Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	ACHILLES_Top_Genes	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
MYOM3	127294	broad.mit.edu	37	1	24419571	24419571	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5774-01A-01D-1625-08	TCGA-64-5774-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	df5957d5-20d3-483e-990b-d6369fb990b8	4fb568ce-a4be-46c5-862b-5c681936f30b	g.chr1:24419571C>A	uc001bin.3	-	10	1119	c.956G>T	c.(955-957)CGG>CTG	p.R319L	MYOM3_uc001bim.3_5'UTR|MYOM3_uc001bio.2_Missense_Mutation_p.R319L|MYOM3_uc001bip.1_5'UTR	NM_152372	NP_689585	Q5VTT5	MYOM3_HUMAN	myomesin family, member 3	319	Ig-like C2-type 2.									skin(2)|ovary(1)	3		Colorectal(325;3.55e-05)|Renal(390;0.000703)|Lung NSC(340;0.001)|all_lung(284;0.0014)|Ovarian(437;0.00351)|Breast(348;0.0126)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;5.31e-24)|Colorectal(126;7.52e-08)|COAD - Colon adenocarcinoma(152;4.01e-06)|GBM - Glioblastoma multiforme(114;4.36e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00108)|KIRC - Kidney renal clear cell carcinoma(1967;0.00404)|STAD - Stomach adenocarcinoma(196;0.00966)|READ - Rectum adenocarcinoma(331;0.0678)|Lung(427;0.153)		GAGGATCTTCCGACGTCTCGA	0.622			NA											18	3					6.33239e-15	9.59909e-15	0.010504	1	0
ZMYM1	79830	broad.mit.edu	37	1	35570213	35570213	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5774-01A-01D-1625-08	TCGA-64-5774-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	df5957d5-20d3-483e-990b-d6369fb990b8	4fb568ce-a4be-46c5-862b-5c681936f30b	g.chr1:35570213G>T	uc001bym.2	+	7	798	c.650G>T	c.(649-651)TGC>TTC	p.C217F	ZMYM1_uc009vus.1_RNA|ZMYM1_uc001byn.2_Missense_Mutation_p.C217F|ZMYM1_uc010ohu.1_Missense_Mutation_p.C217F|ZMYM1_uc001byo.2_5'UTR|ZMYM1_uc009vut.2_Missense_Mutation_p.C142F	NM_024772	NP_079048	Q5SVZ6	ZMYM1_HUMAN	zinc finger, MYM domain containing 1	217	MYM-type 3.					nucleus	nucleic acid binding|protein dimerization activity|zinc ion binding				0		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				AGTAATGCCTGCCTTTCAAAG	0.358			NA											29	10					6.07407e-21	1.00013e-20	0.007291	1	0
PGM1	5236	broad.mit.edu	37	1	64114274	64114274	+	Missense_Mutation	SNP	G	G	C			TCGA-64-5774-01A-01D-1625-08	TCGA-64-5774-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	df5957d5-20d3-483e-990b-d6369fb990b8	4fb568ce-a4be-46c5-862b-5c681936f30b	g.chr1:64114274G>C	uc001dbh.2	+	8	1444	c.1231G>C	c.(1231-1233)GAC>CAC	p.D411H	PGM1_uc010ooy.1_Missense_Mutation_p.D214H|PGM1_uc010ooz.1_Missense_Mutation_p.D429H	NM_002633	NP_002624	P36871	PGM1_HUMAN	phosphoglucomutase 1	411					cellular calcium ion homeostasis|galactose catabolic process|glucose 1-phosphate metabolic process|glycogen biosynthetic process|glycogen catabolic process	cytosol	magnesium ion binding|phosphoglucomutase activity			ovary(2)|kidney(1)	3						GAGTGTGGAGGACATTCTCAA	0.562			NA											3	44					0	0	0.004672	0	0
CELF3	11189	broad.mit.edu	37	1	151677546	151677546	+	Silent	SNP	G	G	T			TCGA-64-5774-01A-01D-1625-08	TCGA-64-5774-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	df5957d5-20d3-483e-990b-d6369fb990b8	4fb568ce-a4be-46c5-862b-5c681936f30b	g.chr1:151677546G>T	uc001eys.1	-	12	2163	c.1369C>A	c.(1369-1371)CGG>AGG	p.R457R	CELF3_uc010pdh.1_Silent_p.R243R|CELF3_uc001eyr.2_Silent_p.R456R|CELF3_uc009wmy.2_Silent_p.R407R|CELF3_uc009wmx.1_Silent_p.R456R	NM_007185	NP_009116	Q5SZQ8	CELF3_HUMAN	trinucleotide repeat containing 4	457	RRM 3.				nuclear mRNA splicing, via spliceosome|regulation of alternative nuclear mRNA splicing, via spliceosome	cytoplasm|nucleus	mRNA binding|nucleotide binding			ovary(1)|central_nervous_system(1)	2						TCCTTAGGCCGCTTTAGCTGG	0.632			NA											25	36					2.41591e-17	3.84532e-17	0.004656	1	0
RXFP4	339403	broad.mit.edu	37	1	155912009	155912009	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5774-01A-01D-1625-08	TCGA-64-5774-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	df5957d5-20d3-483e-990b-d6369fb990b8	4fb568ce-a4be-46c5-862b-5c681936f30b	g.chr1:155912009C>A	uc010pgs.1	+	1	530	c.509C>A	c.(508-510)GCC>GAC	p.A170D		NM_181885	NP_871001	Q8TDU9	RL3R2_HUMAN	relaxin 3 receptor 2	170	Helical; Name=4; (Potential).					integral to membrane|plasma membrane	angiotensin type II receptor activity				0	Hepatocellular(266;0.133)|all_hematologic(923;0.145)|all_neural(408;0.195)					GCGGCGGCTGCCCTGGTGACG	0.682			NA											22	76					3.28513e-13	4.75348e-13	0.021523	1	0
SPTA1	6708	broad.mit.edu	37	1	158605807	158605807	+	Silent	SNP	T	T	A			TCGA-64-5774-01A-01D-1625-08	TCGA-64-5774-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	df5957d5-20d3-483e-990b-d6369fb990b8	4fb568ce-a4be-46c5-862b-5c681936f30b	g.chr1:158605807T>A	uc001fst.1	-	38	5527	c.5328A>T	c.(5326-5328)GCA>GCT	p.A1776A		NM_003126	NP_003117	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1	1776	Spectrin 17.				actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|breast(1)	8	all_hematologic(112;0.0378)					TCAGCTTCTCTGCCATATCCA	0.507			NA											88	126					0	0	0.01441	0	0
OR6N2	81442	broad.mit.edu	37	1	158747003	158747003	+	Missense_Mutation	SNP	A	A	C			TCGA-64-5774-01A-01D-1625-08	TCGA-64-5774-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	df5957d5-20d3-483e-990b-d6369fb990b8	4fb568ce-a4be-46c5-862b-5c681936f30b	g.chr1:158747003A>C	uc010pir.1	-	1	423	c.423T>G	c.(421-423)TGT>TGG	p.C141W		NM_001005278	NP_001005278	Q8NGY6	OR6N2_HUMAN	olfactory receptor, family 6, subfamily N,	141	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_hematologic(112;0.0378)					CCATCTTGGCACAGAGTGTGG	0.502			NA											16	59					0	0	0.006122	0	0
HMCN1	83872	broad.mit.edu	37	1	185985107	185985107	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5774-01A-01D-1625-08	TCGA-64-5774-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	df5957d5-20d3-483e-990b-d6369fb990b8	4fb568ce-a4be-46c5-862b-5c681936f30b	g.chr1:185985107G>T	uc001grq.1	+	32	5156	c.4927G>T	c.(4927-4929)GGC>TGC	p.G1643C		NM_031935	NP_114141	Q96RW7	HMCN1_HUMAN	hemicentin 1 precursor	1643	Ig-like C2-type 14.				response to stimulus|visual perception	basement membrane	calcium ion binding			ovary(22)|skin(1)	23						AATGATTGAAGGCAACTTGGC	0.403			NA											38	50					5.73237e-09	7.55091e-09	0.00623	1	0
TMEM81	388730	broad.mit.edu	37	1	205052919	205052919	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5774-01A-01D-1625-08	TCGA-64-5774-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	df5957d5-20d3-483e-990b-d6369fb990b8	4fb568ce-a4be-46c5-862b-5c681936f30b	g.chr1:205052919C>A	uc001hbt.2	-	1	670	c.530G>T	c.(529-531)GGG>GTG	p.G177V		NM_203376	NP_976310	Q6P7N7	TMM81_HUMAN	transmembrane protein 81 precursor	177	Extracellular (Potential).					integral to membrane					0	all_cancers(21;0.144)|Breast(84;0.0437)		BRCA - Breast invasive adenocarcinoma(75;0.0923)			GACCCTCAACCCAAAATAGAG	0.418			NA											26	40					1.42536e-11	1.95858e-11	0.004656	1	0
KCNH1	3756	broad.mit.edu	37	1	211276891	211276891	+	Missense_Mutation	SNP	G	G	A			TCGA-64-5774-01A-01D-1625-08	TCGA-64-5774-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	df5957d5-20d3-483e-990b-d6369fb990b8	4fb568ce-a4be-46c5-862b-5c681936f30b	g.chr1:211276891G>A	uc001hib.2	-	3	427	c.257C>T	c.(256-258)ACA>ATA	p.T86I	KCNH1_uc001hic.2_Missense_Mutation_p.T86I	NM_172362	NP_758872	O95259	KCNH1_HUMAN	potassium voltage-gated channel, subfamily H,	86	Cytoplasmic (Potential).|PAS.				myoblast fusion|regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	calmodulin binding|delayed rectifier potassium channel activity|two-component sensor activity			ovary(4)|central_nervous_system(1)	5				OV - Ovarian serous cystadenocarcinoma(81;0.0109)|all cancers(67;0.141)|Epithelial(68;0.185)		GTTCTCAAATGTTTGCCGCAC	0.333			NA											15	57					0	0	0.00499	0	0
C1orf65	164127	broad.mit.edu	37	1	223567018	223567018	+	Silent	SNP	C	C	A			TCGA-64-5774-01A-01D-1625-08	TCGA-64-5774-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	df5957d5-20d3-483e-990b-d6369fb990b8	4fb568ce-a4be-46c5-862b-5c681936f30b	g.chr1:223567018C>A	uc001hoa.2	+	1	304	c.201C>A	c.(199-201)ACC>ACA	p.T67T		NM_152610	NP_689823	Q8N715	CA065_HUMAN	hypothetical protein LOC164127	67										central_nervous_system(1)|skin(1)	2				GBM - Glioblastoma multiforme(131;0.0704)		GTTCGTTCACCCCGCGGCCTC	0.721			NA											10	12					6.40141e-05	7.27779e-05	0.010729	1	0
OBSCN	84033	broad.mit.edu	37	1	228554800	228554800	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5774-01A-01D-1625-08	TCGA-64-5774-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	df5957d5-20d3-483e-990b-d6369fb990b8	4fb568ce-a4be-46c5-862b-5c681936f30b	g.chr1:228554800G>T	uc009xez.1	+	86	19596	c.19552G>T	c.(19552-19554)GCG>TCG	p.A6518S	OBSCN_uc001hsr.1_Missense_Mutation_p.A1147S	NM_001098623	NP_001092093	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and	6518	Protein kinase 1.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			stomach(8)|large_intestine(7)|breast(5)|ovary(4)|skin(2)|central_nervous_system(1)|pancreas(1)	28		Prostate(94;0.0405)				CATCCTGGCCGCGCTGAGCCA	0.612			NA											5	6					4.096e-09	5.43289e-09	0.001168	1	0
MTR	4548	broad.mit.edu	37	1	237057847	237057847	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5774-01A-01D-1625-08	TCGA-64-5774-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	df5957d5-20d3-483e-990b-d6369fb990b8	4fb568ce-a4be-46c5-862b-5c681936f30b	g.chr1:237057847G>T	uc001hyi.3	+	30	3818	c.3395G>T	c.(3394-3396)CGG>CTG	p.R1132L	MTR_uc010pxw.1_Missense_Mutation_p.R725L|MTR_uc010pxx.1_Missense_Mutation_p.R1081L|MTR_uc010pxy.1_Missense_Mutation_p.R986L	NM_000254	NP_000245	Q99707	METH_HUMAN	5-methyltetrahydrofolate-homocysteine	1132	AdoMet activation.				nervous system development|xenobiotic metabolic process	cytosol	cobalamin binding|homocysteine S-methyltransferase activity|methionine synthase activity|protein binding|zinc ion binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3	Ovarian(103;0.0634)|Breast(184;0.221)	all_cancers(173;2.79e-22)|all_epithelial(177;4.84e-14)|Breast(1374;0.00123)|Prostate(94;0.0181)|Lung SC(1967;0.0262)|Acute lymphoblastic leukemia(190;0.117)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)	KIRC - Kidney renal clear cell carcinoma(1967;0.248)	Hydroxocobalamin(DB00200)|L-Methionine(DB00134)|Tetrahydrofolic acid(DB00116)	CTGGGGGACCGGCTGGCAGAG	0.607			NA											13	28					2.62699e-14	3.91996e-14	0.003163	1	0
OR2T2	401992	broad.mit.edu	37	1	248616264	248616264	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5774-01A-01D-1625-08	TCGA-64-5774-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	df5957d5-20d3-483e-990b-d6369fb990b8	4fb568ce-a4be-46c5-862b-5c681936f30b	g.chr1:248616264C>A	uc001iek.1	+	1	166	c.166C>A	c.(166-168)CTC>ATC	p.L56I		NM_001004136	NP_001004136	Q6IF00	OR2T2_HUMAN	olfactory receptor, family 2, subfamily T,	56	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			GGACTCCCGCCTCCACACACC	0.512			NA											4	86					5.9392e-07	7.56258e-07	0.001168	1	0
CUBN	8029	broad.mit.edu	37	10	16982064	16982064	+	Missense_Mutation	SNP	T	T	C			TCGA-64-5774-01A-01D-1625-08	TCGA-64-5774-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	df5957d5-20d3-483e-990b-d6369fb990b8	4fb568ce-a4be-46c5-862b-5c681936f30b	g.chr10:16982064T>C	uc001ioo.2	-	37	5567	c.5515A>G	c.(5515-5517)AGC>GGC	p.S1839G		NM_001081	NP_001072	O60494	CUBN_HUMAN	cubilin precursor	1839	CUB 12.				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			ovary(9)|breast(4)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|kidney(1)	19					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	CCCGTGCCGCTGCCAGAACCA	0.413			NA											116	39					0	0	0.01441	0	0
ARHGAP21	57584	broad.mit.edu	37	10	24874156	24874156	+	Missense_Mutation	SNP	G	G	A			TCGA-64-5774-01A-01D-1625-08	TCGA-64-5774-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	df5957d5-20d3-483e-990b-d6369fb990b8	4fb568ce-a4be-46c5-862b-5c681936f30b	g.chr10:24874156G>A	uc001isb.2	-	26	5549	c.5062C>T	c.(5062-5064)CGG>TGG	p.R1688W	ARHGAP21_uc010qdb.1_RNA	NM_020824	NP_065875	Q5T5U3	RHG21_HUMAN	Rho GTPase activating protein 21	1687	Interaction with CTNNA1.				signal transduction	cell junction|cytoplasmic vesicle membrane|cytoskeleton|Golgi membrane	GTPase activator activity|protein binding			ovary(7)|pancreas(1)	8						AGCTGTCTCCGGCTATCTAAA	0.428			NA											17	40					0	0	0.01892	0	0
ZEB1	6935	broad.mit.edu	37	10	31815998	31815998	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5774-01A-01D-1625-08	TCGA-64-5774-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	df5957d5-20d3-483e-990b-d6369fb990b8	4fb568ce-a4be-46c5-862b-5c681936f30b	g.chr10:31815998G>T	uc001ivs.3	+	9	3244	c.3181G>T	c.(3181-3183)GGG>TGG	p.G1061W	ZEB1_uc001ivr.3_Missense_Mutation_p.G843W|ZEB1_uc010qee.1_Missense_Mutation_p.G843W|ZEB1_uc010qef.1_Missense_Mutation_p.G843W|ZEB1_uc001ivt.3_Missense_Mutation_p.G843W|ZEB1_uc001ivu.3_Missense_Mutation_p.G1062W|ZEB1_uc001ivv.3_Missense_Mutation_p.G1041W|ZEB1_uc010qeh.1_Missense_Mutation_p.G994W|ZEB1_uc009xlp.2_Missense_Mutation_p.G1045W	NM_030751	NP_110378	P37275	ZEB1_HUMAN	zinc finger E-box binding homeobox 1 isoform b	1061	Glu-rich (acidic).				cell proliferation|immune response|negative regulation of transcription from RNA polymerase II promoter|positive regulation of neuron differentiation	cytoplasm	E-box binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity|zinc ion binding			ovary(3)|central_nervous_system(2)	5		Prostate(175;0.0156)				aaaaccacaaggggatgagga	0.1	Ovarian(40;423 959 14296 36701 49589)		NA											10	5					9.70103e-10	1.29573e-09	0.008291	1	0
ZNF33A	7581	broad.mit.edu	37	10	38343661	38343661	+	Silent	SNP	T	T	C			TCGA-64-5774-01A-01D-1625-08	TCGA-64-5774-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	df5957d5-20d3-483e-990b-d6369fb990b8	4fb568ce-a4be-46c5-862b-5c681936f30b	g.chr10:38343661T>C	uc001izh.2	+	5	784	c.606T>C	c.(604-606)CAT>CAC	p.H202H	ZNF33A_uc001izg.2_Silent_p.H203H|ZNF33A_uc010qev.1_Silent_p.H209H|ZNF33A_uc001izi.1_Intron	NM_006974	NP_008905	Q06730	ZN33A_HUMAN	zinc finger protein 33A isoform b	202						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)|skin(1)	3						TGAGTCATCATGAGGAGACTT	0.348			NA											19	65					0	0	0.008871	0	0
C10orf84	63877	broad.mit.edu	37	10	120095077	120095077	+	Missense_Mutation	SNP	C	C	T	rs148686616		TCGA-64-5774-01A-01D-1625-08	TCGA-64-5774-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	df5957d5-20d3-483e-990b-d6369fb990b8	4fb568ce-a4be-46c5-862b-5c681936f30b	g.chr10:120095077C>T	uc001ldo.2	-	4	578	c.311G>A	c.(310-312)CGC>CAC	p.R104H	C10orf84_uc010qss.1_Missense_Mutation_p.R104H	NM_022063	NP_071346	Q9H8W3	F204A_HUMAN	hypothetical protein LOC63877	104											0		Colorectal(252;0.101)		all cancers(201;0.0244)		TTTTCTGGAGCGTTTTCTTCT	0.303			NA											22	12					0	0	0.014323	0	0
OR56A3	390083	broad.mit.edu	37	11	5968696	5968696	+	Silent	SNP	C	C	A			TCGA-64-5774-01A-01D-1625-08	TCGA-64-5774-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	df5957d5-20d3-483e-990b-d6369fb990b8	4fb568ce-a4be-46c5-862b-5c681936f30b	g.chr11:5968696C>A	uc010qzt.1	+	1	120	c.120C>A	c.(118-120)CTC>CTA	p.L40L		NM_001003443	NP_001003443	Q8NH54	O56A3_HUMAN	olfactory receptor, family 56, subfamily A,	40	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;9.41e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TCCTTTTCCTCTTGGCCGTAG	0.597			NA											62	18					6.52717e-41	1.29863e-40	0.01441	1	0
TRIM3	10612	broad.mit.edu	37	11	6477727	6477727	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5774-01A-01D-1625-08	TCGA-64-5774-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	df5957d5-20d3-483e-990b-d6369fb990b8	4fb568ce-a4be-46c5-862b-5c681936f30b	g.chr11:6477727C>A	uc001mdh.2	-	7	1616	c.1229G>T	c.(1228-1230)CGC>CTC	p.R410L	TRIM3_uc001mdi.2_Missense_Mutation_p.R410L|TRIM3_uc010raj.1_Missense_Mutation_p.R291L|TRIM3_uc009yfd.2_Missense_Mutation_p.R410L|TRIM3_uc010rak.1_Missense_Mutation_p.R410L|TRIM3_uc001mdj.2_Missense_Mutation_p.R291L	NM_006458	NP_006449	O75382	TRIM3_HUMAN	tripartite motif-containing 3	410	Filamin.				nervous system development|protein transport	early endosome	protein C-terminus binding|zinc ion binding			central_nervous_system(2)|large_intestine(1)|ovary(1)|skin(1)	5		all_lung(207;9.97e-06)|Lung NSC(207;1.74e-05)|Medulloblastoma(188;0.00225)|Breast(177;0.0204)|all_neural(188;0.0212)		Epithelial(150;9.34e-10)|Lung(200;0.0234)|LUSC - Lung squamous cell carcinoma(625;0.133)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GGGGCTGCCGCGCACTGGCTG	0.677	Melanoma(6;5 510 1540 25169 29084)		NA											14	5					4.93089e-13	7.0812e-13	0.020292	1	0
