Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	ACHILLES_Top_Genes	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
CAMTA1	23261	broad.mit.edu	37	1	7700570	7700570	+	Silent	SNP	G	G	A			TCGA-50-6673-01A-11D-1945-08	TCGA-50-6673-11A-02D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc6185f2-f1ea-43ea-8d4f-3b121949d06f	20683d9f-102f-4976-985f-97162ae99514	g.chr1:7700570G>A	uc001aoi.2	+	7	828	c.621G>A	c.(619-621)GCG>GCA	p.A207A		NM_015215	NP_056030	Q9Y6Y1	CMTA1_HUMAN	calmodulin-binding transcription activator 1	207					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	calmodulin binding			ovary(5)|central_nervous_system(2)|breast(1)|pancreas(1)	9	Ovarian(185;0.0634)	all_epithelial(116;8.38e-23)|all_lung(118;5.87e-07)|Lung NSC(185;3.43e-06)|Renal(390;0.000219)|Breast(487;0.000307)|Colorectal(325;0.000615)|Hepatocellular(190;0.0088)|Myeloproliferative disorder(586;0.0303)|Ovarian(437;0.0388)		UCEC - Uterine corpus endometrioid carcinoma (279;0.101)|Colorectal(212;1.33e-05)|COAD - Colon adenocarcinoma(227;0.000235)|BRCA - Breast invasive adenocarcinoma(304;0.000864)|Kidney(185;0.00244)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0179)|READ - Rectum adenocarcinoma(331;0.133)		AGGAGTGGGCGAAATGGACGA	0.627			NA											27	73					0	0	0.001512	0	0
NBPF1	55672	broad.mit.edu	37	1	16918653	16918653	+	Splice_Site	SNP	C	C	T			TCGA-50-6673-01A-11D-1945-08	TCGA-50-6673-11A-02D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc6185f2-f1ea-43ea-8d4f-3b121949d06f	20683d9f-102f-4976-985f-97162ae99514	g.chr1:16918653C>T	uc009vos.1	-	6	853	c.-35_splice	c.e6+1		NBPF1_uc010oce.1_Intron	NM_017940	NP_060410	Q3BBV0	NBPF1_HUMAN	hypothetical protein LOC55672							cytoplasm					0				UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.52e-06)|COAD - Colon adenocarcinoma(227;1.05e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.179)		TCTTAACTTACTGTTGTGAAA	0.418			NA											6	42					0	0	0.00116845	0	0
NIPAL3	57185	broad.mit.edu	37	1	24786997	24786997	+	Missense_Mutation	SNP	G	G	T			TCGA-50-6673-01A-11D-1945-08	TCGA-50-6673-11A-02D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc6185f2-f1ea-43ea-8d4f-3b121949d06f	20683d9f-102f-4976-985f-97162ae99514	g.chr1:24786997G>T	uc001bjh.2	+	10	1296	c.889G>T	c.(889-891)GGG>TGG	p.G297W	NIPAL3_uc001bjg.2_Missense_Mutation_p.G297W|NIPAL3_uc009vrc.2_Missense_Mutation_p.G215W|NIPAL3_uc001bji.2_Missense_Mutation_p.R105L	NM_020448	NP_065181	Q6P499	NPAL3_HUMAN	NIPA-like domain containing 3	297						integral to membrane					0						GGACTTCATCGGGGAGGACGT	0.493			NA											4	54					8.12818e-05	0.000441558	8.12818e-05	1	0
ZNF644	84146	broad.mit.edu	37	1	91403507	91403507	+	Missense_Mutation	SNP	G	G	T			TCGA-50-6673-01A-11D-1945-08	TCGA-50-6673-11A-02D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc6185f2-f1ea-43ea-8d4f-3b121949d06f	20683d9f-102f-4976-985f-97162ae99514	g.chr1:91403507G>T	uc001dnw.2	-	4	3365	c.3223C>A	c.(3223-3225)CCA>ACA	p.P1075T	ZNF644_uc001dnv.2_Intron|ZNF644_uc001dnx.2_Intron	NM_201269	NP_958357	Q9H582	ZN644_HUMAN	zinc finger protein 644 isoform 1	1075					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|breast(1)|skin(1)	3		all_lung(203;0.00206)|Lung NSC(277;0.0519)|Lung SC(238;0.101)		all cancers(265;0.00102)|Epithelial(280;0.00766)|KIRC - Kidney renal clear cell carcinoma(1967;0.147)|OV - Ovarian serous cystadenocarcinoma(397;0.173)		ACACAGATTGGAGATTTGTGA	0.368			NA											6	103					2.7689e-08	1.63691e-07	8.12818e-05	1	0
ST7L	54879	broad.mit.edu	37	1	113124662	113124662	+	Missense_Mutation	SNP	C	C	G			TCGA-50-6673-01A-11D-1945-08	TCGA-50-6673-11A-02D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc6185f2-f1ea-43ea-8d4f-3b121949d06f	20683d9f-102f-4976-985f-97162ae99514	g.chr1:113124662C>G	uc001ecd.2	-	9	1326	c.1021G>C	c.(1021-1023)GAA>CAA	p.E341Q	ST7L_uc009wgh.2_Intron|ST7L_uc001ecc.2_Missense_Mutation_p.E158Q|ST7L_uc010owg.1_Missense_Mutation_p.E276Q|ST7L_uc010owh.1_Intron|ST7L_uc001ece.2_Missense_Mutation_p.E341Q|ST7L_uc001ecf.2_Missense_Mutation_p.E324Q|ST7L_uc001ecg.2_RNA|ST7L_uc010owi.1_Missense_Mutation_p.E276Q|ST7L_uc001ech.2_Missense_Mutation_p.E324Q|ST7L_uc001eci.2_Missense_Mutation_p.E341Q|ST7L_uc009wgi.1_RNA|ST7L_uc010owj.1_Missense_Mutation_p.E324Q	NM_017744	NP_060214	Q8TDW4	ST7L_HUMAN	suppression of tumorigenicity 7-like isoform 1	341					negative regulation of cell growth	integral to membrane	binding				0	Lung SC(450;0.246)	all_cancers(81;1.44e-07)|all_epithelial(167;7.64e-07)|all_lung(203;2.16e-05)|Lung NSC(69;3.86e-05)		Lung(183;0.0234)|all cancers(265;0.0246)|Epithelial(280;0.0342)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		GCCTGTAATTCTAAAAGTGAT	0.328			NA											3	62					0	0	0.00024832	0	0
ANKRD34A	284615	broad.mit.edu	37	1	145474307	145474307	+	Missense_Mutation	SNP	T	T	G			TCGA-50-6673-01A-11D-1945-08	TCGA-50-6673-11A-02D-1945-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc6185f2-f1ea-43ea-8d4f-3b121949d06f	20683d9f-102f-4976-985f-97162ae99514	g.chr1:145474307T>G	uc001enq.1	+	4	2272	c.979T>G	c.(979-981)TCA>GCA	p.S327A	NBPF10_uc001emp.3_Intron|LIX1L_uc001enr.2_5'Flank	NM_001039888	NP_001034977	Q69YU3	AN34A_HUMAN	ankyrin repeat domain 34	327	Pro-rich.										0	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					TGGTCCCCCTTCAGGGCTGAG	0.647			NA											14	24					0	0	0.000308642	0	0
OR10J3	441911	broad.mit.edu	37	1	159283480	159283480	+	Missense_Mutation	SNP	C	C	T			TCGA-50-6673-01A-11D-1945-08	TCGA-50-6673-11A-02D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc6185f2-f1ea-43ea-8d4f-3b121949d06f	20683d9f-102f-4976-985f-97162ae99514	g.chr1:159283480C>T	uc010piu.1	-	1	970	c.970G>A	c.(970-972)GCG>ACG	p.A324T		NM_001004467	NP_001004467	Q5JRS4	O10J3_HUMAN	olfactory receptor, family 10, subfamily J,	324	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	all_hematologic(112;0.0429)					TTTATAAACGCAAAGGAAAAG	0.393			NA											15	65					0	0	0.000308642	0	0
GPR52	9293	broad.mit.edu	37	1	174418031	174418031	+	Missense_Mutation	SNP	G	G	A	rs144653948		TCGA-50-6673-01A-11D-1945-08	TCGA-50-6673-11A-02D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc6185f2-f1ea-43ea-8d4f-3b121949d06f	20683d9f-102f-4976-985f-97162ae99514	g.chr1:174418031G>A	uc001gka.1	+	1	820	c.782G>A	c.(781-783)CGT>CAT	p.R261H	RABGAP1L_uc001gjw.2_Intron|RABGAP1L_uc001gjx.2_Intron|RABGAP1L_uc001gjy.2_Intron|RABGAP1L_uc001gjz.2_Intron|uc010pmu.1_RNA	NM_005684	NP_005675	Q9Y2T5	GPR52_HUMAN	G protein-coupled receptor 52	261	Cytoplasmic (Potential).					integral to plasma membrane	G-protein coupled receptor activity			skin(1)	1						AGCCCTGACCGTCGCTACGCC	0.458	Ovarian(92;924 1390 1930 16467 40583)		NA											30	74					0	0	0.001512	0	0
PAPPA2	60676	broad.mit.edu	37	1	176668708	176668708	+	Missense_Mutation	SNP	C	C	A			TCGA-50-6673-01A-11D-1945-08	TCGA-50-6673-11A-02D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc6185f2-f1ea-43ea-8d4f-3b121949d06f	20683d9f-102f-4976-985f-97162ae99514	g.chr1:176668708C>A	uc001gkz.2	+	8	4383	c.3219C>A	c.(3217-3219)CAC>CAA	p.H1073Q	PAPPA2_uc009www.2_RNA	NM_020318	NP_064714	Q9BXP8	PAPP2_HUMAN	pappalysin 2 isoform 1	1073					cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			ovary(7)|central_nervous_system(5)|skin(2)|lung(1)|breast(1)	16						CACATTCTCACAGGAAGTTCA	0.542			NA											14	193					2.31682e-05	0.000129356	0.000308642	1	0
