Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	ACHILLES_Top_Genes	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
STX12	23673	broad.mit.edu	37	1	28148801	28148801	+	Missense_Mutation	SNP	C	C	G			TCGA-55-6986-01A-11D-1945-08	TCGA-55-6986-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5a7f3c88-ef02-4e97-8009-5622245b6a09	2d60408f-5a74-4cd1-a27e-168d1d3379e6	g.chr1:28148801C>G	uc001bou.3	+	9	917	c.792C>G	c.(790-792)ATC>ATG	p.I264M		NM_177424	NP_803173	Q86Y82	STX12_HUMAN	syntaxin 12	264	Helical; Anchor for type IV membrane protein; (Potential).				cholesterol efflux|intracellular protein transport|protein stabilization|vesicle-mediated transport	Golgi apparatus|integral to membrane|membrane raft|phagocytic vesicle	SNAP receptor activity			breast(1)|central_nervous_system(1)	2		Colorectal(325;3.46e-05)|all_lung(284;9.43e-05)|Lung NSC(340;0.000185)|Renal(390;0.00121)|Breast(348;0.0021)|Ovarian(437;0.00503)|all_neural(195;0.0208)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0434)|OV - Ovarian serous cystadenocarcinoma(117;3.96e-24)|Colorectal(126;3.46e-08)|COAD - Colon adenocarcinoma(152;1.83e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00258)|KIRC - Kidney renal clear cell carcinoma(1967;0.00302)|STAD - Stomach adenocarcinoma(196;0.00311)|READ - Rectum adenocarcinoma(331;0.0649)		TTATTCTAATCTTGGGACTTA	0.403	Ovarian(5;5 342 2097 9488 34083)		NA											13	45					0	0	0.013537	0	0
PGM1	5236	broad.mit.edu	37	1	64097453	64097453	+	Missense_Mutation	SNP	G	G	A			TCGA-55-6986-01A-11D-1945-08	TCGA-55-6986-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5a7f3c88-ef02-4e97-8009-5622245b6a09	2d60408f-5a74-4cd1-a27e-168d1d3379e6	g.chr1:64097453G>A	uc001dbh.2	+	4	895	c.682G>A	c.(682-684)GTT>ATT	p.V228I	PGM1_uc010ooy.1_Missense_Mutation_p.V31I|PGM1_uc010ooz.1_Missense_Mutation_p.V246I	NM_002633	NP_002624	P36871	PGM1_HUMAN	phosphoglucomutase 1	228					cellular calcium ion homeostasis|galactose catabolic process|glucose 1-phosphate metabolic process|glycogen biosynthetic process|glycogen catabolic process	cytosol	magnesium ion binding|phosphoglucomutase activity			ovary(2)|kidney(1)	3						TATGCATGGAGGTATACAATC	0.408			NA											3	51					0	0	0.004672	0	0
NBPF10	100132406	broad.mit.edu	37	1	145359169	145359169	+	Missense_Mutation	SNP	T	T	A			TCGA-55-6986-01A-11D-1945-08	TCGA-55-6986-11A-01D-1945-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5a7f3c88-ef02-4e97-8009-5622245b6a09	2d60408f-5a74-4cd1-a27e-168d1d3379e6	g.chr1:145359169T>A	uc001end.3	+	74	9369	c.9334T>A	c.(9334-9336)TTG>ATG	p.L3112M	NBPF9_uc010oye.1_Intron|NBPF10_uc001emp.3_Intron|NBPF10_uc010oyi.1_Intron|NBPF10_uc010oyk.1_Intron|NBPF10_uc010oyl.1_Intron|NBPF10_uc001enc.2_Intron|NBPF10_uc010oyq.1_Intron|NBPF10_uc010oyr.1_Intron	NM_001039703	NP_001034792	A6NDV3	A6NDV3_HUMAN	hypothetical protein LOC100132406	3037											0	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		GCGTGTTGGCTTGGCTGTTGA	0.458			NA											6	279					0	0	0.001168	0	0
KIF11	3832	broad.mit.edu	37	10	94368781	94368781	+	Missense_Mutation	SNP	C	C	T			TCGA-55-6986-01A-11D-1945-08	TCGA-55-6986-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5a7f3c88-ef02-4e97-8009-5622245b6a09	2d60408f-5a74-4cd1-a27e-168d1d3379e6	g.chr10:94368781C>T	uc001kic.2	+	5	700	c.392C>T	c.(391-393)CCC>CTC	p.P131L	KIF11_uc010qnq.1_Intron	NM_004523	NP_004514	P52732	KIF11_HUMAN	kinesin family member 11	131	Kinesin-motor.				blood coagulation|cell division|microtubule-based movement|spindle assembly involved in mitosis	chromatin remodeling complex|cytosol|kinesin complex|microtubule|spindle pole	ATP binding|microtubule motor activity|protein kinase binding			skin(1)	1						TTTCAGGATCCCTTGGCTGGT	0.328	Colon(47;212 1003 2764 4062 8431)		NA											8	12					0	0	0.00308	0	0
