Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	ACHILLES_Top_Genes	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
SCNN1D	6339	broad.mit.edu	37	1	1222975	1222975	+	Missense_Mutation	SNP	C	C	G	rs147342518		TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr1:1222975C>G	uc001adu.1	+	9	1530	c.906C>G	c.(904-906)CAC>CAG	p.H302Q	SCNN1D_uc001adt.1_Missense_Mutation_p.H466Q|SCNN1D_uc001adw.2_Missense_Mutation_p.H368Q|SCNN1D_uc001adx.2_Missense_Mutation_p.T66R|SCNN1D_uc001adv.2_Missense_Mutation_p.H302Q	NM_002978	NP_002969			sodium channel, nonvoltage-gated 1, delta												0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;3.01e-35)|OV - Ovarian serous cystadenocarcinoma(86;2.46e-21)|Colorectal(212;0.000157)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00229)|BRCA - Breast invasive adenocarcinoma(365;0.00251)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.034)|Lung(427;0.199)		GCATCACCCACGGTGGGTGCC	0.682			NA											12	29					0	0	0.000978	0	0
KIAA1751	85452	broad.mit.edu	37	1	1902213	1902213	+	Nonsense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr1:1902213C>A	uc001aim.1	-	10	1087	c.931G>T	c.(931-933)GAG>TAG	p.E311*	KIAA1751_uc009vkz.1_Nonsense_Mutation_p.E311*	NM_001080484	NP_001073953	Q9C0B2	K1751_HUMAN	hypothetical protein LOC85452	311	Potential.									pancreas(1)	1	all_cancers(77;0.000708)|all_epithelial(69;0.000943)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;6.04e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Medulloblastoma(700;0.151)|Lung SC(97;0.217)		Epithelial(90;8.79e-39)|OV - Ovarian serous cystadenocarcinoma(86;9.61e-25)|GBM - Glioblastoma multiforme(42;1.2e-07)|Colorectal(212;4.84e-05)|COAD - Colon adenocarcinoma(227;0.000214)|Kidney(185;0.00254)|BRCA - Breast invasive adenocarcinoma(365;0.00461)|STAD - Stomach adenocarcinoma(132;0.00645)|KIRC - Kidney renal clear cell carcinoma(229;0.037)|Lung(427;0.205)		TCCGCCAGCTCTGCCTTGGCA	0.627			NA											11	40					2.27111e-07	2.85232e-07	0.001368	1	0
PRDM16	63976	broad.mit.edu	37	1	3328730	3328730	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr1:3328730G>T	uc001akf.2	+	9	2049	c.1969G>T	c.(1969-1971)GGG>TGG	p.G657W	PRDM16_uc001akc.2_Missense_Mutation_p.G657W|PRDM16_uc001akd.2_Missense_Mutation_p.G657W|PRDM16_uc001ake.2_Missense_Mutation_p.G657W|PRDM16_uc009vlh.2_Missense_Mutation_p.G358W	NM_022114	NP_071397	Q9HAZ2	PRD16_HUMAN	PR domain containing 16 isoform 1	657					brown fat cell differentiation|negative regulation of granulocyte differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transforming growth factor beta receptor signaling pathway|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|regulation of cellular respiration|transcription, DNA-dependent	transcriptional repressor complex	protein binding|sequence-specific DNA binding|transcription coactivator activity|zinc ion binding			lung(3)|ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	7	all_cancers(77;0.00208)|all_epithelial(69;0.000732)|Ovarian(185;0.0634)|Lung NSC(156;0.109)|all_lung(157;0.111)	all_epithelial(116;2.03e-21)|all_lung(118;7.55e-09)|Lung NSC(185;1.28e-06)|Breast(487;0.000792)|Renal(390;0.00137)|Hepatocellular(190;0.00515)|Myeloproliferative disorder(586;0.0267)|Ovarian(437;0.0365)|Lung SC(97;0.114)|Medulloblastoma(700;0.134)		Epithelial(90;5.59e-35)|OV - Ovarian serous cystadenocarcinoma(86;1.99e-20)|GBM - Glioblastoma multiforme(42;3.72e-11)|Colorectal(212;0.000425)|BRCA - Breast invasive adenocarcinoma(365;0.000946)|COAD - Colon adenocarcinoma(227;0.000968)|Kidney(185;0.00155)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0175)|Lung(427;0.137)		GGCGCCCCCGGGGGCCCCGAA	0.692			NA	T	EVI1	MDS|AML								12	20					5.50884e-06	6.54807e-06	0.001368	1	0
DFFB	1677	broad.mit.edu	37	1	3775365	3775365	+	Silent	SNP	C	C	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr1:3775365C>T	uc001alc.2	+	2	521	c.198C>T	c.(196-198)AAC>AAT	p.N66N	DFFB_uc001ale.2_RNA|DFFB_uc009vlp.2_RNA|DFFB_uc001alb.2_RNA|DFFB_uc010nzn.1_Silent_p.N66N|DFFB_uc009vlq.2_RNA|DFFB_uc009vlr.2_Translation_Start_Site|DFFB_uc001ald.2_Translation_Start_Site|KIAA0562_uc001aky.2_5'Flank|KIAA0562_uc010nzm.1_5'Flank|KIAA0562_uc001akz.2_5'Flank|DFFB_uc009vln.1_Silent_p.N66N|DFFB_uc001ala.1_Silent_p.N66N|DFFB_uc009vlo.1_Silent_p.N66N	NM_004402	NP_004393	O76075	DFFB_HUMAN	DNA fragmentation factor, 40 kD, beta	66	CIDE-N.				apoptotic chromosome condensation|DNA fragmentation involved in apoptotic nuclear change|intracellular signal transduction	cytosol|nucleoplasm	deoxyribonuclease activity|enzyme binding				0	all_cancers(77;0.0395)|Ovarian(185;0.0634)|all_lung(157;0.222)|Lung NSC(156;0.227)	all_cancers(23;2.05e-30)|all_epithelial(116;6.22e-21)|all_lung(118;2.65e-08)|Lung NSC(185;6.25e-06)|Breast(487;0.000659)|Renal(390;0.00121)|all_neural(13;0.0019)|Hepatocellular(190;0.00705)|Colorectal(325;0.0113)|all_hematologic(16;0.0194)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0308)|Lung SC(97;0.0548)|Medulloblastoma(700;0.211)		Epithelial(90;1.18e-39)|OV - Ovarian serous cystadenocarcinoma(86;7.28e-23)|GBM - Glioblastoma multiforme(42;2.95e-17)|Colorectal(212;1.23e-05)|COAD - Colon adenocarcinoma(227;5.94e-05)|Kidney(185;0.000371)|BRCA - Breast invasive adenocarcinoma(365;0.00038)|KIRC - Kidney renal clear cell carcinoma(229;0.00571)|STAD - Stomach adenocarcinoma(132;0.00645)|Lung(427;0.124)		TTCCCGACAACGCCGAGCTGG	0.652			NA											4	41					0	0	0.000602	0	0
ACOT7	11332	broad.mit.edu	37	1	6341241	6341241	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr1:6341241C>G	uc001ams.2	-	8	1122	c.965G>C	c.(964-966)CGC>CCC	p.R322P	ACOT7_uc010nzq.1_Missense_Mutation_p.R207P|ACOT7_uc001amt.2_Missense_Mutation_p.R312P|ACOT7_uc001amu.2_RNA|ACOT7_uc001amv.2_RNA|ACOT7_uc001amq.2_Missense_Mutation_p.R271P|ACOT7_uc001amr.2_Missense_Mutation_p.R292P	NM_181864	NP_863654	O00154	BACH_HUMAN	acyl-CoA thioesterase 7 isoform hBACHb	322						mitochondrion|nucleus	carboxylesterase activity|fatty-acyl-CoA binding|palmitoyl-CoA hydrolase activity				0	Ovarian(185;0.0634)|all_lung(157;0.175)	all_cancers(23;1.42e-38)|all_epithelial(116;3.96e-23)|all_lung(118;3.69e-08)|Lung NSC(185;8.52e-07)|all_hematologic(16;6.92e-06)|Colorectal(325;4.53e-05)|Acute lymphoblastic leukemia(12;5e-05)|all_neural(13;0.000164)|Breast(487;0.000688)|Renal(390;0.0007)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0393)|Medulloblastoma(700;0.211)		Epithelial(90;9.16e-37)|GBM - Glioblastoma multiforme(13;5.89e-29)|OV - Ovarian serous cystadenocarcinoma(86;7.63e-19)|Colorectal(212;1.27e-07)|COAD - Colon adenocarcinoma(227;2.06e-05)|Kidney(185;7.74e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.00129)|BRCA - Breast invasive adenocarcinoma(365;0.00132)|STAD - Stomach adenocarcinoma(132;0.00195)|READ - Rectum adenocarcinoma(331;0.0481)		GGCCCGGTAGCGCTTCTGAGA	0.607	GBM(74;673 1226 4974 11850 13190)		NA									OREG0013034	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	11	35					0	0	0.000978	0	0
TAS1R1	80835	broad.mit.edu	37	1	6631250	6631250	+	Missense_Mutation	SNP	T	T	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr1:6631250T>A	uc001ant.2	+	2	473	c.473T>A	c.(472-474)CTG>CAG	p.L158Q	TAS1R1_uc001anu.2_Missense_Mutation_p.L158Q|TAS1R1_uc001anv.2_Missense_Mutation_p.L158Q|TAS1R1_uc001anw.2_Missense_Mutation_p.L158Q	NM_138697	NP_619642	Q7RTX1	TS1R1_HUMAN	sweet taste receptor T1r isoform b	158	Extracellular (Potential).				sensory perception of umami taste	plasma membrane	protein heterodimerization activity|taste receptor activity			ovary(1)|central_nervous_system(1)|skin(1)	3	Ovarian(185;0.0212)|all_lung(157;0.154)	all_cancers(23;8.73e-34)|all_epithelial(116;9.26e-22)|all_lung(118;7.57e-07)|Lung NSC(185;4.26e-06)|Breast(487;0.000353)|Renal(390;0.0007)|Colorectal(325;0.00104)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0443)		Colorectal(212;1.29e-07)|COAD - Colon adenocarcinoma(227;1.33e-05)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000896)|BRCA - Breast invasive adenocarcinoma(365;0.00108)|STAD - Stomach adenocarcinoma(132;0.0167)|READ - Rectum adenocarcinoma(331;0.0642)		ACAGCCGCCCTGCTGAGCCCT	0.607			NA											17	44					0	0	0.008871	0	0
DNAJC11	55735	broad.mit.edu	37	1	6704656	6704656	+	Silent	SNP	G	G	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr1:6704656G>A	uc001aof.2	-	10	1165	c.1059C>T	c.(1057-1059)GTC>GTT	p.V353V	DNAJC11_uc010nzt.1_Intron|DNAJC11_uc001aog.2_Silent_p.V353V|DNAJC11_uc010nzu.1_Silent_p.V263V	NM_018198	NP_060668	Q9NVH1	DJC11_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 11	353					protein folding		heat shock protein binding|unfolded protein binding			ovary(1)|skin(1)	2	Ovarian(185;0.0265)|all_lung(157;0.154)	all_cancers(23;1.97e-27)|all_epithelial(116;1.76e-17)|all_lung(118;2.27e-05)|Lung NSC(185;9.97e-05)|Renal(390;0.00188)|Breast(487;0.00289)|Colorectal(325;0.00342)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.156)		Colorectal(212;2.34e-07)|COAD - Colon adenocarcinoma(227;2.05e-05)|Kidney(185;7.67e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000639)|KIRC - Kidney renal clear cell carcinoma(229;0.00128)|STAD - Stomach adenocarcinoma(132;0.00179)|READ - Rectum adenocarcinoma(331;0.0649)		CTCCAACGCTGACAGCTGCAC	0.537			NA											9	25					0	0	0.004482	0	0
EXOSC10	5394	broad.mit.edu	37	1	11141175	11141175	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr1:11141175C>G	uc001asa.2	-	11	1451	c.1401G>C	c.(1399-1401)CAG>CAC	p.Q467H	EXOSC10_uc001asb.2_Missense_Mutation_p.Q467H|EXOSC10_uc009vmy.1_Missense_Mutation_p.Q467H	NM_001001998	NP_001001998	Q01780	EXOSX_HUMAN	exosome component 10 isoform 1	467					CUT catabolic process|histone mRNA catabolic process|maturation of 5.8S rRNA|nuclear polyadenylation-dependent rRNA catabolic process|nuclear retention of unspliced pre-mRNA at the site of transcription|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	cytoplasm|nuclear exosome (RNase complex)|nucleolus|transcriptionally active chromatin	3'-5' exonuclease activity|exoribonuclease activity|identical protein binding|nucleotide binding|protein serine/threonine kinase activity|RNA binding			upper_aerodigestive_tract(1)	1	Ovarian(185;0.249)	Lung NSC(185;1.74e-05)|all_lung(284;2.05e-05)|Renal(390;0.000147)|Colorectal(325;0.00205)|Breast(348;0.00262)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;4.18e-07)|COAD - Colon adenocarcinoma(227;8.33e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000315)|Kidney(185;0.000832)|KIRC - Kidney renal clear cell carcinoma(229;0.00269)|READ - Rectum adenocarcinoma(331;0.0526)|STAD - Stomach adenocarcinoma(313;0.202)		GCCACACCACCTGCAGCTGCA	0.587	Colon(179;105 1987 14326 27364 29542)		NA											3	27					0	0	0.009096	0	0
MAD2L2	10459	broad.mit.edu	37	1	11736107	11736107	+	Silent	SNP	G	G	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr1:11736107G>A	uc001asp.2	-	6	611	c.423C>T	c.(421-423)CCC>CCT	p.P141P	MAD2L2_uc009vnc.2_Silent_p.P141P|MAD2L2_uc001asq.3_Silent_p.P141P	NM_006341	NP_006332	Q9UI95	MD2L2_HUMAN	MAD2 homolog	141	Mediates interaction with REV1 and REV3L and homodimerization.|HORMA.				cell division|DNA damage response, signal transduction resulting in transcription|double-strand break repair|mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of mitotic anaphase-promoting complex activity|positive regulation of peptidyl-serine phosphorylation|positive regulation of transcription, DNA-dependent|regulation of cell growth|transcription, DNA-dependent	cytoplasm|nucleoplasm|spindle|zeta DNA polymerase complex	JUN kinase binding				0	Ovarian(185;0.249)	Lung NSC(185;4.15e-05)|all_lung(284;4.76e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;5.04e-06)|COAD - Colon adenocarcinoma(227;0.000245)|BRCA - Breast invasive adenocarcinoma(304;0.000295)|Kidney(185;0.000733)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		ACACACCTGGGGGGTTGTGGT	0.577			NA						DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage					16	34					0	0	0.010504	0	0
SPEN	23013	broad.mit.edu	37	1	16255538	16255538	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr1:16255538G>T	uc001axk.1	+	11	3007	c.2803G>T	c.(2803-2805)GTT>TTT	p.V935F	SPEN_uc010obp.1_Missense_Mutation_p.V894F	NM_015001	NP_055816	Q96T58	MINT_HUMAN	spen homolog, transcriptional regulator	935					interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|Notch signaling pathway	nucleus	nucleotide binding|protein binding|RNA binding			ovary(6)|breast(3)|lung(2)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	15		Colorectal(325;0.000258)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0185)|Colorectal(212;5.96e-07)|COAD - Colon adenocarcinoma(227;3.11e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000115)|Kidney(64;0.000212)|KIRC - Kidney renal clear cell carcinoma(64;0.003)|STAD - Stomach adenocarcinoma(313;0.013)|READ - Rectum adenocarcinoma(331;0.0681)		ACTGGAATCAGTTAGAATGAA	0.468			NA											20	103					1.50039e-11	2.15148e-11	0.001882	1	0
FBXO42	54455	broad.mit.edu	37	1	16578015	16578015	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr1:16578015C>T	uc001ayg.2	-	10	1520	c.1304G>A	c.(1303-1305)GGC>GAC	p.G435D	FBXO42_uc001aye.3_Missense_Mutation_p.G153D|FBXO42_uc001ayf.2_Missense_Mutation_p.G342D	NM_018994	NP_061867	Q6P3S6	FBX42_HUMAN	F-box protein 42	435										upper_aerodigestive_tract(1)|skin(1)	2		Colorectal(325;0.000147)|Renal(390;0.00145)|Breast(348;0.00224)|Lung NSC(340;0.00475)|all_lung(284;0.00671)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0646)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0193)|Colorectal(212;3.16e-07)|COAD - Colon adenocarcinoma(227;1.46e-05)|BRCA - Breast invasive adenocarcinoma(304;4.37e-05)|Kidney(64;0.000246)|KIRC - Kidney renal clear cell carcinoma(64;0.00336)|STAD - Stomach adenocarcinoma(313;0.0139)|READ - Rectum adenocarcinoma(331;0.0693)		GATAGGAGAGCCGTCTCCTCT	0.577			NA											4	9					0	0	0.000602	0	0
ESPNP	284729	broad.mit.edu	37	1	17017716	17017716	+	Missense_Mutation	SNP	T	T	C			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr1:17017716T>C	uc001azn.1	-	11	2012	c.1898A>G	c.(1897-1899)GAG>GGG	p.E633G		NR_026567				RecName: Full=Espin; AltName: Full=Ectoplasmic specialization protein; AltName: Full=Autosomal recessive deafness type 36 protein;												0						GGCTCACCTCTCTTCTTCCAG	0.622			NA											5	30					0	0	0.000602	0	0
ACTL8	81569	broad.mit.edu	37	1	18149614	18149614	+	Silent	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr1:18149614G>T	uc001bat.2	+	2	327	c.111G>T	c.(109-111)CCG>CCT	p.P37P		NM_030812	NP_110439	Q9H568	ACTL8_HUMAN	actin-like 8	37						cytoplasm|cytoskeleton				ovary(4)	4		Colorectal(325;0.000147)|Renal(390;0.00145)|Breast(348;0.00186)|all_lung(284;0.0054)|Lung NSC(340;0.00566)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0439)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00583)|BRCA - Breast invasive adenocarcinoma(304;6.43e-06)|Kidney(64;0.000258)|KIRC - Kidney renal clear cell carcinoma(64;0.00348)|STAD - Stomach adenocarcinoma(196;0.00652)|READ - Rectum adenocarcinoma(331;0.0698)|Lung(427;0.201)		ACTACCTACCGTGCAAGGAGA	0.587			NA											17	45					1.56452e-12	2.31028e-12	0.007413	1	0
EIF4G3	8672	broad.mit.edu	37	1	21220017	21220017	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr1:21220017C>A	uc001bec.2	-	13	2334	c.2078G>T	c.(2077-2079)GGC>GTC	p.G693V	EIF4G3_uc010odi.1_Missense_Mutation_p.G297V|EIF4G3_uc010odj.1_Missense_Mutation_p.G692V|EIF4G3_uc009vpz.2_Missense_Mutation_p.G413V|EIF4G3_uc001bed.2_Missense_Mutation_p.G693V|EIF4G3_uc001bef.2_Missense_Mutation_p.G692V|EIF4G3_uc001bee.2_Missense_Mutation_p.G699V	NM_003760	NP_003751	O43432	IF4G3_HUMAN	eukaryotic translation initiation factor 4	693					interspecies interaction between organisms|regulation of translational initiation|RNA metabolic process	eukaryotic translation initiation factor 4F complex	protein binding|RNA cap binding|translation initiation factor activity			skin(1)	1		all_lung(284;2.61e-06)|Lung NSC(340;2.81e-06)|Colorectal(325;3.46e-05)|Renal(390;9.67e-05)|Breast(348;0.00149)|Ovarian(437;0.00338)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.023)|COAD - Colon adenocarcinoma(152;5.42e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000327)|GBM - Glioblastoma multiforme(114;0.000696)|Kidney(64;0.0018)|STAD - Stomach adenocarcinoma(196;0.00644)|KIRC - Kidney renal clear cell carcinoma(64;0.0185)|READ - Rectum adenocarcinoma(331;0.124)|Lung(427;0.191)		TACAGGTACGCCTCTTCCACC	0.473			NA											11	37					0.000151284	0.000170553	0.001855	1	0
HSPG2	3339	broad.mit.edu	37	1	22172956	22172956	+	Silent	SNP	G	G	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr1:22172956G>A	uc001bfj.2	-	63	8341	c.8301C>T	c.(8299-8301)CTC>CTT	p.L2767L	HSPG2_uc009vqd.2_Silent_p.L2768L	NM_005529	NP_005520	P98160	PGBM_HUMAN	heparan sulfate proteoglycan 2 precursor	2767	Ig-like C2-type 13.				angiogenesis|cell adhesion|lipid metabolic process|lipoprotein metabolic process	basement membrane|extracellular space|plasma membrane	protein C-terminus binding			ovary(5)|large_intestine(2)|central_nervous_system(1)|skin(1)	9		Colorectal(325;3.46e-05)|all_lung(284;7.93e-05)|Lung NSC(340;8.71e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0498)|OV - Ovarian serous cystadenocarcinoma(117;1.14e-26)|Colorectal(126;4.18e-07)|COAD - Colon adenocarcinoma(152;1.82e-05)|GBM - Glioblastoma multiforme(114;3.13e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000756)|STAD - Stomach adenocarcinoma(196;0.00656)|KIRC - Kidney renal clear cell carcinoma(1967;0.00942)|READ - Rectum adenocarcinoma(331;0.0721)|Lung(427;0.223)	Becaplermin(DB00102)|Palifermin(DB00039)	GGTGACTGGGGAGGCTGCCCC	0.657			NA											15	71					0	0	0.00499	0	0
ZBTB40	9923	broad.mit.edu	37	1	22850841	22850841	+	Silent	SNP	C	C	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr1:22850841C>T	uc001bft.2	+	18	3940	c.3429C>T	c.(3427-3429)CTC>CTT	p.L1143L	ZBTB40_uc001bfu.2_Silent_p.L1143L|ZBTB40_uc009vqi.1_Silent_p.L1031L	NM_001083621	NP_001077090	Q9NUA8	ZBT40_HUMAN	zinc finger and BTB domain containing 40	1143	C2H2-type 12.				bone mineralization|regulation of transcription, DNA-dependent|response to DNA damage stimulus|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Colorectal(325;3.46e-05)|Lung NSC(340;6.55e-05)|all_lung(284;9.87e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;2.86e-26)|Colorectal(126;8.55e-08)|COAD - Colon adenocarcinoma(152;4.1e-06)|GBM - Glioblastoma multiforme(114;1.39e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000712)|KIRC - Kidney renal clear cell carcinoma(1967;0.00374)|STAD - Stomach adenocarcinoma(196;0.00645)|READ - Rectum adenocarcinoma(331;0.0693)|Lung(427;0.216)		GTGGGGAACTCTTCACCTCCC	0.577			NA											11	31					0	0	0.001368	0	0
EPHA8	2046	broad.mit.edu	37	1	22927454	22927454	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr1:22927454C>A	uc001bfx.1	+	15	2727	c.2602C>A	c.(2602-2604)CAC>AAC	p.H868N		NM_020526	NP_065387	P29322	EPHA8_HUMAN	ephrin receptor EphA8 isoform 1 precursor	868	Cytoplasmic (Potential).|Protein kinase.					integral to plasma membrane	ATP binding|ephrin receptor activity			central_nervous_system(5)|breast(3)|lung(2)|large_intestine(1)|stomach(1)|skin(1)	13		Colorectal(325;3.46e-05)|Lung NSC(340;6.55e-05)|all_lung(284;9.87e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;7.29e-27)|Colorectal(126;1.61e-07)|COAD - Colon adenocarcinoma(152;1.14e-05)|GBM - Glioblastoma multiforme(114;1.74e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000554)|KIRC - Kidney renal clear cell carcinoma(1967;0.00272)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.199)		CCACGCCCTGCACCAGCTCAT	0.677			NA											24	52					1.50538e-07	1.90511e-07	0.00632	1	0
EPHA8	2046	broad.mit.edu	37	1	22927967	22927967	+	Splice_Site	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr1:22927967G>T	uc001bfx.1	+	16	3028	c.2903_splice	c.e16+1	p.Q968_splice		NM_020526	NP_065387	P29322	EPHA8_HUMAN	ephrin receptor EphA8 isoform 1 precursor							integral to plasma membrane	ATP binding|ephrin receptor activity			central_nervous_system(5)|breast(3)|lung(2)|large_intestine(1)|stomach(1)|skin(1)	13		Colorectal(325;3.46e-05)|Lung NSC(340;6.55e-05)|all_lung(284;9.87e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;7.29e-27)|Colorectal(126;1.61e-07)|COAD - Colon adenocarcinoma(152;1.14e-05)|GBM - Glioblastoma multiforme(114;1.74e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000554)|KIRC - Kidney renal clear cell carcinoma(1967;0.00272)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.199)		TGAACGCCCAGTGAGTGATGG	0.692			NA											11	21					9.70103e-10	1.33322e-09	0.008291	1	0
C1QB	713	broad.mit.edu	37	1	22987523	22987523	+	Missense_Mutation	SNP	C	C	T	rs149072794	byFrequency	TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr1:22987523C>T	uc001bgd.2	+	3	538	c.406C>T	c.(406-408)CGG>TGG	p.R136W		NM_000491	NP_000482	P02746	C1QB_HUMAN	complement component 1, q subcomponent, B chain	136	C1q.				complement activation, classical pathway|innate immune response	collagen|complement component C1 complex				breast(1)	1		Colorectal(325;3.46e-05)|Lung NSC(340;6.55e-05)|all_lung(284;9.87e-05)|Renal(390;0.000219)|Breast(348;0.00262)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;7.06e-27)|Colorectal(126;1.58e-07)|GBM - Glioblastoma multiforme(114;6.72e-06)|COAD - Colon adenocarcinoma(152;1.13e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000551)|KIRC - Kidney renal clear cell carcinoma(1967;0.0027)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.198)	Abciximab(DB00054)|Adalimumab(DB00051)|Alefacept(DB00092)|Alemtuzumab(DB00087)|Basiliximab(DB00074)|Bevacizumab(DB00112)|Cetuximab(DB00002)|Daclizumab(DB00111)|Efalizumab(DB00095)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Natalizumab(DB00108)|Palivizumab(DB00110)|Rituximab(DB00073)|Tositumomab(DB00081)|Trastuzumab(DB00072)	CCCCCTGCGCCGGGACCAGAC	0.587			NA											13	85					0	0	0.004007	0	0
RPA2	6118	broad.mit.edu	37	1	28223634	28223634	+	Splice_Site	SNP	T	T	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr1:28223634T>A	uc001bpe.1	-	6	691	c.409_splice	c.e6-1	p.N137_splice	RPA2_uc001bpd.1_Splice_Site_p.N145_splice|RPA2_uc010ofp.1_Splice_Site_p.N41_splice	NM_002946	NP_002937	P15927	RFA2_HUMAN	replication protein A2, 32kDa						cell cycle checkpoint|DNA recombinase assembly|DNA strand elongation involved in DNA replication|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|nucleotide-excision repair, DNA damage removal|nucleotide-excision repair, DNA gap filling|regulation of double-strand break repair via homologous recombination|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	DNA replication factor A complex|PML body	protein phosphatase binding|single-stranded DNA binding			skin(1)	1		Colorectal(325;0.000147)|Renal(390;0.00357)|Lung NSC(340;0.00588)|all_lung(284;0.00645)|Breast(348;0.0174)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0545)|all_neural(195;0.0557)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0429)|OV - Ovarian serous cystadenocarcinoma(117;3.62e-24)|Colorectal(126;3.23e-08)|COAD - Colon adenocarcinoma(152;1.75e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.00294)|STAD - Stomach adenocarcinoma(196;0.00308)|BRCA - Breast invasive adenocarcinoma(304;0.00613)|READ - Rectum adenocarcinoma(331;0.0649)		CTTTTTGTTCTATTAAAATGA	0.343			NA						Direct_reversal_of_damage|NER					4	15					0	0	0.009096	0	0
SMPDL3B	27293	broad.mit.edu	37	1	28275671	28275671	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr1:28275671C>T	uc001bpg.2	+	3	562	c.371C>T	c.(370-372)CCA>CTA	p.P124L	SMPDL3B_uc001bpf.2_Missense_Mutation_p.P124L|SMPDL3B_uc010ofq.1_5'UTR|SMPDL3B_uc010ofr.1_Missense_Mutation_p.P124L	NM_014474	NP_055289	Q92485	ASM3B_HUMAN	acid sphingomyelinase-like phosphodiesterase 3B	124					sphingomyelin catabolic process	extracellular space	hydrolase activity, acting on glycosyl bonds|sphingomyelin phosphodiesterase activity			ovary(3)	3		Colorectal(325;3.46e-05)|all_lung(284;0.000414)|Lung NSC(340;0.000431)|Renal(390;0.00121)|Breast(348;0.00345)|Ovarian(437;0.00503)|all_neural(195;0.0208)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0419)|OV - Ovarian serous cystadenocarcinoma(117;5.68e-24)|Colorectal(126;1.65e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.00273)|STAD - Stomach adenocarcinoma(196;0.00303)|BRCA - Breast invasive adenocarcinoma(304;0.00587)|READ - Rectum adenocarcinoma(331;0.055)		GAGGTCTTTCCAGGTAAGACT	0.552			NA											12	21					0	0	0.000978	0	0
DCDC2B	149069	broad.mit.edu	37	1	32680429	32680429	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr1:32680429C>A	uc001bun.2	+	7	746	c.746C>A	c.(745-747)CCC>CAC	p.P249H	C1orf91_uc001buo.3_RNA|C1orf91_uc001bup.3_RNA	NM_001099434	NP_001092904	A2VCK2	DCD2B_HUMAN	doublecortin domain containing 2B	249					intracellular signal transduction						0		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Ovarian(437;0.101)|Breast(348;0.174)				GTAACCCAGCCCTCTCCAAAG	0.557			NA											9	39					0.000274275	0.000304364	0.004482	1	0
CSMD2	114784	broad.mit.edu	37	1	34498244	34498244	+	Silent	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr1:34498244G>T	uc001bxn.1	-	3	377	c.348C>A	c.(346-348)CTC>CTA	p.L116L	CSMD2_uc001bxm.1_Silent_p.L156L	NM_052896	NP_443128	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	116	CUB 1.|Extracellular (Potential).					integral to membrane|plasma membrane	protein binding			ovary(6)|skin(5)|pancreas(1)	12		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				AGTCGCTGATGAGGCGCAGAG	0.547			NA											4	5					5.9392e-07	7.35353e-07	0.001168	1	0
MTF1	4520	broad.mit.edu	37	1	38305733	38305733	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr1:38305733G>A	uc001cce.1	-	3	647	c.506C>T	c.(505-507)ACC>ATC	p.T169I	MTF1_uc009vvj.1_5'UTR	NM_005955	NP_005946	Q14872	MTF1_HUMAN	metal-regulatory transcription factor 1	169						nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|zinc ion binding			ovary(1)|pancreas(1)	2	Acute lymphoblastic leukemia(166;0.074)|all_hematologic(146;0.197)	Myeloproliferative disorder(586;0.0255)				ACAGACAAAGGTGTACTCTCC	0.547			NA											23	56					0	0	0.007291	0	0
MACF1	23499	broad.mit.edu	37	1	39781279	39781279	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr1:39781279G>T	uc010ois.1	+	28	3585	c.3380G>T	c.(3379-3381)AGT>ATT	p.S1127I	MACF1_uc001cda.1_Missense_Mutation_p.S1035I|MACF1_uc001cdc.1_Missense_Mutation_p.S214I|MACF1_uc009vvq.1_Missense_Mutation_p.S184I|MACF1_uc001cdb.1_Missense_Mutation_p.S214I	NM_012090	NP_036222	Q9UPN3	MACF1_HUMAN	microfilament and actin filament cross-linker	1127	Poly-Ser.				cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			ovary(8)|breast(3)|central_nervous_system(3)|skin(2)	16	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			TCTAGTTCAAGTGTCCCAACT	0.463			NA											28	35					3.1745e-13	4.74897e-13	0.008361	1	0
SMAP2	64744	broad.mit.edu	37	1	40882506	40882507	+	Missense_Mutation	DNP	CC	CC	TT			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr1:40882506_40882507CC>TT	uc001cfj.2	+	9	967_968	c.902_903CC>TT	c.(901-903)CCC>CTT	p.P301L	SMAP2_uc001cfk.2_Missense_Mutation_p.P271L|SMAP2_uc010oji.1_Missense_Mutation_p.P218L|SMAP2_uc010ojj.1_Missense_Mutation_p.P117L	NM_022733	NP_073570	Q8WU79	SMAP2_HUMAN	small ArfGAP2	301	Met-rich.				regulation of ARF GTPase activity	cytoplasm|nucleus	ARF GTPase activator activity|zinc ion binding				0	Lung NSC(20;1.56e-05)|Ovarian(52;0.00769)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0393)	OV - Ovarian serous cystadenocarcinoma(33;1.04e-17)			CCCAGCTTCCCCGGGGTTACAC	0.54			NA											7	43					0	0	0.004672	0	0
KCNQ4	9132	broad.mit.edu	37	1	41283859	41283859	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr1:41283859C>A	uc001cgh.1	+	3	511	c.429C>A	c.(427-429)TTC>TTA	p.F143L	KCNQ4_uc001cgi.1_Missense_Mutation_p.F143L	NM_004700	NP_004691	P56696	KCNQ4_HUMAN	potassium voltage-gated channel KQT-like protein	143	Helical; Name=Segment S2; (Potential).				sensory perception of sound	basal plasma membrane|voltage-gated potassium channel complex				central_nervous_system(1)	1	Ovarian(52;0.00769)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;1.38e-17)			TCGTGGTTTTCGGCTTGGAGT	0.617			NA											19	79					6.21321e-17	9.96661e-17	0.00278	1	0
HIVEP3	59269	broad.mit.edu	37	1	42047384	42047384	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr1:42047384C>A	uc001cgz.3	-	4	4298	c.3085G>T	c.(3085-3087)GTG>TTG	p.V1029L	HIVEP3_uc001cha.3_Missense_Mutation_p.V1029L|HIVEP3_uc001cgy.2_RNA	NM_024503	NP_078779	Q5T1R4	ZEP3_HUMAN	human immunodeficiency virus type I enhancer	1029	No DNA binding activity or transactivation activity, but complete prevention of TRAF-dependent NF-Kappa-B activation; associates with TRAF2 and JUN (By similarity).				positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			ovary(4)|large_intestine(1)|central_nervous_system(1)	6	Ovarian(52;0.00769)|all_hematologic(146;0.109)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0367)				GGTGGAGCCACTGGGGCTGGA	0.587			NA											11	34					1.08611e-07	1.38156e-07	0.000978	1	0
CCDC30	728621	broad.mit.edu	37	1	43111805	43111805	+	Splice_Site	SNP	G	G	C			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr1:43111805G>C	uc009vwk.1	+	14	2001	c.1891_splice	c.e14-1	p.N631_splice	CCDC30_uc001chm.2_Splice_Site_p.N329_splice|CCDC30_uc001chn.2_Splice_Site_p.N420_splice	NM_001080850	NP_001074319	Q5VVM6	CCD30_HUMAN	coiled-coil domain containing 30												0						TTTAAACTTAGAATCTTAAGG	0.164			NA											5	16					0	0	0.000602	0	0
ST3GAL3	6487	broad.mit.edu	37	1	44386213	44386213	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr1:44386213G>T	uc001ckc.2	+	10	1059	c.882G>T	c.(880-882)ATG>ATT	p.M294I	ST3GAL3_uc001cjz.2_Missense_Mutation_p.M309I|ST3GAL3_uc001cka.2_Intron|ST3GAL3_uc001ckb.2_Missense_Mutation_p.M363I|ST3GAL3_uc001ckd.2_Missense_Mutation_p.M348I|ST3GAL3_uc001cke.2_Missense_Mutation_p.M278I|ST3GAL3_uc001ckf.2_Missense_Mutation_p.M332I|ST3GAL3_uc001ckg.2_Intron|ST3GAL3_uc001ckh.2_Intron|ST3GAL3_uc001cki.2_Intron|ST3GAL3_uc009vwv.2_Missense_Mutation_p.M264I|ST3GAL3_uc001ckj.2_RNA|ST3GAL3_uc009vww.2_RNA|ST3GAL3_uc001ckk.2_Missense_Mutation_p.M263I|ST3GAL3_uc009vwy.2_Missense_Mutation_p.M200I|ST3GAL3_uc009vwx.2_Intron|ST3GAL3_uc001ckm.2_Intron|ST3GAL3_uc001ckl.2_Intron|ST3GAL3_uc009vwz.2_Missense_Mutation_p.M68I|ST3GAL3_uc001ckn.2_Intron|ST3GAL3_uc001ckp.2_Intron|ST3GAL3_uc001cko.2_Intron|ST3GAL3_uc009vxa.2_Missense_Mutation_p.M81I|ST3GAL3_uc001ckq.2_Intron|ST3GAL3_uc001ckr.2_Intron|ST3GAL3_uc009vxb.2_Intron	NM_006279	NP_006270	Q11203	SIAT6_HUMAN	sialyltransferase 6 isoform j	294	Lumenal (Potential).				protein glycosylation	extracellular region|Golgi cisterna membrane|integral to Golgi membrane	N-acetyllactosaminide alpha-2,3-sialyltransferase activity			ovary(3)	3	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0518)				ATGGCCTCATGGGCCGGGGGG	0.607			NA											15	35					1.56452e-12	2.31028e-12	0.007413	1	0
SLC6A9	6536	broad.mit.edu	37	1	44476516	44476516	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr1:44476516C>G	uc001cll.2	-	3	480	c.288G>C	c.(286-288)CAG>CAC	p.Q96H	SLC6A9_uc009vxe.2_5'UTR|SLC6A9_uc010okm.1_Missense_Mutation_p.Q23H|SLC6A9_uc001clm.2_Missense_Mutation_p.Q42H|SLC6A9_uc009vxd.2_RNA|SLC6A9_uc010okn.1_Missense_Mutation_p.Q42H|SLC6A9_uc001cln.2_Missense_Mutation_p.Q23H|SLC6A9_uc010oko.1_Intron|SLC6A9_uc010okp.1_Intron	NM_201649	NP_964012	P48067	SC6A9_HUMAN	solute carrier family 6 member 9 isoform 2	96	Cytoplasmic (Potential).					integral to plasma membrane|membrane fraction	glycine:sodium symporter activity|neurotransmitter:sodium symporter activity				0	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0511)			Glycine(DB00145)	GTTTGAGGTTCTGGTCCCTCT	0.592			NA											21	42					0	0	0.005443	0	0
FAF1	11124	broad.mit.edu	37	1	51171477	51171478	+	Missense_Mutation	DNP	CC	CC	AA			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr1:51171477_51171478CC>AA	uc009vyx.1	-	8	700_701	c.637_638GG>TT	c.(637-639)GGA>TTA	p.G213L	FAF1_uc009vyw.1_Intron|FAF1_uc001cse.1_Missense_Mutation_p.G213L	NM_007051	NP_008982	Q9UNN5	FAF1_HUMAN	FAS-associated factor 1	213					apoptosis|cytoplasmic sequestering of NF-kappaB|positive regulation of apoptosis|positive regulation of protein complex assembly|proteasomal ubiquitin-dependent protein catabolic process|regulation of protein catabolic process	CD95 death-inducing signaling complex|cytosol|perinuclear region of cytoplasm	heat shock protein binding|NF-kappaB binding|protein kinase binding|protein kinase regulator activity	p.0?(1)		ovary(1)|pancreas(1)	2				GBM - Glioblastoma multiforme(3;3.18e-11)|all cancers(3;0.00526)		AGTACTGCTTCCTGAGAAGTTC	0.431			NA											5	25					0	0	0.004672	0	0
ACOT11	26027	broad.mit.edu	37	1	55066961	55066961	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr1:55066961G>A	uc001cxm.1	+	9	986	c.904G>A	c.(904-906)GTG>ATG	p.V302M	ACOT11_uc001cxj.1_Missense_Mutation_p.V180M|ACOT11_uc001cxl.1_Missense_Mutation_p.V302M	NM_015547	NP_056362	Q8WXI4	ACO11_HUMAN	thioesterase, adipose associated isoform BFIT1	302	Acyl coenzyme A hydrolase 2.				fatty acid metabolic process|intracellular signal transduction|response to cold		acyl-CoA thioesterase activity|carboxylesterase activity			central_nervous_system(1)	1						GGGCGTGTGCGTGGAGGCCTA	0.572	Ovarian(148;1440 1861 22015 32453 51933)		NA											3	45					0	0	0.004672	0	0
C8A	731	broad.mit.edu	37	1	57349308	57349308	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr1:57349308C>T	uc001cyo.2	+	6	941	c.809C>T	c.(808-810)TCA>TTA	p.S270L		NM_000562	NP_000553	P07357	CO8A_HUMAN	complement component 8, alpha polypeptide	270	MACPF.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis	extracellular space|membrane attack complex				ovary(1)|central_nervous_system(1)|skin(1)	3						GTATCCCACTCACAAGACACT	0.408			NA											19	25					0	0	0.00278	0	0
DAB1	1600	broad.mit.edu	37	1	57476916	57476916	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr1:57476916G>C	uc001cys.1	-	15	2148	c.1474C>G	c.(1474-1476)CCA>GCA	p.P492A	DAB1_uc001cyt.1_Missense_Mutation_p.P490A|DAB1_uc001cyq.1_Missense_Mutation_p.P490A|DAB1_uc001cyr.1_Missense_Mutation_p.P406A|DAB1_uc009vzw.1_Missense_Mutation_p.P474A|DAB1_uc009vzx.1_Missense_Mutation_p.P492A	NM_021080	NP_066566	O75553	DAB1_HUMAN	disabled homolog 1	525					cell differentiation|nervous system development					skin(2)|ovary(1)	3						GATTTGGATGGAGAGCTCTGT	0.488			NA											11	67					0	0	0.001855	0	0
SGIP1	84251	broad.mit.edu	37	1	67105493	67105493	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr1:67105493G>T	uc001dcr.2	+	5	422	c.205G>T	c.(205-207)GCG>TCG	p.A69S		NM_032291	NP_115667	Q9BQI5	SGIP1_HUMAN	SH3-domain GRB2-like (endophilin) interacting	69					positive regulation of energy homeostasis|positive regulation of feeding behavior|positive regulation of receptor-mediated endocytosis|response to dietary excess	AP-2 adaptor complex	microtubule binding|phospholipid binding|SH3 domain binding			ovary(3)	3						TGGATTTTATGCGGAAATTGA	0.294			NA											6	39					2.17888e-05	2.52532e-05	0.006214	1	0
LRRC7	57554	broad.mit.edu	37	1	70504868	70504868	+	Nonsense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr1:70504868G>T	uc001dep.2	+	19	3277	c.3247G>T	c.(3247-3249)GAG>TAG	p.E1083*	LRRC7_uc009wbg.2_Nonsense_Mutation_p.E367*|LRRC7_uc001deq.2_Nonsense_Mutation_p.E324*	NM_020794	NP_065845	Q96NW7	LRRC7_HUMAN	leucine rich repeat containing 7	1083						centrosome|focal adhesion|nucleolus	protein binding			ovary(9)|breast(2)|central_nervous_system(2)|liver(1)	14						CCCACCGATGGAGCAAATGTT	0.517			NA											16	36					9.16793e-09	1.2118e-08	0.00499	1	0
C1orf173	127254	broad.mit.edu	37	1	75037079	75037079	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr1:75037079G>A	uc001dgg.2	-	14	4534	c.4315C>T	c.(4315-4317)CGG>TGG	p.R1439W		NM_001002912	NP_001002912	Q5RHP9	CA173_HUMAN	hypothetical protein LOC127254	1439	Glu-rich.									ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	5						GAGGTCTTCCGCTCCAGGGCT	0.612			NA											4	132					0	0	0.000602	0	0
ST6GALNAC5	81849	broad.mit.edu	37	1	77510192	77510192	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr1:77510192C>A	uc001dhi.2	+	3	740	c.565C>A	c.(565-567)CTG>ATG	p.L189M	ST6GALNAC5_uc010ori.1_Intron|ST6GALNAC5_uc009wbw.2_RNA	NM_030965	NP_112227	Q9BVH7	SIA7E_HUMAN	sialyltransferase 7E	189	Lumenal (Potential).				protein glycosylation	integral to Golgi membrane	sialyltransferase activity			pancreas(1)|skin(1)	2						CTACAACAACCTGCATCTCCT	0.597			NA											17	99					5.3912e-06	6.42881e-06	0.006122	1	0
DPYD	1806	broad.mit.edu	37	1	97658647	97658647	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr1:97658647C>A	uc001drv.2	-	20	2737	c.2600G>T	c.(2599-2601)CGT>CTT	p.R867L		NM_000110	NP_000101	Q12882	DPYD_HUMAN	dihydropyrimidine dehydrogenase isoform 1	867					'de novo' pyrimidine base biosynthetic process|purine base catabolic process|thymidine catabolic process|thymine catabolic process|UMP biosynthetic process|uracil catabolic process	cytosol	4 iron, 4 sulfur cluster binding|dihydroorotate oxidase activity|dihydropyrimidine dehydrogenase (NADP+) activity|electron carrier activity|flavin adenine dinucleotide binding|metal ion binding|NADP binding|protein homodimerization activity			ovary(3)|skin(3)|breast(2)	8		all_epithelial(167;0.000185)|all_lung(203;0.00318)|Lung NSC(277;0.00994)		Colorectal(170;0.0165)|Epithelial(280;0.0526)|all cancers(265;0.104)|READ - Rectum adenocarcinoma(84;0.171)|Lung(183;0.216)	Capecitabine(DB01101)|Enfuvirtide(DB00109)	TTCAGCTATACGTGGAACTGG	0.423			NA											10	43					1.3612e-06	1.67559e-06	0.003163	1	0
LPPR4	9890	broad.mit.edu	37	1	99771548	99771548	+	Missense_Mutation	SNP	T	T	C			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr1:99771548T>C	uc001dse.2	+	7	1380	c.1274T>C	c.(1273-1275)GTA>GCA	p.V425A	LPPR4_uc010oue.1_Missense_Mutation_p.V367A	NM_014839	NP_055654	Q7Z2D5	LPPR4_HUMAN	plasticity related gene 1	425							phosphatidate phosphatase activity			ovary(3)	3		all_epithelial(167;3.54e-06)|all_lung(203;0.00139)|Lung NSC(277;0.00202)		Epithelial(280;0.0736)|all cancers(265;0.0975)|COAD - Colon adenocarcinoma(174;0.142)|Lung(183;0.201)|Colorectal(170;0.22)		ACCCCATCTGTAGAAGACCCT	0.493			NA											5	19					0	0	0.001168	0	0
AGL	178	broad.mit.edu	37	1	100368266	100368266	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr1:100368266G>A	uc001dsi.1	+	27	4016	c.3616G>A	c.(3616-3618)GAA>AAA	p.E1206K	AGL_uc001dsj.1_Missense_Mutation_p.E1206K|AGL_uc001dsk.1_Missense_Mutation_p.E1206K|AGL_uc001dsl.1_Missense_Mutation_p.E1206K|AGL_uc001dsm.1_Missense_Mutation_p.E1190K|AGL_uc001dsn.1_Missense_Mutation_p.E1189K	NM_000642	NP_000633	P35573	GDE_HUMAN	amylo-1,6-glucosidase,	1206	4-alpha-glucanotransferase.				glucose metabolic process|glycogen biosynthetic process|glycogen catabolic process	cytosol|isoamylase complex|nucleus	4-alpha-glucanotransferase activity|amylo-alpha-1,6-glucosidase activity|cation binding			ovary(1)|central_nervous_system(1)|skin(1)	3		all_epithelial(167;2.2e-06)|all_lung(203;0.000295)|Lung NSC(277;0.00131)		Epithelial(280;0.15)|COAD - Colon adenocarcinoma(174;0.151)|Lung(183;0.209)|all cancers(265;0.237)		AGTCATACAGGAAGCAATGCA	0.408			NA											10	37					0	0	0.001855	0	0
COL11A1	1301	broad.mit.edu	37	1	103385898	103385898	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr1:103385898G>T	uc001dul.2	-	49	4049	c.3731C>A	c.(3730-3732)TCT>TAT	p.S1244Y	COL11A1_uc001duk.2_Missense_Mutation_p.S440Y|COL11A1_uc001dum.2_Missense_Mutation_p.S1256Y|COL11A1_uc001dun.2_Missense_Mutation_p.S1205Y|COL11A1_uc009weh.2_Missense_Mutation_p.S1128Y	NM_001854	NP_001845	P12107	COBA1_HUMAN	alpha 1 type XI collagen isoform A	1244	Triple-helical region.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			ovary(6)|breast(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	12		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		TGAACCAACAGACCCTGGGGG	0.363			NA											25	70					2.61193e-14	3.97131e-14	0.009535	1	0
KCNA10	3744	broad.mit.edu	37	1	111060633	111060633	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr1:111060633C>A	uc001dzt.1	-	1	1165	c.777G>T	c.(775-777)AAG>AAT	p.K259N		NM_005549	NP_005540	Q16322	KCA10_HUMAN	potassium voltage-gated channel, shaker-related	259						voltage-gated potassium channel complex	intracellular cyclic nucleotide activated cation channel activity|voltage-gated potassium channel activity			ovary(3)|large_intestine(1)	4		all_cancers(81;4.57e-06)|all_epithelial(167;1.52e-05)|all_lung(203;0.000152)|Lung NSC(277;0.000301)		Lung(183;0.0238)|all cancers(265;0.0874)|Colorectal(144;0.103)|Epithelial(280;0.116)|LUSC - Lung squamous cell carcinoma(189;0.134)		AGAGGACTGTCTTGCTCATGT	0.547			NA											32	70					8.73648e-17	1.39991e-16	0.004289	1	0
KCNA2	3737	broad.mit.edu	37	1	111146816	111146816	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr1:111146816C>A	uc001dzu.2	-	2	1085	c.589G>T	c.(589-591)GGT>TGT	p.G197C	KCNA2_uc009wfv.1_Missense_Mutation_p.G197C|KCNA2_uc009wfw.2_Missense_Mutation_p.G197C	NM_004974	NP_004965	P16389	KCNA2_HUMAN	potassium voltage-gated channel, shaker-related	197						juxtaparanode region of axon|voltage-gated potassium channel complex	delayed rectifier potassium channel activity			ovary(1)	1		all_cancers(81;5.55e-06)|all_epithelial(167;1.87e-05)|all_lung(203;0.000199)|Lung NSC(277;0.000398)		Colorectal(144;0.00878)|Lung(183;0.0234)|all cancers(265;0.0492)|Epithelial(280;0.0529)|COAD - Colon adenocarcinoma(174;0.131)|LUSC - Lung squamous cell carcinoma(189;0.133)|READ - Rectum adenocarcinoma(129;0.191)		ACCCCACTACCATGCATGTCT	0.468	Pancreas(18;568 735 10587 23710 36357)		NA											14	56					0.000308642	0.000341227	0.003163	1	0
HAO2	51179	broad.mit.edu	37	1	119927405	119927405	+	Missense_Mutation	SNP	A	A	G			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr1:119927405A>G	uc001ehq.1	+	5	642	c.290A>G	c.(289-291)CAA>CGA	p.Q97R	HAO2_uc001ehr.1_Missense_Mutation_p.Q97R	NM_001005783	NP_001005783	Q9NYQ3	HAOX2_HUMAN	hydroxyacid oxidase 2	97	FMN hydroxy acid dehydrogenase.				fatty acid alpha-oxidation	peroxisome	(S)-2-hydroxy-acid oxidase activity			ovary(2)|skin(2)	4	all_neural(166;0.187)	all_lung(203;1.06e-06)|Lung NSC(69;7.5e-06)|all_epithelial(167;0.000284)		Lung(183;0.0155)|LUSC - Lung squamous cell carcinoma(189;0.0856)		ACAGCTGCCCAAGCGGCTGGT	0.547			NA											7	20					0	0	0.006214	0	0
PPIAL4E	730262	broad.mit.edu	37	1	148644433	148644433	+	Silent	SNP	T	T	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr1:148644433T>A	uc010paz.1	+	1	423	c.348T>A	c.(346-348)GCT>GCA	p.A116A		NM_001144032	NP_001137504	F5H284	F5H284_HUMAN	peptidylprolyl isomerase A (cyclophilin A)-like	116					protein folding		peptidyl-prolyl cis-trans isomerase activity				0						TCATCTGTGCTGCCAAGACTG	0.478			NA											48	91					0	0	0.00361	0	0
HIST2H2AC	8338	broad.mit.edu	37	1	149858795	149858795	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr1:149858795G>T	uc001etd.2	+	1	271	c.271G>T	c.(271-273)GAC>TAC	p.D91Y	HIST2H2BE_uc001etc.2_5'Flank	NM_003517	NP_003508	Q16777	H2A2C_HUMAN	histone cluster 2, H2ac	91					nucleosome assembly	nucleosome|nucleus	DNA binding			ovary(1)|skin(1)	2	Breast(34;0.0124)|all_hematologic(923;0.127)		STAD - Stomach adenocarcinoma(528;0.133)|LUSC - Lung squamous cell carcinoma(543;0.221)			CATCCGCAACGACGAGGAACT	0.597			NA											10	53					2.35188e-11	3.34985e-11	0.006122	1	0
SV2A	9900	broad.mit.edu	37	1	149885080	149885080	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr1:149885080C>T	uc001etg.2	-	2	804	c.313G>A	c.(313-315)GAG>AAG	p.E105K	SV2A_uc001eth.2_Missense_Mutation_p.E105K	NM_014849	NP_055664	Q7L0J3	SV2A_HUMAN	synaptic vesicle glycoprotein 2	105	Cytoplasmic (Potential).				neurotransmitter transport	cell junction|endoplasmic reticulum|integral to membrane|synaptic vesicle membrane	transmembrane transporter activity			ovary(6)|pancreas(1)	7	Breast(34;0.00769)|all_hematologic(923;0.127)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.221)|STAD - Stomach adenocarcinoma(528;0.247)		Levetiracetam(DB01202)	CCCCCAGACTCTGCCCGGGGA	0.637			NA											56	180					0	0	0.00361	0	0
TCHH	7062	broad.mit.edu	37	1	152081942	152081942	+	Silent	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr1:152081942G>T	uc001ezp.2	-	2	3751	c.3751C>A	c.(3751-3753)CGG>AGG	p.R1251R	TCHH_uc009wne.1_Silent_p.R1251R	NM_007113	NP_009044	Q07283	TRHY_HUMAN	trichohyalin	1251					keratinization	cytoskeleton	calcium ion binding			ovary(3)|kidney(1)|central_nervous_system(1)	5	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TCCAACTGCCGGAACTGTTCA	0.507			NA											38	18					1.04594e-18	1.70913e-18	0.00623	1	0
HRNR	388697	broad.mit.edu	37	1	152191721	152191721	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr1:152191721C>A	uc001ezt.1	-	3	2460	c.2384G>T	c.(2383-2385)GGG>GTG	p.G795V		NM_001009931	NP_001009931	Q86YZ3	HORN_HUMAN	hornerin	795	8.				keratinization		calcium ion binding|protein binding			skin(2)|ovary(1)	3	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TGTGCCAGACCCGTGTTGGCC	0.602			NA											30	16					1.50538e-07	1.90511e-07	0.00632	1	0
FLG2	388698	broad.mit.edu	37	1	152324460	152324460	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr1:152324460G>C	uc001ezw.3	-	3	5875	c.5802C>G	c.(5800-5802)CAC>CAG	p.H1934Q	uc001ezv.2_Intron	NM_001014342	NP_001014364	Q5D862	FILA2_HUMAN	filaggrin family member 2	1934	Filaggrin 8.						calcium ion binding|structural molecule activity			ovary(10)|skin(5)|upper_aerodigestive_tract(1)|breast(1)	17	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CATGACTAGGGTGGCCATGTT	0.522			NA											108	113					0	0	0.00361	0	0
SPRR2D	6703	broad.mit.edu	37	1	153012776	153012776	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr1:153012776G>A	uc001fbb.2	-	2	107	c.47C>T	c.(46-48)CCT>CTT	p.P16L	SPRR2D_uc009wnz.2_RNA	NM_006945	NP_008876	P22532	SPR2D_HUMAN	small proline-rich protein 2D	16					keratinization	cornified envelope|cytoplasm					0	Lung NSC(65;1.49e-28)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.171)			GGGGCACACAGGAGGTGGCTG	0.582			NA											69	51					0	0	0.00361	0	0
C1orf43	25912	broad.mit.edu	37	1	154180095	154180095	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr1:154180095C>A	uc001fei.2	-	7	986	c.596G>T	c.(595-597)CGA>CTA	p.R199L	C1orf189_uc001fee.1_5'Flank|C1orf43_uc001fef.1_Missense_Mutation_p.R96L|C1orf43_uc001feg.2_Missense_Mutation_p.R165L|C1orf43_uc001feh.2_Missense_Mutation_p.R147L|C1orf43_uc001fej.2_Missense_Mutation_p.R181L|C1orf43_uc009wos.1_3'UTR	NM_001098616	NP_001092086	Q9BWL3	CA043_HUMAN	hypothetical protein LOC25912 isoform 3	199						integral to membrane	coenzyme binding|oxidoreductase activity				0	all_lung(78;1.98e-30)|Lung NSC(65;2.87e-28)|Hepatocellular(266;0.0877)					CTGGTGATGTCGCTGAGAGCT	0.512			NA											14	70					7.93312e-07	9.78967e-07	0.00245	1	0
SYT11	23208	broad.mit.edu	37	1	155851152	155851152	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr1:155851152C>A	uc001fmg.2	+	4	1412	c.1149C>A	c.(1147-1149)GAC>GAA	p.D383E	SYT11_uc010pgq.1_Missense_Mutation_p.D76E	NM_152280	NP_689493	Q9BT88	SYT11_HUMAN	synaptotagmin XI	383	C2 2.|Cytoplasmic (Potential).					cell junction|synaptic vesicle membrane	protein binding|transporter activity			ovary(1)|skin(1)	2	Hepatocellular(266;0.133)|all_hematologic(923;0.145)|all_neural(408;0.195)		OV - Ovarian serous cystadenocarcinoma(3;0.000162)			TCGTTATCGACTTCGATCGCA	0.527			NA											191	130					1.91102e-82	3.59252e-82	0.00361	1	0
SYT11	23208	broad.mit.edu	37	1	155851170	155851170	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr1:155851170G>C	uc001fmg.2	+	4	1430	c.1167G>C	c.(1165-1167)AAG>AAC	p.K389N	SYT11_uc010pgq.1_Missense_Mutation_p.K82N	NM_152280	NP_689493	Q9BT88	SYT11_HUMAN	synaptotagmin XI	389	C2 2.|Cytoplasmic (Potential).					cell junction|synaptic vesicle membrane	protein binding|transporter activity			ovary(1)|skin(1)	2	Hepatocellular(266;0.133)|all_hematologic(923;0.145)|all_neural(408;0.195)		OV - Ovarian serous cystadenocarcinoma(3;0.000162)			GCACCACCAAGAATGAGGTGG	0.562			NA											70	166					0	0	0.00361	0	0
NTRK1	4914	broad.mit.edu	37	1	156838013	156838013	+	Silent	SNP	C	C	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr1:156838013C>T	uc001fqh.1	+	5	602	c.546C>T	c.(544-546)CCC>CCT	p.P182P	NTRK1_uc001fqf.1_Silent_p.P152P|NTRK1_uc009wsi.1_5'UTR|NTRK1_uc001fqi.1_Silent_p.P182P|NTRK1_uc009wsk.1_Silent_p.P182P	NM_002529	NP_002520	P04629	NTRK1_HUMAN	neurotrophic tyrosine kinase, receptor, type 1	182	LRRCT.|Extracellular (Potential).				activation of adenylate cyclase activity|activation of MAPKK activity|activation of phospholipase C activity|cell differentiation|nerve growth factor receptor signaling pathway|nervous system development|phosphatidylinositol-mediated signaling|Ras protein signal transduction	endosome|integral to plasma membrane	ATP binding|neurotrophin receptor activity|transmembrane receptor protein serine/threonine kinase activity|transmembrane receptor protein tyrosine kinase activity			lung(9)|ovary(6)|stomach(1)|central_nervous_system(1)	17	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)				Imatinib(DB00619)	GGCAAGGGCCCCTGGCCCACA	0.647			NA	T	TPM3|TPR|TFG	papillary thyroid					TSP Lung(10;0.080)			11	13					0	0	0.000978	0	0
ARHGEF11	9826	broad.mit.edu	37	1	156914841	156914841	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr1:156914841C>A	uc001fqo.2	-	29	3881	c.2841G>T	c.(2839-2841)AGG>AGT	p.R947S	ARHGEF11_uc010phu.1_Missense_Mutation_p.R363S|ARHGEF11_uc001fqn.2_Missense_Mutation_p.R987S	NM_014784	NP_055599	O15085	ARHGB_HUMAN	Rho guanine nucleotide exchange factor (GEF) 11	947					actin cytoskeleton organization|apoptosis|axon guidance|cellular component movement|cytokinesis|establishment of cell polarity|G-protein coupled receptor protein signaling pathway|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|positive regulation of transcription, DNA-dependent|regulation of cell growth|regulation of Rho protein signal transduction|Rho protein signal transduction|striated muscle contraction	cytosol|Golgi apparatus|plasma membrane	G-protein-coupled receptor binding|GTPase activator activity|Rho guanyl-nucleotide exchange factor activity|signal transducer activity			ovary(3)|skin(2)|pleura(1)|lung(1)|kidney(1)|pancreas(1)	9	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					GGTTGCTGGCCCTCTCCAGGG	0.562			NA											98	72					1.11883e-47	2.07185e-47	0.00361	1	0
ARHGEF11	9826	broad.mit.edu	37	1	156918261	156918261	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr1:156918261G>C	uc001fqo.2	-	22	2875	c.1835C>G	c.(1834-1836)TCT>TGT	p.S612C	ARHGEF11_uc010phu.1_Missense_Mutation_p.S28C|ARHGEF11_uc001fqn.2_Missense_Mutation_p.S652C|ARHGEF11_uc001fqp.1_Missense_Mutation_p.S131C	NM_014784	NP_055599	O15085	ARHGB_HUMAN	Rho guanine nucleotide exchange factor (GEF) 11	612					actin cytoskeleton organization|apoptosis|axon guidance|cellular component movement|cytokinesis|establishment of cell polarity|G-protein coupled receptor protein signaling pathway|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|positive regulation of transcription, DNA-dependent|regulation of cell growth|regulation of Rho protein signal transduction|Rho protein signal transduction|striated muscle contraction	cytosol|Golgi apparatus|plasma membrane	G-protein-coupled receptor binding|GTPase activator activity|Rho guanyl-nucleotide exchange factor activity|signal transducer activity			ovary(3)|skin(2)|pleura(1)|lung(1)|kidney(1)|pancreas(1)	9	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					GAGGCTTTCAGAGCGGCCCAG	0.572			NA											15	44					0	0	0.007413	0	0
CD1C	911	broad.mit.edu	37	1	158262459	158262459	+	Silent	SNP	C	C	A	rs3138103	byFrequency	TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr1:158262459C>A	uc001fru.2	+	4	976	c.684C>A	c.(682-684)TCC>TCA	p.S228S	CD1C_uc001frv.2_Silent_p.S31S	NM_001765	NP_001756	P29017	CD1C_HUMAN	CD1C antigen precursor	228	Extracellular (Potential).|Ig-like.				antigen processing and presentation|T cell activation involved in immune response	endosome membrane|integral to plasma membrane	endogenous lipid antigen binding|exogenous lipid antigen binding|glycolipid binding|lipopeptide binding			ovary(2)|skin(1)|pancreas(1)	4	all_hematologic(112;0.0378)					GTCATGCCTCCGGCTTCTACC	0.532			NA											28	20					1.77063e-15	2.7715e-15	0.005443	1	0
SPTA1	6708	broad.mit.edu	37	1	158609404	158609404	+	Nonsense_Mutation	SNP	G	G	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr1:158609404G>A	uc001fst.1	-	35	5147	c.4948C>T	c.(4948-4950)CAG>TAG	p.Q1650*		NM_003126	NP_003117	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1	1650	Spectrin 16.				actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|breast(1)	8	all_hematologic(112;0.0378)					TCCAATAGCTGATGCTTCTTG	0.478			NA											56	58					0	0	0.00361	0	0
SPTA1	6708	broad.mit.edu	37	1	158646020	158646020	+	Silent	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr1:158646020G>T	uc001fst.1	-	8	1222	c.1023C>A	c.(1021-1023)ATC>ATA	p.I341I		NM_003126	NP_003117	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1	341	Spectrin 4.				actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|breast(1)	8	all_hematologic(112;0.0378)					TCATCTCCTGGATCTGAGGTG	0.468			NA											90	71					3.19611e-63	5.98566e-63	0.00361	1	0
OR6K3	391114	broad.mit.edu	37	1	158687187	158687187	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr1:158687187C>G	uc010pip.1	-	1	767	c.767G>C	c.(766-768)TGT>TCT	p.C256S		NM_001005327	NP_001005327	Q8NGY3	OR6K3_HUMAN	olfactory receptor, family 6, subfamily K,	256	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|kidney(1)|central_nervous_system(1)	3	all_hematologic(112;0.0378)					GTGGCCTGCACAGGTAGAAAA	0.448			NA											17	15					0	0	0.004007	0	0
OR10J5	127385	broad.mit.edu	37	1	159505133	159505133	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr1:159505133G>T	uc010piw.1	-	1	665	c.665C>A	c.(664-666)TCT>TAT	p.S222Y		NM_001004469	NP_001004469	Q8NHC4	O10J5_HUMAN	olfactory receptor, family 10, subfamily J,	222	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)	3	all_hematologic(112;0.0429)					AAGGATGGAAGAGATGACAAG	0.443			NA											29	23					1.1423e-28	2.01495e-28	0.009535	1	0
SLAMF6	114836	broad.mit.edu	37	1	160461040	160461040	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr1:160461040G>A	uc001fwe.1	-	3	581	c.521C>T	c.(520-522)TCA>TTA	p.S174L	SLAMF6_uc001fwd.1_Missense_Mutation_p.S174L|SLAMF6_uc010pjh.1_Missense_Mutation_p.S125L|SLAMF6_uc010pji.1_Missense_Mutation_p.S63L|SLAMF6_uc010pjj.1_Missense_Mutation_p.S63L|SLAMF6_uc009wtm.1_Missense_Mutation_p.S125L	NM_052931	NP_443163	Q96DU3	SLAF6_HUMAN	activating NK receptor precursor	174	Extracellular (Potential).|Ig-like.					integral to membrane|plasma membrane	receptor activity			ovary(1)|skin(1)	2	all_cancers(52;1.05e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.0923)			TGGCTGACTTGAAAGTGTGTT	0.473			NA											33	67					0	0	0.00874	0	0
OLFML2B	25903	broad.mit.edu	37	1	161967956	161967956	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr1:161967956G>C	uc001gbu.2	-	6	1557	c.1133C>G	c.(1132-1134)CCC>CGC	p.P378R	OLFML2B_uc010pkq.1_Missense_Mutation_p.P379R	NM_015441	NP_056256	Q68BL8	OLM2B_HUMAN	olfactomedin-like 2B precursor	378										skin(1)	1	all_hematologic(112;0.156)		BRCA - Breast invasive adenocarcinoma(70;0.0172)			TGAGGTCGAGGGCTGTGGCAG	0.627			NA											51	124					0	0	0.00361	0	0
LMX1A	4009	broad.mit.edu	37	1	165175158	165175158	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr1:165175158G>C	uc001gcy.1	-	7	1152	c.931C>G	c.(931-933)CCC>GCC	p.P311A	LMX1A_uc001gcz.1_Missense_Mutation_p.P311A|LMX1A_uc001gcw.1_Missense_Mutation_p.P29A|LMX1A_uc001gcx.1_Missense_Mutation_p.P62A	NM_177398	NP_796372	Q8TE12	LMX1A_HUMAN	LIM homeobox transcription factor 1, alpha	311						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(3)|upper_aerodigestive_tract(1)|pancreas(1)	5	all_hematologic(923;0.248)					TGTCGGAAGGGATCTGAGCTG	0.587			NA											11	62					0	0	0.008291	0	0
NME7	29922	broad.mit.edu	37	1	169292368	169292368	+	Missense_Mutation	SNP	T	T	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr1:169292368T>A	uc001gfu.2	-	3	503	c.265A>T	c.(265-267)AGT>TGT	p.S89C	NME7_uc010plq.1_RNA|NME7_uc001gft.2_Missense_Mutation_p.S53C|NME7_uc001gfv.1_Missense_Mutation_p.S89C	NM_013330	NP_037462	Q9Y5B8	NDK7_HUMAN	nucleoside diphosphate kinase 7 isoform a	89	DM10.				CTP biosynthetic process|GTP biosynthetic process|UTP biosynthetic process	centrosome	ATP binding|metal ion binding|nucleoside diphosphate kinase activity			central_nervous_system(1)	1	all_hematologic(923;0.208)					TCTTTCCTACTGCCCAGCTGG	0.358			NA											27	24					0	0	0.009535	0	0
F5	2153	broad.mit.edu	37	1	169529939	169529939	+	Missense_Mutation	SNP	C	C	T	rs118203912		TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr1:169529939C>T	uc001ggg.1	-	4	584	c.439G>A	c.(439-441)GAA>AAA	p.E147K	F5_uc010plr.1_RNA	NM_000130	NP_000121	P12259	FA5_HUMAN	coagulation factor V precursor	147	F5/8 type A 1.|Plastocyanin-like 1.				cell adhesion|platelet activation|platelet degranulation	plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity			ovary(3)|large_intestine(1)|central_nervous_system(1)|skin(1)	6	all_hematologic(923;0.208)				Drotrecogin alfa(DB00055)	TAGGTGTATTCTCGGCCTGGA	0.517			NA											33	103					0	0	0.007835	0	0
C1orf129	80133	broad.mit.edu	37	1	170964581	170964581	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr1:170964581G>T	uc001ghg.2	+	13	1376	c.1246G>T	c.(1246-1248)GTG>TTG	p.V416L	C1orf129_uc009wvy.2_Missense_Mutation_p.V223L|C1orf129_uc010plz.1_Missense_Mutation_p.V416L	NM_025063	NP_079339	Q5TGP6	CA129_HUMAN	hypothetical protein LOC80133 isoform 2	416							binding			pancreas(1)	1	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					CAGGAAAGCGGTGGCCCAGTA	0.463			NA											47	31					2.14674e-31	3.82758e-31	0.00361	1	0
PRDX6	9588	broad.mit.edu	37	1	173455480	173455480	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr1:173455480G>T	uc001giy.1	+	4	537	c.486G>T	c.(484-486)AGG>AGT	p.R162S		NM_004905	NP_004896	P30041	PRDX6_HUMAN	peroxiredoxin 6	162	Thioredoxin.				cell redox homeostasis|phospholipid catabolic process	cytoplasmic membrane-bounded vesicle|cytosol|lysosome	peroxiredoxin activity|phospholipase A2 activity|protein binding			central_nervous_system(1)	1						AGATTCTCAGGGTAGTCATCT	0.443			NA											90	75					1.07597e-44	1.98507e-44	0.00361	1	0
RABGAP1L	9910	broad.mit.edu	37	1	174190250	174190250	+	Silent	SNP	C	C	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr1:174190250C>T	uc001gjx.2	+	3	474	c.279C>T	c.(277-279)GCC>GCT	p.A93A	RABGAP1L_uc009wwq.1_Silent_p.A93A|RABGAP1L_uc001gjw.2_Silent_p.A56A	NM_014857	NP_055672	Q5R372	RBG1L_HUMAN	RAB GTPase activating protein 1-like isoform A	93					regulation of protein localization	early endosome|Golgi apparatus|nucleus	Rab GTPase activator activity			ovary(2)|lung(1)|kidney(1)	4						ATATTCCAGCCAGCCAAACAA	0.368			NA											57	62					0	0	0.00361	0	0
RFWD2	64326	broad.mit.edu	37	1	176175712	176175712	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr1:176175712C>G	uc001gku.1	-	1	659	c.403G>C	c.(403-405)GTA>CTA	p.V135L	RFWD2_uc001gkv.1_Missense_Mutation_p.V135L|RFWD2_uc001gkw.1_5'UTR	NM_022457	NP_071902	Q8NHY2	RFWD2_HUMAN	ring finger and WD repeat domain 2 isoform a	135					DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	centrosome|cytosol|focal adhesion|nuclear speck	protein binding|ubiquitin-protein ligase activity|zinc ion binding				0						ACCCACCATACGAAGTCGTTG	0.597	Ovarian(134;1413 1765 5706 35534 51541)		NA											10	57					0	0	0.003163	0	0
ASTN1	460	broad.mit.edu	37	1	176934321	176934321	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr1:176934321G>T	uc001glc.2	-	9	1788	c.1576C>A	c.(1576-1578)CAG>AAG	p.Q526K	ASTN1_uc001glb.1_Missense_Mutation_p.Q526K|ASTN1_uc001gld.1_Missense_Mutation_p.Q526K|ASTN1_uc009wwx.1_Missense_Mutation_p.Q526K	NM_004319	NP_004310	O14525	ASTN1_HUMAN	astrotactin isoform 1	534					cell migration|neuron cell-cell adhesion	integral to membrane				ovary(6)|skin(5)|central_nervous_system(2)|large_intestine(1)|lung(1)	15						TCAGAGGGCTGCTCTCCCAAA	0.388			NA											37	32					2.51966e-14	3.83494e-14	0.00361	1	0
ASTN1	460	broad.mit.edu	37	1	177001626	177001626	+	Silent	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr1:177001626G>T	uc001glc.2	-	3	1043	c.831C>A	c.(829-831)GGC>GGA	p.G277G	ASTN1_uc001glb.1_Silent_p.G277G|ASTN1_uc001gld.1_Silent_p.G277G|ASTN1_uc009wwx.1_Silent_p.G277G|ASTN1_uc001gle.3_RNA	NM_004319	NP_004310	O14525	ASTN1_HUMAN	astrotactin isoform 1	277					cell migration|neuron cell-cell adhesion	integral to membrane				ovary(6)|skin(5)|central_nervous_system(2)|large_intestine(1)|lung(1)	15						TTTCATTGCAGCCCTGCAGGG	0.597			NA											88	53					4.04957e-52	7.55548e-52	0.00361	1	0
FAM5B	57795	broad.mit.edu	37	1	177249868	177249868	+	Missense_Mutation	SNP	A	A	C			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr1:177249868A>C	uc001glf.2	+	8	1868	c.1556A>C	c.(1555-1557)CAG>CCG	p.Q519P	FAM5B_uc001glg.2_Missense_Mutation_p.Q414P	NM_021165	NP_066988	Q9C0B6	FAM5B_HUMAN	family with sequence similarity 5, member B	519						extracellular region				skin(3)|ovary(2)|upper_aerodigestive_tract(1)	6						TACCTGCTGCAGAAGCAGGAT	0.587			NA											18	16					0	0	0.008871	0	0
ABL2	27	broad.mit.edu	37	1	179084056	179084056	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr1:179084056C>A	uc001gmj.3	-	9	1805	c.1518G>T	c.(1516-1518)CAG>CAT	p.Q506H	ABL2_uc010pnf.1_Missense_Mutation_p.Q506H|ABL2_uc010png.1_Missense_Mutation_p.Q485H|ABL2_uc010pnh.1_Missense_Mutation_p.Q485H|ABL2_uc009wxe.2_Missense_Mutation_p.Q485H|ABL2_uc001gmg.3_Missense_Mutation_p.Q491H|ABL2_uc001gmi.3_Missense_Mutation_p.Q491H|ABL2_uc001gmh.3_Missense_Mutation_p.Q470H|ABL2_uc010pne.1_Missense_Mutation_p.Q470H	NM_007314	NP_009298	P42684	ABL2_HUMAN	arg tyrosine kinase isoform b	506	Protein kinase.				axon guidance|cell adhesion|peptidyl-tyrosine phosphorylation|positive regulation of oxidoreductase activity|signal transduction	cytoskeleton|cytosol	ATP binding|magnesium ion binding|manganese ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding			lung(8)|breast(3)|ovary(2)|central_nervous_system(1)	14					Adenosine triphosphate(DB00171)|Dasatinib(DB01254)	ATCCCTCAGGCTGTTCCATTC	0.398			NA	T	ETV6	AML								52	32					4.17463e-26	7.30314e-26	0.00361	1	0
ZNF648	127665	broad.mit.edu	37	1	182026681	182026681	+	Silent	SNP	T	T	G			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr1:182026681T>G	uc001goz.2	-	2	673	c.465A>C	c.(463-465)GCA>GCC	p.A155A		NM_001009992	NP_001009992	Q5T619	ZN648_HUMAN	zinc finger protein 648	155					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						CGTCCTGGTTTGCCCCCGAGT	0.552	NSCLC(71;908 1374 5429 20458 35642)		NA											19	28					0	0	0.008871	0	0
HMCN1	83872	broad.mit.edu	37	1	185984364	185984364	+	Missense_Mutation	SNP	A	A	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr1:185984364A>T	uc001grq.1	+	31	4933	c.4704A>T	c.(4702-4704)GAA>GAT	p.E1568D		NM_031935	NP_114141	Q96RW7	HMCN1_HUMAN	hemicentin 1 precursor	1568	Ig-like C2-type 13.				response to stimulus|visual perception	basement membrane	calcium ion binding			ovary(22)|skin(1)	23						TTAAACTGGAATGTGAAACAC	0.398			NA											36	24					0	0	0.00623	0	0
B3GALT2	8707	broad.mit.edu	37	1	193149690	193149690	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr1:193149690G>T	uc001gtc.3	-	2	1718	c.1003C>A	c.(1003-1005)CGC>AGC	p.R335S	CDC73_uc001gtb.2_Intron	NM_003783	NP_003774	O43825	B3GT2_HUMAN	UDP-Gal:betaGlcNAc beta	335	Lumenal (Potential).				protein glycosylation	Golgi membrane|integral to membrane	UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity			ovary(1)	1						TGCAAACGGCGGATACCTAAA	0.433			NA											18	12					2.39187e-15	3.71838e-15	0.008871	1	0
CFH	3075	broad.mit.edu	37	1	196706718	196706718	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr1:196706718G>A	uc001gtj.3	+	17	2950	c.2710G>A	c.(2710-2712)GGT>AGT	p.G904S		NM_000186	NP_000177	P08603	CFAH_HUMAN	complement factor H isoform a precursor	904	Sushi 15.				complement activation, alternative pathway	extracellular space				skin(4)|ovary(1)|breast(1)	6						TTGTGAGGGTGGTTTCAGGAT	0.393			NA											8	70					0	0	0.004482	0	0
ASPM	259266	broad.mit.edu	37	1	197071204	197071204	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr1:197071204C>A	uc001gtu.2	-	18	7434	c.7177G>T	c.(7177-7179)GCT>TCT	p.A2393S	ASPM_uc001gtv.2_Intron|ASPM_uc001gtw.3_Missense_Mutation_p.A241S	NM_018136	NP_060606	Q8IZT6	ASPM_HUMAN	asp (abnormal spindle)-like, microcephaly	2393	IQ 24.				mitosis	cytoplasm|nucleus	calmodulin binding			ovary(4)|central_nervous_system(2)	6						CTGAATGCAGCCTGAAGGATC	0.448			NA											85	156					3.21569e-47	5.94003e-47	0.00361	1	0
KIF14	9928	broad.mit.edu	37	1	200534316	200534316	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr1:200534316C>T	uc010ppk.1	-	25	4391	c.3952G>A	c.(3952-3954)GTA>ATA	p.V1318I	KIF14_uc010ppj.1_Missense_Mutation_p.V827I	NM_014875	NP_055690	Q15058	KIF14_HUMAN	kinesin family member 14	1318	Required for CIT-binding.				microtubule-based movement	cytoplasm|microtubule|nucleus|spindle	ATP binding|microtubule motor activity|protein binding			breast(3)|ovary(2)|skin(2)	7						ATTAGCACTACTAGCTGCTCA	0.383			NA											72	142					0	0	0.00361	0	0
GPR25	2848	broad.mit.edu	37	1	200842745	200842745	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr1:200842745G>C	uc001gvn.1	+	1	580	c.580G>C	c.(580-582)GAG>CAG	p.E194Q		NM_005298	NP_005289	O00155	GPR25_HUMAN	G protein-coupled receptor 25	194	Extracellular (Potential).					integral to plasma membrane				ovary(1)	1						GTGCGGCGAGGAGCCCTCCCA	0.716			NA											2	12					0	0	0.004672	0	0
GPR25	2848	broad.mit.edu	37	1	200842866	200842866	+	Missense_Mutation	SNP	A	A	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr1:200842866A>T	uc001gvn.1	+	1	701	c.701A>T	c.(700-702)CAC>CTC	p.H234L		NM_005298	NP_005289	O00155	GPR25_HUMAN	G protein-coupled receptor 25	234	Cytoplasmic (Potential).					integral to plasma membrane				ovary(1)	1						CGGCCGCCGCACGTGGGTCGG	0.687			NA											20	62					0	0	0.00632	0	0
GPR25	2848	broad.mit.edu	37	1	200842882	200842882	+	Silent	SNP	G	G	C			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr1:200842882G>C	uc001gvn.1	+	1	717	c.717G>C	c.(715-717)CGG>CGC	p.R239R		NM_005298	NP_005289	O00155	GPR25_HUMAN	G protein-coupled receptor 25	239	Cytoplasmic (Potential).					integral to plasma membrane				ovary(1)	1						GTCGGGCCCGGAGGAACTCGC	0.692			NA											21	61					0	0	0.007291	0	0
IGFN1	91156	broad.mit.edu	37	1	201185763	201185763	+	Silent	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr1:201185763C>A	uc001gwc.2	+	5	1729	c.957C>A	c.(955-957)ACC>ACA	p.T319T	IGFN1_uc001gwb.2_RNA	NM_178275	NP_840059			RecName: Full=Immunoglobulin-like and fibronectin type III domain-containing protein 1; AltName: Full=EEF1A2-binding protein 1; AltName: Full=KY-interacting protein 1;											ovary(2)|pancreas(1)	3						CTGACAGCACCACCTTCACGG	0.652			NA											31	42					3.90053e-15	6.03547e-15	0.002445	1	0
MYOG	4656	broad.mit.edu	37	1	203054631	203054631	+	Silent	SNP	C	C	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr1:203054631C>T	uc001gzd.2	-	1	747	c.459G>A	c.(457-459)GGG>GGA	p.G153G		NM_002479	NP_002470	P15173	MYOG_HUMAN	myogenin	153					muscle cell fate commitment|positive regulation of muscle cell differentiation|positive regulation of transcription from RNA polymerase II promoter	transcription factor complex	E-box binding|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity			skin(2)	2						CTGGCTGGGGCCCGCCCCCGC	0.692			NA											7	12					0	0	0.00308	0	0
ADORA1	134	broad.mit.edu	37	1	203134490	203134490	+	Missense_Mutation	SNP	A	A	G			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr1:203134490A>G	uc001gze.1	+	4	876	c.443A>G	c.(442-444)AAT>AGT	p.N148S	FMOD_uc010pqi.1_Intron|ADORA1_uc001gzf.1_Missense_Mutation_p.N148S|ADORA1_uc010pqg.1_Missense_Mutation_p.N80S|ADORA1_uc009xak.1_Silent_p.Q73Q|ADORA1_uc010pqh.1_Missense_Mutation_p.N181S	NM_000674	NP_000665	P30542	AA1R_HUMAN	adenosine A1 receptor	148	Extracellular (Potential).				induction of apoptosis by extracellular signals|inflammatory response|nervous system development|phagocytosis	integral to plasma membrane				large_intestine(1)	1					Aminophylline(DB01223)|Caffeine(DB00201)|Defibrotide(DB04932)|Gabapentin(DB00996)|Imipramine(DB00458)|Pegademase bovine(DB00061)|Theophylline(DB00277)	GGCTGGAACAATCTGAGTGCG	0.622			NA											13	34					0	0	0.00499	0	0
PPP1R15B	84919	broad.mit.edu	37	1	204379825	204379825	+	Nonsense_Mutation	SNP	G	G	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr1:204379825G>A	uc001hav.3	-	1	1120	c.715C>T	c.(715-717)CAG>TAG	p.Q239*		NM_032833	NP_116222	Q5SWA1	PR15B_HUMAN	protein phosphatase 1, regulatory subunit 15B	239					regulation of translation					ovary(1)|pancreas(1)	2	all_cancers(21;0.0032)|all_neural(3;0.0218)|Glioma(3;0.0382)|Breast(84;0.179)|all_epithelial(62;0.193)|Prostate(682;0.227)		all cancers(3;1.14e-29)|KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.139)			TCACTGTTCTGATAGCTGACT	0.507			NA											31	75					0	0	0.003755	0	0
NFASC	23114	broad.mit.edu	37	1	204938072	204938073	+	Missense_Mutation	DNP	TG	TG	AT			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	TG	TG	-	-	TG	TG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr1:204938072_204938073TG>AT	uc001hbj.2	+	10	1293_1294	c.965_966TG>AT	c.(964-966)ATG>AAT	p.M322N	NFASC_uc001hbh.2_Missense_Mutation_p.M322N|NFASC_uc010pqz.1_Missense_Mutation_p.M316N|NFASC_uc010pra.1_Missense_Mutation_p.M333N|NFASC_uc001hbi.2_Missense_Mutation_p.M333N|NFASC_uc009xbg.1_Missense_Mutation_p.M406N|NFASC_uc010prb.1_Missense_Mutation_p.M333N|NFASC_uc010prc.1_Translation_Start_Site|NFASC_uc001hbk.1_Missense_Mutation_p.M143N	NM_001005388	NP_001005388	O94856	NFASC_HUMAN	neurofascin isoform 1 precursor	322	Extracellular (Potential).|Ig-like C2-type 3.				axon guidance|cell adhesion|myelination|peripheral nervous system development	integral to membrane|node of Ranvier|plasma membrane	protein binding			ovary(3)|breast(1)|central_nervous_system(1)|skin(1)	6	all_cancers(21;0.0375)|Breast(84;0.0437)|all_epithelial(62;0.171)|Prostate(682;0.19)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.158)			TCCAACAAGATGGGCAGCATCC	0.48			NA											26	46					0	0	0.004672	0	0
CNTN2	6900	broad.mit.edu	37	1	205030523	205030523	+	Silent	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr1:205030523C>A	uc001hbr.2	+	8	1217	c.948C>A	c.(946-948)ACC>ACA	p.T316T	CNTN2_uc001hbq.1_Silent_p.T207T|CNTN2_uc009xbi.2_Silent_p.T207T|CNTN2_uc001hbs.2_Silent_p.T104T	NM_005076	NP_005067	Q02246	CNTN2_HUMAN	contactin 2 precursor	316	Ig-like C2-type 3.				axon guidance|clustering of voltage-gated potassium channels	anchored to membrane|juxtaparanode region of axon|myelin sheath|node of Ranvier|synapse part	identical protein binding			ovary(1)	1	all_cancers(21;0.144)|Breast(84;0.0437)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.158)			GCCGAGACACCGTGCAGGGCC	0.642	Melanoma(183;2548 2817 37099 41192)		NA									OREG0014144	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	14	9					0.000566183	0.000622257	0.00499	1	0
NUAK2	81788	broad.mit.edu	37	1	205272824	205272824	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr1:205272824G>T	uc001hce.2	-	7	1768	c.1641C>A	c.(1639-1641)AGC>AGA	p.S547R		NM_030952	NP_112214	Q9H093	NUAK2_HUMAN	NUAK family, SNF1-like kinase, 2	547					actin cytoskeleton organization|apoptosis|cellular response to glucose starvation|negative regulation of apoptosis		ATP binding|magnesium ion binding|protein serine/threonine kinase activity			ovary(3)|stomach(1)|breast(1)	5	Breast(84;0.186)		BRCA - Breast invasive adenocarcinoma(75;0.117)			AGGACAGGATGCTGTCCTCGC	0.682			NA											12	34					0.000308642	0.000341227	0.003163	1	0
CR1	1378	broad.mit.edu	37	1	207700188	207700188	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr1:207700188G>T	uc001hfy.2	+	6	1117	c.977G>T	c.(976-978)TGT>TTT	p.C326F	CR1_uc009xcl.1_Intron|CR1_uc001hfx.2_Missense_Mutation_p.C326F|CR1_uc009xcj.1_Intron|CR1_uc009xck.1_Missense_Mutation_p.C326F|CR1_uc010psh.1_5'Flank	NM_000573	NP_000564	P17927	CR1_HUMAN	complement receptor 1 isoform F precursor	326	Sushi 5.|Extracellular (Potential).				complement activation, classical pathway|innate immune response	integral to plasma membrane	complement receptor activity			ovary(3)	3						TTCTACAGCTGTGAGCCCGGC	0.587			NA											42	176					6.81593e-30	1.20802e-29	0.00361	1	0
CD34	947	broad.mit.edu	37	1	208072464	208072464	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr1:208072464G>T	uc001hgw.1	-	3	628	c.370C>A	c.(370-372)CCA>ACA	p.P124T	CD34_uc001hgx.1_Missense_Mutation_p.P124T|CD34_uc010psj.1_Intron	NM_001025109	NP_001020280	P28906	CD34_HUMAN	CD34 antigen isoform a	124	Extracellular (Potential).				cell-cell adhesion|leukocyte migration|regulation of immune response	integral to membrane	carbohydrate binding			ovary(1)	1						ACGTTGGCTGGGGTGGTGAAC	0.463			NA											46	183					4.0181e-32	7.19003e-32	0.00361	1	0
PLXNA2	5362	broad.mit.edu	37	1	208391011	208391011	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr1:208391011C>A	uc001hgz.2	-	2	1015	c.257G>T	c.(256-258)GGG>GTG	p.G86V	PLXNA2_uc001hha.3_Missense_Mutation_p.G140V	NM_025179	NP_079455	O75051	PLXA2_HUMAN	plexin A2 precursor	86	Extracellular (Potential).|Sema.				axon guidance	integral to membrane|intracellular|plasma membrane				ovary(2)|central_nervous_system(1)	3				OV - Ovarian serous cystadenocarcinoma(81;0.199)		CTCTTCTGGCCCTGTCTTATG	0.567			NA											39	39					1.02687e-29	1.81564e-29	0.003214	1	0
LAMB3	3914	broad.mit.edu	37	1	209791292	209791292	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr1:209791292G>A	uc001hhg.2	-	19	3401	c.3011C>T	c.(3010-3012)ACC>ATC	p.T1004I	LAMB3_uc009xco.2_Missense_Mutation_p.T1004I|LAMB3_uc001hhh.2_Missense_Mutation_p.T1004I	NM_001017402	NP_001017402	Q13751	LAMB3_HUMAN	laminin, beta 3 precursor	1004	Domain I.|Potential.				cell adhesion|epidermis development|hemidesmosome assembly		structural molecule activity			central_nervous_system(2)|skin(2)|large_intestine(1)|ovary(1)	6				OV - Ovarian serous cystadenocarcinoma(81;0.0519)		GGAGCGGCTGGTGCCTTGCAT	0.587			NA											27	98					0	0	0.002096	0	0
PTPN14	5784	broad.mit.edu	37	1	214557590	214557590	+	Silent	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr1:214557590C>A	uc001hkk.1	-	13	1879	c.1608G>T	c.(1606-1608)ACG>ACT	p.T536T	PTPN14_uc010pty.1_Silent_p.T437T	NM_005401	NP_005392	Q15678	PTN14_HUMAN	protein tyrosine phosphatase, non-receptor type	536					lymphangiogenesis	cytoplasm|cytoskeleton	protein tyrosine phosphatase activity|receptor tyrosine kinase binding			breast(2)|ovary(1)|kidney(1)|skin(1)	5				OV - Ovarian serous cystadenocarcinoma(81;0.00181)|all cancers(67;0.00194)|Epithelial(68;0.0157)|GBM - Glioblastoma multiforme(131;0.155)		GGGTGCTCACCGTGTGCGAGA	0.572	Colon(92;557 1424 24372 34121 40073)		NA											24	144					7.33532e-06	8.71216e-06	0.003954	1	0
KCTD3	51133	broad.mit.edu	37	1	215793784	215793784	+	Nonsense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr1:215793784G>T	uc001hks.2	+	18	2566	c.2272G>T	c.(2272-2274)GGA>TGA	p.G758*	KCTD3_uc001hkt.2_Nonsense_Mutation_p.G756*|KCTD3_uc010pub.1_Nonsense_Mutation_p.G656*|KCTD3_uc009xdn.2_Nonsense_Mutation_p.G482*	NM_016121	NP_057205	Q9Y597	KCTD3_HUMAN	potassium channel tetramerisation domain	758						voltage-gated potassium channel complex	protein binding|voltage-gated potassium channel activity			ovary(3)	3				all cancers(67;0.0164)|OV - Ovarian serous cystadenocarcinoma(81;0.019)|GBM - Glioblastoma multiforme(131;0.0862)|Epithelial(68;0.13)		GAAGAAAGGAGGATTTGAAGG	0.413			NA											19	76					8.10497e-08	1.03987e-07	0.010504	1	0
USH2A	7399	broad.mit.edu	37	1	215847863	215847863	+	Missense_Mutation	SNP	A	A	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr1:215847863A>T	uc001hku.1	-	63	13777	c.13390T>A	c.(13390-13392)TGG>AGG	p.W4464R		NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	4464	Fibronectin type-III 30.|Extracellular (Potential).				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		GGAGGTTTCCAGGTGATTTCT	0.453			NA								HNSCC(13;0.011)			36	105					0	0	0.00623	0	0
USH2A	7399	broad.mit.edu	37	1	216243462	216243462	+	Silent	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr1:216243462G>T	uc001hku.1	-	30	6417	c.6030C>A	c.(6028-6030)GTC>GTA	p.V2010V		NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	2010	Extracellular (Potential).|Fibronectin type-III 6.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		TGCTTGTATTGACAAATTCAG	0.408			NA								HNSCC(13;0.011)			21	61					7.07758e-08	9.1199e-08	0.004656	1	0
USH2A	7399	broad.mit.edu	37	1	216258067	216258067	+	Missense_Mutation	SNP	T	T	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr1:216258067T>A	uc001hku.1	-	25	5527	c.5140A>T	c.(5140-5142)AAT>TAT	p.N1714Y		NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	1714	Laminin G-like 2.|Extracellular (Potential).				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		GCTCCCTCATTTAATGAAGCG	0.403			NA								HNSCC(13;0.011)			12	83					0	0	0.003163	0	0
USH2A	7399	broad.mit.edu	37	1	216595579	216595579	+	Silent	SNP	G	G	T	rs141672841	by1000genomes	TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr1:216595579G>T	uc001hku.1	-	2	487	c.100C>A	c.(100-102)CGA>AGA	p.R34R	USH2A_uc001hkv.2_Silent_p.R34R	NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	34	Extracellular (Potential).				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		AAAAGACCTCGTGACTCAGTC	0.458			NA								HNSCC(13;0.011)			18	65					1.37522e-17	2.22762e-17	0.007413	1	0
SPATA17	128153	broad.mit.edu	37	1	217822223	217822223	+	Splice_Site	SNP	G	G	C			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr1:217822223G>C	uc001hlh.1	+	2	95	c.69_splice	c.e2-1	p.S23_splice	SPATA17_uc009xdr.1_Splice_Site|SPATA17_uc001hli.2_Splice_Site_p.S23_splice	NM_138796	NP_620151	Q96L03	SPT17_HUMAN	spermatogenesis associated 17							cytoplasm	calmodulin binding			pancreas(1)	1				OV - Ovarian serous cystadenocarcinoma(81;0.0516)|all cancers(67;0.0891)|GBM - Glioblastoma multiforme(131;0.117)		TTTTGTTTTAGTGTTGTAGAT	0.308			NA											12	64					0	0	0.001855	0	0
RAB3GAP2	25782	broad.mit.edu	37	1	220379258	220379258	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr1:220379258C>A	uc010puk.1	-	8	867	c.703G>T	c.(703-705)GTA>TTA	p.V235L	RAB3GAP2_uc001hmf.2_RNA|RAB3GAP2_uc001hmg.2_5'UTR	NM_012414	NP_036546	Q9H2M9	RBGPR_HUMAN	rab3 GTPase-activating protein, non-catalytic	235					intracellular protein transport	cytoplasm|soluble fraction	GTPase activator activity|protein heterodimerization activity			central_nervous_system(1)	1				GBM - Glioblastoma multiforme(131;0.0443)		CCTTTTGCTACCTGATTTCGA	0.308			NA											20	14					1.96895e-08	2.58414e-08	0.00278	1	0
MARK1	4139	broad.mit.edu	37	1	220835440	220835440	+	Nonsense_Mutation	SNP	C	C	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr1:220835440C>T	uc001hmn.3	+	18	2917	c.2320C>T	c.(2320-2322)CGA>TGA	p.R774*	MARK1_uc009xdw.2_Nonsense_Mutation_p.R775*|MARK1_uc010pun.1_Nonsense_Mutation_p.R759*|MARK1_uc001hmm.3_Nonsense_Mutation_p.R737*	NM_018650	NP_061120	Q9P0L2	MARK1_HUMAN	MAP/microtubule affinity-regulating kinase 1	774	KA1.				intracellular protein kinase cascade	cytoplasm|microtubule cytoskeleton	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			ovary(4)|central_nervous_system(2)|skin(2)|stomach(1)|lung(1)	10				GBM - Glioblastoma multiforme(131;0.0407)		TCGCTTCAAGCGAATATCTGG	0.438			NA											32	33					0	0	0.004878	0	0
HLX	3142	broad.mit.edu	37	1	221057824	221057824	+	Silent	SNP	C	C	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr1:221057824C>T	uc001hmv.3	+	4	1702	c.1245C>T	c.(1243-1245)CTC>CTT	p.L415L		NM_021958	NP_068777	Q14774	HLX_HUMAN	H2.0-like homeobox	415	Ser-rich.				cell differentiation	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(2)	2				GBM - Glioblastoma multiforme(131;0.00914)		CTGGCGCCCTCATTACCGCca	0.333			NA											5	11					0	0	0.001168	0	0
NID1	4811	broad.mit.edu	37	1	236205319	236205319	+	Silent	SNP	G	G	C			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr1:236205319G>C	uc001hxo.2	-	4	1128	c.1026C>G	c.(1024-1026)CCC>CCG	p.P342P	NID1_uc009xgd.2_Silent_p.P342P	NM_002508	NP_002499	P14543	NID1_HUMAN	nidogen 1 precursor	342					cell-matrix adhesion	basement membrane	calcium ion binding			large_intestine(1)|pancreas(1)	2	Ovarian(103;0.0544)|Breast(184;0.23)	all_cancers(173;0.00491)|Prostate(94;0.184)|Acute lymphoblastic leukemia(190;0.229)	OV - Ovarian serous cystadenocarcinoma(106;0.00162)		Becaplermin(DB00102)|Urokinase(DB00013)	GAGGTCCAAGGGGCCTTTCGG	0.582			NA											30	24					0	0	0.003271	0	0
ACTN2	88	broad.mit.edu	37	1	236907948	236907948	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr1:236907948G>T	uc001hyf.2	+	12	1482	c.1278G>T	c.(1276-1278)CAG>CAT	p.Q426H	ACTN2_uc001hyg.2_Missense_Mutation_p.Q218H|ACTN2_uc009xgi.1_Missense_Mutation_p.Q426H|ACTN2_uc010pxu.1_Missense_Mutation_p.Q115H|ACTN2_uc001hyh.2_Missense_Mutation_p.Q114H	NM_001103	NP_001094	P35609	ACTN2_HUMAN	actinin, alpha 2	426	Spectrin 2.				focal adhesion assembly|microspike assembly|muscle filament sliding|platelet activation|platelet degranulation|protein homotetramerization|regulation of apoptosis|synaptic transmission	actin filament|cytosol|dendritic spine|extracellular region|filopodium|focal adhesion|nucleolus|platelet alpha granule lumen|pseudopodium|Z disc	actin binding|calcium ion binding|FATZ 1 binding|identical protein binding|integrin binding|protein dimerization activity|structural constituent of muscle|titin binding|titin Z domain binding|ZASP binding			ovary(4)|skin(1)	5	Ovarian(103;0.0634)|Breast(184;0.221)	all_cancers(173;0.00661)|Acute lymphoblastic leukemia(190;0.109)|Prostate(94;0.174)	OV - Ovarian serous cystadenocarcinoma(106;0.00168)			TCTTGCTGCAGAAGGATTACG	0.597			NA											18	14					6.33239e-15	9.74768e-15	0.010504	1	0
RYR2	6262	broad.mit.edu	37	1	237756790	237756790	+	Silent	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr1:237756790G>T	uc001hyl.1	+	33	4410	c.4290G>T	c.(4288-4290)GTG>GTT	p.V1430V		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	1430	Cytoplasmic (By similarity).|B30.2/SPRY 3.|4 X approximate repeats.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			ATTACTCAGTGAGAATCTTTC	0.398			NA											26	20					4.74835e-14	7.16833e-14	0.002096	1	0
FMN2	56776	broad.mit.edu	37	1	240255893	240255893	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr1:240255893G>T	uc010pyd.1	+	1	709	c.484G>T	c.(484-486)GAT>TAT	p.D162Y	FMN2_uc010pye.1_Missense_Mutation_p.D162Y	NM_020066	NP_064450	Q9NZ56	FMN2_HUMAN	formin 2	162					actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			ovary(4)|pancreas(3)|skin(3)|large_intestine(1)|central_nervous_system(1)	12	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			GATCGCCGAGGATGTGGAAAC	0.642			NA											22	13					1.37878e-21	2.32718e-21	0.00333	1	0
SMYD3	64754	broad.mit.edu	37	1	246093203	246093203	+	Missense_Mutation	SNP	T	T	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr1:246093203T>A	uc001ibl.2	-	6	663	c.568A>T	c.(568-570)ATG>TTG	p.M190L	SMYD3_uc001ibk.2_Missense_Mutation_p.M131L|SMYD3_uc001ibi.2_Missense_Mutation_p.M1L|SMYD3_uc001ibj.2_Missense_Mutation_p.M1L	NM_022743	NP_073580	Q9H7B4	SMYD3_HUMAN	SET and MYND domain containing 3	190	SET.					cytoplasm|nucleus	histone-lysine N-methyltransferase activity|protein binding|zinc ion binding				0	all_cancers(71;0.000291)|all_epithelial(71;0.000174)|Ovarian(71;0.0377)|all_lung(81;0.0568)|Lung NSC(105;0.0804)|Breast(184;0.173)|Melanoma(84;0.242)	all_cancers(173;0.0496)|Acute lymphoblastic leukemia(190;0.164)	OV - Ovarian serous cystadenocarcinoma(106;0.0129)	all cancers(4;0.028)|GBM - Glioblastoma multiforme(49;0.0537)		ACTTCCTGCATCTCCGCATTA	0.453			NA											41	59					0	0	0.00361	0	0
OR13G1	441933	broad.mit.edu	37	1	247835510	247835510	+	Silent	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr1:247835510C>A	uc001idi.1	-	1	834	c.834G>T	c.(832-834)GTG>GTT	p.V278V		NM_001005487	NP_001005487	Q8NGZ3	O13G1_HUMAN	olfactory receptor, family 13, subfamily G,	278	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.017)			ATGTGGGAGTCACAAGAGTAT	0.438			NA											50	37					2.76378e-25	4.80111e-25	0.00361	1	0
OR2L3	391192	broad.mit.edu	37	1	248224661	248224661	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr1:248224661C>A	uc001idx.1	+	1	678	c.678C>A	c.(676-678)CAC>CAA	p.H226Q	OR2L13_uc001ids.2_Intron	NM_001004687	NP_001004687	Q8NG85	OR2L3_HUMAN	olfactory receptor, family 2, subfamily L,	226	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0278)			CTGTCTACCACATGAAATCTG	0.463			NA											37	100					6.18754e-15	9.53459e-15	0.00361	1	0
OR2M2	391194	broad.mit.edu	37	1	248343895	248343895	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr1:248343895G>T	uc010pzf.1	+	1	608	c.608G>T	c.(607-609)TGT>TTT	p.C203F		NM_001004688	NP_001004688	Q96R28	OR2M2_HUMAN	olfactory receptor, family 2, subfamily M,	203	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(3)|skin(1)	4	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			TTCATCTGCTGTATAGTAATG	0.428			NA											173	107					1.5993e-79	2.99894e-79	0.00361	1	0
OR2M3	127062	broad.mit.edu	37	1	248366543	248366543	+	Silent	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr1:248366543C>A	uc010pzg.1	+	1	174	c.174C>A	c.(172-174)CCC>CCA	p.P58P		NM_001004689	NP_001004689	Q8NG83	OR2M3_HUMAN	olfactory receptor, family 2, subfamily M,	58	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			TCCACACCCCCATGTACCTCC	0.547			NA											195	146					2.57275e-87	4.84876e-87	0.00361	1	0
OR2M7	391196	broad.mit.edu	37	1	248487649	248487649	+	Silent	SNP	G	G	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr1:248487649G>A	uc010pzk.1	-	1	222	c.222C>T	c.(220-222)ATC>ATT	p.I74I		NM_001004691	NP_001004691	Q8NG81	OR2M7_HUMAN	olfactory receptor, family 2, subfamily M,	74	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			CAGTGGTGCAGATGAGCATGA	0.493			NA											169	135					0	0	0.00361	0	0
TUBB8	347688	broad.mit.edu	37	10	94620	94620	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr10:94620C>A	uc001ifi.2	-	3	212	c.212G>T	c.(211-213)GGC>GTC	p.G71V	TUBB8_uc009xhe.2_Intron|TUBB8_uc010pzs.1_5'UTR	NM_177987	NP_817124	Q3ZCM7	TBB8_HUMAN	tubulin, beta 8 isoform 1	71					microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|structural molecule activity			ovary(1)	1		all_cancers(4;0.00131)|all_lung(4;0.000777)|Lung NSC(4;0.0043)|all_epithelial(10;0.0154)|Colorectal(49;0.235)		Epithelial(11;0.00341)|all cancers(11;0.00922)|OV - Ovarian serous cystadenocarcinoma(14;0.0508)|Lung(33;0.132)		GTCCATGGTGCCCGGCTCCAG	0.701	Pancreas(192;2041 3010 9013 18103)		NA											20	41					1.42536e-11	2.05378e-11	0.004656	1	0
TAF3	83860	broad.mit.edu	37	10	8006747	8006747	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr10:8006747G>T	uc010qbd.1	+	3	1274	c.1274G>T	c.(1273-1275)AGA>ATA	p.R425I		NM_031923	NP_114129	Q5VWG9	TAF3_HUMAN	RNA polymerase II transcription factor TAFII140	425					maintenance of protein location in nucleus|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	transcription factor TFIID complex	protein binding|zinc ion binding			ovary(1)	1						AGCCCTAAGAGAATTTCAGGC	0.493			NA											30	54					5.43694e-19	8.94328e-19	0.005524	1	0
FRMD4A	55691	broad.mit.edu	37	10	13735910	13735910	+	Silent	SNP	G	G	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr10:13735910G>A	uc001ims.2	-	15	1457	c.1105C>T	c.(1105-1107)CTG>TTG	p.L369L	FRMD4A_uc009xjf.1_Silent_p.L369L|FRMD4A_uc001imt.1_Silent_p.L402L|FRMD4A_uc001imu.1_Silent_p.L385L	NM_018027	NP_060497	Q9P2Q2	FRM4A_HUMAN	FERM domain containing 4A	369						cytoplasm|cytoskeleton	binding			ovary(1)|skin(1)|pancreas(1)	3						GAAGACAGCAGGCTGCCGCTG	0.652			NA											12	18					0	0	0.001855	0	0
FAM171A1	221061	broad.mit.edu	37	10	15317910	15317910	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr10:15317910C>A	uc001iob.2	-	3	369	c.362G>T	c.(361-363)CGC>CTC	p.R121L		NM_001010924	NP_001010924	Q5VUB5	F1711_HUMAN	hypothetical protein LOC221061 precursor	121	Extracellular (Potential).					integral to membrane				ovary(2)|breast(1)|skin(1)	4						AGTGGCAGAGCGTTCTGGAAG	0.333			NA											8	39					2.27111e-07	2.85232e-07	0.001368	1	0
ITGA8	8516	broad.mit.edu	37	10	15760770	15760770	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr10:15760770G>C	uc001ioc.1	-	2	338	c.338C>G	c.(337-339)ACC>AGC	p.T113S	ITGA8_uc010qcb.1_Missense_Mutation_p.T113S	NM_003638	NP_003629	P53708	ITA8_HUMAN	integrin, alpha 8 precursor	113	Extracellular (Potential).				cell differentiation|cell-cell adhesion|cell-matrix adhesion|integrin-mediated signaling pathway|nervous system development	integrin complex	receptor activity			ovary(3)|lung(3)	6						CTTACTGGTGGTGTCAAACGG	0.597			NA											19	93					0	0	0.008871	0	0
GPR158	57512	broad.mit.edu	37	10	25883266	25883266	+	Silent	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr10:25883266G>T	uc001isj.2	+	9	1998	c.1938G>T	c.(1936-1938)CTG>CTT	p.L646L	GPR158_uc001isk.2_Silent_p.L21L	NM_020752	NP_065803	Q5T848	GP158_HUMAN	G protein-coupled receptor 158 precursor	646	Helical; Name=7; (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(4)|large_intestine(2)|pancreas(1)|skin(1)	8						TGTTGATGCTGTATTTTGCAC	0.323			NA											26	55					5.91797e-21	9.9323e-21	0.002445	1	0
MYO3A	53904	broad.mit.edu	37	10	26417319	26417319	+	Splice_Site	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr10:26417319G>T	uc001isn.2	+	20	2475	c.2115_splice	c.e20-1	p.S705_splice	MYO3A_uc009xko.1_Splice_Site_p.S705_splice|MYO3A_uc009xkp.1_Splice_Site|MYO3A_uc009xkq.1_Intron	NM_017433	NP_059129	Q8NEV4	MYO3A_HUMAN	myosin IIIA						protein autophosphorylation|response to stimulus|sensory perception of sound|visual perception	cytoplasm|filamentous actin|filopodium|myosin complex	actin binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|plus-end directed microfilament motor activity|protein serine/threonine kinase activity			ovary(6)|stomach(3)|lung(3)|central_nervous_system(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	18						AATTCTTCTAGTGGGAATGGT	0.353			NA											6	45					1.12685e-05	1.32356e-05	0.004482	1	0
SVIL	6840	broad.mit.edu	37	10	29812817	29812817	+	Missense_Mutation	SNP	T	T	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr10:29812817T>A	uc001iut.1	-	15	3479	c.2726A>T	c.(2725-2727)TAT>TTT	p.Y909F	SVIL_uc010qdw.1_5'Flank|SVIL_uc001iuu.1_Missense_Mutation_p.Y483F	NM_021738	NP_068506	O95425	SVIL_HUMAN	supervillin isoform 2	909					cytoskeleton organization|skeletal muscle tissue development	cell junction|costamere|invadopodium|nucleus|podosome	actin filament binding			ovary(5)|upper_aerodigestive_tract(1)	6		Breast(68;0.103)				AGAAAACTTATAGTCAGTGGC	0.468			NA											9	46					0	0	0.006214	0	0
ARHGAP12	94134	broad.mit.edu	37	10	32150432	32150432	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr10:32150432C>G	uc001ivz.1	-	4	1109	c.839G>C	c.(838-840)CGT>CCT	p.R280P	ARHGAP12_uc001ivy.1_Missense_Mutation_p.R278P|ARHGAP12_uc009xls.2_Missense_Mutation_p.R278P|ARHGAP12_uc001iwb.1_Missense_Mutation_p.R278P|ARHGAP12_uc001iwc.1_Missense_Mutation_p.R278P|ARHGAP12_uc009xlq.1_Missense_Mutation_p.R278P|ARHGAP12_uc001iwd.1_Missense_Mutation_p.R278P|ARHGAP12_uc009xlr.1_Missense_Mutation_p.R278P	NM_018287	NP_060757	Q8IWW6	RHG12_HUMAN	Rho GTPase activating protein 12	280	WW 1.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity				0		Prostate(175;0.0199)				GTAATAGCAACGCCCTGAGCT	0.478			NA											6	22					0	0	0.001168	0	0
NRP1	8829	broad.mit.edu	37	10	33486617	33486617	+	Missense_Mutation	SNP	T	T	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr10:33486617T>A	uc001iwx.3	-	12	2408	c.1885A>T	c.(1885-1887)ACA>TCA	p.T629S	NRP1_uc001iwv.3_Missense_Mutation_p.T629S|NRP1_uc009xlz.2_Missense_Mutation_p.T622S|NRP1_uc001iww.3_Missense_Mutation_p.T441S|NRP1_uc001iwy.3_Missense_Mutation_p.T622S|NRP1_uc001iwz.2_Missense_Mutation_p.T629S|NRP1_uc001ixa.2_Missense_Mutation_p.T594S	NM_003873	NP_003864	O14786	NRP1_HUMAN	neuropilin 1 isoform a	629	Extracellular (Potential).				axon guidance|cell adhesion|cell-cell signaling|organ morphogenesis|positive regulation of cell proliferation	extracellular region|integral to membrane|plasma membrane	growth factor binding|heparin binding|metal ion binding|vascular endothelial growth factor receptor activity			central_nervous_system(2)|ovary(1)|skin(1)	4					Palifermin(DB00039)|Pegaptanib(DB04895)	GGCTTTTCTGTGGCCAGCACA	0.423	Melanoma(104;886 1489 44640 45944 51153)		NA											8	28					0	0	0.004482	0	0
LRRC18	474354	broad.mit.edu	37	10	50121979	50121979	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr10:50121979G>T	uc001jhd.2	-	1	302	c.222C>A	c.(220-222)AAC>AAA	p.N74K	WDFY4_uc001jha.3_Intron|LRRC18_uc001jhe.1_Missense_Mutation_p.N74K	NM_001006939	NP_001006940	Q8N456	LRC18_HUMAN	leucine rich repeat containing 18	74	LRR 3.					cytoplasm				ovary(1)|pancreas(1)	2						GCCACCGGAGGTTCTGGAACT	0.547			NA											4	37					0.00024832	0.000277424	0.009096	1	0
DRGX	644168	broad.mit.edu	37	10	50574416	50574416	+	Silent	SNP	C	C	G			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr10:50574416C>G	uc010qgq.1	-	6	552	c.552G>C	c.(550-552)CTG>CTC	p.L184L		NM_001080520	NP_001073989	A6NNA5	DRGX_HUMAN	dorsal root ganglia homeobox	184					multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						AGCAAGAGCACAGTGGGCCCC	0.587			NA											7	25					0	0	0.00308	0	0
CHAT	1103	broad.mit.edu	37	10	50827924	50827924	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr10:50827924C>A	uc001jhz.2	+	3	694	c.541C>A	c.(541-543)CAG>AAG	p.Q181K	CHAT_uc001jhv.1_Missense_Mutation_p.Q63K|CHAT_uc001jhx.1_Missense_Mutation_p.Q63K|CHAT_uc001jhy.1_Missense_Mutation_p.Q63K|CHAT_uc001jia.2_Missense_Mutation_p.Q63K|CHAT_uc010qgs.1_Missense_Mutation_p.Q63K	NM_020549	NP_065574	P28329	CLAT_HUMAN	choline acetyltransferase isoform 2	181					neurotransmitter biosynthetic process|neurotransmitter secretion	cytosol|nucleus	choline O-acetyltransferase activity			central_nervous_system(3)	3		all_neural(218;0.107)		GBM - Glioblastoma multiforme(2;0.000585)	Choline(DB00122)	GACCCTGCAGCAGAAACTCCT	0.617			NA											4	11					1.23904e-05	1.44506e-05	0.000602	1	0
PRKG1	5592	broad.mit.edu	37	10	54053613	54053613	+	Missense_Mutation	SNP	G	G	T	rs142375882		TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr10:54053613G>T	uc001jjm.2	+	18	2163	c.1969G>T	c.(1969-1971)GAT>TAT	p.D657Y	PRKG1_uc001jjo.2_Missense_Mutation_p.D672Y|PRKG1_uc009xow.1_Missense_Mutation_p.D375Y|uc001jjq.1_Intron	NM_001098512	NP_001091982	Q13976	KGP1_HUMAN	protein kinase, cGMP-dependent, type I isoform	657	AGC-kinase C-terminal.				actin cytoskeleton organization|platelet activation|signal transduction	cytosol	ATP binding|cGMP binding|cGMP-dependent protein kinase activity			lung(2)|stomach(1)|ovary(1)|central_nervous_system(1)|skin(1)	6		all_cancers(4;2.13e-08)|all_epithelial(4;2.44e-08)|all_lung(4;0.000173)		all cancers(4;1.18e-05)|GBM - Glioblastoma multiforme(4;0.000359)|Epithelial(53;0.00532)|Lung(62;0.0606)		TGAGGACAACGATGAACCACC	0.398			NA											20	41					1.85244e-09	2.5179e-09	0.00333	1	0
MBL2	4153	broad.mit.edu	37	10	54531325	54531325	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr10:54531325G>T	uc001jjt.2	-	1	136	c.71C>A	c.(70-72)ACC>AAC	p.T24N		NM_000242	NP_000233	P11226	MBL2_HUMAN	soluble mannose-binding lectin precursor	24	Cys-rich.		T -> A (in Chinese).		acute-phase response|complement activation, classical pathway|complement activation, lectin pathway|defense response to Gram-positive bacterium|negative regulation of growth of symbiont in host|opsonization|response to oxidative stress	collagen|extracellular space	bacterial cell surface binding|calcium-dependent protein binding|eukaryotic cell surface binding|mannose binding|receptor binding			ovary(1)	1						ATCCTCACAGGTCACAGTTTC	0.547			NA											12	14					7.93312e-07	9.78967e-07	0.00245	1	0
PCDH15	65217	broad.mit.edu	37	10	55566680	55566680	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr10:55566680G>T	uc010qhq.1	-	36	5103	c.4708C>A	c.(4708-4710)CCT>ACT	p.P1570T	PCDH15_uc010qhr.1_Missense_Mutation_p.P1565T	NM_001142771	NP_001136243	Q96QU1	PCD15_HUMAN	protocadherin 15 isoform CD3-1 precursor	423	Cadherin 4.|Extracellular (Potential).				equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			pancreas(5)|ovary(4)|upper_aerodigestive_tract(2)|skin(2)	13		Melanoma(3;0.117)|Lung SC(717;0.238)				AGTCGAACAGGGGAAGCAACT	0.458			NA								HNSCC(58;0.16)			28	52					5.77227e-19	9.48438e-19	0.008361	1	0
BICC1	80114	broad.mit.edu	37	10	60573602	60573602	+	Missense_Mutation	SNP	T	T	C			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr10:60573602T>C	uc001jki.1	+	18	2389	c.2389T>C	c.(2389-2391)TCC>CCC	p.S797P	BICC1_uc001jkj.1_Missense_Mutation_p.S438P	NM_001080512	NP_001073981	Q9H694	BICC1_HUMAN	bicaudal C homolog 1	797					multicellular organismal development		RNA binding			ovary(2)|lung(1)|skin(1)	4						CTCATCCATGTCCCTTTCACG	0.458			NA											29	71					0	0	0.004289	0	0
HKDC1	80201	broad.mit.edu	37	10	71020921	71020921	+	Missense_Mutation	SNP	A	A	C			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr10:71020921A>C	uc001jpf.3	+	16	2376	c.2243A>C	c.(2242-2244)TAC>TCC	p.Y748S	HKDC1_uc010qje.1_Missense_Mutation_p.Y611S|HKDC1_uc009xqb.2_RNA	NM_025130	NP_079406	Q2TB90	HKDC1_HUMAN	hexokinase domain containing 1	748					glycolysis	mitochondrion|nucleus	ATP binding|hexokinase activity			ovary(4)|skin(1)	5						AGTGGGATGTACTTGGGGGAG	0.458			NA											9	38					0	0	0.008291	0	0
NUDT13	25961	broad.mit.edu	37	10	74890529	74890529	+	Silent	SNP	G	G	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr10:74890529G>A	uc001jtj.2	+	9	1052	c.927G>A	c.(925-927)CTG>CTA	p.L309L	NUDT13_uc010qkc.1_Silent_p.L183L|NUDT13_uc010qkd.1_Silent_p.L112L|NUDT13_uc009xqw.2_RNA|NUDT13_uc001jtk.2_3'UTR|NUDT13_uc010qke.1_Silent_p.L112L|NUDT13_uc001jtl.2_Silent_p.L220L	NM_015901	NP_056985	Q86X67	NUD13_HUMAN	nudix-type motif 13	309	Nudix hydrolase.						hydrolase activity|metal ion binding				0	Prostate(51;0.0119)					CCACAGCCCTGAAGAGAAAGG	0.493			NA											3	27					0	0	0.004672	0	0
KCNMA1	3778	broad.mit.edu	37	10	78868308	78868308	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr10:78868308G>T	uc001jxn.2	-	9	1331	c.1154C>A	c.(1153-1155)CCT>CAT	p.P385H	KCNMA1_uc001jxj.2_Missense_Mutation_p.P385H|KCNMA1_uc001jxk.1_Intron|KCNMA1_uc009xrt.1_Missense_Mutation_p.P205H|KCNMA1_uc001jxl.1_Missense_Mutation_p.P39H|KCNMA1_uc001jxo.2_Missense_Mutation_p.P385H|KCNMA1_uc001jxm.2_Missense_Mutation_p.P385H|KCNMA1_uc001jxq.2_Missense_Mutation_p.P385H	NM_001161352	NP_001154824	Q12791	KCMA1_HUMAN	large conductance calcium-activated potassium	385	Helical; Name=Segment S6; (Potential).				cellular potassium ion homeostasis|negative regulation of cell volume|platelet activation|positive regulation of apoptosis|regulation of membrane potential|response to calcium ion|response to carbon monoxide|response to hypoxia|response to osmotic stress|smooth muscle contraction involved in micturition	apical plasma membrane|caveola|integral to membrane|voltage-gated potassium channel complex	actin binding|calcium-activated potassium channel activity|large conductance calcium-activated potassium channel activity|metal ion binding|voltage-gated potassium channel activity			pancreas(2)|ovary(1)	3	all_cancers(46;0.203)|all_epithelial(25;0.00604)|Prostate(51;0.0198)		OV - Ovarian serous cystadenocarcinoma(4;0.0586)|Epithelial(14;0.081)|all cancers(16;0.183)		Bendroflumethiazide(DB00436)|Benzthiazide(DB00562)|Chlorothiazide(DB00880)|Chlorzoxazone(DB00356)|Cromoglicate(DB01003)|Cyclothiazide(DB00606)|Diazoxide(DB01119)|Enflurane(DB00228)|Hydrochlorothiazide(DB00999)|Hydroflumethiazide(DB00774)|Methyclothiazide(DB00232)|Quinethazone(DB01325)|Trichlormethiazide(DB01021)	TATGATTTCAGGGACGTAGCT	0.488			NA											21	37					1.10513e-12	1.63842e-12	0.002299	1	0
DLG5	9231	broad.mit.edu	37	10	79576327	79576327	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr10:79576327C>A	uc001jzk.2	-	20	4077	c.4007G>T	c.(4006-4008)GGG>GTG	p.G1336V	DLG5_uc001jzi.2_Missense_Mutation_p.G91V|DLG5_uc001jzj.2_Missense_Mutation_p.G751V|DLG5_uc009xru.1_RNA|DLG5_uc001jzl.3_Missense_Mutation_p.G940V	NM_004747	NP_004738	Q8TDM6	DLG5_HUMAN	discs large homolog 5	1336					cell-cell adhesion|intracellular signal transduction|negative regulation of cell proliferation|regulation of apoptosis	cell junction|cytoplasm	beta-catenin binding|cytoskeletal protein binding|receptor signaling complex scaffold activity			ovary(5)|breast(3)	8	all_cancers(46;0.0316)|all_epithelial(25;0.00147)|Breast(12;0.0015)|Prostate(51;0.0146)		Epithelial(14;0.00105)|OV - Ovarian serous cystadenocarcinoma(4;0.00151)|all cancers(16;0.00446)			TCTCCGCTCCCCGAGGGACGC	0.627			NA											27	83					8.88839e-20	1.46856e-19	0.002096	1	0
DLG5	9231	broad.mit.edu	37	10	79613233	79613233	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr10:79613233C>A	uc001jzk.2	-	5	813	c.743G>T	c.(742-744)AGG>ATG	p.R248M	DLG5_uc001jzj.2_Missense_Mutation_p.R3M|DLG5_uc009xru.1_RNA	NM_004747	NP_004738	Q8TDM6	DLG5_HUMAN	discs large homolog 5	248					cell-cell adhesion|intracellular signal transduction|negative regulation of cell proliferation|regulation of apoptosis	cell junction|cytoplasm	beta-catenin binding|cytoskeletal protein binding|receptor signaling complex scaffold activity			ovary(5)|breast(3)	8	all_cancers(46;0.0316)|all_epithelial(25;0.00147)|Breast(12;0.0015)|Prostate(51;0.0146)		Epithelial(14;0.00105)|OV - Ovarian serous cystadenocarcinoma(4;0.00151)|all cancers(16;0.00446)			ATTCTCCCGCCTCAGCATGTC	0.617			NA											6	18					0.000274275	0.000304364	0.004482	1	0
ANXA11	311	broad.mit.edu	37	10	81930597	81930597	+	Missense_Mutation	SNP	T	T	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr10:81930597T>A	uc001kbq.1	-	5	955	c.130A>T	c.(130-132)ACC>TCC	p.T44S	ANXA11_uc010qlx.1_Missense_Mutation_p.T144S|ANXA11_uc001kbr.1_Missense_Mutation_p.T44S|ANXA11_uc001kbs.1_Missense_Mutation_p.T44S|ANXA11_uc001kbt.1_Missense_Mutation_p.T44S|ANXA11_uc010qly.1_Missense_Mutation_p.T11S|ANXA11_uc009xsq.1_Missense_Mutation_p.T44S|ANXA11_uc001kbu.1_Missense_Mutation_p.T44S	NM_145869	NP_665876	P50995	ANX11_HUMAN	annexin A11	44					cell cycle|cytokinesis, completion of separation|phagocytosis|response to calcium ion	azurophil granule|melanosome|midbody|nuclear envelope|nucleoplasm|phagocytic vesicle|specific granule|spindle	calcium-dependent phospholipid binding|calcium-dependent protein binding|S100 alpha binding			ovary(1)	1	Prostate(51;0.00985)|all_epithelial(25;0.0951)		Colorectal(32;0.109)			CCCGCATAGGTGGCCACGTTA	0.632			NA											22	56					0	0	0.00333	0	0
MMRN2	79812	broad.mit.edu	37	10	88696877	88696877	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr10:88696877G>T	uc001kea.2	-	7	2600	c.2473C>A	c.(2473-2475)CCT>ACT	p.P825T	MMRN2_uc010qmn.1_Missense_Mutation_p.P468T	NM_024756	NP_079032	Q9H8L6	MMRN2_HUMAN	multimerin 2 precursor	825	C1q.					extracellular space				large_intestine(1)	1						AAGGCCACAGGGGATCCTGAA	0.488			NA											5	21					3.59834e-05	4.13823e-05	0.001168	1	0
SLC16A12	387700	broad.mit.edu	37	10	91222194	91222194	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr10:91222194C>A	uc001kgm.2	-	3	443	c.52G>T	c.(52-54)GGC>TGC	p.G18C		NM_213606	NP_998771	Q6ZSM3	MOT12_HUMAN	solute carrier family 16 (monocarboxylic acid	18	Extracellular (Potential).					integral to membrane|plasma membrane	symporter activity			skin(1)	1						ATCATCCAGCCCCAGCCTCCA	0.468			NA											32	87					2.19358e-23	3.75789e-23	0.005524	1	0
KIF20B	9585	broad.mit.edu	37	10	91497935	91497935	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr10:91497935C>G	uc001kgs.1	+	20	3409	c.3337C>G	c.(3337-3339)CTA>GTA	p.L1113V	KIF20B_uc001kgr.1_Missense_Mutation_p.L1073V|KIF20B_uc001kgt.1_Missense_Mutation_p.L324V|KIF20B_uc009xtw.1_RNA	NM_016195	NP_057279	Q96Q89	KI20B_HUMAN	M-phase phosphoprotein 1	1113					cell cycle arrest|cell division|microtubule-based movement|mitosis|regulation of mitosis	centrosome|microtubule|nucleolus|nucleoplasm|spindle	ATP binding|ATPase activity|microtubule motor activity|WW domain binding			ovary(1)|pancreas(1)|skin(1)	3						CCAAGATGACCTACTAAAAGA	0.333			NA											11	26					0	0	0.000978	0	0
HTR7	3363	broad.mit.edu	37	10	92508793	92508793	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr10:92508793C>A	uc001kha.2	-	2	1341	c.1098G>T	c.(1096-1098)GAG>GAT	p.E366D	HTR7_uc001kgz.2_Missense_Mutation_p.E366D|HTR7_uc001khb.2_Missense_Mutation_p.E366D	NM_019859	NP_062873	P34969	5HT7R_HUMAN	5-hydroxytryptamine receptor 7 isoform d	366	Extracellular (By similarity).				blood circulation|circadian rhythm	integral to plasma membrane	protein binding|serotonin receptor activity			ovary(1)	1					Eletriptan(DB00216)|Methysergide(DB00247)|Ziprasidone(DB00246)	GAAATGTCCTCTCCACCCACA	0.542			NA											23	77					6.32553e-13	9.41548e-13	0.004656	1	0
PLCE1	51196	broad.mit.edu	37	10	96058414	96058414	+	Missense_Mutation	SNP	T	T	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr10:96058414T>A	uc001kjk.2	+	24	6080	c.5446T>A	c.(5446-5448)TAC>AAC	p.Y1816N	PLCE1_uc010qnx.1_Missense_Mutation_p.Y1800N|PLCE1_uc001kjm.2_Missense_Mutation_p.Y1508N|PLCE1_uc001kjp.2_Missense_Mutation_p.Y174N	NM_016341	NP_057425	Q9P212	PLCE1_HUMAN	phospholipase C, epsilon 1 isoform 1	1816	PI-PLC Y-box.				activation of MAPK activity|activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|calcium-mediated signaling|cell proliferation|cytoskeleton organization|diacylglycerol biosynthetic process|elevation of cytosolic calcium ion concentration|epidermal growth factor receptor signaling pathway|glomerulus development|heart development|lipid catabolic process|Ras protein signal transduction|regulation of cell growth|regulation of G-protein coupled receptor protein signaling pathway|regulation of Ras protein signal transduction|regulation of smooth muscle contraction	cytosol|Golgi membrane|membrane fraction|plasma membrane	calcium ion binding|guanyl-nucleotide exchange factor activity|phosphatidylinositol phospholipase C activity|Ras GTPase binding|receptor signaling protein activity			ovary(2)|skin(1)	3		Colorectal(252;0.0458)				GGCACTCAACTACCAGACTGA	0.507			NA											35	129					0	0	0.002852	0	0
ALDH18A1	5832	broad.mit.edu	37	10	97373523	97373523	+	Silent	SNP	G	G	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr10:97373523G>A	uc001kkz.2	-	15	2141	c.1899C>T	c.(1897-1899)ATC>ATT	p.I633I	ALDH18A1_uc001kky.2_Silent_p.I631I|ALDH18A1_uc010qog.1_Silent_p.I522I|ALDH18A1_uc010qoh.1_Silent_p.I421I	NM_002860	NP_002851	P54886	P5CS_HUMAN	pyrroline-5-carboxylate synthetase isoform 1	633	Gamma-glutamyl phosphate reductase.				proline biosynthetic process	mitochondrial inner membrane	ATP binding|glutamate 5-kinase activity|glutamate-5-semialdehyde dehydrogenase activity			pancreas(1)|central_nervous_system(1)|skin(1)	3		Colorectal(252;0.0402)		Epithelial(162;9.1e-07)|all cancers(201;2.55e-05)	L-Glutamic Acid(DB00142)	GCATATCAATGATCTGGTCAA	0.443			NA											24	59					0	0	0.005443	0	0
CNNM1	26507	broad.mit.edu	37	10	101089340	101089340	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr10:101089340G>A	uc001kpp.3	+	1	485	c.196G>A	c.(196-198)GAA>AAA	p.E66K	CNNM1_uc009xwe.2_Missense_Mutation_p.E66K|CNNM1_uc010qpi.1_Missense_Mutation_p.E66K|CNNM1_uc009xwf.2_Missense_Mutation_p.E66K	NM_020348	NP_065081	Q9NRU3	CNNM1_HUMAN	cyclin M1	66					ion transport	integral to membrane|plasma membrane					0		Colorectal(252;0.234)		Epithelial(162;6.82e-10)|all cancers(201;5.62e-08)		GCGCGCCGCCGAAGGCACCAG	0.642			NA											5	18					0	0	0.001984	0	0
ABCC2	1244	broad.mit.edu	37	10	101559009	101559009	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr10:101559009G>C	uc001kqf.2	+	8	1052	c.913G>C	c.(913-915)GTT>CTT	p.V305L		NM_000392	NP_000383	Q92887	MRP2_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP),	305	Cytoplasmic (By similarity).					apical plasma membrane|integral to plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|organic anion transmembrane transporter activity			ovary(1)	1		Colorectal(252;0.234)		Epithelial(162;2.77e-10)|all cancers(201;2.47e-08)	Adenosine triphosphate(DB00171)|Norgestimate(DB00957)|Pravastatin(DB00175)|Saquinavir(DB01232)|Sulfinpyrazone(DB01138)	CAAAAAAGATGTTCCAAAATC	0.393			NA											45	111					0	0	0.002852	0	0
FGF8	2253	broad.mit.edu	37	10	103534631	103534631	+	Silent	SNP	C	C	G			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr10:103534631C>G	uc001ktp.1	-	4	332	c.162G>C	c.(160-162)GTG>GTC	p.V54V	FGF8_uc001ktq.1_Silent_p.V65V|FGF8_uc001ktr.1_Silent_p.V36V|FGF8_uc001kts.1_Silent_p.V25V|FGF8_uc009xwr.1_5'UTR	NM_033164	NP_149354	P55075	FGF8_HUMAN	fibroblast growth factor 8 isoform E precursor	54					bone development|dopaminergic neuron differentiation|fibroblast growth factor receptor signaling pathway|gastrulation|gonad development|insulin receptor signaling pathway|mesonephros development|metanephros development|negative regulation of cardiac muscle tissue development|neuroepithelial cell differentiation|odontogenesis|positive regulation of cell division|positive regulation of cell proliferation	extracellular region|extracellular space	growth factor activity|growth factor activity|type 1 fibroblast growth factor receptor binding|type 2 fibroblast growth factor receptor binding				0		Colorectal(252;0.122)		Epithelial(162;3.94e-09)|all cancers(201;2.13e-07)		TCTGCTCCCTCACATGCTGTG	0.542			NA											16	24					0	0	0.00499	0	0
LDB1	8861	broad.mit.edu	37	10	103869187	103869187	+	Silent	SNP	G	G	C			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr10:103869187G>C	uc009xwz.2	-	9	1153	c.810C>G	c.(808-810)CTC>CTG	p.L270L	LDB1_uc001kuk.3_Silent_p.L234L|LDB1_uc001kul.3_Silent_p.L234L	NM_001113407	NP_001106878	Q86U70	LDB1_HUMAN	LIM domain binding 1 isoform 1	270					histone H3-K4 acetylation|negative regulation of erythrocyte differentiation|negative regulation of transcription, DNA-dependent|positive regulation of hemoglobin biosynthetic process|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription elongation, DNA-dependent|transcription, DNA-dependent|transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery	nuclear chromatin|protein complex	LIM domain binding|protein homodimerization activity|transcription corepressor activity			large_intestine(1)	1		Colorectal(252;0.122)		Epithelial(162;1.11e-07)|all cancers(201;1.82e-06)		GGCAGGTCTTGAGGCAGTCGC	0.592			NA											9	36					0	0	0.008291	0	0