CRB1	23418	broad.mit.edu	37	1	197316538	197316538	+	Nonsense_Mutation	SNP	G	G	A			TCGA-50-6673-01A-11D-1945-08	TCGA-50-6673-11A-02D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc6185f2-f1ea-43ea-8d4f-3b121949d06f	20683d9f-102f-4976-985f-97162ae99514	g.chr1:197316538G>A	uc001gtz.2	+	4	1052	c.917G>A	c.(916-918)TGG>TAG	p.W306*	CRB1_uc010poz.1_Nonsense_Mutation_p.W237*|CRB1_uc001gty.1_Nonsense_Mutation_p.W306*|CRB1_uc010ppa.1_RNA|CRB1_uc009wza.2_Intron|CRB1_uc010ppb.1_Nonsense_Mutation_p.W306*|CRB1_uc010ppc.1_RNA	NM_201253	NP_957705	P82279	CRUM1_HUMAN	crumbs homolog 1 precursor	306	Extracellular (Potential).|EGF-like 8.				cell-cell signaling|establishment or maintenance of cell polarity	apical plasma membrane|extracellular region|integral to membrane	calcium ion binding|protein binding			ovary(5)|skin(3)|large_intestine(1)	9						CCTCTTTGTTGGTCAAAACCT	0.423			NA											23	61					0	0	0.000375601	0	0
ATP2B4	493	broad.mit.edu	37	1	203668679	203668679	+	Silent	SNP	C	C	T			TCGA-50-6673-01A-11D-1945-08	TCGA-50-6673-11A-02D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc6185f2-f1ea-43ea-8d4f-3b121949d06f	20683d9f-102f-4976-985f-97162ae99514	g.chr1:203668679C>T	uc001gzw.2	+	4	1367	c.483C>T	c.(481-483)ATC>ATT	p.I161I	ATP2B4_uc001gzv.2_Silent_p.I161I|ATP2B4_uc009xaq.2_Silent_p.I161I	NM_001684	NP_001675	P23634	AT2B4_HUMAN	plasma membrane calcium ATPase 4 isoform 4b	161	Helical; (Potential).				ATP biosynthetic process|platelet activation	integral to plasma membrane	ATP binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding|protein binding			ovary(2)|skin(1)	3	all_cancers(21;0.071)|all_epithelial(62;0.228)		BRCA - Breast invasive adenocarcinoma(75;0.109)			CAGTGATCATCGTGGTGTTAG	0.502			NA											11	193					0	0	0.00136819	0	0
GBF1	8729	broad.mit.edu	37	10	104112253	104112253	+	Missense_Mutation	SNP	A	A	G			TCGA-50-6673-01A-11D-1945-08	TCGA-50-6673-11A-02D-1945-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc6185f2-f1ea-43ea-8d4f-3b121949d06f	20683d9f-102f-4976-985f-97162ae99514	g.chr10:104112253A>G	uc001kux.1	+	7	802	c.562A>G	c.(562-564)ATG>GTG	p.M188V	GBF1_uc001kuw.2_Missense_Mutation_p.M188V|GBF1_uc001kuy.1_Missense_Mutation_p.M188V|GBF1_uc001kuz.1_Missense_Mutation_p.M188V	NM_004193	NP_004184	Q92538	GBF1_HUMAN	golgi-specific brefeldin A resistant guanine	188					COPI coating of Golgi vesicle|post-Golgi vesicle-mediated transport|regulation of ARF protein signal transduction|retrograde vesicle-mediated transport, Golgi to ER	Golgi membrane	ARF guanyl-nucleotide exchange factor activity|protein binding			ovary(1)|central_nervous_system(1)	2		Colorectal(252;0.0236)		Epithelial(162;5.16e-08)|all cancers(201;1.19e-06)		TCTCGTAGACATGGTGCAGCT	0.507			NA									OREG0020477	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	12	56					0	0	0.00185496	0	0
TACC2	10579	broad.mit.edu	37	10	123845072	123845072	+	Missense_Mutation	SNP	A	A	T			TCGA-50-6673-01A-11D-1945-08	TCGA-50-6673-11A-02D-1945-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc6185f2-f1ea-43ea-8d4f-3b121949d06f	20683d9f-102f-4976-985f-97162ae99514	g.chr10:123845072A>T	uc001lfv.2	+	4	3417	c.3057A>T	c.(3055-3057)GAA>GAT	p.E1019D	TACC2_uc001lfw.2_Intron|TACC2_uc009xzx.2_Missense_Mutation_p.E1019D|TACC2_uc010qtv.1_Missense_Mutation_p.E1019D	NM_206862	NP_996744	O95359	TACC2_HUMAN	transforming, acidic coiled-coil containing	1019						microtubule organizing center|nucleus	nuclear hormone receptor binding			ovary(4)|breast(3)|skin(2)|central_nervous_system(1)	10		all_neural(114;0.0656)|Lung NSC(174;0.136)|all_lung(145;0.17)|Breast(234;0.197)				GAGCTTCTGAAGCAGCTGATG	0.557			NA											6	40					0	0	0.00116845	0	0
OR52N1	79473	broad.mit.edu	37	11	5809217	5809217	+	Missense_Mutation	SNP	A	A	T			TCGA-50-6673-01A-11D-1945-08	TCGA-50-6673-11A-02D-1945-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc6185f2-f1ea-43ea-8d4f-3b121949d06f	20683d9f-102f-4976-985f-97162ae99514	g.chr11:5809217A>T	uc010qzo.1	-	1	830	c.830T>A	c.(829-831)ATT>AAT	p.I277N	TRIM5_uc001mbq.1_Intron|TRIM22_uc009yet.1_Intron	NM_001001913	NP_001001913	Q8NH53	O52N1_HUMAN	olfactory receptor, family 52, subfamily N,	277	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;3.05e-11)|LUSC - Lung squamous cell carcinoma(625;0.112)|BRCA - Breast invasive adenocarcinoma(625;0.135)|Lung(200;0.195)		AGCCATAATAATATGTATGTG	0.438			NA											12	52					0	0	0.00185496	0	0
ARAP1	116985	broad.mit.edu	37	11	72408407	72408407	+	Missense_Mutation	SNP	C	C	T			TCGA-50-6673-01A-11D-1945-08	TCGA-50-6673-11A-02D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc6185f2-f1ea-43ea-8d4f-3b121949d06f	20683d9f-102f-4976-985f-97162ae99514	g.chr11:72408407C>T	uc001osu.2	-	21	3103	c.2914G>A	c.(2914-2916)GTG>ATG	p.V972M	ARAP1_uc001osv.2_Missense_Mutation_p.V972M|ARAP1_uc001osr.2_Missense_Mutation_p.V732M|ARAP1_uc001oss.2_Missense_Mutation_p.V727M|ARAP1_uc009yth.2_Missense_Mutation_p.V666M|ARAP1_uc010rre.1_Missense_Mutation_p.V727M	NM_001040118	NP_001035207	Q96P48	ARAP1_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH	972	Rho-GAP.				actin filament reorganization involved in cell cycle|negative regulation of stress fiber assembly|positive regulation of Cdc42 GTPase activity|positive regulation of filopodium assembly|regulation of ARF GTPase activity|regulation of cell shape|regulation of cellular component movement|small GTPase mediated signal transduction	cytosol|Golgi cisterna membrane|plasma membrane	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|protein binding|Rho GTPase activator activity|zinc ion binding			skin(1)	1						TACACGATCACCGGGATATCC	0.682	Ovarian(102;1198 1520 13195 17913 37529)		NA											4	14					0	0	0.000602214	0	0
NUP107	57122	broad.mit.edu	37	12	69107517	69107517	+	Missense_Mutation	SNP	A	A	G			TCGA-50-6673-01A-11D-1945-08	TCGA-50-6673-11A-02D-1945-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc6185f2-f1ea-43ea-8d4f-3b121949d06f	20683d9f-102f-4976-985f-97162ae99514	g.chr12:69107517A>G	uc001suf.2	+	11	1013	c.898A>G	c.(898-900)ACT>GCT	p.T300A	NUP107_uc001sug.2_Missense_Mutation_p.T147A|NUP107_uc010stj.1_Missense_Mutation_p.T271A	NM_020401	NP_065134	P57740	NU107_HUMAN	nucleoporin 107kDa	300					carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA export from nucleus|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytosol|Nup107-160 complex	nucleocytoplasmic transporter activity|protein binding			skin(1)	1	Breast(13;6.25e-06)		Lung(24;0.000131)|LUAD - Lung adenocarcinoma(15;0.00107)|STAD - Stomach adenocarcinoma(21;0.00694)			CAGGGAAAATACTCTGCATAC	0.328			NA											14	45					0	0	0.000219431	0	0
DHX37	57647	broad.mit.edu	37	12	125434579	125434579	+	Silent	SNP	C	C	G			TCGA-50-6673-01A-11D-1945-08	TCGA-50-6673-11A-02D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc6185f2-f1ea-43ea-8d4f-3b121949d06f	20683d9f-102f-4976-985f-97162ae99514	g.chr12:125434579C>G	uc001ugy.2	-	25	3342	c.3243G>C	c.(3241-3243)CGG>CGC	p.R1081R	DHX37_uc001ugz.1_Silent_p.R168R	NM_032656	NP_116045	Q8IY37	DHX37_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 37	1081							ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			skin(1)	1	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;8.05e-05)|Epithelial(86;0.000486)|all cancers(50;0.00653)		GCAGACAGCTCCGGTATGAGG	0.662			NA											8	15					0	0	0.000157383	0	0