AMBRA1	55626	broad.mit.edu	37	11	46419198	46419198	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5774-01A-01D-1625-08	TCGA-64-5774-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	df5957d5-20d3-483e-990b-d6369fb990b8	4fb568ce-a4be-46c5-862b-5c681936f30b	g.chr11:46419198C>A	uc010rgu.1	-	18	4059	c.3699G>T	c.(3697-3699)TGG>TGT	p.W1233C	AMBRA1_uc010rgt.1_3'UTR|AMBRA1_uc009ylc.1_Missense_Mutation_p.W1204C|AMBRA1_uc001ncu.1_Missense_Mutation_p.W1143C|AMBRA1_uc001ncv.2_Missense_Mutation_p.W1236C|AMBRA1_uc001ncw.2_Missense_Mutation_p.W1114C|AMBRA1_uc001ncx.2_Missense_Mutation_p.W1173C	NM_017749	NP_060219	Q9C0C7	AMRA1_HUMAN	activating molecule in beclin-1-regulated	1233					autophagy|cell differentiation|nervous system development	autophagic vacuole|cytoplasmic vesicle				large_intestine(1)|ovary(1)|central_nervous_system(1)	3				GBM - Glioblastoma multiforme(35;0.0435)|Lung(87;0.182)		CAGGCTGGTCCCAGGAAGCTG	0.687			NA											17	5					3.32936e-07	4.26784e-07	0.006122	1	0
OR4X2	119764	broad.mit.edu	37	11	48267190	48267190	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5774-01A-01D-1625-08	TCGA-64-5774-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	df5957d5-20d3-483e-990b-d6369fb990b8	4fb568ce-a4be-46c5-862b-5c681936f30b	g.chr11:48267190C>A	uc001ngs.1	+	1	535	c.535C>A	c.(535-537)CTT>ATT	p.L179I		NM_001004727	NP_001004727	Q8NGF9	OR4X2_HUMAN	olfactory receptor, family 4, subfamily X,	179	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						CCTTCTCAAACTTGCCTGCTC	0.478			NA											87	72					2.5963e-48	5.33219e-48	0.01441	1	0
OR8J3	81168	broad.mit.edu	37	11	55904448	55904448	+	Silent	SNP	C	C	A			TCGA-64-5774-01A-01D-1625-08	TCGA-64-5774-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	df5957d5-20d3-483e-990b-d6369fb990b8	4fb568ce-a4be-46c5-862b-5c681936f30b	g.chr11:55904448C>A	uc010riz.1	-	1	747	c.747G>T	c.(745-747)ACG>ACT	p.T249T		NM_001004064	NP_001004064	Q8NGG0	OR8J3_HUMAN	olfactory receptor, family 8, subfamily J,	249	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2	Esophageal squamous(21;0.00693)					CATAGAAAACCGTGACTGCTA	0.398			NA											29	21					3.65163e-15	5.62469e-15	0.00632	1	0
C11orf9	745	broad.mit.edu	37	11	61533653	61533653	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5774-01A-01D-1625-08	TCGA-64-5774-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	df5957d5-20d3-483e-990b-d6369fb990b8	4fb568ce-a4be-46c5-862b-5c681936f30b	g.chr11:61533653C>A	uc001nsc.1	+	3	454	c.358C>A	c.(358-360)CCC>ACC	p.P120T	C11orf9_uc001nse.1_Missense_Mutation_p.P111T	NM_001127392	NP_001120864	Q9Y2G1	MRF_HUMAN	myelin gene regulatory factor isoform 2	120	Pro-rich.				central nervous system myelination|positive regulation of myelination|positive regulation of transcription, DNA-dependent	integral to membrane|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)	1						GGGCACCGGGCCCCCCATCAA	0.547			NA											10	20					1.3612e-06	1.69928e-06	0.003163	1	0
C11orf30	56946	broad.mit.edu	37	11	76162966	76162966	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5774-01A-01D-1625-08	TCGA-64-5774-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	df5957d5-20d3-483e-990b-d6369fb990b8	4fb568ce-a4be-46c5-862b-5c681936f30b	g.chr11:76162966G>T	uc001oxl.2	+	3	278	c.135G>T	c.(133-135)AAG>AAT	p.K45N	C11orf30_uc001oxj.2_Missense_Mutation_p.K45N|C11orf30_uc001oxk.2_Missense_Mutation_p.K45N|C11orf30_uc009yuj.1_Missense_Mutation_p.K45N|C11orf30_uc010rsa.1_Missense_Mutation_p.K45N|C11orf30_uc001oxm.2_Missense_Mutation_p.K45N|C11orf30_uc010rsb.1_Missense_Mutation_p.K45N|C11orf30_uc010rsc.1_Missense_Mutation_p.K45N|C11orf30_uc001oxn.2_Missense_Mutation_p.K45N|C11orf30_uc010rsd.1_Missense_Mutation_p.K45N	NM_020193	NP_064578	Q7Z589	EMSY_HUMAN	EMSY protein	45	Interaction with BRCA2.|ENT.				chromatin modification|DNA repair|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				ovary(5)|skin(1)	6						CCAAGGAAAAGAAAGATCTTC	0.348			NA											17	12					8.10497e-08	1.0531e-07	0.010504	1	0
LRRC32	2615	broad.mit.edu	37	11	76372262	76372262	+	Silent	SNP	G	G	A			TCGA-64-5774-01A-01D-1625-08	TCGA-64-5774-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	df5957d5-20d3-483e-990b-d6369fb990b8	4fb568ce-a4be-46c5-862b-5c681936f30b	g.chr11:76372262G>A	uc001oxq.3	-	3	618	c.375C>T	c.(373-375)CGC>CGT	p.R125R	LRRC32_uc001oxr.3_Silent_p.R125R|LRRC32_uc010rsf.1_Silent_p.R125R	NM_005512	NP_005503	Q14392	LRC32_HUMAN	leucine rich repeat containing 32 precursor	125	Extracellular (Potential).|LRR 4.					integral to plasma membrane					0						GGGAGGTCACGCGTGGCAGGG	0.692			NA											32	34					0	0	0.017118	0	0
DLG2	1740	broad.mit.edu	37	11	83170879	83170879	+	Silent	SNP	G	G	T			TCGA-64-5774-01A-01D-1625-08	TCGA-64-5774-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	df5957d5-20d3-483e-990b-d6369fb990b8	4fb568ce-a4be-46c5-862b-5c681936f30b	g.chr11:83170879G>T	uc001paj.2	-	23	2898	c.2595C>A	c.(2593-2595)CCC>CCA	p.P865P	DLG2_uc001pai.2_Silent_p.P744P|DLG2_uc010rsy.1_Silent_p.P814P|DLG2_uc010rsz.1_Silent_p.P861P|DLG2_uc010rta.1_Silent_p.P847P|DLG2_uc001pak.2_Silent_p.P970P|DLG2_uc010rsw.1_Silent_p.P329P|DLG2_uc010rsx.1_Silent_p.P342P	NM_001364	NP_001355	Q15700	DLG2_HUMAN	chapsyn-110 isoform 2	865						cell junction|postsynaptic density|postsynaptic membrane	guanylate kinase activity|protein binding|protein binding			ovary(3)|pancreas(2)|skin(1)	6		all_cancers(6;0.00791)|Acute lymphoblastic leukemia(157;4.44e-05)|all_hematologic(158;0.0036)				TTTCCTTTGAGGGAATCCAGA	0.353			NA											19	46					2.37509e-13	3.46292e-13	0.010504	1	0
DLG2	1740	broad.mit.edu	37	11	83177805	83177805	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5774-01A-01D-1625-08	TCGA-64-5774-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	df5957d5-20d3-483e-990b-d6369fb990b8	4fb568ce-a4be-46c5-862b-5c681936f30b	g.chr11:83177805G>T	uc001paj.2	-	21	2663	c.2360C>A	c.(2359-2361)GCC>GAC	p.A787D	DLG2_uc001pai.2_Missense_Mutation_p.A666D|DLG2_uc010rsy.1_Missense_Mutation_p.A736D|DLG2_uc010rsz.1_Missense_Mutation_p.A783D|DLG2_uc010rta.1_Missense_Mutation_p.A769D|DLG2_uc001pak.2_Missense_Mutation_p.A892D|DLG2_uc010rtb.1_Missense_Mutation_p.A754D|DLG2_uc010rsw.1_Missense_Mutation_p.A251D|DLG2_uc010rsx.1_Missense_Mutation_p.A264D	NM_001364	NP_001355	Q15700	DLG2_HUMAN	chapsyn-110 isoform 2	787	Guanylate kinase-like.					cell junction|postsynaptic density|postsynaptic membrane	guanylate kinase activity|protein binding|protein binding			ovary(3)|pancreas(2)|skin(1)	6		all_cancers(6;0.00791)|Acute lymphoblastic leukemia(157;4.44e-05)|all_hematologic(158;0.0036)				ATAGAGCTGGGCAACTTGTAA	0.433			NA											19	64					1.45105e-14	2.18229e-14	0.006122	1	0
TRIM49	57093	broad.mit.edu	37	11	89531774	89531774	+	Nonsense_Mutation	SNP	C	C	A			TCGA-64-5774-01A-01D-1625-08	TCGA-64-5774-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	df5957d5-20d3-483e-990b-d6369fb990b8	4fb568ce-a4be-46c5-862b-5c681936f30b	g.chr11:89531774C>A	uc001pdb.2	-	8	1212	c.883G>T	c.(883-885)GAA>TAA	p.E295*		NM_020358	NP_065091	P0CI25	TRI49_HUMAN	ring finger protein 18	295	B30.2/SPRY.					intracellular	zinc ion binding				0		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00556)				TTGTTGGCTTCTTCATGATGC	0.308			NA											8	19					1.06961e-07	1.38038e-07	0.00308	1	0
FAT3	120114	broad.mit.edu	37	11	92534753	92534753	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5774-01A-01D-1625-08	TCGA-64-5774-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	df5957d5-20d3-483e-990b-d6369fb990b8	4fb568ce-a4be-46c5-862b-5c681936f30b	g.chr11:92534753G>T	uc001pdj.3	+	9	8591	c.8574G>T	c.(8572-8574)CAG>CAT	p.Q2858H		NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	2858	Cadherin 26.|Extracellular (Potential).				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				CGGATTCCCAGCCCGAAAAGG	0.498			NA								TCGA Ovarian(4;0.039)			4	2					0.00909568	0.00954547	0.009096	1	0
MMP13	4322	broad.mit.edu	37	11	102816458	102816458	+	Missense_Mutation	SNP	A	A	G			TCGA-64-5774-01A-01D-1625-08	TCGA-64-5774-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	df5957d5-20d3-483e-990b-d6369fb990b8	4fb568ce-a4be-46c5-862b-5c681936f30b	g.chr11:102816458A>G	uc001phl.2	-	9	1260	c.1232T>C	c.(1231-1233)ATT>ACT	p.I411T		NM_002427	NP_002418	P45452	MMP13_HUMAN	matrix metalloproteinase 13 preproprotein	411	Hemopexin-like 3.				collagen catabolic process|proteolysis	extracellular space	metalloendopeptidase activity|zinc ion binding			ovary(2)|skin(1)	3		all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)		BRCA - Breast invasive adenocarcinoma(274;0.0144)		TTTATCCATAATATGGTTAGT	0.303			NA											18	42					0	0	0.010504	0	0
DDI1	414301	broad.mit.edu	37	11	103907704	103907704	+	Silent	SNP	C	C	A			TCGA-64-5774-01A-01D-1625-08	TCGA-64-5774-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	df5957d5-20d3-483e-990b-d6369fb990b8	4fb568ce-a4be-46c5-862b-5c681936f30b	g.chr11:103907704C>A	uc001phr.2	+	1	397	c.154C>A	c.(154-156)CGA>AGA	p.R52R	PDGFD_uc001php.2_Intron|PDGFD_uc001phq.2_Intron	NM_001001711	NP_001001711	Q8WTU0	DDI1_HUMAN	DDI1, DNA-damage inducible 1, homolog 1	52	Ubiquitin-like.				proteolysis		aspartic-type endopeptidase activity			large_intestine(3)|upper_aerodigestive_tract(1)|pancreas(1)	5		Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.00648)|Melanoma(852;0.055)|all_neural(303;0.164)		BRCA - Breast invasive adenocarcinoma(274;0.00128)|Epithelial(105;0.0631)|all cancers(92;0.169)		CCACATGGAGCGACTCCTCAT	0.572			NA											62	25					5.10508e-28	9.28639e-28	0.01441	1	0
ATM	472	broad.mit.edu	37	11	108153446	108153446	+	Nonsense_Mutation	SNP	A	A	T			TCGA-64-5774-01A-01D-1625-08	TCGA-64-5774-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	df5957d5-20d3-483e-990b-d6369fb990b8	4fb568ce-a4be-46c5-862b-5c681936f30b	g.chr11:108153446A>T	uc001pkb.1	+	25	3971	c.3586A>T	c.(3586-3588)AAA>TAA	p.K1196*	ATM_uc009yxr.1_Nonsense_Mutation_p.K1196*	NM_000051	NP_000042	Q13315	ATM_HUMAN	ataxia telangiectasia mutated isoform 1	1196					cell cycle arrest|cellular response to gamma radiation|DNA damage induced protein phosphorylation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|double-strand break repair via homologous recombination|G2/M transition DNA damage checkpoint|histone mRNA catabolic process|mitotic cell cycle spindle assembly checkpoint|negative regulation of B cell proliferation|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|pre-B cell allelic exclusion|protein autophosphorylation|reciprocal meiotic recombination|replicative senescence	cytoplasmic membrane-bounded vesicle|nucleoplasm	1-phosphatidylinositol-3-kinase activity|ATP binding|DNA binding|DNA-dependent protein kinase activity|identical protein binding|protein complex binding|protein dimerization activity|protein N-terminus binding			haematopoietic_and_lymphoid_tissue(174)|lung(25)|breast(15)|large_intestine(9)|ovary(5)|kidney(5)|central_nervous_system(4)|upper_aerodigestive_tract(1)|stomach(1)|NS(1)	240		all_cancers(61;9.64e-12)|all_epithelial(67;9.97e-08)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		Epithelial(105;9.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.06e-05)|all cancers(92;0.000208)|Colorectal(284;0.116)|OV - Ovarian serous cystadenocarcinoma(223;0.147)		GGTTTTAGAGAAAGTTTCTGA	0.289			NA	D|Mis|N|F|S		T-PLL	leukemia|lymphoma|medulloblastoma|glioma		Genes_defective_in_diseases_associated_with_sensitivity_to_DNA_damaging_agents	Ataxia_Telangiectasia	TSP Lung(14;0.12)			47	18					0	0	0.01441	0	0
TMEM225	338661	broad.mit.edu	37	11	123756006	123756006	+	Missense_Mutation	SNP	C	C	T			TCGA-64-5774-01A-01D-1625-08	TCGA-64-5774-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	df5957d5-20d3-483e-990b-d6369fb990b8	4fb568ce-a4be-46c5-862b-5c681936f30b	g.chr11:123756006C>T	uc001pzi.2	-	1	335	c.127G>A	c.(127-129)GCC>ACC	p.A43T		NM_001013743	NP_001013765	Q6GV28	TM225_HUMAN	transmembrane protein 225	43						integral to membrane				upper_aerodigestive_tract(1)|pancreas(1)|skin(1)	3						TTCATCTTGGCTCTTTCATCT	0.463			NA											25	46					0	0	0.008361	0	0
NANOG	79923	broad.mit.edu	37	12	7942298	7942298	+	Missense_Mutation	SNP	G	G	A			TCGA-64-5774-01A-01D-1625-08	TCGA-64-5774-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	df5957d5-20d3-483e-990b-d6369fb990b8	4fb568ce-a4be-46c5-862b-5c681936f30b	g.chr12:7942298G>A	uc009zfy.1	+	1	304	c.88G>A	c.(88-90)GGG>AGG	p.G30R		NM_024865	NP_079141	Q9H9S0	NANOG_HUMAN	Nanog homeobox	30					cell proliferation|embryo development|somatic stem cell maintenance	nucleolus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0				Kidney(36;0.0872)		TGTGATTTGTGGGCCTGAAGA	0.448			NA											43	78					0	0	0.013114	0	0
PZP	5858	broad.mit.edu	37	12	9305844	9305844	+	Silent	SNP	C	C	T			TCGA-64-5774-01A-01D-1625-08	TCGA-64-5774-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	df5957d5-20d3-483e-990b-d6369fb990b8	4fb568ce-a4be-46c5-862b-5c681936f30b	g.chr12:9305844C>T	uc001qvl.2	-	30	3899	c.3870G>A	c.(3868-3870)CAG>CAA	p.Q1290Q	PZP_uc009zgl.2_Silent_p.Q1076Q	NM_002864	NP_002855			pregnancy-zone protein precursor											ovary(3)|upper_aerodigestive_tract(1)|large_intestine(1)	5						TAGAAAAGGTCTGTGAATCCT	0.478	Melanoma(125;1402 1695 4685 34487 38571)		NA											30	85					0	0	0.009535	0	0
KRAS	3845	broad.mit.edu	37	12	25398285	25398285	+	Missense_Mutation	SNP	C	C	A	rs121913530		TCGA-64-5774-01A-01D-1625-08	TCGA-64-5774-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	df5957d5-20d3-483e-990b-d6369fb990b8	4fb568ce-a4be-46c5-862b-5c681936f30b	g.chr12:25398285C>A	uc001rgp.1	-	2	215	c.34G>T	c.(34-36)GGT>TGT	p.G12C	KRAS_uc001rgq.1_Missense_Mutation_p.G12C|KRAS_uc001rgr.2_RNA	NM_033360	NP_203524	P01116	RASK_HUMAN	c-K-ras2 protein isoform a precursor	12	GTP.		G -> D (in pancreatic carcinoma, GASC and lung carcinoma; somatic mutation).|G -> R (in lung cancer and bladder cancer; somatic mutation).|G -> S (in lung carcinoma and GASC; somatic mutation).|G -> A (in a colorectal cancer sample; somatic mutation).|G -> C (in lung carcinoma; somatic mutation).|G -> V (in lung carcinoma, pancreatic carcinoma, colon cancer and GASC; somatic mutation).		activation of MAPKK activity|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	plasma membrane	GTP binding|GTPase activity|protein binding	p.G12D(7175)|p.G12V(4780)|p.G12C(2482)|p.G12A(1180)|p.G12S(1119)|p.G12R(691)|p.G12?(50)|p.G12F(34)|p.G12G(6)|p.G12N(6)|p.G12L(5)|p.G12I(4)|p.G12_G13insG(4)|p.G12E(3)|p.G12W(3)|p.A11_G12insGA(2)|p.G12Y(2)|p.G12fs*3(1)		large_intestine(12391)|pancreas(3285)|lung(2847)|biliary_tract(521)|ovary(443)|endometrium(339)|haematopoietic_and_lymphoid_tissue(318)|stomach(203)|thyroid(149)|prostate(85)|soft_tissue(77)|small_intestine(62)|upper_aerodigestive_tract(59)|cervix(49)|urinary_tract(48)|skin(38)|liver(31)|breast(28)|testis(17)|oesophagus(15)|central_nervous_system(9)|peritoneum(6)|salivary_gland(6)|kidney(5)|gastrointestinal_tract_(site_indeterminate)(5)|thymus(5)|eye(4)|autonomic_ganglia(2)|bone(2)|genital_tract(1)|penis(1)|adrenal_gland(1)	21052	all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)		OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)			CCTACGCCACCAGCTCCAACT	0.348	Pancreas(8;6 143 191 305 2070 2426 4376 10944 11745 26467 38091 50869)	G12C(UMUC3_URINARY_TRACT)|G12R(CAL62_THYROID)|G12C(CALU1_LUNG)|G12C(NCIH2030_LUNG)|G12C(LU99_LUNG)|G12C(NCIH1792_LUNG)|G12R(KP2_PANCREAS)|G12C(KHM1B_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12C(NCIH2122_LUNG)|G12C(NCIH358_LUNG)|G12R(PSN1_PANCREAS)|G12C(KYSE410_OESOPHAGUS)|G12S(A549_LUNG)|G12R(HUPT3_PANCREAS)|G12R(TCCPAN2_PANCREAS)|G12C(HCC44_LUNG)|G12S(KMS20_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12C(SW1463_LARGE_INTESTINE)|G12C(NCIH23_LUNG)|G12C(LU65_LUNG)|G12C(NCIH1373_LUNG)|G12C(MIAPACA2_PANCREAS)|G12R(HS274T_BREAST)|G12S(LS123_LARGE_INTESTINE)|G12C(SW1573_LUNG)|G12C(SW837_LARGE_INTESTINE)|G12C(OV56_OVARY)|G12C(IALM_LUNG)	119	Mis		pancreatic|colorectal|lung|thyroid|AML|others				Cardiofaciocutaneous_syndrome|Noonan_syndrome	TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)			15	10					1.49906e-05	1.76741e-05	0.020292	1	0
MLL2	8085	broad.mit.edu	37	12	49419995	49419995	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5774-01A-01D-1625-08	TCGA-64-5774-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	df5957d5-20d3-483e-990b-d6369fb990b8	4fb568ce-a4be-46c5-862b-5c681936f30b	g.chr12:49419995C>A	uc001rta.3	-	48	15754	c.15754G>T	c.(15754-15756)GAC>TAC	p.D5252Y		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	5252	FYR C-terminal.				chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						AAGACCAGGTCCTCCAGGCCC	0.537			NA	N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			10	58					2.17888e-05	2.55316e-05	0.006214	1	0
DPY19L2	283417	broad.mit.edu	37	12	64061909	64061909	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5774-01A-01D-1625-08	TCGA-64-5774-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	df5957d5-20d3-483e-990b-d6369fb990b8	4fb568ce-a4be-46c5-862b-5c681936f30b	g.chr12:64061909G>T	uc001srp.1	-	1	446	c.265C>A	c.(265-267)CTG>ATG	p.L89M	DPY19L2_uc009zqk.1_RNA	NM_173812	NP_776173	Q6NUT2	D19L2_HUMAN	dpy-19-like 2	89					multicellular organismal development|spermatid development	integral to membrane				central_nervous_system(1)|skin(1)	2			GBM - Glioblastoma multiforme(1;2.77e-05)	GBM - Glioblastoma multiforme(28;0.044)		AGCTGCGCCAGGGAATTACGG	0.607			NA											74	52					1.45978e-39	2.87441e-39	0.01441	1	0