PNLIPRP1	5407	broad.mit.edu	37	10	118360598	118360598	+	Silent	SNP	G	G	A			TCGA-55-6986-01A-11D-1945-08	TCGA-55-6986-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5a7f3c88-ef02-4e97-8009-5622245b6a09	2d60408f-5a74-4cd1-a27e-168d1d3379e6	g.chr10:118360598G>A	uc001lco.1	+	10	966	c.948G>A	c.(946-948)CCG>CCA	p.P316P	PNLIPRP1_uc001lcp.2_Silent_p.P316P	NM_006229	NP_006220	P54315	LIPR1_HUMAN	pancreatic lipase-related protein 1 precursor	316					lipid metabolic process		calcium ion binding|triglyceride lipase activity			ovary(1)|breast(1)	2				all cancers(201;0.0161)		AGTGCTTCCCGTGTCCAGATC	0.398			NA											16	40					0	0	0.007413	0	0
DPF2	5977	broad.mit.edu	37	11	65116348	65116348	+	Missense_Mutation	SNP	G	G	A			TCGA-55-6986-01A-11D-1945-08	TCGA-55-6986-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5a7f3c88-ef02-4e97-8009-5622245b6a09	2d60408f-5a74-4cd1-a27e-168d1d3379e6	g.chr11:65116348G>A	uc001odm.2	+	10	1057	c.1045G>A	c.(1045-1047)GAT>AAT	p.D349N	DPF2_uc001odn.2_Missense_Mutation_p.D363N|DPF2_uc010roe.1_Missense_Mutation_p.D165N	NM_006268	NP_006259	Q92785	REQU_HUMAN	D4, zinc and double PHD fingers family 2	349	PHD-type 2.				apoptosis|induction of apoptosis by extracellular signals|regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|nucleus	nucleic acid binding|zinc ion binding			ovary(1)	1						TGATGACTGCGATCGTGGCTA	0.488			NA											10	42					0	0	0.006214	0	0
EFEMP2	30008	broad.mit.edu	37	11	65636001	65636001	+	Missense_Mutation	SNP	A	A	G			TCGA-55-6986-01A-11D-1945-08	TCGA-55-6986-11A-01D-1945-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5a7f3c88-ef02-4e97-8009-5622245b6a09	2d60408f-5a74-4cd1-a27e-168d1d3379e6	g.chr11:65636001A>G	uc001ofy.3	-	8	1021	c.827T>C	c.(826-828)CTG>CCG	p.L276P	EFEMP2_uc001ofz.2_RNA|EFEMP2_uc001oga.2_Missense_Mutation_p.L276P	NM_016938	NP_058634	O95967	FBLN4_HUMAN	EGF-containing fibulin-like extracellular matrix	276	EGF-like 5; calcium-binding (Potential).				blood coagulation	basement membrane|membrane	calcium ion binding|extracellular matrix structural constituent|protein binding|transmembrane receptor activity			ovary(1)	1				READ - Rectum adenocarcinoma(159;0.169)		GCGTGTGGCCAGCAGCTGGTA	0.627			NA											5	33					0	0	0.004482	0	0
PRB1	5542	broad.mit.edu	37	12	11506399	11506399	+	Missense_Mutation	SNP	T	T	C	rs111543911		TCGA-55-6986-01A-11D-1945-08	TCGA-55-6986-11A-01D-1945-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5a7f3c88-ef02-4e97-8009-5622245b6a09	2d60408f-5a74-4cd1-a27e-168d1d3379e6	g.chr12:11506399T>C	uc001qzw.1	-	4	675	c.638A>G	c.(637-639)CAA>CGA	p.Q213R	PRB1_uc001qzu.1_Intron|PRB1_uc001qzv.1_Intron	NM_005039	NP_005030	P04280	PRP1_HUMAN	proline-rich protein BstNI subfamily 1 isoform 1	274	11.|15 X 20 AA approximate tandem repeats of P-P-G-K-P-Q-G-P-P-[PAQ]-Q-[GE]-[GD]- [NKS]-[KSQRN]-[PRQS]-[QS] [GPS]-[PQAR]- [PSR].		Missing (in clone CP-4).|Missing (in clone CP-5).	Q -> R (in Ref. 5; CAA30395).		extracellular region					0			OV - Ovarian serous cystadenocarcinoma(49;0.185)			TGGAGGAGATTGGGAACTTCG	0.612			NA											5	38					0	0	0.006214	0	0