GPR180	160897	broad.mit.edu	37	13	95271525	95271525	+	Silent	SNP	G	G	C			TCGA-50-6673-01A-11D-1945-08	TCGA-50-6673-11A-02D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc6185f2-f1ea-43ea-8d4f-3b121949d06f	20683d9f-102f-4976-985f-97162ae99514	g.chr13:95271525G>C	uc001vly.2	+	4	705	c.627G>C	c.(625-627)CTG>CTC	p.L209L	GPR180_uc001vlz.2_Silent_p.L108L|GPR180_uc010afi.2_Intron	NM_180989	NP_851320	Q86V85	GP180_HUMAN	G protein-coupled receptor 180 precursor	209	Helical; (Potential).					integral to membrane				breast(1)	1	all_neural(89;0.0684)|Medulloblastoma(90;0.163)					TAAAGGTTCTGACAACTGCAT	0.388			NA											3	75					0	0	6.4e-05	0	0
FOXG1	2290	broad.mit.edu	37	14	29237174	29237174	+	Missense_Mutation	SNP	G	G	A			TCGA-50-6673-01A-11D-1945-08	TCGA-50-6673-11A-02D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc6185f2-f1ea-43ea-8d4f-3b121949d06f	20683d9f-102f-4976-985f-97162ae99514	g.chr14:29237174G>A	uc001wqe.2	+	1	888	c.689G>A	c.(688-690)CGC>CAC	p.R230H		NM_005249	NP_005240	P55316	FOXG1_HUMAN	forkhead box G1	230	Fork-head.				axon midline choice point recognition|central nervous system neuron development|dorsal/ventral pattern formation|embryo development ending in birth or egg hatching|hindbrain development|inner ear morphogenesis|negative regulation of neuron differentiation|negative regulation of transcription, DNA-dependent|nonmotile primary cilium assembly|nose development|positive regulation of cell cycle|positive regulation of neuroblast proliferation|positive regulation of transcription from RNA polymerase II promoter|regulation of mitotic cell cycle|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			ovary(2)|lung(2)	4			LUAD - Lung adenocarcinoma(48;0.011)|Lung(238;0.0575)	GBM - Glioblastoma multiforme(265;0.00413)		AACTCCATCCGCCACAATCTG	0.592			NA											16	30					0	0	0.000566183	0	0
PLEKHG3	26030	broad.mit.edu	37	14	65208417	65208417	+	Missense_Mutation	SNP	G	G	A			TCGA-50-6673-01A-11D-1945-08	TCGA-50-6673-11A-02D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc6185f2-f1ea-43ea-8d4f-3b121949d06f	20683d9f-102f-4976-985f-97162ae99514	g.chr14:65208417G>A	uc001xho.1	+	16	2451	c.2182G>A	c.(2182-2184)GAA>AAA	p.E728K	PLEKHG3_uc001xhn.1_Missense_Mutation_p.E672K|PLEKHG3_uc001xhp.2_Missense_Mutation_p.E849K|PLEKHG3_uc010aqh.1_Missense_Mutation_p.E270K|PLEKHG3_uc001xhq.1_Missense_Mutation_p.E233K	NM_015549	NP_056364	A1L390	PKHG3_HUMAN	pleckstrin homology domain containing, family G,	728				YYENAEHHDAGFSV -> WWPHCTPASCSSPT (in Ref. 2; AAH04298).	regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			skin(1)	1				all cancers(60;0.00802)|OV - Ovarian serous cystadenocarcinoma(108;0.0109)|BRCA - Breast invasive adenocarcinoma(234;0.0485)		TGAAAATGCAGAACACCATGA	0.527			NA											36	92					0	0	0.00111076	0	0
RPAP1	26015	broad.mit.edu	37	15	41813100	41813100	+	Missense_Mutation	SNP	G	G	A	rs138581766		TCGA-50-6673-01A-11D-1945-08	TCGA-50-6673-11A-02D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc6185f2-f1ea-43ea-8d4f-3b121949d06f	20683d9f-102f-4976-985f-97162ae99514	g.chr15:41813100G>A	uc001zod.2	-	22	3408	c.3284C>T	c.(3283-3285)CCG>CTG	p.P1095L	RPAP1_uc001zoc.2_Missense_Mutation_p.P114L	NM_015540	NP_056355	Q9BWH6	RPAP1_HUMAN	RNA polymerase II associated protein 1	1095	Leu-rich.					nucleus	DNA binding|DNA-directed RNA polymerase activity			large_intestine(1)	1		all_cancers(109;6.59e-20)|all_epithelial(112;7.67e-17)|Lung NSC(122;5.34e-11)|all_lung(180;4.17e-10)|Melanoma(134;0.0179)|Ovarian(310;0.143)|Colorectal(260;0.173)		OV - Ovarian serous cystadenocarcinoma(18;2.84e-17)|GBM - Glioblastoma multiforme(113;1.68e-06)|Colorectal(105;0.0163)|BRCA - Breast invasive adenocarcinoma(123;0.117)		GGGCAGCAGCGGCTCCGTAGG	0.662			NA											7	54					0	0	8.12818e-05	0	0
SHCBP1	79801	broad.mit.edu	37	16	46615942	46615942	+	Missense_Mutation	SNP	G	G	C			TCGA-50-6673-01A-11D-1945-08	TCGA-50-6673-11A-02D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc6185f2-f1ea-43ea-8d4f-3b121949d06f	20683d9f-102f-4976-985f-97162ae99514	g.chr16:46615942G>C	uc002eec.3	-	13	1758	c.1718C>G	c.(1717-1719)ACA>AGA	p.T573R		NM_024745	NP_079021	Q8NEM2	SHCBP_HUMAN	SHC SH2-domain binding protein 1	573										ovary(1)|breast(1)	2		all_cancers(37;0.00404)|all_epithelial(9;0.00527)|all_lung(18;0.0413)|Lung NSC(13;0.213)				CTCTCCACTTGTCTGAATTTT	0.373			NA											17	88					0	0	0.00121646	0	0
TP53	7157	broad.mit.edu	37	17	7574018	7574018	+	Missense_Mutation	SNP	G	G	A			TCGA-50-6673-01A-11D-1945-08	TCGA-50-6673-11A-02D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc6185f2-f1ea-43ea-8d4f-3b121949d06f	20683d9f-102f-4976-985f-97162ae99514	g.chr17:7574018G>A	uc002gim.2	-	10	1203	c.1009C>T	c.(1009-1011)CGC>TGC	p.R337C	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Intron|TP53_uc010cne.1_Intron|TP53_uc010cnf.1_3'UTR|TP53_uc010cng.1_3'UTR|TP53_uc002gii.1_Missense_Mutation_p.R205C|TP53_uc010cnh.1_3'UTR|TP53_uc010cni.1_3'UTR|TP53_uc002gij.2_Missense_Mutation_p.R337C	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	337	Oligomerization.|Interaction with HIPK1 (By similarity).|Interaction with CARM1.|Interaction with HIPK2.		R -> H (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> P (in sporadic cancers; somatic mutation).|R -> C (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> L (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R337C(12)|p.0?(7)|p.R337L(5)|p.R337H(2)|p.?(1)|p.I332fs*5(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		ATCTCGAAGCGCTCACGCCCA	0.448	Pancreas(47;798 1329 9957 10801)		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumensyndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			26	29					0	0	0.001512	0	0
MYO18A	399687	broad.mit.edu	37	17	27493549	27493549	+	Missense_Mutation	SNP	T	T	C			TCGA-50-6673-01A-11D-1945-08	TCGA-50-6673-11A-02D-1945-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc6185f2-f1ea-43ea-8d4f-3b121949d06f	20683d9f-102f-4976-985f-97162ae99514	g.chr17:27493549T>C	uc002hdt.1	-	2	568	c.410A>G	c.(409-411)AAG>AGG	p.K137R	MYO18A_uc010csa.1_Missense_Mutation_p.K137R|MYO18A_uc002hdu.1_Missense_Mutation_p.K137R	NM_078471	NP_510880	Q92614	MY18A_HUMAN	myosin 18A isoform a	137					anti-apoptosis|DNA metabolic process	ER-Golgi intermediate compartment|myosin complex	ATP binding|DNA binding|DNA-dependent ATPase activity|identical protein binding|motor activity				0			Epithelial(11;4.97e-05)|BRCA - Breast invasive adenocarcinoma(11;0.000221)|all cancers(11;0.000234)|Colorectal(6;0.0102)|COAD - Colon adenocarcinoma(6;0.031)			GGAAAAGCGCTTGACAATCAT	0.622	Esophageal Squamous(182;472 2015 7001 15270 22562)		NA											8	64					0	0	0.000274275	0	0
CPD	1362	broad.mit.edu	37	17	28782439	28782439	+	Missense_Mutation	SNP	T	T	G			TCGA-50-6673-01A-11D-1945-08	TCGA-50-6673-11A-02D-1945-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc6185f2-f1ea-43ea-8d4f-3b121949d06f	20683d9f-102f-4976-985f-97162ae99514	g.chr17:28782439T>G	uc002hfb.1	+	15	3303	c.3288T>G	c.(3286-3288)GAT>GAG	p.D1096E	CPD_uc010wbo.1_Missense_Mutation_p.D849E|CPD_uc010wbp.1_Intron	NM_001304	NP_001295	O75976	CBPD_HUMAN	carboxypeptidase D precursor	1096	Extracellular (Potential).|Carboxypeptidase-like 3.				proteolysis	integral to membrane	metallocarboxypeptidase activity|serine-type carboxypeptidase activity|zinc ion binding			liver(1)|skin(1)	2						TTGCCTTAGATGGTGGTTCCA	0.363			NA											16	227					0	0	0.000308642	0	0