NTN4	59277	broad.mit.edu	37	12	96107067	96107067	+	Missense_Mutation	SNP	T	T	C			TCGA-64-5774-01A-01D-1625-08	TCGA-64-5774-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	df5957d5-20d3-483e-990b-d6369fb990b8	4fb568ce-a4be-46c5-862b-5c681936f30b	g.chr12:96107067T>C	uc001tei.2	-	4	1363	c.914A>G	c.(913-915)CAG>CGG	p.Q305R	NTN4_uc009ztf.2_Missense_Mutation_p.Q305R|NTN4_uc009ztg.2_Missense_Mutation_p.Q268R	NM_021229	NP_067052	Q9HB63	NET4_HUMAN	netrin 4 precursor	305	Laminin EGF-like 1.				axon guidance	basement membrane|plasma membrane				upper_aerodigestive_tract(1)|ovary(1)	2						GGCACAGTGCTGGCAGTGGCT	0.522			NA											11	38					0	0	0.010729	0	0
RASAL1	8437	broad.mit.edu	37	12	113554954	113554954	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5774-01A-01D-1625-08	TCGA-64-5774-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	df5957d5-20d3-483e-990b-d6369fb990b8	4fb568ce-a4be-46c5-862b-5c681936f30b	g.chr12:113554954G>T	uc001tum.1	-	9	948	c.655C>A	c.(655-657)CCA>ACA	p.P219T	RASAL1_uc010syp.1_Missense_Mutation_p.P219T|RASAL1_uc001tul.2_Missense_Mutation_p.P219T|RASAL1_uc001tun.1_Missense_Mutation_p.P219T|RASAL1_uc010syq.1_Missense_Mutation_p.P219T|RASAL1_uc001tuo.3_Missense_Mutation_p.P219T|RASAL1_uc010syr.1_Missense_Mutation_p.P219T	NM_004658	NP_004649	O95294	RASL1_HUMAN	RAS protein activator like 1	219					intracellular signal transduction|negative regulation of Ras protein signal transduction	cytoplasm|intrinsic to internal side of plasma membrane	metal ion binding|phospholipid binding|Ras GTPase activator activity			ovary(2)|skin(2)	4						AGGGTCTTTGGAGAGAACTCC	0.612			NA											25	16					1.2476e-16	1.95321e-16	0.00632	1	0
NUFIP1	26747	broad.mit.edu	37	13	45523952	45523952	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5774-01A-01D-1625-08	TCGA-64-5774-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	df5957d5-20d3-483e-990b-d6369fb990b8	4fb568ce-a4be-46c5-862b-5c681936f30b	g.chr13:45523952G>T	uc001uzp.2	-	8	1085	c.1043C>A	c.(1042-1044)CCA>CAA	p.P348Q		NM_012345	NP_036477	Q9UHK0	NUFP1_HUMAN	nuclear fragile X mental retardation protein	348					box C/D snoRNP assembly|positive regulation of transcription from RNA polymerase II promoter|RNA processing	actin cytoskeleton|cytosolic ribosome|nuclear matrix|nucleolus|perichromatin fibrils|pre-snoRNP complex|presynaptic active zone|transcription elongation factor complex	DNA binding|identical protein binding|protein binding, bridging|RNA binding|zinc ion binding				0		Lung NSC(96;8.23e-05)|Breast(139;0.00378)|Prostate(109;0.0107)|all_hematologic(4;0.014)|Lung SC(185;0.0262)|Hepatocellular(98;0.0524)|Acute lymphoblastic leukemia(4;0.143)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;0.000306)|BRCA - Breast invasive adenocarcinoma(63;0.125)		AGAATGTTGTGGTTTCTCCTC	0.448			NA											3	33					0.004672	0.00498521	0.004672	1	0
FAM70B	348013	broad.mit.edu	37	13	114507949	114507949	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5774-01A-01D-1625-08	TCGA-64-5774-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	df5957d5-20d3-483e-990b-d6369fb990b8	4fb568ce-a4be-46c5-862b-5c681936f30b	g.chr13:114507949G>T	uc001vuh.2	+	8	788	c.761G>T	c.(760-762)CGC>CTC	p.R254L		NM_182614	NP_872420	Q8WV15	FA70B_HUMAN	family with sequence similarity 70, member B	254						integral to membrane					0	Lung NSC(43;0.00976)|all_neural(89;0.0337)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_lung(25;0.123)|all_epithelial(44;0.133)	all cancers(43;0.181)			GCAGGCTTCCGCCTGACGCCC	0.677			NA											36	7					6.2361e-21	1.01803e-20	0.007835	1	0
MYH7	4625	broad.mit.edu	37	14	23894904	23894904	+	Missense_Mutation	SNP	C	C	G			TCGA-64-5774-01A-01D-1625-08	TCGA-64-5774-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	df5957d5-20d3-483e-990b-d6369fb990b8	4fb568ce-a4be-46c5-862b-5c681936f30b	g.chr14:23894904C>G	uc001wjx.2	-	20	2392	c.2286G>C	c.(2284-2286)AAG>AAC	p.K762N		NM_000257	NP_000248	P12883	MYH7_HUMAN	myosin, heavy chain 7, cardiac muscle, beta	762	Actin-binding.|Myosin head-like.				adult heart development|muscle filament sliding|regulation of heart rate|ventricular cardiac muscle tissue morphogenesis	focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(3)|skin(1)	4	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00725)		CTTTCCTCACCTTGGTGTGGC	0.448			NA											34	60					0	0	0.017118	0	0
SEC23A	10484	broad.mit.edu	37	14	39560913	39560913	+	Missense_Mutation	SNP	C	C	A	rs148560912		TCGA-64-5774-01A-01D-1625-08	TCGA-64-5774-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	df5957d5-20d3-483e-990b-d6369fb990b8	4fb568ce-a4be-46c5-862b-5c681936f30b	g.chr14:39560913C>A	uc001wup.1	-	5	594	c.371G>T	c.(370-372)GGT>GTT	p.G124V	SEC23A_uc010tqa.1_5'UTR|SEC23A_uc010tqb.1_Missense_Mutation_p.G95V|SEC23A_uc010tqc.1_5'UTR	NM_006364	NP_006355	Q15436	SC23A_HUMAN	SEC23-related protein A	124					COPII vesicle coating|intracellular protein transport|post-translational protein modification|protein N-linked glycosylation via asparagine	COPII vesicle coat|cytosol|Golgi membrane|smooth endoplasmic reticulum membrane	protein binding|zinc ion binding			ovary(4)|upper_aerodigestive_tract(1)	5	Hepatocellular(127;0.213)		Lung(238;0.00047)|LUAD - Lung adenocarcinoma(48;0.000565)	GBM - Glioblastoma multiforme(112;0.0151)		CATCTGAGGACCACGCTTTTA	0.343			NA											35	34					9.45814e-24	1.64228e-23	0.021022	1	0
SDCCAG1	9147	broad.mit.edu	37	14	50272777	50272777	+	Silent	SNP	G	G	T			TCGA-64-5774-01A-01D-1625-08	TCGA-64-5774-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	df5957d5-20d3-483e-990b-d6369fb990b8	4fb568ce-a4be-46c5-862b-5c681936f30b	g.chr14:50272777G>T	uc001wxc.2	-	19	1887	c.1819C>A	c.(1819-1821)CGA>AGA	p.R607R	SDCCAG1_uc010anj.1_Silent_p.R607R|SDCCAG1_uc010tqi.1_Silent_p.R586R|SDCCAG1_uc001wxe.2_Silent_p.R565R|SDCCAG1_uc001wxd.1_Silent_p.R12R	NM_004713	NP_004704	O60524	NEMF_HUMAN	serologically defined colon cancer antigen 1	607						cytoplasm|nucleus					0	all_epithelial(31;0.000822)|Breast(41;0.0117)	all_lung(585;1.02e-05)		OV - Ovarian serous cystadenocarcinoma(311;5.99e-34)		GTGATAACTCGTGCATCCCAA	0.388			NA											24	20					9.90768e-06	1.19017e-05	0.004656	1	0
ACOT2	10965	broad.mit.edu	37	14	74036534	74036534	+	Missense_Mutation	SNP	G	G	C			TCGA-64-5774-01A-01D-1625-08	TCGA-64-5774-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	df5957d5-20d3-483e-990b-d6369fb990b8	4fb568ce-a4be-46c5-862b-5c681936f30b	g.chr14:74036534G>C	uc001xon.3	+	1	763	c.590G>C	c.(589-591)CGG>CCG	p.R197P	ACOT1_uc010tuc.1_Intron|ACOT2_uc001xom.2_Intron	NM_006821	NP_006812	P49753	ACOT2_HUMAN	acyl-CoA thioesterase 2	197					acyl-CoA metabolic process|long-chain fatty acid metabolic process|very long-chain fatty acid metabolic process	mitochondrion	carboxylesterase activity|palmitoyl-CoA hydrolase activity|protein binding			skin(1)	1				BRCA - Breast invasive adenocarcinoma(234;0.0033)|OV - Ovarian serous cystadenocarcinoma(108;0.0639)		CCCGGGGTGCGGCGCGAGCCG	0.697			NA											13	7					0	0	0.016723	0	0
OR4M2	390538	broad.mit.edu	37	15	22369186	22369186	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5774-01A-01D-1625-08	TCGA-64-5774-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	df5957d5-20d3-483e-990b-d6369fb990b8	4fb568ce-a4be-46c5-862b-5c681936f30b	g.chr15:22369186G>T	uc010tzu.1	+	1	611	c.611G>T	c.(610-612)GGT>GTT	p.G204V	LOC727924_uc001yua.2_Intron|LOC727924_uc001yub.1_Intron|OR4N4_uc001yuc.1_Intron	NM_001004719	NP_001004719	Q8NGB6	OR4M2_HUMAN	olfactory receptor, family 4, subfamily M,	204	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		all_cancers(20;1.94e-20)|all_epithelial(15;3.94e-18)|Lung NSC(15;8.53e-15)|all_lung(15;2.87e-14)|Breast(32;0.00519)|Colorectal(260;0.101)	GBM - Glioblastoma multiforme(6;0.124)	all cancers(64;1.64e-11)|Epithelial(43;5.81e-10)|BRCA - Breast invasive adenocarcinoma(123;0.000255)|Kidney(6;0.00736)|KIRC - Kidney renal clear cell carcinoma(6;0.0135)|GBM - Glioblastoma multiforme(186;0.0963)		TGTAGTAGTGGTCTGATCTCT	0.468			NA											77	30					2.02726e-29	3.79615e-29	0.01441	1	0
TMOD3	29766	broad.mit.edu	37	15	52188673	52188673	+	Missense_Mutation	SNP	G	G	A			TCGA-64-5774-01A-01D-1625-08	TCGA-64-5774-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	df5957d5-20d3-483e-990b-d6369fb990b8	4fb568ce-a4be-46c5-862b-5c681936f30b	g.chr15:52188673G>A	uc002abm.2	+	7	904	c.685G>A	c.(685-687)GTG>ATG	p.V229M	TMOD3_uc010bfc.1_RNA	NM_014547	NP_055362	Q9NYL9	TMOD3_HUMAN	tropomodulin 3 (ubiquitous)	229						cytoplasm|cytoskeleton	actin binding|tropomyosin binding			ovary(1)	1				all cancers(107;0.00194)		CAACACACATGTGAAATGTTT	0.383	Colon(122;1837 2251 18387 22826)		NA											24	34					0	0	0.021523	0	0
PCSK6	5046	broad.mit.edu	37	15	101865129	101865129	+	Missense_Mutation	SNP	C	C	T			TCGA-64-5774-01A-01D-1625-08	TCGA-64-5774-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	df5957d5-20d3-483e-990b-d6369fb990b8	4fb568ce-a4be-46c5-862b-5c681936f30b	g.chr15:101865129C>T	uc002bwy.2	-	18	2617	c.2303G>A	c.(2302-2304)CGC>CAC	p.R768H	PCSK6_uc010bpd.2_Missense_Mutation_p.R564H|PCSK6_uc010bpe.2_Missense_Mutation_p.R755H|PCSK6_uc002bxa.2_Missense_Mutation_p.R768H|PCSK6_uc002bxb.2_Missense_Mutation_p.R755H	NM_002570	NP_002561	P29122	PCSK6_HUMAN	paired basic amino acid cleaving system 4	768	CRM (Cys-rich motif).				glycoprotein metabolic process|nerve growth factor processing|nerve growth factor production|nerve growth factor receptor signaling pathway|regulation of BMP signaling pathway|secretion by cell	cell surface|endomembrane system|endoplasmic reticulum|extracellular matrix|extracellular space|Golgi lumen|membrane|soluble fraction	eukaryotic cell surface binding|heparin binding|nerve growth factor binding|serine-type endopeptidase activity			pancreas(2)	2	Lung NSC(78;0.00102)|all_lung(78;0.00128)|Melanoma(26;0.00505)		OV - Ovarian serous cystadenocarcinoma(32;0.000803)|LUSC - Lung squamous cell carcinoma(107;0.187)|Lung(145;0.23)			GAACCCGCGGCGGCAAGACAG	0.567			NA											7	30					0	0	0.00308	0	0
ABCA3	21	broad.mit.edu	37	16	2338079	2338079	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5774-01A-01D-1625-08	TCGA-64-5774-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	df5957d5-20d3-483e-990b-d6369fb990b8	4fb568ce-a4be-46c5-862b-5c681936f30b	g.chr16:2338079C>A	uc002cpy.1	-	21	3664	c.2952G>T	c.(2950-2952)GAG>GAT	p.E984D	ABCA3_uc010bsk.1_Missense_Mutation_p.E926D	NM_001089	NP_001080	Q99758	ABCA3_HUMAN	ATP-binding cassette, sub-family A member 3	984					response to drug	integral to membrane|lamellar body|membrane fraction|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(5)|ovary(5)|central_nervous_system(3)|upper_aerodigestive_tract(1)|lung(1)|skin(1)	16		Ovarian(90;0.17)				CTTTCAGATGCTCTGACAGCT	0.677			NA											5	7					1.23904e-05	1.46992e-05	0.014758	1	0
OR2C1	4993	broad.mit.edu	37	16	3406340	3406340	+	Missense_Mutation	SNP	G	G	A	rs147461021	byFrequency	TCGA-64-5774-01A-01D-1625-08	TCGA-64-5774-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	df5957d5-20d3-483e-990b-d6369fb990b8	4fb568ce-a4be-46c5-862b-5c681936f30b	g.chr16:3406340G>A	uc002cuw.1	+	1	452	c.400G>A	c.(400-402)GCC>ACC	p.A134T		NM_012368	NP_036500	O95371	OR2C1_HUMAN	olfactory receptor, family 2, subfamily C,	134	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						CCGCTACACCGCCATCATGAA	0.612			NA											14	27					0	0	0.007413	0	0
C16orf71	146562	broad.mit.edu	37	16	4790576	4790576	+	Silent	SNP	G	G	A			TCGA-64-5774-01A-01D-1625-08	TCGA-64-5774-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	df5957d5-20d3-483e-990b-d6369fb990b8	4fb568ce-a4be-46c5-862b-5c681936f30b	g.chr16:4790576G>A	uc002cxn.2	+	4	1161	c.699G>A	c.(697-699)GCG>GCA	p.A233A		NM_139170	NP_631909	Q8IYS4	CP071_HUMAN	hypothetical protein LOC146562	233										central_nervous_system(1)	1						TGAAGGAGGCGCCCTGCCACG	0.637			NA											10	16					0	0	0.010729	0	0
ABCC11	85320	broad.mit.edu	37	16	48256677	48256677	+	Silent	SNP	C	C	A			TCGA-64-5774-01A-01D-1625-08	TCGA-64-5774-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	df5957d5-20d3-483e-990b-d6369fb990b8	4fb568ce-a4be-46c5-862b-5c681936f30b	g.chr16:48256677C>A	uc002eff.1	-	5	959	c.609G>T	c.(607-609)GTG>GTT	p.V203V	ABCC11_uc002efg.1_Silent_p.V203V|ABCC11_uc002efh.1_Silent_p.V203V|ABCC11_uc010vgl.1_Silent_p.V203V	NM_033151	NP_149163	Q96J66	ABCCB_HUMAN	ATP-binding cassette, sub-family C, member 11	203	ABC transmembrane type-1 1.|Helical; (Potential).					integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(3)|skin(2)|central_nervous_system(1)	6		all_cancers(37;0.127)|all_lung(18;0.132)|Breast(268;0.166)				AGCAGAGTCCCACTCCATGGA	0.458			NA							Cerumen_Type				9	23					3.86212e-05	4.44376e-05	0.008291	1	0
PLEKHG4	25894	broad.mit.edu	37	16	67322099	67322099	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5774-01A-01D-1625-08	TCGA-64-5774-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	df5957d5-20d3-483e-990b-d6369fb990b8	4fb568ce-a4be-46c5-862b-5c681936f30b	g.chr16:67322099G>T	uc002eso.3	+	19	5785	c.3250G>T	c.(3250-3252)GCC>TCC	p.A1084S	PLEKHG4_uc002esp.3_Missense_Mutation_p.A891S|PLEKHG4_uc002esq.3_Missense_Mutation_p.A1084S|PLEKHG4_uc010cef.2_Missense_Mutation_p.A1084S|PLEKHG4_uc002ess.3_Missense_Mutation_p.A1084S|PLEKHG4_uc010ceg.2_Missense_Mutation_p.A1003S	NM_015432	NP_056247	Q58EX7	PKHG4_HUMAN	pleckstrin homology domain containing, family G	1084					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			skin(1)|pancreas(1)	2				OV - Ovarian serous cystadenocarcinoma(108;0.00376)|Epithelial(162;0.0173)|all cancers(182;0.116)|Kidney(780;0.119)		CATTGCCGTAGCCCCGTTTGA	0.607			NA											18	61					1.01871e-10	1.37024e-10	0.008871	1	0
IRF8	3394	broad.mit.edu	37	16	85946755	85946755	+	Missense_Mutation	SNP	A	A	G			TCGA-64-5774-01A-01D-1625-08	TCGA-64-5774-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	df5957d5-20d3-483e-990b-d6369fb990b8	4fb568ce-a4be-46c5-862b-5c681936f30b	g.chr16:85946755A>G	uc002fjh.2	+	5	523	c.466A>G	c.(466-468)ATG>GTG	p.M156V	IRF8_uc010chp.2_Intron	NM_002163	NP_002154	Q02556	IRF8_HUMAN	interferon regulatory factor 8	156					interferon-gamma-mediated signaling pathway|negative regulation of transcription from RNA polymerase II promoter|type I interferon-mediated signaling pathway	nucleus	DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity			breast(2)|ovary(1)	3		Prostate(104;0.0771)				GGACGATTACATGGGGATGAT	0.602			NA											32	60					0	0	0.021022	0	0
SPNS3	201305	broad.mit.edu	37	17	4337281	4337281	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5774-01A-01D-1625-08	TCGA-64-5774-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	df5957d5-20d3-483e-990b-d6369fb990b8	4fb568ce-a4be-46c5-862b-5c681936f30b	g.chr17:4337281G>T	uc002fxt.2	+	1	63	c.19G>T	c.(19-21)GCG>TCG	p.A7S	SPNS3_uc002fxu.2_5'UTR	NM_182538	NP_872344	Q6ZMD2	SPNS3_HUMAN	spinster homolog 3	7					lipid transport|transmembrane transport	integral to membrane				large_intestine(1)	1						GGGGATGTCAGCGGAGTGCCC	0.667			NA											6	8					8.12818e-05	9.13225e-05	0.001984	1	0
PIK3R5	23533	broad.mit.edu	37	17	8791618	8791618	+	Missense_Mutation	SNP	C	C	T			TCGA-64-5774-01A-01D-1625-08	TCGA-64-5774-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	df5957d5-20d3-483e-990b-d6369fb990b8	4fb568ce-a4be-46c5-862b-5c681936f30b	g.chr17:8791618C>T	uc002glt.2	-	10	1553	c.1486G>A	c.(1486-1488)GCT>ACT	p.A496T	PIK3R5_uc010vuz.1_Missense_Mutation_p.A496T|PIK3R5_uc002glu.3_Missense_Mutation_p.A110T|PIK3R5_uc010coa.1_3'UTR|PIK3R5_uc010cob.1_Missense_Mutation_p.A110T	NM_014308	NP_055123	Q8WYR1	PI3R5_HUMAN	phosphoinositide-3-kinase, regulatory subunit 5	496					platelet activation	cytosol|membrane|nucleus				breast(2)|large_intestine(1)|central_nervous_system(1)|skin(1)	5						GGGCGTGAAGCAGGGGCCAGA	0.662	NSCLC(18;589 615 7696 20311 50332)		NA											16	28					0	0	0.004007	0	0
MYH13	8735	broad.mit.edu	37	17	10212976	10212976	+	Missense_Mutation	SNP	G	G	A			TCGA-64-5774-01A-01D-1625-08	TCGA-64-5774-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	df5957d5-20d3-483e-990b-d6369fb990b8	4fb568ce-a4be-46c5-862b-5c681936f30b	g.chr17:10212976G>A	uc002gmk.1	-	34	4918	c.4828C>T	c.(4828-4830)CGC>TGC	p.R1610C		NM_003802	NP_003793	Q9UKX3	MYH13_HUMAN	myosin, heavy polypeptide 13, skeletal muscle	1610	Potential.				muscle contraction	muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(4)|skin(2)	6						TTCCGGCTGCGGATTTCAGCA	0.552			NA											6	11					0	0	0.001168	0	0
