutation_p.R170T	NM_006765	NP_006756	Q13454	TUSC3_HUMAN	tumor suppressor candidate 3 isoform a	170					cell redox homeostasis|post-translational protein modification|protein N-linked glycosylation via asparagine	integral to membrane|oligosaccharyltransferase complex				ovary(2)|central_nervous_system(1)	3				Colorectal(111;0.113)		GACCTCCAAAGAATTGGATTT	0.393			NA											5	16					0	0	0.001984	0	0
ADAM7	8756	broad.mit.edu	37	8	24359024	24359024	+	Nonsense_Mutation	SNP	G	G	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr8:24359024G>T	uc003xeb.2	+	20	2256	c.2143G>T	c.(2143-2145)GGA>TGA	p.G715*	ADAM7_uc003xec.2_Nonsense_Mutation_p.G487*	NM_003817	NP_003808	Q9H2U9	ADAM7_HUMAN	a disintegrin and metalloproteinase domain 7	715	Cytoplasmic (Potential).				proteolysis	integral to membrane	metalloendopeptidase activity|zinc ion binding			skin(3)|ovary(1)|kidney(1)	5		Prostate(55;0.0181)		Colorectal(74;0.0199)|COAD - Colon adenocarcinoma(73;0.0754)|BRCA - Breast invasive adenocarcinoma(99;0.182)		GGAGAACAAAGGATACTTTGG	0.323			NA											11	21					0.00136819	0.00143231	0.013537	1	0
TEX15	56154	broad.mit.edu	37	8	30704584	30704584	+	Silent	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr8:30704584C>T	uc003xil.2	-	1	1950	c.1950G>A	c.(1948-1950)ACG>ACA	p.T650T		NM_031271	NP_112561	Q9BXT5	TEX15_HUMAN	testis expressed 15	650										ovary(3)|upper_aerodigestive_tract(2)|skin(2)	7				KIRC - Kidney renal clear cell carcinoma(542;0.0918)|Kidney(114;0.111)		TATTTTTATCCGTATCAATTT	0.299			NA											9	19					0	0	0.006214	0	0
UNC5D	137970	broad.mit.edu	37	8	35541202	35541202	+	Silent	SNP	C	C	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr8:35541202C>A	uc003xjr.1	+	5	1036	c.708C>A	c.(706-708)ATC>ATA	p.I236I	UNC5D_uc003xjs.1_Silent_p.I231I|UNC5D_uc003xjt.1_Silent_p.I5I	NM_080872	NP_543148	Q6UXZ4	UNC5D_HUMAN	unc-5 homolog D precursor	236	Extracellular (Potential).|Ig-like C2-type.				apoptosis|axon guidance	integral to membrane	receptor activity			upper_aerodigestive_tract(2)|ovary(2)|pancreas(1)|skin(1)	6				READ - Rectum adenocarcinoma(1;1.31e-05)|Colorectal(1;0.000723)		CAGCCAACATCGTGGCTAAGA	0.532			NA											9	13					2.17888e-05	2.40588e-05	0.006214	1	0
KCNU1	157855	broad.mit.edu	37	8	36675196	36675196	+	Missense_Mutation	SNP	G	G	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr8:36675196G>T	uc010lvw.2	+	10	1111	c.1024G>T	c.(1024-1026)GTG>TTG	p.V342L	KCNU1_uc003xjw.2_RNA	NM_001031836	NP_001027006	A8MYU2	KCNU1_HUMAN	potassium channel, subfamily U, member 1	342	RCK N-terminal.|Cytoplasmic (Potential).					voltage-gated potassium channel complex	binding|large conductance calcium-activated potassium channel activity|voltage-gated potassium channel activity			ovary(1)	1				KIRC - Kidney renal clear cell carcinoma(67;0.0504)|Kidney(114;0.0634)		AAACATCACTGTGGACAGTGT	0.458			NA											20	27					7.41877e-09	8.93287e-09	0.012319	1	0
ADRB3	155	broad.mit.edu	37	8	37821747	37821747	+	Missense_Mutation	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr8:37821747C>T	uc003xkr.1	-	2	1413	c.1216G>A	c.(1216-1218)GGA>AGA	p.G406R		NM_000025	NP_000016	P13945	ADRB3_HUMAN	adrenergic, beta-3-, receptor	406	Cytoplasmic (By similarity).				carbohydrate metabolic process|energy reserve metabolic process|positive regulation of MAPKKK cascade	integral to plasma membrane|receptor complex	beta3-adrenergic receptor activity|protein homodimerization activity			lung(2)	2	Colorectal(12;0.00627)	Lung NSC(58;0.118)|all_lung(54;0.195)	LUSC - Lung squamous cell carcinoma(8;1.37e-11)		Norepinephrine(DB00368)|Pindolol(DB00960)|Propranolol(DB00571)	TAAGAAACTCCCCAAGAAGCC	0.507			NA											6	16					0	0	0.001984	0	0
MYST3	7994	broad.mit.edu	37	8	41834584	41834584	+	Silent	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr8:41834584C>T	uc010lxb.2	-	8	1849	c.1305G>A	c.(1303-1305)GAG>GAA	p.E435E	MYST3_uc010lxc.2_Silent_p.E435E|MYST3_uc003xon.3_Silent_p.E435E|MYST3_uc010lxd.2_Silent_p.E435E	NM_001099412	NP_001092882	Q92794	MYST3_HUMAN	MYST histone acetyltransferase (monocytic	435	Interaction with RUNX1-1.				histone H3 acetylation|myeloid cell differentiation|negative regulation of transcription, DNA-dependent|nucleosome assembly|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	MOZ/MORF histone acetyltransferase complex|nucleosome	DNA binding|histone acetyltransferase activity|transcription coactivator activity|transcription factor binding|zinc ion binding			ovary(4)|pancreas(1)|central_nervous_system(1)|skin(1)	7	all_epithelial(6;1.12e-27)|all_lung(13;3.94e-12)|Lung NSC(13;6.54e-11)|Ovarian(28;0.00744)|Prostate(17;0.0119)|Colorectal(14;0.0221)|Lung SC(25;0.211)	all_lung(54;0.000294)|Lung NSC(58;0.00105)|Hepatocellular(245;0.0524)|Esophageal squamous(32;0.0954)|Renal(179;0.0983)	Epithelial(1;2.82e-19)|all cancers(1;1.15e-16)|BRCA - Breast invasive adenocarcinoma(8;9.17e-11)|OV - Ovarian serous cystadenocarcinoma(14;9.4e-05)|Colorectal(10;0.000728)|Lung(22;0.00153)|LUSC - Lung squamous cell carcinoma(45;0.00741)|COAD - Colon adenocarcinoma(11;0.0171)			TTCGATATTGCTCAGAGTAGT	0.448			NA											20	31					0	0	0.007413	0	0
IKBKB	3551	broad.mit.edu	37	8	42176906	42176906	+	Nonsense_Mutation	SNP	G	G	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr8:42176906G>T	uc003xow.1	+	14	1660	c.1483G>T	c.(1483-1485)GAG>TAG	p.E495*	IKBKB_uc010lxh.1_Nonsense_Mutation_p.E390*|IKBKB_uc011lco.1_RNA|IKBKB_uc010lxj.1_Nonsense_Mutation_p.E272*|IKBKB_uc003xox.1_Nonsense_Mutation_p.E216*|IKBKB_uc011lcp.1_RNA|IKBKB_uc011lcq.1_Nonsense_Mutation_p.E493*|IKBKB_uc010lxi.1_RNA|IKBKB_uc011lcr.1_Nonsense_Mutation_p.E436*	NM_001556	NP_001547	O14920	IKKB_HUMAN	inhibitor of nuclear factor kappa B kinase beta	495					anti-apoptosis|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of transcription, DNA-dependent|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	CD40 receptor complex|cytosol|internal side of plasma membrane|membrane raft	ATP binding|identical protein binding|IkappaB kinase activity			breast(3)|ovary(2)|lung(1)|skin(1)	7	all_cancers(6;1.42e-24)|all_epithelial(6;1.02e-25)|all_lung(13;6.21e-12)|Lung NSC(13;1.04e-10)|Ovarian(28;0.00769)|Prostate(17;0.0119)|Colorectal(14;0.0468)|Lung SC(25;0.211)	all_lung(54;0.000434)|Lung NSC(58;0.00161)|Hepatocellular(245;0.0524)|Renal(179;0.0822)|Esophageal squamous(32;0.0954)	BRCA - Breast invasive adenocarcinoma(8;1.37e-10)|Colorectal(10;0.00102)|OV - Ovarian serous cystadenocarcinoma(14;0.00168)|Lung(22;0.00467)|LUSC - Lung squamous cell carcinoma(45;0.024)|COAD - Colon adenocarcinoma(11;0.0264)		Arsenic trioxide(DB01169)|Auranofin(DB00995)	GATTGACCTGGAGAAGTACAG	0.428			NA									OREG0018747	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	28	44					1.39806e-14	1.82061e-14	0.008361	1	0
VDAC3	7419	broad.mit.edu	37	8	42259420	42259420	+	Silent	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr8:42259420C>T	uc011lct.1	+	7	581	c.438C>T	c.(436-438)TTC>TTT	p.F146F	VDAC3_uc010lxk.2_3'UTR|VDAC3_uc003xpc.2_Silent_p.F147F	NM_005662	NP_005653	Q9Y277	VDAC3_HUMAN	voltage-dependent anion channel 3 isoform b	146					adenine transport	mitochondrial outer membrane|pore complex	nucleotide binding|porin activity|protein binding|voltage-gated anion channel activity			upper_aerodigestive_tract(1)	1	all_cancers(6;3.86e-23)|all_lung(13;6.47e-12)|Lung NSC(13;1.08e-10)|Ovarian(28;0.00769)|Prostate(17;0.0119)|Lung SC(25;0.211)	all_lung(54;0.00671)|Lung NSC(58;0.0184)|Esophageal squamous(32;0.131)|Hepatocellular(245;0.133)|Renal(179;0.151)	BRCA - Breast invasive adenocarcinoma(8;3.48e-10)|OV - Ovarian serous cystadenocarcinoma(14;0.00266)|Lung(22;0.00849)|LUSC - Lung squamous cell carcinoma(45;0.024)		Dihydroxyaluminium(DB01375)	TGTTGGCCTTCGAAGGGTGGC	0.463			NA											13	92					0	0	0.00245	0	0
SNTG1	54212	broad.mit.edu	37	8	51363276	51363276	+	Missense_Mutation	SNP	G	G	T	rs145685246		TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr8:51363276G>T	uc010lxy.1	+	9	721	c.350G>T	c.(349-351)AGA>ATA	p.R117I	SNTG1_uc003xqs.1_Missense_Mutation_p.R117I|SNTG1_uc010lxz.1_Missense_Mutation_p.R117I|SNTG1_uc011ldl.1_RNA	NM_018967	NP_061840	Q9NSN8	SNTG1_HUMAN	syntrophin, gamma 1	117	PDZ.				cell communication	cytoplasm|cytoskeleton|nucleus|ruffle membrane|syntrophin complex	actin binding|protein C-terminus binding			ovary(5)	5		all_cancers(86;0.00754)|all_epithelial(80;9.76e-05)|Lung NSC(129;0.000865)|all_lung(136;0.00249)|Colorectal(162;0.22)				AGAAAATGTAGACATGAAGAA	0.323			NA											4	8					0.00024832	0.000265313	0.009096	1	0
ATP6V1H	51606	broad.mit.edu	37	8	54708348	54708348	+	Missense_Mutation	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr8:54708348C>T	uc003xrl.2	-	9	881	c.729G>A	c.(727-729)ATG>ATA	p.M243I	ATP6V1H_uc003xrk.2_Missense_Mutation_p.M203I|ATP6V1H_uc003xrm.2_Missense_Mutation_p.M243I|ATP6V1H_uc003xrn.2_Missense_Mutation_p.M225I|ATP6V1H_uc011ldv.1_Missense_Mutation_p.M163I|ATP6V1H_uc010lyd.2_Missense_Mutation_p.M179I	NM_213620	NP_998785	Q9UI12	VATH_HUMAN	ATPase, H+ transporting, lysosomal 50/57kDa, V1	243					ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|endocytosis|insulin receptor signaling pathway|interspecies interaction between organisms|regulation of defense response to virus by virus|transferrin transport|vacuolar acidification|viral reproduction	cytosol|plasma membrane|vacuolar proton-transporting V-type ATPase, V1 domain	enzyme regulator activity|protein binding|proton-transporting ATPase activity, rotational mechanism				0		all_epithelial(80;0.0487)|Lung NSC(129;0.109)|all_lung(136;0.181)	OV - Ovarian serous cystadenocarcinoma(7;2.79e-06)|Epithelial(17;0.000629)|all cancers(17;0.00359)			TTGAAAAAATCATTTGATACT	0.378			NA											6	34					0	0	0.001984	0	0
SDR16C5	195814	broad.mit.edu	37	8	57218183	57218183	+	Missense_Mutation	SNP	A	A	C			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr8:57218183A>C	uc003xsy.1	-	6	1447	c.809T>G	c.(808-810)TTG>TGG	p.L270W	SDR16C5_uc010lyk.1_Missense_Mutation_p.L270W|SDR16C5_uc010lyl.1_Missense_Mutation_p.L226W	NM_138969	NP_620419	Q8N3Y7	RDHE2_HUMAN	epidermal retinal dehydrogenase 2	270	Helical; (Potential).				detection of light stimulus involved in visual perception|keratinocyte proliferation|retinal metabolic process|retinol metabolic process	endoplasmic reticulum membrane|integral to membrane|integral to membrane of membrane fraction	binding|retinol dehydrogenase activity			ovary(1)|central_nervous_system(1)|skin(1)	3						GAAGTATAACAACTTTGGCAT	0.358			NA											10	19					0	0	0.008291	0	0
GGH	8836	broad.mit.edu	37	8	63930053	63930053	+	Silent	SNP	T	T	C			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr8:63930053T>C	uc003xuw.2	-	8	1117	c.834A>G	c.(832-834)GAA>GAG	p.E278E		NM_003878	NP_003869	Q92820	GGH_HUMAN	gamma-glutamyl hydrolase precursor	278	Gamma-glutamyl hydrolase.				glutamine metabolic process	extracellular space|lysosome|melanosome	gamma-glutamyl-peptidase activity				0	Breast(64;0.0716)	all_cancers(86;0.189)|Lung NSC(129;0.0324)|all_lung(136;0.0593)|all_epithelial(80;0.131)			Folic Acid(DB00158)|L-Glutamic Acid(DB00142)	TCATATTACCTTCATTAACAA	0.358			NA											7	36					0	0	0.008291	0	0
EYA1	2138	broad.mit.edu	37	8	72123457	72123457	+	Missense_Mutation	SNP	C	C	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr8:72123457C>A	uc003xys.3	-	16	1919	c.1632G>T	c.(1630-1632)AGG>AGT	p.R544S	EYA1_uc003xyr.3_Missense_Mutation_p.R509S|EYA1_uc003xyt.3_Missense_Mutation_p.R511S|EYA1_uc010lzf.2_Missense_Mutation_p.R471S|EYA1_uc003xyu.2_Missense_Mutation_p.R544S|EYA1_uc011lfe.1_Missense_Mutation_p.R538S|EYA1_uc003xyv.2_Missense_Mutation_p.R422S	NM_172058	NP_742055	Q99502	EYA1_HUMAN	eyes absent 1 isoform b	544					double-strand break repair|histone dephosphorylation|positive regulation of DNA repair|protein sumoylation|regulation of transcription, DNA-dependent|response to ionizing radiation|sensory perception of sound|transcription, DNA-dependent	cytoplasm|nucleus	metal ion binding|protein tyrosine phosphatase activity			ovary(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	5	Breast(64;0.046)		Epithelial(68;0.0837)|all cancers(69;0.247)			TTCTTCCAAACCTTTGAATTA	0.358			NA											19	33					1.15919e-05	1.28779e-05	0.008871	1	0
KCNB2	9312	broad.mit.edu	37	8	73480521	73480521	+	Missense_Mutation	SNP	G	G	C			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr8:73480521G>C	uc003xzb.2	+	2	1140	c.552G>C	c.(550-552)GAG>GAC	p.E184D		NM_004770	NP_004761	Q92953	KCNB2_HUMAN	potassium voltage-gated channel, Shab-related	184	Cytoplasmic (Potential).				regulation of smooth muscle contraction	voltage-gated potassium channel complex	delayed rectifier potassium channel activity|protein binding			skin(3)|large_intestine(1)|pancreas(1)|ovary(1)|central_nervous_system(1)	7	Breast(64;0.137)		Epithelial(68;0.105)			ACTTGCTGGAGAAACCTAACT	0.458			NA											9	66					0	0	0.004482	0	0
ZFHX4	79776	broad.mit.edu	37	8	77617456	77617456	+	Missense_Mutation	SNP	G	G	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr8:77617456G>T	uc003yav.2	+	2	1520	c.1133G>T	c.(1132-1134)GGC>GTC	p.G378V	ZFHX4_uc003yat.1_Missense_Mutation_p.G378V|ZFHX4_uc003yau.1_Missense_Mutation_p.G378V|ZFHX4_uc003yaw.1_Missense_Mutation_p.G378V	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	378						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			TTGCCGGCTGGCTTTGCCTTC	0.522			NA								HNSCC(33;0.089)			11	44					5.50884e-06	6.16718e-06	0.013537	1	0
ZFHX4	79776	broad.mit.edu	37	8	77620118	77620118	+	Missense_Mutation	SNP	C	C	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr8:77620118C>A	uc003yav.2	+	3	3237	c.2850C>A	c.(2848-2850)CAC>CAA	p.H950Q	ZFHX4_uc003yat.1_Missense_Mutation_p.H950Q|ZFHX4_uc003yau.1_Missense_Mutation_p.H976Q|ZFHX4_uc003yaw.1_Missense_Mutation_p.H950Q	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	950						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			TGGTGGCTCACATTAAAGAAG	0.443			NA								HNSCC(33;0.089)			20	41					8.10497e-08	9.55229e-08	0.010504	1	0
