Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	ACHILLES_Top_Genes	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
KIF1B	23095	broad.mit.edu	37	1	10421840	10421840	+	Missense_Mutation	SNP	C	C	G			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr1:10421840C>G	uc001aqx.3	+	40	4463	c.4261C>G	c.(4261-4263)CTG>GTG	p.L1421V	KIF1B_uc001aqw.3_Missense_Mutation_p.L1375V|KIF1B_uc001aqy.2_Missense_Mutation_p.L1395V|KIF1B_uc001aqz.2_Missense_Mutation_p.L1421V|KIF1B_uc001ara.2_Missense_Mutation_p.L1381V|KIF1B_uc001arb.2_Missense_Mutation_p.L1407V	NM_015074	NP_055889	O60333	KIF1B_HUMAN	kinesin family member 1B isoform b	1421					anterograde axon cargo transport|apoptosis|neuromuscular synaptic transmission|neuron-neuron synaptic transmission	cytoplasmic vesicle membrane|microtubule|microtubule associated complex|mitochondrion	ATP binding|ATPase activity|kinesin binding|microtubule motor activity|protein binding			ovary(2)|upper_aerodigestive_tract(1)	3	Ovarian(185;0.203)	all_lung(284;1.31e-05)|Lung NSC(185;2.2e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0259)|Colorectal(212;9.79e-07)|COAD - Colon adenocarcinoma(227;0.000143)|BRCA - Breast invasive adenocarcinoma(304;0.000413)|Kidney(185;0.00134)|KIRC - Kidney renal clear cell carcinoma(229;0.0037)|STAD - Stomach adenocarcinoma(132;0.0113)|READ - Rectum adenocarcinoma(331;0.0642)		ACCACGCTCTCTGCGTAGCCT	0.488			NA											7	110					0	0	0.001984	0	0
PRAMEF4	400735	broad.mit.edu	37	1	12939843	12939843	+	Missense_Mutation	SNP	G	G	T			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr1:12939843G>T	uc001aun.2	-	4	1030	c.959C>A	c.(958-960)CCG>CAG	p.P320Q		NM_001009611	NP_001009611	O60810	PRAM4_HUMAN	PRAME family member 4	320										ovary(1)	1	Ovarian(185;0.249)	Lung NSC(185;3.67e-05)|all_lung(284;4.03e-05)|Renal(390;0.000147)|Breast(348;0.000278)|Colorectal(325;0.00058)|Ovarian(437;0.00965)|Hepatocellular(190;0.0245)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;4.88e-06)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|COAD - Colon adenocarcinoma(227;0.000241)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		ACTGATACTCGGGCACTGGGA	0.468			NA											30	383					1.69901e-12	2.69367e-12	0.005524	1	0
CELA2A	63036	broad.mit.edu	37	1	15792622	15792622	+	Missense_Mutation	SNP	G	G	A			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr1:15792622G>A	uc001awk.2	+	6	648	c.622G>A	c.(622-624)GTG>ATG	p.V208M		NM_033440	NP_254275	P08217	CEL2A_HUMAN	elastase 2A preproprotein	208	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			ovary(2)	2						GGGTGATGGCGTGATCTCCAG	0.577			NA											4	143					0	0	0.000602	0	0
PADI4	23569	broad.mit.edu	37	1	17664568	17664568	+	Silent	SNP	C	C	T			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr1:17664568C>T	uc001baj.2	+	5	472	c.444C>T	c.(442-444)GCC>GCT	p.A148A	PADI4_uc009vpc.2_Silent_p.A148A	NM_012387	NP_036519	Q9UM07	PADI4_HUMAN	peptidyl arginine deiminase, type IV	148					chromatin modification|peptidyl-citrulline biosynthetic process from peptidyl-arginine|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	calcium ion binding|protein-arginine deiminase activity			ovary(1)|skin(1)	2		Colorectal(325;3.46e-05)|Breast(348;0.000162)|all_lung(284;0.000338)|Lung NSC(340;0.00042)|Renal(390;0.000518)|Ovarian(437;0.00409)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00537)|BRCA - Breast invasive adenocarcinoma(304;8.54e-06)|COAD - Colon adenocarcinoma(227;1.33e-05)|Kidney(64;0.000223)|KIRC - Kidney renal clear cell carcinoma(64;0.00313)|STAD - Stomach adenocarcinoma(196;0.00707)|READ - Rectum adenocarcinoma(331;0.0689)|Lung(427;0.199)	L-Citrulline(DB00155)	GACAGGGTGCCATCCTGCTGG	0.532			NA											5	69					0	0	0.000602	0	0
AKR7A2	8574	broad.mit.edu	37	1	19634651	19634651	+	Splice_Site	SNP	C	C	A			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr1:19634651C>A	uc001bbw.2	-	3	613	c.591_splice	c.e3+1	p.Q197_splice	AKR7A2_uc001bbx.2_Intron|AKR7A2_uc009vpi.1_Missense_Mutation_p.V198L	NM_003689	NP_003680	O43488	ARK72_HUMAN	aldo-keto reductase family 7, member A2						carbohydrate metabolic process|cellular aldehyde metabolic process	Golgi apparatus	alditol:NADP+ 1-oxidoreductase activity|electron carrier activity			central_nervous_system(1)	1		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000321)|Lung NSC(340;0.000398)|Breast(348;0.00049)|Ovarian(437;0.00764)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00461)|BRCA - Breast invasive adenocarcinoma(304;1.83e-05)|Kidney(64;0.000167)|GBM - Glioblastoma multiforme(114;0.00115)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)		CCGGCCCTCACCTGGTACACA	0.617			NA											9	59					1.76689e-08	2.52541e-08	0.006214	1	0
KDM1A	23028	broad.mit.edu	37	1	23382500	23382500	+	Missense_Mutation	SNP	T	T	G			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr1:23382500T>G	uc001bgi.2	+	6	1048	c.899T>G	c.(898-900)TTT>TGT	p.F300C	KDM1A_uc001bgj.2_Missense_Mutation_p.F320C	NM_015013	NP_055828	O60341	KDM1A_HUMAN	lysine-specific histone demethylase 1 isoform b	300	FAD (Potential).|Demethylase activity.				blood coagulation|muscle cell development|negative regulation of apoptosis|negative regulation of DNA damage response, signal transduction by p53 class mediator|negative regulation of protein binding|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nuclear chromatin	androgen receptor binding|chromatin binding|enzyme binding|flavin adenine dinucleotide binding|histone demethylase activity (H3-dimethyl-K4 specific)|histone demethylase activity (H3-K9 specific)|ligand-dependent nuclear receptor transcription coactivator activity|MyoD binding|oxidoreductase activity|p53 binding|transcription regulatory region DNA binding			ovary(1)|lung(1)	2						TTACAAAGTTTTGGAATGGAT	0.373			NA											5	94					0	0	0.001168	0	0
ZNF436	80818	broad.mit.edu	37	1	23689281	23689281	+	Missense_Mutation	SNP	C	C	G			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr1:23689281C>G	uc001bgt.2	-	3	975	c.594G>C	c.(592-594)GAG>GAC	p.E198D	ZNF436_uc001bgu.2_Missense_Mutation_p.E198D	NM_030634	NP_085137	Q9C0F3	ZN436_HUMAN	zinc finger protein 436	198	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)	1		Colorectal(325;3.46e-05)|Lung NSC(340;4.15e-05)|all_lung(284;6.64e-05)|Renal(390;0.000219)|Breast(348;0.00262)|Ovarian(437;0.00539)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;6.44e-26)|Colorectal(126;5.5e-08)|COAD - Colon adenocarcinoma(152;3.09e-06)|GBM - Glioblastoma multiforme(114;5.97e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000977)|KIRC - Kidney renal clear cell carcinoma(1967;0.00336)|STAD - Stomach adenocarcinoma(196;0.0127)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.0853)|LUSC - Lung squamous cell carcinoma(448;0.187)		TTTTCCCACACTCGTTACAGT	0.423			NA											8	200					0	0	0.00308	0	0
EXTL1	2134	broad.mit.edu	37	1	26349661	26349661	+	Missense_Mutation	SNP	T	T	A			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr1:26349661T>A	uc001blf.2	+	1	1391	c.524T>A	c.(523-525)CTG>CAG	p.L175Q		NM_004455	NP_004446	Q92935	EXTL1_HUMAN	exostoses-like 1	175	Lumenal (Potential).				skeletal system development	integral to membrane|intrinsic to endoplasmic reticulum membrane	glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity|protein binding			central_nervous_system(1)	1		Colorectal(325;3.46e-05)|Lung NSC(340;6.18e-05)|all_lung(284;9.43e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0155)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0298)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;6.44e-26)|Colorectal(126;2.96e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.000716)|BRCA - Breast invasive adenocarcinoma(304;0.000954)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.00594)|READ - Rectum adenocarcinoma(331;0.0649)		ACCTTCCAGCTGGGACAGGCT	0.642			NA											4	29					0	0	0.000248	0	0
COL16A1	1307	broad.mit.edu	37	1	32138038	32138038	+	Silent	SNP	C	C	T			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr1:32138038C>T	uc001btk.1	-	47	3449	c.3084G>A	c.(3082-3084)TTG>TTA	p.L1028L	COL16A1_uc001bti.1_5'Flank|COL16A1_uc001btj.1_Silent_p.L841L	NM_001856	NP_001847	Q07092	COGA1_HUMAN	alpha 1 type XVI collagen precursor	1028	Triple-helical region 2 (COL2) with 2 imperfections.				cell adhesion|female pregnancy|integrin-mediated signaling pathway	collagen type XVI	integrin binding|structural molecule activity			ovary(8)	8		Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0423)|all_neural(195;0.0837)|Breast(348;0.116)		STAD - Stomach adenocarcinoma(196;0.059)		TCTGGCCTGGCAATCCCGGAG	0.557	Colon(143;498 1786 21362 25193 36625)		NA											8	56					0	0	0.006214	0	0
COL16A1	1307	broad.mit.edu	37	1	32155342	32155342	+	Missense_Mutation	SNP	C	C	A			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr1:32155342C>A	uc001btk.1	-	23	1985	c.1620G>T	c.(1618-1620)AGG>AGT	p.R540S	COL16A1_uc001btj.1_Missense_Mutation_p.R369S|COL16A1_uc001btl.3_Missense_Mutation_p.R540S	NM_001856	NP_001847	Q07092	COGA1_HUMAN	alpha 1 type XVI collagen precursor	540	Cell attachment site (Potential).|Triple-helical region 8 (COL8) with 1 imperfection.				cell adhesion|female pregnancy|integrin-mediated signaling pathway	collagen type XVI	integrin binding|structural molecule activity			ovary(8)	8		Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0423)|all_neural(195;0.0837)|Breast(348;0.116)		STAD - Stomach adenocarcinoma(196;0.059)		GGGCACTCACCCTGGCTGGTA	0.567	Colon(143;498 1786 21362 25193 36625)		NA											8	47					3.86212e-05	4.81489e-05	0.008291	1	0
LCK	3932	broad.mit.edu	37	1	32745303	32745303	+	Silent	SNP	A	A	C			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr1:32745303A>C	uc001bux.2	+	10	1134	c.996A>C	c.(994-996)TCA>TCC	p.S332S	LCK_uc001buy.2_Silent_p.S332S|LCK_uc001buz.2_Silent_p.S362S|LCK_uc010ohc.1_Silent_p.S376S|LCK_uc001bva.2_Silent_p.S339S	NM_005356	NP_005347	P06239	LCK_HUMAN	lymphocyte-specific protein tyrosine kinase	332	Protein kinase.				activation of caspase activity|cellular zinc ion homeostasis|induction of apoptosis|interspecies interaction between organisms|leukocyte migration|platelet activation|positive regulation of T cell receptor signaling pathway|regulation of defense response to virus by virus|release of sequestered calcium ion into cytosol|response to drug|T cell costimulation|T cell differentiation|T cell receptor signaling pathway|viral reproduction	cytosol|Golgi apparatus|membrane raft|pericentriolar material|plasma membrane	ATP binding|ATPase binding|CD4 receptor binding|CD8 receptor binding|glycoprotein binding|non-membrane spanning protein tyrosine kinase activity|phosphatidylinositol 3-kinase binding|protein C-terminus binding|protein kinase binding|protein serine/threonine phosphatase activity|SH2 domain binding			lung(3)|central_nervous_system(2)|ovary(1)	6		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Ovarian(437;0.101)|Breast(348;0.212)			Dasatinib(DB01254)	AGACCCCTTCAGGCATCAAGT	0.577			NA	T	TRB@	T-ALL								21	219					0	0	0.002299	0	0
INPP5B	3633	broad.mit.edu	37	1	38341286	38341286	+	Nonsense_Mutation	SNP	T	T	A			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr1:38341286T>A	uc001ccg.1	-	17	1874	c.1780A>T	c.(1780-1782)AAG>TAG	p.K594*	INPP5B_uc009vvk.1_Nonsense_Mutation_p.K535*|INPP5B_uc001ccf.1_Nonsense_Mutation_p.K430*|INPP5B_uc010oij.1_RNA	NM_005540	NP_005531	P32019	I5P2_HUMAN	inositol polyphosphate-5-phosphatase, 75kDa	674					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|integral to membrane|microtubule cytoskeleton	GTPase activator activity|inositol-polyphosphate 5-phosphatase activity|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|protein binding			urinary_tract(1)	1	Acute lymphoblastic leukemia(166;0.074)|all_hematologic(146;0.197)	Myeloproliferative disorder(586;0.0255)				ACCTCTCGCTTGGACAGGGAC	0.343			NA											4	52					0	0	0.000248	0	0
MACF1	23499	broad.mit.edu	37	1	39844975	39844975	+	Silent	SNP	C	C	A			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr1:39844975C>A	uc010oiu.1	+	18	8828	c.8697C>A	c.(8695-8697)CTC>CTA	p.L2899L	MACF1_uc010ois.1_Silent_p.L2397L|MACF1_uc001cda.1_Silent_p.L2284L|MACF1_uc001cdc.1_Silent_p.L1463L	NM_033044	NP_149033	Q9UPN3	MACF1_HUMAN	microfilament and actin filament cross-linker	4464					cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			ovary(8)|breast(3)|central_nervous_system(3)|skin(2)	16	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			AGGCTATCCTCAACAGAATGG	0.473			NA											18	222					3.52763e-06	4.65417e-06	0.00499	1	0
DMBX1	127343	broad.mit.edu	37	1	46976740	46976740	+	Missense_Mutation	SNP	A	A	C			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr1:46976740A>C	uc001cpx.2	+	3	497	c.482A>C	c.(481-483)CAG>CCG	p.Q161P	DMBX1_uc001cpw.2_Missense_Mutation_p.Q156P	NM_147192	NP_671725	Q8NFW5	DMBX1_HUMAN	diencephalon/mesencephalon homeobox 1 isoform b	161					brain development|developmental growth|negative regulation of transcription, DNA-dependent	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1	Acute lymphoblastic leukemia(166;0.155)					CCAGATACCCAGCTGGACACT	0.637			NA											5	52					0	0	0.000602	0	0
DMRTA2	63950	broad.mit.edu	37	1	50885323	50885323	+	Missense_Mutation	SNP	T	T	G			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr1:50885323T>G	uc010ona.1	-	2	739	c.643A>C	c.(643-645)AAG>CAG	p.K215Q	DMRTA2_uc010onb.1_Missense_Mutation_p.K215Q	NM_032110	NP_115486	Q96SC8	DMTA2_HUMAN	DMRT-like family A2	215	Gly-rich.				sex differentiation	nucleus	DNA binding|metal ion binding|sequence-specific DNA binding transcription factor activity				0						GATAAGGGCTTCACCGGCGGC	0.677	Colon(196;1651 2045 3292 36497 38236)|Esophageal Squamous(2;257 258 11567 27043 43804)		NA											2	6					0	0	0.004672	0	0
PDE4B	5142	broad.mit.edu	37	1	66384348	66384348	+	Silent	SNP	C	C	T			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr1:66384348C>T	uc001dcn.2	+	3	302	c.111C>T	c.(109-111)ATC>ATT	p.I37I	PDE4B_uc009war.2_Intron|PDE4B_uc001dco.2_Silent_p.I37I	NM_001037341	NP_001032418	Q07343	PDE4B_HUMAN	phosphodiesterase 4B isoform 1	37					signal transduction	cytosol|insoluble fraction|soluble fraction	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding			ovary(2)|central_nervous_system(1)	3					Adenosine monophosphate(DB00131)|Amrinone(DB01427)|Caffeine(DB00201)|Cilostazol(DB01166)|Dyphylline(DB00651)|Enprofylline(DB00824)|Papaverine(DB01113)|Pentoxifylline(DB00806)|Theophylline(DB00277)	CACTTGGGATCGACCTCTGGA	0.438			NA											6	104					0	0	0.001168	0	0
C1orf173	127254	broad.mit.edu	37	1	75086563	75086563	+	Silent	SNP	A	A	G			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr1:75086563A>G	uc001dgg.2	-	8	1074	c.855T>C	c.(853-855)AGT>AGC	p.S285S	uc001dgh.2_Intron|C1orf173_uc001dgi.3_Silent_p.S79S	NM_001002912	NP_001002912	Q5RHP9	CA173_HUMAN	hypothetical protein LOC127254	285										ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	5						TAGCTGCATTACTATGTAAGG	0.343			NA											5	59					0	0	0.000602	0	0
EPHX4	253152	broad.mit.edu	37	1	92511124	92511125	+	Missense_Mutation	DNP	GG	GG	TT			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr1:92511124_92511125GG>TT	uc001don.2	+	4	615_616	c.511_512GG>TT	c.(511-513)GGG>TTG	p.G171L		NM_173567	NP_775838	Q8IUS5	EPHX4_HUMAN	abhydrolase domain containing 7	171						integral to membrane	hydrolase activity			central_nervous_system(1)	1						CCATGACTGGGGGGGCATGATT	0.391	GBM(140;473 1857 5172 22066 49719)		NA											21	126					0	0	0.004672	0	0
CDC14A	8556	broad.mit.edu	37	1	100950007	100950007	+	Missense_Mutation	SNP	G	G	T			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr1:100950007G>T	uc001dtg.3	+	11	1625	c.1137G>T	c.(1135-1137)GAG>GAT	p.E379D	CDC14A_uc009web.2_RNA|CDC14A_uc010oui.1_Missense_Mutation_p.E321D|CDC14A_uc001dte.3_Missense_Mutation_p.E379D|CDC14A_uc001dtf.2_Missense_Mutation_p.E379D|CDC14A_uc009wed.1_Missense_Mutation_p.E86D|CDC14A_uc009wee.2_Missense_Mutation_p.E379D	NM_003672	NP_003663	Q9UNH5	CC14A_HUMAN	CDC14 homolog A isoform 1	379					cell cycle|cell division|cell proliferation	centrosome|nucleus|spindle	protein binding|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			large_intestine(1)	1		all_epithelial(167;3.71e-06)|all_lung(203;0.00097)|Lung NSC(277;0.001)		Epithelial(280;0.0676)|all cancers(265;0.127)|COAD - Colon adenocarcinoma(174;0.201)|Lung(183;0.227)|Colorectal(144;0.241)		GATTTGGAGAGGTAAGTTTTC	0.358			NA											6	73					8.12818e-05	9.95791e-05	0.001984	1	0
AMY2B	280	broad.mit.edu	37	1	104116939	104116939	+	Missense_Mutation	SNP	G	G	T			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr1:104116939G>T	uc001duq.2	+	7	1418	c.802G>T	c.(802-804)GTG>TTG	p.V268L	AMY2B_uc010ouo.1_RNA|LOC648740_uc001dur.2_Missense_Mutation_p.V268L|AMY2B_uc001dus.1_5'Flank	NM_020978	NP_066188	P19961	AMY2B_HUMAN	amylase, pancreatic, alpha-2B precursor	268					carbohydrate metabolic process|digestion	extracellular region	alpha-amylase activity|metal ion binding				0		all_epithelial(167;3.05e-05)|all_lung(203;0.000199)|Lung NSC(277;0.000451)		Colorectal(144;0.0669)|all cancers(265;0.083)|Epithelial(280;0.094)|Lung(183;0.112)		AAATGGCCGGGTGACAGAATT	0.383			NA											22	557					8.24728e-16	1.36092e-15	0.004656	1	0
GPSM2	29899	broad.mit.edu	37	1	109445818	109445818	+	Missense_Mutation	SNP	A	A	G			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr1:109445818A>G	uc010ovc.1	+	9	1520	c.1024A>G	c.(1024-1026)ATG>GTG	p.M342V	AKNAD1_uc010ovb.1_Intron|GPSM2_uc010ovd.1_Missense_Mutation_p.M342V|GPSM2_uc010ove.1_Missense_Mutation_p.M342V	NM_013296	NP_037428	P81274	GPSM2_HUMAN	LGN protein	342	TPR 8.				G-protein coupled receptor protein signaling pathway	cell cortex|nucleus	GTPase activator activity|identical protein binding			central_nervous_system(1)	1		all_epithelial(167;7.64e-05)|all_lung(203;0.000321)|Lung NSC(277;0.000626)		Colorectal(144;0.0353)|Lung(183;0.0984)|COAD - Colon adenocarcinoma(174;0.129)|Epithelial(280;0.175)|all cancers(265;0.209)		TGATCAAGCAATGCATTTTGC	0.373			NA											3	33					0	0	0.004672	0	0
RSBN1	54665	broad.mit.edu	37	1	114354885	114354885	+	Silent	SNP	A	A	C			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr1:114354885A>C	uc001edq.2	-	1	186	c.150T>G	c.(148-150)GCT>GCG	p.A50A	RSBN1_uc001edr.2_RNA	NM_018364	NP_060834	Q5VWQ0	RSBN1_HUMAN	round spermatid basic protein 1	50						nucleus				ovary(1)	1	Lung SC(450;0.184)	all_cancers(81;3.78e-08)|all_epithelial(167;5.56e-08)|all_lung(203;6.97e-06)|Lung NSC(69;1.18e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		CGACCTGCGCAGCCATTTCAC	0.687			NA											9	116					0	0	0.001368	0	0
PPIAL4G	644591	broad.mit.edu	37	1	143767783	143767783	+	Missense_Mutation	SNP	G	G	C			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr1:143767783G>C	uc001ejt.2	-	1	99	c.66C>G	c.(64-66)ATC>ATG	p.I22M		NM_001123068	NP_001116540	A2BFH1	PAL4G_HUMAN	peptidylprolyl isomerase A (cyclophilin A)-like	22	PPIase cyclophilin-type.				protein folding	cytoplasm	peptidyl-prolyl cis-trans isomerase activity				0						CAAACTGTTTGATGGAGATGC	0.498			NA											5	473					0	0	0.001984	0	0
HIST2H2AC	8338	broad.mit.edu	37	1	149858839	149858839	+	Missense_Mutation	SNP	G	G	C			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr1:149858839G>C	uc001etd.2	+	1	315	c.315G>C	c.(313-315)CAG>CAC	p.Q105H	HIST2H2BE_uc001etc.2_5'Flank	NM_003517	NP_003508	Q16777	H2A2C_HUMAN	histone cluster 2, H2ac	105					nucleosome assembly	nucleosome|nucleus	DNA binding			ovary(1)|skin(1)	2	Breast(34;0.0124)|all_hematologic(923;0.127)		STAD - Stomach adenocarcinoma(528;0.133)|LUSC - Lung squamous cell carcinoma(543;0.221)			CCATCGCCCAGGGCGGCGTTT	0.522			NA											8	142					0	0	0.004482	0	0
HRNR	388697	broad.mit.edu	37	1	152193051	152193051	+	Nonsense_Mutation	SNP	C	C	A	rs140445785		TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr1:152193051C>A	uc001ezt.1	-	3	1130	c.1054G>T	c.(1054-1056)GAG>TAG	p.E352*		NM_001009931	NP_001009931	Q86YZ3	HORN_HUMAN	hornerin	352	3.				keratinization		calcium ion binding|protein binding			skin(2)|ovary(1)	3	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GAGCCAGACTCATGTTGCCCA	0.562			NA											37	180					1.96642e-18	3.30265e-18	0.006999	1	0
HRNR	388697	broad.mit.edu	37	1	152193307	152193307	+	Missense_Mutation	SNP	C	C	G			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr1:152193307C>G	uc001ezt.1	-	3	874	c.798G>C	c.(796-798)CAG>CAC	p.Q266H		NM_001009931	NP_001009931	Q86YZ3	HORN_HUMAN	hornerin	266	2.				keratinization		calcium ion binding|protein binding			skin(2)|ovary(1)	3	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CCCTAGATGACTGTCCTGACC	0.557			NA											25	700					0	0	0.00278	0	0
FLG	2312	broad.mit.edu	37	1	152276015	152276015	+	Missense_Mutation	SNP	G	G	A			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr1:152276015G>A	uc001ezu.1	-	3	11383	c.11347C>T	c.(11347-11349)CAC>TAC	p.H3783Y		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	3783	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GACCCTGAGTGTCCAGACCTA	0.567			NA							Ichthyosis				261	562					0	0	0.00361	0	0
FLG	2312	broad.mit.edu	37	1	152286475	152286475	+	Missense_Mutation	SNP	C	C	A			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr1:152286475C>A	uc001ezu.1	-	3	923	c.887G>T	c.(886-888)AGA>ATA	p.R296I	uc001ezv.2_RNA	NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	296	Filaggrin 1.|Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CTGGCTAACTCTGGATCCCCT	0.512			NA							Ichthyosis				85	557					2.75442e-36	4.73861e-36	0.00361	1	0
FLG2	388698	broad.mit.edu	37	1	152325867	152325867	+	Missense_Mutation	SNP	G	G	T			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr1:152325867G>T	uc001ezw.3	-	3	4468	c.4395C>A	c.(4393-4395)CAC>CAA	p.H1465Q	uc001ezv.2_Intron	NM_001014342	NP_001014364	Q5D862	FILA2_HUMAN	filaggrin family member 2	1465	Filaggrin 5.						calcium ion binding|structural molecule activity			ovary(10)|skin(5)|upper_aerodigestive_tract(1)|breast(1)	17	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GAGTAGTTCCGTGTCTCCCAT	0.502			NA											211	505					2.39235e-93	4.14089e-93	0.00361	1	0
CRNN	49860	broad.mit.edu	37	1	152382335	152382335	+	Missense_Mutation	SNP	G	G	T			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr1:152382335G>T	uc001ezx.2	-	3	1297	c.1223C>A	c.(1222-1224)GCA>GAA	p.A408E		NM_016190	NP_057274	Q9UBG3	CRNN_HUMAN	cornulin	408					cell-cell adhesion|response to heat	cytoplasm|membrane	calcium ion binding			ovary(2)|skin(1)	3	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			CTCAGTGCTTGCCCCAGTCTG	0.607			NA											37	92					9.17885e-22	1.56013e-21	0.003271	1	0
PGLYRP3	114771	broad.mit.edu	37	1	153270495	153270495	+	Missense_Mutation	SNP	G	G	T			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr1:153270495G>T	uc001fbn.1	-	7	1016	c.963C>A	c.(961-963)AAC>AAA	p.N321K		NM_052891	NP_443123	Q96LB9	PGRP3_HUMAN	peptidoglycan recognition protein 3 precursor	321					defense response to Gram-positive bacterium|detection of bacterium|innate immune response|peptidoglycan catabolic process	extracellular region|intracellular|membrane	N-acetylmuramoyl-L-alanine amidase activity|peptidoglycan receptor activity|zinc ion binding			ovary(2)|pancreas(1)|skin(1)	4	all_lung(78;3.35e-32)|Lung NSC(65;1.22e-30)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.171)			GGGACAGGATGTTGACCACGT	0.597			NA											57	237					4.96213e-28	8.51081e-28	0.00361	1	0
FCRL1	115350	broad.mit.edu	37	1	157771368	157771368	+	Splice_Site	SNP	C	C	A	rs148618017	by1000genomes	TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr1:157771368C>A	uc001frg.2	-	6	1000	c.887_splice	c.e6-1	p.V296_splice	FCRL1_uc001frf.2_Splice_Site|FCRL1_uc001frh.2_Splice_Site_p.V296_splice|FCRL1_uc001fri.2_Intron|FCRL1_uc001frj.2_RNA	NM_052938	NP_443170	Q96LA6	FCRL1_HUMAN	Fc receptor-like 1 isoform 1 precursor							integral to membrane|plasma membrane	receptor activity			skin(4)|ovary(3)	7	all_hematologic(112;0.0378)		LUSC - Lung squamous cell carcinoma(543;0.24)			CCAGTAGGCACTAGAGGGAGA	0.552	GBM(54;482 1003 11223 30131 35730)		NA											9	69					7.03913e-09	1.02158e-08	0.001368	1	0
OR10K2	391107	broad.mit.edu	37	1	158389821	158389821	+	Missense_Mutation	SNP	G	G	T			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr1:158389821G>T	uc010pii.1	-	1	836	c.836C>A	c.(835-837)ACT>AAT	p.T279N		NM_001004476	NP_001004476	Q6IF99	O10K2_HUMAN	olfactory receptor, family 10, subfamily K,	279	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(1)	1	all_hematologic(112;0.0378)					AGTTATAATAGTGTAGGATAC	0.378			NA											14	101					1.5842e-08	2.28157e-08	0.001855	1	0
OR10K2	391107	broad.mit.edu	37	1	158390091	158390091	+	Missense_Mutation	SNP	G	G	A			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr1:158390091G>A	uc010pii.1	-	1	566	c.566C>T	c.(565-567)TCT>TTT	p.S189F		NM_001004476	NP_001004476	Q6IF99	O10K2_HUMAN	olfactory receptor, family 10, subfamily K,	189	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(1)	1	all_hematologic(112;0.0378)					GTTATGGTGAGATGCCAGCTT	0.438			NA											4	79					0	0	0.000248	0	0
OR10R2	343406	broad.mit.edu	37	1	158450078	158450078	+	Silent	SNP	G	G	A			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr1:158450078G>A	uc010pik.1	+	1	411	c.411G>A	c.(409-411)GTG>GTA	p.V137V	uc001fso.1_RNA	NM_001004472	NP_001004472	Q8NGX6	O10R2_HUMAN	olfactory receptor, family 10, subfamily R,	137	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(2)|skin(1)	3	all_hematologic(112;0.0378)					TATTGGGTGTGATGGGTTATG	0.478			NA											17	455					0	0	0.008871	0	0
OR10R2	343406	broad.mit.edu	37	1	158450652	158450652	+	Missense_Mutation	SNP	G	G	T			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr1:158450652G>T	uc010pik.1	+	1	985	c.985G>T	c.(985-987)GGT>TGT	p.G329C	uc001fso.1_RNA	NM_001004472	NP_001004472	Q8NGX6	O10R2_HUMAN	olfactory receptor, family 10, subfamily R,	329	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(2)|skin(1)	3	all_hematologic(112;0.0378)					GGGCAAGAAAGGTTCTCTAAA	0.308			NA											11	43					6.42651e-13	1.02752e-12	0.000978	1	0
OR6Y1	391112	broad.mit.edu	37	1	158517803	158517803	+	Silent	SNP	G	G	T			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr1:158517803G>T	uc010pil.1	-	1	93	c.93C>A	c.(91-93)CTC>CTA	p.L31L		NM_001005189	NP_001005189	Q8NGX8	OR6Y1_HUMAN	olfactory receptor, family 6, subfamily Y,	31	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	all_hematologic(112;0.0378)					TGGAGAAAAAGAGAAGCTGGA	0.453			NA											18	73					5.03518e-11	7.74433e-11	0.007413	1	0
DCAF8	50717	broad.mit.edu	37	1	160210023	160210023	+	Missense_Mutation	SNP	C	C	T			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr1:160210023C>T	uc001fvo.2	-	4	499	c.187G>A	c.(187-189)GAA>AAA	p.E63K	DCAF8_uc001fvn.2_Missense_Mutation_p.E63K|DCAF8_uc009wth.2_Missense_Mutation_p.E63K|DCAF8_uc010pjb.1_Missense_Mutation_p.E63K|DCAF8_uc010pjc.1_Missense_Mutation_p.E217K|DCAF8_uc001fvq.3_Missense_Mutation_p.E63K|DCAF8_uc001fvp.3_Missense_Mutation_p.E63K|uc010pjd.1_3'UTR	NM_015726	NP_056541	Q5TAQ9	DCAF8_HUMAN	DDB1 and CUL4 associated factor 8	63						CUL4 RING ubiquitin ligase complex	protein binding			skin(2)	2						CCTCGACTTTCTGTGCTGGTG	0.522			NA											4	70					0	0	0.000602	0	0
NCSTN	23385	broad.mit.edu	37	1	160313247	160313247	+	Silent	SNP	C	C	T			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr1:160313247C>T	uc001fvx.2	+	1	185	c.61C>T	c.(61-63)CTG>TTG	p.L21L	COPA_uc009wti.2_5'UTR|COPA_uc001fvv.3_5'UTR|COPA_uc009wtj.1_5'UTR|NCSTN_uc009wtk.1_RNA|NCSTN_uc001fvy.2_5'UTR|NCSTN_uc010pjf.1_Silent_p.L21L	NM_015331	NP_056146	Q92542	NICA_HUMAN	nicastrin precursor	21					amyloid precursor protein catabolic process|apoptosis|induction of apoptosis by extracellular signals|membrane protein ectodomain proteolysis|membrane protein intracellular domain proteolysis|nerve growth factor receptor signaling pathway|Notch receptor processing|Notch signaling pathway|positive regulation of catalytic activity|protein processing	endoplasmic reticulum|Golgi apparatus|integral to plasma membrane|melanosome	protein binding			ovary(1)|lung(1)	2	all_cancers(52;8.15e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			CCTTCGCCTTCTGTCTTTCTG	0.667			NA											6	47					0	0	0.001168	0	0
SLAMF1	6504	broad.mit.edu	37	1	160604432	160604432	+	Missense_Mutation	SNP	G	G	T			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr1:160604432G>T	uc001fwl.3	-	3	1017	c.671C>A	c.(670-672)CCG>CAG	p.P224Q	SLAMF1_uc010pjk.1_RNA|SLAMF1_uc010pjl.1_RNA|SLAMF1_uc010pjm.1_RNA	NM_003037	NP_003028	Q13291	SLAF1_HUMAN	signaling lymphocytic activation molecule family	224	Extracellular (Potential).|Ig-like V-type.				interspecies interaction between organisms|lymphocyte activation|positive regulation of cell proliferation	integral to membrane	antigen binding|transmembrane receptor activity			ovary(1)|breast(1)	2	all_cancers(52;4.94e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.0175)			TCCGGGCCACGGGCTGAAGGT	0.577			NA											30	117					2.42023e-17	4.02897e-17	0.003271	1	0
ABL2	27	broad.mit.edu	37	1	179095584	179095584	+	Silent	SNP	C	C	A			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr1:179095584C>A	uc001gmj.3	-	4	902	c.615G>T	c.(613-615)GGG>GGT	p.G205G	ABL2_uc010pnf.1_Silent_p.G205G|ABL2_uc010png.1_Silent_p.G184G|ABL2_uc010pnh.1_Silent_p.G184G|ABL2_uc009wxe.2_Silent_p.G184G|ABL2_uc001gmg.3_Silent_p.G190G|ABL2_uc001gmi.3_Silent_p.G190G|ABL2_uc001gmh.3_Silent_p.G169G|ABL2_uc010pne.1_Silent_p.G169G|ABL2_uc009wxf.1_Silent_p.G190G|ABL2_uc001gmk.2_Silent_p.G169G	NM_007314	NP_009298	P42684	ABL2_HUMAN	arg tyrosine kinase isoform b	205	SH2.				axon guidance|cell adhesion|peptidyl-tyrosine phosphorylation|positive regulation of oxidoreductase activity|signal transduction	cytoskeleton|cytosol	ATP binding|magnesium ion binding|manganese ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding			lung(8)|breast(3)|ovary(2)|central_nervous_system(1)	14					Adenosine triphosphate(DB00171)|Dasatinib(DB01254)	TGGACAGCTGCCCAGGGCTAC	0.537			NA	T	ETV6	AML								27	84					2.79863e-10	4.19054e-10	0.004656	1	0
C1orf125	126859	broad.mit.edu	37	1	179497545	179497545	+	Missense_Mutation	SNP	A	A	T			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr1:179497545A>T	uc001gmo.2	+	23	2821	c.2694A>T	c.(2692-2694)GAA>GAT	p.E898D	C1orf125_uc009wxg.2_RNA|C1orf125_uc001gmp.2_Missense_Mutation_p.E824D|C1orf125_uc009wxh.2_RNA	NM_144696	NP_653297	Q5T1B0	AXDN1_HUMAN	hypothetical protein LOC126859 isoform 1	898	Glu-rich.										0						CTCTATTTGAAACAGATGTGT	0.348			NA											16	26					0	0	0.00499	0	0
CEP350	9857	broad.mit.edu	37	1	179989875	179989875	+	Missense_Mutation	SNP	G	G	T			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr1:179989875G>T	uc001gnt.2	+	12	3349	c.2966G>T	c.(2965-2967)AGT>ATT	p.S989I	CEP350_uc009wxl.2_Missense_Mutation_p.S988I|CEP350_uc001gnu.2_Missense_Mutation_p.S823I	NM_014810	NP_055625	Q5VT06	CE350_HUMAN	centrosome-associated protein 350	989						centrosome|nucleus|spindle				ovary(4)	4						CCTCTTCTTAGTGAGGGGAGT	0.433			NA											13	202					1.52009e-12	2.41677e-12	0.003163	1	0
GLT25D2	23127	broad.mit.edu	37	1	183909713	183909713	+	Splice_Site	SNP	A	A	T			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr1:183909713A>T	uc001gqr.2	-	11	1976	c.1604_splice	c.e11+1	p.V535_splice	GLT25D2_uc010poj.1_Splice_Site_p.V535_splice|GLT25D2_uc001gqp.2_Splice_Site_p.V143_splice|GLT25D2_uc001gqq.2_Splice_Site_p.V272_splice|GLT25D2_uc001gqs.2_Splice_Site_p.V415_splice	NM_015101	NP_055916	Q8IYK4	GT252_HUMAN	glycosyltransferase 25 domain containing 2						lipopolysaccharide biosynthetic process	endoplasmic reticulum lumen	procollagen galactosyltransferase activity			ovary(1)|breast(1)	2						AGGGAGACTCACACGGGATGC	0.483	Esophageal Squamous(10;42 606 18489 38825)		NA											8	87					0	0	0.004482	0	0