PPRC1	23082	broad.mit.edu	37	10	103901572	103901572	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr10:103901572G>C	uc001kum.2	+	5	3346	c.3307G>C	c.(3307-3309)GAG>CAG	p.E1103Q	PPRC1_uc001kun.2_Missense_Mutation_p.E983Q|PPRC1_uc010qqj.1_Missense_Mutation_p.E1103Q|PPRC1_uc009xxa.2_RNA	NM_015062	NP_055877	Q5VV67	PPRC1_HUMAN	peroxisome proliferator-activated receptor	1103	Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleotide binding|RNA binding			ovary(1)|central_nervous_system(1)|skin(1)	3		Colorectal(252;0.122)		Epithelial(162;4.97e-08)|all cancers(201;8.99e-07)		GCTAAAGCCTGAGACCCAAGA	0.592			NA											3	8					0	0	0.004672	0	0
GBF1	8729	broad.mit.edu	37	10	104019846	104019846	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr10:104019846C>G	uc001kux.1	+	3	376	c.136C>G	c.(136-138)CTA>GTA	p.L46V	GBF1_uc001kuw.2_Missense_Mutation_p.L46V|GBF1_uc001kuy.1_Missense_Mutation_p.L46V|GBF1_uc001kuz.1_Missense_Mutation_p.L46V	NM_004193	NP_004184	Q92538	GBF1_HUMAN	golgi-specific brefeldin A resistant guanine	46					COPI coating of Golgi vesicle|post-Golgi vesicle-mediated transport|regulation of ARF protein signal transduction|retrograde vesicle-mediated transport, Golgi to ER	Golgi membrane	ARF guanyl-nucleotide exchange factor activity|protein binding			ovary(1)|central_nervous_system(1)	2		Colorectal(252;0.0236)		Epithelial(162;5.16e-08)|all cancers(201;1.19e-06)		TTTCGGTCATCTAAAGGAGGT	0.318			NA											30	78					0	0	0.005524	0	0
INA	9118	broad.mit.edu	37	10	105046872	105046872	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr10:105046872G>T	uc001kws.2	+	2	1195	c.1146G>T	c.(1144-1146)TTG>TTT	p.L382F		NM_032727	NP_116116	Q16352	AINX_HUMAN	internexin neuronal intermediate filament	382	Coil 2.|Rod.				cell differentiation|nervous system development	neurofilament	structural constituent of cytoskeleton			ovary(1)|breast(1)	2				Epithelial(162;3.45e-09)|all cancers(201;9.17e-08)|BRCA - Breast invasive adenocarcinoma(275;0.198)		ACCAGGACTTGCTCAATGTCA	0.483			NA											10	32					2.17888e-05	2.52532e-05	0.006214	1	0
C10orf78	119392	broad.mit.edu	37	10	105883606	105883606	+	Silent	SNP	C	C	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr10:105883606C>T	uc001kxu.2	+	3	283	c.270C>T	c.(268-270)TCC>TCT	p.S90S	C10orf78_uc001kxs.2_Silent_p.S77S|C10orf78_uc001kxt.2_Silent_p.S44S|C10orf78_uc001kxv.2_Silent_p.S152S	NM_001002759	NP_001002759	Q86XK3	SFR1_HUMAN	hypothetical protein LOC119392 isoform a	90					double-strand break repair via homologous recombination	Swi5-Sfr1 complex	protein binding				0		Colorectal(252;0.102)|Breast(234;0.122)		Epithelial(162;1.31e-09)|all cancers(201;3.84e-08)|BRCA - Breast invasive adenocarcinoma(275;0.014)		CAGCATCTTCCACAGAGGAAA	0.303			NA											19	38					0	0	0.001882	0	0
SORCS3	22986	broad.mit.edu	37	10	106937921	106937921	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr10:106937921C>A	uc001kyi.1	+	14	2226	c.1999C>A	c.(1999-2001)CAC>AAC	p.H667N	SORCS3_uc010qqz.1_Intron	NM_014978	NP_055793	Q9UPU3	SORC3_HUMAN	VPS10 domain receptor protein SORCS 3 precursor	667	Lumenal (Potential).					integral to membrane	neuropeptide receptor activity			ovary(6)|skin(3)|central_nervous_system(1)	10		Colorectal(252;0.134)|Breast(234;0.142)|Lung NSC(174;0.191)		Epithelial(162;1.58e-07)|all cancers(201;1.02e-05)|BRCA - Breast invasive adenocarcinoma(275;0.0628)		AATGGAGACCCACATCATGAC	0.502	NSCLC(116;1497 1690 7108 13108 14106)		NA											12	26					1.3612e-06	1.67559e-06	0.003163	1	0
SORCS3	22986	broad.mit.edu	37	10	106974319	106974319	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr10:106974319G>T	uc001kyi.1	+	18	2722	c.2495G>T	c.(2494-2496)CGG>CTG	p.R832L	SORCS3_uc010qqz.1_RNA	NM_014978	NP_055793	Q9UPU3	SORC3_HUMAN	VPS10 domain receptor protein SORCS 3 precursor	832	PKD.|Lumenal (Potential).					integral to membrane	neuropeptide receptor activity			ovary(6)|skin(3)|central_nervous_system(1)	10		Colorectal(252;0.134)|Breast(234;0.142)|Lung NSC(174;0.191)		Epithelial(162;1.58e-07)|all cancers(201;1.02e-05)|BRCA - Breast invasive adenocarcinoma(275;0.0628)		ACCGATGGGCGGCTGGTGGCA	0.582	NSCLC(116;1497 1690 7108 13108 14106)		NA											10	29					4.3838e-07	5.45499e-07	0.001855	1	0
DUSP5	1847	broad.mit.edu	37	10	112258062	112258062	+	Silent	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr10:112258062G>T	uc001kzd.2	+	1	438	c.183G>T	c.(181-183)TCG>TCT	p.S61S		NM_004419	NP_004410	Q16690	DUS5_HUMAN	dual specificity phosphatase 5	61	Nuclear localization signal (Potential).|Rhodanese.				endoderm formation|inactivation of MAPK activity	nucleoplasm	MAP kinase tyrosine/serine/threonine phosphatase activity|protein tyrosine phosphatase activity			upper_aerodigestive_tract(1)	1		Breast(234;0.0848)		Epithelial(162;0.000276)|all cancers(201;0.00465)|BRCA - Breast invasive adenocarcinoma(275;0.12)		gcgcggTGTCGGCGCGCTACG	0.662			NA											3	16					0.004672	0.00493414	0.004672	1	0
ATRNL1	26033	broad.mit.edu	37	10	117061393	117061393	+	Silent	SNP	C	C	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr10:117061393C>T	uc001lcg.2	+	17	3044	c.2658C>T	c.(2656-2658)TGC>TGT	p.C886C	ATRNL1_uc010qsm.1_Silent_p.C61C|ATRNL1_uc010qsn.1_RNA	NM_207303	NP_997186	Q5VV63	ATRN1_HUMAN	attractin-like 1 precursor	886	Extracellular (Potential).					integral to membrane	sugar binding			ovary(5)|lung(1)|central_nervous_system(1)	7		all_lung(145;0.0686)|Breast(234;0.0969)|Lung NSC(174;0.17)|Colorectal(252;0.234)		Epithelial(162;0.00031)|all cancers(201;0.000753)|LUSC - Lung squamous cell carcinoma(1;0.0515)|Lung(30;0.0827)		CGAGGCCGTGCAAAAAGCCAT	0.378			NA											15	26					0	0	0.006122	0	0
PNLIPRP2	5408	broad.mit.edu	37	10	118404544	118404544	+	Splice_Site	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr10:118404544G>T	uc001lcq.2	+	16	1373	c.1350_splice	c.e16-1	p.E450_splice		NM_005396	NP_005387	P54317	LIPR2_HUMAN	pancreatic lipase-related protein 2						galactolipid catabolic process|lipid digestion|phospholipid catabolic process|triglyceride metabolic process	extracellular space	acylglycerol lipase activity|calcium ion binding|galactolipase activity|phospholipase activity|triglyceride lipase activity			large_intestine(1)	1				all cancers(201;0.015)		TTCCTCCACAGGTATAATTTT	0.438			NA											5	11					0.000602214	0.00065942	0.000602	1	0
SEC23IP	11196	broad.mit.edu	37	10	121674267	121674267	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr10:121674267G>T	uc001leu.1	+	7	1410	c.1338G>T	c.(1336-1338)TTG>TTT	p.L446F	SEC23IP_uc010qtc.1_Missense_Mutation_p.L235F	NM_007190	NP_009121	Q9Y6Y8	S23IP_HUMAN	Sec23-interacting protein p125	446					Golgi organization|intracellular protein transport	endoplasmic reticulum|ER to Golgi transport vesicle membrane|ER-Golgi intermediate compartment	metal ion binding			ovary(3)	3		Lung NSC(174;0.109)|all_lung(145;0.142)|all_neural(114;0.234)		all cancers(201;0.00515)		TTGACCATTTGGTGTTTGTGG	0.373			NA											71	130					4.45923e-32	7.96979e-32	0.00361	1	0
FGFR2	2263	broad.mit.edu	37	10	123263308	123263308	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr10:123263308C>T	uc010qtk.1	-	11	2082	c.1435G>A	c.(1435-1437)GAT>AAT	p.D479N	FGFR2_uc010qtg.1_Missense_Mutation_p.D367N|FGFR2_uc010qth.1_Missense_Mutation_p.D364N|FGFR2_uc010qti.1_Missense_Mutation_p.D390N|FGFR2_uc010qtj.1_Missense_Mutation_p.D480N|FGFR2_uc010qtl.1_Missense_Mutation_p.D363N|FGFR2_uc010qtm.1_Missense_Mutation_p.D362N|FGFR2_uc001lfl.3_Missense_Mutation_p.D480N|FGFR2_uc001lfm.2_Missense_Mutation_p.D391N|FGFR2_uc001lfg.3_Missense_Mutation_p.D87N	NM_000141	NP_000132	P21802	FGFR2_HUMAN	fibroblast growth factor receptor 2 isoform 1	479	Cytoplasmic (Potential).				angiogenesis|axonogenesis|bone mineralization|bone morphogenesis|branch elongation involved in salivary gland morphogenesis|branching involved in embryonic placenta morphogenesis|branching morphogenesis of a nerve|bud elongation involved in lung branching|cell fate commitment|cell growth|cell-cell signaling|cellular response to protein stimulus|embryonic digestive tract morphogenesis|embryonic pattern specification|epithelial cell proliferation involved in salivary gland morphogenesis|fibroblast growth factor receptor signaling pathway involved in hemopoiesis|fibroblast growth factor receptor signaling pathway involved in mammary gland specification|fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptosis in bone marrow|fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development|fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow|hair follicle morphogenesis|insulin receptor signaling pathway|lacrimal gland development|lateral sprouting from an epithelium|limb bud formation|lung alveolus development|lung lobe morphogenesis|lung-associated mesenchyme development|mammary gland bud formation|membranous septum morphogenesis|mesenchymal cell differentiation involved in lung development|mesenchymal cell proliferation involved in lung development|midbrain development|multicellular organism growth|negative regulation of transcription from RNA polymerase II promoter|odontogenesis|organ growth|otic vesicle formation|outflow tract septum morphogenesis|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cardiac muscle cell proliferation|positive regulation of cell cycle|positive regulation of cell division|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of ERK1 and ERK2 cascade|positive regulation of mesenchymal cell proliferation|positive regulation of transcription from RNA polymerase II promoter|post-embryonic development|prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis|prostate epithelial cord elongation|pyramidal neuron development|regulation of branching involved in prostate gland morphogenesis|regulation of cell fate commitment|regulation of fibroblast growth factor receptor signaling pathway|regulation of multicellular organism growth|regulation of smooth muscle cell differentiation|regulation of smoothened signaling pathway|squamous basal epithelial stem cell differentiation involved in prostate gland acinus development|ureteric bud development|ventricular cardiac muscle tissue morphogenesis|ventricular zone neuroblast division	cell cortex|cell surface|excitatory synapse|extracellular region|integral to membrane|nucleus|plasma membrane	ATP binding|fibroblast growth factor binding|fibroblast growth factor binding|fibroblast growth factor receptor activity|heparin binding|protein binding			endometrium(44)|skin(28)|lung(11)|ovary(4)|cervix(2)|stomach(2)|breast(2)|upper_aerodigestive_tract(1)|soft_tissue(1)|central_nervous_system(1)	96		Lung NSC(174;0.0841)|all_lung(145;0.106)|all_neural(114;0.107)	STAD - Stomach adenocarcinoma(1;7.52e-05)|all cancers(1;0.0722)	all cancers(201;9.73e-05)|GBM - Glioblastoma multiforme(135;0.0845)	Palifermin(DB00039)	ACTCACTTATCTCTTGGAAAC	0.473			5	Mis		gastric. NSCLC|endometrial		Crouzon|Pfeiffer|and Apert syndromes		Apert_syndrome|Saethre-Chotzen_syndrome				10	27					0	0	0.008291	0	0
PTPRE	5791	broad.mit.edu	37	10	129846042	129846042	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr10:129846042G>T	uc001lkb.2	+	5	503	c.224G>T	c.(223-225)AGG>ATG	p.R75M	PTPRE_uc009yat.2_Missense_Mutation_p.R86M|PTPRE_uc010qup.1_RNA|PTPRE_uc009yau.2_Missense_Mutation_p.R75M|PTPRE_uc001lkc.1_RNA|PTPRE_uc001lkd.2_Missense_Mutation_p.R17M|PTPRE_uc010quq.1_5'Flank	NM_006504	NP_006495	P23469	PTPRE_HUMAN	protein tyrosine phosphatase, receptor type, E	75	Cytoplasmic (Potential).				negative regulation of insulin receptor signaling pathway|protein phosphorylation	cytoplasm|integral to membrane|intermediate filament cytoskeleton|nucleus|plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			ovary(1)	1		all_epithelial(44;1.66e-05)|all_lung(145;0.00456)|Lung NSC(174;0.0066)|all_neural(114;0.0936)|Colorectal(57;0.141)|Breast(234;0.166)|Melanoma(40;0.203)				AGGAAGCAGAGGAAAGCTGTG	0.552	Colon(52;977 1184 20575 41685)		NA											13	43					2.32078e-09	3.14299e-09	0.003163	1	0
Unknown	0	broad.mit.edu	37	10	134664626	134664626	+	Missense_Mutation	SNP	C	C	A	rs143825819	byFrequency	TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr10:134664626C>A	uc010qux.1	-	32	4936	c.4936G>T	c.(4936-4938)GGC>TGC	p.G1646C		NM_017609	NP_060079			Homo sapiens cDNA, FLJ17989.												NA						ATTACCAGGCCGACGGAAGTG	0.632			NA											24	58					1.2476e-16	1.99696e-16	0.00632	1	0
FRG2B	441581	broad.mit.edu	37	10	135440114	135440114	+	Nonsense_Mutation	SNP	T	T	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr10:135440114T>A	uc010qvg.1	-	1	186	c.133A>T	c.(133-135)AAG>TAG	p.K45*		NM_001080998	NP_001074467	Q96QU4	FRG2B_HUMAN	FSHD region gene 2 family, member B	45						nucleus					0		all_cancers(35;7.01e-07)|all_epithelial(44;1.45e-05)|Lung NSC(174;0.027)|all_lung(145;0.0384)|all_neural(114;0.0726)|Glioma(114;0.172)|Melanoma(40;0.175)		OV - Ovarian serous cystadenocarcinoma(35;1.12e-06)|all cancers(32;1.43e-06)|Epithelial(32;1.71e-06)		AAGGCGGTCTTGCCTTTTTCT	0.507			NA											12	33					0	0	0.004007	0	0
NLRP6	171389	broad.mit.edu	37	11	281085	281085	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr11:281085G>C	uc010qvs.1	+	4	1351	c.1351G>C	c.(1351-1353)GAG>CAG	p.E451Q	NLRP6_uc010qvt.1_Missense_Mutation_p.E451Q	NM_138329	NP_612202	P59044	NALP6_HUMAN	NLR family, pyrin domain containing 6	451	NACHT.					cytoplasm	ATP binding			upper_aerodigestive_tract(1)|skin(1)	2		all_cancers(49;1.12e-06)|all_epithelial(84;0.000375)|Breast(177;0.00122)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;4.28e-28)|Epithelial(43;2.47e-27)|OV - Ovarian serous cystadenocarcinoma(40;4.66e-21)|BRCA - Breast invasive adenocarcinoma(625;3.57e-05)|Lung(200;0.0485)|LUSC - Lung squamous cell carcinoma(625;0.122)		CCTGGCCCGCGAGGGCGTCCT	0.627			NA											14	28					0	0	0.00245	0	0
IFITM2	10581	broad.mit.edu	37	11	309045	309045	+	Silent	SNP	C	C	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr11:309045C>T	uc001lox.3	+	2	365	c.279C>T	c.(277-279)ACC>ACT	p.T93T		NM_006435	NP_006426	Q01629	IFM2_HUMAN	interferon induced transmembrane protein 2	93	Cytoplasmic (Potential).				response to virus|type I interferon-mediated signaling pathway	integral to membrane|plasma membrane	protein binding				0		all_cancers(49;2e-09)|all_epithelial(84;3.36e-06)|Breast(177;0.000162)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.0538)|all_lung(207;0.0713)		all cancers(45;5.73e-28)|Epithelial(43;3.42e-27)|OV - Ovarian serous cystadenocarcinoma(40;1.14e-20)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0328)|LUSC - Lung squamous cell carcinoma(625;0.122)		GCGACGTGACCGGGGCCCAGG	0.602			NA											4	33					0	0	0.008291	0	0
TRPM5	29850	broad.mit.edu	37	11	2441587	2441587	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr11:2441587G>T	uc001lwm.3	-	4	523	c.514C>A	c.(514-516)CCC>ACC	p.P172T	TRPM5_uc010qxl.1_Missense_Mutation_p.P172T|TRPM5_uc009ydn.2_Missense_Mutation_p.P174T	NM_014555	NP_055370	Q9NZQ8	TRPM5_HUMAN	transient receptor potential cation channel,	172	Cytoplasmic (Potential).					integral to membrane|plasma membrane	receptor activity|voltage-gated ion channel activity			ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	4		Medulloblastoma(188;0.0049)|Breast(177;0.00586)|all_epithelial(84;0.0075)|Ovarian(85;0.0256)|all_neural(188;0.0311)		BRCA - Breast invasive adenocarcinoma(625;0.00147)|LUSC - Lung squamous cell carcinoma(625;0.191)		GAACAGAGGGGGCCCTGGCTG	0.667	NSCLC(1;49 61 17205 18850 43201)		NA											17	30					1.33834e-09	1.82244e-09	0.007413	1	0
OR52K2	119774	broad.mit.edu	37	11	4470617	4470617	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr11:4470617G>T	uc001lyz.1	+	1	48	c.48G>T	c.(46-48)TTG>TTT	p.L16F		NM_001005172	NP_001005172	Q8NGK3	O52K2_HUMAN	olfactory receptor, family 52, subfamily K,	16	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;1.48e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0821)|LUSC - Lung squamous cell carcinoma(625;0.19)		CCTTCTTGTTGGTGGGGATTC	0.517			NA											16	36					4.96729e-08	6.42292e-08	0.008871	1	0
OR52R1	119695	broad.mit.edu	37	11	4825366	4825366	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr11:4825366G>T	uc010qym.1	-	1	482	c.482C>A	c.(481-483)CCT>CAT	p.P161H		NM_001005177	NP_001005177	Q8NGF1	O52R1_HUMAN	olfactory receptor, family 52, subfamily R,	82	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1		Medulloblastoma(188;0.0025)|Breast(177;0.0184)|all_neural(188;0.0227)		Epithelial(150;4.77e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00435)|LUSC - Lung squamous cell carcinoma(625;0.19)		CAACATCTTAGGTTGAGTGGA	0.498			NA											17	43					3.41278e-10	4.72955e-10	0.00499	1	0
OR51G1	79324	broad.mit.edu	37	11	4944844	4944844	+	Silent	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr11:4944844G>T	uc010qyr.1	-	1	726	c.726C>A	c.(724-726)ACC>ACA	p.T242T		NM_001005237	NP_001005237	Q8NGK1	O51G1_HUMAN	olfactory receptor, family 51, subfamily G,	242	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;2.58e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0284)|LUSC - Lung squamous cell carcinoma(625;0.19)		GAGAGACACAGGTGTTGAGGG	0.552			NA											15	76					8.28177e-16	1.30317e-15	0.007413	1	0
MMP26	56547	broad.mit.edu	37	11	5012612	5012612	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr11:5012612G>T	uc001lzv.2	+	4	499	c.481G>T	c.(481-483)GGT>TGT	p.G161C		NM_021801	NP_068573	Q9NRE1	MMP26_HUMAN	matrix metalloproteinase 26 preproprotein	161					collagen catabolic process|proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding				0		Medulloblastoma(188;0.0025)|Breast(177;0.0204)|all_neural(188;0.0227)		Epithelial(150;1.33e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0287)|LUSC - Lung squamous cell carcinoma(625;0.191)		CCATGAAGATGGTTGGCCCTT	0.458			NA											86	162					7.62712e-44	1.40365e-43	0.00361	1	0
OR51B5	282763	broad.mit.edu	37	11	5364143	5364143	+	Missense_Mutation	SNP	T	T	C			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr11:5364143T>C	uc001map.1	-	1	612	c.612A>G	c.(610-612)ATA>ATG	p.I204M	HBG2_uc001mak.1_Intron|HBE1_uc001mam.1_Intron	NM_001005567	NP_001005567	Q9H339	O51B5_HUMAN	olfactory receptor, family 51, subfamily B,	204	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;3.05e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CCAGCACAAATATAAAGACTA	0.453			NA											35	52					0	0	0.003755	0	0
OR51Q1	390061	broad.mit.edu	37	11	5443647	5443647	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr11:5443647C>A	uc010qzd.1	+	1	217	c.217C>A	c.(217-219)CTG>ATG	p.L73M	HBG2_uc001mak.1_Intron|HBE1_uc001mam.1_Intron|OR51B5_uc001maq.1_Intron	NM_001004757	NP_001004757	Q8NH59	O51Q1_HUMAN	olfactory receptor, family 51, subfamily Q,	73	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;2.18e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CCTGACGGACCTGGGTCTCAC	0.532			NA											16	80					3.51602e-12	5.14092e-12	0.008871	1	0
OR51I2	390064	broad.mit.edu	37	11	5474794	5474794	+	Missense_Mutation	SNP	T	T	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr11:5474794T>A	uc010qzf.1	+	1	76	c.76T>A	c.(76-78)TGG>AGG	p.W26R	HBG2_uc001mak.1_Intron|HBE1_uc001mam.1_Intron|OR51B5_uc001maq.1_Intron	NM_001004754	NP_001004754	Q9H344	O51I2_HUMAN	olfactory receptor, family 51, subfamily I,	26	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(2)	4		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;1.09e-10)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CTCTCACTCCTGGCTGTCAGG	0.547			NA											10	40					0	0	0.003163	0	0
OR51I2	390064	broad.mit.edu	37	11	5474804	5474804	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr11:5474804G>A	uc010qzf.1	+	1	86	c.86G>A	c.(85-87)GGG>GAG	p.G29E	HBG2_uc001mak.1_Intron|HBE1_uc001mam.1_Intron|OR51B5_uc001maq.1_Intron	NM_001004754	NP_001004754	Q9H344	O51I2_HUMAN	olfactory receptor, family 51, subfamily I,	29	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(2)	4		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;1.09e-10)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TGGCTGTCAGGGCCCCTCTGC	0.547			NA											9	39					0	0	0.003163	0	0
OR52N4	390072	broad.mit.edu	37	11	5776462	5776462	+	Silent	SNP	C	C	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr11:5776462C>T	uc001mbu.2	+	1	540	c.492C>T	c.(490-492)CTC>CTT	p.L164L	TRIM5_uc001mbq.1_Intron|TRIM22_uc009yet.1_Intron	NM_001005175	NP_001005175	Q8NGI2	O52N4_HUMAN	olfactory receptor, family 52, subfamily N,	164	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;1.87e-10)|LUSC - Lung squamous cell carcinoma(625;0.114)|BRCA - Breast invasive adenocarcinoma(625;0.135)|Lung(200;0.197)		TTACTTTCCTCACCAAGCTCC	0.463			NA											27	50					0	0	0.002836	0	0
OR56A1	120796	broad.mit.edu	37	11	6048549	6048549	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr11:6048549C>A	uc010qzw.1	-	1	386	c.386G>T	c.(385-387)CGT>CTT	p.R129L		NM_001001917	NP_001001917	Q8NGH5	O56A1_HUMAN	olfactory receptor, family 56, subfamily A,	129	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|breast(1)	3		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;7.01e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GGCCACATAACGGTCATAGGC	0.507			NA											9	37					5.4927e-09	7.31868e-09	0.004482	1	0
CNGA4	1262	broad.mit.edu	37	11	6261363	6261363	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr11:6261363G>T	uc001mco.2	+	4	446	c.339G>T	c.(337-339)TGG>TGT	p.W113C	CNGA4_uc010raa.1_Intron|CNGA4_uc001mcn.2_Missense_Mutation_p.W73C	NM_001037329	NP_001032406	Q8IV77	CNGA4_HUMAN	cyclic nucleotide gated channel alpha 4	113	Helical; Name=H3; (Potential).				response to stimulus|sensory perception of smell		cAMP binding			skin(1)	1		Medulloblastoma(188;0.00263)|all_neural(188;0.026)|Breast(177;0.029)		Epithelial(150;2.04e-08)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TTCGCACCTGGAGTTTCTTCT	0.617			NA											17	100					2.94398e-08	3.84684e-08	0.007413	1	0
CNGA4	1262	broad.mit.edu	37	11	6262679	6262679	+	Silent	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr11:6262679C>A	uc001mco.2	+	5	1043	c.936C>A	c.(934-936)ATC>ATA	p.I312I	CNGA4_uc010raa.1_Silent_p.I81I|CNGA4_uc001mcn.2_Silent_p.I272I	NM_001037329	NP_001032406	Q8IV77	CNGA4_HUMAN	cyclic nucleotide gated channel alpha 4	312	Cytoplasmic (Potential).				response to stimulus|sensory perception of smell		cAMP binding			skin(1)	1		Medulloblastoma(188;0.00263)|all_neural(188;0.026)|Breast(177;0.029)		Epithelial(150;2.04e-08)|BRCA - Breast invasive adenocarcinoma(625;0.135)		ACCTGCAGATCAACAAGAAGA	0.562			NA											11	57					3.86212e-05	4.42789e-05	0.008291	1	0
OR10A2	341276	broad.mit.edu	37	11	6891001	6891001	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr11:6891001C>A	uc001meu.1	+	1	16	c.16C>A	c.(16-18)CTG>ATG	p.L6M		NM_001004460	NP_001004460	Q9H208	O10A2_HUMAN	olfactory receptor, family 10, subfamily A,	6	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)	1		Medulloblastoma(188;0.0523)|all_neural(188;0.236)		Epithelial(150;4.89e-08)|BRCA - Breast invasive adenocarcinoma(625;0.13)		CTTCTCTTCCCTGCCTACTGA	0.443			NA											27	149					7.11191e-15	1.0925e-14	0.002836	1	0
OR10A2	341276	broad.mit.edu	37	11	6891503	6891503	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr11:6891503G>A	uc001meu.1	+	1	518	c.518G>A	c.(517-519)AGG>AAG	p.R173K		NM_001004460	NP_001004460	Q9H208	O10A2_HUMAN	olfactory receptor, family 10, subfamily A,	173	Extracellular (Potential).			R -> K (in Ref. 4; AAK95109).	sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)	1		Medulloblastoma(188;0.0523)|all_neural(188;0.236)		Epithelial(150;4.89e-08)|BRCA - Breast invasive adenocarcinoma(625;0.13)		CCTGTGCTGAGGCTGGTCTGT	0.507			NA											5	94					0	0	0.000602	0	0
OR10A4	283297	broad.mit.edu	37	11	6898039	6898039	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr11:6898039C>A	uc010rat.1	+	1	161	c.161C>A	c.(160-162)TCT>TAT	p.S54Y		NM_207186	NP_997069	Q9H209	O10A4_HUMAN	olfactory receptor, family 10, subfamily A,	54	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		Medulloblastoma(188;0.0523)|all_neural(188;0.236)		Epithelial(150;4.78e-08)|BRCA - Breast invasive adenocarcinoma(625;0.129)		ATAGCTGACTCTGCACTACAA	0.453			NA											26	103					8.4185e-14	1.26448e-13	0.002445	1	0
ZNF214	7761	broad.mit.edu	37	11	7021487	7021487	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr11:7021487C>A	uc001mfa.2	-	3	1730	c.1427G>T	c.(1426-1428)GGG>GTG	p.G476V	ZNF214_uc010ray.1_Missense_Mutation_p.G476V|ZNF214_uc009yfh.1_Missense_Mutation_p.G476V	NM_013249	NP_037381	Q9UL59	ZN214_HUMAN	zinc finger protein 214	476	C2H2-type 8.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1				Epithelial(150;3.87e-08)|BRCA - Breast invasive adenocarcinoma(625;0.081)		GAAGCCCTTCCCACATTCAGG	0.443	Ovarian(22;251 657 736 21522 46864)		NA											10	50					1.61879e-10	2.25599e-10	0.001368	1	0
EIF4G2	1982	broad.mit.edu	37	11	10827457	10827457	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr11:10827457C>G	uc001mjc.2	-	4	662	c.245G>C	c.(244-246)AGA>ACA	p.R82T	EIF4G2_uc001mjb.2_5'UTR|EIF4G2_uc009ygf.2_5'UTR|EIF4G2_uc001mjd.2_Missense_Mutation_p.R82T|EIF4G2_uc001mjf.1_5'UTR	NM_001418	NP_001409	P78344	IF4G2_HUMAN	eukaryotic translation initiation factor 4	82	MIF4G.				cell cycle arrest|cell death|regulation of translational initiation|RNA metabolic process	eukaryotic translation initiation factor 4F complex	protein binding|translation initiation factor activity			ovary(1)|central_nervous_system(1)	2				all cancers(16;2.8e-07)|Epithelial(150;4.18e-07)|BRCA - Breast invasive adenocarcinoma(625;0.111)		AACTTACCCTCTTACTTTCCT	0.433			NA											51	124					0	0	0.00361	0	0
USH1C	10083	broad.mit.edu	37	11	17553016	17553016	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr11:17553016C>G	uc001mnf.2	-	3	287	c.178G>C	c.(178-180)GAT>CAT	p.D60H	USH1C_uc001mne.2_Missense_Mutation_p.D60H|USH1C_uc009yhb.2_Missense_Mutation_p.D60H|USH1C_uc001mng.2_RNA|USH1C_uc001mnd.2_Missense_Mutation_p.D24H	NM_005709	NP_005700	Q9Y6N9	USH1C_HUMAN	harmonin isoform a	60					equilibrioception|G2/M transition of mitotic cell cycle|photoreceptor cell maintenance|sensory perception of sound	apical part of cell|cytoplasm|stereocilium	protein binding			ovary(1)	1						CGAATGGCATCAAACAGAGGC	0.617			NA											14	17					0	0	0.004007	0	0
MRGPRX4	117196	broad.mit.edu	37	11	18194994	18194994	+	Missense_Mutation	SNP	A	A	G			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr11:18194994A>G	uc001mnv.1	+	1	611	c.191A>G	c.(190-192)TAC>TGC	p.Y64C		NM_054032	NP_473373	Q96LA9	MRGX4_HUMAN	MAS-related GPR, member X4	64	Helical; Name=2; (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			skin(1)	1						GTCTCCATCTACATCCTCAAC	0.537			NA											8	44					0	0	0.004482	0	0
IGSF22	283284	broad.mit.edu	37	11	18739579	18739579	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr11:18739579G>T	uc009yht.2	-	9	1062	c.872C>A	c.(871-873)ACC>AAC	p.T291N	IGSF22_uc001mpa.2_RNA	NM_173588	NP_775859	Q8N9C0	IGS22_HUMAN	immunoglobulin superfamily, member 22	291	Ig-like 2.									ovary(4)|large_intestine(2)|kidney(1)	7						CATGTACTTGGTGCCCATCTG	0.532			NA											17	65					2.35188e-11	3.34985e-11	0.006122	1	0
PTPN5	84867	broad.mit.edu	37	11	18754793	18754793	+	Nonsense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr11:18754793C>A	uc001mpd.2	-	11	1638	c.1207G>T	c.(1207-1209)GAG>TAG	p.E403*	PTPN5_uc001mpb.2_Nonsense_Mutation_p.E371*|PTPN5_uc001mpc.2_Nonsense_Mutation_p.E403*|PTPN5_uc001mpe.2_Nonsense_Mutation_p.E371*|PTPN5_uc010rdj.1_Nonsense_Mutation_p.E347*|PTPN5_uc001mpf.2_Nonsense_Mutation_p.E379*|PTPN5_uc010rdk.1_Nonsense_Mutation_p.E348*	NM_006906	NP_008837	P54829	PTN5_HUMAN	protein-tyrosine-phosphatase non-receptor 5	403	Tyrosine-protein phosphatase.					integral to membrane	phosphotyrosine binding|protein tyrosine phosphatase activity			ovary(2)	2						TCGTTCATCTCCTCGATGTTG	0.433			NA											32	69					1.90571e-15	2.9798e-15	0.004289	1	0
NAV2	89797	broad.mit.edu	37	11	20113751	20113751	+	Splice_Site	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr11:20113751G>T	uc001mpr.3	+	28	6023	c.5662_splice	c.e28-1	p.S1888_splice	NAV2_uc001mpp.2_Splice_Site_p.S1821_splice|NAV2_uc009yhx.2_Splice_Site_p.S949_splice|NAV2_uc009yhz.2_Splice_Site_p.S530_splice|NAV2_uc001mpu.2_Splice_Site_p.S323_splice	NM_182964	NP_892009	Q8IVL1	NAV2_HUMAN	neuron navigator 2 isoform 1							nucleus	ATP binding|helicase activity			skin(4)|ovary(1)|pancreas(1)	6						ACTCTTTGCAGAGTGAAATAG	0.488			NA											18	43					4.96729e-08	6.42292e-08	0.008871	1	0
MUC15	143662	broad.mit.edu	37	11	26582746	26582746	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr11:26582746G>A	uc001mqx.2	-	4	1137	c.871C>T	c.(871-873)CCT>TCT	p.P291S	ANO3_uc010rdr.1_Intron|ANO3_uc001mqt.3_Intron|ANO3_uc010rds.1_Intron|ANO3_uc010rdt.1_Intron|MUC15_uc001mqw.2_Missense_Mutation_p.P318S|MUC15_uc001mqy.2_Missense_Mutation_p.P268S	NM_145650	NP_663625	Q8N387	MUC15_HUMAN	mucin 15 isoform b	291	Cytoplasmic (Potential).					extracellular region|integral to membrane|plasma membrane				ovary(1)|central_nervous_system(1)|pancreas(1)	3						ACATCATAAGGTTCCGGTGCA	0.378			NA											3	28					0	0	0.009096	0	0
KCNA4	3739	broad.mit.edu	37	11	30033752	30033752	+	Silent	SNP	A	A	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr11:30033752A>T	uc001msk.2	-	2	1626	c.474T>A	c.(472-474)CCT>CCA	p.P158P		NM_002233	NP_002224	P22459	KCNA4_HUMAN	potassium voltage-gated channel, shaker-related	158						voltage-gated potassium channel complex	potassium ion binding|protein binding|voltage-gated potassium channel activity			ovary(2)|central_nervous_system(1)|pancreas(1)	4						CCTCATCCTGAGGCAGCAGAT	0.403			NA											7	54					0	0	0.00308	0	0
Unknown	0	broad.mit.edu	37	11	31086068	31086068	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr11:31086068C>T	uc009yjk.1	-	8	952	c.883G>A	c.(883-885)GTA>ATA	p.V295I	uc009yjl.1_Missense_Mutation_p.V223I|DCDC1_uc001msu.1_Missense_Mutation_p.V466I					RecName: Full=Doublecortin domain-containing protein 5;												NA						ACCAGTGCTACTGTCAGCTCC	0.488			NA											36	69					0	0	0.00874	0	0
ELP4	26610	broad.mit.edu	37	11	31671690	31671690	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr11:31671690G>T	uc001mtb.2	+	9	1099	c.1064G>T	c.(1063-1065)CGG>CTG	p.R355L	ELP4_uc001mta.1_RNA|ELP4_uc001mtc.2_Missense_Mutation_p.R355L|ELP4_uc010rdz.1_Missense_Mutation_p.R356L	NM_019040	NP_061913	Q96EB1	ELP4_HUMAN	elongation protein 4 homolog	355					histone acetylation|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|DNA-directed RNA polymerase II, holoenzyme|Elongator holoenzyme complex|transcription elongation factor complex	phosphorylase kinase regulator activity|protein binding			upper_aerodigestive_tract(1)|ovary(1)|prostate(1)	3	Lung SC(675;0.225)					CAGATTCCTCGGCTTAATAAC	0.284			NA											4	33					4.096e-09	5.49211e-09	0.001168	1	0
C11orf41	25758	broad.mit.edu	37	11	33667548	33667548	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr11:33667548G>T	uc001mup.3	+	16	4977	c.4853G>T	c.(4852-4854)CGC>CTC	p.R1618L		NM_012194	NP_036326	Q6ZVL6	CK041_HUMAN	hypothetical protein LOC25758	1612						integral to membrane				ovary(2)	2						CCGACCTACCGCCCAGAAATG	0.627			NA											3	10					2.56e-06	3.10246e-06	0.009096	1	0
FBXO3	26273	broad.mit.edu	37	11	33777464	33777464	+	Silent	SNP	G	G	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr11:33777464G>A	uc001muz.2	-	5	559	c.531C>T	c.(529-531)GTC>GTT	p.V177V	FBXO3_uc010rej.1_5'Flank|FBXO3_uc001muy.2_Silent_p.V64V|FBXO3_uc009ykb.2_RNA|FBXO3_uc001mva.1_Silent_p.V177V|FBXO3_uc001mvb.1_Silent_p.V172V|FBXO3_uc010rek.1_Intron	NM_012175	NP_036307	Q9UK99	FBX3_HUMAN	F-box only protein 3 isoform 1	177					proteolysis	nucleus	ubiquitin-protein ligase activity	p.V177I(1)		pancreas(1)	1		Lung NSC(402;0.0804)		BRCA - Breast invasive adenocarcinoma(625;0.00315)|Lung(977;0.00488)|LUSC - Lung squamous cell carcinoma(625;0.008)		CAGCTGTATCGACGTCTAACA	0.453			NA											3	47					0	0	0.000602	0	0
NAT10	55226	broad.mit.edu	37	11	34129826	34129826	+	Silent	SNP	A	A	G			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr11:34129826A>G	uc001mvk.2	+	2	298	c.54A>G	c.(52-54)GTA>GTG	p.V18V	NAT10_uc010ren.1_Intron	NM_024662	NP_078938	Q9H0A0	NAT10_HUMAN	N-acetyltransferase 10 isoform a	18						nucleolus	ATP binding|N-acetyltransferase activity|protein binding			ovary(1)|skin(1)	2		Acute lymphoblastic leukemia(5;0.0119)|all_hematologic(20;0.0231)				AGAATGGAGTAGCTGAGCGGC	0.408			NA											35	87					0	0	0.004878	0	0
PAMR1	25891	broad.mit.edu	37	11	35496271	35496271	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr11:35496271G>T	uc001mwg.2	-	4	444	c.401C>A	c.(400-402)GCC>GAC	p.A134D	PAMR1_uc001mwf.2_Missense_Mutation_p.A134D|PAMR1_uc010rew.1_Intron|PAMR1_uc010rex.1_Missense_Mutation_p.A94D	NM_001001991	NP_001001991	Q6UXH9	PAMR1_HUMAN	regeneration associated muscle protease isoform	134	CUB.				proteolysis	extracellular region	serine-type endopeptidase activity			ovary(2)	2						ACCCTTTGGGGCTCGCAGAAC	0.433			NA											13	39					1.99824e-07	2.51812e-07	0.00499	1	0
RAG1	5896	broad.mit.edu	37	11	36594961	36594961	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr11:36594961G>T	uc001mwu.3	+	2	231	c.107G>T	c.(106-108)AGA>ATA	p.R36I	RAG1_uc001mwt.2_RNA	NM_000448	NP_000439	P15918	RAG1_HUMAN	recombination activating gene 1	36	Interaction with importin alpha-1.				histone monoubiquitination|immune response|pre-B cell allelic exclusion|protein autoubiquitination|T cell differentiation in thymus|V(D)J recombination	nucleus	endonuclease activity|histone binding|protein homodimerization activity|sequence-specific DNA binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|pancreas(1)|lung(1)|kidney(1)|skin(1)	5	all_lung(20;0.226)	all_hematologic(20;0.107)				TTCCGGGTGAGATCCTTTGAA	0.468	Pancreas(43;321 1249 3212 48200)|Esophageal Squamous(38;49 1003 17530 24363)		NA							Familial_Hemophagocytic_Lymphohistiocytosis				11	33					1.58986e-06	1.94739e-06	0.008291	1	0
TTC17	55761	broad.mit.edu	37	11	43423014	43423014	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr11:43423014G>T	uc001mxi.2	+	10	1252	c.1238G>T	c.(1237-1239)CGA>CTA	p.R413L	TTC17_uc001mxh.2_Missense_Mutation_p.R413L|TTC17_uc010rfj.1_Missense_Mutation_p.R356L|TTC17_uc001mxj.2_Missense_Mutation_p.R183L	NM_018259	NP_060729	Q96AE7	TTC17_HUMAN	tetratricopeptide repeat domain 17	413							binding			ovary(5)	5						CAGATATGCCGACTGGTCAAC	0.398			NA											5	22					6.5536e-12	9.53542e-12	0.00308	1	0
NR1H3	10062	broad.mit.edu	37	11	47282960	47282960	+	Missense_Mutation	SNP	A	A	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr11:47282960A>T	uc009ylm.2	+	5	889	c.668A>T	c.(667-669)CAG>CTG	p.Q223L	NR1H3_uc009yll.1_Missense_Mutation_p.Q229L|NR1H3_uc010rhk.1_Missense_Mutation_p.Q229L|NR1H3_uc001nek.2_Missense_Mutation_p.Q178L|NR1H3_uc001nej.2_Missense_Mutation_p.Q223L|NR1H3_uc001nel.2_Missense_Mutation_p.Q178L|NR1H3_uc001nen.3_Missense_Mutation_p.Q223L|NR1H3_uc001nem.2_Missense_Mutation_p.Q223L|NR1H3_uc001nep.2_Missense_Mutation_p.Q132L	NM_005693	NP_005684	Q13133	NR1H3_HUMAN	nuclear receptor subfamily 1, group H, member 3	223	Ligand-binding (Potential).				apoptotic cell clearance|cellular response to lipopolysaccharide|cholesterol homeostasis|negative regulation of cholesterol storage|negative regulation of inflammatory response|negative regulation of interferon-gamma-mediated signaling pathway|negative regulation of lipid transport|negative regulation of macrophage activation|negative regulation of pancreatic juice secretion|negative regulation of pinocytosis|negative regulation of secretion of lysosomal enzymes|negative regulation of transcription from RNA polymerase II promoter|positive regulation of cellular protein metabolic process|positive regulation of cholesterol efflux|positive regulation of cholesterol homeostasis|positive regulation of fatty acid biosynthetic process|positive regulation of lipoprotein lipase activity|positive regulation of receptor biosynthetic process|positive regulation of toll-like receptor 4 signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of triglyceride biosynthetic process|regulation of circadian rhythm|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to progesterone stimulus|triglyceride homeostasis	nuclear chromatin|nucleoplasm	cholesterol binding|steroid hormone receptor activity|sterol response element binding|transcription coactivator activity|zinc ion binding			ovary(2)|lung(1)	3						GCCCAGCAACAGTGTAACCGG	0.617			NA											12	42					0	0	0.003163	0	0
MADD	8567	broad.mit.edu	37	11	47312232	47312232	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr11:47312232G>T	uc001ner.1	+	20	3417	c.3226G>T	c.(3226-3228)GGG>TGG	p.G1076W	MADD_uc001neq.2_Missense_Mutation_p.G1056W|MADD_uc001nev.1_Missense_Mutation_p.G1013W|MADD_uc001nes.1_Missense_Mutation_p.G1033W|MADD_uc001net.1_Missense_Mutation_p.G1076W|MADD_uc009yln.1_Missense_Mutation_p.G1013W|MADD_uc001neu.1_Missense_Mutation_p.G1013W|MADD_uc001nex.2_Missense_Mutation_p.G1076W|MADD_uc001nez.2_Missense_Mutation_p.G1013W|MADD_uc001new.2_Missense_Mutation_p.G1056W|MADD_uc009ylo.2_5'UTR	NM_003682	NP_003673	Q8WXG6	MADD_HUMAN	MAP-kinase activating death domain-containing	1076					activation of MAPK activity|apoptosis|cell surface receptor linked signaling pathway|regulation of apoptosis|regulation of cell cycle	cytoplasm|integral to membrane|plasma membrane	death receptor binding|protein kinase activator activity|Rab guanyl-nucleotide exchange factor activity			ovary(5)|skin(4)|central_nervous_system(2)	11				Lung(87;0.182)		TGGCCTAGCTGGGCGGGGGGA	0.537			NA											7	35					0.00307968	0.00328514	0.00308	1	0
OR4A15	81328	broad.mit.edu	37	11	55135425	55135425	+	Silent	SNP	G	G	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr11:55135425G>A	uc010rif.1	+	1	66	c.66G>A	c.(64-66)CTG>CTA	p.L22L		NM_001005275	NP_001005275	Q8NGL6	O4A15_HUMAN	olfactory receptor, family 4, subfamily A,	22	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						TCCGACACCTGAGTCCAACAC	0.408			NA											6	32					0	0	0.001984	0	0
OR4A15	81328	broad.mit.edu	37	11	55136164	55136164	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr11:55136164G>T	uc010rif.1	+	1	805	c.805G>T	c.(805-807)GCA>TCA	p.A269S		NM_001005275	NP_001005275	Q8NGL6	O4A15_HUMAN	olfactory receptor, family 4, subfamily A,	269	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						CTACACCTGTGCATCCCACGT	0.423			NA											29	61					2.12542e-12	3.1323e-12	0.00632	1	0
OR4C15	81309	broad.mit.edu	37	11	55321886	55321886	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr11:55321886G>T	uc010rig.1	+	1	104	c.104G>T	c.(103-105)TGT>TTT	p.C35F		NM_001001920	NP_001001920	Q8NGM1	OR4CF_HUMAN	olfactory receptor, family 4, subfamily C,	Error:Variant_position_missing_in_Q8NGM1_after_alignment					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						ATTTTCCTTTGTCCTAATTGC	0.378			NA								HNSCC(20;0.049)			8	69					5.4927e-09	7.31868e-09	0.004482	1	0
OR4C11	219429	broad.mit.edu	37	11	55371142	55371142	+	Silent	SNP	G	G	A	rs146621611	byFrequency	TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr11:55371142G>A	uc010rii.1	-	1	708	c.708C>T	c.(706-708)TCC>TCT	p.S236S		NM_001004700	NP_001004700	Q6IEV9	OR4CB_HUMAN	olfactory receptor, family 4, subfamily C,	236	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						ACGTGCAAGCGGAGAGAGCCT	0.413			NA											5	25					0	0	0.001168	0	0
OR4C6	219432	broad.mit.edu	37	11	55433503	55433503	+	Silent	SNP	G	G	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr11:55433503G>A	uc001nht.3	+	3	1126	c.861G>A	c.(859-861)CTG>CTA	p.L287L	OR4C6_uc010rik.1_Silent_p.L287L	NM_001004704	NP_001004704	Q8NH72	OR4C6_HUMAN	olfactory receptor, family 4, subfamily C,	287	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2						TCTATACACTGAGGAATGCAG	0.453			NA											14	31					0	0	0.007413	0	0
OR5D13	390142	broad.mit.edu	37	11	55540930	55540930	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr11:55540930G>C	uc010ril.1	+	1	17	c.17G>C	c.(16-18)AGA>ACA	p.R6T		NM_001001967	NP_001001967	Q8NGL4	OR5DD_HUMAN	olfactory receptor, family 5, subfamily D,	6	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.R6I(1)		ovary(1)|pancreas(1)|skin(1)	3		all_epithelial(135;0.196)				GCATCTGAAAGAAATCAAAGC	0.378			NA											10	73					0	0	0.003163	0	0
SPRYD5	84767	broad.mit.edu	37	11	55653632	55653632	+	Nonsense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr11:55653632G>T	uc010rip.1	+	3	537	c.445G>T	c.(445-447)GAA>TAA	p.E149*	SPRYD5_uc010riq.1_Nonsense_Mutation_p.E6*	NM_032681	NP_116070	Q9BSJ1	SPRY5_HUMAN	SPRY domain containing 5	149						intracellular	zinc ion binding				0		all_epithelial(135;0.226)				GTCTTTATGGGAAAAAGCTTG	0.408			NA											3	28					0.00024832	0.000277424	0.009096	1	0
OR5AS1	219447	broad.mit.edu	37	11	55798346	55798346	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr11:55798346G>T	uc010riw.1	+	1	452	c.452G>T	c.(451-453)AGT>ATT	p.S151I		NM_001001921	NP_001001921	Q8N127	O5AS1_HUMAN	olfactory receptor, family 5, subfamily AS,	151	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(3)|liver(1)|skin(1)	5	Esophageal squamous(21;0.00693)					GCATATTTCAGTGGAAGTACA	0.448			NA											9	111					0.00829132	0.00871937	0.008291	1	0
OR5AS1	219447	broad.mit.edu	37	11	55798392	55798392	+	Silent	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr11:55798392G>T	uc010riw.1	+	1	498	c.498G>T	c.(496-498)CTG>CTT	p.L166L		NM_001001921	NP_001001921	Q8N127	O5AS1_HUMAN	olfactory receptor, family 5, subfamily AS,	166	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(3)|liver(1)|skin(1)	5	Esophageal squamous(21;0.00693)					CATTCAGGCTGTCATTTTGTG	0.438			NA											15	162					2.35188e-11	3.34985e-11	0.006122	1	0
OR5AS1	219447	broad.mit.edu	37	11	55798567	55798567	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr11:55798567G>T	uc010riw.1	+	1	673	c.673G>T	c.(673-675)GTG>TTG	p.V225L		NM_001001921	NP_001001921	Q8N127	O5AS1_HUMAN	olfactory receptor, family 5, subfamily AS,	225	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(3)|liver(1)|skin(1)	5	Esophageal squamous(21;0.00693)					CCTCATCACTGTGTTGAGCAT	0.448			NA											39	74					4.42602e-33	7.94867e-33	0.00874	1	0
OR5T3	390154	broad.mit.edu	37	11	56020058	56020058	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr11:56020058C>G	uc010rjd.1	+	1	383	c.383C>G	c.(382-384)GCA>GGA	p.A128G		NM_001004747	NP_001004747	Q8NGG3	OR5T3_HUMAN	olfactory receptor, family 5, subfamily T,	128	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	Esophageal squamous(21;0.00448)					ATCGGATGTGCAACACAGATG	0.373			NA											12	90					0	0	0.00245	0	0
OR8J1	219477	broad.mit.edu	37	11	56127745	56127745	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr11:56127745G>T	uc010rjh.1	+	1	23	c.23G>T	c.(22-24)AGG>ATG	p.R8M		NM_001005205	NP_001005205	Q8NGP2	OR8J1_HUMAN	olfactory receptor, family 8, subfamily J,	8	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	Esophageal squamous(21;0.00448)					AATTTCACCAGAGTCACTGAG	0.453			NA											11	24					9.05144e-12	1.30675e-11	0.001855	1	0
OR5M3	219482	broad.mit.edu	37	11	56237279	56237279	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr11:56237279C>A	uc010rjk.1	-	1	695	c.695G>T	c.(694-696)AGG>ATG	p.R232M		NM_001004742	NP_001004742	Q8NGP4	OR5M3_HUMAN	olfactory receptor, family 5, subfamily M,	232	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	Esophageal squamous(21;0.00448)					GGCCTTCTGCCTTCCTTCTGC	0.443			NA											7	31					2.0095e-06	2.44928e-06	0.001984	1	0
P2RX3	5024	broad.mit.edu	37	11	57114087	57114087	+	Silent	SNP	G	G	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr11:57114087G>A	uc001nju.2	+	2	265	c.189G>A	c.(187-189)AAG>AAA	p.K63K		NM_002559	NP_002550	P56373	P2RX3_HUMAN	purinergic receptor P2X3	63	Extracellular (Potential).				positive regulation of calcium ion transport into cytosol|positive regulation of calcium-mediated signaling	integral to plasma membrane	ATP binding|extracellular ATP-gated cation channel activity|purinergic nucleotide receptor activity				0						TGGTAACCAAGGTGAAGGGCT	0.542			NA											11	34					0	0	0.001368	0	0
OR10W1	81341	broad.mit.edu	37	11	58034486	58034486	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr11:58034486G>T	uc001nmq.1	-	1	1247	c.845C>A	c.(844-846)GCC>GAC	p.A282D		NM_207374	NP_997257	Q8NGF6	O10W1_HUMAN	olfactory receptor, family 10, subfamily W,	282	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		Breast(21;0.0589)				GTTCCTCAGGGCATAGATAAG	0.537			NA											31	59					3.03874e-20	5.04309e-20	0.003271	1	0
OR5B2	390190	broad.mit.edu	37	11	58190537	58190537	+	Silent	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr11:58190537C>A	uc010rkg.1	-	1	198	c.198G>T	c.(196-198)CTG>CTT	p.L66L		NM_001005566	NP_001005566	Q96R09	OR5B2_HUMAN	olfactory receptor, family 5, subfamily B,	66	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(3)	3	Esophageal squamous(5;0.0027)	Breast(21;0.0778)				CAAAGTCCACCAGAGACAGGT	0.507			NA											28	46					8.4185e-14	1.26448e-13	0.002445	1	0
PLAC1L	219990	broad.mit.edu	37	11	59811111	59811111	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr11:59811111C>G	uc001nol.2	+	2	419	c.234C>G	c.(232-234)ATC>ATG	p.I78M		NM_173801	NP_776162	Q86WS3	PLACL_HUMAN	placenta-specific 1-like precursor	78						extracellular region				ovary(2)|skin(1)	3						ATTGTGGCATCAGGACAAGGG	0.323			NA											6	44					0	0	0.001984	0	0
MS4A3	932	broad.mit.edu	37	11	59828659	59828659	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr11:59828659C>G	uc001nom.2	+	2	154	c.26C>G	c.(25-27)GCA>GGA	p.A9G	MS4A3_uc001non.2_Missense_Mutation_p.A9G|MS4A3_uc001noo.2_Intron	NM_006138	NP_006129	Q96HJ5	MS4A3_HUMAN	membrane-spanning 4-domains, subfamily A, member	9	Cytoplasmic (Potential).					endomembrane system|integral to membrane|perinuclear region of cytoplasm	protein binding|receptor activity			ovary(2)|skin(1)	3		all_epithelial(135;0.245)				GTTGATAATGCAGAGCTGGGG	0.493			NA											19	28					0	0	0.001882	0	0
CD5	921	broad.mit.edu	37	11	60886854	60886854	+	Silent	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr11:60886854C>A	uc009ynk.2	+	5	715	c.612C>A	c.(610-612)CTC>CTA	p.L204L		NM_014207	NP_055022	P06127	CD5_HUMAN	CD5 molecule precursor	204	Extracellular (Potential).|SRCR 2.				cell proliferation|cell recognition	integral to plasma membrane	scavenger receptor activity			ovary(1)	1		all_lung(304;5.94e-05)|Lung NSC(402;7.26e-05)		BRCA - Breast invasive adenocarcinoma(625;0.000946)|Lung(977;0.0086)|LUSC - Lung squamous cell carcinoma(625;0.0528)		GCAACAACCTCCAGTGTGGCT	0.607			NA											5	47					0.00198382	0.00213454	0.001984	1	0
VWCE	220001	broad.mit.edu	37	11	61026292	61026293	+	Missense_Mutation	DNP	GG	GG	AA			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr11:61026292_61026293GG>AA	uc001nra.2	-	20	3001_3002	c.2722_2723CC>TT	c.(2722-2724)CCC>TTC	p.P908F	VWCE_uc001nrb.2_RNA	NM_152718	NP_689931	Q96DN2	VWCE_HUMAN	von Willebrand factor C and EGF domains	908						extracellular region	calcium ion binding			ovary(1)	1						GGTCTTCGAGGGGCTGGGGTCC	0.649			NA											18	35					0	0	0.004672	0	0
VWCE	220001	broad.mit.edu	37	11	61026361	61026361	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr11:61026361G>A	uc001nra.2	-	20	2933	c.2654C>T	c.(2653-2655)TCC>TTC	p.S885F	VWCE_uc001nrb.2_RNA	NM_152718	NP_689931	Q96DN2	VWCE_HUMAN	von Willebrand factor C and EGF domains	885						extracellular region	calcium ion binding			ovary(1)	1						AGGCCACCTGGACACTATCTG	0.647			NA											3	11					0	0	0.004672	0	0
FERMT3	83706	broad.mit.edu	37	11	63988070	63988070	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr11:63988070G>T	uc001nyl.2	+	12	1635	c.1486G>T	c.(1486-1488)GCC>TCC	p.A496S	FERMT3_uc001nym.2_Missense_Mutation_p.A492S	NM_178443	NP_848537	Q86UX7	URP2_HUMAN	fermitin family homolog 3 long form	496	FERM.				integrin activation|leukocyte cell-cell adhesion|platelet aggregation|regulation of cell-cell adhesion mediated by integrin	cell junction|cell projection|podosome	integrin binding			ovary(1)	1						CGGCCCTGATGCCTCTGCCGA	0.672			NA											6	5					0.00198382	0.00213454	0.001984	1	0
NPAS4	266743	broad.mit.edu	37	11	66191339	66191339	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr11:66191339G>T	uc001ohx.1	+	7	1154	c.978G>T	c.(976-978)TTG>TTT	p.L326F	NPAS4_uc010rpc.1_Missense_Mutation_p.L116F	NM_178864	NP_849195	Q8IUM7	NPAS4_HUMAN	neuronal PAS domain protein 4	326					transcription, DNA-dependent		DNA binding|signal transducer activity				0						GCCAGCAGTTGAACTCTGAAG	0.552			NA											24	48					4.59853e-10	6.34324e-10	0.005443	1	0
CCDC87	55231	broad.mit.edu	37	11	66358319	66358319	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr11:66358319C>A	uc001oiq.3	-	1	2236	c.2168G>T	c.(2167-2169)CGG>CTG	p.R723L	CCS_uc001oir.2_5'Flank	NM_018219	NP_060689	Q9NVE4	CCD87_HUMAN	coiled-coil domain containing 87	723										ovary(1)|skin(1)	2						CTTCAGGGCCCGCTCCCAGGC	0.552			NA											12	86					4.3838e-07	5.45499e-07	0.001855	1	0
MRGPRF	116535	broad.mit.edu	37	11	68777350	68777350	+	Nonsense_Mutation	SNP	C	C	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr11:68777350C>T	uc001ooo.3	-	2	387	c.20G>A	c.(19-21)TGG>TAG	p.W7*	MRGPRF_uc001oop.3_Nonsense_Mutation_p.W7*|uc001ooq.2_5'Flank	NM_001098515	NP_001091985	Q96AM1	MRGRF_HUMAN	MAS-related GPR, member F	7	Extracellular (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity				0			STAD - Stomach adenocarcinoma(18;0.0208)|LUAD - Lung adenocarcinoma(13;0.0713)			ATGGGCCTCCCAGGAGCAGTT	0.677			NA											13	38					0	0	0.004007	0	0
PDE2A	5138	broad.mit.edu	37	11	72290346	72290346	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr11:72290346G>T	uc010rrc.1	-	27	2581	c.2338C>A	c.(2338-2340)CTC>ATC	p.L780I	PDE2A_uc001oso.2_Missense_Mutation_p.L759I|PDE2A_uc010rra.1_Missense_Mutation_p.L773I|PDE2A_uc001osn.2_Missense_Mutation_p.L524I|PDE2A_uc010rrb.1_Missense_Mutation_p.L771I|PDE2A_uc010rrd.1_Missense_Mutation_p.L665I	NM_002599	NP_002590	O00408	PDE2A_HUMAN	phosphodiesterase 2A isoform 1	780	Catalytic (By similarity).				platelet activation|signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cGMP binding|cGMP-stimulated cyclic-nucleotide phosphodiesterase activity|metal ion binding			ovary(2)|breast(1)|skin(1)	4			BRCA - Breast invasive adenocarcinoma(5;3.55e-05)		Sildenafil(DB00203)|Sulindac(DB00605)	ATCTTCTGGAGGTCCTTGAAG	0.607			NA											16	80					3.51602e-12	5.14092e-12	0.008871	1	0
C2CD3	26005	broad.mit.edu	37	11	73759293	73759293	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr11:73759293C>A	uc001ouu.2	-	28	5679	c.5452G>T	c.(5452-5454)GCT>TCT	p.A1818S	C2CD3_uc001out.2_RNA	NM_015531	NP_056346	Q4AC94	C2CD3_HUMAN	C2 calcium-dependent domain containing 3	1818						centrosome				ovary(4)|pancreas(2)|skin(1)	7	Breast(11;4.16e-06)					GAGGCATGAGCAAGTTGGTCT	0.468			NA											8	13					1.76689e-08	2.32305e-08	0.006214	1	0
C11orf30	56946	broad.mit.edu	37	11	76248853	76248853	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr11:76248853G>A	uc001oxl.2	+	16	2517	c.2374G>A	c.(2374-2376)GAA>AAA	p.E792K	C11orf30_uc001oxm.2_Missense_Mutation_p.E708K|C11orf30_uc010rsb.1_Missense_Mutation_p.E807K|C11orf30_uc010rsc.1_Missense_Mutation_p.E807K|C11orf30_uc001oxn.2_Missense_Mutation_p.E793K|C11orf30_uc010rsd.1_Intron|C11orf30_uc001oxo.1_Missense_Mutation_p.E160K|C11orf30_uc010rse.1_Intron	NM_020193	NP_064578	Q7Z589	EMSY_HUMAN	EMSY protein	792					chromatin modification|DNA repair|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				ovary(5)|skin(1)	6						GGAAAAATTGGAATCTAAACC	0.393			NA											6	29					0	0	0.00308	0	0
MYO7A	4647	broad.mit.edu	37	11	76915168	76915168	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr11:76915168G>A	uc001oyb.2	+	39	5646	c.5374G>A	c.(5374-5376)GTC>ATC	p.V1792I	MYO7A_uc001oyc.2_Missense_Mutation_p.V1754I|MYO7A_uc001oye.2_RNA	NM_000260	NP_000251	Q13402	MYO7A_HUMAN	myosin VIIA isoform 1	1792	MyTH4 2.				actin filament-based movement|equilibrioception|lysosome organization|sensory perception of sound|visual perception	cytosol|lysosomal membrane|myosin complex|photoreceptor inner segment|photoreceptor outer segment|synapse	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(3)|breast(1)	4						GACACGCTCCGTCAACGAGCT	0.592			NA											3	9					0	0	0.009096	0	0
MYO7A	4647	broad.mit.edu	37	11	76922953	76922953	+	Missense_Mutation	SNP	A	A	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr11:76922953A>T	uc001oyb.2	+	46	6597	c.6325A>T	c.(6325-6327)ACC>TCC	p.T2109S	MYO7A_uc001oyc.2_Missense_Mutation_p.T2071S|MYO7A_uc001oye.2_RNA	NM_000260	NP_000251	Q13402	MYO7A_HUMAN	myosin VIIA isoform 1	2109	FERM 2.				actin filament-based movement|equilibrioception|lysosome organization|sensory perception of sound|visual perception	cytosol|lysosomal membrane|myosin complex|photoreceptor inner segment|photoreceptor outer segment|synapse	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(3)|breast(1)	4						CAAGTGGCCCACCTTTGGCTC	0.562			NA											7	24					0	0	0.00308	0	0
INTS4	92105	broad.mit.edu	37	11	77690143	77690143	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr11:77690143G>C	uc001oys.2	-	4	398	c.370C>G	c.(370-372)CAT>GAT	p.H124D	INTS4_uc001oyt.2_Intron|INTS4_uc001oyu.1_Missense_Mutation_p.H124D|INTS4_uc001oyv.1_RNA	NM_033547	NP_291025	Q96HW7	INT4_HUMAN	integrator complex subunit 4	124					snRNA processing	integrator complex	protein binding			ovary(2)	2	all_cancers(14;4.53e-19)|all_epithelial(13;1.73e-21)|Breast(9;2.71e-16)|Ovarian(111;0.152)		Epithelial(5;1.13e-46)|all cancers(3;8.92e-44)|BRCA - Breast invasive adenocarcinoma(5;8.4e-26)|OV - Ovarian serous cystadenocarcinoma(8;1.05e-23)			AGGACTTGATGAGACTCTAGA	0.378			NA											17	48					0	0	0.00499	0	0
C11orf82	220042	broad.mit.edu	37	11	82644525	82644525	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr11:82644525G>C	uc001ozt.2	+	6	2389	c.2145G>C	c.(2143-2145)GAG>GAC	p.E715D	C11orf82_uc010rsr.1_Missense_Mutation_p.E414D|C11orf82_uc010rss.1_Missense_Mutation_p.E414D|C11orf82_uc009yvd.2_Intron	NM_145018	NP_659455	Q8IXT1	NOXIN_HUMAN	nitric oxide-inducible gene protein	715					apoptosis|cell cycle arrest	cytoplasm|nucleus				ovary(2)	2						ACCCTTCAGAGTCTGATTTTT	0.373			NA											12	60					0	0	0.000978	0	0
C11orf82	220042	broad.mit.edu	37	11	82644895	82644895	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr11:82644895G>T	uc001ozt.2	+	6	2759	c.2515G>T	c.(2515-2517)GTA>TTA	p.V839L	C11orf82_uc010rsr.1_Missense_Mutation_p.V538L|C11orf82_uc010rss.1_Missense_Mutation_p.V538L|C11orf82_uc009yvd.2_Intron	NM_145018	NP_659455	Q8IXT1	NOXIN_HUMAN	nitric oxide-inducible gene protein	839					apoptosis|cell cycle arrest	cytoplasm|nucleus				ovary(2)	2						AAGCCCTATTGTATCTGGTGT	0.398			NA											3	22					0.004672	0.00493414	0.004672	1	0
CREBZF	58487	broad.mit.edu	37	11	85375702	85375702	+	Missense_Mutation	SNP	A	A	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr11:85375702A>T	uc001pas.2	-	1	481	c.218T>A	c.(217-219)GTG>GAG	p.V73E	CREBZF_uc010rtc.1_RNA|CREBZF_uc010rtd.1_RNA	NM_001039618	NP_001034707	Q9NS37	ZHANG_HUMAN	HCF-binding transcription factor Zhangfei	73					negative regulation of gene expression, epigenetic|negative regulation of transcription, DNA-dependent|regulation of sequence-specific DNA binding transcription factor activity|response to virus	nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1		Acute lymphoblastic leukemia(157;4.19e-06)|all_hematologic(158;0.0033)				GCGCACGGCCACGCCGCCGCG	0.711	NSCLC(172;674 2044 9050 18334 41735)		NA											11	41					0	0	0.000978	0	0
CCDC89	220388	broad.mit.edu	37	11	85396236	85396236	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr11:85396236C>A	uc001pau.1	-	1	1085	c.938G>T	c.(937-939)CGG>CTG	p.R313L		NM_152723	NP_689936	Q8N998	CCD89_HUMAN	coiled-coil domain containing 89	313	Potential.					cytoplasm|nucleus					0		Acute lymphoblastic leukemia(157;4.88e-06)|all_hematologic(158;0.00572)				TTGCTCAAACCGCTCCAGCGC	0.512			NA											20	33					4.35082e-09	5.82853e-09	0.010504	1	0
GRM5	2915	broad.mit.edu	37	11	88330451	88330451	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr11:88330451G>C	uc001pcq.2	-	5	1664	c.1464C>G	c.(1462-1464)GAC>GAG	p.D488E	GRM5_uc009yvm.2_Missense_Mutation_p.D488E	NM_001143831	NP_001137303	P41594	GRM5_HUMAN	glutamate receptor, metabotropic 5 isoform a	488	Extracellular (Potential).				activation of phospholipase C activity by metabotropic glutamate receptor signaling pathway|synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			central_nervous_system(4)|ovary(2)|lung(2)|breast(1)	9		Acute lymphoblastic leukemia(157;2.54e-05)|all_hematologic(158;0.00834)			Acamprosate(DB00659)	ATTCTCCATTGTCCCAACTTC	0.353			NA											8	20					0	0	0.006214	0	0
FAT3	120114	broad.mit.edu	37	11	92533858	92533858	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr11:92533858G>T	uc001pdj.3	+	9	7696	c.7679G>T	c.(7678-7680)CGG>CTG	p.R2560L		NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	2560	Cadherin 23.|Extracellular (Potential).				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				AGGCTAGACCGGGAAAACCCT	0.473			NA								TCGA Ovarian(4;0.039)			4	22					5.9392e-07	7.35353e-07	0.001168	1	0
FAT3	120114	broad.mit.edu	37	11	92590415	92590415	+	Nonsense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr11:92590415G>T	uc001pdj.3	+	19	11418	c.11401G>T	c.(11401-11403)GAG>TAG	p.E3801*	FAT3_uc001pdi.3_Nonsense_Mutation_p.E241*	NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	3801	EGF-like 1.|Extracellular (Potential).				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				TCCTTGTGTGGAGAAGCCGTG	0.557			NA								TCGA Ovarian(4;0.039)			20	31					8.10497e-08	1.03987e-07	0.010504	1	0
CEP57	9702	broad.mit.edu	37	11	95555060	95555060	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr11:95555060G>C	uc001pfp.1	+	7	946	c.725G>C	c.(724-726)AGA>ACA	p.R242T	CEP57_uc001pfo.1_Missense_Mutation_p.R242T|CEP57_uc010ruh.1_Missense_Mutation_p.R233T|CEP57_uc010rui.1_Missense_Mutation_p.R242T|CEP57_uc009ywn.1_Missense_Mutation_p.R90T|CEP57_uc001pfq.1_Missense_Mutation_p.R242T|CEP57_uc001pfr.1_Missense_Mutation_p.R90T	NM_014679	NP_055494	Q86XR8	CEP57_HUMAN	translokin	242	Potential.				fibroblast growth factor receptor signaling pathway|G2/M transition of mitotic cell cycle|protein import into nucleus, translocation|spermatid development	centrosome|cytosol|Golgi apparatus|microtubule|nucleus	fibroblast growth factor binding|protein homodimerization activity			ovary(1)	1		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)				GAAACAAATAGACTTATCTTT	0.363			NA							Mosaic_Variegated_Aneuploidy_Syndrome				9	13					0	0	0.008291	0	0
MMP27	64066	broad.mit.edu	37	11	102562575	102562575	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr11:102562575C>G	uc001phd.1	-	10	1487	c.1464G>C	c.(1462-1464)AAG>AAC	p.K488N		NM_022122	NP_071405	Q9H306	MMP27_HUMAN	matrix metalloproteinase 27 precursor	488					collagen catabolic process|proteolysis	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			ovary(2)|skin(1)	3	all_cancers(8;0.000843)|all_epithelial(12;0.00362)|Lung NSC(15;0.21)	all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)	Epithelial(9;0.0509)|Lung(13;0.0696)|LUSC - Lung squamous cell carcinoma(19;0.13)|all cancers(10;0.176)	BRCA - Breast invasive adenocarcinoma(274;0.0151)		GATACAATATCTTTATGCCTC	0.299			NA											15	25					0	0	0.004007	0	0
MMP3	4314	broad.mit.edu	37	11	102709892	102709892	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr11:102709892C>A	uc001phj.1	-	7	1083	c.1018G>T	c.(1018-1020)GTG>TTG	p.V340L		NM_002422	NP_002413	P08254	MMP3_HUMAN	matrix metalloproteinase 3 preproprotein	340	Hemopexin-like 2.				collagen catabolic process|proteolysis	extracellular space|proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			lung(1)|kidney(1)	2		all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)		BRCA - Breast invasive adenocarcinoma(274;0.0142)	Marimastat(DB00786)|Simvastatin(DB00641)	GCGGCATCCACGCCTGAAGGA	0.378			NA											13	49					4.75885e-15	7.35593e-15	0.00499	1	0
MMP3	4314	broad.mit.edu	37	11	102712964	102712964	+	Silent	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr11:102712964G>T	uc001phj.1	-	4	611	c.546C>A	c.(544-546)GCC>GCA	p.A182A		NM_002422	NP_002413	P08254	MMP3_HUMAN	matrix metalloproteinase 3 preproprotein	182					collagen catabolic process|proteolysis	extracellular space|proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			lung(1)|kidney(1)	2		all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)		BRCA - Breast invasive adenocarcinoma(274;0.0142)	Marimastat(DB00786)|Simvastatin(DB00641)	CATAGGCATGGGCCAAAACAT	0.418			NA											13	29					0.00316338	0.003372	0.003163	1	0
GRIA4	2893	broad.mit.edu	37	11	105850454	105850454	+	Silent	SNP	G	G	C			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr11:105850454G>C	uc001pix.2	+	17	3143	c.2697G>C	c.(2695-2697)TCG>TCC	p.S899S	GRIA4_uc001piw.2_3'UTR|GRIA4_uc009yxl.1_RNA	NM_000829	NP_000820	P48058	GRIA4_HUMAN	glutamate receptor, ionotrophic, AMPA 4 isoform	899	Cytoplasmic (Potential).				glutamate signaling pathway|synaptic transmission	cell junction|endocytic vesicle membrane|integral to membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity			ovary(3)|skin(3)|lung(1)|central_nervous_system(1)	8		Melanoma(852;0.000902)|Acute lymphoblastic leukemia(157;0.000994)|all_hematologic(158;0.0017)|Breast(348;0.0323)		BRCA - Breast invasive adenocarcinoma(274;0.000147)|Epithelial(105;0.0291)|all cancers(92;0.0899)	L-Glutamic Acid(DB00142)	TCATTGCATCGGACCTACCAT	0.502			NA											5	14					0	0	0.001168	0	0
EXPH5	23086	broad.mit.edu	37	11	108382214	108382214	+	Silent	SNP	T	T	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr11:108382214T>A	uc001pkk.2	-	6	4131	c.4020A>T	c.(4018-4020)CTA>CTT	p.L1340L	EXPH5_uc010rvy.1_Silent_p.L1152L|EXPH5_uc010rvz.1_Silent_p.L1184L|EXPH5_uc010rwa.1_Silent_p.L1264L	NM_015065	NP_055880	Q8NEV8	EXPH5_HUMAN	exophilin 5 isoform a	1340					intracellular protein transport		Rab GTPase binding			skin(3)|ovary(2)	5		all_cancers(61;3.99e-08)|Acute lymphoblastic leukemia(157;3.97e-05)|Melanoma(852;4.04e-05)|all_epithelial(67;0.000116)|all_hematologic(158;0.000315)|Breast(348;0.104)|all_neural(303;0.16)		Epithelial(105;8.1e-06)|BRCA - Breast invasive adenocarcinoma(274;1.22e-05)|all cancers(92;0.000129)|OV - Ovarian serous cystadenocarcinoma(223;0.11)|Colorectal(284;0.184)		ATGTAGGAGCTAGGGGCCCCC	0.413			NA											12	17					0	0	0.004007	0	0
ZW10	9183	broad.mit.edu	37	11	113644334	113644334	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr11:113644334C>A	uc001poe.2	-	1	92	c.55G>T	c.(55-57)GAT>TAT	p.D19Y	ZW10_uc009yyv.2_RNA	NM_004724	NP_004715	O43264	ZW10_HUMAN	centromere/kinetochore protein zw10	19	Interaction with RINT1.|Interaction with ZWINT.|Potential.				cell division|ER to Golgi vesicle-mediated transport|establishment of mitotic spindle orientation|meiosis|mitotic cell cycle checkpoint|mitotic metaphase plate congression|mitotic prometaphase|protein complex assembly|protein localization to kinetochore|protein transport|regulation of exit from mitosis	condensed chromosome kinetochore|cytosol|endoplasmic reticulum membrane|kinetochore microtubule|nucleus|spindle pole	centromeric DNA binding|protein binding			central_nervous_system(1)|skin(1)	2		all_cancers(61;3.84e-16)|all_epithelial(67;1e-09)|Melanoma(852;1.46e-05)|all_hematologic(158;0.000237)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0101)|all_neural(223;0.0281)|Prostate(24;0.0421)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;2.94e-06)|Epithelial(105;0.000103)|all cancers(92;0.000786)		GTCCCCAGATCCTCCTTTTCC	0.632			NA											10	59					6.42651e-13	9.55622e-13	0.000978	1	0
BUD13	84811	broad.mit.edu	37	11	116628652	116628652	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr11:116628652C>A	uc001ppn.2	-	8	1548	c.1514G>T	c.(1513-1515)CGG>CTG	p.R505L	BUD13_uc001ppo.2_Missense_Mutation_p.R371L	NM_032725	NP_116114	Q9BRD0	BUD13_HUMAN	BUD13 homolog isoform 1	505	Potential.									large_intestine(1)|pancreas(1)	2	all_hematologic(175;0.0487)	all_cancers(61;1.72e-06)|all_epithelial(67;0.000735)|Melanoma(852;0.022)|Acute lymphoblastic leukemia(157;0.0255)|Medulloblastoma(222;0.0523)|Breast(348;0.056)|all_hematologic(158;0.0588)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|Epithelial(105;5.81e-06)|all cancers(92;0.000144)|OV - Ovarian serous cystadenocarcinoma(223;0.154)		TTGCTGTTGCCGGCTCTGGGC	0.468			NA											16	25					2.35188e-11	3.34985e-11	0.006122	1	0
CEP164	22897	broad.mit.edu	37	11	117242165	117242165	+	Missense_Mutation	SNP	A	A	G			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr11:117242165A>G	uc001prc.2	+	9	1282	c.1135A>G	c.(1135-1137)AGT>GGT	p.S379G	CEP164_uc001prb.2_Missense_Mutation_p.S379G|CEP164_uc010rxk.1_Missense_Mutation_p.S353G|CEP164_uc001prf.2_RNA|CEP164_uc009yzp.1_RNA	NM_014956	NP_055771	Q9UPV0	CE164_HUMAN	centrosomal protein 164kDa	379					cell division|DNA repair|G2/M transition of mitotic cell cycle|mitosis	centriole|cytosol|nucleus				ovary(1)|central_nervous_system(1)	2	all_hematologic(175;0.0487)	Breast(348;0.00908)|Medulloblastoma(222;0.0425)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;4e-05)|Epithelial(105;0.0008)		GGAAGAGGGCAGTTCAGACGC	0.582			NA											15	32					0	0	0.006122	0	0
DSCAML1	57453	broad.mit.edu	37	11	117389215	117389215	+	Silent	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr11:117389215G>T	uc001prh.1	-	7	1658	c.1656C>A	c.(1654-1656)GGC>GGA	p.G552G	DSCAML1_uc001pri.1_Silent_p.G356G	NM_020693	NP_065744	Q8TD84	DSCL1_HUMAN	Down syndrome cell adhesion molecule like 1	492	Extracellular (Potential).|Ig-like C2-type 5.				axonogenesis|brain development|cell fate determination|dorsal/ventral pattern formation|embryonic skeletal system morphogenesis|homophilic cell adhesion	cell surface|integral to membrane|plasma membrane	protein homodimerization activity			ovary(3)|large_intestine(2)|skin(2)|upper_aerodigestive_tract(1)	8	all_hematologic(175;0.0487)	Breast(348;0.0424)|Medulloblastoma(222;0.0523)|all_hematologic(192;0.232)		BRCA - Breast invasive adenocarcinoma(274;9.12e-06)|Epithelial(105;0.00172)		ATTCAGCACTGCCCACCAAGT	0.532			NA											16	84					4.96729e-08	6.42292e-08	0.008871	1	0
AMICA1	120425	broad.mit.edu	37	11	118083145	118083145	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr11:118083145G>C	uc001psk.2	-	3	349	c.175C>G	c.(175-177)CTG>GTG	p.L59V	AMICA1_uc001psh.2_Missense_Mutation_p.L20V|AMICA1_uc009yzw.1_RNA|AMICA1_uc001psi.2_Missense_Mutation_p.L49V|AMICA1_uc001psj.2_Missense_Mutation_p.L59V|AMICA1_uc010rxw.1_Missense_Mutation_p.L20V|AMICA1_uc010rxx.1_Missense_Mutation_p.L59V|AMICA1_uc001psl.1_Missense_Mutation_p.L15V	NM_001098526	NP_001091996	Q86YT9	JAML1_HUMAN	adhesion molecule, interacts with CXADR antigen	59	Ig-like V-type 1.|Extracellular (Potential).				blood coagulation|cell adhesion|leukocyte migration|regulation of immune response	cell junction|integral to membrane				ovary(1)	1	all_hematologic(175;0.046)	Medulloblastoma(222;0.0425)|Breast(348;0.181)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;3.4e-05)		CCTGGTGACAGAGTCCAGTCT	0.502			NA											22	61					0	0	0.00632	0	0
TRIM29	23650	broad.mit.edu	37	11	120008148	120008148	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr11:120008148G>A	uc001pwz.2	-	1	716	c.592C>T	c.(592-594)CAT>TAT	p.H198Y	TRIM29_uc001pxa.2_RNA	NM_012101	NP_036233	Q14134	TRI29_HUMAN	tripartite motif protein TRIM29	198					transcription from RNA polymerase II promoter	cytoplasm	protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|breast(1)|kidney(1)|skin(1)	4		Breast(109;0.00117)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;5.37e-06)		GGCTTGAGATGCAGCTCGCAG	0.652			NA											9	17					0	0	0.008291	0	0
OAF	220323	broad.mit.edu	37	11	120097704	120097704	+	Missense_Mutation	SNP	A	A	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr11:120097704A>T	uc001pxb.2	+	3	787	c.546A>T	c.(544-546)CAA>CAT	p.Q182H		NM_178507	NP_848602	Q86UD1	OAF_HUMAN	OAF homolog precursor	182											0		Breast(109;0.00663)|Medulloblastoma(222;0.0523)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;5.1e-06)		GGCTGGAGCAAGGTCAGCTGG	0.662			NA											9	11					0	0	0.000978	0	0
GRIK4	2900	broad.mit.edu	37	11	120827647	120827647	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr11:120827647G>T	uc001pxn.2	+	16	2146	c.1859G>T	c.(1858-1860)TGT>TTT	p.C620F	GRIK4_uc009zav.1_Missense_Mutation_p.C620F|GRIK4_uc009zaw.1_Missense_Mutation_p.C620F|GRIK4_uc009zax.1_Missense_Mutation_p.C620F	NM_014619	NP_055434	Q16099	GRIK4_HUMAN	glutamate receptor KA1 precursor	620	Cytoplasmic (Potential).				glutamate signaling pathway|synaptic transmission	cell junction|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			ovary(2)|central_nervous_system(1)	3		Breast(109;0.000868)|Medulloblastoma(222;0.0453)|all_neural(223;0.116)|all_hematologic(192;0.21)		BRCA - Breast invasive adenocarcinoma(274;1.24e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.116)	L-Glutamic Acid(DB00142)	TCCACCCGCTGTGTCAGTGGC	0.627			NA											5	14					1.024e-07	1.31153e-07	0.000602	1	0
GRIK4	2900	broad.mit.edu	37	11	120852872	120852872	+	Missense_Mutation	SNP	T	T	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr11:120852872T>A	uc001pxn.2	+	20	2740	c.2453T>A	c.(2452-2454)GTG>GAG	p.V818E	GRIK4_uc009zaw.1_Missense_Mutation_p.V818E|GRIK4_uc009zax.1_Missense_Mutation_p.V818E	NM_014619	NP_055434	Q16099	GRIK4_HUMAN	glutamate receptor KA1 precursor	818	Helical; (Potential).				glutamate signaling pathway|synaptic transmission	cell junction|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			ovary(2)|central_nervous_system(1)	3		Breast(109;0.000868)|Medulloblastoma(222;0.0453)|all_neural(223;0.116)|all_hematologic(192;0.21)		BRCA - Breast invasive adenocarcinoma(274;1.24e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.116)	L-Glutamic Acid(DB00142)	GGCTTAATCGTGGCCATTTTT	0.383			NA											31	75					0	0	0.003271	0	0
SCN3B	55800	broad.mit.edu	37	11	123508911	123508911	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr11:123508911C>A	uc001pza.1	-	5	974	c.567G>T	c.(565-567)GAG>GAT	p.E189D	SCN3B_uc001pzb.1_Missense_Mutation_p.E189D	NM_001040151	NP_001035241	Q9NY72	SCN3B_HUMAN	voltage-gated sodium channel beta-3 subunit	189	Cytoplasmic (Potential).				axon guidance	integral to membrane|plasma membrane	voltage-gated sodium channel activity			large_intestine(2)|ovary(2)|central_nervous_system(1)|skin(1)	6		Breast(109;0.00204)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;5.37e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0227)		CTTGGGCTGCCTCTTCGGCTT	0.323			NA											6	18					2.0095e-06	2.44928e-06	0.001984	1	0
OR10G8	219869	broad.mit.edu	37	11	123900510	123900510	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr11:123900510C>T	uc001pzp.1	+	1	181	c.181C>T	c.(181-183)CTC>TTC	p.L61F		NM_001004464	NP_001004464	Q8NGN5	O10G8_HUMAN	olfactory receptor, family 10, subfamily G,	61	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0521)		GTACTACTTCCTCACCAACCT	0.527			NA											18	112					0	0	0.008871	0	0
CCDC15	80071	broad.mit.edu	37	11	124847487	124847487	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr11:124847487G>T	uc001qbm.3	+	6	1003	c.744G>T	c.(742-744)ATG>ATT	p.M248I		NM_025004	NP_079280	Q0P6D6	CCD15_HUMAN	coiled-coil domain containing 15	248						centrosome				ovary(1)|central_nervous_system(1)	2	all_hematologic(175;0.215)	Breast(109;0.00222)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.68e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0413)		AGAATTATATGGAAAATCAGG	0.398			NA											5	9					3.59834e-05	4.13823e-05	0.001168	1	0
SPATA19	219938	broad.mit.edu	37	11	133714491	133714491	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr11:133714491G>C	uc001qgv.1	-	3	231	c.180C>G	c.(178-180)ATC>ATG	p.I60M		NM_174927	NP_777587	Q7Z5L4	SPT19_HUMAN	spermatogenesis associated 19 precursor	60					cell differentiation|multicellular organismal development|spermatogenesis	mitochondrial outer membrane					0	all_hematologic(175;0.127)	all_cancers(12;5.59e-17)|all_epithelial(12;2.65e-12)|all_lung(97;0.00045)|Lung NSC(97;0.000861)|Breast(109;0.000873)|Medulloblastoma(222;0.0425)|Esophageal squamous(93;0.0844)|all_neural(223;0.117)		Epithelial(10;4.36e-10)|all cancers(11;7.1e-09)|BRCA - Breast invasive adenocarcinoma(10;8.45e-09)|OV - Ovarian serous cystadenocarcinoma(99;0.00286)|Lung(977;0.207)		AAGGGTGGTTGATGGACAGCT	0.512			NA											5	56					0	0	0.000602	0	0
IGSF9B	22997	broad.mit.edu	37	11	133790145	133790145	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr11:133790145C>T	uc001qgx.3	-	18	3706	c.3475G>A	c.(3475-3477)GGC>AGC	p.G1159S		NM_014987	NP_055802	Q9UPX0	TUTLB_HUMAN	immunoglobulin superfamily, member 9B	1159	Pro-rich.|Cytoplasmic (Potential).					integral to membrane|plasma membrane					0	all_hematologic(175;0.127)	all_cancers(12;1.58e-21)|all_epithelial(12;5.17e-16)|all_lung(97;1.6e-05)|Lung NSC(97;3.86e-05)|Breast(109;0.000126)|Medulloblastoma(222;0.0245)|all_neural(223;0.0505)|Esophageal squamous(93;0.0559)		Epithelial(10;7.19e-10)|BRCA - Breast invasive adenocarcinoma(10;9.69e-09)|all cancers(11;1.23e-08)|OV - Ovarian serous cystadenocarcinoma(99;0.00328)|Lung(977;0.221)		CTGGGGCCGCCGTGCGCCCCC	0.682			NA											10	39					0	0	0.001855	0	0
CACNA1C	775	broad.mit.edu	37	12	2800282	2800282	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr12:2800282G>A	uc009zdu.1	+	50	6896	c.6583G>A	c.(6583-6585)GAG>AAG	p.E2195K	CACNA1C_uc009zdv.1_Missense_Mutation_p.E2109K|CACNA1C_uc001qkb.2_Missense_Mutation_p.E2112K|CACNA1C_uc001qkc.2_Missense_Mutation_p.E2131K|CACNA1C_uc001qke.2_Missense_Mutation_p.E2101K|CACNA1C_uc001qkf.2_Missense_Mutation_p.E2120K|CACNA1C_uc001qjz.2_Missense_Mutation_p.E2112K|CACNA1C_uc001qkd.2_Missense_Mutation_p.E2131K|CACNA1C_uc001qkg.2_Missense_Mutation_p.E2118K|CACNA1C_uc009zdw.1_Missense_Mutation_p.E2153K|CACNA1C_uc001qkh.2_Missense_Mutation_p.E2120K|CACNA1C_uc001qkl.2_Missense_Mutation_p.E2160K|CACNA1C_uc001qkn.2_Missense_Mutation_p.E2112K|CACNA1C_uc001qko.2_Missense_Mutation_p.E2132K|CACNA1C_uc001qkp.2_Missense_Mutation_p.E2112K|CACNA1C_uc001qkr.2_Missense_Mutation_p.E2129K|CACNA1C_uc001qku.2_Missense_Mutation_p.E2147K|CACNA1C_uc001qkq.2_Missense_Mutation_p.E2140K|CACNA1C_uc001qks.2_Missense_Mutation_p.E2112K|CACNA1C_uc001qkt.2_Missense_Mutation_p.E2131K|CACNA1C_uc001qki.1_Missense_Mutation_p.E1919K|CACNA1C_uc001qkj.1_Missense_Mutation_p.E1883K|CACNA1C_uc001qkk.1_Missense_Mutation_p.E1848K|CACNA1C_uc001qkm.1_Missense_Mutation_p.E1908K|CACNA1C_uc010sea.1_Missense_Mutation_p.E803K|uc001qkx.1_RNA|CACNA1C_uc001qky.1_Missense_Mutation_p.E430K	NM_199460	NP_955630	Q13936	CAC1C_HUMAN	calcium channel, voltage-dependent, L type,	2195	Cytoplasmic (Potential).				axon guidance|calcium ion transport into cytosol|energy reserve metabolic process|regulation of insulin secretion	cytoplasm|postsynaptic density|voltage-gated calcium channel complex	calmodulin binding|voltage-gated calcium channel activity			ovary(10)|central_nervous_system(1)	11			OV - Ovarian serous cystadenocarcinoma(31;0.00256)	LUAD - Lung adenocarcinoma(1;0.134)	Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Nicardipine(DB00622)|Verapamil(DB00661)	CGGGGGCGAAGAGGACGCGGG	0.692			NA											15	11					0	0	0.006122	0	0
CCND2	894	broad.mit.edu	37	12	4385191	4385191	+	Nonsense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr12:4385191C>A	uc001qmo.2	+	2	521	c.216C>A	c.(214-216)TGC>TGA	p.C72*		NM_001759	NP_001750	P30279	CCND2_HUMAN	cyclin D2	72	Cyclin N-terminal.				cell division|positive regulation of cyclin-dependent protein kinase activity|positive regulation of protein phosphorylation	cyclin-dependent protein kinase holoenzyme complex|cytoplasm|membrane|nucleus	protein kinase binding			haematopoietic_and_lymphoid_tissue(1)|breast(1)|kidney(1)	3			all cancers(3;4.15e-10)|GBM - Glioblastoma multiforme(3;6.34e-05)|Colorectal(7;0.00245)|OV - Ovarian serous cystadenocarcinoma(31;0.00301)|COAD - Colon adenocarcinoma(12;0.0264)|STAD - Stomach adenocarcinoma(119;0.206)			AACAGAAGTGCGAAGAAGAGG	0.532			NA	T	IGL@	NHL,CLL								9	70					1.08611e-07	1.38156e-07	0.000978	1	0
C12orf4	57102	broad.mit.edu	37	12	4598990	4598990	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr12:4598990G>C	uc001qms.2	-	14	1730	c.1642C>G	c.(1642-1644)CTG>GTG	p.L548V	C12orf4_uc001qmt.2_Missense_Mutation_p.L548V	NM_020374	NP_065107	Q9NQ89	CL004_HUMAN	hypothetical protein LOC57102	548											0			Colorectal(7;0.00165)|COAD - Colon adenocarcinoma(12;0.0229)	BRCA - Breast invasive adenocarcinoma(232;0.0281)		TTGGATGTCAGAGTGAGTGTT	0.378			NA											47	65					0	0	0.00361	0	0
NTF3	4908	broad.mit.edu	37	12	5604066	5604066	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr12:5604066C>T	uc001qnl.3	+	1	769	c.686C>T	c.(685-687)TCA>TTA	p.S229L	NTF3_uc001qnk.3_Missense_Mutation_p.S242L	NM_002527	NP_002518	P20783	NTF3_HUMAN	neurotrophin 3 isoform 2 preproprotein	229					signal transduction	extracellular region	growth factor activity|neurotrophin receptor binding			pancreas(1)	1						GCACTGACTTCAGAGAACAAT	0.488	GBM(194;1104 2182 8339 9578 18493)		NA											8	41					0	0	0.006214	0	0
CD9	928	broad.mit.edu	37	12	6344465	6344465	+	Missense_Mutation	SNP	G	G	T	rs35799798	byFrequency	TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr12:6344465G>T	uc001qnp.1	+	6	863	c.419G>T	c.(418-420)CGG>CTG	p.R140L	CD9_uc010sev.1_Missense_Mutation_p.R140L|CD9_uc001qnq.1_Missense_Mutation_p.R140L	NM_001769	NP_001760	P21926	CD9_HUMAN	CD9 antigen	140	Extracellular (Potential).				cell adhesion|cellular component movement|fusion of sperm to egg plasma membrane|paranodal junction assembly|platelet activation|platelet degranulation	integral to plasma membrane|platelet alpha granule membrane				ovary(1)	1						GAGCCCCAGCGGGAAACGCTG	0.537			NA											31	46					1.61788e-16	2.57855e-16	0.002445	1	0
CD4	920	broad.mit.edu	37	12	6925297	6925297	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr12:6925297C>A	uc001qqv.1	+	6	928	c.683C>A	c.(682-684)ACA>AAA	p.T228K	CD4_uc009zez.1_3'UTR|CD4_uc009zfa.1_RNA|CD4_uc009zfb.1_RNA|CD4_uc010sfj.1_5'UTR|CD4_uc009zfc.1_Missense_Mutation_p.T49K|CD4_uc010sfk.1_5'UTR|CD4_uc010sfl.1_5'UTR|CD4_uc010sfm.1_5'UTR	NM_000616	NP_000607	P01730	CD4_HUMAN	CD4 antigen precursor	228	Extracellular (Potential).|Ig-like C2-type 2.				cell adhesion|entry into host cell|immune response|induction by virus of host cell-cell fusion|initiation of viral infection|maintenance of protein location in cell|positive regulation of interleukin-2 biosynthetic process|positive regulation of protein kinase activity|protein palmitoleylation|regulation of defense response to virus by virus|T cell costimulation|T cell receptor signaling pathway|T cell selection|transmembrane receptor protein tyrosine kinase signaling pathway	early endosome|endoplasmic reticulum membrane|integral to membrane|T cell receptor complex	coreceptor activity|extracellular matrix structural constituent|glycoprotein binding|MHC class II protein binding|protein homodimerization activity|protein kinase binding|transmembrane receptor activity|zinc ion binding				0		Myeloproliferative disorder(1001;0.0122)				CTCGCCTTTACAGTTGAAAAG	0.552			NA											15	91					1.15088e-07	1.4602e-07	0.004007	1	0
SLC2A3	6515	broad.mit.edu	37	12	8075439	8075439	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr12:8075439C>A	uc001qtr.2	-	9	1512	c.1250G>T	c.(1249-1251)GGA>GTA	p.G417V		NM_006931	NP_008862	P11169	GTR3_HUMAN	solute carrier family 2 (facilitated glucose	417	Helical; Name=11; (Potential).				carbohydrate metabolic process|water-soluble vitamin metabolic process	integral to membrane|plasma membrane	D-glucose transmembrane transporter activity|dehydroascorbic acid transporter activity			ovary(3)|pancreas(1)	4				Kidney(36;0.0866)		GAAGAGCAATCCGACTAGGAA	0.512	Colon(96;424 1461 14416 20933 23688)		NA											26	38					8.4185e-14	1.26448e-13	0.002445	1	0
PZP	5858	broad.mit.edu	37	12	9312562	9312562	+	Nonsense_Mutation	SNP	G	G	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr12:9312562G>A	uc001qvl.2	-	25	3138	c.3109C>T	c.(3109-3111)CGA>TGA	p.R1037*	PZP_uc009zgl.2_Nonsense_Mutation_p.R823*	NM_002864	NP_002855			pregnancy-zone protein precursor											ovary(3)|upper_aerodigestive_tract(1)|large_intestine(1)	5						CTGCCATATCGTTCCCCAAAG	0.403	Melanoma(125;1402 1695 4685 34487 38571)		NA											41	80					0	0	0.00361	0	0
DDX12	440081	broad.mit.edu	37	12	9577158	9577158	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr12:9577158C>A	uc010sgs.1	-	18	2036	c.1841G>T	c.(1840-1842)CGG>CTG	p.R614L		NM_004400	NP_004391			DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 12												0						GACCACTGCCCGGCATTCCTT	0.572			NA											8	49					1.12685e-05	1.32356e-05	0.004482	1	0
OLR1	4973	broad.mit.edu	37	12	10319353	10319353	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr12:10319353G>C	uc001qxo.1	-	3	496	c.382C>G	c.(382-384)CTG>GTG	p.L128V	OLR1_uc010sgz.1_Missense_Mutation_p.L24V|OLR1_uc010sha.1_Missense_Mutation_p.L128V	NM_002543	NP_002534	P78380	OLR1_HUMAN	oxidized low density lipoprotein (lectin-like)	128	Extracellular (Potential).|Neck.				blood circulation|blood coagulation|inflammatory response|leukocyte migration|proteolysis	extracellular region|integral to plasma membrane|membrane fraction	sugar binding			ovary(1)	1						TGGAGATTCAGATTCTGGTGG	0.423			NA											30	62					0	0	0.002445	0	0
TAS2R7	50837	broad.mit.edu	37	12	10955157	10955157	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr12:10955157C>A	uc001qyv.2	-	1	70	c.13G>T	c.(13-15)GTG>TTG	p.V5L		NM_023919	NP_076408	Q9NYW3	TA2R7_HUMAN	taste receptor, type 2, member 7	5	Extracellular (Potential).				sensory perception of taste	integral to membrane	taste receptor activity			skin(1)	1						GTAGTCTGCACTTTATCTGCC	0.383			NA											13	140					0.00185496	0.00200605	0.001855	1	0
PRB1	5542	broad.mit.edu	37	12	11506604	11506604	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr12:11506604C>T	uc001qzw.1	-	3	470	c.433G>A	c.(433-435)GGA>AGA	p.G145R	PRB1_uc001qzu.1_Intron|PRB1_uc001qzv.1_Intron	NM_005039	NP_005030	P04280	PRP1_HUMAN	proline-rich protein BstNI subfamily 1 isoform 1	206	15 X 20 AA approximate tandem repeats of P-P-G-K-P-Q-G-P-P-[PAQ]-Q-[GE]-[GD]- [NKS]-[KSQRN]-[PRQS]-[QS] [GPS]-[PQAR]- [PSR].|8.		Missing (in clone CP-4).|Missing (in clone CP-5).|Missing (in allele S).			extracellular region					0			OV - Ovarian serous cystadenocarcinoma(49;0.185)			GACTTGTCTCCTTGTGGGGGT	0.607			NA											12	118					0	0	0.002096	0	0
PRB2	653247	broad.mit.edu	37	12	11546699	11546699	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr12:11546699C>T	uc010shk.1	-	3	348	c.313G>A	c.(313-315)GGA>AGA	p.G105R		NM_006248	NP_006239			proline-rich protein BstNI subfamily 2												0		all_cancers(2;0.00558)|Acute lymphoblastic leukemia(2;3.94e-11)|all_hematologic(2;3.6e-09)	OV - Ovarian serous cystadenocarcinoma(49;0.185)			GACTTGTCTCCTTGTGGGGGT	0.607			NA											61	494					0	0	0.00361	0	0
GPRC5A	9052	broad.mit.edu	37	12	13061883	13061883	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr12:13061883C>T	uc001rba.2	+	2	1350	c.700C>T	c.(700-702)CCT>TCT	p.P234S	GPRC5A_uc001raz.2_Missense_Mutation_p.P234S	NM_003979	NP_003970	Q8NFJ5	RAI3_HUMAN	G protein-coupled receptor, family C, group 5,	234	Extracellular (Potential).					cytoplasmic vesicle membrane|Golgi apparatus|integral to plasma membrane	G-protein coupled receptor activity				0		Prostate(47;0.141)		BRCA - Breast invasive adenocarcinoma(232;0.0708)	Tretinoin(DB00755)	GCTCATGCTTCCTGACTTTGA	0.572			NA											33	46					0	0	0.002445	0	0
PIK3C2G	5288	broad.mit.edu	37	12	18446839	18446839	+	Missense_Mutation	SNP	T	T	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr12:18446839T>A	uc001rdt.2	+	5	1040	c.924T>A	c.(922-924)AAT>AAA	p.N308K	PIK3C2G_uc010sia.1_RNA|PIK3C2G_uc010sib.1_Missense_Mutation_p.N308K|PIK3C2G_uc010sic.1_Missense_Mutation_p.N86K	NM_004570	NP_004561	O75747	P3C2G_HUMAN	phosphoinositide-3-kinase, class 2 gamma	308					cell communication|phosphatidylinositol-mediated signaling	membrane|phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity			lung(8)|central_nervous_system(6)|breast(3)|stomach(2)|ovary(2)	21		Hepatocellular(102;0.194)				CTTTAGCTAATTATCTTGTCA	0.313			NA											7	8					0	0	0.00308	0	0
SLCO1C1	53919	broad.mit.edu	37	12	20868121	20868121	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr12:20868121G>C	uc001rej.3	+	7	933	c.578G>C	c.(577-579)GGC>GCC	p.G193A	SLCO1C1_uc010sii.1_Missense_Mutation_p.G193A|SLCO1C1_uc010sij.1_Intron|SLCO1C1_uc009zip.2_Missense_Mutation_p.G27A|SLCO1C1_uc001rei.2_Missense_Mutation_p.G193A|SLCO1C1_uc010sik.1_Missense_Mutation_p.G75A	NM_017435	NP_059131	Q9NYB5	SO1C1_HUMAN	solute carrier organic anion transporter family,	193	Helical; Name=4; (Potential).				sodium-independent organic anion transport	integral to membrane|plasma membrane	thyroid hormone transmembrane transporter activity			ovary(5)|pancreas(1)|skin(1)	7	Esophageal squamous(101;0.149)					GTTTTCCTGGGCAATCTTCTT	0.403			NA											50	91					0	0	0.00361	0	0
SLCO1B1	10599	broad.mit.edu	37	12	21355454	21355455	+	Missense_Mutation	DNP	GG	GG	TT			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr12:21355454_21355455GG>TT	uc001req.3	+	10	1269_1270	c.1165_1166GG>TT	c.(1165-1167)GGA>TTA	p.G389L		NM_006446	NP_006437	Q9Y6L6	SO1B1_HUMAN	solute carrier organic anion transporter family,	389	Helical; Name=8; (Potential).				bile acid metabolic process|sodium-independent organic anion transport	basolateral plasma membrane|integral to plasma membrane|membrane fraction	bile acid transmembrane transporter activity|sodium-independent organic anion transmembrane transporter activity|thyroid hormone transmembrane transporter activity			ovary(3)|skin(3)|pancreas(1)|central_nervous_system(1)	8					Digoxin(DB00390)|Gemfibrozil(DB01241)|Pravastatin(DB00175)	TTTTGCAAGTGGAATGTTTTTA	0.297			NA											6	24					0	0	0.004672	0	0
KRAS	3845	broad.mit.edu	37	12	25398285	25398285	+	Missense_Mutation	SNP	C	C	A	rs121913530		TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr12:25398285C>A	uc001rgp.1	-	2	215	c.34G>T	c.(34-36)GGT>TGT	p.G12C	KRAS_uc001rgq.1_Missense_Mutation_p.G12C|KRAS_uc001rgr.2_RNA	NM_033360	NP_203524	P01116	RASK_HUMAN	c-K-ras2 protein isoform a precursor	12	GTP.		G -> D (in pancreatic carcinoma, GASC and lung carcinoma; somatic mutation).|G -> R (in lung cancer and bladder cancer; somatic mutation).|G -> S (in lung carcinoma and GASC; somatic mutation).|G -> A (in a colorectal cancer sample; somatic mutation).|G -> C (in lung carcinoma; somatic mutation).|G -> V (in lung carcinoma, pancreatic carcinoma, colon cancer and GASC; somatic mutation).		activation of MAPKK activity|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	plasma membrane	GTP binding|GTPase activity|protein binding	p.G12D(7175)|p.G12V(4780)|p.G12C(2482)|p.G12A(1180)|p.G12S(1119)|p.G12R(691)|p.G12?(50)|p.G12F(34)|p.G12G(6)|p.G12N(6)|p.G12L(5)|p.G12I(4)|p.G12_G13insG(4)|p.G12E(3)|p.G12W(3)|p.A11_G12insGA(2)|p.G12Y(2)|p.G12fs*3(1)		large_intestine(12391)|pancreas(3285)|lung(2847)|biliary_tract(521)|ovary(443)|endometrium(339)|haematopoietic_and_lymphoid_tissue(318)|stomach(203)|thyroid(149)|prostate(85)|soft_tissue(77)|small_intestine(62)|upper_aerodigestive_tract(59)|cervix(49)|urinary_tract(48)|skin(38)|liver(31)|breast(28)|testis(17)|oesophagus(15)|central_nervous_system(9)|peritoneum(6)|salivary_gland(6)|kidney(5)|gastrointestinal_tract_(site_indeterminate)(5)|thymus(5)|eye(4)|autonomic_ganglia(2)|bone(2)|genital_tract(1)|penis(1)|adrenal_gland(1)	21052	all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)		OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)			CCTACGCCACCAGCTCCAACT	0.348	Pancreas(8;6 143 191 305 2070 2426 4376 10944 11745 26467 38091 50869)	G12C(UMUC3_URINARY_TRACT)|G12R(CAL62_THYROID)|G12C(CALU1_LUNG)|G12C(NCIH2030_LUNG)|G12C(LU99_LUNG)|G12C(NCIH1792_LUNG)|G12R(KP2_PANCREAS)|G12C(KHM1B_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12C(NCIH2122_LUNG)|G12C(NCIH358_LUNG)|G12R(PSN1_PANCREAS)|G12C(KYSE410_OESOPHAGUS)|G12S(A549_LUNG)|G12R(HUPT3_PANCREAS)|G12R(TCCPAN2_PANCREAS)|G12C(HCC44_LUNG)|G12S(KMS20_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12C(SW1463_LARGE_INTESTINE)|G12C(NCIH23_LUNG)|G12C(LU65_LUNG)|G12C(NCIH1373_LUNG)|G12C(MIAPACA2_PANCREAS)|G12R(HS274T_BREAST)|G12S(LS123_LARGE_INTESTINE)|G12C(SW1573_LUNG)|G12C(SW837_LARGE_INTESTINE)|G12C(OV56_OVARY)|G12C(IALM_LUNG)	119	Mis		pancreatic|colorectal|lung|thyroid|AML|others				Cardiofaciocutaneous_syndrome|Noonan_syndrome	TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)			8	18					5.16669e-11	7.3031e-11	0.000978	1	0
Unknown	0	broad.mit.edu	37	12	31289572	31289572	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr12:31289572C>A	uc010sjy.1	-	16	2187	c.2187G>T	c.(2185-2187)TGG>TGT	p.W729C						RecName: Full=Ovostatin homolog 1; Flags: Precursor;												NA						TGACGAGGTCCCACATCCATG	0.363			NA											19	25					3.2961e-07	4.12567e-07	0.004878	1	0
BICD1	636	broad.mit.edu	37	12	32369271	32369271	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr12:32369271G>A	uc001rku.2	+	2	385	c.304G>A	c.(304-306)GAG>AAG	p.E102K	BICD1_uc001rkv.2_Missense_Mutation_p.E102K|BICD1_uc010skd.1_RNA	NM_001714	NP_001705	Q96G01	BICD1_HUMAN	bicaudal D homolog 1 isoform 1	102	Potential.				anatomical structure morphogenesis|intracellular mRNA localization|microtubule anchoring at microtubule organizing center|minus-end-directed organelle transport along microtubule|positive regulation of receptor-mediated endocytosis|protein localization to organelle|RNA processing|stress granule assembly|viral reproduction	cytoplasmic vesicle|cytoskeleton|cytosol|host cell viral assembly compartment|membrane|perinuclear region of cytoplasm|trans-Golgi network	cytoskeletal adaptor activity|dynactin binding|dynein binding|proteinase activated receptor binding|Rab GTPase binding|structural constituent of cytoskeleton			large_intestine(1)|central_nervous_system(1)	2	all_cancers(9;5.13e-11)|all_epithelial(9;2.71e-11)|all_lung(12;6.66e-10)|Acute lymphoblastic leukemia(23;0.0122)|Lung SC(12;0.0213)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.204)		OV - Ovarian serous cystadenocarcinoma(6;0.0201)			AGCATCGAAGGAGGCTTACTA	0.542			NA											27	30					0	0	0.00632	0	0
C12orf40	283461	broad.mit.edu	37	12	40076933	40076933	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr12:40076933G>A	uc001rmc.2	+	8	1374	c.1207G>A	c.(1207-1209)GAA>AAA	p.E403K	C12orf40_uc009zjv.1_RNA	NM_001031748	NP_001026918	Q86WS4	CL040_HUMAN	hypothetical protein LOC283461	403										ovary(6)	6						AAGCAGCTCTGAAAGAAAAGG	0.254			NA											14	22					0	0	0.006122	0	0
ADAMTS20	80070	broad.mit.edu	37	12	43771274	43771274	+	Missense_Mutation	SNP	C	C	A	rs112430320		TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr12:43771274C>A	uc010skx.1	-	32	4889	c.4889G>T	c.(4888-4890)CGG>CTG	p.R1630L		NM_025003	NP_079279	P59510	ATS20_HUMAN	a disintegrin-like and metalloprotease with	1630	TSP type-1 14.					proteinaceous extracellular matrix	zinc ion binding			central_nervous_system(5)|ovary(4)|lung(3)|large_intestine(2)|skin(2)|urinary_tract(1)|kidney(1)|pancreas(1)	19	all_cancers(12;2.6e-05)|Lung SC(27;0.184)	Lung NSC(34;0.0569)|all_lung(34;0.129)		GBM - Glioblastoma multiforme(48;0.0473)		AACTATAGGCCGAAGTCGATG	0.413			NA											5	11					0.000602214	0.00065942	0.000602	1	0
ADAMTS20	80070	broad.mit.edu	37	12	43925971	43925971	+	Nonsense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr12:43925971C>A	uc010skx.1	-	3	481	c.481G>T	c.(481-483)GAA>TAA	p.E161*		NM_025003	NP_079279	P59510	ATS20_HUMAN	a disintegrin-like and metalloprotease with	161						proteinaceous extracellular matrix	zinc ion binding			central_nervous_system(5)|ovary(4)|lung(3)|large_intestine(2)|skin(2)|urinary_tract(1)|kidney(1)|pancreas(1)	19	all_cancers(12;2.6e-05)|Lung SC(27;0.184)	Lung NSC(34;0.0569)|all_lung(34;0.129)		GBM - Glioblastoma multiforme(48;0.0473)		AAGAAATATTCACCGTTCTGT	0.343			NA											19	36					8.10497e-08	1.03987e-07	0.010504	1	0
ANO6	196527	broad.mit.edu	37	12	45751133	45751133	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr12:45751133G>C	uc001roo.2	+	8	1259	c.924G>C	c.(922-924)ATG>ATC	p.M308I	ANO6_uc010sld.1_Missense_Mutation_p.M308I|ANO6_uc010sle.1_Missense_Mutation_p.M308I|ANO6_uc010slf.1_Missense_Mutation_p.M329I|ANO6_uc010slg.1_Missense_Mutation_p.M290I	NM_001025356	NP_001020527	Q4KMQ2	ANO6_HUMAN	anoctamin 6 isoform a	308	Helical; (Potential).				activation of blood coagulation via clotting cascade|phosphatidylserine exposure on blood platelet	chloride channel complex|plasma membrane	chloride channel activity			ovary(1)|kidney(1)	2						ACACTCAGATGCTTCTCCTGG	0.393			NA											18	58					0	0	0.002299	0	0
COL2A1	1280	broad.mit.edu	37	12	48381440	48381440	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr12:48381440C>A	uc001rqu.2	-	19	1356	c.1175G>T	c.(1174-1176)CGC>CTC	p.R392L	COL2A1_uc009zkw.2_RNA|COL2A1_uc001rqv.2_Missense_Mutation_p.R323L	NM_001844	NP_001835	P02458	CO2A1_HUMAN	collagen, type II, alpha 1 isoform 1 precursor	392	Triple-helical region.				axon guidance|collagen fibril organization|embryonic skeletal joint morphogenesis|sensory perception of sound|visual perception	collagen type II	identical protein binding|platelet-derived growth factor binding			ovary(1)|skin(1)	2		Acute lymphoblastic leukemia(13;0.108)|all_hematologic(14;0.214)			Collagenase(DB00048)	AGGTTCACCGCGAGGACCTTG	0.617			NA											6	10					0.000442599	0.000487515	0.006214	1	0
CCNT1	904	broad.mit.edu	37	12	49088075	49088075	+	Missense_Mutation	SNP	T	T	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr12:49088075T>A	uc001rse.1	-	9	1245	c.922A>T	c.(922-924)AGT>TGT	p.S308C	LOC144438_uc001rsd.3_5'Flank|CCNT1_uc009zkz.1_Missense_Mutation_p.S23C	NM_001240	NP_001231	O60563	CCNT1_HUMAN	cyclin T1	308					cell cycle|cell division|interspecies interaction between organisms|positive regulation of viral transcription|protein phosphorylation|regulation of cyclin-dependent protein kinase activity|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|viral reproduction	nucleoplasm	DNA binding|protein kinase binding			ovary(3)|lung(1)|breast(1)|skin(1)	6						GGCACTGCACTTGTGGTAGAA	0.483			NA											14	50					0	0	0.003163	0	0
MLL2	8085	broad.mit.edu	37	12	49438017	49438017	+	Silent	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr12:49438017C>A	uc001rta.3	-	21	5154	c.5154G>T	c.(5152-5154)GCG>GCT	p.A1718A		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	1718					chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						TCAACACCTCCGCCTGTGCAG	0.617			NA	N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)	OREG0021780	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	10	16					0.000442599	0.000487515	0.006214	1	0
DNAJC22	79962	broad.mit.edu	37	12	49742871	49742871	+	Silent	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr12:49742871G>T	uc001rua.2	+	2	617	c.216G>T	c.(214-216)GTG>GTT	p.V72V	DNAJC22_uc001rub.2_Silent_p.V72V	NM_024902	NP_079178	Q8N4W6	DJC22_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 22	72					protein folding	integral to membrane	heat shock protein binding|unfolded protein binding			ovary(1)	1						CCAGAGGGGTGACACCCCCTC	0.577			NA											24	47					4.87955e-14	7.35147e-14	0.005443	1	0
KCNH3	23416	broad.mit.edu	37	12	49951519	49951519	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr12:49951519C>T	uc001ruh.1	+	15	3295	c.3035C>T	c.(3034-3036)CCC>CTC	p.P1012L	KCNH3_uc010smj.1_Missense_Mutation_p.P952L	NM_012284	NP_036416	Q9ULD8	KCNH3_HUMAN	potassium voltage-gated channel, subfamily H	1012	Pro-rich.|Cytoplasmic (Potential).				regulation of transcription, DNA-dependent	integral to membrane	two-component sensor activity|voltage-gated potassium channel activity				0						TGCTCTGAGCCCAGCACCCCT	0.672			NA											6	23					0	0	0.001168	0	0
TFCP2	7024	broad.mit.edu	37	12	51492610	51492610	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr12:51492610G>T	uc001rxw.2	-	13	1827	c.1368C>A	c.(1366-1368)AGC>AGA	p.S456R	TFCP2_uc001rxv.1_Missense_Mutation_p.S456R|TFCP2_uc009zlx.1_Missense_Mutation_p.S405R|TFCP2_uc001rxx.2_Missense_Mutation_p.S378R|TFCP2_uc009zly.1_Missense_Mutation_p.S358R	NM_005653	NP_005644	Q12800	TFCP2_HUMAN	transcription factor CP2	456					regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1						TGTAAATCTGGCTGATCTGGC	0.393			NA											7	32					8.12818e-05	9.21236e-05	0.001984	1	0
KRT5	3852	broad.mit.edu	37	12	52912779	52912779	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr12:52912779C>G	uc001san.2	-	2	884	c.721G>C	c.(721-723)GAC>CAC	p.D241H	KRT5_uc009zmh.2_Missense_Mutation_p.D241H	NM_000424	NP_000415	P13647	K2C5_HUMAN	keratin 5	241	Rod.|Coil 1B.				epidermis development|hemidesmosome assembly	cytosol|keratin filament	protein binding|structural constituent of cytoskeleton				0				BRCA - Breast invasive adenocarcinoma(357;0.189)		AGCTCTGAGTCCAGGCGGCCC	0.577			NA											22	124					0	0	0.00278	0	0
KRT79	338785	broad.mit.edu	37	12	53225306	53225306	+	Silent	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr12:53225306G>T	uc001sbb.2	-	2	615	c.582C>A	c.(580-582)CTC>CTA	p.L194L	KRT79_uc001sba.2_5'Flank	NM_175834	NP_787028	Q5XKE5	K2C79_HUMAN	keratin 6L	194	Rod.|Linker 1.					keratin filament	structural molecule activity			ovary(2)|skin(2)	4						AGGCCTCAAAGAGGGGCTCCA	0.607			NA											7	64					1.12685e-05	1.32356e-05	0.004482	1	0
ATF7	11016	broad.mit.edu	37	12	53911046	53911046	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr12:53911046G>A	uc001sdy.2	-	11	1381	c.1360C>T	c.(1360-1362)CGC>TGC	p.R454C	ATF7_uc010sok.1_RNA|ATF7_uc001sdz.2_Missense_Mutation_p.R443C|ATF7_uc010sol.1_Missense_Mutation_p.R422C|uc001sdx.2_RNA	NM_001130059	NP_001123531	P17544	ATF7_HUMAN	activating transcription factor 7 isoform 1	454	Essential for binding adenovirus 2 E1A.				interspecies interaction between organisms	cytoplasm|nuclear periphery|nucleoplasm	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|lung(1)	2						GCTGCAGAGCGAACACTGAGG	0.572			NA											10	49					0	0	0.008291	0	0
HOXC11	3227	broad.mit.edu	37	12	54369071	54369071	+	Silent	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr12:54369071G>T	uc001sem.2	+	2	905	c.789G>T	c.(787-789)CTG>CTT	p.L263L		NM_014212	NP_055027	O43248	HXC11_HUMAN	homeobox C11	263	Homeobox.				endoderm development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1						AGAAGCGGCTGCAGCTGTCCC	0.502			NA	T	NUP98	AML								6	58					1.26484e-09	1.72553e-09	0.00308	1	0
NCKAP1L	3071	broad.mit.edu	37	12	54894400	54894400	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr12:54894400G>T	uc001sgc.3	+	3	376	c.297G>T	c.(295-297)ATG>ATT	p.M99I	NCKAP1L_uc010sox.1_5'UTR|NCKAP1L_uc010soy.1_Missense_Mutation_p.M49I	NM_005337	NP_005328	P55160	NCKPL_HUMAN	NCK-associated protein 1-like	99					actin polymerization-dependent cell motility|B cell homeostasis|B cell receptor signaling pathway|cortical actin cytoskeleton organization|erythrocyte development|maintenance of cell polarity|myeloid cell homeostasis|negative regulation of apoptosis|negative regulation of interleukin-17 production|negative regulation of interleukin-6 production|negative regulation of myosin-light-chain-phosphatase activity|neutrophil chemotaxis|positive regulation of actin filament polymerization|positive regulation of B cell differentiation|positive regulation of B cell proliferation|positive regulation of CD4-positive, alpha-beta T cell differentiation|positive regulation of CD8-positive, alpha-beta T cell differentiation|positive regulation of cell adhesion mediated by integrin|positive regulation of erythrocyte differentiation|positive regulation of gamma-delta T cell differentiation|positive regulation of neutrophil chemotaxis|positive regulation of phagocytosis, engulfment|positive regulation of T cell proliferation|protein complex assembly|response to drug|T cell homeostasis	cytosol|integral to plasma membrane|membrane fraction|SCAR complex	protein complex binding|protein kinase activator activity|Rac GTPase activator activity			ovary(3)|central_nervous_system(1)	4						TGGATGTCATGGAATTTCGGG	0.398			NA											16	81					8.00594e-06	9.50106e-06	0.007413	1	0
PDE1B	5153	broad.mit.edu	37	12	54968998	54968998	+	Missense_Mutation	SNP	G	G	T	rs143206355		TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr12:54968998G>T	uc001sgd.1	+	11	1347	c.1181G>T	c.(1180-1182)CGT>CTT	p.R394L	PDE1B_uc010soz.1_Missense_Mutation_p.R257L|PDE1B_uc010spa.1_Missense_Mutation_p.R353L|PDE1B_uc001sgf.2_Missense_Mutation_p.R257L|PDE1B_uc001sge.2_Missense_Mutation_p.R374L|PDE1B_uc009znq.2_Missense_Mutation_p.R190L	NM_000924	NP_000915	Q01064	PDE1B_HUMAN	phosphodiesterase 1B isoform 1	394	Catalytic (By similarity).				activation of phospholipase C activity|apoptosis|nerve growth factor receptor signaling pathway|platelet activation	cytosol|nucleus	3',5'-cyclic-AMP phosphodiesterase activity|calmodulin binding|calmodulin-dependent cyclic-nucleotide phosphodiesterase activity|metal ion binding			upper_aerodigestive_tract(1)|ovary(1)	2						GAATTCTTCCGTCAGGTAGCG	0.572			NA											17	54					7.33628e-21	1.2285e-20	0.002299	1	0
METTL7B	196410	broad.mit.edu	37	12	56075848	56075848	+	Missense_Mutation	SNP	G	G	C	rs141569755		TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr12:56075848G>C	uc010spr.1	+	1	519	c.310G>C	c.(310-312)GAG>CAG	p.E104Q		NM_152637	NP_689850	Q6UX53	MET7B_HUMAN	methyltransferase like 7B precursor	104							methyltransferase activity				0						TCCCCACTTTGAGAAGTTCCT	0.572			NA											13	17					0	0	0.00245	0	0
ANKRD52	283373	broad.mit.edu	37	12	56642588	56642588	+	Silent	SNP	A	A	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr12:56642588A>T	uc001skm.3	-	16	1749	c.1659T>A	c.(1657-1659)GCT>GCA	p.A553A		NM_173595	NP_775866	Q8NB46	ANR52_HUMAN	ankyrin repeat domain 52	553	ANK 16.						protein binding			ovary(2)	2						CATAGTGCACAGCTGTGTAGC	0.632			NA											9	18					0	0	0.00245	0	0
STAT2	6773	broad.mit.edu	37	12	56737841	56737841	+	Silent	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr12:56737841C>A	uc001slc.2	-	23	2259	c.2181G>T	c.(2179-2181)CTG>CTT	p.L727L	STAT2_uc001slb.2_Silent_p.L269L|STAT2_uc001sld.2_Silent_p.L723L	NM_005419	NP_005410	P52630	STAT2_HUMAN	signal transducer and activator of transcription	727					interspecies interaction between organisms|JAK-STAT cascade|regulation of transcription from RNA polymerase II promoter|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	cytosol|nucleoplasm|plasma membrane	calcium ion binding|DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			ovary(1)|lung(1)|kidney(1)	3						gctctggcaccagccctagtt	0.184			NA											7	4					0.00198382	0.00213454	0.001984	1	0
TIMELESS	8914	broad.mit.edu	37	12	56815550	56815550	+	Nonsense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr12:56815550C>A	uc001slf.2	-	22	2854	c.2686G>T	c.(2686-2688)GAG>TAG	p.E896*		NM_003920	NP_003911	Q9UNS1	TIM_HUMAN	timeless homolog	896					cell division|circadian rhythm|detection of abiotic stimulus|mitosis|morphogenesis of an epithelium|negative regulation of transcription, DNA-dependent|regulation of S phase|response to DNA damage stimulus|transcription, DNA-dependent	nuclear chromatin				ovary(5)|breast(2)|pancreas(1)	8						CGCTGCAGCTCCAACTCCTGA	0.498			NA											21	109					2.65835e-16	4.20976e-16	0.007291	1	0
MYO1A	4640	broad.mit.edu	37	12	57435270	57435270	+	Silent	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr12:57435270C>A	uc001smw.3	-	13	1353	c.1110G>T	c.(1108-1110)GGG>GGT	p.G370G	MYO1A_uc010sqz.1_Silent_p.G208G|MYO1A_uc009zpd.2_Silent_p.G370G	NM_005379	NP_005370	Q9UBC5	MYO1A_HUMAN	myosin IA	370	Myosin head-like.				sensory perception of sound|vesicle localization	brush border|cortical actin cytoskeleton|filamentous actin|lateral plasma membrane|microvillus|myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			skin(4)|ovary(2)|urinary_tract(1)	7						TCTTCTTTTCCCCGATGCCCA	0.537			NA											9	57					1.58986e-06	1.94739e-06	0.008291	1	0
KIF5A	3798	broad.mit.edu	37	12	57971847	57971847	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr12:57971847C>A	uc001sor.1	+	22	2625	c.2417C>A	c.(2416-2418)ACG>AAG	p.T806K	KIF5A_uc010srr.1_Missense_Mutation_p.T717K	NM_004984	NP_004975	Q12840	KIF5A_HUMAN	kinesin family member 5A	806					blood coagulation|cell death|microtubule-based movement|synaptic transmission	cytosol|kinesin complex|membrane fraction|microtubule|perinuclear region of cytoplasm	ATP binding|microtubule motor activity			ovary(2)|skin(1)	3						CAAGACGTCACGACTCGAGTC	0.532			NA											21	52					4.26978e-12	6.21857e-12	0.00333	1	0
GEFT	115557	broad.mit.edu	37	12	58009028	58009028	+	Silent	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr12:58009028G>T	uc001spb.2	+	11	1429	c.969G>T	c.(967-969)GTG>GTT	p.V323V	GEFT_uc009zpy.2_Silent_p.V362V|GEFT_uc001soz.1_Intron|GEFT_uc001spa.2_Silent_p.V217V|uc001spc.2_RNA|GEFT_uc001spd.2_Silent_p.V28V	NM_182947	NP_891992	Q86VW2	ARHGP_HUMAN	RhoA/RAC/CDC42 exchange factor isoform 1	323	DH.				regulation of Rho protein signal transduction	cytosol|plasma membrane|sarcomere	Rho guanyl-nucleotide exchange factor activity				0	Melanoma(17;0.122)					AGCAAGCTGTGGAGGTCATGT	0.562			NA											11	38					1.58986e-06	1.94739e-06	0.008291	1	0
USP15	9958	broad.mit.edu	37	12	62715334	62715334	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr12:62715334G>C	uc001src.1	+	5	574	c.565G>C	c.(565-567)GAA>CAA	p.E189Q	USP15_uc001srb.1_Missense_Mutation_p.E189Q|USP15_uc001sra.2_Missense_Mutation_p.E189Q	NM_006313	NP_006304	Q9Y4E8	UBP15_HUMAN	ubiquitin specific peptidase 15	189					protein deubiquitination|ubiquitin-dependent protein catabolic process		cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(2)|lung(1)	3			GBM - Glioblastoma multiforme(1;0.000276)	GBM - Glioblastoma multiforme(28;0.0622)		TAACACATTTGAACCACTGAA	0.328	Melanoma(181;615 2041 39364 49691 50001)		NA											8	25					0	0	0.000978	0	0
HELB	92797	broad.mit.edu	37	12	66703861	66703861	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr12:66703861G>A	uc001sti.2	+	4	1181	c.1153G>A	c.(1153-1155)GTG>ATG	p.V385M	HELB_uc010ssz.1_RNA|HELB_uc009zqt.1_RNA	NM_033647	NP_387467	Q8NG08	HELB_HUMAN	helicase (DNA) B	385					DNA replication, synthesis of RNA primer		ATP binding|ATP-dependent 5'-3' DNA helicase activity|single-stranded DNA-dependent ATP-dependent DNA helicase activity			central_nervous_system(1)|pancreas(1)	2			GBM - Glioblastoma multiforme(2;0.000142)	GBM - Glioblastoma multiforme(28;0.0265)		TGTCGAAAAGGTGCTTGCCTC	0.418			NA											28	114					0	0	0.007291	0	0
GRIP1	23426	broad.mit.edu	37	12	66786519	66786519	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr12:66786519G>A	uc001stk.2	-	17	2292	c.2051C>T	c.(2050-2052)GCC>GTC	p.A684V	GRIP1_uc010sta.1_Missense_Mutation_p.A628V|GRIP1_uc001stj.2_Missense_Mutation_p.A466V|GRIP1_uc001stl.1_Missense_Mutation_p.A576V|GRIP1_uc001stm.2_Missense_Mutation_p.A684V	NM_021150	NP_066973	Q9Y3R0	GRIP1_HUMAN	glutamate receptor interacting protein 1	736	PDZ 6.				androgen receptor signaling pathway|intracellular signal transduction|positive regulation of transcription, DNA-dependent|synaptic transmission	cell junction|cytoplasmic membrane-bounded vesicle|cytosol|endoplasmic reticulum|postsynaptic membrane	androgen receptor binding|beta-catenin binding|protein C-terminus binding|receptor signaling complex scaffold activity|transcription coactivator activity			ovary(2)	2			GBM - Glioblastoma multiforme(2;0.00069)	GBM - Glioblastoma multiforme(28;0.0933)		CAAATGGATGGCTTCACTCAG	0.433			NA											13	73					0	0	0.001855	0	0
PTPRB	5787	broad.mit.edu	37	12	71003085	71003085	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr12:71003085G>T	uc001swb.3	-	2	119	c.89C>A	c.(88-90)ACC>AAC	p.T30N	PTPRB_uc010sto.1_Missense_Mutation_p.T30N|PTPRB_uc010stp.1_Missense_Mutation_p.T30N|PTPRB_uc001swc.3_Missense_Mutation_p.T248N|PTPRB_uc001swa.3_Missense_Mutation_p.T248N|PTPRB_uc001swd.3_Missense_Mutation_p.T247N|PTPRB_uc009zrr.1_Missense_Mutation_p.T127N|PTPRB_uc001swe.2_Missense_Mutation_p.T248N	NM_002837	NP_002828	P23467	PTPRB_HUMAN	protein tyrosine phosphatase, receptor type, B	30	Fibronectin type-III 1.|Extracellular (Potential).				angiogenesis	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			lung(2)|skin(1)	3	Renal(347;0.236)		GBM - Glioblastoma multiforme(2;2.17e-05)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00306)|STAD - Stomach adenocarcinoma(21;0.149)			CTCCGCCAGGGTGAAGTTACA	0.522			NA											12	34					0.00244969	0.00263201	0.00245	1	0
TMEM19	55266	broad.mit.edu	37	12	72094749	72094749	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr12:72094749G>T	uc001sws.2	+	6	1568	c.985G>T	c.(985-987)GCT>TCT	p.A329S	TMEM19_uc009zru.1_RNA	NM_018279	NP_060749	Q96HH6	TMM19_HUMAN	transmembrane protein 19	329	Helical; (Potential).					integral to membrane					0		Breast(359;0.0889)		GBM - Glioblastoma multiforme(134;0.044)		CCCAACTGCTGCTTGGGGTTT	0.428			NA											59	126					2.81305e-35	5.10123e-35	0.00361	1	0
NAP1L1	4673	broad.mit.edu	37	12	76444424	76444424	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr12:76444424C>A	uc001sxw.2	-	12	1358	c.946G>T	c.(946-948)GCT>TCT	p.A316S	NAP1L1_uc001sxv.2_Missense_Mutation_p.A274S|NAP1L1_uc001sxz.2_Missense_Mutation_p.A247S|NAP1L1_uc001sxx.2_Missense_Mutation_p.A316S|NAP1L1_uc001sxy.2_Missense_Mutation_p.A253S|NAP1L1_uc010sty.1_Missense_Mutation_p.A273S|NAP1L1_uc010stz.1_Missense_Mutation_p.A133S|NAP1L1_uc010sua.1_Missense_Mutation_p.A316S|NAP1L1_uc001syb.2_Missense_Mutation_p.A316S|NAP1L1_uc001sya.2_Missense_Mutation_p.A274S|NAP1L1_uc001syc.2_Missense_Mutation_p.A327S	NM_139207	NP_631946	P55209	NP1L1_HUMAN	nucleosome assembly protein 1-like 1	316					DNA replication|nucleosome assembly|positive regulation of cell proliferation	chromatin assembly complex|melanosome	protein binding			ovary(1)|skin(1)	2		Colorectal(145;0.09)				ATAGCTTCAGCATCATCATCC	0.323			NA											13	12					1.5842e-08	2.09024e-08	0.001855	1	0
NAV3	89795	broad.mit.edu	37	12	78400474	78400474	+	Nonsense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr12:78400474G>T	uc001syp.2	+	8	1329	c.1156G>T	c.(1156-1158)GAG>TAG	p.E386*	NAV3_uc001syo.2_Nonsense_Mutation_p.E386*	NM_014903	NP_055718	Q8IVL0	NAV3_HUMAN	neuron navigator 3	386						nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			large_intestine(6)|ovary(5)|lung(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	17						ATCCATGCTTGAGAAATTCAA	0.532			NA								HNSCC(70;0.22)			6	41					3.59834e-05	4.13823e-05	0.001168	1	0