ZFHX4	79776	broad.mit.edu	37	8	77768223	77768223	+	Silent	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr8:77768223C>T	uc003yav.2	+	10	9318	c.8931C>T	c.(8929-8931)ATC>ATT	p.I2977I	ZFHX4_uc003yau.1_Silent_p.I3022I|ZFHX4_uc003yaw.1_Silent_p.I2977I	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	2977	C2H2-type 18.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			GCTTGTCCATCAGAGATCACA	0.507			NA								HNSCC(33;0.089)			12	28					0	0	0.013537	0	0
MMP16	4325	broad.mit.edu	37	8	89131063	89131063	+	Missense_Mutation	SNP	T	T	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr8:89131063T>A	uc003yeb.3	-	5	1019	c.737A>T	c.(736-738)CAT>CTT	p.H246L	MMP16_uc003yec.2_Missense_Mutation_p.H246L	NM_005941	NP_005932	P51512	MMP16_HUMAN	matrix metalloproteinase 16 isoform 1	246	Extracellular (Potential).	Zinc; catalytic (By similarity).			collagen catabolic process|proteolysis	cell surface|integral to plasma membrane|proteinaceous extracellular matrix	calcium ion binding|enzyme activator activity|metalloendopeptidase activity|zinc ion binding			upper_aerodigestive_tract(2)|ovary(2)|central_nervous_system(1)|urinary_tract(1)|skin(1)|kidney(1)	8						TCCCAGTTCATGGACTGCTAC	0.383			NA											8	17					0	0	0.00308	0	0
VPS13B	157680	broad.mit.edu	37	8	100514053	100514053	+	Missense_Mutation	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr8:100514053C>T	uc003yiv.2	+	26	4120	c.4009C>T	c.(4009-4011)CTC>TTC	p.L1337F	VPS13B_uc003yiw.2_Missense_Mutation_p.L1337F|VPS13B_uc003yiu.1_Missense_Mutation_p.L1337F|VPS13B_uc003yix.1_Missense_Mutation_p.L807F	NM_017890	NP_060360	Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13B isoform 5	1337					protein transport					ovary(7)|skin(4)|lung(3)|central_nervous_system(2)|pancreas(2)|breast(1)|kidney(1)	20	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			TACTATAAAGCTCTTTGCTCC	0.313	Colon(161;2205 2542 7338 31318)		NA											11	89					0	0	0.008291	0	0
RIMS2	9699	broad.mit.edu	37	8	104987722	104987722	+	Missense_Mutation	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr8:104987722C>T	uc003yls.2	+	14	2490	c.2249C>T	c.(2248-2250)CCT>CTT	p.P750L	RIMS2_uc003ylp.2_Missense_Mutation_p.P972L|RIMS2_uc003ylw.2_Missense_Mutation_p.P764L|RIMS2_uc003ylq.2_Missense_Mutation_p.P764L|RIMS2_uc003ylr.2_Missense_Mutation_p.P811L|RIMS2_uc003ylt.2_Missense_Mutation_p.P357L	NM_014677	NP_055492	Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	1034					intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			ovary(6)|lung(2)|breast(2)|skin(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	15			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			CCCAGTGTCCCTCCTCCACAA	0.328			NA								HNSCC(12;0.0054)			3	13					0	0	0.004672	0	0
ANGPT1	284	broad.mit.edu	37	8	108315484	108315484	+	Missense_Mutation	SNP	A	A	G			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr8:108315484A>G	uc003ymn.2	-	5	1388	c.920T>C	c.(919-921)ATG>ACG	p.M307T	ANGPT1_uc011lhv.1_Missense_Mutation_p.M107T|ANGPT1_uc003ymo.2_Missense_Mutation_p.M306T|ANGPT1_uc003ymp.3_Missense_Mutation_p.M106T	NM_001146	NP_001137	Q15389	ANGP1_HUMAN	angiopoietin 1 precursor	307	Fibrinogen C-terminal.				activation of transmembrane receptor protein tyrosine kinase activity|anti-apoptosis|blood coagulation|cell differentiation|heparin biosynthetic process|leukocyte migration|negative regulation of cell adhesion|negative regulation of endothelial cell apoptosis|negative regulation of vascular permeability|positive chemotaxis|positive regulation of blood vessel endothelial cell migration|positive regulation of ERK1 and ERK2 cascade|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of protein kinase B signaling cascade|positive regulation of protein ubiquitination|positive regulation of receptor internalization|protein localization at cell surface|regulation of satellite cell proliferation|sprouting angiogenesis|Tie receptor signaling pathway	extracellular space|membrane raft|microvillus|plasma membrane	receptor tyrosine kinase binding			ovary(3)|skin(3)|upper_aerodigestive_tract(1)	7	Breast(1;5.06e-08)		OV - Ovarian serous cystadenocarcinoma(57;5.53e-09)			GGGTTCTGGCATATTATTAAT	0.348			NA											4	24					0	0	0.000602	0	0
NUDCD1	84955	broad.mit.edu	37	8	110305589	110305589	+	Missense_Mutation	SNP	G	G	C			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr8:110305589G>C	uc003ynb.3	-	4	735	c.624C>G	c.(622-624)ATC>ATG	p.I208M	NUDCD1_uc003yna.2_Missense_Mutation_p.I179M|NUDCD1_uc010mcl.2_Missense_Mutation_p.I121M|NUDCD1_uc010mcm.1_Missense_Mutation_p.I121M	NM_032869	NP_116258	Q96RS6	NUDC1_HUMAN	NudC domain containing 1 isoform 1	208										ovary(1)|breast(1)	2	all_neural(195;0.219)		OV - Ovarian serous cystadenocarcinoma(57;1.56e-12)			TTTTCTTACTGATAGTGACCC	0.363			NA											4	46					0	0	0.009096	0	0
PKHD1L1	93035	broad.mit.edu	37	8	110457536	110457536	+	Missense_Mutation	SNP	G	G	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr8:110457536G>A	uc003yne.2	+	38	5542	c.5438G>A	c.(5437-5439)AGT>AAT	p.S1813N		NM_177531	NP_803875	Q86WI1	PKHL1_HUMAN	fibrocystin L precursor	1813	Extracellular (Potential).|IPT/TIG 10.				immune response	cytosol|extracellular space|integral to membrane	receptor activity			ovary(9)|central_nervous_system(2)|large_intestine(1)|breast(1)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			CATTCTGTTAGTGTTGTGGTG	0.468			NA								HNSCC(38;0.096)			15	35					0	0	0.003163	0	0
CSMD3	114788	broad.mit.edu	37	8	113323366	113323366	+	Missense_Mutation	SNP	G	G	C			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr8:113323366G>C	uc003ynu.2	-	50	7885	c.7726C>G	c.(7726-7728)CCT>GCT	p.P2576A	CSMD3_uc003yns.2_Missense_Mutation_p.P1778A|CSMD3_uc003ynt.2_Missense_Mutation_p.P2536A|CSMD3_uc011lhx.1_Missense_Mutation_p.P2472A|CSMD3_uc003ynw.1_Missense_Mutation_p.P287A	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	2576	Extracellular (Potential).|Sushi 14.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						TATCCATGAGGTGGGGATTCT	0.403			NA								HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			15	34					0	0	0.00245	0	0
CSMD3	114788	broad.mit.edu	37	8	113697836	113697836	+	Missense_Mutation	SNP	G	G	C			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr8:113697836G>C	uc003ynu.2	-	15	2440	c.2281C>G	c.(2281-2283)CTT>GTT	p.L761V	CSMD3_uc003yns.2_Missense_Mutation_p.L33V|CSMD3_uc003ynt.2_Missense_Mutation_p.L721V|CSMD3_uc011lhx.1_Missense_Mutation_p.L657V	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	761	Extracellular (Potential).|CUB 4.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						TTGAAAGAAAGATGTATCCGG	0.428			NA								HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			11	24					0	0	0.008291	0	0
CSMD3	114788	broad.mit.edu	37	8	114185958	114185958	+	Silent	SNP	G	G	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr8:114185958G>A	uc003ynu.2	-	4	861	c.702C>T	c.(700-702)ATC>ATT	p.I234I	CSMD3_uc003ynt.2_Silent_p.I194I|CSMD3_uc011lhx.1_Silent_p.I234I|CSMD3_uc010mcx.1_Silent_p.I234I	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	234	Extracellular (Potential).|Sushi 1.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						TACCTCTACAGATAGGAACAG	0.408			NA								HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			23	41					0	0	0.00278	0	0
TRPS1	7227	broad.mit.edu	37	8	116426548	116426548	+	Missense_Mutation	SNP	C	C	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr8:116426548C>A	uc003ynz.2	-	6	4008	c.3549G>T	c.(3547-3549)GAG>GAT	p.E1183D	TRPS1_uc011lhy.1_Missense_Mutation_p.E1187D|TRPS1_uc003yny.2_Missense_Mutation_p.E1196D|TRPS1_uc010mcy.2_Missense_Mutation_p.E1183D	NM_014112	NP_054831	Q9UHF7	TRPS1_HUMAN	zinc finger transcription factor TRPS1	1183	Transcriptional repressor domain (By similarity).|Mediates interaction with RNF4 (By similarity).				negative regulation of transcription from RNA polymerase II promoter|NLS-bearing substrate import into nucleus|regulation of chondrocyte differentiation|skeletal system development|transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)|skin(2)|pancreas(1)|lung(1)|kidney(1)	7	all_cancers(13;5.44e-23)|all_epithelial(1;2.14e-27)|Lung NSC(37;2.55e-05)|Ovarian(258;0.0219)		Epithelial(1;9.78e-37)|all cancers(1;3.14e-31)|BRCA - Breast invasive adenocarcinoma(1;2.56e-12)			CCTTCGTTTTCTCCTTGGAGG	0.413			NA							Langer-Giedion_syndrome				12	46					7.03913e-09	8.48905e-09	0.013537	1	0
TRPS1	7227	broad.mit.edu	37	8	116599299	116599299	+	Missense_Mutation	SNP	C	C	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr8:116599299C>A	uc003ynz.2	-	4	3049	c.2590G>T	c.(2590-2592)GGG>TGG	p.G864W	TRPS1_uc011lhy.1_Missense_Mutation_p.G868W|TRPS1_uc003yny.2_Missense_Mutation_p.G877W|TRPS1_uc010mcy.2_Missense_Mutation_p.G864W	NM_014112	NP_054831	Q9UHF7	TRPS1_HUMAN	zinc finger transcription factor TRPS1	864					negative regulation of transcription from RNA polymerase II promoter|NLS-bearing substrate import into nucleus|regulation of chondrocyte differentiation|skeletal system development|transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)|skin(2)|pancreas(1)|lung(1)|kidney(1)	7	all_cancers(13;5.44e-23)|all_epithelial(1;2.14e-27)|Lung NSC(37;2.55e-05)|Ovarian(258;0.0219)		Epithelial(1;9.78e-37)|all cancers(1;3.14e-31)|BRCA - Breast invasive adenocarcinoma(1;2.56e-12)			GGGAGGGCCCCAGACTTCTCT	0.547			NA							Langer-Giedion_syndrome				24	72					1.9806e-07	2.31548e-07	0.014323	1	0
COL14A1	7373	broad.mit.edu	37	8	121295936	121295936	+	Missense_Mutation	SNP	C	C	G			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr8:121295936C>G	uc003yox.2	+	32	4151	c.3886C>G	c.(3886-3888)CCT>GCT	p.P1296A	COL14A1_uc003yoz.2_Missense_Mutation_p.P261A	NM_021110	NP_066933	Q05707	COEA1_HUMAN	collagen, type XIV, alpha 1 precursor	1296	Nonhelical region (NC4).|TSP N-terminal.				cell-cell adhesion|collagen fibril organization	collagen type XIV|extracellular space	collagen binding|extracellular matrix structural constituent|protein binding, bridging			ovary(4)|kidney(4)|skin(2)|pancreas(1)|central_nervous_system(1)	12	Lung NSC(37;6.52e-07)|Ovarian(258;0.00769)|Hepatocellular(40;0.161)		OV - Ovarian serous cystadenocarcinoma(1;6.47e-38)|STAD - Stomach adenocarcinoma(47;0.00503)			CCGGATTCTTCCTGACACTCC	0.388			NA											15	67					0	0	0.004007	0	0
WDR67	93594	broad.mit.edu	37	8	124113096	124113096	+	Missense_Mutation	SNP	A	A	C			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr8:124113096A>C	uc003ypp.1	+	7	971	c.881A>C	c.(880-882)CAG>CCG	p.Q294P	WDR67_uc011lig.1_Missense_Mutation_p.Q294P|WDR67_uc011lih.1_Missense_Mutation_p.Q184P|WDR67_uc003ypq.1_RNA|WDR67_uc003yps.1_Missense_Mutation_p.Q7P|WDR67_uc003ypo.1_Missense_Mutation_p.Q294P|WDR67_uc003ypr.2_RNA	NM_145647	NP_663622	Q96DN5	WDR67_HUMAN	WD repeat domain 67 isoform 1	294						centrosome	Rab GTPase activator activity			skin(1)	1	Lung NSC(37;7e-10)|Ovarian(258;0.0205)		STAD - Stomach adenocarcinoma(47;0.00527)			ATCAATATGCAGACTTGTAAA	0.353			NA											8	26					0	0	0.00308	0	0
FAM83A	84985	broad.mit.edu	37	8	124219708	124219708	+	Missense_Mutation	SNP	A	A	C			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr8:124219708A>C	uc003ypv.2	+	5	3099	c.1085A>C	c.(1084-1086)CAC>CCC	p.H362P	FAM83A_uc003ypw.2_Intron|FAM83A_uc003ypy.2_Intron|FAM83A_uc003ypx.2_Missense_Mutation_p.H362P|FAM83A_uc003ypz.2_Intron	NM_032899	NP_116288	Q86UY5	FA83A_HUMAN	hypothetical protein LOC84985 isoform a	362	Pro-rich.									ovary(3)|skin(1)	4	Lung NSC(37;1.55e-09)|Ovarian(258;0.0205)		STAD - Stomach adenocarcinoma(47;0.00527)			GCGGCCCCACACCCGCCTCCA	0.766			NA											5	19					0	0	0.00308	0	0
ADCY8	114	broad.mit.edu	37	8	131812783	131812783	+	Silent	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr8:131812783C>T	uc003ytd.3	-	15	3205	c.2949G>A	c.(2947-2949)GTG>GTA	p.V983V	ADCY8_uc010mds.2_Silent_p.V852V	NM_001115	NP_001106	P40145	ADCY8_HUMAN	adenylate cyclase 8	983	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|membrane fraction|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|metal ion binding			skin(4)|large_intestine(1)|central_nervous_system(1)	6	Esophageal squamous(12;0.00693)|Ovarian(258;0.00707)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000538)			AGGCAAACATCACCCCAACAG	0.493			NA								HNSCC(32;0.087)			17	94					0	0	0.004007	0	0
ADCY8	114	broad.mit.edu	37	8	131955633	131955633	+	Silent	SNP	G	G	C			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr8:131955633G>C	uc003ytd.3	-	4	1573	c.1317C>G	c.(1315-1317)CTC>CTG	p.L439L	ADCY8_uc010mds.2_Silent_p.L439L	NM_001115	NP_001106	P40145	ADCY8_HUMAN	adenylate cyclase 8	439	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|membrane fraction|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|metal ion binding			skin(4)|large_intestine(1)|central_nervous_system(1)	6	Esophageal squamous(12;0.00693)|Ovarian(258;0.00707)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000538)			AGAGCTCGTTGAGCATCCTGA	0.473			NA								HNSCC(32;0.087)			4	19					0	0	0.001168	0	0
DENND3	22898	broad.mit.edu	37	8	142190928	142190928	+	Silent	SNP	G	G	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr8:142190928G>T	uc003yvy.2	+	17	2957	c.2679G>T	c.(2677-2679)GCG>GCT	p.A893A	DENND3_uc010mep.2_Silent_p.A854A	NM_014957	NP_055772	A2RUS2	DEND3_HUMAN	DENN/MADD domain containing 3	893										ovary(1)	1	all_cancers(97;7.36e-15)|all_epithelial(106;2.33e-13)|Lung NSC(106;1.23e-05)|all_lung(105;1.75e-05)|Ovarian(258;0.01)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.105)			TCCCACAAGCGGTGGACGTGC	0.577			NA											21	60					1.01871e-10	1.25994e-10	0.008871	1	0