MYH2	4620	broad.mit.edu	37	17	10426814	10426814	+	Missense_Mutation	SNP	C	C	T			TCGA-64-5774-01A-01D-1625-08	TCGA-64-5774-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	df5957d5-20d3-483e-990b-d6369fb990b8	4fb568ce-a4be-46c5-862b-5c681936f30b	g.chr17:10426814C>T	uc010coi.2	-	37	5599	c.5471G>A	c.(5470-5472)AGG>AAG	p.R1824K	uc002gml.1_Intron|MYH2_uc002gmp.3_Missense_Mutation_p.R1824K|MYH2_uc010coj.2_Intron	NM_001100112	NP_001093582	Q9UKX2	MYH2_HUMAN	myosin heavy chain IIa	1824	Potential.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(5)|pancreas(4)|skin(3)|lung(1)|kidney(1)	14						GAGACCCACCCTGGCCTCCAG	0.517			NA											22	42					0	0	0.014323	0	0
GAS2L2	246176	broad.mit.edu	37	17	34072791	34072791	+	Silent	SNP	G	G	T			TCGA-64-5774-01A-01D-1625-08	TCGA-64-5774-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	df5957d5-20d3-483e-990b-d6369fb990b8	4fb568ce-a4be-46c5-862b-5c681936f30b	g.chr17:34072791G>T	uc002hjv.1	-	6	1753	c.1725C>A	c.(1723-1725)TCC>TCA	p.S575S		NM_139285	NP_644814	Q8NHY3	GA2L2_HUMAN	growth arrest-specific 2 like 2	575					cell cycle arrest	cytoplasm|cytoskeleton				ovary(1)|skin(1)	2		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		CCAGGTCCCAGGACTCTCTGG	0.612			NA											22	79					5.45024e-15	8.32797e-15	0.01892	1	0
MLLT6	4302	broad.mit.edu	37	17	36873066	36873066	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5774-01A-01D-1625-08	TCGA-64-5774-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	df5957d5-20d3-483e-990b-d6369fb990b8	4fb568ce-a4be-46c5-862b-5c681936f30b	g.chr17:36873066G>T	uc002hqi.3	+	10	1496	c.1483G>T	c.(1483-1485)GCC>TCC	p.A495S	MLLT6_uc002hqj.2_Intron|MLLT6_uc002hqk.3_5'Flank	NM_005937	NP_005928	P55198	AF17_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	495					regulation of transcription, DNA-dependent	nucleus	protein binding|zinc ion binding			breast(3)|prostate(1)|lung(1)|skin(1)	6	Breast(7;4.43e-21)					GGGCCCAGCTGCCCCATCCTT	0.662			NA	T	MLL	AL								5	25					3.59834e-05	4.16535e-05	0.001168	1	0
KRT12	3859	broad.mit.edu	37	17	39021155	39021155	+	Missense_Mutation	SNP	C	C	T			TCGA-64-5774-01A-01D-1625-08	TCGA-64-5774-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	df5957d5-20d3-483e-990b-d6369fb990b8	4fb568ce-a4be-46c5-862b-5c681936f30b	g.chr17:39021155C>T	uc002hvk.2	-	3	734	c.710G>A	c.(709-711)CGG>CAG	p.R237Q		NM_000223	NP_000214	Q99456	K1C12_HUMAN	keratin 12	237	Rod.|Coil 1B.				visual perception	intermediate filament	structural molecule activity			ovary(1)	1		Breast(137;0.000301)				GTCCAGCACCCGGCGCAGGCC	0.572			NA											36	114					0	0	0.021022	0	0
BECN1	8678	broad.mit.edu	37	17	40962818	40962818	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5774-01A-01D-1625-08	TCGA-64-5774-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	df5957d5-20d3-483e-990b-d6369fb990b8	4fb568ce-a4be-46c5-862b-5c681936f30b	g.chr17:40962818C>A	uc002ibo.3	-	12	1448	c.1313G>T	c.(1312-1314)TGG>TTG	p.W438L	CNTD1_uc002ibm.3_3'UTR|CNTD1_uc010wha.1_3'UTR|BECN1_uc010whb.1_Missense_Mutation_p.W351L|BECN1_uc010whc.1_3'UTR|BECN1_uc002ibn.2_Missense_Mutation_p.W438L	NM_003766	NP_003757	Q14457	BECN1_HUMAN	beclin 1	438					anti-apoptosis|cell cycle|cellular defense response|cytokinesis|response to virus	membrane	protein binding			ovary(1)	1		Breast(137;0.00104)		BRCA - Breast invasive adenocarcinoma(366;0.0745)		AGCAAGACCCCACTTAAGATT	0.428			NA											22	80					1.64293e-13	2.41385e-13	0.01892	1	0
WNT9B	7484	broad.mit.edu	37	17	44950100	44950100	+	Missense_Mutation	SNP	A	A	T			TCGA-64-5774-01A-01D-1625-08	TCGA-64-5774-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	df5957d5-20d3-483e-990b-d6369fb990b8	4fb568ce-a4be-46c5-862b-5c681936f30b	g.chr17:44950100A>T	uc002ikw.1	+	2	332	c.295A>T	c.(295-297)AAC>TAC	p.N99Y	WNT9B_uc002ikx.1_Missense_Mutation_p.N99Y	NM_003396	NP_003387	O14905	WNT9B_HUMAN	wingless-type MMTV integration site family,	99					anterior/posterior pattern formation|axis specification|branching involved in ureteric bud morphogenesis|canonical Wnt receptor signaling pathway|cell-cell signaling|cellular response to retinoic acid|collecting duct development|cornea development in camera-type eye|endoderm development|establishment of planar polarity involved in nephron morphogenesis|kidney rudiment formation|male genitalia development|mesonephric duct formation|metanephric tubule development|neuron differentiation|palate development|regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis|uterus morphogenesis|Wnt receptor signaling pathway, calcium modulating pathway|Wnt receptor signaling pathway, planar cell polarity pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	extracellular matrix structural constituent|G-protein-coupled receptor binding			lung(2)	2			BRCA - Breast invasive adenocarcinoma(9;0.0257)			TGAGCGCTGGAACTGTAGCCT	0.672			NA											4	24					0	0	0.014758	0	0
ABI3	51225	broad.mit.edu	37	17	47299555	47299555	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5774-01A-01D-1625-08	TCGA-64-5774-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	df5957d5-20d3-483e-990b-d6369fb990b8	4fb568ce-a4be-46c5-862b-5c681936f30b	g.chr17:47299555C>A	uc002iop.1	+	7	1403	c.905C>A	c.(904-906)CCC>CAC	p.P302H	ABI3_uc002ioq.1_Missense_Mutation_p.P296H	NM_016428	NP_057512	Q9P2A4	ABI3_HUMAN	NESH protein isoform 1	302	Pro-rich.				cellular component movement|regulation of cell migration	cytoplasm|lamellipodium	protein binding				0			Epithelial(5;6.37e-06)|all cancers(6;6.36e-05)			CCTGATGAGCCCAGCTGGGTG	0.612			NA								HNSCC(55;0.14)			70	33					1.74474e-33	3.40047e-33	0.01441	1	0
DNAH17	8632	broad.mit.edu	37	17	76503840	76503840	+	Silent	SNP	G	G	A			TCGA-64-5774-01A-01D-1625-08	TCGA-64-5774-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	df5957d5-20d3-483e-990b-d6369fb990b8	4fb568ce-a4be-46c5-862b-5c681936f30b	g.chr17:76503840G>A	uc010wtu.1	-	2	336	c.159C>T	c.(157-159)CAC>CAT	p.H53H						full-length cDNA clone CS0DJ002YI14 of T cells (Jurkat cell line) Cot 10-normalized of Homo sapiens (human).											ovary(6)|breast(2)|skin(1)	9			BRCA - Breast invasive adenocarcinoma(99;0.00294)|OV - Ovarian serous cystadenocarcinoma(97;0.0656)			GGTGCGGCTCGTGCTGGAATT	0.552			NA											4	10					0	0	0.014758	0	0
ZNF521	25925	broad.mit.edu	37	18	22804516	22804516	+	Silent	SNP	C	C	T			TCGA-64-5774-01A-01D-1625-08	TCGA-64-5774-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	df5957d5-20d3-483e-990b-d6369fb990b8	4fb568ce-a4be-46c5-862b-5c681936f30b	g.chr18:22804516C>T	uc002kvk.2	-	4	3613	c.3366G>A	c.(3364-3366)GAG>GAA	p.E1122E	ZNF521_uc010xbe.1_RNA|ZNF521_uc010dly.2_Silent_p.E1122E|ZNF521_uc002kvl.2_Silent_p.E902E	NM_015461	NP_056276	Q96K83	ZN521_HUMAN	zinc finger protein 521	1122					cell differentiation|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein domain specific binding|zinc ion binding			ovary(4)|large_intestine(2)|lung(1)	7	all_cancers(21;0.0025)|all_epithelial(16;3.62e-05)|Ovarian(20;0.0991)					CACTCAGATTCTCATTCTGGC	0.547			NA	T	PAX5	ALL								22	16					0	0	0.016522	0	0
ZNF532	55205	broad.mit.edu	37	18	56651409	56651409	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5774-01A-01D-1625-08	TCGA-64-5774-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	df5957d5-20d3-483e-990b-d6369fb990b8	4fb568ce-a4be-46c5-862b-5c681936f30b	g.chr18:56651409G>T	uc002lho.2	+	11	4164	c.3617G>T	c.(3616-3618)CGG>CTG	p.R1206L	ZNF532_uc002lhp.2_Missense_Mutation_p.R1204L|ZNF532_uc010xeg.1_Missense_Mutation_p.R1204L|ZNF532_uc002lhr.2_Missense_Mutation_p.R1204L|ZNF532_uc002lhs.2_Missense_Mutation_p.R1204L|ZNF532_uc010xeh.1_Missense_Mutation_p.R294L	NM_018181	NP_060651	Q9HCE3	ZN532_HUMAN	zinc finger protein 532	1206	C2H2-type 11.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|skin(1)	2						TACCAGTGCCGGGAGTGTGGC	0.532			NA											3	35					0.004672	0.00498521	0.004672	1	0
SPPL2B	56928	broad.mit.edu	37	19	2337525	2337525	+	Silent	SNP	C	C	A			TCGA-64-5774-01A-01D-1625-08	TCGA-64-5774-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	df5957d5-20d3-483e-990b-d6369fb990b8	4fb568ce-a4be-46c5-862b-5c681936f30b	g.chr19:2337525C>A	uc002lvs.2	+	3	350	c.270C>A	c.(268-270)ATC>ATA	p.I90I	SPPL2B_uc010dsw.1_Silent_p.I62I|SPPL2B_uc010dsy.1_Silent_p.I62I|SPPL2B_uc010dsz.1_Silent_p.I90I|SPPL2B_uc002lvr.2_Silent_p.I90I|SPPL2B_uc010dta.1_5'Flank|SPPL2B_uc002lvu.2_5'Flank	NM_152988	NP_694533	Q8TCT7	PSL1_HUMAN	signal peptide peptidase-like 2B isoform 2	90	Cytoplasmic (Potential).|PA.					Golgi membrane|integral to membrane	aspartic-type endopeptidase activity				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GCAACCAGATCCCGCTGGTGG	0.672			NA											38	9					9.85913e-13	1.40529e-12	0.009718	1	0
ACER1	125981	broad.mit.edu	37	19	6306758	6306758	+	Nonsense_Mutation	SNP	G	G	T			TCGA-64-5774-01A-01D-1625-08	TCGA-64-5774-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	df5957d5-20d3-483e-990b-d6369fb990b8	4fb568ce-a4be-46c5-862b-5c681936f30b	g.chr19:6306758G>T	uc002mel.2	-	6	840	c.762C>A	c.(760-762)TAC>TAA	p.Y254*		NM_133492	NP_597999	Q8TDN7	ACER1_HUMAN	alkaline ceramidase 1	254	Cytoplasmic (Potential).					endoplasmic reticulum membrane|integral to membrane	ceramidase activity				0						GGATTTCCACGTAGGGCAGCC	0.577			NA											13	3					2.23348e-06	2.73459e-06	0.004007	1	0
CCNE1	898	broad.mit.edu	37	19	30314605	30314606	+	Missense_Mutation	DNP	GG	GG	CT			TCGA-64-5774-01A-01D-1625-08	TCGA-64-5774-10A-01D-1625-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	df5957d5-20d3-483e-990b-d6369fb990b8	4fb568ce-a4be-46c5-862b-5c681936f30b	g.chr19:30314605_30314606GG>CT	uc002nsn.2	+	12	1337_1338	c.1154_1155GG>CT	c.(1153-1155)AGG>ACT	p.R385T	CCNE1_uc002nso.2_Missense_Mutation_p.R370T|CCNE1_uc002nsp.2_Missense_Mutation_p.R132T	NM_001238	NP_001229	P24864	CCNE1_HUMAN	cyclin E1 isoform 1	385					androgen receptor signaling pathway|cell division|positive regulation of transcription, DNA-dependent|regulation of cyclin-dependent protein kinase activity|regulation of transcription involved in G1/S phase of mitotic cell cycle	cytosol|nucleoplasm	androgen receptor binding|protein kinase binding|transcription coactivator activity			lung(2)	2	all_cancers(1;2.19e-31)|all_epithelial(1;1.49e-30)|all_lung(1;1.37e-11)|Lung NSC(1;2.35e-11)|Ovarian(5;0.000902)|Breast(6;0.0203)|Esophageal squamous(110;0.195)		UCEC - Uterine corpus endometrioid carcinoma (4;2.65e-06)|Epithelial(1;6.85e-98)|all cancers(1;1.38e-94)|OV - Ovarian serous cystadenocarcinoma(1;1.38e-90)|STAD - Stomach adenocarcinoma(5;5.8e-07)|GBM - Glioblastoma multiforme(4;0.0394)|Lung(7;0.092)|LUAD - Lung adenocarcinoma(5;0.115)|BRCA - Breast invasive adenocarcinoma(6;0.183)|COAD - Colon adenocarcinoma(1;0.188)|Colorectal(1;0.202)			GAACAAAATAGGGCTTCTCCTC	0.525			NA											17	39					0	0	0.004672	0	0
TSHZ3	57616	broad.mit.edu	37	19	31770491	31770491	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5774-01A-01D-1625-08	TCGA-64-5774-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	df5957d5-20d3-483e-990b-d6369fb990b8	4fb568ce-a4be-46c5-862b-5c681936f30b	g.chr19:31770491G>T	uc002nsy.3	-	2	273	c.208C>A	c.(208-210)CAT>AAT	p.H70N		NM_020856	NP_065907	Q63HK5	TSH3_HUMAN	zinc finger protein 537	70					negative regulation of transcription, DNA-dependent|regulation of respiratory gaseous exchange by neurological system process	growth cone|nucleus	chromatin binding|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)|skin(2)|pancreas(1)|lung(1)	8	Esophageal squamous(110;0.226)					TCCATTTCATGGCAGGAAAAC	0.592			NA											8	17					0.000157383	0.000174769	0.00308	1	0
KIR3DL1	3811	broad.mit.edu	37	19	55331209	55331209	+	Silent	SNP	C	C	T			TCGA-64-5774-01A-01D-1625-08	TCGA-64-5774-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	df5957d5-20d3-483e-990b-d6369fb990b8	4fb568ce-a4be-46c5-862b-5c681936f30b	g.chr19:55331209C>T	uc002qhk.3	+	4	460	c.397C>T	c.(397-399)CTG>TTG	p.L133L	KIR2DS4_uc010yfj.1_Intron|KIR2DS4_uc010yfk.1_Intron|KIR3DL1_uc010yfn.1_Silent_p.L75L|KIR3DL1_uc010esf.2_Silent_p.L38L|KIR3DL1_uc010yfo.1_Silent_p.L75L|KIR3DL1_uc002qhl.3_Silent_p.L133L	NM_013289	NP_037421	P43629	KI3L1_HUMAN	killer cell immunoglobulin-like receptor, three	133	Extracellular (Potential).				immune response|regulation of immune response	integral to plasma membrane	HLA-B specific inhibitory MHC class I receptor activity	p.L133Q(1)		ovary(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|skin(1)	5				GBM - Glioblastoma multiforme(193;0.0192)		CCCAGGTCCCCTGGTGAAATC	0.488			NA											40	29					0	0	0.01441	0	0
NLRP8	126205	broad.mit.edu	37	19	56466759	56466759	+	Silent	SNP	G	G	A			TCGA-64-5774-01A-01D-1625-08	TCGA-64-5774-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	df5957d5-20d3-483e-990b-d6369fb990b8	4fb568ce-a4be-46c5-862b-5c681936f30b	g.chr19:56466759G>A	uc002qmh.2	+	3	1406	c.1335G>A	c.(1333-1335)AAG>AAA	p.K445K	NLRP8_uc010etg.2_Silent_p.K445K	NM_176811	NP_789781	Q86W28	NALP8_HUMAN	NLR family, pyrin domain containing 8	445	NACHT.					cytoplasm	ATP binding			ovary(4)|breast(3)|central_nervous_system(2)|skin(2)|large_intestine(1)|kidney(1)	13		Colorectal(82;0.000147)|Ovarian(87;0.17)		GBM - Glioblastoma multiforme(193;0.0695)		TTTCCAGAAAGATCCACCAAG	0.483			NA											25	33					0	0	0.004656	0	0
PDIA6	10130	broad.mit.edu	37	2	10927471	10927471	+	Missense_Mutation	SNP	G	G	A	rs138012463		TCGA-64-5774-01A-01D-1625-08	TCGA-64-5774-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	df5957d5-20d3-483e-990b-d6369fb990b8	4fb568ce-a4be-46c5-862b-5c681936f30b	g.chr2:10927471G>A	uc002rau.2	-	11	1231	c.1093C>T	c.(1093-1095)CGC>TGC	p.R365C	PDIA6_uc010yjg.1_Missense_Mutation_p.R362C|PDIA6_uc002rav.2_Missense_Mutation_p.R417C|PDIA6_uc010yjh.1_Missense_Mutation_p.R370C|PDIA6_uc002raw.2_Missense_Mutation_p.R413C	NM_005742	NP_005733	Q15084	PDIA6_HUMAN	protein disulfide isomerase A6 precursor	365					cell redox homeostasis|glycerol ether metabolic process|protein folding	endoplasmic reticulum lumen|ER-Golgi intermediate compartment|melanosome|plasma membrane	electron carrier activity|protein binding|protein disulfide isomerase activity|protein disulfide oxidoreductase activity				0	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.191)			Epithelial(75;0.149)|OV - Ovarian serous cystadenocarcinoma(76;0.15)		TTCATCTTGCGTGCATTGATG	0.493	GBM(73;509 1219 34219 41343 41551)		NA											39	64					0	0	0.00623	0	0
DDX1	1653	broad.mit.edu	37	2	15742716	15742716	+	Nonsense_Mutation	SNP	G	G	T			TCGA-64-5774-01A-01D-1625-08	TCGA-64-5774-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	df5957d5-20d3-483e-990b-d6369fb990b8	4fb568ce-a4be-46c5-862b-5c681936f30b	g.chr2:15742716G>T	uc002rce.2	+	7	640	c.352G>T	c.(352-354)GAA>TAA	p.E118*	DDX1_uc010yjq.1_Nonsense_Mutation_p.E26*	NM_004939	NP_004930	Q92499	DDX1_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 1	118	B30.2/SPRY.|Necessary for interaction with HNRNPK.|Necessary for interaction with RELA.|Helicase ATP-binding.				DNA duplex unwinding|double-strand break repair|multicellular organismal development|regulation of transcription, DNA-dependent|regulation of translational initiation|spliceosome assembly|transcription, DNA-dependent	cleavage body|stress granule|tRNA-splicing ligase complex	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding|DNA/RNA helicase activity|exonuclease activity|poly(A) RNA binding|protein binding|RNA helicase activity|transcription cofactor activity	p.E118K(1)		central_nervous_system(2)|upper_aerodigestive_tract(1)|ovary(1)	4	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.197)	all_epithelial(98;2.96e-07)|Acute lymphoblastic leukemia(84;4.24e-05)|Ovarian(717;0.0694)	GBM - Glioblastoma multiforme(3;0.00969)	Epithelial(75;4.35e-05)|OV - Ovarian serous cystadenocarcinoma(76;0.133)		AGAAGTAAAGGAATGGCATGG	0.373			NA											21	41					6.36457e-07	8.05055e-07	0.021523	1	0
DNMT3A	1788	broad.mit.edu	37	2	25468194	25468195	+	Missense_Mutation	DNP	GC	GC	AG			TCGA-64-5774-01A-01D-1625-08	TCGA-64-5774-10A-01D-1625-08	GC	GC	-	-	GC	GC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	df5957d5-20d3-483e-990b-d6369fb990b8	4fb568ce-a4be-46c5-862b-5c681936f30b	g.chr2:25468194_25468195GC>AG	uc002rgc.2	-	13	1738_1739	c.1481_1482GC>CT	c.(1480-1482)TGC>TCT	p.C494S	DNMT3A_uc002rgd.2_Missense_Mutation_p.C494S|DNMT3A_uc010eyi.2_RNA|DNMT3A_uc002rgb.2_Missense_Mutation_p.C305S	NM_022552	NP_072046	Q9Y6K1	DNM3A_HUMAN	DNA cytosine methyltransferase 3 alpha isoform	494	Interaction with the PRC2/EED-EZH2 complex (By similarity).|GATA-type; atypical.|ADD.				regulation of gene expression by genetic imprinting	cytoplasm|euchromatin|nuclear matrix	DNA (cytosine-5-)-methyltransferase activity|DNA binding|metal ion binding|protein binding			haematopoietic_and_lymphoid_tissue(133)|lung(4)|ovary(3)	140	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CACAGGAGATGCAGATGTCTGG	0.604			NA	Mis|F|N|S		AML								8	17					0	0	0.004672	0	0