NAV3	89795	broad.mit.edu	37	12	78401054	78401054	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr12:78401054G>T	uc001syp.2	+	8	1909	c.1736G>T	c.(1735-1737)TGT>TTT	p.C579F	NAV3_uc001syo.2_Missense_Mutation_p.C579F	NM_014903	NP_055718	Q8IVL0	NAV3_HUMAN	neuron navigator 3	579						nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			large_intestine(6)|ovary(5)|lung(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	17						GCTTCTAGTTGTCCTGCCCCT	0.507			NA								HNSCC(70;0.22)			11	34					0.000978159	0.00106403	0.000978	1	0
PPP1R12A	4659	broad.mit.edu	37	12	80214888	80214888	+	Missense_Mutation	SNP	T	T	C			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr12:80214888T>C	uc001syz.2	-	7	1193	c.926A>G	c.(925-927)GAC>GGC	p.D309G	PPP1R12A_uc010suc.1_Missense_Mutation_p.D222G|PPP1R12A_uc001sza.2_Missense_Mutation_p.D309G|PPP1R12A_uc010sud.1_Missense_Mutation_p.D309G|PPP1R12A_uc001szb.2_Missense_Mutation_p.D309G|PPP1R12A_uc001szc.2_Missense_Mutation_p.D309G	NM_002480	NP_002471	O14974	MYPT1_HUMAN	protein phosphatase 1, regulatory (inhibitor)	309						contractile fiber	protein binding|signal transducer activity			ovary(2)|breast(2)|large_intestine(1)|central_nervous_system(1)|skin(1)	7						CTGATTATTGTCCATATTTGC	0.318			NA											20	75					0	0	0.004656	0	0
MYF5	4617	broad.mit.edu	37	12	81111177	81111177	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr12:81111177C>A	uc001szg.2	+	1	470	c.335C>A	c.(334-336)ACC>AAC	p.T112N		NM_005593	NP_005584	P13349	MYF5_HUMAN	myogenic factor 5	112	Helix-loop-helix motif.				muscle cell fate commitment|positive regulation of muscle cell differentiation|skeletal muscle tissue development	nucleoplasm	DNA binding|protein heterodimerization activity|sequence-specific enhancer binding RNA polymerase II transcription factor activity			ovary(1)	1						TGTACCACGACCAACCCCAAC	0.592			NA											16	30					2.39187e-15	3.71838e-15	0.008871	1	0
ACSS3	79611	broad.mit.edu	37	12	81472085	81472085	+	Silent	SNP	C	C	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr12:81472085C>T	uc001szl.1	+	1	277	c.186C>T	c.(184-186)TAC>TAT	p.Y62Y	ACSS3_uc001szm.1_Silent_p.Y62Y	NM_024560	NP_078836	Q9H6R3	ACSS3_HUMAN	acyl-CoA synthetase short-chain family member 3	62						mitochondrion	acetate-CoA ligase activity|ATP binding			ovary(1)|lung(1)|central_nervous_system(1)|skin(1)	4						GCAGCGAGTACAAGACCCACT	0.682			NA											9	21					0	0	0.008291	0	0
FGD6	55785	broad.mit.edu	37	12	95535258	95535258	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr12:95535258C>A	uc001tdp.3	-	6	2967	c.2743G>T	c.(2743-2745)GAC>TAC	p.D915Y	FGD6_uc009zsx.2_Missense_Mutation_p.D48Y	NM_018351	NP_060821	Q6ZV73	FGD6_HUMAN	FYVE, RhoGEF and PH domain containing 6	915	DH.				actin cytoskeleton organization|filopodium assembly|regulation of Cdc42 GTPase activity|regulation of cell shape	cytoskeleton|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			ovary(2)|breast(1)	3						AGAATCCGGTCCTCAATCACT	0.448			NA											8	38					2.17888e-05	2.52532e-05	0.006214	1	0
NR1H4	9971	broad.mit.edu	37	12	100926248	100926248	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr12:100926248G>C	uc001tht.1	+	3	516	c.488G>C	c.(487-489)AGA>ACA	p.R163T	NR1H4_uc001thp.1_Missense_Mutation_p.R153T|NR1H4_uc001thq.1_Missense_Mutation_p.R153T|NR1H4_uc010svj.1_RNA|NR1H4_uc001thr.1_Missense_Mutation_p.R153T|NR1H4_uc010svk.1_Intron|NR1H4_uc001ths.1_Missense_Mutation_p.R163T	NM_005123	NP_005114	Q96RI1	NR1H4_HUMAN	nuclear receptor subfamily 1, group H, member 4	163	Nuclear receptor.				bile acid metabolic process|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|thyroid hormone receptor activity|transcription coactivator activity|transcription corepressor activity|zinc ion binding			ovary(1)|lung(1)|skin(1)	3						TTCTTCAGGAGAAGCATTACC	0.423			NA											6	37					0	0	0.00308	0	0
NR1H4	9971	broad.mit.edu	37	12	100926300	100926300	+	Silent	SNP	G	G	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr12:100926300G>A	uc001tht.1	+	3	568	c.540G>A	c.(538-540)GTG>GTA	p.V180V	NR1H4_uc001thp.1_Silent_p.V170V|NR1H4_uc001thq.1_Silent_p.V170V|NR1H4_uc010svj.1_RNA|NR1H4_uc001thr.1_Silent_p.V170V|NR1H4_uc010svk.1_Intron|NR1H4_uc001ths.1_Silent_p.V180V	NM_005123	NP_005114	Q96RI1	NR1H4_HUMAN	nuclear receptor subfamily 1, group H, member 4	180	NR C4-type.|Nuclear receptor.				bile acid metabolic process|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|thyroid hormone receptor activity|transcription coactivator activity|transcription corepressor activity|zinc ion binding			ovary(1)|lung(1)|skin(1)	3						GCAACTGTGTGATGGATATGT	0.413			NA											9	69					0	0	0.000978	0	0
OAS2	4939	broad.mit.edu	37	12	113448195	113448195	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr12:113448195G>T	uc001tuj.2	+	11	2206	c.2066G>T	c.(2065-2067)GGA>GTA	p.G689V	OAS2_uc001tui.1_3'UTR	NM_016817	NP_058197	P29728	OAS2_HUMAN	2'-5'-oligoadenylate synthetase 2 isoform 1	689					interferon-gamma-mediated signaling pathway|nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|type I interferon-mediated signaling pathway	endoplasmic reticulum|membrane|microsome|mitochondrion|nucleus	ATP binding|nucleotidyltransferase activity|RNA binding			ovary(1)	1						CAGACACCAGGAAGTTGTGGA	0.383	Pancreas(199;709 2232 18410 33584 35052)		NA											69	152					1.50986e-39	2.76498e-39	0.00361	1	0
TCTN2	79867	broad.mit.edu	37	12	124172603	124172603	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr12:124172603C>T	uc001ufp.2	+	7	898	c.770C>T	c.(769-771)CCC>CTC	p.P257L	TCTN2_uc009zya.2_Missense_Mutation_p.P256L	NM_024809	NP_079085	Q96GX1	TECT2_HUMAN	tectonic family member 2 isoform 1	257	Extracellular (Potential).				cilium assembly|smoothened signaling pathway	integral to membrane				ovary(1)	1	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000163)|Epithelial(86;0.000502)|all cancers(50;0.00451)		TTCAGTTCCCCCAAACAGGAC	0.313			NA											13	59					0	0	0.004007	0	0
DNAH10	196385	broad.mit.edu	37	12	124403315	124403315	+	Silent	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr12:124403315C>A	uc001uft.3	+	64	10996	c.10971C>A	c.(10969-10971)ATC>ATA	p.I3657I		NM_207437	NP_997320	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	3657					microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(3)|skin(2)|central_nervous_system(1)	6	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		GGGGGGCCATCCTGTTCTTCG	0.567			NA											10	19					0.000673444	0.000735791	0.008291	1	0
FZD10	11211	broad.mit.edu	37	12	130648479	130648479	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr12:130648479C>A	uc001uii.2	+	1	1448	c.992C>A	c.(991-993)ACG>AAG	p.T331K	uc001uig.1_5'Flank|uc001uih.1_5'Flank	NM_007197	NP_009128	Q9ULW2	FZD10_HUMAN	frizzled 10 precursor	331	Helical; Name=3; (Potential).				brain development|canonical Wnt receptor signaling pathway|cellular response to retinoic acid|embryo development|gonad development|negative regulation of Rho GTPase activity|neuron differentiation|non-canonical Wnt receptor signaling pathway|positive regulation of JUN kinase activity|positive regulation of Rac GTPase activity|regulation of actin cytoskeleton organization|vasculature development	cell projection|cell surface|cytoplasm|integral to plasma membrane	G-protein coupled receptor activity|PDZ domain binding|Wnt receptor activity|Wnt-protein binding			lung(3)|breast(1)|central_nervous_system(1)	5	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.3e-06)|Epithelial(86;1.66e-05)|all cancers(50;5.18e-05)		GTGGTCCTCACGCTCACCTGG	0.647			NA											8	31					0.000274275	0.000304364	0.004482	1	0
GPR133	283383	broad.mit.edu	37	12	131593298	131593298	+	Silent	SNP	A	A	G			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr12:131593298A>G	uc001uit.3	+	18	2476	c.1917A>G	c.(1915-1917)CTA>CTG	p.L639L	GPR133_uc010tbm.1_Silent_p.L671L|GPR133_uc009zyo.2_Intron|GPR133_uc001uiv.1_Silent_p.L158L|GPR133_uc009zyp.2_RNA	NM_198827	NP_942122	Q6QNK2	GP133_HUMAN	G protein-coupled receptor 133 precursor	639	Helical; Name=3; (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			pancreas(5)|ovary(3)|skin(2)	10	all_neural(191;0.0982)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.68e-06)|all cancers(50;2.71e-06)|Epithelial(86;6.75e-06)		CCGTGCTCCTACACTACTTCT	0.587			NA											65	152					0	0	0.00361	0	0
SFRS8	6433	broad.mit.edu	37	12	132262653	132262653	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr12:132262653C>T	uc001uja.1	+	14	2326	c.2186C>T	c.(2185-2187)CCT>CTT	p.P729L	SFRS8_uc010tbn.1_Missense_Mutation_p.P729L|SFRS8_uc001ujb.1_Missense_Mutation_p.P522L	NM_004592	NP_004583	Q12872	SFSWA_HUMAN	splicing factor, arginine/serine-rich 8	729					mRNA splice site selection|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding|RNA binding				0	all_neural(191;0.0982)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;3.44e-07)|Epithelial(86;2.94e-06)|all cancers(50;4.82e-05)		GGAGGCAGGCCTCTGCCTACT	0.433			NA											5	29					0	0	0.001168	0	0
POLE	5426	broad.mit.edu	37	12	133212492	133212492	+	Missense_Mutation	SNP	T	T	C			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr12:133212492T>C	uc001uks.1	-	42	5841	c.5797A>G	c.(5797-5799)ATT>GTT	p.I1933V	POLE_uc001ukq.1_Missense_Mutation_p.I143V|POLE_uc001ukr.1_Missense_Mutation_p.I737V|POLE_uc010tbq.1_RNA	NM_006231	NP_006222	Q07864	DPOE1_HUMAN	DNA-directed DNA polymerase epsilon	1933					base-excision repair, gap-filling|DNA synthesis involved in DNA repair|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	nucleoplasm	chromatin binding|DNA binding|DNA-directed DNA polymerase activity|nucleotide binding|protein binding|zinc ion binding			ovary(3)|skin(3)|lung(1)|central_nervous_system(1)	8	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0416)		OV - Ovarian serous cystadenocarcinoma(86;5.22e-08)|Epithelial(86;4.03e-07)|all cancers(50;1.18e-05)		CCACAGTGAATACGAGATGAA	0.517			NA						DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage					15	29					0	0	0.007413	0	0
POLE	5426	broad.mit.edu	37	12	133225973	133225973	+	Silent	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr12:133225973C>A	uc001uks.1	-	31	3968	c.3924G>T	c.(3922-3924)CGG>CGT	p.R1308R	POLE_uc001ukr.1_Silent_p.R112R|POLE_uc010tbq.1_RNA|POLE_uc009zyu.1_Silent_p.R1281R	NM_006231	NP_006222	Q07864	DPOE1_HUMAN	DNA-directed DNA polymerase epsilon	1308					base-excision repair, gap-filling|DNA synthesis involved in DNA repair|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	nucleoplasm	chromatin binding|DNA binding|DNA-directed DNA polymerase activity|nucleotide binding|protein binding|zinc ion binding			ovary(3)|skin(3)|lung(1)|central_nervous_system(1)	8	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0416)		OV - Ovarian serous cystadenocarcinoma(86;5.22e-08)|Epithelial(86;4.03e-07)|all cancers(50;1.18e-05)		CAGGACCATCCCGGATGGCCC	0.647			NA						DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage					11	26					3.86212e-05	4.42789e-05	0.008291	1	0
ANKLE2	23141	broad.mit.edu	37	12	133306433	133306433	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr12:133306433C>G	uc001ukx.2	-	11	2382	c.2315G>C	c.(2314-2316)AGA>ACA	p.R772T	ANKLE2_uc009zyw.1_Missense_Mutation_p.R127T	NM_015114	NP_055929	Q86XL3	ANKL2_HUMAN	ankyrin repeat and LEM domain containing 2	772						cytoplasm|integral to membrane|nuclear envelope					0	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0176)|Lung NSC(355;0.204)		OV - Ovarian serous cystadenocarcinoma(86;2.3e-08)|Epithelial(86;1.56e-07)|all cancers(50;4.94e-06)		TAACAAGTCTCTTTCTACTGC	0.443			NA											8	27					0	0	0.004482	0	0
SACS	26278	broad.mit.edu	37	13	23913627	23913627	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr13:23913627C>A	uc001uon.2	-	10	4977	c.4388G>T	c.(4387-4389)AGA>ATA	p.R1463I	SACS_uc001uoo.2_Missense_Mutation_p.R1316I|SACS_uc001uop.1_Intron|SACS_uc001uoq.1_Intron	NM_014363	NP_055178	Q9NZJ4	SACS_HUMAN	sacsin	1463					cell death|negative regulation of inclusion body assembly|protein folding	axon|cell body fiber|dendrite|mitochondrion|nucleus	ATP binding|chaperone binding|Hsp70 protein binding|proteasome binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		all_cancers(29;1.51e-22)|all_epithelial(30;7.82e-19)|all_lung(29;4.71e-18)|Lung SC(185;0.0225)|Breast(139;0.128)		all cancers(112;0.00197)|Epithelial(112;0.00854)|OV - Ovarian serous cystadenocarcinoma(117;0.0298)|Lung(94;0.189)		ATTTTTAATTCTTACAGTAAG	0.368			NA											17	51					2.4624e-09	3.32569e-09	0.008871	1	0
SACS	26278	broad.mit.edu	37	13	23914776	23914776	+	Nonsense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr13:23914776G>T	uc001uon.2	-	10	3828	c.3239C>A	c.(3238-3240)TCA>TAA	p.S1080*	SACS_uc001uoo.2_Nonsense_Mutation_p.S933*|SACS_uc001uop.1_Intron|SACS_uc001uoq.1_Intron	NM_014363	NP_055178	Q9NZJ4	SACS_HUMAN	sacsin	1080					cell death|negative regulation of inclusion body assembly|protein folding	axon|cell body fiber|dendrite|mitochondrion|nucleus	ATP binding|chaperone binding|Hsp70 protein binding|proteasome binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		all_cancers(29;1.51e-22)|all_epithelial(30;7.82e-19)|all_lung(29;4.71e-18)|Lung SC(185;0.0225)|Breast(139;0.128)		all cancers(112;0.00197)|Epithelial(112;0.00854)|OV - Ovarian serous cystadenocarcinoma(117;0.0298)|Lung(94;0.189)		AATATCTGGTGAGGTAAAAAC	0.378			NA											29	93					2.65835e-16	4.20976e-16	0.007291	1	0
RNF17	56163	broad.mit.edu	37	13	25406056	25406056	+	Nonsense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr13:25406056G>T	uc001upr.2	+	18	2463	c.2422G>T	c.(2422-2424)GAA>TAA	p.E808*	RNF17_uc010tdd.1_Nonsense_Mutation_p.E667*|RNF17_uc010aab.2_RNA|RNF17_uc010tde.1_Nonsense_Mutation_p.E808*|RNF17_uc001ups.2_Nonsense_Mutation_p.E747*|RNF17_uc010aac.2_Nonsense_Mutation_p.E6*	NM_031277	NP_112567	Q9BXT8	RNF17_HUMAN	ring finger protein 17	808					multicellular organismal development	cytoplasm|nucleus	hydrolase activity, acting on ester bonds|nucleic acid binding|zinc ion binding			ovary(1)|skin(1)	2		Lung SC(185;0.0225)|Breast(139;0.077)		all cancers(112;0.0114)|OV - Ovarian serous cystadenocarcinoma(117;0.0311)|Epithelial(112;0.0524)		GTGGTCCAAAGAAGCTAAAGA	0.289			NA											13	27					7.93312e-07	9.78967e-07	0.00245	1	0
RNF17	56163	broad.mit.edu	37	13	25419098	25419098	+	Splice_Site	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr13:25419098G>T	uc001upr.2	+	22	3024	c.2983_splice	c.e22-1	p.V995_splice	RNF17_uc010tdd.1_Splice_Site_p.V854_splice|RNF17_uc010aab.2_Splice_Site|RNF17_uc010tde.1_Splice_Site_p.V995_splice|RNF17_uc001ups.2_Splice_Site_p.V934_splice|RNF17_uc010aac.2_Splice_Site_p.V193_splice|RNF17_uc010aad.2_Splice_Site_p.V47_splice	NM_031277	NP_112567	Q9BXT8	RNF17_HUMAN	ring finger protein 17						multicellular organismal development	cytoplasm|nucleus	hydrolase activity, acting on ester bonds|nucleic acid binding|zinc ion binding			ovary(1)|skin(1)	2		Lung SC(185;0.0225)|Breast(139;0.077)		all cancers(112;0.0114)|OV - Ovarian serous cystadenocarcinoma(117;0.0311)|Epithelial(112;0.0524)		TATTTTCTTAGGTCTTGCTGT	0.318			NA											9	32					0.00136819	0.0014818	0.001368	1	0
CDK8	1024	broad.mit.edu	37	13	26957008	26957008	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr13:26957008G>A	uc001uqr.1	+	5	540	c.514G>A	c.(514-516)GCT>ACT	p.A172T	CDK8_uc001uqs.1_Missense_Mutation_p.A172T|CDK8_uc001uqt.1_Intron	NM_001260	NP_001251	P49336	CDK8_HUMAN	cyclin-dependent kinase 8	172	Protein kinase.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	mediator complex	ATP binding|cyclin-dependent protein kinase activity|protein binding|RNA polymerase II carboxy-terminal domain kinase activity			lung(2)|large_intestine(1)|ovary(1)|skin(1)	5	Colorectal(5;0.000442)	Lung SC(185;0.0156)|Breast(139;0.147)		all cancers(112;0.0384)|Epithelial(112;0.142)|OV - Ovarian serous cystadenocarcinoma(117;0.188)		AGTAAAAATTGGTATGTTATA	0.328			NA											15	36					0	0	0.007413	0	0
MTUS2	23281	broad.mit.edu	37	13	29608058	29608058	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr13:29608058C>A	uc001usl.3	+	2	2330	c.2272C>A	c.(2272-2274)CCT>ACT	p.P758T		NM_001033602	NP_001028774	Q5JR59	MTUS2_HUMAN	hypothetical protein LOC23281 isoform a	748	Mediates interaction with MAPRE1.					cytoplasm|microtubule	microtubule binding|protein homodimerization activity				0						GTTTTGTTCTCCTCCCTATGC	0.443			NA											4	12					0.00909568	0.00953828	0.009096	1	0
BRCA2	675	broad.mit.edu	37	13	32972857	32972857	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr13:32972857G>C	uc001uub.1	+	27	10434	c.10207G>C	c.(10207-10209)GAA>CAA	p.E3403Q		NM_000059	NP_000050	P51587	BRCA2_HUMAN	breast cancer 2, early onset	3403					cell cycle cytokinesis|centrosome duplication|double-strand break repair via homologous recombination|negative regulation of mammary gland epithelial cell proliferation|nucleotide-excision repair|positive regulation of transcription, DNA-dependent|regulation of S phase of mitotic cell cycle	BRCA2-MAGE-D1 complex|centrosome|nucleoplasm|stored secretory granule	gamma-tubulin binding|H3 histone acetyltransferase activity|H4 histone acetyltransferase activity|protease binding|single-stranded DNA binding			ovary(20)|endometrium(8)|lung(7)|breast(7)|oesophagus(5)|large_intestine(4)|central_nervous_system(3)|pancreas(3)|skin(2)|upper_aerodigestive_tract(1)|cervix(1)|salivary_gland(1)|liver(1)|kidney(1)	64		Lung SC(185;0.0262)		all cancers(112;7.13e-07)|Epithelial(112;1.59e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.000732)|BRCA - Breast invasive adenocarcinoma(63;0.0291)|GBM - Glioblastoma multiforme(144;0.0704)		CAGTACGGAAGAATGTGAGAA	0.388	Esophageal Squamous(138;838 1285 7957 30353 30468 36915 49332)		NA	D|Mis|N|F|S		breast|ovarian|pancreatic	breast|ovarian|pancreatic|leukemia  (FANCB|FANCD1)		Direct_reversal_of_damage|Homologous_recombination	FanconAnemia_type_D1_bi-allelic_BRCA2_mutations|Fanconi_Anemia|Pancreatic_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_BRCA2_type|Hereditary_Prostate_Cancer|Li-Fraumeni_syndrome	TCGA Ovarian(8;0.087)			12	33					0	0	0.001368	0	0
LHFP	10186	broad.mit.edu	37	13	40175066	40175066	+	Silent	SNP	G	G	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr13:40175066G>A	uc001uxf.2	-	2	799	c.288C>T	c.(286-288)CTC>CTT	p.L96L		NM_005780	NP_005771	Q9Y693	LHFP_HUMAN	lipoma HMGIC fusion partner precursor	96	Helical; (Potential).					integral to membrane	DNA binding		HMGA2/LHFP(2)	soft_tissue(2)|lung(1)|breast(1)	4		Lung NSC(96;3.55e-06)|Breast(139;0.00408)|Ovarian(182;0.0107)|Prostate(109;0.0118)|Lung SC(185;0.0719)|Hepatocellular(188;0.114)		OV - Ovarian serous cystadenocarcinoma(117;6.48e-46)|Epithelial(112;8.43e-42)|all cancers(112;1.42e-36)|GBM - Glioblastoma multiforme(144;0.00187)|BRCA - Breast invasive adenocarcinoma(63;0.00886)|KIRC - Kidney renal clear cell carcinoma(186;0.048)|Kidney(163;0.0601)|LUSC - Lung squamous cell carcinoma(192;0.105)		CCACCAGGAGGAGGAGGCCAC	0.592			NA	T	HMGA2	lipoma								26	75					0	0	0.008361	0	0
FOXO1	2308	broad.mit.edu	37	13	41134033	41134033	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr13:41134033G>T	uc001uxl.3	-	2	1980	c.1595C>A	c.(1594-1596)TCT>TAT	p.S532Y	FOXO1_uc010acc.1_Missense_Mutation_p.S347Y	NM_002015	NP_002006	Q12778	FOXO1_HUMAN	forkhead box O1	532					anti-apoptosis|blood vessel development|embryo development|endocrine pancreas development|insulin receptor signaling pathway|negative regulation of stress-activated MAPK cascade|nerve growth factor receptor signaling pathway|pattern specification process|phosphatidylinositol-mediated signaling|positive regulation of transcription from RNA polymerase II promoter|regulation of cell proliferation|regulation of sequence-specific DNA binding transcription factor activity|response to DNA damage stimulus|tissue development	cytosol|transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|protein kinase binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription factor binding		PAX3/FOXO1(749)|PAX7/FOXO1(197)	soft_tissue(946)|lung(1)|central_nervous_system(1)	948		Lung NSC(96;1.18e-05)|Breast(139;0.00394)|Prostate(109;0.0181)|Lung SC(185;0.0262)|Hepatocellular(188;0.194)		all cancers(112;7.32e-09)|Epithelial(112;2.87e-06)|OV - Ovarian serous cystadenocarcinoma(117;6.98e-05)|GBM - Glioblastoma multiforme(144;0.00394)|BRCA - Breast invasive adenocarcinoma(63;0.0815)		GTTAACTGCAGATGTCTGCTG	0.557			NA											35	89					2.05212e-20	3.41713e-20	0.005524	1	0
C13orf18	80183	broad.mit.edu	37	13	46946337	46946337	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr13:46946337G>A	uc010acl.2	-	3	879	c.274C>T	c.(274-276)CCT>TCT	p.P92S	C13orf18_uc001vbf.3_Missense_Mutation_p.P25S|C13orf18_uc001vbg.3_5'UTR|C13orf18_uc010tfz.1_Intron|C13orf18_uc010acm.2_5'UTR|C13orf18_uc010acn.2_Intron|C13orf18_uc001vbe.3_Missense_Mutation_p.P92S|C13orf18_uc001vbh.3_Missense_Mutation_p.P92S|C13orf18_uc001vbi.3_Intron|C13orf18_uc010aco.1_Missense_Mutation_p.P92S|C13orf18_uc010tga.1_Missense_Mutation_p.P25S	NM_025113	NP_079389	Q9H714	CM018_HUMAN	hypothetical protein LOC80183	92	Ser-rich.										0		Lung NSC(96;2.31e-05)|Breast(56;8.04e-05)|Prostate(109;0.00217)|Hepatocellular(98;0.0207)|Lung SC(185;0.0262)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;2.19e-05)		AGGCACGAAGGTGAAGGGCCT	0.582			NA											15	50					0	0	0.007413	0	0
FNDC3A	22862	broad.mit.edu	37	13	49712912	49712912	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr13:49712912G>T	uc001vcm.2	+	7	1095	c.790G>T	c.(790-792)GCA>TCA	p.A264S	FNDC3A_uc001vcl.1_Missense_Mutation_p.A264S|FNDC3A_uc001vcn.2_Missense_Mutation_p.A264S|FNDC3A_uc001vco.2_RNA|FNDC3A_uc001vcp.1_Missense_Mutation_p.A208S|FNDC3A_uc001vcq.2_Missense_Mutation_p.A208S	NM_001079673	NP_001073141	Q9Y2H6	FND3A_HUMAN	fibronectin type III domain containing 3A	264						Golgi membrane|integral to membrane				lung(2)	2		all_lung(13;7.44e-08)|Lung NSC(96;4.08e-06)|Breast(56;0.000111)|Prostate(109;0.00174)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|Lung SC(185;0.187)|all_neural(104;0.19)	KIRC - Kidney renal clear cell carcinoma(9;0.206)	GBM - Glioblastoma multiforme(99;2.94e-09)		AGCATTTGAAGCACTTCTTTC	0.239			NA											11	22					0.00244969	0.00263201	0.00245	1	0
PCDH17	27253	broad.mit.edu	37	13	58207404	58207404	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr13:58207404G>C	uc001vhq.1	+	1	1616	c.724G>C	c.(724-726)GTC>CTC	p.V242L	PCDH17_uc010aec.1_Missense_Mutation_p.V242L	NM_001040429	NP_001035519	O14917	PCD17_HUMAN	protocadherin 17 precursor	242	Extracellular (Potential).|Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			ovary(3)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	7		Lung NSC(96;0.027)|Prostate(109;0.0453)|Breast(118;0.128)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;1.06e-05)		CAACAGCCCGGTCTTCGAGGC	0.607	Melanoma(72;952 1291 1619 12849 33676)		NA											18	41					0	0	0.008871	0	0
PCDH17	27253	broad.mit.edu	37	13	58209020	58209020	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr13:58209020G>T	uc001vhq.1	+	1	3232	c.2340G>T	c.(2338-2340)ATG>ATT	p.M780I	PCDH17_uc010aec.1_Missense_Mutation_p.M780I	NM_001040429	NP_001035519	O14917	PCD17_HUMAN	protocadherin 17 precursor	780	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			ovary(3)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	7		Lung NSC(96;0.027)|Prostate(109;0.0453)|Breast(118;0.128)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;1.06e-05)		GGAACGCCATGAACGTCATGA	0.602	Melanoma(72;952 1291 1619 12849 33676)		NA											11	26					2.68362e-12	3.93545e-12	0.001368	1	0
DIAPH3	81624	broad.mit.edu	37	13	60240873	60240873	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr13:60240873G>A	uc001vht.2	-	28	3646	c.3427C>T	c.(3427-3429)CAT>TAT	p.H1143Y	DIAPH3_uc001vhs.2_RNA	NM_001042517	NP_001035982	Q9NSV4	DIAP3_HUMAN	diaphanous homolog 3 isoform a	1143					actin cytoskeleton organization		actin binding|Rho GTPase binding			ovary(2)	2		Breast(118;0.052)|Prostate(109;0.103)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;2.77e-05)		GTAGACGTATGAGTGTCTAGA	0.423			NA											28	59					0	0	0.002445	0	0
PCDH20	64881	broad.mit.edu	37	13	61985470	61985470	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr13:61985470C>T	uc001vid.3	-	2	3126	c.2762G>A	c.(2761-2763)AGG>AAG	p.R921K	PCDH20_uc010thj.1_Missense_Mutation_p.R921K	NM_022843	NP_073754	Q8N6Y1	PCD20_HUMAN	protocadherin 20	894	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|breast(1)|central_nervous_system(1)	6		Breast(118;0.195)|Prostate(109;0.229)		GBM - Glioblastoma multiforme(99;0.000118)		TTCATCTTCCCTGGGATGCTT	0.403			NA											5	35					0	0	0.001984	0	0
KLHL1	57626	broad.mit.edu	37	13	70535443	70535443	+	Missense_Mutation	SNP	T	T	C			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr13:70535443T>C	uc001vip.2	-	3	1608	c.814A>G	c.(814-816)ACA>GCA	p.T272A	KLHL1_uc010thm.1_Missense_Mutation_p.T211A	NM_020866	NP_065917	Q9NR64	KLHL1_HUMAN	kelch-like 1 protein	272	BTB.				actin cytoskeleton organization	cytoplasm|cytoskeleton	actin binding				0		Breast(118;0.000162)		COAD - Colon adenocarcinoma(199;0.000193)|GBM - Glioblastoma multiforme(99;0.000211)		GCCATACCTGTATATGCAAAT	0.353			NA											23	41					0	0	0.005443	0	0
MYCBP2	23077	broad.mit.edu	37	13	77817201	77817201	+	Missense_Mutation	SNP	T	T	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr13:77817201T>A	uc001vkf.2	-	18	2599	c.2508A>T	c.(2506-2508)GAA>GAT	p.E836D	MYCBP2_uc010aev.2_Missense_Mutation_p.E240D	NM_015057	NP_055872	O75592	MYCB2_HUMAN	MYC binding protein 2	836					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ligase activity|protein binding|zinc ion binding			ovary(4)|breast(4)|skin(3)|lung(2)|pancreas(1)	14		Breast(118;0.212)|Acute lymphoblastic leukemia(28;0.22)		GBM - Glioblastoma multiforme(99;0.109)		TACCTCTTCCTTCCTCTAATC	0.413			NA											16	56					0	0	0.010504	0	0
SLAIN1	122060	broad.mit.edu	37	13	78335215	78335215	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr13:78335215C>G	uc010thy.1	+	6	1218	c.1175C>G	c.(1174-1176)CCT>CGT	p.P392R	SLAIN1_uc001vkk.1_Missense_Mutation_p.P315R|SLAIN1_uc001vkl.1_Missense_Mutation_p.P271R|SLAIN1_uc010thz.1_Missense_Mutation_p.P270R|SLAIN1_uc010aex.1_Missense_Mutation_p.P157R|SLAIN1_uc010aey.1_Missense_Mutation_p.P157R|SLAIN1_uc001vkm.2_Missense_Mutation_p.P271R	NM_144595	NP_653196	Q8ND83	SLAI1_HUMAN	SLAIN motif family, member 1 B	534										ovary(1)|skin(1)	2		Acute lymphoblastic leukemia(28;0.0279)|Breast(118;0.037)		GBM - Glioblastoma multiforme(99;0.0853)		AGTAACCTGCCTCGAAGCAAA	0.468			NA											5	35					0	0	0.000602	0	0
SLITRK1	114798	broad.mit.edu	37	13	84454630	84454630	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr13:84454630C>G	uc001vlk.2	-	1	1899	c.1013G>C	c.(1012-1014)AGT>ACT	p.S338T		NM_052910	NP_443142	Q96PX8	SLIK1_HUMAN	slit and trk like 1 protein precursor	338	Extracellular (Potential).|LRRNT 2.					integral to membrane				ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	5	Medulloblastoma(90;0.18)	Breast(118;0.212)		GBM - Glioblastoma multiforme(99;0.07)		GCAGGGTAAACTGTTAGCTAA	0.537			NA											15	62					0	0	0.007413	0	0
GPC5	2262	broad.mit.edu	37	13	92345607	92345607	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr13:92345607C>A	uc010tif.1	+	3	858	c.492C>A	c.(490-492)AAC>AAA	p.N164K		NM_004466	NP_004457	P78333	GPC5_HUMAN	glypican 5 precursor	164						anchored to membrane|extracellular space|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding			ovary(2)|skin(2)|upper_aerodigestive_tract(1)	5	all_cancers(3;1.43e-07)|all_neural(89;0.0804)|Medulloblastoma(90;0.163)	Lung NSC(4;0.00454)				AATTTGTAAACAGATTTTTTG	0.463			NA											23	109					7.07758e-08	9.1199e-08	0.004656	1	0
DZIP1	22873	broad.mit.edu	37	13	96293773	96293773	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr13:96293773G>T	uc001vmk.2	-	5	1225	c.373C>A	c.(373-375)CAG>AAG	p.Q125K	DZIP1_uc001vml.2_Missense_Mutation_p.Q125K|DZIP1_uc001vmn.2_Missense_Mutation_p.Q114K	NM_198968	NP_945319	Q86YF9	DZIP1_HUMAN	DAZ interacting protein 1 isoform 2	125					germ cell development|multicellular organismal development|spermatogenesis	cytoplasm|nucleus	nucleic acid binding|protein binding|zinc ion binding			ovary(2)	2	all_neural(89;0.0878)|Breast(111;0.148)|Medulloblastoma(90;0.163)		BRCA - Breast invasive adenocarcinoma(86;0.141)			ATGGTGAACTGCGCCAGACGG	0.607			NA											15	66					1.99824e-07	2.51812e-07	0.00499	1	0
HS6ST3	266722	broad.mit.edu	37	13	97485369	97485369	+	Missense_Mutation	SNP	A	A	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr13:97485369A>T	uc001vmw.2	+	2	1357	c.1333A>T	c.(1333-1335)AGG>TGG	p.R445W		NM_153456	NP_703157	Q8IZP7	H6ST3_HUMAN	heparan sulfate 6-O-sulfotransferase 3	445	Lumenal (Potential).					integral to membrane	sulfotransferase activity			ovary(1)|skin(1)	2	all_neural(89;0.0878)|Medulloblastoma(90;0.163)					GCGAGAGCACAGGGACCACCA	0.617			NA											13	26					0	0	0.001368	0	0
FARP1	10160	broad.mit.edu	37	13	99092923	99092923	+	Splice_Site	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr13:99092923G>T	uc001vnj.2	+	24	2966	c.2630_splice	c.e24-1	p.K877_splice	FARP1_uc001vnh.2_Splice_Site_p.K908_splice	NM_005766	NP_005757	Q9Y4F1	FARP1_HUMAN	FERM, RhoGEF, and pleckstrin domain protein 1						regulation of Rho protein signal transduction	cytoplasm|cytoskeleton|extrinsic to membrane	cytoskeletal protein binding|Rho guanyl-nucleotide exchange factor activity			breast(2)	2	all_neural(89;0.0982)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)		BRCA - Breast invasive adenocarcinoma(86;0.233)			CCATCCTGTAGAGTCCCCTGA	0.632			NA											5	37					8.12818e-05	9.21236e-05	0.001984	1	0
ITGBL1	9358	broad.mit.edu	37	13	102235682	102235682	+	Silent	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr13:102235682C>A	uc001vpb.2	+	6	1063	c.844C>A	c.(844-846)CGA>AGA	p.R282R	ITGBL1_uc010agb.2_Silent_p.R233R|ITGBL1_uc001vpc.3_Silent_p.R141R	NM_004791	NP_004782	O95965	ITGBL_HUMAN	integrin, beta-like 1 (with EGF-like repeat	282	VI.|Cysteine-rich tandem repeats.				cell-matrix adhesion|integrin-mediated signaling pathway	extracellular region|integrin complex	binding|receptor activity			ovary(1)|skin(1)	2	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					TGTCTATGACCGATATTCTGA	0.363			NA											35	125					1.04594e-18	1.70913e-18	0.00623	1	0
ITGBL1	9358	broad.mit.edu	37	13	102366809	102366809	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr13:102366809G>T	uc001vpb.2	+	10	1520	c.1301G>T	c.(1300-1302)TGC>TTC	p.C434F	ITGBL1_uc010agb.2_Missense_Mutation_p.C385F|ITGBL1_uc001vpc.3_Missense_Mutation_p.C293F	NM_004791	NP_004782	O95965	ITGBL_HUMAN	integrin, beta-like 1 (with EGF-like repeat	434	IX.|Cysteine-rich tandem repeats.				cell-matrix adhesion|integrin-mediated signaling pathway	extracellular region|integrin complex	binding|receptor activity			ovary(1)|skin(1)	2	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					TGTGGGAAGTGCATTTGTTCT	0.408			NA											35	110					3.21399e-22	5.4682e-22	0.004878	1	0
COL4A1	1282	broad.mit.edu	37	13	110814614	110814614	+	Nonsense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr13:110814614G>T	uc001vqw.3	-	48	4547	c.4425C>A	c.(4423-4425)TAC>TAA	p.Y1475*	COL4A1_uc010agl.2_Intron	NM_001845	NP_001836	P02462	CO4A1_HUMAN	alpha 1 type IV collagen preproprotein	1475	Collagen IV NC1.				angiogenesis|axon guidance		extracellular matrix structural constituent|platelet-derived growth factor binding			ovary(3)|lung(1)|central_nervous_system(1)|pancreas(1)	6	all_cancers(4;9.8e-13)|all_epithelial(4;9.66e-08)|all_lung(23;3.75e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00178)|all_neural(89;0.00459)|Medulloblastoma(90;0.00596)|Lung SC(71;0.0604)	Breast(118;0.2)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.145)			TGCCTTGCACGTAGAGCAAAG	0.502			NA											69	208					2.65773e-34	4.79617e-34	0.00361	1	0
MCF2L	23263	broad.mit.edu	37	13	113741727	113741727	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr13:113741727G>T	uc001vsu.2	+	22	2745	c.2723G>T	c.(2722-2724)GGG>GTG	p.G908V	MCF2L_uc001vsq.2_Missense_Mutation_p.G908V|MCF2L_uc010tjr.1_Missense_Mutation_p.G851V|MCF2L_uc001vsr.2_Missense_Mutation_p.G855V|MCF2L_uc001vss.3_Missense_Mutation_p.G849V|MCF2L_uc010tjs.1_Missense_Mutation_p.G849V|MCF2L_uc001vst.1_Missense_Mutation_p.G813V	NM_001112732	NP_001106203	O15068	MCF2L_HUMAN	MCF.2 cell line derived transforming	881	PH.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|plasma membrane	Rho guanyl-nucleotide exchange factor activity			ovary(1)|kidney(1)	2	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)	all_cancers(25;0.118)|all_lung(25;0.0368)|all_epithelial(44;0.0396)|Lung NSC(25;0.129)|Breast(118;0.188)				AATGGGGAGGGGTATGAGAAA	0.592			NA											8	8					0.00307968	0.00328514	0.00308	1	0
OR4M1	441670	broad.mit.edu	37	14	20249337	20249337	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr14:20249337C>A	uc010tku.1	+	1	856	c.856C>A	c.(856-858)CCC>ACC	p.P286T		NM_001005500	NP_001005500	Q8NGD0	OR4M1_HUMAN	olfactory receptor, family 4, subfamily M,	286	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		TTTACTTAATCCCATTATTTA	0.368			NA											7	83					2.0095e-06	2.44928e-06	0.001984	1	0
OR4N2	390429	broad.mit.edu	37	14	20295891	20295891	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr14:20295891G>A	uc010tkv.1	+	1	284	c.284G>A	c.(283-285)AGA>AAA	p.R95K		NM_001004723	NP_001004723	Q8NGD1	OR4N2_HUMAN	olfactory receptor, family 4, subfamily N,	95	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|central_nervous_system(1)|skin(1)	4	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		ATCTCCTACAGAGGCTGCATC	0.527			NA											26	270					0	0	0.009535	0	0
OR4K15	81127	broad.mit.edu	37	14	20444345	20444345	+	Missense_Mutation	SNP	T	T	G			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr14:20444345T>G	uc010tkx.1	+	1	668	c.668T>G	c.(667-669)ATA>AGA	p.I223R		NM_001005486	NP_001005486	Q8NH41	OR4KF_HUMAN	olfactory receptor, family 4, subfamily K,	223	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;3.58e-06)	GBM - Glioblastoma multiforme(265;0.00327)		AGCTTACTAATAGTTGCAGAT	0.423			NA											35	101					0	0	0.00623	0	0
OR4N5	390437	broad.mit.edu	37	14	20612059	20612059	+	Silent	SNP	C	C	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr14:20612059C>T	uc010tla.1	+	1	165	c.165C>T	c.(163-165)CTC>CTT	p.L55L		NM_001004724	NP_001004724	Q8IXE1	OR4N5_HUMAN	olfactory receptor, family 4, subfamily N,	55	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	all_cancers(95;0.00108)		Epithelial(56;7.58e-07)|all cancers(55;3.84e-06)	GBM - Glioblastoma multiforme(265;0.0143)		ACCCTGGGCTCACAGCCCCCC	0.463			NA											54	180					0	0	0.00361	0	0
TEP1	7011	broad.mit.edu	37	14	20849739	20849739	+	Nonsense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr14:20849739C>A	uc001vxe.2	-	31	4571	c.4531G>T	c.(4531-4533)GAG>TAG	p.E1511*	TEP1_uc010ahk.2_Nonsense_Mutation_p.E854*|TEP1_uc010tlf.1_Intron|TEP1_uc010tlg.1_Nonsense_Mutation_p.E1403*|TEP1_uc010tlh.1_Intron	NM_007110	NP_009041	Q99973	TEP1_HUMAN	telomerase-associated protein 1	1511					telomere maintenance via recombination	chromosome, telomeric region|cytoplasm|nuclear matrix|soluble fraction|telomerase holoenzyme complex	ATP binding|RNA binding			ovary(5)	5	all_cancers(95;0.00123)	all_lung(585;0.235)	Epithelial(56;7.42e-08)|all cancers(55;6.46e-07)	GBM - Glioblastoma multiforme(265;0.028)|READ - Rectum adenocarcinoma(17;0.233)		GCCGTGTCCTCTAGCCCTGGC	0.647			NA											36	102					2.95478e-19	4.87112e-19	0.00874	1	0
TEP1	7011	broad.mit.edu	37	14	20872851	20872851	+	Silent	SNP	C	C	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr14:20872851C>T	uc001vxe.2	-	5	991	c.951G>A	c.(949-951)GCG>GCA	p.A317A	TEP1_uc010tlf.1_RNA|TEP1_uc010tlg.1_Intron	NM_007110	NP_009041	Q99973	TEP1_HUMAN	telomerase-associated protein 1	317	TROVE.				telomere maintenance via recombination	chromosome, telomeric region|cytoplasm|nuclear matrix|soluble fraction|telomerase holoenzyme complex	ATP binding|RNA binding			ovary(5)	5	all_cancers(95;0.00123)	all_lung(585;0.235)	Epithelial(56;7.42e-08)|all cancers(55;6.46e-07)	GBM - Glioblastoma multiforme(265;0.028)|READ - Rectum adenocarcinoma(17;0.233)		GGGGGCGACACGCCGGCAAGA	0.552			NA											25	47					0	0	0.00632	0	0
RNASE12	493901	broad.mit.edu	37	14	21058504	21058504	+	Nonsense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr14:21058504C>A	uc001vxt.2	-	1	479	c.379G>T	c.(379-381)GAG>TAG	p.E127*	RNASE11_uc010ahv.2_5'Flank|RNASE11_uc010ahx.2_5'Flank|RNASE11_uc010ahw.2_5'Flank|RNASE11_uc001vxs.2_5'Flank|uc001vxu.1_5'Flank	NM_001024822	NP_001019993	Q5GAN4	RNS12_HUMAN	ribonuclease, RNase A family, 12 (non-active)	127						extracellular region	nucleic acid binding|pancreatic ribonuclease activity			upper_aerodigestive_tract(1)|ovary(1)	2	all_cancers(95;0.00238)		Epithelial(56;1.85e-06)|all cancers(55;1.46e-05)	GBM - Glioblastoma multiforme(265;0.013)		ACAAACCCCTCTGTGGGGGAA	0.453			NA											21	49					4.54149e-19	7.47861e-19	0.002299	1	0
RPGRIP1	57096	broad.mit.edu	37	14	21779997	21779997	+	Silent	SNP	G	G	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr14:21779997G>A	uc001wag.2	+	8	945	c.945G>A	c.(943-945)CTG>CTA	p.L315L		NM_020366	NP_065099	Q96KN7	RPGR1_HUMAN	retinitis pigmentosa GTPase regulator	315	Potential.				response to stimulus|visual perception	cilium				ovary(4)|breast(2)|pancreas(1)	7	all_cancers(95;0.0017)	all_cancers(140;0.0973)	Epithelial(56;6.24e-07)|all cancers(55;6.56e-06)	GBM - Glioblastoma multiforme(265;0.00888)		AGGGAATCCTGAGTGCAGCCC	0.517			NA											4	11					0	0	0.001168	0	0
SUPT16H	11198	broad.mit.edu	37	14	21852072	21852072	+	Silent	SNP	C	C	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr14:21852072C>T	uc001wao.2	-	1	354	c.15G>A	c.(13-15)CTG>CTA	p.L5L	SUPT16H_uc001wap.2_Silent_p.L5L|SUPT16H_uc001waq.1_Silent_p.L5L	NM_007192	NP_009123	Q9Y5B9	SP16H_HUMAN	chromatin-specific transcription elongation	5					DNA repair|DNA replication|nucleosome disassembly|positive regulation of transcription elongation, DNA-dependent|positive regulation of viral transcription|transcription elongation from RNA polymerase II promoter|viral reproduction	chromosome|nucleoplasm	GTP binding				0	all_cancers(95;0.00115)		Epithelial(56;1.62e-06)|all cancers(55;1.49e-05)	GBM - Glioblastoma multiforme(265;0.0159)		CGTCTTTGTCCAGAGTCACAG	0.592			NA											20	44					0	0	0.00333	0	0
TOX4	9878	broad.mit.edu	37	14	21960676	21960676	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr14:21960676G>A	uc001waz.2	+	7	1004	c.901G>A	c.(901-903)GAA>AAA	p.E301K	TOX4_uc001way.2_Missense_Mutation_p.E171K|TOX4_uc001wba.2_RNA|TOX4_uc010tlu.1_Missense_Mutation_p.E278K|TOX4_uc010tlv.1_Missense_Mutation_p.E171K	NM_014828	NP_055643	O94842	TOX4_HUMAN	epidermal Langerhans cell protein LCP1	301						chromatin|nucleus|PTW/PP1 phosphatase complex	DNA binding|protein binding			ovary(1)	1	all_cancers(95;0.000465)		Epithelial(56;6.61e-06)|all cancers(55;5.15e-05)	GBM - Glioblastoma multiforme(265;0.0149)		GGCCACTGTGGAAACAGTGGA	0.413			NA											39	114					0	0	0.00361	0	0
ACIN1	22985	broad.mit.edu	37	14	23538785	23538785	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr14:23538785C>A	uc001wit.3	-	9	2667	c.2339G>T	c.(2338-2340)AGA>ATA	p.R780I	ACIN1_uc001wio.3_RNA|ACIN1_uc001wip.3_Missense_Mutation_p.R22I|ACIN1_uc001wiq.3_Missense_Mutation_p.R22I|ACIN1_uc001wir.3_Missense_Mutation_p.R53I|ACIN1_uc001wis.3_Missense_Mutation_p.R462I|ACIN1_uc010akg.2_Missense_Mutation_p.R780I	NM_014977	NP_055792	Q9UKV3	ACINU_HUMAN	apoptotic chromatin condensation inducer 1	780					apoptotic chromosome condensation|erythrocyte differentiation|positive regulation of monocyte differentiation	cytosol	ATPase activity|enzyme binding|nucleic acid binding|nucleotide binding			ovary(2)|large_intestine(1)|skin(1)	4	all_cancers(95;1.36e-05)			GBM - Glioblastoma multiforme(265;0.00816)		ATTTTCAGGTCTGTTTTCACT	0.537			NA									OREG0022596	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	13	31					3.27435e-08	4.26728e-08	0.00245	1	0
ACIN1	22985	broad.mit.edu	37	14	23547448	23547448	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr14:23547448C>T	uc001wit.3	-	8	2537	c.2209G>A	c.(2209-2211)GAG>AAG	p.E737K	ACIN1_uc001wis.3_Missense_Mutation_p.E419K|ACIN1_uc010akg.2_Missense_Mutation_p.E737K	NM_014977	NP_055792	Q9UKV3	ACINU_HUMAN	apoptotic chromatin condensation inducer 1	737					apoptotic chromosome condensation|erythrocyte differentiation|positive regulation of monocyte differentiation	cytosol	ATPase activity|enzyme binding|nucleic acid binding|nucleotide binding			ovary(2)|large_intestine(1)|skin(1)	4	all_cancers(95;1.36e-05)			GBM - Glioblastoma multiforme(265;0.00816)		GGCTCTGCCTCTTCAGCTTCA	0.473			NA											39	84					0	0	0.007835	0	0
ACIN1	22985	broad.mit.edu	37	14	23562726	23562726	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr14:23562726G>A	uc001wit.3	-	2	668	c.340C>T	c.(340-342)CAC>TAC	p.H114Y	ACIN1_uc010akg.2_Missense_Mutation_p.H114Y|ACIN1_uc010tnj.1_Missense_Mutation_p.H114Y|C14orf119_uc001wiu.2_5'Flank	NM_014977	NP_055792	Q9UKV3	ACINU_HUMAN	apoptotic chromatin condensation inducer 1	114					apoptotic chromosome condensation|erythrocyte differentiation|positive regulation of monocyte differentiation	cytosol	ATPase activity|enzyme binding|nucleic acid binding|nucleotide binding			ovary(2)|large_intestine(1)|skin(1)	4	all_cancers(95;1.36e-05)			GBM - Glioblastoma multiforme(265;0.00816)		GGTGTTGAGTGTTTCTGTAAA	0.433			NA											18	48					0	0	0.010504	0	0
MYH7	4625	broad.mit.edu	37	14	23894032	23894032	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr14:23894032C>G	uc001wjx.2	-	22	2731	c.2625G>C	c.(2623-2625)GAG>GAC	p.E875D		NM_000257	NP_000248	P12883	MYH7_HUMAN	myosin, heavy chain 7, cardiac muscle, beta	875	Potential.				adult heart development|muscle filament sliding|regulation of heart rate|ventricular cardiac muscle tissue morphogenesis	focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(3)|skin(1)	4	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00725)		ACACCATCTTCTCCTCCAGCT	0.587			NA											14	28					0	0	0.004007	0	0
LRRC16B	90668	broad.mit.edu	37	14	24535820	24535820	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr14:24535820C>G	uc001wlj.2	+	36	3794	c.3637C>G	c.(3637-3639)CCA>GCA	p.P1213A	LRRC16B_uc001wlk.2_Missense_Mutation_p.P266A	NM_138360	NP_612369	Q8ND23	LR16B_HUMAN	leucine rich repeat containing 16B	1213										ovary(2)|breast(2)|pancreas(1)	5				GBM - Glioblastoma multiforme(265;0.019)		AAGCACCAAACCAAGCTTCAG	0.547			NA											10	48					0	0	0.00245	0	0
RNF31	55072	broad.mit.edu	37	14	24619987	24619987	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr14:24619987G>T	uc001wmn.1	+	8	1627	c.1378G>T	c.(1378-1380)GGG>TGG	p.G460W	RNF31_uc001wml.1_Missense_Mutation_p.G309W|RNF31_uc001wmm.1_Intron|RNF31_uc010alg.1_Missense_Mutation_p.G275W|RNF31_uc001wmo.1_5'Flank|RNF31_uc001wmp.2_5'Flank	NM_017999	NP_060469	Q96EP0	RNF31_HUMAN	ring finger protein 31	460	Polyubiquitin-binding.				CD40 signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|protein linear polyubiquitination|T cell receptor signaling pathway	CD40 receptor complex|internal side of plasma membrane|LUBAC complex	ubiquitin binding|ubiquitin-protein ligase activity|zinc ion binding			large_intestine(1)|ovary(1)	2				GBM - Glioblastoma multiforme(265;0.00861)		CCCCAAGCCTGGGCCCCCACG	0.612			NA											19	58					3.99206e-14	6.05116e-14	0.007413	1	0
ADCY4	196883	broad.mit.edu	37	14	24798651	24798651	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr14:24798651G>C	uc001wov.2	-	9	1312	c.1306C>G	c.(1306-1308)CTT>GTT	p.L436V	ADCY4_uc001wow.2_Missense_Mutation_p.L436V|ADCY4_uc010toh.1_Missense_Mutation_p.L122V|ADCY4_uc001wox.2_Missense_Mutation_p.L436V|ADCY4_uc001woy.2_Missense_Mutation_p.L436V	NM_139247	NP_640340	Q8NFM4	ADCY4_HUMAN	adenylate cyclase 4	436	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	cytoplasm|integral to membrane|plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding|protein binding			ovary(1)|lung(1)|pancreas(1)	3				GBM - Glioblastoma multiforme(265;0.0192)		AGCTCCCGAAGGTAGGGGTCC	0.632			NA											14	33					0	0	0.007413	0	0
CTSG	1511	broad.mit.edu	37	14	25042962	25042962	+	Missense_Mutation	SNP	A	A	G			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr14:25042962A>G	uc001wpq.2	-	5	686	c.649T>C	c.(649-651)TAT>CAT	p.Y217H		NM_001911	NP_001902	P08311	CATG_HUMAN	cathepsin G preproprotein	217	Peptidase S1.				immune response|proteolysis	cell surface|extracellular space|plasma membrane|stored secretory granule	heparin binding|serine-type endopeptidase activity			ovary(2)	2				GBM - Glioblastoma multiforme(265;0.0269)		GACTTTCCATAGGAGACGATG	0.552			NA											30	83					0	0	0.002445	0	0
PRKD1	5587	broad.mit.edu	37	14	30105689	30105689	+	Missense_Mutation	SNP	G	G	A	rs146285949		TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr14:30105689G>A	uc001wqh.2	-	7	1178	c.997C>T	c.(997-999)CCT>TCT	p.P333S		NM_002742	NP_002733	Q15139	KPCD1_HUMAN	protein kinase D1	333					cell proliferation|intracellular signal transduction|sphingolipid metabolic process	cytosol|integral to plasma membrane	ATP binding|metal ion binding|protein binding|protein kinase C activity			lung(3)|large_intestine(2)|ovary(2)|skin(1)	8	Hepatocellular(127;0.0604)		LUAD - Lung adenocarcinoma(48;0.00527)|Lung(238;0.0252)	GBM - Glioblastoma multiforme(265;0.00888)		TCTGCCCCAGGGCTAAGCAAA	0.438			NA											19	41					0	0	0.010504	0	0
G2E3	55632	broad.mit.edu	37	14	31066645	31066645	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr14:31066645G>T	uc001wqk.2	+	7	702	c.548G>T	c.(547-549)GGA>GTA	p.G183V	G2E3_uc010tpe.1_Missense_Mutation_p.G137V|G2E3_uc010tpf.1_Missense_Mutation_p.G137V	NM_017769	NP_060239	Q7L622	G2E3_HUMAN	G2/M-phase specific E3 ubiquitin ligase	183	PHD-type 2; degenerate.				apoptosis|multicellular organismal development|protein modification process	Golgi apparatus|nucleolus	acid-amino acid ligase activity|protein binding|zinc ion binding			ovary(2)|skin(1)	3						ATAAATGCGGGAGTGTTTTTC	0.313			NA											34	109					2.6416e-12	3.88532e-12	0.00623	1	0
HEATR5A	25938	broad.mit.edu	37	14	31813206	31813206	+	Missense_Mutation	SNP	T	T	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr14:31813206T>A	uc001wrf.3	-	15	2322	c.2245A>T	c.(2245-2247)AAC>TAC	p.N749Y	HEATR5A_uc010ami.2_Missense_Mutation_p.N647Y|HEATR5A_uc001wrg.1_Missense_Mutation_p.N631Y|HEATR5A_uc010tpk.1_Missense_Mutation_p.N1042Y	NM_015473	NP_056288	Q86XA9	HTR5A_HUMAN	HEAT repeat containing 5A	1036							binding			ovary(1)	1	Hepatocellular(127;0.0877)|Breast(36;0.137)		LUAD - Lung adenocarcinoma(48;0.00292)|Lung(238;0.0164)|BRCA - Breast invasive adenocarcinoma(188;0.0797)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.0059)		CAGTCTGGGTTATCTTGCATT	0.428			NA											9	29					0	0	0.004482	0	0
PSMA6	5687	broad.mit.edu	37	14	35780014	35780014	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr14:35780014G>C	uc001wtd.2	+	4	431	c.322G>C	c.(322-324)GAG>CAG	p.E108Q	KIAA0391_uc001wta.2_RNA|PSMA6_uc010tpt.1_Missense_Mutation_p.E29Q|PSMA6_uc010tpu.1_Missense_Mutation_p.E29Q	NM_002791	NP_002782	P60900	PSA6_HUMAN	proteasome alpha 6 subunit	108					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of NF-kappaB transcription factor activity|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	mitochondrion|nuclear matrix|polysome|proteasome core complex, alpha-subunit complex|sarcomere	NF-kappaB binding|purine ribonucleoside triphosphate binding|RNA binding|threonine-type endopeptidase activity				0	Breast(36;0.0519)|Hepatocellular(127;0.158)		Lung(238;3.81e-05)|LUAD - Lung adenocarcinoma(48;5.59e-05)|Epithelial(34;0.00342)|all cancers(34;0.00973)	GBM - Glioblastoma multiforme(112;0.0234)		GTATGGCTATGAGATTCCTGT	0.423			NA											26	34					0	0	0.00632	0	0
CTAGE5	4253	broad.mit.edu	37	14	39762580	39762580	+	Nonsense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr14:39762580G>T	uc001wvg.3	+	6	826	c.490G>T	c.(490-492)GAA>TAA	p.E164*	CTAGE5_uc010tqe.1_Nonsense_Mutation_p.E126*|CTAGE5_uc001wuz.3_Nonsense_Mutation_p.E152*|CTAGE5_uc001wuy.3_Nonsense_Mutation_p.E84*|CTAGE5_uc001wvb.3_Nonsense_Mutation_p.E135*|CTAGE5_uc001wvc.3_Nonsense_Mutation_p.E109*|CTAGE5_uc001wva.3_Nonsense_Mutation_p.E135*|CTAGE5_uc001wve.1_Nonsense_Mutation_p.E140*|CTAGE5_uc001wvh.3_Nonsense_Mutation_p.E164*|CTAGE5_uc001wvf.3_Nonsense_Mutation_p.E89*|CTAGE5_uc001wvi.3_Nonsense_Mutation_p.E169*|CTAGE5_uc010amz.2_5'UTR|CTAGE5_uc001wvj.3_Nonsense_Mutation_p.E135*	NM_005930	NP_005921	O15320	CTGE5_HUMAN	CTAGE family, member 5 isoform 1	164	Potential.						enzyme activator activity|protein binding				0	Hepatocellular(127;0.213)		LUAD - Lung adenocarcinoma(48;0.000565)|Lung(238;0.000711)	GBM - Glioblastoma multiforme(112;0.0475)		TGAACAAGATGAATTGGTAAG	0.294			NA											10	20					6.40141e-05	7.28859e-05	0.000978	1	0
FBXO33	254170	broad.mit.edu	37	14	39900943	39900943	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr14:39900943C>T	uc001wvk.2	-	1	762	c.424G>A	c.(424-426)GAA>AAA	p.E142K		NM_203301	NP_976046	Q7Z6M2	FBX33_HUMAN	F-box protein 33	142											0	Hepatocellular(127;0.213)		LUAD - Lung adenocarcinoma(48;0.00107)|Lung(238;0.00121)|Epithelial(34;0.169)	GBM - Glioblastoma multiforme(112;0.0425)		GCGGCGAATTCAACACGCAGC	0.687			NA											19	29					0	0	0.00278	0	0
SDCCAG1	9147	broad.mit.edu	37	14	50301084	50301084	+	Missense_Mutation	SNP	T	T	C			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr14:50301084T>C	uc001wxc.2	-	7	726	c.658A>G	c.(658-660)AAA>GAA	p.K220E	SDCCAG1_uc010anj.1_Missense_Mutation_p.K220E|SDCCAG1_uc010tqi.1_Missense_Mutation_p.K220E|SDCCAG1_uc001wxe.2_Missense_Mutation_p.K178E|SDCCAG1_uc001wxd.1_5'Flank|SDCCAG1_uc010anq.1_Silent_p.L15L	NM_004713	NP_004704	O60524	NEMF_HUMAN	serologically defined colon cancer antigen 1	220						cytoplasm|nucleus					0	all_epithelial(31;0.000822)|Breast(41;0.0117)	all_lung(585;1.02e-05)		OV - Ovarian serous cystadenocarcinoma(311;5.99e-34)		GACATACCTTTAGTTTCAAGT	0.338			NA											15	33					0	0	0.003163	0	0
NID2	22795	broad.mit.edu	37	14	52495533	52495533	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr14:52495533C>A	uc001wzo.2	-	11	2671	c.2437G>T	c.(2437-2439)GGC>TGC	p.G813C	NID2_uc010tqs.1_Missense_Mutation_p.G813C|NID2_uc010tqt.1_Missense_Mutation_p.G813C|NID2_uc001wzp.2_Missense_Mutation_p.G813C	NM_007361	NP_031387	Q14112	NID2_HUMAN	nidogen 2 precursor	813	EGF-like 3; calcium-binding (Potential).					basement membrane	calcium ion binding|collagen binding			pancreas(2)|breast(2)|ovary(1)|liver(1)|skin(1)	7	Breast(41;0.0639)|all_epithelial(31;0.123)					GAGTTGGGGCCACAGCGATGA	0.448			NA											11	40					9.70103e-10	1.33322e-09	0.008291	1	0
PTGDR	5729	broad.mit.edu	37	14	52734663	52734663	+	Nonsense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr14:52734663C>A	uc001wzq.2	+	1	233	c.131C>A	c.(130-132)TCG>TAG	p.S44*		NM_000953	NP_000944	Q13258	PD2R_HUMAN	prostaglandin D2 receptor	44	Cytoplasmic (Potential).					integral to membrane|plasma membrane	prostaglandin D receptor activity|protein binding			ovary(1)|lung(1)|central_nervous_system(1)|skin(1)	4	Breast(41;0.0639)|all_epithelial(31;0.0887)				Nedocromil(DB00716)	CTGGCGCGCTCGGGGCTGGGG	0.687			NA											6	12					2.7689e-08	3.62443e-08	0.001984	1	0
TBPL2	387332	broad.mit.edu	37	14	55903622	55903622	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr14:55903622C>T	uc001xby.2	-	2	265	c.265G>A	c.(265-267)GAA>AAA	p.E89K		NM_199047	NP_950248	Q6SJ96	TBPL2_HUMAN	TATA box binding protein like 2	89					multicellular organismal development|transcription initiation from RNA polymerase II promoter	cytoplasm|nucleus	DNA binding				0						CCAGATGTTTCTTTGACTTCA	0.428			NA											16	56					0	0	0.006122	0	0
DACT1	51339	broad.mit.edu	37	14	59112634	59112634	+	Silent	SNP	G	G	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr14:59112634G>A	uc001xdw.2	+	4	1457	c.1293G>A	c.(1291-1293)AAG>AAA	p.K431K	DACT1_uc010trv.1_Silent_p.K150K|DACT1_uc001xdx.2_Silent_p.K394K|DACT1_uc010trw.1_Silent_p.K150K	NM_016651	NP_057735	Q9NYF0	DACT1_HUMAN	dapper 1 isoform 1	431					multicellular organismal development|Wnt receptor signaling pathway	cytoplasm|nucleus				large_intestine(2)|lung(2)|ovary(1)	5						CCGAAAGCAAGAGGGTGCCCC	0.592			NA											11	34					0	0	0.001368	0	0
DHRS7	51635	broad.mit.edu	37	14	60611705	60611705	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr14:60611705G>C	uc001xes.2	-	7	1183	c.999C>G	c.(997-999)ATC>ATG	p.I333M	C14orf135_uc001xeq.2_Intron|DHRS7_uc001xet.2_Missense_Mutation_p.I283M	NM_016029	NP_057113	Q9Y394	DHRS7_HUMAN	dehydrogenase/reductase (SDR family) member 7	333							binding|oxidoreductase activity			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(108;0.121)		TTGTCTTAAAGATTTTAAAAT	0.358			NA											5	62					0	0	0.000602	0	0
KCNH5	27133	broad.mit.edu	37	14	63174517	63174517	+	Silent	SNP	A	A	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr14:63174517A>T	uc001xfx.2	-	11	2727	c.2676T>A	c.(2674-2676)GCT>GCA	p.A892A	KCNH5_uc001xfy.2_3'UTR	NM_139318	NP_647479	Q8NCM2	KCNH5_HUMAN	potassium voltage-gated channel, subfamily H,	892	Cytoplasmic (Potential).				regulation of transcription, DNA-dependent	integral to membrane	calmodulin binding|two-component sensor activity|voltage-gated potassium channel activity			ovary(4)|skin(4)|central_nervous_system(1)	9				OV - Ovarian serous cystadenocarcinoma(108;0.00958)|BRCA - Breast invasive adenocarcinoma(234;0.168)		GCTTGGCATCAGCCTGGATGG	0.517			NA											24	69					0	0	0.00632	0	0
SYNE2	23224	broad.mit.edu	37	14	64520073	64520073	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr14:64520073G>C	uc001xgm.2	+	48	9672	c.9442G>C	c.(9442-9444)GAA>CAA	p.E3148Q	SYNE2_uc001xgl.2_Missense_Mutation_p.E3148Q|SYNE2_uc010apw.1_5'Flank	NM_015180	NP_055995	Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	3148	Cytoplasmic (Potential).				centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			ovary(8)|breast(4)|central_nervous_system(1)|pancreas(1)	14				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)		CTCACCAAAAGAATTGGATGA	0.299			NA											5	18					0	0	0.000602	0	0
SPTB	6710	broad.mit.edu	37	14	65252654	65252654	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr14:65252654G>A	uc001xht.2	-	16	3631	c.3577C>T	c.(3577-3579)CAC>TAC	p.H1193Y	SPTB_uc001xhr.2_Missense_Mutation_p.H1193Y|SPTB_uc001xhs.2_Missense_Mutation_p.H1193Y|SPTB_uc001xhu.2_Missense_Mutation_p.H1193Y	NM_000347	NP_000338	P11277	SPTB1_HUMAN	spectrin beta isoform b	1193	Spectrin 9.				actin filament capping|axon guidance	cell surface|cytosol|intrinsic to internal side of plasma membrane|protein complex|spectrin|spectrin-associated cytoskeleton	actin filament binding|structural constituent of cytoskeleton			ovary(7)|skin(2)|lung(1)|central_nervous_system(1)	11		all_lung(585;4.15e-09)		all cancers(60;4.33e-34)|OV - Ovarian serous cystadenocarcinoma(108;8.32e-20)|BRCA - Breast invasive adenocarcinoma(234;0.0628)		GGCTCCAAGTGAGCCAGAGTG	0.547			NA											31	65					0	0	0.002096	0	0
ZFYVE26	23503	broad.mit.edu	37	14	68234553	68234553	+	Silent	SNP	T	T	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr14:68234553T>A	uc001xka.2	-	31	5797	c.5658A>T	c.(5656-5658)CTA>CTT	p.L1886L	ZFYVE26_uc010tsz.1_RNA|ZFYVE26_uc001xkc.3_Silent_p.L1886L	NM_015346	NP_056161	Q68DK2	ZFY26_HUMAN	zinc finger, FYVE domain containing 26	1886					cell cycle|cell death|cytokinesis|double-strand break repair via homologous recombination	centrosome|midbody	metal ion binding|phosphatidylinositol-3-phosphate binding|protein binding			ovary(9)|breast(2)	11				all cancers(60;0.000763)|OV - Ovarian serous cystadenocarcinoma(108;0.0011)|BRCA - Breast invasive adenocarcinoma(234;0.0115)		TGGAGCTGTCTAGAGCTGAGA	0.483			NA											24	65					0	0	0.004656	0	0
ADAM21P1	145241	broad.mit.edu	37	14	70713356	70713356	+	Missense_Mutation	SNP	T	T	C			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr14:70713356T>C	uc010ttg.1	-	1	1163	c.512A>G	c.(511-513)CAT>CGT	p.H171R		NR_003951				SubName: Full=ADAM21-like protein;												0						ACCTAACTCATGGGCCACAGT	0.433			NA											24	223					0	0	0.009535	0	0
ADAM21	8747	broad.mit.edu	37	14	70925238	70925238	+	Missense_Mutation	SNP	A	A	G			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr14:70925238A>G	uc001xmd.2	+	1	1022	c.1022A>G	c.(1021-1023)CAT>CGT	p.H341R		NM_003813	NP_003804	Q9UKJ8	ADA21_HUMAN	ADAM metallopeptidase domain 21 preproprotein	341	Peptidase M12B.|Extracellular (Potential).	Zinc; catalytic (Potential).			proteolysis|single fertilization	integral to membrane	metalloendopeptidase activity|zinc ion binding			pancreas(1)|skin(1)	2				all cancers(60;0.00326)|BRCA - Breast invasive adenocarcinoma(234;0.00646)|OV - Ovarian serous cystadenocarcinoma(108;0.0401)		ACTGTGGCCCATGAGTTAGGT	0.428			NA											18	43					0	0	0.007413	0	0
PAPLN	89932	broad.mit.edu	37	14	73718736	73718736	+	Missense_Mutation	SNP	A	A	G			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr14:73718736A>G	uc010ttx.1	+	9	1017	c.854A>G	c.(853-855)CAG>CGG	p.Q285R	PAPLN_uc001xnw.3_Missense_Mutation_p.Q258R|PAPLN_uc010arl.2_RNA|PAPLN_uc010ttw.1_RNA|PAPLN_uc010tty.1_Missense_Mutation_p.Q285R	NM_173462	NP_775733	O95428	PPN_HUMAN	papilin	285						proteinaceous extracellular matrix	metalloendopeptidase activity|serine-type endopeptidase inhibitor activity|zinc ion binding			ovary(1)|central_nervous_system(1)|skin(1)	3				BRCA - Breast invasive adenocarcinoma(234;0.00394)|OV - Ovarian serous cystadenocarcinoma(108;0.0468)		CTCATCAGCCAGGAGCCCAAC	0.682			NA											11	28					0	0	0.007413	0	0
ACOT4	122970	broad.mit.edu	37	14	74061798	74061798	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr14:74061798G>C	uc001xoo.2	+	3	960	c.706G>C	c.(706-708)GAT>CAT	p.D236H		NM_152331	NP_689544	Q8N9L9	ACOT4_HUMAN	acyl-CoA thioesterase 4	236					acyl-CoA metabolic process|dicarboxylic acid metabolic process|long-chain fatty acid metabolic process|saturated monocarboxylic acid metabolic process|short-chain fatty acid metabolic process|succinyl-CoA metabolic process|unsaturated monocarboxylic acid metabolic process|very long-chain fatty acid metabolic process	peroxisome	carboxylesterase activity|palmitoyl-CoA hydrolase activity				0				BRCA - Breast invasive adenocarcinoma(234;0.00331)		TCTAGGAGCTGATATTTGTCT	0.423			NA											22	49					0	0	0.001882	0	0
ABCD4	5826	broad.mit.edu	37	14	74763132	74763132	+	Missense_Mutation	SNP	T	T	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr14:74763132T>A	uc001xpr.2	-	5	598	c.446A>T	c.(445-447)GAC>GTC	p.D149V	ABCD4_uc001xps.2_5'UTR|ABCD4_uc001xpt.2_5'UTR|ABCD4_uc010tur.1_Missense_Mutation_p.D62V|ABCD4_uc001xpu.2_5'UTR|ABCD4_uc001xpv.2_RNA	NM_005050	NP_005041	O14678	ABCD4_HUMAN	ATP-binding cassette, sub-family D, member 4	149	ABC transmembrane type-1.					ATP-binding cassette (ABC) transporter complex|integral to membrane|peroxisomal membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			upper_aerodigestive_tract(2)|large_intestine(1)|ovary(1)	4				BRCA - Breast invasive adenocarcinoma(234;0.00153)		TCGCTCCACGTCCTGGCTGAT	0.557			NA											20	51					0	0	0.001882	0	0
LTBP2	4053	broad.mit.edu	37	14	74995241	74995241	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr14:74995241C>A	uc001xqa.2	-	12	2700	c.2313G>T	c.(2311-2313)CAG>CAT	p.Q771H		NM_000428	NP_000419	Q14767	LTBP2_HUMAN	latent transforming growth factor beta binding	771					protein secretion|protein targeting|transforming growth factor beta receptor signaling pathway	extracellular space|proteinaceous extracellular matrix	calcium ion binding|growth factor binding			liver(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(234;0.00219)|READ - Rectum adenocarcinoma(1;0.0649)		CCCGGAGGGGCTGCCTCTCTG	0.652			NA											9	58					4.68919e-08	6.0898e-08	0.008291	1	0
YLPM1	56252	broad.mit.edu	37	14	75283738	75283738	+	Silent	SNP	C	C	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr14:75283738C>T	uc001xqj.3	+	14	5914	c.5790C>T	c.(5788-5790)ATC>ATT	p.I1930I	YLPM1_uc001xql.3_RNA|YLPM1_uc001xqm.1_Silent_p.I413I	NM_019589	NP_062535	P49750	YLPM1_HUMAN	YLP motif containing 1	1735					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear speck				ovary(2)|pancreas(1)	3			KIRC - Kidney renal clear cell carcinoma(43;0.238)	BRCA - Breast invasive adenocarcinoma(234;0.00162)		CCTTCATCATCCTGGATGCCA	0.403			NA											7	10					0	0	0.00308	0	0
FOS	2353	broad.mit.edu	37	14	75748078	75748078	+	Missense_Mutation	SNP	A	A	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr14:75748078A>T	uc001xrn.2	+	4	1299	c.1094A>T	c.(1093-1095)AAT>ATT	p.N365I	FOS_uc010tva.1_Missense_Mutation_p.N329I|FOS_uc010asi.2_Missense_Mutation_p.N251I|FOS_uc001xro.2_Missense_Mutation_p.N217I	NM_005252	NP_005243	P01100	FOS_HUMAN	v-fos FBJ murine osteosarcoma viral oncogene	365					cellular response to reactive oxygen species|DNA methylation|inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|regulation of sequence-specific DNA binding transcription factor activity|SMAD protein signal transduction|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|transcription from RNA polymerase II promoter|transforming growth factor beta receptor signaling pathway		protein dimerization activity|R-SMAD binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			lung(2)|ovary(1)	3		all_lung(585;0.0138)|all_epithelial(191;0.0263)|all_neural(303;0.112)		BRCA - Breast invasive adenocarcinoma(234;0.0117)		AGCAGCAGCAATGAGCCTTCC	0.657			NA											14	39					0	0	0.00245	0	0
TMEM63C	57156	broad.mit.edu	37	14	77710724	77710724	+	Silent	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr14:77710724G>T	uc001xtf.2	+	16	1586	c.1374G>T	c.(1372-1374)GTG>GTT	p.V458V	TMEM63C_uc010asq.1_Silent_p.V458V	NM_020431	NP_065164	Q9P1W3	TM63C_HUMAN	transmembrane protein 63C	458	Helical; (Potential).					integral to membrane					0			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0342)		TCCCCTCTGTGATGCTCTGGG	0.587			NA											61	123					1.15098e-32	2.06454e-32	0.00361	1	0
TSHR	7253	broad.mit.edu	37	14	81609993	81609993	+	Silent	SNP	C	C	A	rs139892516		TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr14:81609993C>A	uc001xvd.1	+	10	1747	c.1591C>A	c.(1591-1593)CGG>AGG	p.R531R		NM_000369	NP_000360	P16473	TSHR_HUMAN	thyroid stimulating hormone receptor isoform 1	531	Cytoplasmic (Potential).				cell-cell signaling|positive regulation of cell proliferation	integral to plasma membrane	protein binding|thyroid-stimulating hormone receptor activity			thyroid(289)|ovary(5)|lung(3)|kidney(1)|skin(1)	299				BRCA - Breast invasive adenocarcinoma(234;0.0402)	Thyrotropin Alfa(DB00024)	GCGCCTGGACCGGAAGATCCG	0.562			NA	Mis		toxic thyroid adenoma	thyroid  adenoma	Hereditary nonautoimmune hyperthyroidism; subclinical hypothyroidism 						7	20					1.26484e-09	1.72553e-09	0.00308	1	0
STON2	85439	broad.mit.edu	37	14	81743600	81743600	+	Silent	SNP	G	G	C			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr14:81743600G>C	uc010tvu.1	-	4	2256	c.2055C>G	c.(2053-2055)ACC>ACG	p.T685T	STON2_uc001xvk.1_Silent_p.T685T|STON2_uc010tvt.1_Silent_p.T482T	NM_033104	NP_149095	Q8WXE9	STON2_HUMAN	stonin 2	685	MHD.				endocytosis|intracellular protein transport|regulation of endocytosis	clathrin adaptor complex|nucleolus	protein binding			skin(3)|pancreas(2)	5				BRCA - Breast invasive adenocarcinoma(234;0.0348)		TGAAAGGCAAGGTCTTCTCAG	0.537			NA											32	98					0	0	0.004289	0	0
STON2	85439	broad.mit.edu	37	14	81864700	81864700	+	Silent	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr14:81864700G>T	uc010tvu.1	-	1	228	c.27C>A	c.(25-27)GCC>GCA	p.A9A	STON2_uc001xvk.1_Silent_p.A9A|STON2_uc010atc.1_Silent_p.A9A	NM_033104	NP_149095	Q8WXE9	STON2_HUMAN	stonin 2	9					endocytosis|intracellular protein transport|regulation of endocytosis	clathrin adaptor complex|nucleolus	protein binding			skin(3)|pancreas(2)	5				BRCA - Breast invasive adenocarcinoma(234;0.0348)		ACTGGTGGGTGGCAATCACAT	0.522			NA											11	26					5.16669e-11	7.3031e-11	0.000978	1	0
CALM1	801	broad.mit.edu	37	14	90870246	90870246	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr14:90870246G>T	uc001xyl.1	+	4	421	c.219G>T	c.(217-219)ATG>ATT	p.M73I	CALM1_uc010atq.1_Missense_Mutation_p.M74I|CALM1_uc010atr.1_Intron|CALM1_uc001xym.1_Missense_Mutation_p.M37I	NM_006888	NP_008819	P62158	CALM_HUMAN	calmodulin 1 isoform 1	73	EF-hand 2.				activation of phospholipase C activity|G-protein coupled receptor protein signaling pathway|glucose metabolic process|glycogen catabolic process|muscle contraction|negative regulation of ryanodine-sensitive calcium-release channel activity|nerve growth factor receptor signaling pathway|nitric oxide metabolic process|platelet activation|platelet degranulation|positive regulation of ryanodine-sensitive calcium-release channel activity|regulation of cytokinesis|regulation of nitric-oxide synthase activity|regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to calcium ion|synaptic transmission	centrosome|cytosol|extracellular region|nucleoplasm|plasma membrane|spindle microtubule|spindle pole	calcium ion binding|N-terminal myristoylation domain binding|phospholipase binding|protein domain specific binding|thioesterase binding|titin binding			central_nervous_system(1)	1		all_cancers(154;0.13)		COAD - Colon adenocarcinoma(157;0.208)	Aprindine(DB01429)|Bepridil(DB01244)|Dibucaine(DB00527)|Felodipine(DB01023)|Flunarizine(DB04841)|Fluphenazine(DB00623)|Isoflurane(DB00753)|Loperamide(DB00836)|Miconazole(DB01110)|Perphenazine(DB00850)|Phenoxybenzamine(DB00925)|Pimozide(DB01100)|Promethazine(DB01069)	TGACTATGATGGCTAGAAAAA	0.393			NA											6	25					0.00198382	0.00213454	0.001984	1	0
RPS6KA5	9252	broad.mit.edu	37	14	91526737	91526737	+	Silent	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr14:91526737G>T	uc001xys.2	-	1	257	c.42C>A	c.(40-42)ACC>ACA	p.T14T	RPS6KA5_uc010twi.1_5'Flank|RPS6KA5_uc001xyt.2_Silent_p.T14T|RPS6KA5_uc010att.1_RNA	NM_004755	NP_004746	O75582	KS6A5_HUMAN	ribosomal protein S6 kinase, polypeptide 5	14					axon guidance|epidermal growth factor receptor signaling pathway|histone phosphorylation|innate immune response|interleukin-1-mediated signaling pathway|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|positive regulation of histone acetylation|positive regulation of histone phosphorylation|positive regulation of transcription from RNA polymerase II promoter|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytoplasm|nucleoplasm	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			ovary(1)	1		all_cancers(154;0.0148)|Melanoma(154;0.099)|all_epithelial(191;0.146)		Epithelial(152;0.182)|BRCA - Breast invasive adenocarcinoma(234;0.201)		CGTCCGCGCTGGTCCCCGCGG	0.622			NA											3	9					6.4e-05	7.28859e-05	0.004672	1	0
KIAA1409	57578	broad.mit.edu	37	14	93962774	93962774	+	Silent	SNP	C	C	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr14:93962774C>T	uc001ybv.1	+	3	282	c.199C>T	c.(199-201)CTG>TTG	p.L67L	KIAA1409_uc001ybs.1_Silent_p.L67L|KIAA1409_uc001ybu.1_Intron	NM_020818	NP_065869	Q9P2D8	UNC79_HUMAN	hypothetical protein LOC57578	244						integral to membrane				ovary(10)|skin(4)|large_intestine(3)	17		all_cancers(154;0.0354)|all_epithelial(191;0.216)		Epithelial(152;0.188)		TTGTCAATTACTGGAATGCCT	0.274			NA											6	59					0	0	0.006214	0	0
HSP90AA1	3320	broad.mit.edu	37	14	102548771	102548771	+	Nonsense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr14:102548771G>T	uc001yku.3	-	10	1956	c.1766C>A	c.(1765-1767)TCA>TAA	p.S589*	HSP90AA1_uc001ykv.3_Nonsense_Mutation_p.S711*	NM_005348	NP_005339	P07900	HS90A_HUMAN	heat shock 90kDa protein 1, alpha isoform 2	589					axon guidance|cellular chaperone-mediated protein complex assembly|G2/M transition of mitotic cell cycle|nitric oxide metabolic process|positive regulation of nitric oxide biosynthetic process|protein import into mitochondrial outer membrane|protein refolding|regulation of nitric-oxide synthase activity|response to unfolded protein|signal transduction	cytosol|melanosome|plasma membrane	ATP binding|ATPase activity|nitric-oxide synthase regulator activity|protein homodimerization activity|TPR domain binding|unfolded protein binding			ovary(2)|central_nervous_system(2)|prostate(1)|lung(1)|breast(1)	7					Rifabutin(DB00615)	CAATCGGTTTGACACAACCAC	0.388			NA											8	7					0.00307968	0.00328514	0.00308	1	0
CYFIP1	23191	broad.mit.edu	37	15	22933576	22933576	+	Silent	SNP	A	A	G			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr15:22933576A>G	uc001yus.2	+	7	689	c.585A>G	c.(583-585)TTA>TTG	p.L195L	CYFIP1_uc001yut.2_Silent_p.L195L|CYFIP1_uc010aya.1_Silent_p.L223L	NM_014608	NP_055423	Q7L576	CYFP1_HUMAN	cytoplasmic FMR1 interacting protein 1 isoform	195					axon extension|lamellipodium assembly|regulation of cell shape|ruffle organization	cell junction|lamellipodium|mRNA cap binding complex|perinuclear region of cytoplasm|ruffle|synapse|synaptosome	actin filament binding|Rac GTPase binding			ovary(4)|pancreas(3)|liver(1)|skin(1)	9		all_cancers(20;2.26e-25)|all_epithelial(15;2.1e-22)|Lung NSC(15;3.36e-17)|all_lung(15;1.04e-16)|Breast(32;0.000776)|Colorectal(260;0.0488)		all cancers(64;2.22e-06)|Epithelial(43;1.49e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00101)		CTCAGTTTTTACGTAAAATGG	0.403			NA											8	17					0	0	0.000978	0	0
C15orf2	23742	broad.mit.edu	37	15	24921406	24921406	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr15:24921406G>T	uc001ywo.2	+	1	866	c.392G>T	c.(391-393)CGT>CTT	p.R131L		NM_018958	NP_061831	Q9NZP6	CO002_HUMAN	hypothetical protein LOC23742	131					cell differentiation|multicellular organismal development|spermatogenesis					ovary(2)|large_intestine(2)|skin(2)|kidney(1)|central_nervous_system(1)	8		all_cancers(20;2.14e-21)|all_epithelial(15;4.77e-19)|Lung NSC(15;1.43e-14)|all_lung(15;9.57e-14)|Breast(32;0.00086)		all cancers(64;3.19e-24)|Epithelial(43;2.67e-17)|GBM - Glioblastoma multiforme(186;7.36e-07)|BRCA - Breast invasive adenocarcinoma(123;0.000273)|Lung(196;0.229)		CCTTCACCACGTGAGCCGGCG	0.632			NA											4	56					0.00024832	0.000277424	0.009096	1	0
C15orf2	23742	broad.mit.edu	37	15	24923500	24923500	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr15:24923500C>T	uc001ywo.2	+	1	2960	c.2486C>T	c.(2485-2487)CCT>CTT	p.P829L		NM_018958	NP_061831	Q9NZP6	CO002_HUMAN	hypothetical protein LOC23742	829					cell differentiation|multicellular organismal development|spermatogenesis					ovary(2)|large_intestine(2)|skin(2)|kidney(1)|central_nervous_system(1)	8		all_cancers(20;2.14e-21)|all_epithelial(15;4.77e-19)|Lung NSC(15;1.43e-14)|all_lung(15;9.57e-14)|Breast(32;0.00086)		all cancers(64;3.19e-24)|Epithelial(43;2.67e-17)|GBM - Glioblastoma multiforme(186;7.36e-07)|BRCA - Breast invasive adenocarcinoma(123;0.000273)|Lung(196;0.229)		AATACCACCCCTCCTTCCAAA	0.498			NA											14	73					0	0	0.004007	0	0
GABRB3	2562	broad.mit.edu	37	15	26825485	26825485	+	Silent	SNP	C	C	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr15:26825485C>T	uc001zaz.2	-	6	805	c.663G>A	c.(661-663)AGG>AGA	p.R221R	GABRB3_uc010uae.1_Silent_p.R136R|GABRB3_uc001zba.2_Silent_p.R221R|GABRB3_uc001zbb.2_Silent_p.R277R	NM_000814	NP_000805	P28472	GBRB3_HUMAN	gamma-aminobutyric acid (GABA) A receptor, beta	221	Extracellular (Probable).				synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			upper_aerodigestive_tract(1)|ovary(1)|lung(1)|liver(1)|central_nervous_system(1)	5		all_cancers(20;1.89e-22)|all_lung(180;6.35e-15)|Breast(32;0.000279)|Colorectal(260;0.232)		all cancers(64;1.46e-07)|Epithelial(43;2.89e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0251)|COAD - Colon adenocarcinoma(236;0.235)|Lung(196;0.243)	Ethchlorvynol(DB00189)|Flurazepam(DB00690)|Lorazepam(DB00186)|Midazolam(DB00683)	AGACAACATTCCTCGAGACCA	0.552			NA											14	61					0	0	0.004007	0	0
GABRA5	2558	broad.mit.edu	37	15	27185199	27185199	+	Missense_Mutation	SNP	A	A	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr15:27185199A>T	uc001zbd.1	+	10	1191	c.852A>T	c.(850-852)GAA>GAT	p.E284D	GABRB3_uc001zbb.2_5'Flank	NM_000810	NP_000801	P31644	GBRA5_HUMAN	gamma-aminobutyric acid A receptor, alpha 5	284					gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity			ovary(1)	1		all_lung(180;4.59e-13)|Breast(32;0.000563)|Colorectal(260;0.227)		all cancers(64;1.45e-08)|Epithelial(43;4.96e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0232)|Lung(196;0.182)	Alprazolam(DB00404)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	TGAACCGGGAATCAGTCCCAG	0.512			NA											6	16					0	0	0.001984	0	0
GABRG3	2567	broad.mit.edu	37	15	27222262	27222262	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr15:27222262G>T	uc001zbg.1	+	2	333	c.167G>T	c.(166-168)AGA>ATA	p.R56I	GABRG3_uc001zbf.2_Missense_Mutation_p.R56I	NM_033223	NP_150092	Q99928	GBRG3_HUMAN	gamma-aminobutyric acid (GABA) A receptor, gamma	56	Extracellular (Probable).				gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity				0		all_lung(180;4.58e-12)|Breast(32;0.000625)|Colorectal(260;0.235)		all cancers(64;3.15e-07)|Epithelial(43;1.17e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0261)		AAGTTGCTAAGAGAATATGAT	0.348	NSCLC(114;800 1656 7410 37729 45293)		NA											12	76					1.5739e-10	2.19754e-10	0.004007	1	0
GABRG3	2567	broad.mit.edu	37	15	27772703	27772703	+	Silent	SNP	G	G	C			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr15:27772703G>C	uc001zbg.1	+	8	1156	c.990G>C	c.(988-990)GCG>GCC	p.A330A		NM_033223	NP_150092	Q99928	GBRG3_HUMAN	gamma-aminobutyric acid (GABA) A receptor, gamma	330	Helical; (Probable).				gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity				0		all_lung(180;4.58e-12)|Breast(32;0.000625)|Colorectal(260;0.235)		all cancers(64;3.15e-07)|Epithelial(43;1.17e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0261)		TCTTCGCCGCGCTGATGGAGT	0.552	NSCLC(114;800 1656 7410 37729 45293)		NA											4	7					0	0	0.000602	0	0
HERC2	8924	broad.mit.edu	37	15	28358796	28358796	+	Missense_Mutation	SNP	C	C	A	rs143209042		TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr15:28358796C>A	uc001zbj.2	-	91	14048	c.13942G>T	c.(13942-13944)GCT>TCT	p.A4648S	HERC2_uc001zbi.2_Missense_Mutation_p.A337S	NM_004667	NP_004658	O95714	HERC2_HUMAN	hect domain and RLD 2	4648	HECT.				DNA repair|intracellular protein transport|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	guanyl-nucleotide exchange factor activity|heme binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(4)|lung(4)|skin(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	13		all_lung(180;1.3e-11)|Breast(32;0.000194)|Colorectal(260;0.227)		all cancers(64;3.93e-09)|Epithelial(43;9.99e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0271)|GBM - Glioblastoma multiforme(186;0.0497)|Lung(196;0.199)		TCCCGAACAGCAGCCACCTGC	0.542			NA											12	21					2.32078e-09	3.14299e-09	0.003163	1	0
GOLGA8F	100132565	broad.mit.edu	37	15	28632777	28632777	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr15:28632777G>T	uc010uag.1	+	15	1433	c.1309G>T	c.(1309-1311)GGG>TGG	p.G437W	GOLGA8G_uc001zbp.3_Missense_Mutation_p.G231W|GOLGA8G_uc001zbo.2_Intron|GOLGA8G_uc001zbn.2_Missense_Mutation_p.G235W	NM_001164328	NP_001157800			golgi autoantigen, golgin subfamily a, 8F												0						GGACAGTGAGGGGGAGGAGGC	0.612			NA											8	44					2.39556e-15	3.71838e-15	0.00278	1	0
TRPM1	4308	broad.mit.edu	37	15	31294741	31294741	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr15:31294741C>T	uc001zfm.2	-	27	4224	c.4096G>A	c.(4096-4098)GAA>AAA	p.E1366K	TRPM1_uc010azy.2_Missense_Mutation_p.E1273K|TRPM1_uc001zfl.2_RNA	NM_002420	NP_002411	Q7Z4N2	TRPM1_HUMAN	transient receptor potential cation channel,	1366	Cytoplasmic (Potential).				cellular response to light stimulus|visual perception	integral to plasma membrane	calcium channel activity|receptor activity			ovary(2)|pancreas(1)|skin(1)	4		all_lung(180;1.92e-11)		all cancers(64;3.52e-16)|Epithelial(43;1.65e-11)|GBM - Glioblastoma multiforme(186;3.57e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00533)|COAD - Colon adenocarcinoma(236;0.0609)|Lung(196;0.199)		GTCTGTCTTTCATCATCTTCC	0.378			NA											20	51					0	0	0.010504	0	0
GREM1	26585	broad.mit.edu	37	15	33023329	33023329	+	Silent	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr15:33023329C>A	uc001zhe.1	+	2	597	c.438C>A	c.(436-438)CCC>CCA	p.P146P	GREM1_uc001zhd.1_Silent_p.P76P|GREM1_uc010uby.1_Silent_p.P105P	NM_013372	NP_037504	O60565	GREM1_HUMAN	gremlin-1 precursor	146	CTCK.				negative regulation of BMP signaling pathway|nervous system development|regulation of epithelial to mesenchymal transition	extracellular space	cytokine activity				0		all_lung(180;1.49e-09)		all cancers(64;2.97e-18)|Epithelial(43;3.15e-12)|GBM - Glioblastoma multiforme(186;2.32e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0107)		TCTGCAAGCCCAAGAAATTCA	0.502			NA											22	46					4.26978e-12	6.21857e-12	0.00333	1	0
RYR3	6263	broad.mit.edu	37	15	33951980	33951980	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr15:33951980G>T	uc001zhi.2	+	33	4438	c.4368G>T	c.(4366-4368)TTG>TTT	p.L1456F	RYR3_uc010bar.2_Missense_Mutation_p.L1456F	NM_001036	NP_001027	Q15413	RYR3_HUMAN	ryanodine receptor 3	1456	4 X approximate repeats.|B30.2/SPRY 3.|Cytoplasmic (By similarity).				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(5)|central_nervous_system(4)|lung(1)	10		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		GTACTTCTTTGTTTCAGTTTG	0.433			NA											7	27					1.12685e-05	1.32356e-05	0.004482	1	0
RYR3	6263	broad.mit.edu	37	15	34110877	34110877	+	Silent	SNP	G	G	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr15:34110877G>A	uc001zhi.2	+	76	10768	c.10698G>A	c.(10696-10698)ACG>ACA	p.T3566T	RYR3_uc010bar.2_Silent_p.T3561T	NM_001036	NP_001027	Q15413	RYR3_HUMAN	ryanodine receptor 3	3566					cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(5)|central_nervous_system(4)|lung(1)	10		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		ACGCTCTCACGGAGAGGAGGT	0.517			NA											9	14					0	0	0.000978	0	0
C15orf55	256646	broad.mit.edu	37	15	34646724	34646724	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr15:34646724C>A	uc001zif.2	+	5	1224	c.1069C>A	c.(1069-1071)CCT>ACT	p.P357T	C15orf55_uc010ucc.1_Missense_Mutation_p.P385T|C15orf55_uc010ucd.1_Missense_Mutation_p.P375T	NM_175741	NP_786883	Q86Y26	NUT_HUMAN	nuclear protein in testis	357						cytoplasm|nucleus			BRD4_ENST00000263377/C15orf55(24)|BRD3/C15orf55(3)	midline_organs(25)|ovary(2)|lung(2)|skin(1)	30		all_lung(180;2.78e-08)		all cancers(64;4.53e-18)|GBM - Glioblastoma multiforme(113;8.29e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0249)		ACCTCCTGCTCCTGAGGCACC	0.587			NA	T	BRD3|BRD4	lethal midline carcinoma								21	33					7.45023e-12	1.08294e-11	0.010504	1	0
THBS1	7057	broad.mit.edu	37	15	39882765	39882766	+	Missense_Mutation	DNP	GA	GA	TG			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	GA	GA	-	-	GA	GA	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr15:39882765_39882766GA>TG	uc001zkh.2	+	14	2373_2374	c.2194_2195GA>TG	c.(2194-2196)GAT>TGT	p.D732C	THBS1_uc010bbi.2_Missense_Mutation_p.D204C	NM_003246	NP_003237	P07996	TSP1_HUMAN	thrombospondin 1 precursor	732	TSP type-3 2.				activation of MAPK activity|anti-apoptosis|apoptosis|cell adhesion|cell cycle arrest|cell migration|cellular response to heat|chronic inflammatory response|engulfment of apoptotic cell|immune response|induction of apoptosis|negative regulation of angiogenesis|negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|negative regulation of blood vessel endothelial cell migration|negative regulation of caspase activity|negative regulation of cGMP-mediated signaling|negative regulation of dendritic cell antigen processing and presentation|negative regulation of endothelial cell proliferation|negative regulation of fibrinolysis|negative regulation of fibroblast growth factor receptor signaling pathway|negative regulation of focal adhesion assembly|negative regulation of interleukin-12 production|negative regulation of nitric oxide mediated signal transduction|negative regulation of plasma membrane long-chain fatty acid transport|negative regulation of plasminogen activation|peptide cross-linking|platelet activation|platelet degranulation|positive regulation of angiogenesis|positive regulation of blood vessel endothelial cell migration|positive regulation of fibroblast migration|positive regulation of macrophage activation|positive regulation of macrophage chemotaxis|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|positive regulation of reactive oxygen species metabolic process|positive regulation of transforming growth factor beta receptor signaling pathway|positive regulation of transforming growth factor-beta1 production|positive regulation of translation|positive regulation of tumor necrosis factor biosynthetic process|response to calcium ion|response to drug|response to glucose stimulus|response to hypoxia|response to magnesium ion|response to progesterone stimulus|sprouting angiogenesis	external side of plasma membrane|extracellular matrix|fibrinogen complex|platelet alpha granule lumen	calcium ion binding|collagen V binding|eukaryotic cell surface binding|fibrinogen binding|fibroblast growth factor 2 binding|fibronectin binding|heparin binding|identical protein binding|integrin binding|laminin binding|low-density lipoprotein particle binding|phosphatidylserine binding|proteoglycan binding|structural molecule activity|transforming growth factor beta binding			ovary(3)|central_nervous_system(3)	6		all_cancers(109;1.35e-17)|all_epithelial(112;2.07e-15)|Lung NSC(122;4.44e-11)|all_lung(180;1.11e-09)|Melanoma(134;0.0574)|Colorectal(260;0.117)|Ovarian(310;0.223)		GBM - Glioblastoma multiforme(113;2.77e-06)|BRCA - Breast invasive adenocarcinoma(123;0.105)	Becaplermin(DB00102)	CTATGACAAGGATGGAATTGGT	0.416			NA											19	40					0	0	0.004672	0	0
BAHD1	22893	broad.mit.edu	37	15	40750889	40750889	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr15:40750889C>T	uc001zlu.2	+	2	297	c.226C>T	c.(226-228)CGC>TGC	p.R76C	BAHD1_uc001zlt.2_Missense_Mutation_p.R76C|BAHD1_uc010bbp.1_Missense_Mutation_p.R76C|BAHD1_uc001zlv.2_Missense_Mutation_p.R76C	NM_014952	NP_055767	Q8TBE0	BAHD1_HUMAN	bromo adjacent homology domain containing 1	76					heterochromatin formation|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromatin silencing complex|chromosome	chromatin binding|DNA binding|protein binding				0		all_cancers(109;8.28e-19)|all_epithelial(112;2.64e-15)|Lung NSC(122;5.14e-11)|all_lung(180;1.27e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;3.46e-06)|BRCA - Breast invasive adenocarcinoma(123;0.08)		GCTGCTGACTCGCCTGGAGAA	0.637			NA											7	37					0	0	0.004482	0	0
INO80	54617	broad.mit.edu	37	15	41387985	41387985	+	Silent	SNP	T	T	C			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr15:41387985T>C	uc001zni.2	-	3	498	c.285A>G	c.(283-285)ACA>ACG	p.T95T	INO80_uc010ucu.1_RNA	NM_017553	NP_060023	Q9ULG1	INO80_HUMAN	INO80 complex homolog 1	95	Assembles INO80 complex module with putative regulatory components INO80E, INO80F, UCHL5, NFRKB, MCRS1 and IN80D.				cell division|cellular response to ionizing radiation|cellular response to UV|chromatin remodeling|double-strand break repair via homologous recombination|mitotic sister chromatid segregation|positive regulation of cell growth|positive regulation of DNA replication involved in S phase|positive regulation of transcription from RNA polymerase II promoter|regulation of G1/S transition of mitotic cell cycle|spindle assembly|UV-damage excision repair	Ino80 complex|microtubule	actin binding|alpha-tubulin binding|ATP binding|ATPase activity|DNA binding|DNA helicase activity			ovary(2)|pancreas(1)|skin(1)	4						TCAGAGAATATGTGTTTAACA	0.428			NA											9	44					0	0	0.000978	0	0
MGA	23269	broad.mit.edu	37	15	42000361	42000361	+	Nonsense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr15:42000361G>T	uc001zog.1	+	7	2471	c.2380G>T	c.(2380-2382)GGA>TGA	p.G794*	MGA_uc010ucy.1_Nonsense_Mutation_p.G794*|MGA_uc010ucz.1_Nonsense_Mutation_p.G794*	NM_001080541	NP_001074010	Q8IWI9	MGAP_HUMAN	MAX-interacting protein isoform 2	794						MLL1 complex	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(6)|kidney(3)|upper_aerodigestive_tract(1)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	12		all_cancers(109;0.00356)|all_epithelial(112;0.0413)|all_lung(180;0.18)|Ovarian(310;0.238)		OV - Ovarian serous cystadenocarcinoma(18;1.41e-18)|GBM - Glioblastoma multiforme(113;2.15e-06)|COAD - Colon adenocarcinoma(120;0.031)|Lung(196;0.0721)|BRCA - Breast invasive adenocarcinoma(123;0.0964)|Colorectal(105;0.0998)|LUSC - Lung squamous cell carcinoma(244;0.235)		TAAGATCAAGGGATGGAGGGG	0.343			NA											3	5					0.004672	0.00493414	0.004672	1	0
PLA2G4F	255189	broad.mit.edu	37	15	42436757	42436757	+	Silent	SNP	C	C	G			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr15:42436757C>G	uc001zoz.2	-	17	1929	c.1866G>C	c.(1864-1866)GTG>GTC	p.V622V	PLA2G4F_uc010bcq.2_5'UTR|PLA2G4F_uc001zoy.2_Silent_p.V254V|PLA2G4F_uc010bcr.2_Silent_p.V373V|PLA2G4F_uc001zpa.2_Silent_p.V373V|PLA2G4F_uc010bcs.2_Silent_p.V409V	NM_213600	NP_998765	Q68DD2	PA24F_HUMAN	phospholipase A2, group IVF	622	PLA2c.				phospholipid catabolic process	cytosol|lysosomal membrane	metal ion binding|phospholipase A2 activity			ovary(4)	4		all_cancers(109;4.82e-12)|all_epithelial(112;5.64e-11)|Lung NSC(122;2.17e-07)|all_lung(180;8.79e-07)|Melanoma(134;0.091)		GBM - Glioblastoma multiforme(94;8.97e-07)		ATATGTCCAGCACAGCCTGGG	0.622			NA											6	39					0	0	0.00308	0	0
FBN1	2200	broad.mit.edu	37	15	48718036	48718036	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr15:48718036G>T	uc001zwx.1	-	59	7558	c.7230C>A	c.(7228-7230)CAC>CAA	p.H2410Q	FBN1_uc010beo.1_RNA	NM_000138	NP_000129	P35555	FBN1_HUMAN	fibrillin 1 precursor	2410	EGF-like 41; calcium-binding.				heart development|negative regulation of BMP signaling pathway by extracellular sequestering of BMP|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|skeletal system development	basement membrane|extracellular space|microfibril	calcium ion binding|extracellular matrix structural constituent|protein binding			ovary(2)|large_intestine(1)	3		all_lung(180;0.00279)		all cancers(107;4.24e-07)|GBM - Glioblastoma multiforme(94;1.41e-05)		GGCAAACATCGTGAATAACCT	0.343			NA											9	65					7.48243e-07	9.25655e-07	0.006214	1	0
SECISBP2L	9728	broad.mit.edu	37	15	49284862	49284862	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr15:49284862C>A	uc001zxe.1	-	18	3019	c.2885G>T	c.(2884-2886)GGC>GTC	p.G962V	SECISBP2L_uc001zxd.1_Missense_Mutation_p.G917V	NM_014701	NP_055516	Q93073	SBP2L_HUMAN	SECIS binding protein 2-like	962										breast(1)|skin(1)	2						ATCCAAAGAGCCAGTCTCTGT	0.453			NA											9	57					1.58986e-06	1.94739e-06	0.008291	1	0
GALK2	2585	broad.mit.edu	37	15	49531417	49531417	+	Splice_Site	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr15:49531417G>T	uc001zxj.1	+	5	456	c.358_splice	c.e5-1	p.E120_splice	GALK2_uc001zxi.1_Splice_Site_p.E109_splice|GALK2_uc010ufb.1_Splice_Site_p.E96_splice|GALK2_uc001zxk.2_Splice_Site|GALK2_uc010ufc.1_Splice_Site_p.E96_splice	NM_002044	NP_002035	Q01415	GALK2_HUMAN	galactokinase 2 isoform 1						galactose metabolic process	cytoplasm	ATP binding|galactokinase activity|N-acetylgalactosamine kinase activity			breast(1)	1		all_lung(180;0.000325)		all cancers(107;3.71e-08)|GBM - Glioblastoma multiforme(94;7e-05)		TATATTCTTAGGAACACTTTG	0.408			NA											12	26					1.05317e-09	1.44471e-09	0.00245	1	0
DMXL2	23312	broad.mit.edu	37	15	51855592	51855592	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr15:51855592C>A	uc002abf.2	-	6	778	c.553G>T	c.(553-555)GCT>TCT	p.A185S	DMXL2_uc010ufy.1_Missense_Mutation_p.A185S|DMXL2_uc010bfa.2_Missense_Mutation_p.A185S	NM_015263	NP_056078	Q8TDJ6	DMXL2_HUMAN	Dmx-like 2	185	WD 2.					cell junction|synaptic vesicle membrane	Rab GTPase binding			ovary(6)|skin(3)	9				all cancers(107;0.00494)		CCAGCAGTAGCAAAATATTCA	0.284			NA											6	19					8.12818e-05	9.21236e-05	0.001984	1	0
WDR72	256764	broad.mit.edu	37	15	53908067	53908067	+	Missense_Mutation	SNP	T	T	G			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr15:53908067T>G	uc002acj.2	-	15	2378	c.2336A>C	c.(2335-2337)CAG>CCG	p.Q779P	WDR72_uc010bfi.1_Missense_Mutation_p.Q779P	NM_182758	NP_877435	Q3MJ13	WDR72_HUMAN	WD repeat domain 72	779										lung(1)|skin(1)	2				all cancers(107;0.0511)		TGGCTTAGGCTGCATTTTTTT	0.383			NA											22	102					0	0	0.00278	0	0
CILP	8483	broad.mit.edu	37	15	65494368	65494368	+	Splice_Site	SNP	C	C	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr15:65494368C>T	uc002aon.2	-	8	1210	c.1029_splice	c.e8-1	p.W343_splice		NM_003613	NP_003604	O75339	CILP1_HUMAN	cartilage intermediate layer protein						negative regulation of insulin-like growth factor receptor signaling pathway	extracellular matrix part|extracellular space|proteinaceous extracellular matrix				ovary(4)|pancreas(2)|skin(1)	7						ATTATGATACCTGCAAGGGAT	0.527			NA											6	39					0	0	0.001984	0	0
IGDCC4	57722	broad.mit.edu	37	15	65676739	65676739	+	Missense_Mutation	SNP	A	A	G			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr15:65676739A>G	uc002aou.1	-	20	3571	c.3361T>C	c.(3361-3363)TCA>CCA	p.S1121P	IGDCC4_uc002aot.1_Missense_Mutation_p.S709P	NM_020962	NP_066013	Q8TDY8	IGDC4_HUMAN	immunoglobulin superfamily, DCC subclass, member	1121	Cytoplasmic (Potential).					integral to membrane|plasma membrane				ovary(1)|pancreas(1)|skin(1)	3						GCTGGGGGTGACTTCTTCCTC	0.512			NA											18	68					0	0	0.00333	0	0
SMAD6	4091	broad.mit.edu	37	15	67073688	67073688	+	Missense_Mutation	SNP	A	A	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr15:67073688A>T	uc002aqf.2	+	4	2229	c.1306A>T	c.(1306-1308)ATC>TTC	p.I436F	SMAD6_uc010bhx.2_RNA|SMAD6_uc002aqg.2_Missense_Mutation_p.I175F	NM_005585	NP_005576	O43541	SMAD6_HUMAN	SMAD family member 6 isoform 1	436	MH2.				BMP signaling pathway|immune response|negative regulation of apoptosis|negative regulation of BMP signaling pathway|negative regulation of caspase activity|negative regulation of pathway-restricted SMAD protein phosphorylation|negative regulation of SMAD protein complex assembly|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of S phase of mitotic cell cycle|response to laminar fluid shear stress|transforming growth factor beta receptor signaling pathway|zygotic specification of dorsal/ventral axis	cytosol|transcription factor complex	co-SMAD binding|I-SMAD binding|R-SMAD binding|sequence-specific DNA binding transcription factor activity|transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity|type I activin receptor binding|type I transforming growth factor beta receptor binding|ubiquitin protein ligase binding			skin(1)	1						CGGCTACTCCATCAAGGTGTT	0.721	Esophageal Squamous(179;72 2004 22333 39628 47290)		NA											4	14					0	0	0.009096	0	0
NEO1	4756	broad.mit.edu	37	15	73545747	73545747	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr15:73545747G>A	uc002avm.3	+	12	2043	c.1901G>A	c.(1900-1902)AGT>AAT	p.S634N	NEO1_uc010ukx.1_Missense_Mutation_p.S634N|NEO1_uc010uky.1_Missense_Mutation_p.S634N|NEO1_uc010ukz.1_Missense_Mutation_p.S58N|NEO1_uc002avn.3_Missense_Mutation_p.S299N	NM_002499	NP_002490	Q92859	NEO1_HUMAN	neogenin homolog 1 precursor	634	Extracellular (Potential).|Fibronectin type-III 3.				axon guidance|cell adhesion|positive regulation of muscle cell differentiation	Golgi apparatus|integral to plasma membrane|nucleus				pancreas(1)	1						CTAGTTCCCAGTGCTGCTCCT	0.373			NA											8	22					0	0	0.006214	0	0
LMAN1L	79748	broad.mit.edu	37	15	75114169	75114169	+	Splice_Site	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr15:75114169G>T	uc002ayt.1	+	10	1062	c.1060_splice	c.e10-1	p.A354_splice	LMAN1L_uc010bke.1_Splice_Site_p.A342_splice	NM_021819	NP_068591	Q9HAT1	LMA1L_HUMAN	lectin, mannose-binding, 1 like precursor							ER-Golgi intermediate compartment membrane|integral to membrane	sugar binding				0						CCTATCCCCAGGCCCTGGATG	0.572			NA											11	60					6.40141e-05	7.28859e-05	0.000978	1	0
C15orf39	56905	broad.mit.edu	37	15	75499772	75499772	+	Silent	SNP	C	C	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr15:75499772C>T	uc002azp.3	+	2	1703	c.1383C>T	c.(1381-1383)CCC>CCT	p.P461P	C15orf39_uc002azq.3_Silent_p.P461P|C15orf39_uc002azr.3_5'Flank	NM_015492	NP_056307	Q6ZRI6	CO039_HUMAN	hypothetical protein LOC56905	461											0						CTGGGCCGCCCATCGTCATCC	0.652			NA											14	32					0	0	0.007413	0	0
CSPG4	1464	broad.mit.edu	37	15	75981130	75981130	+	Missense_Mutation	SNP	A	A	G			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr15:75981130A>G	uc002baw.2	-	3	2369	c.2276T>C	c.(2275-2277)CTG>CCG	p.L759P		NM_001897	NP_001888	Q6UVK1	CSPG4_HUMAN	chondroitin sulfate proteoglycan 4 precursor	759	CSPG 3.|Extracellular (Potential).|Gly/Ser-rich (glycosaminoglycan attachment domain).|Interaction with COL5A1 (By similarity).|Interaction with COL6A2 (By similarity).				angiogenesis|cell differentiation|intracellular signal transduction|positive regulation of peptidyl-tyrosine phosphorylation|tissue remodeling	apical plasma membrane|cell surface|integral to plasma membrane|intracellular|lamellipodium membrane	protein kinase binding|signal transducer activity			ovary(2)|pancreas(1)	3						CTCCAGGGCCAGGTTCTCCAC	0.637			NA											7	19					0	0	0.00308	0	0
ACSBG1	23205	broad.mit.edu	37	15	78487043	78487043	+	Silent	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr15:78487043G>T	uc002bdh.2	-	3	314	c.258C>A	c.(256-258)GCC>GCA	p.A86A	ACSBG1_uc010umw.1_Silent_p.A86A|ACSBG1_uc010umx.1_Intron|ACSBG1_uc010umy.1_5'UTR	NM_015162	NP_055977	Q96GR2	ACBG1_HUMAN	lipidosin	86					long-chain fatty acid metabolic process|myelination|very long-chain fatty acid metabolic process	cytoplasmic membrane-bounded vesicle|endoplasmic reticulum|microsome	ATP binding|long-chain fatty acid-CoA ligase activity|very long-chain fatty acid-CoA ligase activity			ovary(1)	1						CCCGCCCATCGGCCCGAGTCG	0.642			NA											15	59					0.000566183	0.000622257	0.00499	1	0
CHRNA5	1138	broad.mit.edu	37	15	78882901	78882901	+	Missense_Mutation	SNP	A	A	G			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr15:78882901A>G	uc002bdy.2	+	5	1330	c.1168A>G	c.(1168-1170)AGA>GGA	p.R390G	CHRNA5_uc002bdz.2_Intron	NM_000745	NP_000736	P30532	ACHA5_HUMAN	cholinergic receptor, nicotinic, alpha 5	390	Cytoplasmic (Potential).				behavioral response to nicotine	cell junction|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity			ovary(1)|central_nervous_system(1)|skin(1)	3						AAAATCTTCTAGAAACACATT	0.418			NA											14	25					0	0	0.004007	0	0
IL16	3603	broad.mit.edu	37	15	81592569	81592569	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr15:81592569C>T	uc002bgh.3	+	14	3278	c.2902C>T	c.(2902-2904)CCC>TCC	p.P968S	IL16_uc010blq.1_Missense_Mutation_p.P922S|IL16_uc002bge.3_RNA|IL16_uc010unp.1_Missense_Mutation_p.P1010S|IL16_uc002bgg.2_Missense_Mutation_p.P968S|IL16_uc002bgi.1_Missense_Mutation_p.P358S|IL16_uc002bgj.2_Missense_Mutation_p.P462S|IL16_uc002bgk.2_Missense_Mutation_p.P267S|IL16_uc002bgl.1_Missense_Mutation_p.P267S|IL16_uc010unq.1_Missense_Mutation_p.P267S	NM_172217	NP_757366	Q14005	IL16_HUMAN	interleukin 16 isoform 2	968					immune response|interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|extracellular space|nucleus|plasma membrane	cytokine activity			ovary(2)|lung(1)|skin(1)	4						ACGGAGCTTCCCCCTGACCAG	0.572			NA											5	22					0	0	0.000602	0	0
ADAMTSL3	57188	broad.mit.edu	37	15	84561559	84561559	+	Nonsense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr15:84561559C>A	uc002bjz.3	+	13	1610	c.1386C>A	c.(1384-1386)TGC>TGA	p.C462*	ADAMTSL3_uc010bmt.1_Nonsense_Mutation_p.C462*|ADAMTSL3_uc010bmu.1_Nonsense_Mutation_p.C462*	NM_207517	NP_997400	P82987	ATL3_HUMAN	ADAMTS-like 3 precursor	462	TSP type-1 2.					proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			ovary(6)|central_nervous_system(5)|lung(5)|large_intestine(4)|breast(3)|skin(2)|kidney(1)|pancreas(1)	27			BRCA - Breast invasive adenocarcinoma(143;0.211)			AATGGAAGTGCATGTACGCAC	0.473			NA											8	21					1.58986e-06	1.94739e-06	0.008291	1	0
ANPEP	290	broad.mit.edu	37	15	90335755	90335755	+	Missense_Mutation	SNP	T	T	C			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr15:90335755T>C	uc002bop.3	-	17	2580	c.2288A>G	c.(2287-2289)AAC>AGC	p.N763S		NM_001150	NP_001141	P15144	AMPN_HUMAN	membrane alanine aminopeptidase precursor	763	Extracellular.|Metalloprotease.				angiogenesis|cell differentiation|interspecies interaction between organisms	cytosol|ER-Golgi intermediate compartment|integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|receptor activity|zinc ion binding			ovary(3)|skin(1)	4	Lung NSC(78;0.0221)|all_lung(78;0.0448)		BRCA - Breast invasive adenocarcinoma(143;0.0146)|KIRC - Kidney renal clear cell carcinoma(17;0.0286)|Kidney(142;0.0514)|STAD - Stomach adenocarcinoma(125;0.169)		Ezetimibe(DB00973)	TGGAACTCCGTTGGAGCAGGC	0.577	NSCLC(30;827 977 2459 19669 26125)		NA											5	54					0	0	0.000602	0	0
SV2B	9899	broad.mit.edu	37	15	91769718	91769719	+	Missense_Mutation	DNP	GG	GG	TT			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr15:91769718_91769719GG>TT	uc002bqv.2	+	1	616_617	c.225_226GG>TT	c.(223-228)CGGGGC>CGTTGC	p.G76C	SV2B_uc002bqt.2_Missense_Mutation_p.G76C|SV2B_uc010uqv.1_Intron|SV2B_uc002bqu.3_RNA	NM_014848	NP_055663	Q7L1I2	SV2B_HUMAN	synaptic vesicle protein 2B homolog	76	Cytoplasmic (Potential).				neurotransmitter transport	acrosomal vesicle|cell junction|integral to membrane|synaptic vesicle membrane	transmembrane transporter activity			ovary(3)|central_nervous_system(2)|skin(2)|upper_aerodigestive_tract(1)	8	Lung NSC(78;0.0987)|all_lung(78;0.172)		BRCA - Breast invasive adenocarcinoma(143;0.0895)			ACAGCCTTCGGGGCCAGACAGA	0.584			NA											7	17					0	0	0.004672	0	0
TPSD1	23430	broad.mit.edu	37	16	1306591	1306591	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr16:1306591G>T	uc002clb.1	+	2	166	c.157G>T	c.(157-159)GTG>TTG	p.V53L	TPSD1_uc010brm.1_5'UTR	NM_012217	NP_036349	Q9BZJ3	TRYD_HUMAN	tryptase delta 1 precursor	53	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity				0		Hepatocellular(780;0.00369)				GCCCTGGCAGGTGAGCCTGAG	0.692			NA											24	56					6.12954e-19	1.00492e-18	0.004656	1	0
HAGH	3029	broad.mit.edu	37	16	1872979	1872979	+	Nonsense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr16:1872979C>A	uc002cna.2	-	2	543	c.136G>T	c.(136-138)GAG>TAG	p.E46*	HAGH_uc002cmz.2_5'UTR|HAGH_uc010uvp.1_Nonsense_Mutation_p.E46*|HAGH_uc002cnb.1_5'UTR|HAGH_uc010bry.1_Nonsense_Mutation_p.E46*	NM_005326	NP_005317	Q16775	GLO2_HUMAN	hydroxyacylglutathione hydrolase isoform 1	46					glutathione biosynthetic process	cytoplasm|mitochondrial matrix|mitochondrial matrix	hydroxyacylglutathione hydrolase activity|zinc ion binding			ovary(1)	1		Hepatocellular(780;0.00335)			Glutathione(DB00143)	ATGGTGCCCTCGTCCACGGTC	0.587	Pancreas(55;1048 1176 25227 40124 41333)		NA											36	94					7.91308e-09	1.04873e-08	0.006999	1	0
RPL3L	6123	broad.mit.edu	37	16	1995919	1995919	+	Missense_Mutation	SNP	G	G	T	rs143428526		TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr16:1995919G>T	uc002cnh.2	-	8	1011	c.964C>A	c.(964-966)CAC>AAC	p.H322N	SEPX1_uc010uvs.1_5'Flank	NM_005061	NP_005052	Q92901	RL3L_HUMAN	ribosomal protein L3-like	322					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosol|ribosome	RNA binding|structural constituent of ribosome				0						TCCCCGTAGTGGGGGAAGCCA	0.597			NA											19	63					1.22574e-08	1.61871e-08	0.002299	1	0
TSC2	7249	broad.mit.edu	37	16	2115637	2115637	+	Splice_Site	SNP	G	G	T	rs45517190		TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr16:2115637G>T	uc002con.2	+	16	1822	c.1716_splice	c.e16+1	p.Q572_splice	TSC2_uc010bsd.2_Splice_Site_p.Q572_splice|TSC2_uc002coo.2_Splice_Site_p.Q572_splice|TSC2_uc010uvv.1_Splice_Site_p.Q535_splice|TSC2_uc010uvw.1_Splice_Site_p.Q523_splice|TSC2_uc002cop.2_Splice_Site_p.Q372_splice	NM_000548	NP_000539	P49815	TSC2_HUMAN	tuberous sclerosis 2 isoform 1						cell cycle arrest|endocytosis|heart development|insulin receptor signaling pathway|insulin-like growth factor receptor signaling pathway|negative regulation of cell size|negative regulation of phosphatidylinositol 3-kinase cascade|negative regulation of protein kinase B signaling cascade|negative regulation of TOR signaling cascade|negative regulation of Wnt receptor signaling pathway|nerve growth factor receptor signaling pathway|neural tube closure|phosphatidylinositol-mediated signaling|positive chemotaxis|protein import into nucleus|protein kinase B signaling cascade|regulation of endocytosis|regulation of insulin receptor signaling pathway|regulation of small GTPase mediated signal transduction	Golgi apparatus|nucleus|perinuclear region of cytoplasm|TSC1-TSC2 complex	GTPase activator activity|protein homodimerization activity			central_nervous_system(4)|lung(3)|ovary(2)|pancreas(1)	10		Hepatocellular(780;0.0202)				CATCCTTCAGGTGGGTGTTCT	0.642			NA	D|Mis|N|F|S			hamartoma|renal cell			Tuberous_Sclerosis				18	52					1.10513e-12	1.63842e-12	0.002299	1	0
C16orf90	646174	broad.mit.edu	37	16	3544669	3544669	+	Silent	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr16:3544669G>T	uc002cvi.2	-	2	255	c.255C>A	c.(253-255)GGC>GGA	p.G85G		NM_001080524	NP_001073993	A8MZG2	CP090_HUMAN	hypothetical protein LOC646174	75											0						CCATAAGCCGGCCCAGCCAGT	0.692			NA											6	13					0.00307968	0.00328514	0.00308	1	0
UBN1	29855	broad.mit.edu	37	16	4924688	4924688	+	Silent	SNP	C	C	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr16:4924688C>T	uc002cyb.2	+	15	2616	c.2277C>T	c.(2275-2277)GGC>GGT	p.G759G	UBN1_uc010uxw.1_Silent_p.G759G|UBN1_uc002cyc.2_Silent_p.G759G	NM_001079514	NP_001072982	Q9NPG3	UBN1_HUMAN	ubinuclein 1	759					chromatin modification|interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter	PML body|tight junction	DNA binding|sequence-specific DNA binding transcription factor activity			skin(2)	2						AGAGTTCTGGCTACAAAGAGC	0.562			NA											16	37					0	0	0.00499	0	0
C16orf45	89927	broad.mit.edu	37	16	15677094	15677094	+	Silent	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr16:15677094C>A	uc002ddo.2	+	5	687	c.501C>A	c.(499-501)GCC>GCA	p.A167A	C16orf45_uc002ddp.2_Silent_p.A150A	NM_033201	NP_149978	Q96MC5	CP045_HUMAN	hypothetical protein LOC89927 isoform 1	167										ovary(1)	1						AATCTCCAGCCAGTGAGTATA	0.303			NA											22	66					3.5997e-14	5.46757e-14	0.002299	1	0
MYH11	4629	broad.mit.edu	37	16	15851831	15851831	+	Silent	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr16:15851831G>T	uc002ddy.2	-	13	1535	c.1428C>A	c.(1426-1428)ATC>ATA	p.I476I	MYH11_uc002ddv.2_Silent_p.I483I|MYH11_uc002ddw.2_Silent_p.I476I|MYH11_uc002ddx.2_Silent_p.I483I|MYH11_uc010bvg.2_Silent_p.I308I|MYH11_uc002dea.1_Silent_p.I182I	NM_002474	NP_002465	P35749	MYH11_HUMAN	smooth muscle myosin heavy chain 11 isoform	476	Myosin head-like.				axon guidance|cardiac muscle fiber development|elastic fiber assembly|skeletal muscle myosin thick filament assembly|smooth muscle contraction	cytosol|melanosome|muscle myosin complex|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			ovary(6)|skin(3)|lung(2)|breast(2)|upper_aerodigestive_tract(1)|pancreas(1)	15						TGGTGTAGTTGATGCACAGCT	0.567			NA	T	CBFB	AML								26	72					1.56442e-22	2.66776e-22	0.002445	1	0
TMC5	79838	broad.mit.edu	37	16	19485485	19485485	+	Missense_Mutation	SNP	A	A	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr16:19485485A>T	uc002dgc.3	+	12	2726	c.1977A>T	c.(1975-1977)TTA>TTT	p.L659F	TMC5_uc010vaq.1_Missense_Mutation_p.L607F|TMC5_uc002dgb.3_Missense_Mutation_p.L659F|TMC5_uc010var.1_Missense_Mutation_p.L659F|TMC5_uc002dgd.1_Missense_Mutation_p.L413F|TMC5_uc002dge.3_Missense_Mutation_p.L413F|TMC5_uc002dgf.3_Missense_Mutation_p.L342F|TMC5_uc002dgg.3_Missense_Mutation_p.L300F	NM_001105248	NP_001098718	Q6UXY8	TMC5_HUMAN	transmembrane channel-like 5 isoform a	659	Helical; (Potential).					integral to membrane				skin(1)	1						CGGTGCTGTTACTGCCTTTCG	0.552			NA											53	134					0	0	0.00361	0	0
GP2	2813	broad.mit.edu	37	16	20335338	20335338	+	Missense_Mutation	SNP	C	C	A	rs147629855	by1000genomes	TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr16:20335338C>A	uc002dgv.2	-	3	418	c.335G>T	c.(334-336)CGA>CTA	p.R112L	GP2_uc002dgw.2_Missense_Mutation_p.R112L|GP2_uc002dgx.2_Intron|GP2_uc002dgy.2_Intron	NM_001007240	NP_001007241	P55259	GP2_HUMAN	zymogen granule membrane glycoprotein 2 isoform	112						anchored to membrane|extracellular region|plasma membrane				ovary(3)|skin(1)	4						TGTCTGGCATCGGTGCACCTG	0.597			NA											23	58					7.92952e-12	1.14812e-11	0.003954	1	0
PDILT	204474	broad.mit.edu	37	16	20373839	20373839	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr16:20373839G>T	uc002dhc.1	-	10	1526	c.1303C>A	c.(1303-1305)CAA>AAA	p.Q435K		NM_174924	NP_777584	Q8N807	PDILT_HUMAN	protein disulfide isomerase-like, testis	435	Thioredoxin.				cell differentiation|cell redox homeostasis|multicellular organismal development|spermatogenesis	endoplasmic reticulum	isomerase activity			large_intestine(1)	1						GAGTGGTTTTGATATTTTCTG	0.478			NA											17	37					3.32936e-07	4.1603e-07	0.006122	1	0
ACSM5	54988	broad.mit.edu	37	16	20448427	20448427	+	Silent	SNP	G	G	C			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr16:20448427G>C	uc002dhe.2	+	11	1509	c.1362G>C	c.(1360-1362)GGG>GGC	p.G454G		NM_017888	NP_060358	Q6NUN0	ACSM5_HUMAN	acyl-CoA synthetase medium-chain family member 5	454					fatty acid metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|GTP binding|metal ion binding			ovary(2)	2						ACATCACAGGGGACCGAGCTC	0.488			NA											19	70					0	0	0.001882	0	0
ACSM2A	123876	broad.mit.edu	37	16	20476923	20476923	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr16:20476923G>A	uc010bwe.2	+	4	501	c.262G>A	c.(262-264)GAA>AAA	p.E88K	ACSM2A_uc010bwd.1_RNA|ACSM2A_uc010vax.1_Missense_Mutation_p.E9K|ACSM2A_uc002dhf.3_Missense_Mutation_p.E88K|ACSM2A_uc002dhg.3_Missense_Mutation_p.E88K|ACSM2A_uc010vay.1_Missense_Mutation_p.E9K	NM_001010845	NP_001010845	Q08AH3	ACS2A_HUMAN	acyl-CoA synthetase medium-chain family member	88					fatty acid metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|metal ion binding			skin(2)|breast(1)	3						AGAACTGAGTGAAAACAGCCA	0.597			NA											12	51					0	0	0.001368	0	0
ACSM2A	123876	broad.mit.edu	37	16	20477017	20477017	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr16:20477017G>T	uc010bwe.2	+	4	595	c.356G>T	c.(355-357)TGG>TTG	p.W119L	ACSM2A_uc010bwd.1_RNA|ACSM2A_uc010vax.1_Missense_Mutation_p.W40L|ACSM2A_uc002dhf.3_Missense_Mutation_p.W119L|ACSM2A_uc002dhg.3_Missense_Mutation_p.W119L|ACSM2A_uc010vay.1_Missense_Mutation_p.W40L	NM_001010845	NP_001010845	Q08AH3	ACS2A_HUMAN	acyl-CoA synthetase medium-chain family member	119					fatty acid metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|metal ion binding			skin(2)|breast(1)	3						GTGCCTGAGTGGTGGCTGGTG	0.572			NA											10	33					1.36491e-13	2.04599e-13	0.001855	1	0
VWA3A	146177	broad.mit.edu	37	16	22128452	22128452	+	Silent	SNP	A	A	C			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr16:22128452A>C	uc010vbq.1	+	11	1041	c.945A>C	c.(943-945)GCA>GCC	p.A315A	VWA3A_uc010bxc.2_Silent_p.A302A	NM_173615	NP_775886	A6NCI4	VWA3A_HUMAN	von Willebrand factor A domain containing 3A	315						extracellular region				skin(1)	1				GBM - Glioblastoma multiforme(48;0.0439)		AGAACCTTGCAGAAGCTGTTA	0.547			NA											3	3					0	0	0.004672	0	0
LCMT1	51451	broad.mit.edu	37	16	25143815	25143815	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr16:25143815G>A	uc002dnx.1	+	3	456	c.298G>A	c.(298-300)GGC>AGC	p.G100S	LCMT1_uc002dny.1_Missense_Mutation_p.G100S|LCMT1_uc002dnz.1_5'UTR|LCMT1_uc002doa.1_5'UTR	NM_016309	NP_057393	Q9UIC8	LCMT1_HUMAN	leucine carboxyl methyltransferase 1 isoform a	100							protein binding|protein C-terminal carboxyl O-methyltransferase activity|S-adenosylmethionine-dependent methyltransferase activity				0				GBM - Glioblastoma multiforme(48;0.0336)	L-Leucine(DB00149)	CCTTGGGGCAGGCATGGATAC	0.428	Colon(200;565 2072 24396 47922 50898)		NA											7	24					0	0	0.00308	0	0
IL21R	50615	broad.mit.edu	37	16	27455868	27455868	+	Silent	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr16:27455868G>T	uc002doq.1	+	6	746	c.513G>T	c.(511-513)CCG>CCT	p.P171P	IL21R_uc002dor.1_Silent_p.P171P|IL21R_uc002dos.1_Silent_p.P171P	NM_181078	NP_851564	Q9HBE5	IL21R_HUMAN	interleukin 21 receptor precursor	171	Extracellular (Potential).|Fibronectin type-III.				natural killer cell activation	integral to membrane	interleukin-21 receptor activity			ovary(2)|lung(1)|breast(1)	4						GGCAGAGTCCGAGGAGAAAGC	0.582			NA	T	BCL6	NHL								12	24					0.00185496	0.00200605	0.001855	1	0
GSG1L	146395	broad.mit.edu	37	16	27840137	27840137	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr16:27840137G>T	uc002doz.2	-	5	888	c.803C>A	c.(802-804)CCT>CAT	p.P268H	GSG1L_uc010bya.1_Missense_Mutation_p.P217H|GSG1L_uc010bxz.1_Missense_Mutation_p.P113H|GSG1L_uc002doy.2_Missense_Mutation_p.P113H	NM_001109763	NP_001103233	Q6UXU4	GSG1L_HUMAN	GSG1-like isoform 1	268						integral to membrane				ovary(1)	1						GATGGCCTCAGGGTCTATGAA	0.607			NA											26	40					6.04164e-23	1.03145e-22	0.002096	1	0
EIF3CL	728689	broad.mit.edu	37	16	28734788	28734788	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr16:28734788C>G	uc010byj.2	+	11	1048	c.959C>G	c.(958-960)GCC>GGC	p.A320G	uc010vct.1_Intron|EIF3CL_uc010byi.2_Missense_Mutation_p.A319G|EIF3CL_uc002dqs.3_Missense_Mutation_p.A319G|EIF3C_uc002dqt.3_Missense_Mutation_p.A319G|EIF3CL_uc010vcy.1_Missense_Mutation_p.A309G|EIF3C_uc002dqu.3_Missense_Mutation_p.A319G|EIF3CL_uc002dqv.3_Missense_Mutation_p.A65G	NM_001099661	NP_001093131	B5ME19	B5ME19_HUMAN	eukaryotic translation initiation factor 3,	320						eukaryotic translation initiation factor 3 complex	translation initiation factor activity				0						AAAATGTTTGCCAAGGGAACT	0.493			NA											56	187					0	0	0.00361	0	0