C14orf43	91748	broad.mit.edu	37	14	74203721	74203721	+	Missense_Mutation	SNP	C	C	T	rs150626971		TCGA-55-6986-01A-11D-1945-08	TCGA-55-6986-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5a7f3c88-ef02-4e97-8009-5622245b6a09	2d60408f-5a74-4cd1-a27e-168d1d3379e6	g.chr14:74203721C>T	uc001xot.2	-	3	2512	c.1729G>A	c.(1729-1731)GGG>AGG	p.G577R	C14orf43_uc001xou.2_Missense_Mutation_p.G577R|C14orf43_uc010tud.1_Missense_Mutation_p.G577R|C14orf43_uc010arw.2_RNA	NM_194278	NP_919254	Q6PJG2	CN043_HUMAN	hypothetical protein LOC91748	577					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(4)|central_nervous_system(1)	5				BRCA - Breast invasive adenocarcinoma(234;0.00358)|KIRC - Kidney renal clear cell carcinoma(182;0.0878)|OV - Ovarian serous cystadenocarcinoma(108;0.115)		GCATCTGTCCCGGGGATTCGG	0.607			NA											4	41					0	0	0.014758	0	0
ALDH6A1	4329	broad.mit.edu	37	14	74551056	74551056	+	Silent	SNP	G	G	A			TCGA-55-6986-01A-11D-1945-08	TCGA-55-6986-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5a7f3c88-ef02-4e97-8009-5622245b6a09	2d60408f-5a74-4cd1-a27e-168d1d3379e6	g.chr14:74551056G>A	uc001xpo.2	-	1	141	c.42C>T	c.(40-42)ATC>ATT	p.I14I	LIN52_uc001xpp.2_5'Flank|LIN52_uc010asb.2_5'Flank|ALDH6A1_uc010asa.2_5'UTR|ALDH6A1_uc010tuq.1_Silent_p.I14I	NM_005589	NP_005580	Q02252	MMSA_HUMAN	aldehyde dehydrogenase 6A1 precursor	14						mitochondrial matrix|nucleus	fatty-acyl-CoA binding|malonate-semialdehyde dehydrogenase (acetylating) activity|methylmalonate-semialdehyde dehydrogenase (acylating) activity				0				BRCA - Breast invasive adenocarcinoma(234;0.00354)	NADH(DB00157)	TCGCCTGCAGGATCCGGGCTC	0.667			NA											4	36					0	0	0.009096	0	0
C15orf52	388115	broad.mit.edu	37	15	40628778	40628778	+	Missense_Mutation	SNP	C	C	T			TCGA-55-6986-01A-11D-1945-08	TCGA-55-6986-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5a7f3c88-ef02-4e97-8009-5622245b6a09	2d60408f-5a74-4cd1-a27e-168d1d3379e6	g.chr15:40628778C>T	uc001zlh.3	-	9	1032	c.1016G>A	c.(1015-1017)CGA>CAA	p.R339Q	C15orf52_uc001zli.1_3'UTR|C15orf52_uc010ucn.1_Missense_Mutation_p.R129Q	NM_207380	NP_997263	Q6ZUT6	CO052_HUMAN	hypothetical protein LOC388115	339										large_intestine(1)	1		all_cancers(109;9.35e-19)|all_epithelial(112;1.18e-15)|Lung NSC(122;2.45e-11)|all_lung(180;6.47e-10)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;9.06e-06)|Colorectal(105;0.0107)|BRCA - Breast invasive adenocarcinoma(123;0.0505)|READ - Rectum adenocarcinoma(2;0.0649)|Lung(196;0.0781)|LUAD - Lung adenocarcinoma(183;0.0841)		CTGTTACCTTCGGGCCCTGCC	0.652			NA											7	53					0	0	0.00308	0	0
TEKT3	64518	broad.mit.edu	37	17	15234676	15234676	+	Missense_Mutation	SNP	G	G	A			TCGA-55-6986-01A-11D-1945-08	TCGA-55-6986-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5a7f3c88-ef02-4e97-8009-5622245b6a09	2d60408f-5a74-4cd1-a27e-168d1d3379e6	g.chr17:15234676G>A	uc002gon.2	-	3	414	c.227C>T	c.(226-228)TCC>TTC	p.S76F		NM_031898	NP_114104	Q9BXF9	TEKT3_HUMAN	tektin 3	76					microtubule cytoskeleton organization	cilium axoneme|flagellar axoneme|microtubule				ovary(2)	2				UCEC - Uterine corpus endometrioid carcinoma (92;0.0877)		GGTATTCTCGGACACCCTCTG	0.502			NA											5	72					0	0	0.014758	0	0
SSTR2	6752	broad.mit.edu	37	17	71165803	71165803	+	Silent	SNP	C	C	T			TCGA-55-6986-01A-11D-1945-08	TCGA-55-6986-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5a7f3c88-ef02-4e97-8009-5622245b6a09	2d60408f-5a74-4cd1-a27e-168d1d3379e6	g.chr17:71165803C>T	uc002jje.2	+	2	705	c.345C>T	c.(343-345)TGC>TGT	p.C115C		NM_001050	NP_001041	P30874	SSR2_HUMAN	somatostatin receptor 2	115	Extracellular (Potential).				digestion|negative regulation of cell proliferation|response to nutrient	integral to plasma membrane	PDZ domain binding|somatostatin receptor activity				0			LUSC - Lung squamous cell carcinoma(166;0.197)			AGGCCATTTGCCGGGTGGTCA	0.562			NA											9	39					0	0	0.004482	0	0