CDH7	1005	broad.mit.edu	37	18	63526954	63526954	+	Missense_Mutation	SNP	A	A	G			TCGA-50-6673-01A-11D-1945-08	TCGA-50-6673-11A-02D-1945-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc6185f2-f1ea-43ea-8d4f-3b121949d06f	20683d9f-102f-4976-985f-97162ae99514	g.chr18:63526954A>G	uc002ljz.2	+	10	1830	c.1505A>G	c.(1504-1506)AAA>AGA	p.K502R	CDH7_uc002lka.2_Missense_Mutation_p.K502R|CDH7_uc002lkb.2_Missense_Mutation_p.K502R	NM_033646	NP_387450	Q9ULB5	CADH7_HUMAN	cadherin 7, type 2 preproprotein	502	Extracellular (Potential).|Cadherin 5.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)|pancreas(1)|skin(1)	4		Esophageal squamous(42;0.129)				GTTATCCAGAAAATCAGTGCT	0.363			NA											6	23					0	0	0.00116845	0	0
CYP4F11	57834	broad.mit.edu	37	19	16035624	16035624	+	Missense_Mutation	SNP	C	C	A			TCGA-50-6673-01A-11D-1945-08	TCGA-50-6673-11A-02D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc6185f2-f1ea-43ea-8d4f-3b121949d06f	20683d9f-102f-4976-985f-97162ae99514	g.chr19:16035624C>A	uc002nbu.2	-	6	630	c.594G>T	c.(592-594)ATG>ATT	p.M198I	CYP4F11_uc010eab.1_Missense_Mutation_p.M198I|CYP4F11_uc002nbt.2_Missense_Mutation_p.M198I	NM_001128932	NP_001122404	Q9HBI6	CP4FB_HUMAN	cytochrome P450 family 4 subfamily F polypeptide	198					inflammatory response|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	aromatase activity|electron carrier activity|heme binding			ovary(1)	1						TGTCCAAGGTCATGAGGCTGA	0.537			NA											21	81					9.95505e-16	6.06353e-15	0.000295444	1	0
IL1RL1	9173	broad.mit.edu	37	2	102955462	102955462	+	Missense_Mutation	SNP	C	C	A			TCGA-50-6673-01A-11D-1945-08	TCGA-50-6673-11A-02D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc6185f2-f1ea-43ea-8d4f-3b121949d06f	20683d9f-102f-4976-985f-97162ae99514	g.chr2:102955462C>A	uc002tbu.1	+	3	498	c.227C>A	c.(226-228)CCA>CAA	p.P76Q	IL1RL1_uc010ywa.1_5'UTR|IL18R1_uc002tbw.3_Intron|IL1RL1_uc002tbv.2_Missense_Mutation_p.P76Q	NM_016232	NP_057316	Q01638	ILRL1_HUMAN	interleukin 1 receptor-like 1 isoform 1	76	Extracellular (Potential).|Ig-like C2-type 1.				innate immune response	integral to membrane	interleukin-1 receptor activity|receptor signaling protein activity			skin(2)|ovary(1)|central_nervous_system(1)	4						AAGTTTCTACCAGCTGCAGTT	0.433			NA											19	138					0.000229342	0.00122927	0.00188189	1	0
ZEB2	9839	broad.mit.edu	37	2	145147072	145147072	+	Silent	SNP	C	C	T			TCGA-50-6673-01A-11D-1945-08	TCGA-50-6673-11A-02D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc6185f2-f1ea-43ea-8d4f-3b121949d06f	20683d9f-102f-4976-985f-97162ae99514	g.chr2:145147072C>T	uc002tvu.2	-	10	4071	c.3591G>A	c.(3589-3591)GGG>GGA	p.G1197G	ZEB2_uc002tvv.2_Silent_p.G1191G|ZEB2_uc010zbm.1_Silent_p.G1168G|ZEB2_uc010fnp.2_Intron	NM_014795	NP_055610	O60315	ZEB2_HUMAN	zinc finger homeobox 1b	1197	Glu-rich (acidic).					cytoplasm|nucleolus	phosphatase regulator activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|SMAD binding|zinc ion binding			ovary(5)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)	9				BRCA - Breast invasive adenocarcinoma(221;0.112)		TTTCCATTTTCCCATCCTCCG	0.388	Melanoma(33;1235 1264 5755 16332)		NA											57	236					0	0	0.000781405	0	0
PPIG	9360	broad.mit.edu	37	2	170488419	170488419	+	Missense_Mutation	SNP	G	G	A			TCGA-50-6673-01A-11D-1945-08	TCGA-50-6673-11A-02D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc6185f2-f1ea-43ea-8d4f-3b121949d06f	20683d9f-102f-4976-985f-97162ae99514	g.chr2:170488419G>A	uc002uez.2	+	11	1125	c.905G>A	c.(904-906)AGA>AAA	p.R302K	PPIG_uc010fpx.2_Missense_Mutation_p.R287K|PPIG_uc010fpy.2_Missense_Mutation_p.R295K|PPIG_uc002ufa.2_Missense_Mutation_p.R302K|PPIG_uc002ufb.2_Missense_Mutation_p.R302K|PPIG_uc002ufd.2_Missense_Mutation_p.R299K	NM_004792	NP_004783	Q13427	PPIG_HUMAN	peptidylprolyl isomerase G	302					protein folding|RNA splicing	nuclear matrix|nuclear speck	cyclosporin A binding|peptidyl-prolyl cis-trans isomerase activity			ovary(2)|central_nervous_system(1)	3					L-Proline(DB00172)	aggaaaaacagagagagagaa	0.259			NA											5	19					0	0	0.000602214	0	0
TTN	7273	broad.mit.edu	37	2	179447908	179447908	+	Silent	SNP	A	A	C	rs55766906		TCGA-50-6673-01A-11D-1945-08	TCGA-50-6673-11A-02D-1945-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc6185f2-f1ea-43ea-8d4f-3b121949d06f	20683d9f-102f-4976-985f-97162ae99514	g.chr2:179447908A>C	uc010zfg.1	-	262	58142	c.57918T>G	c.(57916-57918)ACT>ACG	p.T19306T	uc002umo.2_RNA|uc002ump.1_Intron|TTN_uc010zfh.1_Silent_p.T13001T|TTN_uc010zfi.1_Silent_p.T12934T|TTN_uc010zfj.1_Silent_p.T12809T	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	20233							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CAGCTTTCACAGTAAGCAAAG	0.398			NA											6	21					0	0	0.000157383	0	0
VPS16	64601	broad.mit.edu	37	20	2845910	2845910	+	Silent	SNP	T	T	G			TCGA-50-6673-01A-11D-1945-08	TCGA-50-6673-11A-02D-1945-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc6185f2-f1ea-43ea-8d4f-3b121949d06f	20683d9f-102f-4976-985f-97162ae99514	g.chr20:2845910T>G	uc002whe.2	+	21	2169	c.2121T>G	c.(2119-2121)GGT>GGG	p.G707G	VPS16_uc002whh.2_RNA|PTPRA_uc002whj.2_5'UTR|VPS16_uc002whf.2_Silent_p.G563G|VPS16_uc002whd.2_RNA|VPS16_uc002whg.2_Silent_p.G393G|VPS16_uc002whi.2_Silent_p.G191G	NM_022575	NP_072097	Q9H269	VPS16_HUMAN	vacuolar protein sorting 16 isoform 1	707					intracellular protein transport	early endosome|HOPS complex|late endosome membrane|lysosomal membrane|recycling endosome				ovary(2)|pancreas(1)|skin(1)	4						TTCTTGGCGGTCACAACAAGC	0.617			NA											17	43					0	0	0.000958276	0	0
GGT5	2687	broad.mit.edu	37	22	24640618	24640618	+	Missense_Mutation	SNP	C	C	T			TCGA-50-6673-01A-11D-1945-08	TCGA-50-6673-11A-02D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc6185f2-f1ea-43ea-8d4f-3b121949d06f	20683d9f-102f-4976-985f-97162ae99514	g.chr22:24640618C>T	uc002zzo.3	-	1	493	c.76G>A	c.(76-78)GCT>ACT	p.A26T	GGT5_uc002zzp.3_Missense_Mutation_p.A26T|GGT5_uc002zzr.3_Missense_Mutation_p.A26T|GGT5_uc002zzq.3_Missense_Mutation_p.A26T|GGT5_uc011ajm.1_Missense_Mutation_p.A26T|GGT5_uc011ajn.1_RNA	NM_004121	NP_004112	P36269	GGT5_HUMAN	gamma-glutamyltransferase 5 isoform b	26	Helical; Signal-anchor for type II membrane protein; (Potential).				glutathione biosynthetic process|hormone biosynthetic process|leukotriene biosynthetic process|prostanoid metabolic process	integral to membrane|plasma membrane	acyltransferase activity|gamma-glutamyltransferase activity			ovary(2)|skin(1)	3						AGGACCACAGCCAGCACAATG	0.677			NA											15	35					0	0	0.000422831	0	0
CHEK2	11200	broad.mit.edu	37	22	29091782	29091782	+	Missense_Mutation	SNP	G	G	A			TCGA-50-6673-01A-11D-1945-08	TCGA-50-6673-11A-02D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc6185f2-f1ea-43ea-8d4f-3b121949d06f	20683d9f-102f-4976-985f-97162ae99514	g.chr22:29091782G>A	uc003adu.1	-	11	1247	c.1175C>T	c.(1174-1176)GCG>GTG	p.A392V	CHEK2_uc003ads.1_Missense_Mutation_p.A171V|CHEK2_uc010gvh.1_Missense_Mutation_p.A301V|CHEK2_uc010gvi.1_Intron|CHEK2_uc010gvj.1_Intron|CHEK2_uc003adr.1_RNA|CHEK2_uc010gvk.1_RNA|CHEK2_uc003adt.1_Missense_Mutation_p.A435V|CHEK2_uc003adv.1_Missense_Mutation_p.A363V|CHEK2_uc003adw.1_Missense_Mutation_p.A392V|CHEK2_uc003adx.1_Missense_Mutation_p.A171V|CHEK2_uc003ady.1_Missense_Mutation_p.A392V|CHEK2_uc003adz.1_Missense_Mutation_p.A196V	NM_007194	NP_009125	O96017	CHK2_HUMAN	protein kinase CHK2 isoform a	392	Protein kinase.				cell cycle|DNA damage checkpoint|DNA damage response, signal transduction resulting in induction of apoptosis|replicative senescence	PML body	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity	p.A392A(6)		central_nervous_system(17)|stomach(1)|ovary(1)|lung(1)	20						AACTTCAGGCGCCAAGTAGGT	0.428			NA	F			breast 		Direct_reversal_of_damage|Other_conserved_DNA_damage_response_genes	Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|CHEK2-associated_cancer				15	55					0	0	0.000958276	0	0