ITGAL	3683	broad.mit.edu	37	16	30505629	30505629	+	Missense_Mutation	SNP	A	A	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr16:30505629A>T	uc002dyi.3	+	12	1486	c.1310A>T	c.(1309-1311)CAA>CTA	p.Q437L	ITGAL_uc002dyj.3_Missense_Mutation_p.Q354L|ITGAL_uc010vev.1_Intron	NM_002209	NP_002200	P20701	ITAL_HUMAN	integrin alpha L isoform a precursor	437	FG-GAP 4.|Extracellular (Potential).				blood coagulation|heterophilic cell-cell adhesion|inflammatory response|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|regulation of immune response|T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell	integrin complex	cell adhesion molecule binding|receptor activity			ovary(3)|lung(3)|central_nervous_system(3)|breast(1)	10					Efalizumab(DB00095)	CTGCTGTTCCAAGAGCCACAG	0.647	NSCLC(110;1462 1641 3311 33990 49495)		NA											13	30					0	0	0.001855	0	0
SETD1A	9739	broad.mit.edu	37	16	30982946	30982946	+	Silent	SNP	G	G	C			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr16:30982946G>C	uc002ead.1	+	13	3950	c.3264G>C	c.(3262-3264)ACG>ACC	p.T1088T		NM_014712	NP_055527	O15047	SET1A_HUMAN	SET domain containing 1A	1088	Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nuclear speck|Set1C/COMPASS complex	histone-lysine N-methyltransferase activity|nucleotide binding|protein binding|RNA binding			ovary(2)|skin(1)	3						CAGTGCCCACGCCAGCACCTG	0.622			NA											12	55					0	0	0.006122	0	0
SETD1A	9739	broad.mit.edu	37	16	30991034	30991034	+	Silent	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr16:30991034G>T	uc002ead.1	+	14	4613	c.3927G>T	c.(3925-3927)ACG>ACT	p.T1309T		NM_014712	NP_055527	O15047	SET1A_HUMAN	SET domain containing 1A	1309					regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nuclear speck|Set1C/COMPASS complex	histone-lysine N-methyltransferase activity|nucleotide binding|protein binding|RNA binding			ovary(2)|skin(1)	3						TCAAGCCCACGCCCCCTGCGC	0.706			NA											10	13					3.07112e-06	3.69777e-06	0.000978	1	0
ITGAM	3684	broad.mit.edu	37	16	31309101	31309101	+	Silent	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr16:31309101G>T	uc002ebq.2	+	14	1631	c.1533G>T	c.(1531-1533)GGG>GGT	p.G511G	ITGAM_uc002ebr.2_Silent_p.G512G|ITGAM_uc010cam.1_Intron|ITGAM_uc010can.2_Intron	NM_000632	NP_000623	P11215	ITAM_HUMAN	integrin alpha M isoform 2 precursor	511	FG-GAP 6.|Extracellular (Potential).				blood coagulation|cell adhesion|integrin-mediated signaling pathway|leukocyte migration	integrin complex	glycoprotein binding|receptor activity			kidney(1)	1						TTCTCTACGGGGAGCAGGGCC	0.652			NA											20	46					1.55795e-14	2.38095e-14	0.001882	1	0
ZNF720	124411	broad.mit.edu	37	16	31734648	31734648	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr16:31734648G>T	uc002ecn.3	+	3	404	c.200G>T	c.(199-201)AGT>ATT	p.S67I	ZNF720_uc010vfs.1_5'UTR|ZNF720_uc002eco.2_Intron|ZNF720_uc002ecp.1_Intron|ZNF720_uc002ecq.2_Missense_Mutation_p.S69I	NM_001130913	NP_001124385	Q7Z2F6	ZN720_HUMAN	zinc finger protein 720	67	KRAB.				regulation of transcription, DNA-dependent	intracellular	nucleic acid binding				0						AATGTGAAGAGTGCAGAGACA	0.473			NA											10	11					7.03913e-09	9.3457e-09	0.001368	1	0
CYLD	1540	broad.mit.edu	37	16	50830247	50830247	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr16:50830247G>T	uc002egp.1	+	19	3114	c.2699G>T	c.(2698-2700)GGC>GTC	p.G900V	CYLD_uc002egq.1_Missense_Mutation_p.G897V|CYLD_uc002egr.1_Missense_Mutation_p.G897V	NM_015247	NP_056062	Q9NQC7	CYLD_HUMAN	ubiquitin carboxyl-terminal hydrolase CYLD	900					cell cycle|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production|protein K63-linked deubiquitination|regulation of microtubule cytoskeleton organization|regulation of mitotic cell cycle|translation|ubiquitin-dependent protein catabolic process|Wnt receptor signaling pathway	cytosol|extrinsic to internal side of plasma membrane|microtubule|perinuclear region of cytoplasm|ribosome	proline-rich region binding|protein kinase binding|structural constituent of ribosome|ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			skin(19)|large_intestine(3)|haematopoietic_and_lymphoid_tissue(3)|central_nervous_system(3)	28		all_cancers(37;0.0156)				GGTCAGAATGGCTTCAACATT	0.448			NA	Mis|N|F|S		cylindroma	cylindroma			Familial_Cylindromatosis|Multiple_Trichoepithelioma_Familial				5	46					4.096e-09	5.49211e-09	0.001168	1	0
CES1	1066	broad.mit.edu	37	16	55857462	55857462	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr16:55857462C>A	uc002eim.2	-	4	644	c.536G>T	c.(535-537)AGC>ATC	p.S179I	CES1_uc002eil.2_Missense_Mutation_p.S180I|CES1_uc002ein.2_Missense_Mutation_p.S179I	NM_001025194	NP_001020365	P23141	EST1_HUMAN	carboxylesterase 1 isoform b precursor	179					response to toxin	endoplasmic reticulum lumen	carboxylesterase activity|methyl indole-3-acetate esterase activity|methyl jasmonate esterase activity|methyl salicylate esterase activity				0				all cancers(182;0.13)|Epithelial(162;0.137)	Aminoglutethimide(DB00357)|Bezafibrate(DB01393)|Cholestyramine(DB01432)|Moexipril(DB00691)	GATTTCTTACCTGAAGAATCC	0.562	NSCLC(162;1801 2756 42904 52896)		NA											13	40					9.16793e-09	1.2118e-08	0.00499	1	0
NLRC5	84166	broad.mit.edu	37	16	57110788	57110788	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr16:57110788G>T	uc002ekk.1	+	40	5034	c.4809G>T	c.(4807-4809)AGG>AGT	p.R1603S	NLRC5_uc010ccr.1_RNA|NLRC5_uc010ccs.1_RNA|NLRC5_uc002eko.1_RNA|NLRC5_uc002ekq.1_Missense_Mutation_p.R145S|NLRC5_uc002ekr.1_Missense_Mutation_p.R490S	NM_032206	NP_115582	Q86WI3	NLRC5_HUMAN	nucleotide-binding oligomerization domains 27	1603					defense response to virus|innate immune response|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production|negative regulation of type I interferon-mediated signaling pathway|positive regulation of interferon-gamma-mediated signaling pathway|positive regulation of MHC class I biosynthetic process|positive regulation of transcription from RNA polymerase II promoter|positive regulation of type I interferon-mediated signaling pathway|regulation of kinase activity	cytosol|nucleus	ATP binding|protein binding|RNA polymerase II core promoter sequence-specific DNA binding			ovary(4)|skin(2)|breast(1)	7		all_neural(199;0.225)				AGGCTCTCAGGGCTGCCACCA	0.552			NA											7	46					2.17888e-05	2.52532e-05	0.006214	1	0
CMTM2	146225	broad.mit.edu	37	16	66613615	66613615	+	Silent	SNP	G	G	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr16:66613615G>A	uc002ept.2	+	1	265	c.105G>A	c.(103-105)TCG>TCA	p.S35S	CMTM2_uc010cdu.2_Silent_p.S35S	NM_144673	NP_653274	Q8TAZ6	CKLF2_HUMAN	chemokine-like factor superfamily 2	35					chemotaxis	extracellular space|integral to membrane	cytokine activity			ovary(1)	1		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.068)|Epithelial(162;0.212)		AGGAGCCATCGGACAAACCTC	0.617			NA											6	62					0	0	0.00308	0	0
HYDIN	54768	broad.mit.edu	37	16	70977764	70977764	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr16:70977764C>A	uc002ezr.2	-	42	6745	c.6617G>T	c.(6616-6618)TGT>TTT	p.C2206F		NM_032821	NP_116210	Q4G0P3	HYDIN_HUMAN	hydrocephalus inducing isoform a	2207										ovary(1)|skin(1)	2		Ovarian(137;0.0654)				CGGGAGCACACAGCTCATCAG	0.577			NA											10	24					2.27111e-07	2.85232e-07	0.001368	1	0
AP1G1	164	broad.mit.edu	37	16	71823291	71823291	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr16:71823291C>A	uc010cgg.2	-	2	406	c.92G>T	c.(91-93)TGT>TTT	p.C31F	AP1G1_uc002fba.2_Missense_Mutation_p.C31F|AP1G1_uc002fbb.2_Missense_Mutation_p.C54F|AP1G1_uc010vmg.1_RNA|AP1G1_uc010vmh.1_Missense_Mutation_p.C113F	NM_001128	NP_001119	O43747	AP1G1_HUMAN	adaptor-related protein complex 1, gamma 1	31					endocytosis|intracellular protein transport|post-Golgi vesicle-mediated transport|regulation of defense response to virus by virus|viral reproduction	clathrin adaptor complex|clathrin coated vesicle membrane|cytosol|Golgi membrane|lysosomal membrane|recycling endosome	kinesin binding|protein transporter activity			ovary(2)	2		Ovarian(137;0.125)				GATTGCAGCACATTCTTTCTG	0.502			NA											20	52					9.57634e-11	1.3434e-10	0.00333	1	0
DHX38	9785	broad.mit.edu	37	16	72141433	72141433	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr16:72141433C>T	uc002fcb.2	+	20	3150	c.2795C>T	c.(2794-2796)GCC>GTC	p.A932V	DHX38_uc010vmp.1_Missense_Mutation_p.A244V	NM_014003	NP_054722	Q92620	PRP16_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 38	932					mRNA 3'-end processing|mRNA export from nucleus|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	catalytic step 2 spliceosome|nucleoplasm	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			skin(1)	1		Ovarian(137;0.125)				ATCCTCGGGGCCCTGGACAAC	0.597	Melanoma(97;711 1442 7855 13832 28836)		NA											9	21					0	0	0.008291	0	0
ZFHX3	463	broad.mit.edu	37	16	72991600	72991600	+	Silent	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr16:72991600C>A	uc002fck.2	-	2	3118	c.2445G>T	c.(2443-2445)GTG>GTT	p.V815V	ZFHX3_uc002fcl.2_Intron	NM_006885	NP_008816	Q15911	ZFHX3_HUMAN	zinc finger homeobox 3 isoform A	815	C2H2-type 5; atypical.				muscle organ development|negative regulation of myoblast differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|positive regulation of myoblast differentiation	transcription factor complex	enzyme binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(2)|skin(2)	4		Ovarian(137;0.13)				GGTTCCTGGCCACGTTGGTCT	0.522			NA											30	104					4.74835e-14	7.16833e-14	0.002096	1	0
GLG1	2734	broad.mit.edu	37	16	74537629	74537629	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr16:74537629C>G	uc002fcy.3	-	4	624	c.574G>C	c.(574-576)GAT>CAT	p.D192H	GLG1_uc002fcx.2_Missense_Mutation_p.D192H|GLG1_uc002fcw.3_Missense_Mutation_p.D181H|GLG1_uc002fcz.3_5'UTR	NM_001145667	NP_001139139	Q92896	GSLG1_HUMAN	golgi apparatus protein 1 isoform 3	192	Cys-rich GLG1 2.|Extracellular (Potential).					Golgi membrane|integral to membrane	receptor binding			ovary(1)|breast(1)	2						ACCGGTTCATCAGCACATTCT	0.388			NA											11	51					0	0	0.001368	0	0
ADAMTS18	170692	broad.mit.edu	37	16	77401560	77401560	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr16:77401560C>A	uc002ffc.3	-	4	975	c.556G>T	c.(556-558)GCC>TCC	p.A186S	ADAMTS18_uc002ffe.1_5'UTR|ADAMTS18_uc010vni.1_RNA	NM_199355	NP_955387	Q8TE60	ATS18_HUMAN	ADAM metallopeptidase with thrombospondin type 1	186					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			large_intestine(4)|lung(4)|kidney(4)|skin(3)|breast(1)|ovary(1)|pancreas(1)	18						TGTTCCTGGGCCAGAAGCTGA	0.493			NA											17	59					5.26018e-13	7.8533e-13	0.001882	1	0
CMIP	80790	broad.mit.edu	37	16	81730228	81730228	+	Nonsense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr16:81730228G>T	uc002fgp.2	+	14	1666	c.1594G>T	c.(1594-1596)GGA>TGA	p.G532*	CMIP_uc002fgq.1_Nonsense_Mutation_p.G438*|CMIP_uc010vnq.1_Nonsense_Mutation_p.G345*|CMIP_uc002fgr.1_Nonsense_Mutation_p.G379*|CMIP_uc010vnr.1_Nonsense_Mutation_p.G98*	NM_198390	NP_938204	Q8IY22	CMIP_HUMAN	c-Maf-inducing protein isoform C-mip	498						cytoplasm|nucleus					0						CTACAGCCCCGGAGGGGTGGC	0.647			NA											10	30					9.31168e-06	1.10067e-05	0.001855	1	0
ADAD2	161931	broad.mit.edu	37	16	84229857	84229857	+	Silent	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr16:84229857G>T	uc002fhr.2	+	8	1521	c.1407G>T	c.(1405-1407)GGG>GGT	p.G469G	ADAD2_uc002fhq.2_Silent_p.G551G|uc002fhs.1_Intron	NM_001145400	NP_001138872	Q8NCV1	ADAD2_HUMAN	adenosine deaminase domain containing 2 isoform	469	A to I editase.				RNA processing	intracellular	adenosine deaminase activity|double-stranded RNA binding				0						TGTTTGCAGGGCCCCCGGTGG	0.692			NA											12	70					6.31663e-08	8.15349e-08	0.003163	1	0
KLHL36	79786	broad.mit.edu	37	16	84690791	84690791	+	Silent	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr16:84690791G>T	uc002fig.2	+	3	519	c.378G>T	c.(376-378)CTG>CTT	p.L126L	KLHL36_uc010chl.2_Silent_p.L125L	NM_024731	NP_079007	Q8N4N3	KLH36_HUMAN	kelch-like 36	126										skin(2)	2						CTCACCTGCTGCAGATCTGGA	0.602			NA											8	46					0.000274275	0.000304364	0.004482	1	0
CDH15	1013	broad.mit.edu	37	16	89245932	89245932	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr16:89245932C>A	uc002fmt.2	+	2	228	c.151C>A	c.(151-153)CCG>ACG	p.P51T	CDH15_uc010cij.1_Missense_Mutation_p.P51T	NM_004933	NP_004924	P55291	CAD15_HUMAN	cadherin 15 preproprotein	51					adherens junction organization|cell junction assembly|homophilic cell adhesion|muscle cell differentiation|positive regulation of muscle cell differentiation	integral to membrane|plasma membrane	calcium ion binding			skin(1)	1				BRCA - Breast invasive adenocarcinoma(80;0.0261)		GGTCATCCCCCCGATCAGCGT	0.687			NA											10	34					1.08611e-07	1.38156e-07	0.000978	1	0
C17orf97	400566	broad.mit.edu	37	17	263305	263305	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr17:263305G>T	uc002frh.2	+	3	717	c.701G>T	c.(700-702)GGC>GTC	p.G234V	C17orf97_uc010vpz.1_RNA	NM_001013672	NP_001013694	Q6ZQX7	CQ097_HUMAN	hypothetical protein LOC400566	234	4.|20 X 10 AA approximative tandem repeat of A-L-K-G-F-H-P-D-P-E.									ovary(1)	1						GCCCTCAAGGGCTTCCACCCC	0.697			NA											33	21					4.34086e-07	5.4197e-07	0.005524	1	0
GEMIN4	50628	broad.mit.edu	37	17	649543	649543	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr17:649543C>G	uc002frs.1	-	2	1859	c.1740G>C	c.(1738-1740)CAG>CAC	p.Q580H		NM_015721	NP_056536	P57678	GEMI4_HUMAN	gemin 4	580					rRNA processing|spliceosomal snRNP assembly	Cajal body|cytosol|nucleolus|small nuclear ribonucleoprotein complex|spliceosomal complex	protein binding			ovary(2)|kidney(1)|skin(1)	4		Myeloproliferative disorder(207;0.204)		UCEC - Uterine corpus endometrioid carcinoma (25;0.022)		CAGTGAGAATCTGGGCCAGGA	0.557			NA											25	23					0	0	0.008361	0	0
TRPV3	162514	broad.mit.edu	37	17	3417887	3417887	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr17:3417887C>T	uc002fvt.1	-	17	2600	c.2278G>A	c.(2278-2280)GAT>AAT	p.D760N	SPATA22_uc010vrg.1_5'Flank|TRPV3_uc002fvs.1_RNA|TRPV3_uc010vrh.1_Missense_Mutation_p.D744N|TRPV3_uc010vri.1_Missense_Mutation_p.D715N|TRPV3_uc010vrj.1_Missense_Mutation_p.D744N|TRPV3_uc010vrk.1_RNA|TRPV3_uc010vrl.1_Missense_Mutation_p.A744T|TRPV3_uc010vrm.1_RNA|TRPV3_uc002fvr.2_Missense_Mutation_p.A760T|TRPV3_uc002fvu.2_Missense_Mutation_p.G760S	NM_145068	NP_659505	Q8NET8	TRPV3_HUMAN	transient receptor potential cation channel,	760	Cytoplasmic (Potential).					integral to membrane	calcium channel activity			ovary(4)	4					Menthol(DB00825)	GCGACAGTACCTGTTCGTCTT	0.368			NA											25	13					0	0	0.00632	0	0
PELP1	27043	broad.mit.edu	37	17	4576947	4576947	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr17:4576947C>A	uc002fyi.3	-	14	1831	c.1605G>T	c.(1603-1605)ATG>ATT	p.M535I	PELP1_uc010vsf.1_Missense_Mutation_p.M388I	NM_014389	NP_055204	Q8IZL8	PELP1_HUMAN	proline, glutamic acid and leucine rich protein	535					transcription, DNA-dependent	cytoplasm|MLL1 complex	protein binding			ovary(1)|central_nervous_system(1)	2						GAGGCCCACACATGAGGATGG	0.502			NA											46	28					2.53126e-37	4.61273e-37	0.00361	1	0
AIPL1	23746	broad.mit.edu	37	17	6329034	6329034	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr17:6329034C>A	uc002gcp.2	-	6	996	c.901G>T	c.(901-903)GTG>TTG	p.V301L	AIPL1_uc002gcq.2_Missense_Mutation_p.V241L|AIPL1_uc002gcr.2_Missense_Mutation_p.V238L|AIPL1_uc010clk.2_Missense_Mutation_p.V279L|AIPL1_uc010cll.2_Missense_Mutation_p.V277L|AIPL1_uc002gcs.2_3'UTR	NM_014336	NP_055151	Q9NZN9	AIPL1_HUMAN	aryl hydrocarbon receptor interacting	301					protein farnesylation|protein folding|visual perception	cytoplasm|nucleus	farnesylated protein binding|unfolded protein binding				0				COAD - Colon adenocarcinoma(228;0.141)		TCCCTGCGCACCGCCTTCTGC	0.662			NA											22	25					2.41591e-17	3.89638e-17	0.004656	1	0
SLC13A5	284111	broad.mit.edu	37	17	6610444	6610444	+	Missense_Mutation	SNP	A	A	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr17:6610444A>T	uc002gdj.2	-	2	222	c.134T>A	c.(133-135)ATG>AAG	p.M45K	SLC13A5_uc010vtf.1_Missense_Mutation_p.M45K|SLC13A5_uc010clq.2_Intron|SLC13A5_uc002gdk.2_Missense_Mutation_p.M45K|SLC13A5_uc002gdl.1_5'Flank	NM_177550	NP_808218	Q86YT5	S13A5_HUMAN	solute carrier family 13, member 5 isoform a	45						integral to membrane	citrate transmembrane transporter activity				0						GTAAATGGCCATGAGGATGAT	0.567			NA											41	27					0	0	0.00361	0	0
FBXO39	162517	broad.mit.edu	37	17	6683462	6683462	+	Missense_Mutation	SNP	T	T	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr17:6683462T>A	uc010vtg.1	+	2	395	c.275T>A	c.(274-276)CTG>CAG	p.L92Q		NM_153230	NP_694962	Q8N4B4	FBX39_HUMAN	F-box protein 39	92										ovary(1)|skin(1)	2						CTGGAGCACCTGGAGGTCAAA	0.483			NA											101	53					0	0	0.00361	0	0
TP53	7157	broad.mit.edu	37	17	7578457	7578457	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr17:7578457C>G	uc002gim.2	-	5	667	c.473G>C	c.(472-474)CGC>CCC	p.R158P	TP53_uc002gig.1_Missense_Mutation_p.R158P|TP53_uc002gih.2_Missense_Mutation_p.R158P|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.R26P|TP53_uc010cng.1_Missense_Mutation_p.R26P|TP53_uc002gii.1_Missense_Mutation_p.R26P|TP53_uc010cnh.1_Missense_Mutation_p.R158P|TP53_uc010cni.1_Missense_Mutation_p.R158P|TP53_uc002gij.2_Missense_Mutation_p.R158P|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.R65P|TP53_uc002gio.2_Missense_Mutation_p.R26P|TP53_uc010vug.1_Missense_Mutation_p.R119P	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	158	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		R -> F (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|R -> H (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> C (in sporadic cancers; somatic mutation).|R -> P (in sporadic cancers; somatic mutation).|R -> S (in sporadic cancers; somatic mutation).|R -> Q (in a sporadic cancer; somatic mutation).|R -> G (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> L (in sporadic cancers; somatic mutation).|R -> Y (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R158H(58)|p.R158L(55)|p.R158C(17)|p.R158G(10)|p.R158P(9)|p.0?(7)|p.R158R(6)|p.R158fs*12(5)|p.R158_A159insX(4)|p.R158_A159delRA(2)|p.R156_I162delRVRAMAI(2)|p.V157fs*9(2)|p.P153fs*22(2)|p.R158fs*11(2)|p.V157fs*22(2)|p.V157_C176del20(1)|p.R156_A161delRVRAMA(1)|p.R158F(1)|p.P151_V173del23(1)|p.R158fs*24(1)|p.R65L(1)|p.R156_R158delRVR(1)|p.R156fs*18(1)|p.R156_A161del(1)|p.R158_A159insXX(1)|p.V157_M160delVRAM(1)|p.V157_R158delVR(1)|p.S149fs*72(1)|p.A159fs*21(1)|p.T155_A161delTRVRAMA(1)|p.G154fs*22(1)|p.R156fs*20(1)|p.V157_I162delVRAMAI(1)|p.R26L(1)|p.V157fs*21(1)|p.R158fs*8(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GGCCATGGCGCGGACGCGGGT	0.627	Pancreas(47;798 1329 9957 10801)		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumensyndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			54	30					0	0	0.00361	0	0
C17orf68	80169	broad.mit.edu	37	17	8140694	8140694	+	Missense_Mutation	SNP	T	T	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr17:8140694T>A	uc002gkq.3	-	5	850	c.791A>T	c.(790-792)CAG>CTG	p.Q264L	C17orf68_uc010cnv.2_RNA	NM_025099	NP_079375	Q2NKJ3	CTC1_HUMAN	alpha accessory factor 132	264					positive regulation of DNA replication|telomere maintenance	Stn1-Ten1 complex	protein binding|single-stranded DNA binding				0						AGTCCTCACCTGCACGATGAT	0.498			NA											58	37					0	0	0.00361	0	0
ARHGEF15	22899	broad.mit.edu	37	17	8222370	8222370	+	Silent	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr17:8222370C>A	uc002glc.2	+	13	2200	c.2079C>A	c.(2077-2079)GTC>GTA	p.V693V	ARHGEF15_uc002gld.2_Silent_p.V693V|ARHGEF15_uc010vuw.1_Silent_p.V582V	NM_173728	NP_776089	O94989	ARHGF_HUMAN	Rho guanine exchange factor 15	693					negative regulation of synapse maturation|regulation of Rho protein signal transduction	dendrite|intracellular	GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			ovary(2)|skin(1)	3						GCTCCCTGGTCCAGGCCCAGC	0.647			NA											60	30					2.2129e-31	3.94081e-31	0.00361	1	0
MYH10	4628	broad.mit.edu	37	17	8448782	8448782	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr17:8448782C>T	uc002gll.2	-	12	1481	c.1385G>A	c.(1384-1386)GGA>GAA	p.G462E	MYH10_uc002glm.2_Missense_Mutation_p.G472E|MYH10_uc010cnx.2_Missense_Mutation_p.G471E	NM_005964	NP_005955	P35580	MYH10_HUMAN	myosin, heavy polypeptide 10, non-muscle	462	Myosin head-like.				actin filament-based movement|axon guidance|cytokinesis after mitosis|regulation of cell shape	cell cortex|cleavage furrow|midbody|myosin complex|stress fiber	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(2)	2						AATTTCAAATCCAGCAATATC	0.353			NA											23	66					0	0	0.00278	0	0
MYH13	8735	broad.mit.edu	37	17	10233706	10233706	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr17:10233706C>A	uc002gmk.1	-	21	2523	c.2433G>T	c.(2431-2433)AGG>AGT	p.R811S		NM_003802	NP_003793	Q9UKX3	MYH13_HUMAN	myosin, heavy polypeptide 13, skeletal muscle	811	IQ.				muscle contraction	muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(4)|skin(2)	6						TGTGTCACCTCCTCTCCATCA	0.537			NA											24	12					7.63505e-26	1.33255e-25	0.002445	1	0
MYH8	4626	broad.mit.edu	37	17	10302883	10302883	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr17:10302883C>A	uc002gmm.2	-	28	3934	c.3839G>T	c.(3838-3840)AGA>ATA	p.R1280I	uc002gml.1_Intron	NM_002472	NP_002463	P13535	MYH8_HUMAN	myosin, heavy chain 8, skeletal muscle,	1280	Potential.				muscle filament sliding	cytosol|muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			skin(6)|ovary(3)|breast(2)	11						CAGGCGCGCTCTCTGTGCTGT	0.468			NA							Trismus-Pseudocamptodactyly_Syndrome_with_Cardiac_Myxoma_and_Freckling				13	138					6.81908e-15	1.0486e-14	0.00245	1	0
MYH4	4622	broad.mit.edu	37	17	10357003	10357003	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr17:10357003G>A	uc002gmn.2	-	23	3002	c.2891C>T	c.(2890-2892)ACA>ATA	p.T964I	uc002gml.1_Intron	NM_017533	NP_060003	Q9Y623	MYH4_HUMAN	myosin, heavy polypeptide 4, skeletal muscle	964	Potential.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(10)|skin(2)|central_nervous_system(1)	13						CTTGGCCAGTGTCAGCTCAAG	0.413			NA											38	277					0	0	0.009718	0	0
MYH2	4620	broad.mit.edu	37	17	10429960	10429960	+	Nonsense_Mutation	SNP	G	G	T	rs1042076	byFrequency	TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr17:10429960G>T	uc010coi.2	-	30	4271	c.4143C>A	c.(4141-4143)TAC>TAA	p.Y1381*	uc002gml.1_Intron|MYH2_uc002gmp.3_Nonsense_Mutation_p.Y1381*|MYH2_uc010coj.2_Intron	NM_001100112	NP_001093582	Q9UKX2	MYH2_HUMAN	myosin heavy chain IIa	1381	Potential.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(5)|pancreas(4)|skin(3)|lung(1)|kidney(1)	14						CGTCCGTCTCGTATTTGGTCC	0.532			NA											16	210					1.40151e-16	2.2385e-16	0.010504	1	0
ZNF287	57336	broad.mit.edu	37	17	16455682	16455682	+	Missense_Mutation	SNP	A	A	G			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr17:16455682A>G	uc002gqi.2	-	6	2227	c.1774T>C	c.(1774-1776)TAT>CAT	p.Y592H		NM_020653	NP_065704	Q9HBT7	ZN287_HUMAN	zinc finger protein 287	585	C2H2-type 9.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0				UCEC - Uterine corpus endometrioid carcinoma (92;0.083)		TTACATATATAGGATTTCTCT	0.378			NA											35	41					0	0	0.00874	0	0
ZNF287	57336	broad.mit.edu	37	17	16466476	16466476	+	Missense_Mutation	SNP	T	T	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr17:16466476T>A	uc002gqi.2	-	5	1152	c.699A>T	c.(697-699)TTA>TTT	p.L233F		NM_020653	NP_065704	Q9HBT7	ZN287_HUMAN	zinc finger protein 287	226	KRAB.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0				UCEC - Uterine corpus endometrioid carcinoma (92;0.083)		TAGGGCCTTCTAAAATTTCTT	0.358			NA											31	21					0	0	0.004878	0	0
SMCR8	140775	broad.mit.edu	37	17	18220322	18220322	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr17:18220322C>T	uc002gsy.3	+	1	1729	c.1219C>T	c.(1219-1221)CCA>TCA	p.P407S		NM_144775	NP_658988	Q8TEV9	SMCR8_HUMAN	Smith-Magenis syndrome chromosome region,	407										central_nervous_system(1)	1						AGAAGAATGCCCAATTCCTAA	0.468			NA											13	37					0	0	0.00245	0	0
LGALS9C	654346	broad.mit.edu	37	17	18392294	18392294	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr17:18392294G>A	uc002gtw.2	+	5	554	c.484G>A	c.(484-486)GTG>ATG	p.V162M	LGALS9C_uc010vyb.1_Missense_Mutation_p.V74M	NM_001040078	NP_001035167	Q6DKI2	LEG9C_HUMAN	galectin 9 like	162							sugar binding			ovary(1)	1						CTTCTCCACGGTGCCGTTCTC	0.597			NA											4	67					0	0	0.000602	0	0
MAP2K3	5606	broad.mit.edu	37	17	21207773	21207773	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr17:21207773G>T	uc002gys.2	+	8	869	c.604G>T	c.(604-606)GGC>TGC	p.G202C	MAP2K3_uc002gyt.2_Missense_Mutation_p.G173C|MAP2K3_uc002gyu.2_Missense_Mutation_p.G173C	NM_145109	NP_659731	P46734	MP2K3_HUMAN	mitogen-activated protein kinase kinase 3	202	Protein kinase.				activation of MAPK activity|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of transcription, DNA-dependent|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|MAP kinase kinase activity|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity				0				COAD - Colon adenocarcinoma(3;0.0131)|Colorectal(15;0.0553)		CAACAAGGAGGGCCATGTGAA	0.577			NA											26	95					2.41591e-17	3.89638e-17	0.004656	1	0
KCNJ12	3768	broad.mit.edu	37	17	21318894	21318894	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr17:21318894G>T	uc002gyv.1	+	3	945	c.240G>T	c.(238-240)TGG>TGT	p.W80C		NM_021012	NP_066292	Q14500	IRK12_HUMAN	potassium inwardly-rectifying channel, subfamily	80	Cytoplasmic (By similarity).				blood circulation|muscle contraction|regulation of heart contraction|synaptic transmission	integral to membrane	inward rectifier potassium channel activity|ion channel inhibitor activity|potassium channel regulator activity			ovary(3)|skin(1)	4				Colorectal(15;0.0183)|COAD - Colon adenocarcinoma(3;0.0732)	Dofetilide(DB00204)	ACATCCGCTGGCGGTACATGC	0.572			NA								Prostate(3;0.18)			13	73					3.70931e-20	6.14911e-20	0.006122	1	0
TIAF1	9220	broad.mit.edu	37	17	27401991	27401991	+	Translation_Start_Site	SNP	C	C	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr17:27401991C>T	uc002hdv.1	-	1	637	c.-773G>A	c.(-775--771)GCGTG>GCATG		MYO18A_uc010wbc.1_Intron|MYO18A_uc002hds.2_Intron|MYO18A_uc010csa.1_Intron|MYO18A_uc002hdt.1_Intron|MYO18A_uc002hdu.1_Intron	NM_004740	NP_004731	O95411	TIAF1_HUMAN	TGFB1-induced anti-apoptotic factor 1						anti-apoptosis|apoptosis|I-kappaB kinase/NF-kappaB cascade	nucleus					0	Lung NSC(42;0.015)		Epithelial(11;1.19e-05)|all cancers(11;6.57e-05)|BRCA - Breast invasive adenocarcinoma(11;0.000153)|Colorectal(6;0.0102)|COAD - Colon adenocarcinoma(6;0.031)			TAAGCACGCACGCCTTTGGTT	0.507			NA											6	23					0	0	0.001168	0	0
SSH2	85464	broad.mit.edu	37	17	27958224	27958225	+	Nonsense_Mutation	DNP	CC	CC	AA			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr17:27958224_27958225CC>AA	uc002heo.1	-	15	3906_3907	c.3906_3907GG>TT	c.(3904-3909)ATGGAG>ATTTAG	p.1302_1303ME>I*	SSH2_uc010wbh.1_Nonsense_Mutation_p.1329_1330ME>I*	NM_033389	NP_203747	Q76I76	SSH2_HUMAN	slingshot 2	1302_1303					actin cytoskeleton organization|regulation of actin polymerization or depolymerization|regulation of axonogenesis|regulation of lamellipodium assembly	cytoplasm|cytoskeleton	actin binding|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			skin(2)	2						TCTTGGTCCTCCATCGCGTGCA	0.525			NA											15	55					0	0	0.004672	0	0
CCDC55	84081	broad.mit.edu	37	17	28506291	28506291	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr17:28506291G>C	uc002heu.2	+	5	512	c.484G>C	c.(484-486)GAA>CAA	p.E162Q	CCDC55_uc002hev.2_Missense_Mutation_p.E108Q|CCDC55_uc010wbl.1_Missense_Mutation_p.E108Q|CCDC55_uc010wbm.1_Missense_Mutation_p.E108Q|CCDC55_uc002hex.2_Missense_Mutation_p.E108Q	NM_032141	NP_115517	Q9H0G5	NSRP1_HUMAN	coiled-coil domain containing 55 isoform 1	162	Necessary for alternative splicing activity.|Potential.				developmental process|nucleocytoplasmic transport|regulation of alternative nuclear mRNA splicing, via spliceosome	nuclear speck|ribonucleoprotein complex	mRNA binding|protein binding				0						AGAAGAAAGAGAAAAGAGGGC	0.428			NA											12	15					0	0	0.001855	0	0
ATAD5	79915	broad.mit.edu	37	17	29171879	29171879	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr17:29171879C>G	uc002hfs.1	+	6	2741	c.2395C>G	c.(2395-2397)CTT>GTT	p.L799V	ATAD5_uc002hft.1_Missense_Mutation_p.L696V	NM_024857	NP_079133	Q96QE3	ATAD5_HUMAN	ATPase family, AAA domain containing 5	799					response to DNA damage stimulus	nucleus	ATP binding|nucleoside-triphosphatase activity			ovary(3)	3		all_hematologic(16;0.0202)|Acute lymphoblastic leukemia(14;0.0238)|Myeloproliferative disorder(56;0.0393)				TCCTTTATTTCTTGTCAGAAA	0.308			NA											21	62					0	0	0.00632	0	0
NF1	4763	broad.mit.edu	37	17	29677323	29677323	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr17:29677323G>A	uc002hgg.2	+	50	7777	c.7444G>A	c.(7444-7446)GAC>AAC	p.D2482N	NF1_uc002hgh.2_Missense_Mutation_p.D2461N|NF1_uc010cso.2_Missense_Mutation_p.D670N|NF1_uc010wbt.1_Silent_p.V12V|NF1_uc010wbu.1_RNA	NM_001042492	NP_001035957	P21359	NF1_HUMAN	neurofibromin isoform 1	2482					actin cytoskeleton organization|adrenal gland development|artery morphogenesis|camera-type eye morphogenesis|cerebral cortex development|collagen fibril organization|forebrain astrocyte development|forebrain morphogenesis|heart development|liver development|MAPKKK cascade|metanephros development|myelination in peripheral nervous system|negative regulation of cell migration|negative regulation of endothelial cell proliferation|negative regulation of MAP kinase activity|negative regulation of MAPKKK cascade|negative regulation of neuroblast proliferation|negative regulation of oligodendrocyte differentiation|negative regulation of transcription factor import into nucleus|osteoblast differentiation|phosphatidylinositol 3-kinase cascade|pigmentation|positive regulation of adenylate cyclase activity|positive regulation of neuron apoptosis|Ras protein signal transduction|regulation of blood vessel endothelial cell migration|regulation of bone resorption|response to hypoxia|smooth muscle tissue development|spinal cord development|sympathetic nervous system development|visual learning|wound healing	axon|cytoplasm|dendrite|intrinsic to internal side of plasma membrane|nucleus	protein binding|Ras GTPase activator activity			soft_tissue(159)|central_nervous_system(56)|lung(28)|large_intestine(27)|haematopoietic_and_lymphoid_tissue(18)|ovary(18)|autonomic_ganglia(12)|breast(3)|skin(3)|stomach(2)|thyroid(1)|prostate(1)|kidney(1)|pancreas(1)	330		all_cancers(10;1.29e-12)|all_epithelial(10;0.00347)|all_hematologic(16;0.00556)|Acute lymphoblastic leukemia(14;0.00593)|Breast(31;0.014)|Myeloproliferative disorder(56;0.0255)|all_lung(9;0.0321)|Lung NSC(157;0.0659)		UCEC - Uterine corpus endometrioid carcinoma (4;4.38e-05)|all cancers(4;1.64e-26)|Epithelial(4;9.15e-23)|OV - Ovarian serous cystadenocarcinoma(4;3.58e-21)|GBM - Glioblastoma multiforme(4;0.00146)		TCATCATGGTGACCCTTCCTA	0.363			NA	D|Mis|N|F|S|O		neurofibroma|glioma	neurofibroma|glioma			Neurofibromatosis_type_1	TCGA GBM(6;<1E-08)|TSP Lung(7;0.0071)|TCGA Ovarian(3;0.0088)			14	57					0	0	0.003163	0	0
RFFL	117584	broad.mit.edu	37	17	33348688	33348688	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr17:33348688C>A	uc002hin.1	-	3	466	c.293G>T	c.(292-294)CGA>CTA	p.R98L	RFFL_uc002hiq.2_Intron|RFFL_uc002him.1_Missense_Mutation_p.R98L|RFFL_uc010cti.1_Missense_Mutation_p.R104L|RFFL_uc002hip.1_Missense_Mutation_p.R98L|RFFL_uc002hio.1_Missense_Mutation_p.R98L	NM_001017368	NP_001017368	Q8WZ73	RFFL_HUMAN	rififylin	98					apoptosis	membrane	ligase activity|zinc ion binding				0		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0227)		GAGCTCCTCTCGCTGAAAGGC	0.517			NA											35	42					4.32679e-17	6.9481e-17	0.006999	1	0
FNDC8	54752	broad.mit.edu	37	17	33454165	33454165	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr17:33454165C>A	uc002hix.2	+	2	396	c.314C>A	c.(313-315)CCC>CAC	p.P105H		NM_017559	NP_060029	Q8TC99	FNDC8_HUMAN	fibronectin type III domain containing 8	105										ovary(2)	2		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.022)		GTGACCCAGCCCAACAGCAGC	0.552			NA											67	119					1.25089e-41	2.29638e-41	0.00361	1	0
CCL14	6358	broad.mit.edu	37	17	34311469	34311469	+	Silent	SNP	T	T	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr17:34311469T>A	uc010wcr.1	-	2	178	c.99A>T	c.(97-99)TCA>TCT	p.S33S	CCL16_uc002hkl.2_5'Flank|CCL16_uc002hkm.2_5'Flank|CCL14_uc010wcq.1_Silent_p.S49S|CCL14_uc002hkn.2_RNA|CCL14-CCL15_uc010wcs.1_RNA|CCL14-CCL15_uc010wct.1_RNA|uc002hkq.2_5'Flank	NM_032963	NP_116739	Q16627	CCL14_HUMAN	chemokine (C-C motif) ligand 14 isoform 1	33					cellular calcium ion homeostasis|immune response|positive regulation of cell proliferation	extracellular space	chemokine activity|signal transducer activity				0		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		AGCAGCACTCTGAGGGGTGGT	0.552			NA											19	39					0	0	0.010504	0	0
PLXDC1	57125	broad.mit.edu	37	17	37234203	37234203	+	Silent	SNP	G	G	C			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr17:37234203G>C	uc002hrg.2	-	11	1361	c.1149C>G	c.(1147-1149)ACC>ACG	p.T383T	uc002hre.1_Intron|uc002hrf.1_Intron|PLXDC1_uc010cvr.1_Silent_p.T91T|PLXDC1_uc002hrh.2_RNA|PLXDC1_uc002hri.2_RNA|PLXDC1_uc002hrj.1_RNA|PLXDC1_uc002hrk.1_RNA	NM_020405	NP_065138	Q8IUK5	PXDC1_HUMAN	plexin domain containing 1 precursor	383	Extracellular (Potential).				angiogenesis	cytoplasm|extracellular region|integral to membrane|tight junction				ovary(1)|kidney(1)|skin(1)	3						GGGAGGAGGAGGTAGTGGTGA	0.597			NA											21	94					0	0	0.003954	0	0
TOP2A	7153	broad.mit.edu	37	17	38556818	38556818	+	Missense_Mutation	SNP	A	A	G			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr17:38556818A>G	uc002huq.2	-	22	2888	c.2762T>C	c.(2761-2763)ATT>ACT	p.I921T		NM_001067	NP_001058	P11388	TOP2A_HUMAN	DNA topoisomerase II, alpha isozyme	921					apoptotic chromosome condensation|DNA ligation|DNA repair|DNA topological change|DNA-dependent DNA replication|mitotic cell cycle G2/M transition decatenation checkpoint|mitotic recombination|phosphatidylinositol-mediated signaling|positive regulation of apoptosis|positive regulation of retroviral genome replication|resolution of meiotic recombination intermediates|sister chromatid segregation	cytoplasm|DNA topoisomerase complex (ATP-hydrolyzing)|nucleolus|nucleoplasm|synaptonemal complex	ATP binding|chromatin binding|DNA topoisomerase (ATP-hydrolyzing) activity|DNA-dependent ATPase activity|drug binding|histone deacetylase binding|protein C-terminus binding|protein heterodimerization activity|protein homodimerization activity|protein kinase C binding|sequence-specific DNA binding transcription factor activity|ubiquitin binding			ovary(4)|large_intestine(1)|central_nervous_system(1)|skin(1)	7		Breast(137;0.00328)	STAD - Stomach adenocarcinoma(5;0.00183)		Amsacrine(DB00276)|Ciprofloxacin(DB00537)|Dexrazoxane(DB00380)|Doxorubicin(DB00997)|Enoxacin(DB00467)|Epirubicin(DB00445)|Etoposide(DB00773)|Fleroxacin(DB04576)|Gatifloxacin(DB01044)|Idarubicin(DB01177)|Levofloxacin(DB01137)|Lomefloxacin(DB00978)|Lucanthone(DB04967)|Mitoxantrone(DB01204)|Moxifloxacin(DB00218)|Norfloxacin(DB01059)|Ofloxacin(DB01165)|Pefloxacin(DB00487)|Podofilox(DB01179)|Sparfloxacin(DB01208)|Teniposide(DB00444)|Trovafloxacin(DB00685)|Valrubicin(DB00385)	TGAGATTTCAATGGTTGTAGA	0.353			NA											8	11					0	0	0.006214	0	0
KRT31	3881	broad.mit.edu	37	17	39551870	39551870	+	Silent	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr17:39551870G>T	uc002hwn.2	-	4	647	c.594C>A	c.(592-594)GTC>GTA	p.V198V	KRT31_uc010cxn.2_Silent_p.V198V	NM_002277	NP_002268	Q15323	K1H1_HUMAN	keratin 31	198	Rod.|Coil 1B.				epidermis development	intermediate filament	protein binding|structural constituent of cytoskeleton				0		Breast(137;0.000496)				GCAGGGTATTGACCTCCTATG	0.488			NA											5	46					0.000157383	0.000177026	0.00308	1	0
KRT38	8687	broad.mit.edu	37	17	39595035	39595035	+	Missense_Mutation	SNP	T	T	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr17:39595035T>A	uc002hwq.1	-	4	1231	c.808A>T	c.(808-810)AAC>TAC	p.N270Y		NM_006771	NP_006762	O76015	KRT38_HUMAN	keratin 38	270	Coil 2.|Rod.					intermediate filament	structural molecule activity			skin(2)	2		Breast(137;0.000496)				AGCACCCTGTTCAGGTCAATG	0.587			NA											38	206					0	0	0.002522	0	0
KRT36	8689	broad.mit.edu	37	17	39646024	39646024	+	Silent	SNP	G	G	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr17:39646024G>A	uc002hwt.2	-	1	93	c.93C>T	c.(91-93)ATC>ATT	p.I31I		NM_003771	NP_003762	O76013	KRT36_HUMAN	keratin 36	31	Head.					intermediate filament	protein binding|structural constituent of epidermis				0		Breast(137;0.000286)				CCACAGAACGGATGGAGGACA	0.637			NA											12	62					0	0	0.00245	0	0
KRT17	3872	broad.mit.edu	37	17	39780443	39780443	+	Missense_Mutation	SNP	C	C	T	rs150004075	byFrequency	TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr17:39780443C>T	uc002hxh.2	-	1	440	c.319G>A	c.(319-321)GAG>AAG	p.E107K	JUP_uc010wfs.1_Intron|KRT17_uc010wft.1_Missense_Mutation_p.E107K	NM_000422	NP_000413	Q04695	K1C17_HUMAN	keratin 17	107	Coil 1A.|Peptide epitope S1; induces T-cell and keratinocyte proliferation and IFN-gamma production.|Rod.			Missing (in Ref. 5; AAH72018).	epidermis development	cytoplasm|intermediate filament	protein binding|structural constituent of cytoskeleton			ovary(1)|skin(1)	2		Breast(137;0.000307)				GTGTTGGCCTCCTCCAGGGCA	0.622	Pancreas(92;1242 2086 39193 50508)		NA							Steatocystoma_Multiplex				32	243					0	0	0.004289	0	0
FKBP10	60681	broad.mit.edu	37	17	39975577	39975577	+	Silent	SNP	C	C	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr17:39975577C>T	uc002hxv.2	+	5	1168	c.843C>T	c.(841-843)CGC>CGT	p.R281R	FKBP10_uc002hxw.1_5'UTR	NM_021939	NP_068758	Q96AY3	FKB10_HUMAN	FK506 binding protein 10 precursor	281					protein folding	endoplasmic reticulum lumen|membrane	calcium ion binding|FK506 binding|peptidyl-prolyl cis-trans isomerase activity			ovary(1)	1		Breast(137;0.00122)		BRCA - Breast invasive adenocarcinoma(366;0.148)		GCTGTGTCCGCAGAGCCGGGG	0.632			NA											32	79					0	0	0.003755	0	0
GHDC	84514	broad.mit.edu	37	17	40344963	40344963	+	Silent	SNP	G	G	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr17:40344963G>A	uc002hzd.2	-	3	832	c.348C>T	c.(346-348)CCC>CCT	p.P116P	GHDC_uc002hzg.1_Silent_p.P116P|GHDC_uc010wgg.1_Intron|GHDC_uc002hze.3_Silent_p.P116P|GHDC_uc002hzf.3_Silent_p.P116P|GHDC_uc010cxz.2_RNA	NM_032484	NP_115873	Q8N2G8	GHDC_HUMAN	LGP1 homolog isoform 1	116						endoplasmic reticulum|nuclear envelope					0		all_cancers(22;0.000229)|Breast(137;0.00104)|all_epithelial(22;0.00304)		BRCA - Breast invasive adenocarcinoma(366;0.124)		TTGAGGTCGGGGGCAGTGGCT	0.592			NA											39	111					0	0	0.006999	0	0
PLEKHH3	79990	broad.mit.edu	37	17	40823471	40823471	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr17:40823471C>G	uc002iau.2	-	8	1649	c.1182G>C	c.(1180-1182)GAG>GAC	p.E394D	PLEKHH3_uc010cyl.1_RNA|PLEKHH3_uc002iat.1_RNA|PLEKHH3_uc002iav.2_RNA|PLEKHH3_uc010cym.1_Intron|PLEKHH3_uc002iaw.2_Missense_Mutation_p.E394D	NM_024927	NP_079203	Q7Z736	PKHH3_HUMAN	pleckstrin homology domain containing, family H	394	MyTH4.				signal transduction	cytoskeleton				large_intestine(1)|ovary(1)	2		Breast(137;0.00116)		BRCA - Breast invasive adenocarcinoma(366;0.14)		ACGCGGAAATCTCCGCCAGCG	0.682			NA											12	20					0	0	0.001855	0	0
RAMP2	10266	broad.mit.edu	37	17	40914379	40914379	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr17:40914379C>A	uc002ibg.2	+	3	238	c.170C>A	c.(169-171)ACG>AAG	p.T57K	LOC100190938_uc002ibd.1_5'Flank|LOC100190938_uc002ibe.3_5'Flank|LOC100190938_uc002ibf.3_5'Flank|RAMP2_uc010cyt.2_Missense_Mutation_p.T62K|RAMP2_uc002ibh.2_Intron	NM_005854	NP_005845	O60895	RAMP2_HUMAN	receptor activity modifying protein 2 precursor	57	Extracellular (Potential).				intracellular protein transport|receptor-mediated endocytosis|regulation of G-protein coupled receptor protein signaling pathway	coated pit|integral to plasma membrane|lysosome	protein transporter activity				0		Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.0741)	Pramlintide(DB01278)	ACAGGGGGGACGGTGAAGAAC	0.498			NA											74	124					4.00701e-44	7.38343e-44	0.00361	1	0
MPP2	4355	broad.mit.edu	37	17	41958884	41958884	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr17:41958884C>T	uc010wip.1	-	7	947	c.890G>A	c.(889-891)CGC>CAC	p.R297H	MPP2_uc002ien.1_Missense_Mutation_p.R269H|MPP2_uc010wim.1_Missense_Mutation_p.R241H|MPP2_uc002ieo.1_Missense_Mutation_p.R252H|MPP2_uc010win.1_Missense_Mutation_p.R113H|MPP2_uc010wio.1_Missense_Mutation_p.R241H	NM_005374	NP_005365	Q14168	MPP2_HUMAN	palmitoylated membrane protein 2	276	SH3.				signal transduction	cell surface|integral to plasma membrane|membrane fraction	guanylate kinase activity				0		Breast(137;0.00314)		BRCA - Breast invasive adenocarcinoma(366;0.12)		GGCGTTGAAGCGCAGGCCTGC	0.587			NA											50	61					0	0	0.00361	0	0
GRN	2896	broad.mit.edu	37	17	42429545	42429545	+	Missense_Mutation	SNP	A	A	G			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr17:42429545A>G	uc002igp.1	+	11	1561	c.1342A>G	c.(1342-1344)ACC>GCC	p.T448A	GRN_uc002igr.1_Missense_Mutation_p.T242A	NM_002087	NP_002078	P28799	GRN_HUMAN	granulin precursor	448					signal transduction	extracellular space	cytokine activity|growth factor activity			ovary(2)|central_nervous_system(2)|skin(1)	5		Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.189)		TGACCAGCACACCAGCTGCCC	0.667			NA											24	113					0	0	0.007291	0	0
GPATCH8	23131	broad.mit.edu	37	17	42475031	42475031	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr17:42475031C>G	uc002igw.1	-	8	4478	c.4414G>C	c.(4414-4416)GCT>CCT	p.A1472P	GPATCH8_uc002igv.1_Missense_Mutation_p.A1394P|GPATCH8_uc010wiz.1_Missense_Mutation_p.A1394P	NM_001002909	NP_001002909	Q9UKJ3	GPTC8_HUMAN	G patch domain containing 8	1472	Poly-Ala.					intracellular	nucleic acid binding|zinc ion binding			ovary(2)|kidney(1)|skin(1)	4		Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.206)		GCTGCTGCAGCAGGCCGTGGA	0.602			NA											6	43					0	0	0.001984	0	0
HOXB5	3215	broad.mit.edu	37	17	46669576	46669576	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr17:46669576G>C	uc002inr.2	-	2	864	c.805C>G	c.(805-807)CCC>GCC	p.P269A	HOXB3_uc010wlm.1_5'Flank|HOXB3_uc010dbf.2_5'Flank|HOXB3_uc010dbg.2_5'Flank	NM_002147	NP_002138	P09067	HXB5_HUMAN	homeobox B5	269						nucleus	sequence-specific DNA binding				0						CGGGCTCAGGGCTGGAAGGCG	0.657			NA											15	50					0	0	0.004007	0	0
TTLL6	284076	broad.mit.edu	37	17	46868950	46868950	+	Silent	SNP	G	G	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr17:46868950G>A	uc010wlo.1	-	10	1049	c.1014C>T	c.(1012-1014)TTC>TTT	p.F338F	TTLL6_uc002iob.2_Silent_p.F31F|TTLL6_uc010dbi.2_RNA|TTLL6_uc002ioc.2_Silent_p.F91F|TTLL6_uc002iod.2_Silent_p.F185F	NM_001130918	NP_001124390	Q8N841	TTLL6_HUMAN	tubulin tyrosine ligase-like family, member 6	290	TTL.					cilium|microtubule basal body	ATP binding|tubulin binding|tubulin-tyrosine ligase activity				0						AGTATGCACTGAAGGTGGAGA	0.557			NA									OREG0024526	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	26	41					0	0	0.007291	0	0
COL1A1	1277	broad.mit.edu	37	17	48275559	48275559	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr17:48275559G>C	uc002iqm.2	-	7	677	c.551C>G	c.(550-552)TCT>TGT	p.S184C		NM_000088	NP_000079	P02452	CO1A1_HUMAN	alpha 1 type I collagen preproprotein	184	Triple-helical region.				axon guidance|blood vessel development|collagen biosynthetic process|collagen fibril organization|embryonic skeletal system development|leukocyte migration|platelet activation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell migration|positive regulation of epithelial to mesenchymal transition|positive regulation of transcription, DNA-dependent|protein localization to nucleus|sensory perception of sound|skin morphogenesis|tooth mineralization|visual perception	collagen type I|extracellular space|plasma membrane	identical protein binding|platelet-derived growth factor binding		COL1A1/PDGFB(372)	soft_tissue(372)|central_nervous_system(7)|skin(1)|breast(1)|pancreas(1)	382					Collagenase(DB00048)|Palifermin(DB00039)	ACGAGGACCAGAGGGACCCTA	0.562			NA	T	PDGFB|USP6	dermatofibrosarcoma protuberans|aneurysmal bone cyst 		Osteogenesis imperfecta				OREG0024560	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	45	47					0	0	0.00361	0	0
CACNA1G	8913	broad.mit.edu	37	17	48655862	48655862	+	Silent	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr17:48655862C>A	uc002irk.1	+	9	2610	c.2238C>A	c.(2236-2238)GGC>GGA	p.G746G	CACNA1G_uc002iri.1_Silent_p.G746G|CACNA1G_uc002irj.1_Silent_p.G746G|CACNA1G_uc002irl.1_Silent_p.G746G|CACNA1G_uc002irm.1_Silent_p.G746G|CACNA1G_uc002irn.1_Silent_p.G746G|CACNA1G_uc002iro.1_Silent_p.G746G|CACNA1G_uc002irp.1_Silent_p.G746G|CACNA1G_uc002irq.1_Silent_p.G746G|CACNA1G_uc002irr.1_Silent_p.G746G|CACNA1G_uc002irs.1_Silent_p.G746G|CACNA1G_uc002irt.1_Silent_p.G746G|CACNA1G_uc002irv.1_Silent_p.G746G|CACNA1G_uc002irw.1_Silent_p.G746G|CACNA1G_uc002iru.1_Silent_p.G746G|CACNA1G_uc002irx.1_Silent_p.G659G|CACNA1G_uc002iry.1_Silent_p.G659G|CACNA1G_uc002irz.1_Silent_p.G659G|CACNA1G_uc002isa.1_Silent_p.G659G|CACNA1G_uc002isb.1_Silent_p.G659G|CACNA1G_uc002isc.1_Silent_p.G659G|CACNA1G_uc002isd.1_Silent_p.G659G|CACNA1G_uc002ise.1_Silent_p.G659G|CACNA1G_uc002isf.1_Silent_p.G659G|CACNA1G_uc002isg.1_Silent_p.G659G|CACNA1G_uc002ish.1_Silent_p.G659G|CACNA1G_uc002isi.1_Silent_p.G659G	NM_018896	NP_061496	O43497	CAC1G_HUMAN	voltage-dependent calcium channel alpha 1G	746	Helical; Name=S1 of repeat II; (Potential).|II.				axon guidance	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(1)	1	Breast(11;6.7e-17)		BRCA - Breast invasive adenocarcinoma(22;7.52e-09)		Ethosuximide(DB00593)|Flunarizine(DB04841)|Levetiracetam(DB01202)|Mibefradil(DB01388)|Pimozide(DB01100)|Trimethadione(DB00347)|Verapamil(DB00661)|Zonisamide(DB00909)	AGTACTTTGGCCGGGGAATCA	0.582			NA											34	50					4.92203e-23	8.4127e-23	0.00623	1	0
AKAP1	8165	broad.mit.edu	37	17	55193519	55193519	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr17:55193519G>T	uc002iux.2	+	7	2560	c.2329G>T	c.(2329-2331)GCC>TCC	p.A777S	AKAP1_uc010wnl.1_Missense_Mutation_p.A777S|AKAP1_uc010dcm.2_Missense_Mutation_p.A777S	NM_003488	NP_003479	Q92667	AKAP1_HUMAN	A-kinase anchor protein 1 precursor	777	Tudor.				blood coagulation	cytosol|integral to membrane|mitochondrial outer membrane	protein binding|RNA binding			ovary(1)	1	Breast(9;5.46e-08)					CTGGTGGCGAGCCCAAGTGGT	0.617			NA											14	47					1.37285e-15	2.15568e-15	0.004007	1	0
MPO	4353	broad.mit.edu	37	17	56355235	56355235	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr17:56355235G>C	uc002ivu.1	-	7	1334	c.1157C>G	c.(1156-1158)CCC>CGC	p.P386R		NM_000250	NP_000241	P05164	PERM_HUMAN	myeloperoxidase	386					anti-apoptosis|hydrogen peroxide catabolic process|low-density lipoprotein particle remodeling	extracellular space|lysosome|nucleus|stored secretory granule	chromatin binding|heme binding|heparin binding|peroxidase activity			ovary(2)|large_intestine(1)|pancreas(1)	4					Cefdinir(DB00535)	GAGGAGACAGGGGTCATCGTG	0.632			NA											38	56					0	0	0.003214	0	0
SEPT4	5414	broad.mit.edu	37	17	56599366	56599366	+	Silent	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr17:56599366C>A	uc002iwm.1	-	6	887	c.759G>T	c.(757-759)GTG>GTT	p.V253V	SEPT4_uc002iwk.1_Silent_p.V106V|SEPT4_uc010wnw.1_Silent_p.V106V|SEPT4_uc002iwl.1_Silent_p.V106V|SEPT4_uc002iwn.1_Silent_p.V154V|SEPT4_uc002iwo.1_Silent_p.V234V|SEPT4_uc002iwp.1_Silent_p.V234V|SEPT4_uc010wnx.1_Silent_p.V268V|SEPT4_uc010wny.1_Silent_p.V245V|SEPT4_uc010dcy.1_Silent_p.V135V	NM_004574	NP_004565	O43236	SEPT4_HUMAN	septin 4 isoform 1	253					apoptosis|cell cycle|cytokinesis|regulation of apoptosis	cytoskeleton|mitochondrion|nucleus	GTP binding|GTPase activity|protein binding|structural molecule activity				0	Medulloblastoma(34;0.127)|all_neural(34;0.237)					GGCAGCAGTGCACCCTGTTGT	0.557			NA											38	59					6.68952e-21	1.12146e-20	0.003214	1	0
TRIM37	4591	broad.mit.edu	37	17	57157191	57157191	+	Silent	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr17:57157191C>A	uc002iwy.3	-	7	984	c.540G>T	c.(538-540)CGG>CGT	p.R180R	TRIM37_uc002iwz.3_Silent_p.R180R|TRIM37_uc002ixa.3_Silent_p.R58R|TRIM37_uc010woc.1_Silent_p.R146R	NM_001005207	NP_001005207	O94972	TRI37_HUMAN	tripartite motif-containing 37 protein	180	Potential.					perinuclear region of cytoplasm|peroxisome	ligase activity|protein binding|zinc ion binding			lung(2)|pancreas(2)|ovary(1)|skin(1)|breast(1)	7	Medulloblastoma(34;0.0922)|all_neural(34;0.101)					TCCTAATTTCCCGAACACGCT	0.363			NA							Mulibrey_Nanism				29	99					2.08457e-15	3.25604e-15	0.002096	1	0
EFCAB3	146779	broad.mit.edu	37	17	60472491	60472491	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr17:60472491C>A	uc002izu.1	+	6	508	c.430C>A	c.(430-432)CTA>ATA	p.L144I	EFCAB3_uc010wpc.1_Missense_Mutation_p.L196I	NM_173503	NP_775774	Q8N7B9	EFCB3_HUMAN	EF-hand calcium binding domain 3 isoform b	144							calcium ion binding			skin(1)	1			BRCA - Breast invasive adenocarcinoma(2;2.27e-11)			GTTTGAAATCCTATCAAGGCT	0.393			NA											19	89					1.96895e-08	2.58414e-08	0.00278	1	0
TANC2	26115	broad.mit.edu	37	17	61417549	61417549	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr17:61417549C>T	uc002jal.3	+	10	1464	c.1441C>T	c.(1441-1443)CGC>TGC	p.R481C	TANC2_uc010wpe.1_Missense_Mutation_p.R391C	NM_025185	NP_079461	Q9HCD6	TANC2_HUMAN	tetratricopeptide repeat, ankyrin repeat and	481							binding			ovary(2)	2						CTTGCTCTGCCGCTCACCTCA	0.527			NA											48	39					0	0	0.00361	0	0
KCNH6	81033	broad.mit.edu	37	17	61607486	61607486	+	Silent	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr17:61607486C>A	uc002jay.2	+	3	422	c.342C>A	c.(340-342)CCC>CCA	p.P114P	KCNH6_uc002jax.1_Silent_p.P114P|KCNH6_uc010wpl.1_5'UTR|KCNH6_uc010wpm.1_Silent_p.P114P|KCNH6_uc002jaz.1_Silent_p.P114P	NM_030779	NP_110406	Q9H252	KCNH6_HUMAN	potassium voltage-gated channel, subfamily H,	114	PAC.|Cytoplasmic (Potential).				regulation of transcription, DNA-dependent|signal transduction					skin(1)	1					Ibutilide(DB00308)	ATGTGGTGCCCGTGAAGAACG	0.642			NA											17	92					1.15919e-05	1.35939e-05	0.008871	1	0
GH1	2688	broad.mit.edu	37	17	61994765	61994765	+	Silent	SNP	G	G	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr17:61994765G>A	uc002jdj.2	-	5	620	c.558C>T	c.(556-558)TAC>TAT	p.Y186Y	GH1_uc002jdi.2_Silent_p.Y171Y|GH1_uc002jdk.2_Silent_p.Y146Y|GH1_uc002jdl.2_Silent_p.Y91Y|GH1_uc002jdm.2_3'UTR|GH1_uc002jdn.2_Missense_Mutation_p.T140M	NM_000515	NP_000506	P01241	SOMA_HUMAN	growth hormone 1 isoform 1	186					glucose transport|growth hormone receptor signaling pathway|JAK-STAT cascade|positive regulation of activation of JAK2 kinase activity|positive regulation of insulin-like growth factor receptor signaling pathway|positive regulation of MAP kinase activity|positive regulation of multicellular organism growth|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of tyrosine phosphorylation of Stat5 protein|response to estradiol stimulus	extracellular space	growth factor activity|growth hormone receptor binding|hormone activity|metal ion binding|prolactin receptor binding				0						AGAGCAGCCCGTAGTTCTTGA	0.567			NA											28	131					0	0	0.002445	0	0
SMURF2	64750	broad.mit.edu	37	17	62553734	62553734	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr17:62553734C>A	uc002jep.1	-	13	1811	c.1423G>T	c.(1423-1425)GTT>TTT	p.V475F	SMURF2_uc002jeq.1_Missense_Mutation_p.V234F|SMURF2_uc002jer.1_Missense_Mutation_p.V234F	NM_022739	NP_073576	Q9HAU4	SMUF2_HUMAN	SMAD specific E3 ubiquitin protein ligase 2	475	HECT.				BMP signaling pathway|negative regulation of transcription, DNA-dependent|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|regulation of transforming growth factor beta receptor signaling pathway|transforming growth factor beta receptor signaling pathway|ubiquitin-dependent SMAD protein catabolic process	cytosol|membrane raft|nucleus|plasma membrane|ubiquitin ligase complex	identical protein binding|SMAD binding|ubiquitin-protein ligase activity			skin(3)|lung(1)	4	Breast(5;1.32e-14)		BRCA - Breast invasive adenocarcinoma(8;9.88e-12)			ACCGGATTAACTGCAGAATCA	0.313			NA											12	95					2.68362e-12	3.93545e-12	0.001368	1	0
RGS9	8787	broad.mit.edu	37	17	63149633	63149633	+	Missense_Mutation	SNP	A	A	C			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr17:63149633A>C	uc002jfe.2	+	2	261	c.151A>C	c.(151-153)ACA>CCA	p.T51P	RGS9_uc010dem.2_Missense_Mutation_p.T51P|RGS9_uc002jfd.2_Missense_Mutation_p.T51P|RGS9_uc002jff.2_RNA	NM_003835	NP_003826	O75916	RGS9_HUMAN	regulator of G-protein signaling 9 isoform 1	51	DEP.				intracellular signal transduction|negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway|visual perception	cytoplasm|heterotrimeric G-protein complex	GTPase activator activity|signal transducer activity			ovary(2)|skin(2)	4						TCATGCCATGACAGGTGATGT	0.498			NA											7	94					0	0	0.00308	0	0
CACNG5	27091	broad.mit.edu	37	17	64881147	64881147	+	Silent	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr17:64881147G>T	uc010wqi.1	+	6	855	c.618G>T	c.(616-618)GCG>GCT	p.A206A	CACNG5_uc010wqj.1_Silent_p.A206A	NM_145811	NP_665810	Q9UF02	CCG5_HUMAN	voltage-dependent calcium channel gamma-5	206				SAGVMSVYLFMKRYTAEDMYRPHPGFYRPRLSNCSDYSGQF LHPDAWVRGRSPSDISSEASLQMNSNYPALLKCPDYDQMSS SPC -> VKPVTLSMDRLGLGTAPLSRGEWGWGRRDIPQPF WTPDHPLYFPSSSQNVSLSYLSGSPPARMSPGPCSCPHVHF PPHSSCVLCRPQPREMRQAPAASPSSAVFSL (in Ref. 1; AAF03089).	regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|postsynaptic density|postsynaptic membrane	voltage-gated calcium channel activity			pancreas(1)|skin(1)	2			BRCA - Breast invasive adenocarcinoma(6;1.61e-08)			GGTACACCGCGGAGGACATGT	0.612			NA											27	42					4.74835e-14	7.16833e-14	0.002096	1	0
NOL11	25926	broad.mit.edu	37	17	65739938	65739938	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr17:65739938G>C	uc002jgd.1	+	18	2126	c.2123G>C	c.(2122-2124)AGA>ACA	p.R708T	NOL11_uc010wql.1_Missense_Mutation_p.R526T|NOL11_uc010deu.1_Missense_Mutation_p.R303T	NM_015462	NP_056277	Q9H8H0	NOL11_HUMAN	nucleolar protein 11	708						nucleolus					0	all_cancers(12;1.54e-10)		BRCA - Breast invasive adenocarcinoma(8;7.48e-08)|Colorectal(3;0.0518)|COAD - Colon adenocarcinoma(4;0.0977)|LUSC - Lung squamous cell carcinoma(166;0.24)			AAGAATAATAGAGGATTATAT	0.318			NA											7	40					0	0	0.001984	0	0
ABCA9	10350	broad.mit.edu	37	17	67023203	67023203	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr17:67023203C>G	uc002jhu.2	-	15	2107	c.1964G>C	c.(1963-1965)CGA>CCA	p.R655P	ABCA9_uc010dez.2_Missense_Mutation_p.R655P	NM_080283	NP_525022	Q8IUA7	ABCA9_HUMAN	ATP-binding cassette, sub-family A, member 9	655	ABC transporter 1.				transport	integral to membrane	ATP binding|ATPase activity			ovary(4)|upper_aerodigestive_tract(1)|central_nervous_system(1)	6	Breast(10;1.47e-12)					ATTCCATATTCGGTGCCTTGA	0.433			NA											40	45					0	0	0.002522	0	0
KCNJ2	3759	broad.mit.edu	37	17	68171232	68171232	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr17:68171232G>T	uc010dfg.2	+	2	453	c.52G>T	c.(52-54)GGT>TGT	p.G18C	KCNJ2_uc002jir.2_Missense_Mutation_p.G18C	NM_000891	NP_000882	P63252	IRK2_HUMAN	potassium inwardly-rectifying channel J2	18	Cytoplasmic (By similarity).				synaptic transmission	integral to plasma membrane	inward rectifier potassium channel activity|protein binding				0	Breast(10;1.64e-08)					AGAAGAAGACGGTATGAAGTT	0.522			NA											21	34					1.9806e-07	2.50438e-07	0.002299	1	0
SDK2	54549	broad.mit.edu	37	17	71387661	71387661	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr17:71387661C>A	uc010dfm.2	-	28	3915	c.3915G>T	c.(3913-3915)ATG>ATT	p.M1305I	SDK2_uc002jjt.3_Missense_Mutation_p.M464I|SDK2_uc010dfn.2_Missense_Mutation_p.M984I	NM_001144952	NP_001138424	Q58EX2	SDK2_HUMAN	sidekick 2	1305	Fibronectin type-III 8.|Extracellular (Potential).				cell adhesion	integral to membrane				ovary(2)	2						ACAGGATGCCCATGGGTGGTC	0.662			NA											10	9					0.000442599	0.000487515	0.006214	1	0
SDK2	54549	broad.mit.edu	37	17	71389876	71389876	+	Nonsense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr17:71389876C>A	uc010dfm.2	-	27	3721	c.3721G>T	c.(3721-3723)GAG>TAG	p.E1241*	SDK2_uc002jjt.3_Nonsense_Mutation_p.E400*|SDK2_uc010dfn.2_Nonsense_Mutation_p.E920*	NM_001144952	NP_001138424	Q58EX2	SDK2_HUMAN	sidekick 2	1241	Fibronectin type-III 7.|Extracellular (Potential).				cell adhesion	integral to membrane				ovary(2)	2						GAGTCCTTCTCCTTATACATC	0.587			NA											18	22					4.26978e-12	6.21857e-12	0.00333	1	0
DNAI2	64446	broad.mit.edu	37	17	72277988	72277988	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr17:72277988G>T	uc002jkf.2	+	2	131	c.32G>T	c.(31-33)CGC>CTC	p.R11L	DNAI2_uc002jkg.2_RNA|DNAI2_uc010dfp.2_RNA	NM_023036	NP_075462	Q9GZS0	DNAI2_HUMAN	dynein, axonemal, intermediate polypeptide 2	11					cilium assembly	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	microtubule motor activity			ovary(2)|central_nervous_system(1)	3						GTCAAGAAGCGCAGCGAGTTC	0.637			NA							Kartagener_syndrome				15	92					1.56452e-12	2.31028e-12	0.007413	1	0
CD300LB	124599	broad.mit.edu	37	17	72521974	72521974	+	Missense_Mutation	SNP	T	T	C	rs113622355		TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr17:72521974T>C	uc002jkx.2	-	2	407	c.394A>G	c.(394-396)AGG>GGG	p.R132G	CD300LB_uc010wqz.1_Missense_Mutation_p.R132G	NM_174892	NP_777552	A8K4G0	CLM7_HUMAN	CD300 molecule-like family member b	95	Ig-like V-type.|Extracellular (Potential).					integral to membrane|plasma membrane	receptor activity			ovary(1)	1						TCATCTCGCCTGAGCCCCTCC	0.507			NA											48	143					0	0	0.00361	0	0
CD300LD	100131439	broad.mit.edu	37	17	72578359	72578359	+	Silent	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr17:72578359G>T	uc002jkz.2	-	3	500	c.471C>A	c.(469-471)ACC>ACA	p.T157T	C17orf77_uc002jla.1_5'Flank	NM_001115152	NP_001108624	Q6UXZ3	CLM4_HUMAN	CD300 molecule-like family member d precursor	157	Extracellular (Potential).					integral to membrane|plasma membrane	receptor activity				0						CCACCTACCTGGTGAGGGGGC	0.478			NA											14	47					1.15088e-07	1.4602e-07	0.004007	1	0
CD300E	342510	broad.mit.edu	37	17	72613290	72613290	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr17:72613290G>T	uc002jlb.1	-	2	396	c.355C>A	c.(355-357)CCC>ACC	p.P119T		NM_181449	NP_852114	Q496F6	CLM2_HUMAN	CD300e molecule precursor	119	Ig-like V-type.|Extracellular (Potential).					integral to membrane|plasma membrane	receptor activity			skin(2)|large_intestine(1)|ovary(1)	4						AGGTCCGAGGGATCGCGTGAC	0.547			NA											32	113					2.20474e-14	3.3625e-14	0.003755	1	0
MGAT5B	146664	broad.mit.edu	37	17	74901414	74901414	+	Missense_Mutation	SNP	A	A	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr17:74901414A>T	uc002jti.2	+	6	990	c.887A>T	c.(886-888)CAG>CTG	p.Q296L	MGAT5B_uc002jth.2_Missense_Mutation_p.Q285L	NM_198955	NP_945193	Q3V5L5	MGT5B_HUMAN	N-acetylglucosaminyltranferase VB isoform 2	285	Lumenal (Potential).					Golgi membrane|integral to membrane	alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase activity|metal ion binding			ovary(2)|skin(1)	3						GACCAGAAGCAGGTGCGTGGC	0.622			NA											5	12					0	0	0.000602	0	0
CARD14	79092	broad.mit.edu	37	17	78169367	78169367	+	Nonsense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr17:78169367G>T	uc002jxw.1	+	11	1705	c.1510G>T	c.(1510-1512)GAG>TAG	p.E504*	CARD14_uc002jxt.1_RNA|CARD14_uc002jxv.2_Nonsense_Mutation_p.E504*|CARD14_uc010wud.1_RNA|CARD14_uc002jxx.2_Nonsense_Mutation_p.E267*|CARD14_uc010dhu.1_Nonsense_Mutation_p.E302*	NM_024110	NP_077015	Q9BXL6	CAR14_HUMAN	caspase recruitment domain protein 14 isoform 1	504					activation of NF-kappaB-inducing kinase activity|positive regulation of protein phosphorylation|regulation of apoptosis	aggresome|cytoplasm|plasma membrane	CARD domain binding			ovary(4)|skin(1)	5	all_neural(118;0.0952)		OV - Ovarian serous cystadenocarcinoma(97;0.017)|BRCA - Breast invasive adenocarcinoma(99;0.0908)			CAGCTGCCTGGAGATCCCGGA	0.647			NA											4	19					1.23904e-05	1.44506e-05	0.000602	1	0
RNF213	57674	broad.mit.edu	37	17	78350164	78350164	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr17:78350164C>T	uc002jyh.1	+	27	7691	c.7468C>T	c.(7468-7470)CGT>TGT	p.R2490C	uc002jyi.1_Intron|RNF213_uc010dhw.1_Missense_Mutation_p.R872C	NM_020914	NP_065965	Q9HCF4	ALO17_HUMAN	ring finger protein 213	Error:Variant_position_missing_in_Q9HCF4_after_alignment										ovary(8)|lung(6)|breast(3)|large_intestine(2)|central_nervous_system(1)|pancreas(1)	21	all_neural(118;0.0538)		BRCA - Breast invasive adenocarcinoma(99;0.0252)|OV - Ovarian serous cystadenocarcinoma(97;0.057)			TGATATCAGCCGTTTTGCAAC	0.453			NA											19	164					0	0	0.001882	0	0
BAIAP2	10458	broad.mit.edu	37	17	79080634	79080634	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr17:79080634G>A	uc002jzg.2	+	12	1535	c.1427G>A	c.(1426-1428)CGG>CAG	p.R476Q	BAIAP2_uc002jyz.3_Missense_Mutation_p.R476Q|BAIAP2_uc002jza.2_Missense_Mutation_p.R476Q|BAIAP2_uc002jzc.2_Missense_Mutation_p.R477Q|BAIAP2_uc002jzb.2_Missense_Mutation_p.R233Q|BAIAP2_uc002jzd.2_Missense_Mutation_p.R476Q|BAIAP2_uc002jzf.2_Missense_Mutation_p.R476Q|BAIAP2_uc002jze.2_Missense_Mutation_p.R509Q|BAIAP2_uc010wuh.1_Missense_Mutation_p.R398Q|BAIAP2_uc002jzh.2_Missense_Mutation_p.R477Q|BAIAP2_uc010wui.1_Missense_Mutation_p.R339Q	NM_017451	NP_059345	Q9UQB8	BAIP2_HUMAN	BAI1-associated protein 2 isoform 2	476					axonogenesis|filopodium assembly|insulin receptor signaling pathway|regulation of actin cytoskeleton organization|response to bacterium	cell junction|cytoskeleton|cytosol|filopodium|nucleus|ruffle	cytoskeletal adaptor activity|proline-rich region binding|protein C-terminus binding|SH3 domain binding				0	all_neural(118;0.101)		BRCA - Breast invasive adenocarcinoma(99;0.0228)|OV - Ovarian serous cystadenocarcinoma(97;0.0524)			GCCGCCTCCCGGGCCTTCCCC	0.706			NA											6	41					0	0	0.001168	0	0
CSNK1D	1453	broad.mit.edu	37	17	80231249	80231249	+	Silent	SNP	C	C	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr17:80231249C>T	uc002kej.2	-	1	325	c.9G>A	c.(7-9)CTG>CTA	p.L3L	CSNK1D_uc002kef.2_Silent_p.L3L|CSNK1D_uc002kei.2_Silent_p.L3L|CSNK1D_uc010wvj.1_5'UTR	NM_001893	NP_001884	P48730	KC1D_HUMAN	casein kinase 1, delta isoform 1	3					circadian regulation of gene expression|DNA repair|G2/M transition of mitotic cell cycle|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|regulation of circadian rhythm|Wnt receptor signaling pathway	centrosome|cytosol|nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			breast(2)	2	Breast(20;0.00136)|all_neural(118;0.0804)|Lung NSC(278;0.128)|all_lung(278;0.145)|Ovarian(332;0.227)		OV - Ovarian serous cystadenocarcinoma(97;0.00463)|BRCA - Breast invasive adenocarcinoma(99;0.0155)			TCCCGACTCTCAGCTCCATGG	0.592			NA											3	20					0	0	0.000602	0	0
CSNK1D	1453	broad.mit.edu	37	17	80231254	80231254	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr17:80231254C>G	uc002kej.2	-	1	320	c.4G>C	c.(4-6)GAG>CAG	p.E2Q	CSNK1D_uc002kef.2_Missense_Mutation_p.E2Q|CSNK1D_uc002kei.2_Missense_Mutation_p.E2Q|CSNK1D_uc010wvj.1_5'UTR	NM_001893	NP_001884	P48730	KC1D_HUMAN	casein kinase 1, delta isoform 1	2					circadian regulation of gene expression|DNA repair|G2/M transition of mitotic cell cycle|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|regulation of circadian rhythm|Wnt receptor signaling pathway	centrosome|cytosol|nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			breast(2)	2	Breast(20;0.00136)|all_neural(118;0.0804)|Lung NSC(278;0.128)|all_lung(278;0.145)|Ovarian(332;0.227)		OV - Ovarian serous cystadenocarcinoma(97;0.00463)|BRCA - Breast invasive adenocarcinoma(99;0.0155)			ACTCTCAGCTCCATGGCGGCG	0.612			NA											3	21					0	0	0.000602	0	0
ADCYAP1	116	broad.mit.edu	37	18	905486	905486	+	Silent	SNP	C	C	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr18:905486C>T	uc010dkg.2	+	2	218	c.99C>T	c.(97-99)TTC>TTT	p.F33F	ADCYAP1_uc010dkh.2_Silent_p.F33F	NM_001099733	NP_001093203	P18509	PACA_HUMAN	adenylate cyclase activating polypeptide	33					activation of adenylate cyclase activity|cell-cell signaling|female pregnancy|nerve growth factor receptor signaling pathway|regulation of G-protein coupled receptor protein signaling pathway	extracellular region|soluble fraction	neuropeptide hormone activity|peptide hormone receptor binding				0						GACTCCGGTTCCCCGGGATCA	0.632			NA											13	38					0	0	0.001368	0	0
EMILIN2	84034	broad.mit.edu	37	18	2891683	2891683	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr18:2891683G>T	uc002kln.2	+	4	1717	c.1558G>T	c.(1558-1560)GGG>TGG	p.G520W		NM_032048	NP_114437	Q9BXX0	EMIL2_HUMAN	elastin microfibril interfacer 2 precursor	520					cell adhesion	collagen	extracellular matrix constituent conferring elasticity|protein binding			skin(2)|ovary(1)	3				READ - Rectum adenocarcinoma(2;0.1)		CAGTCCCCCAGGGGCAGCAGC	0.507			NA											17	49					2.23348e-06	2.71339e-06	0.004007	1	0
LAMA1	284217	broad.mit.edu	37	18	6965403	6965403	+	Missense_Mutation	SNP	C	C	A	rs141811330		TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr18:6965403C>A	uc002knm.2	-	50	7173	c.7079G>T	c.(7078-7080)CGT>CTT	p.R2360L	LAMA1_uc002knl.2_5'UTR|LAMA1_uc010wzj.1_Missense_Mutation_p.R1836L	NM_005559	NP_005550	P25391	LAMA1_HUMAN	laminin, alpha 1 precursor	2360	Laminin G-like 2.				axon guidance|cell adhesion|cell surface receptor linked signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	extracellular space|laminin-1 complex|laminin-3 complex	extracellular matrix structural constituent|receptor binding			ovary(8)|large_intestine(4)|upper_aerodigestive_tract(2)|breast(2)|skin(2)|pancreas(2)|central_nervous_system(1)	21		Colorectal(10;0.172)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	CACTCTGCCACGAAACAGCTC	0.443			NA											13	56					0.000308642	0.000341227	0.003163	1	0
KIAA0802	23255	broad.mit.edu	37	18	8798277	8798277	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr18:8798277G>T	uc002knr.2	+	10	2566	c.2424G>T	c.(2422-2424)CAG>CAT	p.Q808H	KIAA0802_uc002knq.2_Missense_Mutation_p.Q767H|KIAA0802_uc002kns.2_Missense_Mutation_p.Q138H	NM_015210	NP_056025	Q9Y4B5	CC165_HUMAN	hypothetical protein LOC23255	1118											0						ACAGGGGACAGCCCCACAAAC	0.627			NA											7	26					0.00448238	0.00476433	0.004482	1	0
MC5R	4161	broad.mit.edu	37	18	13826379	13826379	+	Nonsense_Mutation	SNP	C	C	G			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr18:13826379C>G	uc010xaf.1	+	1	615	c.615C>G	c.(613-615)TAC>TAG	p.Y205*		NM_005913	NP_005904	P33032	MC5R_HUMAN	melanocortin 5 receptor	205	Helical; Name=5; (Potential).				G-protein signaling, coupled to cyclic nucleotide second messenger|positive regulation of cAMP biosynthetic process	integral to plasma membrane	melanocortin receptor activity|protein binding			ovary(3)|lung(2)|breast(1)	6						TGTCTCTGTACATACACATGT	0.597			NA											127	408					0	0	0.00361	0	0
ANKRD30B	374860	broad.mit.edu	37	18	14752928	14752928	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr18:14752928C>G	uc010dlo.2	+	3	607	c.427C>G	c.(427-429)CTC>GTC	p.L143V	ANKRD30B_uc010xak.1_RNA	NM_001145029	NP_001138501	Q9BXX2	AN30B_HUMAN	ankyrin repeat domain 30B	143	ANK 3.									ovary(1)|skin(1)	2						CAACACGGCTCTCCATTATGC	0.433			NA											2	6					0	0	0.004672	0	0
ANKRD30B	374860	broad.mit.edu	37	18	14799128	14799128	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr18:14799128G>T	uc010dlo.2	+	21	2238	c.2058G>T	c.(2056-2058)AAG>AAT	p.K686N	ANKRD30B_uc010xak.1_RNA	NM_001145029	NP_001138501	Q9BXX2	AN30B_HUMAN	ankyrin repeat domain 30B	737										ovary(1)|skin(1)	2						GTCTTCTGAAGGTAATAACTT	0.294			NA											4	38					0.00024832	0.000277424	0.009096	1	0
GATA6	2627	broad.mit.edu	37	18	19751152	19751152	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr18:19751152C>A	uc002ktt.1	+	2	312	c.47C>A	c.(46-48)GCC>GAC	p.A16D	GATA6_uc002ktu.1_Missense_Mutation_p.A16D	NM_005257	NP_005248	Q92908	GATA6_HUMAN	GATA binding protein 6	16					blood coagulation|cardiac vascular smooth muscle cell differentiation|cellular response to hypoxia|intestinal epithelial cell differentiation|male gonad development|negative regulation of apoptosis|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transforming growth factor-beta1 production|negative regulation of transforming growth factor-beta2 production|outflow tract septum morphogenesis|positive regulation of angiogenesis|positive regulation of cell cycle arrest|positive regulation of transcription from RNA polymerase II promoter|response to drug|response to growth factor stimulus		protein binding|protein kinase binding|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription regulatory region DNA binding|zinc ion binding			central_nervous_system(3)	3	all_cancers(21;0.00271)|all_epithelial(16;7.31e-05)|Ovarian(2;0.116)|Lung NSC(20;0.123)|all_lung(20;0.246)		STAD - Stomach adenocarcinoma(5;0.106)			CGCTTCGGGGCCGCGGGTGCG	0.716	Colon(8;48 282 46199 46856)|Melanoma(177;170 2725 12489 26999)		NA											10	18					3.86212e-05	4.42789e-05	0.008291	1	0
DSG2	1829	broad.mit.edu	37	18	29111197	29111197	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr18:29111197G>C	uc002kwu.3	+	9	1450	c.1262G>C	c.(1261-1263)GGA>GCA	p.G421A		NM_001943	NP_001934	Q14126	DSG2_HUMAN	desmoglein 2 preproprotein	421	Extracellular (Potential).|Cadherin 4.				cellular component disassembly involved in apoptosis|homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			central_nervous_system(5)|ovary(2)|breast(1)|skin(1)	9			OV - Ovarian serous cystadenocarcinoma(10;0.0068)			GAGGACACTGGACTACCAGCC	0.348			NA											22	53					0	0	0.00632	0	0
C18orf34	374864	broad.mit.edu	37	18	30791939	30791939	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr18:30791939C>A	uc002kxn.2	-	19	2301	c.2159G>T	c.(2158-2160)TGT>TTT	p.C720F	C18orf34_uc010dme.1_Missense_Mutation_p.C234F|C18orf34_uc010xbr.1_Missense_Mutation_p.C720F|C18orf34_uc010dmf.1_Intron|C18orf34_uc002kxo.2_Missense_Mutation_p.C682F|C18orf34_uc002kxp.2_Missense_Mutation_p.C720F	NM_001105528	NP_001098998	Q5BJE1	CR034_HUMAN	hypothetical protein LOC374864 isoform 1	720										ovary(1)	1						TCTCTCTTCACAGTCTTTTTT	0.333			NA											7	13					1.26484e-09	1.72553e-09	0.00308	1	0
SETBP1	26040	broad.mit.edu	37	18	42281594	42281594	+	Nonsense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr18:42281594G>T	uc010dni.2	+	2	579	c.283G>T	c.(283-285)GAG>TAG	p.E95*	SETBP1_uc002lay.2_Nonsense_Mutation_p.E95*	NM_015559	NP_056374	Q9Y6X0	SETBP_HUMAN	SET binding protein 1 isoform a	95						nucleus	DNA binding			upper_aerodigestive_tract(2)|large_intestine(1)	3				Colorectal(1;0.0622)|COAD - Colon adenocarcinoma(74;0.201)		TTCTATCAAGGAGGCAAACTT	0.478			NA							Schinzel-Giedion_syndrome				25	40					5.45727e-16	8.60547e-16	0.008361	1	0
SLC14A2	8170	broad.mit.edu	37	18	43204627	43204627	+	Translation_Start_Site	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr18:43204627G>T	uc010dnj.2	+	3	319	c.-2G>T	c.(-4-0)AAGGA>AATGA		SLC14A2_uc002lbb.2_Translation_Start_Site|SLC14A2_uc002lbe.2_Translation_Start_Site	NM_007163	NP_009094	Q15849	UT2_HUMAN	solute carrier family 14 (urea transporter),							apical plasma membrane|integral to membrane|membrane fraction	protein binding|urea transmembrane transporter activity			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)|skin(1)	4						GTGACCCGAAGGAATGTCTGA	0.577			NA											19	24					4.76136e-26	8.31979e-26	0.00278	1	0
DYM	54808	broad.mit.edu	37	18	46812949	46812949	+	Silent	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr18:46812949G>T	uc002ldi.1	-	9	1166	c.801C>A	c.(799-801)GGC>GGA	p.G267G	DYM_uc010xdf.1_Silent_p.G77G|DYM_uc002ldj.3_Silent_p.G89G	NM_017653	NP_060123	Q7RTS9	DYM_HUMAN	dymeclin	267						Golgi apparatus					0						CCGCTTTGCTGCCCACACCAC	0.537			NA											7	17					0.000157383	0.000177026	0.00308	1	0
TCF4	6925	broad.mit.edu	37	18	52896169	52896169	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr18:52896169C>A	uc002lfz.2	-	18	2388	c.1776G>T	c.(1774-1776)CAG>CAT	p.Q592H	TCF4_uc002lfw.3_Missense_Mutation_p.Q436H|TCF4_uc010xdu.1_Missense_Mutation_p.Q462H|TCF4_uc010xdv.1_Missense_Mutation_p.Q462H|TCF4_uc002lfx.2_Missense_Mutation_p.Q525H|TCF4_uc010xdw.1_Missense_Mutation_p.Q462H|TCF4_uc002lfy.2_Missense_Mutation_p.Q550H|TCF4_uc010xdx.1_Missense_Mutation_p.Q568H|TCF4_uc010dph.1_Missense_Mutation_p.Q596H|TCF4_uc010xdy.1_Missense_Mutation_p.Q572H|TCF4_uc002lga.2_Missense_Mutation_p.Q698H|TCF4_uc002lgb.1_Missense_Mutation_p.Q432H|TCF4_uc010dpi.2_Missense_Mutation_p.Q602H|TCF4_uc002lfv.2_Missense_Mutation_p.Q375H	NM_003199	NP_003190	P15884	ITF2_HUMAN	transcription factor 4 isoform b	592	Helix-loop-helix motif.				positive regulation of neuron differentiation|protein-DNA complex assembly|transcription initiation from RNA polymerase II promoter	transcription factor complex	E-box binding|protein C-terminus binding|protein heterodimerization activity|RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|sequence-specific DNA binding RNA polymerase recruiting transcription factor activity|TFIIB-class binding transcription factor activity|TFIIB-class transcription factor binding			ovary(1)|lung(1)	2				Colorectal(16;0.00108)|READ - Rectum adenocarcinoma(59;0.0649)|COAD - Colon adenocarcinoma(17;0.0718)		TGAGGTGGAGCTGCACCATGC	0.612			NA											23	27					4.7796e-09	6.37996e-09	0.004656	1	0
CCBE1	147372	broad.mit.edu	37	18	57106909	57106909	+	Silent	SNP	C	C	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr18:57106909C>T	uc002lib.2	-	8	985	c.915G>A	c.(913-915)GTG>GTA	p.V305V	CCBE1_uc010dpq.2_Intron|CCBE1_uc002lia.2_Silent_p.V158V	NM_133459	NP_597716	Q6UXH8	CCBE1_HUMAN	collagen and calcium binding EGF domains 1	305	Collagen-like 2.				lymphangiogenesis|sprouting angiogenesis|venous blood vessel morphogenesis	collagen	calcium ion binding			skin(2)|ovary(1)	3		Colorectal(73;0.175)				AGATACTGACCACAGGGCCCC	0.542	NSCLC(137;1340 1860 15773 39604 51087)|Esophageal Squamous(139;339 1777 2926 19691 38524)		NA											20	60					0	0	0.002299	0	0
DSEL	92126	broad.mit.edu	37	18	65178663	65178663	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr18:65178663C>A	uc002lke.1	-	2	4437	c.3213G>T	c.(3211-3213)TTG>TTT	p.L1071F		NM_032160	NP_115536	Q8IZU8	DSEL_HUMAN	dermatan sulfate epimerase-like	1061						integral to membrane	isomerase activity|sulfotransferase activity			ovary(3)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	6		Esophageal squamous(42;0.129)				CTATTTTAAACAATTTTGCTA	0.333			NA											10	17					2.17888e-05	2.52532e-05	0.006214	1	0
ZNF236	7776	broad.mit.edu	37	18	74610973	74610973	+	Splice_Site	SNP	A	A	G			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr18:74610973A>G	uc002lmi.2	+	11	1883	c.1685_splice	c.e11-2	p.G562_splice	ZNF236_uc002lmj.2_Splice_Site	NM_007345	NP_031371	Q9UL36	ZN236_HUMAN	zinc finger protein 236						cellular response to glucose stimulus	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)	4		Prostate(75;0.0405)|Esophageal squamous(42;0.129)|Melanoma(33;0.132)		OV - Ovarian serous cystadenocarcinoma(15;4.36e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0686)		CATTTTTATTAGGAGTTAGAC	0.323			NA											14	16					0	0	0.003163	0	0
FZR1	51343	broad.mit.edu	37	19	3527758	3527758	+	Silent	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr19:3527758G>T	uc010dtk.2	+	6	634	c.600G>T	c.(598-600)GTG>GTT	p.V200V	FZR1_uc002lxt.2_Silent_p.V200V|FZR1_uc002lxv.2_Intron	NM_001136198	NP_001129670	Q9UM11	FZR_HUMAN	Fzr1 protein isoform 1	200	WD 1.				activation of anaphase-promoting complex activity|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|DNA repair|G2/M transition DNA damage checkpoint|mitosis|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of protein catabolic process|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|S phase of mitotic cell cycle	cytosol|nucleoplasm	protein binding			lung(1)|kidney(1)	2				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00253)|STAD - Stomach adenocarcinoma(1328;0.18)		CCCTCAATGTGCTCAGCGTGG	0.632			NA											10	18					2.80697e-09	3.77735e-09	0.000978	1	0
PIP5K1C	23396	broad.mit.edu	37	19	3642905	3642905	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr19:3642905C>G	uc002lyj.1	-	14	1739	c.1682G>C	c.(1681-1683)AGG>ACG	p.R561T	PIP5K1C_uc010xhq.1_Missense_Mutation_p.R561T|PIP5K1C_uc010xhr.1_Missense_Mutation_p.R561T	NM_012398	NP_036530	O60331	PI51C_HUMAN	phosphatidylinositol-4-phosphate 5-kinase, type	561					axon guidance	cytosol|plasma membrane	1-phosphatidylinositol-4-phosphate 5-kinase activity|ATP binding			stomach(2)|skin(2)	4		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.95e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0026)|STAD - Stomach adenocarcinoma(1328;0.183)		TGGGTCTCACCTGCCATCCTG	0.542	Esophageal Squamous(135;99 1744 12852 27186 39851)		NA											19	42					0	0	0.003954	0	0
ZNRF4	148066	broad.mit.edu	37	19	5455761	5455761	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr19:5455761C>A	uc002mca.3	+	1	336	c.259C>A	c.(259-261)CTG>ATG	p.L87M		NM_181710	NP_859061	Q8WWF5	ZNRF4_HUMAN	zinc and ring finger 4 precursor	87	Extracellular (Potential).					integral to membrane	zinc ion binding			large_intestine(2)	2				UCEC - Uterine corpus endometrioid carcinoma (162;0.0002)		CAAAGCCTTGCTGGTCTTGTC	0.672			NA											17	38					2.48551e-13	3.722e-13	0.00499	1	0
EVI5L	115704	broad.mit.edu	37	19	7916418	7916418	+	Silent	SNP	C	C	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr19:7916418C>T	uc002min.2	+	7	1006	c.852C>T	c.(850-852)TTC>TTT	p.F284F	EVI5L_uc010xjz.1_Silent_p.F284F|EVI5L_uc002mio.1_Silent_p.F15F	NM_145245	NP_660288	Q96CN4	EVI5L_HUMAN	ecotropic viral integration site 5-like isoform	284	Rab-GAP TBC.					intracellular	protein binding|Rab GTPase activator activity			ovary(1)	1						TGACCACCTTCCCACTCCCCG	0.587			NA											9	75					0	0	0.001855	0	0
MUC16	94025	broad.mit.edu	37	19	8982316	8982316	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr19:8982316C>A	uc002mkp.2	-	70	42163	c.41959G>T	c.(41959-41961)GGT>TGT	p.G13987C	MUC16_uc010dwi.2_RNA|MUC16_uc010dwj.2_Missense_Mutation_p.G804C|MUC16_uc010xki.1_RNA	NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	14012	Extracellular (Potential).|SEA 13.			Missing (in Ref. 3; AAK74120).	cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GTCTCAGCACCGTTCTTCACA	0.468			NA											16	30					3.62473e-10	5.0186e-10	0.001882	1	0
MUC16	94025	broad.mit.edu	37	19	9060335	9060335	+	Silent	SNP	T	T	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr19:9060335T>A	uc002mkp.2	-	3	27315	c.27111A>T	c.(27109-27111)ACA>ACT	p.T9037T		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	9039	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						ACATGACTTGTGTCATGGAGT	0.527			NA											14	22					0	0	0.004007	0	0
MUC16	94025	broad.mit.edu	37	19	9076225	9076225	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr19:9076225C>G	uc002mkp.2	-	3	11425	c.11221G>C	c.(11221-11223)GGG>CGG	p.G3741R		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	3742	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						AGAGATCTCCCAGTGTCCCAG	0.507			NA											24	44					0	0	0.00632	0	0
ZNF563	147837	broad.mit.edu	37	19	12432132	12432132	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr19:12432132C>T	uc002mtp.2	-	3	383	c.145G>A	c.(145-147)GAA>AAA	p.E49K	ZNF563_uc002mtq.2_Missense_Mutation_p.E49K	NM_145276	NP_660319	Q8TA94	ZN563_HUMAN	zinc finger protein 563	49	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						GTATTCTGTTCTTCCCATATC	0.313	GBM(39;623 795 5132 29510 31476)		NA											7	15					0	0	0.00308	0	0
ZNF490	57474	broad.mit.edu	37	19	12691789	12691789	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr19:12691789C>T	uc002mtz.2	-	5	1229	c.1100G>A	c.(1099-1101)TGT>TAT	p.C367Y		NM_020714	NP_065765	Q9ULM2	ZN490_HUMAN	zinc finger protein 490	367	C2H2-type 8.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						GGCTTCCCCACATTTCTTACA	0.413			NA											18	23					0	0	0.001882	0	0
OR7A5	26659	broad.mit.edu	37	19	14938234	14938234	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr19:14938234C>A	uc002mzw.2	-	1	1043	c.820G>T	c.(820-822)GCC>TCC	p.A274S	OR7A5_uc010xoa.1_Missense_Mutation_p.A274S	NM_017506	NP_059976	Q15622	OR7A5_HUMAN	olfactory receptor, family 7, subfamily A,	274	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(2)	2						ATCACTGAGGCTGTTGCACTT	0.473			NA											29	28					8.53417e-09	1.13004e-08	0.002836	1	0
UNC13A	23025	broad.mit.edu	37	19	17720884	17720884	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr19:17720884C>G	uc002nhd.2	-	42	4940	c.4940G>C	c.(4939-4941)TGG>TCG	p.W1647S		NM_001080421	NP_001073890	Q9UPW8	UN13A_HUMAN	unc-13 homolog A	1559	C2 3.				exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			ovary(3)	3						AGAAGTCTGCCACTTGAGGTC	0.502			NA											54	66					0	0	0.00361	0	0
COMP	1311	broad.mit.edu	37	19	18896308	18896308	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr19:18896308C>A	uc002nke.2	-	15	1753	c.1717G>T	c.(1717-1719)GGT>TGT	p.G573C	COMP_uc002nkd.2_Missense_Mutation_p.G540C|COMP_uc010xqj.1_Missense_Mutation_p.G520C	NM_000095	NP_000086	P49747	COMP_HUMAN	cartilage oligomeric matrix protein precursor	573	Mediates cell survival and induction of the IAP family of survival proteins.|TSP C-terminal.				anti-apoptosis|apoptosis|cell adhesion|limb development	extracellular space|proteinaceous extracellular matrix	calcium ion binding|collagen binding|extracellular matrix structural constituent|heparan sulfate proteoglycan binding|heparin binding				0						CGCTTCTCACCCACAGCCAGG	0.522			NA											45	53					1.72845e-40	3.16917e-40	0.00361	1	0
TM6SF2	53345	broad.mit.edu	37	19	19378887	19378887	+	Nonsense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr19:19378887C>A	uc002nmd.1	-	7	669	c.619G>T	c.(619-621)GAA>TAA	p.E207*	HAPLN4_uc002nmc.2_5'UTR	NM_001001524	NP_001001524	Q9BZW4	TM6S2_HUMAN	transmembrane 6 superfamily member 2	207						integral to membrane					0			Epithelial(12;0.0151)			TTTCTTTGTTCCTCTTGCACC	0.522			NA											17	7					1.99824e-07	2.51812e-07	0.00499	1	0
SF4	57794	broad.mit.edu	37	19	19414190	19414190	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr19:19414190C>G	uc002nmh.2	-	6	732	c.730G>C	c.(730-732)GAA>CAA	p.E244Q	SF4_uc002nmf.2_5'Flank|SF4_uc002nmg.2_5'UTR|SF4_uc002nmi.2_Missense_Mutation_p.E34Q|SF4_uc002nmj.2_Missense_Mutation_p.E34Q|SF4_uc010xqr.1_RNA|SF4_uc010xqs.1_RNA	NM_172231	NP_757386	Q8IWZ8	SUGP1_HUMAN	splicing factor 4	244					nuclear mRNA splicing, via spliceosome	nucleoplasm|spliceosomal complex	RNA binding				0						TTCTGTGCTTCCTTTCTTATC	0.527			NA											28	48					0	0	0.002836	0	0
ZNF253	56242	broad.mit.edu	37	19	19989306	19989306	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr19:19989306G>T	uc002noj.2	+	2	112	c.20G>T	c.(19-21)AGA>ATA	p.R7I	ZNF253_uc002nok.2_Intron|ZNF253_uc002nol.2_Intron	NM_021047	NP_066385	O75346	ZN253_HUMAN	zinc finger protein 253	7	KRAB.				negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						TTGCAATTTAGAGATGTGGCC	0.393			NA											39	57					5.82388e-19	9.55863e-19	0.00361	1	0
ZNF98	148198	broad.mit.edu	37	19	22574545	22574545	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr19:22574545C>T	uc002nqt.2	-	4	1614	c.1492G>A	c.(1492-1494)GCT>ACT	p.A498T		NM_001098626	NP_001092096	A6NK75	ZNF98_HUMAN	zinc finger protein 98	498	C2H2-type 12.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|skin(1)	2		all_cancers(12;0.0536)|all_lung(12;0.00187)|Lung NSC(12;0.0019)|all_epithelial(12;0.00542)|Hepatocellular(1079;0.244)				TGGTTAAAAGCTTTGCCACAT	0.403			NA											24	126					0	0	0.003271	0	0
ZNF492	57615	broad.mit.edu	37	19	22847456	22847456	+	Nonsense_Mutation	SNP	A	A	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr19:22847456A>T	uc002nqw.3	+	4	1229	c.985A>T	c.(985-987)AGA>TGA	p.R329*		NM_020855	NP_065906	Q9P255	ZN492_HUMAN	zinc finger protein 492	329	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_cancers(12;0.0266)|all_lung(12;0.00187)|Lung NSC(12;0.0019)|all_epithelial(12;0.00203)|Hepatocellular(1079;0.244)				TACACATAAGAGAATTCATTC	0.378			NA											8	7					0	0	0.006214	0	0
C19orf2	8725	broad.mit.edu	37	19	30505918	30505918	+	Missense_Mutation	SNP	A	A	G			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr19:30505918A>G	uc002nsr.2	+	11	1580	c.1550A>G	c.(1549-1551)GAA>GGA	p.E517G	C19orf2_uc002nsq.2_Intron|C19orf2_uc002nss.2_Missense_Mutation_p.E477G|C19orf2_uc002nst.2_Missense_Mutation_p.E441G	NM_003796	NP_003787	O94763	RMP_HUMAN	RPB5-mediating protein isoform a	517					protein folding|regulation of transcription from RNA polymerase II promoter|response to virus	DNA-directed RNA polymerase II, core complex|prefoldin complex	transcription corepressor activity|unfolded protein binding			ovary(1)|kidney(1)	2	Ovarian(5;0.000902)|Breast(6;0.0203)|Esophageal squamous(110;0.195)	Hepatocellular(1079;0.137)|Renal(1328;0.228)	STAD - Stomach adenocarcinoma(5;5.36e-06)|Lung(7;0.0144)|LUAD - Lung adenocarcinoma(5;0.115)	STAD - Stomach adenocarcinoma(1328;0.18)		GAAGCATCTGAAGAAACTGGA	0.433	Melanoma(75;661 1306 1472 28422 37948)		NA											24	49					0	0	0.003954	0	0
ZNF536	9745	broad.mit.edu	37	19	30935373	30935373	+	Missense_Mutation	SNP	T	T	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr19:30935373T>A	uc002nsu.1	+	2	1042	c.904T>A	c.(904-906)TGC>AGC	p.C302S	ZNF536_uc010edd.1_Missense_Mutation_p.C302S	NM_014717	NP_055532	O15090	ZN536_HUMAN	zinc finger protein 536	302	C2H2-type 4.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(7)|large_intestine(2)|skin(2)	11	Esophageal squamous(110;0.0834)					GCCCTACAAGTGCACGTTGTG	0.652			NA											22	86					0	0	0.003954	0	0
TSHZ3	57616	broad.mit.edu	37	19	31768675	31768675	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr19:31768675C>T	uc002nsy.3	-	2	2089	c.2024G>A	c.(2023-2025)CGG>CAG	p.R675Q		NM_020856	NP_065907	Q63HK5	TSH3_HUMAN	zinc finger protein 537	675					negative regulation of transcription, DNA-dependent|regulation of respiratory gaseous exchange by neurological system process	growth cone|nucleus	chromatin binding|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)|skin(2)|pancreas(1)|lung(1)	8	Esophageal squamous(110;0.226)					GCACCCATCCCGCGGGGGGCT	0.652			NA											25	34					0	0	0.00632	0	0
ZNF30	90075	broad.mit.edu	37	19	35434349	35434349	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr19:35434349G>T	uc010edp.1	+	5	857	c.479G>T	c.(478-480)GGA>GTA	p.G160V	ZNF30_uc002nxf.2_Missense_Mutation_p.G79V|ZNF30_uc010edq.1_Missense_Mutation_p.G161V|ZNF30_uc010edr.1_Missense_Mutation_p.G161V	NM_194325	NP_919306	P17039	ZNF30_HUMAN	zinc finger protein 30 isoform b	160	C2H2-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|central_nervous_system(1)	2	all_lung(56;8.38e-08)|Lung NSC(56;1.31e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0849)	GBM - Glioblastoma multiforme(1328;0.0265)		TTTAGTAATGGACATCAACTC	0.383			NA											20	20					8.10497e-08	1.03987e-07	0.010504	1	0
CD22	933	broad.mit.edu	37	19	35832310	35832310	+	Silent	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr19:35832310G>T	uc010edt.2	+	8	1649	c.1572G>T	c.(1570-1572)TCG>TCT	p.S524S	CD22_uc010xst.1_Silent_p.S352S|CD22_uc010edu.2_Silent_p.S436S|CD22_uc010edv.2_Silent_p.S524S|CD22_uc002nzb.3_Silent_p.S347S|CD22_uc010edx.2_RNA	NM_001771	NP_001762	P20273	CD22_HUMAN	CD22 molecule precursor	524	Extracellular (Potential).|Ig-like C2-type 5.				cell adhesion		protein binding|sugar binding			ovary(5)|lung(3)|breast(1)	9	all_lung(56;9.78e-09)|Lung NSC(56;1.46e-08)|Esophageal squamous(110;0.162)		Epithelial(14;5.83e-19)|OV - Ovarian serous cystadenocarcinoma(14;3.19e-18)|all cancers(14;3.41e-16)|LUSC - Lung squamous cell carcinoma(66;0.0417)		OspA lipoprotein(DB00045)	CTGGAAACTCGGTCAGCCTCC	0.552	Ovarian(42;1009 1133 23674 26041)		NA											26	33					7.01153e-11	9.89198e-11	0.007291	1	0
TMEM149	79713	broad.mit.edu	37	19	36231335	36231335	+	Silent	SNP	G	G	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr19:36231335G>A	uc002obc.2	-	3	389	c.288C>T	c.(286-288)GCC>GCT	p.A96A	TMEM149_uc002obb.2_Intron|TMEM149_uc002obd.3_Silent_p.A96A|TMEM149_uc010xsy.1_RNA|TMEM149_uc010eej.2_Silent_p.A176A	NM_024660	NP_078936	Q9H665	IGFR1_HUMAN	transmembrane protein 149 precursor	96	Extracellular (Potential).					integral to membrane|plasma membrane	protein binding|receptor activity				0	all_lung(56;3.33e-07)|Lung NSC(56;5.02e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			TAGGGGTCACGGCTCCGCCGC	0.697			NA											6	25					0	0	0.001168	0	0
ZNF570	148268	broad.mit.edu	37	19	37975292	37975292	+	Silent	SNP	C	C	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr19:37975292C>T	uc002ogk.1	+	5	1297	c.768C>T	c.(766-768)AGC>AGT	p.S256S	ZNF570_uc010efl.1_Silent_p.S312S|ZNF570_uc010xtr.1_Silent_p.S53S	NM_144694	NP_653295	Q96NI8	ZN570_HUMAN	zinc finger protein 570	256	C2H2-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			AAGCCTTCAGCCAGAGATCAA	0.398			NA											30	101					0	0	0.002096	0	0
SIPA1L3	23094	broad.mit.edu	37	19	38572907	38572907	+	Silent	SNP	G	G	C			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr19:38572907G>C	uc002ohk.2	+	3	1211	c.702G>C	c.(700-702)GGG>GGC	p.G234G		NM_015073	NP_055888	O60292	SI1L3_HUMAN	signal-induced proliferation-associated 1 like	234					regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			ovary(1)|central_nervous_system(1)	2			Lung(45;0.000246)|LUSC - Lung squamous cell carcinoma(53;0.000292)			ACGCCCGAGGGTGCCAGGCCC	0.697			NA											48	49					0	0	0.00361	0	0
RYR1	6261	broad.mit.edu	37	19	38969098	38969098	+	Missense_Mutation	SNP	T	T	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr19:38969098T>A	uc002oit.2	+	31	4608	c.4478T>A	c.(4477-4479)ATG>AAG	p.M1493K	RYR1_uc002oiu.2_Missense_Mutation_p.M1493K	NM_000540	NP_000531	P21817	RYR1_HUMAN	skeletal muscle ryanodine receptor isoform 1	1493	Cytoplasmic.|B30.2/SPRY 3.|6 X approximate repeats.				muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(7)|pancreas(2)|breast(1)|central_nervous_system(1)|skin(1)	12	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	AACTGCTACATGGTGTGGGGC	0.602			NA											15	46					0	0	0.00499	0	0
MAP4K1	11184	broad.mit.edu	37	19	39104562	39104562	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr19:39104562G>T	uc002oix.1	-	8	599	c.491C>A	c.(490-492)GCT>GAT	p.A164D	MAP4K1_uc002oiy.1_Missense_Mutation_p.A164D|MAP4K1_uc010xug.1_5'UTR	NM_007181	NP_009112	Q92918	M4K1_HUMAN	mitogen-activated protein kinase kinase kinase	164	Protein kinase.				activation of JUN kinase activity|peptidyl-serine phosphorylation		ATP binding|MAP kinase kinase kinase kinase activity|protein binding|small GTPase regulator activity			skin(4)|lung(3)|ovary(1)	8	all_cancers(60;6.42e-06)|Ovarian(47;0.103)		Lung(45;0.000751)|LUSC - Lung squamous cell carcinoma(53;0.00272)			GGCCAGTGTAGCCCCAATCTG	0.627			NA											3	20					0.004672	0.00493414	0.004672	1	0
SPTBN4	57731	broad.mit.edu	37	19	41009848	41009848	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr19:41009848G>A	uc002ony.2	+	12	1560	c.1474G>A	c.(1474-1476)GCC>ACC	p.A492T	SPTBN4_uc002onx.2_Missense_Mutation_p.A492T|SPTBN4_uc002onz.2_Missense_Mutation_p.A492T	NM_020971	NP_066022	Q9H254	SPTN4_HUMAN	spectrin, beta, non-erythrocytic 4 isoform	492	Spectrin 3.				actin filament capping|axon guidance|cytoskeletal anchoring at plasma membrane|vesicle-mediated transport	cytosol|nuclear matrix|PML body|spectrin	actin binding|ankyrin binding|structural constituent of cytoskeleton			ovary(3)|central_nervous_system(1)|skin(1)	5			Lung(22;0.000114)|LUSC - Lung squamous cell carcinoma(20;0.000384)			GGCGGAGCTGGCCCAGGCATT	0.652			NA											19	37					0	0	0.001882	0	0
CEACAM6	4680	broad.mit.edu	37	19	42270096	42270096	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr19:42270096G>T	uc002orm.2	+	5	1113	c.964G>T	c.(964-966)GCT>TCT	p.A322S		NM_002483	NP_002474	P40199	CEAM6_HUMAN	carcinoembryonic antigen-related cell adhesion	322					cell-cell signaling|signal transduction	anchored to membrane|integral to plasma membrane				ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(3;0.00575)|all cancers(3;0.0352)|Epithelial(262;0.0797)		ACAAGGAAGTGCTCCTGTCCT	0.507			NA											22	98					2.00529e-23	3.43929e-23	0.00333	1	0
LYPD4	147719	broad.mit.edu	37	19	42341304	42341304	+	Silent	SNP	C	C	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr19:42341304C>T	uc002orp.1	-	5	1638	c.654G>A	c.(652-654)GAG>GAA	p.E218E	LYPD4_uc002orq.1_Silent_p.E183E	NM_173506	NP_775777	Q6UWN0	LYPD4_HUMAN	LY6/PLAUR domain containing 4 precursor	218	UPAR/Ly6.					anchored to membrane|plasma membrane				ovary(1)	1						TCTGAGACTTCTCTAAGATGT	0.498			NA											29	110					0	0	0.009535	0	0
PSG11	5680	broad.mit.edu	37	19	43519460	43519460	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr19:43519460C>T	uc002ovm.1	-	4	879	c.772G>A	c.(772-774)GAC>AAC	p.D258N	PSG11_uc002ouw.2_Intron|PSG10_uc002ouv.1_Intron|PSG6_uc002ovh.1_Intron|PSG6_uc002ovi.2_Intron|PSG6_uc010xwk.1_Intron|PSG11_uc002ovk.1_Intron|PSG11_uc002ovn.1_Missense_Mutation_p.D264N|PSG11_uc002ovo.1_Missense_Mutation_p.D136N|PSG11_uc002ovp.1_Missense_Mutation_p.D136N	NM_002785	NP_002776	Q9UQ72	PSG11_HUMAN	pregnancy specific beta-1-glycoprotein 11	258	Ig-like C2-type 2.				female pregnancy	extracellular region					0		Prostate(69;0.00682)				CAGGACAAGTCGAGGTTCTCT	0.448			NA											40	138					0	0	0.007835	0	0
PSG11	5680	broad.mit.edu	37	19	43519523	43519523	+	Splice_Site	SNP	C	C	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr19:43519523C>T	uc002ovm.1	-	4	817	c.710_splice	c.e4-1	p.H237_splice	PSG11_uc002ouw.2_Intron|PSG10_uc002ouv.1_Intron|PSG6_uc002ovh.1_Intron|PSG6_uc002ovi.2_Intron|PSG6_uc010xwk.1_Intron|PSG11_uc002ovk.1_Intron|PSG11_uc002ovn.1_Splice_Site_p.H243_splice|PSG11_uc002ovo.1_Splice_Site_p.H115_splice|PSG11_uc002ovp.1_Splice_Site_p.H115_splice	NM_002785	NP_002776	Q9UQ72	PSG11_HUMAN	pregnancy specific beta-1-glycoprotein 11						female pregnancy	extracellular region					0		Prostate(69;0.00682)				TCTGGACCATCTGGAGGAAAG	0.502			NA											33	129					0	0	0.009718	0	0
PSG4	5672	broad.mit.edu	37	19	43708260	43708260	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr19:43708260C>A	uc002ovy.2	-	2	310	c.208G>T	c.(208-210)GGG>TGG	p.G70W	PSG4_uc002owa.2_RNA|PSG4_uc002owb.2_Missense_Mutation_p.G70W|PSG4_uc002ovz.2_Missense_Mutation_p.G70W	NM_002780	NP_002771	Q00888	PSG4_HUMAN	pregnancy specific beta-1-glycoprotein 4 isoform	70	Ig-like V-type.				defense response|female pregnancy	extracellular region				ovary(1)	1		Prostate(69;0.00682)				GTCATTTGCCCTTTGTACCAA	0.423			NA											109	113					1.51877e-38	2.77105e-38	0.00361	1	0
ZNF230	7773	broad.mit.edu	37	19	44514466	44514466	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr19:44514466G>T	uc002oyb.1	+	5	526	c.275G>T	c.(274-276)TGC>TTC	p.C92F		NM_006300	NP_006291	Q9UIE0	ZN230_HUMAN	zinc finger protein 230	92	KRNB.			C -> V (in Ref. 1; AAB62180).	regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Prostate(69;0.0352)				GACTGCCCTTGCCAGCAAATC	0.453	GBM(175;914 2069 22996 47111 52600)		NA											16	54					1.01871e-10	1.42505e-10	0.008871	1	0
ZNF223	7766	broad.mit.edu	37	19	44570392	44570392	+	Silent	SNP	A	A	G			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr19:44570392A>G	uc002oyf.1	+	5	664	c.411A>G	c.(409-411)GGA>GGG	p.G137G	ZNF284_uc010ejd.2_RNA	NM_013361	NP_037493	Q9UK11	ZN223_HUMAN	zinc finger protein 223	137					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Prostate(69;0.0352)				TTGAGGAAGGACTATCTATAA	0.438			NA											22	66					0	0	0.001882	0	0
ZFP112	7771	broad.mit.edu	37	19	44833074	44833074	+	Silent	SNP	T	T	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr19:44833074T>A	uc010ejj.2	-	5	1367	c.1254A>T	c.(1252-1254)ATA>ATT	p.I418I	ZFP112_uc002ozc.3_Silent_p.I412I|ZFP112_uc010xwy.1_Silent_p.I435I|ZFP112_uc010xwz.1_Silent_p.I417I	NM_001083335	NP_001076804	Q9UJU3	ZF112_HUMAN	zinc finger protein 228 isoform 1	418					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)|skin(2)	5						TTCCATACTCTATATCTGTGT	0.348	Melanoma(53;975 1202 7512 15993 27273)		NA											20	65					0	0	0.002299	0	0
ZNF180	7733	broad.mit.edu	37	19	44980970	44980970	+	Silent	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr19:44980970C>A	uc002ozf.3	-	5	2010	c.1728G>T	c.(1726-1728)CCG>CCT	p.P576P	ZNF180_uc002ozh.3_Silent_p.P233P|ZNF180_uc002ozi.3_Silent_p.P549P|ZNF180_uc002ozg.3_Silent_p.P575P|ZNF180_uc010ejm.2_Silent_p.P551P	NM_013256	NP_037388	Q9UJW8	ZN180_HUMAN	zinc finger protein 180	576					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.P576L(1)		ovary(2)	2		Prostate(69;0.0435)				TACATTCATACGGTTTTTCCC	0.403	Esophageal Squamous(180;1353 2003 32862 46574 49854)		NA											49	70					2.48909e-17	4.00571e-17	0.00361	1	0
APOC1	341	broad.mit.edu	37	19	45419582	45419583	+	Splice_Site	DNP	GG	GG	TT			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr19:45419582_45419583GG>TT	uc002pac.1	+	4	446	c.194_splice	c.e4+1	p.R65_splice	APOC1_uc002pad.1_Splice_Site_p.R65_splice|APOC1_uc002pae.1_Splice_Site_p.R65_splice|APOC1_uc002paf.1_Splice_Site	NM_001645	NP_001636	P02654	APOC1_HUMAN	apolipoprotein C-I precursor						cholesterol efflux|chylomicron remnant clearance|high-density lipoprotein particle remodeling|lipoprotein metabolic process|negative regulation of cholesterol transport|negative regulation of fatty acid biosynthetic process|negative regulation of lipoprotein lipase activity|negative regulation of phosphatidylcholine catabolic process|negative regulation of receptor-mediated endocytosis|negative regulation of very-low-density lipoprotein particle clearance|phospholipid efflux|positive regulation of cholesterol esterification|very-low-density lipoprotein particle assembly|very-low-density lipoprotein particle clearance	chylomicron|endoplasmic reticulum|high-density lipoprotein particle|very-low-density lipoprotein particle	fatty acid binding|phosphatidylcholine binding|phosphatidylcholine-sterol O-acyltransferase activator activity|phospholipase inhibitor activity				0	Lung NSC(12;0.0018)|all_lung(12;0.00481)	Ovarian(192;0.0728)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.00327)|Epithelial(262;0.174)		GCCAAGATGCGGTTAGAACCCT	0.51			NA											21	70					0	0	0.004672	0	0
PPP1R13L	10848	broad.mit.edu	37	19	45885899	45885900	+	Missense_Mutation	DNP	GG	GG	AC			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr19:45885899_45885900GG>AC	uc002pbn.2	-	12	2410_2411	c.2333_2334CC>GT	c.(2332-2334)TCC>TGT	p.S778C	PPP1R13L_uc002pbm.2_Missense_Mutation_p.S357C|PPP1R13L_uc002pbo.2_Missense_Mutation_p.S778C	NM_006663	NP_006654	Q8WUF5	IASPP_HUMAN	protein phosphatase 1, regulatory subunit 13	778	SH3.				apoptosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	transcription corepressor activity|transcription factor binding			skin(1)	1		all_neural(266;0.224)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.0182)		CCTCGCGGAAGGACAGCTCGTC	0.683	Pancreas(61;1447 1663 31419 50578)		NA											22	53					0	0	0.004672	0	0
GPR4	2828	broad.mit.edu	37	19	46094935	46094935	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr19:46094935G>C	uc002pcm.2	-	2	1135	c.190C>G	c.(190-192)CTG>GTG	p.L64V	OPA3_uc010xxk.1_Intron	NM_005282	NP_005273	P46093	GPR4_HUMAN	G protein-coupled receptor 4	64	Helical; Name=2; (Potential).					integral to plasma membrane	G-protein coupled receptor activity			ovary(2)	2				OV - Ovarian serous cystadenocarcinoma(262;0.0071)|GBM - Glioblastoma multiforme(486;0.128)|Epithelial(262;0.223)		ATGTACAGCAGGTCGGCGATG	0.632	Esophageal Squamous(117;181 1612 1673 14956 42937)		NA											20	97					0	0	0.001882	0	0
HIF3A	64344	broad.mit.edu	37	19	46832479	46832479	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr19:46832479G>T	uc002peh.2	+	12	1485	c.1456G>T	c.(1456-1458)GAT>TAT	p.D486Y	HIF3A_uc002peg.3_Missense_Mutation_p.D486Y|HIF3A_uc002pei.3_Missense_Mutation_p.D430Y|HIF3A_uc002pej.1_Intron|HIF3A_uc002pek.2_Missense_Mutation_p.D430Y|HIF3A_uc010xxy.1_Missense_Mutation_p.D417Y|HIF3A_uc002pel.2_Missense_Mutation_p.D484Y|HIF3A_uc010xxz.1_Missense_Mutation_p.D435Y	NM_152795	NP_690008	Q9Y2N7	HIF3A_HUMAN	hypoxia inducible factor 3, alpha subunit	486	NTAD.|ODD.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|signal transducer activity			upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	3		Ovarian(192;0.00965)|all_neural(266;0.0887)		OV - Ovarian serous cystadenocarcinoma(262;0.00204)|all cancers(93;0.0107)|GBM - Glioblastoma multiforme(486;0.0489)|Epithelial(262;0.136)		TGATGCTCTGGATTTGGAGAT	0.408			NA											31	93					4.4194e-11	6.26468e-11	0.002836	1	0
CALM3	808	broad.mit.edu	37	19	47112165	47112165	+	Silent	SNP	G	G	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr19:47112165G>A	uc002pew.2	+	5	528	c.348G>A	c.(346-348)AAG>AAA	p.K116K	CALM3_uc010ekp.2_Silent_p.K80K|CALM3_uc010xyc.1_Silent_p.K116K	NM_005184	NP_005175	P62158	CALM_HUMAN	calmodulin 3	116	EF-hand 3.				activation of phospholipase C activity|G-protein coupled receptor protein signaling pathway|glucose metabolic process|glycogen catabolic process|muscle contraction|negative regulation of ryanodine-sensitive calcium-release channel activity|nerve growth factor receptor signaling pathway|nitric oxide metabolic process|platelet activation|platelet degranulation|positive regulation of ryanodine-sensitive calcium-release channel activity|regulation of cytokinesis|regulation of nitric-oxide synthase activity|regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to calcium ion|synaptic transmission	centrosome|cytosol|extracellular region|nucleoplasm|plasma membrane|spindle microtubule|spindle pole	calcium ion binding|N-terminal myristoylation domain binding|phospholipase binding|protein domain specific binding|thioesterase binding|titin binding			ovary(1)	1		Ovarian(192;0.0129)|all_neural(266;0.0459)|Breast(70;0.212)		OV - Ovarian serous cystadenocarcinoma(262;0.000338)|all cancers(93;0.000683)|Epithelial(262;0.0181)|GBM - Glioblastoma multiforme(486;0.0341)	Aprindine(DB01429)|Bepridil(DB01244)|Dibucaine(DB00527)|Felodipine(DB01023)|Flunarizine(DB04841)|Fluphenazine(DB00623)|Isoflurane(DB00753)|Loperamide(DB00836)|Miconazole(DB01110)|Perphenazine(DB00850)|Phenoxybenzamine(DB00925)|Pimozide(DB01100)|Promethazine(DB01069)	TGGGGGAGAAGCTGACCGATG	0.552			NA											19	31					0	0	0.002299	0	0
LMTK3	114783	broad.mit.edu	37	19	49005745	49005745	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr19:49005745C>G	uc002pjk.2	-	8	826	c.826G>C	c.(826-828)GGC>CGC	p.G276R		NM_001080434	NP_001073903			lemur tyrosine kinase 3											lung(5)|central_nervous_system(1)	6		all_lung(116;0.000147)|Lung NSC(112;0.000251)|all_epithelial(76;0.000326)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000114)|all cancers(93;0.000141)|Epithelial(262;0.00854)|GBM - Glioblastoma multiforme(486;0.0231)		ATCTCCAGGCCCATCCTCTGC	0.711			NA											7	60					0	0	0.004482	0	0
FUT1	2523	broad.mit.edu	37	19	49253552	49253552	+	Silent	SNP	G	G	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr19:49253552G>A	uc002pkk.2	-	4	1962	c.987C>T	c.(985-987)ACC>ACT	p.T329T		NM_000148	NP_000139	P19526	FUT1_HUMAN	fucosyltransferase 1	329	Lumenal (Potential).				L-fucose catabolic process|protein glycosylation	Golgi cisterna membrane|integral to plasma membrane|membrane fraction	galactoside 2-alpha-L-fucosyltransferase activity			ovary(1)	1		all_lung(116;1.7e-06)|all_epithelial(76;3.52e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.000135)|all cancers(93;0.000354)|Epithelial(262;0.0191)|GBM - Glioblastoma multiforme(486;0.0222)		AGTCTGGCAGGGTGAAGTTGG	0.567			NA											17	7					0	0	0.008871	0	0
TBC1D17	79735	broad.mit.edu	37	19	50391574	50391574	+	Silent	SNP	C	C	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr19:50391574C>T	uc002pqo.2	+	16	1898	c.1746C>T	c.(1744-1746)CCC>CCT	p.P582P	TBC1D17_uc010ybg.1_Silent_p.P549P|TBC1D17_uc002pqp.2_Silent_p.P233P|TBC1D17_uc002pqr.2_Silent_p.P233P|TBC1D17_uc002pqs.2_RNA|IL4I1_uc002pqv.1_3'UTR|IL4I1_uc010eno.1_3'UTR|IL4I1_uc002pqw.1_3'UTR	NM_024682	NP_078958	Q9HA65	TBC17_HUMAN	TBC1 domain family, member 17	582						intracellular	Rab GTPase activator activity				0		all_lung(116;0.000338)|Lung NSC(112;0.000446)|all_neural(266;0.107)|Ovarian(192;0.231)		GBM - Glioblastoma multiforme(134;0.0116)|OV - Ovarian serous cystadenocarcinoma(262;0.017)		CCGCCTGCCCCGTGAGTCCCC	0.697			NA											6	7					0	0	0.001168	0	0
ZNF473	25888	broad.mit.edu	37	19	50542426	50542426	+	Silent	SNP	G	G	C			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr19:50542426G>C	uc002prn.2	+	3	255	c.18G>C	c.(16-18)GTG>GTC	p.V6V	ZNF473_uc002prm.2_Silent_p.V6V|ZNF473_uc010ybo.1_5'UTR	NM_001006656	NP_001006657	Q8WTR7	ZN473_HUMAN	zinc finger protein 473	6	KRAB.				histone mRNA 3'-end processing|regulation of transcription, DNA-dependent|termination of RNA polymerase II transcription	Cajal body	DNA binding|protein binding|zinc ion binding			ovary(1)|central_nervous_system(1)	2		all_neural(266;0.0459)|Ovarian(192;0.0728)		GBM - Glioblastoma multiforme(134;0.00111)|OV - Ovarian serous cystadenocarcinoma(262;0.0058)		AGGAATTTGTGACCCTCAAGG	0.577			NA											85	53					0	0	0.00361	0	0
NAPSA	9476	broad.mit.edu	37	19	50868854	50868854	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr19:50868854G>A	uc002prx.2	-	1	78	c.25C>T	c.(25-27)CCC>TCC	p.P9S	NR1H2_uc002prv.3_Intron	NM_004851	NP_004842	O96009	NAPSA_HUMAN	napsin A preproprotein	9					proteolysis	extracellular region	aspartic-type endopeptidase activity				0		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00743)|GBM - Glioblastoma multiforme(134;0.0183)		agcagcaggggttgcagcagc	0.468			NA											12	8					0	0	0.000978	0	0
SYT3	84258	broad.mit.edu	37	19	51140624	51140624	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr19:51140624G>C	uc002pst.2	-	1	679	c.45C>G	c.(43-45)ATC>ATG	p.I15M	SYT3_uc002psv.2_Missense_Mutation_p.I15M|SYT3_uc010ycd.1_Missense_Mutation_p.I15M	NM_032298	NP_115674	Q9BQG1	SYT3_HUMAN	synaptotagmin III	15	Vesicular (Potential).					cell junction|endosome|integral to membrane|synaptic vesicle membrane	metal ion binding|transporter activity			ovary(2)|breast(1)	3		all_neural(266;0.131)		OV - Ovarian serous cystadenocarcinoma(262;0.00462)|GBM - Glioblastoma multiforme(134;0.0188)		CCGAGACCAGGATGAGTGCCC	0.622			NA											28	26					0	0	0.007291	0	0
KLK4	9622	broad.mit.edu	37	19	51412616	51412616	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr19:51412616G>A	uc002pua.1	-	2	116	c.116C>T	c.(115-117)CCG>CTG	p.P39L	KLK4_uc002pty.1_5'UTR|KLK4_uc002ptz.1_RNA|KLK4_uc002pub.1_5'UTR|KLK4_uc002puc.1_RNA|KLK4_uc010eoi.1_5'UTR|KLK4_uc002pud.1_5'Flank	NM_004917	NP_004908	Q9Y5K2	KLK4_HUMAN	kallikrein-related peptidase 4 preproprotein	39	Peptidase S1.				proteolysis	extracellular region	metal ion binding|serine-type endopeptidase activity				0		all_neural(266;0.026)		OV - Ovarian serous cystadenocarcinoma(262;0.00624)|GBM - Glioblastoma multiforme(134;0.00878)		CTGCGAGTGCGGGCTGCAGTC	0.637			NA											186	116					0	0	0.00361	0	0
CEACAM18	729767	broad.mit.edu	37	19	51986392	51986392	+	Nonsense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr19:51986392C>A	uc002pwv.1	+	5	978	c.978C>A	c.(976-978)TAC>TAA	p.Y326*		NM_001080405	NP_001073874	A8MTB9	CEA18_HUMAN	carcinoembryonic antigen-related cell adhesion	326	Ig-like C2-type.					integral to membrane				skin(1)	1		all_neural(266;0.0529)		GBM - Glioblastoma multiforme(134;0.00148)|OV - Ovarian serous cystadenocarcinoma(262;0.00979)		ATCTCAAGTACCACTGGATCC	0.512			NA											85	52					1.01459e-35	1.84213e-35	0.00361	1	0
SIGLEC12	89858	broad.mit.edu	37	19	52000636	52000636	+	Missense_Mutation	SNP	A	A	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr19:52000636A>T	uc002pwx.1	-	6	1525	c.1469T>A	c.(1468-1470)CTG>CAG	p.L490Q	SIGLEC12_uc002pww.1_Missense_Mutation_p.L372Q|SIGLEC12_uc010eoy.1_Missense_Mutation_p.L217Q	NM_053003	NP_443729	Q96PQ1	SIG12_HUMAN	sialic acid binding immunoglobulin-like	490	Helical; (Potential).				cell adhesion	integral to membrane	sugar binding			ovary(3)|skin(2)	5		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.00161)|OV - Ovarian serous cystadenocarcinoma(262;0.0102)		CAGGAAGACCAGGGCTGTGGC	0.557			NA											19	53					0	0	0.002852	0	0
SIGLEC5	8778	broad.mit.edu	37	19	52130768	52130768	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr19:52130768C>A	uc002pxe.2	-	6	1368	c.1229G>T	c.(1228-1230)TGC>TTC	p.C410F		NM_003830	NP_003821	O15389	SIGL5_HUMAN	sialic acid binding Ig-like lectin 5 precursor	410	Extracellular (Potential).				cell adhesion	integral to membrane	sugar binding			skin(2)|breast(1)|central_nervous_system(1)	4		all_neural(266;0.0726)		GBM - Glioblastoma multiforme(134;0.00124)|OV - Ovarian serous cystadenocarcinoma(262;0.0218)		CCAGGCCTTGCAGCTGACTTT	0.642			NA											57	49					2.6711e-34	4.81446e-34	0.00361	1	0
ZNF665	79788	broad.mit.edu	37	19	53668496	53668496	+	Missense_Mutation	SNP	T	T	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr19:53668496T>A	uc010eqm.1	-	4	1347	c.1247A>T	c.(1246-1248)CAC>CTC	p.H416L		NM_024733	NP_079009	Q9H7R5	ZN665_HUMAN	zinc finger protein 665	351	C2H2-type 9.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2				GBM - Glioblastoma multiforme(134;0.0196)		ATTTGCTAAGTGTGAATACTG	0.403			NA											38	23					0	0	0.007835	0	0
SYT5	6861	broad.mit.edu	37	19	55686584	55686584	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr19:55686584G>T	uc002qjm.1	-	5	1724	c.664C>A	c.(664-666)CCA>ACA	p.P222T	SYT5_uc002qjp.2_Missense_Mutation_p.P219T|SYT5_uc002qjn.1_Missense_Mutation_p.P222T|SYT5_uc002qjo.1_Missense_Mutation_p.P222T	NM_003180	NP_003171	O00445	SYT5_HUMAN	synaptotagmin V	222	Cytoplasmic (Potential).				energy reserve metabolic process|regulation of insulin secretion|synaptic transmission	cell junction|integral to membrane|recycling endosome membrane|synaptic vesicle membrane	metal ion binding|transporter activity				0			BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0452)		GCCTGCACTGGCCGCCCCAGG	0.716			NA											12	6					9.31168e-06	1.10067e-05	0.001855	1	0
PTPRH	5794	broad.mit.edu	37	19	55693137	55693137	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr19:55693137G>T	uc002qjq.2	-	20	3406	c.3333C>A	c.(3331-3333)CAC>CAA	p.H1111Q	PTPRH_uc010esv.2_Missense_Mutation_p.H933Q|SYT5_uc002qjm.1_5'Flank|SYT5_uc002qjp.2_5'Flank|SYT5_uc002qjn.1_5'Flank|SYT5_uc002qjo.1_5'Flank	NM_002842	NP_002833	Q9HD43	PTPRH_HUMAN	protein tyrosine phosphatase, receptor type, H	1111	Cytoplasmic (Potential).				apoptosis	cytoplasm|integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			ovary(2)|large_intestine(1)|skin(1)	4		Renal(1328;0.245)	BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0479)		CCTCCAACTTGTGGGCCTGGA	0.607			NA											75	48					4.38691e-48	8.13383e-48	0.00361	1	0