ASPM	259266	broad.mit.edu	37	1	197073257	197073257	+	Missense_Mutation	SNP	G	G	C			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr1:197073257G>C	uc001gtu.2	-	18	5381	c.5124C>G	c.(5122-5124)ATC>ATG	p.I1708M	ASPM_uc001gtv.2_Intron|ASPM_uc001gtw.3_Intron	NM_018136	NP_060606	Q8IZT6	ASPM_HUMAN	asp (abnormal spindle)-like, microcephaly	1708					mitosis	cytoplasm|nucleus	calmodulin binding			ovary(4)|central_nervous_system(2)	6						AACATTGCTGGATAAATAGTG	0.348			NA											3	118					0	0	0.004672	0	0
CAMSAP1L1	23271	broad.mit.edu	37	1	200819110	200819110	+	Silent	SNP	A	A	G			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr1:200819110A>G	uc001gvl.2	+	12	3516	c.3246A>G	c.(3244-3246)GAA>GAG	p.E1082E	CAMSAP1L1_uc001gvk.2_Silent_p.E1071E|CAMSAP1L1_uc001gvm.2_Silent_p.E1055E	NM_203459	NP_982284	Q08AD1	CAMP2_HUMAN	calmodulin regulated spectrin-associated protein	1082						cytoplasm|microtubule	protein binding			ovary(2)|large_intestine(1)|pancreas(1)	4						CAGTCTCTGAAGTCCTATCAC	0.443			NA											19	90					0	0	0.006122	0	0
IGFN1	91156	broad.mit.edu	37	1	201182572	201182572	+	Missense_Mutation	SNP	G	G	T			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr1:201182572G>T	uc001gwc.2	+	1	803	c.31G>T	c.(31-33)GGG>TGG	p.G11W	IGFN1_uc001gwb.2_Intron	NM_178275	NP_840059			RecName: Full=Immunoglobulin-like and fibronectin type III domain-containing protein 1; AltName: Full=EEF1A2-binding protein 1; AltName: Full=KY-interacting protein 1;											ovary(2)|pancreas(1)	3						AGAGAACTGGGGGTGCCTGGA	0.597			NA											5	45					0.000602214	0.000713082	0.000602	1	0
NAV1	89796	broad.mit.edu	37	1	201757598	201757598	+	Missense_Mutation	SNP	A	A	C			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr1:201757598A>C	uc001gwu.2	+	10	3345	c.2998A>C	c.(2998-3000)AGT>CGT	p.S1000R	NAV1_uc001gwv.1_Missense_Mutation_p.S508R|NAV1_uc001gww.1_Missense_Mutation_p.S609R|NAV1_uc001gwx.2_Missense_Mutation_p.S609R|NAV1_uc001gwy.1_Missense_Mutation_p.S381R	NM_020443	NP_065176	Q8NEY1	NAV1_HUMAN	neuron navigator 1	1000					cell differentiation|nervous system development	cytoplasm|microtubule	nucleoside-triphosphatase activity|nucleotide binding			central_nervous_system(3)|ovary(1)	4						ccttccAGTGAGTCCCACTGC	0.463			NA											9	88					0	0	0.006214	0	0
KCNK2	3776	broad.mit.edu	37	1	215342594	215342594	+	Missense_Mutation	SNP	C	C	G			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr1:215342594C>G	uc001hkq.2	+	4	697	c.528C>G	c.(526-528)ATC>ATG	p.I176M	KCNK2_uc001hko.2_Missense_Mutation_p.I172M|KCNK2_uc009xdm.2_RNA|KCNK2_uc001hkp.2_RNA|KCNK2_uc010pua.1_RNA|KCNK2_uc001hkr.3_Missense_Mutation_p.I161M	NM_001017425	NP_001017425	O95069	KCNK2_HUMAN	potassium channel, subfamily K, member 2 isoform	176	Helical; (Potential).						outward rectifier potassium channel activity				0				OV - Ovarian serous cystadenocarcinoma(81;0.0399)|all cancers(67;0.0556)|GBM - Glioblastoma multiforme(131;0.068)	Dofetilide(DB00204)	TCTGTATCATCTATGCCTTAC	0.249			NA											6	100					0	0	0.001984	0	0
TGFB2	7042	broad.mit.edu	37	1	218614594	218614594	+	Missense_Mutation	SNP	T	T	A			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr1:218614594T>A	uc001hlm.2	+	7	1788	c.1135T>A	c.(1135-1137)TGC>AGC	p.C379S	TGFB2_uc001hln.2_Missense_Mutation_p.C407S|TGFB2_uc010pue.1_RNA|TGFB2_uc001hlo.2_RNA	NM_003238	NP_003229	P61812	TGFB2_HUMAN	transforming growth factor, beta 2 isoform 2	379					activation of protein kinase activity|angiogenesis|cardiac epithelial to mesenchymal transition|cardiac muscle cell proliferation|cardioblast differentiation|catagen|cell cycle arrest|cell death|cell growth|cell-cell junction organization|cell-cell signaling|collagen fibril organization|dopamine biosynthetic process|embryonic digestive tract development|eye development|glial cell migration|hair follicle morphogenesis|hemopoiesis|menstrual cycle phase|negative regulation of alkaline phosphatase activity|negative regulation of cell growth|negative regulation of epithelial cell proliferation|negative regulation of immune response|negative regulation of macrophage cytokine production|neuron development|neutrophil chemotaxis|odontogenesis|pathway-restricted SMAD protein phosphorylation|platelet activation|platelet degranulation|positive regulation of cardioblast differentiation|positive regulation of catagen|positive regulation of cell adhesion mediated by integrin|positive regulation of cell cycle|positive regulation of cell division|positive regulation of cell growth|positive regulation of cell proliferation|positive regulation of epithelial cell migration|positive regulation of epithelial to mesenchymal transition|positive regulation of heart contraction|positive regulation of immune response|positive regulation of integrin biosynthetic process|positive regulation of neuron apoptosis|positive regulation of ossification|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of protein secretion|positive regulation of stress-activated MAPK cascade|regulation of transforming growth factor-beta2 production|response to hypoxia|response to progesterone stimulus|salivary gland morphogenesis|SMAD protein import into nucleus|somatic stem cell division|transforming growth factor beta receptor signaling pathway	axon|extracellular matrix|extracellular space|neuronal cell body|platelet alpha granule lumen	beta-amyloid binding|cytokine activity|growth factor activity|protein heterodimerization activity|protein homodimerization activity|receptor signaling protein serine/threonine kinase activity|type II transforming growth factor beta receptor binding				0				all cancers(67;0.0459)|OV - Ovarian serous cystadenocarcinoma(81;0.049)|GBM - Glioblastoma multiforme(131;0.0776)		TGCTTCTCCTTGCTGCGTGTC	0.408			NA											8	133					0	0	0.00308	0	0
IARS2	55699	broad.mit.edu	37	1	220287811	220287811	+	Missense_Mutation	SNP	C	C	G			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr1:220287811C>G	uc001hmc.2	+	12	1739	c.1635C>G	c.(1633-1635)ATC>ATG	p.I545M		NM_018060	NP_060530	Q9NSE4	SYIM_HUMAN	mitochondrial isoleucine tRNA synthetase	545					isoleucyl-tRNA aminoacylation	mitochondrial matrix	ATP binding|isoleucine-tRNA ligase activity			ovary(2)|skin(2)	4				GBM - Glioblastoma multiforme(131;0.0554)	L-Isoleucine(DB00167)	AATACTTGATCAACAGGTAGA	0.318			NA											20	97					0	0	0.008871	0	0
DUSP10	11221	broad.mit.edu	37	1	221912759	221912759	+	Missense_Mutation	SNP	T	T	A	rs148718278		TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr1:221912759T>A	uc001hmy.1	-	2	510	c.328A>T	c.(328-330)ACC>TCC	p.T110S	DUSP10_uc001hmx.1_5'Flank|DUSP10_uc001hmz.1_Intron	NM_007207	NP_009138	Q9Y6W6	DUS10_HUMAN	dual specificity phosphatase 10 isoform a	110					inactivation of MAPK activity|JNK cascade|negative regulation of JNK cascade|negative regulation of JUN kinase activity|negative regulation of stress-activated MAPK cascade	Golgi apparatus|nucleus	MAP kinase tyrosine/serine/threonine phosphatase activity|protein tyrosine phosphatase activity			upper_aerodigestive_tract(1)|lung(1)	2				GBM - Glioblastoma multiforme(131;0.0103)		GGGCAGGTGGTAGAGGTTCCG	0.572			NA											9	18					0	0	0.006214	0	0
DISP1	84976	broad.mit.edu	37	1	223178675	223178676	+	Missense_Mutation	DNP	GG	GG	TT			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr1:223178675_223178676GG>TT	uc001hnu.1	+	8	4083_4084	c.3936_3937GG>TT	c.(3934-3939)GTGGCA>GTTTCA	p.A1313S		NM_032890	NP_116279	Q96F81	DISP1_HUMAN	dispatched A	1313					diaphragm development|protein homotrimerization|regulation of protein secretion|smoothened signaling pathway	basolateral plasma membrane|integral to membrane	hedgehog receptor activity|peptide transporter activity				0				GBM - Glioblastoma multiforme(131;0.102)		AAAACGGCGTGGCACCTCTGAA	0.589			NA											19	82					0	0	0.004672	0	0
CDC42BPA	8476	broad.mit.edu	37	1	227257519	227257519	+	Missense_Mutation	SNP	C	C	G			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr1:227257519C>G	uc001hqr.2	-	21	3806	c.2863G>C	c.(2863-2865)GCA>CCA	p.A955P	CDC42BPA_uc001hqq.2_Missense_Mutation_p.A219P|CDC42BPA_uc001hqs.2_Missense_Mutation_p.A874P|CDC42BPA_uc009xes.2_Missense_Mutation_p.A955P|CDC42BPA_uc010pvs.1_Intron|CDC42BPA_uc001hqp.2_Missense_Mutation_p.A111P|CDC42BPA_uc001hqu.1_Missense_Mutation_p.A111P	NM_003607	NP_003598	Q5VT25	MRCKA_HUMAN	CDC42-binding protein kinase alpha isoform B	955					actin cytoskeleton reorganization|intracellular signal transduction	cell leading edge|cell-cell junction|cytoplasm	ATP binding|identical protein binding|magnesium ion binding|protein serine/threonine kinase activity|small GTPase regulator activity			lung(6)|breast(2)|stomach(1)|ovary(1)|pancreas(1)	11		all_cancers(173;0.156)|Prostate(94;0.0792)				TTCAAAAATGCCAAGAAAGAA	0.338			NA											3	48					0	0	0.000248	0	0
MRPL55	128308	broad.mit.edu	37	1	228294558	228294558	+	Missense_Mutation	SNP	T	T	C			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr1:228294558T>C	uc001hry.2	-	3	1034	c.290A>G	c.(289-291)GAG>GGG	p.E97G	MRPL55_uc001hrz.3_Missense_Mutation_p.E133G|MRPL55_uc009xex.2_Missense_Mutation_p.E97G|MRPL55_uc001hsa.3_Missense_Mutation_p.E97G|MRPL55_uc001hsb.3_Missense_Mutation_p.E97G|MRPL55_uc001hsc.3_Missense_Mutation_p.E97G|MRPL55_uc001hsd.3_Missense_Mutation_p.E97G|MRPL55_uc001hse.3_Missense_Mutation_p.E97G|MRPL55_uc001hsf.3_Missense_Mutation_p.E97G|MRPL55_uc001hsg.3_Missense_Mutation_p.E97G	NM_181465	NP_852130	Q7Z7F7	RM55_HUMAN	mitochondrial ribosomal protein L55 isoform a	97					translation	mitochondrial large ribosomal subunit	structural constituent of ribosome			central_nervous_system(1)	1		Prostate(94;0.0405)				GAGCTGAGCCTCACGCTTCCG	0.597			NA											6	64					0	0	0.001168	0	0
OBSCN	84033	broad.mit.edu	37	1	228479799	228479799	+	Missense_Mutation	SNP	G	G	T			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr1:228479799G>T	uc009xez.1	+	39	10584	c.10540G>T	c.(10540-10542)GAC>TAC	p.D3514Y	OBSCN_uc001hsn.2_Missense_Mutation_p.D3514Y|OBSCN_uc001hsq.1_Missense_Mutation_p.D770Y	NM_001098623	NP_001092093	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and	3514	Ig-like 35.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			stomach(8)|large_intestine(7)|breast(5)|ovary(4)|skin(2)|central_nervous_system(1)|pancreas(1)	28		Prostate(94;0.0405)				GGCCATGGCGGACGCCGGGGA	0.622			NA											22	92					2.89027e-11	4.45747e-11	0.002299	1	0
URB2	9816	broad.mit.edu	37	1	229771836	229771836	+	Silent	SNP	G	G	T			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr1:229771836G>T	uc001hts.1	+	4	1612	c.1476G>T	c.(1474-1476)TCG>TCT	p.S492S	URB2_uc009xfd.1_Silent_p.S492S	NM_014777	NP_055592	Q14146	URB2_HUMAN	URB2 ribosome biogenesis 2 homolog	492						nucleolus				central_nervous_system(2)|ovary(1)	3						TGCTGGCCTCGGGCCCCTCCA	0.577			NA											15	174					0.000422831	0.000507039	0.004007	1	0
PCNXL2	80003	broad.mit.edu	37	1	233225832	233225832	+	Missense_Mutation	SNP	C	C	A			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr1:233225832C>A	uc001hvl.2	-	23	4286	c.4051G>T	c.(4051-4053)GTG>TTG	p.V1351L	PCNXL2_uc001hvm.1_RNA|PCNXL2_uc009xfu.2_Intron	NM_014801	NP_055616	A6NKB5	PCX2_HUMAN	pecanex-like 2	1351						integral to membrane				central_nervous_system(1)|pancreas(1)	2		all_cancers(173;0.0347)|Prostate(94;0.137)				CAGAATTTCACTGGCCTGACA	0.423			NA											22	64					2.70639e-06	3.59582e-06	0.002299	1	0
EXO1	9156	broad.mit.edu	37	1	242042435	242042435	+	Silent	SNP	C	C	T			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr1:242042435C>T	uc001hzh.2	+	13	2439	c.1899C>T	c.(1897-1899)TTC>TTT	p.F633F	EXO1_uc001hzi.2_Silent_p.F633F|EXO1_uc001hzj.2_Silent_p.F633F|EXO1_uc009xgq.2_Silent_p.F632F	NM_130398	NP_569082	Q9UQ84	EXO1_HUMAN	exonuclease 1 isoform b	633	Interaction with MSH2.				meiosis|mismatch repair	nucleus	double-stranded DNA specific 5'-3' exodeoxyribonuclease activity|flap endonuclease activity|metal ion binding|protein binding|protein binding|ribonuclease H activity|single-stranded DNA specific 5'-3' exodeoxyribonuclease activity			ovary(2)|lung(2)|skin(1)	5	Ovarian(103;0.103)	all_cancers(173;0.0555)	OV - Ovarian serous cystadenocarcinoma(106;0.0107)			TGCAGCAGTTCCGAAGAAAGA	0.488			NA						Direct_reversal_of_damage|Editing_and_processing_nucleases					8	94					0	0	0.00308	0	0
OR2T33	391195	broad.mit.edu	37	1	248436663	248436663	+	Missense_Mutation	SNP	C	C	G			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr1:248436663C>G	uc010pzi.1	-	1	454	c.454G>C	c.(454-456)GCT>CCT	p.A152P		NM_001004695	NP_001004695	Q8NG76	O2T33_HUMAN	olfactory receptor, family 2, subfamily T,	152	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(1)|ovary(1)	2	all_cancers(71;0.000124)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			AGCCCGTCAGCTGCACCCAGG	0.587			NA											23	126					0	0	0.007291	0	0
OR2T4	127074	broad.mit.edu	37	1	248525228	248525228	+	Missense_Mutation	SNP	G	G	T			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr1:248525228G>T	uc001ieh.1	+	1	346	c.346G>T	c.(346-348)GAC>TAC	p.D116Y		NM_001004696	NP_001004696	Q8NH00	OR2T4_HUMAN	olfactory receptor, family 2, subfamily T,	116	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			GATGCTCCTGGACCAGGTCAT	0.498			NA											19	333					4.96729e-08	6.99375e-08	0.008871	1	0
TUBB8	347688	broad.mit.edu	37	10	93572	93573	+	Missense_Mutation	DNP	CC	CC	AG			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr10:93572_93573CC>AG	uc001ifi.2	-	4	759_760	c.759_760GG>CT	c.(757-762)CTGGCC>CTCTCC	p.A254S	TUBB8_uc009xhe.2_Missense_Mutation_p.A217S|TUBB8_uc010pzs.1_Missense_Mutation_p.A182S	NM_177987	NP_817124	Q3ZCM7	TBB8_HUMAN	tubulin, beta 8 isoform 1	254					microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|structural molecule activity			ovary(1)	1		all_cancers(4;0.00131)|all_lung(4;0.000777)|Lung NSC(4;0.0043)|all_epithelial(10;0.0154)|Colorectal(49;0.235)		Epithelial(11;0.00341)|all cancers(11;0.00922)|OV - Ovarian serous cystadenocarcinoma(14;0.0508)|Lung(33;0.132)		ATGTTCACGGCCAGCTTCCGCA	0.639	Pancreas(192;2041 3010 9013 18103)		NA											4	41					0	0	0.004672	0	0
ARMC3	219681	broad.mit.edu	37	10	23270395	23270395	+	Missense_Mutation	SNP	G	G	T			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr10:23270395G>T	uc001irm.3	+	9	1126	c.1043G>T	c.(1042-1044)GGC>GTC	p.G348V	ARMC3_uc010qcv.1_Missense_Mutation_p.G348V|ARMC3_uc010qcw.1_Missense_Mutation_p.G85V	NM_173081	NP_775104	Q5W041	ARMC3_HUMAN	armadillo repeat containing 3	348	ARM 9.						binding				0						GAGAATTCAGGCAGCAAAGAT	0.373			NA											11	64					9.31168e-06	1.20604e-05	0.001855	1	0
ENKUR	219670	broad.mit.edu	37	10	25284575	25284575	+	Missense_Mutation	SNP	C	C	G			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr10:25284575C>G	uc001isg.1	-	3	612	c.447G>C	c.(445-447)AAG>AAC	p.K149N	ENKUR_uc001ish.1_Missense_Mutation_p.K87N	NM_145010	NP_659447	Q8TC29	ENKUR_HUMAN	enkurin	149						cilium|flagellum	calmodulin binding|SH3 domain binding				0						ACAAGGCTACCTTTTTATTGA	0.338			NA											33	155					0	0	0.002096	0	0
MYO3A	53904	broad.mit.edu	37	10	26463396	26463396	+	Missense_Mutation	SNP	G	G	T			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr10:26463396G>T	uc001isn.2	+	30	4563	c.4203G>T	c.(4201-4203)GAG>GAT	p.E1401D	MYO3A_uc009xkp.1_Intron|MYO3A_uc009xkq.1_Intron	NM_017433	NP_059129	Q8NEV4	MYO3A_HUMAN	myosin IIIA	1401					protein autophosphorylation|response to stimulus|sensory perception of sound|visual perception	cytoplasm|filamentous actin|filopodium|myosin complex	actin binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|plus-end directed microfilament motor activity|protein serine/threonine kinase activity			ovary(6)|stomach(3)|lung(3)|central_nervous_system(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	18						CAAAACATGAGGAAATCAATA	0.358			NA											21	92					1.55795e-14	2.5412e-14	0.001882	1	0
CSGALNACT2	55454	broad.mit.edu	37	10	43650878	43650878	+	Missense_Mutation	SNP	G	G	T	rs150048164		TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr10:43650878G>T	uc001jan.2	+	2	616	c.281G>T	c.(280-282)CGG>CTG	p.R94L	CSGALNACT2_uc001jam.1_Missense_Mutation_p.R94L	NM_018590	NP_061060	Q8N6G5	CGAT2_HUMAN	chondroitin sulfate	94	Lumenal (Potential).|Potential.				chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process|dermatan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process	Golgi cisterna membrane|integral to Golgi membrane	glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity|metal ion binding			ovary(1)	1						GAGAAGATGCGGTCACTGCAA	0.423			NA											14	46					1.05317e-09	1.55638e-09	0.00245	1	0
GDF2	2658	broad.mit.edu	37	10	48414410	48414410	+	Missense_Mutation	SNP	T	T	C			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr10:48414410T>C	uc001jfa.1	-	2	621	c.458A>G	c.(457-459)TAT>TGT	p.Y153C		NM_016204	NP_057288	Q9UK05	GDF2_HUMAN	growth differentiation factor 2 precursor	153					activin receptor signaling pathway|BMP signaling pathway|cartilage development|cellular iron ion homeostasis|growth|negative regulation of angiogenesis|negative regulation of blood vessel endothelial cell migration|negative regulation of cell growth|negative regulation of DNA replication|negative regulation of endothelial cell proliferation|ossification|pathway-restricted SMAD protein phosphorylation|patterning of blood vessels|positive regulation of angiogenesis|positive regulation of endothelial cell proliferation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of transcription, DNA-dependent	extracellular space	cytokine activity|growth factor activity			ovary(2)|skin(1)	3						ACAGGAGACATAGAGTCGGAG	0.493			NA											9	56					0	0	0.004482	0	0
DNA2	1763	broad.mit.edu	37	10	70231550	70231550	+	Missense_Mutation	SNP	C	C	G			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr10:70231550C>G	uc001jof.2	-	1	330	c.330G>C	c.(328-330)GAG>GAC	p.E110D	DNA2_uc001jog.1_Missense_Mutation_p.E24D|DNA2_uc001joh.1_RNA	NM_001080449	NP_001073918	P51530	DNA2L_HUMAN	DNA replication helicase 2 homolog	24					base-excision repair|DNA replication, removal of RNA primer|mitochondrial DNA repair|mitochondrial DNA replication|positive regulation of DNA replication|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication	mitochondrial nucleoid|nucleoplasm	5'-flap endonuclease activity|ATP binding|ATP-dependent DNA helicase activity|DNA binding|site-specific endodeoxyribonuclease activity, specific for altered base				0						CCGCTCACAGCTCCGCCGGCA	0.632			NA											4	29					0	0	0.000248	0	0
KIAA1274	27143	broad.mit.edu	37	10	72292490	72292490	+	Silent	SNP	G	G	C			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr10:72292490G>C	uc001jrd.3	+	6	1028	c.747G>C	c.(745-747)GTG>GTC	p.V249V		NM_014431	NP_055246	Q9ULE6	PALD_HUMAN	KIAA1274	249										ovary(2)|central_nervous_system(1)	3						ACTTGCATGTGACGGAGGAGG	0.627			NA											15	103					0	0	0.00499	0	0
PRF1	5551	broad.mit.edu	37	10	72360525	72360525	+	Missense_Mutation	SNP	C	C	A			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr10:72360525C>A	uc009xqg.2	-	2	295	c.134G>T	c.(133-135)GGG>GTG	p.G45V	PRF1_uc001jrf.3_Missense_Mutation_p.G45V	NM_001083116	NP_001076585	P14222	PERF_HUMAN	perforin 1 precursor	45	MACPF.				apoptosis|cellular defense response|cytolysis|defense response to tumor cell|defense response to virus|immune response to tumor cell|protein homooligomerization	cytolytic granule|endosome lumen|extracellular region|integral to membrane|plasma membrane	calcium ion binding|protein binding|wide pore channel activity			large_intestine(1)|ovary(1)|central_nervous_system(1)	3						CACACCCTCCCCGGCCAGCCA	0.677			NA	M			various leukaemia|lymphoma	Type 2 familial hemophagocytic lymphohistiocytosis		Familial_Hemophagocytic_Lymphohistiocytosis				7	58					0.00307968	0.0035357	0.00308	1	0
CDH23	64072	broad.mit.edu	37	10	73548714	73548714	+	Silent	SNP	G	G	C			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr10:73548714G>C	uc001jrx.3	+	43	6215	c.5838G>C	c.(5836-5838)CTG>CTC	p.L1946L		NM_022124	NP_071407	Q9H251	CAD23_HUMAN	cadherin-like 23 isoform 1 precursor	1946	Cadherin 18.|Extracellular (Potential).				calcium ion transport|calcium-dependent cell-cell adhesion|cytosolic calcium ion homeostasis|equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	cytosol|integral to membrane|plasma membrane|stereocilium	calcium ion binding|protein binding			central_nervous_system(5)|large_intestine(4)|ovary(2)	11						ACTTGCTTCTGATCTTCCTTT	0.557			NA											9	40					0	0	0.004482	0	0
CDH23	64072	broad.mit.edu	37	10	73548780	73548780	+	Silent	SNP	G	G	A			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr10:73548780G>A	uc001jrx.3	+	43	6281	c.5904G>A	c.(5902-5904)GTG>GTA	p.V1968V		NM_022124	NP_071407	Q9H251	CAD23_HUMAN	cadherin-like 23 isoform 1 precursor	1968	Cadherin 19.|Extracellular (Potential).				calcium ion transport|calcium-dependent cell-cell adhesion|cytosolic calcium ion homeostasis|equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	cytosol|integral to membrane|plasma membrane|stereocilium	calcium ion binding|protein binding			central_nervous_system(5)|large_intestine(4)|ovary(2)	11						AGGCAGAGGTGATGGAAAACT	0.567			NA											10	34					0	0	0.001368	0	0
PDE6C	5146	broad.mit.edu	37	10	95421882	95421882	+	Missense_Mutation	SNP	C	C	A			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr10:95421882C>A	uc001kiu.3	+	19	2413	c.2275C>A	c.(2275-2277)CAA>AAA	p.Q759K		NM_006204	NP_006195	P51160	PDE6C_HUMAN	phosphodiesterase 6C	759					visual perception	plasma membrane	3',5'-cyclic-GMP phosphodiesterase activity|cGMP binding|metal ion binding			ovary(2)|kidney(1)|skin(1)	4		Colorectal(252;0.123)				GTTGCAGCAACAACCCATTGT	0.294			NA											3	44					0.004672	0.00530994	0.004672	1	0
CYP2C19	1557	broad.mit.edu	37	10	96612523	96612523	+	Missense_Mutation	SNP	G	G	T	rs138112316		TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr10:96612523G>T	uc010qnz.1	+	9	1325	c.1325G>T	c.(1324-1326)CGC>CTC	p.R442L	CYP2C19_uc010qny.1_Missense_Mutation_p.R420L	NM_000769	NP_000760	P33261	CP2CJ_HUMAN	cytochrome P450, family 2, subfamily C,	442			R -> C (in allele CYP2C19*16; lowered catalytic activity).		exogenous drug catabolic process|heterocycle metabolic process|monoterpenoid metabolic process|steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	(S)-limonene 6-monooxygenase activity|(S)-limonene 7-monooxygenase activity|4-hydroxyacetophenone monooxygenase activity|electron carrier activity|enzyme binding|heme binding|oxygen binding|steroid hydroxylase activity			ovary(4)|central_nervous_system(1)|skin(1)	6		Colorectal(252;0.09)		all cancers(201;6.02e-07)|KIRC - Kidney renal clear cell carcinoma(50;0.0672)|Kidney(138;0.0838)	Adinazolam(DB00546)|Aminophenazone(DB01424)|Amitriptyline(DB00321)|Amoxicillin(DB01060)|Arformoterol(DB01274)|Bortezomib(DB00188)|Carisoprodol(DB00395)|Chlorzoxazone(DB00356)|Cilostazol(DB01166)|Citalopram(DB00215)|Clarithromycin(DB01211)|Clobazam(DB00349)|Desipramine(DB01151)|Desloratadine(DB00967)|Diclofenac(DB00586)|Diltiazem(DB00343)|Efavirenz(DB00625)|Esomeprazole(DB00736)|Famotidine(DB00927)|Felbamate(DB00949)|Finasteride(DB01216)|Flunitrazepam(DB01544)|Fluvoxamine(DB00176)|Formoterol(DB00983)|Fosphenytoin(DB01320)|Guanfacine(DB01018)|Imipramine(DB00458)|Indomethacin(DB00328)|Ketoconazole(DB01026)|Lansoprazole(DB00448)|Lapatinib(DB01259)|Loratadine(DB00455)|Melatonin(DB01065)|Mephenytoin(DB00532)|Methadone(DB00333)|Methylphenobarbital(DB00849)|Moclobemide(DB01171)|Modafinil(DB00745)|Nelfinavir(DB00220)|Nicardipine(DB00622)|Nilutamide(DB00665)|Norgestrel(DB00506)|Omeprazole(DB00338)|Oxcarbazepine(DB00776)|Pantoprazole(DB00213)|Pentamidine(DB00738)|Phenobarbital(DB01174)|Phenytoin(DB00252)|Primidone(DB00794)|Progesterone(DB00396)|Proguanil(DB01131)|Promazine(DB00420)|Quinidine(DB00908)|Rabeprazole(DB01129)|Ranitidine(DB00863)|Ritonavir(DB00503)|Selegiline(DB01037)|Sertraline(DB01104)|Temazepam(DB00231)|Teniposide(DB00444)|Terfenadine(DB00342)|Thalidomide(DB01041)|Thioridazine(DB00679)|Ticlopidine(DB00208)|Tolbutamide(DB01124)|Topiramate(DB00273)|Tranylcypromine(DB00752)|Troglitazone(DB00197)|Troleandomycin(DB01361)|Voriconazole(DB00582)	GGCCTGGCCCGCATGGAGCTG	0.433			NA											8	112					7.48243e-07	1.01075e-06	0.006214	1	0
MGEA5	10724	broad.mit.edu	37	10	103547259	103547259	+	Missense_Mutation	SNP	C	C	T			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr10:103547259C>T	uc001ktv.2	-	15	2919	c.2476G>A	c.(2476-2478)GAA>AAA	p.E826K	MGEA5_uc001ktu.2_RNA|MGEA5_uc010qqe.1_Missense_Mutation_p.E773K|MGEA5_uc009xws.2_Missense_Mutation_p.E759K	NM_012215	NP_036347	O60502	NCOAT_HUMAN	meningioma expressed antigen 5 (hyaluronidase)	826	Histone acetyltransferase activity (By similarity).				glycoprotein catabolic process	cytoplasm|nucleus	histone acetyltransferase activity|hyalurononglucosaminidase activity			ovary(2)|skin(1)	3		Colorectal(252;0.207)		Epithelial(162;4.67e-09)|all cancers(201;2.54e-07)		TCCTGTTCTTCATGGAAACTC	0.363			NA											6	90					0	0	0.001168	0	0
PNLIP	5406	broad.mit.edu	37	10	118314905	118314905	+	Nonsense_Mutation	SNP	G	G	T			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr10:118314905G>T	uc001lcm.2	+	8	740	c.697G>T	c.(697-699)GGA>TGA	p.G233*		NM_000936	NP_000927	P16233	LIPP_HUMAN	pancreatic lipase precursor	233					lipid catabolic process|retinoid metabolic process|steroid metabolic process	extracellular region	retinyl-palmitate esterase activity|triglyceride lipase activity			ovary(1)|central_nervous_system(1)|skin(1)	3				all cancers(201;0.0131)	Bentiromide(DB00522)|Orlistat(DB01083)	TTCAGGGTTTGGAATGAGCCA	0.423			NA											6	73					0.00198382	0.0022822	0.001984	1	0
FAM45A	404636	broad.mit.edu	37	10	120889070	120889070	+	Silent	SNP	A	A	C			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr10:120889070A>C	uc001ldw.2	+	7	782	c.738A>C	c.(736-738)CCA>CCC	p.P246P	FAM45A_uc010qsv.1_Silent_p.P238P|FAM45A_uc010qsw.1_Silent_p.P95P|FAM45A_uc010qsx.1_RNA|FAM45A_uc010qsy.1_Silent_p.P173P|FAM45A_uc010qsz.1_Silent_p.P135P	NM_207009	NP_996892	Q8TCE6	FA45A_HUMAN	hypothetical protein LOC404636	246										ovary(1)	1		Lung NSC(174;0.094)|all_lung(145;0.123)		all cancers(201;0.0293)		GCAACAGACCAGACCTCTATG	0.433			NA											4	53					0	0	0.000248	0	0
MKI67	4288	broad.mit.edu	37	10	129905011	129905011	+	Missense_Mutation	SNP	C	C	G			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr10:129905011C>G	uc001lke.2	-	13	5288	c.5093G>C	c.(5092-5094)AGA>ACA	p.R1698T	MKI67_uc001lkf.2_Missense_Mutation_p.R1338T|MKI67_uc009yav.1_Missense_Mutation_p.R1273T|MKI67_uc009yaw.1_Missense_Mutation_p.R848T	NM_002417	NP_002408	P46013	KI67_HUMAN	antigen identified by monoclonal antibody Ki-67	1698	6.|16 X 122 AA approximate repeats.				cell proliferation	nucleolus	ATP binding|protein C-terminus binding			ovary(4)|central_nervous_system(2)|skin(1)	7		all_epithelial(44;2.12e-05)|all_lung(145;0.00679)|Lung NSC(174;0.00998)|all_neural(114;0.0936)|Colorectal(57;0.14)|Breast(234;0.166)|Melanoma(40;0.203)				CTTAGGAGTTCTCAGCTGCCT	0.478			NA											9	76					0	0	0.004482	0	0
MKI67	4288	broad.mit.edu	37	10	129913540	129913540	+	Missense_Mutation	SNP	C	C	A			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr10:129913540C>A	uc001lke.2	-	7	1327	c.1132G>T	c.(1132-1134)GGT>TGT	p.G378C	MKI67_uc001lkf.2_Intron|MKI67_uc009yav.1_Intron|MKI67_uc009yaw.1_Intron	NM_002417	NP_002408	P46013	KI67_HUMAN	antigen identified by monoclonal antibody Ki-67	378					cell proliferation	nucleolus	ATP binding|protein C-terminus binding			ovary(4)|central_nervous_system(2)|skin(1)	7		all_epithelial(44;2.12e-05)|all_lung(145;0.00679)|Lung NSC(174;0.00998)|all_neural(114;0.0936)|Colorectal(57;0.14)|Breast(234;0.166)|Melanoma(40;0.203)				TCACTTTTACCCAGATTCACA	0.398			NA											12	131					1.61879e-10	2.4368e-10	0.001368	1	0
JAKMIP3	282973	broad.mit.edu	37	10	133948583	133948583	+	Missense_Mutation	SNP	G	G	T			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr10:133948583G>T	uc001lkx.3	+	4	888	c.888G>T	c.(886-888)CAG>CAT	p.Q296H		NM_001105521	NP_001098991			Janus kinase and microtubule interacting protein											breast(1)	1		all_cancers(35;5.63e-09)|all_epithelial(44;9.25e-07)|Lung NSC(174;0.0108)|all_lung(145;0.0173)|Colorectal(31;0.0721)|all_neural(114;0.0726)|Breast(234;0.0949)|Glioma(114;0.172)|Melanoma(40;0.175)		OV - Ovarian serous cystadenocarcinoma(35;0.000104)|Epithelial(32;0.000142)|all cancers(32;0.000185)|BRCA - Breast invasive adenocarcinoma(275;0.224)		GGCGCTTCCAGCTTAAAATCG	0.512			NA											5	40					0.000602214	0.000713082	0.000602	1	0
FRG2B	441581	broad.mit.edu	37	10	135440223	135440223	+	Silent	SNP	G	G	T			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr10:135440223G>T	uc010qvg.1	-	1	77	c.24C>A	c.(22-24)CCC>CCA	p.P8P		NM_001080998	NP_001074467	Q96QU4	FRG2B_HUMAN	FSHD region gene 2 family, member B	8						nucleus					0		all_cancers(35;7.01e-07)|all_epithelial(44;1.45e-05)|Lung NSC(174;0.027)|all_lung(145;0.0384)|all_neural(114;0.0726)|Glioma(114;0.172)|Melanoma(40;0.175)		OV - Ovarian serous cystadenocarcinoma(35;1.12e-06)|all cancers(32;1.43e-06)|Epithelial(32;1.71e-06)		AGTGGAGATCGGGGTCTTCAT	0.507			NA											6	316					2.62699e-14	4.27263e-14	0.003163	1	0
MUC5B	727897	broad.mit.edu	37	11	1263496	1263496	+	Missense_Mutation	SNP	G	G	A			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr11:1263496G>A	uc009ycr.1	+	47	7591	c.7465G>A	c.(7465-7467)GTG>ATG	p.V2489M	MUC5B_uc001ltb.2_Missense_Mutation_p.V1799M	NM_017511	NP_059981	Q9HC84	MUC5B_HUMAN	SubName: Full=Mucin 5AC, oligomeric mucus/gel-forming;	1796	7 X Cys-rich subdomain repeats.|Thr-rich.|Cys-rich subdomain 3.				cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding				0		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		GTGGTTTGACGTGGACTTCCC	0.572			NA											7	61					0	0	0.00308	0	0
OR51G1	79324	broad.mit.edu	37	11	4944910	4944910	+	Nonsense_Mutation	SNP	G	G	T			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr11:4944910G>T	uc010qyr.1	-	1	660	c.660C>A	c.(658-660)TAC>TAA	p.Y220*		NM_001005237	NP_001005237	Q8NGK1	O51G1_HUMAN	olfactory receptor, family 51, subfamily G,	220	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;2.58e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0284)|LUSC - Lung squamous cell carcinoma(625;0.19)		GGATGAGGGCGTATGAGAGAA	0.547			NA											13	57					4.36969e-10	6.49146e-10	0.001855	1	0
OR52E2	119678	broad.mit.edu	37	11	5080148	5080148	+	Missense_Mutation	SNP	T	T	A			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr11:5080148T>A	uc010qyw.1	-	1	710	c.710A>T	c.(709-711)AAG>ATG	p.K237M		NM_001005164	NP_001005164	Q8NGJ4	O52E2_HUMAN	olfactory receptor, family 52, subfamily E,	237	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3		Medulloblastoma(188;0.0061)|all_neural(188;0.0479)|Breast(177;0.086)		Epithelial(150;1.03e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)|LUSC - Lung squamous cell carcinoma(625;0.191)		GCTGAGGGACTTGAGTCGGGC	0.453			NA											16	47					0	0	0.004007	0	0
APBB1	322	broad.mit.edu	37	11	6423818	6423818	+	Silent	SNP	C	C	A			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr11:6423818C>A	uc001mdb.1	-	7	1342	c.1242G>T	c.(1240-1242)GGG>GGT	p.G414G	APBB1_uc001mcz.1_Silent_p.G35G|APBB1_uc001mdd.3_Silent_p.G194G|APBB1_uc001mda.2_Intron|APBB1_uc001mdc.1_Silent_p.G414G|APBB1_uc010rab.1_5'Flank|APBB1_uc010rac.1_5'Flank|APBB1_uc010rad.1_Silent_p.G35G|APBB1_uc010rae.1_Silent_p.G179G|APBB1_uc010raf.1_Silent_p.G155G|APBB1_uc009yfa.2_Silent_p.G155G|APBB1_uc009yey.2_Silent_p.G155G|APBB1_uc010rag.1_Silent_p.G155G|APBB1_uc009yfb.2_Silent_p.G155G|APBB1_uc001mde.2_Silent_p.G155G|APBB1_uc010rah.1_Silent_p.G155G	NM_001164	NP_001155	O00213	APBB1_HUMAN	amyloid beta A4 precursor protein-binding,	414	PID 1.				apoptosis|axonogenesis|cell cycle arrest|histone H4 acetylation|negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|negative regulation of thymidylate synthase biosynthetic process|positive regulation of apoptosis|positive regulation of transcription, DNA-dependent|response to DNA damage stimulus|signal transduction|transcription, DNA-dependent	cytoplasm|growth cone|lamellipodium|nucleus|plasma membrane|synapse	beta-amyloid binding|chromatin binding|histone binding|proline-rich region binding|transcription factor binding			breast(2)	2		Medulloblastoma(188;0.00263)|all_neural(188;0.026)|Breast(177;0.029)		Epithelial(150;6.49e-08)|BRCA - Breast invasive adenocarcinoma(625;0.194)		CCCCCCAGCCCCCAGACATGG	0.582	GBM(147;1810 2556 5672 39622)		NA											22	86					1.50039e-11	2.32663e-11	0.001882	1	0