EMILIN2	84034	broad.mit.edu	37	18	2891825	2891825	+	Missense_Mutation	SNP	C	C	T			TCGA-55-6986-01A-11D-1945-08	TCGA-55-6986-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5a7f3c88-ef02-4e97-8009-5622245b6a09	2d60408f-5a74-4cd1-a27e-168d1d3379e6	g.chr18:2891825C>T	uc002kln.2	+	4	1859	c.1700C>T	c.(1699-1701)GCC>GTC	p.A567V		NM_032048	NP_114437	Q9BXX0	EMIL2_HUMAN	elastin microfibril interfacer 2 precursor	567					cell adhesion	collagen	extracellular matrix constituent conferring elasticity|protein binding			skin(2)|ovary(1)	3				READ - Rectum adenocarcinoma(2;0.1)		ATGGAAGGTGCCTTGCCAAAC	0.493			NA											5	45					0	0	0.014758	0	0
PSG8	440533	broad.mit.edu	37	19	43268115	43268115	+	Missense_Mutation	SNP	C	C	T			TCGA-55-6986-01A-11D-1945-08	TCGA-55-6986-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5a7f3c88-ef02-4e97-8009-5622245b6a09	2d60408f-5a74-4cd1-a27e-168d1d3379e6	g.chr19:43268115C>T	uc002ouo.2	-	2	481	c.383G>A	c.(382-384)GGT>GAT	p.G128D	PSG3_uc002ouf.2_Intron|PSG1_uc002oug.1_Intron|PSG8_uc002oui.2_Intron|PSG8_uc002ouh.2_Missense_Mutation_p.G128D|PSG8_uc010ein.2_Intron|PSG8_uc002ouj.3_Missense_Mutation_p.G3D|PSG8_uc002ouk.3_Intron|PSG8_uc002oul.3_Missense_Mutation_p.G128D|PSG8_uc002oum.3_Missense_Mutation_p.G128D|PSG1_uc002oun.2_Intron|PSG8_uc002oup.3_Missense_Mutation_p.G128D	NM_182707	NP_874366	Q9UQ74	PSG8_HUMAN	pregnancy specific beta-1-glycoprotein 8 isoform	128	Ig-like V-type.					extracellular region					0		Prostate(69;0.00899)				ATTCTCATCACCTCCCATTAT	0.468			NA											22	224					0	0	0.014323	0	0
PSG4	5672	broad.mit.edu	37	19	43699308	43699308	+	Missense_Mutation	SNP	T	T	C			TCGA-55-6986-01A-11D-1945-08	TCGA-55-6986-11A-01D-1945-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5a7f3c88-ef02-4e97-8009-5622245b6a09	2d60408f-5a74-4cd1-a27e-168d1d3379e6	g.chr19:43699308T>C	uc002ovy.2	-	4	929	c.827A>G	c.(826-828)AAT>AGT	p.N276S	PSG6_uc010xwk.1_Intron|PSG4_uc002owa.2_RNA|PSG4_uc002owb.2_Missense_Mutation_p.N183S|PSG4_uc002ovz.2_Intron	NM_002780	NP_002771	Q00888	PSG4_HUMAN	pregnancy specific beta-1-glycoprotein 4 isoform	276	Ig-like C2-type 2.				defense response|female pregnancy	extracellular region				ovary(1)	1		Prostate(69;0.00682)				GCTCTGACCATTTAGCCACCA	0.433			NA											10	165					0	0	0.01892	0	0
WDR69	164781	broad.mit.edu	37	2	228762934	228762934	+	Silent	SNP	T	T	C			TCGA-55-6986-01A-11D-1945-08	TCGA-55-6986-11A-01D-1945-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5a7f3c88-ef02-4e97-8009-5622245b6a09	2d60408f-5a74-4cd1-a27e-168d1d3379e6	g.chr2:228762934T>C	uc002vpn.1	+	6	556	c.477T>C	c.(475-477)TGT>TGC	p.C159C	WDR69_uc010zlw.1_Silent_p.C144C|WDR69_uc002vpo.1_RNA	NM_178821	NP_849143	Q8N136	WDR69_HUMAN	WD repeat domain 69	159	WD 2.									breast(1)	1		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;1.22e-10)|all cancers(144;8.11e-08)|Lung(261;0.011)|LUSC - Lung squamous cell carcinoma(224;0.0148)		ATAAAACTTGTAAACTCTGGA	0.279			NA											5	25					0	0	0.001168	0	0
FAM83C	128876	broad.mit.edu	37	20	33874757	33874757	+	Missense_Mutation	SNP	G	G	T			TCGA-55-6986-01A-11D-1945-08	TCGA-55-6986-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5a7f3c88-ef02-4e97-8009-5622245b6a09	2d60408f-5a74-4cd1-a27e-168d1d3379e6	g.chr20:33874757G>T	uc010zux.1	-	4	1943	c.1825C>A	c.(1825-1827)CCC>ACC	p.P609T	EIF6_uc002xbv.1_5'Flank|EIF6_uc002xbx.1_5'Flank|EIF6_uc002xbz.1_5'Flank|EIF6_uc002xby.1_5'Flank|FAM83C_uc002xcb.1_Missense_Mutation_p.P264T	NM_178468	NP_848563	Q9BQN1	FA83C_HUMAN	hypothetical protein LOC128876	609										ovary(2)	2			BRCA - Breast invasive adenocarcinoma(18;0.00252)			GTTTCAAGGGGCACTCTGGAA	0.622			NA											15	32					9.16793e-09	2.3394e-08	0.00499	1	0