BAI1	575	broad.mit.edu	37	8	143623974	143623974	+	Missense_Mutation	SNP	A	A	G			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr8:143623974A>G	uc003ywm.2	+	27	4562	c.4379A>G	c.(4378-4380)GAG>GGG	p.E1460G		NM_001702	NP_001693	O14514	BAI1_HUMAN	brain-specific angiogenesis inhibitor 1	1460	Cytoplasmic (Potential).|Necessary for interaction with MAGI1.				axonogenesis|cell adhesion|negative regulation of angiogenesis|negative regulation of cell proliferation|neuropeptide signaling pathway|peripheral nervous system development	cell-cell junction|integral to plasma membrane	G-protein coupled receptor activity|protein binding			lung(3)|ovary(2)|breast(1)|central_nervous_system(1)|pancreas(1)	8	all_cancers(97;2.84e-12)|all_epithelial(106;5.91e-09)|Lung NSC(106;0.000322)|all_lung(105;0.000616)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0315)|Acute lymphoblastic leukemia(118;0.155)					ACCAAGAACGAGAATGTCGCC	0.677			NA											2	3					0	0	0.004672	0	0
LY6K	54742	broad.mit.edu	37	8	143784660	143784660	+	Silent	SNP	A	A	G			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr8:143784660A>G	uc011ljv.1	+	3	786	c.369A>G	c.(367-369)TTA>TTG	p.L123L	LY6K_uc011ljw.1_3'UTR|LY6K_uc011ljx.1_3'UTR	NM_017527	NP_059997	Q17RY6	LY6K_HUMAN	lymphocyte antigen 6 complex, locus K isoform 1	123	UPAR/Ly6.					anchored to membrane|cytoplasm|extracellular region|nucleolus|plasma membrane				central_nervous_system(1)	1	all_cancers(97;3.96e-12)|all_epithelial(106;1.19e-08)|Lung NSC(106;0.000413)|all_lung(105;0.00106)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)					ACTGCAATTTAGAGGGGCCAC	0.532			NA											11	79					0	0	0.008291	0	0
GML	2765	broad.mit.edu	37	8	143928027	143928027	+	Missense_Mutation	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr8:143928027C>T	uc003yxg.2	+	4	488	c.398C>T	c.(397-399)CCA>CTA	p.P133L		NM_002066	NP_002057	Q99445	GML_HUMAN	glycosylphosphatidylinositol anchored molecule	133	UPAR/Ly6.				apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|negative regulation of cell proliferation	anchored to membrane|extrinsic to membrane|plasma membrane				central_nervous_system(2)	2	all_cancers(97;4.26e-11)|all_epithelial(106;1.85e-08)|Lung NSC(106;0.000274)|all_lung(105;0.000755)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)					GAGGAGCTTCCAGAAGGAACT	0.463			NA											14	46					0	0	0.001855	0	0
CYP11B1	1584	broad.mit.edu	37	8	143955876	143955876	+	Silent	SNP	T	T	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr8:143955876T>A	uc003yxi.2	-	9	1432	c.1425A>T	c.(1423-1425)ACA>ACT	p.T475T	CYP11B1_uc010mex.2_Silent_p.T174T|CYP11B1_uc003yxh.2_Silent_p.T125T|CYP11B1_uc003yxj.2_Silent_p.T409T|CYP11B1_uc010mey.2_Silent_p.T546T	NM_000497	NP_000488	P15538	C11B1_HUMAN	cytochrome P450, family 11, subfamily B,	475					aldosterone biosynthetic process|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|glucose homeostasis|immune response|regulation of blood pressure|response to stress|xenobiotic metabolic process	mitochondrial inner membrane	electron carrier activity|steroid 11-beta-monooxygenase activity			ovary(3)	3	all_cancers(97;4.74e-11)|all_epithelial(106;2.06e-08)|Lung NSC(106;0.000228)|all_lung(105;0.000633)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)				Mitotane(DB00648)	CTTGGGTTAGTGTCTCCACCT	0.542			NA							Familial_Hyperaldosteronism_type_I				29	66					0	0	0.012213	0	0
CYP11B2	1585	broad.mit.edu	37	8	143995833	143995833	+	Silent	SNP	A	A	G			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr8:143995833A>G	uc003yxk.1	-	5	804	c.801T>C	c.(799-801)GGT>GGC	p.G267G		NM_000498	NP_000489	P19099	C11B2_HUMAN	cytochrome P450, family 11, subfamily B,	267					aldosterone biosynthetic process|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|potassium ion homeostasis|regulation of blood volume by renal aldosterone|sodium ion homeostasis|xenobiotic metabolic process		corticosterone 18-monooxygenase activity|electron carrier activity|steroid 11-beta-monooxygenase activity				0	all_cancers(97;5.56e-11)|all_epithelial(106;2.49e-08)|Lung NSC(106;0.000228)|all_lung(105;0.000633)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)				Candesartan(DB00796)|Metyrapone(DB01011)	TACAGTTGTCACCTGTCCAGG	0.577			NA							Familial_Hyperaldosteronism_type_I				7	23					0	0	0.00308	0	0
C8orf31	286122	broad.mit.edu	37	8	144124453	144124453	+	Nonsense_Mutation	SNP	C	C	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr8:144124453C>A	uc003yxp.1	+	2	387	c.35C>A	c.(34-36)TCA>TAA	p.S12*	C8orf31_uc003yxq.1_RNA|C8orf31_uc003yxr.1_Intron	NM_173687	NP_775958	Q8N9H6	CH031_HUMAN	hypothetical protein LOC286122	12										ovary(1)	1	all_cancers(97;1.89e-10)|all_epithelial(106;8.73e-09)|Lung NSC(106;0.000161)|all_lung(105;0.000447)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)					TCCTGCAATTCAGTGAGGCAG	0.607			NA											21	68					4.96729e-08	5.87338e-08	0.008871	1	0
ZC3H3	23144	broad.mit.edu	37	8	144522323	144522323	+	Silent	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr8:144522323C>T	uc003yyd.2	-	11	2732	c.2703G>A	c.(2701-2703)GCG>GCA	p.A901A		NM_015117	NP_055932	Q8IXZ2	ZC3H3_HUMAN	zinc finger CCCH-type containing 3	901					mRNA polyadenylation|poly(A)+ mRNA export from nucleus|regulation of mRNA export from nucleus	nucleus	nucleic acid binding|zinc ion binding			skin(1)	1	all_cancers(97;8.64e-11)|all_epithelial(106;6.43e-09)|Lung NSC(106;0.000202)|all_lung(105;0.000548)|Ovarian(258;0.0212)|Acute lymphoblastic leukemia(118;0.155)		Colorectal(110;0.107)|BRCA - Breast invasive adenocarcinoma(115;0.107)			TGTTGGAGCACGCTGCTGCTA	0.557			NA											3	11					0	0	0.009096	0	0
OPLAH	26873	broad.mit.edu	37	8	145108219	145108219	+	Missense_Mutation	SNP	C	C	G			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr8:145108219C>G	uc003zar.3	-	20	2846	c.2764G>C	c.(2764-2766)GAC>CAC	p.D922H	OPLAH_uc003zas.1_Missense_Mutation_p.G196A	NM_017570	NP_060040	O14841	OPLA_HUMAN	5-oxoprolinase (ATP-hydrolysing)	922							5-oxoprolinase (ATP-hydrolyzing) activity|ATP binding				0	all_cancers(97;1.06e-10)|all_epithelial(106;1.5e-09)|Lung NSC(106;5.89e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;6.79e-41)|Epithelial(56;1.02e-39)|all cancers(56;2.24e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)		L-Glutamic Acid(DB00142)	GCACGGAGGTCCGACAGGTTG	0.652			NA											13	37					0	0	0.013537	0	0
ZNF16	7564	broad.mit.edu	37	8	146157923	146157923	+	Missense_Mutation	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr8:146157923C>T	uc003zet.2	-	4	437	c.250G>A	c.(250-252)GAA>AAA	p.E84K	ZNF16_uc003zeu.2_Missense_Mutation_p.E84K	NM_001029976	NP_001025147	P17020	ZNF16_HUMAN	zinc finger protein 16	84					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(5)	5	all_cancers(97;8.72e-12)|all_epithelial(106;1.07e-10)|Lung NSC(106;7.18e-05)|all_lung(105;0.00021)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)	Acute lymphoblastic leukemia(644;0.136)	Epithelial(56;3.45e-38)|all cancers(56;3.04e-33)|BRCA - Breast invasive adenocarcinoma(115;0.0424)|Colorectal(110;0.055)	GBM - Glioblastoma multiforme(99;0.02)|KIRC - Kidney renal clear cell carcinoma(644;0.0486)		TCCAAATCTTCATGAATGTCT	0.423			NA											11	67					0	0	0.008291	0	0
DOCK8	81704	broad.mit.edu	37	9	286583	286583	+	Silent	SNP	G	G	C			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr9:286583G>C	uc003zgf.2	+	3	391	c.279G>C	c.(277-279)GTG>GTC	p.V93V	DOCK8_uc011lls.1_Silent_p.V93V|DOCK8_uc010mgu.2_5'UTR|DOCK8_uc010mgv.2_Silent_p.V25V|DOCK8_uc010mgt.2_Silent_p.V25V|DOCK8_uc003zgg.2_Silent_p.V25V|DOCK8_uc003zgh.2_RNA	NM_203447	NP_982272	Q8NF50	DOCK8_HUMAN	dedicator of cytokinesis 8	93					blood coagulation	cytosol	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			ovary(3)|central_nervous_system(3)	6		all_cancers(5;2.13e-17)|all_epithelial(5;2.15e-12)|all_lung(10;6.69e-11)|Lung NSC(10;1.08e-10)|Acute lymphoblastic leukemia(5;0.000242)|all_hematologic(5;0.00317)|Breast(48;0.0151)|Prostate(43;0.128)		all cancers(5;9.3e-07)|GBM - Glioblastoma multiforme(5;2.41e-06)|Epithelial(6;0.00557)|Lung(218;0.00942)		ACTTGGACGTGGTGTTCACGC	0.493			NA											16	13					0	0	0.00499	0	0
DMRT2	10655	broad.mit.edu	37	9	1056458	1056458	+	Missense_Mutation	SNP	C	C	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr9:1056458C>A	uc003zha.2	+	4	1071	c.871C>A	c.(871-873)CCA>ACA	p.P291T	DMRT2_uc003zgx.3_Missense_Mutation_p.P58T|DMRT2_uc010mgz.2_Missense_Mutation_p.P58T|DMRT2_uc003zgy.3_Missense_Mutation_p.P135T|DMRT2_uc003zhb.3_3'UTR|DMRT2_uc011llt.1_3'UTR|DMRT2_uc011llu.1_3'UTR|DMRT2_uc011llv.1_Missense_Mutation_p.P291T	NM_181872	NP_870987	Q9Y5R5	DMRT2_HUMAN	doublesex and mab-3 related transcription factor	291					male gonad development|sex determination	nucleus	DNA binding|metal ion binding|sequence-specific DNA binding transcription factor activity				0		all_lung(10;1.49e-09)|Lung NSC(10;1.86e-09)		Lung(218;0.0195)|GBM - Glioblastoma multiforme(50;0.0388)		CAGCCCCAGCCCAGTGGAACC	0.483			NA											13	49					1.61879e-10	1.99532e-10	0.013537	1	0
KIAA1432	57589	broad.mit.edu	37	9	5743005	5743005	+	Silent	SNP	A	A	C			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr9:5743005A>C	uc003zji.2	+	8	894	c.801A>C	c.(799-801)GGA>GGC	p.G267G	KIAA1432_uc003zjh.2_Silent_p.G267G|KIAA1432_uc003zjl.3_Silent_p.G267G|KIAA1432_uc003zjj.1_5'UTR	NM_020829	NP_065880	Q4ADV7	RIC1_HUMAN	connexin 43-interacting protein 150 isoform a	346						integral to membrane					0		Acute lymphoblastic leukemia(23;0.154)		GBM - Glioblastoma multiforme(50;0.000525)|Lung(218;0.122)		CACTTGGAGGAGATTTTGCGT	0.373			NA											4	16					0	0	0.000602	0	0
FAM154A	158297	broad.mit.edu	37	9	18941665	18941665	+	Missense_Mutation	SNP	C	C	T	rs144484870	byFrequency	TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr9:18941665C>T	uc003zni.1	-	3	669	c.391G>A	c.(391-393)GAC>AAC	p.D131N	FAM154A_uc010mip.1_Intron	NM_153707	NP_714918	Q8IYX7	F154A_HUMAN	hypothetical protein LOC158297	131										pancreas(1)	1				GBM - Glioblastoma multiforme(50;6.53e-16)		TCCATCTTGTCGCTACATGGA	0.493			NA											20	33					0	0	0.010504	0	0
SLC24A2	25769	broad.mit.edu	37	9	19785946	19785946	+	Missense_Mutation	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr9:19785946C>T	uc003zoa.1	-	1	981	c.919G>A	c.(919-921)GCC>ACC	p.A307T	SLC24A2_uc003zob.1_Missense_Mutation_p.A307T	NM_020344	NP_065077	Q9UI40	NCKX2_HUMAN	solute carrier family 24	307	Cytoplasmic (Potential).				visual perception	integral to membrane|plasma membrane	calcium, potassium:sodium antiporter activity|symporter activity			ovary(3)	3				GBM - Glioblastoma multiforme(1;1.67e-55)|Lung(42;0.0443)		TTTGCTTGGGCTTCTGGTGCT	0.378			NA											13	39					0	0	0.001855	0	0
CDKN2A	1029	broad.mit.edu	37	9	21971203	21971203	+	Missense_Mutation	SNP	A	A	C			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr9:21971203A>C	uc003zpk.2	-	2	367	c.155T>G	c.(154-156)ATG>AGG	p.M52R	MTAP_uc003zpi.1_Intron|CDKN2A_uc003zpj.2_3'UTR|CDKN2A_uc010miu.2_RNA|CDKN2A_uc003zpl.2_Missense_Mutation_p.H107Q	NM_000077	NP_000068	P42771	CD2A1_HUMAN	cyclin-dependent kinase inhibitor 2A isoform 1	52	ANK 2.				cell cycle arrest|cell cycle checkpoint|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of cell-matrix adhesion|negative regulation of cyclin-dependent protein kinase activity|negative regulation of NF-kappaB transcription factor activity|positive regulation of macrophage apoptosis|positive regulation of smooth muscle cell apoptosis|Ras protein signal transduction|replicative senescence	cytosol|nucleus	cyclin-dependent protein kinase inhibitor activity|NF-kappaB binding|protein binding|protein binding|protein kinase binding	p.0?(1112)|p.?(14)|p.M52K(4)|p.M52I(3)|p.M52fs*68(2)|p.M52fs*2(1)|p.V28_V51del(1)|p.M52L(1)		haematopoietic_and_lymphoid_tissue(647)|skin(419)|upper_aerodigestive_tract(414)|central_nervous_system(381)|lung(325)|pancreas(244)|oesophagus(230)|urinary_tract(225)|pleura(94)|liver(91)|soft_tissue(79)|bone(77)|ovary(76)|biliary_tract(71)|stomach(46)|breast(46)|kidney(39)|NS(28)|thyroid(24)|cervix(23)|meninges(18)|genital_tract(15)|endometrium(13)|prostate(11)|autonomic_ganglia(10)|salivary_gland(10)|large_intestine(9)|adrenal_gland(6)|eye(4)|vulva(2)|small_intestine(1)	3678		all_cancers(5;0)|Acute lymphoblastic leukemia(3;0)|all_hematologic(3;0)|all_epithelial(2;2.37e-290)|Lung NSC(2;1.26e-139)|all_lung(2;4.48e-131)|Glioma(2;3.26e-60)|all_neural(2;2.1e-52)|Renal(3;1.07e-46)|Esophageal squamous(3;3.83e-46)|Melanoma(2;2.74e-34)|Breast(3;1.14e-11)|Ovarian(3;0.000128)|Hepatocellular(5;0.00162)|Colorectal(97;0.172)		all cancers(2;0)|GBM - Glioblastoma multiforme(3;0)|Lung(2;4.07e-74)|Epithelial(2;1.08e-61)|LUSC - Lung squamous cell carcinoma(2;3.82e-48)|LUAD - Lung adenocarcinoma(2;4.56e-26)|OV - Ovarian serous cystadenocarcinoma(39;7.64e-10)|BRCA - Breast invasive adenocarcinoma(2;5.01e-09)|STAD - Stomach adenocarcinoma(4;4.63e-07)|Kidney(2;5.79e-07)|KIRC - Kidney renal clear cell carcinoma(2;7.27e-07)|COAD - Colon adenocarcinoma(8;5.15e-05)		GCCCATCATCATGACCTGCCA	0.672			17							Uveal_Melanoma_Familial|Familial_Malignant_Melanoma_and_Tumors_of_the_Nervous_System|Hereditary_Melanoma	HNSCC(2;<9.43e_08)|TSP Lung(5;3.83e-07)			10	9					0	0	0.010729	0	0
ELAVL2	1993	broad.mit.edu	37	9	23762245	23762245	+	Translation_Start_Site	SNP	C	C	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr9:23762245C>A	uc003zpu.2	-	2	263	c.-12G>T	c.(-14--10)CAGGT>CATGT		ELAVL2_uc003zps.2_Translation_Start_Site|ELAVL2_uc003zpt.2_Translation_Start_Site|ELAVL2_uc003zpv.2_Splice_Site|ELAVL2_uc003zpw.2_Splice_Site	NM_004432	NP_004423	Q12926	ELAV2_HUMAN	ELAV (embryonic lethal, abnormal vision,						regulation of transcription, DNA-dependent		mRNA 3'-UTR binding|nucleotide binding|protein binding			ovary(2)|central_nervous_system(1)	3				GBM - Glioblastoma multiforme(1;2.18e-156)|Lung(42;2.15e-28)|LUSC - Lung squamous cell carcinoma(38;1.02e-19)		CAGCAATTACCTGCTAAAAAC	0.393			NA											21	30					4.63292e-17	6.16591e-17	0.008871	1	0
UBAP2	55833	broad.mit.edu	37	9	33927814	33927814	+	Silent	SNP	G	G	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr9:33927814G>A	uc003ztq.1	-	20	2465	c.2352C>T	c.(2350-2352)GCC>GCT	p.A784A	UBAP2_uc011loc.1_Silent_p.A693A|UBAP2_uc011lod.1_Silent_p.A517A|UBAP2_uc011loe.1_Silent_p.A539A|UBAP2_uc011lof.1_Silent_p.A709A|UBAP2_uc011log.1_3'UTR|UBAP2_uc003ztn.1_Silent_p.A23A|UBAP2_uc003zto.1_Silent_p.A23A|UBAP2_uc003ztp.1_Silent_p.A23A	NM_018449	NP_060919	Q5T6F2	UBAP2_HUMAN	ubiquitin associated protein 2	784										ovary(3)	3			LUSC - Lung squamous cell carcinoma(29;0.00575)	GBM - Glioblastoma multiforme(74;0.168)		CCAAGGGCGCGGCCCTGCTAC	0.652			NA											4	98					0	0	0.000602	0	0