HPX	3263	broad.mit.edu	37	11	6458780	6458780	+	Missense_Mutation	SNP	T	T	C			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr11:6458780T>C	uc001mdg.2	-	6	654	c.593A>G	c.(592-594)TAC>TGC	p.Y198C	HPX_uc001mdf.2_5'UTR|HPX_uc009yfc.2_RNA	NM_000613	NP_000604	P02790	HEMO_HUMAN	hemopexin precursor	198	Hemopexin-like 3.				cellular iron ion homeostasis|interspecies interaction between organisms	extracellular space	heme transporter activity|metal ion binding|protein binding				0		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;5.46e-08)|BRCA - Breast invasive adenocarcinoma(625;0.19)		GAAGCAGTAGTAGCGGCCCAG	0.617			NA											10	46					0	0	0.006214	0	0
ZNF214	7761	broad.mit.edu	37	11	7022175	7022175	+	Missense_Mutation	SNP	A	A	G			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr11:7022175A>G	uc001mfa.2	-	3	1042	c.739T>C	c.(739-741)TGT>CGT	p.C247R	ZNF214_uc010ray.1_Missense_Mutation_p.C247R|ZNF214_uc009yfh.1_Missense_Mutation_p.C247R	NM_013249	NP_037381	Q9UL59	ZN214_HUMAN	zinc finger protein 214	247					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1				Epithelial(150;3.87e-08)|BRCA - Breast invasive adenocarcinoma(625;0.081)		GAGCATTGACAGAGGTTTTCT	0.383	Ovarian(22;251 657 736 21522 46864)		NA											11	113					0	0	0.001368	0	0
PLEKHA7	144100	broad.mit.edu	37	11	16838765	16838765	+	Missense_Mutation	SNP	C	C	A			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr11:16838765C>A	uc001mmo.2	-	11	1463	c.1448G>T	c.(1447-1449)GGC>GTC	p.G483V	PLEKHA7_uc010rcu.1_Missense_Mutation_p.G483V|PLEKHA7_uc010rcv.1_Missense_Mutation_p.G57V|PLEKHA7_uc001mmn.2_Missense_Mutation_p.G191V	NM_175058	NP_778228	Q6IQ23	PKHA7_HUMAN	pleckstrin homology domain containing, family A	483					epithelial cell-cell adhesion|zonula adherens maintenance	centrosome|zonula adherens	delta-catenin binding			skin(2)|central_nervous_system(1)	3						TGGCGAGGAGCCCCCCGAGGG	0.637			NA											24	104					3.6726e-16	6.07805e-16	0.003954	1	0
SAA2	6289	broad.mit.edu	37	11	18269519	18269519	+	Missense_Mutation	SNP	G	G	C			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr11:18269519G>C	uc001mnz.3	-	2	77	c.40C>G	c.(40-42)CTG>GTG	p.L14V	SAA2_uc009yhj.2_Missense_Mutation_p.L14V	NM_030754	NP_110381	P02735	SAA_HUMAN	serum amyloid A2 isoform a	14					acute-phase response|elevation of cytosolic calcium ion concentration|innate immune response|lymphocyte chemotaxis|macrophage chemotaxis|negative regulation of inflammatory response|neutrophil chemotaxis|platelet activation|positive regulation of cell adhesion|positive regulation of interleukin-1 secretion	high-density lipoprotein particle	G-protein-coupled receptor binding				0					Human Serum Albumin(DB00062)|Serum albumin iodonated(DB00064)	CTGACACTCAGGACCAAGGAG	0.522			NA											15	80					0	0	0.003163	0	0
DCDC1	341019	broad.mit.edu	37	11	31329387	31329387	+	Missense_Mutation	SNP	C	C	A			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr11:31329387C>A	uc001msv.2	-	4	435	c.233G>T	c.(232-234)GGC>GTC	p.G78V	DCDC1_uc001msu.1_5'UTR	NM_181807	NP_861523	P59894	DCDC1_HUMAN	doublecortin domain containing 1	78					intracellular signal transduction					skin(1)	1	Lung SC(675;0.225)					TCTGTTGGGGCCAAACTGAGA	0.413			NA											33	155					1.56442e-22	2.66705e-22	0.002445	1	0
OR4C13	283092	broad.mit.edu	37	11	49974366	49974366	+	Missense_Mutation	SNP	C	C	A			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr11:49974366C>A	uc010rhz.1	+	1	392	c.392C>A	c.(391-393)ACC>AAC	p.T131N		NM_001001955	NP_001001955	Q8NGP0	OR4CD_HUMAN	olfactory receptor, family 4, subfamily C,	131	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(3)|ovary(1)	4						TTGCACTATACCACCGTCATG	0.458			NA											13	83					0.00010058	0.000122955	0.001368	1	0
OR4C46	119749	broad.mit.edu	37	11	51515475	51515475	+	Missense_Mutation	SNP	C	C	A			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr11:51515475C>A	uc010ric.1	+	1	194	c.194C>A	c.(193-195)TCC>TAC	p.S65Y		NM_001004703	NP_001004703	A6NHA9	O4C46_HUMAN	olfactory receptor, family 4, subfamily C,	65	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						GCCTATCTCTCCTTTATTGAT	0.473			NA											14	299					1.02788e-11	1.60271e-11	0.00499	1	0
OR4C16	219428	broad.mit.edu	37	11	55340043	55340043	+	Missense_Mutation	SNP	G	G	T			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr11:55340043G>T	uc010rih.1	+	1	440	c.440G>T	c.(439-441)TGG>TTG	p.W147L		NM_001004701	NP_001004701	Q8NGL9	OR4CG_HUMAN	olfactory receptor, family 4, subfamily C,	147	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2		all_epithelial(135;0.0748)				GCTGTGGCCTGGGTGGGATCC	0.498			NA											51	178					2.43468e-25	4.16323e-25	0.00361	1	0
OR5J2	282775	broad.mit.edu	37	11	55944982	55944982	+	Missense_Mutation	SNP	G	G	T			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr11:55944982G>T	uc010rjb.1	+	1	889	c.889G>T	c.(889-891)GTA>TTA	p.V297L		NM_001005492	NP_001005492	Q8NH18	OR5J2_HUMAN	olfactory receptor, family 5, subfamily J,	297	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|large_intestine(1)|breast(1)|pancreas(1)	4	Esophageal squamous(21;0.00693)					AAACAAGGACGTAAAGGAGGC	0.383			NA											10	34					3.86212e-05	4.81489e-05	0.008291	1	0
CTNND1	1500	broad.mit.edu	37	11	57564429	57564429	+	Silent	SNP	G	G	T			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr11:57564429G>T	uc001nmc.3	+	6	1492	c.921G>T	c.(919-921)CGG>CGT	p.R307R	CTNND1_uc001nlf.1_Silent_p.R307R|CTNND1_uc001nlh.1_Silent_p.R307R|CTNND1_uc001nlu.3_Silent_p.R206R|CTNND1_uc001nlt.3_Silent_p.R206R|CTNND1_uc001nls.3_Silent_p.R206R|CTNND1_uc001nlw.3_Silent_p.R206R|CTNND1_uc001nmf.3_Silent_p.R307R|CTNND1_uc001nmd.3_Silent_p.R253R|CTNND1_uc001nlk.3_Silent_p.R253R|CTNND1_uc001nme.3_Silent_p.R307R|CTNND1_uc001nll.3_Silent_p.R253R|CTNND1_uc001nmg.3_Silent_p.R253R|CTNND1_uc001nlj.3_Silent_p.R253R|CTNND1_uc001nlr.3_Silent_p.R253R|CTNND1_uc001nlp.3_Silent_p.R253R|CTNND1_uc001nlx.3_Intron|CTNND1_uc001nlz.3_Intron|CTNND1_uc009ymn.2_Intron|CTNND1_uc001nlm.3_Silent_p.R307R|CTNND1_uc001nly.3_Intron|CTNND1_uc001nmb.3_Intron|CTNND1_uc001nma.3_Intron|CTNND1_uc001nmi.3_Silent_p.R206R|CTNND1_uc001nmh.3_Silent_p.R307R|CTNND1_uc001nlq.3_Silent_p.R206R|CTNND1_uc001nln.3_Silent_p.R307R|CTNND1_uc001nli.3_Silent_p.R307R|CTNND1_uc001nlo.3_Silent_p.R206R|CTNND1_uc001nlv.3_Silent_p.R206R	NM_001085458	NP_001078927	O60716	CTND1_HUMAN	catenin, delta 1 isoform 1ABC	307					adherens junction organization|cell junction assembly|negative regulation of canonical Wnt receptor signaling pathway|regulation of transcription, DNA-dependent|transcription, DNA-dependent|Wnt receptor signaling pathway	cytosol|midbody|nucleus	cadherin binding|protein binding|receptor binding			breast(4)|ovary(1)|kidney(1)	6		all_epithelial(135;0.155)				CTGCCCGTCGGACTGGGACAC	0.532			NA											22	65					2.39556e-15	3.93011e-15	0.00278	1	0
OR5AN1	390195	broad.mit.edu	37	11	59132182	59132182	+	Missense_Mutation	SNP	C	C	A			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr11:59132182C>A	uc010rks.1	+	1	251	c.251C>A	c.(250-252)TCC>TAC	p.S84Y		NM_001004729	NP_001004729	Q8NGI8	O5AN1_HUMAN	olfactory receptor, family 5, subfamily AN,	84	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						AAGATGCTCTCCAACCTCTTA	0.428			NA											39	145					1.49673e-21	2.53638e-21	0.00623	1	0
SPDYC	387778	broad.mit.edu	37	11	64939753	64939753	+	Missense_Mutation	SNP	G	G	A			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr11:64939753G>A	uc010rnz.1	+	4	295	c.295G>A	c.(295-297)GCC>ACC	p.A99T		NM_001008778	NP_001008778	Q5MJ68	SPDYC_HUMAN	speedy C	99	Speedy/Ringo box; Required for CDK- binding (By similarity).				cell cycle	nucleus	protein kinase binding				0						CTTCCAGCGCGCCCACCTGAA	0.602			NA											4	76					0	0	0.000248	0	0
CTSF	8722	broad.mit.edu	37	11	66335003	66335003	+	Missense_Mutation	SNP	A	A	G			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr11:66335003A>G	uc001oip.2	-	3	533	c.443T>C	c.(442-444)ATT>ACT	p.I148T		NM_003793	NP_003784	Q9UBX1	CATF_HUMAN	cathepsin F precursor	148					proteolysis	lysosome	cysteine-type endopeptidase activity				0						CAGAGAAGAAATCATGGCTGA	0.557			NA											12	99					0	0	0.001368	0	0
PRKRIR	5612	broad.mit.edu	37	11	76062549	76062549	+	Missense_Mutation	SNP	G	G	C			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr11:76062549G>C	uc001oxh.1	-	5	1645	c.1645C>G	c.(1645-1647)CAA>GAA	p.Q549E	PRKRIR_uc010rrz.1_Missense_Mutation_p.Q374E	NM_004705	NP_004696	O43422	P52K_HUMAN	protein-kinase, interferon-inducible double	549					negative regulation of cell proliferation|response to stress|signal transduction		DNA binding|metal ion binding|protein dimerization activity			ovary(2)|pancreas(1)	3						AGTTTCATTTGAATATCAAGT	0.403			NA											3	42					0	0	0.000248	0	0
USP35	57558	broad.mit.edu	37	11	77921493	77921493	+	Silent	SNP	C	C	T			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr11:77921493C>T	uc009yva.1	+	10	2838	c.2592C>T	c.(2590-2592)TAC>TAT	p.Y864Y	USP35_uc001oze.2_Silent_p.Y620Y|USP35_uc001ozc.2_Silent_p.Y432Y|USP35_uc010rsp.1_Silent_p.Y296Y|USP35_uc001ozd.2_Silent_p.Y475Y|USP35_uc001ozf.2_Silent_p.Y595Y	NM_020798	NP_065849	Q9P2H5	UBP35_HUMAN	ubiquitin specific protease 35	864					ubiquitin-dependent protein catabolic process		binding|cysteine-type peptidase activity|ubiquitin thiolesterase activity			lung(2)|ovary(1)	3	all_cancers(14;3.77e-18)|all_epithelial(13;6.16e-21)|Breast(9;5.6e-16)|Ovarian(111;0.152)		OV - Ovarian serous cystadenocarcinoma(8;1.04e-25)			GTCACTACTACTGCTATGCCC	0.632			NA											8	131					0	0	0.004482	0	0
ODZ4	26011	broad.mit.edu	37	11	78381548	78381548	+	Missense_Mutation	SNP	C	C	T			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr11:78381548C>T	uc001ozl.3	-	32	6305	c.5842G>A	c.(5842-5844)GAC>AAC	p.D1948N	ODZ4_uc001ozk.3_Missense_Mutation_p.D173N|ODZ4_uc009yvb.1_Missense_Mutation_p.D532N	NM_001098816	NP_001092286	Q6N022	TEN4_HUMAN	odz, odd Oz/ten-m homolog 4	1948	YD 7.|Extracellular (Potential).				signal transduction	integral to membrane				ovary(2)|pancreas(2)	4						TCATTCTTGTCGAACTCAAAG	0.537			NA											13	61					0	0	0.001855	0	0
DDI1	414301	broad.mit.edu	37	11	103908282	103908282	+	Silent	SNP	C	C	G			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr11:103908282C>G	uc001phr.2	+	1	975	c.732C>G	c.(730-732)CTC>CTG	p.L244L	PDGFD_uc001php.2_Intron|PDGFD_uc001phq.2_Intron	NM_001001711	NP_001001711	Q8WTU0	DDI1_HUMAN	DDI1, DNA-damage inducible 1, homolog 1	244					proteolysis		aspartic-type endopeptidase activity			large_intestine(3)|upper_aerodigestive_tract(1)|pancreas(1)	5		Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.00648)|Melanoma(852;0.055)|all_neural(303;0.164)		BRCA - Breast invasive adenocarcinoma(274;0.00128)|Epithelial(105;0.0631)|all cancers(92;0.169)		TGACGATGCTCTACATTAACT	0.468			NA											27	131					0	0	0.008361	0	0
APOC3	345	broad.mit.edu	37	11	116701581	116701581	+	Missense_Mutation	SNP	G	G	C			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr11:116701581G>C	uc001ppt.1	+	3	194	c.148G>C	c.(148-150)GTG>CTG	p.V50L		NM_000040	NP_000031	P02656	APOC3_HUMAN	apolipoprotein C-III precursor	50					Cdc42 protein signal transduction|cholesterol efflux|cholesterol homeostasis|chylomicron remnant clearance|G-protein coupled receptor protein signaling pathway|high-density lipoprotein particle remodeling|lipoprotein metabolic process|negative regulation of cholesterol import|negative regulation of fatty acid biosynthetic process|negative regulation of high-density lipoprotein particle clearance|negative regulation of lipoprotein lipase activity|negative regulation of low-density lipoprotein particle clearance|negative regulation of receptor-mediated endocytosis|negative regulation of triglyceride catabolic process|negative regulation of very-low-density lipoprotein particle clearance|negative regulation of very-low-density lipoprotein particle remodeling|phospholipid efflux|triglyceride catabolic process|triglyceride homeostasis|very-low-density lipoprotein particle assembly	chylomicron|intermediate-density lipoprotein particle|spherical high-density lipoprotein particle|very-low-density lipoprotein particle	high-density lipoprotein particle receptor binding|lipase inhibitor activity|phospholipid binding				0	all_hematologic(175;0.0487)	Breast(348;0.0126)|Medulloblastoma(222;0.0425)|all_hematologic(192;0.0564)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;8.54e-06)|Epithelial(105;1.62e-05)|all cancers(92;0.000165)|OV - Ovarian serous cystadenocarcinoma(223;0.148)		ACTGAGCAGCGTGCAGGAGTC	0.657	GBM(81;259 1650 7161 35190)		NA											4	40					0	0	0.000248	0	0
CEP164	22897	broad.mit.edu	37	11	117279605	117279605	+	Splice_Site	SNP	G	G	T			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr11:117279605G>T	uc001prc.2	+	29	3757	c.3610_splice	c.e29-1	p.A1204_splice	CEP164_uc001prb.2_Splice_Site_p.A1207_splice|CEP164_uc001prf.2_Intron|CEP164_uc009yzp.1_Splice_Site|CEP164_uc001prg.1_Splice_Site_p.A637_splice	NM_014956	NP_055771	Q9UPV0	CE164_HUMAN	centrosomal protein 164kDa						cell division|DNA repair|G2/M transition of mitotic cell cycle|mitosis	centriole|cytosol|nucleus				ovary(1)|central_nervous_system(1)	2	all_hematologic(175;0.0487)	Breast(348;0.00908)|Medulloblastoma(222;0.0425)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;4e-05)|Epithelial(105;0.0008)		TTACCCCACAGGCCTCAGATG	0.527			NA											6	34					2.7689e-08	3.92781e-08	0.001984	1	0
OR10S1	219873	broad.mit.edu	37	11	123847504	123847504	+	Missense_Mutation	SNP	G	G	C			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr11:123847504G>C	uc001pzm.1	-	1	895	c.895C>G	c.(895-897)CCA>GCA	p.P299A		NM_001004474	NP_001004474	Q8NGN2	O10S1_HUMAN	olfactory receptor, family 10, subfamily S,	299	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0399)		TAAATGAATGGGTTGAGCATT	0.547			NA											13	83					0	0	0.001368	0	0
NCAPD3	23310	broad.mit.edu	37	11	134063940	134063941	+	Missense_Mutation	DNP	CC	CC	GA			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr11:134063940_134063941CC>GA	uc001qhd.1	-	15	2400_2401	c.1794_1795GG>TC	c.(1792-1797)CAGGCC>CATCCC	p.598_599QA>HP	NCAPD3_uc010scm.1_RNA|NCAPD3_uc009zda.1_RNA	NM_015261	NP_056076	P42695	CNDD3_HUMAN	non-SMC condensin II complex, subunit D3	598_599	HEAT 3.				cell division|mitotic chromosome condensation	nuclear centromeric heterochromatin|nuclear condensin complex	methylated histone residue binding			ovary(2)|upper_aerodigestive_tract(1)|lung(1)|kidney(1)	5	all_hematologic(175;0.127)	all_cancers(12;1.68e-21)|all_epithelial(12;5.86e-16)|all_lung(97;1.19e-05)|Lung NSC(97;2.76e-05)|Breast(109;0.000182)|Medulloblastoma(222;0.0245)|all_neural(223;0.0505)|Esophageal squamous(93;0.0559)		Epithelial(10;8.74e-10)|BRCA - Breast invasive adenocarcinoma(10;1e-08)|all cancers(11;1.46e-08)|OV - Ovarian serous cystadenocarcinoma(99;0.00345)|Lung(977;0.227)		GACTGGAGGGCCTGCTTCCGGA	0.441			NA											11	46					0	0	0.004672	0	0
Unknown	0	broad.mit.edu	37	12	92000	92000	+	Missense_Mutation	SNP	A	A	T			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr12:92000A>T	uc010sdi.1	-	2	338	c.310T>A	c.(310-312)TTG>ATG	p.L104M	uc010sdj.1_RNA					SubName: Full=DEAD/H box polypeptide 11 like 11;												NA						GGTCCTGGCAACACTCTGGAC	0.572			NA											4	7					0	0	0.000248	0	0
KCNA5	3741	broad.mit.edu	37	12	5153913	5153913	+	Missense_Mutation	SNP	A	A	G			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr12:5153913A>G	uc001qni.2	+	1	829	c.600A>G	c.(598-600)ATA>ATG	p.I200M		NM_002234	NP_002225	P22460	KCNA5_HUMAN	potassium voltage-gated channel, shaker-related	200						Golgi apparatus|voltage-gated potassium channel complex	delayed rectifier potassium channel activity			ovary(2)|breast(2)	4						CGGACGAGATACGCTTCTACC	0.637			NA											4	46					0	0	0.000248	0	0
VWF	7450	broad.mit.edu	37	12	6120900	6120901	+	Missense_Mutation	DNP	GG	GG	TT			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr12:6120900_6120901GG>TT	uc001qnn.1	-	34	5974_5975	c.5724_5725CC>AA	c.(5722-5727)GGCCAG>GGAAAG	p.Q1909K	VWF_uc010set.1_Intron	NM_000552	NP_000543	P04275	VWF_HUMAN	von Willebrand factor preproprotein	1909					blood coagulation, intrinsic pathway|cell-substrate adhesion|platelet activation|platelet degranulation|protein homooligomerization	endoplasmic reticulum|platelet alpha granule lumen|proteinaceous extracellular matrix|Weibel-Palade body	chaperone binding|collagen binding|glycoprotein binding|immunoglobulin binding|integrin binding|protease binding|protein homodimerization activity|protein N-terminus binding			skin(4)|ovary(3)|pancreas(2)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|breast(1)	12					Antihemophilic Factor(DB00025)	AGCAAGGTCTGGCCATCTGGCT	0.579			NA											4	52					0	0	0.004672	0	0
CD163L1	283316	broad.mit.edu	37	12	7528081	7528081	+	Missense_Mutation	SNP	C	C	T			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr12:7528081C>T	uc001qsy.2	-	11	2823	c.2797G>A	c.(2797-2799)GAT>AAT	p.D933N	CD163L1_uc010sge.1_Missense_Mutation_p.D943N	NM_174941	NP_777601	Q9NR16	C163B_HUMAN	scavenger receptor cysteine-rich type 1	933	SRCR 9.|Extracellular (Potential).					extracellular region|integral to membrane|plasma membrane	scavenger receptor activity			ovary(8)|skin(2)|central_nervous_system(1)	11						ACACGGGCATCTTCTGGGTCC	0.532			NA											8	39					0	0	0.004482	0	0
CLEC4E	26253	broad.mit.edu	37	12	8688715	8688715	+	Silent	SNP	C	C	T			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr12:8688715C>T	uc001quo.1	-	5	624	c.459G>A	c.(457-459)GTG>GTA	p.V153V		NM_014358	NP_055173	Q9ULY5	CLC4E_HUMAN	C-type lectin domain family 4, member E	153	C-type lectin.|Extracellular (Potential).					integral to membrane	sugar binding			central_nervous_system(1)	1	Lung SC(5;0.184)					GTGTGCCGTCCACCCATTGCC	0.433			NA											8	67					0	0	0.004482	0	0
PHC1	1911	broad.mit.edu	37	12	9089500	9089500	+	Missense_Mutation	SNP	A	A	T			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr12:9089500A>T	uc001qvd.2	+	12	2573	c.2417A>T	c.(2416-2418)TAC>TTC	p.Y806F	PHC1_uc001qve.2_Missense_Mutation_p.Y806F	NM_004426	NP_004417	P78364	PHC1_HUMAN	polyhomeotic 1-like	806	FCS-type.				multicellular organismal development	PcG protein complex	DNA binding|zinc ion binding			ovary(1)|breast(1)	2						TGTGGGAAGTACGCCCCCGCA	0.527			NA											4	33					0	0	0.000248	0	0
GRIN2B	2904	broad.mit.edu	37	12	13720066	13720066	+	Missense_Mutation	SNP	G	G	T			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr12:13720066G>T	uc001rbt.2	-	12	2670	c.2491C>A	c.(2491-2493)CTC>ATC	p.L831I		NM_000834	NP_000825	Q13224	NMDE2_HUMAN	N-methyl-D-aspartate receptor subunit 2B	831	Helical; (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	glycine binding|N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			central_nervous_system(4)|ovary(3)|skin(3)|lung(2)	12					Felbamate(DB00949)|Haloperidol(DB00502)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	ATGAGGCTGAGAGCCATGGCC	0.512			NA											21	66					1.55795e-14	2.5412e-14	0.001882	1	0
LST-3TM12	338821	broad.mit.edu	37	12	21196363	21196363	+	Missense_Mutation	SNP	C	C	A			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr12:21196363C>A	uc010sin.1	+	6	682	c.682C>A	c.(682-684)CCA>ACA	p.P228T	SLCO1B3_uc010sil.1_Intron|LST-3TM12_uc010sim.1_Missense_Mutation_p.P275T	NM_001009562	NP_001009562	Q71QF0	Q71QF0_HUMAN	liver-specific organic anion transporter 3TM12	228						membrane	transporter activity				0						TTCTTCTATACCATTCTTTTT	0.363			NA											6	114					5.18039e-06	6.7716e-06	0.00308	1	0
CAPRIN2	65981	broad.mit.edu	37	12	30881654	30881655	+	Missense_Mutation	DNP	CC	CC	AA			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr12:30881654_30881655CC>AA	uc001rji.1	-	8	2460_2461	c.1709_1710GG>TT	c.(1708-1710)TGG>TTT	p.W570F	CAPRIN2_uc001rjf.1_Missense_Mutation_p.W367F|CAPRIN2_uc001rjg.1_Missense_Mutation_p.W237F|CAPRIN2_uc001rjh.1_Missense_Mutation_p.W570F|CAPRIN2_uc001rjj.1_Missense_Mutation_p.W237F|CAPRIN2_uc001rjk.3_Missense_Mutation_p.W570F|CAPRIN2_uc001rjl.3_Missense_Mutation_p.W570F|CAPRIN2_uc001rjm.1_Missense_Mutation_p.W237F|CAPRIN2_uc001rjn.1_Missense_Mutation_p.W237F	NM_001002259	NP_001002259	Q6IMN6	CAPR2_HUMAN	C1q domain containing 1 isoform 1	570					negative regulation of cell growth|negative regulation of translation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of dendrite morphogenesis|positive regulation of dendritic spine morphogenesis|positive regulation of peptidyl-serine phosphorylation|positive regulation of protein binding|positive regulation of transcription from RNA polymerase II promoter	mitochondrion|receptor complex	receptor binding|RNA binding			ovary(1)|central_nervous_system(1)	2	all_lung(12;1.13e-09)|Lung NSC(12;7.98e-08)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0355)|Lung SC(12;0.0905)|Esophageal squamous(101;0.233)					TAGCTACTCCCCAGGACTTTGG	0.441			NA											13	85					0	0	0.004672	0	0
C12orf40	283461	broad.mit.edu	37	12	40114727	40114727	+	Missense_Mutation	SNP	G	G	A			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr12:40114727G>A	uc001rmc.2	+	13	1800	c.1633G>A	c.(1633-1635)GAC>AAC	p.D545N	C12orf40_uc009zjv.1_Intron	NM_001031748	NP_001026918	Q86WS4	CL040_HUMAN	hypothetical protein LOC283461	545										ovary(6)	6						TAAAAACGATGACAAAATTCA	0.338			NA											8	92					0	0	0.00308	0	0
LRRK2	120892	broad.mit.edu	37	12	40707882	40707882	+	Missense_Mutation	SNP	G	G	A			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr12:40707882G>A	uc001rmg.3	+	32	4766	c.4645G>A	c.(4645-4647)GAC>AAC	p.D1549N	LRRK2_uc009zjw.2_Missense_Mutation_p.D387N|LRRK2_uc001rmi.2_Missense_Mutation_p.D382N	NM_198578	NP_940980	Q5S007	LRRK2_HUMAN	leucine-rich repeat kinase 2	1549					activation of MAPKK activity|determination of adult lifespan|exploration behavior|intracellular distribution of mitochondria|negative regulation of branching morphogenesis of a nerve|negative regulation of dendritic spine morphogenesis|negative regulation of neuroblast proliferation|negative regulation of neuron maturation|neuromuscular junction development|neuron death|peptidyl-serine phosphorylation|positive regulation of autophagy|positive regulation of dopamine receptor signaling pathway|positive regulation of programmed cell death|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|positive regulation of protein ubiquitination|protein autophosphorylation|regulation of kidney size|regulation of locomotion|regulation of membrane potential|response to oxidative stress|small GTPase mediated signal transduction|tangential migration from the subventricular zone to the olfactory bulb	external side of mitochondrial outer membrane	ATP binding|GTP binding|GTP-dependent protein kinase activity|GTPase activator activity|MAP kinase kinase activity|protein homodimerization activity|tubulin binding			ovary(12)|stomach(5)|upper_aerodigestive_tract(2)|lung(2)|large_intestine(1)|urinary_tract(1)|pancreas(1)	24	all_cancers(12;0.00108)|Breast(8;0.218)	Lung NSC(34;0.0942)|all_lung(34;0.11)				TCCCGTAATTGACCGGAAACG	0.383			NA											6	60					0	0	0.001168	0	0
OR8S1	341568	broad.mit.edu	37	12	48919525	48919525	+	Silent	SNP	G	G	T			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr12:48919525G>T	uc010slu.1	+	1	111	c.111G>T	c.(109-111)CTG>CTT	p.L37L		NM_001005203	NP_001005203	Q8NH09	OR8S1_HUMAN	olfactory receptor, family 8, subfamily S,	37	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						TTTACCTCCTGACCATAATGG	0.512			NA											20	196					0.000175454	0.000212195	0.001523	1	0
LIMA1	51474	broad.mit.edu	37	12	50589612	50589612	+	Splice_Site	SNP	C	C	T			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr12:50589612C>T	uc001rwj.3	-	8	1204	c.1030_splice	c.e8+1	p.R344_splice	LIMA1_uc001rwg.3_Splice_Site_p.R42_splice|LIMA1_uc001rwh.3_Splice_Site_p.R184_splice|LIMA1_uc001rwi.3_Splice_Site_p.P184_splice|LIMA1_uc001rwk.3_Splice_Site_p.P344_splice|LIMA1_uc010smr.1_Splice_Site|LIMA1_uc010sms.1_Splice_Site	NM_016357	NP_057441	Q9UHB6	LIMA1_HUMAN	LIM domain and actin binding 1 isoform b						actin filament bundle assembly|negative regulation of actin filament depolymerization|ruffle organization	cytoplasm|focal adhesion|stress fiber	actin filament binding|actin monomer binding|zinc ion binding			ovary(1)	1						AGAATGCTTACGGGAGTCATC	0.398			NA											7	101					0	0	0.00308	0	0
OR9K2	441639	broad.mit.edu	37	12	55523851	55523851	+	Missense_Mutation	SNP	C	C	G			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr12:55523851C>G	uc010spe.1	+	1	299	c.299C>G	c.(298-300)TCT>TGT	p.S100C		NM_001005243	NP_001005243	Q8NGE7	OR9K2_HUMAN	olfactory receptor, family 9, subfamily K,	100	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|pancreas(1)	2						TTCTATTCATCTGTTATTGAA	0.418			NA											15	205					0	0	0.00245	0	0
KIF5A	3798	broad.mit.edu	37	12	57974797	57974797	+	Missense_Mutation	SNP	G	G	T			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr12:57974797G>T	uc001sor.1	+	24	2805	c.2597G>T	c.(2596-2598)AGG>ATG	p.R866M	KIF5A_uc010srr.1_Missense_Mutation_p.R777M	NM_004984	NP_004975	Q12840	KIF5A_HUMAN	kinesin family member 5A	866					blood coagulation|cell death|microtubule-based movement|synaptic transmission	cytosol|kinesin complex|membrane fraction|microtubule|perinuclear region of cytoplasm	ATP binding|microtubule motor activity			ovary(2)|skin(1)	3						AAACGACTTAGGGCTACGGCT	0.562			NA											9	47					0.000442599	0.000528505	0.006214	1	0
KCNC2	3747	broad.mit.edu	37	12	75444222	75444222	+	Missense_Mutation	SNP	C	C	G			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr12:75444222C>G	uc001sxg.1	-	3	2107	c.1563G>C	c.(1561-1563)CAG>CAC	p.Q521H	KCNC2_uc009zry.2_Missense_Mutation_p.Q521H|KCNC2_uc001sxe.2_Missense_Mutation_p.Q521H|KCNC2_uc001sxf.2_Missense_Mutation_p.Q521H|KCNC2_uc010stw.1_Missense_Mutation_p.Q521H	NM_139137	NP_631875	Q96PR1	KCNC2_HUMAN	Shaw-related voltage-gated potassium channel	521	Cytoplasmic (Potential).				energy reserve metabolic process|regulation of insulin secretion	voltage-gated potassium channel complex	voltage-gated potassium channel activity			breast(2)|pancreas(2)|skin(1)|lung(1)	6						ATGTGTCACTCTGTGTACTAT	0.413			NA											12	133					0	0	0.00245	0	0
KCNC2	3747	broad.mit.edu	37	12	75444888	75444888	+	Silent	SNP	G	G	A			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr12:75444888G>A	uc001sxg.1	-	3	1441	c.897C>T	c.(895-897)GTC>GTT	p.V299V	KCNC2_uc009zry.2_Silent_p.V299V|KCNC2_uc001sxe.2_Silent_p.V299V|KCNC2_uc001sxf.2_Silent_p.V299V|KCNC2_uc010stw.1_Silent_p.V299V	NM_139137	NP_631875	Q96PR1	KCNC2_HUMAN	Shaw-related voltage-gated potassium channel	299	Helical; Name=Segment S2; (Potential).				energy reserve metabolic process|regulation of insulin secretion	voltage-gated potassium channel complex	voltage-gated potassium channel activity			breast(2)|pancreas(2)|skin(1)|lung(1)	6						AAACAATACGGACTAAAAATT	0.378			NA											10	65					0	0	0.000978	0	0
SLC6A15	55117	broad.mit.edu	37	12	85285712	85285712	+	Missense_Mutation	SNP	G	G	C			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr12:85285712G>C	uc001szv.2	-	2	681	c.188C>G	c.(187-189)GCT>GGT	p.A63G	SLC6A15_uc010sul.1_Intron|SLC6A15_uc001szy.2_Missense_Mutation_p.A63G	NM_182767	NP_877499	Q9H2J7	S6A15_HUMAN	solute carrier family 6, member 15 isoform 1	63	Cytoplasmic (Potential).				cellular nitrogen compound metabolic process|leucine transport|proline transport	integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity			pancreas(2)|ovary(1)	3						ACTGTTCCAAGCTGGTCTTTC	0.418			NA											13	131					0	0	0.001368	0	0
BTBD11	121551	broad.mit.edu	37	12	107937905	107937905	+	Silent	SNP	C	C	A			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr12:107937905C>A	uc001tmk.1	+	3	2000	c.1479C>A	c.(1477-1479)CTC>CTA	p.L493L	BTBD11_uc009zut.1_Silent_p.L493L|BTBD11_uc001tmj.2_Silent_p.L493L	NM_001018072	NP_001018082	A6QL63	BTBDB_HUMAN	BTB (POZ) domain containing 11 isoform a	493						integral to membrane	DNA binding			skin(2)|ovary(1)	3						AAGTCAACCTCCAGGTGGAAA	0.567			NA											5	33					3.59834e-05	4.51587e-05	0.001168	1	0
BTBD11	121551	broad.mit.edu	37	12	108042999	108042999	+	Missense_Mutation	SNP	T	T	A			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr12:108042999T>A	uc001tmk.1	+	15	3460	c.2939T>A	c.(2938-2940)CTC>CAC	p.L980H	BTBD11_uc001tmj.2_Missense_Mutation_p.L980H|BTBD11_uc001tml.1_Missense_Mutation_p.L517H|BTBD11_uc001tmm.1_Missense_Mutation_p.L59H	NM_001018072	NP_001018082	A6QL63	BTBDB_HUMAN	BTB (POZ) domain containing 11 isoform a	980	BTB.					integral to membrane	DNA binding			skin(2)|ovary(1)	3						ATGCAGTATCTCTACTATGGT	0.473			NA											8	90					0	0	0.004482	0	0
SVOP	55530	broad.mit.edu	37	12	109306415	109306415	+	Nonsense_Mutation	SNP	G	G	A			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr12:109306415G>A	uc010sxh.1	-	15	1715	c.1543C>T	c.(1543-1545)CGA>TGA	p.R515*		NM_018711	NP_061181	Q8N4V2	SVOP_HUMAN	SV2 related protein	515	Cytoplasmic (Potential).					cell junction|integral to membrane|synaptic vesicle membrane	ion transmembrane transporter activity				0						TGCAGTCCTCGGCCTTTGGTC	0.607			NA											8	87					0	0	0.004482	0	0
GPR109A	338442	broad.mit.edu	37	12	123186931	123186931	+	Silent	SNP	G	G	T			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr12:123186931G>T	uc001ucx.1	-	1	974	c.900C>A	c.(898-900)TCC>TCA	p.S300S	GPR81_uc001ucw.1_Intron	NM_177551	NP_808219	Q8TDS4	HCAR2_HUMAN	G protein-coupled receptor 109A	300	Cytoplasmic (Potential).				negative regulation of lipid catabolic process|neutrophil apoptosis|positive regulation of adiponectin secretion|positive regulation of neutrophil apoptosis	integral to membrane|plasma membrane	nicotinic acid receptor activity|purinergic nucleotide receptor activity, G-protein coupled				0	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;2.12e-05)|Epithelial(86;3.19e-05)|BRCA - Breast invasive adenocarcinoma(302;0.196)	Mepenzolate(DB04843)|Niacin(DB00627)	AGTTGGGAAAGGATGGGCTGG	0.542			NA											11	75					0.000673444	0.000794103	0.008291	1	0
AACS	65985	broad.mit.edu	37	12	125613889	125613889	+	Missense_Mutation	SNP	G	G	T			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr12:125613889G>T	uc001uhc.2	+	14	1638	c.1432G>T	c.(1432-1434)GTC>TTC	p.V478F	AACS_uc001uhd.2_Missense_Mutation_p.V478F|AACS_uc009zyh.2_Intron|AACS_uc009zyi.2_Missense_Mutation_p.V76F	NM_023928	NP_076417	Q86V21	AACS_HUMAN	acetoacetyl-CoA synthetase	478					fatty acid metabolic process	cytosol	acetoacetate-CoA ligase activity|ATP binding			ovary(1)|liver(1)|central_nervous_system(1)	3	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;9.82e-05)|Epithelial(86;0.000642)|all cancers(50;0.00843)		AGGAAAGGCGGTCTGGGGAGA	0.507			NA											25	143					5.35047e-06	6.9778e-06	0.00333	1	0
TMEM132D	121256	broad.mit.edu	37	12	129559047	129559047	+	Missense_Mutation	SNP	C	C	A			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr12:129559047C>A	uc009zyl.1	-	9	3001	c.2673G>T	c.(2671-2673)CAG>CAT	p.Q891H	TMEM132D_uc001uia.2_Missense_Mutation_p.Q429H	NM_133448	NP_597705	Q14C87	T132D_HUMAN	transmembrane protein 132D precursor	891	Extracellular (Potential).					integral to membrane		p.Q891*(1)		ovary(10)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	14	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0934)|Breast(359;0.133)		OV - Ovarian serous cystadenocarcinoma(86;0.000288)|Epithelial(86;0.0116)|all cancers(50;0.0246)		GGAGGTCCACCTGGGCTGGGA	0.527			NA											9	62					0.00621372	0.00704802	0.006214	1	0