NRXN1	9378	broad.mit.edu	37	2	50779824	50779824	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5774-01A-01D-1625-08	TCGA-64-5774-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	df5957d5-20d3-483e-990b-d6369fb990b8	4fb568ce-a4be-46c5-862b-5c681936f30b	g.chr2:50779824G>T	uc010fbq.2	-	9	3257	c.1780C>A	c.(1780-1782)CTG>ATG	p.L594M	NRXN1_uc002rxb.3_Missense_Mutation_p.L226M|NRXN1_uc002rxe.3_Missense_Mutation_p.L554M|NRXN1_uc002rxc.1_RNA	NM_001135659	NP_001129131	P58400	NRX1B_HUMAN	neurexin 1 isoform alpha2 precursor	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					angiogenesis|neuron cell-cell adhesion|neuronal signal transduction	cell surface|endocytic vesicle|integral to membrane|presynaptic membrane	cell adhesion molecule binding|receptor binding			ovary(2)	2		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.192)	Lung(47;0.0813)|LUSC - Lung squamous cell carcinoma(58;0.116)			CCCATGTCCAGGAGGAGGTAG	0.473			NA											58	83					9.59835e-30	1.81513e-29	0.01441	1	0
LRRTM4	80059	broad.mit.edu	37	2	77745683	77745683	+	Missense_Mutation	SNP	T	T	C			TCGA-64-5774-01A-01D-1625-08	TCGA-64-5774-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	df5957d5-20d3-483e-990b-d6369fb990b8	4fb568ce-a4be-46c5-862b-5c681936f30b	g.chr2:77745683T>C	uc002snr.2	-	3	1727	c.1312A>G	c.(1312-1314)ATG>GTG	p.M438V	LRRTM4_uc002snq.2_Missense_Mutation_p.M438V|LRRTM4_uc002sns.2_Missense_Mutation_p.M438V|LRRTM4_uc002snt.2_Missense_Mutation_p.M439V	NM_001134745	NP_001128217	Q86VH4	LRRT4_HUMAN	leucine rich repeat transmembrane neuronal 4	438	Helical; (Potential).					integral to membrane				pancreas(3)|ovary(1)	4				Colorectal(11;0.059)		AAGAGGATCATGGCCACTGAG	0.493			NA											39	33					0	0	0.00874	0	0
YSK4	80122	broad.mit.edu	37	2	135756462	135756462	+	Silent	SNP	G	G	T			TCGA-64-5774-01A-01D-1625-08	TCGA-64-5774-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	df5957d5-20d3-483e-990b-d6369fb990b8	4fb568ce-a4be-46c5-862b-5c681936f30b	g.chr2:135756462G>T	uc002tue.1	-	5	451	c.420C>A	c.(418-420)CCC>CCA	p.P140P	YSK4_uc010fne.1_Silent_p.P112P|YSK4_uc002tuf.1_Silent_p.P140P|YSK4_uc010fnc.1_Silent_p.P140P|YSK4_uc010fnd.1_Intron|YSK4_uc010zbg.1_Silent_p.P140P|YSK4_uc002tui.3_Silent_p.P157P	NM_025052	NP_079328	Q56UN5	YSK4_HUMAN	Yeast Sps1/Ste20-related kinase 4 isoform 1	140							ATP binding|protein serine/threonine kinase activity			stomach(2)|urinary_tract(1)|ovary(1)|breast(1)	5				BRCA - Breast invasive adenocarcinoma(221;0.112)		GCAAAACTAAGGGCCGCATGG	0.433			NA											11	43					3.07112e-06	3.71255e-06	0.010729	1	0
GALNT5	11227	broad.mit.edu	37	2	158142621	158142621	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5774-01A-01D-1625-08	TCGA-64-5774-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	df5957d5-20d3-483e-990b-d6369fb990b8	4fb568ce-a4be-46c5-862b-5c681936f30b	g.chr2:158142621G>T	uc002tzg.2	+	3	1971	c.1716G>T	c.(1714-1716)AGG>AGT	p.R572S	GALNT5_uc010zci.1_RNA	NM_014568	NP_055383	Q7Z7M9	GALT5_HUMAN	N-acetylgalactosaminyltransferase 5	572	Catalytic subdomain A.|Lumenal (Potential).				glycosaminoglycan biosynthetic process	Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			breast(3)|skin(1)	4						TAAGGGCCAGGCTGGCAGGAG	0.303			NA											9	40					5.16669e-11	6.99884e-11	0.010729	1	0
CHRNA1	1134	broad.mit.edu	37	2	175622341	175622341	+	Missense_Mutation	SNP	G	G	C			TCGA-64-5774-01A-01D-1625-08	TCGA-64-5774-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	df5957d5-20d3-483e-990b-d6369fb990b8	4fb568ce-a4be-46c5-862b-5c681936f30b	g.chr2:175622341G>C	uc002ujd.2	-	5	450	c.372C>G	c.(370-372)CAC>CAG	p.H124Q	uc002uiw.2_Intron|CHRNA1_uc002uje.2_Missense_Mutation_p.H99Q|CHRNA1_uc002ujf.3_Missense_Mutation_p.H99Q	NM_001039523	NP_001034612	P02708	ACHA_HUMAN	nicotinic cholinergic receptor alpha 1 isoform a	124	Extracellular.				muscle cell homeostasis|neuromuscular junction development|neuromuscular process|neuromuscular synaptic transmission|neuron homeostasis|regulation of action potential in neuron|skeletal muscle contraction|skeletal muscle tissue growth	cell junction|cell surface|neuromuscular junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity			ovary(2)|central_nervous_system(1)|skin(1)	4						CTGAAGGAATGTGAATTTTTT	0.438			NA											38	36					0	0	0.005524	0	0
COL5A2	1290	broad.mit.edu	37	2	189927933	189927933	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5774-01A-01D-1625-08	TCGA-64-5774-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	df5957d5-20d3-483e-990b-d6369fb990b8	4fb568ce-a4be-46c5-862b-5c681936f30b	g.chr2:189927933C>A	uc002uqk.2	-	27	2109	c.1834G>T	c.(1834-1836)GGG>TGG	p.G612W	COL5A2_uc010frx.2_Missense_Mutation_p.G188W	NM_000393	NP_000384	P05997	CO5A2_HUMAN	alpha 2 type V collagen preproprotein	612					axon guidance|collagen fibril organization|eye morphogenesis|skin development	collagen type V	extracellular matrix structural constituent			ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.127)			CCCATGCTCCCGGGCTGCCCT	0.517			NA											58	69					2.01871e-26	3.63749e-26	0.01441	1	0
ANKAR	150709	broad.mit.edu	37	2	190554683	190554683	+	Silent	SNP	T	T	C			TCGA-64-5774-01A-01D-1625-08	TCGA-64-5774-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	df5957d5-20d3-483e-990b-d6369fb990b8	4fb568ce-a4be-46c5-862b-5c681936f30b	g.chr2:190554683T>C	uc002uqw.1	+	2	819	c.819T>C	c.(817-819)CCT>CCC	p.P273P	ANKAR_uc002uqu.2_RNA|ANKAR_uc002uqv.1_Silent_p.P344P	NM_144708	NP_653309	Q7Z5J8	ANKAR_HUMAN	ankyrin and armadillo repeat containing	344						integral to membrane	binding			ovary(2)|pancreas(1)|skin(1)	4			OV - Ovarian serous cystadenocarcinoma(117;0.00156)|Epithelial(96;0.0256)|all cancers(119;0.0744)			TGCTTCAGCCTTTTTCAGGTA	0.289			NA											3	65					0	0	0.009096	0	0
CAPN10	11132	broad.mit.edu	37	2	241536200	241536200	+	Silent	SNP	G	G	T			TCGA-64-5774-01A-01D-1625-08	TCGA-64-5774-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	df5957d5-20d3-483e-990b-d6369fb990b8	4fb568ce-a4be-46c5-862b-5c681936f30b	g.chr2:241536200G>T	uc002vzk.1	+	9	1768	c.1584G>T	c.(1582-1584)ACG>ACT	p.T528T	CAPN10_uc002vzl.1_Intron|CAPN10_uc002vzm.1_Intron|CAPN10_uc002vzn.1_Silent_p.T400T|CAPN10_uc002vzo.1_Intron|CAPN10_uc010fzg.1_Intron|CAPN10_uc002vzp.1_Intron|CAPN10_uc002vzq.1_Intron	NM_023083	NP_075571	Q9HC96	CAN10_HUMAN	calpain 10 isoform a	528	Domain III 2.				actin cytoskeleton reorganization|cellular response to insulin stimulus|positive regulation of apoptosis|positive regulation of glucose import|positive regulation of insulin secretion|positive regulation of intracellular transport|proteolysis	cytosol|plasma membrane	calcium-dependent cysteine-type endopeptidase activity|cytoskeletal protein binding|SNARE binding			ovary(3)|large_intestine(2)|lung(1)	6		all_epithelial(40;1.72e-15)|Breast(86;2.14e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0294)|all_neural(83;0.0459)|Lung NSC(271;0.094)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;1.13e-31)|all cancers(36;3.24e-29)|OV - Ovarian serous cystadenocarcinoma(60;2.82e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;5.1e-06)|Lung(119;0.00168)|Colorectal(34;0.00495)|LUSC - Lung squamous cell carcinoma(224;0.00813)|COAD - Colon adenocarcinoma(134;0.032)		TCGGCCAGACGGCGGGGGGCA	0.701			NA											27	26					2.24059e-21	3.75398e-21	0.00632	1	0
SIRPB1	10326	broad.mit.edu	37	20	1559087	1559087	+	Silent	SNP	G	G	T			TCGA-64-5774-01A-01D-1625-08	TCGA-64-5774-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	df5957d5-20d3-483e-990b-d6369fb990b8	4fb568ce-a4be-46c5-862b-5c681936f30b	g.chr20:1559087G>T	uc010gai.2	-	2	429	c.330C>A	c.(328-330)ATC>ATA	p.I110I	SIRPB1_uc002wfk.3_Silent_p.I110I	NM_006065	NP_006056	O00241	SIRB1_HUMAN	signal-regulatory protein beta 1 isoform 1	110	Extracellular (Potential).|Ig-like V-type.				cell junction assembly|cell surface receptor linked signaling pathway	integral to plasma membrane	protein binding			ovary(1)	1						CTGCTGGGGTGATGTTACTGA	0.502			NA											39	83					2.58029e-29	4.7848e-29	0.009718	1	0
MYLK2	85366	broad.mit.edu	37	20	30408221	30408221	+	Silent	SNP	G	G	A			TCGA-64-5774-01A-01D-1625-08	TCGA-64-5774-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	df5957d5-20d3-483e-990b-d6369fb990b8	4fb568ce-a4be-46c5-862b-5c681936f30b	g.chr20:30408221G>A	uc002wwq.2	+	3	447	c.345G>A	c.(343-345)CAG>CAA	p.Q115Q		NM_033118	NP_149109	Q9H1R3	MYLK2_HUMAN	skeletal myosin light chain kinase	115					cardiac muscle tissue morphogenesis|regulation of muscle filament sliding		ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity|myosin light chain kinase activity			lung(2)|skin(2)|ovary(1)|central_nervous_system(1)	6			Colorectal(19;0.00306)|COAD - Colon adenocarcinoma(19;0.0347)			AGGCTGAGCAGGGAGCCTCAG	0.692			NA											23	33					0	0	0.004656	0	0
MYBL2	4605	broad.mit.edu	37	20	42331478	42331478	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5774-01A-01D-1625-08	TCGA-64-5774-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	df5957d5-20d3-483e-990b-d6369fb990b8	4fb568ce-a4be-46c5-862b-5c681936f30b	g.chr20:42331478G>T	uc002xlb.1	+	8	1515	c.1300G>T	c.(1300-1302)GAT>TAT	p.D434Y	MYBL2_uc010zwj.1_Missense_Mutation_p.D410Y|MYBL2_uc002xla.1_Missense_Mutation_p.D434Y	NM_002466	NP_002457	P10244	MYBB_HUMAN	MYB-related protein B	434						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			lung(3)|kidney(2)	5		Myeloproliferative disorder(115;0.00452)	COAD - Colon adenocarcinoma(18;0.0031)			GTCCTTCCTGGATTCCTGTAA	0.602			NA											23	46					4.16121e-05	4.75923e-05	0.016522	1	0
SLC12A5	57468	broad.mit.edu	37	20	44685923	44685923	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5774-01A-01D-1625-08	TCGA-64-5774-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	df5957d5-20d3-483e-990b-d6369fb990b8	4fb568ce-a4be-46c5-862b-5c681936f30b	g.chr20:44685923C>A	uc010zxl.1	+	25	3385	c.3309C>A	c.(3307-3309)AAC>AAA	p.N1103K	SLC12A5_uc002xrb.2_Missense_Mutation_p.N1080K	NM_001134771	NP_001128243	Q9H2X9	S12A5_HUMAN	solute carrier family 12 (potassium-chloride	1103	Cytoplasmic (Potential).				potassium ion transport|sodium ion transport	integral to membrane	potassium:chloride symporter activity			ovary(2)|large_intestine(1)|central_nervous_system(1)|skin(1)	5		Myeloproliferative disorder(115;0.0122)			Bumetanide(DB00887)|Potassium Chloride(DB00761)	CTCCCCGCAACCGCAATGGTG	0.567			NA											15	116					7.07596e-05	7.99709e-05	0.006122	1	0
SLC2A10	81031	broad.mit.edu	37	20	45355567	45355567	+	Missense_Mutation	SNP	C	C	G			TCGA-64-5774-01A-01D-1625-08	TCGA-64-5774-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	df5957d5-20d3-483e-990b-d6369fb990b8	4fb568ce-a4be-46c5-862b-5c681936f30b	g.chr20:45355567C>G	uc002xsl.2	+	3	1450	c.1353C>G	c.(1351-1353)TGC>TGG	p.C451W		NM_030777	NP_110404	O95528	GTR10_HUMAN	solute carrier family 2 member 10	451	Helical; Name=11; (Potential).					endomembrane system|integral to membrane|perinuclear region of cytoplasm|plasma membrane	D-glucose transmembrane transporter activity|sugar:hydrogen symporter activity			ovary(1)	1		Myeloproliferative disorder(115;0.0122)				TCGCCTTCTGCAACAGCTTCA	0.502			NA											6	153					0	0	0.001168	0	0
ATP9A	10079	broad.mit.edu	37	20	50244178	50244178	+	Silent	SNP	T	T	C			TCGA-64-5774-01A-01D-1625-08	TCGA-64-5774-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	df5957d5-20d3-483e-990b-d6369fb990b8	4fb568ce-a4be-46c5-862b-5c681936f30b	g.chr20:50244178T>C	uc002xwg.1	-	17	1806	c.1806A>G	c.(1804-1806)GCA>GCG	p.A602A	ATP9A_uc010gih.1_Silent_p.A466A|ATP9A_uc002xwf.1_Intron	NM_006045	NP_006036	O75110	ATP9A_HUMAN	ATPase, class II, type 9A	602	Cytoplasmic (Potential).				ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(4)	4						GAGACTTCTTTGCCACCACGA	0.403			NA											67	256					0	0	0.01441	0	0
LAMA5	3911	broad.mit.edu	37	20	60913645	60913645	+	Silent	SNP	T	T	A			TCGA-64-5774-01A-01D-1625-08	TCGA-64-5774-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	df5957d5-20d3-483e-990b-d6369fb990b8	4fb568ce-a4be-46c5-862b-5c681936f30b	g.chr20:60913645T>A	uc002ycq.2	-	12	1564	c.1497A>T	c.(1495-1497)GCA>GCT	p.A499A		NM_005560	NP_005551	O15230	LAMA5_HUMAN	laminin alpha 5 precursor	499	Laminin EGF-like 4.				angiogenesis|cell proliferation|cell recognition|cytoskeleton organization|endothelial cell differentiation|focal adhesion assembly|integrin-mediated signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-11 complex	integrin binding			ovary(1)|pancreas(1)|skin(1)	3	Breast(26;1.57e-08)		BRCA - Breast invasive adenocarcinoma(19;4.36e-06)		Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	CCTGGGTCCCTGCCGCGCTGC	0.647			NA											10	6					0	0	0.010729	0	0
ADAMTS5	11096	broad.mit.edu	37	21	28315732	28315732	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5774-01A-01D-1625-08	TCGA-64-5774-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	df5957d5-20d3-483e-990b-d6369fb990b8	4fb568ce-a4be-46c5-862b-5c681936f30b	g.chr21:28315732C>A	uc002ymg.2	-	3	2101	c.1372G>T	c.(1372-1374)GCC>TCC	p.A458S		NM_007038	NP_008969	Q9UNA0	ATS5_HUMAN	ADAM metallopeptidase with thrombospondin type 1	458	Peptidase M12B.				proteolysis	proteinaceous extracellular matrix	integrin binding|metalloendopeptidase activity|zinc ion binding			upper_aerodigestive_tract(2)|ovary(1)|pancreas(1)	4						GTGATGGTGGCTGAAGTGCAT	0.423	Esophageal Squamous(53;683 1080 10100 14424 45938)		NA											11	20					3.07112e-06	3.71255e-06	0.010729	1	0
RIPK4	54101	broad.mit.edu	37	21	43187057	43187057	+	Missense_Mutation	SNP	C	C	T			TCGA-64-5774-01A-01D-1625-08	TCGA-64-5774-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	df5957d5-20d3-483e-990b-d6369fb990b8	4fb568ce-a4be-46c5-862b-5c681936f30b	g.chr21:43187057C>T	uc002yzn.1	-	1	193	c.145G>A	c.(145-147)GCC>ACC	p.A49T		NM_020639	NP_065690	P57078	RIPK4_HUMAN	ankyrin repeat domain 3	49						cytoplasm|nucleus	ATP binding|protein serine/threonine kinase activity			ovary(2)|central_nervous_system(2)|large_intestine(1)|lung(1)|skin(1)	7						CACTTGATGGCCAGCCAGGTC	0.488			NA											9	7					0	0	0.006214	0	0
MYO18B	84700	broad.mit.edu	37	22	26165124	26165124	+	Missense_Mutation	SNP	A	A	T			TCGA-64-5774-01A-01D-1625-08	TCGA-64-5774-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	df5957d5-20d3-483e-990b-d6369fb990b8	4fb568ce-a4be-46c5-862b-5c681936f30b	g.chr22:26165124A>T	uc003abz.1	+	4	1491	c.1241A>T	c.(1240-1242)AAG>ATG	p.K414M	MYO18B_uc003aca.1_Missense_Mutation_p.K295M|MYO18B_uc010guy.1_Missense_Mutation_p.K295M|MYO18B_uc010guz.1_Missense_Mutation_p.K295M|MYO18B_uc011aka.1_Translation_Start_Site|MYO18B_uc011akb.1_5'Flank	NM_032608	NP_115997	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	414						nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity			ovary(5)|central_nervous_system(3)|large_intestine(2)|breast(2)	12						CAGACAGAGAAGGGCTGTGAA	0.607			NA											4	4					0	0	0.001168	0	0
SH3BP1	23616	broad.mit.edu	37	22	38046636	38046636	+	Missense_Mutation	SNP	C	C	T			TCGA-64-5774-01A-01D-1625-08	TCGA-64-5774-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	df5957d5-20d3-483e-990b-d6369fb990b8	4fb568ce-a4be-46c5-862b-5c681936f30b	g.chr22:38046636C>T	uc003ati.2	+	16	1613	c.1502C>T	c.(1501-1503)TCC>TTC	p.S501F	SH3BP1_uc003atg.1_RNA|SH3BP1_uc011anl.1_3'UTR|SH3BP1_uc003ath.1_Missense_Mutation_p.S501F|SH3BP1_uc003atj.1_Missense_Mutation_p.S437F|SH3BP1_uc003atk.1_Missense_Mutation_p.S415F|uc003atl.1_RNA	NM_018957	NP_061830	Q9Y3L3	3BP1_HUMAN	SH3-domain binding protein 1	501					signal transduction	cytoplasm	GTPase activator activity|SH3 domain binding			central_nervous_system(1)	1	Melanoma(58;0.0574)					GAACTTCCGTCCACTGCCGTG	0.398			NA											15	32					0	0	0.004007	0	0
IL17RE	132014	broad.mit.edu	37	3	9948463	9948463	+	Missense_Mutation	SNP	A	A	T			TCGA-64-5774-01A-01D-1625-08	TCGA-64-5774-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	df5957d5-20d3-483e-990b-d6369fb990b8	4fb568ce-a4be-46c5-862b-5c681936f30b	g.chr3:9948463A>T	uc003btu.2	+	6	557	c.440A>T	c.(439-441)CAC>CTC	p.H147L	CIDEC_uc003bto.2_Intron|IL17RE_uc003btv.2_Missense_Mutation_p.H147L|IL17RE_uc011atn.1_RNA|IL17RE_uc003btw.2_Missense_Mutation_p.H147L|IL17RE_uc003btx.2_Missense_Mutation_p.H31L|IL17RE_uc010hcq.2_Missense_Mutation_p.H147L|IL17RE_uc003bty.2_RNA	NM_153483	NP_705616	Q8NFR9	I17RE_HUMAN	interleukin 17 receptor E isoform 1	147	Extracellular (Potential).					cytoplasm|extracellular region|integral to membrane	receptor activity			central_nervous_system(1)	1				OV - Ovarian serous cystadenocarcinoma(96;5.34e-64)		GACATCTCCCACAAGGGACTT	0.542			NA											6	88					0	0	0.001168	0	0
HTR1F	3355	broad.mit.edu	37	3	88040430	88040430	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5774-01A-01D-1625-08	TCGA-64-5774-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	df5957d5-20d3-483e-990b-d6369fb990b8	4fb568ce-a4be-46c5-862b-5c681936f30b	g.chr3:88040430C>A	uc003dqr.2	+	2	689	c.531C>A	c.(529-531)GAC>GAA	p.D177E		NM_000866	NP_000857	P30939	5HT1F_HUMAN	5-hydroxytryptamine (serotonin) receptor 1F	177	Extracellular (By similarity).				G-protein signaling, coupled to cyclic nucleotide second messenger|synaptic transmission	integral to plasma membrane	serotonin binding|serotonin receptor activity			ovary(3)	3	all_cancers(8;0.147)	Lung NSC(201;0.0283)		LUSC - Lung squamous cell carcinoma(29;0.00353)|Lung(72;0.00664)	Eletriptan(DB00216)|Naratriptan(DB00952)|Rizatriptan(DB00953)|Sumatriptan(DB00669)|Zolmitriptan(DB00315)	TCAAGCACGACCACATTGTTT	0.378			NA											27	8					7.76418e-22	1.31235e-21	0.005443	1	0