UNC13B	10497	broad.mit.edu	37	9	35370326	35370326	+	Missense_Mutation	SNP	G	G	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr9:35370326G>T	uc003zwq.2	+	12	1518	c.1226G>T	c.(1225-1227)GGG>GTG	p.G409V	UNC13B_uc010mkl.1_Missense_Mutation_p.G417C|UNC13B_uc003zwr.2_Missense_Mutation_p.G409V	NM_006377	NP_006368	O14795	UN13B_HUMAN	UNC13 (C. elegans)-like	409					excretion|induction of apoptosis|intracellular signal transduction	cell junction|Golgi apparatus|synapse	metal ion binding|receptor activity			ovary(3)|large_intestine(1)|skin(1)	5	all_epithelial(49;0.212)		LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00778)|STAD - Stomach adenocarcinoma(86;0.194)			CCAGCCGGAGGGCTCTATGGC	0.512			NA											12	28					5.16669e-11	6.42297e-11	0.010729	1	0
TLN1	7094	broad.mit.edu	37	9	35719611	35719611	+	Nonsense_Mutation	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr9:35719611C>T	uc003zxt.2	-	15	1946	c.1592G>A	c.(1591-1593)TGG>TAG	p.W531*		NM_006289	NP_006280	Q9Y490	TLN1_HUMAN	talin 1	531					axon guidance|cell adhesion|cell-cell junction assembly|cellular component movement|cytoskeletal anchoring at plasma membrane|muscle contraction|platelet activation|platelet degranulation	actin cytoskeleton|centrosome|cytosol|extracellular region|focal adhesion|intracellular membrane-bounded organelle|ruffle membrane	actin binding|insulin receptor binding|LIM domain binding|structural constituent of cytoskeleton|vinculin binding			lung(7)|breast(3)|ovary(2)|central_nervous_system(1)	13	all_epithelial(49;0.167)		Lung(28;0.00276)|LUSC - Lung squamous cell carcinoma(32;0.00418)|STAD - Stomach adenocarcinoma(86;0.194)			GTTTTTACGCCAGGCCTTAGA	0.512			NA											17	76					0	0	0.004007	0	0
POLR1E	64425	broad.mit.edu	37	9	37486630	37486630	+	Missense_Mutation	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr9:37486630C>T	uc003zzz.1	+	1	481	c.193C>T	c.(193-195)CCA>TCA	p.P65S	POLR1E_uc011lqj.1_Intron|POLR1E_uc003zzy.1_Intron|POLR1E_uc011lqk.1_Intron	NM_022490	NP_071935	Q9GZS1	RPA49_HUMAN	RNA polymerase I associated factor 53	65					rRNA transcription	cell junction|cytoplasm|nucleolus	DNA binding|DNA-directed RNA polymerase activity|protein binding				0				GBM - Glioblastoma multiforme(29;0.00851)|Lung(182;0.229)		CAGTCTAGTCCCACCgtacat	0.498	Ovarian(116;843 1620 18506 32459 34463)		NA											15	42					0	0	0.003163	0	0
TRPM3	80036	broad.mit.edu	37	9	73213554	73213554	+	Silent	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr9:73213554C>T	uc004aid.2	-	20	3037	c.2793G>A	c.(2791-2793)CAG>CAA	p.Q931Q	TRPM3_uc004ahu.2_Silent_p.Q761Q|TRPM3_uc004ahv.2_Silent_p.Q733Q|TRPM3_uc004ahw.2_Silent_p.Q803Q|TRPM3_uc004ahx.2_Silent_p.Q790Q|TRPM3_uc004ahy.2_Silent_p.Q793Q|TRPM3_uc004ahz.2_Silent_p.Q780Q|TRPM3_uc004aia.2_Silent_p.Q778Q|TRPM3_uc004aib.2_Silent_p.Q768Q|TRPM3_uc004aic.2_Silent_p.Q931Q	NM_001007471	NP_001007472	Q9HCF6	TRPM3_HUMAN	transient receptor potential cation channel,	956	Cytoplasmic (Potential).					integral to membrane	calcium channel activity			ovary(3)|pancreas(2)|central_nervous_system(2)|skin(2)	9						CCTTCACTTTCTGTAGCAACT	0.493			NA											14	58					0	0	0.00245	0	0
FLJ43950	347127	broad.mit.edu	37	9	84530475	84530475	+	Silent	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr9:84530475C>T	uc011lst.1	+	4	497	c.396C>T	c.(394-396)TCC>TCT	p.S132S		NR_026851				SubName: Full=cDNA FLJ43950 fis, clone TESTI4015293, moderately similar to FAM75-like protein;												0						CCTTTGTGTCCCCTTTGGCTT	0.532			NA											11	12					0	0	0.013537	0	0
FRMD3	257019	broad.mit.edu	37	9	85863297	85863297	+	Missense_Mutation	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr9:85863297C>T	uc004ams.1	-	14	1532	c.1330G>A	c.(1330-1332)GAA>AAA	p.E444K	FRMD3_uc004amr.1_Missense_Mutation_p.E430K|FRMD3_uc004amq.1_Missense_Mutation_p.E101K	NM_174938	NP_777598	A2A2Y4	FRMD3_HUMAN	FERM domain containing 3	444						cytoplasm|cytoskeleton|extrinsic to membrane|integral to membrane	cytoskeletal protein binding			ovary(1)|central_nervous_system(1)	2						TACACTAGTTCAGAGATGGTT	0.493			NA											20	41					0	0	0.007413	0	0
SLC28A3	64078	broad.mit.edu	37	9	86902971	86902971	+	Missense_Mutation	SNP	C	C	A	rs148078245	byFrequency	TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr9:86902971C>A	uc010mpz.2	-	12	1397	c.1272G>T	c.(1270-1272)ATG>ATT	p.M424I	SLC28A3_uc011lsy.1_Missense_Mutation_p.M355I|SLC28A3_uc004anu.1_Missense_Mutation_p.M424I	NM_022127	NP_071410	Q9HAS3	S28A3_HUMAN	concentrative Na+-nucleoside cotransporter	424	Extracellular (Potential).				nucleobase, nucleoside and nucleotide metabolic process	integral to membrane|plasma membrane	nucleoside binding			upper_aerodigestive_tract(1)|ovary(1)|pancreas(1)|skin(1)	4						ACCCACTTTCCATTTTCATGG	0.458	Ovarian(106;425 1539 34835 42413 43572)		NA											34	43					4.65686e-17	6.19209e-17	0.003755	1	0
FAM75C1	441452	broad.mit.edu	37	9	90535364	90535364	+	Missense_Mutation	SNP	C	C	G			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr9:90535364C>G	uc010mqi.2	+	4	571	c.542C>G	c.(541-543)CCA>CGA	p.P181R	FAM75C1_uc004apq.3_Missense_Mutation_p.P164R	NM_001145124	NP_001138596			family with sequence similarity 75, member C1												0						GCCTCCACCCCACCACCAGGC	0.607			NA											71	110					0	0	0.01441	0	0
SYK	6850	broad.mit.edu	37	9	93650153	93650153	+	Nonsense_Mutation	SNP	T	T	G			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr9:93650153T>G	uc004aqz.2	+	12	1909	c.1704T>G	c.(1702-1704)TAT>TAG	p.Y568*	SYK_uc004ara.2_Nonsense_Mutation_p.Y545*|SYK_uc004arb.2_Nonsense_Mutation_p.Y545*|SYK_uc004arc.2_Nonsense_Mutation_p.Y568*|SYK_uc011ltr.1_RNA|SYK_uc011lts.1_RNA|SYK_uc011ltt.1_RNA	NM_003177	NP_003168	P43405	KSYK_HUMAN	spleen tyrosine kinase isoform 1	568	Protein kinase.				cell proliferation|integrin-mediated signaling pathway|interspecies interaction between organisms|leukocyte cell-cell adhesion|neutrophil chemotaxis|organ morphogenesis|platelet activation|protein complex assembly	cytosol|T cell receptor complex	ATP binding|integrin binding|non-membrane spanning protein tyrosine kinase activity			lung(2)|stomach(1)|ovary(1)|skin(1)	5						CATTCTCCTATGGGCAGAAGC	0.468			NA	T	ETV6|ITK	MDS|peripheral T-cell lymphoma								8	98					0	0	0.00245	0	0
FGD3	89846	broad.mit.edu	37	9	95773525	95773525	+	Missense_Mutation	SNP	A	A	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr9:95773525A>T	uc004asw.2	+	8	1634	c.1006A>T	c.(1006-1008)AAC>TAC	p.N336Y	FGD3_uc004asx.2_Missense_Mutation_p.N336Y|FGD3_uc004asz.2_Missense_Mutation_p.N336Y|FGD3_uc004ata.2_Missense_Mutation_p.N139Y	NM_001083536	NP_001077005	Q5JSP0	FGD3_HUMAN	FYVE, RhoGEF and PH domain containing 3	336	DH.				actin cytoskeleton organization|apoptosis|filopodium assembly|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Cdc42 GTPase activity|regulation of cell shape|small GTPase mediated signal transduction	cytoskeleton|cytosol|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			ovary(1)|breast(1)	2						CACAGCCGCCAACCACTCCAA	0.637			NA											4	79					0	0	0.009096	0	0
WNK2	65268	broad.mit.edu	37	9	96025976	96025976	+	Missense_Mutation	SNP	G	G	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr9:96025976G>T	uc004ati.1	+	14	3539	c.3539G>T	c.(3538-3540)CGG>CTG	p.R1180L	WNK2_uc011lud.1_Missense_Mutation_p.R1180L|WNK2_uc004atj.2_Missense_Mutation_p.R1180L|WNK2_uc004atk.2_Missense_Mutation_p.R817L	NM_006648	NP_006639	Q9Y3S1	WNK2_HUMAN	WNK lysine deficient protein kinase 2	1180					intracellular protein kinase cascade		ATP binding|protein binding|protein serine/threonine kinase activity			lung(4)|stomach(3)|ovary(2)|large_intestine(1)|central_nervous_system(1)|breast(1)	12						GCGCGCTCCCGGCAGGAGAGG	0.537			NA											3	3					0.004672	0.004818	0.004672	1	0
PTCH1	5727	broad.mit.edu	37	9	98242849	98242849	+	Missense_Mutation	SNP	C	C	G			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr9:98242849C>G	uc004avk.3	-	6	956	c.768G>C	c.(766-768)TGG>TGC	p.W256C	PTCH1_uc010mro.2_Missense_Mutation_p.W105C|PTCH1_uc010mrp.2_Missense_Mutation_p.W105C|PTCH1_uc010mrq.2_Missense_Mutation_p.W105C|PTCH1_uc004avl.3_Missense_Mutation_p.W105C|PTCH1_uc010mrr.2_Missense_Mutation_p.W190C|PTCH1_uc004avm.3_Missense_Mutation_p.W255C|PTCH1_uc010mrs.1_5'UTR|PTCH1_uc010mrt.1_RNA|PTCH1_uc010mru.1_RNA	NM_000264	NP_000255	Q13635	PTC1_HUMAN	patched isoform L	256	Extracellular (Potential).				embryonic limb morphogenesis|negative regulation of multicellular organism growth|protein processing|regulation of smoothened signaling pathway|smoothened signaling pathway	integral to plasma membrane	hedgehog receptor activity	p.W256*(1)		skin(242)|central_nervous_system(72)|bone(33)|upper_aerodigestive_tract(11)|lung(6)|large_intestine(4)|breast(4)|oesophagus(3)|ovary(3)|vulva(1)	379		Medulloblastoma(1;7.87e-06)|all_neural(1;0.000555)|Acute lymphoblastic leukemia(62;0.136)				CGAAGTTTGTCCACCGCAAAG	0.458			NA							Basal_Cell_Nevus_syndrome				14	40					0	0	0.00245	0	0
HABP4	22927	broad.mit.edu	37	9	99227767	99227767	+	Missense_Mutation	SNP	G	G	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr9:99227767G>T	uc010msg.2	+	3	809	c.661G>T	c.(661-663)GGG>TGG	p.G221W	HABP4_uc010msh.2_Intron	NM_014282	NP_055097	Q5JVS0	HABP4_HUMAN	hyaluronan binding protein 4	221					platelet activation|platelet degranulation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|extracellular region|nucleus	protein binding			ovary(1)	1		Acute lymphoblastic leukemia(62;0.0169)|all_hematologic(171;0.214)				AAGATATGGTGGGAATGACAA	0.418			NA											26	50					3.65163e-15	4.77672e-15	0.00632	1	0
ZNF189	7743	broad.mit.edu	37	9	104171922	104171922	+	Missense_Mutation	SNP	G	G	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr9:104171922G>T	uc004bbh.1	+	3	2148	c.1872G>T	c.(1870-1872)TGG>TGT	p.W624C	ZNF189_uc004bbg.1_Missense_Mutation_p.W582C|ZNF189_uc004bbi.1_Missense_Mutation_p.W610C|ZNF189_uc011lvk.1_Missense_Mutation_p.W609C	NM_003452	NP_003443	O75820	ZN189_HUMAN	zinc finger protein 189 isoform 1	624					negative regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)|skin(2)|kidney(1)|central_nervous_system(1)	6		Acute lymphoblastic leukemia(62;0.0559)				ACACAGCATGGATGCAATAAA	0.393			NA											7	23					2.0095e-06	2.28488e-06	0.001984	1	0
GRIN3A	116443	broad.mit.edu	37	9	104335781	104335781	+	Missense_Mutation	SNP	G	G	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr9:104335781G>A	uc004bbp.1	-	9	3624	c.3023C>T	c.(3022-3024)CCC>CTC	p.P1008L	GRIN3A_uc004bbo.1_Missense_Mutation_p.P83L	NM_133445	NP_597702	Q8TCU5	NMD3A_HUMAN	glutamate receptor, ionotropic,	1008	Cytoplasmic (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|neuron projection|neuronal cell body|outer membrane-bounded periplasmic space|postsynaptic density|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|glycine binding|identical protein binding|N-methyl-D-aspartate selective glutamate receptor activity|protein phosphatase 2A binding			ovary(4)|pancreas(1)|central_nervous_system(1)|skin(1)	7		Acute lymphoblastic leukemia(62;0.0568)			Acamprosate(DB00659)|Chloroprocaine(DB01161)|Dextromethorphan(DB00514)|Ethanol(DB00898)|Ethopropazine(DB00392)|Felbamate(DB00949)|Ketamine(DB01221)|L-Glutamic Acid(DB00142)|Memantine(DB01043)|Meperidine(DB00454)|Methadone(DB00333)|Orphenadrine(DB01173)|Procaine(DB00721)|Riluzole(DB00740)	AAGCTGACGGGGTCCCACATT	0.448			NA											17	47					0	0	0.004007	0	0
OR13C3	138803	broad.mit.edu	37	9	107298654	107298654	+	Missense_Mutation	SNP	C	C	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr9:107298654C>A	uc004bcb.1	-	1	441	c.441G>T	c.(439-441)ATG>ATT	p.M147I		NM_001001961	NP_001001961	Q8NGS6	O13C3_HUMAN	olfactory receptor, family 13, subfamily C,	147	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(1)	1						CAAATGCCATCATGCCAAGAA	0.463	GBM(86;1248 1274 14222 15028 46219)		NA											33	53					9.04072e-19	1.21323e-18	0.003271	1	0
DFNB31	25861	broad.mit.edu	37	9	117228579	117228579	+	Missense_Mutation	SNP	G	G	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr9:117228579G>A	uc004biz.3	-	3	1580	c.931C>T	c.(931-933)CCA>TCA	p.P311S	DFNB31_uc004biy.3_5'UTR|DFNB31_uc004bja.3_Missense_Mutation_p.P311S	NM_015404	NP_056219	Q9P202	WHRN_HUMAN	CASK-interacting protein CIP98 isoform 1	311	PDZ 2.				inner ear receptor stereocilium organization|retina homeostasis|sensory perception of light stimulus|sensory perception of sound	cytoplasm|growth cone|stereocilium				ovary(4)|central_nervous_system(1)|pancreas(1)	6						TCAGAGCCTGGGTCCACGCCA	0.602			NA											37	56					0	0	0.004878	0	0
OR1N2	138882	broad.mit.edu	37	9	125315507	125315507	+	Missense_Mutation	SNP	G	G	C			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr9:125315507G>C	uc011lyx.1	+	1	59	c.59G>C	c.(58-60)AGA>ACA	p.R20T		NM_001004457	NP_001004457	Q8NGR9	OR1N2_HUMAN	olfactory receptor, family 1, subfamily N,	20	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(2)	4						AAACCAGGCAGAGTGAACCAA	0.413			NA											13	47					0	0	0.001855	0	0
OR1L4	254973	broad.mit.edu	37	9	125486593	125486593	+	Missense_Mutation	SNP	G	G	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr9:125486593G>A	uc004bmu.1	+	1	325	c.325G>A	c.(325-327)GGG>AGG	p.G109R		NM_001005235	NP_001005235	Q8NGR5	OR1L4_HUMAN	olfactory receptor, family 1, subfamily L,	109	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						CATGGCATTTGGGAACACTGA	0.473			NA											41	54					0	0	0.006999	0	0
GOLGA1	2800	broad.mit.edu	37	9	127651448	127651448	+	Nonsense_Mutation	SNP	C	C	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr9:127651448C>A	uc004bpc.2	-	18	2077	c.1735G>T	c.(1735-1737)GAA>TAA	p.E579*	GOLGA1_uc010mws.2_RNA	NM_002077	NP_002068	Q92805	GOGA1_HUMAN	golgin 97	579	Potential.					Golgi cisterna membrane				ovary(1)	1						GAGAGTGCTTCGGCCTGCAAT	0.657			NA											26	32					8.24728e-16	1.0847e-15	0.004656	1	0