PHLDB2	90102	broad.mit.edu	37	3	111685542	111685542	+	Nonsense_Mutation	SNP	G	G	T			TCGA-50-6673-01A-11D-1945-08	TCGA-50-6673-11A-02D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc6185f2-f1ea-43ea-8d4f-3b121949d06f	20683d9f-102f-4976-985f-97162ae99514	g.chr3:111685542G>T	uc010hqa.2	+	14	3571	c.3160G>T	c.(3160-3162)GAA>TAA	p.E1054*	PHLDB2_uc003dyc.2_Nonsense_Mutation_p.E1038*|PHLDB2_uc003dyd.2_Nonsense_Mutation_p.E1011*|PHLDB2_uc003dyg.2_Nonsense_Mutation_p.E1054*|PHLDB2_uc003dyh.2_Nonsense_Mutation_p.E1011*|PHLDB2_uc003dyi.2_Nonsense_Mutation_p.E545*|PHLDB2_uc003dyj.2_Nonsense_Mutation_p.E109*	NM_001134438	NP_001127910	Q86SQ0	PHLB2_HUMAN	pleckstrin homology-like domain, family B,	1054	Potential.					cytoplasm|intermediate filament cytoskeleton|plasma membrane				ovary(4)|skin(2)	6						GCGGCTGCTCGAATCCAGGGT	0.348			NA											14	29					1.05317e-09	6.31902e-09	0.000219431	1	0
CCRL1	51554	broad.mit.edu	37	3	132319970	132319970	+	Silent	SNP	C	C	T			TCGA-50-6673-01A-11D-1945-08	TCGA-50-6673-11A-02D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc6185f2-f1ea-43ea-8d4f-3b121949d06f	20683d9f-102f-4976-985f-97162ae99514	g.chr3:132319970C>T	uc003eow.2	+	2	812	c.729C>T	c.(727-729)CTC>CTT	p.L243L	ACAD11_uc003eov.3_Intron|ACAD11_uc011blr.1_Intron|CCRL1_uc003eox.2_Silent_p.L243L	NM_016557	NP_057641	Q9NPB9	CCRL1_HUMAN	chemokine (C-C motif) receptor-like 1	243	Helical; Name=6; (Potential).				chemotaxis|immune response	integral to plasma membrane	C-C chemokine receptor activity				0						AAGTTCTGCTCACAGTCGTTA	0.418	Pancreas(96;1505 1524 4501 17831 18121)		NA											19	50					0	0	0.001512	0	0
TM4SF1	4071	broad.mit.edu	37	3	149093484	149093484	+	Missense_Mutation	SNP	A	A	C			TCGA-50-6673-01A-11D-1945-08	TCGA-50-6673-11A-02D-1945-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc6185f2-f1ea-43ea-8d4f-3b121949d06f	20683d9f-102f-4976-985f-97162ae99514	g.chr3:149093484A>C	uc003exb.1	-	2	484	c.250T>G	c.(250-252)TGT>GGT	p.C84G	TM4SF1_uc003exc.1_5'UTR	NM_014220	NP_055035	P30408	T4S1_HUMAN	transmembrane 4 superfamily member 1	84	Cytoplasmic (Probable).					integral to plasma membrane					0			LUSC - Lung squamous cell carcinoma(72;0.0378)|Lung(72;0.048)			CGTTTGCCACAGTTTTCATGG	0.517			NA											18	157					0	0	0.00152264	0	0
ADIPOQ	9370	broad.mit.edu	37	3	186570990	186570990	+	Missense_Mutation	SNP	G	G	A			TCGA-50-6673-01A-11D-1945-08	TCGA-50-6673-11A-02D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc6185f2-f1ea-43ea-8d4f-3b121949d06f	20683d9f-102f-4976-985f-97162ae99514	g.chr3:186570990G>A	uc003fra.2	+	2	227	c.143G>A	c.(142-144)GGC>GAC	p.G48D	ADIPOQ_uc010hyy.2_Missense_Mutation_p.G48D	NM_004797	NP_004788	Q15848	ADIPO_HUMAN	adiponectin precursor	48	Collagen-like.				brown fat cell differentiation|cellular response to drug|cellular response to insulin stimulus|detection of oxidative stress|fatty acid beta-oxidation|generation of precursor metabolites and energy|glucose homeostasis|glucose metabolic process|low-density lipoprotein particle clearance|negative regulation of blood pressure|negative regulation of DNA biosynthetic process|negative regulation of ERK1 and ERK2 cascade|negative regulation of eukaryotic cell surface binding|negative regulation of fat cell differentiation|negative regulation of gluconeogenesis|negative regulation of granulocyte differentiation|negative regulation of heterotypic cell-cell adhesion|negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of inflammatory response|negative regulation of intracellular protein transport|negative regulation of low-density lipoprotein particle receptor biosynthetic process|negative regulation of macrophage derived foam cell differentiation|negative regulation of macrophage differentiation|negative regulation of MAP kinase activity|negative regulation of phagocytosis|negative regulation of platelet-derived growth factor receptor signaling pathway|negative regulation of protein autophosphorylation|negative regulation of smooth muscle cell migration|negative regulation of smooth muscle cell proliferation|negative regulation of synaptic transmission|negative regulation of transcription, DNA-dependent|negative regulation of tumor necrosis factor production|negative regulation of tumor necrosis factor-mediated signaling pathway|positive regulation of cAMP-dependent protein kinase activity|positive regulation of cholesterol efflux|positive regulation of fatty acid metabolic process|positive regulation of glucose import|positive regulation of glycogen (starch) synthase activity|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-8 production|positive regulation of metanephric glomerular visceral epithelial cell development|positive regulation of monocyte chemotactic protein-1 production|positive regulation of myeloid cell apoptosis|positive regulation of protein kinase A signaling cascade|positive regulation of renal albumin absorption|protein homooligomerization|protein localization in plasma membrane|response to glucose stimulus|response to tumor necrosis factor	collagen|endoplasmic reticulum|extracellular space	cytokine activity|eukaryotic cell surface binding|hormone activity|protein homodimerization activity			ovary(1)	1	all_cancers(143;1.2e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;1.47e-19)	GBM - Glioblastoma multiforme(93;0.0776)		GGGCATCCGGGCCATAATGGG	0.612			NA											8	15					0	0	0.000157383	0	0
MUC4	4585	broad.mit.edu	37	3	195538661	195538662	+	Missense_Mutation	DNP	GG	GG	AC			TCGA-50-6673-01A-11D-1945-08	TCGA-50-6673-11A-02D-1945-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc6185f2-f1ea-43ea-8d4f-3b121949d06f	20683d9f-102f-4976-985f-97162ae99514	g.chr3:195538661_195538662GG>AC	uc011bto.1	-	1	487_488	c.27_28CC>GT	c.(25-30)GTCCCC>GTGTCC	p.P10S	MUC4_uc003fvo.2_Missense_Mutation_p.P10S|MUC4_uc003fvp.2_Missense_Mutation_p.P10S|MUC4_uc010hzv.2_RNA	NM_018406	NP_060876	Q99102	MUC4_HUMAN	mucin 4 isoform a	10					cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity				0	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		GACACCCAGGGGACCCTCCTCC	0.649			NA											13	48					0	0	6.4e-05	0	0
N4BP2	55728	broad.mit.edu	37	4	40122226	40122226	+	Missense_Mutation	SNP	C	C	G			TCGA-50-6673-01A-11D-1945-08	TCGA-50-6673-11A-02D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc6185f2-f1ea-43ea-8d4f-3b121949d06f	20683d9f-102f-4976-985f-97162ae99514	g.chr4:40122226C>G	uc003guy.3	+	9	2833	c.2495C>G	c.(2494-2496)TCT>TGT	p.S832C	N4BP2_uc010ifq.2_Missense_Mutation_p.S752C|N4BP2_uc010ifr.2_Missense_Mutation_p.S752C	NM_018177	NP_060647	Q86UW6	N4BP2_HUMAN	Nedd4 binding protein 2	832						cytoplasm	ATP binding|ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity|endonuclease activity|protein binding			lung(3)|breast(2)|kidney(2)|ovary(1)	8						AACAGTGTATCTGTGAATACA	0.403			NA											4	31					0	0	0.00024832	0	0