ZPLD1	131368	broad.mit.edu	37	3	102189285	102189285	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5774-01A-01D-1625-08	TCGA-64-5774-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	df5957d5-20d3-483e-990b-d6369fb990b8	4fb568ce-a4be-46c5-862b-5c681936f30b	g.chr3:102189285G>T	uc003dvs.1	+	16	1863	c.981G>T	c.(979-981)TGG>TGT	p.W327C	ZPLD1_uc003dvt.1_Missense_Mutation_p.W343C|ZPLD1_uc011bhg.1_Missense_Mutation_p.W327C	NM_175056	NP_778226	Q8TCW7	ZPLD1_HUMAN	zona pellucida-like domain containing 1	327	Extracellular (Potential).					integral to membrane				ovary(2)|skin(2)|central_nervous_system(1)	5						GGACGACTTGGAGCCCCCAGA	0.507			NA											17	7					5.03518e-11	6.86943e-11	0.007413	1	0
PARP9	83666	broad.mit.edu	37	3	122259566	122259566	+	Missense_Mutation	SNP	C	C	G			TCGA-64-5774-01A-01D-1625-08	TCGA-64-5774-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	df5957d5-20d3-483e-990b-d6369fb990b8	4fb568ce-a4be-46c5-862b-5c681936f30b	g.chr3:122259566C>G	uc010hri.2	-	8	1768	c.1623G>C	c.(1621-1623)CAG>CAC	p.Q541H	PARP9_uc003eff.3_Missense_Mutation_p.Q506H|PARP9_uc011bjs.1_Missense_Mutation_p.Q506H|PARP9_uc003efg.2_Missense_Mutation_p.Q86H|PARP9_uc003efi.2_Missense_Mutation_p.Q506H|PARP9_uc003efh.2_Missense_Mutation_p.Q541H|PARP9_uc003efj.2_Missense_Mutation_p.Q506H	NM_001146102	NP_001139574	Q8IXQ6	PARP9_HUMAN	poly (ADP-ribose) polymerase family, member 9	541					cell migration	cytosol|nucleus	NAD+ ADP-ribosyltransferase activity|protein binding			ovary(1)|pancreas(1)|prostate(1)|skin(1)	4				GBM - Glioblastoma multiforme(114;0.0519)		TGTGGTGGTTCTGGAGACTCA	0.443			NA											6	98					0	0	0.001168	0	0
CEP70	80321	broad.mit.edu	37	3	138219359	138219359	+	Silent	SNP	G	G	A			TCGA-64-5774-01A-01D-1625-08	TCGA-64-5774-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	df5957d5-20d3-483e-990b-d6369fb990b8	4fb568ce-a4be-46c5-862b-5c681936f30b	g.chr3:138219359G>A	uc003esl.2	-	15	1617	c.1419C>T	c.(1417-1419)TTC>TTT	p.F473F	CEP70_uc011bmk.1_Silent_p.F453F|CEP70_uc011bml.1_Silent_p.F455F|CEP70_uc011bmm.1_Silent_p.F321F|CEP70_uc003esm.2_Silent_p.F473F	NM_024491	NP_077817	Q8NHQ1	CEP70_HUMAN	centrosomal protein 70 kDa	473					G2/M transition of mitotic cell cycle	centrosome|cytosol	protein binding			skin(1)	1						ATAACTTTTGGAAGTGAGAAA	0.353			NA											88	125					0	0	0.01441	0	0
LIPH	200879	broad.mit.edu	37	3	185251403	185251403	+	Missense_Mutation	SNP	C	C	T			TCGA-64-5774-01A-01D-1625-08	TCGA-64-5774-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	df5957d5-20d3-483e-990b-d6369fb990b8	4fb568ce-a4be-46c5-862b-5c681936f30b	g.chr3:185251403C>T	uc003fpm.2	-	3	592	c.482G>A	c.(481-483)GGG>GAG	p.G161E	LIPH_uc010hyh.2_Missense_Mutation_p.G161E	NM_139248	NP_640341	Q8WWY8	LIPH_HUMAN	lipase, member H precursor	161					lipid catabolic process	extracellular space|plasma membrane	heparin binding|phospholipase activity			ovary(1)|pancreas(1)	2	all_cancers(143;8.87e-11)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(80;1.31e-21)			TCCAACAAACCCAGATATGTG	0.483			NA											22	47					0	0	0.004656	0	0
GABRG1	2565	broad.mit.edu	37	4	46125866	46125866	+	Missense_Mutation	SNP	C	C	G			TCGA-64-5774-01A-01D-1625-08	TCGA-64-5774-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	df5957d5-20d3-483e-990b-d6369fb990b8	4fb568ce-a4be-46c5-862b-5c681936f30b	g.chr4:46125866C>G	uc003gxb.2	-	1	217	c.65G>C	c.(64-66)AGG>ACG	p.R22T		NM_173536	NP_775807	Q8N1C3	GBRG1_HUMAN	gamma-aminobutyric acid A receptor, gamma 1	22					gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity			ovary(2)	2				Lung(65;0.106)|LUSC - Lung squamous cell carcinoma(721;0.23)		GAAGACCAACCTCACCCCTCT	0.453			NA											5	38					0	0	0.001168	0	0
EPHA5	2044	broad.mit.edu	37	4	66231689	66231689	+	Missense_Mutation	SNP	C	C	G			TCGA-64-5774-01A-01D-1625-08	TCGA-64-5774-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	df5957d5-20d3-483e-990b-d6369fb990b8	4fb568ce-a4be-46c5-862b-5c681936f30b	g.chr4:66231689C>G	uc003hcy.2	-	11	2204	c.2011G>C	c.(2011-2013)GAA>CAA	p.E671Q	EPHA5_uc003hcx.2_Missense_Mutation_p.E603Q|EPHA5_uc003hcz.2_Missense_Mutation_p.E649Q|EPHA5_uc011cah.1_Missense_Mutation_p.E672Q|EPHA5_uc011cai.1_Missense_Mutation_p.E650Q|EPHA5_uc003hda.2_Missense_Mutation_p.E672Q	NM_004439	NP_004430	P54756	EPHA5_HUMAN	ephrin receptor EphA5 isoform a precursor	671	Cytoplasmic (Potential).				cAMP-mediated signaling|neuron development	dendrite|external side of plasma membrane|integral to plasma membrane|neuronal cell body|perinuclear region of cytoplasm|rough endoplasmic reticulum	ATP binding|transmembrane-ephrin receptor activity			lung(19)|stomach(2)|ovary(2)|central_nervous_system(1)	24						CATGATGCTTCTATCTCCTTA	0.358			NA								TSP Lung(17;0.13)			46	40					0	0	0.01441	0	0
MUC7	4589	broad.mit.edu	37	4	71346861	71346861	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5774-01A-01D-1625-08	TCGA-64-5774-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	df5957d5-20d3-483e-990b-d6369fb990b8	4fb568ce-a4be-46c5-862b-5c681936f30b	g.chr4:71346861C>A	uc011cat.1	+	4	688	c.400C>A	c.(400-402)CAG>AAG	p.Q134K	MUC7_uc011cau.1_Missense_Mutation_p.Q134K|MUC7_uc003hfj.2_Missense_Mutation_p.Q134K|uc011cav.1_RNA	NM_001145006	NP_001138478	Q8TAX7	MUC7_HUMAN	mucin 7, secreted precursor	134	Thr-rich.					extracellular region	protein binding			ovary(2)|central_nervous_system(1)|skin(1)	4			Lung(101;0.211)			TTTTCTTCCCCAGAATGCCAC	0.453			NA											38	59					4.32679e-17	6.82989e-17	0.006999	1	0
PDHA2	5161	broad.mit.edu	37	4	96761794	96761794	+	Missense_Mutation	SNP	G	G	A			TCGA-64-5774-01A-01D-1625-08	TCGA-64-5774-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	df5957d5-20d3-483e-990b-d6369fb990b8	4fb568ce-a4be-46c5-862b-5c681936f30b	g.chr4:96761794G>A	uc003htr.3	+	1	556	c.493G>A	c.(493-495)GTC>ATC	p.V165I		NM_005390	NP_005381	P29803	ODPAT_HUMAN	pyruvate dehydrogenase E1 alpha 2 precursor	165					glycolysis	mitochondrial matrix	pyruvate dehydrogenase (acetyl-transferring) activity			central_nervous_system(1)	1		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;1.23e-06)	NADH(DB00157)	CAATGGCATCGTCGGTGCACA	0.507			NA											29	67					0	0	0.00632	0	0
ADH5	128	broad.mit.edu	37	4	100009932	100009932	+	Splice_Site	SNP	C	C	A			TCGA-64-5774-01A-01D-1625-08	TCGA-64-5774-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	df5957d5-20d3-483e-990b-d6369fb990b8	4fb568ce-a4be-46c5-862b-5c681936f30b	g.chr4:100009932C>A	uc003hui.2	-	1	1	c.-79_splice	c.e1-1		ADH5_uc003huk.1_Splice_Site|uc003hum.1_5'Flank|uc003hul.1_5'Flank	NM_000671	NP_000662	P11766	ADHX_HUMAN	class III alcohol dehydrogenase, chi subunit						ethanol oxidation|response to redox state		alcohol dehydrogenase (NAD) activity|electron carrier activity|fatty acid binding|formaldehyde dehydrogenase activity|S-(hydroxymethyl)glutathione dehydrogenase activity|zinc ion binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(123;2.5e-07)	NADH(DB00157)	TGGCGAGCGCCTAGCGAGGGG	0.711			NA											5	15					0.00116845	0.0012826	0.001168	1	0
DNAH5	1767	broad.mit.edu	37	5	13717423	13717424	+	Splice_Site	DNP	CC	CC	AA			TCGA-64-5774-01A-01D-1625-08	TCGA-64-5774-10A-01D-1625-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	df5957d5-20d3-483e-990b-d6369fb990b8	4fb568ce-a4be-46c5-862b-5c681936f30b	g.chr5:13717423_13717424CC>AA	uc003jfd.2	-	73	12747	c.12705_splice	c.e73+1	p.K4235_splice	DNAH5_uc003jfc.2_Splice_Site_p.K403_splice	NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5						microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					CGCGGCAGTACCTTTTTGACAT	0.495			NA							Kartagener_syndrome				13	19					0	0	0.004672	0	0
CDH10	1008	broad.mit.edu	37	5	24511534	24511534	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5774-01A-01D-1625-08	TCGA-64-5774-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	df5957d5-20d3-483e-990b-d6369fb990b8	4fb568ce-a4be-46c5-862b-5c681936f30b	g.chr5:24511534C>A	uc003jgr.1	-	6	1236	c.904G>T	c.(904-906)GCT>TCT	p.A302S	CDH10_uc011cnu.1_RNA	NM_006727	NP_006718	Q9Y6N8	CAD10_HUMAN	cadherin 10, type 2 preproprotein	302	Cadherin 3.|Extracellular (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(6)|pancreas(4)|breast(2)	12				STAD - Stomach adenocarcinoma(35;0.0556)		TCTACTTCAGCATTTTTCCCA	0.428			NA								HNSCC(23;0.051)			26	104					7.92952e-12	1.1055e-11	0.021523	1	0
PAPD4	167153	broad.mit.edu	37	5	78964730	78964730	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5774-01A-01D-1625-08	TCGA-64-5774-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	df5957d5-20d3-483e-990b-d6369fb990b8	4fb568ce-a4be-46c5-862b-5c681936f30b	g.chr5:78964730G>T	uc010jae.1	+	13	1505	c.1087G>T	c.(1087-1089)GCT>TCT	p.A363S	PAPD4_uc003kgb.2_Missense_Mutation_p.A363S|PAPD4_uc010jaf.1_Missense_Mutation_p.A363S|PAPD4_uc003kga.2_Missense_Mutation_p.A359S|PAPD4_uc003kfz.2_Missense_Mutation_p.A320S	NM_001114393	NP_001107865	Q6PIY7	GLD2_HUMAN	PAP associated domain containing 4	363					histone mRNA catabolic process|mRNA processing|RNA polyadenylation	cytoplasm	ATP binding|metal ion binding|polynucleotide adenylyltransferase activity			ovary(1)	1		Lung NSC(167;0.00293)|all_lung(232;0.00323)|Ovarian(174;0.0261)		OV - Ovarian serous cystadenocarcinoma(54;8.61e-47)|Epithelial(54;1.32e-41)|all cancers(79;2.45e-36)		TTTTAGTCCTGCTATACAGCT	0.393			NA											92	163					1.66795e-42	3.35345e-42	0.01441	1	0
EDIL3	10085	broad.mit.edu	37	5	83525673	83525673	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5774-01A-01D-1625-08	TCGA-64-5774-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	df5957d5-20d3-483e-990b-d6369fb990b8	4fb568ce-a4be-46c5-862b-5c681936f30b	g.chr5:83525673C>A	uc003kio.1	-	3	645	c.226G>T	c.(226-228)GGT>TGT	p.G76C	EDIL3_uc003kip.1_Intron	NM_005711	NP_005702	O43854	EDIL3_HUMAN	EGF-like repeats and discoidin I-like	76	EGF-like 2.				cell adhesion|multicellular organismal development	extracellular region	calcium ion binding|integrin binding			skin(2)	2		Lung NSC(167;0.000121)|all_lung(232;0.000154)|Ovarian(174;0.0425)		OV - Ovarian serous cystadenocarcinoma(54;4.3e-40)|Epithelial(54;4.79e-32)|all cancers(79;1.54e-26)		GGAACTTTACCTGCTGAAGTT	0.209			NA											16	51					2.23348e-06	2.73459e-06	0.004007	1	0
SEMA6A	57556	broad.mit.edu	37	5	115783135	115783135	+	Missense_Mutation	SNP	G	G	A			TCGA-64-5774-01A-01D-1625-08	TCGA-64-5774-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	df5957d5-20d3-483e-990b-d6369fb990b8	4fb568ce-a4be-46c5-862b-5c681936f30b	g.chr5:115783135G>A	uc010jck.2	-	19	2976	c.2267C>T	c.(2266-2268)CCC>CTC	p.P756L	SEMA6A_uc003krx.3_Missense_Mutation_p.P773L|SEMA6A_uc011cwe.1_Missense_Mutation_p.P135L|SEMA6A_uc003krv.3_Missense_Mutation_p.P183L|SEMA6A_uc003krw.3_Missense_Mutation_p.P233L|SEMA6A_uc010jcj.2_Missense_Mutation_p.P300L	NM_020796	NP_065847	Q9H2E6	SEM6A_HUMAN	sema domain, transmembrane domain (TM), and	756	Cytoplasmic (Potential).				apoptosis|axon guidance|cell surface receptor linked signaling pathway|cytoskeleton organization|organ morphogenesis	axon|integral to membrane|plasma membrane	receptor activity			ovary(2)	2		all_cancers(142;0.00316)|all_epithelial(76;5.71e-05)|Prostate(80;0.00845)|Ovarian(225;0.0796)|Lung NSC(810;0.171)|all_lung(232;0.203)		OV - Ovarian serous cystadenocarcinoma(64;1.59e-08)|Epithelial(69;2e-08)|all cancers(49;5.7e-08)|COAD - Colon adenocarcinoma(49;0.151)		CTCTGGGGTGGGGAGGGCCGT	0.627			NA											67	74					0	0	0.01441	0	0
PCDHA2	56146	broad.mit.edu	37	5	140176284	140176284	+	Nonsense_Mutation	SNP	G	G	T			TCGA-64-5774-01A-01D-1625-08	TCGA-64-5774-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	df5957d5-20d3-483e-990b-d6369fb990b8	4fb568ce-a4be-46c5-862b-5c681936f30b	g.chr5:140176284G>T	uc003lhd.2	+	1	1841	c.1735G>T	c.(1735-1737)GAG>TAG	p.E579*	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhc.1_Nonsense_Mutation_p.E579*|PCDHA2_uc011czy.1_Nonsense_Mutation_p.E579*	NM_018905	NP_061728	Q9Y5H9	PCDA2_HUMAN	protocadherin alpha 2 isoform 1 precursor	579	Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(4)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGCAGTGAGTGAGCTGGTGCC	0.662			NA											39	34					2.35958e-20	3.81933e-20	0.009718	1	0
PCDHB12	56124	broad.mit.edu	37	5	140588899	140588899	+	Missense_Mutation	SNP	A	A	T			TCGA-64-5774-01A-01D-1625-08	TCGA-64-5774-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	df5957d5-20d3-483e-990b-d6369fb990b8	4fb568ce-a4be-46c5-862b-5c681936f30b	g.chr5:140588899A>T	uc003liz.2	+	1	609	c.420A>T	c.(418-420)TTA>TTT	p.L140F	PCDHB12_uc011dak.1_Intron	NM_018932	NP_061755	Q9Y5F1	PCDBC_HUMAN	protocadherin beta 12 precursor	140	Extracellular (Potential).|Cadherin 2.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			skin(2)|ovary(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			AAATGCTCTTAGAAATCCCAG	0.388			NA											54	48					0	0	0.01441	0	0
PCDHGB2	56103	broad.mit.edu	37	5	140741968	140741968	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5774-01A-01D-1625-08	TCGA-64-5774-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	df5957d5-20d3-483e-990b-d6369fb990b8	4fb568ce-a4be-46c5-862b-5c681936f30b	g.chr5:140741968G>T	uc003ljs.1	+	1	2266	c.2266G>T	c.(2266-2268)GTT>TTT	p.V756F	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGA5_uc003lju.1_5'Flank|PCDHGB2_uc011dar.1_Missense_Mutation_p.V756F|PCDHGA5_uc011das.1_5'Flank	NM_018923	NP_061746	Q9Y5G2	PCDGE_HUMAN	protocadherin gamma subfamily B, 2 isoform 1	756	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CAACCTGTGTGTTGCCTCACA	0.507			NA											80	62					6.11987e-43	1.24351e-42	0.01441	1	0
ADAM19	8728	broad.mit.edu	37	5	156964936	156964936	+	Silent	SNP	G	G	C			TCGA-64-5774-01A-01D-1625-08	TCGA-64-5774-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	df5957d5-20d3-483e-990b-d6369fb990b8	4fb568ce-a4be-46c5-862b-5c681936f30b	g.chr5:156964936G>C	uc003lwz.2	-	4	379	c.315C>G	c.(313-315)ACC>ACG	p.T105T	ADAM19_uc003lww.1_5'UTR|ADAM19_uc011ddr.1_Silent_p.T36T	NM_033274	NP_150377	Q9H013	ADA19_HUMAN	ADAM metallopeptidase domain 19 preproprotein	105					proteolysis	integral to membrane	metalloendopeptidase activity|SH3 domain binding|zinc ion binding			ovary(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)|skin(1)	8	Renal(175;0.00488)	Medulloblastoma(196;0.0359)|all_neural(177;0.14)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			ATTTCCGTGTGGTGGTTTGAG	0.443			NA											14	30					0	0	0.004007	0	0
FAF2	23197	broad.mit.edu	37	5	175923528	175923528	+	Missense_Mutation	SNP	A	A	G			TCGA-64-5774-01A-01D-1625-08	TCGA-64-5774-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	df5957d5-20d3-483e-990b-d6369fb990b8	4fb568ce-a4be-46c5-862b-5c681936f30b	g.chr5:175923528A>G	uc003mej.3	+	8	756	c.703A>G	c.(703-705)ATG>GTG	p.M235V		NM_014613	NP_055428	Q96CS3	FAF2_HUMAN	UBX domain containing 8	235					response to unfolded protein	endoplasmic reticulum|lipid particle	protein binding			ovary(1)	1						ATTCCTGGCCATGATTATGCT	0.463			NA											27	35					0	0	0.012213	0	0
C6orf89	221477	broad.mit.edu	37	6	36882185	36882185	+	Missense_Mutation	SNP	G	G	C			TCGA-64-5774-01A-01D-1625-08	TCGA-64-5774-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	df5957d5-20d3-483e-990b-d6369fb990b8	4fb568ce-a4be-46c5-862b-5c681936f30b	g.chr6:36882185G>C	uc003omx.2	+	5	813	c.529G>C	c.(529-531)GAG>CAG	p.E177Q	C6orf89_uc003omv.2_Missense_Mutation_p.E71Q|C6orf89_uc003omw.2_Missense_Mutation_p.E184Q|C6orf89_uc011dtr.1_Missense_Mutation_p.E71Q|C6orf89_uc003omy.2_Missense_Mutation_p.E11Q	NM_152734	NP_689947	Q6UWU4	CF089_HUMAN	hypothetical protein LOC221477	177						integral to membrane				ovary(1)	1						AAGGAAATTTGAGAGGCTCCA	0.527			NA											27	31					0	0	0.009535	0	0
LRRC1	55227	broad.mit.edu	37	6	53785527	53785527	+	Missense_Mutation	SNP	G	G	C			TCGA-64-5774-01A-01D-1625-08	TCGA-64-5774-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	df5957d5-20d3-483e-990b-d6369fb990b8	4fb568ce-a4be-46c5-862b-5c681936f30b	g.chr6:53785527G>C	uc003pcd.1	+	13	1661	c.1384G>C	c.(1384-1386)GAG>CAG	p.E462Q		NM_018214	NP_060684	Q9BTT6	LRRC1_HUMAN	leucine rich repeat containing 1	462						cytoplasm|membrane				ovary(1)	1	Lung NSC(77;0.0147)			BRCA - Breast invasive adenocarcinoma(397;0.0745)		CCGATTTGTGGAGGATGAGAA	0.443			NA											13	24					0	0	0.013537	0	0