FZD10	11211	broad.mit.edu	37	12	130648268	130648268	+	Missense_Mutation	SNP	C	C	T			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr12:130648268C>T	uc001uii.2	+	1	1237	c.781C>T	c.(781-783)CGC>TGC	p.R261C	uc001uig.1_5'Flank|uc001uih.1_5'Flank	NM_007197	NP_009128	Q9ULW2	FZD10_HUMAN	frizzled 10 precursor	261	Cytoplasmic (Potential).				brain development|canonical Wnt receptor signaling pathway|cellular response to retinoic acid|embryo development|gonad development|negative regulation of Rho GTPase activity|neuron differentiation|non-canonical Wnt receptor signaling pathway|positive regulation of JUN kinase activity|positive regulation of Rac GTPase activity|regulation of actin cytoskeleton organization|vasculature development	cell projection|cell surface|cytoplasm|integral to plasma membrane	G-protein coupled receptor activity|PDZ domain binding|Wnt receptor activity|Wnt-protein binding			lung(3)|breast(1)|central_nervous_system(1)	5	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.3e-06)|Epithelial(86;1.66e-05)|all cancers(50;5.18e-05)		CTACCCCGAGCGCCCCATCAT	0.657			NA											12	109					0	0	0.001855	0	0
TUBA3C	7278	broad.mit.edu	37	13	19748131	19748131	+	Missense_Mutation	SNP	C	C	A			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr13:19748131C>A	uc009zzj.2	-	5	1274	c.1225G>T	c.(1225-1227)GTG>TTG	p.V409L		NM_006001	NP_005992	Q13748	TBA3C_HUMAN	tubulin, alpha 3c	409					'de novo' posttranslational protein folding|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|protein binding|structural molecule activity			ovary(3)|skin(2)	5		all_cancers(29;1.31e-20)|all_epithelial(30;1.59e-20)|all_lung(29;6.91e-20)|Lung NSC(5;9.25e-17)|Hepatocellular(1;0.0207)|Lung SC(185;0.0262)|Ovarian(182;0.162)		all cancers(112;6.78e-06)|Epithelial(112;3.79e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00172)|Lung(94;0.0186)|LUSC - Lung squamous cell carcinoma(192;0.108)		CCTTCTCCCACGTACCAGTGC	0.607			NA											17	134					0.00400662	0.00459059	0.004007	1	0
CSNK1A1L	122011	broad.mit.edu	37	13	37679325	37679325	+	Missense_Mutation	SNP	G	G	C			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr13:37679325G>C	uc001uwm.1	-	1	477	c.69C>G	c.(67-69)ATC>ATG	p.I23M		NM_145203	NP_660204	Q8N752	KC1AL_HUMAN	casein kinase 1, alpha 1-like	23	ATP (By similarity).|Protein kinase.				Wnt receptor signaling pathway	cytoplasm	ATP binding|protein serine/threonine kinase activity			large_intestine(1)	1		Lung NSC(96;7.97e-05)|Breast(139;0.0615)|Lung SC(185;0.0743)|Prostate(109;0.109)		all cancers(112;3.58e-07)|Epithelial(112;1.29e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00695)|BRCA - Breast invasive adenocarcinoma(63;0.0117)|GBM - Glioblastoma multiforme(144;0.0407)		AGCCAGACCCGATCTTCCGCA	0.557			NA											3	101					0	0	0.000602	0	0
ATP7B	540	broad.mit.edu	37	13	52539088	52539088	+	Missense_Mutation	SNP	C	C	A			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr13:52539088C>A	uc001vfw.2	-	5	1946	c.1789G>T	c.(1789-1791)GTT>TTT	p.V597F	ATP7B_uc010adv.2_Intron|ATP7B_uc001vfx.2_Missense_Mutation_p.V597F|ATP7B_uc001vfy.2_Missense_Mutation_p.V486F|ATP7B_uc010tgt.1_Missense_Mutation_p.V597F|ATP7B_uc010tgu.1_Missense_Mutation_p.V597F|ATP7B_uc010tgv.1_Missense_Mutation_p.V597F|ATP7B_uc010tgw.1_Intron	NM_000053	NP_000044	P35670	ATP7B_HUMAN	ATPase, Cu++ transporting, beta polypeptide	597	HMA 6.|Cytoplasmic (Potential).				ATP biosynthetic process|cellular copper ion homeostasis|copper ion import|response to copper ion|sequestering of calcium ion	Golgi membrane|integral to plasma membrane|late endosome|mitochondrion	ATP binding|copper ion binding|copper-exporting ATPase activity|protein binding			ovary(1)|central_nervous_system(1)|skin(1)	3		Breast(56;0.000207)|Lung NSC(96;0.000845)|Prostate(109;0.0235)|Hepatocellular(98;0.065)|all_neural(104;0.19)		GBM - Glioblastoma multiforme(99;5.25e-08)		GCAAGGGCAACGGAGGCATAA	0.453			NA							Wilson_disease				15	73					4.14922e-12	6.54166e-12	0.004007	1	0
C13orf34	79866	broad.mit.edu	37	13	73320191	73320191	+	Missense_Mutation	SNP	A	A	G			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr13:73320191A>G	uc001viv.1	+	9	967	c.848A>G	c.(847-849)CAG>CGG	p.Q283R	C13orf34_uc010thq.1_Missense_Mutation_p.Q58R|C13orf34_uc010aen.1_Missense_Mutation_p.Q358R|C13orf34_uc010thr.1_Missense_Mutation_p.Q213R|C13orf34_uc001viw.1_Missense_Mutation_p.Q232R	NM_024808	NP_079084	Q6PGQ7	BORA_HUMAN	aurora borealis	283					cell division|mitosis|regulation of mitosis|regulation of mitotic spindle organization|regulation of protein localization		protein kinase binding				0		Breast(118;0.0735)		GBM - Glioblastoma multiforme(99;0.000227)		ATTGAATTTCAGATAGGAGAG	0.348			NA											3	143					0	0	0.000248	0	0
MYCBP2	23077	broad.mit.edu	37	13	77779653	77779653	+	Missense_Mutation	SNP	T	T	G			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr13:77779653T>G	uc001vkf.2	-	26	3647	c.3556A>C	c.(3556-3558)AAG>CAG	p.K1186Q	MYCBP2_uc010aev.2_Missense_Mutation_p.K590Q	NM_015057	NP_055872	O75592	MYCB2_HUMAN	MYC binding protein 2	1186					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ligase activity|protein binding|zinc ion binding			ovary(4)|breast(4)|skin(3)|lung(2)|pancreas(1)	14		Breast(118;0.212)|Acute lymphoblastic leukemia(28;0.22)		GBM - Glioblastoma multiforme(99;0.109)		GAATAAACCTTCATTACTGCT	0.348			NA											5	33					0	0	0.000602	0	0
SLITRK5	26050	broad.mit.edu	37	13	88328487	88328487	+	Nonsense_Mutation	SNP	G	G	T			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr13:88328487G>T	uc001vln.2	+	2	1063	c.844G>T	c.(844-846)GAA>TAA	p.E282*	SLITRK5_uc010tic.1_Nonsense_Mutation_p.E41*	NM_015567	NP_056382	O94991	SLIK5_HUMAN	SLIT and NTRK-like family, member 5 precursor	282	LRRCT 1.|Extracellular (Potential).					integral to membrane				ovary(2)|pancreas(2)|central_nervous_system(1)	5	all_neural(89;0.101)|Medulloblastoma(90;0.163)					ATCCAAGCAGGAACTTTGCCC	0.542			NA											15	108					1.99824e-07	2.75183e-07	0.00499	1	0
RPGRIP1	57096	broad.mit.edu	37	14	21795868	21795868	+	Nonsense_Mutation	SNP	G	G	T			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr14:21795868G>T	uc001wag.2	+	17	2797	c.2797G>T	c.(2797-2799)GAG>TAG	p.E933*	RPGRIP1_uc001wah.2_Nonsense_Mutation_p.E575*|RPGRIP1_uc001wai.2_Nonsense_Mutation_p.E259*|RPGRIP1_uc001wak.2_Nonsense_Mutation_p.E408*|RPGRIP1_uc010aim.2_Nonsense_Mutation_p.E316*|RPGRIP1_uc001wal.2_Nonsense_Mutation_p.E292*|RPGRIP1_uc001wam.2_Nonsense_Mutation_p.E250*	NM_020366	NP_065099	Q96KN7	RPGR1_HUMAN	retinitis pigmentosa GTPase regulator	933					response to stimulus|visual perception	cilium				ovary(4)|breast(2)|pancreas(1)	7	all_cancers(95;0.0017)	all_cancers(140;0.0973)	Epithelial(56;6.24e-07)|all cancers(55;6.56e-06)	GBM - Glioblastoma multiforme(265;0.00888)		CATACCCCCTGAGAGCTTCCT	0.458			NA											6	57					3.59834e-05	4.51587e-05	0.001168	1	0
MYH6	4624	broad.mit.edu	37	14	23876300	23876300	+	Missense_Mutation	SNP	C	C	G			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr14:23876300C>G	uc001wjv.2	-	3	200	c.133G>C	c.(133-135)GAG>CAG	p.E45Q	MYH6_uc010akp.1_Missense_Mutation_p.E45Q	NM_002471	NP_002462	P13533	MYH6_HUMAN	myosin heavy chain 6	45	Myosin head-like.				adult heart development|atrial cardiac muscle tissue morphogenesis|cardiac muscle fiber development|in utero embryonic development|muscle filament sliding|regulation of ATPase activity|regulation of blood pressure|regulation of heart rate|regulation of the force of heart contraction|sarcomere organization|striated muscle contraction|ventricular cardiac muscle tissue morphogenesis|visceral muscle development	cytosol|focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|protein kinase binding|structural constituent of muscle			pancreas(2)|ovary(1)|skin(1)	4	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00764)|READ - Rectum adenocarcinoma(4;0.0289)|Colorectal(4;0.0441)		TTGACAAACTCTTCCTTGTCA	0.582			NA											6	457					0	0	0.001168	0	0
RNF31	55072	broad.mit.edu	37	14	24618772	24618772	+	Missense_Mutation	SNP	G	G	C			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr14:24618772G>C	uc001wmn.1	+	6	1038	c.789G>C	c.(787-789)CAG>CAC	p.Q263H	PSME2_uc001wmj.2_5'Flank|PSME2_uc001wmk.2_5'Flank|RNF31_uc001wml.1_Missense_Mutation_p.Q112H|RNF31_uc001wmm.1_Intron|RNF31_uc010alg.1_Missense_Mutation_p.Q78H|RNF31_uc001wmo.1_5'Flank|RNF31_uc001wmp.2_5'Flank	NM_017999	NP_060469	Q96EP0	RNF31_HUMAN	ring finger protein 31	263	Polyubiquitin-binding.				CD40 signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|protein linear polyubiquitination|T cell receptor signaling pathway	CD40 receptor complex|internal side of plasma membrane|LUBAC complex	ubiquitin binding|ubiquitin-protein ligase activity|zinc ion binding			large_intestine(1)|ovary(1)	2				GBM - Glioblastoma multiforme(265;0.00861)		GGGTCCTGCAGGGTACCCACC	0.557			NA											19	59					0	0	0.00278	0	0
GZMB	3002	broad.mit.edu	37	14	25103412	25103412	+	Translation_Start_Site	SNP	T	T	A			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr14:25103412T>A	uc001wps.2	-	1	21	c.-45A>T	c.(-47--43)CAAGG>CATGG		GZMB_uc010ama.2_Translation_Start_Site|GZMB_uc010amb.2_RNA	NM_004131	NP_004122	P10144	GRAB_HUMAN	granzyme B precursor						activation of pro-apoptotic gene products|cleavage of lamin|cytolysis|induction of apoptosis by intracellular signals	cytosol|immunological synapse|nucleus	protein binding|serine-type endopeptidase activity				0				GBM - Glioblastoma multiforme(265;0.028)		TGTTTCCTCCTTGCTCTCTTT	0.527			NA											4	7					0	0	0.000248	0	0
FANCM	57697	broad.mit.edu	37	14	45669130	45669130	+	Missense_Mutation	SNP	C	C	G			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr14:45669130C>G	uc001wwd.3	+	23	6165	c.6066C>G	c.(6064-6066)ATC>ATG	p.I2022M	FANCM_uc010anf.2_Missense_Mutation_p.I1996M|FANCM_uc001wwe.3_Missense_Mutation_p.I1558M|FANCM_uc010ang.2_Missense_Mutation_p.I1271M	NM_020937	NP_065988	Q8IYD8	FANCM_HUMAN	Fanconi anemia, complementation group M	2022	Interaction with FAAP24 and EME1.				DNA repair	Fanconi anaemia nuclear complex	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding|nuclease activity|protein binding			ovary(3)|lung(2)|breast(2)	7						CTGAGGAGATCTATAGATATA	0.338			NA						Involved_in_tolerance_or_repair_of_DNA_crosslinks	FanconAnemia				8	128					0	0	0.00308	0	0
ZFYVE26	23503	broad.mit.edu	37	14	68256100	68256100	+	Missense_Mutation	SNP	G	G	C			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr14:68256100G>C	uc001xka.2	-	16	3110	c.2971C>G	c.(2971-2973)CTT>GTT	p.L991V	ZFYVE26_uc010tsz.1_RNA|ZFYVE26_uc001xkc.3_Missense_Mutation_p.L991V	NM_015346	NP_056161	Q68DK2	ZFY26_HUMAN	zinc finger, FYVE domain containing 26	991					cell cycle|cell death|cytokinesis|double-strand break repair via homologous recombination	centrosome|midbody	metal ion binding|phosphatidylinositol-3-phosphate binding|protein binding			ovary(9)|breast(2)	11				all cancers(60;0.000763)|OV - Ovarian serous cystadenocarcinoma(108;0.0011)|BRCA - Breast invasive adenocarcinoma(234;0.0115)		GTCTCCAAAAGCTGCTTGCAG	0.527			NA											7	90					0	0	0.001984	0	0
C14orf159	80017	broad.mit.edu	37	14	91626659	91626659	+	Silent	SNP	G	G	T			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr14:91626659G>T	uc001xzb.2	+	5	789	c.21G>T	c.(19-21)CTG>CTT	p.L7L	C14orf159_uc010atu.1_Silent_p.L7L|C14orf159_uc010atv.1_RNA|C14orf159_uc001xyy.2_Silent_p.L7L|C14orf159_uc001xyx.2_Silent_p.L7L|C14orf159_uc001xyw.2_Silent_p.L7L|C14orf159_uc001xzc.2_Silent_p.L7L|C14orf159_uc001xza.2_Silent_p.L7L|C14orf159_uc001xyv.2_Silent_p.L7L|C14orf159_uc001xyz.2_5'UTR|C14orf159_uc010twj.1_Silent_p.L7L|C14orf159_uc001xze.2_Silent_p.L7L	NM_001102366	NP_001095836	Q7Z3D6	CN159_HUMAN	hypothetical protein LOC80017 isoform a	7						mitochondrion				central_nervous_system(2)|ovary(1)	3		all_cancers(154;0.0191)|all_epithelial(191;0.241)		Epithelial(152;0.141)|OV - Ovarian serous cystadenocarcinoma(161;0.207)		CACTCCACCTGAGGTCCCGCC	0.483			NA											20	70					3.7963e-18	6.33837e-18	0.00333	1	0
TNFAIP2	7127	broad.mit.edu	37	14	103596402	103596402	+	Missense_Mutation	SNP	G	G	T			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr14:103596402G>T	uc001ymm.1	+	4	1170	c.1039G>T	c.(1039-1041)GTG>TTG	p.V347L	TNFAIP2_uc010awo.1_Missense_Mutation_p.V59L|TNFAIP2_uc010txz.1_Missense_Mutation_p.V16L|TNFAIP2_uc010tya.1_5'Flank	NM_006291	NP_006282	Q03169	TNAP2_HUMAN	tumor necrosis factor, alpha-induced protein 2	347					angiogenesis|cell differentiation	extracellular space				central_nervous_system(1)	1		Melanoma(154;0.155)	Epithelial(46;0.191)			GGCTGAGGATGTGCCTCCCCA	0.652			NA											12	17					1.61879e-10	2.4368e-10	0.001368	1	0
TNFAIP2	7127	broad.mit.edu	37	14	103596404	103596404	+	Silent	SNP	G	G	T			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr14:103596404G>T	uc001ymm.1	+	4	1172	c.1041G>T	c.(1039-1041)GTG>GTT	p.V347V	TNFAIP2_uc010awo.1_Silent_p.V59V|TNFAIP2_uc010txz.1_Silent_p.V16V|TNFAIP2_uc010tya.1_5'Flank	NM_006291	NP_006282	Q03169	TNAP2_HUMAN	tumor necrosis factor, alpha-induced protein 2	347					angiogenesis|cell differentiation	extracellular space				central_nervous_system(1)	1		Melanoma(154;0.155)	Epithelial(46;0.191)			CTGAGGATGTGCCTCCCCAGA	0.647			NA											10	17					1.33987e-11	2.08342e-11	0.008291	1	0
HERC2	8924	broad.mit.edu	37	15	28491134	28491134	+	Missense_Mutation	SNP	G	G	C			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr15:28491134G>C	uc001zbj.2	-	23	3576	c.3470C>G	c.(3469-3471)GCT>GGT	p.A1157G		NM_004667	NP_004658	O95714	HERC2_HUMAN	hect domain and RLD 2	1157					DNA repair|intracellular protein transport|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	guanyl-nucleotide exchange factor activity|heme binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(4)|lung(4)|skin(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	13		all_lung(180;1.3e-11)|Breast(32;0.000194)|Colorectal(260;0.227)		all cancers(64;3.93e-09)|Epithelial(43;9.99e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0271)|GBM - Glioblastoma multiforme(186;0.0497)|Lung(196;0.199)		CAGAGGTACAGCTCCAGCCTC	0.473			NA											10	71					0	0	0.006214	0	0
TMEM85	51234	broad.mit.edu	37	15	34519984	34519984	+	Missense_Mutation	SNP	C	C	G	rs11544437		TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr15:34519984C>G	uc001zhq.2	+	3	363	c.292C>G	c.(292-294)CCT>GCT	p.P98A	TMEM85_uc001zhr.2_RNA|TMEM85_uc001zhs.2_Missense_Mutation_p.P98A|TMEM85_uc010bat.2_Intron	NM_016454	NP_057538	Q5J8M3	TMM85_HUMAN	transmembrane protein 85	98	Helical; (Potential).				apoptosis	integral to membrane					0		all_lung(180;1.15e-06)		all cancers(64;1.03e-17)|GBM - Glioblastoma multiforme(113;3.33e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0244)|Lung(196;0.217)		CTCCATCTTCCCTACTATGAT	0.453			NA											5	101					0	0	0.000602	0	0
BAHD1	22893	broad.mit.edu	37	15	40757633	40757633	+	Missense_Mutation	SNP	A	A	T			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr15:40757633A>T	uc001zlu.2	+	6	2223	c.2152A>T	c.(2152-2154)AGG>TGG	p.R718W	BAHD1_uc001zlt.2_Missense_Mutation_p.R717W|BAHD1_uc010bbp.1_Missense_Mutation_p.R714W|BAHD1_uc001zlv.2_Missense_Mutation_p.R715W	NM_014952	NP_055767	Q8TBE0	BAHD1_HUMAN	bromo adjacent homology domain containing 1	718	BAH.				heterochromatin formation|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromatin silencing complex|chromosome	chromatin binding|DNA binding|protein binding				0		all_cancers(109;8.28e-19)|all_epithelial(112;2.64e-15)|Lung NSC(122;5.14e-11)|all_lung(180;1.27e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;3.46e-06)|BRCA - Breast invasive adenocarcinoma(123;0.08)		CGAGTACTGCAGGTAGGTGGT	0.557			NA											8	35					0	0	0.004482	0	0
FBN1	2200	broad.mit.edu	37	15	48755419	48755419	+	Missense_Mutation	SNP	C	C	A			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr15:48755419C>A	uc001zwx.1	-	42	5412	c.5084G>T	c.(5083-5085)TGC>TTC	p.C1695F	FBN1_uc010beo.1_RNA	NM_000138	NP_000129	P35555	FBN1_HUMAN	fibrillin 1 precursor	1695	TB 7.		Missing (in ADWMS).		heart development|negative regulation of BMP signaling pathway by extracellular sequestering of BMP|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|skeletal system development	basement membrane|extracellular space|microfibril	calcium ion binding|extracellular matrix structural constituent|protein binding			ovary(2)|large_intestine(1)	3		all_lung(180;0.00279)		all cancers(107;4.24e-07)|GBM - Glioblastoma multiforme(94;1.41e-05)		GTTTCTGTAGCACAAACTTCT	0.423			NA											19	88					1.36565e-18	2.30046e-18	0.00278	1	0
LIPC	3990	broad.mit.edu	37	15	58834830	58834830	+	Missense_Mutation	SNP	A	A	T			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr15:58834830A>T	uc010bga.1	+	6	1162	c.554A>T	c.(553-555)CAC>CTC	p.H185L	LIPC_uc010bfz.1_Missense_Mutation_p.H185L|LIPC_uc002afa.1_Missense_Mutation_p.H185L|LIPC_uc010bgb.1_Missense_Mutation_p.H83L|LIPC_uc010ugy.1_Missense_Mutation_p.H124L	NM_000236	NP_000227	P11150	LIPC_HUMAN	lipase C precursor	185	Heparin-binding (Potential).				cholesterol homeostasis|chylomicron remnant clearance|fatty acid biosynthetic process|high-density lipoprotein particle remodeling|intermediate-density lipoprotein particle remodeling|low-density lipoprotein particle remodeling|phosphatidylcholine catabolic process|triglyceride catabolic process|triglyceride homeostasis|very-low-density lipoprotein particle remodeling	high-density lipoprotein particle	apolipoprotein binding|heparin binding|low-density lipoprotein particle binding|phospholipase activity|triglyceride lipase activity			ovary(1)	1		Colorectal(260;0.215)		GBM - Glioblastoma multiforme(80;0.00213)|all cancers(107;0.00548)		GGTGGAACGCACAAGATTGGG	0.512			NA											7	73					0	0	0.004482	0	0
PARP16	54956	broad.mit.edu	37	15	65553264	65553264	+	Silent	SNP	T	T	A			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr15:65553264T>A	uc002aoo.2	-	5	1046	c.792A>T	c.(790-792)CGA>CGT	p.R264R	PARP16_uc002aop.2_Silent_p.R149R|PARP16_uc002aoq.2_Silent_p.R264R	NM_017851	NP_060321	Q8N5Y8	PAR16_HUMAN	poly (ADP-ribose) polymerase family, member 16	264	PARP catalytic.					integral to membrane	NAD+ ADP-ribosyltransferase activity			lung(2)	2						GGTACTTCACTCGCAGCAGCT	0.483	NSCLC(50;885 1163 13509 21242 41978)		NA											24	129					0	0	0.00333	0	0
CSPG4	1464	broad.mit.edu	37	15	75983101	75983101	+	Missense_Mutation	SNP	G	G	A			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr15:75983101G>A	uc002baw.2	-	3	398	c.305C>T	c.(304-306)ACG>ATG	p.T102M		NM_001897	NP_001888	Q6UVK1	CSPG4_HUMAN	chondroitin sulfate proteoglycan 4 precursor	102	Extracellular (Potential).|Globular or compact configuration stabilized by disulfide bonds.|Laminin G-like 1.|Neurite growth inhibition (By similarity).				angiogenesis|cell differentiation|intracellular signal transduction|positive regulation of peptidyl-tyrosine phosphorylation|tissue remodeling	apical plasma membrane|cell surface|integral to plasma membrane|intracellular|lamellipodium membrane	protein kinase binding|signal transducer activity			ovary(2)|pancreas(1)	3						ACTCAGCAGCGTCTCTGCTGG	0.582			NA											6	79					0	0	0.00308	0	0
CPEB1	64506	broad.mit.edu	37	15	83221230	83221230	+	Missense_Mutation	SNP	C	C	G			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr15:83221230C>G	uc002bit.2	-	8	1532	c.1395G>C	c.(1393-1395)GAG>GAC	p.E465D	CPEB1_uc002biq.2_Missense_Mutation_p.E325D|CPEB1_uc002bir.2_Missense_Mutation_p.E330D|CPEB1_uc002bis.2_Missense_Mutation_p.E325D|CPEB1_uc010uod.1_Missense_Mutation_p.E174D|CPEB1_uc010uoe.1_Missense_Mutation_p.E403D|CPEB1_uc002biu.2_Missense_Mutation_p.E427D|CPEB1_uc010uof.1_Missense_Mutation_p.E325D|CPEB1_uc002biv.2_Missense_Mutation_p.E400D|CPEB1_uc002bip.2_Missense_Mutation_p.E174D	NM_001079533	NP_001073001	Q9BZB8	CPEB1_HUMAN	cytoplasmic polyadenylation element binding	405	RRM 1.|Necessary for stress granule assembly and correct localization in dcp1 bodies.				mRNA processing|regulation of translation	cell junction|cytoplasmic mRNA processing body|dendrite|postsynaptic density|postsynaptic membrane	nucleotide binding|RNA binding			ovary(1)|breast(1)	2			BRCA - Breast invasive adenocarcinoma(143;0.229)			GCTAACTCACCTCCTTGCAGC	0.517			NA											6	33					0	0	0.001168	0	0
NGRN	51335	broad.mit.edu	37	15	90808965	90808965	+	Silent	SNP	C	C	T			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr15:90808965C>T	uc002bpf.1	+	1	71	c.21C>T	c.(19-21)CTC>CTT	p.L7L	TTLL13_uc002bpe.1_Intron|NGRN_uc002bpg.1_5'UTR	NM_001033088	NP_001028260	Q9NPE2	NGRN_HUMAN	neugrin	7					neuron differentiation	extracellular region|nucleus				large_intestine(2)|ovary(1)	3	Melanoma(11;0.00551)|Lung NSC(78;0.0178)|all_lung(78;0.0378)		KIRC - Kidney renal clear cell carcinoma(17;0.0286)|BRCA - Breast invasive adenocarcinoma(143;0.0323)|Kidney(142;0.0514)			CCCTGAGTCTCTTGCTGGGCG	0.677			NA											5	24					0	0	0.001168	0	0
WASH3P	374666	broad.mit.edu	37	15	102515299	102515299	+	Missense_Mutation	SNP	G	G	A			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr15:102515299G>A	uc002cdi.2	+	9	1943	c.523G>A	c.(523-525)GGC>AGC	p.G175S	WASH3P_uc002cdl.2_Missense_Mutation_p.G175S|WASH3P_uc002cdk.2_RNA|WASH3P_uc002cdp.2_Missense_Mutation_p.G175S|WASH3P_uc010bpo.2_RNA|WASH3P_uc002cdq.2_RNA|WASH3P_uc002cdr.2_RNA	NR_003659				RecName: Full=WAS protein family homolog 2; AltName: Full=Protein FAM39B; AltName: Full=CXYorf1-like protein on chromosome 2;												0						TGGGGGCATCGGCAAGGCCAA	0.652			NA											3	14					0	0	0.004672	0	0
LUC7L	55692	broad.mit.edu	37	16	239215	239215	+	Missense_Mutation	SNP	C	C	G			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr16:239215C>G	uc002cgc.1	-	10	1209	c.1098G>C	c.(1096-1098)AAG>AAC	p.K366N	LUC7L_uc002cga.1_3'UTR|LUC7L_uc002cgd.1_RNA|LUC7L_uc002cge.1_3'UTR|LUC7L_uc002cgb.1_Missense_Mutation_p.K280N	NM_201412	NP_958815	Q9NQ29	LUC7L_HUMAN	LUC7-like isoform b	366							metal ion binding			central_nervous_system(1)	1		all_cancers(16;1.1e-06)|all_epithelial(16;2.71e-06)|Hepatocellular(16;0.000105)|Lung NSC(18;0.0138)|all_lung(18;0.0306)				CGCCGGCCTCCTTCTCTTCTG	0.552			NA											14	199					0	0	0.006122	0	0
PKD1	5310	broad.mit.edu	37	16	2147731	2147731	+	Missense_Mutation	SNP	C	C	G			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr16:2147731C>G	uc002cos.1	-	32	10427	c.10218G>C	c.(10216-10218)AAG>AAC	p.K3406N	PKD1_uc002cot.1_Missense_Mutation_p.K3405N|PKD1_uc010bse.1_RNA	NM_001009944	NP_001009944	P98161	PKD1_HUMAN	polycystin 1 isoform 1 precursor	3406	Cytoplasmic (Potential).				calcium-independent cell-matrix adhesion|homophilic cell adhesion|neuropeptide signaling pathway	basolateral plasma membrane|integral to plasma membrane	protein domain specific binding|sugar binding			central_nervous_system(2)|skin(1)	3						GAACCCACCTCTTAGAATCAT	0.587			NA											6	128					0	0	0.001984	0	0
THOC6	79228	broad.mit.edu	37	16	3074344	3074344	+	Missense_Mutation	SNP	C	C	T			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr16:3074344C>T	uc002ctb.2	+	1	313	c.17C>T	c.(16-18)CCG>CTG	p.P6L	HCFC1R1_uc002csx.1_5'Flank|HCFC1R1_uc002csy.1_5'Flank|HCFC1R1_uc002csz.1_5'Flank|THOC6_uc002ctd.2_Missense_Mutation_p.P6L|THOC6_uc002ctc.2_5'UTR|THOC6_uc002cta.2_5'UTR	NM_024339	NP_077315	Q86W42	THOC6_HUMAN	WD repeat domain 58 isoform 1	6					intronless viral mRNA export from host nucleus|mRNA processing|RNA splicing	THO complex part of transcription export complex	RNA binding			ovary(1)|central_nervous_system(1)	2						CGAGCTGTGCCGCTCGCGGTG	0.647			NA											5	36					0	0	0.001984	0	0
RUNDC2A	84127	broad.mit.edu	37	16	12142251	12142251	+	Silent	SNP	G	G	T			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr16:12142251G>T	uc002dbw.1	+	7	584	c.522G>T	c.(520-522)GCG>GCT	p.A174A		NM_032167	NP_115543	Q9HA26	RUN2A_HUMAN	RUN domain containing 2A	174	RUN.									ovary(1)	1						TACTCTTTGCGATTAACATCG	0.483			NA	T	CIITA	PMBL|Hodgkin Lymphona|								29	127					3.1745e-13	5.10445e-13	0.008361	1	0
MYH11	4629	broad.mit.edu	37	16	15815397	15815397	+	Missense_Mutation	SNP	G	G	C			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr16:15815397G>C	uc002ddy.2	-	32	4567	c.4460C>G	c.(4459-4461)TCC>TGC	p.S1487C	MYH11_uc002ddv.2_Missense_Mutation_p.S1494C|MYH11_uc002ddw.2_Missense_Mutation_p.S1487C|MYH11_uc002ddx.2_Missense_Mutation_p.S1494C|MYH11_uc010bvg.2_Missense_Mutation_p.S1319C|NDE1_uc010uzy.1_Intron|NDE1_uc002dds.2_Intron|MYH11_uc010bvh.2_Missense_Mutation_p.S193C|NDE1_uc002ddz.1_5'Flank	NM_002474	NP_002465	P35749	MYH11_HUMAN	smooth muscle myosin heavy chain 11 isoform	1487	Potential.				axon guidance|cardiac muscle fiber development|elastic fiber assembly|skeletal muscle myosin thick filament assembly|smooth muscle contraction	cytosol|melanosome|muscle myosin complex|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			ovary(6)|skin(3)|lung(2)|breast(2)|upper_aerodigestive_tract(1)|pancreas(1)	15						CCGAGCCAGGGACAGGGCCTT	0.537			NA	T	CBFB	AML								4	78					0	0	0.000248	0	0
SMG1	23049	broad.mit.edu	37	16	18826800	18826800	+	Missense_Mutation	SNP	G	G	C			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr16:18826800G>C	uc002dfm.2	-	59	10839	c.10476C>G	c.(10474-10476)ATC>ATG	p.I3492M	SMG1_uc010bwb.2_Missense_Mutation_p.I3352M|SMG1_uc010bwa.2_Missense_Mutation_p.I2223M	NM_015092	NP_055907	Q96Q15	SMG1_HUMAN	PI-3-kinase-related kinase SMG-1	3492					DNA repair|mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|peptidyl-serine phosphorylation|phosphatidylinositol phosphorylation|protein autophosphorylation	cytoplasm|nucleus	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			breast(5)|stomach(4)|lung(4)|kidney(2)|ovary(1)	16						AGGTGGGAGTGATTTCCTGGA	0.373			NA											4	113					0	0	0.000248	0	0
SEZ6L2	26470	broad.mit.edu	37	16	29899882	29899882	+	Missense_Mutation	SNP	C	C	A	rs143818590	byFrequency	TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr16:29899882C>A	uc002duq.3	-	6	1258	c.1018G>T	c.(1018-1020)GGT>TGT	p.G340C	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|SEZ6L2_uc002dup.3_Missense_Mutation_p.G270C|SEZ6L2_uc002dur.3_Missense_Mutation_p.G270C|SEZ6L2_uc002dus.3_Missense_Mutation_p.G226C|SEZ6L2_uc010vec.1_Missense_Mutation_p.G340C|SEZ6L2_uc010ved.1_Missense_Mutation_p.G296C	NM_201575	NP_963869	Q6UXD5	SE6L2_HUMAN	seizure related 6 homolog (mouse)-like 2 isoform	340	Sushi 1.|Extracellular (Potential).					endoplasmic reticulum membrane|integral to membrane|plasma membrane				ovary(1)|skin(1)	2						GGGGTTTCACCGTTCCAGGAT	0.627			NA											5	33					3.59834e-05	4.51587e-05	0.001168	1	0
SRCAP	10847	broad.mit.edu	37	16	30750800	30750800	+	Missense_Mutation	SNP	G	G	T			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr16:30750800G>T	uc002dze.1	+	34	9824	c.9439G>T	c.(9439-9441)GGG>TGG	p.G3147W	SRCAP_uc002dzf.2_RNA|SRCAP_uc002dzg.1_Missense_Mutation_p.G2942W	NM_006662	NP_006653	Q6ZRS2	SRCAP_HUMAN	Snf2-related CBP activator protein	3147					interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|nucleus|protein complex	ATP binding|DNA binding|helicase activity|histone acetyltransferase activity|transcription coactivator activity			ovary(3)|skin(1)	4			Colorectal(24;0.198)			CCCAGTTGGTGGGAGTCCTGG	0.642			NA											6	26					5.18039e-06	6.7716e-06	0.00308	1	0
HSD3B7	80270	broad.mit.edu	37	16	30999168	30999168	+	Missense_Mutation	SNP	C	C	A			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr16:30999168C>A	uc002eaf.2	+	7	880	c.774C>A	c.(772-774)TTC>TTA	p.F258L	HSD3B7_uc010cac.2_3'UTR|HSD3B7_uc002eag.2_3'UTR|HSD3B7_uc002eah.2_Missense_Mutation_p.F258L	NM_025193	NP_079469	Q9H2F3	3BHS7_HUMAN	hydroxy-delta-5-steroid dehydrogenase, 3 beta-	258					bile acid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	3-beta-hydroxy-delta5-steroid dehydrogenase activity|binding|cholest-5-ene-3-beta,7-alpha-diol 3-beta-dehydrogenase activity				0						AGGTATACTTCTGCTACGATG	0.647			NA											19	135					2.4624e-09	3.62004e-09	0.008871	1	0
ABCC11	85320	broad.mit.edu	37	16	48226557	48226557	+	Silent	SNP	G	G	T			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr16:48226557G>T	uc002eff.1	-	19	2930	c.2580C>A	c.(2578-2580)TCC>TCA	p.S860S	ABCC11_uc002efg.1_Silent_p.S860S|ABCC11_uc002efh.1_Silent_p.S860S|ABCC11_uc010vgk.1_RNA	NM_033151	NP_149163	Q96J66	ABCCB_HUMAN	ATP-binding cassette, sub-family C, member 11	860	ABC transmembrane type-1 2.					integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(3)|skin(2)|central_nervous_system(1)	6		all_cancers(37;0.127)|all_lung(18;0.132)|Breast(268;0.166)				GCTGGTAGAAGGACAGTTGAG	0.557			NA							Cerumen_Type				17	85					1.99824e-07	2.75183e-07	0.00499	1	0
NKD1	85407	broad.mit.edu	37	16	50667195	50667195	+	Missense_Mutation	SNP	C	C	G			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr16:50667195C>G	uc002egg.1	+	10	1140	c.916C>G	c.(916-918)CCA>GCA	p.P306A		NM_033119	NP_149110	Q969G9	NKD1_HUMAN	naked cuticle homolog 1	306					Wnt receptor signaling pathway	cytoplasm|plasma membrane	calcium ion binding|protein binding				0		all_cancers(37;0.229)		GBM - Glioblastoma multiforme(240;0.243)		CATCCACATCCCACACCGAAA	0.642			NA											5	118					0	0	0.001168	0	0
SF3B3	23450	broad.mit.edu	37	16	70602365	70602365	+	Silent	SNP	G	G	T			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr16:70602365G>T	uc002ezf.2	+	22	3343	c.3132G>T	c.(3130-3132)GTG>GTT	p.V1044V		NM_012426	NP_036558	Q15393	SF3B3_HUMAN	splicing factor 3b, subunit 3	1044					protein complex assembly	catalytic step 2 spliceosome|nucleoplasm|small nuclear ribonucleoprotein complex|U12-type spliceosomal complex	nucleic acid binding|protein binding			ovary(1)	1		Ovarian(137;0.0694)				ATGACACTGTGGCTGGGGCAG	0.483			NA											5	34					0.00116845	0.00135799	0.001168	1	0
GEMIN4	50628	broad.mit.edu	37	17	650508	650508	+	Nonsense_Mutation	SNP	C	C	A			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr17:650508C>A	uc002frs.1	-	2	894	c.775G>T	c.(775-777)GAG>TAG	p.E259*	GEMIN4_uc010vqa.1_Missense_Mutation_p.R171S	NM_015721	NP_056536	P57678	GEMI4_HUMAN	gemin 4	259					rRNA processing|spliceosomal snRNP assembly	Cajal body|cytosol|nucleolus|small nuclear ribonucleoprotein complex|spliceosomal complex	protein binding			ovary(2)|kidney(1)|skin(1)	4		Myeloproliferative disorder(207;0.204)		UCEC - Uterine corpus endometrioid carcinoma (25;0.022)		GCAGACACCTCCTGGGGGTCG	0.607			NA											17	155					1.99824e-07	2.75183e-07	0.00499	1	0
OR3A4	390756	broad.mit.edu	37	17	3214440	3214440	+	Missense_Mutation	SNP	T	T	G			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr17:3214440T>G	uc002fvi.2	+	1	902	c.836T>G	c.(835-837)ATC>AGC	p.I279S		NR_024128				RecName: Full=Olfactory receptor 3A4; AltName: Full=Olfactory receptor 17-24;          Short=OR17-24;											ovary(1)	1						GGCATTGGCATCCTCAACACT	0.567			NA											4	147					0	0	0.000248	0	0
SPNS3	201305	broad.mit.edu	37	17	4356383	4356383	+	Missense_Mutation	SNP	G	G	T			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr17:4356383G>T	uc002fxt.2	+	8	1040	c.996G>T	c.(994-996)AGG>AGT	p.R332S	SPNS3_uc002fxu.2_Missense_Mutation_p.R205S|SPNS3_uc002fxv.2_Missense_Mutation_p.R16S	NM_182538	NP_872344	Q6ZMD2	SPNS3_HUMAN	spinster homolog 3	332					lipid transport|transmembrane transport	integral to membrane				large_intestine(1)	1						CTGCGAGGAGGTACAAGAAAG	0.607			NA											18	125					2.94398e-08	4.16574e-08	0.007413	1	0
TP53	7157	broad.mit.edu	37	17	7579457	7579457	+	Missense_Mutation	SNP	G	G	A			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr17:7579457G>A	uc002gim.2	-	4	424	c.230C>T	c.(229-231)CCA>CTA	p.P77L	TP53_uc002gig.1_Missense_Mutation_p.P77L|TP53_uc002gih.2_Missense_Mutation_p.P77L|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_5'Flank|TP53_uc010cng.1_5'Flank|TP53_uc002gii.1_5'Flank|TP53_uc010cnh.1_Missense_Mutation_p.P77L|TP53_uc010cni.1_Missense_Mutation_p.P77L|TP53_uc002gij.2_Missense_Mutation_p.P77L|TP53_uc010cnj.1_5'Flank|TP53_uc002gin.2_Intron|TP53_uc002gio.2_Intron|TP53_uc010vug.1_Missense_Mutation_p.P38L|TP53_uc010cnk.1_Missense_Mutation_p.P92L	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	77	Interaction with WWOX.|Interaction with HRMT1L2.		P -> A (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.0?(7)|p.A76_S90del15(3)|p.P77A(3)|p.G59fs*23(3)|p.V73fs*9(1)|p.R65fs*38(1)|p.P77fs*71(1)|p.D48fs*55(1)|p.P77fs*46(1)|p.P13fs*18(1)|p.S33fs*23(1)|p.A74fs*71(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		AGGAGCTGCTGGTGCAGGGGC	0.617	Pancreas(47;798 1329 9957 10801)		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumensyndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			15	132					0	0	0.00245	0	0