FGF10	2255	broad.mit.edu	37	5	44388506	44388506	+	Missense_Mutation	SNP	C	C	G			TCGA-50-6673-01A-11D-1945-08	TCGA-50-6673-11A-02D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc6185f2-f1ea-43ea-8d4f-3b121949d06f	20683d9f-102f-4976-985f-97162ae99514	g.chr5:44388506C>G	uc003jog.1	-	1	279	c.279G>C	c.(277-279)GAG>GAC	p.E93D		NM_004465	NP_004456	O15520	FGF10_HUMAN	fibroblast growth factor 10 precursor	93					actin cytoskeleton reorganization|activation of MAPK activity|bud outgrowth involved in lung branching|ERK1 and ERK2 cascade|fibroblast growth factor receptor signaling pathway involved in mammary gland specification|insulin receptor signaling pathway|lacrimal gland development|lung saccule development|mesonephros development|negative regulation of cell cycle arrest|positive regulation of ATPase activity|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of DNA repair|positive regulation of DNA replication|positive regulation of epithelial cell migration|positive regulation of epithelial cell proliferation involved in wound healing|positive regulation of ERK1 and ERK2 cascade|positive regulation of hair follicle cell proliferation|positive regulation of keratinocyte migration|positive regulation of keratinocyte proliferation|positive regulation of lymphocyte proliferation|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of Ras protein signal transduction|positive regulation of transcription, DNA-dependent|positive regulation of urothelial cell proliferation|protein localization at cell surface|radial glial cell differentiation|regulation of saliva secretion|response to protein stimulus|secretion by lung epithelial cell involved in lung growth|tear secretion|thymus development|urothelial cell proliferation	cell surface|extracellular space|nucleus|plasma membrane	chemoattractant activity|growth factor activity|heparin binding|type 2 fibroblast growth factor receptor binding			lung(3)	3	Lung NSC(6;1.12e-06)					TCCCGTTCTTCTCAATCTTGA	0.517			NA											26	62					0	0	0.000409698	0	0
KIF20A	10112	broad.mit.edu	37	5	137521298	137521298	+	Missense_Mutation	SNP	G	G	A			TCGA-50-6673-01A-11D-1945-08	TCGA-50-6673-11A-02D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc6185f2-f1ea-43ea-8d4f-3b121949d06f	20683d9f-102f-4976-985f-97162ae99514	g.chr5:137521298G>A	uc003lcj.2	+	16	2520	c.2024G>A	c.(2023-2025)CGG>CAG	p.R675Q	KIF20A_uc011cyo.1_Missense_Mutation_p.R657Q	NM_005733	NP_005724	O95235	KI20A_HUMAN	kinesin family member 20A	675	Potential.				cytokinesis|M phase of mitotic cell cycle|microtubule-based movement|protein transport|vesicle-mediated transport	Golgi apparatus|microtubule|nucleoplasm	ATP binding|microtubule motor activity|protein binding|transporter activity				0			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0109)			TTGGCCCTACGGCGGTCACAA	0.507			NA											13	118					0	0	0.000219431	0	0
REEP2	51308	broad.mit.edu	37	5	137776766	137776766	+	Missense_Mutation	SNP	G	G	A	rs147103044		TCGA-50-6673-01A-11D-1945-08	TCGA-50-6673-11A-02D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc6185f2-f1ea-43ea-8d4f-3b121949d06f	20683d9f-102f-4976-985f-97162ae99514	g.chr5:137776766G>A	uc003lcz.2	+	2	216	c.94G>A	c.(94-96)GTG>ATG	p.V32M	REEP2_uc003lda.2_Missense_Mutation_p.V32M|REEP2_uc011cyt.1_Translation_Start_Site	NM_016606	NP_057690	Q9BRK0	REEP2_HUMAN	receptor accessory protein 2	32						integral to membrane					0			KIRC - Kidney renal clear cell carcinoma(527;0.004)|Kidney(363;0.00592)			GACAAAAAACGTGAAGGAATA	0.547			NA											14	34					0	0	0.000308642	0	0
PCDHA10	56139	broad.mit.edu	37	5	140237249	140237249	+	Missense_Mutation	SNP	G	G	C			TCGA-50-6673-01A-11D-1945-08	TCGA-50-6673-11A-02D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc6185f2-f1ea-43ea-8d4f-3b121949d06f	20683d9f-102f-4976-985f-97162ae99514	g.chr5:140237249G>C	uc003lhx.2	+	1	1616	c.1616G>C	c.(1615-1617)GGG>GCG	p.G539A	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc011dad.1_Missense_Mutation_p.G539A	NM_018901	NP_061724	Q9Y5I2	PCDAA_HUMAN	protocadherin alpha 10 isoform 1 precursor	539	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	extracellular region|integral to plasma membrane	calcium ion binding|protein binding			ovary(2)|skin(2)|breast(1)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCGCGCGATGGGGGCGTGCCG	0.687			NA											5	148					0	0	0.000602214	0	0
FCHSD1	89848	broad.mit.edu	37	5	141030648	141030648	+	Nonsense_Mutation	SNP	C	C	A			TCGA-50-6673-01A-11D-1945-08	TCGA-50-6673-11A-02D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc6185f2-f1ea-43ea-8d4f-3b121949d06f	20683d9f-102f-4976-985f-97162ae99514	g.chr5:141030648C>A	uc003llk.2	-	2	109	c.58G>T	c.(58-60)GAA>TAA	p.E20*	FCHSD1_uc003llj.2_RNA	NM_033449	NP_258260	Q86WN1	FCSD1_HUMAN	FCH and double SH3 domains 1	20	FCH.								FCHSD1/BRAF(2)	skin(2)|ovary(1)|central_nervous_system(1)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTCAGCTGTTCCAGGAAGCGA	0.587			NA											5	6					0.00116845	0.00618046	0.00116845	1	0
ADAMTS2	9509	broad.mit.edu	37	5	178541012	178541012	+	Silent	SNP	G	G	A			TCGA-50-6673-01A-11D-1945-08	TCGA-50-6673-11A-02D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc6185f2-f1ea-43ea-8d4f-3b121949d06f	20683d9f-102f-4976-985f-97162ae99514	g.chr5:178541012G>A	uc003mjw.2	-	22	3492	c.3492C>T	c.(3490-3492)CCC>CCT	p.P1164P	uc003mjv.3_5'Flank	NM_014244	NP_055059	O95450	ATS2_HUMAN	ADAM metallopeptidase with thrombospondin type 1	1164					collagen catabolic process	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			large_intestine(1)|lung(1)|ovary(1)|pancreas(1)	4	all_cancers(89;0.000456)|all_epithelial(37;0.000138)|Renal(175;0.000159)|Lung NSC(126;0.00184)|all_lung(126;0.00326)	all_cancers(40;0.00604)|all_neural(177;0.00411)|Medulloblastoma(196;0.00508)|Lung NSC(249;0.0569)|all_lung(500;0.129)|all_hematologic(541;0.211)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	GBM - Glioblastoma multiforme(465;0.0473)		GGATTTTGTAGGGTTCATCTA	0.547			NA											30	103					0	0	0.00178596	0	0
CANX	821	broad.mit.edu	37	5	179151752	179151752	+	Missense_Mutation	SNP	G	G	A			TCGA-50-6673-01A-11D-1945-08	TCGA-50-6673-11A-02D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc6185f2-f1ea-43ea-8d4f-3b121949d06f	20683d9f-102f-4976-985f-97162ae99514	g.chr5:179151752G>A	uc003mkk.2	+	13	1790	c.1613G>A	c.(1612-1614)GGA>GAA	p.G538E	CANX_uc011dgp.1_Missense_Mutation_p.G573E|CANX_uc003mkl.2_Missense_Mutation_p.G538E|CANX_uc011dgq.1_Missense_Mutation_p.G430E	NM_001746	NP_001737	P27824	CALX_HUMAN	calnexin precursor	538	Cytoplasmic (Potential).				post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine|protein secretion	endoplasmic reticulum lumen|endoplasmic reticulum membrane|integral to membrane|melanosome	calcium ion binding|sugar binding|unfolded protein binding				0	all_cancers(89;0.000129)|all_epithelial(37;5.59e-05)|Renal(175;0.000159)|Lung NSC(126;0.00121)|all_lung(126;0.00218)	all_cancers(40;0.0413)|Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)		Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Reteplase(DB00015)|Tenecteplase(DB00031)	aaggacaagggagatgaggag	0.274			NA											7	7					0	0	8.12818e-05	0	0
Unknown	0	broad.mit.edu	37	5	180651713	180651713	+	Missense_Mutation	SNP	C	C	T			TCGA-50-6673-01A-11D-1945-08	TCGA-50-6673-11A-02D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc6185f2-f1ea-43ea-8d4f-3b121949d06f	20683d9f-102f-4976-985f-97162ae99514	g.chr5:180651713C>T	uc003mnb.1	-	2	499	c.179G>A	c.(178-180)CGC>CAC	p.R60H	TRIM41_uc003mnc.1_Silent_p.C238C|TRIM41_uc003mnd.1_Silent_p.C238C|TRIM41_uc003mne.1_Silent_p.C238C|TRIM41_uc003mnf.1_RNA					Homo sapiens cDNA FLJ36305 fis, clone THYMU2004677.												NA						AGCTCTTCTGCGAGGTAGACG	0.592			NA											22	43					0	0	0.00188189	0	0