GRIK2	2898	broad.mit.edu	37	6	102516291	102516291	+	Nonsense_Mutation	SNP	A	A	T			TCGA-64-5774-01A-01D-1625-08	TCGA-64-5774-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	df5957d5-20d3-483e-990b-d6369fb990b8	4fb568ce-a4be-46c5-862b-5c681936f30b	g.chr6:102516291A>T	uc003pqp.3	+	16	2881	c.2632A>T	c.(2632-2634)AAG>TAG	p.K878*	GRIK2_uc003pqo.3_3'UTR|GRIK2_uc010kcw.2_3'UTR	NM_021956	NP_068775	Q13002	GRIK2_HUMAN	glutamate receptor, ionotropic, kainate 2	878	Cytoplasmic (Potential).				glutamate signaling pathway|induction of programmed cell death in response to chemical stimulus|neuron apoptosis|positive regulation of synaptic transmission|regulation of short-term neuronal synaptic plasticity	cell junction|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			ovary(2)|pancreas(1)|breast(1)|skin(1)	5		all_cancers(76;1.19e-07)|Acute lymphoblastic leukemia(125;6.17e-11)|all_hematologic(75;6.01e-08)|all_epithelial(87;0.0121)|Colorectal(196;0.14)		all cancers(137;0.112)|BRCA - Breast invasive adenocarcinoma(108;0.124)|GBM - Glioblastoma multiforme(226;0.206)	L-Glutamic Acid(DB00142)	GTTAAAACATAAGCCACAGGC	0.413			NA											27	16					0	0	0.00632	0	0
RTN4IP1	84816	broad.mit.edu	37	6	107019974	107019974	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5774-01A-01D-1625-08	TCGA-64-5774-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	df5957d5-20d3-483e-990b-d6369fb990b8	4fb568ce-a4be-46c5-862b-5c681936f30b	g.chr6:107019974C>A	uc003prj.2	-	9	1565	c.1088G>T	c.(1087-1089)CGG>CTG	p.R363L	RTN4IP1_uc010kdd.2_3'UTR|RTN4IP1_uc003prk.2_Missense_Mutation_p.R263L	NM_032730	NP_116119	Q8WWV3	RT4I1_HUMAN	reticulon 4 interacting protein 1 precursor	363						mitochondrion	oxidoreductase activity|zinc ion binding				0	Breast(9;0.0107)|all_epithelial(6;0.14)	all_cancers(87;9.45e-05)|Acute lymphoblastic leukemia(125;2.13e-07)|all_hematologic(75;5.28e-06)|all_epithelial(87;0.0144)	Epithelial(6;0.000873)|all cancers(7;0.00363)|BRCA - Breast invasive adenocarcinoma(8;0.00721)|OV - Ovarian serous cystadenocarcinoma(5;0.0394)	all cancers(137;0.113)|BRCA - Breast invasive adenocarcinoma(108;0.127)|Epithelial(106;0.144)		AATAACTGGCCGGATCTGTAA	0.418			NA											40	13					1.57019e-19	2.52023e-19	0.007835	1	0
DNAH11	8701	broad.mit.edu	37	7	21628977	21628977	+	Missense_Mutation	SNP	T	T	C			TCGA-64-5774-01A-01D-1625-08	TCGA-64-5774-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	df5957d5-20d3-483e-990b-d6369fb990b8	4fb568ce-a4be-46c5-862b-5c681936f30b	g.chr7:21628977T>C	uc003svc.2	+	12	2156	c.2125T>C	c.(2125-2127)TTC>CTC	p.F709L		NM_003777	NP_003768	Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	709	Stem (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(8)|large_intestine(3)|pancreas(3)|central_nervous_system(1)	15						CTTGGTTAAATTCAGTGCCAT	0.323			NA							Kartagener_syndrome				21	63					0	0	0.004656	0	0
NSUN5P2	260294	broad.mit.edu	37	7	72420448	72420448	+	Missense_Mutation	SNP	C	C	G	rs400282	byFrequency	TCGA-64-5774-01A-01D-1625-08	TCGA-64-5774-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	df5957d5-20d3-483e-990b-d6369fb990b8	4fb568ce-a4be-46c5-862b-5c681936f30b	g.chr7:72420448C>G	uc003twn.2	-	7	852	c.140G>C	c.(139-141)TGG>TCG	p.W47S	POM121_uc010lam.1_3'UTR|NSUN5P2_uc003twl.2_RNA|NSUN5P2_uc003twm.2_Missense_Mutation_p.W47S|NSUN5P2_uc003two.2_Missense_Mutation_p.W47S|NSUN5P2_uc003twq.2_Missense_Mutation_p.W47S|NSUN5P2_uc010lan.1_5'UTR|NSUN5P2_uc003twp.2_Missense_Mutation_p.W47S	NM_032158	NP_115534			NOL1/NOP2/Sun domain family, member 5C isoform												0						CACAGGCATCCATGACATGGG	0.612			NA											4	47					0	0	0.001168	0	0
MUC17	140453	broad.mit.edu	37	7	100682994	100682994	+	Missense_Mutation	SNP	C	C	G			TCGA-64-5774-01A-01D-1625-08	TCGA-64-5774-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	df5957d5-20d3-483e-990b-d6369fb990b8	4fb568ce-a4be-46c5-862b-5c681936f30b	g.chr7:100682994C>G	uc003uxp.1	+	3	8350	c.8297C>G	c.(8296-8298)TCT>TGT	p.S2766C	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	2766	Extracellular (Potential).|Ser-rich.|59 X approximate tandem repeats.|44.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					GTGGCCAGTTCTGAGGCTAGC	0.493			NA											154	131					0	0	0.01441	0	0
VGF	7425	broad.mit.edu	37	7	100807902	100807902	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5774-01A-01D-1625-08	TCGA-64-5774-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	df5957d5-20d3-483e-990b-d6369fb990b8	4fb568ce-a4be-46c5-862b-5c681936f30b	g.chr7:100807902G>T	uc003uxx.3	-	2	441	c.223C>A	c.(223-225)CAG>AAG	p.Q75K		NM_003378	NP_003369	O15240	VGF_HUMAN	VGF nerve growth factor inducible precursor	75					response to cAMP	extracellular space|transport vesicle	growth factor activity				0	Lung NSC(181;0.168)|all_lung(186;0.215)					TCCACGCCCTGGAAAAGCTCT	0.736			NA											3	3					1.23904e-05	1.46992e-05	0.014758	1	0
ST7	7982	broad.mit.edu	37	7	116870061	116870061	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5774-01A-01D-1625-08	TCGA-64-5774-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	df5957d5-20d3-483e-990b-d6369fb990b8	4fb568ce-a4be-46c5-862b-5c681936f30b	g.chr7:116870061G>T	uc011knn.1	+	14	1593	c.1588G>T	c.(1588-1590)GTT>TTT	p.V530F	ST7_uc003vio.2_3'UTR|ST7_uc003viq.2_3'UTR|ST7_uc011knm.1_3'UTR|ST7_uc003vir.2_3'UTR	NM_021908	NP_068708	Q9NRC1	ST7_HUMAN	suppression of tumorigenicity 7 isoform b	Error:Variant_position_missing_in_Q9NRC1_after_alignment						integral to membrane	binding			central_nervous_system(1)|skin(1)	2	all_cancers(3;3.88e-07)|all_epithelial(6;3.42e-07)|Lung NSC(10;0.00072)|all_lung(10;0.000847)		STAD - Stomach adenocarcinoma(10;0.000512)	LUSC - Lung squamous cell carcinoma(290;0.133)		ATTAAAAGCTGTTTTTGTTGT	0.333			NA											2	3					0.00909568	0.00954547	0.009096	1	0
WNT2	7472	broad.mit.edu	37	7	116955207	116955207	+	Missense_Mutation	SNP	C	C	T			TCGA-64-5774-01A-01D-1625-08	TCGA-64-5774-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	df5957d5-20d3-483e-990b-d6369fb990b8	4fb568ce-a4be-46c5-862b-5c681936f30b	g.chr7:116955207C>T	uc003viz.2	-	3	806	c.506G>A	c.(505-507)CGC>CAC	p.R169H	WNT2_uc003vja.2_Missense_Mutation_p.R73H	NM_003391	NP_003382	P09544	WNT2_HUMAN	wingless-type MMTV integration site family	169					atrial cardiac muscle tissue morphogenesis|canonical Wnt receptor signaling pathway|cardiac epithelial to mesenchymal transition|cellular response to retinoic acid|cellular response to transforming growth factor beta stimulus|dorsal/ventral axis specification|iris morphogenesis|labyrinthine layer blood vessel development|lens development in camera-type eye|lung induction|mammary gland epithelium development|neuron differentiation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cardiac muscle cell proliferation|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of fibroblast proliferation|positive regulation of mesenchymal cell proliferation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|Wnt receptor signaling pathway, calcium modulating pathway	cytoplasm|extracellular space|proteinaceous extracellular matrix	cytokine activity|frizzled binding|frizzled-2 binding|signal transducer activity	p.R169C(1)		breast(2)|central_nervous_system(2)|ovary(1)|lung(1)|skin(1)	7	all_epithelial(6;2.24e-06)|Lung NSC(10;0.000936)|all_lung(10;0.00109)		STAD - Stomach adenocarcinoma(10;0.000512)	LUSC - Lung squamous cell carcinoma(290;0.133)		CACAAATGCGCGGGCAAATTT	0.438			NA											31	69					0	0	0.009535	0	0
PLXNA4	91584	broad.mit.edu	37	7	131912276	131912276	+	Missense_Mutation	SNP	C	C	T			TCGA-64-5774-01A-01D-1625-08	TCGA-64-5774-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	df5957d5-20d3-483e-990b-d6369fb990b8	4fb568ce-a4be-46c5-862b-5c681936f30b	g.chr7:131912276C>T	uc003vra.3	-	7	2045	c.1816G>A	c.(1816-1818)GTG>ATG	p.V606M		NM_020911	NP_065962	Q9HCM2	PLXA4_HUMAN	plexin A4 isoform 1	606	Extracellular (Potential).					integral to membrane|intracellular|plasma membrane				ovary(1)	1						TGATTGCCCACGACCAGCCCA	0.587			NA											11	27					0	0	0.008291	0	0
LOC93432	93432	broad.mit.edu	37	7	141833894	141833894	+	Missense_Mutation	SNP	G	G	A			TCGA-64-5774-01A-01D-1625-08	TCGA-64-5774-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	df5957d5-20d3-483e-990b-d6369fb990b8	4fb568ce-a4be-46c5-862b-5c681936f30b	g.chr7:141833894G>A	uc003vwz.2	+	7	748	c.689G>A	c.(688-690)CGC>CAC	p.R230H		NR_003715				RecName: Full=Putative maltase-glucoamylase-like protein LOC93432;												0						CAGCAGTACCGCCACAATATG	0.587			NA											7	12					0	0	0.008291	0	0
FAM131B	9715	broad.mit.edu	37	7	143055984	143055984	+	Silent	SNP	C	C	G			TCGA-64-5774-01A-01D-1625-08	TCGA-64-5774-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	df5957d5-20d3-483e-990b-d6369fb990b8	4fb568ce-a4be-46c5-862b-5c681936f30b	g.chr7:143055984C>G	uc003wct.2	-	4	2024	c.318G>C	c.(316-318)GTG>GTC	p.V106V	FAM131B_uc010loz.2_Silent_p.V74V|FAM131B_uc003wcu.3_Silent_p.V106V|FAM131B_uc010lpa.2_Silent_p.V134V|ZYX_uc011ktd.1_5'Flank	NM_014690	NP_055505	Q86XD5	F131B_HUMAN	hypothetical protein LOC9715 isoform b	106											0	Melanoma(164;0.205)					TATCCCTGCGCACGGACTCAT	0.592			NA											15	22					0	0	0.003163	0	0
DLGAP2	9228	broad.mit.edu	37	8	1496873	1496873	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5774-01A-01D-1625-08	TCGA-64-5774-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	df5957d5-20d3-483e-990b-d6369fb990b8	4fb568ce-a4be-46c5-862b-5c681936f30b	g.chr8:1496873C>A	uc003wpl.2	+	2	111	c.14C>A	c.(13-15)TCC>TAC	p.S5Y	DLGAP2_uc003wpm.2_Missense_Mutation_p.S5Y	NM_004745	NP_004736	Q9P1A6	DLGP2_HUMAN	discs large-associated protein 2	84					neuron-neuron synaptic transmission	cell junction|neurofilament|postsynaptic density|postsynaptic membrane	protein binding				0		Ovarian(12;0.0271)|Hepatocellular(245;0.0838)|Colorectal(14;0.0846)		BRCA - Breast invasive adenocarcinoma(11;0.000169)|READ - Rectum adenocarcinoma(644;0.171)		AAGGGCCTTTCCGGAAGTCGG	0.687			NA											6	9					2.0095e-06	2.4923e-06	0.001984	1	0
DLGAP2	9228	broad.mit.edu	37	8	1497432	1497432	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5774-01A-01D-1625-08	TCGA-64-5774-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	df5957d5-20d3-483e-990b-d6369fb990b8	4fb568ce-a4be-46c5-862b-5c681936f30b	g.chr8:1497432C>A	uc003wpl.2	+	2	670	c.573C>A	c.(571-573)CAC>CAA	p.H191Q	DLGAP2_uc003wpm.2_Missense_Mutation_p.H191Q	NM_004745	NP_004736	Q9P1A6	DLGP2_HUMAN	discs large-associated protein 2	270					neuron-neuron synaptic transmission	cell junction|neurofilament|postsynaptic density|postsynaptic membrane	protein binding				0		Ovarian(12;0.0271)|Hepatocellular(245;0.0838)|Colorectal(14;0.0846)		BRCA - Breast invasive adenocarcinoma(11;0.000169)|READ - Rectum adenocarcinoma(644;0.171)		ACGCCCACCACGCCAAGCACA	0.667			NA											10	8					0.00829132	0.00879801	0.008291	1	0
DLGAP2	9228	broad.mit.edu	37	8	1497586	1497586	+	Missense_Mutation	SNP	G	G	T	rs145069342	by1000genomes	TCGA-64-5774-01A-01D-1625-08	TCGA-64-5774-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	df5957d5-20d3-483e-990b-d6369fb990b8	4fb568ce-a4be-46c5-862b-5c681936f30b	g.chr8:1497586G>T	uc003wpl.2	+	2	824	c.727G>T	c.(727-729)GTG>TTG	p.V243L	DLGAP2_uc003wpm.2_Missense_Mutation_p.V243L	NM_004745	NP_004736	Q9P1A6	DLGP2_HUMAN	discs large-associated protein 2	322					neuron-neuron synaptic transmission	cell junction|neurofilament|postsynaptic density|postsynaptic membrane	protein binding				0		Ovarian(12;0.0271)|Hepatocellular(245;0.0838)|Colorectal(14;0.0846)		BRCA - Breast invasive adenocarcinoma(11;0.000169)|READ - Rectum adenocarcinoma(644;0.171)		CCTGGGCCCCGTGGCCCACTG	0.677			NA											47	67					4.6707e-30	9.01115e-30	0.01441	1	0
CSMD1	64478	broad.mit.edu	37	8	3087578	3087578	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5774-01A-01D-1625-08	TCGA-64-5774-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	df5957d5-20d3-483e-990b-d6369fb990b8	4fb568ce-a4be-46c5-862b-5c681936f30b	g.chr8:3087578G>T	uc011kwk.1	-	27	4722	c.4332C>A	c.(4330-4332)GAC>GAA	p.D1444E	CSMD1_uc011kwj.1_Missense_Mutation_p.D836E|CSMD1_uc003wqe.2_Missense_Mutation_p.D600E	NM_033225	NP_150094	Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1 precursor	1444	Extracellular (Potential).|Sushi 8.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		ATGTAGGAGGGTCTGGTTGCC	0.438			NA											6	43					3.59834e-05	4.16535e-05	0.001168	1	0
NRG1	3084	broad.mit.edu	37	8	32453386	32453386	+	Silent	SNP	G	G	T	rs147561043		TCGA-64-5774-01A-01D-1625-08	TCGA-64-5774-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	df5957d5-20d3-483e-990b-d6369fb990b8	4fb568ce-a4be-46c5-862b-5c681936f30b	g.chr8:32453386G>T	uc003xiv.2	+	2	658	c.141G>T	c.(139-141)TCG>TCT	p.S47S	NRG1_uc003xip.2_Silent_p.S262S|NRG1_uc003xir.2_Silent_p.S47S|NRG1_uc010lvl.2_Silent_p.S47S|NRG1_uc010lvm.2_Silent_p.S47S|NRG1_uc010lvn.2_Silent_p.S47S|NRG1_uc003xis.2_Silent_p.S47S|NRG1_uc011lbf.1_Silent_p.S47S|NRG1_uc010lvo.2_Silent_p.S47S|NRG1_uc003xiu.2_Silent_p.S47S|NRG1_uc003xiw.2_Silent_p.S47S|NRG1_uc003xit.2_Silent_p.S47S|NRG1_uc010lvr.2_5'UTR|NRG1_uc010lvs.2_5'UTR|NRG1_uc010lvp.2_Silent_p.S13S|NRG1_uc010lvq.2_Silent_p.S13S	NM_013964	NP_039258	Q02297	NRG1_HUMAN	neuregulin 1 isoform HRG-alpha	47	Extracellular (Potential).|Ig-like C2-type.				activation of transmembrane receptor protein tyrosine kinase activity|anti-apoptosis|cardiac muscle cell differentiation|cell communication|cell proliferation|cellular protein complex disassembly|embryo development|mammary gland development|negative regulation of cardiac muscle cell apoptosis|negative regulation of secretion|negative regulation of transcription, DNA-dependent|nervous system development|neural crest cell development|Notch signaling pathway|positive regulation of cardiac muscle cell proliferation|positive regulation of cell adhesion|positive regulation of cell growth|positive regulation of striated muscle cell differentiation|regulation of protein heterodimerization activity|regulation of protein homodimerization activity|transmembrane receptor protein tyrosine kinase signaling pathway|ventricular cardiac muscle cell differentiation|wound healing|wound healing	apical plasma membrane|extracellular region|extracellular space|integral to membrane|nucleus|plasma membrane	cytokine activity|ErbB-3 class receptor binding|growth factor activity|growth factor activity|protein binding|protein tyrosine kinase activator activity|receptor tyrosine kinase binding|transcription cofactor activity|transmembrane receptor protein tyrosine kinase activator activity				0		Breast(100;0.203)		KIRC - Kidney renal clear cell carcinoma(67;0.0768)|Kidney(114;0.0943)		GCCAGGAATCGGCTGCAGGTT	0.413			NA											57	34					9.59835e-30	1.81513e-29	0.01441	1	0
POTEA	340441	broad.mit.edu	37	8	43159892	43159892	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5774-01A-01D-1625-08	TCGA-64-5774-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	df5957d5-20d3-483e-990b-d6369fb990b8	4fb568ce-a4be-46c5-862b-5c681936f30b	g.chr8:43159892C>A	uc003xpz.1	+	6	927	c.884C>A	c.(883-885)TCT>TAT	p.S295Y	POTEA_uc003xqa.1_Missense_Mutation_p.S249Y	NM_001005365	NP_001005365	Q6S8J7	POTEA_HUMAN	POTE ankyrin domain family, member A isoform 2	295										ovary(1)	1						CCAAACAACTCTTCTGGAAAT	0.199			NA											40	35					1.15183e-24	2.03704e-24	0.009718	1	0
CHD7	55636	broad.mit.edu	37	8	61777733	61777734	+	Missense_Mutation	DNP	GG	GG	TT			TCGA-64-5774-01A-01D-1625-08	TCGA-64-5774-10A-01D-1625-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	df5957d5-20d3-483e-990b-d6369fb990b8	4fb568ce-a4be-46c5-862b-5c681936f30b	g.chr8:61777733_61777734GG>TT	uc003xue.2	+	38	8712_8713	c.8235_8236GG>TT	c.(8233-8238)CTGGTG>CTTTTG	p.V2746L		NM_017780	NP_060250	Q9P2D1	CHD7_HUMAN	chromodomain helicase DNA binding protein 7	2746					central nervous system development|chromatin modification|cognition|cranial nerve development|face development|heart morphogenesis|in utero embryonic development|inner ear morphogenesis|nose development|palate development|regulation of growth hormone secretion|regulation of transcription, DNA-dependent|retina development in camera-type eye|skeletal system development|T cell differentiation|transcription, DNA-dependent	nucleus	ATP binding|chromatin binding|DNA binding|helicase activity			ovary(4)|large_intestine(1)|central_nervous_system(1)|lung(1)|breast(1)|pancreas(1)	9		all_cancers(86;0.2)|all_lung(136;0.0402)|Lung NSC(129;0.0459)|all_epithelial(80;0.0477)	BRCA - Breast invasive adenocarcinoma(89;0.143)			ACCCTTTGCTGGTGAACAGCCT	0.604			NA											4	6					0	0	0.004672	0	0
LRRCC1	85444	broad.mit.edu	37	8	86042158	86042158	+	Missense_Mutation	SNP	G	G	A			TCGA-64-5774-01A-01D-1625-08	TCGA-64-5774-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	df5957d5-20d3-483e-990b-d6369fb990b8	4fb568ce-a4be-46c5-862b-5c681936f30b	g.chr8:86042158G>A	uc003ycw.2	+	11	1785	c.1631G>A	c.(1630-1632)AGA>AAA	p.R544K	LRRCC1_uc010lzz.1_RNA|LRRCC1_uc010maa.1_Missense_Mutation_p.R245K|LRRCC1_uc003ycx.2_Missense_Mutation_p.R451K|LRRCC1_uc003ycy.2_Missense_Mutation_p.R524K	NM_033402	NP_208325	Q9C099	LRCC1_HUMAN	sodium channel associated protein 2 isoform a	544	Potential.				cell division|mitosis	centriole|nucleus					0						ACTCAGATAAGACTGATCCAA	0.373			NA											4	99					0	0	0.009096	0	0