RPL28	6158	broad.mit.edu	37	19	55899329	55899329	+	Silent	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr19:55899329G>T	uc002qkv.2	+	4	279	c.237G>T	c.(235-237)CGG>CGT	p.R79R	RPL28_uc010yga.1_Silent_p.R79R|RPL28_uc010ygb.1_Silent_p.R79R|RPL28_uc002qkw.1_3'UTR	NM_000991	NP_000982	P46779	RL28_HUMAN	ribosomal protein L28 isoform 2	79					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit	protein binding|RNA binding|structural constituent of ribosome				0	Breast(117;0.191)	Renal(1328;0.245)	LUSC - Lung squamous cell carcinoma(43;0.13)|BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0443)		CCTATGTGCGGACCACCATCA	0.612			NA											77	61					1.67174e-50	3.11514e-50	0.00361	1	0
NLRP11	204801	broad.mit.edu	37	19	56320389	56320389	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr19:56320389C>T	uc010ygf.1	-	5	2298	c.1587G>A	c.(1585-1587)ATG>ATA	p.M529I	NLRP11_uc002qlz.2_Missense_Mutation_p.M430I|NLRP11_uc002qmb.2_Missense_Mutation_p.M430I|NLRP11_uc002qmc.2_RNA|NLRP11_uc010ete.1_RNA	NM_145007	NP_659444	P59045	NAL11_HUMAN	NLR family, pyrin domain containing 11	529							ATP binding			ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	6		Colorectal(82;0.0002)		GBM - Glioblastoma multiforme(193;0.0325)		CCAAATGTTTCATGTATCCCA	0.438			NA											71	55					0	0	0.00361	0	0
NLRP8	126205	broad.mit.edu	37	19	56467463	56467463	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr19:56467463C>A	uc002qmh.2	+	3	2110	c.2039C>A	c.(2038-2040)TCT>TAT	p.S680Y	NLRP8_uc010etg.2_Missense_Mutation_p.S680Y	NM_176811	NP_789781	Q86W28	NALP8_HUMAN	NLR family, pyrin domain containing 8	680						cytoplasm	ATP binding			ovary(4)|breast(3)|central_nervous_system(2)|skin(2)|large_intestine(1)|kidney(1)	13		Colorectal(82;0.000147)|Ovarian(87;0.17)		GBM - Glioblastoma multiforme(193;0.0695)		CATCCTGGCTCTGAGTAAGTG	0.547			NA											36	32					1.59361e-14	2.43295e-14	0.006999	1	0
NLRP5	126206	broad.mit.edu	37	19	56538657	56538657	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr19:56538657G>T	uc002qmj.2	+	7	1058	c.1058G>T	c.(1057-1059)CGA>CTA	p.R353L	NLRP5_uc002qmi.2_Missense_Mutation_p.R334L	NM_153447	NP_703148	P59047	NALP5_HUMAN	NACHT, LRR and PYD containing protein 5	353	NACHT.					mitochondrion|nucleolus	ATP binding			ovary(3)|skin(2)|kidney(1)|central_nervous_system(1)	7		Colorectal(82;3.46e-05)|Ovarian(87;0.0481)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0326)		ATCATGTCCCGACCAGAAAGG	0.547			NA											6	12					5.9392e-07	7.35353e-07	0.001168	1	0
ZSCAN5B	342933	broad.mit.edu	37	19	56704301	56704301	+	Nonsense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr19:56704301C>A	uc010ygh.1	-	1	121	c.121G>T	c.(121-123)GAG>TAG	p.E41*		NM_001080456	NP_001073925	A6NJL1	ZSA5B_HUMAN	zinc finger and SCAN domain containing 5B	41					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|skin(1)	2						TGCCAAGTCTCAGGGTTCCTG	0.572			NA											14	6					4.36969e-10	6.03318e-10	0.001855	1	0
ZNF583	147949	broad.mit.edu	37	19	56935118	56935118	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr19:56935118G>T	uc010ygl.1	+	5	1256	c.1091G>T	c.(1090-1092)CGT>CTT	p.R364L	ZNF583_uc002qnc.2_Missense_Mutation_p.R364L|ZNF583_uc010ygm.1_Missense_Mutation_p.R364L	NM_001159860	NP_001153332	Q96ND8	ZN583_HUMAN	zinc finger protein 583	364	C2H2-type 6.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Colorectal(82;0.000256)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0564)		TTTAGCCATCGTGGATACCTA	0.423			NA											47	30					1.83081e-24	3.16559e-24	0.00361	1	0
PEG3	5178	broad.mit.edu	37	19	57327159	57327159	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr19:57327159C>A	uc002qnu.2	-	7	3002	c.2651G>T	c.(2650-2652)GGG>GTG	p.G884V	ZIM2_uc010ygq.1_Intron|ZIM2_uc010ygr.1_Intron|ZIM2_uc002qnr.2_Intron|ZIM2_uc002qnq.2_Intron|ZIM2_uc010etp.2_Intron|ZIM2_uc010ygs.1_Intron|PEG3_uc002qnt.2_Missense_Mutation_p.G855V|PEG3_uc002qnv.2_Missense_Mutation_p.G884V|PEG3_uc002qnw.2_Missense_Mutation_p.G760V|PEG3_uc002qnx.2_Missense_Mutation_p.G758V|PEG3_uc010etr.2_Missense_Mutation_p.G884V	NM_001146186	NP_001139658	Q9GZU2	PEG3_HUMAN	paternally expressed 3 isoform 1	884					apoptosis|viral reproduction	cytoplasm|nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0269)		CTTACTGCCCCCTTCACAAGG	0.443			NA											37	27					9.62906e-15	1.47612e-14	0.00623	1	0
ZNF304	57343	broad.mit.edu	37	19	57865133	57865133	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr19:57865133G>T	uc010ygw.1	+	2	462	c.74G>T	c.(73-75)CGG>CTG	p.R25L	ZNF304_uc010etw.2_Missense_Mutation_p.R25L|ZNF304_uc010etx.2_5'UTR	NM_020657	NP_065708	Q9HCX3	ZN304_HUMAN	zinc finger protein 304	25	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.221)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0265)		TACTTCTCTCGGGAGGAGTGG	0.512			NA											42	49					1.48734e-19	2.45468e-19	0.003214	1	0
TMEM18	129787	broad.mit.edu	37	2	675580	675580	+	Silent	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr2:675580C>A	uc002qwl.2	-	2	202	c.108G>T	c.(106-108)GCG>GCT	p.A36A	TMEM18_uc002qwk.2_RNA|uc002qwm.1_5'Flank	NM_152834	NP_690047	Q96B42	TMM18_HUMAN	transmembrane protein 18	36	Helical; (Potential).				cell migration	integral to membrane|nuclear membrane				ovary(1)	1	all_hematologic(175;0.0429)|Acute lymphoblastic leukemia(172;0.0627)	all_cancers(51;5.27e-05)|all_epithelial(98;2.11e-06)|Ovarian(717;0.0253)		all cancers(51;1.95e-21)|Epithelial(75;9.47e-21)|OV - Ovarian serous cystadenocarcinoma(76;8.15e-18)|GBM - Glioblastoma multiforme(21;0.0285)		GCACGCAGAGCGCGTGGAAGG	0.577			NA											25	34					8.58068e-18	1.39296e-17	0.007291	1	0
TPO	7173	broad.mit.edu	37	2	1426896	1426896	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr2:1426896G>A	uc002qww.2	+	3	265	c.174G>A	c.(172-174)ATG>ATA	p.M58I	TPO_uc010ewj.2_Intron|TPO_uc010yin.1_Missense_Mutation_p.M58I|TPO_uc002qwu.2_Missense_Mutation_p.M58I|TPO_uc002qwr.2_Missense_Mutation_p.M58I|TPO_uc002qwx.2_Missense_Mutation_p.M58I|TPO_uc010yio.1_Missense_Mutation_p.M58I|TPO_uc010yip.1_Missense_Mutation_p.M58I	NM_000547	NP_000538	P07202	PERT_HUMAN	thyroid peroxidase isoform a	58	Extracellular (Potential).				cellular nitrogen compound metabolic process|hormone biosynthetic process|hydrogen peroxide catabolic process	cell surface|cytoplasm|integral to plasma membrane	calcium ion binding|heme binding|iodide peroxidase activity			ovary(7)|pancreas(6)|skin(5)|lung(1)|kidney(1)	20	all_hematologic(175;0.0487)|Acute lymphoblastic leukemia(172;0.0627)	all_cancers(51;0.0338)		all cancers(51;0.0356)|OV - Ovarian serous cystadenocarcinoma(76;0.0748)|Epithelial(75;0.12)	Carbimazole(DB00389)|Methimazole(DB00763)|Propylthiouracil(DB00550)	ACGCCACGATGCAGAGGTGAG	0.582			NA											7	21					0	0	0.004482	0	0
KIDINS220	57498	broad.mit.edu	37	2	8870855	8870855	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr2:8870855G>C	uc002qzc.2	-	30	5493	c.5311C>G	c.(5311-5313)CTT>GTT	p.L1771V	KIDINS220_uc010yiv.1_Intron|KIDINS220_uc002qzd.2_Missense_Mutation_p.L1672V|KIDINS220_uc002qzb.2_Missense_Mutation_p.L625V	NM_020738	NP_065789	Q9ULH0	KDIS_HUMAN	kinase D-interacting substrate of 220 kDa	1771	Mediates interaction with SNTA1 (By similarity).|Cytoplasmic (Potential).				activation of MAPKK activity|nerve growth factor receptor signaling pathway	cytosol|integral to membrane				ovary(3)|central_nervous_system(1)	4	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)					TTTTCTCAAAGAATGCTTTCT	0.448			NA											10	28					0	0	0.008291	0	0
KCNF1	3754	broad.mit.edu	37	2	11053234	11053234	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr2:11053234G>T	uc002rax.2	+	1	1172	c.682G>T	c.(682-684)GCG>TCG	p.A228S		NM_002236	NP_002227	Q9H3M0	KCNF1_HUMAN	potassium voltage-gated channel, subfamily F,	228	Helical; Name=Segment S2; (Potential).					voltage-gated potassium channel complex	voltage-gated potassium channel activity			ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.191)			Epithelial(75;0.115)|OV - Ovarian serous cystadenocarcinoma(76;0.128)		CGTGGAGACGGCGTGCATTGG	0.627			NA											19	46					1.15919e-05	1.35939e-05	0.008871	1	0
TRIB2	28951	broad.mit.edu	37	2	12880753	12880753	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr2:12880753C>G	uc002rbv.3	+	3	2301	c.865C>G	c.(865-867)CTG>GTG	p.L289V	TRIB2_uc010yjp.1_Missense_Mutation_p.L153V	NM_021643	NP_067675	Q92519	TRIB2_HUMAN	tribbles homolog 2	289	Protein kinase.				negative regulation of fat cell differentiation|negative regulation of interleukin-10 biosynthetic process|negative regulation of protein kinase activity|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|regulation of MAP kinase activity	cytoplasm|cytoskeleton|nucleus	ATP binding|protein kinase activity|protein kinase inhibitor activity|transcription factor binding|ubiquitin protein ligase binding|ubiquitin-protein ligase regulator activity			stomach(1)	1	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)					CCGAAGCATTCTGCGTCGGGA	0.532			NA											21	21					0	0	0.003954	0	0
NBAS	51594	broad.mit.edu	37	2	15644305	15644305	+	Missense_Mutation	SNP	T	T	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr2:15644305T>A	uc002rcc.1	-	11	944	c.918A>T	c.(916-918)TTA>TTT	p.L306F	NBAS_uc002rcd.1_RNA	NM_015909	NP_056993	A2RRP1	NBAS_HUMAN	neuroblastoma-amplified protein	306										ovary(2)|liver(1)|skin(1)	4						ACTTGACACTTAACATCCTTA	0.303			NA											18	54					0	0	0.010504	0	0
APOB	338	broad.mit.edu	37	2	21233628	21233628	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr2:21233628C>T	uc002red.2	-	26	6240	c.6112G>A	c.(6112-6114)GAT>AAT	p.D2038N		NM_000384	NP_000375	P04114	APOB_HUMAN	apolipoprotein B precursor	2038					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			ovary(11)|skin(9)|central_nervous_system(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	TCTAAAGCATCAATGATATTG	0.408			NA											36	70					0	0	0.007835	0	0
UBXN2A	165324	broad.mit.edu	37	2	24222692	24222692	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr2:24222692G>C	uc010exy.2	+	8	1203	c.735G>C	c.(733-735)CAG>CAC	p.Q245H	UBXN2A_uc002rem.2_RNA|UBXN2A_uc002ren.2_Missense_Mutation_p.Q245H|UBXN2A_uc010ykj.1_Missense_Mutation_p.Q192H	NM_181713	NP_859064	P68543	UBX2A_HUMAN	UBX domain containing 4	245	UBX.										0						TCATCATTCAGAGACTCCAAA	0.418			NA											30	39					0	0	0.002445	0	0
MFSD2B	388931	broad.mit.edu	37	2	24239823	24239823	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr2:24239823C>G	uc002reo.1	+	4	470	c.456C>G	c.(454-456)TTC>TTG	p.F152L	MFSD2B_uc010exz.1_RNA	NM_001080473	NP_001073942	A6NFX1	MFS2B_HUMAN	major facilitator superfamily domain containing	152	Helical; (Potential).				transport	integral to membrane				ovary(2)	2						ACTGCCTGTTCCAGGCCCTGG	0.647			NA											26	31					0	0	0.002445	0	0
ITSN2	50618	broad.mit.edu	37	2	24516556	24516556	+	Splice_Site	SNP	C	C	G			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr2:24516556C>G	uc002rfe.2	-	15	1981	c.1723_splice	c.e15+1	p.D575_splice	ITSN2_uc002rff.2_Splice_Site_p.D575_splice|ITSN2_uc002rfg.2_Splice_Site_p.D575_splice|ITSN2_uc010eyd.2_Splice_Site_p.D600_splice	NM_006277	NP_006268	Q9NZM3	ITSN2_HUMAN	intersectin 2 isoform 1						endocytosis|regulation of Rho protein signal transduction	cytoplasm	calcium ion binding|Rho guanyl-nucleotide exchange factor activity|SH3/SH2 adaptor activity			kidney(2)|ovary(1)|central_nervous_system(1)	4	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TAGAGACTTACCAGGTGTGTT	0.279			NA											5	34					0	0	0.000602	0	0
NCOA1	8648	broad.mit.edu	37	2	24933855	24933855	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr2:24933855C>T	uc002rfk.2	+	12	2732	c.2474C>T	c.(2473-2475)GCA>GTA	p.A825V	NCOA1_uc010eye.2_Missense_Mutation_p.A825V|NCOA1_uc002rfi.2_Missense_Mutation_p.A674V|NCOA1_uc002rfj.2_Missense_Mutation_p.A825V|NCOA1_uc002rfl.2_Missense_Mutation_p.A825V	NM_003743	NP_003734	Q15788	NCOA1_HUMAN	nuclear receptor coactivator 1 isoform 1	825	Interaction with CREBBP.								PAX3/NCOA1(8)	soft_tissue(8)|ovary(1)|lung(1)|skin(1)	11	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GAGAAGGCAGCACAGTTGCCA	0.473			NA	T	PAX3	alveolar rhadomyosarcoma								20	60					0	0	0.010504	0	0
ADCY3	109	broad.mit.edu	37	2	25061491	25061491	+	Silent	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr2:25061491C>A	uc002rfs.3	-	7	1555	c.1356G>T	c.(1354-1356)GGG>GGT	p.G452G	ADCY3_uc002rfr.3_Missense_Mutation_p.E85D|ADCY3_uc010ykm.1_Silent_p.G452G	NM_004036	NP_004027	O60266	ADCY3_HUMAN	adenylate cyclase 3	452	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|sensory perception of smell|synaptic transmission|transmembrane transport|water transport	cytoplasm|integral to plasma membrane	ATP binding|calmodulin binding|metal ion binding			breast(3)|ovary(1)	4	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.203)					TGTGCACGCGCCTGGATTGCA	0.647			NA											44	76					5.2432e-18	8.53024e-18	0.00361	1	0
HADHA	3030	broad.mit.edu	37	2	26426983	26426983	+	Missense_Mutation	SNP	T	T	C			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr2:26426983T>C	uc002rgy.2	-	12	1298	c.1168A>G	c.(1168-1170)AAA>GAA	p.K390E	HADHA_uc010yks.1_Missense_Mutation_p.K303E	NM_000182	NP_000173	P40939	ECHA_HUMAN	mitochondrial trifunctional protein, alpha	390					fatty acid beta-oxidation	fatty acid beta-oxidation multienzyme complex|mitochondrial nucleoid|nucleolus	3-hydroxyacyl-CoA dehydrogenase activity|acetyl-CoA C-acetyltransferase activity|coenzyme binding|enoyl-CoA hydratase activity|long-chain-3-hydroxyacyl-CoA dehydrogenase activity|protein binding			ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				NADH(DB00157)	GTGGCATCTTTAAGTATAGTC	0.502			NA											162	264					0	0	0.00361	0	0
KCNK3	3777	broad.mit.edu	37	2	26915939	26915939	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr2:26915939G>T	uc002rhn.2	+	1	359	c.196G>T	c.(196-198)GTG>TTG	p.V66L		NM_002246	NP_002237	O14649	KCNK3_HUMAN	potassium channel, subfamily K, member 3	66					synaptic transmission	integral to plasma membrane				ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GGAGCGCGTCGTGCTGCGCCT	0.697	GBM(80;1457 1631 27100 45946)		NA											12	16					3.07112e-06	3.69777e-06	0.000978	1	0
C2orf18	54978	broad.mit.edu	37	2	26997191	26997191	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr2:26997191G>T	uc002rhp.1	+	2	226	c.150G>T	c.(148-150)CAG>CAT	p.Q50H	C2orf18_uc002rhq.1_Missense_Mutation_p.A25S|C2orf18_uc010eyo.1_Intron|C2orf18_uc010ylc.1_Intron	NM_017877	NP_060347	Q8N357	CB018_HUMAN	ANT2-binding protein precursor	50	Helical; (Potential).					integral to membrane|lysosomal membrane					0	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CCTTCCTCCAGGTATCTGGCC	0.627			NA											10	44					6.40141e-05	7.28859e-05	0.000978	1	0
PLB1	151056	broad.mit.edu	37	2	28812885	28812885	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr2:28812885G>T	uc002rmb.1	+	29	2030	c.2030G>T	c.(2029-2031)GGC>GTC	p.G677V	PLB1_uc010ezj.1_Missense_Mutation_p.G666V|PLB1_uc002rmc.2_Missense_Mutation_p.G365V|PLB1_uc002rmd.1_Missense_Mutation_p.G187V	NM_153021	NP_694566	Q6P1J6	PLB1_HUMAN	phospholipase B1 precursor	677	4 X 308-326 AA approximate repeats.|2.|Extracellular (Potential).				lipid catabolic process|retinoid metabolic process|steroid metabolic process	apical plasma membrane|integral to membrane	lysophospholipase activity|phospholipase A2 activity|retinyl-palmitate esterase activity			ovary(4)|large_intestine(2)|skin(2)|breast(1)	9	Acute lymphoblastic leukemia(172;0.155)					GAGCCTGTTGGCCAGAAGACG	0.552			NA											33	72					2.6416e-12	3.88532e-12	0.00623	1	0
ALK	238	broad.mit.edu	37	2	29443644	29443644	+	Silent	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr2:29443644G>T	uc002rmy.2	-	23	4480	c.3573C>A	c.(3571-3573)CCC>CCA	p.P1191P	ALK_uc010ymo.1_Silent_p.P123P	NM_004304	NP_004295	Q9UM73	ALK_HUMAN	anaplastic lymphoma kinase precursor	1191	Protein kinase.|Cytoplasmic (Potential).				protein autophosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity		NPM1/ALK(632)|EML4/ALK(246)|CLTC/ALK(44)|TPM3/ALK(33)|ATIC/ALK(24)|RANBP2/ALK(16)|TPM4/ALK(12)|TFG/ALK(7)|MSN/ALK(6)|CARS/ALK(5)|VCL/ALK(4)|KIF5B/ALK(4)|PPFIBP1/ALK(3)|SEC31A/ALK(3)|SQSTM1/ALK(2)	haematopoietic_and_lymphoid_tissue(726)|lung(262)|autonomic_ganglia(148)|soft_tissue(61)|breast(4)|kidney(4)|large_intestine(3)|skin(3)|ovary(3)|thyroid(2)|central_nervous_system(1)|pancreas(1)	1218	Acute lymphoblastic leukemia(172;0.155)				Adenosine triphosphate(DB00171)	GGATGAACCGGGGCAGGGATT	0.567			NA	T|Mis|A	NPM1|TPM3|TFG|TPM4|ATIC|CLTC|MSN|ALO17|CARS|EML4	ALCL|NSCLC|Neuroblastoma	neuroblastoma			Neuroblastoma_Familial_Clustering_of|Congenital_Central_Hypoventilation_Syndrome				6	34					0.00448238	0.00476433	0.004482	1	0
NLRC4	58484	broad.mit.edu	37	2	32477568	32477568	+	Missense_Mutation	SNP	T	T	C			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr2:32477568T>C	uc002roi.2	-	3	428	c.182A>G	c.(181-183)AAG>AGG	p.K61R	NLRC4_uc002roj.1_Missense_Mutation_p.K61R|NLRC4_uc010ezt.1_Missense_Mutation_p.K61R	NM_021209	NP_067032	Q9NPP4	NLRC4_HUMAN	caspase recruitment domain protein 12	61	CARD.				activation of caspase activity|defense response to bacterium|detection of bacterium|interleukin-1 beta secretion|positive regulation of apoptosis	cytoplasm	ATP binding|magnesium ion binding|protein homodimerization activity			ovary(3)|large_intestine(1)|lung(1)|skin(1)	6	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.208)					CTCTGAACCCTTTTTCAAAAT	0.398			NA											3	119					0	0	0.000602	0	0
HEATR5B	54497	broad.mit.edu	37	2	37208830	37208830	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr2:37208830G>C	uc002rpp.1	-	36	6115	c.6019C>G	c.(6019-6021)CTC>GTC	p.L2007V	HEATR5B_uc002rpo.1_Missense_Mutation_p.L319V|HEATR5B_uc010ezy.1_Missense_Mutation_p.L502V	NM_019024	NP_061897	Q9P2D3	HTR5B_HUMAN	HEAT repeat containing 5B	2007							binding			ovary(5)|skin(2)|breast(1)	8		all_hematologic(82;0.21)				AAATTCTGGAGTGCAAACTCA	0.433			NA											18	61					0	0	0.008871	0	0
CDKL4	344387	broad.mit.edu	37	2	39411789	39411789	+	Splice_Site	SNP	C	C	G			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr2:39411789C>G	uc002rrm.2	-	7	736	c.736_splice	c.e7-1	p.E246_splice	CDKL4_uc010fal.1_Splice_Site_p.E246_splice	NM_001009565	NP_001009565	Q5MAI5	CDKL4_HUMAN	cyclin-dependent kinase-like 4							cytoplasm	ATP binding|cyclin-dependent protein kinase activity			ovary(1)	1		all_hematologic(82;0.248)				CAAGAGTTTCCTGAAAAACAA	0.219			NA											5	18					0	0	0.001168	0	0
EML4	27436	broad.mit.edu	37	2	42522520	42522520	+	Splice_Site	SNP	G	G	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr2:42522520G>A	uc002rsi.2	+	13	1616	c.1354_splice	c.e13-1	p.K452_splice	EML4_uc010fap.2_Splice_Site_p.K394_splice|EML4_uc002rsj.2_Splice_Site_p.K141_splice	NM_019063	NP_061936	Q9HC35	EMAL4_HUMAN	echinoderm microtubule associated protein like 4						microtubule-based process|mitosis	cytoplasm|microtubule	protein binding		EML4/ALK(246)	lung(246)|ovary(2)|central_nervous_system(1)|skin(1)	250						TTTCCTTGTAGAAATATGAAA	0.318			NA	T	ALK	NSCLC								29	59					0	0	0.003755	0	0
ABCG8	64241	broad.mit.edu	37	2	44079786	44079786	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr2:44079786C>G	uc002rtq.2	+	6	833	c.743C>G	c.(742-744)GCC>GGC	p.A248G	ABCG8_uc010yoa.1_Missense_Mutation_p.A248G	NM_022437	NP_071882	Q9H221	ABCG8_HUMAN	ATP-binding cassette sub-family G member 8	248	ABC transporter.|Cytoplasmic (Potential).				cholesterol efflux|cholesterol homeostasis|excretion|lipid metabolic process|negative regulation of intestinal cholesterol absorption|negative regulation of intestinal phytosterol absorption	apical plasma membrane|integral to membrane	ATP binding|ATPase activity|protein heterodimerization activity			skin(3)|ovary(1)	4		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)				AGCTTCACAGCCCACAACCTG	0.582			NA											31	66					0	0	0.003755	0	0
SOCS5	9655	broad.mit.edu	37	2	46986074	46986074	+	Silent	SNP	A	A	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr2:46986074A>T	uc002rvf.2	+	2	569	c.405A>T	c.(403-405)TCA>TCT	p.S135S	SOCS5_uc010yoe.1_Silent_p.S104S|SOCS5_uc002rvg.2_Silent_p.S135S	NM_014011	NP_054730	O75159	SOCS5_HUMAN	suppressor of cytokine signaling 5	135					cell growth|cytokine-mediated signaling pathway|intracellular signal transduction|negative regulation of signal transduction|negative regulation of T-helper 2 cell differentiation|positive regulation of T-helper 1 cell differentiation|regulation of growth					ovary(1)|lung(1)|central_nervous_system(1)	3		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)	LUSC - Lung squamous cell carcinoma(58;0.114)			CCCAGAGTTCATTGGATGCTG	0.463			NA											14	26					0	0	0.00499	0	0
FBXO11	80204	broad.mit.edu	37	2	48050495	48050495	+	Missense_Mutation	SNP	T	T	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr2:48050495T>A	uc010fbl.2	-	12	1265	c.1151A>T	c.(1150-1152)TAC>TTC	p.Y384F	FBXO11_uc002rwe.2_Missense_Mutation_p.Y384F|FBXO11_uc002rwf.2_Missense_Mutation_p.Y384F|FBXO11_uc002rwg.1_Missense_Mutation_p.Y384F|FBXO11_uc010fbk.2_5'UTR	NM_025133	NP_079409	Q86XK2	FBX11_HUMAN	F-box only protein 11 isoform 1	468	PbH1 4.				ubiquitin-dependent protein catabolic process	cytoplasm|nucleolus|ubiquitin ligase complex	protein binding|protein-arginine N-methyltransferase activity|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|lung(1)	2		Acute lymphoblastic leukemia(82;0.0299)|all_hematologic(82;0.0358)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)			ACTTTCAAAGTAACCCTGAAA	0.328			NA											5	4					0	0	0.000602	0	0
NRXN1	9378	broad.mit.edu	37	2	50850559	50850560	+	Missense_Mutation	DNP	CC	CC	AA			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr2:50850559_50850560CC>AA	uc010fbq.2	-	6	2602_2603	c.1125_1126GG>TT	c.(1123-1128)CTGGTC>CTTTTC	p.V376F	NRXN1_uc002rxb.3_Missense_Mutation_p.V23F|NRXN1_uc002rxe.3_Missense_Mutation_p.V343F|NRXN1_uc002rxc.1_RNA	NM_001135659	NP_001129131	P58400	NRX1B_HUMAN	neurexin 1 isoform alpha2 precursor	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					angiogenesis|neuron cell-cell adhesion|neuronal signal transduction	cell surface|endocytic vesicle|integral to membrane|presynaptic membrane	cell adhesion molecule binding|receptor binding			ovary(2)	2		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.192)	Lung(47;0.0813)|LUSC - Lung squamous cell carcinoma(58;0.116)			AAATTAATGACCAGAGAGACAG	0.441			NA											36	75					0	0	0.004672	0	0
SPTBN1	6711	broad.mit.edu	37	2	54873410	54873410	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr2:54873410G>C	uc002rxu.2	+	23	4913	c.4664G>C	c.(4663-4665)AGC>ACC	p.S1555T	SPTBN1_uc002rxx.2_Missense_Mutation_p.S1542T	NM_003128	NP_003119	Q01082	SPTB2_HUMAN	spectrin, beta, non-erythrocytic 1 isoform 1	1555	Spectrin 12.				actin filament capping|axon guidance	cytosol|nucleolus|plasma membrane|sarcomere|spectrin	actin binding|calmodulin binding|protein binding|structural constituent of cytoskeleton			ovary(3)|breast(2)|central_nervous_system(2)|skin(1)	8			Lung(47;0.24)			GTCACTGACAGCAGCAGCCTC	0.572			NA											18	72					0	0	0.00499	0	0
EFEMP1	2202	broad.mit.edu	37	2	56104957	56104957	+	Silent	SNP	G	G	A	rs139930646		TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr2:56104957G>A	uc002rzh.2	-	6	1014	c.684C>T	c.(682-684)TGC>TGT	p.C228C	EFEMP1_uc002rzi.2_Silent_p.C228C|EFEMP1_uc002rzj.2_Silent_p.C228C|EFEMP1_uc010ypc.1_Intron	NM_004105	NP_004096	Q12805	FBLN3_HUMAN	EGF-containing fibulin-like extracellular matrix	228	EGF-like 3; calcium-binding (Potential).				negative regulation of chondrocyte differentiation|peptidyl-tyrosine phosphorylation|regulation of transcription, DNA-dependent|visual perception	extracellular space|proteinaceous extracellular matrix	calcium ion binding|epidermal growth factor receptor activity|epidermal growth factor receptor binding|growth factor activity			ovary(4)|pancreas(1)|skin(1)	6			LUSC - Lung squamous cell carcinoma(58;0.127)|Lung(47;0.132)			GTGTATTCACGCATCTTTGGT	0.423	GBM(92;934 1319 7714 28760 40110)		NA											55	132					0	0	0.00361	0	0
ARHGAP25	9938	broad.mit.edu	37	2	69002507	69002507	+	Silent	SNP	G	G	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr2:69002507G>A	uc002seu.2	+	2	580	c.216G>A	c.(214-216)GCG>GCA	p.A72A	ARHGAP25_uc010yqk.1_Silent_p.A46A|ARHGAP25_uc010fdg.2_Silent_p.A72A|ARHGAP25_uc010yql.1_Silent_p.A72A|ARHGAP25_uc002sev.2_Silent_p.A65A|ARHGAP25_uc002sew.2_Silent_p.A65A|ARHGAP25_uc002sex.2_Silent_p.A65A|ARHGAP25_uc010fdh.1_Intron	NM_001007231	NP_001007232	P42331	RHG25_HUMAN	Rho GTPase activating protein 25 isoform a	72	PH.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			ovary(2)|breast(2)	4						TGCTGAGGGCGCAGCAGCTCT	0.597			NA											3	78					0	0	0.009096	0	0
ARHGAP25	9938	broad.mit.edu	37	2	69015026	69015026	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr2:69015026C>A	uc002seu.2	+	4	768	c.404C>A	c.(403-405)TCT>TAT	p.S135Y	ARHGAP25_uc010yqk.1_Missense_Mutation_p.S109Y|ARHGAP25_uc010fdg.2_Missense_Mutation_p.S135Y|ARHGAP25_uc010yql.1_Intron|ARHGAP25_uc002sev.2_Missense_Mutation_p.S128Y|ARHGAP25_uc002sew.2_Missense_Mutation_p.S128Y|ARHGAP25_uc002sex.2_Missense_Mutation_p.S128Y|ARHGAP25_uc010fdh.1_RNA	NM_001007231	NP_001007232	P42331	RHG25_HUMAN	Rho GTPase activating protein 25 isoform a	135	PH.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			ovary(2)|breast(2)	4						ATGGCCAGCTCTCAGGCGGAG	0.542			NA											44	76					2.52991e-16	4.0192e-16	0.00361	1	0
ANTXR1	84168	broad.mit.edu	37	2	69302789	69302789	+	Missense_Mutation	SNP	A	A	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr2:69302789A>T	uc002sfg.2	+	7	916	c.560A>T	c.(559-561)CAG>CTG	p.Q187L	ANTXR1_uc002sfe.2_Missense_Mutation_p.Q187L|ANTXR1_uc002sff.2_Missense_Mutation_p.Q187L|ANTXR1_uc002sfd.2_Missense_Mutation_p.Q187L	NM_032208	NP_115584	Q9H6X2	ANTR1_HUMAN	anthrax toxin receptor 1 isoform 1 precursor	187	Extracellular (Potential).|VWFA.				actin cytoskeleton reorganization|substrate adhesion-dependent cell spreading	filopodium membrane|integral to membrane|lamellipodium membrane	actin filament binding|collagen binding|metal ion binding|protein binding|transmembrane receptor activity			ovary(2)|skin(2)	4						AATGAGACACAGGTATGGTAA	0.408			NA							Familial_Infantile_Hemangioma				52	110					0	0	0.00361	0	0
AAK1	22848	broad.mit.edu	37	2	69734643	69734643	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr2:69734643C>G	uc002sfp.2	-	15	2579	c.2074G>C	c.(2074-2076)GGG>CGG	p.G692R	AAK1_uc010fdk.2_Missense_Mutation_p.G692R|AAK1_uc010yqm.1_Missense_Mutation_p.G693R	NM_014911	NP_055726	Q2M2I8	AAK1_HUMAN	AP2 associated kinase 1	692						coated pit|mitochondrion|plasma membrane	ATP binding|protein serine/threonine kinase activity				0						CACGTAGACCCTTCTGAAGGA	0.478			NA											8	9					0	0	0.004482	0	0
DYSF	8291	broad.mit.edu	37	2	71741043	71741043	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr2:71741043G>T	uc002sie.2	+	6	1031	c.655G>T	c.(655-657)GAT>TAT	p.D219Y	DYSF_uc010feg.2_Missense_Mutation_p.D250Y|DYSF_uc010feh.2_Missense_Mutation_p.D219Y|DYSF_uc002sig.3_Missense_Mutation_p.D219Y|DYSF_uc010yqx.1_RNA|DYSF_uc010fee.2_Missense_Mutation_p.D219Y|DYSF_uc010fef.2_Missense_Mutation_p.D250Y|DYSF_uc010fei.2_Missense_Mutation_p.D250Y|DYSF_uc010fek.2_Missense_Mutation_p.D251Y|DYSF_uc010fej.2_Missense_Mutation_p.D220Y|DYSF_uc010fel.2_Missense_Mutation_p.D220Y|DYSF_uc010feo.2_Missense_Mutation_p.D251Y|DYSF_uc010fem.2_Missense_Mutation_p.D220Y|DYSF_uc010fen.2_Missense_Mutation_p.D251Y|DYSF_uc002sif.2_Missense_Mutation_p.D220Y	NM_003494	NP_003485	O75923	DYSF_HUMAN	dysferlin isoform 8	219	Cytoplasmic (Potential).|C2 2.					cytoplasmic vesicle membrane|integral to membrane|sarcolemma	calcium-dependent phospholipid binding			ovary(3)|breast(2)|pancreas(1)|skin(1)	7						CAAACCGCAGGATTTCCAGGT	0.572			NA											12	37					9.05144e-12	1.30675e-11	0.001855	1	0
DYSF	8291	broad.mit.edu	37	2	71883330	71883330	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr2:71883330G>T	uc002sie.2	+	42	4924	c.4548G>T	c.(4546-4548)GAG>GAT	p.E1516D	DYSF_uc010feg.2_Missense_Mutation_p.E1547D|DYSF_uc010feh.2_Missense_Mutation_p.E1523D|DYSF_uc002sig.3_Missense_Mutation_p.E1502D|DYSF_uc010yqx.1_RNA|DYSF_uc010fee.2_Missense_Mutation_p.E1537D|DYSF_uc010fef.2_Missense_Mutation_p.E1554D|DYSF_uc010fei.2_Missense_Mutation_p.E1533D|DYSF_uc010fek.2_Missense_Mutation_p.E1534D|DYSF_uc010fej.2_Missense_Mutation_p.E1524D|DYSF_uc010fel.2_Missense_Mutation_p.E1503D|DYSF_uc010feo.2_Missense_Mutation_p.E1548D|DYSF_uc010fem.2_Missense_Mutation_p.E1538D|DYSF_uc010fen.2_Missense_Mutation_p.E1555D|DYSF_uc002sif.2_Missense_Mutation_p.E1517D|DYSF_uc010yqy.1_Missense_Mutation_p.E397D|DYSF_uc010yqz.1_Missense_Mutation_p.E277D	NM_003494	NP_003485	O75923	DYSF_HUMAN	dysferlin isoform 8	1516	Cytoplasmic (Potential).					cytoplasmic vesicle membrane|integral to membrane|sarcolemma	calcium-dependent phospholipid binding			ovary(3)|breast(2)|pancreas(1)|skin(1)	7						AGGCCTTTGAGGGCCTGTCTG	0.388			NA											115	187					1.49341e-58	2.78982e-58	0.00361	1	0
TET3	200424	broad.mit.edu	37	2	74274555	74274555	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr2:74274555C>T	uc002skb.3	+	1	1106	c.1106C>T	c.(1105-1107)TCC>TTC	p.S369F	TET3_uc010fez.1_Missense_Mutation_p.S369F	NM_144993	NP_659430	O43151	TET3_HUMAN	tet oncogene family member 3	369							metal ion binding|methylcytosine dioxygenase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen				0						CCGGCCCCATCCCCTGTACTT	0.652			NA											8	11					0	0	0.00308	0	0
TACR1	6869	broad.mit.edu	37	2	75278480	75278480	+	Missense_Mutation	SNP	A	A	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr2:75278480A>T	uc002sng.2	-	4	1415	c.830T>A	c.(829-831)CTC>CAC	p.L277H	TACR1_uc002snh.2_Missense_Mutation_p.L277H	NM_001058	NP_001049	P25103	NK1R_HUMAN	tachykinin receptor 1 isoform long	277	Extracellular (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|detection of abiotic stimulus|mechanosensory behavior	integral to plasma membrane	protein binding			ovary(1)	1					Aprepitant(DB00673)|Ketamine(DB01221)|Vapreotide(DB04894)	CTTCAGGTAGAGATCTGGGTT	0.527	Pancreas(64;62 1268 3653 14826 43765)		NA											34	87					0	0	0.003271	0	0
IMMT	10989	broad.mit.edu	37	2	86371621	86371621	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr2:86371621C>G	uc002sqz.3	-	15	2435	c.2047G>C	c.(2047-2049)GAG>CAG	p.E683Q	IMMT_uc002sqy.3_Missense_Mutation_p.E424Q|IMMT_uc002srb.3_Missense_Mutation_p.E672Q|IMMT_uc002sra.3_Missense_Mutation_p.E682Q|IMMT_uc010ytd.1_Missense_Mutation_p.E671Q|IMMT_uc010yte.1_Missense_Mutation_p.E636Q	NM_006839	NP_006830	Q16891	IMMT_HUMAN	inner membrane protein, mitochondrial isoform 1	683	Mitochondrial intermembrane (Potential).					integral to mitochondrial inner membrane	protein binding			skin(1)	1						TTTATATCCTCAGGGCAGAGC	0.473			NA											9	23					0	0	0.004482	0	0
ASTL	431705	broad.mit.edu	37	2	96798449	96798449	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr2:96798449C>G	uc010yui.1	-	6	467	c.467G>C	c.(466-468)AGT>ACT	p.S156T		NM_001002036	NP_001002036	Q6HA08	ASTL_HUMAN	astacin-like metalloendopeptidase precursor	156					proteolysis		metalloendopeptidase activity|zinc ion binding				0						GCGCCCCACACTCGAGAAGCA	0.622			NA											10	52					0	0	0.006214	0	0
VWA3B	200403	broad.mit.edu	37	2	98872621	98872621	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr2:98872621C>A	uc002syo.2	+	21	3091	c.2827C>A	c.(2827-2829)CAA>AAA	p.Q943K	VWA3B_uc002sym.2_Missense_Mutation_p.Q943K|VWA3B_uc002syn.1_RNA|VWA3B_uc010yvi.1_Missense_Mutation_p.Q600K|VWA3B_uc002syp.1_Missense_Mutation_p.Q335K|VWA3B_uc002syq.1_Missense_Mutation_p.Q219K|VWA3B_uc002syr.1_Missense_Mutation_p.Q260K|VWA3B_uc002sys.2_RNA	NM_144992	NP_659429	Q502W6	VWA3B_HUMAN	von Willebrand factor A domain containing 3B	943										ovary(3)|large_intestine(2)|skin(1)	6						AGCATTATCTCAAGAGGAAAA	0.249			NA											6	51					0.00198382	0.00213454	0.001984	1	0
CNGA3	1261	broad.mit.edu	37	2	99012508	99012508	+	Missense_Mutation	SNP	A	A	C			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr2:99012508A>C	uc002syt.2	+	8	1292	c.875A>C	c.(874-876)GAG>GCG	p.E292A	CNGA3_uc002syu.2_Missense_Mutation_p.E274A|CNGA3_uc010fij.2_Missense_Mutation_p.E296A	NM_001298	NP_001289	Q16281	CNGA3_HUMAN	cyclic nucleotide gated channel alpha 3 isoform	292					signal transduction|visual perception	integral to membrane	cGMP binding			ovary(5)|upper_aerodigestive_tract(1)	6						GACCGCACAGAGACAAGGACC	0.473			NA											25	23					0	0	0.003954	0	0
IL18RAP	8807	broad.mit.edu	37	2	103053770	103053770	+	Silent	SNP	G	G	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr2:103053770G>A	uc002tbx.2	+	6	1162	c.678G>A	c.(676-678)TCG>TCA	p.S226S	IL18RAP_uc010fiz.2_Silent_p.S84S	NM_003853	NP_003844	O95256	I18RA_HUMAN	interleukin 18 receptor accessory protein	226	Ig-like C2-type 1.|Extracellular (Potential).				cell surface receptor linked signaling pathway|inflammatory response|innate immune response	integral to membrane	transmembrane receptor activity			skin(3)|ovary(2)	5						ACACTCAGTCGGATACTGTGA	0.413			NA											11	62					0	0	0.001368	0	0
ST6GAL2	84620	broad.mit.edu	37	2	107459530	107459530	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr2:107459530C>A	uc002tdq.2	-	2	1023	c.904G>T	c.(904-906)GCA>TCA	p.A302S	ST6GAL2_uc002tdr.2_Missense_Mutation_p.A302S|ST6GAL2_uc002tds.3_Missense_Mutation_p.A302S	NM_001142351	NP_001135823	Q96JF0	SIAT2_HUMAN	ST6 beta-galactosamide	302	Lumenal (Potential).				growth|multicellular organismal development|oligosaccharide metabolic process|protein glycosylation	Golgi cisterna membrane|integral to Golgi membrane	beta-galactoside alpha-2,6-sialyltransferase activity			pancreas(6)|ovary(4)|skin(1)	11						ATTGCGCCTGCAGACATGACG	0.697			NA											3	5					0.00024832	0.000277424	0.009096	1	0
ANAPC1	64682	broad.mit.edu	37	2	112615883	112615883	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr2:112615883C>A	uc002thi.2	-	11	1605	c.1358G>T	c.(1357-1359)CGC>CTC	p.R453L		NM_022662	NP_073153	Q9H1A4	APC1_HUMAN	anaphase promoting complex subunit 1	453					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination	anaphase-promoting complex|cytosol|nucleoplasm				skin(2)	2						ATACACCTACCGTAACTGGAG	0.308			NA											8	26					0.00448238	0.00476433	0.004482	1	0
CNTNAP5	129684	broad.mit.edu	37	2	125504840	125504840	+	Silent	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr2:125504840C>A	uc002tno.2	+	14	2473	c.2109C>A	c.(2107-2109)TCC>TCA	p.S703S	CNTNAP5_uc010flu.2_Silent_p.S704S	NM_130773	NP_570129	Q8WYK1	CNTP5_HUMAN	contactin associated protein-like 5 precursor	703	Extracellular (Potential).|Fibrinogen C-terminal.				cell adhesion|signal transduction	integral to membrane	receptor binding			ovary(10)	10				BRCA - Breast invasive adenocarcinoma(221;0.248)		TTGGGCGGTCCAATGAAAGGC	0.542			NA											19	23					3.99206e-14	6.05116e-14	0.007413	1	0
GPR17	2840	broad.mit.edu	37	2	128408738	128408738	+	Silent	SNP	C	C	G			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr2:128408738C>G	uc010yzn.1	+	4	1124	c.513C>G	c.(511-513)CGC>CGG	p.R171R	LIMS2_uc002tow.2_5'Flank|LIMS2_uc002tox.2_Intron|LIMS2_uc010fmb.2_Intron|LIMS2_uc002toy.2_Intron|LIMS2_uc010yzm.1_Intron|LIMS2_uc002tpa.2_Intron|LIMS2_uc002toz.2_Intron|LIMS2_uc002tpb.2_Intron|GPR17_uc002tpc.2_Silent_p.R171R|GPR17_uc010yzo.1_Silent_p.R143R|GPR17_uc002tpd.2_Silent_p.R143R	NM_001161415	NP_001154887	Q13304	GPR17_HUMAN	G protein-coupled receptor 17 isoform a	171	Cytoplasmic (Potential).					integral to plasma membrane	chemokine receptor activity|purinergic nucleotide receptor activity, G-protein coupled				0	Colorectal(110;0.1)	Ovarian(717;0.15)		BRCA - Breast invasive adenocarcinoma(221;0.0677)		TCAAGCTCCGCAGGCCCCTCT	0.627			NA											18	105					0	0	0.010504	0	0
TUBA3E	112714	broad.mit.edu	37	2	130949494	130949494	+	Silent	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr2:130949494G>T	uc002tqv.2	-	5	1364	c.1263C>A	c.(1261-1263)GCC>GCA	p.A421A		NM_207312	NP_997195	Q6PEY2	TBA3E_HUMAN	tubulin, alpha 3e	421					microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|structural molecule activity			skin(1)	1	Colorectal(110;0.1)					GGTCCTCGCGGGCCTCAGAGA	0.587			NA											35	212					9.62906e-15	1.47612e-14	0.00623	1	0
PTPN18	26469	broad.mit.edu	37	2	131126739	131126739	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr2:131126739G>C	uc002trc.2	+	6	549	c.448G>C	c.(448-450)GAG>CAG	p.E150Q	PTPN18_uc002trd.2_Missense_Mutation_p.E150Q|PTPN18_uc002trb.2_Missense_Mutation_p.E43Q|PTPN18_uc002tre.2_5'Flank	NM_014369	NP_055184	Q99952	PTN18_HUMAN	protein tyrosine phosphatase, non-receptor type	150	Tyrosine-protein phosphatase.					cytoplasm|nucleus	non-membrane spanning protein tyrosine phosphatase activity			ovary(3)|kidney(1)	4	Colorectal(110;0.1)					CCAGGAGCAGGAGCCACTGCA	0.537			NA											48	187					0	0	0.00361	0	0
POTEE	445582	broad.mit.edu	37	2	132021826	132021826	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr2:132021826G>T	uc002tsn.2	+	15	2850	c.2798G>T	c.(2797-2799)AGC>ATC	p.S933I	PLEKHB2_uc002tsh.2_Intron|POTEE_uc002tsk.2_Missense_Mutation_p.S533I|POTEE_uc002tsl.2_Missense_Mutation_p.S515I|POTEE_uc010fmy.1_Missense_Mutation_p.S397I	NM_001083538	NP_001077007	Q6S8J3	POTEE_HUMAN	protein expressed in prostate, ovary, testis,	933	Actin-like.						ATP binding				0						GCGGCCTCCAGCTCCTCCCTA	0.617			NA											56	195					1.53134e-21	2.57882e-21	0.00361	1	0
LOC401010	401010	broad.mit.edu	37	2	132201684	132201684	+	Missense_Mutation	SNP	T	T	C			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr2:132201684T>C	uc002tst.2	-	1	784	c.318A>G	c.(316-318)ATA>ATG	p.I106M		NR_002826				SubName: Full=cDNA FLJ12694 fis, clone NT2RP1000358, highly similar to Homo sapiens mRNA; cDNA DKFZp564C186 (from clone DKFZp564C186);												0						ACACTAGCTGTATGACCGAGC	0.622			NA											7	17					0	0	0.000978	0	0
R3HDM1	23518	broad.mit.edu	37	2	136437836	136437836	+	Missense_Mutation	SNP	A	A	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr2:136437836A>T	uc002tuo.2	+	20	2666	c.2296A>T	c.(2296-2298)ACA>TCA	p.T766S	R3HDM1_uc010fni.2_Missense_Mutation_p.T765S|R3HDM1_uc002tup.2_Missense_Mutation_p.T711S|R3HDM1_uc010zbh.1_Missense_Mutation_p.T514S	NM_015361	NP_056176	Q15032	R3HD1_HUMAN	R3H domain containing 1	766							nucleic acid binding			skin(1)	1				BRCA - Breast invasive adenocarcinoma(221;0.127)		ATCTATGCCCACAACAGGAAT	0.403			NA											48	57					0	0	0.00361	0	0
SPOPL	339745	broad.mit.edu	37	2	139322383	139322383	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr2:139322383G>A	uc002tvh.2	+	9	1343	c.943G>A	c.(943-945)GAA>AAA	p.E315K		NM_001001664	NP_001001664	Q6IQ16	SPOPL_HUMAN	speckle-type POZ protein-like	315						nucleus				skin(2)|breast(1)	3				BRCA - Breast invasive adenocarcinoma(221;0.0296)		GCACAGTGCAGAACAGTTGAA	0.403			NA											42	126					0	0	0.002852	0	0
LRP1B	53353	broad.mit.edu	37	2	141110584	141110584	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr2:141110584C>G	uc002tvj.1	-	76	12560	c.11588G>C	c.(11587-11589)GGA>GCA	p.G3863A		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	3863	Extracellular (Potential).|EGF-like 9.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		TTTATATGATCCTTCCACATT	0.338	Colon(99;50 2074 2507 20106)		NA								TSP Lung(27;0.18)			31	73					0	0	0.003271	0	0
LRP1B	53353	broad.mit.edu	37	2	141202233	141202233	+	Missense_Mutation	SNP	T	T	G			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr2:141202233T>G	uc002tvj.1	-	64	11045	c.10073A>C	c.(10072-10074)CAG>CCG	p.Q3358P		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	3358	Extracellular (Potential).|LDL-receptor class A 22.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		TCGGCCTGGCTGACATCTAAA	0.408	Colon(99;50 2074 2507 20106)		NA								TSP Lung(27;0.18)			12	69					0	0	0.00245	0	0
LRP1B	53353	broad.mit.edu	37	2	141260667	141260667	+	Silent	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr2:141260667G>T	uc002tvj.1	-	54	9499	c.8527C>A	c.(8527-8529)CGA>AGA	p.R2843R		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	2843	Extracellular (Potential).				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		CCACACTGTCGATATCCTAGA	0.398	Colon(99;50 2074 2507 20106)		NA								TSP Lung(27;0.18)			4	49					0.00116845	0.00126823	0.001168	1	0
LRP1B	53353	broad.mit.edu	37	2	141680656	141680656	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr2:141680656C>A	uc002tvj.1	-	21	4169	c.3197G>T	c.(3196-3198)TGC>TTC	p.C1066F	LRP1B_uc010fnl.1_Missense_Mutation_p.C248F	NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	1066	Extracellular (Potential).|LDL-receptor class A 8.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		ATCAGGAACGCAATTACCATC	0.438	Colon(99;50 2074 2507 20106)		NA								TSP Lung(27;0.18)			10	58					3.86212e-05	4.42789e-05	0.008291	1	0
ZEB2	9839	broad.mit.edu	37	2	145161502	145161502	+	Missense_Mutation	SNP	T	T	C			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr2:145161502T>C	uc002tvu.2	-	6	1268	c.788A>G	c.(787-789)CAC>CGC	p.H263R	ZEB2_uc002tvv.2_Missense_Mutation_p.H257R|ZEB2_uc010zbm.1_Missense_Mutation_p.H234R|ZEB2_uc010fnp.2_Missense_Mutation_p.H171R|ZEB2_uc010fnq.1_Missense_Mutation_p.H292R	NM_014795	NP_055610	O60315	ZEB2_HUMAN	zinc finger homeobox 1b	263	C2H2-type 2.					cytoplasm|nucleolus	phosphatase regulator activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|SMAD binding|zinc ion binding			ovary(5)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)	9				BRCA - Breast invasive adenocarcinoma(221;0.112)		CCCTGGCTTGTGTGTCACCAT	0.403	Melanoma(33;1235 1264 5755 16332)		NA											102	93					0	0	0.00361	0	0
TNFAIP6	7130	broad.mit.edu	37	2	152220529	152220529	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr2:152220529C>A	uc002txk.2	+	2	243	c.167C>A	c.(166-168)GCG>GAG	p.A56E		NM_007115	NP_009046	P98066	TSG6_HUMAN	tumor necrosis factor, alpha-induced protein 6	56	Link.				cell adhesion|cell-cell signaling|inflammatory response|signal transduction		hyaluronic acid binding				0				BRCA - Breast invasive adenocarcinoma(221;0.131)		GAAGCTAAGGCGGTGTGTGAA	0.448			NA											7	64					2.0095e-06	2.44928e-06	0.001984	1	0
NEB	4703	broad.mit.edu	37	2	152420221	152420221	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr2:152420221C>G	uc010fnx.2	-	91	13680	c.13489G>C	c.(13489-13491)GAG>CAG	p.E4497Q	NEB_uc002txr.2_Missense_Mutation_p.E920Q	NM_004543	NP_004534	P20929	NEBU_HUMAN	nebulin isoform 3	4497	Nebulin 123.				muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			ovary(8)|large_intestine(5)|breast(3)|central_nervous_system(2)|skin(1)|pancreas(1)	20				BRCA - Breast invasive adenocarcinoma(221;0.219)		TCATATGTCTCTTTGTATTTA	0.448			NA											65	155					0	0	0.00361	0	0
NEB	4703	broad.mit.edu	37	2	152500419	152500419	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr2:152500419G>T	uc010fnx.2	-	57	8060	c.7869C>A	c.(7867-7869)GAC>GAA	p.D2623E		NM_004543	NP_004534	P20929	NEBU_HUMAN	nebulin isoform 3	2623	Nebulin 70.				muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			ovary(8)|large_intestine(5)|breast(3)|central_nervous_system(2)|skin(1)|pancreas(1)	20				BRCA - Breast invasive adenocarcinoma(221;0.219)		AGTTCTTGTAGTCCACGTCGC	0.552			NA											62	224					1.33661e-31	2.386e-31	0.00361	1	0
STAM2	10254	broad.mit.edu	37	2	152989690	152989690	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr2:152989690C>T	uc002tyc.3	-	10	1317	c.967G>A	c.(967-969)GAA>AAA	p.E323K	STAM2_uc010foa.1_Missense_Mutation_p.E323K|STAM2_uc002tyd.2_Missense_Mutation_p.E323K	NM_005843	NP_005834	O75886	STAM2_HUMAN	signal transducing adaptor molecule 2	323					cellular membrane organization|endosome transport|epidermal growth factor receptor signaling pathway|intracellular protein transport|negative regulation of epidermal growth factor receptor signaling pathway	cytosol|early endosome membrane	protein binding			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(221;0.22)		TAAGTACCTTCTAAATCCAAA	0.333			NA											9	61					0	0	0.008291	0	0
GALNT13	114805	broad.mit.edu	37	2	155295238	155295238	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr2:155295238G>T	uc002tyr.3	+	12	2097	c.1530G>T	c.(1528-1530)GAG>GAT	p.E510D	GALNT13_uc002tyt.3_Missense_Mutation_p.E510D|GALNT13_uc010fod.2_3'UTR|uc002tyu.1_Intron	NM_052917	NP_443149	Q8IUC8	GLT13_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide	510	Ricin B-type lectin.|Lumenal (Potential).					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			ovary(2)|pancreas(2)|central_nervous_system(1)|skin(1)	6						ATGATGCTGAGGTATAGTATT	0.318			NA											8	64					6.40141e-05	7.28859e-05	0.000978	1	0
PKP4	8502	broad.mit.edu	37	2	159477908	159477908	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr2:159477908G>C	uc002tzv.2	+	6	838	c.578G>C	c.(577-579)AGA>ACA	p.R193T	PKP4_uc002tzt.1_Missense_Mutation_p.R45T|PKP4_uc002tzu.2_Missense_Mutation_p.R193T|PKP4_uc002tzw.2_Missense_Mutation_p.R193T|PKP4_uc002tzx.2_5'UTR|PKP4_uc002tzy.1_5'UTR|PKP4_uc002tzz.1_Missense_Mutation_p.R191T|PKP4_uc002uaa.2_Missense_Mutation_p.R45T	NM_003628	NP_003619	Q99569	PKP4_HUMAN	plakophilin 4 isoform a	193					cell adhesion	desmosome	protein binding			ovary(5)|skin(2)	7						AGGAATTCAAGAGCTGAAGGA	0.388			NA								HNSCC(62;0.18)			14	22					0	0	0.004007	0	0
TANC1	85461	broad.mit.edu	37	2	160035567	160035567	+	Silent	SNP	C	C	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr2:160035567C>T	uc002uag.2	+	14	2677	c.2403C>T	c.(2401-2403)TTC>TTT	p.F801F	TANC1_uc010fol.1_Silent_p.F695F|TANC1_uc010zcm.1_Silent_p.F793F|TANC1_uc010fom.1_Silent_p.F607F|TANC1_uc002uai.1_RNA	NM_033394	NP_203752	Q9C0D5	TANC1_HUMAN	tetratricopeptide repeat, ankyrin repeat and	801						cell junction|postsynaptic density|postsynaptic membrane	binding			ovary(2)|central_nervous_system(1)	3						TCTCCTGCTTCCTCATTAAGA	0.557			NA											33	92					0	0	0.002836	0	0
TBR1	10716	broad.mit.edu	37	2	162279953	162279953	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr2:162279953G>T	uc002ubw.1	+	6	1566	c.1264G>T	c.(1264-1266)GGG>TGG	p.G422W	TBR1_uc010foy.2_Missense_Mutation_p.G135W	NM_006593	NP_006584	Q16650	TBR1_HUMAN	T-box, brain, 1	422						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|central_nervous_system(1)	2						GATCGTGCCCGGGGCCCGCTA	0.577			NA											40	23					4.14194e-30	7.34971e-30	0.002852	1	0
COBLL1	22837	broad.mit.edu	37	2	165559624	165559624	+	Silent	SNP	T	T	C			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr2:165559624T>C	uc010zcw.1	-	12	1654	c.1530A>G	c.(1528-1530)ACA>ACG	p.T510T	COBLL1_uc002ucp.2_Silent_p.T444T|COBLL1_uc002ucq.2_Intron|COBLL1_uc010zcx.1_Intron|COBLL1_uc002ucs.1_RNA|COBLL1_uc002uco.2_Intron	NM_014900	NP_055715	Q53SF7	COBL1_HUMAN	COBL-like 1	482										ovary(2)|pancreas(1)	3						ATGTCAATGATGTTATGGCTG	0.502			NA											131	144					0	0	0.00361	0	0
TTC21B	79809	broad.mit.edu	37	2	166747379	166747379	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr2:166747379C>T	uc002udk.2	-	23	3203	c.3070G>A	c.(3070-3072)GGA>AGA	p.G1024R	TTC21B_uc002udj.1_RNA	NM_024753	NP_079029	Q7Z4L5	TT21B_HUMAN	tetratricopeptide repeat domain 21B	1024	TPR 16.					cilium axoneme|cytoplasm|cytoskeleton	binding			ovary(2)|pancreas(2)|breast(1)	5						TACTGAAATCCTGGTTCCAAT	0.333			NA											6	41					0	0	0.001168	0	0
XIRP2	129446	broad.mit.edu	37	2	167992470	167992470	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr2:167992470G>T	uc002udx.2	+	2	478	c.460G>T	c.(460-462)GGG>TGG	p.G154W	XIRP2_uc010fpn.2_Missense_Mutation_p.G154W|XIRP2_uc010fpo.2_Missense_Mutation_p.G154W|XIRP2_uc010fpp.2_Missense_Mutation_p.G154W|XIRP2_uc002udy.2_5'UTR	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	Error:Variant_position_missing_in_A4UGR9_after_alignment					actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14						GAGTCACCCTGGGAGCCAGCT	0.433			NA											22	61					7.88262e-20	1.30529e-19	0.00333	1	0
XIRP2	129446	broad.mit.edu	37	2	168101740	168101740	+	Nonsense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr2:168101740G>T	uc002udx.2	+	8	3856	c.3838G>T	c.(3838-3840)GAG>TAG	p.E1280*	XIRP2_uc010fpn.2_Intron|XIRP2_uc010fpo.2_Intron|XIRP2_uc010fpp.2_Intron|XIRP2_uc002udy.2_Nonsense_Mutation_p.E1105*|XIRP2_uc010fpq.2_Nonsense_Mutation_p.E1058*|XIRP2_uc010fpr.2_Intron|XIRP2_uc010fps.1_5'Flank	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	1105	Xin 21.				actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14						CTTTATTTTTGAGACTTTTTC	0.353			NA											4	93					1.23904e-05	1.44506e-05	0.000602	1	0
LASS6	253782	broad.mit.edu	37	2	169571583	169571583	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr2:169571583G>A	uc002ueb.1	+	7	806	c.682G>A	c.(682-684)GCC>ACC	p.A228T	LASS6_uc002uec.1_Missense_Mutation_p.A228T	NM_203463	NP_982288	Q6ZMG9	CERS6_HUMAN	longevity assurance homolog 6	228	Cytoplasmic (Potential).|TLC.					endoplasmic reticulum membrane|integral to membrane|nuclear membrane	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|sphingosine N-acyltransferase activity			skin(1)	1						CAACAATATGGCCCGAGTAGG	0.363			NA											42	46					0	0	0.00361	0	0
DCAF17	80067	broad.mit.edu	37	2	172309638	172309638	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr2:172309638G>C	uc002ugx.2	+	6	771	c.542G>C	c.(541-543)GGC>GCC	p.G181A	DCAF17_uc010zdq.1_RNA|DCAF17_uc010fqf.1_Missense_Mutation_p.G181A|DCAF17_uc010zdr.1_RNA|DCAF17_uc010fqg.2_5'UTR	NM_025000	NP_079276	Q5H9S7	DCA17_HUMAN	DDB1 and CUL4 associated factor 17 isoform 1	181						CUL4 RING ubiquitin ligase complex|integral to membrane|nucleolus					0						TTCTAGGCAGGCATTCAACAA	0.378			NA											4	63					0	0	0.001168	0	0
RAPGEF4	11069	broad.mit.edu	37	2	173855632	173855632	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr2:173855632G>C	uc002uhv.3	+	15	1656	c.1469G>C	c.(1468-1470)GGA>GCA	p.G490A	RAPGEF4_uc002uhw.3_Missense_Mutation_p.G346A|RAPGEF4_uc010zec.1_Missense_Mutation_p.G337A|RAPGEF4_uc010zed.1_Missense_Mutation_p.G319A|RAPGEF4_uc010zee.1_Missense_Mutation_p.G337A|RAPGEF4_uc010fqo.2_Missense_Mutation_p.G319A|RAPGEF4_uc010zef.1_Missense_Mutation_p.G270A|RAPGEF4_uc010zeg.1_Missense_Mutation_p.G317A|RAPGEF4_uc010zeh.1_Missense_Mutation_p.G270A	NM_007023	NP_008954	Q8WZA2	RPGF4_HUMAN	Rap guanine nucleotide exchange factor (GEF) 4	490					blood coagulation|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|regulation of insulin secretion|regulation of protein phosphorylation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cAMP-dependent protein kinase complex|membrane fraction|plasma membrane	cAMP binding|cAMP-dependent protein kinase regulator activity|Ras GTPase binding|Ras guanyl-nucleotide exchange factor activity			large_intestine(2)|skin(2)|kidney(1)|central_nervous_system(1)	6			OV - Ovarian serous cystadenocarcinoma(117;0.194)			TCTAATCAAGGAAACTCACAG	0.433			NA											14	31					0	0	0.00499	0	0
TTC30A	92104	broad.mit.edu	37	2	178483321	178483321	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr2:178483321C>G	uc002ulo.2	-	1	374	c.109G>C	c.(109-111)GAA>CAA	p.E37Q		NM_152275	NP_689488	Q86WT1	TT30A_HUMAN	tetratricopeptide repeat domain 30A	37	TPR 1.				cell projection organization	cilium	binding				0			OV - Ovarian serous cystadenocarcinoma(117;0.000423)|Epithelial(96;0.00373)|all cancers(119;0.0169)			CGCTGCAGTTCTCGGCCCAGC	0.687			NA											4	7					0	0	0.009096	0	0
TTN	7273	broad.mit.edu	37	2	179428686	179428686	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr2:179428686C>G	uc010zfg.1	-	275	74693	c.74469G>C	c.(74467-74469)TGG>TGC	p.W24823C	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.W18518C|TTN_uc010zfi.1_Missense_Mutation_p.W18451C|TTN_uc010zfj.1_Missense_Mutation_p.W18326C	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	25750							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AAGGTGGGTTCCATGCCAGGT	0.473			NA											9	55					0	0	0.006214	0	0
TTN	7273	broad.mit.edu	37	2	179430746	179430746	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr2:179430746C>G	uc010zfg.1	-	275	72633	c.72409G>C	c.(72409-72411)GAG>CAG	p.E24137Q	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.E17832Q|TTN_uc010zfi.1_Missense_Mutation_p.E17765Q|TTN_uc010zfj.1_Missense_Mutation_p.E17640Q	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	25064							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ATGGGTGGCTCCCATACCAGG	0.438			NA											23	95					0	0	0.003954	0	0
TTN	7273	broad.mit.edu	37	2	179432829	179432829	+	Silent	SNP	C	C	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr2:179432829C>T	uc010zfg.1	-	275	70550	c.70326G>A	c.(70324-70326)CAG>CAA	p.Q23442Q	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Silent_p.Q17137Q|TTN_uc010zfi.1_Silent_p.Q17070Q|TTN_uc010zfj.1_Silent_p.Q16945Q	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	24369							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GTTCATGCCACTGTATGACCA	0.448			NA											7	46					0	0	0.004482	0	0
TTN	7273	broad.mit.edu	37	2	179436812	179436812	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr2:179436812C>T	uc010zfg.1	-	275	66567	c.66343G>A	c.(66343-66345)GAA>AAA	p.E22115K	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.E15810K|TTN_uc010zfi.1_Missense_Mutation_p.E15743K|TTN_uc010zfj.1_Missense_Mutation_p.E15618K	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	23042							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GAGTATTCTTCACCCTGAATT	0.478			NA											8	27					0	0	0.008291	0	0
TTN	7273	broad.mit.edu	37	2	179436945	179436945	+	Silent	SNP	C	C	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr2:179436945C>T	uc010zfg.1	-	275	66434	c.66210G>A	c.(66208-66210)GAG>GAA	p.E22070E	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Silent_p.E15765E|TTN_uc010zfi.1_Silent_p.E15698E|TTN_uc010zfj.1_Silent_p.E15573E	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	22997							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GCTCTGGTTTCTCCCAAGAGA	0.478			NA											11	29					0	0	0.000978	0	0
TTN	7273	broad.mit.edu	37	2	179465646	179465646	+	Missense_Mutation	SNP	A	A	C			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr2:179465646A>C	uc010zfg.1	-	237	48505	c.48281T>G	c.(48280-48282)GTC>GGC	p.V16094G	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.V9789G|TTN_uc010zfi.1_Missense_Mutation_p.V9722G|TTN_uc010zfj.1_Missense_Mutation_p.V9597G	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	17021							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TGCAGCATTGACAGCTTTGAC	0.478			NA											28	134					0	0	0.003271	0	0
TTN	7273	broad.mit.edu	37	2	179480037	179480037	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr2:179480037G>T	uc010zfg.1	-	208	41155	c.40931C>A	c.(40930-40932)ACA>AAA	p.T13644K	uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.T7339K|TTN_uc010zfi.1_Missense_Mutation_p.T7272K|TTN_uc010zfj.1_Missense_Mutation_p.T7147K	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	14571							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AACCTACTTTGTTTCTGCAAC	0.373			NA											5	45					5.9392e-07	7.35353e-07	0.001168	1	0
TTN	7273	broad.mit.edu	37	2	179588354	179588354	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr2:179588354C>A	uc010zfg.1	-	71	17965	c.17741G>T	c.(17740-17742)AGC>ATC	p.S5914I	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.S2575I	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	6841							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCTAATAACGCTTGTGAAGGT	0.418			NA											6	19					0.00116845	0.00126823	0.001168	1	0
TTN	7273	broad.mit.edu	37	2	179615829	179615829	+	Silent	SNP	A	A	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr2:179615829A>T	uc002unb.2	-	46	11522	c.11298T>A	c.(11296-11298)GCT>GCA	p.A3766A	TTN_uc010zfg.1_Intron|TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Intron	NM_133379	NP_596870	Q8WZ42	TITIN_HUMAN	titin isoform novex-3	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CAATACTCTCAGCTGAATGAT	0.358			NA											40	50					0	0	0.00623	0	0
TTN	7273	broad.mit.edu	37	2	179638602	179638602	+	Silent	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr2:179638602G>T	uc010zfg.1	-	31	7517	c.7293C>A	c.(7291-7293)GCC>GCA	p.A2431A	TTN_uc010zfh.1_Silent_p.A2385A|TTN_uc010zfi.1_Silent_p.A2385A|TTN_uc010zfj.1_Silent_p.A2385A|TTN_uc002unb.2_Silent_p.A2431A	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	2431							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AGAGGCCAAGGGCTGGAATGG	0.403			NA											13	102					6.31663e-08	8.15349e-08	0.003163	1	0
TTN	7273	broad.mit.edu	37	2	179645895	179645895	+	Missense_Mutation	SNP	C	C	A	rs149883066		TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr2:179645895C>A	uc010zfg.1	-	21	3700	c.3476G>T	c.(3475-3477)CGC>CTC	p.R1159L	TTN_uc010zfh.1_Missense_Mutation_p.R1113L|TTN_uc010zfi.1_Missense_Mutation_p.R1113L|TTN_uc010zfj.1_Missense_Mutation_p.R1113L|TTN_uc002unb.2_Missense_Mutation_p.R1159L	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	1159							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ATGCTTATTGCGAACAACAAT	0.388			NA											27	23					1.16021e-09	1.58715e-09	0.007291	1	0
CERKL	375298	broad.mit.edu	37	2	182413481	182413481	+	Silent	SNP	C	C	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr2:182413481C>T	uc002unx.2	-	8	1178	c.1077G>A	c.(1075-1077)CTG>CTA	p.L359L	CERKL_uc002uny.2_Silent_p.L333L|CERKL_uc010zfm.1_Silent_p.L315L|CERKL_uc002unz.2_Silent_p.L81L|CERKL_uc002uoa.2_Silent_p.L264L|CERKL_uc002uob.2_Silent_p.L81L|CERKL_uc002uoc.2_Silent_p.L220L|CERKL_uc010frk.2_RNA|CERKL_uc002uod.1_Silent_p.L128L|CERKL_uc002uoe.2_Silent_p.L333L|CERKL_uc002unw.2_5'Flank	NM_001030311	NP_001025482	Q49MI3	CERKL_HUMAN	ceramide kinase-like isoform b	359					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|anti-apoptosis	endoplasmic reticulum|endoplasmic reticulum|Golgi apparatus|Golgi apparatus|nucleolus|nucleolus	diacylglycerol kinase activity			ovary(2)|kidney(1)|skin(1)	4			OV - Ovarian serous cystadenocarcinoma(117;0.088)			ATTTTTCTGCCAGAGCCAAAG	0.453			NA											8	50					0	0	0.00308	0	0
SSFA2	6744	broad.mit.edu	37	2	182783599	182783599	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr2:182783599G>A	uc002uoi.2	+	13	3305	c.2983G>A	c.(2983-2985)GAG>AAG	p.E995K	SSFA2_uc002uoh.2_Missense_Mutation_p.E995K|SSFA2_uc002uoj.2_Missense_Mutation_p.E995K|SSFA2_uc002uok.2_RNA|SSFA2_uc010zfo.1_Missense_Mutation_p.E842K|SSFA2_uc002uol.2_Missense_Mutation_p.E842K|SSFA2_uc002uom.2_Missense_Mutation_p.E463K	NM_001130445	NP_001123917	P28290	SSFA2_HUMAN	sperm specific antigen 2 isoform 1	995	Potential.					cytoplasm|plasma membrane	actin binding			breast(1)|central_nervous_system(1)	2			OV - Ovarian serous cystadenocarcinoma(117;0.0856)			TCATATGACTGAGGAGGAGAG	0.358			NA											17	44					0	0	0.010504	0	0
COL3A1	1281	broad.mit.edu	37	2	189857656	189857656	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr2:189857656C>A	uc002uqj.1	+	15	1157	c.1040C>A	c.(1039-1041)CCT>CAT	p.P347H	COL3A1_uc010frw.1_RNA	NM_000090	NP_000081	P02461	CO3A1_HUMAN	collagen type III alpha 1 preproprotein	347	Triple-helical region.				axon guidance|cell-matrix adhesion|collagen biosynthetic process|collagen fibril organization|fibril organization|heart development|integrin-mediated signaling pathway|negative regulation of immune response|peptide cross-linking|platelet activation|response to cytokine stimulus|response to radiation|skin development|transforming growth factor beta receptor signaling pathway	collagen type III|extracellular space	extracellular matrix structural constituent|integrin binding|platelet-derived growth factor binding			central_nervous_system(7)|ovary(4)|large_intestine(2)	13			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.141)		Collagenase(DB00048)|Palifermin(DB00039)	CCTGGATCCCCTGGTGCTAAG	0.388			NA											5	65					5.9392e-07	7.35353e-07	0.001168	1	0
OBFC2A	64859	broad.mit.edu	37	2	192543851	192543851	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr2:192543851G>A	uc002usx.2	+	2	707	c.227G>A	c.(226-228)AGA>AAA	p.R76K	OBFC2A_uc002usw.2_5'UTR|OBFC2A_uc002usy.2_RNA|OBFC2A_uc002usz.2_RNA|OBFC2A_uc002uta.2_5'UTR	NM_001031716	NP_001026886	Q96AH0	SOSB2_HUMAN	oligonucleotide/oligosaccharide-binding fold	76	OB.				double-strand break repair via homologous recombination|G2/M transition checkpoint|response to ionizing radiation	SOSS complex	single-stranded DNA binding				0			OV - Ovarian serous cystadenocarcinoma(117;0.061)|Epithelial(96;0.244)			CGGTTGACCAGAGGGTAGGTG	0.527			NA											16	67					0	0	0.008871	0	0
SGOL2	151246	broad.mit.edu	37	2	201438346	201438346	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr2:201438346C>G	uc002uvw.2	+	7	3390	c.3277C>G	c.(3277-3279)CAT>GAT	p.H1093D	SGOL2_uc010zhd.1_Missense_Mutation_p.H1093D|SGOL2_uc010zhe.1_Missense_Mutation_p.H1093D	NM_152524	NP_689737	Q562F6	SGOL2_HUMAN	shugoshin-like 2 isoform 1	1093					cell division|mitotic prometaphase	condensed chromosome kinetochore|cytosol|mitotic cohesin complex	protein binding			ovary(2)|skin(2)	4						TCCAGAGAGCCATGAAGTAAT	0.368			NA											13	66					0	0	0.00245	0	0
ALS2	57679	broad.mit.edu	37	2	202603421	202603421	+	Nonsense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr2:202603421C>A	uc002uyo.2	-	12	2745	c.2389G>T	c.(2389-2391)GGA>TGA	p.G797*	ALS2_uc002uyp.3_Nonsense_Mutation_p.G797*|ALS2_uc010ftl.2_RNA	NM_020919	NP_065970	Q96Q42	ALS2_HUMAN	alsin isoform 1	797	DH.				cell death|endosome organization|positive regulation of Rac GTPase activity|regulation of endosome size	centrosome|cytosol|early endosome|growth cone|lamellipodium|protein complex|ruffle	protein homodimerization activity|protein serine/threonine kinase activator activity|Rab GTPase binding|Rab guanyl-nucleotide exchange factor activity|Rac guanyl-nucleotide exchange factor activity|Ran guanyl-nucleotide exchange factor activity			skin(5)|lung(1)|breast(1)	7						AGCTGGAATCCTCCCATAACC	0.383			NA											9	44					1.08611e-07	1.38156e-07	0.000978	1	0
FZD7	8324	broad.mit.edu	37	2	202901057	202901057	+	Nonsense_Mutation	SNP	A	A	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr2:202901057A>T	uc002uyw.1	+	1	1748	c.1687A>T	c.(1687-1689)AGA>TGA	p.R563*		NM_003507	NP_003498	O75084	FZD7_HUMAN	frizzled 7 precursor	563	Cytoplasmic (Potential).				axonogenesis|brain development|canonical Wnt receptor signaling pathway|cellular response to retinoic acid|G-protein signaling, coupled to cGMP nucleotide second messenger|gonad development|mesenchymal to epithelial transition|negative regulation of cell-substrate adhesion|negative regulation of ectodermal cell fate specification|positive regulation of epithelial cell proliferation involved in wound healing|positive regulation of phosphorylation|positive regulation of transcription, DNA-dependent|regulation of catenin import into nucleus|vasculature development|Wnt receptor signaling pathway, calcium modulating pathway	apical part of cell|cytoplasm|integral to membrane|neuron projection membrane	G-protein coupled receptor activity|PDZ domain binding|Wnt receptor activity|Wnt-protein binding			skin(2)|ovary(1)|breast(1)	4						CTTCTACCACAGACTTAGCCA	0.612			NA											33	37					0	0	0.004289	0	0
MAP2	4133	broad.mit.edu	37	2	210574909	210574909	+	Silent	SNP	A	A	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr2:210574909A>T	uc002vde.1	+	12	5252	c.5004A>T	c.(5002-5004)CCA>CCT	p.P1668P	MAP2_uc002vdd.1_Silent_p.P369P|MAP2_uc002vdf.1_Silent_p.P312P|MAP2_uc002vdg.1_Silent_p.P312P|MAP2_uc002vdh.1_Silent_p.P369P|MAP2_uc002vdi.1_Silent_p.P1664P	NM_002374	NP_002365	P11137	MAP2_HUMAN	microtubule-associated protein 2 isoform 1	1668	Tau/MAP 1.				central nervous system neuron development|dendrite morphogenesis|negative regulation of microtubule depolymerization	cytoplasm|microtubule|microtubule associated complex	beta-dystroglycan binding|calmodulin binding|structural molecule activity			ovary(9)|upper_aerodigestive_tract(2)|large_intestine(2)|pancreas(2)|central_nervous_system(1)|skin(1)	17		Hepatocellular(293;0.137)|Lung NSC(271;0.163)|Renal(323;0.202)		UCEC - Uterine corpus endometrioid carcinoma (47;6.64e-05)|Epithelial(149;3.12e-100)|all cancers(144;6.88e-91)|Lung(261;0.0624)|LUSC - Lung squamous cell carcinoma(261;0.0662)|STAD - Stomach adenocarcinoma(1183;0.18)	Estramustine(DB01196)	AACCACTGCCAGACCTGAAGA	0.478	Pancreas(27;423 979 28787 29963)		NA											5	5					0	0	0.000602	0	0
UNC80	285175	broad.mit.edu	37	2	210642116	210642116	+	Missense_Mutation	SNP	A	A	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr2:210642116A>T	uc010zjc.1	+	4	513	c.433A>T	c.(433-435)AGC>TGC	p.S145C	UNC80_uc002vdj.1_Missense_Mutation_p.S145C	NM_032504	NP_115893	Q8N2C7	UNC80_HUMAN	chromosome 2 open reading frame 21 isoform 1	145						integral to membrane					0						GGGTGGAAGCAGCAGTGCTTT	0.547			NA											7	37					0	0	0.00308	0	0
CPS1	1373	broad.mit.edu	37	2	211527880	211527880	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr2:211527880G>T	uc002vee.3	+	33	4093	c.3961G>T	c.(3961-3963)GCT>TCT	p.A1321S	CPS1_uc010fur.2_Missense_Mutation_p.A1327S|CPS1_uc010fus.2_Missense_Mutation_p.A870S	NM_001875	NP_001866	P31327	CPSM_HUMAN	carbamoyl-phosphate synthetase 1 isoform b	1321					carbamoyl phosphate biosynthetic process|citrulline biosynthetic process|glutamine metabolic process|glycogen catabolic process|nitric oxide metabolic process|positive regulation of vasodilation|response to lipopolysaccharide|triglyceride catabolic process|urea cycle	mitochondrial nucleoid	ATP binding|carbamoyl-phosphate synthase (ammonia) activity			ovary(8)|central_nervous_system(3)|breast(1)|skin(1)	13				Epithelial(149;0.00697)|Lung(261;0.0521)|LUSC - Lung squamous cell carcinoma(261;0.0544)|all cancers(144;0.0843)		GTTGAGGGATGCTGACCCCAT	0.398			NA											12	82					2.32078e-09	3.14299e-09	0.003163	1	0
ERBB4	2066	broad.mit.edu	37	2	212426702	212426702	+	Missense_Mutation	SNP	A	A	C			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr2:212426702A>C	uc002veg.1	-	20	2511	c.2413T>G	c.(2413-2415)TTG>GTG	p.L805V	ERBB4_uc002veh.1_Missense_Mutation_p.L805V|ERBB4_uc010zji.1_Missense_Mutation_p.L795V|ERBB4_uc010zjj.1_Missense_Mutation_p.L795V|ERBB4_uc010fut.1_Missense_Mutation_p.L805V	NM_005235	NP_005226	Q15303	ERBB4_HUMAN	v-erb-a erythroblastic leukemia viral oncogene	805	Protein kinase.|Cytoplasmic (Potential).				cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent|transmembrane receptor protein tyrosine kinase signaling pathway	basolateral plasma membrane|cytoplasm|integral to membrane|nucleus	ATP binding|protein binding|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			lung(21)|skin(5)|stomach(2)|breast(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	33		Renal(323;0.06)|Lung NSC(271;0.197)		UCEC - Uterine corpus endometrioid carcinoma (47;0.214)|Epithelial(149;5.86e-06)|all cancers(144;2.95e-05)|Lung(261;0.00244)|LUSC - Lung squamous cell carcinoma(224;0.00266)		ACATACTCCAACAGGCAGCCA	0.493			NA								TSP Lung(8;0.080)			18	156					0	0	0.007413	0	0
IKZF2	22807	broad.mit.edu	37	2	213921620	213921620	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr2:213921620C>T	uc002vem.2	-	4	512	c.343G>A	c.(343-345)GAC>AAC	p.D115N	IKZF2_uc010fuu.2_Intron|IKZF2_uc002vej.2_Missense_Mutation_p.D62N|IKZF2_uc002vek.2_RNA|IKZF2_uc010fuv.2_Intron|IKZF2_uc002vel.2_Intron|IKZF2_uc010fuw.2_5'UTR|IKZF2_uc010fux.2_Intron|IKZF2_uc010fuy.2_Intron|IKZF2_uc002ven.2_Intron	NM_016260	NP_057344	Q9UKS7	IKZF2_HUMAN	helios isoform 1	115	C2H2-type 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Esophageal squamous(248;0.0559)|Renal(323;0.218)		UCEC - Uterine corpus endometrioid carcinoma (47;0.214)|Epithelial(149;2.97e-07)|all cancers(144;1.53e-05)|LUSC - Lung squamous cell carcinoma(224;0.00599)|Lung(261;0.00792)		CCACAGACGTCACATTTCAGT	0.498			NA											20	58					0	0	0.001882	0	0
ZNF142	7701	broad.mit.edu	37	2	219509212	219509212	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr2:219509212C>A	uc002vin.2	-	8	2463	c.2027G>T	c.(2026-2028)GGG>GTG	p.G676V	ZNF142_uc002vil.2_Missense_Mutation_p.G637V|ZNF142_uc010fvt.2_Missense_Mutation_p.G513V|ZNF142_uc002vim.2_Missense_Mutation_p.G513V	NM_001105537	NP_001099007	P52746	ZN142_HUMAN	zinc finger protein 142	676					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|ovary(1)|skin(1)	4		Renal(207;0.0474)		Epithelial(149;5.21e-07)|all cancers(144;0.000106)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)		CAGGTCACCCCCATGGGGAGC	0.632	Colon(170;867 1942 8995 15834 18053)		NA											23	32					6.32553e-13	9.41548e-13	0.004656	1	0
CCDC108	255101	broad.mit.edu	37	2	219888887	219888887	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr2:219888887C>G	uc002vjl.1	-	15	2529	c.2445G>C	c.(2443-2445)CAG>CAC	p.Q815H		NM_194302	NP_919278	Q6ZU64	CC108_HUMAN	coiled-coil domain containing 108 isoform 1	815						integral to membrane	structural molecule activity			ovary(2)|upper_aerodigestive_tract(1)|pancreas(1)	4		Renal(207;0.0915)		Epithelial(149;1.12e-06)|all cancers(144;0.000196)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		CTGAGCCTCTCTGGGGGGCCA	0.632			NA											9	51					0	0	0.004482	0	0
IHH	3549	broad.mit.edu	37	2	219920417	219920417	+	Nonsense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr2:219920417C>A	uc002vjo.1	-	3	748	c.748G>T	c.(748-750)GAG>TAG	p.E250*		NM_002181	NP_002172	Q14623	IHH_HUMAN	Indian hedgehog homolog precursor	250					cell-cell signaling|intein-mediated protein splicing|proteolysis	extracellular space|plasma membrane	cholesterol binding|patched binding|peptidase activity			breast(1)	1		Renal(207;0.0915)		Epithelial(149;1.13e-06)|all cancers(144;0.000188)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		CTGTGAGGCTCGCGGTCCAGG	0.642			NA											26	13					2.85442e-18	4.65408e-18	0.002096	1	0
TUBA4B	80086	broad.mit.edu	37	2	220136173	220136173	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr2:220136173C>A	uc002vkv.1	+	4	643	c.478C>A	c.(478-480)CGC>AGC	p.R160S	TUBA4B_uc002vku.2_Intron	NR_003063				RecName: Full=Putative tubulin-like protein alpha-4B; AltName: Full=Alpha-tubulin 4B;												0						AGACATCGAGCGCCCAACCTA	0.532			NA											16	63					3.51602e-12	5.14092e-12	0.008871	1	0
SPEG	10290	broad.mit.edu	37	2	220329177	220329177	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr2:220329177C>A	uc010fwg.2	+	9	2728	c.2728C>A	c.(2728-2730)CGC>AGC	p.R910S	SPEG_uc002vlm.2_RNA|SPEG_uc010fwh.1_Missense_Mutation_p.R118S|SPEG_uc002vln.1_Missense_Mutation_p.R118S|SPEG_uc002vlp.1_Missense_Mutation_p.R118S|SPEG_uc002vlq.2_Missense_Mutation_p.R61S	NM_005876	NP_005867	Q15772	SPEG_HUMAN	SPEG complex locus	910	Ig-like 3.				muscle organ development|negative regulation of cell proliferation	nucleus	ATP binding|protein serine/threonine kinase activity			stomach(9)|ovary(4)|central_nervous_system(1)	14		Renal(207;0.0183)		Epithelial(149;4.5e-10)|all cancers(144;7.93e-08)|Lung(261;0.00639)|LUSC - Lung squamous cell carcinoma(224;0.00829)|READ - Rectum adenocarcinoma(5;0.163)		CCAGCCCGTGCGCCCAGACCA	0.657			NA											19	55					3.08376e-08	4.02595e-08	0.00333	1	0
MRPL44	65080	broad.mit.edu	37	2	224822340	224822340	+	Silent	SNP	C	C	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr2:224822340C>T	uc002vnr.3	+	1	220	c.151C>T	c.(151-153)CTG>TTG	p.L51L		NM_022915	NP_075066	Q9H9J2	RM44_HUMAN	mitochondrial ribosomal protein L44 precursor	51					RNA processing	mitochondrion|ribosome	double-stranded RNA binding|protein binding|ribonuclease III activity			central_nervous_system(1)	1		all_lung(227;0.00679)|Lung NSC(271;0.00855)|Renal(207;0.0112)|all_hematologic(139;0.189)		Epithelial(121;2.51e-10)|all cancers(144;7.89e-08)|Lung(261;0.00705)|LUSC - Lung squamous cell carcinoma(224;0.008)		GCAGCGCCTTCTGCGGTGCCC	0.697			NA											4	12					0	0	0.009096	0	0
SERPINE2	5270	broad.mit.edu	37	2	224862913	224862913	+	Missense_Mutation	SNP	A	A	G	rs11548971		TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr2:224862913A>G	uc002vnu.2	-	3	649	c.406T>C	c.(406-408)TGT>CGT	p.C136R	SERPINE2_uc002vnt.2_Missense_Mutation_p.C136R|SERPINE2_uc010zlr.1_Missense_Mutation_p.C148R|SERPINE2_uc002vnv.2_Missense_Mutation_p.C136R	NM_006216	NP_006207	P07093	GDN_HUMAN	plasminogen activator inhibitor type 1, member 2	136					negative regulation of blood coagulation|negative regulation of plasminogen activation|negative regulation of platelet aggregation|positive regulation of astrocyte differentiation|regulation of cell migration	cytosol|extracellular matrix|extracellular space|extrinsic to external side of plasma membrane|neuromuscular junction|platelet alpha granule	heparin binding|receptor binding|serine-type endopeptidase inhibitor activity			breast(2)|ovary(1)|central_nervous_system(1)	4		Renal(207;0.025)|all_lung(227;0.0586)|Lung NSC(271;0.0682)|all_hematologic(139;0.0797)		Epithelial(121;5.68e-10)|all cancers(144;1.9e-07)|Lung(261;0.0088)|LUSC - Lung squamous cell carcinoma(224;0.00902)		CGGACCTCACACTGGAACACA	0.448			NA											9	32					0	0	0.008291	0	0
COL4A4	1286	broad.mit.edu	37	2	227886843	227886843	+	Silent	SNP	T	T	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr2:227886843T>A	uc010zlt.1	-	43	4791	c.4137A>T	c.(4135-4137)CCA>CCT	p.P1379P		NM_000092	NP_000083	P53420	CO4A4_HUMAN	alpha 4 type IV collagen precursor	1379	Triple-helical region.				axon guidance|glomerular basement membrane development	basal lamina|collagen type IV	extracellular matrix structural constituent|protein binding			ovary(5)|central_nervous_system(3)|pancreas(1)|breast(1)|skin(1)	11		Renal(207;0.00844)|all_lung(227;0.0187)|Lung NSC(271;0.0879)|all_hematologic(139;0.21)|Esophageal squamous(248;0.242)		Epithelial(121;6.7e-11)|all cancers(144;5.39e-08)|Lung(261;0.0132)|LUSC - Lung squamous cell carcinoma(224;0.0181)		CAGGAAGGCCTGGGATTCGGG	0.582			NA											43	160					0	0	0.00361	0	0
DNER	92737	broad.mit.edu	37	2	230456418	230456418	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr2:230456418G>T	uc002vpv.2	-	2	610	c.463C>A	c.(463-465)CCT>ACT	p.P155T		NM_139072	NP_620711	Q8NFT8	DNER_HUMAN	delta-notch-like EGF repeat-containing	155	Extracellular (Potential).				central nervous system development|endocytosis|neuron migration|Notch signaling pathway|synapse assembly	dendrite|early endosome|integral to membrane|plasma membrane	calcium ion binding|clathrin binding|transmembrane receptor activity			lung(5)|ovary(2)|skin(1)	8		all_lung(227;0.00413)|Renal(207;0.0113)|Lung NSC(271;0.0211)|all_hematologic(139;0.105)|Acute lymphoblastic leukemia(138;0.175)		Epithelial(121;1.4e-11)|all cancers(144;7.7e-09)|LUSC - Lung squamous cell carcinoma(224;0.034)|Lung(119;0.0375)		GCAGGAACAGGCTGAAGCTGT	0.557			NA											8	51					2.17888e-05	2.52532e-05	0.006214	1	0
ARMC9	80210	broad.mit.edu	37	2	232156095	232156095	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr2:232156095C>G	uc002vrq.3	+	18	1768	c.1656C>G	c.(1654-1656)ATC>ATG	p.I552M	ARMC9_uc002vrp.3_Missense_Mutation_p.I552M|ARMC9_uc002vrr.1_RNA	NM_025139	NP_079415	Q7Z3E5	ARMC9_HUMAN	armadillo repeat containing 9	552							binding			ovary(1)	1		Renal(207;0.0112)|all_lung(227;0.0744)|all_hematologic(139;0.0749)|Acute lymphoblastic leukemia(138;0.167)|Medulloblastoma(418;0.184)|Lung NSC(271;0.205)		Epithelial(121;1.43e-10)|LUSC - Lung squamous cell carcinoma(224;0.017)|Lung(119;0.0189)		GCTGCTTCATCAAAGAAGGCA	0.388			NA											24	153					0	0	0.002836	0	0
ALPI	248	broad.mit.edu	37	2	233321707	233321707	+	Silent	SNP	A	A	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr2:233321707A>T	uc002vst.3	+	4	476	c.399A>T	c.(397-399)GCA>GCT	p.A133A	ALPI_uc002vsu.3_Silent_p.A44A	NM_001631	NP_001622	P09923	PPBI_HUMAN	intestinal alkaline phosphatase precursor	133					phosphorylation	anchored to membrane|integral to membrane|plasma membrane	alkaline phosphatase activity|metal ion binding|protein binding			central_nervous_system(1)	1		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;1.64e-16)|Kidney(3;9.71e-08)|KIRC - Kidney renal clear cell carcinoma(3;2.74e-06)|BRCA - Breast invasive adenocarcinoma(100;0.000763)|Lung(119;0.00564)|LUSC - Lung squamous cell carcinoma(224;0.00746)		GCTTGAGTGCAGCCGCCCGCT	0.617			NA											6	47					0	0	0.001984	0	0
CHRND	1144	broad.mit.edu	37	2	233393274	233393274	+	Silent	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr2:233393274G>T	uc002vsw.2	+	5	421	c.417G>T	c.(415-417)GTG>GTT	p.V139V	CHRND_uc010zmg.1_Silent_p.V124V|CHRND_uc010fyc.2_Missense_Mutation_p.C49F|CHRND_uc010zmh.1_Missense_Mutation_p.C49F	NM_000751	NP_000742	Q07001	ACHD_HUMAN	nicotinic acetylcholine receptor delta	139	Extracellular (Potential).				muscle contraction|musculoskeletal movement|neuromuscular process|skeletal muscle tissue growth|synaptic transmission	cell junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	nicotinic acetylcholine-activated cation-selective channel activity|receptor activity			ovary(1)|breast(1)|skin(1)	3		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;1.89e-16)|BRCA - Breast invasive adenocarcinoma(100;0.00078)|Lung(119;0.00579)|LUSC - Lung squamous cell carcinoma(224;0.00754)		ACGGCTTCGTGTACTGGCTGC	0.577			NA											95	102					8.26238e-36	1.50197e-35	0.00361	1	0
CHRND	1144	broad.mit.edu	37	2	233393335	233393335	+	Missense_Mutation	SNP	T	T	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr2:233393335T>A	uc002vsw.2	+	5	482	c.478T>A	c.(478-480)TTC>ATC	p.F160I	CHRND_uc010zmg.1_Missense_Mutation_p.F145I|CHRND_uc010fyc.2_Silent_p.P69P|CHRND_uc010zmh.1_Silent_p.P69P	NM_000751	NP_000742	Q07001	ACHD_HUMAN	nicotinic acetylcholine receptor delta	160	Extracellular (Potential).				muscle contraction|musculoskeletal movement|neuromuscular process|skeletal muscle tissue growth|synaptic transmission	cell junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	nicotinic acetylcholine-activated cation-selective channel activity|receptor activity			ovary(1)|breast(1)|skin(1)	3		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;1.89e-16)|BRCA - Breast invasive adenocarcinoma(100;0.00078)|Lung(119;0.00579)|LUSC - Lung squamous cell carcinoma(224;0.00754)		CTATTTCCCCTTCGACTGGCA	0.577			NA											17	103					0	0	0.00278	0	0
NGEF	25791	broad.mit.edu	37	2	233791856	233791857	+	Nonsense_Mutation	DNP	CC	CC	AA			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr2:233791856_233791857CC>AA	uc002vts.2	-	4	671_672	c.423_424GG>TT	c.(421-426)GAGGAG>GATTAG	p.141_142EE>D*	NGEF_uc010fyg.1_Nonsense_Mutation_p.49_50EE>D*|NGEF_uc002vtt.2_Nonsense_Mutation_p.49_50EE>D*	NM_019850	NP_062824	Q8N5V2	NGEF_HUMAN	neuronal guanine nucleotide exchange factor	141_142	Regulatory region; modulates activity toward RHOA, RAC1 and CDC42 (By similarity).				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|growth cone|plasma membrane	Rho guanyl-nucleotide exchange factor activity			ovary(3)|central_nervous_system(3)|skin(1)	7		Breast(86;0.00279)|Renal(207;0.00339)|all_hematologic(139;0.00793)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0271)|Lung NSC(271;0.0839)		Epithelial(121;8.65e-17)|BRCA - Breast invasive adenocarcinoma(100;0.00037)|LUSC - Lung squamous cell carcinoma(224;0.00813)|Lung(119;0.00984)|GBM - Glioblastoma multiforme(43;0.0604)		GCCGGCCACTCCTCGGGCGTGG	0.629			NA											10	48					0	0	0.004672	0	0
NGEF	25791	broad.mit.edu	37	2	233839474	233839474	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr2:233839474G>C	uc002vts.2	-	2	375	c.127C>G	c.(127-129)CAA>GAA	p.Q43E		NM_019850	NP_062824	Q8N5V2	NGEF_HUMAN	neuronal guanine nucleotide exchange factor	43	Regulatory region; modulates activity toward RHOA, RAC1 and CDC42 (By similarity).				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|growth cone|plasma membrane	Rho guanyl-nucleotide exchange factor activity			ovary(3)|central_nervous_system(3)|skin(1)	7		Breast(86;0.00279)|Renal(207;0.00339)|all_hematologic(139;0.00793)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0271)|Lung NSC(271;0.0839)		Epithelial(121;8.65e-17)|BRCA - Breast invasive adenocarcinoma(100;0.00037)|LUSC - Lung squamous cell carcinoma(224;0.00813)|Lung(119;0.00984)|GBM - Glioblastoma multiforme(43;0.0604)		TGGTCAGCTTGAGAAGTCTCC	0.443			NA											21	80					0	0	0.001882	0	0
ATG16L1	55054	broad.mit.edu	37	2	234191392	234191392	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr2:234191392G>C	uc002vty.2	+	12	1453	c.1196G>C	c.(1195-1197)CGA>CCA	p.R399P	ATG16L1_uc002vtx.1_Missense_Mutation_p.R236P|ATG16L1_uc002vua.2_Missense_Mutation_p.R380P|ATG16L1_uc002vub.2_Missense_Mutation_p.R257P|ATG16L1_uc002vtz.2_Missense_Mutation_p.R220P|ATG16L1_uc002vud.3_Missense_Mutation_p.R315P	NM_030803	NP_110430	Q676U5	A16L1_HUMAN	APG16 autophagy 16-like isoform 1	399	WD 2.				autophagic vacuole assembly|protein homooligomerization|protein transport	autophagic vacuole|pre-autophagosomal structure membrane	protein binding				0		Breast(86;0.0013)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0179)|Acute lymphoblastic leukemia(138;0.0327)|Lung NSC(271;0.0539)		Epithelial(121;1.53e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000379)|LUSC - Lung squamous cell carcinoma(224;0.00619)|Lung(119;0.00732)|GBM - Glioblastoma multiforme(43;0.11)		GATGATTATCGATTACGGGTA	0.413			NA											39	30					0	0	0.002852	0	0
UGT1A8	54576	broad.mit.edu	37	2	234526798	234526799	+	Missense_Mutation	DNP	CC	CC	AA			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr2:234526798_234526799CC>AA	uc002vup.2	+	1	508_509	c.445_446CC>AA	c.(445-447)CCT>AAT	p.P149N	UGT1A8_uc010zmv.1_Missense_Mutation_p.P149N	NM_019076	NP_061949	Q9HAW9	UD18_HUMAN	UDP glycosyltransferase 1 family, polypeptide A8	149					drug metabolic process|fatty acid metabolic process|flavone metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	enzyme inhibitor activity|fatty acid binding|glucuronosyltransferase activity|protein heterodimerization activity|protein homodimerization activity|steroid binding			ovary(2)	2		Breast(86;0.000766)|all_lung(227;0.00271)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0334)|Lung NSC(271;0.0461)|Lung SC(224;0.128)		Epithelial(121;2.56e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000482)|Lung(119;0.00404)|LUSC - Lung squamous cell carcinoma(224;0.008)		GTTTCTTGATCCTTTTGATGCC	0.396			NA											21	102					0	0	0.004672	0	0
TRPM8	79054	broad.mit.edu	37	2	234878934	234878934	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr2:234878934G>T	uc002vvh.2	+	17	2259	c.2219G>T	c.(2218-2220)TGG>TTG	p.W740L	TRPM8_uc010fyj.2_Intron	NM_024080	NP_076985	Q7Z2W7	TRPM8_HUMAN	transient receptor potential cation channel,	740	Helical; Name=2; (Potential).					integral to membrane				skin(4)	4		Breast(86;0.00205)|Renal(207;0.00694)|all_lung(227;0.0129)|Lung NSC(271;0.0408)|all_hematologic(139;0.0753)|Acute lymphoblastic leukemia(138;0.224)		Epithelial(121;1.19e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000139)|Lung(119;0.00758)|LUSC - Lung squamous cell carcinoma(224;0.0108)	Menthol(DB00825)	GTCTTCTCCTGGAATGTGGTC	0.552			NA											142	150					3.38734e-80	6.35982e-80	0.00361	1	0
ASB18	401036	broad.mit.edu	37	2	237172851	237172851	+	Silent	SNP	C	C	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr2:237172851C>T	uc010znh.1	-	1	138	c.138G>A	c.(136-138)GTG>GTA	p.V46V		NM_212556	NP_997721	Q6ZVZ8	ASB18_HUMAN	ankyrin repeat and SOCS box-containing 18	46					intracellular signal transduction					ovary(1)	1		all_hematologic(139;0.00615)|Renal(207;0.00963)|Breast(86;0.0126)|Acute lymphoblastic leukemia(138;0.0815)		Epithelial(121;2.04e-26)|OV - Ovarian serous cystadenocarcinoma(60;1.47e-11)|BRCA - Breast invasive adenocarcinoma(100;2.88e-05)|Lung(119;0.000383)|LUSC - Lung squamous cell carcinoma(224;0.00644)|GBM - Glioblastoma multiforme(43;0.244)		CCAGTTCTATCACAGCGTCCA	0.512			NA											8	35					0	0	0.00308	0	0
COL6A3	1293	broad.mit.edu	37	2	238244935	238244935	+	Silent	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr2:238244935C>A	uc002vwl.2	-	40	9093	c.8808G>T	c.(8806-8808)GTG>GTT	p.V2936V	COL6A3_uc002vwo.2_Silent_p.V2730V|COL6A3_uc010znj.1_Silent_p.V2329V|COL6A3_uc002vwj.2_Silent_p.V317V	NM_004369	NP_004360	P12111	CO6A3_HUMAN	alpha 3 type VI collagen isoform 1 precursor	2936	Nonhelical region.|Ala-rich.				axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			ovary(8)|central_nervous_system(6)|skin(2)|upper_aerodigestive_tract(1)|pancreas(1)	18		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		TTGCTGGCTTCACCGCCACTG	0.627			NA											35	41					1.60099e-16	2.55436e-16	0.004878	1	0
KIF1A	547	broad.mit.edu	37	2	241715308	241715308	+	Silent	SNP	G	G	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr2:241715308G>A	uc002vzy.2	-	11	1064	c.918C>T	c.(916-918)TAC>TAT	p.Y306Y	KIF1A_uc010fzk.2_Silent_p.Y306Y|KIF1A_uc002vzz.1_Silent_p.Y306Y	NM_004321	NP_004312	Q12756	KIF1A_HUMAN	axonal transport of synaptic vesicles	306	Kinesin-motor.				anterograde axon cargo transport	cytoplasm|microtubule|nucleus	ATP binding|microtubule motor activity			lung(1)	1		all_epithelial(40;1.35e-15)|Breast(86;2.14e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0295)|all_neural(83;0.0459)|Lung NSC(271;0.0942)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;6.12e-30)|all cancers(36;3.46e-27)|OV - Ovarian serous cystadenocarcinoma(60;1.38e-14)|Kidney(56;5e-09)|KIRC - Kidney renal clear cell carcinoma(57;5e-08)|BRCA - Breast invasive adenocarcinoma(100;5.87e-06)|Lung(119;0.00209)|LUSC - Lung squamous cell carcinoma(224;0.00902)|Colorectal(34;0.0282)|COAD - Colon adenocarcinoma(134;0.176)		CGGAATCTCGGTACGGAATGA	0.567			NA											3	48					0	0	0.009096	0	0
PASK	23178	broad.mit.edu	37	2	242066662	242066662	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr2:242066662C>G	uc002wao.1	-	10	1760	c.1668G>C	c.(1666-1668)GAG>GAC	p.E556D	PASK_uc010zol.1_Missense_Mutation_p.E370D|PASK_uc010zom.1_Missense_Mutation_p.E521D|PASK_uc010fzl.1_Missense_Mutation_p.E556D|PASK_uc010zon.1_Missense_Mutation_p.E337D|PASK_uc002wap.2_Missense_Mutation_p.E99D|PASK_uc002waq.2_Missense_Mutation_p.E556D	NM_015148	NP_055963	Q96RG2	PASK_HUMAN	PAS domain containing serine/threonine kinase	556					regulation of transcription, DNA-dependent	Golgi apparatus	ATP binding|identical protein binding|protein serine/threonine kinase activity|signal transducer activity			ovary(4)|lung(1)|skin(1)	6		all_cancers(19;4.46e-39)|all_epithelial(40;1.34e-17)|Breast(86;1.53e-05)|Renal(207;0.00179)|all_lung(227;0.00481)|Lung NSC(271;0.017)|Ovarian(221;0.0228)|Esophageal squamous(248;0.129)|all_hematologic(139;0.158)|Melanoma(123;0.16)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;1.34e-31)|all cancers(36;1e-28)|OV - Ovarian serous cystadenocarcinoma(60;3.53e-14)|Kidney(56;4.31e-09)|KIRC - Kidney renal clear cell carcinoma(57;4.35e-08)|BRCA - Breast invasive adenocarcinoma(100;5.64e-06)|Lung(119;0.000596)|LUSC - Lung squamous cell carcinoma(224;0.00481)|Colorectal(34;0.014)|COAD - Colon adenocarcinoma(134;0.0968)		TGCCCCCATCCTCAGCTGGGA	0.587			NA											23	172					0	0	0.003954	0	0
ANO7	50636	broad.mit.edu	37	2	242155594	242155594	+	Nonsense_Mutation	SNP	G	G	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr2:242155594G>A	uc002wax.2	+	19	2178	c.2075G>A	c.(2074-2076)TGG>TAG	p.W692*		NM_001001891	NP_001001891	Q6IWH7	ANO7_HUMAN	transmembrane protein 16G isoform NGEP long	692	Extracellular (Potential).					cell junction|chloride channel complex|cytosol	chloride channel activity			pancreas(2)|central_nervous_system(1)	3						CAGGGGCCCTGGGAGGACGAC	0.617			NA											3	15					0	0	0.004672	0	0
THAP4	51078	broad.mit.edu	37	2	242573057	242573058	+	Missense_Mutation	DNP	TC	TC	AA			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	TC	TC	-	-	TC	TC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr2:242573057_242573058TC>AA	uc002wbt.2	-	2	737_738	c.514_515GA>TT	c.(514-516)GAA>TTA	p.E172L		NM_015963	NP_057047	Q8WY91	THAP4_HUMAN	THAP domain containing 4 isoform 1	172							DNA binding|metal ion binding				0		all_cancers(19;2.09e-34)|all_epithelial(40;2.09e-14)|Breast(86;0.000141)|Renal(207;0.0143)|all_lung(227;0.0344)|Ovarian(221;0.069)|Lung NSC(271;0.0886)|Esophageal squamous(248;0.131)|all_hematologic(139;0.182)|Melanoma(123;0.2)		Epithelial(32;2.3e-33)|all cancers(36;8.99e-31)|OV - Ovarian serous cystadenocarcinoma(60;3.68e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;1.65e-06)|Lung(119;0.000152)|LUSC - Lung squamous cell carcinoma(224;0.00154)|Colorectal(34;0.0129)|COAD - Colon adenocarcinoma(134;0.0844)		TGGAGTCCGTTCCAGAGCTTGC	0.644			NA											8	27					0	0	0.004672	0	0
SIRPB2	284759	broad.mit.edu	37	20	1457984	1457984	+	Silent	SNP	T	T	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr20:1457984T>A	uc002wfg.2	-	4	1086	c.858A>T	c.(856-858)ACA>ACT	p.T286T	SIRPB2_uc002wfh.3_Silent_p.T188T|SIRPB2_uc010zpr.1_Silent_p.T148T	NM_001122962	NP_001116434	Q5JXA9	SIRB2_HUMAN	signal-regulatory protein beta 2 isoform 1	286	Extracellular (Potential).					integral to membrane					0						TACGCTCACCTGTTGGAGACA	0.537			NA											45	59					0	0	0.00361	0	0
OXT	5020	broad.mit.edu	37	20	3052344	3052344	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr20:3052344G>A	uc002wht.1	+	1	79	c.43G>A	c.(43-45)GCG>ACG	p.A15T		NM_000915	NP_000906	P01178	NEU1_HUMAN	oxytocin-neurophysin I preproprotein	15					signal transduction		neurohypophyseal hormone activity				0					Oxytocin(DB00107)	CGGCCTCCTGGCGCTGACCTC	0.721			NA											5	3					0	0	0.000602	0	0
PLCB1	23236	broad.mit.edu	37	20	8637874	8637874	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr20:8637874G>T	uc002wnb.2	+	8	641	c.638G>T	c.(637-639)AGA>ATA	p.R213I	PLCB1_uc010zrb.1_Missense_Mutation_p.R112I|PLCB1_uc002wna.2_Missense_Mutation_p.R213I|PLCB1_uc002wnc.1_Missense_Mutation_p.R112I	NM_015192	NP_056007	Q9NQ66	PLCB1_HUMAN	phosphoinositide-specific phospholipase C beta 1	213					activation of meiosis involved in egg activation|CD24 biosynthetic process|cerebral cortex development|G1 phase|G2/M transition of mitotic cell cycle|glutamate signaling pathway|insulin-like growth factor receptor signaling pathway|interleukin-1-mediated signaling pathway|interleukin-12-mediated signaling pathway|interleukin-15-mediated signaling pathway|intracellular signal transduction|lipid catabolic process|memory|muscarinic acetylcholine receptor signaling pathway|negative regulation of monocyte extravasation|negative regulation of transcription, DNA-dependent|phosphatidylinositol metabolic process|positive regulation of acrosome reaction|positive regulation of developmental growth|positive regulation of embryonic development|positive regulation of interleukin-12 production|positive regulation of JNK cascade|positive regulation of myoblast differentiation|positive regulation of transcription, DNA-dependent|regulation of fertilization|regulation of G-protein coupled receptor protein signaling pathway|synaptic transmission	cytosol|nuclear chromatin|nuclear speck	calcium ion binding|calmodulin binding|enzyme binding|GTPase activator activity|phosphatidylinositol phospholipase C activity|phosphatidylinositol-4,5-bisphosphate binding|protein homodimerization activity|signal transducer activity			ovary(4)|breast(3)|upper_aerodigestive_tract(2)|skin(2)|lung(1)	12						GAAGTGTACAGAGTTTTCCTC	0.323			NA											22	39					7.76418e-22	1.31646e-21	0.005443	1	0
PAK7	57144	broad.mit.edu	37	20	9560828	9560828	+	Nonsense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr20:9560828G>T	uc002wnl.2	-	5	1499	c.954C>A	c.(952-954)TAC>TAA	p.Y318*	PAK7_uc002wnk.2_Nonsense_Mutation_p.Y318*|PAK7_uc002wnj.2_Nonsense_Mutation_p.Y318*|PAK7_uc010gby.1_Nonsense_Mutation_p.Y318*	NM_020341	NP_065074	Q9P286	PAK7_HUMAN	p21-activated kinase 7	318	Linker.						ATP binding|protein binding|protein serine/threonine kinase activity			lung(11)|skin(5)|central_nervous_system(3)|ovary(2)|large_intestine(1)|stomach(1)	23			COAD - Colon adenocarcinoma(9;0.194)			ACAAGCGAGGGTAGGTGTAGG	0.547			NA											60	76					1.64915e-30	2.92986e-30	0.00361	1	0
SEL1L2	80343	broad.mit.edu	37	20	13894500	13894500	+	Silent	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr20:13894500G>T	uc010gcf.2	-	5	559	c.477C>A	c.(475-477)GGC>GGA	p.G159G	SEL1L2_uc002woq.3_Silent_p.G20G|SEL1L2_uc010zrl.1_Silent_p.G159G|SEL1L2_uc002wor.2_RNA	NM_025229	NP_079505	Q5TEA6	SE1L2_HUMAN	sel-1 suppressor of lin-12-like 2 precursor	159	Extracellular (Potential).|Sel1-like 2.					integral to membrane	binding			ovary(2)	2						TATTTTGCACGCCAAAATTTC	0.393			NA											19	16					2.94398e-08	3.84684e-08	0.007413	1	0
INSM1	3642	broad.mit.edu	37	20	20349229	20349229	+	Silent	SNP	G	G	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr20:20349229G>A	uc002wrx.2	+	1	465	c.318G>A	c.(316-318)GTG>GTA	p.V106V		NM_002196	NP_002187	Q01101	INSM1_HUMAN	insulinoma-associated 1	106	Ala/Gly/Pro-rich.				endocrine pancreas development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1				READ - Rectum adenocarcinoma(2;0.0649)		CGCGGCCCGTGAGCCGCGAGC	0.726			NA											6	3					0	0	0.001984	0	0
REM1	28954	broad.mit.edu	37	20	30064329	30064329	+	Silent	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr20:30064329C>A	uc002wwa.2	+	2	365	c.81C>A	c.(79-81)GGC>GGA	p.G27G		NM_014012	NP_054731	O75628	REM1_HUMAN	RAS-like GTP-binding protein REM	27					small GTPase mediated signal transduction	membrane	calmodulin binding|GTP binding|GTPase activity			lung(2)|pancreas(2)	4	all_cancers(5;0.000119)|Lung NSC(7;1.32e-05)|all_lung(7;2.14e-05)|all_hematologic(12;0.158)|Ovarian(7;0.198)		Colorectal(19;0.00254)|COAD - Colon adenocarcinoma(19;0.0347)			CCCCACGGGGCCACCAGCCTG	0.647			NA											18	51					4.96729e-08	6.42292e-08	0.008871	1	0
DNMT3B	1789	broad.mit.edu	37	20	31390254	31390254	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr20:31390254G>T	uc002wyc.2	+	20	2530	c.2209G>T	c.(2209-2211)GGC>TGC	p.G737C	DNMT3B_uc002wyd.2_Missense_Mutation_p.G717C|DNMT3B_uc002wye.2_Missense_Mutation_p.G717C|DNMT3B_uc010gee.2_RNA|DNMT3B_uc010gef.2_RNA|DNMT3B_uc010ztz.1_Missense_Mutation_p.G675C|DNMT3B_uc010zua.1_Missense_Mutation_p.G641C|DNMT3B_uc002wyf.2_Missense_Mutation_p.G729C|DNMT3B_uc002wyg.2_Missense_Mutation_p.G436C|DNMT3B_uc010geg.2_Missense_Mutation_p.G36C|DNMT3B_uc010geh.2_RNA	NM_006892	NP_008823	Q9UBC3	DNM3B_HUMAN	DNA cytosine-5 methyltransferase 3 beta isoform	737					negative regulation of histone H3-K9 methylation|positive regulation of gene expression|positive regulation of histone H3-K4 methylation		metal ion binding|protein binding|transcription corepressor activity			lung(3)|ovary(2)	5						ATACTTCTGGGGCAACCTACC	0.468			NA											40	79					1.00776e-21	1.70288e-21	0.00361	1	0
C20orf186	149954	broad.mit.edu	37	20	31685484	31685484	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr20:31685484C>A	uc010zue.1	+	11	1475	c.1460C>A	c.(1459-1461)CCA>CAA	p.P487Q		NM_182519	NP_872325	P59827	LPLC4_HUMAN	antimicrobial peptide RY2G5 precursor	487						cytoplasm|extracellular region	lipid binding				0						CTGAACCCACCATCTGTGATG	0.592			NA											37	92					1.66425e-11	2.38414e-11	0.004878	1	0
PLUNC	51297	broad.mit.edu	37	20	31825642	31825642	+	Nonsense_Mutation	SNP	T	T	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr20:31825642T>A	uc002wyv.2	+	2	195	c.125T>A	c.(124-126)TTG>TAG	p.L42*	PLUNC_uc002wyt.3_Nonsense_Mutation_p.L42*|PLUNC_uc002wyu.3_Nonsense_Mutation_p.L42*	NM_130852	NP_570913	Q9NP55	PLUNC_HUMAN	palate, lung and nasal epithelium associated	42					innate immune response	extracellular region	lipid binding				0						GCCCTGCCCTTGAGTCCCACA	0.438			NA											26	79					0	0	0.002096	0	0
C20orf114	92747	broad.mit.edu	37	20	31887734	31887734	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr20:31887734G>A	uc002wyw.1	+	8	852	c.691G>A	c.(691-693)GAG>AAG	p.E231K	C20orf114_uc002wyx.1_5'Flank	NM_033197	NP_149974	Q8TDL5	LPLC1_HUMAN	LPLUNC1 protein precursor	231						extracellular space	lipid binding			central_nervous_system(2)|skin(2)	4						TGACCGTCTGGAGTTTGACCT	0.557			NA									OREG0025869	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	25	72					0	0	0.002836	0	0
PHF20	51230	broad.mit.edu	37	20	34519296	34519296	+	Nonsense_Mutation	SNP	C	C	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr20:34519296C>T	uc002xek.1	+	15	2341	c.2230C>T	c.(2230-2232)CAG>TAG	p.Q744*		NM_016436	NP_057520	Q9BVI0	PHF20_HUMAN	PHD finger protein 20	744					regulation of transcription, DNA-dependent|transcription, DNA-dependent	MLL1 complex	DNA binding|zinc ion binding			ovary(1)	1	Breast(12;0.00631)|all_lung(11;0.0145)					GGCCACCCACCAGCTTCTTGG	0.527			NA											14	52					0	0	0.00499	0	0
C20orf117	140710	broad.mit.edu	37	20	35434280	35434280	+	Silent	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr20:35434280C>A	uc002xgd.1	-	9	2508	c.2181G>T	c.(2179-2181)ACG>ACT	p.T727T	C20orf117_uc002xge.1_RNA	NM_199181	NP_954650	O94964	K0889_HUMAN	hypothetical protein LOC140710 isoform 2	727											0		Myeloproliferative disorder(115;0.00874)				AGCTGTCCCCCGTGCAGGCCT	0.493			NA											6	19					0.000157383	0.000177026	0.00308	1	0
RALGAPB	57148	broad.mit.edu	37	20	37146502	37146502	+	Missense_Mutation	SNP	A	A	G			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr20:37146502A>G	uc002xiw.2	+	9	1533	c.1276A>G	c.(1276-1278)AGT>GGT	p.S426G	RALGAPB_uc010zvz.1_Missense_Mutation_p.S426G|RALGAPB_uc002xix.2_Missense_Mutation_p.S426G|RALGAPB_uc002xiy.1_Missense_Mutation_p.S426G|RALGAPB_uc002xiz.2_Missense_Mutation_p.S204G|RALGAPB_uc002xja.1_Missense_Mutation_p.S153G	NM_020336	NP_065069	Q86X10	RLGPB_HUMAN	Ral GTPase activating protein, beta subunit	426					activation of Ral GTPase activity	intracellular	protein heterodimerization activity|Ral GTPase activator activity			pancreas(1)|skin(1)	2						AAATCAGACTAGTTCAGAACC	0.473			NA											11	59					0	0	0.001855	0	0
L3MBTL	26013	broad.mit.edu	37	20	42157977	42157977	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr20:42157977C>T	uc010zwh.1	+	9	1005	c.959C>T	c.(958-960)CCG>CTG	p.P320L	L3MBTL_uc002xkl.2_Missense_Mutation_p.P252L|L3MBTL_uc002xkm.2_Missense_Mutation_p.P252L|L3MBTL_uc010ggl.2_Missense_Mutation_p.P252L|L3MBTL_uc002xkn.1_Missense_Mutation_p.P11L|L3MBTL_uc002xko.2_5'Flank	NM_015478	NP_056293	Q9Y468	LMBL1_HUMAN	l(3)mbt-like isoform I	252	MBT 1.				chromatin modification|hemopoiesis|negative regulation of transcription, DNA-dependent|regulation of megakaryocyte differentiation|regulation of mitosis	chromatin|condensed chromosome|nucleoplasm	identical protein binding|methylated histone residue binding|nucleosomal histone binding|SAM domain binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Myeloproliferative disorder(115;0.00452)	COAD - Colon adenocarcinoma(18;0.0031)			CCTCAACACCCGTCCATGTAC	0.502			NA											8	19					0	0	0.008291	0	0
KCNS1	3787	broad.mit.edu	37	20	43723683	43723683	+	Missense_Mutation	SNP	A	A	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr20:43723683A>T	uc002xnc.2	-	5	1806	c.1409T>A	c.(1408-1410)CTG>CAG	p.L470Q	KCNS1_uc002xnd.2_Missense_Mutation_p.L470Q	NM_002251	NP_002242	Q96KK3	KCNS1_HUMAN	potassium voltage-gated channel	470	Cytoplasmic (Potential).					voltage-gated potassium channel complex	delayed rectifier potassium channel activity|potassium channel regulator activity|protein binding				0		Myeloproliferative disorder(115;0.0122)				GGCTGCCTCCAGAGCCTTCTG	0.582			NA											28	107					0	0	0.002096	0	0
SLC12A5	57468	broad.mit.edu	37	20	44673655	44673655	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr20:44673655C>A	uc010zxl.1	+	12	1590	c.1514C>A	c.(1513-1515)CCA>CAA	p.P505Q	SLC12A5_uc010zxm.1_Intron|SLC12A5_uc002xrb.2_Missense_Mutation_p.P482Q	NM_001134771	NP_001128243	Q9H2X9	S12A5_HUMAN	solute carrier family 12 (potassium-chloride	505	Helical; (Potential).				potassium ion transport|sodium ion transport	integral to membrane	potassium:chloride symporter activity			ovary(2)|large_intestine(1)|central_nervous_system(1)|skin(1)	5		Myeloproliferative disorder(115;0.0122)			Bumetanide(DB00887)|Potassium Chloride(DB00761)	CTGGCCTGGCCATCTCCATGG	0.607			NA											64	133					3.79363e-24	6.54424e-24	0.00361	1	0
SULF2	55959	broad.mit.edu	37	20	46365579	46365579	+	Missense_Mutation	SNP	T	T	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr20:46365579T>A	uc002xto.2	-	3	613	c.283A>T	c.(283-285)ATC>TTC	p.I95F	SULF2_uc002xtr.2_Missense_Mutation_p.I95F|SULF2_uc002xtq.2_Missense_Mutation_p.I95F|SULF2_uc010ghv.1_Missense_Mutation_p.I95F	NM_018837	NP_061325	Q8IWU5	SULF2_HUMAN	sulfatase 2 isoform a precursor	95					bone development|heparan sulfate proteoglycan metabolic process|kidney development|negative regulation of fibroblast growth factor receptor signaling pathway	cell surface|endoplasmic reticulum|extracellular space|Golgi stack	arylsulfatase activity|calcium ion binding			ovary(2)|breast(2)|pancreas(1)|skin(1)	6						CCAGTGAGGATGGAGGAGCGT	0.607			NA											15	46					0	0	0.00632	0	0
KCNB1	3745	broad.mit.edu	37	20	47990535	47990535	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr20:47990535G>T	uc002xur.1	-	2	1726	c.1562C>A	c.(1561-1563)CCT>CAT	p.P521H	KCNB1_uc002xus.1_Missense_Mutation_p.P521H	NM_004975	NP_004966	Q14721	KCNB1_HUMAN	potassium voltage-gated channel, Shab-related	521	Cytoplasmic (Potential).				energy reserve metabolic process|regulation of insulin secretion	voltage-gated potassium channel complex	protein binding|voltage-gated potassium channel activity			pancreas(1)|skin(1)	2			BRCA - Breast invasive adenocarcinoma(12;0.000405)|COAD - Colon adenocarcinoma(4;0.14)|Colorectal(8;0.166)			CAGGTGCTGAGGACTAGAAGA	0.483			NA											54	169					4.46356e-37	8.12401e-37	0.00361	1	0
PTGIS	5740	broad.mit.edu	37	20	48140725	48140725	+	Missense_Mutation	SNP	G	G	T	rs141132754	byFrequency	TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr20:48140725G>T	uc002xut.2	-	6	779	c.725C>A	c.(724-726)TCC>TAC	p.S242Y	PTGIS_uc010zyi.1_Missense_Mutation_p.S103Y	NM_000961	NP_000952	Q16647	PTGIS_HUMAN	prostaglandin I2 synthase	242					hormone biosynthetic process|prostaglandin biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum lumen|endoplasmic reticulum membrane|integral to membrane	electron carrier activity|heme binding|monooxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen|prostaglandin-I synthase activity			skin(2)|ovary(1)	3			BRCA - Breast invasive adenocarcinoma(12;2.37e-05)|COAD - Colon adenocarcinoma(4;0.14)|Colorectal(8;0.166)		Phenylbutazone(DB00812)	CCTGGCTGGGGATAGCAGCTT	0.602			NA											34	85					1.49673e-21	2.5234e-21	0.00623	1	0
CBLN4	140689	broad.mit.edu	37	20	54579045	54579045	+	Silent	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr20:54579045C>A	uc002xxa.2	-	1	968	c.183G>T	c.(181-183)GGG>GGT	p.G61G		NM_080617	NP_542184	Q9NTU7	CBLN4_HUMAN	cerebellin 4 precursor	61						cell junction|extracellular region|synapse				ovary(3)|pancreas(1)	4			Colorectal(105;0.202)			GGACCGATATCCCCAGCGGGG	0.632			NA											25	44					9.57634e-11	1.3434e-10	0.00333	1	0
MC3R	4159	broad.mit.edu	37	20	54824378	54824378	+	Missense_Mutation	SNP	A	A	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr20:54824378A>T	uc002xxb.2	+	1	591	c.479A>T	c.(478-480)AAG>ATG	p.K160M		NM_019888	NP_063941	P41968	MC3R_HUMAN	melanocortin 3 receptor	197	Cytoplasmic (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|positive regulation of cAMP biosynthetic process	integral to plasma membrane	melanocyte-stimulating hormone receptor activity|neuropeptide binding|protein binding			ovary(2)|breast(2)	4			Colorectal(105;0.202)			ACCGTGAGGAAGGCCCTCACC	0.587			NA											32	84					0	0	0.003755	0	0
TH1L	51497	broad.mit.edu	37	20	57566480	57566480	+	Silent	SNP	C	C	T	rs143108259	byFrequency	TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr20:57566480C>T	uc002yag.2	+	9	1122	c.1095C>T	c.(1093-1095)AGC>AGT	p.S365S	TH1L_uc002yaf.1_RNA|TH1L_uc002yah.2_Silent_p.S365S	NM_198976	NP_945327	Q8IXH7	NELFD_HUMAN	TH1-like protein	365					negative regulation of transcription, DNA-dependent|positive regulation of viral transcription|transcription elongation from RNA polymerase II promoter|viral reproduction	nucleoplasm	protein binding			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3	all_lung(29;0.00711)		Colorectal(105;0.109)			ACGCAGCAAGCGTGGTTGAGA	0.458			NA											12	61					0	0	0.000978	0	0
ZNF831	128611	broad.mit.edu	37	20	57769446	57769446	+	Silent	SNP	G	G	T	rs150212573	by1000genomes	TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr20:57769446G>T	uc002yan.2	+	1	3372	c.3372G>T	c.(3370-3372)CCG>CCT	p.P1124P		NM_178457	NP_848552	Q5JPB2	ZN831_HUMAN	zinc finger protein 831	1124						intracellular	nucleic acid binding|zinc ion binding			skin(13)|ovary(1)	14	all_lung(29;0.0085)					GCCCCGACCCGTGTTCCCCCC	0.667			NA											11	30					4.36969e-10	6.03318e-10	0.001855	1	0
CDH4	1002	broad.mit.edu	37	20	60508126	60508126	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr20:60508126G>A	uc002ybn.1	+	14	2337	c.2323G>A	c.(2323-2325)GAC>AAC	p.D775N	CDH4_uc002ybp.1_Missense_Mutation_p.D701N	NM_001794	NP_001785	P55283	CADH4_HUMAN	cadherin 4, type 1 preproprotein	775	Cytoplasmic (Potential).				adherens junction organization|cell junction assembly		calcium ion binding			lung(3)|ovary(2)|skin(1)	6			BRCA - Breast invasive adenocarcinoma(19;2.36e-08)			CCCCGAGGACGACGTCCGCGA	0.662			NA											29	56					0	0	0.004878	0	0
SLC17A9	63910	broad.mit.edu	37	20	61598070	61598070	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr20:61598070C>T	uc002yea.3	+	12	1317	c.1133C>T	c.(1132-1134)GCC>GTC	p.A378V	SLC17A9_uc002ydz.3_Missense_Mutation_p.A372V|SLC17A9_uc011aap.1_Missense_Mutation_p.A398V	NM_022082	NP_071365	Q9BYT1	S17A9_HUMAN	vesicular nucleotide transporter SLC17A9	378	Helical; (Potential).				exocytosis|transmembrane transport	integral to membrane	transporter activity			ovary(1)|skin(1)	2						GCCAACACAGCCGGGGCCTTG	0.662			NA											28	65					0	0	0.002445	0	0
GMEB2	26205	broad.mit.edu	37	20	62223416	62223416	+	Missense_Mutation	SNP	T	T	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr20:62223416T>A	uc002yfp.1	-	8	1390	c.911A>T	c.(910-912)CAG>CTG	p.Q304L	GMEB2_uc002yfo.1_Missense_Mutation_p.Q226L|GMEB2_uc002yfq.1_Missense_Mutation_p.Q304L	NM_012384	NP_036516	Q9UKD1	GMEB2_HUMAN	glucocorticoid modulatory element binding	304	Potential.				regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|nucleus	DNA binding|metal ion binding				0	all_cancers(38;2.51e-11)|all_epithelial(29;8.27e-13)		Epithelial(9;4.79e-09)|all cancers(9;2.76e-08)|BRCA - Breast invasive adenocarcinoma(10;5.15e-06)|OV - Ovarian serous cystadenocarcinoma(5;0.0114)			GCGGTCCATCTGGCACTTGTG	0.622			NA											26	51					0	0	0.007291	0	0
RTEL1	51750	broad.mit.edu	37	20	62321784	62321784	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr20:62321784G>C	uc002yfu.1	+	26	2746	c.2403G>C	c.(2401-2403)CAG>CAC	p.Q801H	RTEL1_uc011abc.1_RNA|RTEL1_uc002yft.1_Missense_Mutation_p.Q801H|RTEL1_uc011abd.1_Missense_Mutation_p.Q825H|RTEL1_uc011abe.1_Missense_Mutation_p.Q578H|RTEL1_uc002yfw.2_RNA|RTEL1_uc002yfx.1_Missense_Mutation_p.Q46H	NM_016434	NP_057518	Q9NZ71	RTEL1_HUMAN	regulator of telomere elongation helicase 1	801					DNA repair|regulation of double-strand break repair via homologous recombination|telomere maintenance	nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding|iron-sulfur cluster binding|metal ion binding				0	all_cancers(38;6.47e-12)|all_epithelial(29;3.75e-13)		Epithelial(9;1.25e-09)|all cancers(9;5.13e-09)|BRCA - Breast invasive adenocarcinoma(10;7.26e-05)|OV - Ovarian serous cystadenocarcinoma(5;0.00223)|Colorectal(105;0.107)			GCCTGAAGCAGAGGTCCTCAG	0.697			NA											13	30					0	0	0.004007	0	0
TPTE	7179	broad.mit.edu	37	21	10969100	10969100	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr21:10969100C>T	uc002yip.1	-	7	516	c.148G>A	c.(148-150)GCC>ACC	p.A50T	TPTE_uc002yis.1_Intron|TPTE_uc002yiq.1_Intron|TPTE_uc002yir.1_Intron|TPTE_uc010gkv.1_Intron	NM_199261	NP_954870	P56180	TPTE_HUMAN	transmembrane phosphatase with tensin homology	50					signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(2)|lung(1)|breast(1)|skin(1)	5			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		GACACCCGGGCTGCTCCTTTA	0.328			NA											25	134					0	0	0.008361	0	0
KRTAP19-2	337969	broad.mit.edu	37	21	31859618	31859618	+	Missense_Mutation	SNP	T	T	C			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr21:31859618T>C	uc011acy.1	-	1	50	c.50A>G	c.(49-51)TAT>TGT	p.Y17C		NM_181608	NP_853639	Q3LHN2	KR192_HUMAN	keratin associated protein 19-2	17						intermediate filament					0						GCCGCAGCCATAGCCCAGTCT	0.557			NA											5	190					0	0	0.001168	0	0
TIAM1	7074	broad.mit.edu	37	21	32598231	32598231	+	Silent	SNP	G	G	T	rs143707356	byFrequency	TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr21:32598231G>T	uc002yow.1	-	8	2092	c.1620C>A	c.(1618-1620)ACC>ACA	p.T540T	TIAM1_uc011adk.1_Silent_p.T540T|TIAM1_uc011adl.1_Silent_p.T540T|TIAM1_uc002yox.1_Silent_p.T148T	NM_003253	NP_003244	Q13009	TIAM1_HUMAN	T-cell lymphoma invasion and metastasis 1	540	PH 1.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cell-cell junction|cytosol	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			lung(3)|breast(3)|ovary(2)|large_intestine(2)	10						AGTGGATGGCGGTGATCCAGT	0.527			NA											12	20					2.61681e-11	3.72008e-11	0.00245	1	0
MORC3	23515	broad.mit.edu	37	21	37713755	37713755	+	Nonsense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr21:37713755G>T	uc002yvi.2	+	6	743	c.667G>T	c.(667-669)GAG>TAG	p.E223*		NM_015358	NP_056173	Q14149	MORC3_HUMAN	MORC family CW-type zinc finger 3	223					cell aging|maintenance of protein location in nucleus|negative regulation of fibroblast proliferation|peptidyl-serine phosphorylation|protein stabilization	aggresome|intermediate filament cytoskeleton|PML body	ATP binding|zinc ion binding			ovary(2)	2						CAGAATTCCCGAGGATTTAGA	0.368			NA											13	25					0.000151284	0.000170553	0.001855	1	0
UBASH3A	53347	broad.mit.edu	37	21	43833560	43833560	+	Nonsense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr21:43833560G>T	uc002zbe.2	+	5	631	c.595G>T	c.(595-597)GGA>TGA	p.G199*	UBASH3A_uc002zbf.2_Intron|UBASH3A_uc010gpc.2_Intron|UBASH3A_uc010gpd.2_Intron|UBASH3A_uc010gpe.2_Intron	NM_018961	NP_061834	P57075	UBS3A_HUMAN	ubiquitin associated and SH3 domain containing,	199						cytosol|nucleus				ovary(3)	3						CCAGGTGCCTGGACATGGCCC	0.552			NA											13	15					3.41278e-10	4.72955e-10	0.00499	1	0
POTEH	23784	broad.mit.edu	37	22	16287778	16287778	+	Silent	SNP	C	C	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr22:16287778C>T	uc010gqp.2	-	1	160	c.108G>A	c.(106-108)AGG>AGA	p.R36R	POTEH_uc002zlg.1_5'Flank|POTEH_uc002zlh.1_5'Flank|POTEH_uc002zlj.1_5'UTR	NM_001136213	NP_001129685	Q6S545	POTEH_HUMAN	ANKRD26-like family C, member 3	36										skin(1)	1						TGCCGCTCCCCCTGCACCAGG	0.587			NA											60	48					0	0	0.00361	0	0