COL5A1	1289	broad.mit.edu	37	9	137688241	137688241	+	Missense_Mutation	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr9:137688241C>T	uc004cfe.2	+	35	3203	c.2821C>T	c.(2821-2823)CCA>TCA	p.P941S		NM_000093	NP_000084	P20908	CO5A1_HUMAN	alpha 1 type V collagen preproprotein	941	Triple-helical region.				axon guidance|cell adhesion|collagen biosynthetic process|collagen fibril organization|eye morphogenesis|fibril organization|integrin biosynthetic process|skin development|wound healing, spreading of epidermal cells	collagen type V	heparin binding|integrin binding|platelet-derived growth factor binding|proteoglycan binding			skin(4)|ovary(3)|pancreas(2)|central_nervous_system(1)|kidney(1)	11		Myeloproliferative disorder(178;0.0341)		all cancers(34;2.28e-08)|OV - Ovarian serous cystadenocarcinoma(145;6.03e-08)|Epithelial(140;6.4e-08)|GBM - Glioblastoma multiforme(294;0.131)		AGGTGACGGCCCAGCTGGCCC	0.577			NA											33	54					0	0	0.012213	0	0
ARRDC1	92714	broad.mit.edu	37	9	140508500	140508500	+	Missense_Mutation	SNP	C	C	G			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr9:140508500C>G	uc004cns.2	+	5	526	c.452C>G	c.(451-453)TCT>TGT	p.S151C	ARRDC1_uc004cnt.2_Missense_Mutation_p.S26C|ARRDC1_uc004cnu.2_RNA|ARRDC1_uc004cnv.2_Missense_Mutation_p.S131C|ARRDC1_uc004cnw.2_Missense_Mutation_p.S26C|ARRDC1_uc004cnp.1_Missense_Mutation_p.S151C|ARRDC1_uc004cnq.1_Missense_Mutation_p.S133C|ARRDC1_uc011mfb.1_Missense_Mutation_p.S26C|ARRDC1_uc004cnx.1_Missense_Mutation_p.S26C|ARRDC1_uc004cny.2_RNA	NM_152285	NP_689498	Q8N5I2	ARRD1_HUMAN	arrestin domain containing 1	151											0	all_cancers(76;0.106)			OV - Ovarian serous cystadenocarcinoma(145;0.000273)|Epithelial(140;0.000464)		AACGTGGCCTCTGCCACCAAG	0.652			NA											25	80					0	0	0.003954	0	0
SLC25A6	293	broad.mit.edu	37	X	1508207	1508207	+	Missense_Mutation	SNP	C	C	G			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chrX:1508207C>G	uc004cpt.2	-	2	621	c.525G>C	c.(523-525)CAG>CAC	p.Q175H	SLC25A6_uc004cpu.2_RNA	NM_001636	NP_001627	P12236	ADT3_HUMAN	adenine nucleotide translocator 3	175	Solcar 2.				active induction of host immune response by virus|apoptosis|energy reserve metabolic process|regulation of insulin secretion|viral infectious cycle	integral to membrane|mitochondrial inner membrane presequence translocase complex	ATP:ADP antiporter activity|protein binding				0		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)			Clodronate(DB00720)	CACTGAAGCCCTGGTACAGGC	0.567			NA											34	121					0	0	0.012213	0	0
SLC25A6	293	broad.mit.edu	37	X	1508329	1508329	+	Missense_Mutation	SNP	C	C	G	rs140307739		TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chrX:1508329C>G	uc004cpt.2	-	2	499	c.403G>C	c.(403-405)GAT>CAT	p.D135H	SLC25A6_uc004cpu.2_RNA	NM_001636	NP_001627	P12236	ADT3_HUMAN	adenine nucleotide translocator 3	135	Solcar 2.|Helical; Name=3; (By similarity).				active induction of host immune response by virus|apoptosis|energy reserve metabolic process|regulation of insulin secretion|viral infectious cycle	integral to membrane|mitochondrial inner membrane presequence translocase complex	ATP:ADP antiporter activity|protein binding				0		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)			Clodronate(DB00720)	CTGGCGAAATCCAGCGGGTAC	0.657			NA											29	132					0	0	0.010818	0	0
DHRSX	207063	broad.mit.edu	37	X	2209550	2209550	+	Silent	SNP	G	G	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chrX:2209550G>A	uc004cqf.3	-	4	430	c.381C>T	c.(379-381)ATC>ATT	p.I127I		NM_145177	NP_660160	Q8N5I4	DHRSX_HUMAN	dehydrogenase/reductase (SDR family) X-linked	127							binding|oxidoreductase activity				0		all_cancers(21;9e-05)|all_epithelial(21;6.22e-06)|all_lung(23;0.000597)|Lung NSC(23;0.00901)|Lung SC(21;0.186)				CACCATTGTTGATCAGGACAT	0.443			NA											14	47					0	0	0.00245	0	0
ASB9	140462	broad.mit.edu	37	X	15268584	15268584	+	Missense_Mutation	SNP	T	T	C			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chrX:15268584T>C	uc004cwl.2	-	5	783	c.536A>G	c.(535-537)CAG>CGG	p.Q179R	ASB9_uc004cwk.2_Missense_Mutation_p.Q179R|ASB9_uc004cwm.2_Missense_Mutation_p.Q169R|ASB9_uc010ner.2_Missense_Mutation_p.Q179R|ASB9_uc004cwn.2_Missense_Mutation_p.Q150R	NM_001031739	NP_001026909	Q96DX5	ASB9_HUMAN	ankyrin repeat and SOCS box-containing 9 isoform	179	ANK 5.				intracellular signal transduction						0	Hepatocellular(33;0.183)					ACAGGCTCTCTGTTGGTTTTC	0.403			NA											17	48					0	0	0.007413	0	0
MAGEB6	158809	broad.mit.edu	37	X	26212971	26212971	+	Missense_Mutation	SNP	G	G	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chrX:26212971G>T	uc004dbr.2	+	2	1157	c.1008G>T	c.(1006-1008)TTG>TTT	p.L336F	MAGEB6_uc010ngc.1_Missense_Mutation_p.L116F	NM_173523	NP_775794	Q8N7X4	MAGB6_HUMAN	melanoma antigen family B, 6	336	MAGE.									ovary(3)	3						CTGAAGATTTGGTGCAAGATA	0.498			NA											27	90					6.00712e-18	8.01686e-18	0.012213	1	0
FTHL17	53940	broad.mit.edu	37	X	31089993	31089993	+	Silent	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chrX:31089993C>T	uc004dcl.1	-	1	181	c.78G>A	c.(76-78)ACG>ACA	p.T26T		NM_031894	NP_114100	Q9BXU8	FHL17_HUMAN	ferritin, heavy polypeptide-like 17	26	Ferritin-like diiron.				cellular iron ion homeostasis|iron ion transport		ferric iron binding|oxidoreductase activity				0						AGAGCTCCAGCGTGATGTGGC	0.627			NA											19	51					0	0	0.007413	0	0
DUSP21	63904	broad.mit.edu	37	X	44703735	44703735	+	Silent	SNP	G	G	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chrX:44703735G>A	uc004dgd.2	+	1	487	c.357G>A	c.(355-357)GCG>GCA	p.A119A		NM_022076	NP_071359	Q9H596	DUS21_HUMAN	dual specificity phosphatase 21	119	Tyrosine-protein phosphatase.|Sufficient for mitochondrial localization (By similarity).					cytoplasm|nucleus	MAP kinase tyrosine/serine/threonine phosphatase activity|protein tyrosine phosphatase activity			large_intestine(1)|lung(1)	2						TGTGCCTTGCGTACCTCATGA	0.587			NA											16	47					0	0	0.00499	0	0
PQBP1	10084	broad.mit.edu	37	X	48758546	48758546	+	Silent	SNP	A	A	C			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chrX:48758546A>C	uc004dle.2	+	3	336	c.147A>C	c.(145-147)CCA>CCC	p.P49P	PQBP1_uc004dlf.2_Silent_p.P49P|PQBP1_uc004dlg.2_Silent_p.P49P|PQBP1_uc004dld.2_RNA|PQBP1_uc004dlh.2_Silent_p.P49P|PQBP1_uc004dli.2_Silent_p.P49P|PQBP1_uc004dlj.1_Silent_p.P49P|PQBP1_uc004dln.2_Silent_p.P49P|PQBP1_uc010nih.2_RNA|PQBP1_uc010nii.2_5'UTR|PQBP1_uc004dlk.2_Silent_p.P49P|PQBP1_uc004dll.2_Missense_Mutation_p.H17P|PQBP1_uc004dlm.2_5'UTR|PQBP1_uc010nij.2_Silent_p.P49P	NM_001032382	NP_001027554	O60828	PQBP1_HUMAN	polyglutamine binding protein 1	49	WW.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|transcription coactivator activity			large_intestine(1)	1						AGGGCCTACCACCAAGCTGGT	0.557			NA											4	7					0	0	0.009096	0	0
PHKA1	5255	broad.mit.edu	37	X	71800926	71800926	+	Missense_Mutation	SNP	T	T	C			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chrX:71800926T>C	uc004eax.3	-	32	3899	c.3598A>G	c.(3598-3600)ATG>GTG	p.M1200V	PHKA1_uc004eay.3_Missense_Mutation_p.M1187V|PHKA1_uc011mqi.1_Missense_Mutation_p.M1128V|PHKA1_uc010nll.2_Missense_Mutation_p.M232V	NM_002637	NP_002628	P46020	KPB1_HUMAN	phosphorylase kinase, alpha 1 (muscle) isoform	1200					glucose metabolic process|glycogen catabolic process	cytosol|plasma membrane	calmodulin binding|glucan 1,4-alpha-glucosidase activity|phosphorylase kinase activity			ovary(3)|skin(1)	4	Renal(35;0.156)					AGGTAGGTCATGGTGCCAAAC	0.562			NA											5	15					0	0	0.001168	0	0
MAGEE2	139599	broad.mit.edu	37	X	75003878	75003878	+	Missense_Mutation	SNP	G	G	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chrX:75003878G>T	uc004ecj.1	-	1	1194	c.1009C>A	c.(1009-1011)CTA>ATA	p.L337I		NM_138703	NP_619648	Q8TD90	MAGE2_HUMAN	melanoma antigen family E, 2	337	MAGE 2.									ovary(1)|skin(1)	2						TGAGCCAATAGCTCATCCTGA	0.418			NA											11	38					0.00829132	0.00852017	0.008291	1	0
KLHL4	56062	broad.mit.edu	37	X	86868907	86868907	+	Missense_Mutation	SNP	G	G	C			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chrX:86868907G>C	uc004efb.2	+	2	632	c.450G>C	c.(448-450)ATG>ATC	p.M150I	KLHL4_uc004efa.2_Missense_Mutation_p.M150I	NM_019117	NP_061990	Q9C0H6	KLHL4_HUMAN	kelch-like 4 isoform 1	150						cytoplasm|microtubule cytoskeleton|nucleolus	actin binding			ovary(2)|lung(1)|breast(1)|central_nervous_system(1)	5						CTGAAGACATGAATGCCACCA	0.333			NA											5	9					0	0	0.001168	0	0
NAP1L3	4675	broad.mit.edu	37	X	92927019	92927019	+	Missense_Mutation	SNP	T	T	C			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chrX:92927019T>C	uc004efq.2	-	1	1590	c.1285A>G	c.(1285-1287)ATC>GTC	p.I429V	FAM133A_uc004efr.1_5'Flank	NM_004538	NP_004529	Q99457	NP1L3_HUMAN	nucleosome assembly protein 1-like 3	429					nucleosome assembly	chromatin assembly complex				ovary(1)|skin(1)	2						CTTGGCTGGATTTCAATTTCT	0.433			NA											4	2					0	0	0.009096	0	0
DIAPH2	1730	broad.mit.edu	37	X	96220166	96220166	+	Silent	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chrX:96220166C>T	uc004efu.3	+	17	2406	c.2010C>T	c.(2008-2010)CTC>CTT	p.L670L	DIAPH2_uc004eft.3_Silent_p.L670L	NM_006729	NP_006720	O60879	DIAP2_HUMAN	diaphanous 2 isoform 156	670	FH2.				cell differentiation|cytokinesis|multicellular organismal development|oogenesis	cytosol|early endosome|Golgi apparatus|mitochondrion|nucleolus	receptor binding|Rho GTPase binding			ovary(3)|lung(1)	4						ATCCAGATCTCTTTGCCAAAT	0.303			NA											3	6					0	0	0.009096	0	0
MCART6	401612	broad.mit.edu	37	X	103349497	103349497	+	Missense_Mutation	SNP	T	T	G			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chrX:103349497T>G	uc004elu.2	-	2	625	c.444A>C	c.(442-444)CAA>CAC	p.Q148H		NM_001012755	NP_001012773	Q5H9E4	MCAR6_HUMAN	mitochondrial carrier triple repeat 6	148	Solcar 2.				transport	integral to membrane|mitochondrial inner membrane					0						GGAAGCGAGCTTGCTTGCGAC	0.587			NA											40	116					0	0	0.00623	0	0
TBC1D8B	54885	broad.mit.edu	37	X	106084040	106084040	+	Missense_Mutation	SNP	G	G	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chrX:106084040G>A	uc004emo.2	+	10	1810	c.1645G>A	c.(1645-1647)GAT>AAT	p.D549N	MORC4_uc004emp.3_Intron|TBC1D8B_uc004emn.2_Missense_Mutation_p.D549N	NM_017752	NP_060222	Q0IIM8	TBC8B_HUMAN	TBC1 domain family, member 8B (with GRAM domain)	549	Rab-GAP TBC.					intracellular	calcium ion binding|Rab GTPase activator activity			ovary(2)|central_nervous_system(1)|skin(1)	4						CTTTCAGAGTGATACTGGCAT	0.473			NA											22	35					0	0	0.014323	0	0
COL4A6	1288	broad.mit.edu	37	X	107554022	107554023	+	Missense_Mutation	DNP	CC	CC	AA			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chrX:107554022_107554023CC>AA	uc004enw.3	-	3	205_206	c.102_103GG>TT	c.(100-105)CAGGAC>CATTAC	p.34_35QD>HY	COL4A6_uc004env.3_Missense_Mutation_p.33_34QD>HY|COL4A6_uc011msn.1_Missense_Mutation_p.33_34QD>HY|COL4A6_uc010npk.2_Missense_Mutation_p.33_34QD>HY|COL4A6_uc004enx.2_RNA|COL4A6_uc004eny.2_RNA	NM_001847	NP_001838	Q14031	CO4A6_HUMAN	type IV alpha 6 collagen isoform A precursor	34_35	7S domain.				cell adhesion|extracellular matrix organization	collagen type IV	extracellular matrix structural constituent|protein binding			ovary(6)|urinary_tract(1)|large_intestine(1)	8						CCACTGCAGTCCTGGCCCCCAC	0.436	Melanoma(87;1895 1945 2589 7165)		NA							Alport_syndrome_with_Diffuse_Leiomyomatosis				10	45					0	0	0.004672	0	0
HTR2C	3358	broad.mit.edu	37	X	113965884	113965884	+	Missense_Mutation	SNP	C	C	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chrX:113965884C>A	uc004epu.1	+	4	945	c.217C>A	c.(217-219)CTT>ATT	p.L73I	HTR2C_uc010nqc.1_Missense_Mutation_p.L73I|HTR2C_uc004epv.1_Missense_Mutation_p.L73I	NM_000868	NP_000859	P28335	5HT2C_HUMAN	5-hydroxytryptamine (serotonin) receptor 2C	73	Helical; Name=1; (By similarity).				cGMP biosynthetic process|ERK1 and ERK2 cascade|feeding behavior|phosphatidylinositol biosynthetic process|release of sequestered calcium ion into cytosol|response to drug|synaptic transmission	cytoplasm|integral to membrane|nucleus|plasma membrane	1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding|drug binding|phosphatidylinositol phospholipase C activity|protein binding|serotonin binding|serotonin receptor activity			ovary(3)	3					Chlorprothixene(DB01239)|Clozapine(DB00363)|Dexfenfluramine(DB01191)|Fenfluramine(DB00574)|Methysergide(DB00247)|Mianserin(DB06148)|Minaprine(DB00805)|Mirtazapine(DB00370)|Olanzapine(DB00334)|Promazine(DB00420)|Propiomazine(DB00777)|Quetiapine(DB01224)|Sertindole(DB06144)|Thiethylperazine(DB00372)|Tramadol(DB00193)|Ziprasidone(DB00246)	TGGCAACATCCTTGTGATCAT	0.443			NA											15	36					2.31682e-05	2.54658e-05	0.003163	1	0
ODZ1	10178	broad.mit.edu	37	X	123556156	123556156	+	Silent	SNP	G	G	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chrX:123556156G>A	uc004euj.2	-	23	4480	c.4416C>T	c.(4414-4416)GAC>GAT	p.D1472D	ODZ1_uc011muj.1_Silent_p.D1478D|ODZ1_uc010nqy.2_Silent_p.D1479D	NM_014253	NP_055068	Q9UKZ4	TEN1_HUMAN	odz, odd Oz/ten-m homolog 1 isoform 3	1472	Extracellular (Potential).				immune response|negative regulation of cell proliferation|nervous system development|signal transduction	extracellular region	heparin binding			ovary(11)|breast(4)|large_intestine(2)|skin(2)|pancreas(2)|upper_aerodigestive_tract(1)|lung(1)	23						CAATTTTGCAGTCACAGTCAG	0.448			NA											18	42					0	0	0.00499	0	0
DCAF12L2	340578	broad.mit.edu	37	X	125298590	125298590	+	Nonsense_Mutation	SNP	C	C	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chrX:125298590C>A	uc004euk.1	-	1	1345	c.1318G>T	c.(1318-1320)GAG>TAG	p.E440*		NM_001013628	NP_001013650	Q5VW00	DC122_HUMAN	DDB1 and CUL4 associated factor 12-like 2	440										lung(2)|skin(2)|large_intestine(1)|pancreas(1)|ovary(1)	7						AGCTTCATCTCCGGCCAGTTG	0.577			NA											34	86					6.53348e-20	8.80836e-20	0.003755	1	0