DNAH2	146754	broad.mit.edu	37	17	7662780	7662780	+	Missense_Mutation	SNP	G	G	T			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr17:7662780G>T	uc002giu.1	+	15	2503	c.2489G>T	c.(2488-2490)CGC>CTC	p.R830L		NM_020877	NP_065928	Q9P225	DYH2_HUMAN	dynein heavy chain domain 3	830	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(6)|skin(6)|central_nervous_system(1)	13		all_cancers(10;4.66e-07)|Prostate(122;0.081)				CGGCTGGACCGCATGATGGAG	0.527			NA											14	55					1.02788e-11	1.60271e-11	0.00499	1	0
C17orf68	80169	broad.mit.edu	37	17	8138501	8138501	+	Nonsense_Mutation	SNP	G	G	A			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr17:8138501G>A	uc002gkq.3	-	8	1368	c.1309C>T	c.(1309-1311)CAG>TAG	p.Q437*	C17orf68_uc010cnv.2_RNA	NM_025099	NP_079375	Q2NKJ3	CTC1_HUMAN	alpha accessory factor 132	437					positive regulation of DNA replication|telomere maintenance	Stn1-Ten1 complex	protein binding|single-stranded DNA binding				0						CCAGGCTTCTGACGAGAGAAG	0.627			NA											13	103					0	0	0.001368	0	0
MYH3	4621	broad.mit.edu	37	17	10545805	10545805	+	Missense_Mutation	SNP	A	A	T			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr17:10545805A>T	uc002gmq.1	-	15	1894	c.1817T>A	c.(1816-1818)GTG>GAG	p.V606E		NM_002470	NP_002461	P11055	MYH3_HUMAN	myosin, heavy chain 3, skeletal muscle,	606	Myosin head-like.				muscle filament sliding|muscle organ development	cytosol|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(4)|central_nervous_system(2)|pancreas(1)	7						CAGCCCAACCACAGTCTCGTT	0.557			NA											6	114					0	0	0.001168	0	0
ELAC2	60528	broad.mit.edu	37	17	12905609	12905609	+	Missense_Mutation	SNP	G	G	C			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr17:12905609G>C	uc002gnz.3	-	14	1381	c.1286C>G	c.(1285-1287)CCC>CGC	p.P429R	ELAC2_uc002gnu.3_5'Flank|ELAC2_uc002gnv.3_Missense_Mutation_p.P57R|ELAC2_uc002gnw.3_Missense_Mutation_p.P87R|ELAC2_uc002gnx.3_Missense_Mutation_p.P189R|ELAC2_uc010vvo.1_Missense_Mutation_p.P227R|ELAC2_uc010vvp.1_Missense_Mutation_p.P410R|ELAC2_uc010vvq.1_Missense_Mutation_p.P428R|ELAC2_uc010vvr.1_Missense_Mutation_p.P389R	NM_018127	NP_060597	Q9BQ52	RNZ2_HUMAN	elaC homolog 2 isoform 1	429					tRNA processing	nucleus	endonuclease activity|metal ion binding|protein binding				0						CTCCCTCCTGGGACGGAGCTG	0.413			NA							Hereditary_Prostate_Cancer				5	58					0	0	0.001984	0	0
CCDC144A	9720	broad.mit.edu	37	17	16612677	16612677	+	Missense_Mutation	SNP	G	G	C			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr17:16612677G>C	uc002gqk.1	+	5	1382	c.1306G>C	c.(1306-1308)GTT>CTT	p.V436L	CCDC144A_uc002gql.1_Intron|LOC162632_uc010cpj.1_5'Flank	NM_014695	NP_055510	A2RUR9	C144A_HUMAN	coiled-coil domain containing 144A	436											0						CCCAGAAGTGGTTATGGTTGA	0.353			NA											4	53					0	0	0.000602	0	0
CCDC144A	9720	broad.mit.edu	37	17	16612733	16612733	+	Missense_Mutation	SNP	G	G	C			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr17:16612733G>C	uc002gqk.1	+	5	1438	c.1362G>C	c.(1360-1362)ATG>ATC	p.M454I	CCDC144A_uc002gql.1_Intron|LOC162632_uc010cpj.1_5'Flank	NM_014695	NP_055510	A2RUR9	C144A_HUMAN	coiled-coil domain containing 144A	454											0						CAAAAAATATGAACCAAAATA	0.353			NA											10	67					0	0	0.008291	0	0
SLC5A10	125206	broad.mit.edu	37	17	18922736	18922736	+	Silent	SNP	G	G	T			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr17:18922736G>T	uc002guu.1	+	12	1283	c.1242G>T	c.(1240-1242)CGG>CGT	p.R414R	SLC5A10_uc002gur.1_Missense_Mutation_p.W384C|SLC5A10_uc002gut.1_Silent_p.R430R|SLC5A10_uc002guv.1_Silent_p.R387R|SLC5A10_uc010vyl.1_Silent_p.R378R|SLC5A10_uc002gux.1_RNA	NM_001042450	NP_001035915	A0PJK1	SC5AA_HUMAN	solute carrier family 5 (sodium/glucose	414	Helical; (Potential).				sodium ion transport|transmembrane transport	integral to membrane	transporter activity			ovary(1)	1						TCGCCTGCAGGCTGGTCATAG	0.592			NA											4	14					5.9392e-07	8.08074e-07	0.001168	1	0
KSR1	8844	broad.mit.edu	37	17	25924462	25924462	+	Missense_Mutation	SNP	G	G	A			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr17:25924462G>A	uc010crg.2	+	10	1502	c.1057G>A	c.(1057-1059)GCT>ACT	p.A353T	KSR1_uc002gzj.1_RNA|KSR1_uc002gzm.2_Missense_Mutation_p.A154T	NM_014238	NP_055053	Q8IVT5	KSR1_HUMAN	kinase suppressor of ras	488					Ras protein signal transduction	cytoplasm|membrane	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			lung(3)|central_nervous_system(1)	4	Lung NSC(42;0.00836)		BRCA - Breast invasive adenocarcinoma(3;0.00122)	UCEC - Uterine corpus endometrioid carcinoma (53;0.168)		CAACTTCCCAGGTACCACATC	0.597	Esophageal Squamous(88;1120 1336 6324 10502 16832)		NA											3	13					0	0	0.004672	0	0
NOS2	4843	broad.mit.edu	37	17	26087144	26087144	+	Missense_Mutation	SNP	A	A	C			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr17:26087144A>C	uc002gzu.2	-	25	3335	c.3071T>G	c.(3070-3072)ATC>AGC	p.I1024S		NM_000625	NP_000616	P35228	NOS2_HUMAN	nitric oxide synthase 2A	1024					arginine catabolic process|defense response to Gram-negative bacterium|innate immune response in mucosa|nitric oxide biosynthetic process|peptidyl-cysteine S-nitrosylation|platelet activation|positive regulation of killing of cells of other organism|positive regulation of leukocyte mediated cytotoxicity|regulation of cellular respiration|regulation of insulin secretion|superoxide metabolic process	cytosol|nucleus	arginine binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|protein homodimerization activity|tetrahydrobiopterin binding			skin(2)|ovary(1)|breast(1)	4					Dexamethasone(DB01234)|Hydrocortisone(DB00741)|L-Arginine(DB00125)|L-Citrulline(DB00155)	CTCCTGGTAGATGTGGTCCTC	0.627			NA									OREG0024268	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	5	67					0	0	0.000602	0	0
EFCAB5	374786	broad.mit.edu	37	17	28417673	28417673	+	Missense_Mutation	SNP	A	A	G			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr17:28417673A>G	uc002het.2	+	20	4110	c.3918A>G	c.(3916-3918)ATA>ATG	p.I1306M	EFCAB5_uc010cse.2_Missense_Mutation_p.I1061M|EFCAB5_uc010csf.2_Intron	NM_198529	NP_940931	A4FU69	EFCB5_HUMAN	EF-hand calcium binding domain 5 isoform a	1306							calcium ion binding			ovary(1)|skin(1)	2						CTGGAGAGATAAAGAAAAAAT	0.368			NA											25	142					0	0	0.004656	0	0
ACCN1	40	broad.mit.edu	37	17	31439050	31439050	+	Missense_Mutation	SNP	G	G	T			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr17:31439050G>T	uc002hhu.2	-	2	865	c.591C>A	c.(589-591)AAC>AAA	p.N197K	ACCN1_uc002hht.2_Missense_Mutation_p.N248K	NM_001094	NP_001085	Q16515	ACCN1_HUMAN	amiloride-sensitive cation channel 1, neuronal	197	Extracellular (By similarity).				central nervous system development|peripheral nervous system development|synaptic transmission	integral to plasma membrane	ligand-gated sodium channel activity|protein binding			ovary(2)|large_intestine(1)|central_nervous_system(1)	4		Breast(31;0.042)|Ovarian(249;0.202)		UCEC - Uterine corpus endometrioid carcinoma (308;0.13)|BRCA - Breast invasive adenocarcinoma(366;0.215)	Amiloride(DB00594)	CCTCGCCTGAGTTAAACATGT	0.517			NA											7	27					0.00198382	0.0022822	0.001984	1	0
SLFN12	55106	broad.mit.edu	37	17	33749524	33749524	+	Missense_Mutation	SNP	T	T	C			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr17:33749524T>C	uc002hji.3	-	2	901	c.524A>G	c.(523-525)AAT>AGT	p.N175S	SLFN12_uc002hjj.3_Missense_Mutation_p.N175S|SLFN12_uc010cts.2_Missense_Mutation_p.N175S	NM_018042	NP_060512	Q8IYM2	SLN12_HUMAN	schlafen family member 12	175							ATP binding			skin(1)	1		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		CTTCATGTTATTTTCTTCTTG	0.383			NA											6	97					0	0	0.001168	0	0
KRT37	8688	broad.mit.edu	37	17	39580631	39580631	+	Missense_Mutation	SNP	C	C	G			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr17:39580631C>G	uc002hwp.1	-	1	192	c.145G>C	c.(145-147)GTG>CTG	p.V49L	uc002hwo.1_RNA	NM_003770	NP_003761	O76014	KRT37_HUMAN	keratin 37	49	Head.					intermediate filament	structural molecule activity			skin(1)	1		Breast(137;0.000496)				GCGTGTGCCACGTTGGCCAAG	0.617			NA											12	63					0	0	0.001855	0	0
KRT36	8689	broad.mit.edu	37	17	39644973	39644973	+	Silent	SNP	G	G	A			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr17:39644973G>A	uc002hwt.2	-	2	463	c.463C>T	c.(463-465)CTG>TTG	p.L155L		NM_003771	NP_003762	O76013	KRT36_HUMAN	keratin 36	155	Rod.|Coil 1B.					intermediate filament	protein binding|structural constituent of epidermis				0		Breast(137;0.000286)				TTAGTCAGCAGGATCTGGGGA	0.572			NA											7	103					0	0	0.001984	0	0
WNK4	65266	broad.mit.edu	37	17	40939540	40939540	+	Missense_Mutation	SNP	C	C	G			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr17:40939540C>G	uc002ibj.2	+	7	1742	c.1721C>G	c.(1720-1722)GCC>GGC	p.A574G	WNK4_uc010wgx.1_Missense_Mutation_p.A238G|WNK4_uc002ibk.1_Missense_Mutation_p.A346G|WNK4_uc010wgy.1_5'UTR	NM_032387	NP_115763	Q96J92	WNK4_HUMAN	WNK lysine deficient protein kinase 4	574					intracellular protein kinase cascade	tight junction	ATP binding|protein serine/threonine kinase activity			ovary(3)|skin(3)|stomach(1)	7		Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.0749)		TTCCGCCACGCCAGCTACTCA	0.622	Esophageal Squamous(6;201 374 4964 23855 42828)		NA											18	142					0	0	0.008871	0	0
G6PC3	92579	broad.mit.edu	37	17	42153250	42153250	+	Missense_Mutation	SNP	C	C	A			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr17:42153250C>A	uc002iex.2	+	6	1096	c.880C>A	c.(880-882)CTG>ATG	p.L294M	G6PC3_uc002iey.2_Missense_Mutation_p.L169M|G6PC3_uc010czo.2_Missense_Mutation_p.L150M|G6PC3_uc002iez.2_Missense_Mutation_p.L169M|G6PC3_uc002ifb.2_Missense_Mutation_p.L169M|G6PC3_uc002ifc.2_Missense_Mutation_p.L103M	NM_138387	NP_612396	Q9BUM1	G6PC3_HUMAN	glucose-6-phosphatase catalytic subunit 3	294	Helical; (Potential).				gluconeogenesis|transmembrane transport	endoplasmic reticulum membrane|integral to membrane	glucose-6-phosphatase activity			skin(1)	1		Breast(137;0.00637)|Prostate(33;0.0313)		BRCA - Breast invasive adenocarcinoma(366;0.113)		CATGGGGCTGCTGGGCCCCCT	0.612			NA											10	65					6.40141e-05	7.91091e-05	0.000978	1	0
ITGB3	3690	broad.mit.edu	37	17	45363775	45363775	+	Missense_Mutation	SNP	C	C	A			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr17:45363775C>A	uc002ilj.2	+	5	784	c.764C>A	c.(763-765)GCT>GAT	p.A255D	ITGB3_uc002ili.1_Missense_Mutation_p.A255D|ITGB3_uc010wkr.1_RNA	NM_000212	NP_000203	P05106	ITB3_HUMAN	integrin beta chain, beta 3 precursor	255	VWFA.|Extracellular (Potential).				activation of protein kinase activity|angiogenesis involved in wound healing|axon guidance|cell-matrix adhesion|integrin-mediated signaling pathway|interspecies interaction between organisms|leukocyte migration|negative regulation of lipid storage|negative regulation of lipid transport|negative regulation of lipoprotein metabolic process|negative regulation of low-density lipoprotein particle receptor biosynthetic process|negative regulation of macrophage derived foam cell differentiation|platelet activation|platelet degranulation|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of vascular endothelial growth factor receptor signaling pathway|regulation of bone resorption|smooth muscle cell migration|tube development	alphav-beta3 integrin-vitronectin complex|integrin complex|platelet alpha granule membrane	cell adhesion molecule binding|identical protein binding|platelet-derived growth factor receptor binding|receptor activity|vascular endothelial growth factor receptor 2 binding			central_nervous_system(5)|large_intestine(1)	6					Abciximab(DB00054)|Tirofiban(DB00775)	aTCATGCAGGCTACAGTCTGT	0.338			NA											12	54					2.80697e-09	4.10529e-09	0.000978	1	0
TEX14	56155	broad.mit.edu	37	17	56650541	56650541	+	Splice_Site	SNP	C	C	G			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr17:56650541C>G	uc010dcz.1	-	24	3767	c.3649_splice	c.e24+1	p.G1217_splice	TEX14_uc002iwr.1_Splice_Site_p.G1211_splice|TEX14_uc002iws.1_Splice_Site_p.G1171_splice|TEX14_uc010dda.1_Splice_Site_p.G951_splice	NM_198393	NP_938207	Q8IWB6	TEX14_HUMAN	testis expressed sequence 14 isoform a							cytoplasm	ATP binding|protein kinase activity			stomach(4)|lung(3)|breast(3)|ovary(3)|upper_aerodigestive_tract(1)|large_intestine(1)|skin(1)|pancreas(1)	17	Medulloblastoma(34;0.127)|all_neural(34;0.237)					CCTGTGATTACCTGGGCTGAG	0.502			NA											15	155					0	0	0.00245	0	0
RNF157	114804	broad.mit.edu	37	17	74150404	74150404	+	Silent	SNP	A	A	G			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr17:74150404A>G	uc002jqz.2	-	17	1839	c.1770T>C	c.(1768-1770)AAT>AAC	p.N590N	RNF157_uc002jra.2_Silent_p.N568N|uc002jrb.1_5'Flank	NM_052916	NP_443148	Q96PX1	RN157_HUMAN	ring finger protein 157	590							zinc ion binding			ovary(1)	1			LUSC - Lung squamous cell carcinoma(166;0.187)			CTATAACATCATTTCCCTAGG	0.423	GBM(186;507 2120 27388 27773 52994)		NA											28	156					0	0	0.007291	0	0
CARD14	79092	broad.mit.edu	37	17	78175572	78175572	+	Missense_Mutation	SNP	C	C	G			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr17:78175572C>G	uc002jxw.1	+	14	2076	c.1881C>G	c.(1879-1881)TTC>TTG	p.F627L	CARD14_uc002jxt.1_RNA|CARD14_uc002jxv.2_Missense_Mutation_p.F627L|CARD14_uc010wud.1_Intron	NM_024110	NP_077015	Q9BXL6	CAR14_HUMAN	caspase recruitment domain protein 14 isoform 1	627	PDZ.			DYEASEPLFKAVLEDTTLEEAVGLLRRVDGFCCLSVKVNTD GYKRLLQDLEAK -> SRARPLLSPGLLMGTVAAGGVTQAD FTSPRRCRSTLGWASALSWADVKRSAHL (in Ref. 4; AAH01326).	activation of NF-kappaB-inducing kinase activity|positive regulation of protein phosphorylation|regulation of apoptosis	aggresome|cytoplasm|plasma membrane	CARD domain binding			ovary(4)|skin(1)	5	all_neural(118;0.0952)		OV - Ovarian serous cystadenocarcinoma(97;0.017)|BRCA - Breast invasive adenocarcinoma(99;0.0908)			AGCCCTTGTTCAAGGCAGTCC	0.592			NA											5	74					0	0	0.00308	0	0
Unknown	0	broad.mit.edu	37	17	78280178	78280178	+	Missense_Mutation	SNP	G	G	T			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr17:78280178G>T	uc002jyf.2	+	12	2480	c.2337G>T	c.(2335-2337)GAG>GAT	p.E779D	uc002jyg.1_Missense_Mutation_p.E510D	NM_020954	NP_066005			hypothetical protein LOC57714												NA						ACTTCATTGAGCACCTGGGTC	0.483			NA											21	77					2.27731e-05	2.90305e-05	0.001882	1	0
EPB41L3	23136	broad.mit.edu	37	18	5395092	5395092	+	Missense_Mutation	SNP	C	C	A			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr18:5395092C>A	uc002kmt.1	-	21	3213	c.3127G>T	c.(3127-3129)GGG>TGG	p.G1043W	EPB41L3_uc010wzh.1_Missense_Mutation_p.G874W|EPB41L3_uc002kmu.1_Missense_Mutation_p.G821W|EPB41L3_uc010dkq.1_Missense_Mutation_p.G712W|EPB41L3_uc002kms.1_Missense_Mutation_p.G278W|EPB41L3_uc010wze.1_Missense_Mutation_p.G348W|EPB41L3_uc010wzf.1_Missense_Mutation_p.G340W|EPB41L3_uc010wzg.1_Missense_Mutation_p.G315W|EPB41L3_uc010dkr.2_Missense_Mutation_p.G435W	NM_012307	NP_036439	Q9Y2J2	E41L3_HUMAN	erythrocyte membrane protein band 4.1-like 3	1043	Carboxyl-terminal (CTD).				cortical actin cytoskeleton organization	cell-cell junction|cytoplasm|cytoskeleton|extrinsic to membrane	actin binding|structural molecule activity			ovary(5)	5						TCTGCATCCCCCGTGATGACT	0.448			NA											20	94					1.28384e-07	1.78101e-07	0.001882	1	0
EPB41L3	23136	broad.mit.edu	37	18	5443878	5443878	+	Missense_Mutation	SNP	T	T	C			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr18:5443878T>C	uc002kmt.1	-	5	574	c.488A>G	c.(487-489)AAT>AGT	p.N163S	EPB41L3_uc010wzh.1_Missense_Mutation_p.N163S|EPB41L3_uc002kmu.1_Missense_Mutation_p.N163S|EPB41L3_uc010dkq.1_Missense_Mutation_p.N54S|EPB41L3_uc010dks.1_Missense_Mutation_p.N185S|EPB41L3_uc002kmv.1_Missense_Mutation_p.N54S	NM_012307	NP_036439	Q9Y2J2	E41L3_HUMAN	erythrocyte membrane protein band 4.1-like 3	163	FERM.				cortical actin cytoskeleton organization	cell-cell junction|cytoplasm|cytoskeleton|extrinsic to membrane	actin binding|structural molecule activity			ovary(5)	5						GTCCAACCAATTCTGAAAAGG	0.353			NA											6	106					0	0	0.001984	0	0
SLC14A2	8170	broad.mit.edu	37	18	43249369	43249369	+	Missense_Mutation	SNP	C	C	G			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr18:43249369C>G	uc010dnj.2	+	17	2456	c.2135C>G	c.(2134-2136)GCC>GGC	p.A712G	SLC14A2_uc002lbe.2_Missense_Mutation_p.A712G	NM_007163	NP_009094	Q15849	UT2_HUMAN	solute carrier family 14 (urea transporter),	712	Helical; (Potential).					apical plasma membrane|integral to membrane|membrane fraction	protein binding|urea transmembrane transporter activity			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)|skin(1)	4						TACCTGGCAGCCACGGGCCAC	0.572			NA											25	114					0	0	0.004656	0	0
SERPINB4	6318	broad.mit.edu	37	18	61305132	61305132	+	Missense_Mutation	SNP	C	C	A	rs144633926	byFrequency	TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr18:61305132C>A	uc002ljf.2	-	8	1080	c.994G>T	c.(994-996)GCC>TCC	p.A332S	SERPINB4_uc002lje.2_Missense_Mutation_p.A311S|SERPINB4_uc002ljg.2_Missense_Mutation_p.A332S	NM_002974	NP_002965	P48594	SPB4_HUMAN	serine (or cysteine) proteinase inhibitor, clade	332					immune response|regulation of proteolysis	cytoplasm|extracellular region	protein binding|serine-type endopeptidase inhibitor activity			ovary(2)|lung(1)	3						TCCACAAAGGCCTTGTGTAGG	0.493			NA											7	138					2.0095e-06	2.68883e-06	0.001984	1	0
CCDC102B	79839	broad.mit.edu	37	18	66721318	66721318	+	Nonsense_Mutation	SNP	G	G	T			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr18:66721318G>T	uc002lkk.2	+	10	1709	c.1486G>T	c.(1486-1488)GAG>TAG	p.E496*	CCDC102B_uc002lki.2_Nonsense_Mutation_p.E496*	NM_001093729	NP_001087198	Q68D86	C102B_HUMAN	coiled-coil domain containing 102B	496	Potential.									ovary(1)|lung(1)|skin(1)	3		Esophageal squamous(42;0.0559)|Colorectal(73;0.0604)				TCTGGATGAAGAGAAAGAAAG	0.333			NA											15	104					6.72482e-11	1.0315e-10	0.003163	1	0
ZNF516	9658	broad.mit.edu	37	18	74154561	74154561	+	Missense_Mutation	SNP	T	T	G			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr18:74154561T>G	uc010dqx.1	-	2	685	c.450A>C	c.(448-450)AGA>AGC	p.R150S	ZNF516_uc002lme.2_RNA	NM_014643	NP_055458	Q92618	ZN516_HUMAN	zinc finger protein 516	150					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Prostate(75;0.0869)|Esophageal squamous(42;0.129)		OV - Ovarian serous cystadenocarcinoma(15;7.64e-06)|BRCA - Breast invasive adenocarcinoma(31;0.238)		GCAGCAGGACTCTGCCGCTGT	0.716			NA											4	17					0	0	0.000248	0	0
CTDP1	9150	broad.mit.edu	37	18	77455261	77455261	+	Silent	SNP	G	G	T	rs139441883		TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr18:77455261G>T	uc002lnh.1	+	2	498	c.351G>T	c.(349-351)CCG>CCT	p.P117P	CTDP1_uc002lni.1_Silent_p.P117P|CTDP1_uc010drd.1_Silent_p.P117P	NM_004715	NP_004706	Q9Y5B0	CTDP1_HUMAN	CTD (carboxy-terminal domain, RNA polymerase II,	117					positive regulation of viral transcription|protein dephosphorylation|transcription elongation from RNA polymerase II promoter|viral reproduction	nucleoplasm	CTD phosphatase activity|DNA-directed RNA polymerase activity				0		Esophageal squamous(42;0.0157)|Melanoma(33;0.144)		OV - Ovarian serous cystadenocarcinoma(15;5.2e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0277)		GCAGCCACCCGGTTGTCATGA	0.468			NA											12	71					2.80697e-09	4.10529e-09	0.000978	1	0
STK11	6794	broad.mit.edu	37	19	1207120	1207120	+	Nonsense_Mutation	SNP	G	G	T			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr19:1207120G>T	uc002lrl.1	+	1	1323	c.208G>T	c.(208-210)GAG>TAG	p.E70*		NM_000455	NP_000446	Q15831	STK11_HUMAN	serine/threonine protein kinase 11	70	Protein kinase.				anoikis|cell cycle arrest|energy reserve metabolic process|insulin receptor signaling pathway|positive regulation of transforming growth factor beta receptor signaling pathway|regulation of fatty acid biosynthetic process|regulation of fatty acid oxidation	cytosol|nucleus	ATP binding|magnesium ion binding|protein serine/threonine kinase activity	p.0?(19)|p.?(3)|p.G52_P179del(1)|p.E70fs*26(1)|p.E70*(1)		lung(174)|cervix(35)|skin(15)|large_intestine(12)|pancreas(6)|gastrointestinal_tract_(site_indeterminate)(5)|stomach(4)|ovary(4)|breast(2)|upper_aerodigestive_tract(1)|testis(1)|liver(1)|biliary_tract(1)|small_intestine(1)|urinary_tract(1)|oesophagus(1)|prostate(1)|kidney(1)	266		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;7.93e-06)|all_lung(49;1.25e-05)|Breast(49;0.000172)|Renal(1328;0.0183)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|Lung(535;0.00942)|STAD - Stomach adenocarcinoma(1328;0.18)		GCTGGACTCGGAGACGCTGTG	0.607			14	D|Mis|N|F|S		NSCLC|pancreatic	jejunal harmartoma|ovarian|testicular|pancreatic			Peutz-Jeghers_syndrome	TSP Lung(3;<1E-08)			8	26					0.000157383	0.000190747	0.00308	1	0
MBD3	53615	broad.mit.edu	37	19	1578464	1578464	+	Missense_Mutation	SNP	C	C	A			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr19:1578464C>A	uc002ltl.1	-	6	773	c.751G>T	c.(751-753)GTG>TTG	p.V251L	uc002lti.1_5'Flank|MBD3_uc002ltj.2_Missense_Mutation_p.V251L|MBD3_uc002ltk.2_Missense_Mutation_p.V219L	NM_003926	NP_003917	O95983	MBD3_HUMAN	methyl-CpG binding domain protein 3	251					transcription, DNA-dependent	NuRD complex	DNA binding|protein binding			ovary(1)|pancreas(1)|skin(1)	3		Acute lymphoblastic leukemia(61;3.02e-13)|all_hematologic(61;4.32e-09)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|Lung(535;0.179)|STAD - Stomach adenocarcinoma(1328;0.18)		AGCTCCTCCACGTGCGCCAGC	0.542			NA											14	60					3.27435e-08	4.62165e-08	0.00245	1	0
SAFB2	9667	broad.mit.edu	37	19	5612565	5612565	+	Missense_Mutation	SNP	G	G	T			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr19:5612565G>T	uc002mcd.2	-	6	832	c.620C>A	c.(619-621)TCC>TAC	p.S207Y	SAFB2_uc010xio.1_Missense_Mutation_p.S207Y|SAFB2_uc010xip.1_RNA	NM_014649	NP_055464	Q14151	SAFB2_HUMAN	scaffold attachment factor B2	207					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|nucleotide binding|protein binding|RNA binding				0				UCEC - Uterine corpus endometrioid carcinoma (162;0.000228)		CTCCAAAAGGGATTCTTCAAT	0.338	Ovarian(127;888 1728 23957 44128 52668)		NA											9	44					1.76689e-08	2.52541e-08	0.006214	1	0
TUBB4	10382	broad.mit.edu	37	19	6495433	6495433	+	Silent	SNP	G	G	A			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr19:6495433G>A	uc002mfg.1	-	4	1184	c.1077C>T	c.(1075-1077)CGC>CGT	p.R359R	TUBB4_uc002mff.1_Silent_p.R287R|MIR220B_hsa-mir-220b|MI0005529_5'Flank	NM_006087	NP_006078	P04350	TBB4_HUMAN	tubulin, beta 4	359					'de novo' posttranslational protein folding|G2/M transition of mitotic cell cycle|microtubule-based movement|protein polymerization	cytosol|microtubule	GTP binding|GTPase activity|protein binding|structural molecule activity			ovary(2)	2		Hepatocellular(1079;0.00213)|Renal(1328;0.0183)		Lung(535;3.23e-05)|STAD - Stomach adenocarcinoma(1328;8.24e-05)|GBM - Glioblastoma multiforme(1328;0.00839)|READ - Rectum adenocarcinoma(264;0.155)		TCTTCAGGCCGCGGGGCGGGA	0.622			NA											41	167					0	0	0.007835	0	0
MUC16	94025	broad.mit.edu	37	19	9013855	9013855	+	Silent	SNP	G	G	T			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr19:9013855G>T	uc002mkp.2	-	33	38739	c.38535C>A	c.(38533-38535)CCC>CCA	p.P12845P	MUC16_uc010xki.1_5'Flank	NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	12847	Extracellular (Potential).			Missing (in Ref. 3; AAK74120).	cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						ATGTAGGGCTGGGGAGGGAGG	0.478			NA											8	29					5.18039e-06	6.7716e-06	0.00308	1	0
RGL3	57139	broad.mit.edu	37	19	11527319	11527319	+	Missense_Mutation	SNP	C	C	A			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr19:11527319C>A	uc002mrp.2	-	4	458	c.394G>T	c.(394-396)GTA>TTA	p.V132L	RGL3_uc002mrn.2_5'UTR|RGL3_uc002mrm.2_5'UTR|RGL3_uc002mro.2_Missense_Mutation_p.V132L|RGL3_uc002mrq.2_3'UTR	NM_001035223	NP_001030300	Q3MIN7	RGL3_HUMAN	ral guanine nucleotide dissociation	132	N-terminal Ras-GEF.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	intracellular				ovary(1)	1						AGATCTTGTACCGCTGTCTTC	0.567	GBM(174;751 2067 17998 27979 33959)		NA											28	95					8.16721e-17	1.35561e-16	0.002096	1	0
ZNF439	90594	broad.mit.edu	37	19	11978327	11978327	+	Missense_Mutation	SNP	G	G	T			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr19:11978327G>T	uc002mss.2	+	3	571	c.443G>T	c.(442-444)TGT>TTT	p.C148F	ZNF439_uc002msr.2_Missense_Mutation_p.C12F	NM_152262	NP_689475	Q8NDP4	ZN439_HUMAN	zinc finger protein 439	148					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1						CACAAGGCATGTGAATGTCAG	0.428			NA											45	148					3.05275e-18	5.112e-18	0.003214	1	0
OR10H5	284433	broad.mit.edu	37	19	15905246	15905246	+	Silent	SNP	C	C	T			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr19:15905246C>T	uc010xos.1	+	1	388	c.388C>T	c.(388-390)CTG>TTG	p.L130L		NM_001004466	NP_001004466	Q8NGA6	O10H5_HUMAN	olfactory receptor, family 10, subfamily H,	130	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						CTGCCACCCCCTGCGTTACAA	0.627			NA											6	62					0	0	0.001168	0	0
ZNF208	7757	broad.mit.edu	37	19	22157095	22157095	+	Missense_Mutation	SNP	A	A	T			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr19:22157095A>T	uc002nqp.2	-	4	890	c.741T>A	c.(739-741)CAT>CAA	p.H247Q	ZNF208_uc002nqo.1_Intron|ZNF208_uc010ecw.1_5'Flank	NM_007153	NP_009084			zinc finger protein 208											ovary(5)|skin(2)	7		all_lung(12;0.0961)|Lung NSC(12;0.103)				GAATTACCTTATGTTTAGTAA	0.353			NA											4	56					0	0	0.000248	0	0
ZNF599	148103	broad.mit.edu	37	19	35258315	35258315	+	Silent	SNP	C	C	T	rs147712651		TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr19:35258315C>T	uc010edn.1	-	3	535	c.147G>A	c.(145-147)GGG>GGA	p.G49G	ZNF599_uc010edm.1_Silent_p.G12G|ZNF599_uc010xsd.1_RNA|ZNF599_uc010edo.1_RNA	NM_001007248	NP_001007249	Q96NL3	ZN599_HUMAN	zinc finger protein 599	49	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|skin(1)	2	all_lung(56;1.13e-07)|Lung NSC(56;1.81e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.138)			GAACAGGATGCCCTGTGCATG	0.453			NA											3	53					0	0	0.000248	0	0
ZFP14	57677	broad.mit.edu	37	19	36831713	36831713	+	Missense_Mutation	SNP	G	G	A			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr19:36831713G>A	uc002odx.1	-	4	1108	c.1015C>T	c.(1015-1017)CCC>TCC	p.P339S	ZFP14_uc010xtd.1_Missense_Mutation_p.P340S|ZFP14_uc010eex.1_Missense_Mutation_p.P339S	NM_020917	NP_065968	Q9HCL3	ZFP14_HUMAN	zinc finger protein 14-like	339					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1	Esophageal squamous(110;0.162)					CATTCATAGGGTTTCTCACCA	0.393			NA											23	76					0	0	0.00278	0	0
ZNF260	339324	broad.mit.edu	37	19	37005662	37005662	+	Missense_Mutation	SNP	C	C	G			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr19:37005662C>G	uc002oee.1	-	4	1323	c.479G>C	c.(478-480)GGA>GCA	p.G160A	ZNF260_uc002oed.1_Missense_Mutation_p.G157A|ZNF260_uc010eey.1_Missense_Mutation_p.G157A|ZNF260_uc002oef.1_Missense_Mutation_p.G157A	NM_001012756	NP_001012774	Q3ZCT1	ZN260_HUMAN	zinc finger protein 260	160					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	Esophageal squamous(110;0.162)					TGGTTTTTCTCCAGTATGAAT	0.393			NA											25	212					0	0	0.005443	0	0
RYR1	6261	broad.mit.edu	37	19	38997148	38997148	+	Missense_Mutation	SNP	C	C	G			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr19:38997148C>G	uc002oit.2	+	56	8784	c.8654C>G	c.(8653-8655)ACG>AGG	p.T2885R	RYR1_uc002oiu.2_Missense_Mutation_p.T2885R|RYR1_uc002oiv.1_5'UTR	NM_000540	NP_000531	P21817	RYR1_HUMAN	skeletal muscle ryanodine receptor isoform 1	2885	6 X approximate repeats.|Cytoplasmic.|6.				muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(7)|pancreas(2)|breast(1)|central_nervous_system(1)|skin(1)	12	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	TACCACAACACGTGGGGACGG	0.313			NA											5	32					0	0	0.001168	0	0
RYR1	6261	broad.mit.edu	37	19	39001357	39001357	+	Missense_Mutation	SNP	A	A	G			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr19:39001357A>G	uc002oit.2	+	60	9188	c.9058A>G	c.(9058-9060)ACT>GCT	p.T3020A	RYR1_uc002oiu.2_Missense_Mutation_p.T3020A|RYR1_uc002oiv.1_5'UTR|RYR1_uc010xuf.1_5'Flank	NM_000540	NP_000531	P21817	RYR1_HUMAN	skeletal muscle ryanodine receptor isoform 1	3020	Cytoplasmic.				muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(7)|pancreas(2)|breast(1)|central_nervous_system(1)|skin(1)	12	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	TTTCTTGTCCACTCCGGCTAA	0.582			NA											32	175					0	0	0.004289	0	0
TGFB1	7040	broad.mit.edu	37	19	41854260	41854260	+	Silent	SNP	C	C	T			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr19:41854260C>T	uc002oqh.1	-	2	1323	c.456G>A	c.(454-456)CGG>CGA	p.R152R	CYP2F1_uc010xvw.1_Intron|TMEM91_uc002oqi.2_5'Flank	NM_000660	NP_000651	P01137	TGFB1_HUMAN	transforming growth factor, beta 1 precursor	152					active induction of host immune response by virus|ATP biosynthetic process|cell cycle arrest|cell growth|cell-cell junction organization|chondrocyte differentiation|connective tissue replacement involved in inflammatory response wound healing|epidermal growth factor receptor signaling pathway|evasion of host defenses by virus|hemopoietic progenitor cell differentiation|induction of apoptosis|lymph node development|mitotic cell cycle G1/S transition checkpoint|negative regulation of blood vessel endothelial cell migration|negative regulation of cell growth|negative regulation of cell-cell adhesion|negative regulation of DNA replication|negative regulation of epithelial cell proliferation|negative regulation of fat cell differentiation|negative regulation of macrophage cytokine production|negative regulation of mitotic cell cycle|negative regulation of protein phosphorylation|ossification involved in bone remodeling|pathway-restricted SMAD protein phosphorylation|platelet activation|platelet degranulation|positive regulation of blood vessel endothelial cell migration|positive regulation of bone mineralization|positive regulation of cell division|positive regulation of chemotaxis|positive regulation of collagen biosynthetic process|positive regulation of epithelial to mesenchymal transition|positive regulation of fibroblast migration|positive regulation of interleukin-17 production|positive regulation of isotype switching to IgA isotypes|positive regulation of MAP kinase activity|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of peptidyl-serine phosphorylation|positive regulation of peptidyl-threonine phosphorylation|positive regulation of phosphatidylinositol 3-kinase activity|positive regulation of protein dephosphorylation|positive regulation of protein kinase B signaling cascade|positive regulation of protein secretion|positive regulation of SMAD protein import into nucleus|protein export from nucleus|protein import into nucleus, translocation|receptor catabolic process|regulation of DNA binding|regulation of striated muscle tissue development|regulation of transforming growth factor beta receptor signaling pathway|response to cholesterol|response to estradiol stimulus|response to progesterone stimulus|salivary gland morphogenesis|SMAD protein complex assembly|SMAD protein import into nucleus|transforming growth factor beta receptor signaling pathway|viral infectious cycle	extracellular space|Golgi lumen|nucleus|platelet alpha granule lumen|proteinaceous extracellular matrix	growth factor activity|type II transforming growth factor beta receptor binding				0					Hyaluronidase(DB00070)	GCAGCTCTGCCCGGGAGAGCA	0.522			NA											15	169					0	0	0.003163	0	0