CCT8L2	150160	broad.mit.edu	37	22	17072823	17072823	+	Nonsense_Mutation	SNP	G	G	T	rs137862002		TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr22:17072823G>T	uc002zlp.1	-	1	878	c.618C>A	c.(616-618)TGC>TGA	p.C206*		NM_014406	NP_055221	Q96SF2	TCPQM_HUMAN	T-complex protein 1	206					cellular protein metabolic process	cytoplasm	anion channel activity|ATP binding|calcium-activated potassium channel activity			ovary(1)	1	all_hematologic(4;0.00567)|Acute lymphoblastic leukemia(84;0.0977)	all_epithelial(15;0.0157)|Lung NSC(13;0.147)|all_lung(157;0.175)				CGGGCAGCGCGCACACCCCAA	0.617			NA											16	70					2.35188e-11	3.34985e-11	0.006122	1	0
DGCR14	8220	broad.mit.edu	37	22	19121734	19121734	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr22:19121734C>A	uc002zou.2	-	10	1443	c.1406G>T	c.(1405-1407)CGG>CTG	p.R469L	DGCR14_uc002zot.2_Missense_Mutation_p.R390L|DGCR14_uc002zov.2_RNA	NM_022719	NP_073210	Q96DF8	DGC14_HUMAN	DiGeorge syndrome critical region protein 14	469					nervous system development	catalytic step 2 spliceosome				ovary(1)	1	Colorectal(54;0.0993)					AGCTTTGCGCCGGGCAGGGAG	0.647			NA											7	25					0.000274275	0.000304364	0.004482	1	0
HIRA	7290	broad.mit.edu	37	22	19379649	19379649	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr22:19379649C>A	uc002zpf.1	-	9	1131	c.911G>T	c.(910-912)AGC>ATC	p.S304I	HIRA_uc011agx.1_Missense_Mutation_p.S170I|HIRA_uc010grn.1_Missense_Mutation_p.S304I|HIRA_uc010gro.1_Missense_Mutation_p.S260I|HIRA_uc010grp.2_RNA	NM_003325	NP_003316	P54198	HIRA_HUMAN	HIR histone cell cycle regulation defective	304	WD 6.				chromatin modification|regulation of transcription from RNA polymerase II promoter	PML body	chromatin binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			ovary(1)	1	Colorectal(54;0.0993)					GCGGTCCTTGCTGCCAACAGC	0.493			NA											14	33					4.7546e-09	6.35229e-09	0.004007	1	0
MMP11	4320	broad.mit.edu	37	22	24124584	24124584	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr22:24124584G>A	uc002zxx.2	+	7	1269	c.1247G>A	c.(1246-1248)CGG>CAG	p.R416Q	MMP11_uc002zxy.2_RNA|MMP11_uc002zxz.2_RNA	NM_005940	NP_005931	P24347	MMP11_HUMAN	matrix metalloproteinase 11 preproprotein	416	Hemopexin-like 3.				collagen catabolic process|multicellular organismal development|proteolysis	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			skin(2)|large_intestine(1)	3		Medulloblastoma(6;9.86e-08)|all_neural(6;0.000318)				CCCAGCACCCGGCGTGTAGAC	0.632			NA											7	31					0	0	0.001984	0	0
MYO18B	84700	broad.mit.edu	37	22	26224872	26224872	+	Silent	SNP	T	T	C			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr22:26224872T>C	uc003abz.1	+	15	3166	c.2916T>C	c.(2914-2916)CAT>CAC	p.H972H	MYO18B_uc003aca.1_Silent_p.H853H|MYO18B_uc010guy.1_Silent_p.H853H|MYO18B_uc010guz.1_Silent_p.H853H|MYO18B_uc011aka.1_Silent_p.H126H|MYO18B_uc011akb.1_Silent_p.H485H	NM_032608	NP_115997	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	972	Myosin head-like.					nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity			ovary(5)|central_nervous_system(3)|large_intestine(2)|breast(2)	12						ACTACGCCCATGAGCGCCTGC	0.617			NA											13	18					0	0	0.003163	0	0
MYO18B	84700	broad.mit.edu	37	22	26351286	26351286	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr22:26351286C>A	uc003abz.1	+	39	6362	c.6112C>A	c.(6112-6114)CTG>ATG	p.L2038M	MYO18B_uc003aca.1_Missense_Mutation_p.L1919M|MYO18B_uc010guy.1_Missense_Mutation_p.L1920M|MYO18B_uc010guz.1_Missense_Mutation_p.L1918M|MYO18B_uc011aka.1_Missense_Mutation_p.L1192M|MYO18B_uc011akb.1_Missense_Mutation_p.L1551M|MYO18B_uc010gva.1_Missense_Mutation_p.L36M	NM_032608	NP_115997	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	2038	Tail.|Potential.					nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity			ovary(5)|central_nervous_system(3)|large_intestine(2)|breast(2)	12						CATGGAAGAGCTGGTGCAGCG	0.637			NA											12	27					3.45872e-05	3.9962e-05	0.004007	1	0
SEZ6L	23544	broad.mit.edu	37	22	26701954	26701954	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr22:26701954G>A	uc003acb.2	+	6	1514	c.1358G>A	c.(1357-1359)GGA>GAA	p.G453E	SEZ6L_uc003acc.2_Missense_Mutation_p.G453E|SEZ6L_uc011akc.1_Missense_Mutation_p.G453E|SEZ6L_uc003acd.2_Missense_Mutation_p.G453E|SEZ6L_uc011akd.1_Missense_Mutation_p.G453E|SEZ6L_uc003ace.2_Missense_Mutation_p.G453E|SEZ6L_uc003acf.1_Missense_Mutation_p.G226E|SEZ6L_uc010gvc.1_Missense_Mutation_p.G226E	NM_021115	NP_066938	Q9BYH1	SE6L1_HUMAN	seizure related 6 homolog (mouse)-like	453	CUB 2.|Extracellular (Potential).					endoplasmic reticulum membrane|integral to membrane				ovary(4)|central_nervous_system(1)|pancreas(1)	6						GCTCCTTGTGGAGGGGCAGTG	0.393			NA											18	59					0	0	0.010504	0	0
RFPL3	10738	broad.mit.edu	37	22	32756382	32756382	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr22:32756382C>A	uc003amj.2	+	2	722	c.517C>A	c.(517-519)CCT>ACT	p.P173T	RFPL3_uc010gwn.2_Missense_Mutation_p.P144T|RFPL3S_uc003amk.2_RNA|RFPL3S_uc003aml.2_RNA	NM_001098535	NP_001092005	O75679	RFPL3_HUMAN	ret finger protein-like 3 isoform 1	173	B30.2/SPRY.						zinc ion binding			ovary(1)	1						CCTGGGCTCCCCTCGCTTTAC	0.562			NA											32	63					8.16904e-11	1.15141e-10	0.007835	1	0
LARGE	9215	broad.mit.edu	37	22	33733749	33733749	+	Silent	SNP	C	C	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr22:33733749C>T	uc003and.3	-	11	1749	c.1170G>A	c.(1168-1170)AAG>AAA	p.K390K	LARGE_uc011amd.1_Silent_p.K189K|LARGE_uc003ane.3_Silent_p.K390K|LARGE_uc010gwp.2_Intron|LARGE_uc011ame.1_Silent_p.K322K|LARGE_uc011amf.1_Silent_p.K390K|LARGE_uc010gwq.1_RNA	NM_004737	NP_004728	O95461	LARGE_HUMAN	like-glycosyltransferase	390	Lumenal (Potential).				glycosphingolipid biosynthetic process|muscle cell homeostasis|N-acetylglucosamine metabolic process|protein glycosylation	integral to Golgi membrane	acetylglucosaminyltransferase activity			ovary(1)|central_nervous_system(1)|skin(1)	3		Lung NSC(1;0.219)				CATGCTTGTTCTTCACCCGGA	0.562	Colon(70;397 1175 4573 19089 45288)		NA											11	45					0	0	0.001368	0	0
RAC2	5880	broad.mit.edu	37	22	37622726	37622726	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr22:37622726C>G	uc003arc.2	-	6	683	c.566G>C	c.(565-567)TGC>TCC	p.C189S		NM_002872	NP_002863	P15153	RAC2_HUMAN	ras-related C3 botulinum toxin substrate 2	189				C->W: Abolishes in vitro prenylation.	axon guidance|platelet activation|regulation of hydrogen peroxide metabolic process|regulation of respiratory burst|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|plasma membrane	GTP binding|GTPase activity|protein binding			breast(2)|central_nervous_system(1)|skin(1)	4						GAGGAGGCTGCAGGCGCGCTT	0.632			NA											8	20					0	0	0.00308	0	0
TRIOBP	11078	broad.mit.edu	37	22	38109231	38109231	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr22:38109231C>T	uc003atr.2	+	5	540	c.269C>T	c.(268-270)TCA>TTA	p.S90L	TRIOBP_uc003atu.2_Intron|TRIOBP_uc003atq.1_Missense_Mutation_p.S90L|TRIOBP_uc003ats.1_Intron	NM_001039141	NP_001034230	Q9H2D6	TARA_HUMAN	TRIO and F-actin binding protein isoform 6	90					actin modification|barbed-end actin filament capping	actin cytoskeleton|cytoplasm|nucleus	actin binding|GTP-Rho binding|myosin II binding|protein binding|ubiquitin protein ligase binding			central_nervous_system(1)	1	Melanoma(58;0.0574)					CCATCCCCCTCAGCAGGGCTC	0.622			NA											5	10					0	0	0.000602	0	0
TRIOBP	11078	broad.mit.edu	37	22	38111769	38111769	+	Splice_Site	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr22:38111769G>T	uc003atr.2	+	6	728	c.457_splice	c.e6-1	p.D153_splice	TRIOBP_uc003atu.2_Splice_Site|TRIOBP_uc003atq.1_Splice_Site_p.D153_splice|TRIOBP_uc003ats.1_Splice_Site	NM_001039141	NP_001034230	Q9H2D6	TARA_HUMAN	TRIO and F-actin binding protein isoform 6						actin modification|barbed-end actin filament capping	actin cytoskeleton|cytoplasm|nucleus	actin binding|GTP-Rho binding|myosin II binding|protein binding|ubiquitin protein ligase binding			central_nervous_system(1)	1	Melanoma(58;0.0574)					TTCTCTGGCAGGACTGGGACA	0.587			NA											7	21					4.68919e-08	6.0898e-08	0.008291	1	0
KCNJ4	3761	broad.mit.edu	37	22	38823370	38823370	+	Silent	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr22:38823370C>A	uc003avs.1	-	2	865	c.768G>T	c.(766-768)GTG>GTT	p.V256V	KCNJ4_uc003avt.1_Silent_p.V256V	NM_004981	NP_004972	P48050	IRK4_HUMAN	potassium inwardly-rectifying channel J4	256	Cytoplasmic (By similarity).				synaptic transmission	basolateral plasma membrane|voltage-gated potassium channel complex	inward rectifier potassium channel activity|PDZ domain binding				0	Melanoma(58;0.0286)					TGATGGGCGACACCAGGAAGA	0.597			NA											22	36					2.24059e-21	3.76471e-21	0.00632	1	0
MGAT3	4248	broad.mit.edu	37	22	39883551	39883551	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr22:39883551C>T	uc003axv.3	+	2	438	c.199C>T	c.(199-201)CCT>TCT	p.P67S	MGAT3_uc010gxy.2_Missense_Mutation_p.P67S	NM_002409	NP_002400	Q09327	MGAT3_HUMAN	mannosyl (beta-1,4-)-glycoprotein	67	Lumenal (Potential).|Pro-rich.				post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	beta-1,4-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity				0	Melanoma(58;0.04)					GCCAGGAGGCCCTGACCTGCT	0.682			NA											31	58					0	0	0.002096	0	0
TEF	7008	broad.mit.edu	37	22	41783641	41783641	+	Silent	SNP	C	C	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr22:41783641C>T	uc003azy.2	+	2	530	c.444C>T	c.(442-444)ATC>ATT	p.I148I	TEF_uc003azx.2_Silent_p.I118I|TEF_uc011apa.1_Silent_p.I153I	NM_003216	NP_003207	Q10587	TEF_HUMAN	thyrotrophic embryonic factor isoform 1	148					rhythmic process	nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1						CCACTGCCATCTTTCAGCCCT	0.602			NA											8	21					0	0	0.004482	0	0
ARFGAP3	26286	broad.mit.edu	37	22	43203164	43203164	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr22:43203164C>G	uc003bdd.2	-	14	1546	c.1326G>C	c.(1324-1326)GAG>GAC	p.E442D	ARFGAP3_uc010gzf.2_Missense_Mutation_p.E398D	NM_014570	NP_055385	Q9NP61	ARFG3_HUMAN	ADP-ribosylation factor GTPase activating	442					intracellular protein transport|protein secretion|regulation of ARF GTPase activity|vesicle-mediated transport	cytosol|Golgi membrane	ARF GTPase activator activity|protein transporter activity|zinc ion binding			breast(1)	1						GGGCCCTGGTCTCATACTAGA	0.502	GBM(58;544 1030 21460 27159 48838)		NA											4	12					0	0	0.009096	0	0
SCUBE1	80274	broad.mit.edu	37	22	43687139	43687139	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr22:43687139C>A	uc003bdt.1	-	4	485	c.397G>T	c.(397-399)GTC>TTC	p.V133F	SCUBE1_uc003bdu.1_Missense_Mutation_p.V133F	NM_173050	NP_766638	Q8IWY4	SCUB1_HUMAN	signal peptide, CUB domain, EGF-like 1	133	EGF-like 3; calcium-binding (Potential).				adult heart development|blood coagulation|endothelial cell differentiation|inflammatory response|post-embryonic development|protein homooligomerization	external side of plasma membrane|extracellular space|extrinsic to plasma membrane	calcium ion binding|identical protein binding|protein heterodimerization activity			central_nervous_system(2)|ovary(1)|lung(1)|skin(1)	5		all_neural(38;0.0414)|Ovarian(80;0.07)				ATGGCATTGACGCAGATCTGC	0.527			NA											15	32					1.50039e-11	2.15148e-11	0.001882	1	0
UPK3A	7380	broad.mit.edu	37	22	45683165	45683165	+	Silent	SNP	G	G	C			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr22:45683165G>C	uc003bfy.2	+	3	327	c.321G>C	c.(319-321)CTG>CTC	p.L107L	UPK3A_uc010gzy.2_Intron	NM_006953	NP_008884	O75631	UPK3A_HUMAN	uroplakin 3A precursor	107	Lumenal (Potential).				epithelial cell differentiation	endoplasmic reticulum membrane|integral to membrane					0		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0178)		CCTTTGACCTGATCCCCTGCA	0.587			NA											12	44					0	0	0.00245	0	0
FBLN1	2192	broad.mit.edu	37	22	45944613	45944613	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr22:45944613G>A	uc003bgj.1	+	13	1709	c.1562G>A	c.(1561-1563)CGC>CAC	p.R521H	FBLN1_uc003bgg.1_Missense_Mutation_p.R521H|FBLN1_uc003bgh.2_Missense_Mutation_p.R521H|FBLN1_uc010gzz.2_Missense_Mutation_p.R559H|FBLN1_uc003bgi.1_Missense_Mutation_p.R521H	NM_006486	NP_006477	P23142	FBLN1_HUMAN	fibulin 1 isoform D	521	EGF-like 8; calcium-binding.			R -> S (in Ref. 6; AAH22497).	interspecies interaction between organisms	extracellular space|soluble fraction	calcium ion binding|extracellular matrix structural constituent|protein binding			ovary(1)|central_nervous_system(1)	2		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0182)		CCCAATGGCCGCAACTGCCAA	0.672			NA											3	59					0	0	0.000602	0	0
PKDREJ	10343	broad.mit.edu	37	22	46652574	46652574	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr22:46652574C>T	uc003bhh.2	-	1	6646	c.6646G>A	c.(6646-6648)GAG>AAG	p.E2216K		NM_006071	NP_006062	Q9NTG1	PKDRE_HUMAN	receptor for egg jelly-like protein precursor	2216	Cytoplasmic (Potential).				acrosome reaction|neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity			breast(3)|ovary(2)	5		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00459)		AACTCAGGCTCATCTTTGGCC	0.478			NA											14	38					0	0	0.003163	0	0
THRB	7068	broad.mit.edu	37	3	24174822	24174822	+	Silent	SNP	C	C	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr3:24174822C>T	uc003ccx.3	-	9	1219	c.870G>A	c.(868-870)TTG>TTA	p.L290L	THRB_uc010hfe.2_Silent_p.L290L|THRB_uc003ccy.3_Silent_p.L290L|THRB_uc003ccz.3_Silent_p.L285L	NM_001128176	NP_001121648	P10828	THB_HUMAN	thyroid hormone receptor, beta	290	Ligand-binding.|Interaction with NR2F6.				regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	enzyme binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|thyroid hormone receptor activity|transcription corepressor activity|zinc ion binding			skin(2)|pancreas(1)	3					Levothyroxine(DB00451)|Liothyronine(DB00279)	AAAACATAGGCAACTTTTTGG	0.373	Melanoma(21;896 1043 15021 37958)		NA											9	23					0	0	0.000978	0	0
EOMES	8320	broad.mit.edu	37	3	27760974	27760974	+	Splice_Site	SNP	T	T	C			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr3:27760974T>C	uc003cdx.2	-	3	1037	c.1037_splice	c.e3-1	p.G346_splice	EOMES_uc003cdy.3_Splice_Site_p.G346_splice|EOMES_uc010hfn.2_Splice_Site_p.G346_splice|EOMES_uc011axc.1_Splice_Site_p.G51_splice	NM_005442	NP_005433	O95936	EOMES_HUMAN	eomesodermin						CD8-positive, alpha-beta T cell differentiation involved in immune response|cell differentiation involved in embryonic placenta development|endoderm formation|mesoderm formation|mesodermal to mesenchymal transition involved in gastrulation|positive regulation of transcription, DNA-dependent	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(3)|breast(1)	4						TTTTGTTGCCTAAGAGAAAAT	0.398			NA											17	22					0	0	0.007413	0	0
ACVR2B	93	broad.mit.edu	37	3	38524706	38524706	+	Silent	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr3:38524706G>T	uc003cif.2	+	11	1446	c.1422G>T	c.(1420-1422)GTG>GTT	p.V474V	ACVR2B_uc003cig.2_Silent_p.V265V	NM_001106	NP_001097	Q13705	AVR2B_HUMAN	activin A receptor, type IIB precursor	474	Cytoplasmic (Potential).|Protein kinase.				activin receptor signaling pathway|anterior/posterior pattern formation|BMP signaling pathway|positive regulation of activin receptor signaling pathway|positive regulation of bone mineralization|positive regulation of osteoblast differentiation|regulation of transcription, DNA-dependent	cell surface|cytoplasm|integral to plasma membrane	activin receptor activity|ATP binding|growth factor binding|metal ion binding|receptor signaling protein serine/threonine kinase activity|transforming growth factor beta receptor activity			lung(1)	1	Medulloblastoma(35;0.163)			KIRC - Kidney renal clear cell carcinoma(284;0.0565)|Kidney(284;0.071)		CGGGCTGTGTGGAGGAGCGGG	0.617			NA											22	59					9.57634e-11	1.3434e-10	0.00333	1	0
CX3CR1	1524	broad.mit.edu	37	3	39307287	39307287	+	Silent	SNP	G	G	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr3:39307287G>A	uc003cjl.2	-	2	806	c.714C>T	c.(712-714)ATC>ATT	p.I238I		NM_001337	NP_001328	P49238	CX3C1_HUMAN	chemokine (C-X3-C motif) receptor 1	238	Helical; Name=6; (Potential).				cell adhesion|cellular defense response|chemotaxis|interspecies interaction between organisms|response to wounding	integral to plasma membrane	chemokine receptor activity			lung(3)	3				KIRC - Kidney renal clear cell carcinoma(284;0.0557)|Kidney(284;0.0699)		GGAAAAACACGATGACCACCA	0.428			NA											9	25					0	0	0.004482	0	0
FYCO1	79443	broad.mit.edu	37	3	46008650	46008650	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr3:46008650G>A	uc003cpb.3	-	8	2382	c.2176C>T	c.(2176-2178)CGG>TGG	p.R726W	FYCO1_uc011bal.1_Missense_Mutation_p.R726W	NM_024513	NP_078789	Q9BQS8	FYCO1_HUMAN	FYVE and coiled-coil domain containing 1	726	Potential.				transport	integral to membrane	metal ion binding|protein binding			central_nervous_system(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.00147)|KIRC - Kidney renal clear cell carcinoma(197;0.0272)|Kidney(197;0.0323)		TCTCTGTGCCGGGCTTCTGCC	0.617			NA											3	71					0	0	0.009096	0	0
GLYCTK	132158	broad.mit.edu	37	3	52326349	52326349	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr3:52326349G>T	uc003ddo.2	+	5	875	c.779G>T	c.(778-780)AGT>ATT	p.S260I	GLYCTK_uc003ddq.2_Missense_Mutation_p.Q201H|GLYCTK_uc003ddm.2_RNA|GLYCTK_uc003ddn.2_Intron|GLYCTK_uc003ddp.1_Missense_Mutation_p.S260I|GLYCTK_uc003ddr.2_5'UTR	NM_145262	NP_660305	Q8IVS8	GLCTK_HUMAN	glycerate kinase isoform 1	260					protein phosphorylation	Golgi apparatus|mitochondrion	ATP binding|glycerate kinase activity|protein binding				0				BRCA - Breast invasive adenocarcinoma(193;3.56e-05)|Kidney(197;0.00171)|KIRC - Kidney renal clear cell carcinoma(197;0.00194)|OV - Ovarian serous cystadenocarcinoma(275;0.235)		ACCGTGGCCAGTTCCCACAAT	0.612			NA											15	19					4.14922e-12	6.06079e-12	0.004007	1	0
PBRM1	55193	broad.mit.edu	37	3	52623229	52623229	+	Nonsense_Mutation	SNP	G	G	C	rs141067977	by1000genomes	TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr3:52623229G>C	uc003des.2	-	18	2834	c.2822C>G	c.(2821-2823)TCA>TGA	p.S941*	PBRM1_uc003dex.2_RNA|PBRM1_uc003deq.2_Nonsense_Mutation_p.S941*|PBRM1_uc003der.2_Nonsense_Mutation_p.S909*|PBRM1_uc003det.2_Nonsense_Mutation_p.S956*|PBRM1_uc003deu.2_Nonsense_Mutation_p.S956*|PBRM1_uc003dev.2_RNA|PBRM1_uc003dew.2_Nonsense_Mutation_p.S941*|PBRM1_uc010hmk.1_Nonsense_Mutation_p.S941*|PBRM1_uc003dey.2_Nonsense_Mutation_p.S941*|PBRM1_uc003dez.1_Nonsense_Mutation_p.S940*|PBRM1_uc003dfb.1_Nonsense_Mutation_p.S853*|PBRM1_uc003dfa.1_Nonsense_Mutation_p.S287*	NM_181042	NP_060635	Q86U86	PB1_HUMAN	polybromo 1 isoform 4	941					chromatin remodeling|mitosis|negative regulation of cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear chromosome	chromatin binding|DNA binding|protein binding			kidney(136)|breast(4)	140				BRCA - Breast invasive adenocarcinoma(193;1.8e-05)|Kidney(197;0.00105)|KIRC - Kidney renal clear cell carcinoma(197;0.00122)|OV - Ovarian serous cystadenocarcinoma(275;0.0613)		ATGTAAGCCTGAGAGGCCTGC	0.428			NA	Mis|N|F|S|D|O		clear cell renal carcinoma|breast								31	42					0	0	0.003755	0	0
PRKCD	5580	broad.mit.edu	37	3	53217201	53217201	+	Silent	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr3:53217201G>T	uc003dgl.2	+	8	989	c.636G>T	c.(634-636)GCG>GCT	p.A212A	PRKCD_uc003dgm.2_Silent_p.A212A|PRKCD_uc010hmt.1_5'Flank	NM_006254	NP_006245	Q05655	KPCD_HUMAN	protein kinase C, delta	212					activation of phospholipase C activity|cellular component disassembly involved in apoptosis|cellular senescence|interferon-gamma-mediated signaling pathway|intracellular signal transduction|mRNA metabolic process|negative regulation of insulin receptor signaling pathway|negative regulation of MAP kinase activity|negative regulation of peptidyl-tyrosine phosphorylation|negative regulation of protein binding|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of ceramide biosynthetic process|positive regulation of glucosylceramide catabolic process|positive regulation of protein dephosphorylation|positive regulation of sphingomyelin catabolic process|protein stabilization|regulation of receptor activity|termination of signal transduction	cytosol|endoplasmic reticulum|nucleoplasm	ATP binding|calcium-independent protein kinase C activity|enzyme activator activity|enzyme binding|insulin receptor substrate binding|metal ion binding|protein C-terminus binding			central_nervous_system(4)|lung(3)|stomach(1)|skin(1)	9		Ovarian(412;0.0728)		OV - Ovarian serous cystadenocarcinoma(275;3.58e-08)|BRCA - Breast invasive adenocarcinoma(193;0.000142)|Kidney(197;0.00153)|KIRC - Kidney renal clear cell carcinoma(197;0.00173)		CTGGCACCGCGGCCAACAGCC	0.612			NA											10	27					4.68919e-08	6.0898e-08	0.008291	1	0
PTPRG	5793	broad.mit.edu	37	3	61989074	61989074	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr3:61989074G>T	uc003dlb.2	+	4	1141	c.422G>T	c.(421-423)GGC>GTC	p.G141V	PTPRG_uc003dlc.2_Missense_Mutation_p.G141V	NM_002841	NP_002832	P23470	PTPRG_HUMAN	protein tyrosine phosphatase, receptor type, G	141	Extracellular (Potential).|Alpha-carbonic anhydrase.				transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	identical protein binding|transmembrane receptor protein tyrosine phosphatase activity			ovary(5)|lung(2)	7				BRCA - Breast invasive adenocarcinoma(55;0.000376)|KIRC - Kidney renal clear cell carcinoma(10;0.0499)|Kidney(10;0.065)		GGTCTACCTGGCAGATTCAAA	0.483			NA											18	43					1.01871e-10	1.42505e-10	0.008871	1	0
PTPRG	5793	broad.mit.edu	37	3	62267340	62267340	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr3:62267340G>A	uc003dlb.2	+	27	4587	c.3868G>A	c.(3868-3870)GAA>AAA	p.E1290K	PTPRG_uc003dlc.2_Missense_Mutation_p.E1261K|PTPRG_uc011bfi.1_Missense_Mutation_p.E536K|uc010hno.2_Intron|uc003dld.3_Intron|uc010hnp.2_Intron|uc003dle.3_Intron	NM_002841	NP_002832	P23470	PTPRG_HUMAN	protein tyrosine phosphatase, receptor type, G	1290	Cytoplasmic (Potential).|Tyrosine-protein phosphatase 2.				transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	identical protein binding|transmembrane receptor protein tyrosine phosphatase activity			ovary(5)|lung(2)	7				BRCA - Breast invasive adenocarcinoma(55;0.000376)|KIRC - Kidney renal clear cell carcinoma(10;0.0499)|Kidney(10;0.065)		CCTCTCTAATGAAGAACAAAT	0.438			NA											26	44					0	0	0.002836	0	0
OR5K3	403277	broad.mit.edu	37	3	98110437	98110437	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr3:98110437C>T	uc011bgw.1	+	1	928	c.928C>T	c.(928-930)CAC>TAC	p.H310Y		NM_001005516	NP_001005516	A6NET4	OR5K3_HUMAN	olfactory receptor, family 5, subfamily K,	310	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						AAAATTTTGTCACATTCTGAA	0.269			NA											25	54					0	0	0.004656	0	0
GPR15	2838	broad.mit.edu	37	3	98251507	98251507	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr3:98251507C>A	uc011bgy.1	+	1	630	c.630C>A	c.(628-630)AGC>AGA	p.S210R		NM_005290	NP_005281	P49685	GPR15_HUMAN	G protein-coupled receptor 15	210	Helical; Name=5; (Potential).					integral to plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			ovary(1)	1		Lung NSC(201;7.93e-06)|all_neural(597;0.00172)|Hepatocellular(537;0.00825)|Myeloproliferative disorder(1037;0.0255)		Lung(72;0.246)		CTTTGTTGAGCATTGTGACCT	0.408			NA											19	62					2.70639e-06	3.26922e-06	0.002299	1	0
CCDC54	84692	broad.mit.edu	37	3	107097331	107097331	+	Silent	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr3:107097331C>A	uc003dwi.1	+	1	1144	c.897C>A	c.(895-897)CCC>CCA	p.P299P		NM_032600	NP_115989	Q8NEL0	CCD54_HUMAN	coiled-coil domain containing 54	299											0						TCACTGGGCCCATTTTGAGCT	0.418			NA											13	30					2.23348e-06	2.71339e-06	0.004007	1	0
DZIP3	9666	broad.mit.edu	37	3	108394644	108394644	+	Nonsense_Mutation	SNP	C	C	G			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr3:108394644C>G	uc003dxd.2	+	25	3127	c.2705C>G	c.(2704-2706)TCA>TGA	p.S902*	DZIP3_uc003dxf.1_Nonsense_Mutation_p.S902*|DZIP3_uc011bhm.1_Nonsense_Mutation_p.S353*	NM_014648	NP_055463	Q86Y13	DZIP3_HUMAN	DAZ interacting protein 3, zinc finger	902					protein polyubiquitination	cytoplasm	polyubiquitin binding|RNA binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2						AACCTAGAATCACTTCAATTA	0.378			NA											8	23					0	0	0.004482	0	0
SLC9A10	285335	broad.mit.edu	37	3	111981885	111981885	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr3:111981885C>A	uc003dyu.2	-	10	1305	c.1083G>T	c.(1081-1083)TGG>TGT	p.W361C	SLC9A10_uc011bhu.1_Intron|SLC9A10_uc010hqc.2_Missense_Mutation_p.W313C	NM_183061	NP_898884	Q4G0N8	S9A10_HUMAN	sperm-specific sodium proton exchanger	361					cell differentiation|multicellular organismal development|sodium ion transport|spermatogenesis	cilium|flagellar membrane|integral to membrane	solute:hydrogen antiporter activity			ovary(3)|breast(2)	5						ATATCCAGCGCCAACTGAACT	0.368			NA											15	50					2.35188e-11	3.34985e-11	0.006122	1	0
CD200R1	131450	broad.mit.edu	37	3	112650004	112650004	+	Missense_Mutation	SNP	A	A	G			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr3:112650004A>G	uc003dzk.1	-	2	315	c.82T>C	c.(82-84)TGT>CGT	p.C28R	CD200R1_uc003dzj.1_Missense_Mutation_p.C51R|CD200R1_uc011bhx.1_Intron|CD200R1_uc003dzl.1_Missense_Mutation_p.C51R|CD200R1_uc003dzm.1_Missense_Mutation_p.C28R	NM_170780	NP_740750	Q8TD46	MO2R1_HUMAN	CD200 receptor 1 isoform d	28					interspecies interaction between organisms|regulation of immune response	extracellular region|integral to membrane|plasma membrane	receptor activity			ovary(2)|pancreas(1)	3						TCATCCATACATAAACTGCTT	0.373			NA											7	44					0	0	0.00308	0	0
ATP6V1A	523	broad.mit.edu	37	3	113524372	113524373	+	Splice_Site	DNP	GG	GG	TT			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr3:113524372_113524373GG>TT	uc003eao.2	+	14	1827	c.1761_splice	c.e14+1	p.K587_splice	ATP6V1A_uc011bik.1_Splice_Site_p.K554_splice	NM_001690	NP_001681	P38606	VATA_HUMAN	ATPase, H+ transporting, lysosomal V1 subunit A						ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|insulin receptor signaling pathway|transferrin transport	cytosol|integral to plasma membrane|proton-transporting V-type ATPase, V1 domain	ATP binding|hydrogen ion transporting ATP synthase activity, rotational mechanism|proton-transporting ATPase activity, rotational mechanism			ovary(2)|skin(1)	3						TGAAATTCAAGGTATATTTTGT	0.262			NA											7	33					0	0	0.004672	0	0
GPR156	165829	broad.mit.edu	37	3	119905592	119905592	+	Silent	SNP	G	G	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr3:119905592G>A	uc011bjf.1	-	5	513	c.513C>T	c.(511-513)GCC>GCT	p.A171A	GPR156_uc011bjg.1_Silent_p.A171A	NM_153002	NP_694547	Q8NFN8	GP156_HUMAN	G protein-coupled receptor 156	171	Helical; (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity|GABA-B receptor activity			ovary(1)|skin(1)	2				GBM - Glioblastoma multiforme(114;0.19)		CCATCAACAGGGCTGCCACCA	0.512			NA											42	115					0	0	0.00361	0	0
POLQ	10721	broad.mit.edu	37	3	121206971	121206971	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr3:121206971G>C	uc003eee.3	-	16	4936	c.4807C>G	c.(4807-4809)CAA>GAA	p.Q1603E	POLQ_uc003eed.2_Missense_Mutation_p.Q775E	NM_199420	NP_955452	O75417	DPOLQ_HUMAN	DNA polymerase theta	1603					DNA repair|DNA replication	nucleoplasm	ATP binding|ATP-dependent helicase activity|damaged DNA binding|DNA-directed DNA polymerase activity|single-stranded DNA-dependent ATPase activity			ovary(4)|breast(3)|lung(2)|upper_aerodigestive_tract(1)|skin(1)	11				GBM - Glioblastoma multiforme(114;0.0915)		TGATCACCTTGGTGGTGCTCA	0.398	Pancreas(152;907 1925 26081 31236 36904)		NA						DNA_polymerases_(catalytic_subunits)					58	184					0	0	0.00361	0	0
PARP15	165631	broad.mit.edu	37	3	122354909	122354909	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr3:122354909C>G	uc003efm.2	+	12	2065	c.1999C>G	c.(1999-2001)CAG>GAG	p.Q667E	PARP15_uc003efn.2_Missense_Mutation_p.Q472E|PARP15_uc003efo.1_Missense_Mutation_p.Q414E|PARP15_uc003efp.1_Missense_Mutation_p.Q433E|PARP15_uc011bjt.1_Missense_Mutation_p.Q364E	NM_001113523	NP_001106995	Q460N3	PAR15_HUMAN	poly (ADP-ribose) polymerase family, member 15	645	PARP catalytic.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	NAD+ ADP-ribosyltransferase activity			lung(3)|upper_aerodigestive_tract(1)|ovary(1)	5				GBM - Glioblastoma multiforme(114;0.0531)		CTTTGATAATCAGGCTTACCC	0.368			NA											9	30					0	0	0.008291	0	0
PARP14	54625	broad.mit.edu	37	3	122446803	122446803	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr3:122446803G>A	uc003efq.3	+	16	5145	c.5086G>A	c.(5086-5088)GGC>AGC	p.G1696S	PARP14_uc010hrk.2_RNA|PARP14_uc003efr.2_Missense_Mutation_p.G1413S	NM_017554	NP_060024	Q460N5	PAR14_HUMAN	poly (ADP-ribose) polymerase family, member 14	1696	PARP catalytic.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	NAD+ ADP-ribosyltransferase activity			ovary(2)|breast(2)|lung(1)|pancreas(1)	6				GBM - Glioblastoma multiforme(114;0.0531)		CAATCGAAATGGCTTTAACCG	0.502			NA											8	20					0	0	0.006214	0	0
ALDH1L1	10840	broad.mit.edu	37	3	125877422	125877423	+	Missense_Mutation	DNP	CC	CC	AA			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr3:125877422_125877423CC>AA	uc003eim.1	-	3	377_378	c.187_188GG>TT	c.(187-189)GGA>TTA	p.G63L	ALDH1L1_uc010hse.1_RNA|ALDH1L1_uc011bki.1_Missense_Mutation_p.G63L|ALDH1L1_uc003eio.2_5'Flank|ALDH1L1_uc010hsf.1_Missense_Mutation_p.G89L|ALDH1L1_uc003eip.1_5'UTR|ALDH1L1_uc011bkj.1_Intron	NM_012190	NP_036322	O75891	AL1L1_HUMAN	aldehyde dehydrogenase 1 family, member L1	63	GART.			G -> A (in Ref. 1; AAC35000).	10-formyltetrahydrofolate catabolic process|biosynthetic process		acyl carrier activity|cofactor binding|formyltetrahydrofolate dehydrogenase activity|hydroxymethyl-, formyl- and related transferase activity|methyltransferase activity			large_intestine(1)|ovary(1)|central_nervous_system(1)|skin(1)	4				GBM - Glioblastoma multiforme(114;0.0462)	Tetrahydrofolic acid(DB00116)	CAAAGCCTGTCCTTTTGCACGC	0.55			NA											28	73					0	0	0.004672	0	0
DNAJB8	165721	broad.mit.edu	37	3	128181664	128181664	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr3:128181664G>T	uc003ekk.1	-	3	2086	c.425C>A	c.(424-426)CCG>CAG	p.P142Q	uc003ekl.1_5'Flank	NM_153330	NP_699161	Q8NHS0	DNJB8_HUMAN	DnaJ homolog, subfamily B, member 8	142					protein folding		heat shock protein binding|unfolded protein binding				0				GBM - Glioblastoma multiforme(114;0.177)		CATGAAGGCCGGAAATTCTCC	0.612			NA											6	17					2.7689e-08	3.62443e-08	0.001984	1	0
Unknown	0	broad.mit.edu	37	3	129140221	129140221	+	Missense_Mutation	SNP	T	T	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr3:129140221T>A	uc003emg.2	-	2	638	c.475A>T	c.(475-477)AGG>TGG	p.R159W		NM_207307	NP_997190			hypothetical protein LOC90288												NA						CTGGTGGTCCTGGTAGTTGCC	0.463			NA											6	16					0	0	0.001168	0	0
COL6A6	131873	broad.mit.edu	37	3	130285953	130285953	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr3:130285953C>A	uc010htl.2	+	4	1721	c.1690C>A	c.(1690-1692)CAC>AAC	p.H564N		NM_001102608	NP_001096078	A6NMZ7	CO6A6_HUMAN	collagen type VI alpha 6 precursor	564	VWFA 3.|Nonhelical region.				axon guidance|cell adhesion	collagen				ovary(6)|central_nervous_system(1)|pancreas(1)	8						GAGAGAAGAGCACATCCGAGT	0.473			NA											33	99					5.71845e-15	8.82089e-15	0.005524	1	0
COL6A6	131873	broad.mit.edu	37	3	130293197	130293197	+	Silent	SNP	G	G	C			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr3:130293197G>C	uc010htl.2	+	7	3406	c.3375G>C	c.(3373-3375)CTG>CTC	p.L1125L		NM_001102608	NP_001096078	A6NMZ7	CO6A6_HUMAN	collagen type VI alpha 6 precursor	1125	Nonhelical region.|VWFA 6.				axon guidance|cell adhesion	collagen				ovary(6)|central_nervous_system(1)|pancreas(1)	8						CGGAAGCCCTGAGACACAGAG	0.567			NA											18	29					0	0	0.00278	0	0
COL6A6	131873	broad.mit.edu	37	3	130380837	130380837	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr3:130380837C>T	uc010htl.2	+	34	6218	c.6187C>T	c.(6187-6189)CAT>TAT	p.H2063Y	COL6A6_uc003eni.3_Missense_Mutation_p.H162Y	NM_001102608	NP_001096078	A6NMZ7	CO6A6_HUMAN	collagen type VI alpha 6 precursor	2063	VWFA 9.|Nonhelical region.				axon guidance|cell adhesion	collagen				ovary(6)|central_nervous_system(1)|pancreas(1)	8						TTTTATTGGTCATGCCTTACA	0.413			NA											4	26					0	0	0.009096	0	0
PIK3R4	30849	broad.mit.edu	37	3	130398210	130398210	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr3:130398210C>A	uc003enj.2	-	20	4607	c.4026G>T	c.(4024-4026)CAG>CAT	p.Q1342H		NM_014602	NP_055417	Q99570	PI3R4_HUMAN	phosphoinositide-3-kinase, regulatory subunit 4	1342	WD 7.				fibroblast growth factor receptor signaling pathway|innate immune response|insulin receptor signaling pathway	cytosol	ATP binding|protein binding|protein serine/threonine kinase activity			ovary(3)|lung(2)|breast(2)|skin(2)|stomach(1)|central_nervous_system(1)|kidney(1)	12						CGATGAAGCCCTGTGTGGTCT	0.423			NA											11	25					7.03913e-09	9.3457e-09	0.001368	1	0
NPHP3	27031	broad.mit.edu	37	3	132403529	132403529	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr3:132403529C>T	uc003epe.1	-	24	3516	c.3439G>A	c.(3439-3441)GAA>AAA	p.E1147K	NPHP3_uc003eoz.1_Missense_Mutation_p.E26K|NPHP3_uc003epd.1_Missense_Mutation_p.E389K	NM_153240	NP_694972	Q7Z494	NPHP3_HUMAN	nephrocystin 3	1147	TPR 8.				maintenance of organ identity|negative regulation of canonical Wnt receptor signaling pathway|photoreceptor cell maintenance|regulation of Wnt receptor signaling pathway, planar cell polarity pathway|Wnt receptor signaling pathway	cilium	protein binding			ovary(1)	1						TGTTTCTTTTCATTGCATAGA	0.428			NA											13	20					0	0	0.001855	0	0
CLSTN2	64084	broad.mit.edu	37	3	140178428	140178428	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr3:140178428C>A	uc003etn.2	+	7	1229	c.1039C>A	c.(1039-1041)CTG>ATG	p.L347M	CLSTN2_uc003etm.2_Missense_Mutation_p.L347M	NM_022131	NP_071414	Q9H4D0	CSTN2_HUMAN	calsyntenin 2 precursor	347	Extracellular (Potential).				homophilic cell adhesion	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|plasma membrane	calcium ion binding			skin(3)|large_intestine(2)|pancreas(1)|central_nervous_system(1)	7						GACTGCAGGACTGCTGGTGGA	0.557	GBM(45;858 913 3709 36904 37282)		NA								HNSCC(16;0.037)			22	48					7.92952e-12	1.14812e-11	0.003954	1	0
CLSTN2	64084	broad.mit.edu	37	3	140282874	140282874	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr3:140282874G>T	uc003etn.2	+	16	2744	c.2554G>T	c.(2554-2556)GTG>TTG	p.V852L		NM_022131	NP_071414	Q9H4D0	CSTN2_HUMAN	calsyntenin 2 precursor	852	Helical; (Potential).				homophilic cell adhesion	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|plasma membrane	calcium ion binding			skin(3)|large_intestine(2)|pancreas(1)|central_nervous_system(1)	7						GGCCATGGGTGTGTACCGGGT	0.537	GBM(45;858 913 3709 36904 37282)		NA								HNSCC(16;0.037)			31	91					8.88839e-20	1.46856e-19	0.002096	1	0
TRIM42	287015	broad.mit.edu	37	3	140406626	140406626	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr3:140406626G>T	uc003eto.1	+	3	1293	c.1102G>T	c.(1102-1104)GAC>TAC	p.D368Y		NM_152616	NP_689829	Q8IWZ5	TRI42_HUMAN	tripartite motif-containing 42	368						intracellular	zinc ion binding			lung(2)|skin(2)|upper_aerodigestive_tract(1)|breast(1)|central_nervous_system(1)	7						CTTTAAAGCTGACAAGGAGGC	0.358			NA											9	19					0.00621372	0.0065484	0.006214	1	0
PLSCR1	5359	broad.mit.edu	37	3	146251271	146251271	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr3:146251271G>A	uc003evx.3	-	3	468	c.80C>T	c.(79-81)CCG>CTG	p.P27L	PLSCR1_uc003evy.3_Missense_Mutation_p.P20L|PLSCR1_uc011bnn.1_Nonsense_Mutation_p.R19*|PLSCR1_uc003evz.3_RNA|PLSCR1_uc003ewa.2_Missense_Mutation_p.P27L	NM_021105	NP_066928	O15162	PLS1_HUMAN	phospholipid scramblase 1	27	Cytoplasmic.				phospholipid scrambling|platelet activation|response to virus	integral to membrane|plasma membrane	calcium ion binding|phospholipid scramblase activity|SH3 domain binding			ovary(2)	2						GAATGCTGTCGGTGGATACTG	0.313			NA											29	93					0	0	0.004878	0	0
IGSF10	285313	broad.mit.edu	37	3	151166319	151166319	+	Nonsense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr3:151166319C>A	uc011bod.1	-	4	1450	c.1450G>T	c.(1450-1452)GAA>TAA	p.E484*		NM_178822	NP_849144	Q6WRI0	IGS10_HUMAN	immunoglobulin superfamily, member 10 precursor	484	Ig-like C2-type 1.				cell differentiation|multicellular organismal development|ossification	extracellular region				skin(7)|ovary(5)|central_nervous_system(1)	13			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			ACAGTATGTTCCAGCTTAGTA	0.483			NA											34	128					1.47197e-15	2.30645e-15	0.007835	1	0
SI	6476	broad.mit.edu	37	3	164785164	164785164	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr3:164785164C>A	uc003fei.2	-	6	661	c.599G>T	c.(598-600)AGC>ATC	p.S200I		NM_001041	NP_001032	P14410	SUIS_HUMAN	sucrase-isomaltase	200	Lumenal.|Isomaltase.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			ovary(7)|upper_aerodigestive_tract(4)|skin(2)|pancreas(1)	14		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	AACTTGGATGCTAAATGGGTT	0.303			NA								HNSCC(35;0.089)			14	51					3.45872e-05	3.9962e-05	0.004007	1	0
SERPINI2	5276	broad.mit.edu	37	3	167164224	167164224	+	Missense_Mutation	SNP	A	A	G			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr3:167164224A>G	uc003fer.1	-	7	1155	c.1097T>C	c.(1096-1098)ATA>ACA	p.I366T	SERPINI2_uc003fes.1_Missense_Mutation_p.I376T|SERPINI2_uc003fet.1_Missense_Mutation_p.I366T	NM_006217	NP_006208	O75830	SPI2_HUMAN	serpin peptidase inhibitor, clade I (pancpin),	366					cellular component movement|regulation of proteolysis	extracellular region	serine-type endopeptidase inhibitor activity			skin(2)|urinary_tract(1)	3						ATGATTTGCTATAAATTGGCT	0.338			NA											25	77					0	0	0.002096	0	0
WDR49	151790	broad.mit.edu	37	3	167240272	167240272	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr3:167240272C>A	uc003fev.1	-	12	1855	c.1549G>T	c.(1549-1551)GCA>TCA	p.A517S	WDR49_uc003feu.1_Missense_Mutation_p.A342S|WDR49_uc011bpd.1_Intron|WDR49_uc003few.1_Intron	NM_178824	NP_849146	Q8IV35	WDR49_HUMAN	WD repeat domain 49	517										large_intestine(1)|ovary(1)|skin(1)	3						CAGTGCTTTGCCTGAAAAAAA	0.204			NA											7	20					1.12685e-05	1.32356e-05	0.004482	1	0
NLGN1	22871	broad.mit.edu	37	3	173996667	173996667	+	Silent	SNP	A	A	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr3:173996667A>T	uc003fio.1	+	6	1299	c.876A>T	c.(874-876)GCA>GCT	p.A292A	NLGN1_uc010hww.1_Silent_p.A332A|NLGN1_uc003fip.1_Silent_p.A292A	NM_014932	NP_055747	Q8N2Q7	NLGN1_HUMAN	neuroligin 1	309	Extracellular (Potential).				calcium-dependent cell-cell adhesion|neuron cell-cell adhesion|neuronal signal transduction|positive regulation of dendritic spine development|positive regulation of excitatory postsynaptic membrane potential|positive regulation of intracellular protein kinase cascade|positive regulation of synaptogenesis|protein targeting|regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|regulation of N-methyl-D-aspartate selective glutamate receptor activity|synapse assembly|synaptic vesicle targeting	cell junction|cell surface|dendrite|integral to plasma membrane|postsynaptic density|postsynaptic membrane	cell adhesion molecule binding|neurexin binding|receptor activity			lung(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)|ovary(1)|pancreas(1)	7	Ovarian(172;0.0025)		LUSC - Lung squamous cell carcinoma(14;5.36e-13)|Lung(28;9.49e-13)			TTCAACGAGCAATAGCTCAAA	0.368			NA											13	20					0	0	0.00245	0	0
NLGN1	22871	broad.mit.edu	37	3	173997229	173997229	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr3:173997229G>T	uc003fio.1	+	6	1861	c.1438G>T	c.(1438-1440)GGT>TGT	p.G480C	NLGN1_uc010hww.1_Missense_Mutation_p.G520C|NLGN1_uc003fip.1_Missense_Mutation_p.G480C	NM_014932	NP_055747	Q8N2Q7	NLGN1_HUMAN	neuroligin 1	497	Extracellular (Potential).				calcium-dependent cell-cell adhesion|neuron cell-cell adhesion|neuronal signal transduction|positive regulation of dendritic spine development|positive regulation of excitatory postsynaptic membrane potential|positive regulation of intracellular protein kinase cascade|positive regulation of synaptogenesis|protein targeting|regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|regulation of N-methyl-D-aspartate selective glutamate receptor activity|synapse assembly|synaptic vesicle targeting	cell junction|cell surface|dendrite|integral to plasma membrane|postsynaptic density|postsynaptic membrane	cell adhesion molecule binding|neurexin binding|receptor activity			lung(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)|ovary(1)|pancreas(1)	7	Ovarian(172;0.0025)		LUSC - Lung squamous cell carcinoma(14;5.36e-13)|Lung(28;9.49e-13)			CTCAAACTTTGGTTCACCTAC	0.488			NA											13	31					6.72482e-11	9.4965e-11	0.003163	1	0
NAALADL2	254827	broad.mit.edu	37	3	175184794	175184794	+	Missense_Mutation	SNP	A	A	G			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr3:175184794A>G	uc003fit.2	+	8	1442	c.1355A>G	c.(1354-1356)CAT>CGT	p.H452R	NAALADL2_uc003fiu.1_Missense_Mutation_p.H445R|NAALADL2_uc010hwy.1_Missense_Mutation_p.H226R|NAALADL2_uc010hwz.1_Missense_Mutation_p.H46R	NM_207015	NP_996898	Q58DX5	NADL2_HUMAN	N-acetylated alpha-linked acidic dipeptidase 2	452	Extracellular (Potential).				proteolysis	integral to membrane	peptidase activity			pancreas(1)	1	Ovarian(172;0.0102)	all_cancers(1;0.0272)|all_epithelial(1;0.0553)	OV - Ovarian serous cystadenocarcinoma(80;9.26e-28)	Colorectal(1;1.66e-10)|COAD - Colon adenocarcinoma(1;2.1e-07)|STAD - Stomach adenocarcinoma(1;0.00261)|READ - Rectum adenocarcinoma(3;0.0284)		GGCAGCCATCATCACACTGCA	0.373			NA											54	146					0	0	0.00361	0	0
PIK3CA	5290	broad.mit.edu	37	3	178919301	178919301	+	Silent	SNP	A	A	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr3:178919301A>T	uc003fjk.2	+	4	943	c.786A>T	c.(784-786)CTA>CTT	p.L262L		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	262	PI3K-RBD.				epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity			breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			AATACTTCCTAGAAAAATATC	0.299	Colon(199;1504 1750 3362 26421 31210 32040)		57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			13	36					0	0	0.003163	0	0
KLHL6	89857	broad.mit.edu	37	3	183273217	183273217	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr3:183273217G>C	uc003flr.2	-	1	283	c.225C>G	c.(223-225)ATC>ATG	p.I75M	KLHL6_uc003fls.1_RNA|KLHL6_uc003flt.1_Missense_Mutation_p.I73M	NM_130446	NP_569713	Q8WZ60	KLHL6_HUMAN	kelch-like 6	75	BTB.									haematopoietic_and_lymphoid_tissue(2)|ovary(1)	3	all_cancers(143;9.2e-12)|Ovarian(172;0.0172)		all cancers(12;1.29e-44)|Epithelial(37;1.24e-38)|LUSC - Lung squamous cell carcinoma(7;2.58e-24)|Lung(8;1.79e-22)|OV - Ovarian serous cystadenocarcinoma(80;2.32e-22)			CCACACACAAGATGACATCTG	0.502			NA											37	77					0	0	0.007835	0	0
PARL	55486	broad.mit.edu	37	3	183602624	183602624	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr3:183602624C>T	uc003fmd.2	-	1	70	c.11G>A	c.(10-12)CGA>CAA	p.R4Q	PARL_uc003fme.2_Missense_Mutation_p.R4Q	NM_018622	NP_061092	Q9H300	PARL_HUMAN	presenilin associated, rhomboid-like isoform 1	4					proteolysis	integral to membrane|mitochondrial inner membrane|nucleus	serine-type endopeptidase activity				0	all_cancers(143;6.55e-10)|Ovarian(172;0.0303)		all cancers(12;2.21e-41)|Epithelial(37;1.34e-36)|OV - Ovarian serous cystadenocarcinoma(80;6.48e-22)			CGCCCAGCCTCGCCACGCCAT	0.697			NA									OREG0015941	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	9	18					0	0	0.000978	0	0
PSMD2	5708	broad.mit.edu	37	3	184025763	184025763	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr3:184025763G>A	uc003fnn.1	+	19	2417	c.2384G>A	c.(2383-2385)GGA>GAA	p.G795E	PSMD2_uc011brj.1_Missense_Mutation_p.G636E|PSMD2_uc011brk.1_Missense_Mutation_p.G665E	NM_002808	NP_002799	Q13200	PSMD2_HUMAN	proteasome 26S non-ATPase subunit 2	795					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|regulation of protein catabolic process|S phase of mitotic cell cycle|viral reproduction	proteasome regulatory particle	enzyme regulator activity|protein binding				0	all_cancers(143;1.54e-10)|Ovarian(172;0.0339)		Epithelial(37;1.53e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)		Bortezomib(DB00188)	GCCGTGGCTGGACTGCTCACT	0.527	Colon(24;313 636 6917 9932 15554)		NA											12	43					0	0	0.00245	0	0
MAP3K13	9175	broad.mit.edu	37	3	185191263	185191263	+	Missense_Mutation	SNP	A	A	G	rs66535452		TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr3:185191263A>G	uc010hyf.2	+	12	2410	c.2144A>G	c.(2143-2145)AAG>AGG	p.K715R	MAP3K13_uc011brt.1_Missense_Mutation_p.K508R|MAP3K13_uc011bru.1_Missense_Mutation_p.K571R|MAP3K13_uc003fpi.2_Missense_Mutation_p.K715R|MAP3K13_uc010hyg.2_Missense_Mutation_p.K405R	NM_004721	NP_004712	O43283	M3K13_HUMAN	mitogen-activated protein kinase kinase kinase	715					activation of MAPKK activity|JNK cascade|positive regulation of NF-kappaB transcription factor activity|protein autophosphorylation	cytoplasm|membrane|membrane fraction	ATP binding|magnesium ion binding|MAP kinase kinase kinase activity|protein homodimerization activity|protein kinase binding			ovary(2)|skin(1)	3	all_cancers(143;7.21e-11)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;1.93e-20)			GAGCCTGACAAGGGCCAAGCT	0.597			NA											23	53					0	0	0.00632	0	0
RTP2	344892	broad.mit.edu	37	3	187419766	187419766	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr3:187419766G>T	uc003fro.1	-	1	580	c.151C>A	c.(151-153)CAC>AAC	p.H51N		NM_001004312	NP_001004312	Q5QGT7	RTP2_HUMAN	receptor transporting protein 2	51	Cytoplasmic (Potential).				protein insertion into membrane	cell surface|integral to membrane|plasma membrane	olfactory receptor binding				0	all_cancers(143;4.06e-12)|Ovarian(172;0.0418)		OV - Ovarian serous cystadenocarcinoma(80;1.76e-18)	GBM - Glioblastoma multiforme(93;0.0515)		CCTGAGGCGTGCTGCTCCAGG	0.622			NA											27	81					4.06085e-26	7.11247e-26	0.007291	1	0
ATP13A5	344905	broad.mit.edu	37	3	193080198	193080198	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr3:193080198C>A	uc011bsq.1	-	5	508	c.508G>T	c.(508-510)GGT>TGT	p.G170C		NM_198505	NP_940907	Q4VNC0	AT135_HUMAN	ATPase type 13A5	170					ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			ovary(5)|skin(4)|large_intestine(2)	11	all_cancers(143;1.08e-08)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(49;5.56e-18)|LUSC - Lung squamous cell carcinoma(58;6.08e-06)|Lung(62;6.49e-06)	GBM - Glioblastoma multiforme(46;0.000307)		CTGGTCAGACCCAATCCAAAT	0.418			NA											29	62					2.68265e-12	3.93545e-12	0.002836	1	0
MUC4	4585	broad.mit.edu	37	3	195516489	195516489	+	Silent	SNP	G	G	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr3:195516489G>A	uc011bto.1	-	2	2422	c.1962C>T	c.(1960-1962)TCC>TCT	p.S654S	MUC4_uc003fvo.2_Intron|MUC4_uc003fvp.2_Intron|MUC4_uc010hzu.1_Silent_p.S536S	NM_018406	NP_060876	Q99102	MUC4_HUMAN	mucin 4 isoform a	659					cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity				0	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		TGGGGGAGACGGACCTCGTGG	0.557			NA											27	78					0	0	0.008361	0	0
RNF168	165918	broad.mit.edu	37	3	196229811	196229811	+	Silent	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr3:196229811C>A	uc003fwq.2	-	1	772	c.234G>T	c.(232-234)ACG>ACT	p.T78T	RNF168_uc010iah.2_5'UTR	NM_152617	NP_689830	Q8IYW5	RN168_HUMAN	ring finger protein 168	78					double-strand break repair|histone H2A K63-linked ubiquitination|positive regulation of DNA repair|response to ionizing radiation	nucleus|ubiquitin ligase complex	chromatin binding|histone binding|ubiquitin binding|ubiquitin-protein ligase activity|zinc ion binding				0	all_cancers(143;1e-08)|Ovarian(172;0.0634)|Breast(254;0.206)		Epithelial(36;5.25e-24)|all cancers(36;5.47e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.76e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00348)		TTTGAATTATCGTCCACAGTT	0.502			NA											22	23					2.98393e-07	3.74439e-07	0.00278	1	0
BDH1	622	broad.mit.edu	37	3	197238927	197238927	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr3:197238927C>A	uc003fxr.2	-	8	1273	c.871G>T	c.(871-873)GGC>TGC	p.G291C	BDH1_uc003fxs.2_Missense_Mutation_p.G291C|BDH1_uc003fxt.2_Missense_Mutation_p.G204C|BDH1_uc003fxu.2_Missense_Mutation_p.G291C	NM_203314	NP_976059	Q02338	BDH_HUMAN	3-hydroxybutyrate dehydrogenase, type 1	291					cellular lipid metabolic process|ketone body biosynthetic process|ketone body catabolic process	mitochondrial matrix	3-hydroxybutyrate dehydrogenase activity			ovary(1)	1	all_cancers(143;3.35e-10)|Ovarian(172;0.0418)|Breast(254;0.0437)	Lung NSC(153;0.118)	Epithelial(36;3.52e-24)|all cancers(36;1.79e-22)|OV - Ovarian serous cystadenocarcinoma(49;2.32e-19)|LUSC - Lung squamous cell carcinoma(58;1.02e-06)|Lung(62;1.34e-06)	GBM - Glioblastoma multiforme(93;0.0977)	NADH(DB00157)	TCTGTGGAGCCACTGCTGCAG	0.577			NA											32	100					2.05212e-20	3.41713e-20	0.005524	1	0
ZNF595	152687	broad.mit.edu	37	4	59449	59449	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr4:59449G>T	uc003fzv.1	+	2	286	c.130G>T	c.(130-132)GGT>TGT	p.G44C	ZNF595_uc003fzu.1_RNA|ZNF718_uc003fzt.3_Missense_Mutation_p.G44C|ZNF595_uc010iay.1_RNA|ZNF595_uc011bus.1_5'UTR|ZNF595_uc011but.1_Intron	NM_182524	NP_872330	Q7Z3I0	Q7Z3I0_HUMAN	zinc finger protein 595	44					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding				0		all_cancers(4;0.0738)|all_epithelial(65;0.139)		Lung(54;0.0654)|Epithelial(2;0.0921)|all cancers(2;0.146)|LUSC - Lung squamous cell carcinoma(95;0.173)		GGTCTCCCTGGGTGAGGATAA	0.413			NA											9	212					0.000978159	0.00106403	0.000978	1	0
ABCA11P	79963	broad.mit.edu	37	4	420315	420315	+	Silent	SNP	G	G	C			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr4:420315G>C	uc003gae.2	-	5	1126	c.591C>G	c.(589-591)CTC>CTG	p.L197L	ABCA11P_uc003gac.2_Silent_p.L146L|ABCA11P_uc003gad.2_RNA|ABCA11P_uc011buv.1_3'UTR|ABCA11P_uc010ibd.1_Silent_p.L197L					RecName: Full=Putative ATP-binding cassette sub-family A member 11;												0						GAGTTCTCCTGAGGGCAGTAC	0.493			NA											16	39					0	0	0.00499	0	0
SH3BP2	6452	broad.mit.edu	37	4	2826361	2826361	+	Silent	SNP	G	G	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr4:2826361G>A	uc003gfi.3	+	4	381	c.261G>A	c.(259-261)GAG>GAA	p.E87E	SH3BP2_uc010icn.2_Silent_p.E87E|SH3BP2_uc011bvp.1_Silent_p.E115E|SH3BP2_uc003gfj.3_Silent_p.E144E|SH3BP2_uc003gfk.3_Silent_p.E87E|SH3BP2_uc003gfl.3_Silent_p.E20E|SH3BP2_uc003gfm.3_5'Flank	NM_001122681	NP_001116153	P78314	3BP2_HUMAN	SH3-domain binding protein 2 isoform a	87	PH.				signal transduction		SH3 domain binding|SH3/SH2 adaptor activity			central_nervous_system(1)	1				UCEC - Uterine corpus endometrioid carcinoma (64;0.164)		CGGCTGAGGAGACCACGTCCA	0.612			NA							Cherubism				22	34					0	0	0.004656	0	0
D4S234E	27065	broad.mit.edu	37	4	4393282	4393282	+	Silent	SNP	C	C	G			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr4:4393282C>G	uc011bvz.1	+	6	1491	c.210C>G	c.(208-210)ACC>ACG	p.T70T	D4S234E_uc011bwa.1_Intron|D4S234E_uc003ghz.2_Silent_p.T70T|D4S234E_uc003gia.2_Silent_p.T70T|D4S234E_uc003gib.2_Silent_p.T70T	NM_014392	NP_055207	P42857	NSG1_HUMAN	brain neuron cytoplasmic protein 1	70	Cytoplasmic (Potential).				dopamine receptor signaling pathway	Golgi membrane|integral to membrane|nucleus	dopamine receptor binding			ovary(1)	1				UCEC - Uterine corpus endometrioid carcinoma (64;0.166)		CTGAGTTCACCGTCAGCATCA	0.532			NA											7	33					0	0	0.001984	0	0
EVC2	132884	broad.mit.edu	37	4	5624387	5624387	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr4:5624387C>A	uc003gij.2	-	14	2432	c.2378G>T	c.(2377-2379)GGG>GTG	p.G793V	EVC2_uc011bwb.1_Missense_Mutation_p.G233V|EVC2_uc003gik.2_Missense_Mutation_p.G713V	NM_147127	NP_667338	Q86UK5	LBN_HUMAN	limbin	793	Potential.					integral to membrane				large_intestine(3)|ovary(2)	5						CCTCTCCTCCCCCTCCAGCTG	0.657			NA											10	36					5.50884e-06	6.54807e-06	0.001368	1	0
JAKMIP1	152789	broad.mit.edu	37	4	6082016	6082016	+	Silent	SNP	C	C	T	rs150623866		TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr4:6082016C>T	uc003giu.3	-	7	1401	c.1125G>A	c.(1123-1125)GCG>GCA	p.A375A	JAKMIP1_uc010idb.1_Silent_p.A375A|JAKMIP1_uc010idc.1_Silent_p.A210A|JAKMIP1_uc010idd.1_Silent_p.A375A|JAKMIP1_uc011bwc.1_Silent_p.A210A|JAKMIP1_uc003giv.3_Silent_p.A375A|JAKMIP1_uc010ide.2_Silent_p.A375A	NM_144720	NP_653321	Q96N16	JKIP1_HUMAN	janus kinase and microtubule interacting protein	375	Mediates interaction with TYK2 and GABBR1.|Potential.		A -> V (in a colorectal cancer sample; somatic mutation).		protein transport	cytoplasm|membrane|microtubule|peripheral to membrane of membrane fraction|ribonucleoprotein complex	GABA receptor binding|RNA binding	p.A375V(1)		large_intestine(1)|pancreas(1)|ovary(1)|skin(1)	4						GCTTCAGAGACGCCTGCGCTG	0.577			NA											8	27					0	0	0.006214	0	0
CLNK	116449	broad.mit.edu	37	4	10566322	10566322	+	Silent	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr4:10566322G>T	uc003gmo.3	-	7	509	c.372C>A	c.(370-372)ACC>ACA	p.T124T	CLNK_uc003gmp.2_Silent_p.T82T	NM_052964	NP_443196	Q7Z7G1	CLNK_HUMAN	mast cell immunoreceptor signal transducer	124					immune response|intracellular signal transduction	intracellular	SH3/SH2 adaptor activity			ovary(1)	1						GTGTGTTCCAGGTCGGCTGTC	0.463	GBM(87;402 1286 6949 13902 35851)		NA											12	31					9.05144e-12	1.30675e-11	0.001855	1	0
CLRN2	645104	broad.mit.edu	37	4	17516969	17516969	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr4:17516969C>G	uc003gpg.1	+	1	182	c.80C>G	c.(79-81)GCC>GGC	p.A27G		NM_001079827	NP_001073296	A0PK11	CLRN2_HUMAN	clarin 2	27	Helical; (Potential).					integral to membrane					0						ATCATCGTTGCCCTGGTAGTG	0.542			NA											9	39					0	0	0.006214	0	0
CLRN2	645104	broad.mit.edu	37	4	17524522	17524522	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr4:17524522C>T	uc003gpg.1	+	2	391	c.289C>T	c.(289-291)CTT>TTT	p.L97F		NM_001079827	NP_001073296	A0PK11	CLRN2_HUMAN	clarin 2	97						integral to membrane					0						CAACGCAGGCCTTCATGTGAT	0.532			NA											38	130					0	0	0.00361	0	0
CLRN2	645104	broad.mit.edu	37	4	17524644	17524644	+	Silent	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr4:17524644C>A	uc003gpg.1	+	2	513	c.411C>A	c.(409-411)ATC>ATA	p.I137I		NM_001079827	NP_001073296	A0PK11	CLRN2_HUMAN	clarin 2	137						integral to membrane					0						CTGGGGGCATCTGCCTATGGA	0.557			NA											9	19					5.50884e-06	6.54807e-06	0.001368	1	0
GBA3	57733	broad.mit.edu	37	4	22749107	22749107	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr4:22749107C>A	uc003gqp.3	+	3	566	c.475C>A	c.(475-477)CAG>AAG	p.Q159K	GBA3_uc010iep.2_Intron|GBA3_uc011bxo.1_Missense_Mutation_p.Q160K	NM_020973	NP_066024	Q9H227	GBA3_HUMAN	cytosolic beta-glucosidase isoform a	159					glycoside catabolic process|glycosylceramide catabolic process	cytosol	beta-galactosidase activity|beta-glucosidase activity|cation binding|glycosylceramidase activity				0						TCGTGTCAAGCAGTGGATCAC	0.428			NA											6	44					3.59834e-05	4.13823e-05	0.001168	1	0
GBA3	57733	broad.mit.edu	37	4	22749243	22749243	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr4:22749243C>G	uc003gqp.3	+	3	702	c.611C>G	c.(610-612)TCC>TGC	p.S204C	GBA3_uc010iep.2_Intron|GBA3_uc011bxo.1_Missense_Mutation_p.S205C	NM_020973	NP_066024	Q9H227	GBA3_HUMAN	cytosolic beta-glucosidase isoform a	204					glycoside catabolic process|glycosylceramide catabolic process	cytosol	beta-galactosidase activity|beta-glucosidase activity|cation binding|glycosylceramidase activity				0						CATGCCAGATCCTGGCACAGC	0.453			NA											25	75					0	0	0.00632	0	0
ANAPC4	29945	broad.mit.edu	37	4	25391839	25391839	+	Silent	SNP	A	A	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr4:25391839A>T	uc003gro.2	+	8	726	c.597A>T	c.(595-597)ACA>ACT	p.T199T	ANAPC4_uc003grp.2_Silent_p.T84T|ANAPC4_uc010iet.1_Silent_p.T8T|ANAPC4_uc010ieu.1_Silent_p.T8T	NM_013367	NP_037499	Q9UJX5	APC4_HUMAN	anaphase-promoting complex subunit 4	199					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|G2/M transition of mitotic cell cycle|mitotic anaphase|mitotic cell cycle spindle assembly checkpoint|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination	anaphase-promoting complex|cytosol|nucleoplasm	protein phosphatase binding|ubiquitin-protein ligase activity			ovary(2)|large_intestine(1)|pancreas(1)|skin(1)	5		Breast(46;0.0503)				CTCGAGTCACAGGGGTAAGAT	0.308			NA											3	48					0	0	0.004672	0	0
SEL1L3	23231	broad.mit.edu	37	4	25835118	25835118	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr4:25835118C>G	uc003gru.3	-	4	1086	c.934G>C	c.(934-936)GAC>CAC	p.D312H		NM_015187	NP_056002	Q68CR1	SE1L3_HUMAN	sel-1 suppressor of lin-12-like 3	312						integral to membrane	binding				0						TCATTAGAGTCAACAAAGTAC	0.368			NA											5	34					0	0	0.001168	0	0
ARAP2	116984	broad.mit.edu	37	4	36160403	36160403	+	Nonsense_Mutation	SNP	G	G	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr4:36160403G>A	uc003gsq.1	-	15	3039	c.2701C>T	c.(2701-2703)CAA>TAA	p.Q901*		NM_015230	NP_056045	Q8WZ64	ARAP2_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH	901	PH 3.				regulation of ARF GTPase activity|small GTPase mediated signal transduction	cytosol	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|zinc ion binding			ovary(1)|pancreas(1)|skin(1)	3						GAAGGAGCTTGATATAAAAAG	0.333			NA											4	23					0	0	0.009096	0	0
TLR1	7096	broad.mit.edu	37	4	38799406	38799406	+	Silent	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr4:38799406C>A	uc003gtl.2	-	4	1321	c.1047G>T	c.(1045-1047)CCG>CCT	p.P349P		NM_003263	NP_003254	Q15399	TLR1_HUMAN	toll-like receptor 1 precursor	349	Extracellular (Potential).				cellular response to triacyl bacterial lipopeptide|detection of triacyl bacterial lipopeptide|inflammatory response|innate immune response|macrophage activation|positive regulation of interleukin-6 biosynthetic process|positive regulation of tumor necrosis factor biosynthetic process	integral to plasma membrane|phagocytic vesicle membrane|Toll-like receptor 1-Toll-like receptor 2 protein complex	protein heterodimerization activity|transmembrane receptor activity			lung(2)|skin(2)|prostate(1)	5						AATGCAGGAACGGGCTAATTT	0.363	GBM(5;216 373 40795 46382)		NA											9	27					4.3838e-07	5.45499e-07	0.001855	1	0
KLB	152831	broad.mit.edu	37	4	39436334	39436334	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr4:39436334C>T	uc003gua.2	+	2	1427	c.1330C>T	c.(1330-1332)CTT>TTT	p.L444F	KLB_uc011byj.1_Missense_Mutation_p.L444F	NM_175737	NP_783864	Q86Z14	KLOTB_HUMAN	klotho beta	444	Extracellular (Potential).|Glycosyl hydrolase-1 1.				carbohydrate metabolic process	integral to membrane|plasma membrane	cation binding|fibroblast growth factor binding|hydrolase activity, hydrolyzing O-glycosyl compounds			skin(1)	1						CAGCCAGGTGCTTCAAGGTTG	0.373			NA											4	22					0	0	0.000602	0	0
DCAF4L1	285429	broad.mit.edu	37	4	41984291	41984291	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr4:41984291C>A	uc003gwk.2	+	1	579	c.482C>A	c.(481-483)GCG>GAG	p.A161E		NM_001029955	NP_001025126	Q3SXM0	DC4L1_HUMAN	WD repeat domain 21B	161										skin(1)	1						CTGCTCCCAGCGTCGCGGTTC	0.572			NA											14	53					1.15088e-07	1.4602e-07	0.004007	1	0
GABRG1	2565	broad.mit.edu	37	4	46043194	46043194	+	Silent	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr4:46043194C>A	uc003gxb.2	-	9	1361	c.1209G>T	c.(1207-1209)GGG>GGT	p.G403G		NM_173536	NP_775807	Q8N1C3	GBRG1_HUMAN	gamma-aminobutyric acid A receptor, gamma 1	403	Cytoplasmic (Probable).				gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity			ovary(2)	2				Lung(65;0.106)|LUSC - Lung squamous cell carcinoma(721;0.23)		AACACTGATACCCATAATCAT	0.428			NA											14	41					4.7546e-09	6.35229e-09	0.004007	1	0
GABRA4	2557	broad.mit.edu	37	4	46930629	46930629	+	Silent	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr4:46930629C>A	uc003gxg.2	-	9	1417	c.1278G>T	c.(1276-1278)CGG>CGT	p.R426R		NM_000809	NP_000800	P48169	GBRA4_HUMAN	gamma-aminobutyric acid A receptor, alpha 4	426	Cytoplasmic (Probable).				gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			ovary(2)|upper_aerodigestive_tract(1)|breast(1)	4					Alprazolam(DB00404)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	CTAAGTAAGACCGAGGTGTGC	0.458	Ovarian(6;283 369 8234 12290 33402)		NA											10	45					2.23348e-06	2.71339e-06	0.004007	1	0
GABRA4	2557	broad.mit.edu	37	4	46976356	46976356	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr4:46976356G>T	uc003gxg.2	-	6	753	c.614C>A	c.(613-615)ACA>AAA	p.T205K		NM_000809	NP_000800	P48169	GBRA4_HUMAN	gamma-aminobutyric acid A receptor, alpha 4	205	Extracellular (Probable).				gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			ovary(2)|upper_aerodigestive_tract(1)|breast(1)	4					Alprazolam(DB00404)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	AGGACCTTTTGTCCAGGTATA	0.408	Ovarian(6;283 369 8234 12290 33402)		NA											9	36					0.000274275	0.000304364	0.004482	1	0
ATP10D	57205	broad.mit.edu	37	4	47589211	47589211	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr4:47589211C>G	uc003gxk.1	+	22	4093	c.3929C>G	c.(3928-3930)GCT>GGT	p.A1310G	ATP10D_uc003gxl.1_Missense_Mutation_p.A558G	NM_020453	NP_065186	Q9P241	AT10D_HUMAN	ATPase, class V, type 10D	1310	Helical; (Potential).				ATP biosynthetic process|cation transport	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(2)|pancreas(1)	3						ACGTCCATTGCTCTTCTGCCC	0.418			NA											15	44					0	0	0.006122	0	0
TEC	7006	broad.mit.edu	37	4	48147115	48147115	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr4:48147115C>A	uc003gxz.2	-	14	1542	c.1451G>T	c.(1450-1452)AGC>ATC	p.S484I		NM_003215	NP_003206	P42680	TEC_HUMAN	tec protein tyrosine kinase	484	Protein kinase.				intracellular protein kinase cascade	cytosol	ATP binding|metal ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding			lung(4)|stomach(1)|central_nervous_system(1)|breast(1)|skin(1)|ovary(1)	9						GTGGATGAAGCTGTTTCTCTC	0.458			NA											14	93					0.000422831	0.000467125	0.004007	1	0
FRYL	285527	broad.mit.edu	37	4	48503687	48503687	+	Missense_Mutation	SNP	A	A	G			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr4:48503687A>G	uc003gyh.1	-	62	9150	c.8545T>C	c.(8545-8547)TAC>CAC	p.Y2849H	FRYL_uc003gye.1_Missense_Mutation_p.Y31H|FRYL_uc003gyf.1_Missense_Mutation_p.Y239H|FRYL_uc003gyg.1_Missense_Mutation_p.Y1539H	NM_015030	NP_055845	O94915	FRYL_HUMAN	furry-like	2849					regulation of transcription, DNA-dependent|transcription, DNA-dependent		protein binding			skin(1)	1						AGTTTACAGTAGGCCTGGAAC	0.299			NA											24	122					0	0	0.002096	0	0
LRRC66	339977	broad.mit.edu	37	4	52863992	52863992	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr4:52863992C>G	uc003gzi.2	-	3	791	c.778G>C	c.(778-780)GAT>CAT	p.D260H		NM_001024611	NP_001019782	Q68CR7	LRC66_HUMAN	leucine rich repeat containing 66	260						integral to membrane				ovary(1)|central_nervous_system(1)|skin(1)	3						GCCACACTATCATCACACTGC	0.393			NA											49	114					0	0	0.00361	0	0
PDGFRA	5156	broad.mit.edu	37	4	55156608	55156608	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr4:55156608G>T	uc003han.3	+	22	3340	c.3009G>T	c.(3007-3009)TGG>TGT	p.W1003C	PDGFRA_uc003haa.2_Missense_Mutation_p.W763C	NM_006206	NP_006197	P16234	PGFRA_HUMAN	platelet-derived growth factor receptor alpha	1003	Cytoplasmic (Potential).				cardiac myofibril assembly|cell activation|luteinization|metanephric glomerular capillary formation|peptidyl-tyrosine phosphorylation|positive regulation of cell migration|positive regulation of DNA replication|positive regulation of fibroblast proliferation|protein autophosphorylation|retina vasculature development in camera-type eye	cytoplasm|integral to plasma membrane|nucleus	ATP binding|platelet-derived growth factor alpha-receptor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|protein homodimerization activity|vascular endothelial growth factor receptor activity			soft_tissue(572)|small_intestine(40)|stomach(16)|lung(16)|central_nervous_system(13)|haematopoietic_and_lymphoid_tissue(7)|skin(3)|ovary(3)|gastrointestinal_tract_(site_indeterminate)(1)|autonomic_ganglia(1)|prostate(1)|bone(1)	674	all_cancers(7;0.000425)|all_lung(4;0.000343)|Lung NSC(11;0.000467)|all_epithelial(27;0.0131)|all_neural(26;0.0209)|Glioma(25;0.08)		GBM - Glioblastoma multiforme(1;4.18e-71)|all cancers(1;4.76e-45)|LUSC - Lung squamous cell carcinoma(32;0.00256)		Becaplermin(DB00102)|Imatinib(DB00619)|Sunitinib(DB01268)	TGAAGGACTGGGAGGGTGGTC	0.542	Pancreas(151;208 1913 7310 23853 37092)		NA	Mis|O|T	FIP1L1	GIST|idiopathic hypereosinophilic syndrome				Gastrointestinal_Stromal_Tumors_Sporadic_Multiple_Primary|Familial_Intestinal_Neurofibromatosis	TSP Lung(21;0.16)			34	63					2.40579e-17	3.89272e-17	0.00623	1	0
PDCL2	132954	broad.mit.edu	37	4	56428761	56428761	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr4:56428761C>G	uc003hbb.2	-	5	484	c.381G>C	c.(379-381)TTG>TTC	p.L127F		NM_152401	NP_689614	Q8N4E4	PDCL2_HUMAN	phosducin-like 2	127											0	Lung NSC(11;0.00256)|Glioma(25;0.08)|all_epithelial(27;0.0863)|all_neural(26;0.101)		LUSC - Lung squamous cell carcinoma(4;1.69e-07)|Lung(4;1.03e-06)|Epithelial(7;0.00669)			GCTGGTTAACCAACAAACACA	0.343			NA											3	13					0	0	0.000602	0	0
KIAA1211	57482	broad.mit.edu	37	4	57182568	57182568	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr4:57182568C>T	uc003hbk.2	+	8	3291	c.2900C>T	c.(2899-2901)CCC>CTC	p.P967L	KIAA1211_uc010iha.2_Missense_Mutation_p.P960L|KIAA1211_uc011bzz.1_Missense_Mutation_p.P877L|KIAA1211_uc003hbm.1_Missense_Mutation_p.P853L	NM_020722	NP_065773	Q6ZU35	K1211_HUMAN	hypothetical protein LOC57482	967	Pro-rich.									ovary(1)|skin(1)	2	Glioma(25;0.08)|all_neural(26;0.101)					GCTCCCAAGCCCACCAGTCAG	0.647			NA											7	17					0	0	0.004482	0	0
SRP72	6731	broad.mit.edu	37	4	57340325	57340325	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr4:57340325G>C	uc003hbv.2	+	4	500	c.460G>C	c.(460-462)GTT>CTT	p.V154L	SRP72_uc010ihe.2_Missense_Mutation_p.V154L|SRP72_uc003hbw.1_5'UTR	NM_006947	NP_008878	O76094	SRP72_HUMAN	signal recognition particle 72kDa	154					response to drug|SRP-dependent cotranslational protein targeting to membrane	cytosol|nucleolus|plasma membrane|signal recognition particle, endoplasmic reticulum targeting	7S RNA binding|signal recognition particle binding			ovary(1)	1	Glioma(25;0.08)|all_neural(26;0.101)					CCTTTCAGCAGTTGTTGCAGC	0.393			NA											6	26					0	0	0.001984	0	0
LPHN3	23284	broad.mit.edu	37	4	62758597	62758597	+	Silent	SNP	T	T	G			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr4:62758597T>G	uc010ihh.2	+	7	1673	c.1500T>G	c.(1498-1500)GCT>GCG	p.A500A	LPHN3_uc003hcq.3_Silent_p.A500A|LPHN3_uc003hcs.1_Silent_p.A329A	NM_015236	NP_056051	Q9HAR2	LPHN3_HUMAN	latrophilin 3 precursor	500	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|sugar binding			lung(15)|ovary(1)|central_nervous_system(1)|pancreas(1)	18						GCTGTGAGGCTGTGGAAGCCC	0.507			NA											4	8					0	0	0.009096	0	0
TECRL	253017	broad.mit.edu	37	4	65147211	65147211	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr4:65147211C>T	uc003hcv.2	-	10	1008	c.899G>A	c.(898-900)TGT>TAT	p.C300Y	TECRL_uc010ihi.2_RNA	NM_001010874	NP_001010874	Q5HYJ1	TECRL_HUMAN	steroid 5 alpha-reductase 2-like 2	300					lipid metabolic process	cytoplasm|integral to membrane	oxidoreductase activity, acting on the CH-CH group of donors				0						GTAGTTAGGACATGAAACCAG	0.323			NA											6	38					0	0	0.00308	0	0
Unknown	0	broad.mit.edu	37	4	69337320	69337320	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr4:69337320C>A	uc003hdz.3	+	5	533	c.469C>A	c.(469-471)CCT>ACT	p.P157T		NM_014058	NP_054777			transmembrane protease, serine 11E												NA						TAAAGTAGATCCTCACTCAGT	0.313			NA											32	64					1.58521e-26	2.78629e-26	0.005524	1	0
C4orf26	152816	broad.mit.edu	37	4	76489342	76489342	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr4:76489342C>A	uc003hip.1	+	2	121	c.86C>A	c.(85-87)ACG>AAG	p.T29K	C4orf26_uc011cbn.1_RNA|C4orf26_uc011cbo.1_Missense_Mutation_p.R44S	NM_178497	NP_848592	Q17RF5	CD026_HUMAN	hypothetical protein LOC152816 precursor	29						extracellular region					0			Lung(101;0.0973)|LUSC - Lung squamous cell carcinoma(112;0.122)			GAGGTATTTACGCCTCCTGGA	0.527			NA											10	28					0.00829132	0.00871937	0.008291	1	0
NKX6-1	4825	broad.mit.edu	37	4	85416970	85416970	+	Missense_Mutation	SNP	T	T	C			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr4:85416970T>C	uc003hpa.1	-	2	704	c.698A>G	c.(697-699)GAC>GGC	p.D233G		NM_006168	NP_006159	P78426	NKX61_HUMAN	NK6 transcription factor related, locus 1	233	Repressor domain (By similarity).				detection of glucose|negative regulation of transcription from RNA polymerase II promoter|organ morphogenesis|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|positive regulation of type B pancreatic cell development|type B pancreatic cell maturation	nucleus					0		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.0013)		TCTCTTCCCGTCTTTGTCCAA	0.483			NA											10	50					0	0	0.001855	0	0
MMRN1	22915	broad.mit.edu	37	4	90874219	90874219	+	Missense_Mutation	SNP	A	A	G			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr4:90874219A>G	uc003hst.2	+	8	3408	c.3337A>G	c.(3337-3339)ATA>GTA	p.I1113V	MMRN1_uc010iku.2_Missense_Mutation_p.I416V|MMRN1_uc011cds.1_Missense_Mutation_p.I855V	NM_007351	NP_031377	Q13201	MMRN1_HUMAN	multimerin 1	1113	C1q.				cell adhesion|platelet activation|platelet degranulation	extracellular region|platelet alpha granule lumen				ovary(4)	4		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;6.96e-05)		TGGAATGACTATACCTGGTCC	0.363			NA											19	45					0	0	0.00278	0	0
GRID2	2895	broad.mit.edu	37	4	94006321	94006321	+	Silent	SNP	T	T	C			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr4:94006321T>C	uc011cdt.1	+	3	678	c.420T>C	c.(418-420)GAT>GAC	p.D140D	GRID2_uc010ikx.2_Silent_p.D140D|GRID2_uc011cdu.1_Intron|GRID2_uc011cdv.1_RNA	NM_001510	NP_001501	O43424	GRID2_HUMAN	glutamate receptor, ionotropic, delta 2	140	Extracellular (Potential).				glutamate signaling pathway	cell junction|integral to plasma membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			ovary(3)|skin(2)|large_intestine(1)	6		Hepatocellular(203;0.114)|all_hematologic(202;0.177)		OV - Ovarian serous cystadenocarcinoma(123;3.22e-06)|LUSC - Lung squamous cell carcinoma(81;0.185)|Lung(65;0.191)	L-Glutamic Acid(DB00142)	ACAGGAATGATGACTACACTC	0.498			NA											16	97					0	0	0.003163	0	0
GRID2	2895	broad.mit.edu	37	4	94547483	94547483	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr4:94547483G>T	uc011cdt.1	+	14	2515	c.2257G>T	c.(2257-2259)GAC>TAC	p.D753Y	GRID2_uc011cdu.1_Missense_Mutation_p.D658Y	NM_001510	NP_001501	O43424	GRID2_HUMAN	glutamate receptor, ionotropic, delta 2	753	Extracellular (Potential).				glutamate signaling pathway	cell junction|integral to plasma membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			ovary(3)|skin(2)|large_intestine(1)	6		Hepatocellular(203;0.114)|all_hematologic(202;0.177)		OV - Ovarian serous cystadenocarcinoma(123;3.22e-06)|LUSC - Lung squamous cell carcinoma(81;0.185)|Lung(65;0.191)	L-Glutamic Acid(DB00142)	GGCTATCAATGACCCAGATTG	0.373			NA											29	64					1.08312e-15	1.70254e-15	0.009535	1	0
SMARCAD1	56916	broad.mit.edu	37	4	95198255	95198255	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr4:95198255C>T	uc003htc.3	+	16	2282	c.2027C>T	c.(2026-2028)CCA>CTA	p.P676L	SMARCAD1_uc003htb.3_Missense_Mutation_p.P676L|SMARCAD1_uc003htd.3_Missense_Mutation_p.P676L|SMARCAD1_uc010ila.2_Missense_Mutation_p.P539L|SMARCAD1_uc011cdw.1_Missense_Mutation_p.P246L	NM_020159	NP_064544	Q9H4L7	SMRCD_HUMAN	SWI/SNF-related, matrix-associated	676	Helicase ATP-binding.				chromatin modification|nucleotide metabolic process|positive regulation of transcription, DNA-dependent|protein homooligomerization|regulation of DNA recombination	nuclear matrix	ATP binding|DNA binding|helicase activity			skin(2)|ovary(1)|breast(1)	4				OV - Ovarian serous cystadenocarcinoma(123;4.33e-08)		TTTGTTATGCCACACATGTTT	0.368			NA											26	81					0	0	0.009535	0	0
SMARCAD1	56916	broad.mit.edu	37	4	95206137	95206137	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr4:95206137G>T	uc003htc.3	+	23	3191	c.2936G>T	c.(2935-2937)AGC>ATC	p.S979I	SMARCAD1_uc003htb.3_Missense_Mutation_p.S981I|SMARCAD1_uc003htd.3_Missense_Mutation_p.S981I|SMARCAD1_uc010ila.2_Missense_Mutation_p.S844I|SMARCAD1_uc011cdw.1_Missense_Mutation_p.S549I	NM_020159	NP_064544	Q9H4L7	SMRCD_HUMAN	SWI/SNF-related, matrix-associated	979	Helicase C-terminal.				chromatin modification|nucleotide metabolic process|positive regulation of transcription, DNA-dependent|protein homooligomerization|regulation of DNA recombination	nuclear matrix	ATP binding|DNA binding|helicase activity			skin(2)|ovary(1)|breast(1)	4				OV - Ovarian serous cystadenocarcinoma(123;4.33e-08)		AAACTAATAAGCCAAGGGACG	0.284			NA											10	42					1.61879e-10	2.25599e-10	0.001368	1	0
ADH7	131	broad.mit.edu	37	4	100349332	100349332	+	Splice_Site	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr4:100349332C>A	uc003huv.1	-	4	395	c.296_splice	c.e4-1	p.G99_splice		NM_000673	NP_000664	P40394	ADH7_HUMAN	class IV alcohol dehydrogenase, mu or sigma						ethanol oxidation|fatty acid omega-oxidation|response to bacterium|response to ethanol|xenobiotic metabolic process	cytosol|soluble fraction	alcohol dehydrogenase activity, zinc-dependent|aldehyde oxidase activity|ethanol binding|receptor antagonist activity|retinol binding|retinol dehydrogenase activity			lung(2)|skin(1)	3				OV - Ovarian serous cystadenocarcinoma(123;1.75e-08)	NADH(DB00157)	ACTTTGTCACCTACAGGAAAA	0.358			NA											20	33					8.81451e-21	1.47437e-20	0.008871	1	0
TET2	54790	broad.mit.edu	37	4	106155435	106155435	+	Silent	SNP	G	G	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr4:106155435G>A	uc003hxk.2	+	3	722	c.336G>A	c.(334-336)TTG>TTA	p.L112L	TET2_uc011cez.1_Silent_p.L133L|TET2_uc003hxj.2_RNA|TET2_uc010ilp.1_Silent_p.L112L|TET2_uc003hxi.1_Silent_p.L112L	NM_001127208	NP_001120680	Q6N021	TET2_HUMAN	tet oncogene family member 2 isoform a	112					cell cycle|myeloid cell differentiation		metal ion binding|methylcytosine dioxygenase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			haematopoietic_and_lymphoid_tissue(732)|pancreas(1)	733		Myeloproliferative disorder(5;0.0393)		OV - Ovarian serous cystadenocarcinoma(123;7.18e-08)		TCAAGAAATTGAAACAAGACC	0.423			NA	Mis N|F		MDS								4	25					0	0	0.009096	0	0
DKK2	27123	broad.mit.edu	37	4	107956673	107956673	+	Missense_Mutation	SNP	A	A	G			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr4:107956673A>G	uc003hyi.2	-	1	781	c.76T>C	c.(76-78)TCA>CCA	p.S26P	DKK2_uc010ilw.1_Intron|DKK2_uc003hyj.1_Missense_Mutation_p.S26P	NM_014421	NP_055236	Q9UBU2	DKK2_HUMAN	dickkopf homolog 2 precursor	26					multicellular organismal development|negative regulation of canonical Wnt receptor signaling pathway|positive regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	extracellular space				ovary(3)|lung(1)|skin(1)	5		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;6.34e-06)		CCGATCTGTGAGCTCTCCACC	0.642			NA											13	111					0	0	0.003163	0	0
COL25A1	84570	broad.mit.edu	37	4	109931531	109931531	+	Nonsense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr4:109931531C>A	uc003hze.1	-	5	952	c.421G>T	c.(421-423)GGA>TGA	p.G141*	COL25A1_uc003hzg.2_Nonsense_Mutation_p.G141*|COL25A1_uc003hzd.2_RNA|COL25A1_uc003hzf.2_5'UTR	NM_198721	NP_942014	Q9BXS0	COPA1_HUMAN	collagen, type XXV, alpha 1 isoform 1	141	Extracellular (Potential).|Collagen-like 1.					collagen|extracellular space	beta-amyloid binding|heparin binding			ovary(2)	2		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.000173)		CCAGGCTGTCCCTGAAATTAA	0.308			NA											8	7					4.1943e-16	6.63503e-16	0.008291	1	0
ALPK1	80216	broad.mit.edu	37	4	113351650	113351650	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr4:113351650G>A	uc003iap.3	+	11	1226	c.947G>A	c.(946-948)TGT>TAT	p.C316Y	ALPK1_uc003ian.3_Missense_Mutation_p.C316Y|ALPK1_uc011cfx.1_Missense_Mutation_p.C238Y|ALPK1_uc003iao.3_Intron|ALPK1_uc010imo.2_Missense_Mutation_p.C144Y	NM_025144	NP_079420	Q96QP1	ALPK1_HUMAN	alpha-kinase 1	316							ATP binding|protein serine/threonine kinase activity			ovary(5)	5		Ovarian(17;0.0446)|Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.00325)		TCAAATGACTGTCCTCCAGAA	0.403			NA											21	50					0	0	0.00632	0	0
ANK2	287	broad.mit.edu	37	4	114179283	114179283	+	Silent	SNP	T	T	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr4:114179283T>A	uc003ibe.3	+	12	1366	c.1266T>A	c.(1264-1266)GCT>GCA	p.A422A	ANK2_uc003ibd.3_Silent_p.A401A|ANK2_uc003ibf.3_Silent_p.A422A|ANK2_uc003ibc.2_Silent_p.A398A|ANK2_uc011cgb.1_Silent_p.A437A	NM_001148	NP_001139	Q01484	ANK2_HUMAN	ankyrin 2 isoform 1	422	ANK 12.				axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding|protein binding			central_nervous_system(7)|ovary(3)|large_intestine(2)|breast(1)|skin(1)	14		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		AATATGGGGCTTCAATCCAAG	0.408			NA											17	30					0	0	0.008871	0	0
NDST4	64579	broad.mit.edu	37	4	115751022	115751022	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr4:115751022C>A	uc003ibu.2	-	13	3102	c.2423G>T	c.(2422-2424)TGT>TTT	p.C808F	NDST4_uc010imw.2_RNA	NM_022569	NP_072091	Q9H3R1	NDST4_HUMAN	heparan sulfate N-deacetylase/N-sulfotransferase	808	Lumenal (Potential).|Heparan sulfate N-sulfotransferase 4.					Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine N-sulfotransferase activity|hydrolase activity			skin(3)|ovary(1)	4		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.000562)		CAGTAATTGACACCAAAAACC	0.348			NA											8	31					1.06961e-07	1.36877e-07	0.00308	1	0
NDST4	64579	broad.mit.edu	37	4	115773937	115773937	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr4:115773937C>T	uc003ibu.2	-	8	2439	c.1760G>A	c.(1759-1761)AGA>AAA	p.R587K	NDST4_uc010imw.2_RNA	NM_022569	NP_072091	Q9H3R1	NDST4_HUMAN	heparan sulfate N-deacetylase/N-sulfotransferase	587	Lumenal (Potential).|Heparan sulfate N-deacetylase 4.					Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine N-sulfotransferase activity|hydrolase activity			skin(3)|ovary(1)	4		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.000562)		AGTTTTCTCTCTGGACCAGAT	0.353			NA											9	21					0	0	0.008291	0	0
BBS7	55212	broad.mit.edu	37	4	122784422	122784422	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr4:122784422C>A	uc003ied.2	-	3	289	c.115G>T	c.(115-117)GAT>TAT	p.D39Y	BBS7_uc003iee.1_Missense_Mutation_p.D39Y|BBS7_uc010inq.1_5'UTR	NM_176824	NP_789794	Q8IWZ6	BBS7_HUMAN	Bardet-Biedl syndrome 7 protein isoform a	39					cilium morphogenesis|digestive tract morphogenesis|fat cell differentiation|heart looping|melanosome transport|pigment granule aggregation in cell center|response to stimulus|visual perception	BBSome|centrosome|cilium membrane	protein binding			ovary(1)	1						CCATCATGATCTCCAATAACC	0.318			NA							Bardet-Biedl_syndrome				32	153					1.32136e-16	2.11275e-16	0.00874	1	0
KIAA1109	84162	broad.mit.edu	37	4	123107222	123107222	+	Silent	SNP	A	A	C			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr4:123107222A>C	uc003ieh.2	+	5	435	c.390A>C	c.(388-390)ACA>ACC	p.T130T	KIAA1109_uc003iei.1_5'UTR	NM_015312	NP_056127	Q2LD37	K1109_HUMAN	fragile site-associated protein	130					regulation of cell growth|regulation of epithelial cell differentiation	integral to membrane|nucleus				ovary(8)|skin(2)|pancreas(1)|central_nervous_system(1)	12						TATACATCACAGTCAATGACT	0.338			NA											10	34					0	0	0.001368	0	0
FAT4	79633	broad.mit.edu	37	4	126238361	126238361	+	Silent	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr4:126238361G>T	uc003ifj.3	+	1	795	c.795G>T	c.(793-795)GTG>GTT	p.V265V		NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	265	Cadherin 3.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18						ACGCGGTTGTGGGTTCCAGCG	0.627			NA									OREG0016317	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	8	15					0.00829132	0.00871937	0.008291	1	0
FAT4	79633	broad.mit.edu	37	4	126411120	126411120	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr4:126411120G>T	uc003ifj.3	+	17	13143	c.13143G>T	c.(13141-13143)AAG>AAT	p.K4381N	FAT4_uc011cgp.1_Missense_Mutation_p.K2622N|FAT4_uc003ifi.1_Missense_Mutation_p.K1858N	NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	4381	Laminin G-like 2.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18						TCAGCGGGAAGCATAGCTTGG	0.493			NA											36	186					1.22674e-20	2.04733e-20	0.00874	1	0
PCDH18	54510	broad.mit.edu	37	4	138451859	138451859	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr4:138451859G>A	uc003ihe.3	-	1	1771	c.1384C>T	c.(1384-1386)CCA>TCA	p.P462S	PCDH18_uc003ihf.3_Missense_Mutation_p.P455S|PCDH18_uc011cgz.1_Intron|PCDH18_uc003ihg.3_Missense_Mutation_p.P242S|PCDH18_uc011cha.1_Intron	NM_019035	NP_061908	Q9HCL0	PCD18_HUMAN	protocadherin 18 precursor	462	Cadherin 4.|Extracellular (Potential).				brain development|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			pancreas(3)|skin(2)	5	all_hematologic(180;0.24)					AAGTGGGGTGGATTGTCATTG	0.418			NA											23	110					0	0	0.003954	0	0
TBC1D9	23158	broad.mit.edu	37	4	141543529	141543529	+	Silent	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr4:141543529C>A	uc010ioj.2	-	21	3893	c.3621G>T	c.(3619-3621)CGG>CGT	p.R1207R		NM_015130	NP_055945	Q6ZT07	TBCD9_HUMAN	TBC1 domain family, member 9 (with GRAM domain)	1207						intracellular	calcium ion binding|Rab GTPase activator activity			ovary(1)	1	all_hematologic(180;0.162)	Medulloblastoma(177;0.00498)				TGGCCCAGTCCCGGTCCAGGC	0.637			NA											6	12					0.00116845	0.00126823	0.001168	1	0
RNF150	57484	broad.mit.edu	37	4	141847210	141847210	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr4:141847210G>T	uc003iio.1	-	5	1562	c.908C>A	c.(907-909)TCC>TAC	p.S303Y	RNF150_uc010iok.1_Missense_Mutation_p.S261Y|RNF150_uc003iip.1_Missense_Mutation_p.S303Y	NM_020724	NP_065775	Q9ULK6	RN150_HUMAN	ring finger protein 150 precursor	303	Cytoplasmic (Potential).|RING-type; atypical.					integral to membrane	zinc ion binding			ovary(1)	1	all_hematologic(180;0.162)					GTCAACACAGGACTTGTGGAA	0.473			NA											7	27					5.18039e-06	6.18734e-06	0.00308	1	0
POU4F2	5458	broad.mit.edu	37	4	147561521	147561521	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr4:147561521G>T	uc003ikv.2	+	2	1039	c.791G>T	c.(790-792)CGC>CTC	p.R264L		NM_004575	NP_004566	Q12837	PO4F2_HUMAN	Brn3b POU domain transcription factor	264	POU-specific.				estrogen receptor signaling pathway|MAPKKK cascade|negative regulation of transcription from RNA polymerase II promoter	nuclear speck	RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription			breast(1)	1	all_hematologic(180;0.151)					TTCGCCGAGCGCTTCAAGCAG	0.697			NA											5	21					1.23904e-05	1.44506e-05	0.000602	1	0
EDNRA	1909	broad.mit.edu	37	4	148463699	148463699	+	Missense_Mutation	SNP	A	A	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr4:148463699A>T	uc003iky.2	+	8	1905	c.1213A>T	c.(1213-1215)ATC>TTC	p.I405F	EDNRA_uc011cid.1_Missense_Mutation_p.I180F|EDNRA_uc010ipf.1_RNA|EDNRA_uc010ipg.1_Missense_Mutation_p.I296F	NM_001957	NP_001948	P25101	EDNRA_HUMAN	endothelin receptor type A isoform a precursor	405	Cytoplasmic (Potential).				activation of adenylate cyclase activity|artery smooth muscle contraction|cell proliferation|glucose transport|respiratory gaseous exchange	integral to plasma membrane	endothelin-A receptor activity|phosphatidylinositol phospholipase C activity			ovary(1)|breast(1)	2	all_hematologic(180;0.151)			GBM - Glioblastoma multiforme(119;0.154)	Bosentan(DB00559)	CGGAACAAGCATCCAGTGGAA	0.532			NA											27	53					0	0	0.00632	0	0
RNF175	285533	broad.mit.edu	37	4	154644586	154644586	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr4:154644586C>G	uc003int.2	-	5	799	c.426G>C	c.(424-426)TTG>TTC	p.L142F	RNF175_uc003inu.1_Missense_Mutation_p.L14F	NM_173662	NP_775933	Q8N4F7	RN175_HUMAN	ring finger protein 175	142						integral to membrane	zinc ion binding			ovary(1)|pancreas(1)	2	all_hematologic(180;0.093)	Renal(120;0.118)				GTTTGTAGATCAAAAGAAACC	0.358			NA											8	10					0	0	0.006214	0	0
DCHS2	54798	broad.mit.edu	37	4	155219643	155219643	+	Silent	SNP	A	A	G			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr4:155219643A>G	uc003inw.2	-	18	4458	c.4458T>C	c.(4456-4458)TCT>TCC	p.S1486S		NM_017639	NP_060109	Q6V1P9	PCD23_HUMAN	dachsous 2 isoform 1	1486	Cadherin 13.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|pancreas(1)	4	all_hematologic(180;0.208)	Renal(120;0.0854)		LUSC - Lung squamous cell carcinoma(193;0.107)		CTTCTCTCACAGAGGACTGGT	0.463			NA											21	87					0	0	0.00333	0	0
GRIA2	2891	broad.mit.edu	37	4	158281203	158281203	+	Silent	SNP	T	T	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr4:158281203T>A	uc003ipm.3	+	13	2658	c.2199T>A	c.(2197-2199)ATT>ATA	p.I733I	GRIA2_uc011cit.1_Silent_p.I686I|GRIA2_uc003ipl.3_Silent_p.I733I|GRIA2_uc003ipk.3_Silent_p.I686I|GRIA2_uc010iqh.1_RNA|GRIA2_uc011ciu.1_Silent_p.I43I|GRIA2_uc011civ.1_RNA|GRIA2_uc011ciw.1_RNA|GRIA2_uc011cix.1_Silent_p.I43I|GRIA2_uc011ciy.1_Silent_p.I43I|GRIA2_uc011ciz.1_RNA	NM_001083619	NP_001077088	P42262	GRIA2_HUMAN	glutamate receptor, ionotropic, AMPA 2 isoform 2	733	Extracellular (Potential).				synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|endocytic vesicle membrane|endoplasmic reticulum membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			central_nervous_system(3)|ovary(1)	4	all_hematologic(180;0.24)	Renal(120;0.0458)		COAD - Colon adenocarcinoma(41;0.0294)	L-Glutamic Acid(DB00142)	ACGAGTACATTGAGCAAAGGA	0.507			NA											16	34					0	0	0.00499	0	0
FSTL5	56884	broad.mit.edu	37	4	162307403	162307403	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr4:162307403G>T	uc003iqh.2	-	16	2476	c.2040C>A	c.(2038-2040)GAC>GAA	p.D680E	FSTL5_uc003iqi.2_Missense_Mutation_p.D679E|FSTL5_uc010iqv.2_Missense_Mutation_p.D670E|uc010iqu.1_RNA	NM_020116	NP_064501	Q8N475	FSTL5_HUMAN	follistatin-like 5 isoform a	680						extracellular region	calcium ion binding			ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|skin(1)	8	all_hematologic(180;0.24)			COAD - Colon adenocarcinoma(41;0.179)		CAGTTACACCGTCCACCATGA	0.498			NA											18	25					2.39187e-15	3.71838e-15	0.008871	1	0
FSTL5	56884	broad.mit.edu	37	4	162577522	162577522	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr4:162577522C>A	uc003iqh.2	-	7	1288	c.852G>T	c.(850-852)AGG>AGT	p.R284S	FSTL5_uc003iqi.2_Missense_Mutation_p.R283S|FSTL5_uc010iqv.2_Missense_Mutation_p.R283S	NM_020116	NP_064501	Q8N475	FSTL5_HUMAN	follistatin-like 5 isoform a	284	Ig-like 1.					extracellular region	calcium ion binding			ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|skin(1)	8	all_hematologic(180;0.24)			COAD - Colon adenocarcinoma(41;0.179)		TAATATTGTTCCTTTTCCAGA	0.348			NA											4	27					1.23904e-05	1.44506e-05	0.000602	1	0
FSTL5	56884	broad.mit.edu	37	4	162680600	162680600	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr4:162680600G>T	uc003iqh.2	-	6	1126	c.690C>A	c.(688-690)GAC>GAA	p.D230E	FSTL5_uc003iqi.2_Missense_Mutation_p.D229E|FSTL5_uc010iqv.2_Missense_Mutation_p.D229E	NM_020116	NP_064501	Q8N475	FSTL5_HUMAN	follistatin-like 5 isoform a	230	2 (Potential).|EF-hand 2.					extracellular region	calcium ion binding			ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|skin(1)	8	all_hematologic(180;0.24)			COAD - Colon adenocarcinoma(41;0.179)		CCAGGTGCTTGTCAGCATTAA	0.333			NA											13	28					4.36969e-10	6.03318e-10	0.001855	1	0
NPY1R	4886	broad.mit.edu	37	4	164246676	164246676	+	Missense_Mutation	SNP	A	A	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr4:164246676A>T	uc003iqm.1	-	3	1200	c.934T>A	c.(934-936)TCC>ACC	p.S312T	NPY1R_uc011cjj.1_Missense_Mutation_p.S69T	NM_000909	NP_000900	P25929	NPY1R_HUMAN	neuropeptide Y receptor Y1	312	Helical; Name=7; (Potential).				inhibition of adenylate cyclase activity by G-protein signaling pathway|outflow tract morphogenesis	integral to plasma membrane	protein binding			lung(1)|pancreas(1)	2	all_hematologic(180;0.166)	Prostate(90;0.0959)|all_neural(102;0.223)				ACACAAGTGGATATCATTGCT	0.418			NA											4	46					0	0	0.009096	0	0
VEGFC	7424	broad.mit.edu	37	4	177608569	177608569	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr4:177608569G>C	uc003ius.1	-	6	1347	c.917C>G	c.(916-918)CCC>CGC	p.P306R		NM_005429	NP_005420	P49767	VEGFC_HUMAN	vascular endothelial growth factor C	306	4 X 16 AA repeats of C-X(10)-C-X-C- X(1,3)-C.|2.				angiogenesis|induction of positive chemotaxis|platelet activation|platelet degranulation|positive regulation of cell division|positive regulation of mast cell chemotaxis|substrate-dependent cell migration|vascular endothelial growth factor receptor signaling pathway	membrane|platelet alpha granule lumen	chemoattractant activity|growth factor activity			lung(5)	5		Breast(14;0.000223)|Renal(120;0.00988)|Prostate(90;0.00996)|Melanoma(52;0.0101)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;1.59e-18)|Epithelial(43;3.68e-16)|OV - Ovarian serous cystadenocarcinoma(60;8.52e-09)|GBM - Glioblastoma multiforme(59;0.000546)|STAD - Stomach adenocarcinoma(60;0.00308)|Colorectal(24;0.025)|COAD - Colon adenocarcinoma(29;0.0359)|LUSC - Lung squamous cell carcinoma(193;0.0397)		TTCTTTGTGGGGTCCACAGCT	0.507			NA											10	66					0	0	0.006214	0	0
RWDD4A	201965	broad.mit.edu	37	4	184567667	184567667	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr4:184567667C>A	uc003ivt.1	-	6	731	c.505G>T	c.(505-507)GGC>TGC	p.G169C	RWDD4A_uc003ivu.1_RNA|RWDD4A_uc003ivv.1_Missense_Mutation_p.G106C|RWDD4A_uc011ckl.1_RNA	NM_152682	NP_689895	Q6NW29	RWDD4_HUMAN	RWD domain containing 4A	169											0		all_lung(41;4.4e-14)|Lung NSC(41;1.03e-13)|Colorectal(36;0.00139)|all_hematologic(60;0.00756)|Hepatocellular(41;0.00826)|Renal(120;0.00988)|Prostate(90;0.0235)|all_neural(102;0.202)		all cancers(43;7.35e-27)|Epithelial(43;1.49e-22)|OV - Ovarian serous cystadenocarcinoma(60;5.76e-10)|GBM - Glioblastoma multiforme(59;5.54e-06)|Colorectal(24;7.92e-06)|STAD - Stomach adenocarcinoma(60;2.35e-05)|COAD - Colon adenocarcinoma(29;6.26e-05)|LUSC - Lung squamous cell carcinoma(40;0.00935)|READ - Rectum adenocarcinoma(43;0.166)		CAGTTCCAGCCTCGAGGAAGT	0.274			NA											34	49					3.43241e-23	5.87342e-23	0.009718	1	0
FAM149A	25854	broad.mit.edu	37	4	187084032	187084032	+	Missense_Mutation	SNP	A	A	C			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr4:187084032A>C	uc003iyt.3	+	9	1342	c.763A>C	c.(763-765)ATG>CTG	p.M255L	FAM149A_uc011cla.1_Missense_Mutation_p.M255L|FAM149A_uc003iyu.3_Missense_Mutation_p.M255L|FAM149A_uc010isl.2_Missense_Mutation_p.M255L|FAM149A_uc011clb.1_Missense_Mutation_p.M255L	NM_015398	NP_056213	A5PLN7	F149A_HUMAN	hypothetical protein LOC25854	546										breast(1)	1		all_cancers(14;4.27e-52)|all_epithelial(14;7.69e-39)|all_lung(41;1.34e-13)|Lung NSC(41;3.58e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.0066)|Hepatocellular(41;0.00886)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|all_neural(102;0.243)		OV - Ovarian serous cystadenocarcinoma(60;1.19e-10)|BRCA - Breast invasive adenocarcinoma(30;1.22e-05)|GBM - Glioblastoma multiforme(59;0.000122)|STAD - Stomach adenocarcinoma(60;0.000288)|LUSC - Lung squamous cell carcinoma(40;0.00241)|READ - Rectum adenocarcinoma(43;0.166)		TTATAGTGACATGAATGGTGT	0.378			NA											20	28					0	0	0.00333	0	0
ADCY2	108	broad.mit.edu	37	5	7626284	7626284	+	Missense_Mutation	SNP	T	T	C			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr5:7626284T>C	uc003jdz.1	+	4	642	c.575T>C	c.(574-576)CTG>CCG	p.L192P		NM_020546	NP_065433	Q08462	ADCY2_HUMAN	adenylate cyclase 2	192	Helical; (Potential).			VWQILANVIIFICGNLAGAY -> GLADPGQCDHFHLWEPG XTN (in Ref. 1; AAP97285).	activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	cytoplasm|dendrite|integral to membrane|plasma membrane	ATP binding|metal ion binding			ovary(5)|pancreas(1)|skin(1)	7						CTTTAGATCCTGGCCAATGTG	0.438			NA											19	108					0	0	0.002299	0	0
CTNND2	1501	broad.mit.edu	37	5	11199587	11199587	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr5:11199587C>G	uc003jfa.1	-	11	2093	c.1948G>C	c.(1948-1950)GAC>CAC	p.D650H	CTNND2_uc010itt.2_Missense_Mutation_p.D559H|CTNND2_uc011cmy.1_Missense_Mutation_p.D313H|CTNND2_uc011cmz.1_Missense_Mutation_p.D217H|CTNND2_uc010itu.1_RNA|CTNND2_uc011cmx.1_Missense_Mutation_p.D217H	NM_001332	NP_001323	Q9UQB3	CTND2_HUMAN	catenin (cadherin-associated protein), delta 2	650	ARM 4.				multicellular organismal development|neuron cell-cell adhesion|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	adherens junction|cytoplasm|nucleus	protein binding			large_intestine(2)|ovary(2)|skin(2)|pancreas(1)|lung(1)	8						ATCTCCAGGTCAGTCGTCTTG	0.428			NA											17	123					0	0	0.00278	0	0
FBXL7	23194	broad.mit.edu	37	5	15936592	15936592	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr5:15936592G>T	uc003jfn.1	+	4	1254	c.773G>T	c.(772-774)CGG>CTG	p.R258L		NM_012304	NP_036436	Q9UJT9	FBXL7_HUMAN	F-box and leucine-rich repeat protein 7	258	LRR 4.				ubiquitin-dependent protein catabolic process	ubiquitin ligase complex	protein binding|ubiquitin-protein ligase activity			ovary(2)|lung(1)	3						AGCTTGACCCGGGAGGCCTCC	0.582			NA											11	22					1.08611e-07	1.38156e-07	0.000978	1	0
MYO10	4651	broad.mit.edu	37	5	16701710	16701710	+	Nonsense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr5:16701710C>A	uc003jft.3	-	25	3262	c.2794G>T	c.(2794-2796)GAG>TAG	p.E932*	MYO10_uc011cnc.1_5'Flank|MYO10_uc011cnd.1_Nonsense_Mutation_p.E289*|MYO10_uc011cne.1_Nonsense_Mutation_p.E289*|MYO10_uc010itx.2_Nonsense_Mutation_p.E555*	NM_012334	NP_036466	Q9HD67	MYO10_HUMAN	myosin X	932	Potential.				axon guidance|signal transduction	myosin complex	actin binding|ATP binding|motor activity			ovary(2)|pancreas(1)	3						CACGCTTCCTCCTCCAGCCTG	0.647			NA											4	10					0.00024832	0.000277424	0.009096	1	0
CDH18	1016	broad.mit.edu	37	5	19838916	19838916	+	Silent	SNP	G	G	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr5:19838916G>A	uc003jgc.2	-	2	557	c.180C>T	c.(178-180)TTC>TTT	p.F60F	CDH18_uc003jgd.2_Silent_p.F60F|CDH18_uc011cnm.1_Silent_p.F60F	NM_004934	NP_004925	Q13634	CAD18_HUMAN	cadherin 18, type 2 preproprotein	60	Extracellular (Potential).|Cadherin 1.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(5)|large_intestine(1)|skin(1)	7	Lung NSC(1;0.00734)|all_lung(1;0.0197)					CTAAAACAAAGAACTGATTCC	0.403			NA											11	22					0	0	0.003163	0	0
CDH12	1010	broad.mit.edu	37	5	21751939	21751939	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr5:21751939G>T	uc010iuc.2	-	12	2750	c.2292C>A	c.(2290-2292)GAC>GAA	p.D764E	CDH12_uc011cno.1_Missense_Mutation_p.D724E|CDH12_uc003jgk.2_Missense_Mutation_p.D764E|uc003jgj.2_Intron	NM_004061	NP_004052	P55289	CAD12_HUMAN	cadherin 12, type 2 preproprotein	764	Cytoplasmic (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)	2						GATAGTCATAGTCCTGGTCGG	0.507			NA								HNSCC(59;0.17)			27	56					9.78485e-24	1.68015e-23	0.002836	1	0
PRDM9	56979	broad.mit.edu	37	5	23526721	23526721	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr5:23526721C>A	uc003jgo.2	+	11	1706	c.1524C>A	c.(1522-1524)AAC>AAA	p.N508K		NM_020227	NP_064612	Q9NQV7	PRDM9_HUMAN	PR domain containing 9	508					meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleoplasm	histone-lysine N-methyltransferase activity|nucleic acid binding|zinc ion binding			ovary(3)|large_intestine(2)|pancreas(1)	6						ATCCAGGGAACACAGGCAAAT	0.428			NA								HNSCC(3;0.000094)			15	41					0.00400662	0.0042678	0.004007	1	0
CDH6	1004	broad.mit.edu	37	5	31317493	31317493	+	Silent	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr5:31317493C>A	uc003jhe.1	+	10	1850	c.1524C>A	c.(1522-1524)ACC>ACA	p.T508T	CDH6_uc003jhd.1_Silent_p.T508T	NM_004932	NP_004923	P55285	CADH6_HUMAN	cadherin 6, type 2 preproprotein	508	Extracellular (Potential).|Cadherin 5.				adherens junction organization|cell junction assembly|homophilic cell adhesion	cytoplasm|integral to membrane|nucleus|plasma membrane	calcium ion binding			ovary(4)|skin(2)|large_intestine(1)	7						TGATTCAGACCCTGCATGCTG	0.393			NA											21	43					1.10923e-09	1.52021e-09	0.00278	1	0
IL7R	3575	broad.mit.edu	37	5	35876369	35876369	+	Silent	SNP	C	C	A	rs139678300		TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr5:35876369C>A	uc003jjs.2	+	8	1250	c.1161C>A	c.(1159-1161)TCC>TCA	p.S387S	IL7R_uc011cop.1_RNA	NM_002185	NP_002176	P16871	IL7RA_HUMAN	interleukin 7 receptor precursor	387	Cytoplasmic (Potential).				immune response|regulation of DNA recombination	extracellular region|integral to membrane	antigen binding|interleukin-7 receptor activity			ovary(3)|breast(1)|skin(1)	5	all_lung(31;0.00015)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Epithelial(62;0.187)|Colorectal(62;0.202)			CTTCCAGGTCCCTAGACTGCA	0.537			NA											5	34					3.59834e-05	4.13823e-05	0.001168	1	0
UGT3A1	133688	broad.mit.edu	37	5	35955804	35955804	+	Missense_Mutation	SNP	T	T	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr5:35955804T>A	uc003jjv.1	-	6	1395	c.1238A>T	c.(1237-1239)AAT>ATT	p.N413I	UGT3A1_uc003jjw.1_RNA|UGT3A1_uc011coq.1_Missense_Mutation_p.N413I|UGT3A1_uc011cor.1_Missense_Mutation_p.N379I	NM_152404	NP_689617	Q6NUS8	UD3A1_HUMAN	UDP glycosyltransferase 3 family, polypeptide A1	413	Extracellular (Potential).					integral to membrane	glucuronosyltransferase activity			ovary(2)|central_nervous_system(1)	3	all_lung(31;0.000197)		Epithelial(62;0.107)|Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			TGTGACCTGATTCAACCGGAT	0.468			NA											29	72					0	0	0.003755	0	0
C9	735	broad.mit.edu	37	5	39342283	39342283	+	Silent	SNP	T	T	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr5:39342283T>A	uc003jlv.3	-	2	182	c.93A>T	c.(91-93)CTA>CTT	p.L31L		NM_001737	NP_001728	P02748	CO9_HUMAN	complement component 9 precursor	31					complement activation, alternative pathway|complement activation, classical pathway|cytolysis|hemolysis by symbiont of host erythrocytes	extracellular region|membrane attack complex					0	all_lung(31;0.000197)	all_neural(839;7.57e-10)|Lung NSC(810;2.62e-08)|Ovarian(839;0.00384)|Breast(839;0.0184)|Myeloproliferative disorder(839;0.0511)	Epithelial(62;0.158)			TGCTTTCTGTTAGCTCTGGGT	0.408			NA											9	28					0	0	0.000978	0	0
DAB2	1601	broad.mit.edu	37	5	39390546	39390546	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr5:39390546C>A	uc003jlx.2	-	5	993	c.462G>T	c.(460-462)CAG>CAT	p.Q154H	DAB2_uc003jlw.2_Missense_Mutation_p.Q154H	NM_001343	NP_001334	P98082	DAB2_HUMAN	disabled homolog 2	154	PID.				cell proliferation|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of protein binding|negative regulation of transcription, DNA-dependent|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|positive regulation of transcription, DNA-dependent|positive regulation of Wnt receptor signaling pathway, planar cell polarity pathway	clathrin coated vesicle membrane|coated pit	protein C-terminus binding			kidney(2)|skin(1)	3	all_lung(31;0.000197)		Epithelial(62;0.137)			TAGAGCTCACCTGTTGCCCGG	0.453			NA											12	51					3.52763e-06	4.24057e-06	0.00499	1	0
PLK2	10769	broad.mit.edu	37	5	57755550	57755550	+	Silent	SNP	C	C	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr5:57755550C>T	uc003jrn.2	-	1	364	c.237G>A	c.(235-237)GGG>GGA	p.G79G	PLK2_uc011cql.1_5'Flank	NM_006622	NP_006613	Q9NYY3	PLK2_HUMAN	polo-like kinase 2	79					positive regulation of I-kappaB kinase/NF-kappaB cascade		ATP binding|protein binding|protein serine/threonine kinase activity|signal transducer activity			ovary(2)|lung(1)|skin(1)	4		all_cancers(5;1.76e-12)|all_epithelial(5;2.09e-13)|all_lung(5;6.64e-05)|Lung NSC(5;0.000127)|Prostate(74;0.055)|Breast(144;0.0602)|Ovarian(174;0.182)		OV - Ovarian serous cystadenocarcinoma(10;7.03e-37)		AGTAGCGCTTCCCAGTCGTGG	0.711			NA											3	11					0	0	0.009096	0	0
HTR1A	3350	broad.mit.edu	37	5	63256719	63256719	+	Nonsense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr5:63256719G>T	uc011cqt.1	-	1	828	c.828C>A	c.(826-828)TGC>TGA	p.C276*		NM_000524	NP_000515	P08908	5HT1A_HUMAN	5-hydroxytryptamine (serotonin) receptor 1A	276	Cytoplasmic (By similarity).				behavior|positive regulation of cell proliferation	integral to plasma membrane	serotonin receptor activity			ovary(2)|pancreas(2)	4		Lung NSC(810;3.55e-06)|Prostate(74;0.0352)|Ovarian(174;0.0545)|Breast(144;0.0575)|Colorectal(97;0.234)		Lung(70;0.105)	Alprenolol(DB00866)|Aripiprazole(DB01238)|Buspirone(DB00490)|Clozapine(DB00363)|Eletriptan(DB00216)|Ergoloid mesylate(DB01049)|Fluvoxamine(DB00176)|Lisuride(DB00589)|Methysergide(DB00247)|Mirtazapine(DB00370)|Pindolol(DB00960)|Propranolol(DB00571)|Quetiapine(DB01224)|Sertraline(DB01104)|Tegaserod(DB01079)|Trazodone(DB00656)|Venlafaxine(DB00285)|Ziprasidone(DB00246)	CGCCATTGGCGCACAGAGCAC	0.657			NA											14	59					9.31168e-06	1.10067e-05	0.001855	1	0
NAIP	4671	broad.mit.edu	37	5	70308510	70308510	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr5:70308510G>T	uc003kar.1	-	4	951	c.233C>A	c.(232-234)CCA>CAA	p.P78Q	NAIP_uc003kat.1_Intron|NAIP_uc011crs.1_Missense_Mutation_p.P78Q|NAIP_uc003kas.1_Intron	NM_004536	NP_004527	Q13075	BIRC1_HUMAN	NLR family, apoptosis inhibitory protein isoform	78	BIR 1.				anti-apoptosis|apoptosis|nervous system development	basolateral plasma membrane|cytoplasm	caspase inhibitor activity|metal ion binding|nucleoside-triphosphatase activity|nucleotide binding			central_nervous_system(1)	1		Lung NSC(167;4.15e-05)|Prostate(74;0.00996)|Ovarian(174;0.0448)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;3.04e-60)|Epithelial(20;7.09e-58)|all cancers(19;1.13e-53)|Lung(70;0.0174)		CATCTCCTGTGGTATCCATGA	0.488			NA											9	44					1.12685e-05	1.32356e-05	0.004482	1	0
RGNEF	64283	broad.mit.edu	37	5	73153602	73153602	+	Nonsense_Mutation	SNP	A	A	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr5:73153602A>T	uc011csq.1	+	14	1923	c.1912A>T	c.(1912-1914)AAG>TAG	p.K638*	RGNEF_uc003kcx.2_Nonsense_Mutation_p.K638*|RGNEF_uc010izf.2_Nonsense_Mutation_p.K638*|RGNEF_uc011csr.1_Nonsense_Mutation_p.K325*	NM_001080479	NP_001073948	Q8N1W1	RGNEF_HUMAN	Rho-guanine nucleotide exchange factor	638					cell differentiation|intracellular signal transduction|regulation of Rho protein signal transduction	cytoplasm|plasma membrane	metal ion binding|Rho guanyl-nucleotide exchange factor activity|RNA binding				0		Lung NSC(167;0.0378)|all_lung(232;0.04)|Ovarian(174;0.0798)		OV - Ovarian serous cystadenocarcinoma(47;1.25e-51)		GAATAAATCAAAGGTAATTAA	0.313			NA											6	11					0	0	0.001984	0	0
SV2C	22987	broad.mit.edu	37	5	75427638	75427638	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr5:75427638G>T	uc003kei.1	+	2	197	c.63G>T	c.(61-63)GAG>GAT	p.E21D		NM_014979	NP_055794	Q496J9	SV2C_HUMAN	synaptic vesicle glycoprotein 2C	21	Interaction with SYT1 (By similarity).|Cytoplasmic (Potential).				neurotransmitter transport	cell junction|integral to membrane|synaptic vesicle membrane	transmembrane transporter activity			skin(1)	1		all_lung(232;0.007)|Lung NSC(167;0.0148)|Ovarian(174;0.0798)|Prostate(461;0.184)		OV - Ovarian serous cystadenocarcinoma(47;1.16e-50)|all cancers(79;7.25e-40)		TTGCCAGAGAGGTGAAGAAAC	0.458			NA											19	31					2.89027e-11	4.10098e-11	0.002299	1	0
ATP6AP1L	92270	broad.mit.edu	37	5	81608634	81608634	+	Silent	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr5:81608634G>T	uc003khv.2	+	9	1661	c.336G>T	c.(334-336)GGG>GGT	p.G112G	ATP6AP1L_uc003khw.2_Silent_p.G112G	NM_001017971	NP_001017971	Q52LC2	VAS1L_HUMAN	ATPase, H+ transporting, lysosomal accessory	112					ATP hydrolysis coupled proton transport	integral to membrane|proton-transporting V-type ATPase, V1 domain	hydrogen ion transporting ATP synthase activity, rotational mechanism|proton-transporting ATPase activity, rotational mechanism				0						CGGATGATGGGTCGAGCCTGT	0.532			NA									OREG0016689	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	19	22					0.00074312	0.000811321	0.006122	1	0
SRFBP1	153443	broad.mit.edu	37	5	121355030	121355030	+	Silent	SNP	C	C	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr5:121355030C>T	uc003kst.1	+	5	418	c.346C>T	c.(346-348)CTA>TTA	p.L116L		NM_152546	NP_689759	Q8NEF9	SRFB1_HUMAN	serum response factor binding protein 1	116	Potential.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	perinuclear region of cytoplasm					0		all_cancers(142;0.0124)|Prostate(80;0.0322)	KIRC - Kidney renal clear cell carcinoma(527;0.206)	OV - Ovarian serous cystadenocarcinoma(64;0.000227)|Epithelial(69;0.000365)|all cancers(49;0.00517)		GATAGATGTGCTAAAAGGTAT	0.313			NA											19	40					0	0	0.010504	0	0
ADAMTS19	171019	broad.mit.edu	37	5	128797435	128797435	+	Silent	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr5:128797435C>A	uc003kvb.1	+	2	714	c.714C>A	c.(712-714)ACC>ACA	p.T238T	ADAMTS19_uc003kvc.1_RNA	NM_133638	NP_598377	Q8TE59	ATS19_HUMAN	ADAM metallopeptidase with thrombospondin type 1	238					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(5)|breast(2)|lung(1)|skin(1)	9		all_cancers(142;0.0148)|Prostate(80;0.0494)|Breast(839;0.238)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	OV - Ovarian serous cystadenocarcinoma(64;0.222)		CTTTCAGCACCTGTGGAGGTG	0.622			NA											18	30					2.39187e-15	3.71838e-15	0.008871	1	0
SPOCK1	6695	broad.mit.edu	37	5	136314451	136314451	+	Silent	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr5:136314451C>A	uc003lbo.2	-	10	1403	c.1212G>T	c.(1210-1212)CTG>CTT	p.L404L	SPOCK1_uc003lbp.2_Silent_p.L404L	NM_004598	NP_004589	Q08629	TICN1_HUMAN	sparc/osteonectin, cwcv and kazal-like domains	404					cell adhesion|cell proliferation|cellular component movement|nervous system development|signal transduction	proteinaceous extracellular matrix	calcium ion binding			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			CCTTTGGTCCCAGCTCCCGTT	0.522			NA											23	43					2.89027e-11	4.10098e-11	0.002299	1	0
PSD2	84249	broad.mit.edu	37	5	139219657	139219657	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr5:139219657G>T	uc003leu.1	+	14	2219	c.2014G>T	c.(2014-2016)GCG>TCG	p.A672S		NM_032289	NP_115665	Q9BQI7	PSD2_HUMAN	pleckstrin and Sec7 domain containing 2	672	Potential.				regulation of ARF protein signal transduction	cytoplasm|integral to membrane	ARF guanyl-nucleotide exchange factor activity			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCAGCTGACTGCGGAGCTGGC	0.562			NA											15	34					2.23348e-06	2.71339e-06	0.004007	1	0
PCDHA3	56145	broad.mit.edu	37	5	140181070	140181070	+	Nonsense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr5:140181070C>A	uc003lhf.2	+	1	288	c.288C>A	c.(286-288)TGC>TGA	p.C96*	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA2_uc011czy.1_Intron|PCDHA3_uc011czz.1_Nonsense_Mutation_p.C96*	NM_018906	NP_061729	Q9Y5H8	PCDA3_HUMAN	protocadherin alpha 3 isoform 1 precursor	96	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(6)|skin(2)	8			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGGAACTGTGCGGGCGGAGCG	0.552			NA											59	96					1.41595e-48	2.62861e-48	0.00361	1	0
PCDHA3	56145	broad.mit.edu	37	5	140181946	140181946	+	Silent	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr5:140181946G>T	uc003lhf.2	+	1	1164	c.1164G>T	c.(1162-1164)TCG>TCT	p.S388S	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA2_uc011czy.1_Intron|PCDHA3_uc011czz.1_Silent_p.S388S	NM_018906	NP_061729	Q9Y5H8	PCDA3_HUMAN	protocadherin alpha 3 isoform 1 precursor	388	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(6)|skin(2)	8			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCACCTGCTCGCTGACGCCCC	0.552			NA											40	49					1.22674e-20	2.04733e-20	0.00874	1	0
PCDHA9	9752	broad.mit.edu	37	5	140228219	140228219	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr5:140228219C>T	uc003lhu.2	+	1	863	c.139C>T	c.(139-141)CGC>TGC	p.R47C	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lht.1_Missense_Mutation_p.R47C	NM_031857	NP_114063	Q9Y5H5	PCDA9_HUMAN	protocadherin alpha 9 isoform 1 precursor	47	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			large_intestine(2)|ovary(2)|skin(1)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTTCGTGGGCCGCATCGCGCA	0.647	Melanoma(55;1800 1972 14909)		NA											22	45					0	0	0.004656	0	0
PCDHA9	9752	broad.mit.edu	37	5	140229017	140229017	+	Missense_Mutation	SNP	A	A	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr5:140229017A>T	uc003lhu.2	+	1	1661	c.937A>T	c.(937-939)AGT>TGT	p.S313C	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lht.1_Missense_Mutation_p.S313C	NM_031857	NP_114063	Q9Y5H5	PCDA9_HUMAN	protocadherin alpha 9 isoform 1 precursor	313	Cadherin 3.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			large_intestine(2)|ovary(2)|skin(1)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TTTTGAAGAAAGTAGAGCACA	0.453	Melanoma(55;1800 1972 14909)		NA											8	11					0	0	0.004007	0	0
PCDHA13	56136	broad.mit.edu	37	5	140262681	140262681	+	Missense_Mutation	SNP	T	T	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr5:140262681T>A	uc003lif.2	+	1	828	c.828T>A	c.(826-828)GAT>GAA	p.D276E	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc003lia.2_Intron|PCDHA12_uc003lic.2_Intron|PCDHA13_uc003lie.1_Missense_Mutation_p.D276E|PCDHA13_uc003lid.2_Missense_Mutation_p.D276E	NM_018904	NP_061727	Q9Y5I0	PCDAD_HUMAN	protocadherin alpha 13 isoform 1 precursor	276	Cadherin 3.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|skin(2)|central_nervous_system(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CAAATGGAGATATAGTTTACT	0.388	Melanoma(147;1739 1852 5500 27947 37288)		NA											17	36					0	0	0.006122	0	0
PCDHB5	26167	broad.mit.edu	37	5	140517283	140517283	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr5:140517283G>C	uc003liq.2	+	1	2484	c.2267G>C	c.(2266-2268)GGA>GCA	p.G756A		NM_015669	NP_056484	Q9Y5E4	PCDB5_HUMAN	protocadherin beta 5 precursor	756	Cytoplasmic (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding|protein binding			skin(3)|ovary(2)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TGTTTGACCGGAGACTCAGGG	0.607			NA											48	76					0	0	0.00361	0	0
PCDHB16	57717	broad.mit.edu	37	5	140563898	140563898	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr5:140563898G>T	uc003liv.2	+	1	2919	c.1764G>T	c.(1762-1764)AAG>AAT	p.K588N	PCDHB9_uc003liw.1_5'Flank	NM_020957	NP_066008	Q9NRJ7	PCDBG_HUMAN	protocadherin beta 16 precursor	588	Cadherin 6.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			ovary(1)|pancreas(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TGGTGACCAAGGTGGTGGCGG	0.692			NA											14	15					3.32936e-07	4.1603e-07	0.006122	1	0