FHL1	2273	broad.mit.edu	37	X	135288688	135288688	+	Missense_Mutation	SNP	G	G	C			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chrX:135288688G>C	uc004ezo.2	+	2	197	c.97G>C	c.(97-99)GAC>CAC	p.D33H	FHL1_uc010nrz.2_Missense_Mutation_p.D33H|FHL1_uc004ezm.2_RNA|FHL1_uc004ezl.2_Missense_Mutation_p.D33H|FHL1_uc004ezq.2_Missense_Mutation_p.D33H|FHL1_uc011mvy.1_Missense_Mutation_p.D33H|FHL1_uc011mvz.1_Missense_Mutation_p.D33H|FHL1_uc004ezn.2_Missense_Mutation_p.D33H|FHL1_uc011mwa.1_Missense_Mutation_p.D62H|FHL1_uc011mwb.1_RNA|FHL1_uc004ezp.2_Missense_Mutation_p.D49H|FHL1_uc004ezr.2_5'Flank	NM_001159702	NP_001153174	Q13642	FHL1_HUMAN	four and a half LIM domains 1 isoform 1	33					cell differentiation|cell growth|muscle organ development|organ morphogenesis	cytosol|nucleus|plasma membrane	protein binding|zinc ion binding				0	Acute lymphoblastic leukemia(192;0.000127)					GAAATGCTTTGACAAGTTCTG	0.557			NA											62	135					0	0	0.01441	0	0
GPR112	139378	broad.mit.edu	37	X	135431523	135431523	+	Silent	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chrX:135431523C>T	uc004ezu.1	+	6	5949	c.5658C>T	c.(5656-5658)CCC>CCT	p.P1886P	GPR112_uc010nsb.1_Silent_p.P1681P|GPR112_uc010nsc.1_Silent_p.P1653P	NM_153834	NP_722576	Q8IZF6	GP112_HUMAN	G-protein coupled receptor 112	1886	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(5)|large_intestine(2)|skin(2)|lung(1)|breast(1)|pancreas(1)	12	Acute lymphoblastic leukemia(192;0.000127)					GGAACATACCCACAGCTGAAG	0.443			NA											22	48					0	0	0.012319	0	0
ZIC3	7547	broad.mit.edu	37	X	136649681	136649681	+	Silent	SNP	G	G	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chrX:136649681G>A	uc004fak.2	+	1	1336	c.831G>A	c.(829-831)GAG>GAA	p.E277E		NM_003413	NP_003404	O60481	ZIC3_HUMAN	zinc finger protein of the cerebellum 3	277	C2H2-type 1; atypical.				cell differentiation|positive regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)|breast(1)	3	Acute lymphoblastic leukemia(192;0.000127)					CCATGCATGAGCTGGTGACAC	0.617			NA											23	69					0	0	0.014323	0	0
MAGEC1	9947	broad.mit.edu	37	X	140995104	140995104	+	Silent	SNP	C	C	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chrX:140995104C>A	uc004fbt.2	+	4	2200	c.1914C>A	c.(1912-1914)TCC>TCA	p.S638S	MAGEC1_uc010nsl.1_Intron	NM_005462	NP_005453	O60732	MAGC1_HUMAN	melanoma antigen family C, 1	638							protein binding			ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	4	Acute lymphoblastic leukemia(192;6.56e-05)					CCACTCCATCCAGTCTTCCCC	0.567			NA								HNSCC(15;0.026)			76	182					3.4779e-39	4.87914e-39	0.01441	1	0
SLITRK4	139065	broad.mit.edu	37	X	142716437	142716438	+	Missense_Mutation	DNP	CC	CC	GA			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chrX:142716437_142716438CC>GA	uc004fbx.2	-	2	2863_2864	c.2487_2488GG>TC	c.(2485-2490)GAGGAG>GATCAG	p.829_830EE>DQ	SLITRK4_uc004fby.2_Missense_Mutation_p.829_830EE>DQ	NM_173078	NP_775101	Q8IW52	SLIK4_HUMAN	slit and trk like 4 protein precursor	829_830	Cytoplasmic (Potential).					integral to membrane				upper_aerodigestive_tract(1)|large_intestine(1)	2	Acute lymphoblastic leukemia(192;6.56e-05)					GCTGTTTGCTCCTCAAGGACCT	0.401			NA											7	38					0	0	0.004672	0	0
MAGEA11	4110	broad.mit.edu	37	X	148797297	148797297	+	Missense_Mutation	SNP	A	A	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chrX:148797297A>T	uc004fdq.2	+	4	328	c.226A>T	c.(226-228)AGT>TGT	p.S76C	HSFX2_uc004fdl.2_Intron|HSFX1_uc004fdm.2_Intron|MAGEA11_uc004fdr.2_Missense_Mutation_p.S47C	NM_005366	NP_005357	P43364	MAGAB_HUMAN	melanoma antigen family A, 11 isoform a	76						cytoplasm|nucleus	protein binding			ovary(2)	2	Acute lymphoblastic leukemia(192;6.56e-05)|Colorectal(9;0.0662)					GGAGGACAGGAGTCCCAGGAG	0.502			NA											36	65					0	0	0.003755	0	0
CD99L2	83692	broad.mit.edu	37	X	149999767	149999767	+	Splice_Site	SNP	C	C	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chrX:149999767C>A	uc004fel.2	-	2	186	c.68_splice	c.e2-1	p.G23_splice	CD99L2_uc004fem.2_Splice_Site_p.G23_splice|CD99L2_uc004fen.2_Splice_Site_p.G23_splice|CD99L2_uc004feo.2_Splice_Site|CD99L2_uc011myb.1_Splice_Site_p.G23_splice	NM_031462	NP_113650	Q8TCZ2	C99L2_HUMAN	CD99 antigen-like 2 isoform E3'-E4'-E3-E4						cell adhesion	cell junction|integral to membrane				large_intestine(2)|ovary(1)	3	Acute lymphoblastic leukemia(192;6.56e-05)					TCCCCAGATCCtaaaaattaa	0.264			NA											14	29					4.36969e-10	5.34523e-10	0.001855	1	0
CNGA2	1260	broad.mit.edu	37	X	150912332	150912332	+	Missense_Mutation	SNP	C	C	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chrX:150912332C>A	uc004fey.1	+	7	1581	c.1357C>A	c.(1357-1359)CGC>AGC	p.R453S		NM_005140	NP_005131	Q16280	CNGA2_HUMAN	cyclic nucleotide gated channel alpha 2	453	Extracellular (Potential).				response to stimulus|sensory perception of smell	intracellular cyclic nucleotide activated cation channel complex	cAMP binding|intracellular cAMP activated cation channel activity			breast(3)	3	Acute lymphoblastic leukemia(192;6.56e-05)					CAAGAAAGTGCGCATCTTCCA	0.418			NA											13	41					9.31168e-06	1.04004e-05	0.001855	1	0
F8	2157	broad.mit.edu	37	X	154133184	154133184	+	Missense_Mutation	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chrX:154133184C>T	uc004fmt.2	-	16	5659	c.5488G>A	c.(5488-5490)GAA>AAA	p.E1830K	F8_uc010nvi.1_5'UTR	NM_000132	NP_000123	P00451	FA8_HUMAN	coagulation factor VIII isoform a precursor	1830	F5/8 type A 3.|Plastocyanin-like 5.				acute-phase response|blood coagulation, intrinsic pathway|cell adhesion|platelet activation|platelet degranulation	extracellular space|plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity|protein binding			ovary(5)|large_intestine(2)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	11	all_cancers(53;7.19e-17)|all_epithelial(53;9.83e-11)|all_lung(58;6.63e-07)|Lung NSC(58;2.08e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)				Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Drotrecogin alfa(DB00055)	GTTTTGGTTTCATTAGGCTTG	0.418			NA											9	22					0	0	0.004482	0	0
VAMP7	6845	broad.mit.edu	37	X	155171561	155171561	+	Silent	SNP	C	C	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chrX:155171561C>T	uc004fnr.2	+	8	783	c.609C>T	c.(607-609)ATC>ATT	p.I203I	VAMP7_uc004fnt.2_Silent_p.I162I|VAMP7_uc011naa.1_Silent_p.I164I|VAMP7_uc011nab.1_Silent_p.I102I|VAMP7_uc004fns.2_Missense_Mutation_p.H181Y|VAMP7_uc011nac.1_Silent_p.I136I	NM_005638	NP_005629	P51809	VAMP7_HUMAN	vesicle-associated membrane protein 7 isoform 1	203	Helical; Anchor for type IV membrane protein; (Potential).				calcium ion-dependent exocytosis|endosome to lysosome transport|eosinophil degranulation|ER to Golgi vesicle-mediated transport|neutrophil degranulation|phagocytosis, engulfment|post-Golgi vesicle-mediated transport|protein transport|vesicle fusion	endoplasmic reticulum membrane|Golgi apparatus|integral to membrane|late endosome membrane|lysosomal membrane|phagocytic vesicle membrane|plasma membrane|SNARE complex|transport vesicle membrane	protein binding				0	all_cancers(53;1.86e-17)|all_epithelial(53;2.71e-11)|all_lung(58;1.84e-07)|Lung NSC(58;5.62e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)					TCATCTATATCATTGTTTCAC	0.348			NA											7	26					0	0	0.001984	0	0
ARID1A	8289	broad.mit.edu	37	1	27097629	27097629	+	Frame_Shift_Del	DEL	G	G	-			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr1:27097629delG	uc001bmv.1	+	12	3591	c.3218delG	c.(3217-3219)TGGfs	p.W1073fs	ARID1A_uc001bmt.1_Frame_Shift_Del_p.W1073fs|ARID1A_uc001bmu.1_Frame_Shift_Del_p.W1073fs|ARID1A_uc001bmw.1_Frame_Shift_Del_p.W690fs|ARID1A_uc001bmx.1_Translation_Start_Site|ARID1A_uc009vsm.1_5'Flank	NM_006015	NP_006006	O14497	ARI1A_HUMAN	AT rich interactive domain 1A isoform a	1073	ARID.			W->A: Partial loss of DNA-binding activity. Complete loss of activity; when associated with A-1096.	androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding			ovary(124)|pancreas(5)|central_nervous_system(3)|endometrium(3)|kidney(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	142		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		AACAAAAAATGGCGGGAACTT	0.488			NA	Mis|N|F|S|D		clear cell ovarian carcinoma|RCC								13	32	---	---	---	---	NA	NA	NA	NA	NA
COL9A2	1298	broad.mit.edu	37	1	40777384	40777384	+	Frame_Shift_Del	DEL	C	C	-			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr1:40777384delC	uc001cfh.1	-	9	491	c.421delG	c.(421-423)GACfs	p.D141fs	COL9A2_uc001cfi.1_5'UTR	NM_001852	NP_001843	Q14055	CO9A2_HUMAN	alpha 2 type IX collagen precursor	141	Triple-helical region 4 (COL4).				axon guidance|skeletal system development	collagen type IX		p.D141N(1)		ovary(2)	2	Lung NSC(20;4.38e-06)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;2.08e-17)			GGTCCAGGGTCCCCCTGGAAG	0.622			NA											51	65	---	---	---	---	NA	NA	NA	NA	NA
WLS	79971	broad.mit.edu	37	1	68624901	68624901	+	Frame_Shift_Del	DEL	A	A	-			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr1:68624901delA	uc001def.1	-	3	680	c.409delT	c.(409-411)TCCfs	p.S137fs	uc001deb.1_Intron|uc001dec.1_Intron|WLS_uc001dee.2_Frame_Shift_Del_p.S135fs|WLS_uc001deg.1_Frame_Shift_Del_p.S46fs|WLS_uc009wbf.1_Frame_Shift_Del_p.S92fs	NM_024911	NP_079187	Q5T9L3	WLS_HUMAN	G protein-coupled receptor 177 isoform 1	137	Lumenal (Potential).|Interacts with Wnt proteins (By similarity).				multicellular organismal development|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|Wnt receptor signaling pathway	cytoplasmic vesicle membrane|Golgi membrane|integral to membrane	signal transducer activity				0						TAAGCCAGGGAAACGTCCATG	0.438			NA											14	62	---	---	---	---	NA	NA	NA	NA	NA
CLCA2	9635	broad.mit.edu	37	1	86919069	86919070	+	Frame_Shift_Del	DEL	GC	GC	-			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	GC	GC	-	-	GC	GC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr1:86919069_86919070delGC	uc001dlr.3	+	13	2335_2336	c.2173_2174delGC	c.(2173-2175)GCTfs	p.A725fs		NM_006536	NP_006527	Q9UQC9	CLCA2_HUMAN	chloride channel accessory 2 precursor	725	Extracellular (Potential).				cell adhesion	basal plasma membrane|cell junction|extracellular region|integral to plasma membrane	chloride channel activity			ovary(1)|breast(1)|skin(1)	3		Lung NSC(277;0.238)		all cancers(265;0.0233)|Epithelial(280;0.0452)		TCAGATGAATGCTCCAAGGAAA	0.436	Melanoma(157;1000 1898 5363 5664 48018)|Ovarian(88;135 1366 2838 28875 34642)		NA											9	38	---	---	---	---	NA	NA	NA	NA	NA
ZDHHC16	84287	broad.mit.edu	37	10	99212032	99212036	+	Frame_Shift_Del	DEL	CCCAC	CCCAC	-			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	CCCAC	CCCAC	-	-	CCCAC	CCCAC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr10:99212032_99212036delCCCAC	uc001knj.2	+	4	778_782	c.429_433delCCCAC	c.(427-435)TACCCACCCfs	p.Y143fs	ZDHHC16_uc001knp.2_Frame_Shift_Del_p.Y143fs|ZDHHC16_uc001knk.2_Frame_Shift_Del_p.Y143fs|ZDHHC16_uc001knl.2_Frame_Shift_Del_p.Y143fs|ZDHHC16_uc001knm.2_Intron|ZDHHC16_uc001knn.2_Frame_Shift_Del_p.Y143fs|ZDHHC16_uc010qow.1_Frame_Shift_Del_p.Y143fs|ZDHHC16_uc009xvq.2_RNA|ZDHHC16_uc001kno.2_Frame_Shift_Del_p.Y143fs|ZDHHC16_uc009xvr.2_Frame_Shift_Del_p.Y143fs	NM_198046	NP_932163	Q969W1	ZDH16_HUMAN	Abl-philin 2 isoform 1	143_145	Cytoplasmic (Potential).				apoptosis	endoplasmic reticulum membrane|integral to membrane	acyltransferase activity|zinc ion binding			ovary(1)	1		Colorectal(252;0.0846)		Epithelial(162;5.81e-10)|all cancers(201;4.19e-08)		CGCCTGGGTACCCACCCCAGGTGGG	0.546			NA											11	106	---	---	---	---	NA	NA	NA	NA	NA
PAX2	5076	broad.mit.edu	37	10	102509593	102509593	+	Frame_Shift_Del	DEL	C	C	-			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr10:102509593delC	uc001krk.3	+	2	684	c.134delC	c.(133-135)GCCfs	p.A45fs	PAX2_uc001krl.3_Frame_Shift_Del_p.A45fs|PAX2_uc001krm.3_Frame_Shift_Del_p.A45fs|PAX2_uc001kro.3_Frame_Shift_Del_p.A45fs|PAX2_uc001krn.3_Frame_Shift_Del_p.A45fs|PAX2_uc010qps.1_Frame_Shift_Del_p.A44fs|PAX2_uc001krp.1_Frame_Shift_Del_p.A49fs	NM_003990	NP_003981	Q02962	PAX2_HUMAN	paired box protein 2 isoform e	45	Paired.				anti-apoptosis|axonogenesis|brain morphogenesis|branching involved in ureteric bud morphogenesis|cell fate determination|cellular response to glucose stimulus|cellular response to hydrogen peroxide|cellular response to retinoic acid|cochlea development|glial cell differentiation|inner ear morphogenesis|mesenchymal to epithelial transition involved in metanephros morphogenesis|mesodermal cell fate specification|mesonephros development|metanephric collecting duct development|metanephric distal convoluted tubule development|metanephric mesenchymal cell differentiation|metanephric nephron tubule formation|negative regulation of caspase activity|negative regulation of cytolysis|negative regulation of mesenchymal stem cell apoptosis involved in metanephric nephron morphogenesis|negative regulation of reactive oxygen species metabolic process|negative regulation of transcription, DNA-dependent|nephric duct formation|neural tube closure|optic chiasma development|optic cup morphogenesis involved in camera-type eye development|optic nerve structural organization|positive regulation of branching involved in ureteric bud morphogenesis|positive regulation of epithelial cell proliferation|positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis|positive regulation of metanephric DCT cell differentiation|positive regulation of metanephric glomerulus development|positive regulation of optic nerve formation|positive regulation of transcription from RNA polymerase II promoter|pronephric field specification|protein kinase B signaling cascade|reactive oxygen species metabolic process|regulation of metanephric nephron tubule epithelial cell differentiation|regulation of metanephros size|retinal pigment epithelium development|stem cell differentiation|transcription from RNA polymerase II promoter|ureter maturation|vestibulocochlear nerve formation|visual perception	centriolar satellite|nucleus|protein complex|protein-DNA complex	core promoter proximal region sequence-specific DNA binding|superoxide-generating NADPH oxidase activity				0		Colorectal(252;0.234)		Epithelial(162;1.32e-08)|all cancers(201;7.32e-07)		GTGGAGCTGGCCCACCAGGGT	0.687			NA											9	69	---	---	---	---	NA	NA	NA	NA	NA