UTRN	7402	broad.mit.edu	37	6	144875916	144875916	+	Missense_Mutation	SNP	T	T	C			TCGA-50-6673-01A-11D-1945-08	TCGA-50-6673-11A-02D-1945-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc6185f2-f1ea-43ea-8d4f-3b121949d06f	20683d9f-102f-4976-985f-97162ae99514	g.chr6:144875916T>C	uc003qkt.2	+	48	7113	c.7021T>C	c.(7021-7023)TGG>CGG	p.W2341R		NM_007124	NP_009055	P46939	UTRO_HUMAN	utrophin	2341					muscle contraction|muscle organ development|positive regulation of cell-matrix adhesion	cell junction|cytoplasm|cytoskeleton|membrane fraction|nucleus|postsynaptic membrane	actin binding|calcium ion binding|zinc ion binding			ovary(4)|pancreas(1)	5		Ovarian(120;0.218)		OV - Ovarian serous cystadenocarcinoma(155;5.72e-07)|GBM - Glioblastoma multiforme(68;4.9e-05)|Colorectal(48;0.213)		CAGTCTTCAGTGGGATGACCA	0.493			NA											4	67					0	0	0.00024832	0	0
PDE10A	10846	broad.mit.edu	37	6	165848820	165848820	+	Missense_Mutation	SNP	G	G	A			TCGA-50-6673-01A-11D-1945-08	TCGA-50-6673-11A-02D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc6185f2-f1ea-43ea-8d4f-3b121949d06f	20683d9f-102f-4976-985f-97162ae99514	g.chr6:165848820G>A	uc003qun.2	-	7	653	c.412C>T	c.(412-414)CGC>TGC	p.R138C	PDE10A_uc011egj.1_RNA|PDE10A_uc011egk.1_Missense_Mutation_p.R68C|PDE10A_uc003quo.2_Missense_Mutation_p.R148C	NM_006661	NP_006652	Q9Y233	PDE10_HUMAN	phosphodiesterase 10A isoform 2	138	GAF 1.				platelet activation|signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cAMP binding|cGMP binding|metal ion binding			ovary(3)|skin(2)	5		Breast(66;0.000425)|Prostate(117;0.104)|Ovarian(120;0.221)		OV - Ovarian serous cystadenocarcinoma(33;1.5e-17)|BRCA - Breast invasive adenocarcinoma(81;1.8e-06)|GBM - Glioblastoma multiforme(31;1.92e-05)	Dipyridamole(DB00975)	GGGATGAGGCGGGGTTTTCCT	0.488	Esophageal Squamous(22;308 615 5753 12038 40624)		NA											11	55					0	0	0.00185496	0	0
ANKRD7	56311	broad.mit.edu	37	7	117876904	117876904	+	Missense_Mutation	SNP	G	G	C			TCGA-50-6673-01A-11D-1945-08	TCGA-50-6673-11A-02D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc6185f2-f1ea-43ea-8d4f-3b121949d06f	20683d9f-102f-4976-985f-97162ae99514	g.chr7:117876904G>C	uc003vji.2	+	5	809	c.636G>C	c.(634-636)CAG>CAC	p.Q212H		NM_019644	NP_062618	Q92527	ANKR7_HUMAN	ankyrin repeat domain 7	212	ANK 5.				male gonad development						0						TTCTTCTTCAGCAAGGTGTGG	0.393			NA											4	112					0	0	0.00116845	0	0
HSD17B3	3293	broad.mit.edu	37	9	98997839	98997839	+	Missense_Mutation	SNP	C	C	T			TCGA-50-6673-01A-11D-1945-08	TCGA-50-6673-11A-02D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc6185f2-f1ea-43ea-8d4f-3b121949d06f	20683d9f-102f-4976-985f-97162ae99514	g.chr9:98997839C>T	uc004awa.1	-	11	884	c.836G>A	c.(835-837)AGC>AAC	p.S279N	HSD17B3_uc010msc.1_Missense_Mutation_p.S229N	NM_000197	NP_000188	P37058	DHB3_HUMAN	estradiol 17 beta-dehydrogenase 3	279					androgen biosynthetic process|male genitalia development	endoplasmic reticulum membrane|microsome	binding|testosterone 17-beta-dehydrogenase (NAD+) activity|testosterone 17-beta-dehydrogenase (NADP+) activity				0		Acute lymphoblastic leukemia(62;0.0171)|all_hematologic(171;0.214)			NADH(DB00157)	CGGGATCAGGCTCAGAAAGCC	0.488			NA											11	10					0	0	0.000978159	0	0
PTCHD1	139411	broad.mit.edu	37	X	23412156	23412156	+	Missense_Mutation	SNP	A	A	G			TCGA-50-6673-01A-11D-1945-08	TCGA-50-6673-11A-02D-1945-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc6185f2-f1ea-43ea-8d4f-3b121949d06f	20683d9f-102f-4976-985f-97162ae99514	g.chrX:23412156A>G	uc004dal.3	+	3	2529	c.2521A>G	c.(2521-2523)ATT>GTT	p.I841V		NM_173495	NP_775766	Q96NR3	PTHD1_HUMAN	patched domain containing 1	841	Helical; (Potential).				cognition|smoothened signaling pathway	integral to membrane|plasma membrane	hedgehog receptor activity			ovary(4)|kidney(1)|skin(1)	6						CTGCTTTGCCATTTTACCTGT	0.418			NA											35	76					0	0	0.000491102	0	0
WDR13	64743	broad.mit.edu	37	X	48460281	48460281	+	Missense_Mutation	SNP	C	C	A			TCGA-50-6673-01A-11D-1945-08	TCGA-50-6673-11A-02D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc6185f2-f1ea-43ea-8d4f-3b121949d06f	20683d9f-102f-4976-985f-97162ae99514	g.chrX:48460281C>A	uc004dkh.1	+	7	1088	c.941C>A	c.(940-942)GCC>GAC	p.A314D	WDR13_uc010nif.1_Missense_Mutation_p.A192D|WDR13_uc004dki.1_Missense_Mutation_p.A222D|WDR13_uc004dkj.1_Missense_Mutation_p.A314D|WDR13_uc004dkk.1_Missense_Mutation_p.A222D|WDR13_uc004dkl.3_Missense_Mutation_p.A222D	NM_017883	NP_060353	Q9H1Z4	WDR13_HUMAN	WD repeat domain 13 protein	314	WD 3.					cytoplasm|nucleus				ovary(2)	2						TCCTTTGATGCCCCTGGCCGG	0.577			NA											11	37					5.50884e-06	3.11909e-05	0.00136819	1	0
CCNB3	85417	broad.mit.edu	37	X	50094701	50094701	+	Nonstop_Mutation	SNP	A	A	G			TCGA-50-6673-01A-11D-1945-08	TCGA-50-6673-11A-02D-1945-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc6185f2-f1ea-43ea-8d4f-3b121949d06f	20683d9f-102f-4976-985f-97162ae99514	g.chrX:50094701A>G	uc004dox.3	+	13	4485	c.4187A>G	c.(4186-4188)TAG>TGG	p.*1396W	CCNB3_uc004doy.2_Nonstop_Mutation_p.*1396W|CCNB3_uc004doz.2_Nonstop_Mutation_p.*292W|CCNB3_uc010njq.2_Nonstop_Mutation_p.*288W|CCNB3_uc004dpa.2_Nonstop_Mutation_p.*235W	NM_033031	NP_149020	Q8WWL7	CCNB3_HUMAN	cyclin B3 isoform 3	1396					cell division|meiosis|regulation of cyclin-dependent protein kinase activity|regulation of G2/M transition of mitotic cell cycle	nucleus	protein kinase binding			ovary(4)|lung(3)|large_intestine(1)|pancreas(1)	9	Ovarian(276;0.236)					CTGGTACTCTAGCAGCAGCCA	0.428			NA											5	48					0	0	0.000602214	0	0
FAM155B	27112	broad.mit.edu	37	X	68725635	68725635	+	Missense_Mutation	SNP	C	C	A			TCGA-50-6673-01A-11D-1945-08	TCGA-50-6673-11A-02D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc6185f2-f1ea-43ea-8d4f-3b121949d06f	20683d9f-102f-4976-985f-97162ae99514	g.chrX:68725635C>A	uc004dxk.2	+	1	558	c.510C>A	c.(508-510)GAC>GAA	p.D170E		NM_015686	NP_056501	O75949	F155B_HUMAN	transmembrane protein 28	170						integral to membrane				ovary(1)|breast(1)	2						GGCCCCCTGACTCCCTTTCCC	0.592			NA											11	34					6.40141e-05	0.000352516	0.000978159	1	0
PPAPDC1A	196051	broad.mit.edu	37	10	122280537	122280539	+	In_Frame_Del	DEL	AAT	AAT	-			TCGA-50-6673-01A-11D-1945-08	TCGA-50-6673-11A-02D-1945-08	AAT	AAT	-	-	AAT	AAT	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc6185f2-f1ea-43ea-8d4f-3b121949d06f	20683d9f-102f-4976-985f-97162ae99514	g.chr10:122280537_122280539delAAT	uc001lev.1	+	5	727_729	c.375_377delAAT	c.(373-378)GAAATG>GAG	p.M126del	PPAPDC1A_uc010qtd.1_In_Frame_Del_p.M126del|PPAPDC1A_uc009xzl.1_Intron|PPAPDC1A_uc001lew.1_Intron|PPAPDC1A_uc001lex.1_Intron|PPAPDC1A_uc001ley.1_In_Frame_Del_p.M5del	NM_001030059	NP_001025230	Q5VZY2	PPC1A_HUMAN	phosphatidic acid phosphatase type 2 domain	126					phospholipid dephosphorylation	integral to membrane	phosphatidate phosphatase activity			breast(1)	1		Lung NSC(174;0.1)|all_lung(145;0.132)		all cancers(201;0.0117)		TGAACTCGGAAATGCATTGCACA	0.493			NA											20	42	---	---	---	---	NA	NA	NA	NA	NA
CHD4	1108	broad.mit.edu	37	12	6711145	6711147	+	In_Frame_Del	DEL	TCC	TCC	-	rs1639122	byFrequency	TCGA-50-6673-01A-11D-1945-08	TCGA-50-6673-11A-02D-1945-08	TCC	TCC	-	-	TCC	TCC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc6185f2-f1ea-43ea-8d4f-3b121949d06f	20683d9f-102f-4976-985f-97162ae99514	g.chr12:6711145_6711147delTCC	uc001qpo.2	-	4	581_583	c.417_419delGGA	c.(415-420)GAGGAT>GAT	p.E139del	CHD4_uc001qpn.2_In_Frame_Del_p.E132del|CHD4_uc001qpp.2_In_Frame_Del_p.E136del	NM_001273	NP_001264	Q14839	CHD4_HUMAN	chromodomain helicase DNA binding protein 4	139	Poly-Asp.				chromatin modification|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	microtubule organizing center|NuRD complex	ATP binding|ATP-dependent DNA helicase activity|DNA binding|zinc ion binding			central_nervous_system(2)	2						ATCATCATCAtcctcctcctcct	0.384	Colon(32;586 792 4568 16848 45314)		NA											7	45	---	---	---	---	NA	NA	NA	NA	NA