SRGAP3	9901	broad.mit.edu	37	3	9036109	9036109	+	Missense_Mutation	SNP	G	G	A			TCGA-55-6986-01A-11D-1945-08	TCGA-55-6986-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5a7f3c88-ef02-4e97-8009-5622245b6a09	2d60408f-5a74-4cd1-a27e-168d1d3379e6	g.chr3:9036109G>A	uc003brf.1	-	19	3002	c.2326C>T	c.(2326-2328)CGC>TGC	p.R776C	SRGAP3_uc003brg.1_Missense_Mutation_p.R752C	NM_014850	NP_055665	O43295	SRGP2_HUMAN	SLIT-ROBO Rho GTPase activating protein 3	776	SH3.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|protein binding		SRGAP3/RAF1(4)	central_nervous_system(4)|skin(3)|urinary_tract(1)|breast(1)	9				OV - Ovarian serous cystadenocarcinoma(96;0.0563)		TCCGAGGCGCGGTGGTACAGG	0.587			NA	T	RAF1	pilocytic astrocytoma								10	55					0	0	0.006214	0	0
SLC22A13	9390	broad.mit.edu	37	3	38307442	38307442	+	Silent	SNP	C	C	T			TCGA-55-6986-01A-11D-1945-08	TCGA-55-6986-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5a7f3c88-ef02-4e97-8009-5622245b6a09	2d60408f-5a74-4cd1-a27e-168d1d3379e6	g.chr3:38307442C>T	uc003chz.3	+	1	145	c.91C>T	c.(91-93)CTG>TTG	p.L31L	SLC22A13_uc011aym.1_RNA|SLC22A13_uc011ayn.1_Silent_p.L31L	NM_004256	NP_004247	Q9Y226	S22AD_HUMAN	solute carrier family 22 (organic anion	31	Helical; (Potential).					integral to plasma membrane	organic cation transmembrane transporter activity			skin(1)	1				KIRC - Kidney renal clear cell carcinoma(284;0.0533)|Kidney(284;0.067)		TCTCAACTTCCTGTCTCCCTT	0.498			NA											7	34					0	0	0.001984	0	0
PRDM9	56979	broad.mit.edu	37	5	23527795	23527795	+	Silent	SNP	G	G	A			TCGA-55-6986-01A-11D-1945-08	TCGA-55-6986-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5a7f3c88-ef02-4e97-8009-5622245b6a09	2d60408f-5a74-4cd1-a27e-168d1d3379e6	g.chr5:23527795G>A	uc003jgo.2	+	11	2780	c.2598G>A	c.(2596-2598)GGG>GGA	p.G866G		NM_020227	NP_064612	Q9NQV7	PRDM9_HUMAN	PR domain containing 9	866	C2H2-type 14.				meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleoplasm	histone-lysine N-methyltransferase activity|nucleic acid binding|zinc ion binding			ovary(3)|large_intestine(2)|pancreas(1)	6						GGGAGTGTGGGCGGGGCTTTA	0.562			NA								HNSCC(3;0.000094)			17	88					0	0	0.008871	0	0
HAPLN1	1404	broad.mit.edu	37	5	82937403	82937403	+	Missense_Mutation	SNP	C	C	T			TCGA-55-6986-01A-11D-1945-08	TCGA-55-6986-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5a7f3c88-ef02-4e97-8009-5622245b6a09	2d60408f-5a74-4cd1-a27e-168d1d3379e6	g.chr5:82937403C>T	uc003kim.2	-	4	1048	c.977G>A	c.(976-978)AGT>AAT	p.S326N	HAPLN1_uc003kin.2_Missense_Mutation_p.S326N	NM_001884	NP_001875	P10915	HPLN1_HUMAN	hyaluronan and proteoglycan link protein 1	326	Link 2.				cell adhesion	proteinaceous extracellular matrix	hyaluronic acid binding			large_intestine(3)|ovary(1)|skin(1)	5		Lung NSC(167;0.0484)|all_lung(232;0.0522)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;7.82e-42)|Epithelial(54;5.88e-35)|all cancers(79;1.14e-29)		CTCAGTAGGACTGCAGCGCCT	0.537			NA											34	105					0	0	0.010818	0	0
DNAH8	1769	broad.mit.edu	37	6	38998146	38998146	+	Missense_Mutation	SNP	C	C	A			TCGA-55-6986-01A-11D-1945-08	TCGA-55-6986-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5a7f3c88-ef02-4e97-8009-5622245b6a09	2d60408f-5a74-4cd1-a27e-168d1d3379e6	g.chr6:38998146C>A	uc003ooe.1	+	91	14051	c.13451C>A	c.(13450-13452)GCC>GAC	p.A4484D		NM_001371	NP_001362			dynein, axonemal, heavy polypeptide 8											skin(8)|ovary(7)|lung(2)|large_intestine(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	21						AGAGGAGTGGCCCTTTTGTGT	0.478			NA											4	42					1.024e-07	2.52587e-07	0.014758	1	0