PSG5	5673	broad.mit.edu	37	19	43679369	43679369	+	Missense_Mutation	SNP	G	G	C			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr19:43679369G>C	uc002ovu.2	-	4	1093	c.962C>G	c.(961-963)TCT>TGT	p.S321C	PSG6_uc010xwk.1_Intron|PSG5_uc010eir.2_Missense_Mutation_p.S196C|PSG5_uc002ovx.2_Missense_Mutation_p.S321C|PSG5_uc002ovv.2_Missense_Mutation_p.S414C|PSG5_uc002ovw.2_Intron	NM_002781	NP_002772	Q15238	PSG5_HUMAN	pregnancy specific beta-1-glycoprotein 5	321					female pregnancy	extracellular region				skin(3)	3		Prostate(69;0.00899)				CCACTTACCAGAGACTTCGAC	0.453			NA											38	355					0	0	0.00361	0	0
PSG4	5672	broad.mit.edu	37	19	43702175	43702175	+	Missense_Mutation	SNP	C	C	A			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr19:43702175C>A	uc002ovy.2	-	3	785	c.683G>T	c.(682-684)AGT>ATT	p.S228I	PSG6_uc010xwk.1_Missense_Mutation_p.S67I|PSG4_uc002owa.2_RNA|PSG4_uc002owb.2_Intron|PSG4_uc002ovz.2_Missense_Mutation_p.S228I	NM_002780	NP_002771	Q00888	PSG4_HUMAN	pregnancy specific beta-1-glycoprotein 4 isoform	228	Ig-like C2-type 1.				defense response|female pregnancy	extracellular region				ovary(1)	1		Prostate(69;0.00682)				GACTGGGTCACTGCGGCTGGC	0.517			NA											111	276					1.11784e-71	1.92895e-71	0.00361	1	0
APOE	348	broad.mit.edu	37	19	45412464	45412465	+	Missense_Mutation	DNP	CC	CC	AA			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr19:45412464_45412465CC>AA	uc002pab.2	+	4	994_995	c.911_912CC>AA	c.(910-912)GCC>GAA	p.A304E		NM_000041	NP_000032	P02649	APOE_HUMAN	apolipoprotein E precursor	304					anti-apoptosis|Cdc42 protein signal transduction|cell death|cGMP-mediated signaling|cholesterol efflux|cholesterol homeostasis|chylomicron remnant clearance|cytoskeleton organization|G-protein coupled receptor protein signaling pathway|high-density lipoprotein particle assembly|high-density lipoprotein particle clearance|high-density lipoprotein particle remodeling|induction of apoptosis|intracellular transport|negative regulation of blood vessel endothelial cell migration|negative regulation of cholesterol biosynthetic process|negative regulation of endothelial cell proliferation|negative regulation of MAP kinase activity|negative regulation of platelet activation|nitric oxide mediated signal transduction|phospholipid efflux|positive regulation of cGMP biosynthetic process|positive regulation of cholesterol efflux|positive regulation of cholesterol esterification|positive regulation of low-density lipoprotein particle receptor catabolic process|positive regulation of membrane protein ectodomain proteolysis|positive regulation of nitric-oxide synthase activity|receptor-mediated endocytosis|regulation of axon extension|regulation of neuronal synaptic plasticity|response to reactive oxygen species|reverse cholesterol transport|synaptic transmission, cholinergic|triglyceride metabolic process|very-low-density lipoprotein particle clearance|very-low-density lipoprotein particle remodeling	chylomicron|dendrite|high-density lipoprotein particle|intermediate-density lipoprotein particle|low-density lipoprotein particle|neuronal cell body|very-low-density lipoprotein particle	antioxidant activity|beta-amyloid binding|heparin binding|low-density lipoprotein particle receptor binding|metal chelating activity|phosphatidylcholine-sterol O-acyltransferase activator activity|phospholipid binding|protein heterodimerization activity|protein homodimerization activity|tau protein binding|very-low-density lipoprotein particle receptor binding				0	Lung NSC(12;0.0018)|all_lung(12;0.00481)	Ovarian(192;0.0728)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.00327)|Epithelial(262;0.174)	Human Serum Albumin(DB00062)|Serum albumin iodonated(DB00064)	GTGCAGGCTGCCGTGGGCACCA	0.708			NA											5	15					0	0	0.004672	0	0
APOC2	344	broad.mit.edu	37	19	45452505	45452505	+	Nonstop_Mutation	SNP	A	A	T			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr19:45452505A>T	uc002pah.2	+	4	408	c.305A>T	c.(304-306)TAA>TTA	p.*102L		NM_000483	NP_000474	P02655	APOC2_HUMAN	apolipoprotein C-II precursor	102					cholesterol efflux|chylomicron remnant clearance|high-density lipoprotein particle clearance|lipid catabolic process|lipoprotein metabolic process|negative regulation of cholesterol transport|negative regulation of lipid metabolic process|negative regulation of receptor-mediated endocytosis|negative regulation of very-low-density lipoprotein particle clearance|phospholipid efflux|positive regulation of fatty acid biosynthetic process|positive regulation of lipoprotein lipase activity|positive regulation of phospholipase activity|positive regulation of phospholipid catabolic process|positive regulation of triglyceride catabolic process|triglyceride homeostasis|very-low-density lipoprotein particle remodeling	chylomicron|intermediate-density lipoprotein particle|low-density lipoprotein particle|spherical high-density lipoprotein particle|very-low-density lipoprotein particle	lipase inhibitor activity|lipid binding|lipoprotein lipase activator activity|phospholipase activator activity|phospholipase binding|protein homodimerization activity			kidney(1)	1	Lung NSC(12;0.00858)|all_lung(12;0.0197)	Ovarian(192;0.0728)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.00327)|Epithelial(262;0.174)		GGAGAGGAGTAACAGCCAGAC	0.542			NA											7	30					0	0	0.00308	0	0
CCDC61	729440	broad.mit.edu	37	19	46519634	46519634	+	Missense_Mutation	SNP	G	G	C			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr19:46519634G>C	uc002pdw.2	+	10	1131	c.1131G>C	c.(1129-1131)CAG>CAC	p.Q377H	MIR769_hsa-mir-769|MI0003834_5'Flank	NM_001080402	NP_001073871			coiled-coil domain containing 61											ovary(1)	1		all_neural(266;0.113)|Ovarian(192;0.127)		OV - Ovarian serous cystadenocarcinoma(262;0.00221)|GBM - Glioblastoma multiforme(486;0.0233)|Epithelial(262;0.164)		AAAGGAAGCAGAGAGAGATCC	0.657			NA											3	31					0	0	0.000248	0	0
PLEKHA4	57664	broad.mit.edu	37	19	49351253	49351253	+	Silent	SNP	C	C	A	rs148488396		TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr19:49351253C>A	uc002pkx.2	-	14	2021	c.1470G>T	c.(1468-1470)ACG>ACT	p.T490T	PLEKHA4_uc002pkw.1_Silent_p.T5T|PLEKHA4_uc010eml.2_Silent_p.T465T	NM_020904	NP_065955	Q9H4M7	PKHA4_HUMAN	pleckstrin homology domain containing family A	490						cytoplasm|membrane	1-phosphatidylinositol binding			ovary(1)|central_nervous_system(1)|skin(1)	3		all_lung(116;4.89e-05)|Lung NSC(112;8.3e-05)|all_epithelial(76;0.000108)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.00027)|all cancers(93;0.00084)|GBM - Glioblastoma multiforme(486;0.0244)|Epithelial(262;0.0364)		GACCTGCCAGCGTGTCTTCCA	0.587			NA											5	28					0.000602214	0.000713082	0.000602	1	0
CPT1C	126129	broad.mit.edu	37	19	50204052	50204052	+	Silent	SNP	C	C	G			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr19:50204052C>G	uc002ppj.2	+	4	598	c.393C>G	c.(391-393)TCC>TCG	p.S131S	CPT1C_uc002ppl.3_Silent_p.S131S|CPT1C_uc002ppi.2_Silent_p.S48S|CPT1C_uc002ppk.2_Silent_p.S131S|CPT1C_uc010eng.2_Silent_p.S131S|CPT1C_uc010enh.2_Silent_p.S131S|CPT1C_uc010ybc.1_Intron	NM_152359	NP_689572	Q8TCG5	CPT1C_HUMAN	carnitine palmitoyltransferase 1C isoform 2	131	Cytoplasmic (Potential).				fatty acid metabolic process	integral to membrane|mitochondrial outer membrane	carnitine O-palmitoyltransferase activity			ovary(1)|central_nervous_system(1)|pancreas(1)	3		all_lung(116;1.05e-05)|Lung NSC(112;3.77e-05)|all_neural(266;0.107)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.0011)|GBM - Glioblastoma multiforme(134;0.00786)		TGCTTCTGTCCTACCACGGCT	0.657			NA											16	112					0	0	0.006122	0	0
SIGLEC12	89858	broad.mit.edu	37	19	52000183	52000183	+	Missense_Mutation	SNP	C	C	T			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr19:52000183C>T	uc002pwx.1	-	7	1606	c.1550G>A	c.(1549-1551)GGG>GAG	p.G517E	SIGLEC12_uc002pww.1_Missense_Mutation_p.G399E|SIGLEC12_uc010eoy.1_Missense_Mutation_p.G244E	NM_053003	NP_443729	Q96PQ1	SIG12_HUMAN	sialic acid binding immunoglobulin-like	517	Cytoplasmic (Potential).				cell adhesion	integral to membrane	sugar binding			ovary(3)|skin(2)	5		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.00161)|OV - Ovarian serous cystadenocarcinoma(262;0.0102)		GCCTGTATCCCCCACGCCCAC	0.592			NA											6	83					0	0	0.006214	0	0
FPR2	2358	broad.mit.edu	37	19	52272055	52272055	+	Missense_Mutation	SNP	C	C	G			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr19:52272055C>G	uc002pxr.2	+	2	189	c.144C>G	c.(142-144)ATC>ATG	p.I48M	FPR2_uc002pxs.3_Missense_Mutation_p.I48M|FPR2_uc010epf.2_Missense_Mutation_p.I48M	NM_001005738	NP_001005738	P25090	FPR2_HUMAN	formyl peptide receptor-like 1	48	Helical; Name=1; (Potential).				cell adhesion|cellular component movement|chemotaxis|inflammatory response	integral to membrane|plasma membrane	N-formyl peptide receptor activity			lung(3)|ovary(1)	4						GGCTTGTGATCTGGGTGGCTG	0.557			NA											15	88					0	0	0.004007	0	0
ZNF649	65251	broad.mit.edu	37	19	52394602	52394602	+	Missense_Mutation	SNP	C	C	A			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr19:52394602C>A	uc002pxy.2	-	5	1055	c.787G>T	c.(787-789)GGG>TGG	p.G263W	ZNF577_uc010ydf.1_5'Flank	NM_023074	NP_075562	Q9BS31	ZN649_HUMAN	zinc finger protein 649	263	C2H2-type 4.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|central_nervous_system(1)|skin(1)	3		all_neural(266;0.0602)		GBM - Glioblastoma multiforme(134;0.00152)|OV - Ovarian serous cystadenocarcinoma(262;0.0185)		TCACTGCACCCGTATGGTTTC	0.502			NA											21	93					1.87028e-06	2.50848e-06	0.001882	1	0
ZNF415	55786	broad.mit.edu	37	19	53612605	53612605	+	Missense_Mutation	SNP	C	C	A			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr19:53612605C>A	uc002qax.2	-	7	1186	c.837G>T	c.(835-837)ATG>ATT	p.M279I	ZNF415_uc002qat.2_Missense_Mutation_p.M243I|ZNF415_uc002qaw.2_Missense_Mutation_p.M231I|ZNF415_uc010yds.1_Missense_Mutation_p.M231I|ZNF415_uc010ydt.1_Missense_Mutation_p.M231I|ZNF415_uc002qau.2_Missense_Mutation_p.M218I|ZNF415_uc002qav.2_Missense_Mutation_p.M243I|ZNF415_uc002qba.2_Missense_Mutation_p.M1I|ZNF415_uc002qay.2_Missense_Mutation_p.M218I|ZNF415_uc002qaz.2_Missense_Mutation_p.M279I	NR_028343		Q09FC8	ZN415_HUMAN	RecName: Full=Zinc finger protein 415;	279	C2H2-type 1; degenerate.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|microtubule cytoskeleton|nucleolus	DNA binding|zinc ion binding			ovary(1)	1				GBM - Glioblastoma multiforme(134;0.0191)		GACGTACAGTCATGTGTGAGC	0.403			NA											9	95					1.12685e-05	1.45284e-05	0.004482	1	0
LILRB1	10859	broad.mit.edu	37	19	55143933	55143933	+	Nonsense_Mutation	SNP	C	C	A			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr19:55143933C>A	uc002qgj.2	+	7	1020	c.680C>A	c.(679-681)TCA>TAA	p.S227*	LILRB1_uc010erp.1_Intron|LILRB1_uc002qgl.2_Nonsense_Mutation_p.S227*|LILRB1_uc002qgk.2_Nonsense_Mutation_p.S227*|LILRB1_uc002qgm.2_Nonsense_Mutation_p.S227*|LILRB1_uc010erq.2_Nonsense_Mutation_p.S227*|LILRB1_uc010err.2_RNA	NM_006669	NP_006660	Q8NHL6	LIRB1_HUMAN	leukocyte immunoglobulin-like receptor,	227	Ig-like C2-type 3.|Extracellular (Potential).				regulation of immune response|response to virus	integral to membrane|plasma membrane	protein phosphatase 1 binding|receptor activity			large_intestine(1)|ovary(1)|skin(1)	3				GBM - Glioblastoma multiforme(193;0.0188)		AAGAAGCCATCACTCTCAGTG	0.552			NA								HNSCC(37;0.09)			13	85					2.61681e-11	4.04677e-11	0.00245	1	0
LILRB4	11006	broad.mit.edu	37	19	55179365	55179365	+	Silent	SNP	G	G	A			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr19:55179365G>A	uc002qgp.2	+	12	1604	c.1242G>A	c.(1240-1242)CAG>CAA	p.Q414Q	LILRB4_uc002qgq.2_Silent_p.Q413Q|LILRB4_uc002qgr.2_Silent_p.Q456Q|LILRB4_uc010ert.2_Silent_p.Q455Q|LILRB4_uc010eru.2_Silent_p.Q444Q	NM_006847	NP_006838	Q8NHJ6	LIRB4_HUMAN	leukocyte immunoglobulin-like receptor,	414	Cytoplasmic (Potential).|ITIM motif 2.					integral to membrane|plasma membrane	antigen binding|receptor activity			ovary(3)	3				GBM - Glioblastoma multiforme(193;0.035)		CCTACGCCCAGCTGCACAGCT	0.647			NA											14	80					0	0	0.00245	0	0
NLRP2	55655	broad.mit.edu	37	19	55493713	55493713	+	Missense_Mutation	SNP	G	G	T			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr19:55493713G>T	uc002qij.2	+	6	733	c.647G>T	c.(646-648)GGC>GTC	p.G216V	NLRP2_uc010yfp.1_Missense_Mutation_p.G193V|NLRP2_uc010esn.2_Missense_Mutation_p.G192V|NLRP2_uc010eso.2_Missense_Mutation_p.G213V|NLRP2_uc010esp.2_Missense_Mutation_p.G194V	NM_017852	NP_060322	Q9NX02	NALP2_HUMAN	NLR family, pyrin domain containing 2	216	NACHT.|ATP (Potential).				apoptosis|positive regulation of caspase activity|positive regulation of interleukin-1 beta secretion	cytoplasm	ATP binding|Pyrin domain binding			ovary(1)|skin(1)	2			BRCA - Breast invasive adenocarcinoma(297;0.163)	GBM - Glioblastoma multiforme(193;0.028)		GGTCCTGCAGGCCTTGGGAAA	0.537			NA											11	78					3.86212e-05	4.81489e-05	0.008291	1	0
PEG3	5178	broad.mit.edu	37	19	57327815	57327815	+	Silent	SNP	G	G	T			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr19:57327815G>T	uc002qnu.2	-	7	2346	c.1995C>A	c.(1993-1995)ACC>ACA	p.T665T	ZIM2_uc010ygq.1_Intron|ZIM2_uc010ygr.1_Intron|ZIM2_uc002qnr.2_Intron|ZIM2_uc002qnq.2_Intron|ZIM2_uc010etp.2_Intron|ZIM2_uc010ygs.1_Intron|PEG3_uc002qnt.2_Silent_p.T636T|PEG3_uc002qnv.2_Silent_p.T665T|PEG3_uc002qnw.2_Silent_p.T541T|PEG3_uc002qnx.2_Silent_p.T539T|PEG3_uc010etr.2_Silent_p.T665T	NM_001146186	NP_001139658	Q9GZU2	PEG3_HUMAN	paternally expressed 3 isoform 1	665					apoptosis|viral reproduction	cytoplasm|nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0269)		CAGGAATAAAGGTTTCCTCAC	0.443			NA											27	177					6.38683e-12	1.00415e-11	0.008361	1	0
ZSCAN1	284312	broad.mit.edu	37	19	58551840	58551840	+	Silent	SNP	C	C	T			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr19:58551840C>T	uc002qrc.1	+	4	640	c.393C>T	c.(391-393)GTC>GTT	p.V131V		NM_182572	NP_872378	Q8NBB4	ZSCA1_HUMAN	zinc finger and SCAN domain containing 1	131					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2		Colorectal(82;5.46e-05)|all_neural(62;0.0182)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0152)		TGGACTCGGTCGAACCCCAGG	0.612			NA											25	132					0	0	0.001786	0	0
KIDINS220	57498	broad.mit.edu	37	2	8919884	8919884	+	Nonsense_Mutation	SNP	G	G	A			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr2:8919884G>A	uc002qzc.2	-	18	2472	c.2290C>T	c.(2290-2292)CAG>TAG	p.Q764*	KIDINS220_uc010yiv.1_Nonsense_Mutation_p.Q530*|KIDINS220_uc002qzd.2_Nonsense_Mutation_p.Q722*|KIDINS220_uc010yiw.1_Nonsense_Mutation_p.Q765*	NM_020738	NP_065789	Q9ULH0	KDIS_HUMAN	kinase D-interacting substrate of 220 kDa	764	KAP NTPase.|Cytoplasmic (Potential).				activation of MAPKK activity|nerve growth factor receptor signaling pathway	cytosol|integral to membrane				ovary(3)|central_nervous_system(1)	4	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)					GTCTGATTCTGAGTGAAGCTG	0.458			NA											12	49					0	0	0.000978	0	0
C2orf39	92749	broad.mit.edu	37	2	26663341	26663341	+	Silent	SNP	A	A	G			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr2:26663341A>G	uc002rhg.2	+	8	1058	c.984A>G	c.(982-984)GAA>GAG	p.E328E	C2orf39_uc010eym.1_Intron	NM_145038	NP_659475	Q96MC2	CC164_HUMAN	hypothetical protein LOC92749	328	Potential.										0	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					AGAGAGATGAAGAAAGCACAG	0.428			NA											5	52					0	0	0.000602	0	0
FAM179A	165186	broad.mit.edu	37	2	29222107	29222107	+	Missense_Mutation	SNP	G	G	T			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr2:29222107G>T	uc010ezl.2	+	4	551	c.200G>T	c.(199-201)CGT>CTT	p.R67L	FAM179A_uc010ymm.1_Missense_Mutation_p.R67L	NM_199280	NP_954974	Q6ZUX3	F179A_HUMAN	hypothetical protein LOC165186	67							binding			ovary(3)|skin(1)	4						CAGCTCCTGCGTGGACTCGGA	0.617			NA											3	20					6.4e-05	7.91091e-05	0.004672	1	0
RASGRP3	25780	broad.mit.edu	37	2	33783856	33783856	+	Missense_Mutation	SNP	C	C	A			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr2:33783856C>A	uc002rox.2	+	18	2450	c.1823C>A	c.(1822-1824)GCC>GAC	p.A608D	RASGRP3_uc010ync.1_Missense_Mutation_p.A608D|RASGRP3_uc002roy.2_Missense_Mutation_p.A607D	NM_170672	NP_733772	Q8IV61	GRP3_HUMAN	RAS guanyl releasing protein 3 (calcium and	608					MAPKKK cascade|small GTPase mediated signal transduction	integral to plasma membrane|intracellular	calcium ion binding|diacylglycerol binding|guanyl-nucleotide exchange factor activity|protein binding|Rap GTPase activator activity|signal transducer activity			lung(3)|ovary(1)|pancreas(1)	5	all_hematologic(175;0.115)					CTACAGAGGGCCACCACCAGC	0.567			NA											7	81					0.00198382	0.0022822	0.001984	1	0
ATL2	64225	broad.mit.edu	37	2	38536571	38536571	+	Missense_Mutation	SNP	C	C	G			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr2:38536571C>G	uc002rqq.2	-	9	1051	c.1021G>C	c.(1021-1023)GAG>CAG	p.E341Q	ATL2_uc010ynm.1_Missense_Mutation_p.E323Q|ATL2_uc010ynn.1_Missense_Mutation_p.E323Q|ATL2_uc010yno.1_Missense_Mutation_p.E170Q|ATL2_uc002rqs.2_Missense_Mutation_p.E341Q|ATL2_uc002rqr.2_Missense_Mutation_p.E170Q	NM_001135673	NP_001129145	Q8NHH9	ATLA2_HUMAN	atlastin GTPase 2 isoform 2	341	Cytoplasmic.				endoplasmic reticulum organization|Golgi organization|protein homooligomerization	endoplasmic reticulum membrane|integral to membrane	GTP binding|GTPase activity|identical protein binding			ovary(1)|kidney(1)|skin(1)	3						CCACTTATCTCTTTTTCTACC	0.338			NA											4	76					0	0	0.000248	0	0
THADA	63892	broad.mit.edu	37	2	43819156	43819156	+	Missense_Mutation	SNP	C	C	A			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr2:43819156C>A	uc002rsw.3	-	3	458	c.106G>T	c.(106-108)GCT>TCT	p.A36S	THADA_uc002rsx.3_Missense_Mutation_p.A36S|THADA_uc002rsy.3_RNA|THADA_uc002rsz.2_5'UTR|THADA_uc002rta.2_5'UTR|THADA_uc002rtb.1_Missense_Mutation_p.A36S|THADA_uc002rtc.3_Missense_Mutation_p.A36S|THADA_uc002rtd.2_Missense_Mutation_p.A36S	NM_001083953	NP_001077422	Q6YHU6	THADA_HUMAN	thyroid adenoma associated	36							binding			ovary(2)|skin(1)	3		Acute lymphoblastic leukemia(82;0.00361)|all_hematologic(82;0.00837)				AGCAAAGAAGCTAGATTTTTC	0.328			NA											3	5					0.00024832	0.000299041	0.000248	1	0
ABCG5	64240	broad.mit.edu	37	2	44065079	44065079	+	Silent	SNP	G	G	T			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr2:44065079G>T	uc002rtn.2	-	2	299	c.159C>A	c.(157-159)CCC>CCA	p.P53P	ABCG5_uc002rto.2_Translation_Start_Site|ABCG5_uc002rtp.2_Translation_Start_Site|ABCG8_uc002rtq.2_5'Flank|ABCG8_uc010yoa.1_5'Flank	NM_022436	NP_071881	Q9H222	ABCG5_HUMAN	ATP-binding cassette sub-family G member 5	53	ABC transporter.|Cytoplasmic (Potential).				cholesterol efflux|cholesterol homeostasis|excretion|lipid metabolic process|negative regulation of intestinal cholesterol absorption|negative regulation of intestinal phytosterol absorption	apical plasma membrane|integral to membrane	ATP binding|ATPase activity|protein heterodimerization activity			ovary(1)|skin(1)	2		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)				TGTCCCACCAGGGCCTCACGC	0.587			NA											5	66					1.23904e-05	1.59024e-05	0.000602	1	0
ANTXR1	84168	broad.mit.edu	37	2	69271872	69271872	+	Splice_Site	SNP	A	A	T			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr2:69271872A>T	uc002sfg.2	+	3	581	c.225_splice	c.e3-2	p.S75_splice	ANTXR1_uc002sfe.2_Splice_Site_p.S75_splice|ANTXR1_uc002sff.2_Splice_Site_p.S75_splice|ANTXR1_uc002sfd.2_Splice_Site_p.S75_splice	NM_032208	NP_115584	Q9H6X2	ANTR1_HUMAN	anthrax toxin receptor 1 isoform 1 precursor						actin cytoskeleton reorganization|substrate adhesion-dependent cell spreading	filopodium membrane|integral to membrane|lamellipodium membrane	actin filament binding|collagen binding|metal ion binding|protein binding|transmembrane receptor activity			ovary(2)|skin(2)	4						TTTCCTTTCCAGCCCACAGTT	0.463			NA							Familial_Infantile_Hemangioma				4	67					0	0	0.001168	0	0
TACR1	6869	broad.mit.edu	37	2	75425737	75425737	+	Missense_Mutation	SNP	G	G	C			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr2:75425737G>C	uc002sng.2	-	1	909	c.324C>G	c.(322-324)CAC>CAG	p.H108Q	TACR1_uc002snh.2_Missense_Mutation_p.H108Q	NM_001058	NP_001049	P25103	NK1R_HUMAN	tachykinin receptor 1 isoform long	108	Helical; Name=3; (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|detection of abiotic stimulus|mechanosensory behavior	integral to plasma membrane	protein binding			ovary(1)	1					Aprepitant(DB00673)|Ketamine(DB01221)|Vapreotide(DB04894)	GAAAGAAGTTGTGGAACTTGC	0.512	Pancreas(64;62 1268 3653 14826 43765)		NA											12	56					0	0	0.000978	0	0
TRIM43	129868	broad.mit.edu	37	2	96259801	96259801	+	Missense_Mutation	SNP	G	G	C			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr2:96259801G>C	uc002suv.2	+	2	166	c.30G>C	c.(28-30)CAG>CAC	p.Q10H		NM_138800	NP_620155	Q96BQ3	TRI43_HUMAN	tripartite motif-containing 43	10						intracellular	zinc ion binding			ovary(1)	1						ATGCCTTCCAGAAGGAACTCA	0.483			NA											21	173					0	0	0.004656	0	0
SULT1C3	442038	broad.mit.edu	37	2	108875201	108875201	+	Missense_Mutation	SNP	T	T	A			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr2:108875201T>A	uc010ywo.1	+	5	538	c.538T>A	c.(538-540)TCC>ACC	p.S180T		NM_001008743	NP_001008743	Q6IMI6	ST1C3_HUMAN	sulfotransferase family, cytosolic, 1C, member	180						cytoplasm	alcohol sulfotransferase activity			skin(1)	1						TGTTGGCGGGTCCTGGTTTGA	0.453			NA											5	72					0	0	0.000602	0	0
RANBP2	5903	broad.mit.edu	37	2	109381205	109381205	+	Missense_Mutation	SNP	G	G	T			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr2:109381205G>T	uc002tem.3	+	20	4336	c.4210G>T	c.(4210-4212)GTT>TTT	p.V1404F		NM_006267	NP_006258	P49792	RBP2_HUMAN	RAN binding protein 2	1404					carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA transport|protein folding|protein import into nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear pore	peptidyl-prolyl cis-trans isomerase activity|Ran GTPase binding|zinc ion binding		RANBP2/ALK(16)	soft_tissue(16)|lung(1)|pancreas(1)	18						CCCAGAGAATGTTCAAGATCG	0.398			NA											9	76					0.000978159	0.00114863	0.000978	1	0
BCL2L11	10018	broad.mit.edu	37	2	111881467	111881467	+	Missense_Mutation	SNP	G	G	C			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr2:111881467G>C	uc002tgv.1	+	2	433	c.145G>C	c.(145-147)GGA>CGA	p.G49R	BCL2L11_uc002tgt.1_Intron|BCL2L11_uc002tgu.1_Intron|BCL2L11_uc002tgw.1_Intron|BCL2L11_uc002tgx.1_Intron|BCL2L11_uc010fkd.1_Intron|BCL2L11_uc002tgy.1_Intron|BCL2L11_uc002tgz.1_Intron|BCL2L11_uc010fke.1_Intron|BCL2L11_uc002tha.1_Missense_Mutation_p.G49R|BCL2L11_uc002thb.1_Intron|BCL2L11_uc002thc.1_Intron|BCL2L11_uc002thd.1_Intron	NM_138621	NP_619527	O43521	B2L11_HUMAN	BCL2-like 11 isoform 1	49					activation of pro-apoptotic gene products|induction of apoptosis by extracellular signals|induction of apoptosis by intracellular signals|nerve growth factor receptor signaling pathway|positive regulation of protein homooligomerization|positive regulation of release of cytochrome c from mitochondria	cytosol|endomembrane system|mitochondrial outer membrane|plasma membrane	protein binding|protein binding				0						AGGCAATCACGGAGGTGAAGG	0.632			NA											6	56					0	0	0.001168	0	0
CCDC74A	90557	broad.mit.edu	37	2	132289308	132289308	+	Missense_Mutation	SNP	C	C	A			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr2:132289308C>A	uc002tta.2	+	4	668	c.616C>A	c.(616-618)CTG>ATG	p.L206M	CCDC74A_uc002ttb.2_Missense_Mutation_p.L140M	NM_138770	NP_620125	Q96AQ1	CC74A_HUMAN	coiled-coil domain containing 74A	206										skin(1)	1						GAAGGCGGACCTGGAAGAGGA	0.582			NA											8	105					1.08611e-07	1.51041e-07	0.000978	1	0
LRP1B	53353	broad.mit.edu	37	2	141299393	141299393	+	Missense_Mutation	SNP	G	G	C			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr2:141299393G>C	uc002tvj.1	-	44	8314	c.7342C>G	c.(7342-7344)CAT>GAT	p.H2448D		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	2448	Extracellular (Potential).|LDL-receptor class B 27.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		ATTGGCTGATGTGGAATATCG	0.383	Colon(99;50 2074 2507 20106)		NA								TSP Lung(27;0.18)			12	132					0	0	0.001855	0	0
GCG	2641	broad.mit.edu	37	2	163004007	163004007	+	Missense_Mutation	SNP	T	T	G			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr2:163004007T>G	uc002ucc.2	-	3	209	c.110A>C	c.(109-111)CAG>CCG	p.Q37P		NM_002054	NP_002045	P01275	GLUC_HUMAN	glucagon preproprotein	37					cell proliferation|cellular response to glucagon stimulus|energy reserve metabolic process|feeding behavior|regulation of insulin secretion	plasma membrane|soluble fraction	hormone activity				0					Exenatide(DB01276)|Phentolamine(DB00692)	TGGGTCTGCCTGGGAAGCTGA	0.463			NA											19	252					0	0	0.008871	0	0
SCN1A	6323	broad.mit.edu	37	2	166908495	166908495	+	Missense_Mutation	SNP	A	A	G			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr2:166908495A>G	uc010zcz.1	-	6	716	c.698T>C	c.(697-699)CTG>CCG	p.L233P	SCN1A_uc002udo.3_Missense_Mutation_p.L102P|SCN1A_uc010fpk.2_Missense_Mutation_p.L102P	NM_006920	NP_008851	P35498	SCN1A_HUMAN	sodium channel, voltage-gated, type I, alpha	233	Helical; Voltage-sensor; Name=S4 of repeat I; (By similarity).|I.					voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|skin(6)|large_intestine(1)	13					Lamotrigine(DB00555)|Levetiracetam(DB01202)|Phenacemide(DB01121)|Phenytoin(DB00252)|Topiramate(DB00273)|Zonisamide(DB00909)	AATGGTTTTCAGGCCTGAAAG	0.378			NA											3	92					0	0	0.004672	0	0
HOXD10	3236	broad.mit.edu	37	2	176981700	176981700	+	Nonsense_Mutation	SNP	G	G	T			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr2:176981700G>T	uc002ukj.2	+	1	209	c.139G>T	c.(139-141)GGA>TGA	p.G47*		NM_002148	NP_002139	P28358	HXD10_HUMAN	homeobox D10	47						nucleus	sequence-specific DNA binding			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(117;0.0207)|Epithelial(96;0.18)	Colorectal(32;0.0226)|READ - Rectum adenocarcinoma(9;0.0556)		GGGGACCTATGGAATGCAAAC	0.478			NA											11	101					1.36491e-13	2.20726e-13	0.001855	1	0
CCDC141	285025	broad.mit.edu	37	2	179720986	179720986	+	Missense_Mutation	SNP	G	G	T			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr2:179720986G>T	uc002unf.1	-	8	1195	c.1138C>A	c.(1138-1140)CAG>AAG	p.Q380K		NM_173648	NP_775919	Q6ZP82	CC141_HUMAN	coiled-coil domain containing 141	380	Potential.						protein binding			ovary(7)|pancreas(2)|skin(1)	10			OV - Ovarian serous cystadenocarcinoma(117;0.0274)|Epithelial(96;0.0531)|all cancers(119;0.147)			CTTGTTACCTGCATTTTTTCA	0.299			NA											5	60					0.00116845	0.00135799	0.001168	1	0
ASNSD1	54529	broad.mit.edu	37	2	190532188	190532188	+	Silent	SNP	C	C	A			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr2:190532188C>A	uc002uqt.2	+	4	1764	c.1330C>A	c.(1330-1332)CGA>AGA	p.R444R		NM_019048	NP_061921	Q9NWL6	ASND1_HUMAN	asparagine synthetase domain containing 1	444	Asparagine synthetase.				asparagine biosynthetic process|glutamine metabolic process		asparagine synthase (glutamine-hydrolyzing) activity			ovary(2)|skin(1)	3			OV - Ovarian serous cystadenocarcinoma(117;0.00318)|Epithelial(96;0.0449)|all cancers(119;0.118)			AAGAAGAACTCGAATATGTCA	0.413			NA											5	99					3.59834e-05	4.51587e-05	0.001168	1	0
SF3B1	23451	broad.mit.edu	37	2	198274523	198274523	+	Missense_Mutation	SNP	C	C	T			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr2:198274523C>T	uc002uue.2	-	7	923	c.875G>A	c.(874-876)AGA>AAA	p.R292K		NM_012433	NP_036565	O75533	SF3B1_HUMAN	splicing factor 3b, subunit 1 isoform 1	292	Interaction with PPP1R8.				nuclear mRNA splicing, via spliceosome	catalytic step 2 spliceosome|nuclear speck|U12-type spliceosomal complex	protein binding			pancreas(3)|ovary(1)|breast(1)|skin(1)	6			OV - Ovarian serous cystadenocarcinoma(117;0.246)			TTCATCCCATCTGTTTTTACG	0.512			NA											33	434					0	0	0.003271	0	0
TRAK2	66008	broad.mit.edu	37	2	202264117	202264117	+	Missense_Mutation	SNP	C	C	T			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr2:202264117C>T	uc002uyb.3	-	5	909	c.463G>A	c.(463-465)GGA>AGA	p.G155R	TRAK2_uc002uyc.2_Missense_Mutation_p.G155R	NM_015049	NP_055864	O60296	TRAK2_HUMAN	trafficking protein, kinesin binding 2	155	Potential.					early endosome|plasma membrane	GABA receptor binding				0						AAGGCTTGTCCCAATTGCTCC	0.418			NA											7	47					0	0	0.001984	0	0
RAPH1	65059	broad.mit.edu	37	2	204305195	204305195	+	Silent	SNP	G	G	A			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr2:204305195G>A	uc002vad.2	-	14	2943	c.2718C>T	c.(2716-2718)CCC>CCT	p.P906P		NM_213589	NP_998754	Q70E73	RAPH1_HUMAN	Ras association and pleckstrin homology domains	906					cell-matrix adhesion|signal transduction	cytoplasm|cytoskeleton|filopodium|lamellipodium|nucleus|plasma membrane				ovary(3)|breast(3)|central_nervous_system(2)|lung(1)|skin(1)	10						GGATGGAGCTGGGCTGCCACT	0.473			NA											13	106					0	0	0.001368	0	0
NDUFS1	4719	broad.mit.edu	37	2	206994878	206994878	+	Silent	SNP	G	G	A			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr2:206994878G>A	uc002vbe.2	-	15	1769	c.1642C>T	c.(1642-1644)CTG>TTG	p.L548L	NDUFS1_uc010ziq.1_Silent_p.L562L|NDUFS1_uc010zir.1_Silent_p.L512L|NDUFS1_uc010zis.1_Silent_p.L491L|NDUFS1_uc010zit.1_Silent_p.L437L|NDUFS1_uc010ziu.1_Silent_p.L432L	NM_005006	NP_004997	P28331	NDUS1_HUMAN	NADH dehydrogenase (ubiquinone) Fe-S protein 1,	548					apoptosis|ATP metabolic process|mitochondrial electron transport, NADH to ubiquinone|reactive oxygen species metabolic process|regulation of mitochondrial membrane potential|transport	mitochondrial intermembrane space|mitochondrial respiratory chain complex I	2 iron, 2 sulfur cluster binding|4 iron, 4 sulfur cluster binding|electron carrier activity|metal ion binding|NADH dehydrogenase (ubiquinone) activity|protein binding			ovary(1)	1					NADH(DB00157)	TCTGCTCCCAGGAGAAACAGC	0.458			NA											7	68					0	0	0.001984	0	0
ADAM23	8745	broad.mit.edu	37	2	207435496	207435496	+	Nonsense_Mutation	SNP	C	C	G			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr2:207435496C>G	uc002vbq.2	+	16	1750	c.1527C>G	c.(1525-1527)TAC>TAG	p.Y509*	ADAM23_uc010ziv.1_RNA	NM_003812	NP_003803	O75077	ADA23_HUMAN	ADAM metallopeptidase domain 23 preproprotein	509	Disintegrin.|Extracellular (Potential).				cell adhesion|central nervous system development|proteolysis	extracellular region|integral to plasma membrane	integrin binding|metalloendopeptidase activity|zinc ion binding			skin(2)|ovary(1)	3				LUSC - Lung squamous cell carcinoma(261;0.0961)|Lung(261;0.182)|Epithelial(149;0.205)		GAAATGGATACGTGGAAGCTG	0.413	Melanoma(194;1127 2130 19620 24042 27855)		NA											8	54					0	0	0.006214	0	0
GLB1L	79411	broad.mit.edu	37	2	220107620	220107620	+	Missense_Mutation	SNP	T	T	A			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr2:220107620T>A	uc002vkm.2	-	4	499	c.260A>T	c.(259-261)CAC>CTC	p.H87L	GLB1L_uc002vkk.2_5'Flank|GLB1L_uc010zkx.1_Missense_Mutation_p.H87L|GLB1L_uc002vkn.2_Missense_Mutation_p.H87L|STK16_uc002vko.2_5'Flank|STK16_uc002vks.2_5'Flank|STK16_uc010zky.1_5'Flank|STK16_uc010fwf.2_5'Flank|STK16_uc002vkp.2_5'Flank|STK16_uc002vkr.2_5'Flank|STK16_uc002vkq.2_5'Flank	NM_024506	NP_078782	Q6UWU2	GLB1L_HUMAN	galactosidase, beta 1-like precursor	87					carbohydrate metabolic process	extracellular region	cation binding|hydrolase activity, hydrolyzing O-glycosyl compounds				0		all_lung(227;1.19e-05)|Lung NSC(271;2.76e-05)|Medulloblastoma(418;0.0208)|Esophageal squamous(248;0.0559)		Epithelial(149;1.3e-11)|all cancers(144;2.07e-10)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		CTGTGGCTCGTGGTAGTTCCA	0.527			NA											5	55					0	0	0.000602	0	0
TRPM8	79054	broad.mit.edu	37	2	234894455	234894455	+	Missense_Mutation	SNP	T	T	G			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr2:234894455T>G	uc002vvh.2	+	21	2925	c.2885T>G	c.(2884-2886)ATC>AGC	p.I962S	TRPM8_uc010fyj.2_Missense_Mutation_p.I540S|TRPM8_uc010fyk.2_RNA	NM_024080	NP_076985	Q7Z2W7	TRPM8_HUMAN	transient receptor potential cation channel,	962	Helical; Name=6; (Potential).					integral to membrane				skin(4)	4		Breast(86;0.00205)|Renal(207;0.00694)|all_lung(227;0.0129)|Lung NSC(271;0.0408)|all_hematologic(139;0.0753)|Acute lymphoblastic leukemia(138;0.224)		Epithelial(121;1.19e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000139)|Lung(119;0.00758)|LUSC - Lung squamous cell carcinoma(224;0.0108)	Menthol(DB00825)	CTGGTGTGCATCTACATGTTA	0.557			NA											4	63					0	0	0.000248	0	0