PCDHGA11	56105	broad.mit.edu	37	5	140802988	140802988	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr5:140802988G>C	uc003lkq.1	+	1	2452	c.2194G>C	c.(2194-2196)GGG>CGG	p.G732R	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc003lkh.1_Intron|PCDHGB6_uc003lkj.1_Intron|PCDHGA10_uc003lkl.1_Intron|PCDHGB7_uc003lkn.1_Intron|PCDHGA11_uc003lko.1_Missense_Mutation_p.G732R|PCDHGA11_uc003lkp.1_Intron|PCDHGB8P_uc011daz.1_5'Flank	NM_018914	NP_061737	Q9Y5H2	PCDGB_HUMAN	protocadherin gamma subfamily A, 11 isoform 1	732	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TTCTGAAGGCGGGTTGGCAGG	0.587			NA											8	21					0	0	0.004482	0	0
AFAP1L1	134265	broad.mit.edu	37	5	148712335	148712335	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr5:148712335G>C	uc003lqh.2	+	17	2184	c.2053G>C	c.(2053-2055)GAC>CAC	p.D685H	AFAP1L1_uc010jgy.2_Missense_Mutation_p.D685H|AFAP1L1_uc003lqi.1_Missense_Mutation_p.D300H	NM_152406	NP_689619	Q8TED9	AF1L1_HUMAN	actin filament associated protein 1-like 1	685	Potential.						protein binding			breast(1)|pancreas(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCGCCGGATTGACCTGGAGCT	0.592			NA											5	21					0	0	0.001168	0	0
TCOF1	6949	broad.mit.edu	37	5	149754931	149754931	+	Silent	SNP	G	G	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr5:149754931G>A	uc003lry.2	+	11	1626	c.1518G>A	c.(1516-1518)GTG>GTA	p.V506V	TCOF1_uc003lrw.2_Silent_p.V506V|TCOF1_uc011dch.1_Silent_p.V506V|TCOF1_uc003lrz.2_Silent_p.V506V|TCOF1_uc003lrx.2_Silent_p.V429V|TCOF1_uc003lsa.2_Silent_p.V429V|TCOF1_uc011dci.1_5'UTR	NM_001135243	NP_001128715	Q13428	TCOF_HUMAN	Treacher Collins-Franceschetti syndrome 1	506					skeletal system development	nucleolus	protein binding|transporter activity			ovary(2)|large_intestine(1)	3		all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			GCCCCCAGGTGAAACCTGCCT	0.627			NA											26	31					0	0	0.007291	0	0
SLC36A3	285641	broad.mit.edu	37	5	150682911	150682911	+	Nonsense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr5:150682911G>T	uc003ltw.2	-	1	424	c.5C>A	c.(4-6)TCA>TAA	p.S2*	GM2A_uc011dcs.1_Intron|SLC36A3_uc003ltx.2_Nonsense_Mutation_p.S2*	NM_181774	NP_861439	Q495N2	S36A3_HUMAN	solute carrier family 36, member 3 isoform 2	2	Cytoplasmic (Potential).					integral to membrane				ovary(2)|skin(1)	3		Medulloblastoma(196;0.109)|all_hematologic(541;0.243)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			TCCAAGCAATGACATCTTCAA	0.517			NA											32	33					2.2871e-25	3.98233e-25	0.007835	1	0
ADAM19	8728	broad.mit.edu	37	5	156946857	156946857	+	Missense_Mutation	SNP	C	C	A	rs147812090		TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr5:156946857C>A	uc003lwz.2	-	6	654	c.590G>T	c.(589-591)CGA>CTA	p.R197L	ADAM19_uc003lww.1_5'UTR|ADAM19_uc011ddr.1_Missense_Mutation_p.R128L	NM_033274	NP_150377	Q9H013	ADA19_HUMAN	ADAM metallopeptidase domain 19 preproprotein	197					proteolysis	integral to membrane	metalloendopeptidase activity|SH3 domain binding|zinc ion binding			ovary(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)|skin(1)	8	Renal(175;0.00488)	Medulloblastoma(196;0.0359)|all_neural(177;0.14)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			CCTGCGAGGTCGCTTCTTGGT	0.537			NA											26	30					4.74835e-14	7.16833e-14	0.002096	1	0
ODZ2	57451	broad.mit.edu	37	5	167379615	167379615	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr5:167379615G>T	uc010jjd.2	+	4	735	c.735G>T	c.(733-735)CAG>CAT	p.Q245H	ODZ2_uc003lzq.2_Missense_Mutation_p.Q124H|ODZ2_uc003lzr.3_Missense_Mutation_p.Q54H	NM_001122679	NP_001116151			odz, odd Oz/ten-m homolog 2											ovary(6)|central_nervous_system(4)	10	Renal(175;0.00124)|Lung NSC(126;0.136)|all_lung(126;0.242)	Medulloblastoma(196;0.0241)|all_neural(177;0.026)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0444)|OV - Ovarian serous cystadenocarcinoma(192;0.0694)|Epithelial(171;0.124)		ACCACAGCCAGTCGACTCTGA	0.562			NA											8	2					5.18039e-06	6.18734e-06	0.00308	1	0
PANK3	79646	broad.mit.edu	37	5	167991059	167991059	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr5:167991059C>A	uc003lzz.1	-	4	947	c.647G>T	c.(646-648)GGT>GTT	p.G216V		NM_024594	NP_078870	Q9H999	PANK3_HUMAN	pantothenate kinase 3	216					coenzyme A biosynthetic process	cytoplasm|nucleus	ATP binding|pantothenate kinase activity			ovary(1)	1	Renal(175;0.000159)|Lung NSC(126;0.0441)|all_lung(126;0.0909)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0989)|OV - Ovarian serous cystadenocarcinoma(192;0.147)|Epithelial(171;0.188)		CAGAAAGGTACCCCCTCCAAG	0.378			NA											33	31					6.50621e-10	8.96639e-10	0.002836	1	0
SNCB	6620	broad.mit.edu	37	5	176056603	176056603	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr5:176056603G>T	uc003mep.2	-	3	496	c.53C>A	c.(52-54)GCC>GAC	p.A18D	SNCB_uc003meq.2_Missense_Mutation_p.A18D|SNCB_uc010jke.1_Missense_Mutation_p.A18D|hsa-mir-4281|MI0015885_5'Flank|EIF4E1B_uc010jkf.1_5'Flank	NM_001001502	NP_001001502	Q16143	SYUB_HUMAN	beta-synuclein	18							calcium ion binding|phospholipase inhibitor activity			ovary(1)	1	all_cancers(89;0.00222)|Renal(175;0.000269)|Lung NSC(126;0.00902)|all_lung(126;0.0142)	Medulloblastoma(196;0.00498)|all_neural(177;0.0212)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			TTTCTCCGCGGCTGCCACAAC	0.677			NA											6	11					5.18039e-06	6.18734e-06	0.00308	1	0
ZNF454	285676	broad.mit.edu	37	5	178392082	178392082	+	Missense_Mutation	SNP	A	A	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr5:178392082A>T	uc003mjo.1	+	5	948	c.677A>T	c.(676-678)CAC>CTC	p.H226L	ZNF454_uc010jkz.1_Missense_Mutation_p.H226L	NM_182594	NP_872400	Q8N9F8	ZN454_HUMAN	zinc finger protein 454	226	C2H2-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|lung(1)	3	all_cancers(89;0.000904)|Renal(175;0.000159)|all_epithelial(37;0.000167)|Lung NSC(126;0.00199)|all_lung(126;0.00351)	all_cancers(40;0.225)|all_neural(177;0.00802)|Medulloblastoma(196;0.0145)|all_hematologic(541;0.248)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.234)		AAAGCCTTTCACCAGAGTACG	0.373			NA											22	43					0	0	0.004656	0	0
IRF4	3662	broad.mit.edu	37	6	397159	397159	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr6:397159G>T	uc003msz.3	+	5	657	c.544G>T	c.(544-546)GTC>TTC	p.V182F	IRF4_uc010jne.1_Missense_Mutation_p.V182F|IRF4_uc003mta.3_RNA|IRF4_uc003mtb.3_Missense_Mutation_p.V181F|IRF4_uc003mtc.1_Missense_Mutation_p.V12F	NM_002460	NP_002451	Q15306	IRF4_HUMAN	interferon regulatory factor 4	182					interferon-gamma-mediated signaling pathway|positive regulation of interleukin-10 biosynthetic process|positive regulation of interleukin-13 biosynthetic process|positive regulation of interleukin-2 biosynthetic process|positive regulation of interleukin-4 biosynthetic process|positive regulation of transcription, DNA-dependent|regulation of T-helper cell differentiation|T cell activation|type I interferon-mediated signaling pathway	cytoplasm	DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding			ovary(1)	1		Breast(5;0.0155)|all_lung(73;0.0691)|all_hematologic(90;0.0895)		OV - Ovarian serous cystadenocarcinoma(45;0.03)|BRCA - Breast invasive adenocarcinoma(62;0.0702)		GAGGGACTACGTCCCGGATCA	0.567			NA	T	IGH@	MM 								20	111					7.92952e-12	1.14812e-11	0.003954	1	0
IRF4	3662	broad.mit.edu	37	6	398857	398857	+	Missense_Mutation	SNP	T	T	C			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr6:398857T>C	uc003msz.3	+	6	780	c.667T>C	c.(667-669)TGT>CGT	p.C223R	IRF4_uc010jne.1_Missense_Mutation_p.C223R|IRF4_uc003mta.3_RNA|IRF4_uc003mtb.3_Missense_Mutation_p.C222R|IRF4_uc003mtc.1_Missense_Mutation_p.C53R	NM_002460	NP_002451	Q15306	IRF4_HUMAN	interferon regulatory factor 4	223					interferon-gamma-mediated signaling pathway|positive regulation of interleukin-10 biosynthetic process|positive regulation of interleukin-13 biosynthetic process|positive regulation of interleukin-2 biosynthetic process|positive regulation of interleukin-4 biosynthetic process|positive regulation of transcription, DNA-dependent|regulation of T-helper cell differentiation|T cell activation|type I interferon-mediated signaling pathway	cytoplasm	DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding			ovary(1)	1		Breast(5;0.0155)|all_lung(73;0.0691)|all_hematologic(90;0.0895)		OV - Ovarian serous cystadenocarcinoma(45;0.03)|BRCA - Breast invasive adenocarcinoma(62;0.0702)		CTTTTATGCTTGTGCCCCACC	0.567			NA	T	IGH@	MM 								7	20					0	0	0.006214	0	0
F13A1	2162	broad.mit.edu	37	6	6266977	6266977	+	Nonsense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr6:6266977C>A	uc003mwv.2	-	4	508	c.385G>T	c.(385-387)GGA>TGA	p.G129*	F13A1_uc011dib.1_Nonsense_Mutation_p.G66*	NM_000129	NP_000120	P00488	F13A_HUMAN	coagulation factor XIII A1 subunit precursor	129					peptide cross-linking|platelet activation|platelet degranulation	extracellular region|platelet alpha granule lumen	acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|pancreas(1)|skin(1)	6	Ovarian(93;0.0816)	all_hematologic(90;0.152)			L-Glutamine(DB00130)	CCCCACTTTCCACTTTGTAAC	0.488			NA											12	58					1.49906e-05	1.74694e-05	0.00245	1	0
DSP	1832	broad.mit.edu	37	6	7570791	7570791	+	Missense_Mutation	SNP	G	G	T	rs148147581	byFrequency	TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr6:7570791G>T	uc003mxp.1	+	13	1975	c.1696G>T	c.(1696-1698)GCC>TCC	p.A566S	DSP_uc003mxq.1_Missense_Mutation_p.A566S	NM_004415	NP_004406	P15924	DESP_HUMAN	desmoplakin isoform I	566	Globular 1.|Interacts with plakophilin 1 and junction plakoglobin.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			central_nervous_system(6)|ovary(2)|skin(1)	9	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		CATGACAATCGCCAAGGTATG	0.557			NA											18	57					7.41877e-09	9.84096e-09	0.001882	1	0
TFAP2A	7020	broad.mit.edu	37	6	10398806	10398806	+	Silent	SNP	G	G	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr6:10398806G>A	uc003myr.2	-	7	1410	c.1158C>T	c.(1156-1158)TTC>TTT	p.F386F	TFAP2A_uc003myq.2_Silent_p.F380F|TFAP2A_uc003mys.2_RNA|TFAP2A_uc011dih.1_3'UTR|TFAP2A_uc003myt.2_Silent_p.F382F	NM_003220	NP_003211	P05549	AP2A_HUMAN	transcription factor AP-2 alpha isoform a	386	H-S-H (helix-span-helix), dimerization.				ectoderm development|positive regulation of bone mineralization|positive regulation of tooth mineralization|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter	centrosome|Golgi apparatus|nucleus	chromatin binding|protein dimerization activity|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription regulatory region DNA binding			ovary(1)	1	Breast(50;0.0427)|Ovarian(93;0.0991)	all_hematologic(90;0.107)				CGGGGCTGCCGAAGCCGTGGG	0.627			NA											59	132					0	0	0.00361	0	0
ELOVL2	54898	broad.mit.edu	37	6	10984073	10984073	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr6:10984073C>T	uc003mzp.3	-	8	993	c.832G>A	c.(832-834)GGT>AGT	p.G278S		NM_017770	NP_060240	Q9NXB9	ELOV2_HUMAN	elongation of very long chain fatty acids-like	278					fatty acid elongation, polyunsaturated fatty acid|long-chain fatty-acyl-CoA biosynthetic process|triglyceride biosynthetic process|very long-chain fatty acid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	fatty acid elongase activity|protein binding				0	Breast(50;0.0418)|Ovarian(93;0.0919)	all_hematologic(90;0.117)	Epithelial(50;0.176)			TTGGAAAAACCATTCTTCACT	0.363			NA											8	38					0	0	0.006214	0	0
GPLD1	2822	broad.mit.edu	37	6	24445964	24445964	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr6:24445964G>C	uc003ned.1	-	19	2027	c.1916C>G	c.(1915-1917)TCT>TGT	p.S639C		NM_001503	NP_001494	P80108	PHLD_HUMAN	glycosylphosphatidylinositol specific	639	FG-GAP 5.					extracellular region	glycosylphosphatidylinositol phospholipase D activity			ovary(2)|kidney(1)	3						CTTGTCTCCAGAAATGGTAAA	0.473			NA											40	69					0	0	0.00361	0	0
ACOT13	55856	broad.mit.edu	37	6	24698141	24698141	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr6:24698141G>A	uc003nek.2	+	2	341	c.112G>A	c.(112-114)GTG>ATG	p.V38M	ACOT13_uc010jpv.2_Missense_Mutation_p.V15M	NM_018473	NP_060943	Q9NPJ3	ACO13_HUMAN	acyl-CoA thioesterase 13 isoform 1	38					protein homotetramerization	mitochondrion	acyl-CoA thioesterase activity				0						TCCTGGGAAAGTGATTTGTGA	0.388			NA											5	31					0	0	0.001168	0	0
HIST1H1E	3008	broad.mit.edu	37	6	26156882	26156882	+	Silent	SNP	G	G	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr6:26156882G>A	uc003ngq.2	+	1	324	c.264G>A	c.(262-264)GTG>GTA	p.V88V	HIST1H2BD_uc003ngr.2_5'Flank|HIST1H2BD_uc003ngs.2_5'Flank	NM_005321	NP_005312	P10412	H14_HUMAN	histone cluster 1, H1e	88	H15.				nucleosome assembly	nucleosome|nucleus	DNA binding|protein binding			large_intestine(1)|ovary(1)	2						AGAGCCTGGTGAGCAAGGGCA	0.597			NA											3	41					0	0	0.004672	0	0
HIST1H1E	3008	broad.mit.edu	37	6	26157278	26157278	+	Silent	SNP	G	G	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr6:26157278G>A	uc003ngq.2	+	1	720	c.660G>A	c.(658-660)TAG>TAA	p.*220*	HIST1H2BD_uc003ngr.2_5'Flank|HIST1H2BD_uc003ngs.2_5'Flank	NM_005321	NP_005312	P10412	H14_HUMAN	histone cluster 1, H1e	220					nucleosome assembly	nucleosome|nucleus	DNA binding|protein binding			large_intestine(1)|ovary(1)	2						AGAAAAAGTAGAAAGTTCCTT	0.527			NA											6	20					0	0	0.001984	0	0
HIST1H2BH	8345	broad.mit.edu	37	6	26252107	26252107	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr6:26252107G>A	uc003nhh.2	+	1	229	c.229G>A	c.(229-231)GAG>AAG	p.E77K	HIST1H3F_uc003nhg.1_5'Flank	NM_003524	NP_003515	Q93079	H2B1H_HUMAN	histone cluster 1, H2bh	77					nucleosome assembly	nucleosome|nucleus	DNA binding			ovary(3)	3						CATCGCCGGCGAGGCTTCCCG	0.592			NA											36	83					0	0	0.004878	0	0
SCAND3	114821	broad.mit.edu	37	6	28541251	28541251	+	Missense_Mutation	SNP	T	T	A	rs141088775	by1000genomes	TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr6:28541251T>A	uc003nlo.2	-	4	3033	c.2415A>T	c.(2413-2415)CAA>CAT	p.Q805H		NM_052923	NP_443155	Q6R2W3	SCND3_HUMAN	SCAN domain containing 3	805					DNA integration|viral reproduction	nucleus	DNA binding|protein dimerization activity|sequence-specific DNA binding transcription factor activity			ovary(1)	1						cctgctttggttggcttttca	0			NA											12	37					0	0	0.00245	0	0
OR2H1	26716	broad.mit.edu	37	6	29430378	29430378	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr6:29430378G>T	uc003nmi.2	+	3	1275	c.832G>T	c.(832-834)GTG>TTG	p.V278L	OR2H1_uc003nmj.1_Missense_Mutation_p.V278L|OR2H1_uc010jri.1_Missense_Mutation_p.V200L	NM_030883	NP_112145	Q9GZK4	OR2H1_HUMAN	olfactory receptor, family 2, subfamily H,	278	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						CTTCTATGCAGTGGGCACTCC	0.512			NA											13	32					2.31682e-05	2.68102e-05	0.003163	1	0
MOG	4340	broad.mit.edu	37	6	29627401	29627401	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr6:29627401C>A	uc003nnf.2	+	2	572	c.394C>A	c.(394-396)CAT>AAT	p.H132N	MOG_uc003qzk.1_Missense_Mutation_p.H132N|MOG_uc010kle.1_Intron|MOG_uc010klf.1_Intron|MOG_uc003nmy.1_Missense_Mutation_p.H132N|MOG_uc003nmz.2_Missense_Mutation_p.H132N|MOG_uc011dlt.1_Missense_Mutation_p.H62N|MOG_uc003nna.2_Intron|MOG_uc011dlu.1_Intron|MOG_uc011dlv.1_Intron|MOG_uc003nnd.2_Missense_Mutation_p.H132N|MOG_uc003nne.2_Missense_Mutation_p.H132N|MOG_uc003nng.2_Missense_Mutation_p.H132N|MOG_uc003nnh.2_Missense_Mutation_p.H132N|MOG_uc003nni.2_Missense_Mutation_p.H132N|MOG_uc003nnj.2_Missense_Mutation_p.H132N|MOG_uc003nnk.2_Missense_Mutation_p.H132N	NM_206809	NP_996532	Q16653	MOG_HUMAN	myelin oligodendrocyte glycoprotein isoform	132	Ig-like V-type.|Extracellular (Potential).				cell adhesion|central nervous system development|positive regulation of MyD88-dependent toll-like receptor signaling pathway	integral to membrane|plasma membrane				ovary(1)	1						CTTCCGAGATCATTCTTACCA	0.433			NA											7	28					2.0095e-06	2.44928e-06	0.001984	1	0
GNL1	2794	broad.mit.edu	37	6	30521208	30521208	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr6:30521208G>A	uc003nqh.2	-	6	1755	c.727C>T	c.(727-729)CAT>TAT	p.H243Y	GNL1_uc011dmi.1_Missense_Mutation_p.H105Y|GNL1_uc011dmj.1_Missense_Mutation_p.H241Y|GNL1_uc011dmk.1_Intron	NM_005275	NP_005266	P36915	GNL1_HUMAN	guanine nucleotide binding protein-like 1	243					response to DNA damage stimulus|signal transduction|T cell mediated immunity	extracellular space|intracellular	GTP binding|structural molecule activity			ovary(3)	3						TAGTGTTGATGGAAATAATGC	0.552			NA											33	77					0	0	0.004878	0	0
MSH5	4439	broad.mit.edu	37	6	31725979	31725979	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr6:31725979G>T	uc003nwv.1	+	13	1131	c.1052G>T	c.(1051-1053)CGC>CTC	p.R351L	MSH5_uc003nwt.1_Missense_Mutation_p.R368L|MSH5_uc003nwu.1_Missense_Mutation_p.R351L|MSH5_uc003nww.1_Missense_Mutation_p.R351L|MSH5_uc003nwx.1_Missense_Mutation_p.R368L|MSH5_uc011dof.1_Missense_Mutation_p.R50L|MSH5_uc003nwy.1_Missense_Mutation_p.R25L|MSH5_uc003nwz.3_5'Flank	NM_172166	NP_751898	O43196	MSH5_HUMAN	mutS homolog 5 isoform c	351					chiasma assembly|homologous chromosome segregation|meiotic prophase II|mismatch repair|reciprocal meiotic recombination	synaptonemal complex	ATP binding|DNA-dependent ATPase activity|mismatched DNA binding			ovary(2)|breast(1)	3						GATGCCTGCCGCTCCCTGCCG	0.562			NA						Direct_reversal_of_damage|MMR					6	51					8.12818e-05	9.21236e-05	0.001984	1	0
NOTCH4	4855	broad.mit.edu	37	6	32178620	32178620	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr6:32178620C>A	uc003obb.2	-	18	2913	c.2774G>T	c.(2773-2775)AGC>ATC	p.S925I	NOTCH4_uc011dpu.1_RNA|NOTCH4_uc011dpv.1_RNA	NM_004557	NP_004548	Q99466	NOTC4_HUMAN	notch4 preproprotein	925	EGF-like 23.|Extracellular (Potential).				cell fate determination|embryo development|hemopoiesis|mammary gland development|negative regulation of endothelial cell differentiation|Notch receptor processing|Notch signaling pathway|patterning of blood vessels|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|protein heterodimerization activity|receptor activity			lung(8)|ovary(5)|breast(4)|central_nervous_system(3)|upper_aerodigestive_tract(1)|skin(1)	22						CTGGCACAGGCTGCCTTGGAA	0.622			NA											19	28					2.4624e-09	3.32569e-09	0.008871	1	0
NOTCH4	4855	broad.mit.edu	37	6	32190416	32190416	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr6:32190416C>A	uc003obb.2	-	3	462	c.323G>T	c.(322-324)GGC>GTC	p.G108V	NOTCH4_uc011dpu.1_RNA|NOTCH4_uc011dpv.1_RNA|NOTCH4_uc003obc.2_Missense_Mutation_p.G108V	NM_004557	NP_004548	Q99466	NOTC4_HUMAN	notch4 preproprotein	108	Extracellular (Potential).|EGF-like 2.				cell fate determination|embryo development|hemopoiesis|mammary gland development|negative regulation of endothelial cell differentiation|Notch receptor processing|Notch signaling pathway|patterning of blood vessels|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|protein heterodimerization activity|receptor activity			lung(8)|ovary(5)|breast(4)|central_nervous_system(3)|upper_aerodigestive_tract(1)|skin(1)	22						ACCAGTGAAGCCAGGGAGGCA	0.622			NA											12	40					0.000132079	0.000149241	0.008871	1	0
BTNL2	56244	broad.mit.edu	37	6	32362549	32362549	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr6:32362549C>A	uc003obg.1	-	6	1332	c.1332G>T	c.(1330-1332)GAG>GAT	p.E444D	BTNL2_uc010jty.1_Missense_Mutation_p.E167D|BTNL2_uc010jtz.1_RNA|BTNL2_uc010jua.1_Missense_Mutation_p.E234D	NM_019602	NP_062548	Q9UIR0	BTNL2_HUMAN	butyrophilin-like 2	444	Extracellular (Potential).					integral to membrane				central_nervous_system(1)	1						CGATTTTCTCCTCGCCCAAAA	0.458			NA											7	38					1.76689e-08	2.32305e-08	0.006214	1	0
TULP1	7287	broad.mit.edu	37	6	35477640	35477640	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr6:35477640C>G	uc003okv.3	-	6	577	c.565G>C	c.(565-567)GGG>CGG	p.G189R	TULP1_uc003okw.3_Missense_Mutation_p.G136R	NM_003322	NP_003313	O00294	TULP1_HUMAN	tubby like protein 1	189					dendrite development|eye photoreceptor cell development|phagocytosis|photoreceptor cell maintenance|positive regulation of phagocytosis	cell junction|cytoplasm|extracellular region|photoreceptor inner segment|photoreceptor outer segment|synapse	actin filament binding|phosphatidylinositol-4,5-bisphosphate binding			ovary(2)|central_nervous_system(1)	3						GTCCCCTCCCCTGCTGGAGCT	0.567	GBM(55;1027 1091 11115 23439)		NA											39	74					0	0	0.002852	0	0
MTCH1	23787	broad.mit.edu	37	6	36938181	36938181	+	Splice_Site	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr6:36938181C>A	uc003ond.1	-	10	1022	c.1022_splice	c.e10+1	p.G341_splice	MTCH1_uc003onc.1_Splice_Site_p.G324_splice|MTCH1_uc010jwo.1_Splice_Site|MTCH1_uc003one.3_Splice_Site_p.G341_splice|MTCH1_uc011dtt.1_Splice_Site_p.G156_splice	NM_014341	NP_055156	Q9NZJ7	MTCH1_HUMAN	mitochondrial carrier homolog 1						activation of caspase activity|neuronal ion channel clustering|positive regulation of apoptosis|regulation of signal transduction|transport	integral to membrane|mitochondrial inner membrane	protein binding				0						CGCACACCTACCCGCAGTTGT	0.612			NA											35	83					9.39024e-22	1.59035e-21	0.009718	1	0
DNAH8	1769	broad.mit.edu	37	6	38813461	38813461	+	Nonsense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr6:38813461G>T	uc003ooe.1	+	34	4906	c.4306G>T	c.(4306-4308)GAG>TAG	p.E1436*		NM_001371	NP_001362			dynein, axonemal, heavy polypeptide 8											skin(8)|ovary(7)|lung(2)|large_intestine(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	21						GGGAAAAGGAGAGCTCCTGCT	0.408			NA											21	46					2.39556e-15	3.71838e-15	0.00278	1	0
DNAH8	1769	broad.mit.edu	37	6	38942254	38942254	+	Silent	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr6:38942254C>A	uc003ooe.1	+	83	12732	c.12132C>A	c.(12130-12132)CCC>CCA	p.P4044P	DNAH8_uc003oog.1_Silent_p.P493P	NM_001371	NP_001362			dynein, axonemal, heavy polypeptide 8											skin(8)|ovary(7)|lung(2)|large_intestine(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	21						GTAATTTACCCATGTGGAAGC	0.443			NA											21	42					4.72057e-08	6.12521e-08	0.003954	1	0
KCNK5	8645	broad.mit.edu	37	6	39162477	39162477	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr6:39162477G>C	uc003oon.2	-	3	722	c.358C>G	c.(358-360)CTC>GTC	p.L120V		NM_003740	NP_003731	O95279	KCNK5_HUMAN	potassium channel, subfamily K, member 5	120	Helical; (Potential).				excretion	integral to plasma membrane	potassium channel activity|voltage-gated ion channel activity			central_nervous_system(1)|skin(1)	2						ACCCCGAAGAGACCATAGAAA	0.587			NA											31	85					0	0	0.007835	0	0
KCNK16	83795	broad.mit.edu	37	6	39285716	39285716	+	Missense_Mutation	SNP	A	A	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr6:39285716A>T	uc003ooq.2	-	3	355	c.341T>A	c.(340-342)CTG>CAG	p.L114Q	KCNK16_uc003oor.3_Missense_Mutation_p.L114Q|KCNK16_uc010jwy.2_Missense_Mutation_p.L114Q|KCNK16_uc011dtz.1_Missense_Mutation_p.L114Q	NM_032115	NP_115491	Q96T55	KCNKG_HUMAN	potassium channel, subfamily K, member 16	114						integral to membrane	potassium channel activity|voltage-gated ion channel activity			ovary(2)|skin(1)	3						GCTGGGTGCCAGGTTCCCATA	0.567			NA											14	19					0	0	0.007413	0	0
KIF6	221458	broad.mit.edu	37	6	39682526	39682526	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr6:39682526C>A	uc003oot.2	-	3	288	c.193G>T	c.(193-195)GAT>TAT	p.D65Y	KIF6_uc011dua.1_Missense_Mutation_p.D65Y|KIF6_uc010jxb.1_Missense_Mutation_p.D65Y|KIF6_uc003oou.2_RNA	NM_145027	NP_659464	Q6ZMV9	KIF6_HUMAN	kinesin family member 6	65	Kinesin-motor.				microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity|protein binding			breast(2)|central_nervous_system(1)	3						GCATCCTGATCAAAAATTCTT	0.358			NA											7	27					3.09899e-07	3.88222e-07	0.004482	1	0
UNC5CL	222643	broad.mit.edu	37	6	41001699	41001699	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr6:41001699C>T	uc003opi.2	-	3	696	c.607G>A	c.(607-609)GCC>ACC	p.A203T	UNC5CL_uc010jxe.1_Missense_Mutation_p.A203T	NM_173561	NP_775832	Q8IV45	UN5CL_HUMAN	unc-5 homolog C-like	203	ZU5.|Cytoplasmic (Potential).|Interaction with RELA and NFKB1.				signal transduction	cytoplasm|integral to membrane				ovary(2)	2	Ovarian(28;0.0418)|Colorectal(47;0.196)					CATACCTTGGCATCCAGCAGG	0.637			NA											9	19					0	0	0.004482	0	0
NFYA	4800	broad.mit.edu	37	6	41060812	41060812	+	Silent	SNP	A	A	G			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr6:41060812A>G	uc003opo.2	+	8	1054	c.876A>G	c.(874-876)CCA>CCG	p.P292P	NFYA_uc003opp.2_Silent_p.P263P|NFYA_uc003opq.2_Silent_p.P263P	NM_002505	NP_002496	P23511	NFYA_HUMAN	nuclear transcription factor Y, alpha isoform 1	292					transcription from RNA polymerase II promoter	CCAAT-binding factor complex	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity				0	Ovarian(28;0.0418)|Colorectal(47;0.196)					GGAAAATTCCAAAGGAGAGAA	0.413			NA											5	26					0	0	0.001984	0	0
PGC	5225	broad.mit.edu	37	6	41704680	41704680	+	Silent	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr6:41704680G>T	uc003ora.1	-	9	1126	c.1077C>A	c.(1075-1077)CCC>CCA	p.P359P	TFEB_uc003oqs.1_5'Flank|TFEB_uc003oqt.1_5'Flank|TFEB_uc003oqu.1_5'Flank|TFEB_uc010jxq.1_5'Flank	NM_002630	NP_002621	P20142	PEPC_HUMAN	progastricsin (pepsinogen C) precursor	359					digestion|proteolysis	extracellular space	aspartic-type endopeptidase activity				0	Ovarian(28;0.0355)|Colorectal(47;0.121)		Epithelial(12;0.000132)|STAD - Stomach adenocarcinoma(11;0.000204)|Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00507)			GGATCCACAGGGGCTGGCCGT	0.537			NA											16	18					2.5808e-16	4.09567e-16	0.006122	1	0
PGC	5225	broad.mit.edu	37	6	41710072	41710072	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr6:41710072C>G	uc003ora.1	-	5	652	c.603G>C	c.(601-603)CAG>CAC	p.Q201H		NM_002630	NP_002621	P20142	PEPC_HUMAN	progastricsin (pepsinogen C) precursor	201					digestion|proteolysis	extracellular space	aspartic-type endopeptidase activity				0	Ovarian(28;0.0355)|Colorectal(47;0.121)		Epithelial(12;0.000132)|STAD - Stomach adenocarcinoma(11;0.000204)|Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00507)			GGGCGCCCTCCTGCACCATGC	0.647			NA											24	71					0	0	0.005443	0	0
TRERF1	55809	broad.mit.edu	37	6	42225893	42225893	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr6:42225893C>G	uc003osd.2	-	10	2879	c.2316G>C	c.(2314-2316)GAG>GAC	p.E772D	TRERF1_uc011duq.1_Missense_Mutation_p.E689D|TRERF1_uc003osb.2_Missense_Mutation_p.E528D|TRERF1_uc003osc.2_Missense_Mutation_p.E528D|TRERF1_uc003ose.2_Missense_Mutation_p.E792D	NM_033502	NP_277037	Q96PN7	TREF1_HUMAN	transcriptional regulating factor 1	772	Interacts with CREBBP.				cholesterol catabolic process|homeostatic process|multicellular organismal development|positive regulation of transcription, DNA-dependent|regulation of hormone biosynthetic process|steroid biosynthetic process	nucleus	DNA bending activity|ligand-dependent nuclear receptor transcription coactivator activity|RNA polymerase II transcription cofactor activity|sequence-specific DNA binding transcription factor activity|transcription factor binding|zinc ion binding			ovary(3)|pancreas(1)|skin(1)	5	Colorectal(47;0.196)		Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)			CTACAGTCTGCTCTCCAGGCC	0.433			NA											8	38					0	0	0.000978	0	0
UBR2	23304	broad.mit.edu	37	6	42541585	42541586	+	Missense_Mutation	DNP	GG	GG	TT			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr6:42541585_42541586GG>TT	uc011dur.1	+	2	192_193	c.192_193GG>TT	c.(190-195)CTGGCA>CTTTCA	p.A65S	UBR2_uc003osf.2_Missense_Mutation_p.A65S	NM_015255	NP_056070	Q8IWV8	UBR2_HUMAN	ubiquitin protein ligase E3 component n-recognin	65					cellular response to leucine|chromatin silencing|histone H2A ubiquitination|negative regulation of TOR signaling cascade	nucleus|plasma membrane	leucine binding|zinc ion binding			ovary(3)|pancreas(1)	4	Colorectal(47;0.196)		Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)|all cancers(41;0.004)|KIRC - Kidney renal clear cell carcinoma(15;0.02)|Kidney(15;0.0388)|OV - Ovarian serous cystadenocarcinoma(102;0.196)			AAGACATGCTGGCACAGCATGT	0.45			NA											20	39					0	0	0.004672	0	0
HSP90AB1	3326	broad.mit.edu	37	6	44219848	44219848	+	Silent	SNP	C	C	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr6:44219848C>T	uc003oxa.1	+	10	1659	c.1575C>T	c.(1573-1575)CTC>CTT	p.L525L	HSP90AB1_uc011dvr.1_Silent_p.L515L|HSP90AB1_uc003oxb.1_Silent_p.L525L|HSP90AB1_uc011dvs.1_Silent_p.L345L|HSP90AB1_uc003oxc.1_Silent_p.L163L	NM_007355	NP_031381	P08238	HS90B_HUMAN	heat shock 90kDa protein 1, beta	525					axon guidance|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of nitric oxide biosynthetic process|protein folding|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|response to unfolded protein	cytosol|melanosome	ATP binding|nitric-oxide synthase regulator activity|TPR domain binding|unfolded protein binding			lung(3)|breast(1)	4	all_cancers(18;1.7e-05)|all_lung(25;0.00747)|Hepatocellular(11;0.00908)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)			TGCAGCAGCTCAAGGAATTTG	0.537			NA											4	25					0	0	0.009096	0	0
TCTE1	202500	broad.mit.edu	37	6	44249877	44249877	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr6:44249877G>T	uc003oxi.2	-	4	1422	c.1266C>A	c.(1264-1266)AGC>AGA	p.S422R	SPATS1_uc003oxg.2_Intron|TMEM151B_uc003oxf.2_Intron	NM_182539	NP_872345	Q5JU00	TCTE1_HUMAN	t-complex-associated testis expressed 1	422	LRR 5.									ovary(2)|skin(2)	4	Hepatocellular(11;0.00908)|all_lung(25;0.0101)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)			ACAGGTTGATGCTGGTGAGTG	0.582			NA											18	35					0.00887093	0.00932231	0.008871	1	0
SUPT3H	8464	broad.mit.edu	37	6	44988328	44988328	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr6:44988328C>A	uc003oxo.2	-	6	579	c.261G>T	c.(259-261)AGG>AGT	p.R87S	SUPT3H_uc003oxn.1_Missense_Mutation_p.R76S|SUPT3H_uc011dvv.1_5'UTR|SUPT3H_uc003oxp.2_Missense_Mutation_p.R76S|SUPT3H_uc011dvw.1_5'UTR	NM_181356	NP_852001	O75486	SUPT3_HUMAN	suppressor of Ty 3 homolog isoform 2	158					histone deubiquitination|histone H3 acetylation|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|transcription initiation, DNA-dependent	STAGA complex|transcription factor TFTC complex	DNA binding|transcription coactivator activity			ovary(2)|breast(1)	3						GAGTGATTACCCTTGCTCCCC	0.313			NA											18	47					1.66031e-10	2.31168e-10	0.003954	1	0
GPR110	266977	broad.mit.edu	37	6	46995498	46995498	+	Splice_Site	SNP	C	C	G			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr6:46995498C>G	uc003oyt.2	-	3	269	c.70_splice	c.e3-1	p.K24_splice	GPR110_uc011dwl.1_Intron|GPR110_uc003oyu.1_Splice_Site_p.K24_splice	NM_153840	NP_722582	Q5T601	GP110_HUMAN	G-protein coupled receptor 110 isoform 1						neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(2)|pancreas(1)	3						CATCATTTTTCTGTTAAAAAG	0.274			NA											7	28					0	0	0.00308	0	0
CRISP2	7180	broad.mit.edu	37	6	49660511	49660511	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr6:49660511C>A	uc003ozq.2	-	10	963	c.707G>T	c.(706-708)TGC>TTC	p.C236F	CRISP2_uc003ozl.2_Missense_Mutation_p.C236F|CRISP2_uc003ozn.2_Missense_Mutation_p.C236F|CRISP2_uc003ozr.2_Missense_Mutation_p.C236F|CRISP2_uc003ozo.2_Missense_Mutation_p.C236F|CRISP2_uc003ozm.2_Missense_Mutation_p.C271F|CRISP2_uc003ozp.2_Missense_Mutation_p.C236F	NM_001142408	NP_001135880	P16562	CRIS2_HUMAN	cysteine-rich secretory protein 2 precursor	236						extracellular space				skin(1)	1	Lung NSC(77;0.0161)		KIRC - Kidney renal clear cell carcinoma(2;0.106)|Kidney(12;0.156)			CTCACATAGGCAAGTAGCCTT	0.398			NA											12	56					0.00136819	0.0014818	0.001368	1	0
CRISP3	10321	broad.mit.edu	37	6	49701533	49701533	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr6:49701533C>T	uc003ozs.2	-	5	321	c.306G>A	c.(304-306)ATG>ATA	p.M102I		NM_006061	NP_006052	P54108	CRIS3_HUMAN	cysteine-rich secretory protein 3 precursor	102					innate immune response	proteinaceous extracellular matrix|specific granule				skin(2)	2	Lung NSC(77;0.0161)		KIRC - Kidney renal clear cell carcinoma(2;0.106)|Kidney(12;0.156)			AGGCACTTGACATGTAGAGAT	0.438			NA											23	60					0	0	0.005443	0	0
PGK2	5232	broad.mit.edu	37	6	49754589	49754589	+	Silent	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr6:49754589C>A	uc003ozu.2	-	1	419	c.312G>T	c.(310-312)GTG>GTT	p.V104V		NM_138733	NP_620061	P07205	PGK2_HUMAN	phosphoglycerate kinase 2	104					glycolysis	cytosol	ATP binding|phosphoglycerate kinase activity			ovary(1)	1	Lung NSC(77;0.0402)					AGGCTTTCTCCACTTCTGCGC	0.527			NA											20	53					1.28384e-07	1.62751e-07	0.001882	1	0
PGK2	5232	broad.mit.edu	37	6	49754737	49754737	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr6:49754737G>T	uc003ozu.2	-	1	271	c.164C>A	c.(163-165)GCC>GAC	p.A55D		NM_138733	NP_620061	P07205	PGK2_HUMAN	phosphoglycerate kinase 2	55					glycolysis	cytosol	ATP binding|phosphoglycerate kinase activity			ovary(1)	1	Lung NSC(77;0.0402)					TACTGCCTTGGCTCCATTGTC	0.463			NA											20	42					2.70639e-06	3.26922e-06	0.002299	1	0
CRISP1	167	broad.mit.edu	37	6	49815968	49815968	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr6:49815968C>A	uc003ozw.2	-	4	319	c.240G>T	c.(238-240)AAG>AAT	p.K80N	CRISP1_uc003ozx.2_Missense_Mutation_p.K80N	NM_001131	NP_001122	P54107	CRIS1_HUMAN	acidic epididymal glycoprotein-like 1 isoform 1	80					fusion of sperm to egg plasma membrane	extracellular space					0	Lung NSC(77;0.0358)					TATCACAATACTTTGAAAAAA	0.348			NA											21	70					4.87955e-14	7.35147e-14	0.005443	1	0
PKHD1	5314	broad.mit.edu	37	6	51875134	51875134	+	Silent	SNP	T	T	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr6:51875134T>A	uc003pah.1	-	35	6000	c.5724A>T	c.(5722-5724)ATA>ATT	p.I1908I	PKHD1_uc003pai.2_Silent_p.I1908I	NM_138694	NP_619639	P08F94	PKHD1_HUMAN	fibrocystin isoform 1	1908	Extracellular (Potential).				cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			lung(15)|ovary(15)|large_intestine(5)|central_nervous_system(3)|skin(3)|breast(2)|upper_aerodigestive_tract(1)	44	Lung NSC(77;0.0605)					AGCGTTTCCGTATCTCAGTAA	0.378			NA											12	28					0	0	0.001855	0	0
DST	667	broad.mit.edu	37	6	56510775	56510775	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr6:56510775C>A	uc003pdf.2	-	14	1596	c.1568G>T	c.(1567-1569)GGA>GTA	p.G523V	DST_uc003pcz.3_Missense_Mutation_p.G345V|DST_uc011dxj.1_Missense_Mutation_p.G374V|DST_uc011dxk.1_Missense_Mutation_p.G385V|DST_uc011dxl.1_Missense_Mutation_p.G374V|DST_uc003pde.2_Missense_Mutation_p.G461V	NM_001144769	NP_001138241	Q03001	DYST_HUMAN	dystonin isoform 2	345					cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			ovary(7)|central_nervous_system(6)|upper_aerodigestive_tract(1)	14	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			CTTGATGCGTCCAAATTCTAT	0.358			NA											3	8					0.004672	0.00493414	0.004672	1	0
EYS	346007	broad.mit.edu	37	6	66205301	66205301	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr6:66205301C>G	uc011dxu.1	-	4	541	c.3G>C	c.(1-3)ATG>ATC	p.M1I	EYS_uc003peq.2_Missense_Mutation_p.M1I|EYS_uc003per.1_Missense_Mutation_p.M1I|EYS_uc010kaj.1_Intron	NM_001142800	NP_001136272	Q5T1H1	EYS_HUMAN	eyes shut homolog isoform 1	1					response to stimulus|visual perception	extracellular region	calcium ion binding			lung(4)|ovary(1)|skin(1)	6						ATTTGTCAGTCATTTTCGGGT	0.264			NA											6	19					0	0	0.001984	0	0
BAI3	577	broad.mit.edu	37	6	69640461	69640461	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr6:69640461G>A	uc003pev.3	+	4	1216	c.768G>A	c.(766-768)ATG>ATA	p.M256I	BAI3_uc010kak.2_Missense_Mutation_p.M256I	NM_001704	NP_001695	O60242	BAI3_HUMAN	brain-specific angiogenesis inhibitor 3	256	Extracellular (Potential).				negative regulation of angiogenesis|neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			lung(27)|ovary(8)|skin(6)|pancreas(4)|central_nervous_system(3)|urinary_tract(1)|breast(1)	50		all_lung(197;0.212)				AATTTGGAATGATGGGAGATC	0.363			NA											9	16					0	0	0.004482	0	0
COL19A1	1310	broad.mit.edu	37	6	70851915	70851915	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr6:70851915G>T	uc003pfc.1	+	22	1636	c.1519G>T	c.(1519-1521)GGT>TGT	p.G507C	COL19A1_uc010kam.1_Missense_Mutation_p.G403C	NM_001858	NP_001849	Q14993	COJA1_HUMAN	alpha 1 type XIX collagen precursor	507	Triple-helical region 3 (COL3).				cell differentiation|cell-cell adhesion|extracellular matrix organization|skeletal system development	collagen	extracellular matrix structural constituent|protein binding, bridging			ovary(2)|breast(2)	4						ACGTGTTTAGGGTGAACCTGG	0.388			NA											10	17					5.16669e-11	7.3031e-11	0.000978	1	0
FAM135A	57579	broad.mit.edu	37	6	71246009	71246009	+	Missense_Mutation	SNP	A	A	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr6:71246009A>T	uc003pfj.2	+	17	4145	c.4012A>T	c.(4012-4014)ACA>TCA	p.T1338S	FAM135A_uc003pfi.2_Missense_Mutation_p.T1142S|FAM135A_uc003pfh.2_Missense_Mutation_p.T1125S|FAM135A_uc003pfl.2_Missense_Mutation_p.T1005S|FAM135A_uc003pfn.2_Missense_Mutation_p.T544S|FAM135A_uc003pfo.1_Missense_Mutation_p.T709S|FAM135A_uc010kan.1_Missense_Mutation_p.T117S	NM_001162529	NP_001156001	Q9P2D6	F135A_HUMAN	hypothetical protein LOC57579 isoform c	1338										central_nervous_system(1)	1						TTCAGTGCTTACAAGGCCAAG	0.343			NA											5	55					0	0	0.001168	0	0
SLC17A5	26503	broad.mit.edu	37	6	74331599	74331599	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr6:74331599G>T	uc003phn.3	-	7	1034	c.906C>A	c.(904-906)AAC>AAA	p.N302K	SLC17A5_uc010kax.2_Intron|SLC17A5_uc010kay.2_RNA|SLC17A5_uc011dyo.1_Missense_Mutation_p.N171K	NM_012434	NP_036566	Q9NRA2	S17A5_HUMAN	sialin	302					anion transport	integral to plasma membrane|lysosomal membrane|membrane fraction	sialic acid:hydrogen symporter activity			skin(5)|central_nervous_system(1)	6						AAAAAGTCCAGTTGTAAGAAA	0.373			NA											9	33					6.40141e-05	7.28859e-05	0.000978	1	0
ELOVL4	6785	broad.mit.edu	37	6	80634726	80634726	+	Silent	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr6:80634726C>A	uc003pja.3	-	3	631	c.312G>T	c.(310-312)GCG>GCT	p.A104A	ELOVL4_uc011dyt.1_Intron	NM_022726	NP_073563	Q9GZR5	ELOV4_HUMAN	elongation of very long chain fatty acids-like	104					fatty acid elongation, saturated fatty acid|long-chain fatty-acyl-CoA biosynthetic process|triglyceride biosynthetic process|very long-chain fatty acid biosynthetic process	integral to endoplasmic reticulum membrane	G-protein coupled photoreceptor activity|protein binding|transferase activity, transferring acyl groups other than amino-acyl groups			ovary(1)|skin(1)	2		all_cancers(76;1.83e-05)|Acute lymphoblastic leukemia(125;1.1e-05)|all_hematologic(105;0.00117)|all_epithelial(107;0.011)		BRCA - Breast invasive adenocarcinoma(397;0.0168)	Alpha-Linolenic Acid(DB00132)	AGCTATATCCCGCATTATATG	0.279			NA											21	37					7.92952e-12	1.14812e-11	0.003954	1	0
HTR1E	3354	broad.mit.edu	37	6	87725103	87725103	+	Silent	SNP	G	G	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr6:87725103G>A	uc003pli.2	+	2	754	c.51G>A	c.(49-51)AAG>AAA	p.K17K		NM_000865	NP_000856	P28566	5HT1E_HUMAN	5-hydroxytryptamine (serotonin) receptor 1E	17	Extracellular (By similarity).				G-protein signaling, coupled to cyclic nucleotide second messenger|synaptic transmission	integral to plasma membrane	protein binding|serotonin binding|serotonin receptor activity			ovary(2)|skin(1)	3		all_cancers(76;7.11e-06)|Acute lymphoblastic leukemia(125;1.2e-09)|Prostate(29;3.51e-09)|all_hematologic(105;7.43e-06)|all_epithelial(107;0.00819)		BRCA - Breast invasive adenocarcinoma(108;0.055)	Eletriptan(DB00216)	TAAGACCCAAGACCATCACTG	0.478			NA											12	35					0	0	0.001855	0	0
GPR63	81491	broad.mit.edu	37	6	97247545	97247545	+	Silent	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr6:97247545C>A	uc010kcl.2	-	3	541	c.63G>T	c.(61-63)GTG>GTT	p.V21V	GPR63_uc003pou.2_Silent_p.V21V	NM_001143957	NP_001137429	Q9BZJ6	GPR63_HUMAN	G protein-coupled receptor 63	21	Extracellular (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity|protein binding			upper_aerodigestive_tract(1)|ovary(1)	2		all_cancers(76;6.89e-05)|Acute lymphoblastic leukemia(125;7.02e-10)|all_hematologic(75;1.23e-06)|all_epithelial(107;0.0618)|Colorectal(196;0.0721)		BRCA - Breast invasive adenocarcinoma(108;0.0912)		TGTTTTCATACACGACAAATG	0.468			NA											11	81					7.03913e-09	9.3457e-09	0.001368	1	0
PRDM1	639	broad.mit.edu	37	6	106553510	106553510	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr6:106553510C>G	uc003prd.2	+	5	1709	c.1475C>G	c.(1474-1476)CCC>CGC	p.P492R	PRDM1_uc003pre.2_Missense_Mutation_p.P358R	NM_001198	NP_001189	O75626	PRDM1_HUMAN	PR domain containing 1, with ZNF domain isoform	492					negative regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(54)|ovary(1)|skin(1)	56	Breast(9;0.022)	all_cancers(87;2.2e-31)|all_epithelial(87;2.03e-21)|Acute lymphoblastic leukemia(125;4.99e-11)|all_lung(197;7.55e-09)|all_hematologic(75;5.82e-08)|Lung NSC(302;1.28e-06)|Colorectal(196;0.0112)|Ovarian(999;0.0365)		all cancers(137;1.83e-46)|Epithelial(106;5.59e-35)|OV - Ovarian serous cystadenocarcinoma(136;1.99e-20)|GBM - Glioblastoma multiforme(226;3.72e-11)|BRCA - Breast invasive adenocarcinoma(108;1.38e-05)		GTCCCGGCGCCCCACAGTGCC	0.682			NA	D|N|Mis|F|S		DLBCL								16	34					0	0	0.004007	0	0
WASF1	8936	broad.mit.edu	37	6	110422792	110422792	+	Missense_Mutation	SNP	T	T	G			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr6:110422792T>G	uc003ptv.1	-	10	2358	c.1521A>C	c.(1519-1521)AAA>AAC	p.K507N	WASF1_uc003ptw.1_Missense_Mutation_p.K507N|WASF1_uc003ptx.1_Missense_Mutation_p.K507N|WASF1_uc003pty.1_Missense_Mutation_p.K507N	NM_003931	NP_003922	Q92558	WASF1_HUMAN	Wiskott-Aldrich syndrome protein family member	507	WH2.				actin filament polymerization|cellular component movement	actin cytoskeleton	actin binding				0		all_cancers(87;1.18e-05)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;0.00159)|Colorectal(196;0.0488)		OV - Ovarian serous cystadenocarcinoma(136;0.0364)|Epithelial(106;0.051)|all cancers(137;0.0687)		GAAAATTACCTTTTCGTATTG	0.383			NA											12	73					0	0	0.003163	0	0
DDO	8528	broad.mit.edu	37	6	110734560	110734560	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr6:110734560C>A	uc003puc.2	-	2	194	c.190G>T	c.(190-192)GAC>TAC	p.D64Y	C6orf186_uc003pub.2_5'Flank|DDO_uc003pud.2_Missense_Mutation_p.D64Y	NM_003649	NP_003640	Q99489	OXDD_HUMAN	D-aspartate oxidase isoform a	36	FAD (By similarity).				aspartate catabolic process	peroxisome	binding|D-amino-acid oxidase activity|D-aspartate oxidase activity			ovary(2)|breast(1)	3		all_cancers(87;3.47e-21)|all_epithelial(87;9.03e-20)|Acute lymphoblastic leukemia(125;2.13e-07)|all_hematologic(75;5.28e-06)|all_lung(197;2.98e-05)|Lung NSC(302;3.25e-05)|Colorectal(196;3.46e-05)|Ovarian(999;0.00327)		all cancers(137;2.54e-48)|Epithelial(106;3.11e-44)|OV - Ovarian serous cystadenocarcinoma(136;2.08e-24)|BRCA - Breast invasive adenocarcinoma(108;0.000141)|GBM - Glioblastoma multiforme(226;0.00046)		GTAAACTTGTCTGAAATGATG	0.517			NA											32	125					2.32173e-10	3.22656e-10	0.004878	1	0
RFX6	222546	broad.mit.edu	37	6	117237403	117237403	+	Missense_Mutation	SNP	G	G	T	rs146184246		TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr6:117237403G>T	uc003pxm.2	+	9	961	c.898G>T	c.(898-900)GAC>TAC	p.D300Y		NM_173560	NP_775831	Q8HWS3	RFX6_HUMAN	regulatory factor X, 6	300					glucose homeostasis|pancreatic A cell differentiation|pancreatic D cell differentiation|pancreatic E cell differentiation|positive regulation of transcription, DNA-dependent|regulation of insulin secretion|transcription, DNA-dependent|type B pancreatic cell differentiation	nucleus	protein binding|transcription regulatory region DNA binding			ovary(1)|pancreas(1)|skin(1)	3						AGGAATGCCTGACCATCTCCT	0.338			NA											36	85					3.54561e-26	6.22469e-26	0.009718	1	0
MAN1A1	4121	broad.mit.edu	37	6	119669822	119669822	+	Nonsense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr6:119669822C>A	uc003pym.1	-	2	851	c.409G>T	c.(409-411)GAG>TAG	p.E137*	MAN1A1_uc010kei.1_Nonsense_Mutation_p.E137*	NM_005907	NP_005898	P33908	MA1A1_HUMAN	mannosidase, alpha, class 1A, member 1	137	Lumenal (Potential).				post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum|ER-Golgi intermediate compartment|Golgi membrane|integral to membrane|membrane fraction	calcium ion binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity			ovary(2)|central_nervous_system(1)|skin(1)	4		all_epithelial(87;0.173)		OV - Ovarian serous cystadenocarcinoma(136;0.0612)|GBM - Glioblastoma multiforme(226;0.0702)|all cancers(137;0.115)		TGCAGGGTCTCCTTGGCTTCC	0.617	Ovarian(136;8 1825 12608 33541 47587)		NA											9	39					9.70103e-10	1.33322e-09	0.008291	1	0
THEMIS	387357	broad.mit.edu	37	6	128134522	128134522	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr6:128134522C>G	uc003qbi.2	-	5	1583	c.1264G>C	c.(1264-1266)GAG>CAG	p.E422Q	THEMIS_uc010kfa.2_Missense_Mutation_p.E325Q|THEMIS_uc011ebt.1_Missense_Mutation_p.E422Q|THEMIS_uc010kfb.2_Missense_Mutation_p.E387Q	NM_001010923	NP_001010923	Q8N1K5	THMS1_HUMAN	thymocyte selection pathway associated isoform	422	CABIT 2.				negative T cell selection|positive T cell selection|T cell receptor signaling pathway	cytoplasm|nucleus				ovary(2)|skin(2)	4						AGCGCAGCCTCATAGGACTTT	0.438			NA											14	35					0	0	0.003163	0	0
THEMIS	387357	broad.mit.edu	37	6	128134779	128134779	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr6:128134779G>T	uc003qbi.2	-	5	1326	c.1007C>A	c.(1006-1008)ACT>AAT	p.T336N	THEMIS_uc010kfa.2_Missense_Mutation_p.T239N|THEMIS_uc011ebt.1_Missense_Mutation_p.T336N|THEMIS_uc010kfb.2_Missense_Mutation_p.T301N	NM_001010923	NP_001010923	Q8N1K5	THMS1_HUMAN	thymocyte selection pathway associated isoform	336	CABIT 2.				negative T cell selection|positive T cell selection|T cell receptor signaling pathway	cytoplasm|nucleus				ovary(2)|skin(2)	4						TTTATAGCTAGTGGGGATCAA	0.468			NA											11	41					0.000151284	0.000170553	0.001855	1	0
LAMA2	3908	broad.mit.edu	37	6	129573242	129573242	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr6:129573242G>T	uc003qbn.2	+	14	2003	c.1898G>T	c.(1897-1899)AGC>ATC	p.S633I	LAMA2_uc003qbo.2_Missense_Mutation_p.S633I	NM_000426	NP_000417	P24043	LAMA2_HUMAN	laminin alpha 2 subunit isoform a precursor	633	Laminin IV type A 1.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|breast(1)|skin(1)	10				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		AATGACTTGAGCATCAGCACA	0.358			NA											5	24					3.59834e-05	4.13823e-05	0.001168	1	0
LAMA2	3908	broad.mit.edu	37	6	129618855	129618855	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr6:129618855C>A	uc003qbn.2	+	21	2987	c.2882C>A	c.(2881-2883)GCA>GAA	p.A961E	LAMA2_uc003qbo.2_Missense_Mutation_p.A961E	NM_000426	NP_000417	P24043	LAMA2_HUMAN	laminin alpha 2 subunit isoform a precursor	961	Laminin EGF-like 9.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|breast(1)|skin(1)	10				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		CTACAATCAGCAAGGGGCTGT	0.453			NA											8	49					1.58986e-06	1.94739e-06	0.008291	1	0
MOXD1	26002	broad.mit.edu	37	6	132695876	132695876	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr6:132695876G>A	uc003qdf.2	-	2	404	c.305C>T	c.(304-306)GCT>GTT	p.A102V	MOXD1_uc003qde.2_Missense_Mutation_p.A34V	NM_015529	NP_056344	Q6UVY6	MOXD1_HUMAN	monooxygenase, DBH-like 1 isoform 2	102	Lumenal (Potential).|DOMON.				catecholamine metabolic process	endoplasmic reticulum membrane|integral to membrane	copper ion binding|dopamine beta-monooxygenase activity			ovary(1)	1	Breast(56;0.0495)			OV - Ovarian serous cystadenocarcinoma(155;0.0132)|GBM - Glioblastoma multiforme(226;0.0191)		ATCTTGCTGAGCATCTTTTTT	0.323			NA											11	34					0	0	0.008291	0	0
TCF21	6943	broad.mit.edu	37	6	134210578	134210578	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr6:134210578G>T	uc003qei.3	+	1	319	c.43G>T	c.(43-45)GTG>TTG	p.V15L	uc003qeg.1_5'Flank|TCF21_uc003qej.2_Missense_Mutation_p.V15L	NM_003206	NP_003197	O43680	TCF21_HUMAN	transcription factor 21	15					branching involved in ureteric bud morphogenesis|mesoderm development|negative regulation of androgen receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent	nucleus	androgen receptor binding|E-box binding|protein dimerization activity|sequence-specific DNA binding transcription factor activity				0	Colorectal(23;0.221)|Breast(56;0.247)			GBM - Glioblastoma multiforme(68;0.00518)|OV - Ovarian serous cystadenocarcinoma(155;0.00783)		CCTTCAAGAGGTGGAGATGTT	0.423			NA											32	81					3.21399e-22	5.4682e-22	0.004878	1	0
GPR126	57211	broad.mit.edu	37	6	142732545	142732545	+	Silent	SNP	G	G	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr6:142732545G>A	uc010khc.2	+	18	2949	c.2538G>A	c.(2536-2538)CTG>CTA	p.L846L	GPR126_uc010khd.2_Silent_p.L818L|GPR126_uc010khe.2_Silent_p.L846L|GPR126_uc010khf.2_Silent_p.L818L	NM_020455	NP_065188	Q86SQ4	GP126_HUMAN	G protein-coupled receptor 126 alpha 1	846	GPS.|Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(1)	1	Breast(32;0.176)			OV - Ovarian serous cystadenocarcinoma(155;9.33e-06)|GBM - Glioblastoma multiforme(68;0.00121)		TTGGAGTTCTGATGGTAAGGG	0.403			NA											17	106					0	0	0.007413	0	0
LATS1	9113	broad.mit.edu	37	6	150001244	150001244	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr6:150001244C>A	uc003qmu.1	-	5	2908	c.2360G>T	c.(2359-2361)GGG>GTG	p.G787V	LATS1_uc010kif.1_Missense_Mutation_p.G682V|LATS1_uc003qmv.1_Missense_Mutation_p.G787V	NM_004690	NP_004681	O95835	LATS1_HUMAN	LATS homolog 1	787	Protein kinase.				cell division|cytoplasmic sequestering of protein|G2/M transition of mitotic cell cycle|hippo signaling cascade|hormone-mediated signaling pathway|mitosis|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cyclin-dependent protein kinase activity|positive regulation of peptidyl-serine phosphorylation|regulation of actin filament polymerization|sister chromatid segregation	microtubule organizing center|spindle pole	ATP binding|magnesium ion binding|protein kinase binding|protein serine/threonine kinase activity			lung(5)|central_nervous_system(1)	6		Ovarian(120;0.0164)		OV - Ovarian serous cystadenocarcinoma(155;6.93e-13)|GBM - Glioblastoma multiforme(68;0.116)		CATATCACCCCCAGGAATGTA	0.388			NA											21	77					1.50039e-11	2.15148e-11	0.001882	1	0
NUP43	348995	broad.mit.edu	37	6	150057682	150057682	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr6:150057682C>G	uc003qmz.2	-	6	772	c.715G>C	c.(715-717)GAT>CAT	p.D239H	NUP43_uc003qmx.3_RNA|NUP43_uc011eee.1_RNA|NUP43_uc011eef.1_Intron	NM_198887	NP_942590	Q8NFH3	NUP43_HUMAN	nucleoporin 43kDa	239	WD 5.				carbohydrate metabolic process|cell division|chromosome segregation|glucose transport|mitotic prometaphase|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytosol|Nup107-160 complex	protein binding			upper_aerodigestive_tract(1)	1		Ovarian(120;0.0164)		OV - Ovarian serous cystadenocarcinoma(155;4.71e-13)|GBM - Glioblastoma multiforme(68;0.101)		AACATTCCATCTTGGCCACCA	0.448			NA											11	36					0	0	0.001368	0	0
AKAP12	9590	broad.mit.edu	37	6	151672116	151672116	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr6:151672116C>A	uc011eep.1	+	4	2830	c.2590C>A	c.(2590-2592)CAA>AAA	p.Q864K	AKAP12_uc003qoe.2_Missense_Mutation_p.Q864K|AKAP12_uc003qof.2_Missense_Mutation_p.Q766K|AKAP12_uc010kim.2_Intron|AKAP12_uc003qog.2_Missense_Mutation_p.Q759K	NM_005100	NP_005091	Q02952	AKA12_HUMAN	A kinase (PRKA) anchor protein 12 isoform 1	864					G-protein coupled receptor protein signaling pathway|positive regulation of cAMP biosynthetic process|positive regulation of protein kinase A signaling cascade|protein targeting	cell cortex|cytoskeleton|plasma membrane	adenylate cyclase binding|protein kinase A binding			large_intestine(2)|ovary(2)|upper_aerodigestive_tract(1)|lung(1)|skin(1)|pancreas(1)	8		Ovarian(120;0.125)	BRCA - Breast invasive adenocarcinoma(37;0.175)	OV - Ovarian serous cystadenocarcinoma(155;2.98e-11)		GGAGGCACAGCAAGCCCAAAA	0.577	Melanoma(141;1616 1805 10049 24534 51979)		NA											12	64					0.00136819	0.0014818	0.001368	1	0
CLDN20	49861	broad.mit.edu	37	6	155597019	155597019	+	Missense_Mutation	SNP	T	T	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr6:155597019T>A	uc003qql.1	+	2	546	c.166T>A	c.(166-168)TGG>AGG	p.W56R	TFB1M_uc003qqj.3_Intron|TFB1M_uc003qqk.2_Intron	NM_001001346	NP_001001346	P56880	CLD20_HUMAN	claudin 20	56	Extracellular (Potential).				calcium-independent cell-cell adhesion|tight junction assembly	integral to membrane|tight junction	identical protein binding|structural molecule activity				0				OV - Ovarian serous cystadenocarcinoma(155;7.82e-13)|BRCA - Breast invasive adenocarcinoma(81;0.0114)		GGACTGTACGTGGTACAGCAC	0.567			NA											27	51					0	0	0.003271	0	0
ZDHHC14	79683	broad.mit.edu	37	6	158053870	158053871	+	Nonsense_Mutation	DNP	AC	AC	TT			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	AC	AC	-	-	AC	AC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr6:158053870_158053871AC>TT	uc003qqt.2	+	5	1205_1206	c.708_709AC>TT	c.(706-711)TCACAG>TCTTAG	p.Q237*	ZDHHC14_uc003qqs.2_Nonsense_Mutation_p.Q237*|ZDHHC14_uc003qqu.1_RNA	NM_024630	NP_078906	Q8IZN3	ZDH14_HUMAN	zinc finger, DHHC-type containing 14 isoform 1	237						integral to membrane	acyltransferase activity|zinc ion binding			ovary(1)|skin(1)	2		Breast(66;0.00586)|Ovarian(120;0.123)		OV - Ovarian serous cystadenocarcinoma(65;2.9e-17)|BRCA - Breast invasive adenocarcinoma(81;5.8e-05)		CCACAGGTTCACAGCAAACAGG	0.391			NA											76	228					0	0	0.004672	0	0
IGF2R	3482	broad.mit.edu	37	6	160430102	160430102	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr6:160430102G>C	uc003qta.2	+	3	498	c.350G>C	c.(349-351)TGT>TCT	p.C117S		NM_000876	NP_000867	P11717	MPRI_HUMAN	insulin-like growth factor 2 receptor precursor	117	1.|Lumenal (Potential).				receptor-mediated endocytosis	cell surface|endocytic vesicle|endosome|integral to plasma membrane|lysosomal membrane|trans-Golgi network transport vesicle	glycoprotein binding|insulin-like growth factor receptor activity|phosphoprotein binding|transporter activity			ovary(3)	3		Breast(66;0.000777)|Ovarian(120;0.0305)		OV - Ovarian serous cystadenocarcinoma(65;2.45e-17)|BRCA - Breast invasive adenocarcinoma(81;1.09e-05)		ACAGTGAGCTGTGACCAGCAA	0.448			NA											31	42					0	0	0.002445	0	0
PARK2	5071	broad.mit.edu	37	6	161969912	161969912	+	Nonsense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr6:161969912C>A	uc003qtx.3	-	9	1191	c.1057G>T	c.(1057-1059)GAA>TAA	p.E353*	PARK2_uc003qtv.3_Intron|PARK2_uc010kkd.2_Nonsense_Mutation_p.E162*|PARK2_uc003qtw.3_Nonsense_Mutation_p.E162*|PARK2_uc003qty.3_Nonsense_Mutation_p.E325*|PARK2_uc003qtz.3_Nonsense_Mutation_p.E204*|PARK2_uc010kke.1_Nonsense_Mutation_p.E372*|PARK2_uc011egf.1_Nonsense_Mutation_p.E27*	NM_004562	NP_004553	O60260	PRKN2_HUMAN	parkin isoform 1	353	IBR-type.				aggresome assembly|central nervous system development|mitochondrion degradation|negative regulation of actin filament bundle assembly|negative regulation of cell death|negative regulation of protein phosphorylation|negative regulation of release of cytochrome c from mitochondria|neuron death|positive regulation of I-kappaB kinase/NF-kappaB cascade|protein autoubiquitination|protein K48-linked ubiquitination|protein K63-linked ubiquitination|protein monoubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|regulation of autophagy|regulation of reactive oxygen species metabolic process	aggresome|cytosol|endoplasmic reticulum|Golgi apparatus|mitochondrion|nucleus|perinuclear region of cytoplasm	chaperone binding|PDZ domain binding|protein kinase binding|ubiquitin protein ligase binding|ubiquitin-protein ligase activity|zinc ion binding			upper_aerodigestive_tract(1)	1		all_cancers(1;8.13e-65)|all_epithelial(1;5.77e-64)|Colorectal(1;9.65e-15)|all_lung(1;1.66e-13)|Lung NSC(1;7.54e-11)|Melanoma(1;1.75e-09)|Breast(66;7.81e-05)|Ovarian(120;0.000981)|Prostate(117;0.0288)|Esophageal squamous(34;0.102)		UCEC - Uterine corpus endometrioid carcinoma (4;0.0663)|all cancers(1;1.9e-63)|Epithelial(1;1.5e-59)|Colorectal(1;2.16e-23)|OV - Ovarian serous cystadenocarcinoma(65;3.53e-20)|COAD - Colon adenocarcinoma(1;2.11e-15)|STAD - Stomach adenocarcinoma(1;4.64e-07)|BRCA - Breast invasive adenocarcinoma(81;1.49e-06)|READ - Rectum adenocarcinoma(1;2.95e-06)|GBM - Glioblastoma multiforme(2;7.23e-06)|Lung(1;0.00163)|KIRC - Kidney renal clear cell carcinoma(4;0.00371)|LUSC - Lung squamous cell carcinoma(1;0.00442)|Kidney(4;0.0046)		TTGCCCCCTTCGCAGGTGACT	0.622			NA											45	107					2.65591e-33	4.7755e-33	0.00361	1	0
FGFR1OP	11116	broad.mit.edu	37	6	167416710	167416710	+	Silent	SNP	G	G	C			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr6:167416710G>C	uc003qvj.2	+	3	271	c.186G>C	c.(184-186)CTG>CTC	p.L62L	CCR6_uc003qvl.2_5'UTR|FGFR1OP_uc011egp.1_Silent_p.L62L|FGFR1OP_uc003qvk.2_Silent_p.L62L	NM_007045	NP_008976	O95684	FR1OP_HUMAN	FGFR1 oncogene partner isoform a	62					G2/M transition of mitotic cell cycle|microtubule anchoring|positive regulation of cell growth|positive regulation of cell migration|positive regulation of cell proliferation	centrosome|cytosol|nucleus|perinuclear region of cytoplasm	protein homodimerization activity|protein kinase binding|protein tyrosine kinase inhibitor activity			ovary(1)	1		Breast(66;1.48e-05)|Ovarian(120;0.0607)		OV - Ovarian serous cystadenocarcinoma(33;1.73e-19)|BRCA - Breast invasive adenocarcinoma(81;5.1e-06)|GBM - Glioblastoma multiforme(31;0.00231)		ATGAGAGCCTGAAAAAGTTTT	0.284			NA	T	FGFR1	MPD|NHL								4	19					0	0	0.009096	0	0
UNC93A	54346	broad.mit.edu	37	6	167721356	167721356	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr6:167721356C>A	uc003qvq.2	+	7	1241	c.1066C>A	c.(1066-1068)CTG>ATG	p.L356M	UNC93A_uc003qvr.2_Missense_Mutation_p.L314M	NM_018974	NP_061847	Q86WB7	UN93A_HUMAN	unc-93 homolog A isoform 1	356	Helical; (Potential).					integral to membrane|plasma membrane					0		Breast(66;7.62e-05)|Ovarian(120;0.105)		OV - Ovarian serous cystadenocarcinoma(33;2.22e-20)|BRCA - Breast invasive adenocarcinoma(81;6.17e-07)|GBM - Glioblastoma multiforme(31;0.00492)		ATTCTCTGGCCTGTGGGGCGT	0.632			NA											7	48					2.7689e-08	3.62443e-08	0.001984	1	0
TBP	6908	broad.mit.edu	37	6	170871116	170871116	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr6:170871116G>A	uc003qxt.2	+	3	524	c.292G>A	c.(292-294)GCA>ACA	p.A98T	TBP_uc003qxu.2_Missense_Mutation_p.A98T|TBP_uc011ehf.1_Missense_Mutation_p.A78T|TBP_uc011ehg.1_Missense_Mutation_p.A98T	NM_003194	NP_003185	P20226	TBP_HUMAN	TATA box binding protein	98					cell death|interspecies interaction between organisms|transcription elongation from RNA polymerase II promoter|transcription from RNA polymerase III promoter|viral reproduction	transcription factor TFIIA complex|transcription factor TFIID complex	repressing transcription factor binding|transcription regulatory region DNA binding			ovary(1)	1		Breast(66;5.08e-05)|Ovarian(120;0.125)|Esophageal squamous(34;0.246)		OV - Ovarian serous cystadenocarcinoma(33;1.07e-22)|BRCA - Breast invasive adenocarcinoma(81;5.01e-06)|GBM - Glioblastoma multiforme(31;0.00591)		acaggcagtggcagctgcagc	0.264			NA											15	32					0	0	0.004007	0	0
SDK1	221935	broad.mit.edu	37	7	4281481	4281481	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr7:4281481G>T	uc003smx.2	+	43	6326	c.6187G>T	c.(6187-6189)GCC>TCC	p.A2063S	SDK1_uc010kso.2_Missense_Mutation_p.A1319S|SDK1_uc003smy.2_Missense_Mutation_p.A550S|SDK1_uc003smz.2_Missense_Mutation_p.A123S	NM_152744	NP_689957	Q7Z5N4	SDK1_HUMAN	sidekick 1 precursor	2063	Extracellular (Potential).|Cytoplasmic (Potential).				cell adhesion	integral to membrane				large_intestine(3)|ovary(2)|skin(1)	6		all_cancers(1;0.127)|Ovarian(82;0.0177)|Myeloproliferative disorder(862;0.194)		UCEC - Uterine corpus endometrioid carcinoma (126;0.121)|OV - Ovarian serous cystadenocarcinoma(56;9.65e-15)		AGGATTTGCTGCCCTGGAGCT	0.587			NA											8	27					1.76689e-08	2.32305e-08	0.006214	1	0
RADIL	55698	broad.mit.edu	37	7	4841357	4841357	+	Silent	SNP	G	G	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr7:4841357G>A	uc003snj.1	-	12	2942	c.2769C>T	c.(2767-2769)GGC>GGT	p.G923G	RADIL_uc003sng.1_RNA|RADIL_uc003sni.1_Silent_p.G428G|RADIL_uc011jwc.1_Silent_p.G683G|RADIL_uc011jwd.1_RNA|RADIL_uc003snh.1_Silent_p.G219G	NM_018059	NP_060529	Q96JH8	RADIL_HUMAN	Rap GTPase interactor	923	Pro-rich.				cell adhesion|multicellular organismal development|signal transduction		protein binding			lung(2)|central_nervous_system(2)|pancreas(2)|breast(1)	7		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0986)|OV - Ovarian serous cystadenocarcinoma(56;7.41e-15)		CACAGGGGCCGCCGGACTCTG	0.711			NA											3	4					0	0	0.004672	0	0
PAPOLB	56903	broad.mit.edu	37	7	4899793	4899793	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr7:4899793C>A	uc003snk.2	-	1	1833	c.1649G>T	c.(1648-1650)AGC>ATC	p.S550I	RADIL_uc003sng.1_Intron|RADIL_uc011jwd.1_Intron|RADIL_uc003snj.1_Intron	NM_020144	NP_064529	Q9NRJ5	PAPOB_HUMAN	poly(A) polymerase beta (testis specific)	549					mRNA processing|RNA polyadenylation|transcription, DNA-dependent	nucleus	ATP binding|metal ion binding|polynucleotide adenylyltransferase activity|RNA binding			ovary(1)	1		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.089)|OV - Ovarian serous cystadenocarcinoma(56;2.06e-14)		CTGAGAACTGCTAATCAATGG	0.453			NA											16	77					2.4624e-09	3.32569e-09	0.008871	1	0
USP42	84132	broad.mit.edu	37	7	6189538	6189538	+	Missense_Mutation	SNP	A	A	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr7:6189538A>T	uc011jwo.1	+	13	1834	c.1711A>T	c.(1711-1713)ACG>TCG	p.T571S	USP42_uc010kth.1_Missense_Mutation_p.T504S|USP42_uc011jwp.1_Missense_Mutation_p.T571S|USP42_uc011jwq.1_Missense_Mutation_p.T378S|USP42_uc011jwr.1_Missense_Mutation_p.T416S	NM_032172	NP_115548	Q9H9J4	UBP42_HUMAN	ubiquitin specific peptidase 42	571					cell differentiation|protein deubiquitination|spermatogenesis|ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity			skin(2)|ovary(1)|pancreas(1)|breast(1)	5		Ovarian(82;0.0423)		UCEC - Uterine corpus endometrioid carcinoma (126;0.108)|OV - Ovarian serous cystadenocarcinoma(56;5.77e-14)		GAACGCATCTACGATGTCAGT	0.478			NA											6	31					0	0	0.001168	0	0
DGKB	1607	broad.mit.edu	37	7	14378244	14378244	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr7:14378244C>A	uc003ssz.2	-	22	2208	c.2021G>T	c.(2020-2022)TGG>TTG	p.W674L	DGKB_uc011jxt.1_Missense_Mutation_p.W655L|DGKB_uc003sta.2_Missense_Mutation_p.W674L|DGKB_uc011jxu.1_Missense_Mutation_p.W673L	NM_004080	NP_004071	Q9Y6T7	DGKB_HUMAN	diacylglycerol kinase, beta isoform 1	674					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	cytoplasm|plasma membrane	ATP binding|calcium ion binding|diacylglycerol kinase activity|protein binding			lung(5)|ovary(4)|breast(2)|skin(1)	12					Phosphatidylserine(DB00144)	AGACTCTCCCCAAAGATTGGA	0.413			NA											14	38					1.52009e-12	2.25137e-12	0.003163	1	0
TMEM195	392636	broad.mit.edu	37	7	15599801	15599801	+	Silent	SNP	C	C	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr7:15599801C>T	uc003stb.1	-	2	392	c.222G>A	c.(220-222)ACG>ACA	p.T74T		NM_001004320	NP_001004320	Q6ZNB7	ALKMO_HUMAN	transmembrane protein 195	74					ether lipid metabolic process|fatty acid biosynthetic process|membrane lipid metabolic process	endoplasmic reticulum membrane|integral to membrane	glyceryl-ether monooxygenase activity|iron ion binding				0						CTGAGATTGACGTTAAAGCAT	0.453			NA											15	61					0	0	0.004007	0	0
HDAC9	9734	broad.mit.edu	37	7	18801852	18801852	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr7:18801852G>T	uc003suh.2	+	14	2148	c.2107G>T	c.(2107-2109)GGC>TGC	p.G703C	HDAC9_uc003sue.2_Missense_Mutation_p.G703C|HDAC9_uc011jyd.1_Missense_Mutation_p.G703C|HDAC9_uc003sui.2_Missense_Mutation_p.G706C|HDAC9_uc003suj.2_Missense_Mutation_p.G662C|HDAC9_uc003sua.1_Missense_Mutation_p.G681C	NM_058176	NP_478056	Q9UKV0	HDAC9_HUMAN	histone deacetylase 9 isoform 1	703	Histone deacetylase.				B cell differentiation|cellular response to insulin stimulus|heart development|histone H3 deacetylation|histone H4 deacetylation|inflammatory response|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|peptidyl-lysine deacetylation|positive regulation of cell migration involved in sprouting angiogenesis|regulation of skeletal muscle fiber development|transcription, DNA-dependent	cytoplasm|histone deacetylase complex|histone methyltransferase complex|transcription factor complex	histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|histone deacetylase binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|protein binding|protein kinase C binding|repressing transcription factor binding|transcription corepressor activity			lung(2)|central_nervous_system(2)|kidney(1)	5	all_lung(11;0.187)				Valproic Acid(DB00313)	ACTGTTGTATGGCACCAACCC	0.502			NA											8	24					3.09899e-07	3.88222e-07	0.004482	1	0
ABCB5	340273	broad.mit.edu	37	7	20698288	20698288	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr7:20698288G>C	uc003suw.3	+	5	907	c.361G>C	c.(361-363)GCA>CCA	p.A121P	ABCB5_uc010kuh.2_Missense_Mutation_p.A566P|ABCB5_uc003suv.3_Missense_Mutation_p.A121P|ABCB5_uc011jyi.1_Missense_Mutation_p.A121P	NM_178559	NP_848654	Q2M3G0	ABCB5_HUMAN	ATP-binding cassette, sub-family B, member 5	121	ABC transporter 1.|Extracellular (Potential).				regulation of membrane potential	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus	ATP binding|ATPase activity, coupled to transmembrane movement of substances|efflux transmembrane transporter activity			skin(2)|large_intestine(1)|haematopoietic_and_lymphoid_tissue(1)|ovary(1)|pancreas(1)	6						TGTTCAAGCTGCACTGGAGAA	0.408			NA											10	27					0	0	0.001855	0	0
SNX10	29887	broad.mit.edu	37	7	26400640	26400640	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr7:26400640G>T	uc003sxx.2	+	3	285	c.70G>T	c.(70-72)GAC>TAC	p.D24Y	SNX10_uc011jzg.1_Missense_Mutation_p.D47Y|SNX10_uc010kuu.2_Missense_Mutation_p.D24Y|SNX10_uc010kuv.2_Missense_Mutation_p.D20Y	NM_013322	NP_037454	Q9Y5X0	SNX10_HUMAN	sorting nexin 10	24	PX.				cell communication|endosome organization|protein transport	extrinsic to endosome membrane	1-phosphatidylinositol binding				0						TCAGAAGGAGGACTTCTGGCA	0.353			NA											23	57					2.41591e-17	3.89638e-17	0.004656	1	0
HOXA13	3209	broad.mit.edu	37	7	27237955	27237955	+	Silent	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr7:27237955C>A	uc003szb.1	-	2	1058	c.1029G>T	c.(1027-1029)ACG>ACT	p.T343T	uc003szc.1_5'Flank	NM_000522	NP_000513	P31271	HXA13_HUMAN	homeobox A13	343	Homeobox.				skeletal system development	nucleus	sequence-specific DNA binding			breast(1)	1						TGAATTTATTCGTGGCGTATT	0.498			NA	T	NUP98	AML						OREG0003748	type=REGULATORY REGION|Gene=HOXA13|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	42	108					2.52991e-16	4.0192e-16	0.00361	1	0
CREB5	9586	broad.mit.edu	37	7	28610146	28610146	+	Missense_Mutation	SNP	G	G	T	rs114450022	by1000genomes	TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr7:28610146G>T	uc003szq.2	+	5	845	c.455G>T	c.(454-456)CGC>CTC	p.R152L	CREB5_uc003szo.2_Missense_Mutation_p.R119L|CREB5_uc003szr.2_Missense_Mutation_p.R145L	NM_182898	NP_878901	Q02930	CREB5_HUMAN	cAMP responsive element binding protein 5	152					positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter		protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(2)	2						TCCACCAACCGCCAGATCGGG	0.587			NA											11	52					7.03913e-09	9.3457e-09	0.001368	1	0
AVL9	23080	broad.mit.edu	37	7	32598191	32598191	+	Silent	SNP	A	A	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr7:32598191A>T	uc003tcv.1	+	9	776	c.630A>T	c.(628-630)CCA>CCT	p.P210P	AVL9_uc011kai.1_Silent_p.P210P|AVL9_uc010kwj.1_Silent_p.P51P	NM_015060	NP_055875	Q8NBF6	AVL9_HUMAN	AVL9 homolog (S. cerevisiase)	210						integral to membrane					0						ATATTTCTCCAGTGAATAAAT	0.348			NA											9	32					0	0	0.008291	0	0
RP9	6100	broad.mit.edu	37	7	33136953	33136953	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr7:33136953C>A	uc003tdm.2	-	4	353	c.335G>T	c.(334-336)GGT>GTT	p.G112V		NM_203288	NP_976033	Q8TA86	RP9_HUMAN	retinitis pigmentosa 9	112	PIM1-binding (By similarity).|CCHC-type.				RNA splicing	nucleus	nucleic acid binding|protein binding|zinc ion binding				0			GBM - Glioblastoma multiforme(11;0.0403)			CGTTCGGTGACCATAGCGTTT	0.373			NA											17	36					3.41278e-10	4.72955e-10	0.00499	1	0
POU6F2	11281	broad.mit.edu	37	7	39379522	39379522	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr7:39379522C>A	uc003thb.1	+	5	835	c.793C>A	c.(793-795)CCA>ACA	p.P265T	POU6F2_uc010kxo.2_Missense_Mutation_p.P257T	NM_007252	NP_009183	P78424	PO6F2_HUMAN	POU class 6 homeobox 2 isoform 1	265	Pro-rich.|Gln-rich.				central nervous system development|ganglion mother cell fate determination|transcription from RNA polymerase II promoter|visual perception		sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)	1						ccaaccatctccaacccagca	0.224			NA											17	40					1.99824e-07	2.51812e-07	0.00499	1	0
INHBA	3624	broad.mit.edu	37	7	41729792	41729792	+	Missense_Mutation	SNP	T	T	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr7:41729792T>A	uc003thq.2	-	2	972	c.737A>T	c.(736-738)CAG>CTG	p.Q246L	INHBA_uc003thr.2_Missense_Mutation_p.Q246L	NM_002192	NP_002183	P08476	INHBA_HUMAN	inhibin beta A precursor	246					cell cycle arrest|cell surface receptor linked signaling pathway|defense response|erythrocyte differentiation|eyelid development in camera-type eye|G1/S transition of mitotic cell cycle|growth|hair follicle development|hemoglobin biosynthetic process|hemopoietic progenitor cell differentiation|induction of apoptosis|male gonad development|negative regulation of B cell differentiation|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of follicle-stimulating hormone secretion|negative regulation of interferon-gamma biosynthetic process|negative regulation of macrophage differentiation|negative regulation of phosphorylation|nervous system development|odontogenesis|ovarian follicle development|palate development|positive regulation of erythrocyte differentiation|positive regulation of follicle-stimulating hormone secretion|positive regulation of ovulation|positive regulation of transcription from RNA polymerase II promoter|progesterone secretion|regulation of activin receptor signaling pathway	activin A complex|inhibin A complex	cytokine activity|follistatin binding|growth factor activity|hormone activity|identical protein binding|signal transducer activity			lung(5)|ovary(1)	6						CTCCTGGCACTGCTCACAGGC	0.433			NA								TSP Lung(11;0.080)			8	27					0	0	0.008291	0	0
GLI3	2737	broad.mit.edu	37	7	42005524	42005524	+	Nonsense_Mutation	SNP	G	G	C			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr7:42005524G>C	uc011kbh.1	-	15	3238	c.3147C>G	c.(3145-3147)TAC>TAG	p.Y1049*	GLI3_uc011kbg.1_Nonsense_Mutation_p.Y990*	NM_000168	NP_000159	P10071	GLI3_HUMAN	GLI-Kruppel family member GLI3	1049					negative regulation of alpha-beta T cell differentiation|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of smoothened signaling pathway|negative regulation of transcription from RNA polymerase II promoter|negative thymic T cell selection|positive regulation of alpha-beta T cell differentiation|positive regulation of transcription from RNA polymerase II promoter|thymocyte apoptosis	cilium|cytosol|nucleolus	beta-catenin binding|histone acetyltransferase binding|histone deacetylase binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(11)|ovary(3)|large_intestine(2)|central_nervous_system(1)|kidney(1)|pancreas(1)	19						CGGGCCGCGTGTAATTCTGAA	0.667			NA							Greig_Cephalopolysyndactyly|Pallister-Hall_syndrome				6	33					0	0	0.001984	0	0
HECW1	23072	broad.mit.edu	37	7	43477686	43477686	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr7:43477686C>A	uc003tid.1	+	9	1491	c.886C>A	c.(886-888)CGC>AGC	p.R296S	HECW1_uc011kbi.1_Missense_Mutation_p.R296S|HECW1_uc003tie.1_Missense_Mutation_p.R328S	NM_015052	NP_055867	Q76N89	HECW1_HUMAN	NEDD4-like ubiquitin-protein ligase 1	296	C2.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	ubiquitin-protein ligase activity			ovary(8)|lung(6)|breast(4)|skin(4)|pancreas(1)	23						CATCATCAAGCGCTTCTTGGG	0.493			NA											11	38					5.50884e-06	6.54807e-06	0.001368	1	0
HECW1	23072	broad.mit.edu	37	7	43484345	43484345	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr7:43484345G>T	uc003tid.1	+	11	2179	c.1574G>T	c.(1573-1575)CGG>CTG	p.R525L	HECW1_uc011kbi.1_Missense_Mutation_p.R525L	NM_015052	NP_055867	Q76N89	HECW1_HUMAN	NEDD4-like ubiquitin-protein ligase 1	525					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	ubiquitin-protein ligase activity			ovary(8)|lung(6)|breast(4)|skin(4)|pancreas(1)	23						CTGCAGCTGCGGGCCTCGGTG	0.562			NA											4	8					0.00024832	0.000277424	0.009096	1	0
MRPS24	64951	broad.mit.edu	37	7	43906464	43906464	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr7:43906464C>A	uc003tit.1	-	4	389	c.338G>T	c.(337-339)CGG>CTG	p.R113L		NM_032014	NP_114403	Q96EL2	RT24_HUMAN	mitochondrial ribosomal protein S24 precursor	113					translation	mitochondrial large ribosomal subunit|mitochondrial small ribosomal subunit	protein binding|structural constituent of ribosome				0						CTGGTTACCCCGGCGCTTTAA	0.547			NA											7	59					0.00307968	0.00328514	0.00308	1	0
URGCP	55665	broad.mit.edu	37	7	43917515	43917515	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr7:43917515C>G	uc003tiw.2	-	6	1604	c.1547G>C	c.(1546-1548)TGG>TCG	p.W516S	URGCP_uc003tiu.2_Missense_Mutation_p.W473S|URGCP_uc003tiv.2_Missense_Mutation_p.W441S|URGCP_uc003tix.2_Missense_Mutation_p.W507S|URGCP_uc003tiy.2_Missense_Mutation_p.W473S|URGCP_uc003tiz.2_Missense_Mutation_p.W473S|URGCP_uc011kbj.1_Missense_Mutation_p.W473S	NM_001077663	NP_001071131	Q8TCY9	URGCP_HUMAN	up-regulated gene 4 isoform 3	516				W -> R (in Ref. 3; CAE45880).	cell cycle	centrosome|nucleus	GTP binding			ovary(2)|liver(1)|skin(1)	4						GTCCACGGCCCACTGGAGCTG	0.627			NA											15	38					0	0	0.00499	0	0
MYO1G	64005	broad.mit.edu	37	7	45007525	45007525	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr7:45007525C>G	uc003tmh.2	-	13	1751	c.1607G>C	c.(1606-1608)AGA>ACA	p.R536T	MYO1G_uc003tmf.2_5'UTR|MYO1G_uc003tmg.2_Missense_Mutation_p.R298T|MYO1G_uc010kym.2_Missense_Mutation_p.R421T|MYO1G_uc003tmi.1_Missense_Mutation_p.R448T	NM_033054	NP_149043	B0I1T2	MYO1G_HUMAN	myosin IG	536	Myosin head-like.					myosin complex|plasma membrane	actin binding|ATP binding|calmodulin binding|motor activity			breast(2)|ovary(1)|pancreas(1)	4						GAGGAAATCTCTGTTCTTGTC	0.622			NA											10	24					0	0	0.001368	0	0
SEPT14	346288	broad.mit.edu	37	7	55874857	55874857	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr7:55874857G>T	uc003tqz.2	-	8	1029	c.912C>A	c.(910-912)CAC>CAA	p.H304Q		NM_207366	NP_997249	Q6ZU15	SEP14_HUMAN	septin 14	304					cell cycle|cell division	septin complex	GTP binding|protein binding				0	Breast(14;0.214)		Lung(13;0.00024)|LUSC - Lung squamous cell carcinoma(13;0.00099)			AACATTCATAGTGCTGAGTGT	0.378			NA											10	38					1.08611e-07	1.38156e-07	0.000978	1	0
WBSCR17	64409	broad.mit.edu	37	7	70880961	70880961	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr7:70880961C>A	uc003tvy.2	+	4	676	c.676C>A	c.(676-678)CTG>ATG	p.L226M	WBSCR17_uc003tvz.2_Translation_Start_Site	NM_022479	NP_071924	Q6IS24	GLTL3_HUMAN	UDP-GalNAc:polypeptide	226	Catalytic subdomain A.|Lumenal (Potential).					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			skin(3)|upper_aerodigestive_tract(1)|ovary(1)|pancreas(1)|central_nervous_system(1)	7		all_cancers(73;0.2)|Lung NSC(55;0.094)|all_lung(88;0.125)				GAGGGAAGGCCTGATCCGCGC	0.567			NA											22	44					2.44723e-14	3.72852e-14	0.004656	1	0
GTF2IP1	2970	broad.mit.edu	37	7	72617495	72617495	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr7:72617495G>T	uc003txo.3	+	21	2364	c.1483G>T	c.(1483-1485)GTG>TTG	p.V495L	FKBP6_uc003twz.2_Intron|GTF2IP1_uc011keq.1_Missense_Mutation_p.V495L	NR_003580				SubName: Full=cDNA FLJ61347, highly similar to General transcription factor II-I;												0						AAAAGGCCCCGTGATACAAGG	0.512			NA											29	85					3.03874e-20	5.04309e-20	0.003271	1	0
TBL2	26608	broad.mit.edu	37	7	72988399	72988399	+	Silent	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr7:72988399C>A	uc003tyh.2	-	3	449	c.315G>T	c.(313-315)CTG>CTT	p.L105L	TBL2_uc011kex.1_Silent_p.L69L|TBL2_uc010lbg.2_Silent_p.L10L|TBL2_uc003tyi.2_5'UTR|TBL2_uc011key.1_Intron|TBL2_uc010lbh.2_Silent_p.L10L	NM_012453	NP_036585	Q9Y4P3	TBL2_HUMAN	transducin (beta)-like 2	105	WD 1.										0		Lung NSC(55;0.0659)|all_lung(88;0.152)				CACAGGTAGCCAGGTATTTGC	0.572			NA											10	44					4.3838e-07	5.45499e-07	0.001855	1	0
LAT2	7462	broad.mit.edu	37	7	73634097	73634097	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr7:73634097C>A	uc003uag.2	+	5	708	c.158C>A	c.(157-159)ACG>AAG	p.T53K	RFC2_uc011kfa.1_Intron|LAT2_uc003uah.2_Missense_Mutation_p.T53K|LAT2_uc003uai.2_Missense_Mutation_p.T53K|LAT2_uc010lbo.2_RNA	NM_032464	NP_115853	Q9GZY6	NTAL_HUMAN	linker for activation of T cells family member	53	Cytoplasmic (Potential).				B cell activation|B cell receptor signaling pathway|calcium-mediated signaling|mast cell degranulation	integral to membrane|intracellular|membrane raft|plasma membrane	SH2 domain binding				0						CAGAGCTTTACGGGGTCCCGG	0.607			NA											51	152					5.5144e-22	9.37134e-22	0.00361	1	0
POR	5447	broad.mit.edu	37	7	75608896	75608896	+	Missense_Mutation	SNP	T	T	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr7:75608896T>A	uc003udy.2	+	4	447	c.365T>A	c.(364-366)CTG>CAG	p.L122Q	POR_uc011kgb.1_RNA|POR_uc011kgc.1_5'Flank|POR_uc011kgd.1_5'Flank|POR_uc011kge.1_5'Flank	NM_000941	NP_000932	P16435	NCPR_HUMAN	cytochrome P450 reductase	119	Flavodoxin-like.				cellular organofluorine metabolic process|positive regulation of monooxygenase activity	endoplasmic reticulum membrane	iron ion binding|NADPH-hemoprotein reductase activity			central_nervous_system(1)	1					Benzphetamine(DB00865)|Daunorubicin(DB00694)|Lipoic Acid(DB00166)|Menadione(DB00170)|Methoxyflurane(DB01028)|Mitomycin(DB00305)|Nilutamide(DB00665)	GAGTATGACCTGGTAAGCTGC	0.667			NA											19	50					0	0	0.00278	0	0
MAGI2	9863	broad.mit.edu	37	7	77762304	77762304	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr7:77762304C>A	uc003ugx.2	-	18	3359	c.3105G>T	c.(3103-3105)CAG>CAT	p.Q1035H	MAGI2_uc003ugy.2_Missense_Mutation_p.Q1021H|MAGI2_uc010ldx.1_Missense_Mutation_p.Q628H	NM_012301	NP_036433	Q86UL8	MAGI2_HUMAN	membrane associated guanylate kinase, WW and PDZ	1035	Pro-rich.					cell junction|synapse|synaptosome	phosphatase binding			ovary(5)|lung(4)|breast(1)|skin(1)	11		all_cancers(73;0.0064)|all_epithelial(88;0.087)|all_neural(109;0.0936)|Medulloblastoma(109;0.166)|Melanoma(862;0.236)				GGGGACTCTGCTGTGCCAGGG	0.627			NA											74	160					2.34191e-24	4.04462e-24	0.00361	1	0
ABCB1	5243	broad.mit.edu	37	7	87160718	87160718	+	Silent	SNP	C	C	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr7:87160718C>T	uc003uiz.1	-	22	2995	c.2577G>A	c.(2575-2577)CTG>CTA	p.L859L	ABCB1_uc011khc.1_Silent_p.L795L	NM_000927	NP_000918	P08183	MDR1_HUMAN	ATP-binding cassette, subfamily B, member 1	859	ABC transmembrane type-1 2.|Helical; (Potential).				G2/M transition of mitotic cell cycle|stem cell proliferation	apical plasma membrane|cell surface|Golgi membrane|integral to membrane|intercellular canaliculus|membrane fraction	ATP binding|protein binding|xenobiotic-transporting ATPase activity			ovary(4)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	7	Esophageal squamous(14;0.00164)				Adenosine triphosphate(DB00171)|Alfentanil(DB00802)|Arsenic trioxide(DB01169)|Atazanavir(DB01072)|Carvedilol(DB01136)|Colchicine(DB01394)|Cyclosporine(DB00091)|Daunorubicin(DB00694)|Dipyridamole(DB00975)|Estramustine(DB01196)|Flupenthixol(DB00875)|Imatinib(DB00619)|Itraconazole(DB01167)|Nicardipine(DB00622)|Propafenone(DB01182)|Quinacrine(DB01103)|Quinidine(DB00908)|Ranolazine(DB00243)|Rifampin(DB01045)|Roxithromycin(DB00778)|Saquinavir(DB01232)|Tamoxifen(DB00675)|Vinblastine(DB00570)	CTAAGAGTAACAGTGTTAGTT	0.383			NA											23	73					0	0	0.002299	0	0
RUNDC3B	154661	broad.mit.edu	37	7	87407136	87407136	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr7:87407136G>C	uc003ujb.2	+	9	1283	c.872G>C	c.(871-873)CGA>CCA	p.R291P	RUNDC3B_uc011khd.1_Missense_Mutation_p.R274P|RUNDC3B_uc011khe.1_Missense_Mutation_p.R274P|RUNDC3B_uc003ujc.2_Missense_Mutation_p.R274P|RUNDC3B_uc003ujd.2_Missense_Mutation_p.R196P	NM_138290	NP_612147	Q96NL0	RUN3B_HUMAN	RUN domain containing 3B isoform a	291										skin(1)	1	Esophageal squamous(14;0.00164)					GAACTCTTACGACTTCGAGAG	0.368			NA											10	17					0	0	0.00245	0	0
ZNF804B	219578	broad.mit.edu	37	7	88847495	88847495	+	Silent	SNP	A	A	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr7:88847495A>T	uc011khi.1	+	2	673	c.135A>T	c.(133-135)GCA>GCT	p.A45A		NM_181646	NP_857597	A4D1E1	Z804B_HUMAN	zinc finger protein 804B	45						intracellular	zinc ion binding			ovary(5)|skin(3)|pancreas(2)|upper_aerodigestive_tract(1)	11	all_hematologic(106;0.125)|Lung NSC(181;0.15)|all_lung(186;0.151)		STAD - Stomach adenocarcinoma(171;0.0513)			AGTCCACAGCAAAGGCCCTGG	0.348			NA								HNSCC(36;0.09)			13	31					0	0	0.00245	0	0
ZNF804B	219578	broad.mit.edu	37	7	88963101	88963101	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr7:88963101G>C	uc011khi.1	+	4	1343	c.805G>C	c.(805-807)GCA>CCA	p.A269P		NM_181646	NP_857597	A4D1E1	Z804B_HUMAN	zinc finger protein 804B	269						intracellular	zinc ion binding			ovary(5)|skin(3)|pancreas(2)|upper_aerodigestive_tract(1)	11	all_hematologic(106;0.125)|Lung NSC(181;0.15)|all_lung(186;0.151)		STAD - Stomach adenocarcinoma(171;0.0513)			CTGCAGGTTTGCAAATAAAGA	0.358			NA								HNSCC(36;0.09)			16	17					0	0	0.00499	0	0
CCDC132	55610	broad.mit.edu	37	7	92887685	92887685	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr7:92887685G>C	uc003umo.2	+	8	685	c.557G>C	c.(556-558)CGG>CCG	p.R186P	CCDC132_uc003umq.2_RNA|CCDC132_uc003ump.2_Missense_Mutation_p.R156P|CCDC132_uc003umr.2_RNA|CCDC132_uc011khz.1_Intron|CCDC132_uc003umn.2_Missense_Mutation_p.R186P	NM_017667	NP_060137	Q96JG6	CC132_HUMAN	coiled-coil domain containing 132 isoform a	186											0	all_cancers(62;2.64e-11)|all_epithelial(64;1.4e-10)|Breast(17;0.000675)|Lung NSC(181;0.0618)|all_lung(186;0.0837)		STAD - Stomach adenocarcinoma(171;0.000302)			ACAGATGTACGGTTAAGTGAA	0.299			NA											22	66					0	0	0.005443	0	0
SLC25A13	10165	broad.mit.edu	37	7	95775939	95775939	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr7:95775939C>G	uc003uof.3	-	14	1572	c.1381G>C	c.(1381-1383)GAA>CAA	p.E461Q	SLC25A13_uc003uog.3_Missense_Mutation_p.E462Q|SLC25A13_uc011kik.1_Missense_Mutation_p.E353Q	NM_014251	NP_055066	Q9UJS0	CMC2_HUMAN	solute carrier family 25, member 13 isoform 2	461	Solcar 2.				ATP biosynthetic process|gluconeogenesis|malate-aspartate shuttle|response to calcium ion	integral to plasma membrane|mitochondrial inner membrane	calcium ion binding|L-aspartate transmembrane transporter activity|L-glutamate transmembrane transporter activity			central_nervous_system(3)|skin(1)	4	all_cancers(62;7.75e-08)|all_epithelial(64;1.16e-07)		STAD - Stomach adenocarcinoma(171;0.194)		L-Aspartic Acid(DB00128)	GTGGTGATTTCTCCTGCCACT	0.413			NA											64	129					0	0	0.00361	0	0
TAC1	6863	broad.mit.edu	37	7	97365653	97365653	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr7:97365653C>G	uc003uop.3	+	6	578	c.332C>G	c.(331-333)GCT>GGT	p.A111G	TAC1_uc003uoq.3_Intron|TAC1_uc003uor.3_Missense_Mutation_p.A96G|TAC1_uc003uos.3_Intron	NM_003182	NP_003173	P20366	TKN1_HUMAN	tachykinin 1 isoform beta precursor	111					detection of abiotic stimulus|elevation of cytosolic calcium ion concentration|insemination|neuropeptide signaling pathway|synaptic transmission|tachykinin receptor signaling pathway	extracellular space					0	all_cancers(62;3.95e-09)|all_epithelial(64;1.1e-09)|Esophageal squamous(72;0.00448)|Lung NSC(181;0.0358)|all_lung(186;0.0384)				Bacitracin(DB00626)	GGCAAAAGAGCTTTAAATTCT	0.269			NA											21	49					0	0	0.002299	0	0
OCM2	4951	broad.mit.edu	37	7	97617759	97617759	+	Nonsense_Mutation	SNP	G	G	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr7:97617759G>A	uc003upc.2	-	2	163	c.163C>T	c.(163-165)CAG>TAG	p.Q55*		NM_006188	NP_006179	P0CE71	OCM2_HUMAN	oncomodulin-like	55	EF-hand 1.|1 (Potential).						calcium ion binding				0						TACCCGCTCTGGTCGTTGTCT	0.542			NA											27	49					0	0	0.009535	0	0
OCM2	4951	broad.mit.edu	37	7	97619394	97619394	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr7:97619394C>A	uc003upc.2	-	1	23	c.23G>T	c.(22-24)AGT>ATT	p.S8I		NM_006188	NP_006179	P0CE71	OCM2_HUMAN	oncomodulin-like	8							calcium ion binding				0						GTCATCAGCACTGAGCACGTC	0.552			NA											18	43					1.85244e-09	2.5179e-09	0.00333	1	0
TRRAP	8295	broad.mit.edu	37	7	98564667	98564667	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr7:98564667C>T	uc003upp.2	+	49	7368	c.7159C>T	c.(7159-7161)CCT>TCT	p.P2387S	TRRAP_uc011kis.1_Missense_Mutation_p.P2369S|TRRAP_uc003upr.2_Missense_Mutation_p.P2086S	NM_003496	NP_003487	Q9Y4A5	TRRAP_HUMAN	transformation/transcription domain-associated	2387	Interaction with TP53.				histone deubiquitination|histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|PCAF complex|STAGA complex|transcription factor TFTC complex	phosphotransferase activity, alcohol group as acceptor|protein binding|transcription cofactor activity			ovary(9)|large_intestine(8)|central_nervous_system(6)|skin(6)|stomach(5)|upper_aerodigestive_tract(1)|lung(1)|liver(1)	37	all_cancers(62;6.96e-09)|all_epithelial(64;4.86e-09)|Lung NSC(181;0.01)|all_lung(186;0.016)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)			CATACAGACACCTACACTCCG	0.358			NA											11	39					0	0	0.001855	0	0
TRRAP	8295	broad.mit.edu	37	7	98591355	98591355	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr7:98591355G>A	uc003upp.2	+	65	10209	c.10000G>A	c.(10000-10002)GAA>AAA	p.E3334K	TRRAP_uc011kis.1_Missense_Mutation_p.E3305K|TRRAP_uc003upr.2_Missense_Mutation_p.E3040K	NM_003496	NP_003487	Q9Y4A5	TRRAP_HUMAN	transformation/transcription domain-associated	3334					histone deubiquitination|histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|PCAF complex|STAGA complex|transcription factor TFTC complex	phosphotransferase activity, alcohol group as acceptor|protein binding|transcription cofactor activity			ovary(9)|large_intestine(8)|central_nervous_system(6)|skin(6)|stomach(5)|upper_aerodigestive_tract(1)|lung(1)|liver(1)	37	all_cancers(62;6.96e-09)|all_epithelial(64;4.86e-09)|Lung NSC(181;0.01)|all_lung(186;0.016)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)			AAATTGGCATGAAGAGGTATT	0.522			NA											11	26					0	0	0.001855	0	0
SMURF1	57154	broad.mit.edu	37	7	98633176	98633176	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr7:98633176G>C	uc003upu.1	-	17	2371	c.2051C>G	c.(2050-2052)TCC>TGC	p.S684C	SMURF1_uc003upv.1_Missense_Mutation_p.S658C|SMURF1_uc003upt.2_Missense_Mutation_p.S658C|TRRAP_uc003ups.2_RNA	NM_020429	NP_065162	Q9HCE7	SMUF1_HUMAN	Smad ubiquitination regulatory factor 1 isoform	684	HECT.				BMP signaling pathway|cell differentiation|ectoderm development|negative regulation of BMP signaling pathway|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of protein ubiquitination|proteasomal ubiquitin-dependent protein catabolic process|protein export from nucleus|protein localization at cell surface|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|receptor catabolic process|transforming growth factor beta receptor signaling pathway|ubiquitin-dependent SMAD protein catabolic process	cytosol|plasma membrane	activin binding|I-SMAD binding|R-SMAD binding|ubiquitin-protein ligase activity			skin(2)|ovary(1)|lung(1)	4	all_cancers(62;1.05e-08)|all_epithelial(64;4.34e-09)|Lung NSC(181;0.00902)|all_lung(186;0.0145)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)|Lung(104;0.224)			GACTCGCGTGGACCCAGTCAC	0.597			NA											22	36					0	0	0.004656	0	0
CPSF4	10898	broad.mit.edu	37	7	99047933	99047933	+	Silent	SNP	C	C	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr7:99047933C>T	uc003uqj.2	+	4	485	c.342C>T	c.(340-342)CAC>CAT	p.H114H	PTCD1_uc011kiw.1_Intron|CPSF4_uc003uqi.2_Silent_p.H114H|CPSF4_uc003uqk.2_Silent_p.H114H|CPSF4_uc011kix.1_Silent_p.H61H	NM_006693	NP_006684	O95639	CPSF4_HUMAN	cleavage and polyadenylation specific factor 4,	114	C3H1-type 3.				modification by virus of host mRNA processing|mRNA processing|viral infectious cycle	mRNA cleavage and polyadenylation specificity factor complex	RNA binding|zinc ion binding			central_nervous_system(1)	1	all_cancers(62;2.54e-08)|all_epithelial(64;2.55e-09)|Lung NSC(181;0.0053)|all_lung(186;0.00895)|Esophageal squamous(72;0.0166)					CCTTCCTGCACATCGACCCCG	0.617			NA											15	34					0	0	0.007413	0	0
MCM7	4176	broad.mit.edu	37	7	99695832	99695832	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr7:99695832C>T	uc003usw.1	-	7	1312	c.802G>A	c.(802-804)GGA>AGA	p.G268R	MCM7_uc003usv.1_Missense_Mutation_p.G92R|MCM7_uc003usx.1_Missense_Mutation_p.G92R	NM_005916	NP_005907	P33993	MCM7_HUMAN	minichromosome maintenance complex component 7	268					cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|regulation of phosphorylation|response to DNA damage stimulus|S phase of mitotic cell cycle	chromatin|MCM complex	ATP binding|protein binding				0	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)				Atorvastatin(DB01076)	ACGTGGTCTCCAGGCTGGGCA	0.527			NA											9	30					0	0	0.006214	0	0
C7orf52	375607	broad.mit.edu	37	7	100817860	100817860	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr7:100817860G>T	uc003uxy.1	-	2	468	c.229C>A	c.(229-231)CTG>ATG	p.L77M	C7orf52_uc003uxz.1_Missense_Mutation_p.L77M|C7orf52_uc003uya.1_Missense_Mutation_p.L77M|C7orf52_uc003uyb.1_Missense_Mutation_p.L77M	NM_198571	NP_940973	Q8N8M0	CG052_HUMAN	hypothetical protein LOC375607	77	N-acetyltransferase.						N-acetyltransferase activity			ovary(1)	1	Lung NSC(181;0.168)|all_lung(186;0.215)					AGGTAGTCCAGGCCGCCGTAG	0.687			NA											16	41					5.3912e-06	6.42881e-06	0.006122	1	0
RELN	5649	broad.mit.edu	37	7	103131117	103131117	+	Silent	SNP	A	A	G			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr7:103131117A>G	uc003vca.2	-	59	9763	c.9603T>C	c.(9601-9603)TCT>TCC	p.S3201S	RELN_uc010liz.2_Silent_p.S3201S	NM_005045	NP_005036	P78509	RELN_HUMAN	reelin isoform a	3201					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			ovary(8)|upper_aerodigestive_tract(5)|large_intestine(2)|central_nervous_system(2)|skin(1)|pancreas(1)	19				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		CAACCTACCTAGAGGAGACAT	0.468	NSCLC(146;835 1944 15585 22231 52158)		NA											35	71					0	0	0.00874	0	0
RELN	5649	broad.mit.edu	37	7	103243856	103243856	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr7:103243856C>G	uc003vca.2	-	24	3388	c.3228G>C	c.(3226-3228)CAG>CAC	p.Q1076H	RELN_uc010liz.2_Missense_Mutation_p.Q1076H	NM_005045	NP_005036	P78509	RELN_HUMAN	reelin isoform a	1076					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			ovary(8)|upper_aerodigestive_tract(5)|large_intestine(2)|central_nervous_system(2)|skin(1)|pancreas(1)	19				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		CCCAGCCATTCTGGTTCTCAA	0.493	NSCLC(146;835 1944 15585 22231 52158)		NA											36	82					0	0	0.004878	0	0
GPR22	2845	broad.mit.edu	37	7	107114493	107114493	+	Translation_Start_Site	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr7:107114493C>A	uc003vef.2	+	3	1334	c.-12C>A	c.(-14--10)AACTG>AAATG		COG5_uc003vec.2_Intron|COG5_uc003ved.2_Intron|COG5_uc003vee.2_Intron	NM_005295	NP_005286	Q99680	GPR22_HUMAN	G protein-coupled receptor 22							integral to plasma membrane	G-protein coupled receptor activity			ovary(2)	2						AAAAAACCAACTGCTCCAAAA	0.318			NA											8	19					0.00307968	0.00328514	0.00308	1	0
GPR22	2845	broad.mit.edu	37	7	107115596	107115596	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr7:107115596C>A	uc003vef.2	+	3	2437	c.1091C>A	c.(1090-1092)CCT>CAT	p.P364H	COG5_uc003vec.2_Intron|COG5_uc003ved.2_Intron|COG5_uc003vee.2_Intron	NM_005295	NP_005286	Q99680	GPR22_HUMAN	G protein-coupled receptor 22	364	Helical; Name=7; (Potential).					integral to plasma membrane	G-protein coupled receptor activity			ovary(2)	2						ATATTTCACCCTCTATTATAT	0.318			NA											13	39					0.000308642	0.000341227	0.003163	1	0
EIF3IP1	442720	broad.mit.edu	37	7	109599700	109599700	+	Missense_Mutation	SNP	T	T	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr7:109599700T>A	uc003vfp.1	-	1	571	c.398A>T	c.(397-399)AAT>ATT	p.N133I		NR_003024				Homo sapiens eukaryotic translation initiation factor 3, subunit I pseudogene 1 (EIF3IP1), non-coding RNA.												0						CTCCTTAATATTCACCAACAC	0.488			NA											7	41					0	0	0.004482	0	0
TMEM168	64418	broad.mit.edu	37	7	112423920	112423920	+	Missense_Mutation	SNP	T	T	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr7:112423920T>A	uc003vgn.2	-	2	1353	c.961A>T	c.(961-963)ACC>TCC	p.T321S	TMEM168_uc010lju.2_Missense_Mutation_p.T321S|TMEM168_uc011kmr.1_Intron	NM_022484	NP_071929	Q9H0V1	TM168_HUMAN	transmembrane protein 168	321						integral to membrane|transport vesicle				ovary(1)|central_nervous_system(1)	2						TTTAATTTGGTATGGAATCCC	0.348			NA											33	81					0	0	0.003755	0	0
GPR85	54329	broad.mit.edu	37	7	112723809	112723809	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr7:112723809G>T	uc010ljv.2	-	2	1485	c.968C>A	c.(967-969)GCT>GAT	p.A323D	GPR85_uc003vgp.1_Missense_Mutation_p.A323D|GPR85_uc003vgq.2_Missense_Mutation_p.A323D|GPR85_uc010ljw.1_Missense_Mutation_p.A323D	NM_001146266	NP_001139738	P60893	GPR85_HUMAN	G protein-coupled receptor 85	323	Helical; Name=7; (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(1)|central_nervous_system(1)	2						CCAGACAGCAGCTGTTAGAAA	0.483			NA											19	28					1.00905e-13	1.51408e-13	0.008871	1	0
CAPZA2	830	broad.mit.edu	37	7	116552135	116552136	+	Missense_Mutation	DNP	GA	GA	TT			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	GA	GA	-	-	GA	GA	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr7:116552135_116552136GA>TT	uc003vil.2	+	8	701_702	c.598_599GA>TT	c.(598-600)GAA>TTA	p.E200L	CAPZA2_uc011knk.1_RNA	NM_006136	NP_006127	P47755	CAZA2_HUMAN	capping protein (actin filament) muscle Z-line,	200					actin cytoskeleton organization|actin filament capping|blood coagulation|cellular component movement|innate immune response|protein complex assembly	cytosol|extracellular region|F-actin capping protein complex	actin binding				0	all_cancers(3;8.53e-08)|all_epithelial(6;7.79e-08)|Lung NSC(10;0.00108)|all_lung(10;0.00125)		GBM - Glioblastoma multiforme(2;5.01e-06)|STAD - Stomach adenocarcinoma(10;0.000512)|all cancers(2;0.00326)			TCATTATTATGAAGATGGTAAT	0.218			NA											25	58					0	0	0.004672	0	0
CFTR	1080	broad.mit.edu	37	7	117170968	117170968	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr7:117170968G>T	uc003vjd.2	+	4	421	c.289G>T	c.(289-291)GTA>TTA	p.V97L	CFTR_uc011knq.1_5'UTR	NM_000492	NP_000483	P13569	CFTR_HUMAN	cystic fibrosis transmembrane conductance	97	Helical; Name=1; (Potential).|ABC transmembrane type-1 1.				respiratory gaseous exchange	apical plasma membrane|basolateral plasma membrane|chloride channel complex|early endosome membrane	ATP binding|ATP-binding and phosphorylation-dependent chloride channel activity|channel-conductance-controlling ATPase activity|chloride channel regulator activity|enzyme binding|PDZ domain binding			central_nervous_system(2)|skin(2)|ovary(1)	5	Lung NSC(10;0.00148)|all_lung(10;0.00171)		STAD - Stomach adenocarcinoma(10;0.000534)		Bumetanide(DB00887)|Glibenclamide(DB01016)	CACCAAAGCAGTACAGCCTCT	0.388			NA							Cystic_Fibrosis				10	22					0.000673444	0.000735791	0.008291	1	0
C7orf58	79974	broad.mit.edu	37	7	120655843	120655843	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr7:120655843C>A	uc003vjq.3	+	3	821	c.374C>A	c.(373-375)ACG>AAG	p.T125K	C7orf58_uc003vjr.1_Missense_Mutation_p.T125K|C7orf58_uc003vjs.3_Missense_Mutation_p.T125K	NM_024913	NP_079189	A4D0V7	CG058_HUMAN	hypothetical protein LOC79974 isoform 1	125						endoplasmic reticulum				ovary(4)|large_intestine(2)|skin(2)|pancreas(1)	9	all_neural(327;0.117)					CATGGCTATACGGTTGTCATC	0.498			NA											10	24					0.000978159	0.00106403	0.000978	1	0
PTPRZ1	5803	broad.mit.edu	37	7	121652129	121652129	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr7:121652129C>A	uc003vjy.2	+	12	3424	c.3029C>A	c.(3028-3030)ACA>AAA	p.T1010K	PTPRZ1_uc003vjz.2_Intron|PTPRZ1_uc011knt.1_Intron	NM_002851	NP_002842	P23471	PTPRZ_HUMAN	protein tyrosine phosphatase, receptor-type,	1010	Extracellular (Potential).				central nervous system development	integral to plasma membrane	protein binding|protein tyrosine/threonine phosphatase activity|transmembrane receptor protein tyrosine phosphatase activity			ovary(3)|large_intestine(2)|lung(2)|central_nervous_system(1)|kidney(1)	9						TTACCTGACACAGATGGGCTG	0.428			NA											14	67					9.31168e-06	1.10067e-05	0.001855	1	0
IQUB	154865	broad.mit.edu	37	7	123092812	123092812	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr7:123092812C>A	uc003vkn.2	-	13	2938	c.2361G>T	c.(2359-2361)CAG>CAT	p.Q787H	IQUB_uc011kny.1_Missense_Mutation_p.Q120H|IQUB_uc003vko.2_Missense_Mutation_p.Q787H|IQUB_uc010lkt.2_RNA	NM_178827	NP_849149	Q8NA54	IQUB_HUMAN	IQ motif and ubiquitin domain containing	787										ovary(3)|large_intestine(1)	4						GAGGAGGCCTCTGGGATTCTA	0.408			NA											14	24					3.27435e-08	4.26728e-08	0.00245	1	0
CPA4	51200	broad.mit.edu	37	7	129938612	129938612	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr7:129938612G>A	uc003vpr.2	+	2	142	c.95G>A	c.(94-96)AGA>AAA	p.R32K	CPA4_uc011kpd.1_Missense_Mutation_p.R32K|CPA4_uc011kpe.1_Intron	NM_016352	NP_057436	Q9UI42	CBPA4_HUMAN	carboxypeptidase A4 preproprotein	32					histone acetylation|proteolysis	extracellular region	metallocarboxypeptidase activity|zinc ion binding			ovary(1)	1	Melanoma(18;0.0435)					ATTAATGTCAGAAATGGAGAC	0.408			NA											11	30					0	0	0.00245	0	0
LRGUK	136332	broad.mit.edu	37	7	133868525	133868525	+	Silent	SNP	A	A	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr7:133868525A>T	uc003vrm.1	+	11	1270	c.1254A>T	c.(1252-1254)ATA>ATT	p.I418I		NM_144648	NP_653249	Q96M69	LRGUK_HUMAN	leucine-rich repeats and guanylate kinase domain	418	Guanylate kinase-like.						ATP binding|kinase activity			lung(2)|skin(2)|kidney(1)	5						CCATGCTGATACTAGCTGGTC	0.488			NA											45	113					0	0	0.00361	0	0
CHRM2	1129	broad.mit.edu	37	7	136700111	136700111	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr7:136700111G>T	uc003vtf.1	+	4	1122	c.499G>T	c.(499-501)GGG>TGG	p.G167W	CHRM2_uc003vtg.1_Missense_Mutation_p.G167W|CHRM2_uc003vtj.1_Missense_Mutation_p.G167W|CHRM2_uc003vtk.1_Missense_Mutation_p.G167W|CHRM2_uc003vtl.1_Missense_Mutation_p.G167W|CHRM2_uc003vtm.1_Missense_Mutation_p.G167W|CHRM2_uc003vti.1_Missense_Mutation_p.G167W|CHRM2_uc003vto.1_Missense_Mutation_p.G167W|CHRM2_uc003vtn.1_Missense_Mutation_p.G167W|uc003vtp.1_Intron	NM_001006630	NP_001006631	P08172	ACM2_HUMAN	cholinergic receptor, muscarinic 2	167	Extracellular (By similarity).				activation of phospholipase C activity by muscarinic acetylcholine receptor signaling pathway|G-protein signaling, coupled to cAMP nucleotide second messenger|nervous system development|regulation of heart contraction|response to virus	cell junction|integral to plasma membrane|postsynaptic membrane	muscarinic acetylcholine receptor activity|protein binding			ovary(4)|central_nervous_system(1)	5					Anisotropine Methylbromide(DB00517)|Atropine(DB00572)|Benzquinamide(DB00767)|Carbachol(DB00411)|Cryptenamine(DB00785)|Cyclizine(DB01176)|Desipramine(DB01151)|Diphenidol(DB01231)|Doxacurium(DB01334)|Doxacurium chloride(DB01135)|Flavoxate(DB01148)|Gallamine Triethiodide(DB00483)|Homatropine Methylbromide(DB00725)|Hyoscyamine(DB00424)|Ipratropium(DB00332)|Methotrimeprazine(DB01403)|Metixene(DB00340)|Metocurine(DB01336)|Mivacurium(DB01226)|Olanzapine(DB00334)|Oxybutynin(DB01062)|Oxyphencyclimine(DB00383)|Pilocarpine(DB01085)|Procyclidine(DB00387)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Rocuronium(DB00728)|Thiethylperazine(DB00372)|Tolterodine(DB01036)|Tridihexethyl(DB00505)|Triflupromazine(DB00508)	GTTCATTGTAGGGGTGAGAAC	0.498			NA											43	97					3.68337e-26	6.45893e-26	0.00361	1	0
CHRM2	1129	broad.mit.edu	37	7	136700860	136700860	+	Nonsense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr7:136700860C>A	uc003vtf.1	+	4	1871	c.1248C>A	c.(1246-1248)TGC>TGA	p.C416*	CHRM2_uc003vtg.1_Nonsense_Mutation_p.C416*|CHRM2_uc003vtj.1_Nonsense_Mutation_p.C416*|CHRM2_uc003vtk.1_Nonsense_Mutation_p.C416*|CHRM2_uc003vtl.1_Nonsense_Mutation_p.C416*|CHRM2_uc003vtm.1_Nonsense_Mutation_p.C416*|CHRM2_uc003vti.1_Nonsense_Mutation_p.C416*|CHRM2_uc003vto.1_Nonsense_Mutation_p.C416*|CHRM2_uc003vtn.1_Nonsense_Mutation_p.C416*|uc003vtp.1_Intron	NM_001006630	NP_001006631	P08172	ACM2_HUMAN	cholinergic receptor, muscarinic 2	416	Extracellular (By similarity).				activation of phospholipase C activity by muscarinic acetylcholine receptor signaling pathway|G-protein signaling, coupled to cAMP nucleotide second messenger|nervous system development|regulation of heart contraction|response to virus	cell junction|integral to plasma membrane|postsynaptic membrane	muscarinic acetylcholine receptor activity|protein binding			ovary(4)|central_nervous_system(1)	5					Anisotropine Methylbromide(DB00517)|Atropine(DB00572)|Benzquinamide(DB00767)|Carbachol(DB00411)|Cryptenamine(DB00785)|Cyclizine(DB01176)|Desipramine(DB01151)|Diphenidol(DB01231)|Doxacurium(DB01334)|Doxacurium chloride(DB01135)|Flavoxate(DB01148)|Gallamine Triethiodide(DB00483)|Homatropine Methylbromide(DB00725)|Hyoscyamine(DB00424)|Ipratropium(DB00332)|Methotrimeprazine(DB01403)|Metixene(DB00340)|Metocurine(DB01336)|Mivacurium(DB01226)|Olanzapine(DB00334)|Oxybutynin(DB01062)|Oxyphencyclimine(DB00383)|Pilocarpine(DB01085)|Procyclidine(DB00387)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Rocuronium(DB00728)|Thiethylperazine(DB00372)|Tolterodine(DB01036)|Tridihexethyl(DB00505)|Triflupromazine(DB00508)	GTGCACCTTGCATCCCCAACA	0.458			NA											55	109					2.36135e-34	4.2665e-34	0.00361	1	0
DGKI	9162	broad.mit.edu	37	7	137150701	137150701	+	Silent	SNP	C	C	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr7:137150701C>T	uc003vtt.2	-	27	2590	c.2589G>A	c.(2587-2589)GCG>GCA	p.A863A	DGKI_uc003vtu.2_Silent_p.A573A	NM_004717	NP_004708	O75912	DGKI_HUMAN	diacylglycerol kinase, iota	863					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	nucleus|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			ovary(1)|kidney(1)|skin(1)	3						GAGGTGTCCCCGCCGGCTGTG	0.532			NA											13	45					0	0	0.00245	0	0
TRIM24	8805	broad.mit.edu	37	7	138264263	138264263	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr7:138264263G>C	uc003vuc.2	+	15	2786	c.2571G>C	c.(2569-2571)TTG>TTC	p.L857F	TRIM24_uc003vub.2_Missense_Mutation_p.L823F	NM_015905	NP_056989	O15164	TIF1A_HUMAN	transcriptional intermediary factor 1 alpha	857	PHD-type.				cellular response to estrogen stimulus|protein catabolic process|regulation of apoptosis|regulation of protein stability|transcription from RNA polymerase II promoter	cytoplasm	chromatin binding|estrogen response element binding|histone acetyl-lysine binding|p53 binding|transcription coactivator activity|ubiquitin-protein ligase activity|zinc ion binding			central_nervous_system(3)|ovary(2)|stomach(1)|breast(1)|skin(1)	8						TGCCCACATTGACAAATTTTC	0.388	Pancreas(179;936 2074 16128 47811 50326)|Colon(136;168 1735 9344 12243 52014)		NA											17	37					0	0	0.001882	0	0
SVOPL	136306	broad.mit.edu	37	7	138305866	138305866	+	Silent	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr7:138305866C>A	uc011kqh.1	-	13	1278	c.1278G>T	c.(1276-1278)ACG>ACT	p.T426T	SVOPL_uc003vue.2_Silent_p.T274T	NM_001139456	NP_001132928	Q8N434	SVOPL_HUMAN	SVOP-like isoform 1	426						integral to membrane	transmembrane transporter activity				0						AAGCGCGCATCGTGGTGGGGT	0.602			NA											8	40					2.80697e-09	3.77735e-09	0.000978	1	0
ZC3HAV1L	92092	broad.mit.edu	37	7	138713461	138713461	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr7:138713461C>T	uc003vum.1	-	3	759	c.747G>A	c.(745-747)ATG>ATA	p.M249I		NM_080660	NP_542391	Q96H79	ZCCHL_HUMAN	zinc finger CCCH-type, antiviral 1-like	249											0						TATTTTCAAGCATCTTGTGCA	0.398			NA											17	86					0	0	0.001882	0	0
TBXAS1	6916	broad.mit.edu	37	7	139655362	139655362	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr7:139655362G>A	uc011kqv.1	+	8	949	c.785G>A	c.(784-786)CGT>CAT	p.R262H	TBXAS1_uc003vvh.2_Missense_Mutation_p.R216H|TBXAS1_uc010lne.2_Missense_Mutation_p.R148H|TBXAS1_uc011kqu.1_Missense_Mutation_p.R167H|TBXAS1_uc003vvi.2_Missense_Mutation_p.R216H|TBXAS1_uc003vvj.2_Missense_Mutation_p.R216H|TBXAS1_uc011kqw.1_Missense_Mutation_p.R196H	NM_001130966	NP_001124438	P24557	THAS_HUMAN	thromboxane A synthase 1, platelet isoform	215	Cytoplasmic (Potential).				hormone biosynthetic process|prostaglandin biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum lumen|endoplasmic reticulum membrane|integral to membrane	electron carrier activity|heme binding|monooxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen|thromboxane-A synthase activity			ovary(2)|breast(1)	3	Melanoma(164;0.0142)					CACTGCAAGCGTTTCTTCGAA	0.577			NA											12	49					0	0	0.003163	0	0
DENND2A	27147	broad.mit.edu	37	7	140221738	140221738	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr7:140221738C>T	uc010lnj.2	-	16	2973	c.2828G>A	c.(2827-2829)CGC>CAC	p.R943H	DENND2A_uc011kre.1_RNA|DENND2A_uc010lnk.2_Missense_Mutation_p.R943H|DENND2A_uc003vvw.2_Missense_Mutation_p.R943H	NM_015689	NP_056504	Q9ULE3	DEN2A_HUMAN	DENN/MADD domain containing 2A	943	dDENN.									ovary(3)|breast(1)	4	Melanoma(164;0.00956)					CAGGAAGTGGCGGAGGCTCTT	0.602			NA											6	33					0	0	0.001984	0	0
DENND2A	27147	broad.mit.edu	37	7	140285455	140285455	+	Silent	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr7:140285455C>A	uc010lnj.2	-	3	1324	c.1179G>T	c.(1177-1179)CTG>CTT	p.L393L	DENND2A_uc011kre.1_RNA|DENND2A_uc010lnk.2_Silent_p.L393L|DENND2A_uc003vvw.2_Silent_p.L393L|DENND2A_uc003vvx.2_Silent_p.L393L	NM_015689	NP_056504	Q9ULE3	DEN2A_HUMAN	DENN/MADD domain containing 2A	393										ovary(3)|breast(1)	4	Melanoma(164;0.00956)					ACTTCTTTCCCAGGCAGCGAC	0.522			NA											35	103					9.73076e-26	1.69632e-25	0.006999	1	0
OR9A4	130075	broad.mit.edu	37	7	141619410	141619410	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr7:141619410C>A	uc003vwu.1	+	1	735	c.735C>A	c.(733-735)TTC>TTA	p.F245L		NM_001001656	NP_001001656	Q8NGU2	OR9A4_HUMAN	olfactory receptor, family 9, subfamily A,	245	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	Melanoma(164;0.0171)					CCTCCCACTTCACCTGTGTTG	0.502			NA											14	41					0.000308642	0.000341227	0.003163	1	0
MGAM	8972	broad.mit.edu	37	7	141719069	141719069	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr7:141719069C>T	uc003vwy.2	+	4	452	c.398C>T	c.(397-399)TCC>TTC	p.S133F		NM_004668	NP_004659	O43451	MGA_HUMAN	maltase-glucoamylase	133	P-type 1.|Lumenal (Potential).				polysaccharide digestion|starch catabolic process	apical plasma membrane|integral to membrane	carbohydrate binding|glucan 1,4-alpha-glucosidase activity|maltose alpha-glucosidase activity			ovary(2)	2	Melanoma(164;0.0272)				Acarbose(DB00284)|Miglitol(DB00491)|Voglibose(DB04878)	TGCTACTATTCCAAGAATCAT	0.512			NA											22	44					0	0	0.00278	0	0
EPHB6	2051	broad.mit.edu	37	7	142561857	142561857	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr7:142561857C>A	uc011kst.1	+	7	1086	c.299C>A	c.(298-300)GCC>GAC	p.A100D	EPHB6_uc011ksu.1_Missense_Mutation_p.A100D|EPHB6_uc003wbs.2_5'UTR|EPHB6_uc003wbt.2_5'UTR|EPHB6_uc003wbu.2_5'UTR	NM_004445	NP_004436	O15197	EPHB6_HUMAN	ephrin receptor EphB6 precursor	100	Extracellular (Potential).					extracellular region|integral to plasma membrane	ATP binding|ephrin receptor activity			lung(8)|large_intestine(4)|central_nervous_system(3)|stomach(1)|skin(1)|ovary(1)|pancreas(1)	19	Melanoma(164;0.059)					CGGCGCGGGGCCCAGAGGGCG	0.647			NA											58	163					1.05635e-38	1.92972e-38	0.00361	1	0
TRPV6	55503	broad.mit.edu	37	7	142574532	142574532	+	Silent	SNP	G	G	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr7:142574532G>A	uc003wbx.1	-	5	762	c.546C>T	c.(544-546)CTC>CTT	p.L182L	TRPV6_uc003wbw.1_5'Flank|TRPV6_uc010lou.1_Silent_p.L53L	NM_018646	NP_061116	Q9H1D0	TRPV6_HUMAN	transient receptor potential cation channel,	182	ANK 4.|Cytoplasmic (Potential).				regulation of calcium ion-dependent exocytosis	integral to plasma membrane	calcium channel activity|calmodulin binding			ovary(2)	2	Melanoma(164;0.059)					CATGCTCAATGAGCAGCCGCA	0.597			NA											44	56					0	0	0.00361	0	0
OR9A2	135924	broad.mit.edu	37	7	142724168	142724168	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr7:142724168C>A	uc003wcc.1	-	1	52	c.52G>T	c.(52-54)GGG>TGG	p.G18W		NM_001001658	NP_001001658	Q8NGT5	OR9A2_HUMAN	olfactory receptor, family 9, subfamily A,	18	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	Melanoma(164;0.059)					CCTTGGGACCCAGGGAAGCCT	0.413			NA											18	29					8.04996e-18	1.30823e-17	0.001882	1	0
FAM115C	285966	broad.mit.edu	37	7	143417194	143417194	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr7:143417194C>A	uc003wdf.2	+	3	1125	c.1042C>A	c.(1042-1044)CAG>AAG	p.Q348K	FAM115C_uc003wdg.2_Missense_Mutation_p.Q67K|FAM115C_uc011ktk.1_Missense_Mutation_p.Q348K|FAM115C_uc003wdh.2_Missense_Mutation_p.Q348K|FAM115C_uc011ktm.1_Missense_Mutation_p.Q348K|uc011ktn.1_Intron|uc011kto.1_Intron|uc011ktp.1_Intron|LOC154761_uc011ktq.1_Intron|LOC154761_uc011ktr.1_Intron|LOC154761_uc011kts.1_Intron|FAM115C_uc011ktt.1_Missense_Mutation_p.Q184K|FAM115C_uc003wdi.1_Missense_Mutation_p.Q67K	NM_001130025	NP_001123497	A6NFQ2	F115C_HUMAN	hypothetical protein LOC285966 isoform A	348											0						TAAGCAGCTGCAGGAGTTTGT	0.632			NA											20	82					1.55795e-14	2.38095e-14	0.001882	1	0
OR6B1	135946	broad.mit.edu	37	7	143701462	143701462	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr7:143701462G>T	uc003wdt.1	+	1	373	c.373G>T	c.(373-375)GCC>TCC	p.A125S		NM_001005281	NP_001005281	O95007	OR6B1_HUMAN	olfactory receptor, family 6, subfamily B,	125	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	Melanoma(164;0.0783)					CCGGTATGTGGCCATCTGTCG	0.537			NA											20	72					1.01871e-10	1.42505e-10	0.008871	1	0