OR51M1	390059	broad.mit.edu	37	11	5411244	5411244	+	Frame_Shift_Del	DEL	T	T	-			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr11:5411244delT	uc010qzc.1	+	1	616	c.616delT	c.(616-618)TTCfs	p.F206fs	HBG2_uc001mak.1_Intron|HBE1_uc001mam.1_Intron|OR51B5_uc001maq.1_Intron	NM_001004756	NP_001004756	B2RNI9	B2RNI9_HUMAN	olfactory receptor, family 51, subfamily M,	206						integral to membrane	olfactory receptor activity				0		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;1.98e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		AGATATCACCTTCAATAATCT	0.512			NA											18	89	---	---	---	---	NA	NA	NA	NA	NA
TTC12	54970	broad.mit.edu	37	11	113235648	113235649	+	Frame_Shift_Ins	INS	-	-	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr11:113235648_113235649insA	uc001pnu.2	+	21	2013_2014	c.1908_1909insA	c.(1906-1911)CCCAACfs	p.P636fs	TTC12_uc001pnv.2_Frame_Shift_Ins_p.P642fs|TTC12_uc001pnw.2_RNA|TTC12_uc001pnx.2_Frame_Shift_Ins_p.P486fs	NM_017868	NP_060338	Q9H892	TTC12_HUMAN	tetratricopeptide repeat domain 12	636_637							binding			pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	4		all_cancers(61;2.73e-16)|all_epithelial(67;8.64e-10)|Melanoma(852;1.46e-05)|all_hematologic(158;0.00014)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0101)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)|Prostate(24;0.183)|Renal(330;0.187)		BRCA - Breast invasive adenocarcinoma(274;5.3e-06)|Epithelial(105;8.37e-05)|all cancers(92;0.000694)		TGGAGGTGCCCAACGTTGCGTC	0.559			NA											7	92	---	---	---	---	NA	NA	NA	NA	NA
HTR3A	3359	broad.mit.edu	37	11	113860407	113860407	+	Frame_Shift_Del	DEL	A	A	-			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr11:113860407delA	uc010rxb.1	+	8	1706	c.1473delA	c.(1471-1473)CTAfs	p.L491fs	HTR3A_uc010rxa.1_Frame_Shift_Del_p.L459fs|HTR3A_uc009yyx.2_RNA|HTR3A_uc010rxc.1_Frame_Shift_Del_p.L438fs	NM_213621	NP_998786	P46098	5HT3A_HUMAN	5-hydroxytryptamine (serotonin) receptor 3A	453	Cytoplasmic (Potential).				digestion|synaptic transmission	cell junction|integral to plasma membrane|postsynaptic membrane	serotonin binding|serotonin receptor activity|serotonin-activated cation-selective channel activity				0		all_cancers(61;2.31e-17)|all_epithelial(67;2.1e-10)|all_hematologic(158;4.64e-05)|Melanoma(852;0.000312)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0101)|all_neural(223;0.0281)|Prostate(24;0.0294)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;2.71e-06)|Epithelial(105;2.58e-05)|all cancers(92;0.000238)|OV - Ovarian serous cystadenocarcinoma(223;0.191)	Alosetron(DB00969)|Chloroprocaine(DB01161)|Cisapride(DB00604)|Dolasetron(DB00757)|Granisetron(DB00889)|Mirtazapine(DB00370)|Ondansetron(DB00904)|Palonosetron(DB00377)|Procaine(DB00721)|Tubocurarine(DB01199)	ACAAGCTGCTATTCCACATTT	0.592			NA											25	118	---	---	---	---	NA	NA	NA	NA	NA
PDE3A	5139	broad.mit.edu	37	12	20522956	20522956	+	Frame_Shift_Del	DEL	G	G	-			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr12:20522956delG	uc001reh.1	+	1	760	c.738delG	c.(736-738)GTGfs	p.V246fs		NM_000921	NP_000912	Q14432	PDE3A_HUMAN	phosphodiesterase 3A	246	Helical; (Potential).				lipid metabolic process|platelet activation|signal transduction	cytosol|integral to membrane	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cGMP-inhibited cyclic-nucleotide phosphodiesterase activity|metal ion binding			ovary(3)|upper_aerodigestive_tract(1)	4	Esophageal squamous(101;0.125)	Breast(259;0.134)			Aminophylline(DB01223)|Amrinone(DB01427)|Anagrelide(DB00261)|Cilostazol(DB01166)|Enoximone(DB04880)|Milrinone(DB00235)|Theophylline(DB00277)	TGGCCGGCGTGCTGGGGATCC	0.607			NA											15	53	---	---	---	---	NA	NA	NA	NA	NA
OR6C4	341418	broad.mit.edu	37	12	55945160	55945160	+	Frame_Shift_Del	DEL	C	C	-			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr12:55945160delC	uc010spp.1	+	1	150	c.150delC	c.(148-150)GACfs	p.D50fs		NM_001005494	NP_001005494	Q8NGE1	OR6C4_HUMAN	olfactory receptor, family 6, subfamily C,	50	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						CCTTACTAGACCCCCACCTCC	0.418			NA											18	123	---	---	---	---	NA	NA	NA	NA	NA
NAV3	89795	broad.mit.edu	37	12	78400665	78400665	+	Frame_Shift_Del	DEL	A	A	-	rs35015855		TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr12:78400665delA	uc001syp.2	+	8	1520	c.1347delA	c.(1345-1347)CCAfs	p.P449fs	NAV3_uc001syo.2_Frame_Shift_Del_p.P449fs	NM_014903	NP_055718	Q8IVL0	NAV3_HUMAN	neuron navigator 3	449						nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			large_intestine(6)|ovary(5)|lung(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	17						TGGCCCCTCCAAAAGCTGGAA	0.398			NA								HNSCC(70;0.22)			34	59	---	---	---	---	NA	NA	NA	NA	NA
ARHGEF7	8874	broad.mit.edu	37	13	111767915	111767915	+	Frame_Shift_Del	DEL	G	G	-	rs144455445		TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr13:111767915delG	uc001vrs.2	+	1	292	c.42delG	c.(40-42)CTGfs	p.L14fs	ARHGEF7_uc001vrr.2_Frame_Shift_Del_p.L14fs|ARHGEF7_uc001vrt.2_Frame_Shift_Del_p.L14fs	NM_001113511	NP_001106983	Q14155	ARHG7_HUMAN	PAK-interacting exchange factor beta isoform c	14	CH.				apoptosis|epidermal growth factor receptor signaling pathway|induction of apoptosis by extracellular signals|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	protein binding|Rho guanyl-nucleotide exchange factor activity			ovary(2)|skin(2)|pancreas(1)|lung(1)|kidney(1)	7	all_lung(23;3.96e-05)|Lung NSC(43;0.00156)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Medulloblastoma(90;0.163)		BRCA - Breast invasive adenocarcinoma(86;0.188)			TCATCACTCTGGGGGTGCTGG	0.682			NA											18	47	---	---	---	---	NA	NA	NA	NA	NA
CPNE6	9362	broad.mit.edu	37	14	24546933	24546933	+	Frame_Shift_Del	DEL	C	C	-			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr14:24546933delC	uc001wll.2	+	16	1767	c.1668delC	c.(1666-1668)AGCfs	p.S556fs	CPNE6_uc010tnv.1_Frame_Shift_Del_p.S611fs|CPNE6_uc001wlm.2_Frame_Shift_Del_p.S381fs|CPNE6_uc001wln.2_3'UTR	NM_006032	NP_006023	O95741	CPNE6_HUMAN	copine 6	556					lipid metabolic process|nervous system development|synaptic transmission|vesicle-mediated transport		calcium ion binding|transporter activity			skin(2)|ovary(1)	3				GBM - Glioblastoma multiforme(265;0.0184)		CCAGCCCTAGCCCGTGACTGC	0.657			NA											9	50	---	---	---	---	NA	NA	NA	NA	NA
SYNE2	23224	broad.mit.edu	37	14	64606758	64606758	+	Frame_Shift_Del	DEL	G	G	-			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr14:64606758delG	uc001xgm.2	+	80	15173	c.14943delG	c.(14941-14943)TTGfs	p.L4981fs	SYNE2_uc001xgl.2_Frame_Shift_Del_p.L4981fs|SYNE2_uc010apy.2_Frame_Shift_Del_p.L1366fs|SYNE2_uc001xgn.2_5'UTR|SYNE2_uc001xgo.2_5'Flank	NM_015180	NP_055995	Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	4981	Spectrin 1.|Cytoplasmic (Potential).				centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			ovary(8)|breast(4)|central_nervous_system(1)|pancreas(1)	14				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)		CTCAGGACTTGGATACAATCA	0.358			NA											41	66	---	---	---	---	NA	NA	NA	NA	NA
CSNK1G1	53944	broad.mit.edu	37	15	64499783	64499783	+	Frame_Shift_Del	DEL	C	C	-			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr15:64499783delC	uc002anf.2	-	7	1170	c.690delG	c.(688-690)CGGfs	p.R230fs	CSNK1G1_uc002ane.2_RNA|CSNK1G1_uc002ang.1_Frame_Shift_Del_p.R230fs|CSNK1G1_uc002anh.1_Frame_Shift_Del_p.R230fs|CSNK1G1_uc002anj.2_Frame_Shift_Del_p.R212fs	NM_022048	NP_071331	Q9HCP0	KC1G1_HUMAN	casein kinase 1, gamma 1	230	Protein kinase.				Wnt receptor signaling pathway	cytoplasm	ATP binding|protein serine/threonine kinase activity				0						AATCATCTCTCCGGCTTTGCT	0.453			NA											14	32	---	---	---	---	NA	NA	NA	NA	NA
ZNF319	57567	broad.mit.edu	37	16	58030897	58030897	+	Frame_Shift_Del	DEL	C	C	-			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr16:58030897delC	uc002emx.1	-	2	1896	c.1273delG	c.(1273-1275)GAGfs	p.E425fs		NM_020807	NP_065858	Q9P2F9	ZN319_HUMAN	zinc finger protein 319	425					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						AAGGGCCGCTCGGCCGCGCCG	0.662			NA											17	28	---	---	---	---	NA	NA	NA	NA	NA
WDR7	23335	broad.mit.edu	37	18	54358470	54358471	+	Frame_Shift_Ins	INS	-	-	T			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr18:54358470_54358471insT	uc002lgk.1	+	8	952_953	c.741_742insT	c.(739-744)TCCTTGfs	p.S247fs	WDR7_uc010dpk.1_RNA|WDR7_uc002lgl.1_Frame_Shift_Ins_p.S247fs	NM_015285	NP_056100	Q9Y4E6	WDR7_HUMAN	rabconnectin-3 beta isoform 1	247_248										ovary(2)|skin(1)	3				Lung(128;0.0238)|Colorectal(16;0.0296)		GAGACTATTCCTTGTTGTGTTC	0.401			NA											18	73	---	---	---	---	NA	NA	NA	NA	NA
CDH7	1005	broad.mit.edu	37	18	63547767	63547767	+	Frame_Shift_Del	DEL	G	G	-	rs150661165		TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr18:63547767delG	uc002ljz.2	+	12	2320	c.1995delG	c.(1993-1995)GCGfs	p.A665fs	CDH7_uc002lkb.2_Frame_Shift_Del_p.A665fs	NM_033646	NP_387450	Q9ULB5	CADH7_HUMAN	cadherin 7, type 2 preproprotein	665	Cytoplasmic (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)|pancreas(1)|skin(1)	4		Esophageal squamous(42;0.129)				ACACGGAAGCGTTTGACATGG	0.488			NA											11	43	---	---	---	---	NA	NA	NA	NA	NA
SMARCA4	6597	broad.mit.edu	37	19	11138587	11138588	+	Frame_Shift_Ins	INS	-	-	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr19:11138587_11138588insA	uc002mqf.3	+	24	3627_3628	c.3343_3344insA	c.(3343-3345)TACfs	p.Y1115fs	SMARCA4_uc010dxp.2_Frame_Shift_Ins_p.Y1115fs|SMARCA4_uc010dxo.2_Frame_Shift_Ins_p.Y1115fs|SMARCA4_uc002mqg.1_Frame_Shift_Ins_p.Y1115fs|SMARCA4_uc010dxq.2_Frame_Shift_Ins_p.Y1115fs|SMARCA4_uc010dxr.2_Frame_Shift_Ins_p.Y1115fs|SMARCA4_uc002mqj.3_Frame_Shift_Ins_p.Y1115fs|SMARCA4_uc010dxs.2_Frame_Shift_Ins_p.Y1115fs|SMARCA4_uc010dxt.1_Frame_Shift_Ins_p.Y335fs|SMARCA4_uc002mqh.3_Frame_Shift_Ins_p.Y238fs|SMARCA4_uc002mqi.1_Frame_Shift_Ins_p.Y318fs	NM_003072	NP_003063	P51532	SMCA4_HUMAN	SWI/SNF-related matrix-associated	1115	Helicase C-terminal.				chromatin remodeling|negative regulation of androgen receptor signaling pathway|negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|negative regulation of transcription from RNA polymerase II promoter|nervous system development|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nBAF complex|npBAF complex|nuclear chromatin|SWI/SNF complex|WINAC complex	androgen receptor binding|ATP binding|DNA binding|DNA-dependent ATPase activity|helicase activity|histone acetyl-lysine binding|identical protein binding|p53 binding|protein N-terminus binding|transcription corepressor activity	p.?(2)		lung(29)|ovary(8)|pancreas(7)|large_intestine(5)|central_nervous_system(5)|skin(3)|prostate(3)|breast(2)|adrenal_gland(1)|stomach(1)|liver(1)|autonomic_ganglia(1)|kidney(1)	67		all_lung(6;0.0512)|Lung NSC(9;0.0568)				CATGGAAGATTACTTTGCGTAT	0.465			NA	F|N|Mis		NSCLC				Rhabdoid_Predisposition_syndrome				105	135	---	---	---	---	NA	NA	NA	NA	NA
LDLR	3949	broad.mit.edu	37	19	11238690	11238691	+	Frame_Shift_Del	DEL	GC	GC	-			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	GC	GC	-	-	GC	GC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr19:11238690_11238691delGC	uc002mqk.3	+	16	2486_2487	c.2318_2319delGC	c.(2317-2319)GGCfs	p.G773fs	LDLR_uc010xlk.1_Frame_Shift_Del_p.G773fs|LDLR_uc010xll.1_Frame_Shift_Del_p.G732fs|LDLR_uc010xlm.1_Frame_Shift_Del_p.G626fs|LDLR_uc010xln.1_Frame_Shift_Del_p.G595fs|LDLR_uc010xlo.1_Frame_Shift_Del_p.G605fs|LDLR_uc010dxu.2_5'UTR	NM_000527	NP_000518	P01130	LDLR_HUMAN	low density lipoprotein receptor precursor	773	Extracellular (Potential).				cholesterol homeostasis|cholesterol metabolic process|interspecies interaction between organisms|intestinal cholesterol absorption|low-density lipoprotein particle clearance|receptor-mediated endocytosis	clathrin-coated endocytic vesicle membrane|coated pit|early endosome|endosome membrane|external side of plasma membrane|integral to plasma membrane|low-density lipoprotein particle|lysosome	calcium ion binding|low-density lipoprotein receptor activity|protein binding|very-low-density lipoprotein particle receptor activity			ovary(2)|skin(2)	4		Lung NSC(9;0.000245)|Renal(1328;0.0007)|Hepatocellular(1079;0.0524)		GBM - Glioblastoma multiforme(1328;1.36e-05)|STAD - Stomach adenocarcinoma(1328;0.000766)|Lung(535;0.197)	Methyl aminolevulinate(DB00992)|Porfimer(DB00707)	GCAGCTCTGGGCGACGTTGCTG	0.624	GBM(18;201 575 7820 21545)		NA											14	82	---	---	---	---	NA	NA	NA	NA	NA
PPFIA3	8541	broad.mit.edu	37	19	49646213	49646225	+	Frame_Shift_Del	DEL	GGAGATGGTCTCG	GGAGATGGTCTCG	-			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	GGAGATGGTCTCG	GGAGATGGTCTCG	-	-	GGAGATGGTCTCG	GGAGATGGTCTCG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr19:49646213_49646225delGGAGATGGTCTCG	uc002pmr.2	+	21	3029_3041	c.2697_2709delGGAGATGGTCTCG	c.(2695-2709)CAGGAGATGGTCTCGfs	p.Q899fs	PPFIA3_uc010yai.1_RNA|PPFIA3_uc010yaj.1_RNA|PPFIA3_uc002pms.2_Frame_Shift_Del_p.Q767fs|PPFIA3_uc002pmt.2_Frame_Shift_Del_p.Q47fs	NM_003660	NP_003651	O75145	LIPA3_HUMAN	PTPRF interacting protein alpha 3	899_903	SAM 1.					cell surface|cytoplasm	protein binding			lung(1)	1		all_lung(116;3.16e-06)|Lung NSC(112;6.25e-06)|all_neural(266;0.0189)|Ovarian(192;0.0392)		all cancers(93;2.36e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.000203)|GBM - Glioblastoma multiforme(486;0.00307)|Epithelial(262;0.00677)		TCGCCATCCAGGAGATGGTCTCGCTCACCTCGC	0.648			NA											24	97	---	---	---	---	NA	NA	NA	NA	NA
ZSCAN1	284312	broad.mit.edu	37	19	58565262	58565268	+	Frame_Shift_Del	DEL	CCCGGGA	CCCGGGA	-	rs144536843	byFrequency	TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	CCCGGGA	CCCGGGA	-	-	CCCGGGA	CCCGGGA	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr19:58565262_58565268delCCCGGGA	uc002qrc.1	+	6	1317_1323	c.1070_1076delCCCGGGA	c.(1069-1077)CCCCGGGAGfs	p.P357fs		NM_182572	NP_872378	Q8NBB4	ZSCA1_HUMAN	zinc finger and SCAN domain containing 1	357_359					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2		Colorectal(82;5.46e-05)|all_neural(62;0.0182)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0152)		AGCAAGGGCCCCCGGGAGTCCGTCCCA	0.657			NA											24	38	---	---	---	---	NA	NA	NA	NA	NA