ABCC4	10257	broad.mit.edu	37	13	95818595	95818595	+	Frame_Shift_Del	DEL	G	G	-			TCGA-50-6673-01A-11D-1945-08	TCGA-50-6673-11A-02D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc6185f2-f1ea-43ea-8d4f-3b121949d06f	20683d9f-102f-4976-985f-97162ae99514	g.chr13:95818595delG	uc001vmd.3	-	15	1970	c.1851delC	c.(1849-1851)TACfs	p.Y617fs	ABCC4_uc010afk.2_Frame_Shift_Del_p.Y617fs|ABCC4_uc001vme.2_Frame_Shift_Del_p.Y617fs|ABCC4_uc010tih.1_Frame_Shift_Del_p.Y542fs|ABCC4_uc001vmf.2_Frame_Shift_Del_p.Y574fs|ABCC4_uc010afl.1_Frame_Shift_Del_p.Y574fs|ABCC4_uc010afm.1_Frame_Shift_Del_p.Y630fs	NM_005845	NP_005836	O15439	MRP4_HUMAN	ATP-binding cassette, sub-family C, member 4	617	ABC transporter 1.				platelet activation|platelet degranulation	integral to membrane|membrane fraction|plasma membrane|platelet dense granule membrane	15-hydroxyprostaglandin dehydrogenase (NAD+) activity|ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|chloride channel activity			central_nervous_system(3)|skin(1)	4	all_neural(89;0.0878)|Medulloblastoma(90;0.163)				Cefazolin(DB01327)	GGAACTCAGTGTAAGTCCCCT	0.368			NA											9	57	---	---	---	---	NA	NA	NA	NA	NA
SLC7A5	8140	broad.mit.edu	37	16	87870213	87870213	+	Frame_Shift_Del	DEL	A	A	-			TCGA-50-6673-01A-11D-1945-08	TCGA-50-6673-11A-02D-1945-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc6185f2-f1ea-43ea-8d4f-3b121949d06f	20683d9f-102f-4976-985f-97162ae99514	g.chr16:87870213delA	uc002fkm.2	-	8	1253	c.1181delT	c.(1180-1182)TTCfs	p.F394fs		NM_003486	NP_003477	Q01650	LAT1_HUMAN	solute carrier family 7 (cationic amino acid	394					blood coagulation|cell differentiation|cellular amino acid metabolic process|ion transport|leukocyte migration|nervous system development	apical plasma membrane|cytosol|integral to membrane	neutral amino acid transmembrane transporter activity|peptide antigen binding				0				BRCA - Breast invasive adenocarcinoma(80;0.049)		GATGACGGAGAAGATGTCCTT	0.612			NA											12	34	---	---	---	---	NA	NA	NA	NA	NA
SERTAD1	29950	broad.mit.edu	37	19	40929409	40929411	+	In_Frame_Del	DEL	CTC	CTC	-			TCGA-50-6673-01A-11D-1945-08	TCGA-50-6673-11A-02D-1945-08	CTC	CTC	-	-	CTC	CTC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc6185f2-f1ea-43ea-8d4f-3b121949d06f	20683d9f-102f-4976-985f-97162ae99514	g.chr19:40929409_40929411delCTC	uc002ont.3	-	2	202_204	c.43_45delGAG	c.(43-45)GAGdel	p.E15del		NM_013376	NP_037508	Q9UHV2	SRTD1_HUMAN	SERTA domain containing 1	15					positive regulation of cell proliferation|regulation of cyclin-dependent protein kinase activity|regulation of transcription, DNA-dependent|transcription, DNA-dependent						0			Lung(22;6.24e-05)|LUSC - Lung squamous cell carcinoma(20;0.000384)			GAGGTTCCTTCTCCTCCTCCTCC	0.453			NA											7	78	---	---	---	---	NA	NA	NA	NA	NA
TTC3	7267	broad.mit.edu	37	21	38555171	38555180	+	Frame_Shift_Del	DEL	ATCACTGAAG	ATCACTGAAG	-			TCGA-50-6673-01A-11D-1945-08	TCGA-50-6673-11A-02D-1945-08	ATCACTGAAG	ATCACTGAAG	-	-	ATCACTGAAG	ATCACTGAAG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc6185f2-f1ea-43ea-8d4f-3b121949d06f	20683d9f-102f-4976-985f-97162ae99514	g.chr21:38555171_38555180delATCACTGAAG	uc002yvz.2	+	36	4818_4827	c.4713_4722delATCACTGAAG	c.(4711-4722)AAATCACTGAAGfs	p.K1571fs	TTC3_uc002ywa.2_Frame_Shift_Del_p.K1571fs|TTC3_uc002ywb.2_Frame_Shift_Del_p.K1571fs|TTC3_uc010gnf.2_Frame_Shift_Del_p.K1336fs|TTC3_uc002ywc.2_Frame_Shift_Del_p.K1261fs|TTC3_uc002ywd.1_Frame_Shift_Del_p.K635fs	NM_001001894	NP_001001894	P53804	TTC3_HUMAN	tetratricopeptide repeat domain 3	1571_1574	Arg/Lys-rich (basic).				protein K48-linked ubiquitination|ubiquitin-dependent protein catabolic process	nucleus	protein binding|ubiquitin-protein ligase activity|zinc ion binding			skin(3)|ovary(2)|lung(2)|breast(2)	9		Myeloproliferative disorder(46;0.0412)				AAAGACTAAAATCACTGAAGAAGAAAATTA	0.271	Ovarian(38;194 1649 35661)		NA											9	34	---	---	---	---	NA	NA	NA	NA	NA
PCDHA5	56143	broad.mit.edu	37	5	140202657	140202658	+	Frame_Shift_Ins	INS	-	-	A			TCGA-50-6673-01A-11D-1945-08	TCGA-50-6673-11A-02D-1945-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc6185f2-f1ea-43ea-8d4f-3b121949d06f	20683d9f-102f-4976-985f-97162ae99514	g.chr5:140202657_140202658insA	uc003lhl.2	+	1	1297_1298	c.1297_1298insA	c.(1297-1299)TCGfs	p.S433fs	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Frame_Shift_Ins_p.S433fs|PCDHA5_uc003lhj.1_Frame_Shift_Ins_p.S433fs	NM_018908	NP_061731	Q9Y5H7	PCDA5_HUMAN	protocadherin alpha 5 isoform 1 precursor	433	Extracellular (Potential).|Cadherin 4.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(1)|breast(1)|skin(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGGCTCGCCTTCGCTGTGGGCC	0.639			NA											44	141	---	---	---	---	NA	NA	NA	NA	NA
FAM184A	79632	broad.mit.edu	37	6	119324685	119324686	+	Frame_Shift_Ins	INS	-	-	A			TCGA-50-6673-01A-11D-1945-08	TCGA-50-6673-11A-02D-1945-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc6185f2-f1ea-43ea-8d4f-3b121949d06f	20683d9f-102f-4976-985f-97162ae99514	g.chr6:119324685_119324686insA	uc003pyj.2	-	8	2265_2266	c.1917_1918insT	c.(1915-1920)ATTAAGfs	p.I639fs	FAM184A_uc003pyk.3_Frame_Shift_Ins_p.I519fs|FAM184A_uc003pyl.3_Frame_Shift_Ins_p.I519fs	NM_024581	NP_078857	Q8NB25	F184A_HUMAN	hypothetical protein LOC79632 isoform 1	639_640	Potential.									ovary(2)|central_nervous_system(2)|skin(2)|pancreas(1)	7						TCAGTCCACTTAATTTCTAAGT	0.347			NA											24	50	---	---	---	---	NA	NA	NA	NA	NA
EGFR	1956	broad.mit.edu	37	7	55249017	55249018	+	In_Frame_Ins	INS	-	-	CCA			TCGA-50-6673-01A-11D-1945-08	TCGA-50-6673-11A-02D-1945-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	fc6185f2-f1ea-43ea-8d4f-3b121949d06f	20683d9f-102f-4976-985f-97162ae99514	g.chr7:55249017_55249018insCCA	uc003tqk.2	+	20	2561_2562	c.2315_2316insCCA	c.(2314-2316)CCC>CCCCAC	p.773_774insH	EGFR_uc010kzg.1_In_Frame_Ins_p.728_729insH|EGFR_uc011kco.1_In_Frame_Ins_p.720_721insH|uc003tqo.2_RNA	NM_005228	NP_005219	P00533	EGFR_HUMAN	epidermal growth factor receptor isoform a	773_774	Cytoplasmic (Potential).|Protein kinase.				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.H773_V774insNPH(12)|p.P772_H773insPR(11)|p.H773R(9)|p.H773_V774insPH(3)|p.H773_V774insH(3)|p.P772_H773insYNP(2)|p.H773Y(2)|p.P772_H773insX(2)|p.N771_P772>SVDNR(1)|p.P772_H773insTHP(1)|p.H773_V774insGH(1)|p.H773L(1)|p.H773_V774insG(1)|p.P772_H773insQV(1)|p.H773_V774insGNPH(1)|p.H773>NPY(1)|p.H773_V774>LM(1)|p.P772_H773insDHP(1)|p.P772P(1)|p.P772_H773insDNP(1)|p.D770_P772>ASVDNR(1)		lung(9213)|central_nervous_system(103)|stomach(41)|upper_aerodigestive_tract(39)|prostate(32)|ovary(31)|thyroid(24)|breast(11)|peritoneum(9)|oesophagus(9)|salivary_gland(9)|large_intestine(8)|kidney(8)|urinary_tract(6)|skin(5)|adrenal_gland(5)|soft_tissue(4)|bone(3)|NS(2)|pancreas(2)|haematopoietic_and_lymphoid_tissue(2)|thymus(2)|liver(2)|eye(1)	9571	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	GTGGACAACCCCCACGTGTGCC	0.644			8	A|O|Mis		glioma|NSCLC	NSCLC			Lung_Cancer_Familial_Clustering_of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			129	172	---	---	---	---	NA	NA	NA	NA	NA