OR2A2	442361	broad.mit.edu	37	7	143807247	143807247	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr7:143807247C>T	uc011ktz.1	+	1	572	c.572C>T	c.(571-573)ACC>ATC	p.T191I		NM_001005480	NP_001005480	Q6IF42	OR2A2_HUMAN	olfactory receptor, family 2, subfamily A,	191	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2	Melanoma(164;0.0783)					TGTGCTGACACCTGGGTTAAC	0.512			NA											54	115					0	0	0.00361	0	0
NOBOX	135935	broad.mit.edu	37	7	144098216	144098216	+	Missense_Mutation	SNP	T	T	C			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr7:144098216T>C	uc011kue.1	-	4	767	c.767A>G	c.(766-768)CAA>CGA	p.Q256R		NM_001080413	NP_001073882	O60393	NOBOX_HUMAN	NOBOX oogenesis homeobox	256					cell differentiation|oogenesis	nucleus	sequence-specific DNA binding			ovary(1)	1	Melanoma(164;0.14)					GTCTCTGTTTTGGTTGCTCTG	0.577			NA											10	17					0	0	0.006214	0	0
CNTNAP2	26047	broad.mit.edu	37	7	147259301	147259301	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr7:147259301G>C	uc003weu.1	+	12	2365	c.1849G>C	c.(1849-1851)GAT>CAT	p.D617H		NM_014141	NP_054860	Q9UHC6	CNTP2_HUMAN	cell recognition molecule Caspr2 precursor	617	Extracellular (Potential).|Fibrinogen C-terminal.				behavior|cell adhesion|clustering of voltage-gated potassium channels|limbic system development|neuron recognition|signal transduction|striatum development|superior temporal gyrus development|thalamus development|transmission of nerve impulse	axolemma|cell body fiber|dendrite|juxtaparanode region of axon|voltage-gated potassium channel complex	receptor binding			ovary(9)|central_nervous_system(1)|pancreas(1)	11	Melanoma(164;0.153)	all_cancers(3;3.51e-10)|all_epithelial(3;1.4e-05)|Myeloproliferative disorder(3;0.00452)|Lung NSC(3;0.0067)|all_lung(3;0.00794)	OV - Ovarian serous cystadenocarcinoma(82;0.0319)			GATAGATCCTGATGGCAGCGG	0.403			NA								HNSCC(39;0.1)			17	47					0	0	0.008871	0	0
ZNF786	136051	broad.mit.edu	37	7	148768605	148768605	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr7:148768605C>A	uc003wfh.2	-	4	1396	c.1259G>T	c.(1258-1260)GGT>GTT	p.G420V	ZNF786_uc011kuk.1_Missense_Mutation_p.G383V|ZNF786_uc003wfi.2_Missense_Mutation_p.G334V	NM_152411	NP_689624	Q8N393	ZN786_HUMAN	zinc finger protein 786	420					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(3)|skin(1)	4	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00463)			TCTCTCCCCACCGTGCGCGTG	0.622			NA											11	24					9.31168e-06	1.10067e-05	0.001855	1	0
KRBA1	84626	broad.mit.edu	37	7	149427646	149427646	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr7:149427646G>T	uc003wfz.2	+	16	2533	c.2134G>T	c.(2134-2136)GGC>TGC	p.G712C	KRBA1_uc010lpj.2_RNA|KRBA1_uc003wga.2_RNA|KRBA1_uc003wgb.2_Missense_Mutation_p.G319C	NM_032534	NP_115923	A5PL33	KRBA1_HUMAN	KRAB A domain containing 1	712	Pro-rich.									ovary(1)|central_nervous_system(1)	2	Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			GTACTGCAGCGGCCTCGGTGC	0.662			NA											7	12					1.12685e-05	1.32356e-05	0.004482	1	0
SSPO	23145	broad.mit.edu	37	7	149477097	149477097	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr7:149477097G>T	uc010lpk.2	+	11	1274	c.1274G>T	c.(1273-1275)GGG>GTG	p.G425V	SSPO_uc010lpl.1_Intron	NM_198455	NP_940857	A2VEC9	SSPO_HUMAN	SCO-spondin precursor	425					cell adhesion	extracellular space	peptidase inhibitor activity				0	Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			TACTGCGCAGGGGCCATGGCA	0.637			NA											3	9					0.004672	0.00493414	0.004672	1	0
GIMAP1	170575	broad.mit.edu	37	7	150417431	150417431	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr7:150417431C>A	uc003whq.2	+	3	426	c.339C>A	c.(337-339)CAC>CAA	p.H113Q	GIMAP1_uc003whp.2_Missense_Mutation_p.H121Q	NM_130759	NP_570115	Q8WWP7	GIMA1_HUMAN	GTPase, IMAP family member 1	113	Cytoplasmic (Potential).					endoplasmic reticulum membrane|integral to membrane	GTP binding			ovary(1)|breast(1)|central_nervous_system(1)	3			OV - Ovarian serous cystadenocarcinoma(82;0.0145)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		CCGGACCCCACGCGCTGCTCC	0.622			NA											12	32					3.07112e-06	3.69777e-06	0.000978	1	0
NOS3	4846	broad.mit.edu	37	7	150707685	150707685	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr7:150707685G>T	uc003wif.2	+	22	2982	c.2686G>T	c.(2686-2688)GAT>TAT	p.D896Y	NOS3_uc011kuy.1_Missense_Mutation_p.D690Y	NM_000603	NP_000594	P29474	NOS3_HUMAN	nitric oxide synthase 3 isoform 1	896	FAD-binding FR-type.				anti-apoptosis|arginine catabolic process|blood vessel remodeling|endothelial cell migration|mitochondrion organization|negative regulation of muscle hyperplasia|negative regulation of platelet activation|nitric oxide biosynthetic process|platelet activation|positive regulation of angiogenesis|positive regulation of guanylate cyclase activity|positive regulation of vasodilation|regulation of blood vessel size|regulation of nitric-oxide synthase activity|regulation of systemic arterial blood pressure by endothelin|response to fluid shear stress|response to heat|smooth muscle hyperplasia	caveola|cytoskeleton|cytosol|Golgi membrane	actin monomer binding|arginine binding|cadmium ion binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|tetrahydrobiopterin binding			central_nervous_system(5)|large_intestine(2)|skin(1)	8	all_neural(206;0.219)		OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)	L-Arginine(DB00125)|L-Citrulline(DB00155)|Rosuvastatin(DB01098)|Tetrahydrobiopterin(DB00360)	GCCCCGCCAGGATCCCCGACG	0.647			NA											6	11					0.00198382	0.00213454	0.001984	1	0
MLL3	58508	broad.mit.edu	37	7	151860040	151860040	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr7:151860040C>A	uc003wla.2	-	43	10841	c.10622G>T	c.(10621-10623)GGG>GTG	p.G3541V	MLL3_uc003wkz.2_Missense_Mutation_p.G2602V|MLL3_uc003wky.2_Missense_Mutation_p.G1050V	NM_170606	NP_733751	Q8NEZ4	MLL3_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 3	3541					intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			large_intestine(27)|pancreas(13)|ovary(9)|central_nervous_system(8)|breast(3)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	63	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)		GAAGCTGGTCCCAGAAAGATT	0.498	Colon(68;14 1149 1884 27689 34759)		NA	N		medulloblastoma								19	37					1.96292e-10	2.73046e-10	0.010504	1	0
XRCC2	7516	broad.mit.edu	37	7	152345743	152345743	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr7:152345743C>G	uc003wld.2	-	3	913	c.827G>C	c.(826-828)GGG>GCG	p.G276A		NM_005431	NP_005422	O43543	XRCC2_HUMAN	X-ray repair cross complementing protein 2	276					meiosis	nucleus	ATP binding|DNA binding|DNA-dependent ATPase activity			breast(1)|liver(1)	2		all_hematologic(28;0.0592)|Prostate(32;0.081)	OV - Ovarian serous cystadenocarcinoma(82;0.0423)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0429)		AAATTCAACCCCACTTTCTCC	0.239			NA						Homologous_recombination					5	23					0	0	0.000602	0	0
HTR5A	3361	broad.mit.edu	37	7	154863225	154863225	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr7:154863225G>T	uc003wlu.1	+	1	680	c.616G>T	c.(616-618)GTA>TTA	p.V206L	uc011kvt.1_5'UTR|uc003wlt.2_5'UTR	NM_024012	NP_076917	P47898	5HT5A_HUMAN	5-hydroxytryptamine receptor 5A	206	Helical; Name=5; (By similarity).					integral to plasma membrane	serotonin receptor activity			ovary(2)|large_intestine(1)	3	all_neural(206;0.119)	all_hematologic(28;0.0592)	OV - Ovarian serous cystadenocarcinoma(82;0.0238)	UCEC - Uterine corpus endometrioid carcinoma (81;0.171)		GTTCTCCACCGTAGGCGCCTT	0.607			NA											11	30					9.04627e-18	1.46694e-17	0.001855	1	0
ESYT2	57488	broad.mit.edu	37	7	158534284	158534284	+	Missense_Mutation	SNP	T	T	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr7:158534284T>A	uc003wob.1	-	17	2245	c.2179A>T	c.(2179-2181)AGC>TGC	p.S727C	ESYT2_uc003woc.1_Missense_Mutation_p.S551C|ESYT2_uc003wny.1_RNA|ESYT2_uc003wnz.1_Missense_Mutation_p.S166C|ESYT2_uc003woa.1_Missense_Mutation_p.S304C	NM_020728	NP_065779	A0FGR8	ESYT2_HUMAN	family with sequence similarity 62 (C2 domain	755						integral to membrane|plasma membrane				central_nervous_system(2)|kidney(1)	3						GAGGCGATGCTGGGGGTCGGC	0.647			NA											20	33					0	0	0.00278	0	0
DLGAP2	9228	broad.mit.edu	37	8	1496869	1496869	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr8:1496869C>A	uc003wpl.2	+	2	107	c.10C>A	c.(10-12)CTT>ATT	p.L4I	DLGAP2_uc003wpm.2_Missense_Mutation_p.L4I	NM_004745	NP_004736	Q9P1A6	DLGP2_HUMAN	discs large-associated protein 2	83					neuron-neuron synaptic transmission	cell junction|neurofilament|postsynaptic density|postsynaptic membrane	protein binding				0		Ovarian(12;0.0271)|Hepatocellular(245;0.0838)|Colorectal(14;0.0846)		BRCA - Breast invasive adenocarcinoma(11;0.000169)|READ - Rectum adenocarcinoma(644;0.171)		CATGAAGGGCCTTTCCGGAAG	0.677			NA											5	12					5.18039e-06	6.18734e-06	0.00308	1	0
DLGAP2	9228	broad.mit.edu	37	8	1497625	1497625	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr8:1497625G>A	uc003wpl.2	+	2	863	c.766G>A	c.(766-768)GGG>AGG	p.G256R	DLGAP2_uc003wpm.2_Missense_Mutation_p.G256R	NM_004745	NP_004736	Q9P1A6	DLGP2_HUMAN	discs large-associated protein 2	335					neuron-neuron synaptic transmission	cell junction|neurofilament|postsynaptic density|postsynaptic membrane	protein binding				0		Ovarian(12;0.0271)|Hepatocellular(245;0.0838)|Colorectal(14;0.0846)		BRCA - Breast invasive adenocarcinoma(11;0.000169)|READ - Rectum adenocarcinoma(644;0.171)		GAGCCCCTTCGGGGACCTGTC	0.672			NA											13	62					0	0	0.007413	0	0
CSMD1	64478	broad.mit.edu	37	8	2944787	2944787	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr8:2944787G>T	uc011kwk.1	-	49	7699	c.7309C>A	c.(7309-7311)CAC>AAC	p.H2437N	CSMD1_uc011kwj.1_Missense_Mutation_p.H1766N|CSMD1_uc010lrg.2_Missense_Mutation_p.H505N	NM_033225	NP_150094	Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1 precursor	2437	Sushi 14.|Extracellular (Potential).					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		TTCAGGGGGTGGGTCAAACTG	0.488			NA											19	61					1.87028e-06	2.28898e-06	0.001882	1	0
SPAG11B	10407	broad.mit.edu	37	8	7308656	7308656	+	Nonsense_Mutation	SNP	T	T	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr8:7308656T>A	uc003wrk.2	-	3	447	c.280A>T	c.(280-282)AGA>TGA	p.R94*	SPAG11B_uc003wrg.1_Intron|SPAG11B_uc003wrh.1_Intron|SPAG11B_uc003wri.2_Nonsense_Mutation_p.R41*|SPAG11B_uc003wrj.2_Intron|SPAG11B_uc003wrl.2_Intron	NM_016512	NP_057596	Q08648	SG11B_HUMAN	sperm associated antigen 11B isoform A	94					spermatogenesis	extracellular region					0				COAD - Colon adenocarcinoma(149;0.0162)|READ - Rectum adenocarcinoma(644;0.236)		CTGGCCCATCTAGGCCCTAAA	0.443			NA											8	60					0	0	0.008291	0	0
SGK223	157285	broad.mit.edu	37	8	8234233	8234233	+	Silent	SNP	C	C	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr8:8234233C>T	uc003wsh.3	-	2	1686	c.1686G>A	c.(1684-1686)GGG>GGA	p.G562G		NM_001080826	NP_001074295	Q86YV5	SG223_HUMAN	pragmin	562							ATP binding|non-membrane spanning protein tyrosine kinase activity				0						ACACTGGGGGCCCTCCAGCAG	0.652	GBM(34;731 755 10259 33573 33867)		NA											11	25					0	0	0.001368	0	0
RP1L1	94137	broad.mit.edu	37	8	10466404	10466404	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr8:10466404C>A	uc003wtc.2	-	4	5433	c.5204G>T	c.(5203-5205)AGC>ATC	p.S1735I		NM_178857	NP_849188	Q8IWN7	RP1L1_HUMAN	retinitis pigmentosa 1-like 1	1735					intracellular signal transduction					ovary(4)|breast(3)|central_nervous_system(1)	8				COAD - Colon adenocarcinoma(149;0.0811)		AGGCCCCTGGCTCAGCCCCGG	0.657			NA											34	101					5.71845e-15	8.82089e-15	0.005524	1	0
RP1L1	94137	broad.mit.edu	37	8	10469309	10469310	+	Missense_Mutation	DNP	CC	CC	AA			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr8:10469309_10469310CC>AA	uc003wtc.2	-	4	2527_2528	c.2298_2299GG>TT	c.(2296-2301)GCGGGG>GCTTGG	p.G767W		NM_178857	NP_849188	Q8IWN7	RP1L1_HUMAN	retinitis pigmentosa 1-like 1	767					intracellular signal transduction					ovary(4)|breast(3)|central_nervous_system(1)	8				COAD - Colon adenocarcinoma(149;0.0811)		GTCCTGGACCCCGCGTCCCCTG	0.658			NA											24	48					0	0	0.004672	0	0
C8orf74	203076	broad.mit.edu	37	8	10555264	10555264	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr8:10555264C>A	uc003wtd.1	+	3	426	c.397C>A	c.(397-399)CAG>AAG	p.Q133K	C8orf74_uc003wte.1_RNA	NM_001040032	NP_001035121	Q6P047	CH074_HUMAN	hypothetical protein LOC203076	133											0				COAD - Colon adenocarcinoma(149;0.0811)		GGGCCAGGACCAGCAGGTCGA	0.617			NA											61	180					1.17954e-47	2.18156e-47	0.00361	1	0
SOX7	83595	broad.mit.edu	37	8	10583411	10583411	+	Missense_Mutation	SNP	T	T	C			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr8:10583411T>C	uc003wtf.2	-	2	1083	c.1004A>G	c.(1003-1005)TAT>TGT	p.Y335C	SOX7_uc011kwz.1_Missense_Mutation_p.Y387C	NM_031439	NP_113627	Q9BT81	SOX7_HUMAN	SRY-box 7	335	Sox C-terminal.				endoderm formation|negative regulation of cell proliferation|negative regulation of transcription, DNA-dependent|positive regulation of caspase activity|regulation of canonical Wnt receptor signaling pathway	cytoplasm|nucleus	transcription regulatory region DNA binding			breast(1)	1				COAD - Colon adenocarcinoma(149;0.0732)		AGTGTTCAAATACTGGTCGAA	0.617			NA											10	30					0	0	0.001855	0	0
DOK2	9046	broad.mit.edu	37	8	21768283	21768283	+	Silent	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr8:21768283C>A	uc003wzy.1	-	4	612	c.519G>T	c.(517-519)CGG>CGT	p.R173R	DOK2_uc003wzx.1_Silent_p.R173R|DOK2_uc003wzz.1_Silent_p.R19R|DOK2_uc010lth.1_Silent_p.R19R	NM_003974	NP_003965	O60496	DOK2_HUMAN	docking protein 2	173	IRS-type PTB.				blood coagulation|leukocyte migration	cytosol	identical protein binding|insulin receptor binding				0				Colorectal(74;0.0145)|COAD - Colon adenocarcinoma(73;0.0608)		TCTCCCCAGCCCGGAGGGTAT	0.642			NA											8	17					0.000274275	0.000304364	0.004482	1	0
BMP1	649	broad.mit.edu	37	8	22035416	22035417	+	Missense_Mutation	DNP	GG	GG	CT			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr8:22035416_22035417GG>CT	uc003xbg.2	+	6	1026_1027	c.782_783GG>CT	c.(781-783)GGG>GCT	p.G261A	BMP1_uc011kzb.1_RNA|BMP1_uc003xba.2_Missense_Mutation_p.G261A|BMP1_uc003xbb.2_Missense_Mutation_p.G261A|BMP1_uc003xbe.2_RNA|BMP1_uc003xbc.2_Missense_Mutation_p.G10A|BMP1_uc003xbd.2_RNA|BMP1_uc003xbf.2_Missense_Mutation_p.G10A|BMP1_uc011kzc.1_Missense_Mutation_p.G10A|BMP1_uc003xbh.2_RNA|BMP1_uc003xbi.2_RNA	NM_006129	NP_006120	P13497	BMP1_HUMAN	bone morphogenetic protein 1 isoform 3	261	Metalloprotease.				cartilage condensation|cell differentiation|lipid metabolic process|lipoprotein metabolic process|ossification|positive regulation of cartilage development|proteolysis	extracellular space	calcium ion binding|cytokine activity|growth factor activity|metalloendopeptidase activity|zinc ion binding			ovary(2)|breast(1)	3				Colorectal(74;0.00229)|COAD - Colon adenocarcinoma(73;0.0661)|READ - Rectum adenocarcinoma(644;0.11)		GAGTCCCTGGGGGAGACCTATG	0.609			NA											30	133					0	0	0.004672	0	0
PIWIL2	55124	broad.mit.edu	37	8	22138988	22138988	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr8:22138988G>T	uc003xbn.2	+	4	533	c.385G>T	c.(385-387)GGG>TGG	p.G129W	PIWIL2_uc011kzf.1_Missense_Mutation_p.G129W|PIWIL2_uc010ltv.2_Missense_Mutation_p.G129W	NM_018068	NP_060538	Q8TC59	PIWL2_HUMAN	piwi-like 2	129					DNA methylation involved in gamete generation|gene silencing by RNA|germ-line stem cell maintenance|multicellular organismal development|oogenesis|piRNA metabolic process|positive regulation of translation|RNA 5'-end processing|spermatogenesis	chromatoid body|pi-body	piRNA binding			skin(1)	1				Colorectal(74;0.018)|COAD - Colon adenocarcinoma(73;0.0707)		GTTGGCGGCTGGGGACAGCAA	0.488			NA											11	40					3.07112e-06	3.69777e-06	0.000978	1	0
FBXO16	157574	broad.mit.edu	37	8	28321313	28321313	+	Missense_Mutation	SNP	T	T	C			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr8:28321313T>C	uc003xgu.2	-	4	256	c.158A>G	c.(157-159)CAA>CGA	p.Q53R	ZNF395_uc003xgt.2_5'UTR|FBXO16_uc003xgv.2_Missense_Mutation_p.Q40R|FBXO16_uc003xgw.2_Missense_Mutation_p.Q40R	NM_172366	NP_758954	Q8IX29	FBX16_HUMAN	F-box only protein 16	53										ovary(1)	1		Ovarian(32;2.06e-05)		KIRC - Kidney renal clear cell carcinoma(542;0.121)|Kidney(114;0.144)|Colorectal(74;0.249)		TCTTCTTCTTTGAGAGTCTGT	0.438			NA											12	23					0	0	0.004007	0	0
GSR	2936	broad.mit.edu	37	8	30567405	30567405	+	Silent	SNP	T	T	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr8:30567405T>A	uc003xih.1	-	3	439	c.348A>T	c.(346-348)ACA>ACT	p.T116T		NM_000637	NP_000628	P00390	GSHR_HUMAN	glutathione reductase precursor	116					cell redox homeostasis|nucleobase, nucleoside and nucleotide interconversion	cytosol|mitochondrion	electron carrier activity|glutathione-disulfide reductase activity			ovary(2)|pancreas(2)|central_nervous_system(1)	5				KIRC - Kidney renal clear cell carcinoma(542;0.105)|Kidney(114;0.125)	Carmustine(DB00262)|Glutathione(DB00143)|NADH(DB00157)	AGTGGACAGCTGTGTTCCACA	0.383			NA											6	17					0	0	0.001168	0	0
TEX15	56154	broad.mit.edu	37	8	30705252	30705252	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr8:30705252C>T	uc003xil.2	-	1	1282	c.1282G>A	c.(1282-1284)GAA>AAA	p.E428K		NM_031271	NP_112561	Q9BXT5	TEX15_HUMAN	testis expressed 15	428										ovary(3)|upper_aerodigestive_tract(2)|skin(2)	7				KIRC - Kidney renal clear cell carcinoma(542;0.0918)|Kidney(114;0.111)		GGTTCATTTTCATTTTTCCTA	0.338			NA											15	81					0	0	0.003163	0	0
NRG1	3084	broad.mit.edu	37	8	32617782	32617782	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr8:32617782G>A	uc003xiv.2	+	11	1643	c.1126G>A	c.(1126-1128)GTA>ATA	p.V376I	NRG1_uc011lbf.1_Missense_Mutation_p.V373I|NRG1_uc010lvo.2_Missense_Mutation_p.V373I|NRG1_uc003xiu.2_Missense_Mutation_p.V381I|NRG1_uc003xiw.2_Missense_Mutation_p.V373I|NRG1_uc003xit.2_Missense_Mutation_p.V376I|NRG1_uc010lvr.2_Missense_Mutation_p.V118I|NRG1_uc010lvs.2_Missense_Mutation_p.V118I|NRG1_uc010lvp.2_Missense_Mutation_p.V330I|NRG1_uc010lvq.2_Missense_Mutation_p.V313I|NRG1_uc011lbg.1_Missense_Mutation_p.V222I|NRG1_uc011lbh.1_Missense_Mutation_p.V219I|NRG1_uc003xja.2_Missense_Mutation_p.V187I	NM_013964	NP_039258	Q02297	NRG1_HUMAN	neuregulin 1 isoform HRG-alpha	376	Cytoplasmic (Potential).				activation of transmembrane receptor protein tyrosine kinase activity|anti-apoptosis|cardiac muscle cell differentiation|cell communication|cell proliferation|cellular protein complex disassembly|embryo development|mammary gland development|negative regulation of cardiac muscle cell apoptosis|negative regulation of secretion|negative regulation of transcription, DNA-dependent|nervous system development|neural crest cell development|Notch signaling pathway|positive regulation of cardiac muscle cell proliferation|positive regulation of cell adhesion|positive regulation of cell growth|positive regulation of striated muscle cell differentiation|regulation of protein heterodimerization activity|regulation of protein homodimerization activity|transmembrane receptor protein tyrosine kinase signaling pathway|ventricular cardiac muscle cell differentiation|wound healing|wound healing	apical plasma membrane|extracellular region|extracellular space|integral to membrane|nucleus|plasma membrane	cytokine activity|ErbB-3 class receptor binding|growth factor activity|growth factor activity|protein binding|protein tyrosine kinase activator activity|receptor tyrosine kinase binding|transcription cofactor activity|transmembrane receptor protein tyrosine kinase activator activity				0		Breast(100;0.203)		KIRC - Kidney renal clear cell carcinoma(67;0.0768)|Kidney(114;0.0943)		GATGTCATCCGTAGAAAACAG	0.527			NA											35	98					0	0	0.002522	0	0
RNF122	79845	broad.mit.edu	37	8	33416289	33416289	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr8:33416289C>A	uc003xjo.1	-	2	428	c.26G>T	c.(25-27)GGG>GTG	p.G9V		NM_024787	NP_079063	Q9H9V4	RN122_HUMAN	ring finger protein 122	9						endoplasmic reticulum|Golgi apparatus|integral to membrane	zinc ion binding				0				KIRC - Kidney renal clear cell carcinoma(67;0.0966)|Kidney(114;0.116)		ACAGAAACACCCTGCAAAGGG	0.468			NA											7	23					5.18039e-06	6.18734e-06	0.00308	1	0
KCNU1	157855	broad.mit.edu	37	8	36793066	36793066	+	Silent	SNP	G	G	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr8:36793066G>A	uc010lvw.2	+	27	3165	c.3078G>A	c.(3076-3078)AAG>AAA	p.K1026K		NM_001031836	NP_001027006	A8MYU2	KCNU1_HUMAN	potassium channel, subfamily U, member 1	1026	Cytoplasmic (Potential).					voltage-gated potassium channel complex	binding|large conductance calcium-activated potassium channel activity|voltage-gated potassium channel activity			ovary(1)	1				KIRC - Kidney renal clear cell carcinoma(67;0.0504)|Kidney(114;0.0634)		ATGAGTTCAAGCTGCTGCCTT	0.448			NA											40	73					0	0	0.00361	0	0
GPR124	25960	broad.mit.edu	37	8	37687411	37687411	+	Silent	SNP	C	C	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr8:37687411C>T	uc003xkj.2	+	6	960	c.597C>T	c.(595-597)CGC>CGT	p.R199R	GPR124_uc010lvy.2_Silent_p.R199R	NM_032777	NP_116166	Q96PE1	GP124_HUMAN	G protein-coupled receptor 124 precursor	199	Extracellular (Potential).|LRRCT.				central nervous system development|endothelial cell migration|neuropeptide signaling pathway|regulation of angiogenesis|regulation of chemotaxis|sprouting angiogenesis	integral to membrane|plasma membrane	G-protein coupled receptor activity			large_intestine(2)|ovary(2)|skin(1)	5			BRCA - Breast invasive adenocarcinoma(5;2.75e-24)|LUSC - Lung squamous cell carcinoma(8;3.5e-10)			GCCACCTGCGCTGGCTGCTGC	0.667			NA											20	54					0	0	0.00333	0	0
ANK1	286	broad.mit.edu	37	8	41530083	41530083	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr8:41530083C>A	uc003xok.2	-	38	4969	c.4885G>T	c.(4885-4887)GAT>TAT	p.D1629Y	NKX6-3_uc010lxa.1_Intron|ANK1_uc003xoh.2_Intron|ANK1_uc003xoi.2_Missense_Mutation_p.D1629Y|ANK1_uc003xoj.2_Missense_Mutation_p.D1629Y|ANK1_uc003xol.2_Intron|ANK1_uc003xom.2_Missense_Mutation_p.D1670Y	NM_020476	NP_065209	P16157	ANK1_HUMAN	ankyrin 1 isoform 1	1629	55 kDa regulatory domain.				axon guidance|cytoskeleton organization|exocytosis|maintenance of epithelial cell apical/basal polarity|signal transduction	basolateral plasma membrane|cytosol|sarcomere|sarcoplasmic reticulum|spectrin-associated cytoskeleton	cytoskeletal adaptor activity|enzyme binding|protein binding|spectrin binding|structural constituent of cytoskeleton			ovary(3)|central_nervous_system(3)|lung(2)|breast(1)	9	Ovarian(28;0.00541)|Colorectal(14;0.0398)|Lung SC(25;0.211)	all_lung(54;0.000626)|Lung NSC(58;0.00245)|Esophageal squamous(32;0.0559)|Hepatocellular(245;0.0663)|Renal(179;0.188)	OV - Ovarian serous cystadenocarcinoma(14;0.000984)|Lung(22;0.00108)|Colorectal(10;0.00245)|LUSC - Lung squamous cell carcinoma(45;0.00392)|COAD - Colon adenocarcinoma(11;0.0264)			TTTGTGGCATCTGAATCCACT	0.567			NA											49	129					1.00776e-21	1.70288e-21	0.00361	1	0
ANK1	286	broad.mit.edu	37	8	41580669	41580669	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr8:41580669C>A	uc003xok.2	-	9	967	c.883G>T	c.(883-885)GGG>TGG	p.G295W	NKX6-3_uc010lxa.1_Intron|ANK1_uc003xoi.2_Missense_Mutation_p.G295W|ANK1_uc003xoj.2_Missense_Mutation_p.G295W|ANK1_uc003xol.2_Missense_Mutation_p.G295W|ANK1_uc003xom.2_Missense_Mutation_p.G328W	NM_020476	NP_065209	P16157	ANK1_HUMAN	ankyrin 1 isoform 1	295	ANK 8.|89 kDa domain.				axon guidance|cytoskeleton organization|exocytosis|maintenance of epithelial cell apical/basal polarity|signal transduction	basolateral plasma membrane|cytosol|sarcomere|sarcoplasmic reticulum|spectrin-associated cytoskeleton	cytoskeletal adaptor activity|enzyme binding|protein binding|spectrin binding|structural constituent of cytoskeleton			ovary(3)|central_nervous_system(3)|lung(2)|breast(1)	9	Ovarian(28;0.00541)|Colorectal(14;0.0398)|Lung SC(25;0.211)	all_lung(54;0.000626)|Lung NSC(58;0.00245)|Esophageal squamous(32;0.0559)|Hepatocellular(245;0.0663)|Renal(179;0.188)	OV - Ovarian serous cystadenocarcinoma(14;0.000984)|Lung(22;0.00108)|Colorectal(10;0.00245)|LUSC - Lung squamous cell carcinoma(45;0.00392)|COAD - Colon adenocarcinoma(11;0.0264)			ATTGGTGCCCCGTGGTCCAGC	0.502			NA											23	70					1.16021e-09	1.58715e-09	0.007291	1	0
IKBKB	3551	broad.mit.edu	37	8	42146232	42146232	+	Silent	SNP	C	C	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr8:42146232C>T	uc003xow.1	+	3	363	c.186C>T	c.(184-186)ATC>ATT	p.I62I	IKBKB_uc003xov.2_Silent_p.I62I|IKBKB_uc010lxh.1_Intron|IKBKB_uc011lco.1_Intron|IKBKB_uc010lxj.1_Intron|IKBKB_uc003xox.1_5'UTR|IKBKB_uc011lcp.1_RNA|IKBKB_uc011lcq.1_Silent_p.I60I|IKBKB_uc010lxi.1_RNA|IKBKB_uc011lcr.1_Intron	NM_001556	NP_001547	O14920	IKKB_HUMAN	inhibitor of nuclear factor kappa B kinase beta	62	Protein kinase.				anti-apoptosis|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of transcription, DNA-dependent|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	CD40 receptor complex|cytosol|internal side of plasma membrane|membrane raft	ATP binding|identical protein binding|IkappaB kinase activity			breast(3)|ovary(2)|lung(1)|skin(1)	7	all_cancers(6;1.42e-24)|all_epithelial(6;1.02e-25)|all_lung(13;6.21e-12)|Lung NSC(13;1.04e-10)|Ovarian(28;0.00769)|Prostate(17;0.0119)|Colorectal(14;0.0468)|Lung SC(25;0.211)	all_lung(54;0.000434)|Lung NSC(58;0.00161)|Hepatocellular(245;0.0524)|Renal(179;0.0822)|Esophageal squamous(32;0.0954)	BRCA - Breast invasive adenocarcinoma(8;1.37e-10)|Colorectal(10;0.00102)|OV - Ovarian serous cystadenocarcinoma(14;0.00168)|Lung(22;0.00467)|LUSC - Lung squamous cell carcinoma(45;0.024)|COAD - Colon adenocarcinoma(11;0.0264)		Arsenic trioxide(DB01169)|Auranofin(DB00995)	GCCTGGAGATCCAGATCATGA	0.562			NA											6	11					0	0	0.001984	0	0
PRKDC	5591	broad.mit.edu	37	8	48689479	48689479	+	Missense_Mutation	SNP	T	T	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr8:48689479T>A	uc003xqi.2	-	86	12165	c.12108A>T	c.(12106-12108)AAA>AAT	p.K4036N	PRKDC_uc003xqj.2_Missense_Mutation_p.K4005N|PRKDC_uc011ldh.1_Intron	NM_006904	NP_008835	P78527	PRKDC_HUMAN	protein kinase, DNA-activated, catalytic	4036					cellular response to insulin stimulus|double-strand break repair via nonhomologous end joining|peptidyl-serine phosphorylation|positive regulation of transcription from RNA polymerase II promoter	DNA-dependent protein kinase-DNA ligase 4 complex|transcription factor complex	ATP binding|DNA binding|DNA-dependent protein kinase activity|transcription factor binding			lung(12)|central_nervous_system(9)|ovary(6)|skin(4)|large_intestine(3)	34		all_cancers(86;0.0336)|all_epithelial(80;0.00111)|Lung NSC(129;0.00363)|all_lung(136;0.00391)				GGTACCAATTTTTTTCAGCAA	0.358	Esophageal Squamous(79;1091 1253 12329 31680 40677)		NA						NHEJ					15	18					0	0	0.00499	0	0
SNTG1	54212	broad.mit.edu	37	8	51617258	51617258	+	Silent	SNP	C	C	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr8:51617258C>T	uc010lxy.1	+	17	1508	c.1137C>T	c.(1135-1137)GCC>GCT	p.A379A	SNTG1_uc003xqs.1_Silent_p.A379A|SNTG1_uc010lxz.1_Silent_p.A379A|SNTG1_uc011ldl.1_RNA	NM_018967	NP_061840	Q9NSN8	SNTG1_HUMAN	syntrophin, gamma 1	379	PH.				cell communication	cytoplasm|cytoskeleton|nucleus|ruffle membrane|syntrophin complex	actin binding|protein C-terminus binding			ovary(5)	5		all_cancers(86;0.00754)|all_epithelial(80;9.76e-05)|Lung NSC(129;0.000865)|all_lung(136;0.00249)|Colorectal(162;0.22)				GTGACCTCGCCCAGTGGGAAA	0.552			NA											37	33					0	0	0.005524	0	0
SNTG1	54212	broad.mit.edu	37	8	51705290	51705290	+	Silent	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr8:51705290C>A	uc010lxy.1	+	20	1826	c.1455C>A	c.(1453-1455)GCC>GCA	p.A485A	SNTG1_uc003xqs.1_Silent_p.A485A|SNTG1_uc010lxz.1_Silent_p.A448A|SNTG1_uc011ldl.1_RNA	NM_018967	NP_061840	Q9NSN8	SNTG1_HUMAN	syntrophin, gamma 1	485					cell communication	cytoplasm|cytoskeleton|nucleus|ruffle membrane|syntrophin complex	actin binding|protein C-terminus binding			ovary(5)	5		all_cancers(86;0.00754)|all_epithelial(80;9.76e-05)|Lung NSC(129;0.000865)|all_lung(136;0.00249)|Colorectal(162;0.22)				TCTTTGCTGCCAAGGTAGCTT	0.398			NA											19	141					9.7654e-05	0.000110595	0.007413	1	0
SNTG1	54212	broad.mit.edu	37	8	51705359	51705359	+	Silent	SNP	T	T	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr8:51705359T>A	uc010lxy.1	+	20	1895	c.1524T>A	c.(1522-1524)GCT>GCA	p.A508A	SNTG1_uc003xqs.1_Silent_p.A508A|SNTG1_uc010lxz.1_Silent_p.A471A|SNTG1_uc011ldl.1_RNA	NM_018967	NP_061840	Q9NSN8	SNTG1_HUMAN	syntrophin, gamma 1	508					cell communication	cytoplasm|cytoskeleton|nucleus|ruffle membrane|syntrophin complex	actin binding|protein C-terminus binding			ovary(5)	5		all_cancers(86;0.00754)|all_epithelial(80;9.76e-05)|Lung NSC(129;0.000865)|all_lung(136;0.00249)|Colorectal(162;0.22)				CCAGCTCTGCTACCACGAGCA	0.428			NA											66	69					0	0	0.00361	0	0
PXDNL	137902	broad.mit.edu	37	8	52232491	52232491	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr8:52232491C>G	uc003xqu.3	-	23	4453	c.4352G>C	c.(4351-4353)AGA>ACA	p.R1451T	PXDNL_uc003xqt.3_RNA	NM_144651	NP_653252	A1KZ92	PXDNL_HUMAN	peroxidasin homolog-like precursor	1451	VWFC.				hydrogen peroxide catabolic process	extracellular space	heme binding|peroxidase activity			ovary(1)|pancreas(1)	2		all_cancers(86;0.107)|Lung NSC(129;0.00641)|all_epithelial(80;0.00716)|all_lung(136;0.015)				TCCTCGGTCTCTGCAAACTGG	0.512			NA											15	28					0	0	0.006122	0	0
PXDNL	137902	broad.mit.edu	37	8	52366326	52366326	+	Silent	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr8:52366326G>T	uc003xqu.3	-	10	1103	c.1002C>A	c.(1000-1002)ATC>ATA	p.I334I		NM_144651	NP_653252	A1KZ92	PXDNL_HUMAN	peroxidasin homolog-like precursor	334	Ig-like C2-type 2.				hydrogen peroxide catabolic process	extracellular space	heme binding|peroxidase activity			ovary(1)|pancreas(1)	2		all_cancers(86;0.107)|Lung NSC(129;0.00641)|all_epithelial(80;0.00716)|all_lung(136;0.015)				CCTGAGGCTGGATTACAAAGC	0.448			NA											14	83					1.45105e-14	2.22216e-14	0.006122	1	0
ST18	9705	broad.mit.edu	37	8	53062531	53062531	+	Missense_Mutation	SNP	C	C	T	rs144486751		TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr8:53062531C>T	uc003xqz.2	-	11	1969	c.1813G>A	c.(1813-1815)GAA>AAA	p.E605K	ST18_uc011ldq.1_Missense_Mutation_p.E252K|ST18_uc011ldr.1_Missense_Mutation_p.E570K|ST18_uc011lds.1_Missense_Mutation_p.E510K|ST18_uc003xra.2_Missense_Mutation_p.E605K|ST18_uc003xrb.2_Missense_Mutation_p.E605K	NM_014682	NP_055497	O60284	ST18_HUMAN	suppression of tumorigenicity 18	605						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)|skin(1)	5		Lung NSC(129;0.131)|all_epithelial(80;0.217)|all_lung(136;0.229)				ACTTCTATTTCGGCTCCCTGG	0.398			NA											4	105					0	0	0.001984	0	0
XKR4	114786	broad.mit.edu	37	8	56436132	56436132	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr8:56436132C>A	uc003xsf.2	+	3	1331	c.1299C>A	c.(1297-1299)TTC>TTA	p.F433L		NM_052898	NP_443130	Q5GH76	XKR4_HUMAN	XK, Kell blood group complex subunit-related	433	Helical; (Potential).					integral to membrane				pancreas(2)	2			Epithelial(17;0.000117)|all cancers(17;0.000836)			AGATTGTGTTCGACATGGTGG	0.443			NA											142	121					3.03755e-85	5.71752e-85	0.00361	1	0
IMPAD1	54928	broad.mit.edu	37	8	57876397	57876397	+	Silent	SNP	G	G	C			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr8:57876397G>C	uc003xte.3	-	5	1318	c.1035C>G	c.(1033-1035)GCC>GCG	p.A345A		NM_017813	NP_060283	Q9NX62	IMPA3_HUMAN	inositol monophosphatase domain containing 1	345						Golgi apparatus|integral to membrane	inositol-1(or 4)-monophosphatase activity|metal ion binding			ovary(1)	1		all_cancers(86;0.175)|all_lung(136;0.0321)|Lung NSC(129;0.0417)|all_epithelial(80;0.0448)				TTCTGACCAGGGCCTGGTGGT	0.473			NA											44	108					0	0	0.00361	0	0
IMPAD1	54928	broad.mit.edu	37	8	57878817	57878817	+	Silent	SNP	C	C	G			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr8:57878817C>G	uc003xte.3	-	4	1024	c.741G>C	c.(739-741)GGG>GGC	p.G247G		NM_017813	NP_060283	Q9NX62	IMPA3_HUMAN	inositol monophosphatase domain containing 1	247						Golgi apparatus|integral to membrane	inositol-1(or 4)-monophosphatase activity|metal ion binding			ovary(1)	1		all_cancers(86;0.175)|all_lung(136;0.0321)|Lung NSC(129;0.0417)|all_epithelial(80;0.0448)				GTTTGACCATCCCTGAATGGG	0.493			NA											20	70					0	0	0.001882	0	0
PREX2	80243	broad.mit.edu	37	8	69011923	69011923	+	Nonsense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr8:69011923G>T	uc003xxv.1	+	23	2587	c.2560G>T	c.(2560-2562)GAA>TAA	p.E854*	PREX2_uc003xxu.1_Nonsense_Mutation_p.E854*|PREX2_uc011lez.1_Nonsense_Mutation_p.E789*	NM_024870	NP_079146	Q70Z35	PREX2_HUMAN	DEP domain containing 2 isoform a	854					G-protein coupled receptor protein signaling pathway|intracellular signal transduction	intracellular	protein binding|Rac GTPase activator activity|Rac guanyl-nucleotide exchange factor activity			skin(6)|large_intestine(4)|pancreas(3)|lung(2)|ovary(1)|kidney(1)	17						GCAGATTCTTGAAGCCCTGGC	0.269			NA											26	71					3.73988e-18	6.09113e-18	0.00632	1	0
XKR9	389668	broad.mit.edu	37	8	71593456	71593456	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr8:71593456G>T	uc003xyq.2	+	3	697	c.163G>T	c.(163-165)GCT>TCT	p.A55S	XKR9_uc010lze.2_Missense_Mutation_p.A55S|XKR9_uc010lzd.2_5'UTR	NM_001011720	NP_001011720	Q5GH70	XKR9_HUMAN	XK, Kell blood group complex subunit-related	55	Helical; (Potential).					integral to membrane				ovary(1)|skin(1)	2	Breast(64;0.0716)		Epithelial(68;0.00301)|all cancers(69;0.0165)|OV - Ovarian serous cystadenocarcinoma(28;0.0524)|BRCA - Breast invasive adenocarcinoma(89;0.166)			AACACTTGTGGCTCAGTGTTT	0.373			NA											37	236					2.24893e-16	3.58047e-16	0.009718	1	0
TRPA1	8989	broad.mit.edu	37	8	72983985	72983985	+	Nonsense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr8:72983985C>A	uc003xza.2	-	2	404	c.229G>T	c.(229-231)GAG>TAG	p.E77*		NM_007332	NP_015628	O75762	TRPA1_HUMAN	ankyrin-like protein 1	77	Cytoplasmic (Potential).|ANK 1.					integral to plasma membrane				ovary(4)|lung(1)|kidney(1)	6			Epithelial(68;0.223)		Menthol(DB00825)	TCCATTAGCTCAATTTGGCCT	0.343			NA											31	31					3.33393e-15	5.16951e-15	0.004878	1	0
CRISPLD1	83690	broad.mit.edu	37	8	75898471	75898471	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr8:75898471G>A	uc003yan.2	+	2	624	c.249G>A	c.(247-249)ATG>ATA	p.M83I		NM_031461	NP_113649	Q9H336	CRLD1_HUMAN	cysteine-rich secretory protein LCCL domain	83						extracellular region				ovary(1)|central_nervous_system(1)	2	Breast(64;0.0799)		Epithelial(68;0.155)|BRCA - Breast invasive adenocarcinoma(89;0.161)			CCTCTAATATGGAGTATATGG	0.358			NA											20	130					0	0	0.003954	0	0
ZFHX4	79776	broad.mit.edu	37	8	77766314	77766314	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr8:77766314G>C	uc003yav.2	+	10	7409	c.7022G>C	c.(7021-7023)GGG>GCG	p.G2341A	ZFHX4_uc003yau.1_Missense_Mutation_p.G2386A|ZFHX4_uc003yaw.1_Missense_Mutation_p.G2341A	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	2341						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			TCTGGCTCTGGGACCAGCACC	0.522			NA								HNSCC(33;0.089)			16	34					0	0	0.003163	0	0
ATP6V0D2	245972	broad.mit.edu	37	8	87163695	87163695	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr8:87163695G>A	uc003ydp.1	+	7	886	c.817G>A	c.(817-819)GTA>ATA	p.V273I		NM_152565	NP_689778	Q8N8Y2	VA0D2_HUMAN	ATPase, H+ transporting, lysosomal 38kDa, V0	273					ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|insulin receptor signaling pathway|transferrin transport	apical plasma membrane|endosome membrane|proton-transporting V-type ATPase, V0 domain|vacuolar proton-transporting V-type ATPase complex	hydrogen ion transmembrane transporter activity|protein binding				0						TGTTTTTAAGGTATACAAACC	0.294			NA											25	33					0	0	0.005443	0	0
CNGB3	54714	broad.mit.edu	37	8	87666257	87666257	+	Missense_Mutation	SNP	T	T	G			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr8:87666257T>G	uc003ydx.2	-	7	932	c.886A>C	c.(886-888)ACT>CCT	p.T296P	CNGB3_uc010maj.2_Missense_Mutation_p.T158P	NM_019098	NP_061971	Q9NQW8	CNGB3_HUMAN	cyclic nucleotide gated channel beta 3	296	Cytoplasmic (Potential).				signal transduction|visual perception	integral to membrane	cGMP binding			ovary(2)|pancreas(1)	3						TTTGTAGAAGTCCTGTAGTGT	0.264			NA											36	40					0	0	0.009718	0	0
CNGB3	54714	broad.mit.edu	37	8	87679267	87679267	+	Silent	SNP	G	G	C			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr8:87679267G>C	uc003ydx.2	-	6	784	c.738C>G	c.(736-738)ACC>ACG	p.T246T	CNGB3_uc010maj.2_Silent_p.T108T	NM_019098	NP_061971	Q9NQW8	CNGB3_HUMAN	cyclic nucleotide gated channel beta 3	246	Extracellular (Potential).				signal transduction|visual perception	integral to membrane	cGMP binding			ovary(2)|pancreas(1)	3						TGTTGTCTGCGGTTTGATATG	0.438			NA											40	55					0	0	0.00361	0	0
MMP16	4325	broad.mit.edu	37	8	89128842	89128843	+	Missense_Mutation	DNP	GG	GG	CT			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr8:89128842_89128843GG>CT	uc003yeb.3	-	6	1258_1259	c.976_977CC>AG	c.(976-978)CCT>AGT	p.P326S	MMP16_uc003yec.2_Missense_Mutation_p.P326S	NM_005941	NP_005932	P51512	MMP16_HUMAN	matrix metalloproteinase 16 isoform 1	326	Extracellular (Potential).				collagen catabolic process|proteolysis	cell surface|integral to plasma membrane|proteinaceous extracellular matrix	calcium ion binding|enzyme activator activity|metalloendopeptidase activity|zinc ion binding			upper_aerodigestive_tract(2)|ovary(2)|central_nervous_system(1)|urinary_tract(1)|skin(1)|kidney(1)	8						TGGAGGCCGAGGAGGTTTTGGC	0.53			NA											83	83					0	0	0.004672	0	0
DPY19L4	286148	broad.mit.edu	37	8	95750606	95750606	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr8:95750606C>T	uc003ygx.2	+	4	386	c.262C>T	c.(262-264)CGG>TGG	p.R88W	DPY19L4_uc003ygy.2_Missense_Mutation_p.R25W	NM_181787	NP_861452	Q7Z388	D19L4_HUMAN	dpy-19-like 4	88						integral to membrane				ovary(2)	2	Breast(36;3.85e-06)					GGAGCTTGAACGGGAAATCAC	0.214			NA											17	64					0	0	0.008871	0	0
C8orf47	203111	broad.mit.edu	37	8	99102061	99102061	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr8:99102061C>A	uc003yih.1	+	2	964	c.816C>A	c.(814-816)GAC>GAA	p.D272E		NM_173549	NP_775820	Q6P6B1	CH047_HUMAN	hypothetical protein LOC203111	272	Glu-rich.										0	Breast(36;2.31e-06)		OV - Ovarian serous cystadenocarcinoma(57;0.214)			AAGTATTGGACAGAAGTCAGC	0.443			NA											8	47					5.18039e-06	6.18734e-06	0.00308	1	0
ZFPM2	23414	broad.mit.edu	37	8	106815464	106815464	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr8:106815464G>A	uc003ymd.2	+	8	3177	c.3154G>A	c.(3154-3156)GAG>AAG	p.E1052K	ZFPM2_uc011lhs.1_Missense_Mutation_p.E783K	NM_012082	NP_036214	Q8WW38	FOG2_HUMAN	zinc finger protein, multitype 2	1052					blood coagulation|negative regulation of fat cell differentiation|outflow tract septum morphogenesis|right ventricular cardiac muscle tissue morphogenesis|ventricular septum morphogenesis	nucleoplasm	DNA binding|RNA polymerase II transcription coactivator activity|transcription corepressor activity|transcription factor binding|zinc ion binding			ovary(4)|large_intestine(1)	5			OV - Ovarian serous cystadenocarcinoma(57;8.28e-08)			GAAACAAGATGAGAGACCTGC	0.488			NA											3	22					0	0	0.009096	0	0
NUDCD1	84955	broad.mit.edu	37	8	110308681	110308681	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr8:110308681C>T	uc003ynb.3	-	3	502	c.391G>A	c.(391-393)GAT>AAT	p.D131N	NUDCD1_uc003yna.2_Missense_Mutation_p.D102N|NUDCD1_uc010mcl.2_Missense_Mutation_p.D44N|NUDCD1_uc010mcm.1_Missense_Mutation_p.D44N	NM_032869	NP_116258	Q96RS6	NUDC1_HUMAN	NudC domain containing 1 isoform 1	131										ovary(1)|breast(1)	2	all_neural(195;0.219)		OV - Ovarian serous cystadenocarcinoma(57;1.56e-12)			CCAGTTCCATCTGACAAGGTA	0.443			NA											49	180					0	0	0.00361	0	0
CSMD3	114788	broad.mit.edu	37	8	113966912	113966912	+	Splice_Site	SNP	C	C	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr8:113966912C>T	uc003ynu.2	-	8	1579	c.1420_splice	c.e8+1	p.L474_splice	CSMD3_uc003ynt.2_Splice_Site_p.L434_splice|CSMD3_uc011lhx.1_Splice_Site_p.L370_splice	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1							integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						AGTACACTCACAGATAGAAAA	0.318			NA								HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			20	14					0	0	0.00278	0	0
TRPS1	7227	broad.mit.edu	37	8	116631712	116631712	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr8:116631712C>A	uc003ynz.2	-	2	1033	c.574G>T	c.(574-576)GAT>TAT	p.D192Y	TRPS1_uc011lhy.1_Missense_Mutation_p.D196Y|TRPS1_uc003yny.2_Missense_Mutation_p.D205Y|TRPS1_uc010mcy.2_Missense_Mutation_p.D192Y	NM_014112	NP_054831	Q9UHF7	TRPS1_HUMAN	zinc finger transcription factor TRPS1	192					negative regulation of transcription from RNA polymerase II promoter|NLS-bearing substrate import into nucleus|regulation of chondrocyte differentiation|skeletal system development|transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)|skin(2)|pancreas(1)|lung(1)|kidney(1)	7	all_cancers(13;5.44e-23)|all_epithelial(1;2.14e-27)|Lung NSC(37;2.55e-05)|Ovarian(258;0.0219)		Epithelial(1;9.78e-37)|all cancers(1;3.14e-31)|BRCA - Breast invasive adenocarcinoma(1;2.56e-12)			ACACCCCCATCTGAAGGCACT	0.478			NA							Langer-Giedion_syndrome				69	64					2.48295e-43	4.56384e-43	0.00361	1	0
COL14A1	7373	broad.mit.edu	37	8	121224795	121224795	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr8:121224795G>A	uc003yox.2	+	13	1841	c.1576G>A	c.(1576-1578)GTT>ATT	p.V526I	COL14A1_uc003yoy.2_Missense_Mutation_p.V204I|COL14A1_uc010mde.1_Missense_Mutation_p.V204I	NM_021110	NP_066933	Q05707	COEA1_HUMAN	collagen, type XIV, alpha 1 precursor	526	Fibronectin type-III 3.				cell-cell adhesion|collagen fibril organization	collagen type XIV|extracellular space	collagen binding|extracellular matrix structural constituent|protein binding, bridging			ovary(4)|kidney(4)|skin(2)|pancreas(1)|central_nervous_system(1)	12	Lung NSC(37;6.52e-07)|Ovarian(258;0.00769)|Hepatocellular(40;0.161)		OV - Ovarian serous cystadenocarcinoma(1;6.47e-38)|STAD - Stomach adenocarcinoma(47;0.00503)			CAGTGATCCTGTTACGGGACA	0.453			NA											19	86					0	0	0.005443	0	0
WDR67	93594	broad.mit.edu	37	8	124162330	124162330	+	Missense_Mutation	SNP	A	A	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr8:124162330A>T	uc003ypp.1	+	21	3119	c.3029A>T	c.(3028-3030)CAA>CTA	p.Q1010L	WDR67_uc011lig.1_Missense_Mutation_p.Q914L|WDR67_uc011lih.1_Missense_Mutation_p.Q900L|WDR67_uc003ypq.1_RNA|WDR67_uc003yps.1_Missense_Mutation_p.Q644L|WDR67_uc003ypt.1_Missense_Mutation_p.Q402L|WDR67_uc003ypu.1_Missense_Mutation_p.Q402L	NM_145647	NP_663622	Q96DN5	WDR67_HUMAN	WD repeat domain 67 isoform 1	1010						centrosome	Rab GTPase activator activity			skin(1)	1	Lung NSC(37;7e-10)|Ovarian(258;0.0205)		STAD - Stomach adenocarcinoma(47;0.00527)			AGAACCTCACAATTAAATGAC	0.353			NA											27	31					0	0	0.003755	0	0
FAM83A	84985	broad.mit.edu	37	8	124195292	124195292	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr8:124195292G>T	uc003ypv.2	+	2	2210	c.196G>T	c.(196-198)GTG>TTG	p.V66L	FAM83A_uc003ypw.2_Missense_Mutation_p.V66L|FAM83A_uc003ypy.2_Missense_Mutation_p.V66L|FAM83A_uc003ypx.2_Missense_Mutation_p.V66L|FAM83A_uc003ypz.2_Missense_Mutation_p.V66L	NM_032899	NP_116288	Q86UY5	FA83A_HUMAN	hypothetical protein LOC84985 isoform a	66										ovary(3)|skin(1)	4	Lung NSC(37;1.55e-09)|Ovarian(258;0.0205)		STAD - Stomach adenocarcinoma(47;0.00527)			CTTGTCCTCGGTGGAGGCCCA	0.682			NA											16	18					0.000566183	0.000622257	0.00499	1	0
MTSS1	9788	broad.mit.edu	37	8	125603473	125603473	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr8:125603473C>A	uc003yrk.2	-	4	746	c.212G>T	c.(211-213)GGG>GTG	p.G71V	MTSS1_uc003yrj.2_Missense_Mutation_p.G71V|MTSS1_uc003yrl.2_Missense_Mutation_p.G71V	NM_014751	NP_055566	O43312	MTSS1_HUMAN	metastasis suppressor 1	71	IMD.				actin cytoskeleton organization|cell adhesion|cellular component movement|filopodium assembly|transmembrane receptor protein tyrosine kinase signaling pathway	actin cytoskeleton|endocytic vesicle|ruffle	actin monomer binding|cytoskeletal adaptor activity|receptor binding|SH3 domain binding			ovary(1)	1	Ovarian(258;0.00438)|all_neural(195;0.00459)|Hepatocellular(40;0.108)		STAD - Stomach adenocarcinoma(47;0.00288)			CTCCCTGGTCCCACCTGAAAA	0.483	Esophageal Squamous(160;622 1893 3862 8546 12509)		NA											9	64					4.68919e-08	6.0898e-08	0.008291	1	0
GSDMC	56169	broad.mit.edu	37	8	130762748	130762748	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr8:130762748G>T	uc003ysr.2	-	11	1894	c.1012C>A	c.(1012-1014)CAG>AAG	p.Q338K		NM_031415	NP_113603	Q9BYG8	GSDMC_HUMAN	melanoma-derived leucine zipper, extra-nuclear	338						mitochondrion				ovary(2)|skin(1)	3						ATGACATCCTGAACATCCTTT	0.493			NA											46	40					2.43468e-25	4.23435e-25	0.00361	1	0
EFR3A	23167	broad.mit.edu	37	8	133014952	133014952	+	Missense_Mutation	SNP	A	A	C			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr8:133014952A>C	uc003yte.2	+	21	2510	c.2309A>C	c.(2308-2310)AAA>ACA	p.K770T		NM_015137	NP_055952	Q14156	EFR3A_HUMAN	EFR3 homolog A	770						plasma membrane	binding			ovary(3)|breast(1)|central_nervous_system(1)	5	Esophageal squamous(12;0.00693)|Ovarian(258;0.00769)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000805)|LUAD - Lung adenocarcinoma(14;0.102)			TGTGAATCCAAAGTAAGTGAA	0.408			NA											25	22					0	0	0.009535	0	0
EFR3A	23167	broad.mit.edu	37	8	133015496	133015496	+	Missense_Mutation	SNP	A	A	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr8:133015496A>T	uc003yte.2	+	22	2525	c.2324A>T	c.(2323-2325)CAT>CTT	p.H775L		NM_015137	NP_055952	Q14156	EFR3A_HUMAN	EFR3 homolog A	775						plasma membrane	binding			ovary(3)|breast(1)|central_nervous_system(1)	5	Esophageal squamous(12;0.00693)|Ovarian(258;0.00769)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000805)|LUAD - Lung adenocarcinoma(14;0.102)			AATTTGCTTCATGATAGACTT	0.318			NA											13	66					0	0	0.00245	0	0
FAM135B	51059	broad.mit.edu	37	8	139380195	139380195	+	Nonsense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr8:139380195G>T	uc003yuy.2	-	2	203	c.32C>A	c.(31-33)TCG>TAG	p.S11*	FAM135B_uc003yux.2_5'UTR|FAM135B_uc003yuz.2_RNA	NM_015912	NP_056996	Q49AJ0	F135B_HUMAN	hypothetical protein LOC51059	11										ovary(7)|skin(2)	9	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			TAGCTCTACCGAAAACTCAAC	0.303			NA								HNSCC(54;0.14)			48	65					7.10663e-31	1.26406e-30	0.00361	1	0
COL22A1	169044	broad.mit.edu	37	8	139620186	139620186	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr8:139620186C>A	uc003yvd.2	-	57	4472	c.4025G>T	c.(4024-4026)GGA>GTA	p.G1342V	COL22A1_uc011ljo.1_Missense_Mutation_p.G622V	NM_152888	NP_690848	Q8NFW1	COMA1_HUMAN	collagen, type XXII, alpha 1	1342	Pro-rich.|Gly-rich.|Collagen-like 13.				cell adhesion	collagen|cytoplasm	structural molecule activity			ovary(11)|pancreas(1)|skin(1)	13	all_epithelial(106;1.55e-12)|Lung NSC(106;1.67e-05)|all_lung(105;3.39e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0517)			CACAGGGGTTCCTGAAGGGCC	0.502			NA								HNSCC(7;0.00092)			21	67					2.27731e-05	2.63735e-05	0.001882	1	0
COL22A1	169044	broad.mit.edu	37	8	139767420	139767420	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr8:139767420G>T	uc003yvd.2	-	21	2458	c.2011C>A	c.(2011-2013)CCC>ACC	p.P671T	COL22A1_uc011ljo.1_5'UTR	NM_152888	NP_690848	Q8NFW1	COMA1_HUMAN	collagen, type XXII, alpha 1	671	Pro-rich.|Gly-rich.|Collagen-like 4.				cell adhesion	collagen|cytoplasm	structural molecule activity			ovary(11)|pancreas(1)|skin(1)	13	all_epithelial(106;1.55e-12)|Lung NSC(106;1.67e-05)|all_lung(105;3.39e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0517)			GGAGGACCGGGGGCGCCTTGG	0.557			NA								HNSCC(7;0.00092)			23	68					1.5548e-18	2.53786e-18	0.005443	1	0
CYP11B1	1584	broad.mit.edu	37	8	143955804	143955804	+	Silent	SNP	G	G	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr8:143955804G>A	uc003yxi.2	-	9	1504	c.1497C>T	c.(1495-1497)TTC>TTT	p.F499F	CYP11B1_uc010mex.2_Silent_p.F198F|CYP11B1_uc003yxh.2_Silent_p.F149F|CYP11B1_uc003yxj.2_Silent_p.F433F|CYP11B1_uc010mey.2_Silent_p.F570F	NM_000497	NP_000488	P15538	C11B1_HUMAN	cytochrome P450, family 11, subfamily B,	499					aldosterone biosynthetic process|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|glucose homeostasis|immune response|regulation of blood pressure|response to stress|xenobiotic metabolic process	mitochondrial inner membrane	electron carrier activity|steroid 11-beta-monooxygenase activity			ovary(3)	3	all_cancers(97;4.74e-11)|all_epithelial(106;2.06e-08)|Lung NSC(106;0.000228)|all_lung(105;0.000633)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)				Mitotane(DB00648)	TGATGGCTCTGAAGGTGAGGA	0.567			NA							Familial_Hyperaldosteronism_type_I				33	49					0	0	0.002852	0	0
RHPN1	114822	broad.mit.edu	37	8	144464036	144464036	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr8:144464036G>T	uc003yyb.2	+	14	1828	c.1695G>T	c.(1693-1695)TGG>TGT	p.W565C		NM_052924	NP_443156	Q8TCX5	RHPN1_HUMAN	rhophilin 1	590	PDZ.				signal transduction	intracellular				large_intestine(1)	1	all_cancers(97;7.39e-11)|all_epithelial(106;5.44e-09)|Lung NSC(106;0.000167)|all_lung(105;0.000459)|Ovarian(258;0.0212)|Acute lymphoblastic leukemia(118;0.155)		Colorectal(110;0.107)|BRCA - Breast invasive adenocarcinoma(115;0.156)			CATGCAGGTGGTGGAGACACG	0.662			NA											24	29					3.90053e-15	6.03547e-15	0.002445	1	0
FAM83H	286077	broad.mit.edu	37	8	144811213	144811213	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr8:144811213C>A	uc003yzk.2	-	4	730	c.661G>T	c.(661-663)GGG>TGG	p.G221W	FAM83H_uc010mfk.1_5'Flank	NM_198488	NP_940890	Q6ZRV2	FA83H_HUMAN	FAM83H	221					biomineral tissue development					lung(1)|central_nervous_system(1)|pancreas(1)	3	all_cancers(97;3.74e-11)|all_epithelial(106;2.62e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;3.38e-41)|Epithelial(56;6.8e-40)|all cancers(56;6.43e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.146)			AAGGACTTCCCAGTGCGGCAG	0.652			NA											79	104					1.59803e-59	2.98901e-59	0.00361	1	0
EPPK1	83481	broad.mit.edu	37	8	144941191	144941191	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr8:144941191G>C	uc003zaa.1	-	1	6244	c.6231C>G	c.(6229-6231)GAC>GAG	p.D2077E		NM_031308	NP_112598	P58107	EPIPL_HUMAN	epiplakin 1	2077	Plectin 35.					cytoplasm|cytoskeleton	protein binding|structural molecule activity			pancreas(1)|skin(1)	2	all_cancers(97;1.42e-10)|all_epithelial(106;1.99e-09)|Lung NSC(106;0.000126)|all_lung(105;0.000354)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;2.88e-40)|all cancers(56;1.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			GCCAGCCCGTGTCCTCTTGTG	0.587			NA											6	59					0	0	0.001984	0	0
PLEC	5339	broad.mit.edu	37	8	144991003	144991003	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr8:144991003C>A	uc003zaf.1	-	32	13567	c.13397G>T	c.(13396-13398)CGC>CTC	p.R4466L	PLEC_uc003zab.1_Missense_Mutation_p.R4329L|PLEC_uc003zac.1_Missense_Mutation_p.R4333L|PLEC_uc003zad.2_Missense_Mutation_p.R4329L|PLEC_uc003zae.1_Missense_Mutation_p.R4297L|PLEC_uc003zag.1_Missense_Mutation_p.R4307L|PLEC_uc003zah.2_Missense_Mutation_p.R4315L|PLEC_uc003zaj.2_Missense_Mutation_p.R4356L	NM_201380	NP_958782	Q15149	PLEC_HUMAN	plectin isoform 1	4466	Globular 2.|Plectin 30.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle|structural constituent of muscle			large_intestine(2)|ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	9						GACAGGGAAGCGCTCACCGGT	0.657			NA											34	43					1.47197e-15	2.30645e-15	0.007835	1	0
FBXL6	26233	broad.mit.edu	37	8	145579728	145579728	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr8:145579728C>G	uc003zcb.2	-	8	1397	c.1372G>C	c.(1372-1374)GAG>CAG	p.E458Q	C8ORFK29_uc011llb.1_5'Flank|C8ORFK29_uc010mfw.2_5'Flank|C8ORFK29_uc003zby.3_5'Flank|FBXL6_uc003zbz.2_Missense_Mutation_p.E185Q|FBXL6_uc003zca.2_Missense_Mutation_p.E452Q|FBXL6_uc010mfx.2_Missense_Mutation_p.E219Q|GPR172A_uc003zcc.1_5'Flank|GPR172A_uc003zcd.1_5'Flank|GPR172A_uc003zce.1_5'Flank|GPR172A_uc010mfy.1_5'Flank|GPR172A_uc003zcf.1_5'Flank|GPR172A_uc011llc.1_5'Flank	NM_012162	NP_036294	Q8N531	FBXL6_HUMAN	F-box and leucine-rich repeat protein 6 isoform	458	LRR 10.				proteolysis		ubiquitin-protein ligase activity			ovary(1)|lung(1)	2	all_cancers(97;6.64e-12)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;4.43e-40)|Epithelial(56;1.48e-39)|all cancers(56;1.49e-34)|BRCA - Breast invasive adenocarcinoma(115;0.0441)|Colorectal(110;0.055)			AGGGCCTGCTCCAGGTCCTTC	0.607			NA											21	88					0	0	0.004656	0	0
DMRT3	58524	broad.mit.edu	37	9	990869	990869	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr9:990869G>T	uc003zgw.1	+	2	1321	c.1283G>T	c.(1282-1284)CGC>CTC	p.R428L		NM_021240	NP_067063	Q9NQL9	DMRT3_HUMAN	doublesex and mab-3 related transcription factor	428					cell differentiation|multicellular organismal development|sex differentiation	nucleus	DNA binding|metal ion binding|sequence-specific DNA binding transcription factor activity	p.R428C(1)		ovary(2)|central_nervous_system(1)	3		all_lung(10;1.39e-08)|Lung NSC(10;1.42e-08)		Lung(218;0.0196)		CTTCCTGCCCGCGCCACGGAA	0.552			NA											12	14					0.00010058	0.000113736	0.001368	1	0
KIAA0020	9933	broad.mit.edu	37	9	2834129	2834129	+	Silent	SNP	T	T	C			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr9:2834129T>C	uc003zhp.1	-	4	438	c.342A>G	c.(340-342)AAA>AAG	p.K114K	KIAA0020_uc010mhc.1_Silent_p.K113K|KIAA0020_uc003zhq.1_Silent_p.K114K	NM_014878	NP_055693	Q15397	K0020_HUMAN	KIAA0020 protein	114						endoplasmic reticulum|nucleolus	RNA binding			ovary(1)	1				GBM - Glioblastoma multiforme(50;0.0319)		TCTTCTTCTTTTTGAAGTCAT	0.348			NA											7	6					0	0	0.004482	0	0
INSL4	3641	broad.mit.edu	37	9	5231714	5231714	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr9:5231714C>A	uc003ziy.2	+	1	296	c.191C>A	c.(190-192)CCC>CAC	p.P64H		NM_002195	NP_002186	Q14641	INSL4_HUMAN	insulin-like 4 precursor	64					cell proliferation|cell-cell signaling|female pregnancy|multicellular organismal development|signal transduction	extracellular space|soluble fraction	hormone activity|insulin-like growth factor receptor binding				0	all_hematologic(13;0.137)	Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.0201)|Lung(218;0.14)		TCTGGACGTCCCAAAGGTGAG	0.512			NA											11	13					0.000978159	0.00106403	0.000978	1	0
NFIB	4781	broad.mit.edu	37	9	14307439	14307439	+	Silent	SNP	T	T	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr9:14307439T>A	uc003zle.2	-	2	546	c.111A>T	c.(109-111)CGA>CGT	p.R37R	NFIB_uc003zlf.2_Silent_p.R37R|NFIB_uc011lmo.1_Silent_p.R37R	NM_005596	NP_005587	O00712	NFIB_HUMAN	nuclear factor I/B	37	CTF/NF-I.				anterior commissure morphogenesis|chondrocyte differentiation|Clara cell differentiation|commissural neuron axon guidance|DNA replication|glial cell differentiation|lung ciliated cell differentiation|negative regulation of DNA binding|negative regulation of epithelial cell proliferation involved in lung morphogenesis|negative regulation of mesenchymal cell proliferation involved in lung development|positive regulation of transcription from RNA polymerase II promoter|principal sensory nucleus of trigeminal nerve development|Type I pneumocyte differentiation|Type II pneumocyte differentiation	cerebellar mossy fiber|nucleolus|nucleus	RNA polymerase II transcription corepressor activity|sequence-specific DNA binding RNA polymerase II transcription factor activity				0				GBM - Glioblastoma multiforme(50;4.4e-08)|LUAD - Lung adenocarcinoma(58;0.119)|Lung(218;0.164)		ACTTGCGTTTTCGAGCCTGCA	0.443	Esophageal Squamous(132;921 1730 14828 40753 46471)		NA	T	MYB|HGMA2	adenoid cystic carcinoma|lipoma								16	10					0	0	0.00499	0	0
ADAMTSL1	92949	broad.mit.edu	37	9	18889718	18889718	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr9:18889718G>T	uc003zne.3	+	25	4742	c.4615G>T	c.(4615-4617)GCG>TCG	p.A1539S	ADAMTSL1_uc003znf.3_Missense_Mutation_p.A240S	NM_001040272	NP_001035362	Q8N6G6	ATL1_HUMAN	ADAMTS-like 1 isoform 4 precursor	1539						proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			ovary(3)|upper_aerodigestive_tract(1)|lung(1)	5				GBM - Glioblastoma multiforme(50;1.29e-17)		GCAGCCCATCGCGTGCAACCG	0.667			NA											3	5					2.56e-06	3.10246e-06	0.009096	1	0
MLLT3	4300	broad.mit.edu	37	9	20414338	20414338	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr9:20414338C>A	uc003zoe.2	-	5	765	c.506G>T	c.(505-507)AGC>ATC	p.S169I	MLLT3_uc011lne.1_Missense_Mutation_p.S137I|MLLT3_uc011lnf.1_Missense_Mutation_p.S166I|MLLT3_uc003zof.2_5'UTR|MLLT3_uc011lng.1_Missense_Mutation_p.A131S	NM_004529	NP_004520	P42568	AF9_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	169	Poly-Ser.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding			lung(2)|ovary(1)	3				GBM - Glioblastoma multiforme(3;4.35e-105)|Lung(42;3.48e-06)|LUSC - Lung squamous cell carcinoma(42;7.92e-05)		gctgctgctgctgctactgct	0.149			NA	T	MLL	ALL								3	8					1.23904e-05	1.44506e-05	0.000602	1	0
KIAA1797	54914	broad.mit.edu	37	9	20740332	20740332	+	Missense_Mutation	SNP	A	A	C			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr9:20740332A>C	uc003zog.1	+	7	748	c.385A>C	c.(385-387)ACC>CCC	p.T129P		NM_017794	NP_060264	Q5VW36	K1797_HUMAN	hypothetical protein LOC54914	129						integral to membrane	binding			ovary(8)|breast(1)|kidney(1)	10				GBM - Glioblastoma multiforme(3;2.1e-125)|Lung(42;2.76e-14)|LUSC - Lung squamous cell carcinoma(42;1.99e-11)		GAGTATATATACCATTAGGTA	0.274			NA											17	21					0	0	0.007413	0	0
C9orf131	138724	broad.mit.edu	37	9	35044853	35044853	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr9:35044853C>A	uc003zvw.2	+	2	2256	c.2227C>A	c.(2227-2229)CGC>AGC	p.R743S	C9orf131_uc003zvu.2_Missense_Mutation_p.R695S|C9orf131_uc003zvv.2_Missense_Mutation_p.R670S|C9orf131_uc003zvx.2_Missense_Mutation_p.R708S	NM_203299	NP_976044	Q5VYM1	CI131_HUMAN	hypothetical protein LOC138724 isoform A	743											0	all_epithelial(49;0.22)		LUSC - Lung squamous cell carcinoma(32;0.00117)|Lung(28;0.00309)			GAAGATTGAACGCACTCATCC	0.592			NA											28	35					2.09667e-21	3.52686e-21	0.003755	1	0
FOXD4L5	653427	broad.mit.edu	37	9	70177786	70177786	+	Silent	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr9:70177786C>A	uc010moc.2	-	1	1030	c.198G>T	c.(196-198)GGG>GGT	p.G66G		NM_001126334	NP_001119806	Q5VV16	FX4L5_HUMAN	forkhead box D4-like 5	66					axon extension involved in axon guidance|cartilage development|dichotomous subdivision of terminal units involved in ureteric bud branching|embryo development|enteric nervous system development|iridophore differentiation|lateral line nerve glial cell development|melanocyte differentiation|neural crest cell migration|pattern specification process|peripheral nervous system development|positive regulation of BMP signaling pathway|positive regulation of kidney development|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity|sympathetic nervous system development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding				0						GAAGCGCAACCCCGCCCCACC	0.562			NA											17	55					9.57634e-11	1.3434e-10	0.00333	1	0
TRPM6	140803	broad.mit.edu	37	9	77354770	77354770	+	Missense_Mutation	SNP	C	C	A	rs142946646		TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr9:77354770C>A	uc004ajl.1	-	34	5594	c.5356G>T	c.(5356-5358)GTC>TTC	p.V1786F	TRPM6_uc004ajk.1_Missense_Mutation_p.V1781F|TRPM6_uc010mpb.1_RNA|TRPM6_uc010mpc.1_Missense_Mutation_p.V737F|TRPM6_uc010mpd.1_Missense_Mutation_p.V619F|TRPM6_uc010mpe.1_Missense_Mutation_p.V333F|TRPM6_uc004ajj.1_Missense_Mutation_p.V742F	NM_017662	NP_060132	Q9BX84	TRPM6_HUMAN	transient receptor potential cation channel,	1786	Alpha-type protein kinase.|Cytoplasmic (Potential).				response to toxin	integral to membrane	ATP binding|calcium channel activity|metal ion binding|protein binding|protein serine/threonine kinase activity			lung(3)|stomach(2)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|skin(1)	8						CAAGTGCTGACGACTCTCATA	0.502			NA											15	33					2.61681e-11	3.72008e-11	0.00245	1	0
OSTF1	26578	broad.mit.edu	37	9	77745523	77745523	+	Silent	SNP	C	C	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr9:77745523C>T	uc004ajv.3	+	4	373	c.162C>T	c.(160-162)TCC>TCT	p.S54S	OSTF1_uc004ajw.3_Silent_p.S11S|OSTF1_uc004ajx.3_Silent_p.S57S	NM_012383	NP_036515	Q92882	OSTF1_HUMAN	osteoclast stimulating factor 1	54	SH3.				ossification|signal transduction	cytoplasm	identical protein binding			skin(1)	1						AAGGCACCTCCAAAGGCAGGA	0.383			NA											22	33					0	0	0.00632	0	0
FLJ46321	389763	broad.mit.edu	37	9	84608662	84608662	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr9:84608662C>T	uc004amn.2	+	4	3324	c.3277C>T	c.(3277-3279)CCA>TCA	p.P1093S		NM_001001670	NP_001001670	Q6ZQQ2	F75D1_HUMAN	hypothetical protein LOC389763	1093						integral to membrane					0						TCTGCCCCCGCCACACAGCAT	0.517			NA											8	22					0	0	0.004482	0	0
ZCCHC6	79670	broad.mit.edu	37	9	88938432	88938432	+	Nonsense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr9:88938432C>A	uc004aoq.2	-	13	2448	c.2233G>T	c.(2233-2235)GAA>TAA	p.E745*	ZCCHC6_uc011ltf.1_RNA|ZCCHC6_uc004aor.2_RNA|ZCCHC6_uc004aos.2_RNA|ZCCHC6_uc004aot.2_Nonsense_Mutation_p.E622*|ZCCHC6_uc004aou.2_Nonsense_Mutation_p.E745*	NM_024617	NP_078893	Q5VYS8	TUT7_HUMAN	zinc finger, CCHC domain containing 6	745					RNA 3'-end processing		nucleic acid binding|RNA uridylyltransferase activity|zinc ion binding			ovary(2)	2						CTTCCTGTTTCTGGATGGTAT	0.433			NA											38	40					5.04308e-16	7.96924e-16	0.00623	1	0
DAPK1	1612	broad.mit.edu	37	9	90255720	90255720	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr9:90255720G>C	uc004apc.2	+	9	924	c.786G>C	c.(784-786)AAG>AAC	p.K262N	DAPK1_uc004ape.2_Missense_Mutation_p.K262N|DAPK1_uc004apd.2_Missense_Mutation_p.K262N|DAPK1_uc011ltg.1_Missense_Mutation_p.K262N|DAPK1_uc011lth.1_5'UTR	NM_004938	NP_004929	P53355	DAPK1_HUMAN	death-associated protein kinase 1	262	Protein kinase.				apoptosis|induction of apoptosis by extracellular signals|intracellular protein kinase cascade	actin cytoskeleton|cytoplasm	ATP binding|calmodulin binding|protein serine/threonine kinase activity			ovary(1)|breast(1)	2						CCTCAAGGAAGAGAATGACAA	0.443			NA							Chronic_Lymphocytic_Leukemia_Familial_Clustering_of				45	76					0	0	0.00361	0	0
Unknown	0	broad.mit.edu	37	9	90745252	90745252	+	Silent	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr9:90745252G>T	uc011lti.1	-	4	2729	c.2700C>A	c.(2698-2700)CCC>CCA	p.P900P	uc004apx.1_5'Flank					SubName: Full=cDNA FLJ59639;												NA						GATGGCCCTGGGGCACTTGAG	0.552			NA											21	22					1.50039e-11	2.15148e-11	0.001882	1	0
C9orf156	51531	broad.mit.edu	37	9	100667197	100667197	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr9:100667197C>T	uc004axv.1	-	5	1221	c.1144G>A	c.(1144-1146)GAT>AAT	p.D382N	C9orf156_uc004axw.1_Missense_Mutation_p.D279N|C9orf156_uc004axx.1_Missense_Mutation_p.D236N	NM_016481	NP_057565	Q9BU70	NAP1_HUMAN	Nef associated protein 1	382					interspecies interaction between organisms		hydrolase activity				0		Acute lymphoblastic leukemia(62;0.158)				GACCGAGGATCCGCTGACAGC	0.483			NA											12	26					0	0	0.001368	0	0
COL15A1	1306	broad.mit.edu	37	9	101800987	101800987	+	Nonsense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr9:101800987C>A	uc004azb.1	+	22	2653	c.2447C>A	c.(2446-2448)TCG>TAG	p.S816*		NM_001855	NP_001846	P39059	COFA1_HUMAN	alpha 1 type XV collagen precursor	816	Nonhelical region 4 (NC4).				angiogenesis|cell differentiation|signal transduction	collagen type XV|extracellular space|integral to membrane	binding			ovary(6)	6		Acute lymphoblastic leukemia(62;0.0562)				ATGAATTTCTCGGACATTCCT	0.483			NA											25	45					2.42023e-17	3.89912e-17	0.003271	1	0
CYLC2	1539	broad.mit.edu	37	9	105767107	105767107	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr9:105767107C>A	uc004bbs.2	+	4	381	c.311C>A	c.(310-312)ACT>AAT	p.T104N		NM_001340	NP_001331	Q14093	CYLC2_HUMAN	cylicin 2	104	31 X 3 AA repeats of K-K-X.				cell differentiation|multicellular organismal development|spermatogenesis	cytoskeletal calyx	structural constituent of cytoskeleton			skin(1)	1		all_hematologic(171;0.125)				CCAACTCGTACTGTCGAGGTG	0.368			NA											4	13					0.000602214	0.00065942	0.000602	1	0
OR13F1	138805	broad.mit.edu	37	9	107267456	107267456	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr9:107267456C>G	uc011lvm.1	+	1	913	c.913C>G	c.(913-915)CTG>GTG	p.L305V		NM_001004485	NP_001004485	Q8NGS4	O13F1_HUMAN	olfactory receptor, family 13, subfamily F,	305	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(1)|ovary(1)|skin(1)	3						GAAAAAATTGCTGATTAGAAA	0.353			NA											12	24					0	0	0.001855	0	0
OR13C8	138802	broad.mit.edu	37	9	107332233	107332233	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr9:107332233C>A	uc011lvo.1	+	1	785	c.785C>A	c.(784-786)CCT>CAT	p.P262H		NM_001004483	NP_001004483	Q8NGS7	O13C8_HUMAN	olfactory receptor, family 13, subfamily C,	262	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						TACGCAAAGCCTGAGTCTAAA	0.458			NA											12	26					6.40141e-05	7.28859e-05	0.000978	1	0
EPB41L4B	54566	broad.mit.edu	37	9	112018505	112018505	+	Splice_Site	SNP	C	C	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr9:112018505C>T	uc004bdz.1	-	9	1136	c.841_splice	c.e9-1	p.G281_splice	EPB41L4B_uc004bea.2_Splice_Site_p.G281_splice	NM_019114	NP_061987	Q9H329	E41LB_HUMAN	erythrocyte membrane protein band 4.1 like 4B							cytoplasm|cytoskeleton|extrinsic to membrane	cytoskeletal protein binding|structural constituent of cytoskeleton			ovary(1)|central_nervous_system(1)|skin(1)	3						CATCTCTTCCCTACAAACAAA	0.393			NA											22	30					0	0	0.003954	0	0
DAB2IP	153090	broad.mit.edu	37	9	124534959	124534959	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr9:124534959G>T	uc004bln.2	+	12	2137	c.2068G>T	c.(2068-2070)GGG>TGG	p.G690W	DAB2IP_uc004blo.2_Missense_Mutation_p.G594W|DAB2IP_uc004blp.2_Missense_Mutation_p.G123W	NM_032552	NP_115941	Q5VWQ8	DAB2P_HUMAN	disabled homolog 2 interacting protein isoform	718					activation of JUN kinase activity|apoptosis in response to endoplasmic reticulum stress|cellular response to epidermal growth factor stimulus|cellular response to tumor necrosis factor|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of catenin import into nucleus|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of epithelial cell migration|negative regulation of epithelial cell proliferation|negative regulation of epithelial to mesenchymal transition|negative regulation of fibroblast proliferation|negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of MAP kinase activity|negative regulation of NF-kappaB transcription factor activity|negative regulation of Ras GTPase activity|negative regulation of transcription from RNA polymerase II promoter|positive regulation of apoptosis|positive regulation of transcription from RNA polymerase II promoter	cytoplasm|intrinsic to internal side of plasma membrane	14-3-3 protein binding|death receptor binding|mitogen-activated protein kinase kinase kinase binding|protein homodimerization activity|protein phosphatase 2A binding|Ras GTPase activator activity|signaling adaptor activity			ovary(1)|central_nervous_system(1)	2						AAGGTCCTCCGGGGTCCAGCC	0.567			NA											21	33					1.50039e-11	2.15148e-11	0.001882	1	0
LHX6	26468	broad.mit.edu	37	9	124976561	124976561	+	Splice_Site	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr9:124976561C>A	uc010mvw.2	-	5	805	c.696_splice	c.e5+1	p.Q232_splice	LHX6_uc004blx.3_Splice_Site_p.Q261_splice|LHX6_uc004bly.3_Splice_Site_p.Q261_splice	NM_014368	NP_055183	Q9UPM6	LHX6_HUMAN	LIM homeobox protein 6 isoform 1						cell maturation|cerebral cortex GABAergic interneuron migration|cerebral cortex radially oriented cell migration|cerebral cortex tangential migration	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0						TGCAGCGGTACCTGCAGCTGT	0.602			NA											7	15					0.000442599	0.000487515	0.006214	1	0
CRB2	286204	broad.mit.edu	37	9	126125366	126125366	+	Missense_Mutation	SNP	A	A	C			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr9:126125366A>C	uc004bnx.1	+	2	409	c.317A>C	c.(316-318)GAG>GCG	p.E106A	CRB2_uc004bnw.1_Missense_Mutation_p.E106A	NM_173689	NP_775960	Q5IJ48	CRUM2_HUMAN	crumbs homolog 2 precursor	106	Extracellular (Potential).|EGF-like 1.					extracellular region|integral to membrane|plasma membrane	calcium ion binding			ovary(1)	1						CCACGCTGCGAGCTGGACATC	0.672			NA											11	9					0	0	0.001368	0	0
ZNF79	7633	broad.mit.edu	37	9	130207408	130207408	+	Nonsense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr9:130207408G>T	uc004bqw.3	+	5	1843	c.1429G>T	c.(1429-1431)GAG>TAG	p.E477*	ZNF79_uc011maf.1_Nonsense_Mutation_p.E453*|ZNF79_uc011mag.1_Nonsense_Mutation_p.E453*	NM_007135	NP_009066	Q15937	ZNF79_HUMAN	zinc finger protein 79	477	C2H2-type 11.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)	1						CGAATGCAGCGAGTGTGGGAA	0.517			NA											41	82					8.94452e-30	1.58339e-29	0.00361	1	0
SARDH	1757	broad.mit.edu	37	9	136595228	136595228	+	Nonsense_Mutation	SNP	G	G	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr9:136595228G>A	uc004cep.3	-	5	906	c.772C>T	c.(772-774)CAG>TAG	p.Q258*	SARDH_uc004ceo.2_Nonsense_Mutation_p.Q258*|SARDH_uc011mdn.1_Nonsense_Mutation_p.Q258*|SARDH_uc011mdo.1_Nonsense_Mutation_p.Q90*	NM_001134707	NP_001128179	Q9UL12	SARDH_HUMAN	sarcosine dehydrogenase precursor	258					glycine catabolic process	mitochondrial matrix	aminomethyltransferase activity|sarcosine dehydrogenase activity				0				OV - Ovarian serous cystadenocarcinoma(145;3.21e-07)|Epithelial(140;2.37e-06)|all cancers(34;2.75e-05)		GAACCATGCTGAGTCTCCACA	0.582			NA											20	34					0	0	0.001882	0	0
MXRA5	25878	broad.mit.edu	37	X	3239345	3239345	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chrX:3239345C>G	uc004crg.3	-	5	4538	c.4381G>C	c.(4381-4383)GAT>CAT	p.D1461H		NM_015419	NP_056234	Q9NR99	MXRA5_HUMAN	adlican precursor	1461						extracellular region				ovary(5)|lung(1)|central_nervous_system(1)|skin(1)	8		all_lung(23;0.00031)|Lung NSC(23;0.000946)				TGATCTTGATCAAGGGTGGTG	0.493			NA											9	6					0	0	0.004482	0	0
MSL3	10943	broad.mit.edu	37	X	11790778	11790778	+	Nonsense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chrX:11790778G>T	uc004cuw.2	+	12	1525	c.1420G>T	c.(1420-1422)GAG>TAG	p.E474*	MSL3_uc004cux.2_Nonsense_Mutation_p.E415*|MSL3_uc011mig.1_Nonsense_Mutation_p.E325*|MSL3_uc011mih.1_Nonsense_Mutation_p.E462*|MSL3_uc004cuy.2_Nonsense_Mutation_p.E308*	NM_078629	NP_523353	Q8N5Y2	MS3L1_HUMAN	male-specific lethal 3-like 1 isoform a	474					histone H4-K16 acetylation|multicellular organismal development|transcription from RNA polymerase II promoter	MSL complex	DNA binding|methylated histone residue binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1						GTCCTTTTCTGAGAAGAATCT	0.333			NA											7	8					0.000274275	0.000304364	0.004482	1	0
GLRA2	2742	broad.mit.edu	37	X	14622519	14622519	+	Missense_Mutation	SNP	T	T	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chrX:14622519T>A	uc010nep.2	+	6	909	c.577T>A	c.(577-579)TTT>ATT	p.F193I	GLRA2_uc010neq.2_Missense_Mutation_p.F193I|GLRA2_uc004cwe.3_Missense_Mutation_p.F193I|GLRA2_uc011mio.1_Missense_Mutation_p.F104I|GLRA2_uc011mip.1_Missense_Mutation_p.F171I	NM_001118885	NP_001112357	P23416	GLRA2_HUMAN	glycine receptor, alpha 2 isoform A	193	Extracellular (Probable).				neuropeptide signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	extracellular-glycine-gated chloride channel activity|glycine binding|receptor activity|transmitter-gated ion channel activity			ovary(1)|lung(1)	2	Hepatocellular(33;0.128)				Ethanol(DB00898)|Glycine(DB00145)	GCTGGAGAGTTGTAAGTCACC	0.418			NA											34	20					0	0	0.005524	0	0
ZNF645	158506	broad.mit.edu	37	X	22291500	22291500	+	Missense_Mutation	SNP	A	A	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chrX:22291500A>T	uc004dai.1	+	1	441	c.392A>T	c.(391-393)CAG>CTG	p.Q131L		NM_152577	NP_689790	Q8N7E2	ZN645_HUMAN	zinc finger protein 645	131	C2H2-type.					intracellular	zinc ion binding			lung(1)|pancreas(1)	2						AAAAGCTTACAGGCTCATATC	0.443			NA											15	14					0	0	0.00499	0	0
MAGEB6	158809	broad.mit.edu	37	X	26212975	26212975	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chrX:26212975C>A	uc004dbr.2	+	2	1161	c.1012C>A	c.(1012-1014)CAA>AAA	p.Q338K	MAGEB6_uc010ngc.1_Missense_Mutation_p.Q118K	NM_173523	NP_775794	Q8N7X4	MAGB6_HUMAN	melanoma antigen family B, 6	338	MAGE.									ovary(3)	3						AGATTTGGTGCAAGATAAGTA	0.498			NA											37	30					9.72345e-25	1.68517e-24	0.00361	1	0
FAM47A	158724	broad.mit.edu	37	X	34148498	34148498	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chrX:34148498G>T	uc004ddg.2	-	1	1931	c.1898C>A	c.(1897-1899)CCC>CAC	p.P633H		NM_203408	NP_981953	Q5JRC9	FA47A_HUMAN	hypothetical protein LOC158724	633										ovary(4)|central_nervous_system(1)	5						TCTGTACTTGGGGGTAAAGTC	0.443			NA											17	16					3.52763e-06	4.24057e-06	0.00499	1	0
SYTL5	94122	broad.mit.edu	37	X	37965997	37965997	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chrX:37965997G>T	uc004ddu.2	+	12	1841	c.1307G>T	c.(1306-1308)GGA>GTA	p.G436V	SYTL5_uc004ddv.2_Missense_Mutation_p.G436V|SYTL5_uc004ddx.2_Missense_Mutation_p.G458V	NM_001163335	NP_001156807	Q8TDW5	SYTL5_HUMAN	synaptotagmin-like 5 isoform 1	436	C2 1.				intracellular protein transport	membrane	metal ion binding|Rab GTPase binding			skin(1)	1						CTGGCCATAGGAGATGAAAAG	0.408			NA											8	15					5.18039e-06	6.18734e-06	0.00308	1	0
ZNF81	347344	broad.mit.edu	37	X	47775276	47775277	+	Missense_Mutation	DNP	GA	GA	TG			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	GA	GA	-	-	GA	GA	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chrX:47775276_47775277GA>TG	uc010nhy.1	+	6	1599_1600	c.1231_1232GA>TG	c.(1231-1233)GAG>TGG	p.E411W		NM_007137	NP_009068	P51508	ZNF81_HUMAN	zinc finger protein 81	411						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		all_lung(315;0.0973)				TCACACTGGAGAGAGACATCAC	0.421			NA											10	8					0	0	0.004672	0	0
CCNB3	85417	broad.mit.edu	37	X	50094343	50094343	+	Missense_Mutation	SNP	A	A	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chrX:50094343A>T	uc004dox.3	+	12	4362	c.4064A>T	c.(4063-4065)AAG>ATG	p.K1355M	CCNB3_uc004doy.2_Missense_Mutation_p.K1355M|CCNB3_uc004doz.2_Missense_Mutation_p.K251M|CCNB3_uc010njq.2_Missense_Mutation_p.K247M|CCNB3_uc004dpa.2_Missense_Mutation_p.K194M	NM_033031	NP_149020	Q8WWL7	CCNB3_HUMAN	cyclin B3 isoform 3	1355					cell division|meiosis|regulation of cyclin-dependent protein kinase activity|regulation of G2/M transition of mitotic cell cycle	nucleus	protein kinase binding			ovary(4)|lung(3)|large_intestine(1)|pancreas(1)	9	Ovarian(276;0.236)					GATAGTCTCAAGGCTGTGTAT	0.458			NA											58	48					0	0	0.00361	0	0
SHROOM4	57477	broad.mit.edu	37	X	50377003	50377003	+	Silent	SNP	C	C	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chrX:50377003C>T	uc004dpe.2	-	4	2096	c.2070G>A	c.(2068-2070)AGG>AGA	p.R690R	SHROOM4_uc004dpd.3_RNA|SHROOM4_uc004dpf.1_Silent_p.R574R	NM_020717	NP_065768	Q9ULL8	SHRM4_HUMAN	shroom family member 4	690					actin filament organization|brain development|cell morphogenesis|cognition	apical plasma membrane|basal plasma membrane|internal side of plasma membrane|nucleus	actin filament binding			upper_aerodigestive_tract(1)	1	Ovarian(276;0.236)					ACTGGCCAGGCCTCTGGCCAG	0.582			NA											6	7					0	0	0.001168	0	0
SMC1A	8243	broad.mit.edu	37	X	53439185	53439185	+	Silent	SNP	C	C	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chrX:53439185C>T	uc004dsg.2	-	6	942	c.873G>A	c.(871-873)TTG>TTA	p.L291L	SMC1A_uc011moe.1_Silent_p.L269L|SMC1A_uc011mof.1_Intron	NM_006306	NP_006297	Q14683	SMC1A_HUMAN	structural maintenance of chromosomes 1A	291	Potential.				cell cycle checkpoint|cell division|DNA repair|meiosis|mitotic metaphase/anaphase transition|mitotic prometaphase|mitotic sister chromatid cohesion|mitotic spindle organization|negative regulation of DNA endoreduplication|nuclear mRNA splicing, via spliceosome|response to radiation|signal transduction in response to DNA damage	cohesin core heterodimer|condensed chromosome kinetochore|condensed nuclear chromosome|cytoplasm|meiotic cohesin complex|nucleoplasm	ATP binding|chromatin binding|microtubule motor activity|protein heterodimerization activity			ovary(5)|central_nervous_system(1)	6						GCTTCTGGTTCAATTCTGAGT	0.512			NA											6	11					0	0	0.00308	0	0
MTMR8	55613	broad.mit.edu	37	X	63444721	63444721	+	Silent	SNP	C	C	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chrX:63444721C>T	uc011mou.1	-	10	2003	c.1935G>A	c.(1933-1935)CTG>CTA	p.L645L	ASB12_uc004dvp.1_Silent_p.L261L|ASB12_uc004dvq.1_Silent_p.L270L|ASB12_uc004dvr.1_Silent_p.L270L	NM_017677	NP_060147	Q96EF0	MTMR8_HUMAN	myotubularin related protein 8	Error:Variant_position_missing_in_Q96EF0_after_alignment						nuclear envelope	protein tyrosine phosphatase activity			ovary(2)|breast(2)	4						GGGCCTGTAGCAGCAATGCAA	0.502			NA											13	12					0	0	0.008871	0	0
ZC3H12B	340554	broad.mit.edu	37	X	64709138	64709138	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chrX:64709138G>A	uc010nko.2	+	1	433	c.424G>A	c.(424-426)GAT>AAT	p.D142N		NM_001010888	NP_001010888	Q5HYM0	ZC12B_HUMAN	zinc finger CCCH-type containing 12B	142							endonuclease activity|nucleic acid binding|zinc ion binding			lung(1)|kidney(1)|pancreas(1)	3						GAACAAAGGTGATTCAGAAGG	0.448			NA											23	18					0	0	0.004656	0	0
SLC7A3	84889	broad.mit.edu	37	X	70148374	70148374	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chrX:70148374G>T	uc004dyn.2	-	4	797	c.639C>A	c.(637-639)GAC>GAA	p.D213E	SLC7A3_uc004dyo.2_Missense_Mutation_p.D213E	NM_032803	NP_116192	Q8WY07	CTR3_HUMAN	solute carrier family 7 (cationic amino acid	213	Extracellular (Potential).				cellular nitrogen compound metabolic process	integral to membrane|plasma membrane				ovary(1)|kidney(1)	2	Renal(35;0.156)				L-Arginine(DB00125)|L-Lysine(DB00123)|L-Ornithine(DB00129)	AGTTGTGCACGTCCCCCTTAA	0.517			NA											6	2					8.12818e-05	9.21236e-05	0.001984	1	0
MED12	9968	broad.mit.edu	37	X	70343028	70343028	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chrX:70343028G>T	uc004dyy.2	+	11	1768	c.1569G>T	c.(1567-1569)ATG>ATT	p.M523I	MED12_uc011mpq.1_Missense_Mutation_p.M523I|MED12_uc004dyz.2_Missense_Mutation_p.M523I|MED12_uc004dza.2_Missense_Mutation_p.M370I	NM_005120	NP_005111	Q93074	MED12_HUMAN	mediator complex subunit 12	523					androgen receptor signaling pathway|negative regulation of Wnt receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|protein C-terminus binding|protein domain specific binding|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	4	Renal(35;0.156)					ATCGTGCTATGGTGGTAGCCA	0.502			NA											24	13					3.28513e-13	4.90953e-13	0.003954	1	0
MED12	9968	broad.mit.edu	37	X	70345907	70345907	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chrX:70345907G>T	uc004dyy.2	+	18	2643	c.2444G>T	c.(2443-2445)CGG>CTG	p.R815L	MED12_uc011mpq.1_Missense_Mutation_p.R815L|MED12_uc004dyz.2_Missense_Mutation_p.R815L|MED12_uc004dza.2_Missense_Mutation_p.R662L	NM_005120	NP_005111	Q93074	MED12_HUMAN	mediator complex subunit 12	815					androgen receptor signaling pathway|negative regulation of Wnt receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|protein C-terminus binding|protein domain specific binding|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	4	Renal(35;0.156)					GGGCAGAAGCGGCGACGCAAC	0.552			NA											52	40					3.28156e-27	5.7816e-27	0.00361	1	0
CYSLTR1	10800	broad.mit.edu	37	X	77528533	77528533	+	Silent	SNP	G	G	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chrX:77528533G>A	uc004edb.2	-	3	1111	c.711C>T	c.(709-711)GTC>GTT	p.V237V	CYSLTR1_uc010nma.2_Silent_p.V237V|CYSLTR1_uc010nmb.2_Silent_p.V237V	NM_006639	NP_006630	Q9Y271	CLTR1_HUMAN	cysteinyl leukotriene receptor 1	237	Helical; Name=6; (Potential).				elevation of cytosolic calcium ion concentration|respiratory gaseous exchange	integral to plasma membrane|membrane fraction	leukotriene receptor activity			ovary(1)	1					Amlexanox(DB01025)|Cinalukast(DB00587)|Montelukast(DB00471)|Nedocromil(DB00716)|Pranlukast(DB01411)|Zafirlukast(DB00549)	CAGCGGTCACGACCATGATCA	0.333			NA											16	11					0	0	0.00499	0	0
DACH2	117154	broad.mit.edu	37	X	86067905	86067905	+	Silent	SNP	G	G	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chrX:86067905G>A	uc004eew.2	+	8	1457	c.1287G>A	c.(1285-1287)AAG>AAA	p.K429K	DACH2_uc004eex.2_Silent_p.K416K|DACH2_uc010nmq.2_Silent_p.K295K|DACH2_uc011mra.1_Silent_p.K262K|DACH2_uc010nmr.2_Silent_p.K210K|DACH2_uc004eey.2_Silent_p.K112K|DACH2_uc004eez.2_Silent_p.K112K	NM_053281	NP_444511	Q96NX9	DACH2_HUMAN	dachshund 2 isoform a	429					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|nucleotide binding			ovary(4)|pancreas(1)	5						CCTTGGACAAGATACAGCTGA	0.443			NA											18	6					0	0	0.001882	0	0
SYTL4	94121	broad.mit.edu	37	X	99955908	99955908	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chrX:99955908C>A	uc004egd.3	-	7	880	c.524G>T	c.(523-525)CGG>CTG	p.R175L	SYTL4_uc010nnc.2_Missense_Mutation_p.R175L|SYTL4_uc004ege.3_Missense_Mutation_p.R175L|SYTL4_uc004egf.3_Missense_Mutation_p.R175L|SYTL4_uc004egg.3_Missense_Mutation_p.R175L	NM_080737	NP_542775	Q96C24	SYTL4_HUMAN	synaptotagmin-like 4	175					exocytosis|intracellular protein transport	extrinsic to membrane|plasma membrane|synaptic vesicle|transport vesicle membrane	neurexin binding|phospholipid binding|Rab GTPase binding|transporter activity|zinc ion binding			ovary(2)	2					Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	CTCCTTCTGCCGCTCCTGAAT	0.373			NA											20	23					6.32553e-13	9.41548e-13	0.004656	1	0
XKRX	402415	broad.mit.edu	37	X	100178007	100178007	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chrX:100178007C>G	uc004egn.2	-	2	984	c.379G>C	c.(379-381)GAG>CAG	p.E127Q	XKRX_uc011mre.1_Intron	NM_212559	NP_997724	Q6PP77	XKR2_HUMAN	XK, Kell blood group complex subunit-related,	127						integral to membrane|plasma membrane				breast(1)	1						TCCTGCTCCTCTTTCTTCCAC	0.507			NA											17	23					0	0	0.010504	0	0
BTK	695	broad.mit.edu	37	X	100615557	100615557	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chrX:100615557C>A	uc004ehg.2	-	8	968	c.775G>T	c.(775-777)GGG>TGG	p.G259W	BTK_uc004ehf.2_5'Flank|BTK_uc010nnh.2_5'Flank|BTK_uc010nni.2_5'Flank|BTK_uc004ehe.2_5'Flank|BTK_uc010nnj.2_5'Flank|BTK_uc010nnk.2_5'Flank|BTK_uc010nnl.2_5'Flank|BTK_uc010nnm.2_5'Flank|BTK_uc010nnn.2_Missense_Mutation_p.G259W|BTK_uc010nno.2_Missense_Mutation_p.G293W|BTK_uc004ehh.1_5'Flank|BTK_uc004ehi.2_Missense_Mutation_p.G259W	NM_000061	NP_000052	Q06187	BTK_HUMAN	Bruton agammaglobulinemia tyrosine kinase	259	SH3.				calcium-mediated signaling|induction of apoptosis by extracellular signals|mesoderm development	cytosol|membrane raft|nucleus|plasma membrane	ATP binding|identical protein binding|metal ion binding|non-membrane spanning protein tyrosine kinase activity|phosphatidylinositol-3,4,5-trisphosphate binding			lung(3)|central_nervous_system(2)|ovary(1)	6						TGGACTCACCCATTTTTATCT	0.498			NA							Agammaglobulinemia_X-linked				15	15					1.33834e-09	1.82244e-09	0.007413	1	0
MCART6	401612	broad.mit.edu	37	X	103349077	103349077	+	Silent	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chrX:103349077C>A	uc004elu.2	-	2	1045	c.864G>T	c.(862-864)ACG>ACT	p.T288T		NM_001012755	NP_001012773	Q5H9E4	MCAR6_HUMAN	mitochondrial carrier triple repeat 6	288	Solcar 3.|Helical; Name=6; (Potential).				transport	integral to membrane|mitochondrial inner membrane					0						CATGGATTGCCGTAGTGAGGC	0.532			NA											4	12					0.000602214	0.00065942	0.000602	1	0
SERPINA7	6906	broad.mit.edu	37	X	105280605	105280605	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chrX:105280605C>G	uc004eme.1	-	1	461	c.445G>C	c.(445-447)GAT>CAT	p.D149H	SERPINA7_uc010npd.2_Missense_Mutation_p.D149H|SERPINA7_uc010npe.1_Missense_Mutation_p.D149H	NM_000354	NP_000345	P05543	THBG_HUMAN	serine (or cysteine) proteinase inhibitor, clade	149					regulation of proteolysis	extracellular space	serine-type endopeptidase inhibitor activity				0					Levothyroxine(DB00451)|Liothyronine(DB00279)	GTCTTGACATCATTCAAGAAC	0.428			NA											22	38					0	0	0.003954	0	0
ALG13	79868	broad.mit.edu	37	X	110970074	110970074	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chrX:110970074G>T	uc011msy.1	+	16	1801	c.1767G>T	c.(1765-1767)ATG>ATT	p.M589I	ALG13_uc011msx.1_Missense_Mutation_p.M485I|ALG13_uc011msz.1_Missense_Mutation_p.M511I|ALG13_uc011mta.1_Missense_Mutation_p.M485I|ALG13_uc011mtb.1_Missense_Mutation_p.M485I			Q9NP73	ALG13_HUMAN	SubName: Full=Asparagine-linked glycosylation 13 homolog (S. cerevisiae);	589					dolichol-linked oligosaccharide biosynthetic process|lipid glycosylation|post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane	carbohydrate binding|N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity			lung(1)	1						AGAAGAAGATGTTCAAGAAAA	0.443			NA											14	28					0.00498961	0.00526582	0.00499	1	0
TRPC5	7224	broad.mit.edu	37	X	111195569	111195569	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chrX:111195569G>C	uc004epl.1	-	2	999	c.80C>G	c.(79-81)ACA>AGA	p.T27R	TRPC5_uc004epm.1_Missense_Mutation_p.T27R	NM_012471	NP_036603	Q9UL62	TRPC5_HUMAN	transient receptor potential cation channel,	27	Cytoplasmic (Potential).				axon guidance	calcium channel complex|integral to plasma membrane	protein binding|store-operated calcium channel activity			urinary_tract(1)	1						AGAGAGCTCTGTCTCAGCCCT	0.507			NA											11	15					0	0	0.001368	0	0
HTR2C	3358	broad.mit.edu	37	X	114141351	114141351	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chrX:114141351C>A	uc004epu.1	+	6	1478	c.750C>A	c.(748-750)CAC>CAA	p.H250Q	HTR2C_uc010nqc.1_Missense_Mutation_p.H250Q|HTR2C_uc004epv.1_Silent_p.R219R	NM_000868	NP_000859	P28335	5HT2C_HUMAN	5-hydroxytryptamine (serotonin) receptor 2C	250	Cytoplasmic (By similarity).				cGMP biosynthetic process|ERK1 and ERK2 cascade|feeding behavior|phosphatidylinositol biosynthetic process|release of sequestered calcium ion into cytosol|response to drug|synaptic transmission	cytoplasm|integral to membrane|nucleus|plasma membrane	1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding|drug binding|phosphatidylinositol phospholipase C activity|protein binding|serotonin binding|serotonin receptor activity			ovary(3)	3					Chlorprothixene(DB01239)|Clozapine(DB00363)|Dexfenfluramine(DB01191)|Fenfluramine(DB00574)|Methysergide(DB00247)|Mianserin(DB06148)|Minaprine(DB00805)|Mirtazapine(DB00370)|Olanzapine(DB00334)|Promazine(DB00420)|Propiomazine(DB00777)|Quetiapine(DB01224)|Sertindole(DB06144)|Thiethylperazine(DB00372)|Tramadol(DB00193)|Ziprasidone(DB00246)	TGTTACTGCACGGCCACACCG	0.512			NA											54	60					6.3091e-27	1.11025e-26	0.00361	1	0
DOCK11	139818	broad.mit.edu	37	X	117786007	117786007	+	Silent	SNP	C	C	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chrX:117786007C>T	uc004eqp.2	+	42	4725	c.4662C>T	c.(4660-4662)ATC>ATT	p.I1554I	DOCK11_uc004eqq.2_Silent_p.I1333I	NM_144658	NP_653259	Q5JSL3	DOC11_HUMAN	dedicator of cytokinesis 11	1554	DHR-2.				blood coagulation	cytosol	GTP binding			ovary(3)	3						TATTCATTATCAATAATTTTG	0.338			NA											5	11					0	0	0.000602	0	0
DCAF12L2	340578	broad.mit.edu	37	X	125298782	125298782	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chrX:125298782C>A	uc004euk.1	-	1	1153	c.1126G>T	c.(1126-1128)GAC>TAC	p.D376Y		NM_001013628	NP_001013650	Q5VW00	DC122_HUMAN	DDB1 and CUL4 associated factor 12-like 2	376	WD 4.									lung(2)|skin(2)|large_intestine(1)|pancreas(1)|ovary(1)	7						GCGCGGATGTCATAGAAGAGC	0.647			NA											12	25					1.3612e-06	1.67559e-06	0.003163	1	0
BCORL1	63035	broad.mit.edu	37	X	129173179	129173179	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chrX:129173179G>T	uc004evb.1	+	10	4654	c.4540G>T	c.(4540-4542)GAT>TAT	p.D1514Y	BCORL1_uc004evc.1_Missense_Mutation_p.D350Y	NM_021946	NP_068765	Q5H9F3	BCORL_HUMAN	BCL6 co-repressor-like 1	1514	ANK 2.				chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus				ovary(4)|breast(2)|lung(1)	7						CTATGGGGCCGATCCCACACT	0.567			NA											13	19					0.000219431	0.000246632	0.00245	1	0
ZNF280C	55609	broad.mit.edu	37	X	129354419	129354419	+	Silent	SNP	T	T	G			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chrX:129354419T>G	uc004evm.2	-	13	1585	c.1431A>C	c.(1429-1431)CTA>CTC	p.L477L	ZNF280C_uc010nrf.1_Silent_p.L428L	NM_017666	NP_060136	Q8ND82	Z280C_HUMAN	zinc finger protein 280C	477	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(2)|ovary(1)	3						TCAAAAATTGTAGTCTGCATT	0.388			NA											13	23					0	0	0.001855	0	0
AFF2	2334	broad.mit.edu	37	X	148037342	148037342	+	Silent	SNP	C	C	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chrX:148037342C>A	uc004fcp.2	+	11	2246	c.1767C>A	c.(1765-1767)CTC>CTA	p.L589L	AFF2_uc004fcq.2_Silent_p.L579L|AFF2_uc004fcr.2_Silent_p.L550L|AFF2_uc011mxb.1_Silent_p.L554L|AFF2_uc004fcs.2_Silent_p.L556L|AFF2_uc011mxc.1_Silent_p.L230L	NM_002025	NP_002016	P51816	AFF2_HUMAN	fragile X mental retardation 2	589					brain development|mRNA processing|regulation of RNA splicing|RNA splicing	nuclear speck	G-quadruplex RNA binding|protein binding			ovary(3)|pancreas(2)	5	Acute lymphoblastic leukemia(192;6.56e-05)					GGCCTCTCCTCAGTCTCATTA	0.483			NA											29	31					2.12542e-12	3.1323e-12	0.00632	1	0
MAGEA5	4104	broad.mit.edu	37	X	151283837	151283837	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chrX:151283837G>A	uc004ffj.2	-	3	381	c.176C>T	c.(175-177)CCA>CTA	p.P59L		NM_021049	NP_066387	P43359	MAGA5_HUMAN	melanoma antigen family A, 5	59	MAGE.										0	Acute lymphoblastic leukemia(192;6.56e-05)					GAGAGGACCTGGTGACCCAGC	0.612			NA											28	12					0	0	0.003271	0	0
RENBP	5973	broad.mit.edu	37	X	153205581	153205581	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chrX:153205581G>T	uc004fjo.1	-	9	1221	c.1051C>A	c.(1051-1053)CAA>AAA	p.Q351K		NM_002910	NP_002901	P51606	RENBP_HUMAN	renin binding protein	351					mannose metabolic process|regulation of blood pressure		endopeptidase inhibitor activity|mannose-6-phosphate isomerase activity|N-acylglucosamine 2-epimerase activity			ovary(1)|pancreas(1)	2	all_cancers(53;6.72e-15)|all_epithelial(53;3.19e-09)|all_lung(58;3.39e-06)|all_hematologic(71;4.25e-06)|Lung NSC(58;4.7e-06)|Acute lymphoblastic leukemia(192;6.56e-05)				N-Acetyl-D-glucosamine(DB00141)	TCAGCCACTTGGTAGAAGAGG	0.607			NA											21	18					1.10513e-12	1.63842e-12	0.002299	1	0
OR2T3	343173	broad.mit.edu	37	1	248637461	248637461	+	Frame_Shift_Del	DEL	C	C	-			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr1:248637461delC	uc001iel.1	+	1	810	c.810delC	c.(808-810)TACfs	p.Y270fs		NM_001005495	NP_001005495	Q8NH03	OR2T3_HUMAN	olfactory receptor, family 2, subfamily T,	270	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			CGAGTTCCTACCACACAGCTG	0.542			NA											102	275	---	---	---	---	NA	NA	NA	NA	NA
UCN3	114131	broad.mit.edu	37	10	5416097	5416098	+	Frame_Shift_Ins	INS	-	-	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr10:5416097_5416098insA	uc001ihx.1	+	2	638_639	c.414_415insA	c.(412-417)GCCAAGfs	p.A138fs		NM_053049	NP_444277	Q969E3	UCN3_HUMAN	urocortin 3 preproprotein	138_139						extracellular region	hormone activity				0						TCAACATCGCCAAGGCCAAGAA	0.574			NA											16	43	---	---	---	---	NA	NA	NA	NA	NA
HMX2	3167	broad.mit.edu	37	10	124909434	124909434	+	Frame_Shift_Del	DEL	G	G	-			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr10:124909434delG	uc001lhc.1	+	2	874	c.617delG	c.(616-618)CGGfs	p.R206fs		NM_005519	NP_005510	A2RU54	HMX2_HUMAN	H6 family homeobox 2	206	Homeobox.				cell differentiation	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0		all_neural(114;0.169)|Colorectal(57;0.207)|Glioma(114;0.222)		Colorectal(40;0.123)|COAD - Colon adenocarcinoma(40;0.141)		AAGTGGAAGCGGCAGCTCTCG	0.662			NA											5	9	---	---	---	---	NA	NA	NA	NA	NA
RBMXL2	27288	broad.mit.edu	37	11	7110371	7110372	+	Frame_Shift_Ins	INS	-	-	G			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr11:7110371_7110372insG	uc001mfc.2	+	1	207_208	c.20_21insG	c.(19-21)CCGfs	p.P7fs		NM_014469	NP_055284	O75526	HNRGT_HUMAN	testes-specific heterogenous nuclear	7						nucleus|ribonucleoprotein complex	nucleotide binding|RNA binding				0				Epithelial(150;5.14e-08)|BRCA - Breast invasive adenocarcinoma(625;0.189)		GCGGATCGCCCGGGGAAGCTGT	0.634			NA											8	25	---	---	---	---	NA	NA	NA	NA	NA
CWF19L2	143884	broad.mit.edu	37	11	107224297	107224297	+	Frame_Shift_Del	DEL	C	C	-			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr11:107224297delC	uc010rvp.1	-	13	2068	c.2038delG	c.(2038-2040)GACfs	p.D680fs	CWF19L2_uc001pjh.3_RNA|CWF19L2_uc009yxo.2_RNA	NM_152434	NP_689647	Q2TBE0	C19L2_HUMAN	CWF19-like 2, cell cycle control	680							catalytic activity				0		Melanoma(852;1.75e-05)|all_epithelial(67;6.27e-05)|Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0017)|Breast(348;0.0258)		Epithelial(105;7.18e-06)|BRCA - Breast invasive adenocarcinoma(274;1.65e-05)|all cancers(92;1.76e-05)		TGAGAGCTGTCAAAACAATAC	0.363			NA											12	21	---	---	---	---	NA	NA	NA	NA	NA
PHLDB1	23187	broad.mit.edu	37	11	118498054	118498054	+	Frame_Shift_Del	DEL	C	C	-			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr11:118498054delC	uc001ptr.1	+	7	868	c.515delC	c.(514-516)ACCfs	p.T172fs	PHLDB1_uc010ryh.1_Frame_Shift_Del_p.T171fs|PHLDB1_uc001pts.2_Frame_Shift_Del_p.T172fs|PHLDB1_uc001ptt.2_Frame_Shift_Del_p.T172fs|PHLDB1_uc001ptu.1_RNA|PHLDB1_uc001ptv.1_5'UTR|PHLDB1_uc001ptw.1_5'Flank	NM_015157	NP_055972	Q86UU1	PHLB1_HUMAN	pleckstrin homology-like domain, family B,	172											0	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0523)|all_hematologic(192;0.0735)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;3.4e-05)		GGGAACCACACCCCACAGACT	0.522			NA											20	40	---	---	---	---	NA	NA	NA	NA	NA
SLC6A15	55117	broad.mit.edu	37	12	85279297	85279298	+	Frame_Shift_Ins	INS	-	-	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr12:85279297_85279298insA	uc001szv.2	-	4	983_984	c.490_491insT	c.(490-492)TGGfs	p.W164fs	SLC6A15_uc010sul.1_Frame_Shift_Ins_p.W57fs|SLC6A15_uc001szy.2_Frame_Shift_Ins_p.W164fs	NM_182767	NP_877499	Q9H2J7	S6A15_HUMAN	solute carrier family 6, member 15 isoform 1	164	Extracellular (Potential).				cellular nitrogen compound metabolic process|leucine transport|proline transport	integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity			pancreas(2)|ovary(1)	3						AAACAAACTCCAGCCAATGATG	0.366			NA											11	44	---	---	---	---	NA	NA	NA	NA	NA
MMP17	4326	broad.mit.edu	37	12	132335720	132335720	+	Frame_Shift_Del	DEL	G	G	-			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr12:132335720delG	uc001ujc.1	+	10	1812	c.1713delG	c.(1711-1713)CCGfs	p.P571fs	MMP17_uc001ujd.1_Frame_Shift_Del_p.P487fs	NM_016155	NP_057239	Q9ULZ9	MMP17_HUMAN	matrix metalloproteinase 17 preproprotein	571					proteolysis	anchored to membrane|integral to plasma membrane|proteinaceous extracellular matrix	calcium ion binding|enzyme activator activity|metalloendopeptidase activity|zinc ion binding				0	all_neural(191;0.0982)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.82e-07)|Epithelial(86;1.51e-06)|all cancers(50;2.35e-05)		CCTCTCCCCCGGGGGCCCCAG	0.706			NA											2	4	---	---	---	---	NA	NA	NA	NA	NA
FLT1	2321	broad.mit.edu	37	13	28908231	28908231	+	Frame_Shift_Del	DEL	C	C	-	rs66533628		TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr13:28908231delC	uc001usb.3	-	18	2809	c.2524delG	c.(2524-2526)GTTfs	p.V842fs	FLT1_uc001usa.3_Frame_Shift_Del_p.V60fs	NM_002019	NP_002010	P17948	VGFR1_HUMAN	fms-related tyrosine kinase 1 isoform 1	842	Cytoplasmic (Potential).|Protein kinase.				cell differentiation|female pregnancy|positive regulation of vascular endothelial growth factor receptor signaling pathway	extracellular space|Golgi apparatus|integral to plasma membrane|nucleus	ATP binding|growth factor binding|vascular endothelial growth factor receptor activity			lung(10)|central_nervous_system(5)|ovary(3)|stomach(2)|skin(2)|urinary_tract(1)|breast(1)	24	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0262)|Breast(139;0.188)	Colorectal(13;0.000674)	all cancers(112;0.0301)|Epithelial(112;0.155)|GBM - Glioblastoma multiforme(144;0.184)|OV - Ovarian serous cystadenocarcinoma(117;0.205)|Lung(94;0.207)	Sunitinib(DB01268)	GATGCTTGAACCACTTTTCCA	0.433			NA											71	236	---	---	---	---	NA	NA	NA	NA	NA
SLITRK1	114798	broad.mit.edu	37	13	84455198	84455198	+	Frame_Shift_Del	DEL	C	C	-			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr13:84455198delC	uc001vlk.2	-	1	1331	c.445delG	c.(445-447)GCCfs	p.A149fs		NM_052910	NP_443142	Q96PX8	SLIK1_HUMAN	slit and trk like 1 protein precursor	149	LRR 4.|Extracellular (Potential).					integral to membrane				ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	5	Medulloblastoma(90;0.18)	Breast(118;0.212)		GBM - Glioblastoma multiforme(99;0.07)		TCCTGGAAGGCCCCCGGGTCT	0.468			NA											21	62	---	---	---	---	NA	NA	NA	NA	NA
ADAM21	8747	broad.mit.edu	37	14	70925698	70925698	+	Frame_Shift_Del	DEL	C	C	-			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr14:70925698delC	uc001xmd.2	+	1	1482	c.1482delC	c.(1480-1482)ATCfs	p.I494fs		NM_003813	NP_003804	Q9UKJ8	ADA21_HUMAN	ADAM metallopeptidase domain 21 preproprotein	494	Cys-rich.|Extracellular (Potential).				proteolysis|single fertilization	integral to membrane	metalloendopeptidase activity|zinc ion binding			pancreas(1)|skin(1)	2				all cancers(60;0.00326)|BRCA - Breast invasive adenocarcinoma(234;0.00646)|OV - Ovarian serous cystadenocarcinoma(108;0.0401)		AGGACGGGATCCCCTGTAGTG	0.448			NA											25	85	---	---	---	---	NA	NA	NA	NA	NA
PELP1	27043	broad.mit.edu	37	17	4575456	4575456	+	Frame_Shift_Del	DEL	C	C	-			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr17:4575456delC	uc002fyi.3	-	16	3056	c.2830delG	c.(2830-2832)GAAfs	p.E944fs	PELP1_uc010vsf.1_Frame_Shift_Del_p.E797fs	NM_014389	NP_055204	Q8IZL8	PELP1_HUMAN	proline, glutamic acid and leucine rich protein	944	Glu-rich.				transcription, DNA-dependent	cytoplasm|MLL1 complex	protein binding			ovary(1)|central_nervous_system(1)	2						tcttcttcttcctctaactca	0.179			NA											2	4	---	---	---	---	NA	NA	NA	NA	NA
GAS2L2	246176	broad.mit.edu	37	17	34072570	34072570	+	Frame_Shift_Del	DEL	C	C	-	rs112674267	byFrequency	TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr17:34072570delC	uc002hjv.1	-	6	1974	c.1946delG	c.(1945-1947)GGTfs	p.G649fs		NM_139285	NP_644814	Q8NHY3	GA2L2_HUMAN	growth arrest-specific 2 like 2	649					cell cycle arrest	cytoplasm|cytoskeleton				ovary(1)|skin(1)	2		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		GTCATAAGGACCCCCAGGCTC	0.627			NA											39	83	---	---	---	---	NA	NA	NA	NA	NA
KCNJ2	3759	broad.mit.edu	37	17	68171721	68171734	+	Frame_Shift_Del	DEL	GCCAAGATGGCAAA	GCCAAGATGGCAAA	-			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	GCCAAGATGGCAAA	GCCAAGATGGCAAA	-	-	GCCAAGATGGCAAA	GCCAAGATGGCAAA	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr17:68171721_68171734delGCCAAGATGGCAAA	uc010dfg.2	+	2	942_955	c.541_554delGCCAAGATGGCAAA	c.(541-555)GCCAAGATGGCAAAGfs	p.A181fs	KCNJ2_uc002jir.2_Frame_Shift_Del_p.A181fs	NM_000891	NP_000882	P63252	IRK2_HUMAN	potassium inwardly-rectifying channel J2	181_185	Cytoplasmic (By similarity).				synaptic transmission	integral to plasma membrane	inward rectifier potassium channel activity|protein binding				0	Breast(10;1.64e-08)					CGCAGTCATGGCCAAGATGGCAAAGCCAAAGAAG	0.5			NA											9	82	---	---	---	---	NA	NA	NA	NA	NA
CA11	770	broad.mit.edu	37	19	49147712	49147712	+	Frame_Shift_Del	DEL	G	G	-			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr19:49147712delG	uc002pjz.1	-	3	819	c.257delC	c.(256-258)CCAfs	p.P86fs	SEC1_uc010xzv.1_Intron|SEC1_uc002pka.2_Intron|SEC1_uc010xzw.1_Intron|SEC1_uc010ema.2_Intron	NM_001217	NP_001208	O75493	CAH11_HUMAN	carbonic anhydrase XI precursor	86						extracellular region					0		all_epithelial(76;2.38e-06)|all_lung(116;4.89e-06)|Lung NSC(112;9.34e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.000103)|all cancers(93;0.000119)|GBM - Glioblastoma multiforme(486;0.00634)|Epithelial(262;0.016)		GAGCCTTAATGGGGGCAGAAA	0.587			NA											24	32	---	---	---	---	NA	NA	NA	NA	NA
KLK6	5653	broad.mit.edu	37	19	51465069	51465069	+	Frame_Shift_Del	DEL	G	G	-			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr19:51465069delG	uc002pui.2	-	6	773	c.513delC	c.(511-513)GCCfs	p.A171fs	KLK6_uc010eoj.2_Intron|KLK6_uc002puh.2_Frame_Shift_Del_p.A180fs|KLK6_uc002puj.2_Frame_Shift_Del_p.A64fs|KLK6_uc010ycn.1_Frame_Shift_Del_p.A64fs|KLK6_uc002pul.2_Frame_Shift_Del_p.A171fs|KLK6_uc002pum.2_Frame_Shift_Del_p.A64fs	NM_001012964	NP_001012982	Q92876	KLK6_HUMAN	kallikrein-related peptidase 6 isoform A	171	Peptidase S1.				amyloid precursor protein metabolic process|central nervous system development|collagen catabolic process|hormone metabolic process|myelination|positive regulation of G-protein coupled receptor protein signaling pathway|protein autoprocessing|proteolysis|regulation of cell differentiation|tissue regeneration	endoplasmic reticulum|extracellular region|microsome|mitochondrion|nucleolus	protein binding|serine-type endopeptidase activity				0		all_neural(266;0.026)		OV - Ovarian serous cystadenocarcinoma(262;0.00372)|GBM - Glioblastoma multiforme(134;0.00871)		GGCCAGGGTAGGCATGCTCAC	0.552			NA											109	79	---	---	---	---	NA	NA	NA	NA	NA
NT5C1B	93034	broad.mit.edu	37	2	18768815	18768816	+	Frame_Shift_Ins	INS	-	-	G			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr2:18768815_18768816insG	uc002rcz.2	-	2	177_178	c.73_74insC	c.(73-75)GAAfs	p.E25fs	NT5C1B_uc002rcy.2_Frame_Shift_Ins_p.E25fs|NT5C1B_uc010exr.2_Frame_Shift_Ins_p.E25fs|NT5C1B_uc010yju.1_Frame_Shift_Ins_p.E25fs|NT5C1B_uc002rda.2_Frame_Shift_Ins_p.E25fs|NT5C1B_uc010yjv.1_Frame_Shift_Ins_p.E25fs|NT5C1B_uc010yjw.1_Frame_Shift_Ins_p.E25fs|NT5C1B_uc010exs.2_Frame_Shift_Ins_p.E25fs|NT5C1B_uc002rdb.1_5'Flank	NM_001002006	NP_001002006	Q96P26	5NT1B_HUMAN	5' nucleotidase, cytosolic IB isoform 1	25					purine base metabolic process|purine nucleotide catabolic process	cytosol	5'-nucleotidase activity|magnesium ion binding|nucleotide binding			skin(2)|ovary(1)	3	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.177)	Ovarian(717;0.208)				CTTTCTTTTTTCTGCTTCTAGA	0.391			NA											40	105	---	---	---	---	NA	NA	NA	NA	NA
PTPRN	5798	broad.mit.edu	37	2	220167204	220167204	+	Frame_Shift_Del	DEL	G	G	-			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr2:220167204delG	uc002vkz.2	-	6	738	c.649delC	c.(649-651)CGTfs	p.R217fs	PTPRN_uc010zlc.1_Frame_Shift_Del_p.R127fs|PTPRN_uc002vla.2_Frame_Shift_Del_p.R217fs	NM_002846	NP_002837	Q16849	PTPRN_HUMAN	protein tyrosine phosphatase, receptor type, N	217	Extracellular (Potential).				response to reactive oxygen species	integral to plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			ovary(2)|lung(1)|skin(1)	4		Renal(207;0.0474)		Epithelial(149;4.22e-07)|all cancers(144;8.82e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)|STAD - Stomach adenocarcinoma(1183;0.0875)		GAGCCATCACGGGAGCCAAAC	0.617			NA											30	32	---	---	---	---	NA	NA	NA	NA	NA
ANKRD5	63926	broad.mit.edu	37	20	10030742	10030742	+	Frame_Shift_Del	DEL	A	A	-			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr20:10030742delA	uc002wno.2	+	7	1918	c.1525delA	c.(1525-1527)AAAfs	p.K509fs	uc002wnn.1_Intron|ANKRD5_uc002wnp.2_Frame_Shift_Del_p.K509fs|ANKRD5_uc010gbz.2_Frame_Shift_Del_p.K320fs	NM_022096	NP_071379	Q9NU02	ANKR5_HUMAN	ankyrin repeat domain protein 5	509							calcium ion binding			ovary(1)|breast(1)	2						GGCTTCTCTGAAAAAGGCCTT	0.393			NA											13	27	---	---	---	---	NA	NA	NA	NA	NA
MPPED1	758	broad.mit.edu	37	22	43831041	43831042	+	Frame_Shift_Ins	INS	-	-	A			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr22:43831041_43831042insA	uc011apv.1	+	3	535_536	c.312_313insA	c.(310-315)CCCATCfs	p.P104fs	MPPED1_uc011apw.1_5'UTR|MPPED1_uc011apx.1_Intron|MPPED1_uc011apy.1_Frame_Shift_Ins_p.P104fs|MPPED1_uc011apz.1_Frame_Shift_Ins_p.P137fs	NM_001044370	NP_001037835	O15442	MPPD1_HUMAN	metallophosphoesterase domain containing 1	104_105							hydrolase activity				0		all_neural(38;0.0244)|Ovarian(80;0.0694)				GGACGGACCCCATCCAGATGCC	0.634			NA											34	134	---	---	---	---	NA	NA	NA	NA	NA
SLC7A14	57709	broad.mit.edu	37	3	170198544	170198544	+	Frame_Shift_Del	DEL	G	G	-			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr3:170198544delG	uc003fgz.2	-	7	1843	c.1527delC	c.(1525-1527)CCCfs	p.P509fs	CLDN11_uc011bpt.1_Intron|uc003fha.1_Intron	NM_020949	NP_066000	Q8TBB6	S7A14_HUMAN	solute carrier family 7 (cationic amino acid	509						integral to membrane	amino acid transmembrane transporter activity			ovary(2)|upper_aerodigestive_tract(1)|liver(1)|central_nervous_system(1)	5	all_cancers(22;2.41e-22)|all_epithelial(15;4.2e-27)|all_lung(20;1.17e-16)|Lung NSC(18;4.91e-16)|Ovarian(172;0.000902)|Breast(254;0.137)		Lung(28;6.23e-13)|LUSC - Lung squamous cell carcinoma(14;1.48e-12)			TGCCGTAATTGGGGTGGTTGA	0.453			NA											48	176	---	---	---	---	NA	NA	NA	NA	NA
KCTD8	386617	broad.mit.edu	37	4	44176951	44176951	+	Frame_Shift_Del	DEL	G	G	-			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr4:44176951delG	uc003gwu.2	-	2	1562	c.1278delC	c.(1276-1278)TCCfs	p.S426fs		NM_198353	NP_938167	Q6ZWB6	KCTD8_HUMAN	potassium channel tetramerisation domain	426						cell junction|postsynaptic membrane|presynaptic membrane|voltage-gated potassium channel complex	voltage-gated potassium channel activity			central_nervous_system(2)|ovary(1)	3						CTTTCTTTTTGGACAGATTTG	0.403			NA								HNSCC(17;0.042)			36	151	---	---	---	---	NA	NA	NA	NA	NA
FBXW7	55294	broad.mit.edu	37	4	153259062	153259062	+	Frame_Shift_Del	DEL	A	A	-			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr4:153259062delA	uc003ims.2	-	5	902	c.753delT	c.(751-753)CTTfs	p.L251fs	FBXW7_uc011cii.1_Frame_Shift_Del_p.L251fs|FBXW7_uc003imt.2_Frame_Shift_Del_p.L251fs|FBXW7_uc011cih.1_Frame_Shift_Del_p.L75fs|FBXW7_uc003imq.2_Frame_Shift_Del_p.L171fs|FBXW7_uc003imr.2_Frame_Shift_Del_p.L133fs	NM_033632	NP_361014	Q969H0	FBXW7_HUMAN	F-box and WD repeat domain containing 7 isoform	251					interspecies interaction between organisms|lipid homeostasis|negative regulation of DNA endoreduplication|negative regulation of hepatocyte proliferation|negative regulation of Notch signaling pathway|negative regulation of triglyceride biosynthetic process|positive regulation of epidermal growth factor receptor activity|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein stabilization|protein ubiquitination|regulation of lipid storage|regulation of protein localization|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|sister chromatid cohesion|vasculature development	nucleolus|nucleolus|nucleoplasm|nucleoplasm|SCF ubiquitin ligase complex	protein binding|protein binding			haematopoietic_and_lymphoid_tissue(125)|large_intestine(99)|stomach(16)|lung(14)|endometrium(13)|ovary(9)|biliary_tract(8)|upper_aerodigestive_tract(5)|central_nervous_system(3)|kidney(3)|skin(3)|pancreas(3)|breast(2)|prostate(2)|cervix(1)|NS(1)|bone(1)	308	all_hematologic(180;0.093)	Acute lymphoblastic leukemia(8;0.000629)|all_hematologic(8;0.067)				CATCTAAAGCAAGCAATTTCT	0.358			NA	Mis|N|D|F		colorectal|endometrial|T-ALL								11	44	---	---	---	---	NA	NA	NA	NA	NA
ZFP57	346171	broad.mit.edu	37	6	29640370	29640370	+	Frame_Shift_Del	DEL	G	G	-			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr6:29640370delG	uc011dlw.1	-	4	1669	c.1518delC	c.(1516-1518)CCCfs	p.P506fs	ZFP57_uc003nnl.3_Frame_Shift_Del_p.P486fs	NM_001109809	NP_001103279	Q9NU63	ZFP57_HUMAN	zinc finger protein 57 homolog	422					DNA methylation involved in embryo development|regulation of gene expression by genetic imprinting|transcription, DNA-dependent		DNA binding|zinc ion binding			ovary(3)|skin(2)	5						TATGGATCCTGGGGGGAGATT	0.517			NA											10	38	---	---	---	---	NA	NA	NA	NA	NA
DNAH8	1769	broad.mit.edu	37	6	38771088	38771089	+	Splice_Site	INS	-	-	T			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr6:38771088_38771089insT	uc003ooe.1	+	20	2983	c.2383_splice	c.e20+1	p.E795_splice		NM_001371	NP_001362			dynein, axonemal, heavy polypeptide 8											skin(8)|ovary(7)|lung(2)|large_intestine(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	21						AAACAGTCAGGTAACTTTTCTC	0.262			NA											15	59	---	---	---	---	NA	NA	NA	NA	NA
LPA	4018	broad.mit.edu	37	6	161020604	161020604	+	Frame_Shift_Del	DEL	C	C	-			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr6:161020604delC	uc003qtl.2	-	21	3335	c.3215delG	c.(3214-3216)GGAfs	p.G1072fs		NM_005577	NP_005568	P08519	APOA_HUMAN	lipoprotein Lp(a) precursor	3580	Kringle 32.				blood circulation|lipid metabolic process|lipid transport|lipoprotein metabolic process|proteolysis|receptor-mediated endocytosis	plasma lipoprotein particle	apolipoprotein binding|endopeptidase inhibitor activity|fibronectin binding|heparin binding|serine-type endopeptidase activity			ovary(3)|skin(2)|pancreas(1)	6		Breast(66;0.000496)|Ovarian(120;0.0303)|Prostate(117;0.0965)		OV - Ovarian serous cystadenocarcinoma(65;2.5e-17)|BRCA - Breast invasive adenocarcinoma(81;6.48e-06)	Aminocaproic Acid(DB00513)	GCAAGTTCTTCCTGTGACAGT	0.483			NA											82	329	---	---	---	---	NA	NA	NA	NA	NA
CROT	54677	broad.mit.edu	37	7	87022321	87022321	+	Frame_Shift_Del	DEL	G	G	-			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr7:87022321delG	uc003uit.2	+	17	1901	c.1656delG	c.(1654-1656)CAGfs	p.Q552fs	CROT_uc003uiu.2_Frame_Shift_Del_p.Q580fs	NM_021151	NP_066974	Q9UKG9	OCTC_HUMAN	peroxisomal carnitine O-octanoyltransferase	552					fatty acid beta-oxidation using acyl-CoA oxidase|generation of precursor metabolites and energy|transport	peroxisomal matrix	carnitine O-octanoyltransferase activity			ovary(2)|lung(1)	3	Esophageal squamous(14;0.0058)|all_lung(186;0.201)|Lung NSC(181;0.203)				L-Carnitine(DB00583)	TACGAGTCCAGGGAGTGGTAG	0.418			NA											45	121	---	---	---	---	NA	NA	NA	NA	NA
CSMD3	114788	broad.mit.edu	37	8	113697737	113697737	+	Frame_Shift_Del	DEL	C	C	-			TCGA-55-7907-01A-11D-2167-08	TCGA-55-7907-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dbafe19-dd11-4a91-b946-ebd346121b64	643450d7-0116-4289-a05d-ab41e2d3f5fb	g.chr8:113697737delC	uc003ynu.2	-	15	2539	c.2380delG	c.(2380-2382)GCTfs	p.A794fs	CSMD3_uc003yns.2_Frame_Shift_Del_p.A66fs|CSMD3_uc003ynt.2_Frame_Shift_Del_p.A754fs|CSMD3_uc011lhx.1_Frame_Shift_Del_p.A690fs	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	794	Extracellular (Potential).|CUB 4.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						GGCACCTCAGCCCCAGTAAAG	0.433			NA								HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			22	91	---	---	---	---	NA	NA	NA	NA	NA