NRXN1	9378	broad.mit.edu	37	2	51255156	51255157	+	Frame_Shift_Del	DEL	CG	CG	-			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	CG	CG	-	-	CG	CG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr2:51255156_51255157delCG	uc010fbq.2	-	2	1732_1733	c.255_256delCG	c.(253-258)CGCGGCfs	p.R85fs	NRXN1_uc002rxe.3_Frame_Shift_Del_p.R85fs|NRXN1_uc002rxd.1_Frame_Shift_Del_p.R85fs	NM_001135659	NP_001129131	P58400	NRX1B_HUMAN	neurexin 1 isoform alpha2 precursor	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment_150					angiogenesis|neuron cell-cell adhesion|neuronal signal transduction	cell surface|endocytic vesicle|integral to membrane|presynaptic membrane	cell adhesion molecule binding|receptor binding			ovary(2)	2		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.192)	Lung(47;0.0813)|LUSC - Lung squamous cell carcinoma(58;0.116)			AGGCGGCCGCCGCGCGTCAGAA	0.663			NA											12	10	---	---	---	---	NA	NA	NA	NA	NA
SEMG1	6406	broad.mit.edu	37	20	43836371	43836371	+	Frame_Shift_Del	DEL	G	G	-			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr20:43836371delG	uc002xni.2	+	2	490	c.433delG	c.(433-435)GATfs	p.D145fs	SEMG1_uc002xnj.2_Frame_Shift_Del_p.D145fs|SEMG2_uc010ggz.2_Intron|SEMG1_uc002xnh.2_Frame_Shift_Del_p.D145fs	NM_003007	NP_002998	P04279	SEMG1_HUMAN	semenogelin I preproprotein	145					insemination|sexual reproduction	extracellular space|stored secretory granule	structural molecule activity			skin(2)	2		Myeloproliferative disorder(115;0.0122)				TCCTTCTCAAGATCAGGGGAA	0.418			NA											25	57	---	---	---	---	NA	NA	NA	NA	NA
SRGAP3	9901	broad.mit.edu	37	3	9100069	9100069	+	Frame_Shift_Del	DEL	C	C	-			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr3:9100069delC	uc003brf.1	-	7	1565	c.889delG	c.(889-891)GAAfs	p.E297fs	SRGAP3_uc003brg.1_Frame_Shift_Del_p.E297fs|SRGAP3_uc003bri.1_RNA|SRGAP3_uc003brj.1_Frame_Shift_Del_p.E157fs	NM_014850	NP_055665	O43295	SRGP2_HUMAN	SLIT-ROBO Rho GTPase activating protein 3	297					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|protein binding		SRGAP3/RAF1(4)	central_nervous_system(4)|skin(3)|urinary_tract(1)|breast(1)	9				OV - Ovarian serous cystadenocarcinoma(96;0.0563)		TCCAGCCCTTCGTGGCGAGAG	0.552			NA	T	RAF1	pilocytic astrocytoma								38	131	---	---	---	---	NA	NA	NA	NA	NA
MKRN2	23609	broad.mit.edu	37	3	12623348	12623349	+	Frame_Shift_Ins	INS	-	-	C			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr3:12623348_12623349insC	uc003bxd.2	+	7	1066_1067	c.1010_1011insC	c.(1009-1011)TGCfs	p.C337fs	MKRN2_uc003bxe.2_Frame_Shift_Ins_p.C335fs|MKRN2_uc011aus.1_Frame_Shift_Ins_p.C294fs	NM_014160	NP_054879	Q9H000	MKRN2_HUMAN	makorin ring finger protein 2	337	C3H1-type 4.					intracellular	ligase activity|nucleic acid binding|zinc ion binding				0						AAGGGGACCTGCCCATTTGGAA	0.495			NA											37	113	---	---	---	---	NA	NA	NA	NA	NA
ROBO1	6091	broad.mit.edu	37	3	78988050	78988050	+	Frame_Shift_Del	DEL	G	G	-			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr3:78988050delG	uc003dqe.2	-	4	408	c.200delC	c.(199-201)CCAfs	p.P67fs	ROBO1_uc003dqb.2_Frame_Shift_Del_p.P28fs|ROBO1_uc003dqc.2_Frame_Shift_Del_p.P28fs|ROBO1_uc003dqd.2_Frame_Shift_Del_p.P28fs	NM_002941	NP_002932	Q9Y6N7	ROBO1_HUMAN	roundabout 1 isoform a	67	Extracellular (Potential).				activation of caspase activity|axon midline choice point recognition|cell migration involved in sprouting angiogenesis|chemorepulsion involved in postnatal olfactory bulb interneuron migration|homophilic cell adhesion|negative regulation of chemokine-mediated signaling pathway|negative regulation of mammary gland epithelial cell proliferation|negative regulation of negative chemotaxis|positive regulation of axonogenesis|Roundabout signaling pathway	cell surface|cytoplasm|integral to plasma membrane	axon guidance receptor activity|identical protein binding|LRR domain binding			large_intestine(2)	2		Lung SC(41;0.0257)|Lung NSC(201;0.0439)		LUSC - Lung squamous cell carcinoma(21;0.008)|Epithelial(33;0.00999)|Lung(72;0.0177)|BRCA - Breast invasive adenocarcinoma(55;0.0274)		AATGCGAGGTGGAAAATCTTC	0.433			NA											9	42	---	---	---	---	NA	NA	NA	NA	NA
DBR1	51163	broad.mit.edu	37	3	137880881	137880881	+	Frame_Shift_Del	DEL	C	C	-			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr3:137880881delC	uc003erv.2	-	8	1621	c.1485delG	c.(1483-1485)GGGfs	p.G495fs	DBR1_uc003eru.2_Frame_Shift_Del_p.G444fs|DBR1_uc003ert.2_Frame_Shift_Del_p.G263fs	NM_016216	NP_057300	Q9UK59	DBR1_HUMAN	debranching enzyme homolog 1	495						nucleus	metal ion binding|RNA lariat debranching enzyme activity				0						ACTCCACAGTCCCACCAGGTT	0.453			NA											23	83	---	---	---	---	NA	NA	NA	NA	NA
DHFR	1719	broad.mit.edu	37	5	79950244	79950244	+	Frame_Shift_Del	DEL	T	T	-			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr5:79950244delT	uc003kgy.1	-	1	557	c.65delA	c.(64-66)GACfs	p.D22fs	MSH3_uc003kgz.2_5'Flank|DHFR_uc011ctl.1_Frame_Shift_Del_p.D102fs|DHFR_uc011ctm.1_5'UTR|DHFR_uc010jap.1_RNA|DHFR_uc003kgx.1_Frame_Shift_Del_p.D171fs	NM_000791	NP_000782	P00374	DYR_HUMAN	dihydrofolate reductase	22	DHFR.|NADP.				folic acid metabolic process|glycine biosynthetic process|nucleotide biosynthetic process|one-carbon metabolic process|regulation of transcription involved in G1/S phase of mitotic cell cycle|response to methotrexate|tetrahydrofolate metabolic process	cytosol	dihydrofolate reductase activity|drug binding|folate reductase activity|NADP binding				0		Lung NSC(167;0.00475)|all_lung(232;0.00502)|Ovarian(174;0.0261)		OV - Ovarian serous cystadenocarcinoma(54;2.69e-46)|Epithelial(54;7.49e-41)|all cancers(79;1.54e-35)	Dapsone(DB00250)|Dimethyl sulfoxide(DB01093)|Lamotrigine(DB00555)|Methotrexate(DB00563)|NADH(DB00157)|Pemetrexed(DB00642)|Proguanil(DB01131)|Pyrimethamine(DB00205)|Trimethoprim(DB00440)|Trimetrexate(DB01157)	CCAGGGCAGGTCCCCGTTCTT	0.682			NA											14	36	---	---	---	---	NA	NA	NA	NA	NA
FAM172A	83989	broad.mit.edu	37	5	92956752	92956757	+	In_Frame_Del	DEL	TGGTCT	TGGTCT	-			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	TGGTCT	TGGTCT	-	-	TGGTCT	TGGTCT	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr5:92956752_92956757delTGGTCT	uc010jbd.2	-	11	1394_1399	c.1187_1192delAGACCA	c.(1186-1194)AAGACCAGC>AGC	p.KT396del	FAM172A_uc011cuf.1_In_Frame_Del_p.KT350del|FAM172A_uc011cug.1_In_Frame_Del_p.KT286del|FAM172A_uc011cuh.1_In_Frame_Del_p.KT249del|FAM172A_uc011cui.1_RNA|FAM172A_uc011cuj.1_3'UTR|MIR2277_hsa-mir-2277|MI0011284_5'Flank	NM_032042	NP_114431	Q8WUF8	F172A_HUMAN	hypothetical protein LOC83989 isoform 1	396_397						endoplasmic reticulum|extracellular region					0						TTCAGGGAGCTGGTCTTGGCCTCTGA	0.597			NA											8	59	---	---	---	---	NA	NA	NA	NA	NA
HSPA4	3308	broad.mit.edu	37	5	132437501	132437501	+	Frame_Shift_Del	DEL	A	A	-			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr5:132437501delA	uc003kyj.2	+	17	2369	c.2088delA	c.(2086-2088)CCAfs	p.P696fs		NM_002154	NP_002145	P34932	HSP74_HUMAN	heat shock 70kDa protein 4	696					cellular chaperone-mediated protein complex assembly|protein import into mitochondrial outer membrane|response to unfolded protein	cytoplasm|nucleus	ATP binding			lung(1)|breast(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			AAGAACGACCAAAATTATTTG	0.343	Colon(114;1299 1588 6063 12302 48757)		NA											8	24	---	---	---	---	NA	NA	NA	NA	NA
GUSB	2990	broad.mit.edu	37	7	65439604	65439604	+	Frame_Shift_Del	DEL	G	G	-			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr7:65439604delG	uc003tun.2	-	7	1229	c.1153delC	c.(1153-1155)CACfs	p.H385fs	GUSB_uc011kdt.1_Frame_Shift_Del_p.H239fs	NM_000181	NP_000172	P08236	BGLR_HUMAN	glucuronidase, beta precursor	385					glycosaminoglycan catabolic process	lysosome	beta-glucuronidase activity|cation binding				0						TAGGGGTAGTGGCTGGTACGG	0.592			NA											17	85	---	---	---	---	NA	NA	NA	NA	NA
FSCN3	29999	broad.mit.edu	37	7	127235724	127235726	+	In_Frame_Del	DEL	GCA	GCA	-			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	GCA	GCA	-	-	GCA	GCA	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr7:127235724_127235726delGCA	uc003vmd.1	+	2	727_729	c.508_510delGCA	c.(508-510)GCAdel	p.A171del	FSCN3_uc003vmc.1_In_Frame_Del_p.A126del|FSCN3_uc011kog.1_RNA|FSCN3_uc011koh.1_In_Frame_Del_p.A37del|FSCN3_uc010llc.1_In_Frame_Del_p.A171del	NM_020369	NP_065102	Q9NQT6	FSCN3_HUMAN	fascin 3	171						actin cytoskeleton|cytoplasm	actin filament binding|protein binding, bridging			ovary(1)	1						CTGGGTGGACGCAGCAGTTCCCT	0.611			NA											12	79	---	---	---	---	NA	NA	NA	NA	NA
CSMD1	64478	broad.mit.edu	37	8	3265561	3265561	+	Frame_Shift_Del	DEL	C	C	-			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr8:3265561delC	uc011kwk.1	-	14	2324	c.1934delG	c.(1933-1935)GGCfs	p.G645fs	CSMD1_uc011kwj.1_Frame_Shift_Del_p.G37fs	NM_033225	NP_150094	Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1 precursor	645	Extracellular (Potential).|CUB 4.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		GTCAGAAATGCCATCATCCTT	0.458			NA											10	13	---	---	---	---	NA	NA	NA	NA	NA
KLF10	7071	broad.mit.edu	37	8	103664486	103664487	+	Frame_Shift_Del	DEL	TA	TA	-			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	TA	TA	-	-	TA	TA	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr8:103664486_103664487delTA	uc011lhk.1	-	2	329_330	c.175_176delTA	c.(175-177)TACfs	p.Y59fs	KLF10_uc011lhj.1_Frame_Shift_Del_p.Y48fs	NM_005655	NP_005646	Q13118	KLF10_HUMAN	Kruppel-like factor 10 isoform a	59					cell proliferation|cell-cell signaling|negative regulation of cell proliferation|negative regulation of transcription from RNA polymerase II promoter|skeletal system development|transforming growth factor beta receptor signaling pathway	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0	all_epithelial(15;5.63e-07)|Lung NSC(17;8.18e-05)|all_lung(17;0.000169)		OV - Ovarian serous cystadenocarcinoma(57;0.000112)|STAD - Stomach adenocarcinoma(118;0.0826)			GTTTTCAACGTATTTCTTAAAA	0.391	Esophageal Squamous(16;495 519 2144 16528 44005)		NA									OREG0018913	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	25	85	---	---	---	---	NA	NA	NA	NA	NA
ENPP2	5168	broad.mit.edu	37	8	120577193	120577193	+	Frame_Shift_Del	DEL	C	C	-			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr8:120577193delC	uc003yot.1	-	23	2220	c.2134delG	c.(2134-2136)GTCfs	p.V712fs	ENPP2_uc011lic.1_Frame_Shift_Del_p.V250fs|ENPP2_uc003yor.1_Frame_Shift_Del_p.V347fs|ENPP2_uc003yos.1_Frame_Shift_Del_p.V764fs|ENPP2_uc010mdd.1_Frame_Shift_Del_p.V737fs	NM_001040092	NP_001035181	Q13822	ENPP2_HUMAN	autotaxin isoform 2 preproprotein	712					cellular component movement|chemotaxis|G-protein coupled receptor protein signaling pathway|immune response|phosphate metabolic process|phosphatidylcholine catabolic process|regulation of cell migration	extracellular space|integral to plasma membrane	alkylglycerophosphoethanolamine phosphodiesterase activity|calcium ion binding|lysophospholipase activity|nucleic acid binding|nucleotide diphosphatase activity|phosphodiesterase I activity|polysaccharide binding|scavenger receptor activity|transcription factor binding|zinc ion binding			ovary(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)|large_intestine(1)|kidney(1)	7	Lung NSC(37;5.03e-06)|Ovarian(258;0.0249)|Hepatocellular(40;0.161)		STAD - Stomach adenocarcinoma(47;0.00185)			TAATTCCAGACCCCTGTGCAA	0.383	Melanoma(20;305 879 2501 4818 31020)		NA											7	27	---	---	---	---	NA	NA	NA	NA	NA
TESK1	7016	broad.mit.edu	37	9	35606843	35606843	+	Frame_Shift_Del	DEL	G	G	-			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr9:35606843delG	uc003zxa.2	+	4	736	c.400delG	c.(400-402)GGGfs	p.G134fs	TESK1_uc003zwz.1_RNA|TESK1_uc010mks.2_Frame_Shift_Del_p.M1fs	NM_006285	NP_006276	Q15569	TESK1_HUMAN	testis-specific protein kinase 1	134	Protein kinase.				cell junction assembly|spermatogenesis	cytosol	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			stomach(2)|breast(2)|lung(1)|ovary(1)|skin(1)	7			Lung(28;0.00276)|LUSC - Lung squamous cell carcinoma(32;0.00418)|STAD - Stomach adenocarcinoma(86;0.194)			GTATATGAATGGGGGGACATT	0.383			NA											13	74	---	---	---	---	NA	NA	NA	NA	NA
ZNF782	158431	broad.mit.edu	37	9	99581246	99581246	+	Frame_Shift_Del	DEL	G	G	-	rs35483372		TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chr9:99581246delG	uc004awp.1	-	6	1340	c.1059delC	c.(1057-1059)TTCfs	p.F353fs	ZNF782_uc011lup.1_Frame_Shift_Del_p.F221fs	NM_001001662	NP_001001662	Q6ZMW2	ZN782_HUMAN	zinc finger protein 782	353	C2H2-type 3; degenerate.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Acute lymphoblastic leukemia(62;0.0527)				GATGTACACTGAAAGTTGACT	0.408			NA											28	91	---	---	---	---	NA	NA	NA	NA	NA
DCAF8L1	139425	broad.mit.edu	37	X	27997961	27997962	+	Frame_Shift_Del	DEL	CG	CG	-			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	CG	CG	-	-	CG	CG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chrX:27997961_27997962delCG	uc004dbx.1	-	1	1605_1606	c.1490_1491delCG	c.(1489-1491)GCGfs	p.A497fs		NM_001017930	NP_001017930	A6NGE4	DC8L1_HUMAN	DDB1 and CUL4 associated factor 8-like 1	497	WD 7.									ovary(3)|skin(1)	4						GGCCACTGGTCGCCAACACAGG	0.485			NA											11	32	---	---	---	---	NA	NA	NA	NA	NA
IRS4	8471	broad.mit.edu	37	X	107977860	107977861	+	Frame_Shift_Ins	INS	-	-	A			TCGA-67-3771-01A-01D-1040-01	TCGA-67-3771-10A-01D-1040-01	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	a715d783-38f1-4f6d-991b-983fb907cc9f	24f1a1ea-733d-45b3-a51b-073807143f78	g.chrX:107977860_107977861insA	uc004eoc.2	-	1	1747_1748	c.1714_1715insT	c.(1714-1716)GGTfs	p.G572fs		NM_003604	NP_003595	O14654	IRS4_HUMAN	insulin receptor substrate 4	572						plasma membrane	insulin receptor binding|SH3/SH2 adaptor activity|signal transducer activity			ovary(4)|large_intestine(2)|lung(1)|breast(1)|skin(1)|pancreas(1)	10						TCCCTGGCCACCACCTGAGCCA	0.629			NA											68	166	---	---	---	---	NA	NA	NA	NA	NA