SLC22A1	6580	broad.mit.edu	37	6	160575836	160575836	+	Silent	SNP	C	C	T			TCGA-55-6986-01A-11D-1945-08	TCGA-55-6986-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5a7f3c88-ef02-4e97-8009-5622245b6a09	2d60408f-5a74-4cd1-a27e-168d1d3379e6	g.chr6:160575836C>T	uc003qtc.2	+	9	1497	c.1392C>T	c.(1390-1392)CTC>CTT	p.L464L	SLC22A1_uc003qtd.2_Intron	NM_003057	NP_003048	O15245	S22A1_HUMAN	solute carrier family 22 member 1 isoform a	464	Cytoplasmic (Potential).					basolateral plasma membrane|integral to plasma membrane|membrane fraction	organic cation transmembrane transporter activity|protein binding				0		Breast(66;0.000776)|Ovarian(120;0.00556)		OV - Ovarian serous cystadenocarcinoma(65;2.73e-17)|BRCA - Breast invasive adenocarcinoma(81;1.1e-06)		TCAGGAACCTCGGAGTGATGG	0.438			NA											6	21					0	0	0.001168	0	0
CYP3A4	1576	broad.mit.edu	37	7	99359829	99359829	+	Missense_Mutation	SNP	G	G	A	rs67784355	byFrequency	TCGA-55-6986-01A-11D-1945-08	TCGA-55-6986-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5a7f3c88-ef02-4e97-8009-5622245b6a09	2d60408f-5a74-4cd1-a27e-168d1d3379e6	g.chr7:99359829G>A	uc003urv.1	-	11	1192	c.1088C>T	c.(1087-1089)ACG>ATG	p.T363M	CYP3A4_uc003urw.1_Missense_Mutation_p.T362M|CYP3A4_uc011kiz.1_Missense_Mutation_p.T322M|CYP3A4_uc011kja.1_Missense_Mutation_p.T314M|CYP3A4_uc011kjb.1_Missense_Mutation_p.T213M	NM_017460	NP_059488	P08684	CP3A4_HUMAN	cytochrome P450, family 3, subfamily A,	363			T -> M (in allele CYP3A4*11; unstable form).		alkaloid catabolic process|androgen metabolic process|exogenous drug catabolic process|heterocycle metabolic process|monoterpenoid metabolic process|oxidative demethylation|steroid catabolic process|xenobiotic metabolic process	cell surface|endoplasmic reticulum membrane|integral to membrane|microsome	albendazole monooxygenase activity|caffeine oxidase activity|electron carrier activity|enzyme binding|heme binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen|oxygen binding|quinine 3-monooxygenase activity|steroid binding|taurochenodeoxycholate 6alpha-hydroxylase activity|testosterone 6-beta-hydroxylase activity|vitamin D 24-hydroxylase activity|vitamin D3 25-hydroxylase activity			central_nervous_system(3)|ovary(1)	4	Lung NSC(181;0.0144)|Esophageal squamous(72;0.0166)|all_lung(186;0.0228)				Albendazole(DB00518)|Alclometasone(DB00240)|Alfentanil(DB00802)|Alfuzosin(DB00346)|Aliskiren(DB01258)|Almotriptan(DB00918)|Alosetron(DB00969)|Alprazolam(DB00404)|Amlodipine(DB00381)|Amprenavir(DB00701)|Aprepitant(DB00673)|Aripiprazole(DB01238)|Astemizole(DB00637)|Atazanavir(DB01072)|Atorvastatin(DB01076)|Benazepril(DB00542)|Bepridil(DB01244)|Betamethasone(DB00443)|Bexarotene(DB00307)|Bortezomib(DB00188)|Bosentan(DB00559)|Bromocriptine(DB01200)|Budesonide(DB01222)|Bupivacaine(DB00297)|Buprenorphine(DB00921)|Buspirone(DB00490)|Busulfan(DB01008)|Carbamazepine(DB00564)|Cevimeline(DB00185)|Chlorpheniramine(DB01114)|Ciclesonide(DB01410)|Cilostazol(DB01166)|Cinacalcet(DB01012)|Cisapride(DB00604)|Clarithromycin(DB01211)|Clindamycin(DB01190)|Clofibrate(DB00636)|Clonazepam(DB01068)|Clopidogrel(DB00758)|Cocaine(DB00907)|Conivaptan(DB00872)|Conjugated Estrogens(DB00286)|Cyproterone(DB04839)|Darifenacin(DB00496)|Darunavir(DB01264)|Dasatinib(DB01254)|Delavirdine(DB00705)|Desogestrel(DB00304)|Dexamethasone(DB01234)|Diazepam(DB00829)|Dihydroergotamine(DB00320)|Diltiazem(DB00343)|Diphenhydramine(DB01075)|Disopyramide(DB00280)|Dofetilide(DB00204)|Dolasetron(DB00757)|Domperidone(DB01184)|Donepezil(DB00843)|Doxorubicin(DB00997)|Drospirenone(DB01395)|Dutasteride(DB01126)|Efavirenz(DB00625)|Eletriptan(DB00216)|Enalapril(DB00584)|Epirubicin(DB00445)|Eplerenone(DB00700)|Ergotamine(DB00696)|Erlotinib(DB00530)|Erythromycin(DB00199)|Escitalopram(DB01175)|Esomeprazole(DB00736)|Estazolam(DB01215)|Eszopiclone(DB00402)|Ethinyl