COL6A3	1293	broad.mit.edu	37	2	238245036	238245036	+	Missense_Mutation	SNP	G	G	T			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr2:238245036G>T	uc002vwl.2	-	40	8992	c.8707C>A	c.(8707-8709)CCA>ACA	p.P2903T	COL6A3_uc002vwo.2_Missense_Mutation_p.P2697T|COL6A3_uc010znj.1_Missense_Mutation_p.P2296T|COL6A3_uc002vwj.2_Missense_Mutation_p.P284T	NM_004369	NP_004360	P12111	CO6A3_HUMAN	alpha 3 type VI collagen isoform 1 precursor	2903	Nonhelical region.				axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			ovary(8)|central_nervous_system(6)|skin(2)|upper_aerodigestive_tract(1)|pancreas(1)	18		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		TTCACAGATGGCTGATTTATA	0.572			NA											12	172					1.61879e-10	2.4368e-10	0.001368	1	0
DEFB127	140850	broad.mit.edu	37	20	138186	138186	+	Missense_Mutation	SNP	A	A	C			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr20:138186A>C	uc002wcy.1	+	1	1	c.1A>C	c.(1-3)ATG>CTG	p.M1L		NM_139074	NP_620713	Q9H1M4	DB127_HUMAN	defensin, beta 127 preproprotein	1					defense response to bacterium|innate immune response	extracellular region					0		all_cancers(10;7.65e-05)|Lung NSC(37;0.0417)|all_epithelial(17;0.0676)|all_lung(30;0.0713)|Breast(17;0.231)	OV - Ovarian serous cystadenocarcinoma(29;0.122)			AAGCCTGGCCATGGGGCTCTT	0.468			NA											3	89					0	0	0.004672	0	0
UBOX5	22888	broad.mit.edu	37	20	3102805	3102805	+	Missense_Mutation	SNP	C	C	A			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr20:3102805C>A	uc002whw.2	-	3	650	c.480G>T	c.(478-480)TGG>TGT	p.W160C	uc002whv.1_Intron|UBOX5_uc002whx.2_Missense_Mutation_p.W160C|UBOX5_uc002why.1_Missense_Mutation_p.W160C	NM_014948	NP_055763	O94941	RNF37_HUMAN	U-box domain containing 5 isoform a	160						nucleus|ubiquitin ligase complex	ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|skin(1)	2						CCCCTTTATTCCAGAGCTCCT	0.582			NA											13	62					1.61879e-10	2.4368e-10	0.001368	1	0
SPTLC3	55304	broad.mit.edu	37	20	13145412	13145412	+	Silent	SNP	T	T	G			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr20:13145412T>G	uc002wod.1	+	12	1846	c.1557T>G	c.(1555-1557)GCT>GCG	p.A519A		NM_018327	NP_060797	Q9NUV7	SPTC3_HUMAN	serine palmitoyltransferase, long chain base	519					sphingoid biosynthetic process	integral to membrane|serine C-palmitoyltransferase complex	pyridoxal phosphate binding|serine C-palmitoyltransferase activity|transferase activity, transferring nitrogenous groups				0					Pyridoxal Phosphate(DB00114)	TTTTAGAAGCTCTTGATGAAA	0.438			NA											3	20					0	0	0.004672	0	0
ESF1	51575	broad.mit.edu	37	20	13756763	13756763	+	Missense_Mutation	SNP	C	C	A			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr20:13756763C>A	uc002woj.2	-	3	899	c.791G>T	c.(790-792)AGA>ATA	p.R264I	ESF1_uc002wok.1_Missense_Mutation_p.R264I	NM_016649	NP_057733	Q9H501	ESF1_HUMAN	ABT1-associated protein	264					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus|nucleoplasm				ovary(1)	1						aCCTGAAGCTCTACCAACACT	0.234			NA											18	114					2.48551e-13	4.00797e-13	0.00499	1	0
BPIL1	80341	broad.mit.edu	37	20	31609550	31609550	+	Missense_Mutation	SNP	C	C	G			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr20:31609550C>G	uc002wyj.2	+	15	1474	c.1280C>G	c.(1279-1281)GCC>GGC	p.A427G		NM_025227	NP_079503	Q8N4F0	BPIL1_HUMAN	bactericidal/permeability-increasing	427						extracellular region	lipid binding			skin(2)|large_intestine(1)|ovary(1)	4						ATGGGAATTGCCCTCCCTGGT	0.468			NA											21	87					0	0	0.002299	0	0
TOP1	7150	broad.mit.edu	37	20	39746848	39746848	+	Missense_Mutation	SNP	G	G	A			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr20:39746848G>A	uc002xjl.2	+	18	2108	c.1862G>A	c.(1861-1863)CGT>CAT	p.R621H	uc002xjn.1_Intron	NM_003286	NP_003277	P11387	TOP1_HUMAN	DNA topoisomerase I	621					DNA topological change|interspecies interaction between organisms|phosphorylation|programmed cell death|response to drug	chromosome|nucleolus|nucleoplasm	ATP binding|chromatin DNA binding|DNA topoisomerase (ATP-hydrolyzing) activity|DNA topoisomerase type I activity|protein binding			breast(3)|ovary(2)|central_nervous_system(1)|kidney(1)	7		Myeloproliferative disorder(115;0.00878)			Irinotecan(DB00762)|Lucanthone(DB04967)|Topotecan(DB01030)	TCTTATAACCGTGCCAATCGA	0.423			NA	T	NUP98	AML*								9	41					0	0	0.004482	0	0
CHD6	84181	broad.mit.edu	37	20	40161981	40161981	+	Missense_Mutation	SNP	C	C	T			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr20:40161981C>T	uc002xka.1	-	3	440	c.262G>A	c.(262-264)GGA>AGA	p.G88R	CHD6_uc002xkd.2_Missense_Mutation_p.G66R|CHD6_uc002xkc.2_Missense_Mutation_p.G123R	NM_032221	NP_115597	Q8TD26	CHD6_HUMAN	chromodomain helicase DNA binding protein 6	88	Poly-Gly.				chromatin remodeling|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding			ovary(6)|skin(5)|lung(2)|central_nervous_system(1)	14		Myeloproliferative disorder(115;0.00425)				CCAGTACCTCCTCCTCCACTG	0.507			NA											11	138					0	0	0.008291	0	0
SERINC3	10955	broad.mit.edu	37	20	43142612	43142613	+	Missense_Mutation	DNP	CC	CC	AA			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr20:43142612_43142613CC>AA	uc002xme.2	-	2	242_243	c.108_109GG>TT	c.(106-111)ACGGTG>ACTTTG	p.V37L	SERINC3_uc002xmf.1_Missense_Mutation_p.V37L|SERINC3_uc010ggs.1_Missense_Mutation_p.V30L|SERINC3_uc010zwp.1_5'UTR	NM_198941	NP_945179	Q13530	SERC3_HUMAN	tumor differentially expressed protein 1	37	Extracellular (Potential).					integral to membrane|plasma membrane	protein binding			skin(3)	3		Myeloproliferative disorder(115;0.0122)	Colorectal(3;0.000291)|COAD - Colon adenocarcinoma(18;0.00189)			AGGCGAGTCACCGTGGAATTCT	0.47			NA											9	99					0	0	0.004672	0	0
ZNF335	63925	broad.mit.edu	37	20	44590736	44590736	+	Missense_Mutation	SNP	C	C	A			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr20:44590736C>A	uc002xqw.2	-	10	1742	c.1619G>T	c.(1618-1620)CGG>CTG	p.R540L	ZNF335_uc010zxk.1_Missense_Mutation_p.R385L	NM_022095	NP_071378	Q9H4Z2	ZN335_HUMAN	zinc finger protein 335	540	C2H2-type 4.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(3)|ovary(1)	4		Myeloproliferative disorder(115;0.0122)				AGCGGCGTGCCGAATGACGTC	0.627			NA											13	65					9.31168e-06	1.20604e-05	0.001855	1	0
PSMA7	5688	broad.mit.edu	37	20	60715998	60715998	+	Silent	SNP	A	A	T			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr20:60715998A>T	uc002ybx.1	-	2	214	c.99T>A	c.(97-99)GTT>GTA	p.V33V	PSMA7_uc002yby.1_RNA|SS18L1_uc011aaa.1_5'Flank|SS18L1_uc002ybz.1_5'Flank|SS18L1_uc002yca.1_5'Flank|SS18L1_uc002ycb.2_5'Flank	NM_002792	NP_002783	O14818	PSA7_HUMAN	proteasome alpha 7 subunit	33					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|interspecies interaction between organisms|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	cytoplasm|nucleus|proteasome core complex, alpha-subunit complex	identical protein binding|threonine-type endopeptidase activity				0	Breast(26;3.97e-09)		BRCA - Breast invasive adenocarcinoma(19;1.28e-07)			CTCGAACACCAACCTTTAATT	0.313			NA											5	90					0	0	0.001168	0	0
OSBPL2	9885	broad.mit.edu	37	20	60864347	60864347	+	Silent	SNP	C	C	T			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr20:60864347C>T	uc002yck.1	+	12	1412	c.1210C>T	c.(1210-1212)CTG>TTG	p.L404L	OSBPL2_uc002ycl.1_Silent_p.L392L|OSBPL2_uc011aah.1_Intron	NM_144498	NP_653081	Q9H1P3	OSBL2_HUMAN	oxysterol-binding protein-like protein 2 isoform	404					lipid transport		lipid binding			ovary(1)|central_nervous_system(1)	2	Breast(26;7.76e-09)		BRCA - Breast invasive adenocarcinoma(19;1.33e-06)			GGACTGCCGCCTGCGCCCTGA	0.607			NA											3	19					0	0	0.000248	0	0
C20orf166	128826	broad.mit.edu	37	20	61167750	61167750	+	Missense_Mutation	SNP	C	C	A			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr20:61167750C>A	uc011aaj.1	+	4	999	c.220C>A	c.(220-222)CCC>ACC	p.P74T		NM_178463	NP_848558	Q9H1L0	CT166_HUMAN	hypothetical protein LOC128826	74											0	Breast(26;1.04e-08)		BRCA - Breast invasive adenocarcinoma(19;7.17e-06)			TCAGCCCCAGCCCCACAGTGC	0.522			NA											13	53					7.03913e-09	1.02158e-08	0.001368	1	0
ZNF512B	57473	broad.mit.edu	37	20	62592741	62592741	+	Missense_Mutation	SNP	T	T	G			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr20:62592741T>G	uc002yhl.1	-	16	2402	c.2348A>C	c.(2347-2349)AAG>ACG	p.K783T		NM_020713	NP_065764	Q96KM6	Z512B_HUMAN	zinc finger protein 512B	783					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_cancers(38;2.14e-11)|all_epithelial(29;3.41e-13)|Lung NSC(23;3.41e-09)|all_lung(23;1.06e-08)					ACAGCGGTACTTCCCTGCCAG	0.602			NA											4	63					0	0	0.000248	0	0
JAM2	58494	broad.mit.edu	37	21	27066137	27066137	+	Missense_Mutation	SNP	C	C	T			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr21:27066137C>T	uc002ylp.1	+	4	856	c.311C>T	c.(310-312)GCG>GTG	p.A104V	JAM2_uc011ace.1_Missense_Mutation_p.A104V|JAM2_uc002ylq.1_RNA|JAM2_uc011acf.1_Missense_Mutation_p.A68V|JAM2_uc010glh.1_RNA|JAM2_uc002ylr.1_Missense_Mutation_p.A104V|JAM2_uc010gli.1_Missense_Mutation_p.A104V	NM_021219	NP_067042	P57087	JAM2_HUMAN	junctional adhesion molecule 2 precursor	104	Ig-like V-type.|Extracellular (Potential).				blood coagulation|cell-cell adhesion|leukocyte migration	integral to plasma membrane|tight junction					0						AGAAGTGATGCGGGGAAATAT	0.388			NA											14	96					0	0	0.001855	0	0
ADAMTS1	9510	broad.mit.edu	37	21	28212681	28212681	+	Missense_Mutation	SNP	G	G	C			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr21:28212681G>C	uc002ymf.2	-	5	2034	c.1579C>G	c.(1579-1581)CCG>GCG	p.P527A		NM_006988	NP_008919	Q9UHI8	ATS1_HUMAN	ADAM metallopeptidase with thrombospondin type 1	527	Disintegrin.				integrin-mediated signaling pathway|negative regulation of cell proliferation|proteolysis		heparin binding|zinc ion binding			lung(3)|large_intestine(2)|central_nervous_system(1)	6		Breast(209;0.000962)		Lung(58;0.215)		TCCGCCCACGGGAAGTGTTTG	0.532			NA											4	45					0	0	0.000248	0	0
CLDN8	9073	broad.mit.edu	37	21	31587816	31587816	+	Missense_Mutation	SNP	G	G	T			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr21:31587816G>T	uc002ynu.1	-	1	503	c.428C>A	c.(427-429)GCC>GAC	p.A143D		NM_199328	NP_955360	P56748	CLD8_HUMAN	claudin 8	143	Extracellular (Potential).				calcium-independent cell-cell adhesion	endoplasmic reticulum|integral to membrane|tight junction	identical protein binding|structural molecule activity				0						TCTGATGATGGCATTGGCAAC	0.488			NA											5	22					1.26484e-09	1.86433e-09	0.00308	1	0
KRTAP19-7	337974	broad.mit.edu	37	21	31933420	31933420	+	Silent	SNP	A	A	G			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr21:31933420A>G	uc011adb.1	-	1	189	c.189T>C	c.(187-189)TAT>TAC	p.Y63Y		NM_181614	NP_853645	Q3SYF9	KR197_HUMAN	keratin associated protein 19-7	63						intermediate filament					0						TATTTATTCAATAGAATCCAG	0.423			NA											10	179					0	0	0.008291	0	0
KRTAP8-1	337879	broad.mit.edu	37	21	32185435	32185435	+	Missense_Mutation	SNP	T	T	A			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr21:32185435T>A	uc002you.2	-	1	136	c.104A>T	c.(103-105)TAC>TTC	p.Y35F		NM_175857	NP_787053	Q8IUC2	KRA81_HUMAN	keratin associated protein 8-1	35	12 X 2 AA repeats of G-[YCGS].					intermediate filament					0						CACTGGAGAGTAGGTGCTGCC	0.572			NA											14	45					0	0	0.001855	0	0
ITSN1	6453	broad.mit.edu	37	21	35183319	35183319	+	Missense_Mutation	SNP	G	G	C			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr21:35183319G>C	uc002yta.1	+	21	2628	c.2360G>C	c.(2359-2361)GGA>GCA	p.G787A	DONSON_uc002ysn.1_Intron|ITSN1_uc002yth.3_RNA|ITSN1_uc002ysz.2_Missense_Mutation_p.G782A|ITSN1_uc010gmg.2_Missense_Mutation_p.G745A|ITSN1_uc010gmh.2_RNA|ITSN1_uc002ysw.2_Missense_Mutation_p.G787A|ITSN1_uc010gmi.2_Missense_Mutation_p.G750A|ITSN1_uc010gmj.2_Missense_Mutation_p.G666A|ITSN1_uc002ysy.2_Missense_Mutation_p.G782A|ITSN1_uc002ysx.2_Missense_Mutation_p.G745A|ITSN1_uc002ytb.1_Missense_Mutation_p.G782A|ITSN1_uc002ytc.1_Missense_Mutation_p.G782A|ITSN1_uc002ytd.2_RNA|ITSN1_uc010gmk.2_Missense_Mutation_p.G750A|ITSN1_uc010gml.2_RNA|ITSN1_uc002ytj.2_Missense_Mutation_p.G782A|ITSN1_uc010gmm.1_RNA|ITSN1_uc002yte.2_Missense_Mutation_p.G721A|ITSN1_uc002ytf.1_RNA	NM_003024	NP_003015	Q15811	ITSN1_HUMAN	intersectin 1 isoform ITSN-l	787	SH3 1.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|synaptic vesicle endocytosis	cell junction|coated pit|cytosol|lamellipodium|synapse|synaptosome	calcium ion binding|proline-rich region binding|protein complex scaffold|Rho guanyl-nucleotide exchange factor activity			ovary(3)|skin(1)	4						TGGCTTGGAGGAGAATTAAAA	0.463			NA											49	140					0	0	0.00361	0	0
PSMG1	8624	broad.mit.edu	37	21	40550484	40550484	+	Silent	SNP	G	G	A			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr21:40550484G>A	uc002yxi.2	-	5	675	c.546C>T	c.(544-546)GGC>GGT	p.G182G	PSMG1_uc002yxj.2_Silent_p.G161G|PSMG1_uc010gob.2_Silent_p.G95G	NM_003720	NP_003711	O95456	PSMG1_HUMAN	Down syndrome critical region protein 2 isoform	182					proteasome assembly	endoplasmic reticulum	protein binding				0		Prostate(19;8.44e-08)				AAGGAAGGCTGCCGGTGGATT	0.423			NA											13	116					0	0	0.00245	0	0
ABCG1	9619	broad.mit.edu	37	21	43705992	43705992	+	Silent	SNP	T	T	C			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr21:43705992T>C	uc002zaq.2	+	8	967	c.861T>C	c.(859-861)CTT>CTC	p.L287L	ABCG1_uc002zan.2_Silent_p.L289L|ABCG1_uc002zam.2_Silent_p.L265L|ABCG1_uc002zao.2_Silent_p.L284L|ABCG1_uc002zap.2_Silent_p.L287L|ABCG1_uc002zar.2_Silent_p.L298L|ABCG1_uc011aev.1_Silent_p.L298L|ABCG1_uc010gpb.1_5'UTR	NM_004915	NP_004906	P45844	ABCG1_HUMAN	ATP-binding cassette sub-family G member 1	287	Cytoplasmic (Potential).|ABC transporter.				amyloid precursor protein catabolic process|cholesterol efflux|cholesterol homeostasis|cholesterol metabolic process|detection of hormone stimulus|high-density lipoprotein particle remodeling|intracellular cholesterol transport|lipoprotein metabolic process|low-density lipoprotein particle remodeling|negative regulation of cholesterol storage|negative regulation of macrophage derived foam cell differentiation|phospholipid efflux|phospholipid homeostasis|positive regulation of cholesterol biosynthetic process|regulation of cholesterol esterification|regulation of transcription, DNA-dependent|response to lipid|reverse cholesterol transport	endoplasmic reticulum membrane|external side of plasma membrane|Golgi membrane|recycling endosome	ADP binding|ATP binding|cholesterol transporter activity|glycoprotein transporter activity|phospholipid transporter activity|protein heterodimerization activity|protein homodimerization activity|sterol-transporting ATPase activity|toxin transporter activity			ovary(2)|central_nervous_system(1)	3					Adenosine triphosphate(DB00171)	TTTTCCAGCTTTACGTCCTGA	0.423			NA											9	237					0	0	0.006214	0	0
PDE9A	5152	broad.mit.edu	37	21	44151935	44151935	+	Silent	SNP	G	G	A			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr21:44151935G>A	uc002zbm.2	+	5	381	c.318G>A	c.(316-318)CTG>CTA	p.L106L	PDE9A_uc002zbn.2_Intron|PDE9A_uc002zbo.2_Intron|PDE9A_uc002zbp.2_5'UTR|PDE9A_uc002zbq.2_Intron|PDE9A_uc002zbs.2_Intron|PDE9A_uc002zbr.2_Intron|PDE9A_uc002zbt.2_Intron|PDE9A_uc002zbu.2_Intron|PDE9A_uc002zbv.2_Intron|PDE9A_uc002zbw.2_Intron|PDE9A_uc002zbx.2_Intron|PDE9A_uc002zby.2_Intron|PDE9A_uc002zbz.2_Intron|PDE9A_uc002zca.2_Silent_p.L65L|PDE9A_uc002zcb.2_Silent_p.L80L|PDE9A_uc002zcc.2_Intron|PDE9A_uc002zcd.2_Intron|PDE9A_uc002zce.2_Silent_p.L39L|PDE9A_uc002zcf.2_5'UTR|PDE9A_uc002zcg.2_Intron|PDE9A_uc002zch.2_5'UTR	NM_002606	NP_002597	O76083	PDE9A_HUMAN	phosphodiesterase 9A isoform a	106					platelet activation|signal transduction	cytosol|endoplasmic reticulum|Golgi apparatus|perinuclear region of cytoplasm|ruffle membrane	3',5'-cyclic-GMP phosphodiesterase activity|metal ion binding|protein binding			ovary(1)|skin(1)	2						AGAGACCACTGAGGGACAGAC	0.582			NA											11	89					0	0	0.001368	0	0
FTCD	10841	broad.mit.edu	37	21	47571634	47571634	+	Missense_Mutation	SNP	C	C	A			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr21:47571634C>A	uc002zif.2	-	5	518	c.474G>T	c.(472-474)TGG>TGT	p.W158C	FTCD_uc002zig.2_Missense_Mutation_p.W158C|FTCD_uc002zih.2_Missense_Mutation_p.W158C|FTCD_uc010gqf.2_Missense_Mutation_p.W158C|FTCD_uc010gqg.1_Missense_Mutation_p.W27C	NM_006657	NP_006648	O95954	FTCD_HUMAN	formiminotransferase cyclodeaminase	158	Formiminotransferase N-subdomain (By similarity).				folic acid-containing compound metabolic process|histidine catabolic process	centriole|cytosol|Golgi apparatus	folic acid binding|formimidoyltetrahydrofolate cyclodeaminase activity|glutamate formimidoyltransferase activity			pancreas(1)|skin(1)	2	Breast(49;0.214)			Colorectal(79;0.235)	L-Glutamic Acid(DB00142)|Pyridoxal Phosphate(DB00114)|Tetrahydrofolic acid(DB00116)	AGTCGGGCGCCCAGTCGGCCT	0.672			NA											10	35					2.17888e-05	2.78385e-05	0.006214	1	0
ZNF280A	129025	broad.mit.edu	37	22	22869861	22869861	+	Missense_Mutation	SNP	G	G	C			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr22:22869861G>C	uc002zwe.2	-	2	347	c.94C>G	c.(94-96)CTG>GTG	p.L32V	LOC96610_uc011aim.1_Intron	NM_080740	NP_542778	P59817	Z280A_HUMAN	zinc finger protein 280A	32					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1	all_hematologic(9;0.0135)|Acute lymphoblastic leukemia(84;0.17)	all_hematologic(6;1.74e-30)|Acute lymphoblastic leukemia(6;7.75e-22)		READ - Rectum adenocarcinoma(21;0.145)		ACATAGATCAGATCTGGATCT	0.378			NA											3	98					0	0	0.004672	0	0
MYO18B	84700	broad.mit.edu	37	22	26423257	26423257	+	Silent	SNP	G	G	T			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr22:26423257G>T	uc003abz.1	+	43	7567	c.7317G>T	c.(7315-7317)GTG>GTT	p.V2439V	MYO18B_uc003aca.1_Silent_p.V2320V|MYO18B_uc010guy.1_Silent_p.V2321V|MYO18B_uc010guz.1_Silent_p.V2319V|MYO18B_uc011aka.1_Silent_p.V1593V|MYO18B_uc011akb.1_Silent_p.V1952V|MYO18B_uc010gva.1_Silent_p.V422V|MYO18B_uc010gvb.1_RNA	NM_032608	NP_115997	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	2439						nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity			ovary(5)|central_nervous_system(3)|large_intestine(2)|breast(2)	12						AGACCAAAGTGGACTTCGATG	0.562			NA											13	95					3.41278e-10	5.08325e-10	0.00499	1	0
FANCD2	2177	broad.mit.edu	37	3	10106096	10106096	+	Silent	SNP	C	C	T	rs138189144	byFrequency	TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr3:10106096C>T	uc003buw.2	+	22	2082	c.2004C>T	c.(2002-2004)TCC>TCT	p.S668S	FANCD2_uc003bux.1_Silent_p.S668S|FANCD2_uc003buy.1_Silent_p.S668S|FANCD2_uc010hcw.1_RNA	NM_033084	NP_149075	Q9BXW9	FACD2_HUMAN	Fanconi anemia complementation group D2 isoform	668					DNA repair|response to gamma radiation	nucleoplasm	protein binding|protein binding			central_nervous_system(2)|ovary(1)|skin(1)	4				OV - Ovarian serous cystadenocarcinoma(96;0.148)		TAGTGGACTCCTGTGTTGTTC	0.443			NA	D|Mis|N|F			AML|leukemia		Involved_in_tolerance_or_repair_of_DNA_crosslinks	FanconAnemia				5	312					0	0	0.00245	0	0
BTD	686	broad.mit.edu	37	3	15677058	15677058	+	Missense_Mutation	SNP	T	T	A			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr3:15677058T>A	uc003cah.2	+	2	275	c.172T>A	c.(172-174)TAT>AAT	p.Y58N	BTD_uc011avv.1_Missense_Mutation_p.Y60N|BTD_uc011avw.1_Missense_Mutation_p.Y60N|BTD_uc011avx.1_Missense_Mutation_p.Y38N	NM_000060	NP_000051	P43251	BTD_HUMAN	biotinidase precursor	58	CN hydrolase.				central nervous system development|epidermis development|nitrogen compound metabolic process	extracellular space	biotin carboxylase activity|biotinidase activity				0						GGCTGAATATTATGTGGCTGC	0.562			NA											4	110					0	0	0.000248	0	0
RARB	5915	broad.mit.edu	37	3	25611292	25611292	+	Silent	SNP	G	G	A			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr3:25611292G>A	uc011awl.1	+	4	579	c.513G>A	c.(511-513)AAG>AAA	p.K171K	RARB_uc003cdi.1_Silent_p.K52K|RARB_uc003cdh.2_Silent_p.K164K	NM_016152	NP_057236	P10826	RARB_HUMAN	retinoic acid receptor, beta isoform 2	171	Hinge.				embryonic digestive tract development|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	cytoplasm|nucleoplasm	protein binding|retinoic acid receptor activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			ovary(1)|large_intestine(1)|pancreas(1)	3					Acitretin(DB00459)|Adapalene(DB00210)|Alitretinoin(DB00523)|Etretinate(DB00926)|Tamibarotene(DB04942)|Tazarotene(DB00799)	AGACTTCGAAGCAAGAATGCA	0.507			NA											4	55					0	0	0.000248	0	0
NEK10	152110	broad.mit.edu	37	3	27204002	27204002	+	Missense_Mutation	SNP	C	C	A			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr3:27204002C>A	uc010hfk.2	-	10	1125	c.896G>T	c.(895-897)TGG>TTG	p.W299L	NEK10_uc003cds.1_Missense_Mutation_p.W384L|NEK10_uc010hfj.2_Intron			Q6ZWH5	NEK10_HUMAN	RecName: Full=Serine/threonine-protein kinase Nek10;          EC=2.7.11.1; AltName: Full=NimA-related protein kinase 10;	987							ATP binding|metal ion binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(5)|stomach(2)|central_nervous_system(2)|lung(2)|skin(1)|pancreas(1)	13						ATGGGACTGCCACCCTGTCAC	0.463			NA											5	74					1.23904e-05	1.59024e-05	0.000602	1	0
MYD88	4615	broad.mit.edu	37	3	38182678	38182678	+	Silent	SNP	C	C	T			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr3:38182678C>T	uc003chx.2	+	5	1039	c.855C>T	c.(853-855)TTC>TTT	p.F285F	MYD88_uc011ayi.1_Silent_p.F277F|MYD88_uc011ayj.1_3'UTR|MYD88_uc011ayk.1_3'UTR|MYD88_uc011ayl.1_Silent_p.F232F	NM_002468	NP_002459	Q99836	MYD88_HUMAN	myeloid differentiation primary response gene	264	TIR.				3'-UTR-mediated mRNA stabilization|anti-apoptosis|cellular response to mechanical stimulus|inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-17 production|positive regulation of interleukin-23 production|positive regulation of interleukin-6 production|regulation of inflammatory response|response to interleukin-1|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|endosome membrane|intrinsic to membrane|plasma membrane	death receptor binding|TIR domain binding|transmembrane receptor activity			haematopoietic_and_lymphoid_tissue(93)|breast(1)	94				KIRC - Kidney renal clear cell carcinoma(284;0.0517)|Kidney(284;0.065)		AGAAAGAGTTCCCCAGCATCC	0.562			NA	Mis 		ABC-DLBCL								23	103					0	0	0.002299	0	0
CCR8	1237	broad.mit.edu	37	3	39374724	39374724	+	Missense_Mutation	SNP	C	C	A			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr3:39374724C>A	uc010hhr.2	+	2	1040	c.902C>A	c.(901-903)GCT>GAT	p.A301D	CCR8_uc003cjm.2_Missense_Mutation_p.A218D	NM_005201	NP_005192	P51685	CCR8_HUMAN	chemokine (C-C motif) receptor 8	301	Helical; Name=7; (Potential).				cell adhesion|chemotaxis|elevation of cytosolic calcium ion concentration|immune response	integral to plasma membrane	coreceptor activity			ovary(1)|lung(1)	2				KIRC - Kidney renal clear cell carcinoma(284;0.0504)|Kidney(284;0.0635)		GTTATCTATGCTTTTGTTGGG	0.423			NA											10	88					9.70103e-10	1.43738e-09	0.008291	1	0
FYCO1	79443	broad.mit.edu	37	3	46009082	46009082	+	Missense_Mutation	SNP	G	G	T			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr3:46009082G>T	uc003cpb.3	-	8	1950	c.1744C>A	c.(1744-1746)CAA>AAA	p.Q582K	FYCO1_uc011bal.1_Missense_Mutation_p.Q582K	NM_024513	NP_078789	Q9BQS8	FYCO1_HUMAN	FYVE and coiled-coil domain containing 1	582					transport	integral to membrane	metal ion binding|protein binding			central_nervous_system(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.00147)|KIRC - Kidney renal clear cell carcinoma(197;0.0272)|Kidney(197;0.0323)		CAGGCCTCTTGCAGACTGGAG	0.637			NA											10	96					7.48243e-07	1.01075e-06	0.006214	1	0
SETD2	29072	broad.mit.edu	37	3	47162939	47162939	+	Nonsense_Mutation	SNP	T	T	A			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr3:47162939T>A	uc003cqs.2	-	3	3240	c.3187A>T	c.(3187-3189)AGA>TGA	p.R1063*	SETD2_uc003cqv.2_Nonsense_Mutation_p.R1052*	NM_014159	NP_054878	Q9BYW2	SETD2_HUMAN	SET domain containing 2	1063					regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	DNA binding|histone-lysine N-methyltransferase activity|oxidoreductase activity|transition metal ion binding			kidney(24)|ovary(5)|skin(1)|central_nervous_system(1)|breast(1)	32		Acute lymphoblastic leukemia(5;0.0169)		BRCA - Breast invasive adenocarcinoma(193;0.000302)|KIRC - Kidney renal clear cell carcinoma(197;0.00732)|Kidney(197;0.00844)		AGACGGTTTCTTGGAATACTG	0.393			NA	N|F|S|Mis		clear cell renal carcinoma								12	84					0	0	0.001368	0	0
TRAIP	10293	broad.mit.edu	37	3	49866942	49866942	+	Splice_Site	SNP	C	C	A			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr3:49866942C>A	uc003cxs.1	-	14	1343	c.1237_splice	c.e14-1	p.V413_splice	TRAIP_uc010hla.1_Splice_Site_p.V314_splice	NM_005879	NP_005870	Q9BWF2	TRAIP_HUMAN	TRAF interacting protein						cell proliferation|induction of apoptosis	perinuclear region of cytoplasm	protein binding|zinc ion binding			lung(4)|upper_aerodigestive_tract(1)|ovary(1)	6				BRCA - Breast invasive adenocarcinoma(193;4.71e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		CTGTCCTTACCTAGGGTGGAA	0.577			NA											4	54					0.000602214	0.000713082	0.000602	1	0
TLR9	54106	broad.mit.edu	37	3	52257634	52257634	+	Missense_Mutation	SNP	A	A	G			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr3:52257634A>G	uc003dda.1	-	2	1332	c.698T>C	c.(697-699)GTC>GCC	p.V233A	TLR9_uc003ddb.2_Missense_Mutation_p.V330A	NM_017442	NP_059138	Q9NR96	TLR9_HUMAN	toll-like receptor 9 isoform A precursor	233	LRR 7.|Extracellular (Potential).				defense response to bacterium|fibroblast growth factor receptor signaling pathway|I-kappaB phosphorylation|inflammatory response|innate immune response|insulin receptor signaling pathway|maintenance of gastrointestinal epithelium|negative regulation of interleukin-6 production|negative regulation of interleukin-8 production|negative regulation of NF-kappaB transcription factor activity|negative regulation of toll-like receptor signaling pathway|positive regulation of chemokine production|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interferon-alpha biosynthetic process|positive regulation of interferon-beta biosynthetic process|positive regulation of interferon-beta production|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-10 production|positive regulation of interleukin-12 production|positive regulation of interleukin-18 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of JUN kinase activity|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of toll-like receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|response to molecule of bacterial origin	apical plasma membrane|basolateral plasma membrane|early phagosome|endoplasmic reticulum membrane|endosome membrane|extracellular region|integral to membrane|lysosome	interleukin-1 receptor binding|siRNA binding|transmembrane receptor activity			large_intestine(2)|skin(2)	4				BRCA - Breast invasive adenocarcinoma(193;2.41e-05)|Kidney(197;0.000537)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)	Chloroquine(DB00608)	CGCCAGTTTGACGATGCGGTT	0.607			NA											3	23					0	0	0.004672	0	0
ITIH3	3699	broad.mit.edu	37	3	52836352	52836352	+	Silent	SNP	C	C	T			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr3:52836352C>T	uc003dfv.2	+	12	1422	c.1386C>T	c.(1384-1386)GGC>GGT	p.G462G	ITIH3_uc011bek.1_Silent_p.G462G	NM_002217	NP_002208	Q06033	ITIH3_HUMAN	inter-alpha (globulin) inhibitor H3	462	VWFA.				hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			ovary(2)|liver(1)	3				BRCA - Breast invasive adenocarcinoma(193;7e-05)|Kidney(197;0.000656)|KIRC - Kidney renal clear cell carcinoma(197;0.000794)|OV - Ovarian serous cystadenocarcinoma(275;0.0496)		AACTTCAGGGCTTCTATGAGG	0.607			NA											3	32					0	0	0.004672	0	0
CNTN3	5067	broad.mit.edu	37	3	74350797	74350797	+	Splice_Site	SNP	C	C	G			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr3:74350797C>G	uc003dpm.1	-	14	2025	c.1945_splice	c.e14+1	p.V649_splice		NM_020872	NP_065923	Q9P232	CNTN3_HUMAN	contactin 3 precursor						cell adhesion	anchored to membrane|plasma membrane	protein binding			breast(3)|ovary(1)|skin(1)	5		Lung NSC(201;0.138)|Lung SC(41;0.21)		Epithelial(33;0.00212)|BRCA - Breast invasive adenocarcinoma(55;0.00258)|LUSC - Lung squamous cell carcinoma(21;0.00461)|Lung(16;0.01)		TCCTGCTTTACCTGTTGTGAC	0.443			NA											3	57					0	0	0.004672	0	0
IGSF11	152404	broad.mit.edu	37	3	118621429	118621429	+	Nonsense_Mutation	SNP	C	C	A			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr3:118621429C>A	uc003ebw.2	-	7	1481	c.1234G>T	c.(1234-1236)GAA>TAA	p.E412*	IGSF11_uc011biv.1_Nonsense_Mutation_p.E384*|IGSF11_uc003ebx.2_Nonsense_Mutation_p.E388*|IGSF11_uc003eby.2_Nonsense_Mutation_p.E411*|IGSF11_uc003ebz.2_Nonsense_Mutation_p.E387*|IGSF11_uc010hqs.2_Nonsense_Mutation_p.E411*	NM_001015887	NP_001015887	Q5DX21	IGS11_HUMAN	immunoglobulin superfamily, member 11 isoform b	412	Cytoplasmic (Potential).				cell adhesion|regulation of growth	integral to membrane|plasma membrane	receptor activity				0						CCAATTCGTTCCAGTGTTGCG	0.522			NA											16	128					2.23348e-06	2.98149e-06	0.004007	1	0
HEG1	57493	broad.mit.edu	37	3	124739887	124739887	+	Missense_Mutation	SNP	A	A	T			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr3:124739887A>T	uc003ehs.3	-	4	1069	c.1001T>A	c.(1000-1002)GTG>GAG	p.V334E	HEG1_uc011bke.1_Missense_Mutation_p.V334E	NM_020733	NP_065784	Q9ULI3	HEG1_HUMAN	HEG homolog 1 precursor	334	Extracellular (Potential).					extracellular region|integral to membrane	calcium ion binding			ovary(2)	2						ATCAGTGAACACGGTGGCAAC	0.512			NA											4	18					0	0	0.000248	0	0
DNAJC13	23317	broad.mit.edu	37	3	132218620	132218620	+	Missense_Mutation	SNP	C	C	T			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr3:132218620C>T	uc003eor.2	+	38	4449	c.4384C>T	c.(4384-4386)CGT>TGT	p.R1462C		NM_015268	NP_056083	O75165	DJC13_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 13	1462							heat shock protein binding			ovary(1)|breast(1)	2						TGTCTTGACTCGTGCTAGTAA	0.383			NA											12	276					0	0	0.001855	0	0
EPHB1	2047	broad.mit.edu	37	3	134920438	134920438	+	Silent	SNP	G	G	T			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr3:134920438G>T	uc003eqt.2	+	12	2473	c.2253G>T	c.(2251-2253)CTG>CTT	p.L751L	EPHB1_uc003equ.2_Silent_p.L312L	NM_004441	NP_004432	P54762	EPHB1_HUMAN	ephrin receptor EphB1 precursor	751	Cytoplasmic (Potential).|Protein kinase.					integral to plasma membrane	ATP binding|ephrin receptor activity|protein binding			lung(11)|ovary(6)|stomach(4)|breast(3)|central_nervous_system(2)|skin(2)|large_intestine(1)|pancreas(1)	30						GGAACATTCTGGTCAACAGTA	0.552			NA											29	139					2.12542e-12	3.36029e-12	0.00632	1	0
SR140	23350	broad.mit.edu	37	3	142741358	142741358	+	Missense_Mutation	SNP	G	G	T			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr3:142741358G>T	uc003evh.1	+	11	971	c.872G>T	c.(871-873)TGC>TTC	p.C291F	SR140_uc003evi.1_5'UTR|SR140_uc011bnj.1_Missense_Mutation_p.C291F|SR140_uc003evj.1_RNA|SR140_uc003evk.1_Missense_Mutation_p.C290F	NM_001080415	NP_001073884	O15042	SR140_HUMAN	U2-associated SR140 protein	291	RRM.				RNA processing	nucleus	nucleotide binding|RNA binding				0						GAAATGCTGTGCCAAGAATTT	0.348	Colon(87;897 1320 15089 19747 35974)		NA											5	151					8.12818e-05	9.95791e-05	0.001984	1	0
ZIC1	7545	broad.mit.edu	37	3	147131311	147131311	+	Silent	SNP	T	T	A			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr3:147131311T>A	uc003ewe.2	+	3	2036	c.1317T>A	c.(1315-1317)TCT>TCA	p.S439S		NM_003412	NP_003403	Q15915	ZIC1_HUMAN	zinc finger protein of the cerebellum 1	439	Ser-rich.				behavior|brain development|cell differentiation|inner ear morphogenesis|pattern specification process|positive regulation of protein import into nucleus|positive regulation of transcription, DNA-dependent|regulation of smoothened signaling pathway	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2						GTGCGCTCTCTTCCAATTTTA	0.478			NA											11	58					0	0	0.000978	0	0