PKHD1L1	93035	broad.mit.edu	37	8	110454418	110454418	+	Missense_Mutation	SNP	A	A	T			TCGA-64-5774-01A-01D-1625-08	TCGA-64-5774-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	df5957d5-20d3-483e-990b-d6369fb990b8	4fb568ce-a4be-46c5-862b-5c681936f30b	g.chr8:110454418A>T	uc003yne.2	+	35	4491	c.4387A>T	c.(4387-4389)ACA>TCA	p.T1463S		NM_177531	NP_803875	Q86WI1	PKHL1_HUMAN	fibrocystin L precursor	1463	Extracellular (Potential).|IPT/TIG 7.				immune response	cytosol|extracellular space|integral to membrane	receptor activity			ovary(9)|central_nervous_system(2)|large_intestine(1)|breast(1)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			ACAAAAATCTACATCAGGTAT	0.328			NA								HNSCC(38;0.096)			34	7					0	0	0.015359	0	0
KIAA0196	9897	broad.mit.edu	37	8	126085512	126085512	+	Silent	SNP	G	G	A			TCGA-64-5774-01A-01D-1625-08	TCGA-64-5774-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	df5957d5-20d3-483e-990b-d6369fb990b8	4fb568ce-a4be-46c5-862b-5c681936f30b	g.chr8:126085512G>A	uc003yrt.2	-	9	1362	c.1033C>T	c.(1033-1035)CTA>TTA	p.L345L	KIAA0196_uc011lir.1_Silent_p.L197L	NM_014846	NP_055661	Q12768	STRUM_HUMAN	strumpellin	345					cell death	WASH complex				ovary(2)	2	Ovarian(258;0.0028)|all_neural(195;0.00294)|Hepatocellular(40;0.108)		STAD - Stomach adenocarcinoma(47;0.000918)|COAD - Colon adenocarcinoma(160;0.205)			CCTTCTTTTAGAAATTGCTGC	0.398			NA											13	56					0	0	0.003163	0	0
FBXO10	26267	broad.mit.edu	37	9	37537272	37537272	+	Silent	SNP	C	C	T			TCGA-64-5774-01A-01D-1625-08	TCGA-64-5774-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	df5957d5-20d3-483e-990b-d6369fb990b8	4fb568ce-a4be-46c5-862b-5c681936f30b	g.chr9:37537272C>T	uc004aab.2	-	3	1303	c.1254G>A	c.(1252-1254)AAG>AAA	p.K418K	FBXO10_uc004aac.2_Silent_p.K434K|FBXO10_uc004aad.2_Intron	NM_012166	NP_036298	Q9UK96	FBX10_HUMAN	F-box protein 10	418						ubiquitin ligase complex	ubiquitin-protein ligase activity			lung(5)	5				GBM - Glioblastoma multiforme(29;0.0107)		CCATGGCCTCCTTATCCTTCT	0.627			NA											13	20					0	0	0.013537	0	0
TMEM2	23670	broad.mit.edu	37	9	74340552	74340552	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5774-01A-01D-1625-08	TCGA-64-5774-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	df5957d5-20d3-483e-990b-d6369fb990b8	4fb568ce-a4be-46c5-862b-5c681936f30b	g.chr9:74340552G>T	uc011lsa.1	-	11	2663	c.2123C>A	c.(2122-2124)CCA>CAA	p.P708Q	TMEM2_uc010mos.2_Missense_Mutation_p.P645Q|TMEM2_uc011lsb.1_RNA	NM_013390	NP_037522	Q9UHN6	TMEM2_HUMAN	transmembrane protein 2 isoform a	708						integral to membrane				ovary(2)	2		all_epithelial(88;4.56e-14)|Myeloproliferative disorder(762;0.0255)		GBM - Glioblastoma multiforme(74;7.45e-21)|OV - Ovarian serous cystadenocarcinoma(323;1.02e-16)		AGTGAGTTCTGGTTTTGCCAA	0.378			NA											24	47					7.87624e-14	1.16617e-13	0.016522	1	0
FAM75C1	441452	broad.mit.edu	37	9	90535445	90535445	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5774-01A-01D-1625-08	TCGA-64-5774-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	df5957d5-20d3-483e-990b-d6369fb990b8	4fb568ce-a4be-46c5-862b-5c681936f30b	g.chr9:90535445C>A	uc010mqi.2	+	4	652	c.623C>A	c.(622-624)CCC>CAC	p.P208H	FAM75C1_uc004apq.3_Missense_Mutation_p.P191H	NM_001145124	NP_001138596			family with sequence similarity 75, member C1												0						CTAGAACGCCCCTCACCCGAG	0.627			NA											53	102					4.88482e-21	8.11306e-21	0.01441	1	0
LHX3	8022	broad.mit.edu	37	9	139091689	139091689	+	Missense_Mutation	SNP	T	T	C			TCGA-64-5774-01A-01D-1625-08	TCGA-64-5774-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	df5957d5-20d3-483e-990b-d6369fb990b8	4fb568ce-a4be-46c5-862b-5c681936f30b	g.chr9:139091689T>C	uc004cha.2	-	3	386	c.289A>G	c.(289-291)ATC>GTC	p.I97V	LHX3_uc004cgz.2_Missense_Mutation_p.I102V	NM_178138	NP_835258	Q9UBR4	LHX3_HUMAN	LIM homeobox protein 3 isoform a	97	LIM zinc-binding 2.				inner ear development|organ morphogenesis|positive regulation of transcription, DNA-dependent	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(1)	1		Myeloproliferative disorder(178;0.0511)		Epithelial(140;8.43e-08)|OV - Ovarian serous cystadenocarcinoma(145;1.26e-07)		GTGGGCGGGATGCCCAGCTGG	0.721			NA											7	3					0	0	0.001984	0	0
FAM47A	158724	broad.mit.edu	37	X	34150162	34150162	+	Silent	SNP	G	G	T			TCGA-64-5774-01A-01D-1625-08	TCGA-64-5774-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	df5957d5-20d3-483e-990b-d6369fb990b8	4fb568ce-a4be-46c5-862b-5c681936f30b	g.chrX:34150162G>T	uc004ddg.2	-	1	267	c.234C>A	c.(232-234)CTC>CTA	p.L78L		NM_203408	NP_981953	Q5JRC9	FA47A_HUMAN	hypothetical protein LOC158724	78										ovary(4)|central_nervous_system(1)	5						ATATTTTGGGGAGTAAAAACT	0.542			NA											20	45					2.94398e-08	3.85137e-08	0.007413	1	0
NXF2B	728343	broad.mit.edu	37	X	101623732	101623732	+	Silent	SNP	C	C	T			TCGA-64-5774-01A-01D-1625-08	TCGA-64-5774-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	df5957d5-20d3-483e-990b-d6369fb990b8	4fb568ce-a4be-46c5-862b-5c681936f30b	g.chrX:101623732C>T	uc004ejb.3	-	19	2502	c.630G>A	c.(628-630)AAG>AAA	p.K210K	NXF2B_uc004eiz.3_Silent_p.K122K|NXF2B_uc004eja.3_Silent_p.K210K|NXF2_uc004eiy.3_Silent_p.K210K	NM_001099686	NP_001093156	Q9GZY0	NXF2_HUMAN	nuclear RNA export factor 2B	210					mRNA export from nucleus|multicellular organismal development	actin cytoskeleton|cytoplasm|nuclear RNA export factor complex	nucleocytoplasmic transporter activity|nucleotide binding|RNA binding			ovary(1)	1						TTTGGCCTGGCTTCAACTTAT	0.483			NA											18	33					0	0	0.019004	0	0
GPR112	139378	broad.mit.edu	37	X	135428901	135428901	+	Silent	SNP	T	T	C			TCGA-64-5774-01A-01D-1625-08	TCGA-64-5774-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	df5957d5-20d3-483e-990b-d6369fb990b8	4fb568ce-a4be-46c5-862b-5c681936f30b	g.chrX:135428901T>C	uc004ezu.1	+	6	3327	c.3036T>C	c.(3034-3036)ACT>ACC	p.T1012T	GPR112_uc010nsb.1_Silent_p.T807T|GPR112_uc010nsc.1_Silent_p.T779T	NM_153834	NP_722576	Q8IZF6	GP112_HUMAN	G-protein coupled receptor 112	1012	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(5)|large_intestine(2)|skin(2)|lung(1)|breast(1)|pancreas(1)	12	Acute lymphoblastic leukemia(192;0.000127)					TGCCTGTTACTCATATGTTCT	0.507			NA											103	19					0	0	0.01441	0	0
MAMLD1	10046	broad.mit.edu	37	X	149638350	149638350	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5774-01A-01D-1625-08	TCGA-64-5774-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	df5957d5-20d3-483e-990b-d6369fb990b8	4fb568ce-a4be-46c5-862b-5c681936f30b	g.chrX:149638350G>T	uc004fee.1	+	3	581	c.505G>T	c.(505-507)GTG>TTG	p.V169L	MAMLD1_uc011mxt.1_Missense_Mutation_p.V131L|MAMLD1_uc011mxu.1_Missense_Mutation_p.V144L|MAMLD1_uc011mxv.1_Missense_Mutation_p.V144L|MAMLD1_uc011mxw.1_Missense_Mutation_p.V96L	NM_005491	NP_005482	Q13495	MAMD1_HUMAN	mastermind-like domain containing 1	169					male gonad development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus					0	Acute lymphoblastic leukemia(192;6.56e-05)					AATCAACAGCGTGCCGGCTGT	0.478			NA											42	5					1.07121e-22	1.82679e-22	0.006999	1	0
MAGEA6	4105	broad.mit.edu	37	X	151869776	151869776	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5774-01A-01D-1625-08	TCGA-64-5774-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	df5957d5-20d3-483e-990b-d6369fb990b8	4fb568ce-a4be-46c5-862b-5c681936f30b	g.chrX:151869776G>T	uc004ffq.1	+	3	660	c.466G>T	c.(466-468)GAT>TAT	p.D156Y	MAGEA6_uc004ffr.1_Missense_Mutation_p.D156Y|MAGEA2_uc010nto.2_Intron	NM_005363	NP_005354	P43360	MAGA6_HUMAN	melanoma antigen family A, 6	156	MAGE.						protein binding				0	Acute lymphoblastic leukemia(192;6.56e-05)					CAAAGCTTCCGATTCCTTGCA	0.552			NA											61	9					1.27862e-28	2.34823e-28	0.01441	1	0
AMELY	266	broad.mit.edu	37	Y	6736166	6736166	+	Missense_Mutation	SNP	A	A	T			TCGA-64-5774-01A-01D-1625-08	TCGA-64-5774-10A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	df5957d5-20d3-483e-990b-d6369fb990b8	4fb568ce-a4be-46c5-862b-5c681936f30b	g.chrY:6736166A>T	uc004fra.1	-	5	539	c.527T>A	c.(526-528)ATG>AAG	p.M176K	AMELY_uc004fqz.2_Missense_Mutation_p.M162K	NM_001143	NP_001134	Q99218	AMELY_HUMAN	amelogenin, Y-linked precursor	176					biomineral tissue development	proteinaceous extracellular matrix	structural constituent of tooth enamel				0						CAGGGGGAACATTGGAGGCAG	0.627			NA											2	2					0	0	0.004672	0	0
SCUBE2	57758	broad.mit.edu	37	11	9096031	9096031	+	Frame_Shift_Del	DEL	C	C	-			TCGA-64-5774-01A-01D-1625-08	TCGA-64-5774-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	df5957d5-20d3-483e-990b-d6369fb990b8	4fb568ce-a4be-46c5-862b-5c681936f30b	g.chr11:9096031delC	uc001mhh.1	-	4	594	c.514delG	c.(514-516)GAAfs	p.E172fs	SCUBE2_uc001mhi.1_Frame_Shift_Del_p.E172fs|SCUBE2_uc001mhj.1_Frame_Shift_Del_p.E172fs	NM_020974	NP_066025	Q9NQ36	SCUB2_HUMAN	CEGP1 protein precursor	172						extracellular region	calcium ion binding			ovary(1)|skin(1)	2				all cancers(16;8.57e-09)|Epithelial(150;4.42e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0116)		GAGGTACCTTCCGAGCGGTGA	0.532			NA											7	91	---	---	---	---	NA	NA	NA	NA	NA
KCNK10	54207	broad.mit.edu	37	14	88652098	88652098	+	Frame_Shift_Del	DEL	G	G	-			TCGA-64-5774-01A-01D-1625-08	TCGA-64-5774-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	df5957d5-20d3-483e-990b-d6369fb990b8	4fb568ce-a4be-46c5-862b-5c681936f30b	g.chr14:88652098delG	uc001xwo.2	-	7	1855	c.1398delC	c.(1396-1398)CCCfs	p.P466fs	KCNK10_uc001xwm.2_Frame_Shift_Del_p.P471fs|KCNK10_uc001xwn.2_Frame_Shift_Del_p.P471fs	NM_021161	NP_066984	P57789	KCNKA_HUMAN	potassium channel, subfamily K, member 10	466	Cytoplasmic (Potential).				signal transduction	integral to membrane	potassium channel activity|voltage-gated ion channel activity			ovary(2)|skin(2)|pancreas(1)	5						GAACGTCCTCGGGCAAGGTCT	0.502			NA											67	121	---	---	---	---	NA	NA	NA	NA	NA
PITPNM3	83394	broad.mit.edu	37	17	6358848	6358848	+	Frame_Shift_Del	DEL	G	G	-			TCGA-64-5774-01A-01D-1625-08	TCGA-64-5774-10A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	df5957d5-20d3-483e-990b-d6369fb990b8	4fb568ce-a4be-46c5-862b-5c681936f30b	g.chr17:6358848delG	uc002gdd.3	-	20	2886	c.2735delC	c.(2734-2736)GCGfs	p.A912fs	PITPNM3_uc010cln.2_Frame_Shift_Del_p.A876fs|PITPNM3_uc010clm.2_Frame_Shift_Del_p.A395fs|PITPNM3_uc002gdc.3_Frame_Shift_Del_p.A503fs	NM_031220	NP_112497	Q9BZ71	PITM3_HUMAN	PITPNM family member 3 isoform 1	912					phosphatidylinositol metabolic process	endomembrane system|integral to membrane	calcium ion binding|lipid binding|phosphatidylinositol transporter activity|receptor tyrosine kinase binding			ovary(2)|central_nervous_system(2)	4				Colorectal(2;0.000372)|READ - Rectum adenocarcinoma(2;0.0276)|LUAD - Lung adenocarcinoma(2;0.0836)|COAD - Colon adenocarcinoma(228;0.185)		CTCTGGCTGCGCGTGCAGCCC	0.692			NA											13	23	---	---	---	---	NA	NA	NA	NA	NA
STK11	6794	broad.mit.edu	37	19	1221313	1221314	+	Frame_Shift_Ins	INS	-	-	C	rs67873004		TCGA-64-5774-01A-01D-1625-08	TCGA-64-5774-10A-01D-1625-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	df5957d5-20d3-483e-990b-d6369fb990b8	4fb568ce-a4be-46c5-862b-5c681936f30b	g.chr19:1221313_1221314insC	uc002lrl.1	+	6	1951_1952	c.836_837insC	c.(835-837)GGCfs	p.G279fs		NM_000455	NP_000446	Q15831	STK11_HUMAN	serine/threonine protein kinase 11	279	Protein kinase.				anoikis|cell cycle arrest|energy reserve metabolic process|insulin receptor signaling pathway|positive regulation of transforming growth factor beta receptor signaling pathway|regulation of fatty acid biosynthetic process|regulation of fatty acid oxidation	cytosol|nucleus	ATP binding|magnesium ion binding|protein serine/threonine kinase activity	p.0?(19)|p.P281fs*6(2)|p.?(2)|p.G279F(1)|p.Y246fs*3(1)		lung(174)|cervix(35)|skin(15)|large_intestine(12)|pancreas(6)|gastrointestinal_tract_(site_indeterminate)(5)|stomach(4)|ovary(4)|breast(2)|upper_aerodigestive_tract(1)|testis(1)|liver(1)|biliary_tract(1)|small_intestine(1)|urinary_tract(1)|oesophagus(1)|prostate(1)|kidney(1)	266		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;7.93e-06)|all_lung(49;1.25e-05)|Breast(49;0.000172)|Renal(1328;0.0183)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|Lung(535;0.00942)|STAD - Stomach adenocarcinoma(1328;0.18)		GGCGACTGTGGCCCCCCGCTCT	0.604			14	D|Mis|N|F|S		NSCLC|pancreatic	jejunal harmartoma|ovarian|testicular|pancreatic			Peutz-Jeghers_syndrome	TSP Lung(3;<1E-08)			6	5	---	---	---	---	NA	NA	NA	NA	NA
CACNA1A	773	broad.mit.edu	37	19	13418663	13418663	+	Frame_Shift_Del	DEL	T	T	-			TCGA-64-5774-01A-01D-1625-08	TCGA-64-5774-10A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	df5957d5-20d3-483e-990b-d6369fb990b8	4fb568ce-a4be-46c5-862b-5c681936f30b	g.chr19:13418663delT	uc010dze.2	-	15	2158	c.1922delA	c.(1921-1923)AATfs	p.N641fs	CACNA1A_uc010dzc.2_Frame_Shift_Del_p.N166fs|CACNA1A_uc002mwy.3_Frame_Shift_Del_p.N640fs|CACNA1A_uc010xne.1_Frame_Shift_Del_p.N166fs	NM_001127221	NP_001120693	O00555	CAC1A_HUMAN	calcium channel, alpha 1A subunit isoform 3	641	Extracellular (Potential).|II.				cell death|elevation of cytosolic calcium ion concentration|energy reserve metabolic process|membrane depolarization|regulation of insulin secretion	cytoplasm|nucleus	syntaxin binding			large_intestine(2)	2			OV - Ovarian serous cystadenocarcinoma(19;5.07e-21)		Bepridil(DB01244)|Cinnarizine(DB00568)|Loperamide(DB00836)|Nisoldipine(DB00401)|Pregabalin(DB00230)	TTCATCGAAATTAAACCTGCA	0.547			NA											55	14	---	---	---	---	NA	NA	NA	NA	NA
ZNF671	79891	broad.mit.edu	37	19	58232780	58232780	+	Frame_Shift_Del	DEL	C	C	-			TCGA-64-5774-01A-01D-1625-08	TCGA-64-5774-10A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	df5957d5-20d3-483e-990b-d6369fb990b8	4fb568ce-a4be-46c5-862b-5c681936f30b	g.chr19:58232780delC	uc002qpz.3	-	4	773	c.674delG	c.(673-675)GGCfs	p.G225fs	ZNF776_uc002qpx.2_Intron|ZNF671_uc010eug.2_Frame_Shift_Del_p.G148fs|ZNF671_uc010yhf.1_Frame_Shift_Del_p.G127fs	NM_024833	NP_079109	Q8TAW3	ZN671_HUMAN	zinc finger protein 671	225					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Colorectal(82;0.000256)|all_neural(62;0.0577)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0257)		AGAGTCTCTGCCCTCCTTCCT	0.507			NA											9	74	---	---	---	---	NA	NA	NA	NA	NA
DEFB115	245929	broad.mit.edu	37	20	29847303	29847304	+	Frame_Shift_Ins	INS	-	-	A			TCGA-64-5774-01A-01D-1625-08	TCGA-64-5774-10A-01D-1625-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	df5957d5-20d3-483e-990b-d6369fb990b8	4fb568ce-a4be-46c5-862b-5c681936f30b	g.chr20:29847303_29847304insA	uc002wvp.1	+	2	135_136	c.135_136insA	c.(133-138)TGCAGGfs	p.C45fs		NM_001037730	NP_001032819	Q30KQ5	DB115_HUMAN	beta-defensin 115 precursor	45_46					defense response to bacterium	extracellular region				ovary(1)	1			Colorectal(19;0.00445)|COAD - Colon adenocarcinoma(19;0.0347)			CTGGCAGATGCAGGAAATCATG	0.317			NA											21	30	---	---	---	---	NA	NA	NA	NA	NA
RBPJ	3516	broad.mit.edu	37	4	26417145	26417146	+	Frame_Shift_Ins	INS	-	-	A			TCGA-64-5774-01A-01D-1625-08	TCGA-64-5774-10A-01D-1625-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	df5957d5-20d3-483e-990b-d6369fb990b8	4fb568ce-a4be-46c5-862b-5c681936f30b	g.chr4:26417145_26417146insA	uc003grx.1	+	5	479_480	c.243_244insA	c.(241-246)AAGAAAfs	p.K81fs	RBPJ_uc003gry.1_Frame_Shift_Ins_p.K66fs|RBPJ_uc003grz.1_Frame_Shift_Ins_p.K81fs|RBPJ_uc011bxt.1_Frame_Shift_Ins_p.K81fs|RBPJ_uc003gsa.1_Frame_Shift_Ins_p.K67fs|RBPJ_uc003gsb.1_Frame_Shift_Ins_p.K68fs|RBPJ_uc003gsc.1_Frame_Shift_Ins_p.K67fs	NM_005349	NP_005340	Q06330	SUH_HUMAN	recombining binding protein suppressor of	81_82					DNA recombination|negative regulation of transcription, DNA-dependent|positive regulation of transcription of Notch receptor target	cytoplasm|nucleolus|nucleoplasm	DNA binding|protein binding|recombinase activity|sequence-specific DNA binding transcription factor activity			ovary(1)|lung(1)|central_nervous_system(1)	3		Breast(46;0.0503)				GTGGATGGAAGAAAAAAAAAGA	0.371			NA											7	290	---	---	---	---	NA	NA	NA	NA	NA
C4orf41	60684	broad.mit.edu	37	4	184605873	184605874	+	Frame_Shift_Ins	INS	-	-	TATC			TCGA-64-5774-01A-01D-1625-08	TCGA-64-5774-10A-01D-1625-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	df5957d5-20d3-483e-990b-d6369fb990b8	4fb568ce-a4be-46c5-862b-5c681936f30b	g.chr4:184605873_184605874insTATC	uc003ivx.2	+	15	1622_1623	c.1446_1447insTATC	c.(1444-1449)GATTATfs	p.D482fs	C4orf41_uc003ivw.2_Frame_Shift_Ins_p.D482fs|C4orf41_uc010isc.2_Intron|C4orf41_uc003ivy.2_Frame_Shift_Ins_p.D88fs	NM_021942	NP_068761	Q7Z392	CD041_HUMAN	hypothetical protein LOC60684 isoform a	482_483											0		all_lung(41;4.4e-14)|Lung NSC(41;1.03e-13)|Colorectal(36;0.00139)|all_hematologic(60;0.00756)|Hepatocellular(41;0.00826)|Renal(120;0.00988)|Prostate(90;0.0235)|all_neural(102;0.202)		all cancers(43;1.39e-26)|Epithelial(43;2.42e-22)|OV - Ovarian serous cystadenocarcinoma(60;6.85e-10)|GBM - Glioblastoma multiforme(59;6.71e-06)|Colorectal(24;9.67e-06)|STAD - Stomach adenocarcinoma(60;2.36e-05)|COAD - Colon adenocarcinoma(29;7.07e-05)|LUSC - Lung squamous cell carcinoma(40;0.00984)|READ - Rectum adenocarcinoma(43;0.171)		TGATGTGTGATTATCGGAGTGA	0.406			NA											15	101	---	---	---	---	NA	NA	NA	NA	NA