Estradiol(DB00977)|Ethosuximide(DB00593)|Etonogestrel(DB00294)|Etoposide(DB00773)|Etoricoxib(DB01628)|Exemestane(DB00990)|Felodipine(DB01023)|Fentanyl(DB00813)|Fexofenadine(DB00950)|Finasteride(DB01216)|Fluconazole(DB00196)|Flumethasone Pivalate(DB00663)|Flunisolide(DB00180)|Fluocinolone Acetonide(DB00591)|Fluocinonide(DB01047)|Fluorometholone(DB00324)|Flurandrenolide(DB00846)|Fluticasone Propionate(DB00588)|Fosamprenavir(DB01319)|Fulvestrant(DB00947)|Galantamine(DB00674)|Gefitinib(DB00317)|Gemfibrozil(DB01241)|Granisetron(DB00889)|Grepafloxacin(DB00365)|Halofantrine(DB01218)|Hydrocodone(DB00956)|Hydrocortamate(DB00769)|Hydrocortisone(DB00741)|Hydromorphone(DB00327)|Imatinib(DB00619)|Indinavir(DB00224)|Ipratropium(DB00332)|Irinotecan(DB00762)|Isosorbide Dinitrate(DB00883)|Isosorbide Mononitrate(DB01020)|Isradipine(DB00270)|Itraconazole(DB01167)|Ketoconazole(DB01026)|Lapatinib(DB01259)|Lercanidipine(DB00528)|Letrozole(DB01006)|Levobupivacaine(DB01002)|Levomethadyl Acetate(DB01227)|Levothyroxine(DB00451)|Lomustine(DB01206)|Loperamide(DB00836)|Lopinavir(DB01601)|Loratadine(DB00455)|Losartan(DB00678)|Lovastatin(DB00227)|Maraviroc(DB04835)|Marinol(DB00470)|Mebendazole(DB00643)|Medroxyprogesterone(DB00603)|Methadone(DB00333)|Methylprednisolone(DB00959)|Metyrapone(DB01011)|Mibefradil(DB01388)|Midazolam(DB00683)|Mifepristone(DB00834)|Mirtazapine(DB00370)|Modafinil(DB00745)|Mometasone(DB00764)|Montelukast(DB00471)|Nateglinide(DB00731)|Nefazodone(DB01149)|Nelfinavir(DB00220)|Nevirapine(DB00238)|Nicardipine(DB00622)|Nifedipine(DB01115)|Nimodipine(DB00393)|Nisoldipine(DB00401)|Nitrendipine(DB01054)|Norethindrone(DB00717)|Norgestrel(DB00506)|Nystatin(DB00646)|Ondansetron(DB00904)|Oxybutynin(DB01062)|Paclitaxel(DB01229)|Paliperidone(DB01267)|Palonosetron(DB00377)|Pantoprazole(DB00213)|Paricalcitol(DB00910)|Phenmetrazine(DB00830)|Pimecrolimus(DB00337)|Pimozide(DB01100)|Pioglitazone(DB01132)|Posaconazole(DB01263)|Pranlukast(DB01411)|Prednisolone(DB00860)|Prednisone(DB00635)|Prochlorperazine(DB00433)|Quetiapine(DB01224)|Quinapril(DB00881)|Quinine(DB00468)|Rabeprazole(DB01129)|Ranolazine(DB00243)|Reboxetine(DB00234)|Retapamulin(DB01256)|Rifabutin(DB00615)|Rifampin(DB01045)|Rimonabant(DB06155)|Ritonavir(DB00503)|Rofecoxib(DB00533)|Roxithromycin(DB00778)|Salmeterol(DB00938)|Saquinavir(DB01232)|Sertindole(DB06144)|Sibutramine(DB01105)|Simvastatin(DB00641)|Sirolimus(DB00877)|Sitagliptin(DB01261)|Solifenacin(DB01591)|Sorafenib(DB00398)|Sunitinib(DB01268)|Tacrolimus(DB00864)|Tadalafil(DB00820)|Tamoxifen(DB00675)|Telithromycin(DB00976)|Terconazole(DB00251)|Terfenadine(DB00342)|Testosterone(DB00624)|Tiagabine(DB00906)|Ticlopidine(DB00208)|Tinidazole(DB00911)|Tiotropium(DB01409)|Tipranavir(DB00932)|Toremifene(DB00539)|Triazolam(DB00897)|Trimetrexate(DB01157)|Troglitazone(DB00197)|Valdecoxib(DB00580)|Vardenafil(DB00862)|Vinblastine(DB00570)|Vincristine(DB00541)|Vindesine(DB00309)|Vinorelbine(DB00361)|Voriconazole(DB00582)|Zaleplon(DB00962)|Zileuton(DB00744)|Ziprasidone(DB00246)|Zolpidem(DB00425)|Zonisamide(DB00909)	TAATCTGAGCGTTTCATTCAC	0.418			NA											6	37					0	0	0.001168	0	0
ACER2	340485	broad.mit.edu	37	9	19424785	19424785	+	Missense_Mutation	SNP	C	C	T			TCGA-55-6986-01A-11D-1945-08	TCGA-55-6986-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5a7f3c88-ef02-4e97-8009-5622245b6a09	2d60408f-5a74-4cd1-a27e-168d1d3379e6	g.chr9:19424785C>T	uc003zny.1	+	3	469	c.311C>T	c.(310-312)GCT>GTT	p.A104V	ACER2_uc003znx.1_RNA|ACER2_uc003znz.1_Missense_Mutation_p.A55V	NM_001010887	NP_001010887	Q5QJU3	ACER2_HUMAN	alkaline ceramidase 2	104	Helical; (Potential).				ceramide metabolic process|negative regulation of cell adhesion mediated by integrin|negative regulation of cell-matrix adhesion|negative regulation of protein glycosylation in Golgi|positive regulation of cell proliferation|response to retinoic acid|sphingosine biosynthetic process	integral to Golgi membrane	ceramidase activity			haematopoietic_and_lymphoid_tissue(1)|skin(1)	2						CTGATGTGTGCTTTGGCCATG	0.438			NA											9	52					0	0	0.004482	0	0
SETD2	29072	broad.mit.edu	37	3	47125651	47125651	+	Frame_Shift_Del	DEL	G	G	-			TCGA-55-6986-01A-11D-1945-08	TCGA-55-6986-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5a7f3c88-ef02-4e97-8009-5622245b6a09	2d60408f-5a74-4cd1-a27e-168d1d3379e6	g.chr3:47125651delG	uc003cqs.2	-	12	5672	c.5619delC	c.(5617-5619)CCCfs	p.P1873fs	SETD2_uc003cqv.2_Frame_Shift_Del_p.P1940fs|SETD2_uc003cqt.1_RNA	NM_014159	NP_054878	Q9BYW2	SETD2_HUMAN	SET domain containing 2	1873					regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	DNA binding|histone-lysine N-methyltransferase activity|oxidoreductase activity|transition metal ion binding	p.L1873fs*50(1)		kidney(24)|ovary(5)|skin(1)|central_nervous_system(1)|breast(1)	32		Acute lymphoblastic leukemia(5;0.0169)		BRCA - Breast invasive adenocarcinoma(193;0.000302)|KIRC - Kidney renal clear cell carcinoma(197;0.00732)|Kidney(197;0.00844)		TTAGTTTCTTGGGAGTGTCTG	0.453			NA	N|F|S|Mis		clear cell renal carcinoma								12	73	---	---	---	---	NA	NA	NA	NA	NA
SETD2	29072	broad.mit.edu	37	3	47155477	47155478	+	Frame_Shift_Del	DEL	TT	TT	-			TCGA-55-6986-01A-11D-1945-08	TCGA-55-6986-11A-01D-1945-08	TT	TT	-	-	TT	TT	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5a7f3c88-ef02-4e97-8009-5622245b6a09	2d60408f-5a74-4cd1-a27e-168d1d3379e6	g.chr3:47155477_47155478delTT	uc003cqs.2	-	5	4656_4657	c.4603_4604delAA	c.(4603-4605)AATfs	p.N1535fs	SETD2_uc003cqv.2_Frame_Shift_Del_p.N1524fs	NM_014159	NP_054878	Q9BYW2	SETD2_HUMAN	SET domain containing 2	1535	AWS.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	DNA binding|histone-lysine N-methyltransferase activity|oxidoreductase activity|transition metal ion binding			kidney(24)|ovary(5)|skin(1)|central_nervous_system(1)|breast(1)	32		Acute lymphoblastic leukemia(5;0.0169)		BRCA - Breast invasive adenocarcinoma(193;0.000302)|KIRC - Kidney renal clear cell carcinoma(197;0.00732)|Kidney(197;0.00844)		ATAATCCCCATTTGGACACCGA	0.376			NA	N|F|S|Mis		clear cell renal carcinoma								11	68	---	---	---	---	NA	NA	NA	NA	NA
MED23	9439	broad.mit.edu	37	6	131919786	131919787	+	Frame_Shift_Ins	INS	-	-	G			TCGA-55-6986-01A-11D-1945-08	TCGA-55-6986-11A-01D-1945-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5a7f3c88-ef02-4e97-8009-5622245b6a09	2d60408f-5a74-4cd1-a27e-168d1d3379e6	g.chr6:131919786_131919787insG	uc003qcs.1	-	19	2509_2510	c.2335_2336insC	c.(2335-2337)CACfs	p.H779fs	MED23_uc003qcq.2_Frame_Shift_Ins_p.H785fs|MED23_uc011eca.1_Frame_Shift_Ins_p.H420fs|MED23_uc003qct.1_Frame_Shift_Ins_p.H785fs	NM_004830	NP_004821	Q9ULK4	MED23_HUMAN	mediator complex subunit 23 isoform a	779					regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	transcription factor complex	protein binding|transcription coactivator activity			ovary(1)|kidney(1)|central_nervous_system(1)	3	Breast(56;0.0753)			GBM - Glioblastoma multiforme(226;0.0115)|OV - Ovarian serous cystadenocarcinoma(155;0.0608)		CATAGAGAAGTGGGTAATAATG	0.396			NA											7	26	---	---	---	---	NA	NA	NA	NA	NA