CPA3	1359	broad.mit.edu	37	3	148596504	148596504	+	Missense_Mutation	SNP	C	C	A			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr3:148596504C>A	uc003ewm.2	+	5	495	c.443C>A	c.(442-444)ACT>AAT	p.T148N		NM_001870	NP_001861	P15088	CBPA3_HUMAN	carboxypeptidase A3 precursor	148					proteolysis	stored secretory granule|transport vesicle	metallocarboxypeptidase activity|zinc ion binding			breast(1)|skin(1)	2			LUSC - Lung squamous cell carcinoma(72;0.0934)|Lung(72;0.115)			ATTGGATCTACTGTTGAAGAT	0.294			NA											25	116					3.28513e-13	5.26737e-13	0.003954	1	0
VEPH1	79674	broad.mit.edu	37	3	156979109	156979109	+	Silent	SNP	C	C	T			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr3:156979109C>T	uc003fbj.1	-	14	2633	c.2316G>A	c.(2314-2316)GTG>GTA	p.V772V	VEPH1_uc003fbk.1_Silent_p.V772V|VEPH1_uc010hvu.1_Silent_p.V727V	NM_024621	NP_078897	Q14D04	MELT_HUMAN	ventricular zone expressed PH domain homolog 1	772	PH.					plasma membrane				breast(3)|ovary(1)|lung(1)	5			Lung(72;0.0272)|LUSC - Lung squamous cell carcinoma(72;0.0461)			CCACAGCCTTCACACTCTGTA	0.488			NA											4	67					0	0	0.000248	0	0
SI	6476	broad.mit.edu	37	3	164735354	164735354	+	Silent	SNP	C	C	A			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr3:164735354C>A	uc003fei.2	-	31	3803	c.3741G>T	c.(3739-3741)GTG>GTT	p.V1247V		NM_001041	NP_001032	P14410	SUIS_HUMAN	sucrase-isomaltase	1247	Sucrase.|Lumenal.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			ovary(7)|upper_aerodigestive_tract(4)|skin(2)|pancreas(1)	14		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	TGTTAGCAGCCACCATAGCGT	0.338			NA								HNSCC(35;0.089)			6	42					0.00198382	0.0022822	0.001984	1	0
PLD1	5337	broad.mit.edu	37	3	171395446	171395446	+	Missense_Mutation	SNP	C	C	T			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr3:171395446C>T	uc003fhs.2	-	17	2022	c.1906G>A	c.(1906-1908)GAG>AAG	p.E636K	PLD1_uc003fht.2_Missense_Mutation_p.E598K|PLD1_uc003fhv.1_5'UTR	NM_002662	NP_002653	Q13393	PLD1_HUMAN	phospholipase D1 isoform a	636	Catalytic.				cell communication|chemotaxis|Ras protein signal transduction	endoplasmic reticulum membrane|Golgi membrane|late endosome membrane|perinuclear region of cytoplasm	NAPE-specific phospholipase D activity|phosphatidylinositol binding|phospholipase D activity			ovary(2)|lung(1)	3	all_cancers(22;4.53e-19)|Ovarian(172;0.00197)|Breast(254;0.186)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)		Choline(DB00122)	CCATGCAGCTCTCCCACACCT	0.498	NSCLC(149;2174 3517 34058)		NA											4	122					0	0	0.000248	0	0
ZNF639	51193	broad.mit.edu	37	3	179051750	179051750	+	Missense_Mutation	SNP	A	A	C			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr3:179051750A>C	uc003fjq.1	+	6	1341	c.998A>C	c.(997-999)CAT>CCT	p.H333P	ZNF639_uc003fjr.1_Missense_Mutation_p.H333P	NM_016331	NP_057415	Q9UID6	ZN639_HUMAN	zinc finger protein 639	333					initiation of viral infection|negative regulation by host of viral transcription|negative regulation of transcription, DNA-dependent|positive regulation by host of viral transcription|positive regulation of cell growth|positive regulation of transcription, DNA-dependent	nucleus	protein self-association|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|zinc ion binding				0	all_cancers(143;7.9e-17)|Ovarian(172;0.0172)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;5.78e-26)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0923)			GAAGACTTGCATAGCCATGTG	0.383			NA											10	90					0	0	0.006214	0	0
ECE2	9718	broad.mit.edu	37	3	183967486	183967486	+	Missense_Mutation	SNP	G	G	A			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr3:183967486G>A	uc003fni.3	+	1	42	c.4G>A	c.(4-6)GCC>ACC	p.A2T	ALG3_uc003fne.2_5'Flank|ALG3_uc011brc.1_5'Flank|ALG3_uc011brd.1_5'Flank|ALG3_uc011bre.1_5'Flank|ALG3_uc003fnf.1_5'Flank|ALG3_uc011brf.1_5'Flank|ECE2_uc003fnh.3_Missense_Mutation_p.A2T	NM_014693	NP_055508	O60344	ECE2_HUMAN	endothelin converting enzyme 2 isoform A	2	Cytoplasmic (Potential).|Methyltransferase-like region.				brain development|cardioblast differentiation|cell-cell signaling|peptide hormone processing	cytoplasmic vesicle membrane|Golgi membrane|integral to membrane	metal ion binding|metalloendopeptidase activity|methyltransferase activity			ovary(2)|skin(2)	4	all_cancers(143;1.39e-10)|Ovarian(172;0.0339)		Epithelial(37;8.28e-34)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			TGAGAGCATGGCCTCTCCAGG	0.682			NA									OREG0015944	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	3	21					0	0	0.000248	0	0
EIF4G1	1981	broad.mit.edu	37	3	184043360	184043360	+	Missense_Mutation	SNP	C	C	G			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr3:184043360C>G	uc003fnp.2	+	20	3252	c.3054C>G	c.(3052-3054)ATC>ATG	p.I1018M	EIF4G1_uc003fnt.2_Missense_Mutation_p.I729M|EIF4G1_uc003fnq.2_Missense_Mutation_p.I931M|EIF4G1_uc003fnr.2_Missense_Mutation_p.I854M|EIF4G1_uc010hxx.2_Missense_Mutation_p.I1025M|EIF4G1_uc003fns.2_Missense_Mutation_p.I978M|EIF4G1_uc010hxy.2_Missense_Mutation_p.I1025M|EIF4G1_uc003fnv.3_Missense_Mutation_p.I1019M|EIF4G1_uc003fnu.3_Missense_Mutation_p.I1018M|EIF4G1_uc003fnw.2_Missense_Mutation_p.I1025M|EIF4G1_uc003fnx.2_Missense_Mutation_p.I823M|EIF4G1_uc003fny.3_Missense_Mutation_p.I822M|SNORD66_uc003fnz.2_5'Flank	NM_198241	NP_937884	Q04637	IF4G1_HUMAN	eukaryotic translation initiation factor 4	1018	eIF3/EIF4A-binding.				insulin receptor signaling pathway|interspecies interaction between organisms|nuclear-transcribed mRNA poly(A) tail shortening|regulation of translational initiation	cytosol|eukaryotic translation initiation factor 4F complex	protein binding|translation initiation factor activity			lung(2)|ovary(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	7	all_cancers(143;1.06e-10)|Ovarian(172;0.0339)		Epithelial(37;1.53e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			GAGAGCACATCAAAGTGCAGC	0.582			NA											16	95					0	0	0.003163	0	0
FAM131A	131408	broad.mit.edu	37	3	184060021	184060021	+	Missense_Mutation	SNP	G	G	C			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr3:184060021G>C	uc003fog.2	+	1	1764	c.400G>C	c.(400-402)GCT>CCT	p.A134P	FAM131A_uc003fob.1_Missense_Mutation_p.A42P|FAM131A_uc003foc.2_Missense_Mutation_p.A80P|FAM131A_uc003foe.2_Missense_Mutation_p.A80P	NM_144635	NP_653236	Q6UXB0	F131A_HUMAN	hypothetical protein LOC131408 precursor	134						extracellular region				breast(1)	1	all_cancers(143;1.06e-10)|Ovarian(172;0.0339)		Epithelial(37;1.53e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			CGAACAAGAGGCTCGCTTTGC	0.463			NA											3	106					0	0	0.004672	0	0
SENP2	59343	broad.mit.edu	37	3	185347571	185347571	+	Missense_Mutation	SNP	A	A	G			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr3:185347571A>G	uc003fpn.2	+	17	1880	c.1709A>G	c.(1708-1710)CAC>CGC	p.H570R	SENP2_uc011brv.1_Missense_Mutation_p.H560R|SENP2_uc011brw.1_Missense_Mutation_p.H383R	NM_021627	NP_067640	Q9HC62	SENP2_HUMAN	SUMO1/sentrin/SMT3 specific protease 2	570					mRNA transport|protein desumoylation|protein transport|proteolysis|regulation of Wnt receptor signaling pathway|transmembrane transport|Wnt receptor signaling pathway	cytoplasm|nuclear membrane|nuclear pore	protein binding|SUMO-specific protease activity				0	all_cancers(143;1.28e-10)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(80;1.31e-21)			TCTTTGCAGCACCAGATGCCT	0.473			NA											4	92					0	0	0.000602	0	0
PDE6B	5158	broad.mit.edu	37	4	619540	619540	+	Missense_Mutation	SNP	C	C	A			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr4:619540C>A	uc003gap.2	+	1	178	c.125C>A	c.(124-126)CCG>CAG	p.P42Q	PDE6B_uc003gao.3_Missense_Mutation_p.P42Q	NM_000283	NP_000274	P35913	PDE6B_HUMAN	phosphodiesterase 6B isoform 1	42					cytosolic calcium ion homeostasis|GMP metabolic process|phototransduction, visible light|platelet activation|visual perception	cytosol|membrane	3',5'-cyclic-GMP phosphodiesterase activity|metal ion binding				0						GGGTGCCCGCCGGACTGCGAC	0.517	GBM(71;463 1194 9848 25922 46834)		NA											6	53					0.00116845	0.00135799	0.001168	1	0
RGS12	6002	broad.mit.edu	37	4	3429845	3429845	+	Silent	SNP	A	A	T			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr4:3429845A>T	uc003ggw.2	+	15	4264	c.3360A>T	c.(3358-3360)CCA>CCT	p.P1120P	RGS12_uc003ggv.2_Silent_p.P1120P|RGS12_uc003ggy.1_Silent_p.P518P|RGS12_uc003ggz.2_Silent_p.P472P|RGS12_uc010icu.1_Silent_p.P319P|RGS12_uc011bvs.1_Silent_p.P462P|RGS12_uc003gha.2_Silent_p.P462P|RGS12_uc010icv.2_Silent_p.P319P|RGS12_uc003ghb.2_Silent_p.P319P	NM_198229	NP_937872	O14924	RGS12_HUMAN	regulator of G-protein signalling 12 isoform 1	1120						condensed nuclear chromosome|cytoplasm|plasma membrane	GTPase activator activity|receptor signaling protein activity			skin(1)	1				UCEC - Uterine corpus endometrioid carcinoma (64;0.168)		AAGGTGTGCCAGTGAAACAGA	0.502			NA											10	163					0	0	0.008291	0	0
MSX1	4487	broad.mit.edu	37	4	4864535	4864535	+	Missense_Mutation	SNP	C	C	A	rs104893850		TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr4:4864535C>A	uc003gif.2	+	2	812	c.577C>A	c.(577-579)CAG>AAG	p.Q193K		NM_002448	NP_002439	P28360	MSX1_HUMAN	msh homeobox 1	187	Homeobox.				apoptotic nuclear change|face morphogenesis|negative regulation of cell growth|odontogenesis of dentine-containing tooth|positive regulation of apoptosis|protein localization to nucleus|protein stabilization	nucleus	p53 binding|sequence-specific DNA binding transcription factor activity				0				UCEC - Uterine corpus endometrioid carcinoma (64;0.163)		CAAGTTCCGCCAGAAGCAGTA	0.652			NA											7	70					8.12818e-05	9.95791e-05	0.001984	1	0
STK32B	55351	broad.mit.edu	37	4	5333033	5333033	+	Missense_Mutation	SNP	T	T	A			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr4:5333033T>A	uc003gih.1	+	4	411	c.347T>A	c.(346-348)GTG>GAG	p.V116E	STK32B_uc010ida.1_Missense_Mutation_p.V69E	NM_018401	NP_060871	Q9NY57	ST32B_HUMAN	serine/threonine kinase 32B	116	Protein kinase.						ATP binding|metal ion binding|protein serine/threonine kinase activity			breast(2)|large_intestine(1)|central_nervous_system(1)|skin(1)	5						CAGCAGAATGTGCATTTCACA	0.547			NA											5	48					0	0	0.000602	0	0
ARAP2	116984	broad.mit.edu	37	4	36179480	36179481	+	Missense_Mutation	DNP	CC	CC	AT			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr4:36179480_36179481CC>AT	uc003gsq.1	-	9	2163_2164	c.1825_1826GG>AT	c.(1825-1827)GGA>ATA	p.G609I	ARAP2_uc003gsr.1_Missense_Mutation_p.G609I	NM_015230	NP_056045	Q8WZ64	ARAP2_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH	609	PH 2.				regulation of ARF GTPase activity|small GTPase mediated signal transduction	cytosol	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|zinc ion binding			ovary(1)|pancreas(1)|skin(1)	3						CACACTGTTTCCACTTAACACA	0.366			NA											9	81					0	0	0.004672	0	0
CORIN	10699	broad.mit.edu	37	4	47625744	47625744	+	Missense_Mutation	SNP	G	G	A			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr4:47625744G>A	uc003gxm.2	-	19	2477	c.2384C>T	c.(2383-2385)GCT>GTT	p.A795V	CORIN_uc011bzf.1_Missense_Mutation_p.A656V|CORIN_uc011bzg.1_Missense_Mutation_p.A728V	NM_006587	NP_006578	Q9Y5Q5	CORIN_HUMAN	corin	795	Extracellular (Potential).|SRCR.				peptide hormone processing|regulation of systemic arterial blood pressure by atrial natriuretic peptide	integral to membrane|plasma membrane	scavenger receptor activity|serine-type endopeptidase activity|serine-type exopeptidase activity			ovary(1)|central_nervous_system(1)	2						CATTCGGGCAGCAGGGCGGCG	0.532			NA											4	64					0	0	0.000602	0	0
SRD5A3	79644	broad.mit.edu	37	4	56230429	56230429	+	Missense_Mutation	SNP	G	G	C			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr4:56230429G>C	uc003hau.2	+	3	648	c.553G>C	c.(553-555)GGC>CGC	p.G185R	uc003hav.1_RNA	NM_024592	NP_078868	Q9H8P0	PORED_HUMAN	steroid 5 alpha-reductase 3	185	Cytoplasmic (Potential).				androgen biosynthetic process|dolichol metabolic process|dolichol-linked oligosaccharide biosynthetic process|polyprenol catabolic process	endoplasmic reticulum membrane|integral to membrane	3-oxo-5-alpha-steroid 4-dehydrogenase activity|oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor				0	all_cancers(7;0.0308)|all_lung(4;0.00195)|Lung NSC(11;0.00431)|all_epithelial(27;0.0425)|Glioma(25;0.08)|all_neural(26;0.101)		Epithelial(7;0.0179)			GCCAATGGATGGCAGGAATGG	0.522			NA											5	43					0	0	0.000602	0	0
LPHN3	23284	broad.mit.edu	37	4	62775293	62775293	+	Missense_Mutation	SNP	A	A	G			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr4:62775293A>G	uc010ihh.2	+	9	1872	c.1699A>G	c.(1699-1701)ACA>GCA	p.T567A	LPHN3_uc003hcq.3_Missense_Mutation_p.T567A|LPHN3_uc003hct.2_5'UTR|LPHN3_uc003hcs.1_Missense_Mutation_p.T396A	NM_015236	NP_056051	Q9HAR2	LPHN3_HUMAN	latrophilin 3 precursor	567	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|sugar binding			lung(15)|ovary(1)|central_nervous_system(1)|pancreas(1)	18						ATCTGGTGAAACAGCTGCCAA	0.408			NA											4	26					0	0	0.000248	0	0
CSN1S1	1446	broad.mit.edu	37	4	70802196	70802196	+	Missense_Mutation	SNP	G	G	A			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr4:70802196G>A	uc003hep.1	+	6	201	c.152G>A	c.(151-153)AGG>AAG	p.R51K	CSN1S1_uc003heq.1_Missense_Mutation_p.R51K|CSN1S1_uc003her.1_Missense_Mutation_p.R51K	NM_001890	NP_001881	P47710	CASA1_HUMAN	casein alpha s1 isoform 1	51						extracellular region	protein binding|transporter activity				0						GGTATGAACAGGGTAAGAAAC	0.274			NA											4	41					0	0	0.001168	0	0
NUP54	53371	broad.mit.edu	37	4	77057381	77057381	+	Silent	SNP	C	C	A			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr4:77057381C>A	uc003hjs.2	-	4	608	c.480G>T	c.(478-480)CCG>CCT	p.P160P	NUP54_uc010ije.2_Intron|NUP54_uc011cbs.1_Intron|NUP54_uc011cbt.1_Silent_p.P112P|NUP54_uc003hjt.2_Intron	NM_017426	NP_059122	Q7Z3B4	NUP54_HUMAN	nucleoporin 54kDa	160	9 X 2 AA repeats of F-G.				carbohydrate metabolic process|glucose transport|mRNA transport|regulation of glucose transport|transmembrane transport|viral reproduction	cytoplasm|nuclear membrane|nuclear pore|nucleoplasm				ovary(1)|lung(1)	2						ATTCCACTGGCGGAATATTAT	0.348			NA											8	89					0.00448238	0.00511498	0.004482	1	0
WDFY3	23001	broad.mit.edu	37	4	85731418	85731418	+	Missense_Mutation	SNP	G	G	C			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr4:85731418G>C	uc003hpd.2	-	14	2375	c.1967C>G	c.(1966-1968)TCC>TGC	p.S656C	WDFY3_uc003hpf.2_Missense_Mutation_p.S656C	NM_014991	NP_055806	Q8IZQ1	WDFY3_HUMAN	WD repeat and FYVE domain containing 3 isoform	656						cytoplasmic part|extrinsic to membrane|nuclear envelope	1-phosphatidylinositol binding|metal ion binding|protein binding			ovary(2)|central_nervous_system(1)	3		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000808)		AACGAGCAAGGATGTAATGTA	0.438			NA											5	50					0	0	0.000602	0	0
SNCA	6622	broad.mit.edu	37	4	90743475	90743476	+	Missense_Mutation	DNP	TG	TG	CC			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	TG	TG	-	-	TG	TG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr4:90743475_90743476TG>CC	uc003hsq.2	-	4	486_487	c.227_228CA>GG	c.(226-228)GCA>GGG	p.A76G	SNCA_uc010ikt.2_Missense_Mutation_p.A62G|SNCA_uc003hso.2_Missense_Mutation_p.A76G|SNCA_uc003hsp.2_Missense_Mutation_p.A76G|SNCA_uc003hsr.2_Missense_Mutation_p.A76G	NM_001146054	NP_001139526	P37840	SYUA_HUMAN	alpha-synuclein isoform NACP140	76				Missing: Impairs polymerization into amyloid fibrils.|Missing: Impairs polymerization into amyloid fibrils.|Missing: Does not affect polymerization into amyloid fibrils.	activation of caspase activity|anti-apoptosis|negative regulation of dopamine uptake|negative regulation of exocytosis|negative regulation of histone acetylation|negative regulation of microtubule polymerization|negative regulation of monooxygenase activity|negative regulation of norepinephrine uptake|negative regulation of platelet-derived growth factor receptor signaling pathway|negative regulation of serotonin uptake|negative regulation of thrombin receptor signaling pathway|negative regulation of transporter activity|positive regulation of endocytosis|positive regulation of inositol phosphate biosynthetic process|positive regulation of peptidyl-serine phosphorylation|positive regulation of protein serine/threonine kinase activity|positive regulation of receptor recycling|positive regulation of release of sequestered calcium ion into cytosol|receptor internalization|regulation of phospholipase activity|response to interferon-gamma|response to interleukin-1|response to iron(II) ion|response to lipopolysaccharide|response to magnesium ion|synaptic vesicle endocytosis	actin cytoskeleton|axon|cell cortex|cell junction|cytosol|fibril|growth cone|nucleus|synapse	alpha-tubulin binding|calcium ion binding|caspase inhibitor activity|dynein binding|ferrous iron binding|histone binding|Hsp70 protein binding|kinesin binding|magnesium ion binding|phosphoprotein binding|tau protein binding|zinc ion binding				0		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;7.42e-05)	Melatonin(DB01065)	TCTGGGCTACTGCTGTCACACC	0.505			NA											3	53					0	0	0.004672	0	0
ADH6	130	broad.mit.edu	37	4	100131598	100131598	+	Silent	SNP	A	A	G			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr4:100131598A>G	uc003hup.3	-	4	418	c.324T>C	c.(322-324)TCT>TCC	p.S108S	uc003hum.1_Intron|ADH6_uc003huo.2_Silent_p.S108S|ADH6_uc011cef.1_5'UTR|ADH6_uc010ile.2_Silent_p.S108S	NM_000672	NP_000663	P28332	ADH6_HUMAN	class V alcohol dehydrogenase isoform 2	108					ethanol oxidation|response to ethanol|xenobiotic metabolic process	cytosol	alcohol dehydrogenase (NAD) activity|electron carrier activity|zinc ion binding			ovary(1)|kidney(1)|skin(1)	3				OV - Ovarian serous cystadenocarcinoma(123;3.58e-08)	Abacavir(DB01048)|NADH(DB00157)	AATTGCCCTCAGAATTCAGGC	0.303			NA											7	90					0	0	0.004482	0	0
MTTP	4547	broad.mit.edu	37	4	100532599	100532599	+	Missense_Mutation	SNP	C	C	T			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr4:100532599C>T	uc003hvc.3	+	15	2234	c.1978C>T	c.(1978-1980)CAC>TAC	p.H660Y	MTTP_uc011cej.1_Missense_Mutation_p.H687Y	NM_000253	NP_000244	P55157	MTP_HUMAN	microsomal triglyceride transfer protein large	660					lipid metabolic process|lipoprotein metabolic process	endoplasmic reticulum lumen	lipid binding|lipid transporter activity			ovary(3)|central_nervous_system(1)	4				OV - Ovarian serous cystadenocarcinoma(123;6.04e-09)	Hesperetin(DB01094)	GGCTGGTCTTCACGGTAGCCA	0.413			NA											9	115					0	0	0.008291	0	0
BANK1	55024	broad.mit.edu	37	4	102942739	102942739	+	Silent	SNP	A	A	G			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr4:102942739A>G	uc003hvy.3	+	8	1549	c.1275A>G	c.(1273-1275)ACA>ACG	p.T425T	BANK1_uc003hvx.3_Silent_p.T410T|BANK1_uc010ill.2_Silent_p.T292T|BANK1_uc003hvz.3_Silent_p.T395T	NM_017935	NP_060405	Q8NDB2	BANK1_HUMAN	B-cell scaffold protein with ankyrin repeats 1	425					B cell activation					ovary(2)|skin(1)	3		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;2.7e-07)		CATTTTCCACATATATTCCTT	0.219			NA											3	18					0	0	0.004672	0	0
TACR3	6870	broad.mit.edu	37	4	104511146	104511146	+	Missense_Mutation	SNP	C	C	T	rs150288991		TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr4:104511146C>T	uc003hxe.1	-	5	1234	c.1091G>A	c.(1090-1092)CGA>CAA	p.R364Q		NM_001059	NP_001050	P29371	NK3R_HUMAN	tachykinin receptor 3	364	Cytoplasmic (Potential).					integral to plasma membrane	tachykinin receptor activity			ovary(3)|lung(2)|breast(1)|skin(1)	7		Hepatocellular(203;0.217)		UCEC - Uterine corpus endometrioid carcinoma (10;0.22)|OV - Ovarian serous cystadenocarcinoma(123;3.4e-08)		GAAGCCAGCTCGAAATCTGAG	0.428			NA											7	30					0	0	0.001984	0	0
FAT4	79633	broad.mit.edu	37	4	126411064	126411064	+	Missense_Mutation	SNP	G	G	C			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr4:126411064G>C	uc003ifj.3	+	17	13087	c.13087G>C	c.(13087-13089)GAT>CAT	p.D4363H	FAT4_uc011cgp.1_Missense_Mutation_p.D2604H|FAT4_uc003ifi.1_Missense_Mutation_p.D1840H	NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	4363	Laminin G-like 2.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18						AGCAGGTTTTGATGGCTGCAT	0.408			NA											18	178					0	0	0.006122	0	0
VEGFC	7424	broad.mit.edu	37	4	177649043	177649043	+	Silent	SNP	C	C	T			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr4:177649043C>T	uc003ius.1	-	3	871	c.441G>A	c.(439-441)GCG>GCA	p.A147A		NM_005429	NP_005420	P49767	VEGFC_HUMAN	vascular endothelial growth factor C	147					angiogenesis|induction of positive chemotaxis|platelet activation|platelet degranulation|positive regulation of cell division|positive regulation of mast cell chemotaxis|substrate-dependent cell migration|vascular endothelial growth factor receptor signaling pathway	membrane|platelet alpha granule lumen	chemoattractant activity|growth factor activity			lung(5)	5		Breast(14;0.000223)|Renal(120;0.00988)|Prostate(90;0.00996)|Melanoma(52;0.0101)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;1.59e-18)|Epithelial(43;3.68e-16)|OV - Ovarian serous cystadenocarcinoma(60;8.52e-09)|GBM - Glioblastoma multiforme(59;0.000546)|STAD - Stomach adenocarcinoma(60;0.00308)|Colorectal(24;0.025)|COAD - Colon adenocarcinoma(29;0.0359)|LUSC - Lung squamous cell carcinoma(193;0.0397)		AGGTGTTTGTCGCGACTCCAA	0.498			NA											15	69					0	0	0.00499	0	0
FAT1	2195	broad.mit.edu	37	4	187522452	187522452	+	Missense_Mutation	SNP	C	C	T			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr4:187522452C>T	uc003izf.2	-	21	11799	c.11611G>A	c.(11611-11613)GCT>ACT	p.A3871T		NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor	3871	Extracellular (Potential).|Laminin G-like.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12						GTTCCTCGAGCATACATGACA	0.398	Colon(197;1040 2055 4143 4984 49344)		NA								HNSCC(5;0.00058)			10	45					0	0	0.008291	0	0
EXOC3	11336	broad.mit.edu	37	5	466932	466932	+	Silent	SNP	A	A	T			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr5:466932A>T	uc003jba.2	+	13	2285	c.2157A>T	c.(2155-2157)CCA>CCT	p.P719P	uc003jbb.1_5'Flank	NM_007277	NP_009208	O60645	EXOC3_HUMAN	Sec6 protein	730					exocytosis|protein transport						0		Ovarian(839;0.0563)	Epithelial(17;0.000529)|OV - Ovarian serous cystadenocarcinoma(19;0.00153)|all cancers(22;0.00186)|Lung(60;0.0863)			AGCAGGGCCCAGCACAGGCCA	0.657			NA											7	17					0	0	0.00308	0	0
CAPSL	133690	broad.mit.edu	37	5	35910605	35910605	+	Missense_Mutation	SNP	C	C	A			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr5:35910605C>A	uc003jjt.1	-	3	273	c.178G>T	c.(178-180)GAT>TAT	p.D60Y	CAPSL_uc003jju.1_Missense_Mutation_p.D60Y	NM_001042625	NP_001036090	Q8WWF8	CAPSL_HUMAN	calcyphosine-like	60	EF-hand 1.|1 (Potential).					cytoplasm	calcium ion binding			skin(1)	1	all_lung(31;0.000268)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Epithelial(62;0.167)|Colorectal(62;0.202)			TCTTTAAAATCAAGGGTTCGA	0.323			NA											6	61					2.7689e-08	3.92781e-08	0.001984	1	0
ACTBL2	345651	broad.mit.edu	37	5	56777979	56777979	+	Missense_Mutation	SNP	G	G	T			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr5:56777979G>T	uc003jrm.2	-	1	658	c.556C>A	c.(556-558)CTG>ATG	p.L186M		NM_001017992	NP_001017992	Q562R1	ACTBL_HUMAN	actin, beta-like 2	186						cytoplasm|cytoskeleton	ATP binding			ovary(3)	3		Lung NSC(810;0.000135)|Prostate(74;0.055)|Breast(144;0.0707)|Ovarian(174;0.182)		OV - Ovarian serous cystadenocarcinoma(10;4.24e-37)		TAATCAGTCAGGTCTCTCCCT	0.527			NA											4	81					0.00024832	0.000299041	0.000248	1	0
ARSK	153642	broad.mit.edu	37	5	94922387	94922387	+	Missense_Mutation	SNP	A	A	G			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr5:94922387A>G	uc003kld.2	+	5	979	c.821A>G	c.(820-822)AAT>AGT	p.N274S	ARSK_uc010jbg.2_Missense_Mutation_p.N115S|ARSK_uc011cum.1_RNA	NM_198150	NP_937793	Q6UWY0	ARSK_HUMAN	arylsulfatase K precursor	274						extracellular region	arylsulfatase activity|metal ion binding			pancreas(1)	1		all_cancers(142;3.38e-06)|all_epithelial(76;6.57e-09)|all_lung(232;0.00307)|Lung NSC(167;0.00452)|Ovarian(225;0.00473)		all cancers(79;6.5e-16)		GAAATTAAGAATATTAGAGCA	0.308			NA											7	52					0	0	0.00308	0	0
FBXL21	26223	broad.mit.edu	37	5	135276978	135276978	+	Missense_Mutation	SNP	C	C	T			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr5:135276978C>T	uc010jec.1	+	5	944	c.923C>T	c.(922-924)ACG>ATG	p.T308M	FBXL21_uc003lbc.2_Intron	NM_012159	NP_036291	Q9UKT6	FXL21_HUMAN	F-box and leucine-rich repeat protein 21	308					rhythmic process	ubiquitin ligase complex	ubiquitin-protein ligase activity			lung(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			GAATTCGAGACGTTCTTCAAA	0.393			NA											7	92					0	0	0.001984	0	0
KLHL3	26249	broad.mit.edu	37	5	136969802	136969802	+	Silent	SNP	G	G	A			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr5:136969802G>A	uc010jek.2	-	12	1818	c.1374C>T	c.(1372-1374)AGC>AGT	p.S458S	KLHL3_uc011cyc.1_Silent_p.S193S|KLHL3_uc003lbr.3_Silent_p.S376S|KLHL3_uc011cyd.1_Intron|KLHL3_uc010jel.1_Silent_p.S193S	NM_017415	NP_059111	Q9UH77	KLHL3_HUMAN	kelch-like 3	458	Kelch 4.					cytoplasm|cytoskeleton	actin binding|structural molecule activity				0		all_hematologic(541;3.67e-07)|Breast(839;7.61e-05)|Prostate(281;0.000825)|Ovarian(839;0.0481)|all_lung(232;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)	GBM - Glioblastoma multiforme(465;0.0223)		GCTCCACAGTGCTCAGACACT	0.567			NA											21	101					0	0	0.001523	0	0
PCDHA7	56141	broad.mit.edu	37	5	140215061	140215061	+	Missense_Mutation	SNP	C	C	G			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr5:140215061C>G	uc003lhq.2	+	1	1093	c.1093C>G	c.(1093-1095)CCA>GCA	p.P365A	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc011dac.1_Missense_Mutation_p.P365A	NM_018910	NP_061733	Q9UN72	PCDA7_HUMAN	protocadherin alpha 7 isoform 1 precursor	365	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(2)|skin(2)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGACGCCCAACCAGGTACCGT	0.502	NSCLC(160;258 2013 5070 22440 28951)		NA											7	147					0	0	0.001984	0	0
PCDHB3	56132	broad.mit.edu	37	5	140482066	140482066	+	Missense_Mutation	SNP	G	G	T			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr5:140482066G>T	uc003lio.2	+	1	1833	c.1833G>T	c.(1831-1833)GAG>GAT	p.E611D	uc003lin.2_5'Flank	NM_018937	NP_061760	Q9Y5E6	PCDB3_HUMAN	protocadherin beta 3 precursor	611	Extracellular (Potential).|Cadherin 6.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			ovary(1)|pancreas(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			AGGCCACGGAGCCCGGGCTGT	0.706			NA											8	99					1.06961e-07	1.49482e-07	0.00308	1	0
PCDHB8	56128	broad.mit.edu	37	5	140559195	140559195	+	Missense_Mutation	SNP	C	C	A			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr5:140559195C>A	uc011dai.1	+	1	1766	c.1580C>A	c.(1579-1581)GCG>GAG	p.A527E	PCDHB16_uc003liv.2_5'Flank|PCDHB16_uc010jfw.1_5'Flank	NM_019120	NP_061993	Q9UN66	PCDB8_HUMAN	protocadherin beta 8 precursor	527	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			skin(4)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GCCCTGCAGGCGTTCGAGTTC	0.687			NA											13	233					3.45872e-05	4.37949e-05	0.004007	1	0
SLC25A2	83884	broad.mit.edu	37	5	140683346	140683346	+	Silent	SNP	G	G	A			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr5:140683346G>A	uc003ljf.2	-	1	267	c.87C>T	c.(85-87)CCC>CCT	p.P29P		NM_031947	NP_114153	Q9BXI2	ORNT2_HUMAN	solute carrier family 25 member 2	29	Solcar 1.				mitochondrial ornithine transport|urea cycle	integral to membrane|mitochondrial inner membrane	L-ornithine transmembrane transporter activity			ovary(1)	1		all_lung(500;0.000249)|Lung NSC(810;0.0011)|Ovarian(839;0.00556)|Breast(839;0.0173)|all_hematologic(541;0.152)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)	GBM - Glioblastoma multiforme(465;0.00204)	L-Ornithine(DB00129)	TTGTGTCGAAGGGCTGCCCAG	0.602			NA											9	57					0	0	0.004482	0	0
GRIA1	2890	broad.mit.edu	37	5	153029928	153029928	+	Missense_Mutation	SNP	G	G	C			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr5:153029928G>C	uc003lva.3	+	4	864	c.499G>C	c.(499-501)GAG>CAG	p.E167Q	GRIA1_uc003luy.3_Missense_Mutation_p.E167Q|GRIA1_uc003luz.3_Missense_Mutation_p.E72Q|GRIA1_uc011dcv.1_RNA|GRIA1_uc011dcw.1_Missense_Mutation_p.E87Q|GRIA1_uc011dcx.1_Missense_Mutation_p.E98Q|GRIA1_uc011dcy.1_Missense_Mutation_p.E177Q|GRIA1_uc011dcz.1_Missense_Mutation_p.E177Q|GRIA1_uc010jia.1_Missense_Mutation_p.E147Q	NM_001114183	NP_001107655	P42261	GRIA1_HUMAN	glutamate receptor, ionotropic, AMPA 1 isoform	167	Extracellular (Potential).				synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|dendritic spine|endocytic vesicle membrane|endoplasmic reticulum membrane|neuronal cell body|postsynaptic density|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity|PDZ domain binding			ovary(4)|skin(2)	6		Medulloblastoma(196;0.0391)|all_neural(177;0.16)|all_hematologic(541;0.21)	Kidney(363;0.000173)|KIRC - Kidney renal clear cell carcinoma(527;0.000785)		Desflurane(DB01189)|Enflurane(DB00228)|Halothane(DB01159)|Isoflurane(DB00753)|L-Glutamic Acid(DB00142)|Methoxyflurane(DB01028)|Sevoflurane(DB01236)	TACAGCTGCTGAGAAGAACTG	0.498			NA											3	87					0	0	0.000248	0	0
CDHR2	54825	broad.mit.edu	37	5	176022636	176022636	+	Missense_Mutation	SNP	C	C	A			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr5:176022636C>A	uc003mem.1	+	32	3962	c.3896C>A	c.(3895-3897)TCC>TAC	p.S1299Y	CDHR2_uc003men.1_Missense_Mutation_p.S1299Y	NM_017675	NP_060145	Q9BYE9	CDHR2_HUMAN	protocadherin LKC precursor	1299	Cytoplasmic (Potential).				homophilic cell adhesion|negative regulation of cell growth	apical plasma membrane|cell junction|integral to membrane	calcium ion binding|protein binding			ovary(2)	2						GAGGGGCCATCCTACACCAAC	0.637			NA											24	97					7.01153e-11	1.06968e-10	0.007291	1	0
TMED9	54732	broad.mit.edu	37	5	177020659	177020659	+	Silent	SNP	G	G	A			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr5:177020659G>A	uc003mhx.2	+	3	297	c.294G>A	c.(292-294)CTG>CTA	p.L98L	TMED9_uc010jko.2_RNA	NM_017510	NP_059980	Q9BVK6	TMED9_HUMAN	transmembrane emp24 protein transport domain	98	GOLD.|Lumenal (Potential).				transport	endoplasmic reticulum membrane|ER-Golgi intermediate compartment|integral to membrane					0	all_cancers(89;0.00033)|Renal(175;0.000269)|Lung NSC(126;0.00161)|all_lung(126;0.00286)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			AGGTCATCCTGGCCCGGCAGT	0.502			NA											13	147					0	0	0.00245	0	0
FAM153C	653316	broad.mit.edu	37	5	177468724	177468724	+	Missense_Mutation	SNP	C	C	T			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr5:177468724C>T	uc011dge.1	+	7	365	c.164C>T	c.(163-165)CCA>CTA	p.P55L	FAM153C_uc003mig.1_Missense_Mutation_p.P55L	NM_001079527	NP_001072995			hypothetical protein LOC653316												0	all_cancers(89;0.00176)|Renal(175;0.000269)|Lung NSC(126;0.00858)|all_lung(126;0.0139)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			GAGCATCTGCCAGGGCAGACA	0.493			NA											28	286					0	0	0.007291	0	0
EXOC2	55770	broad.mit.edu	37	6	633069	633069	+	Missense_Mutation	SNP	G	G	C			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr6:633069G>C	uc003mtd.2	-	3	301	c.167C>G	c.(166-168)TCT>TGT	p.S56C	EXOC2_uc003mte.2_Missense_Mutation_p.S56C|EXOC2_uc011dho.1_Intron	NM_018303	NP_060773	Q96KP1	EXOC2_HUMAN	Sec5 protein	56	IPT/TIG.				exocytosis|protein transport					breast(4)|ovary(2)|pancreas(1)	7	Ovarian(93;0.0733)	Breast(5;0.0014)|all_lung(73;0.0697)|all_hematologic(90;0.0897)		OV - Ovarian serous cystadenocarcinoma(45;0.0507)|BRCA - Breast invasive adenocarcinoma(62;0.14)		TTTACTTGCAGACATCCATTC	0.413			NA											4	111					0	0	0.000248	0	0
MAK	4117	broad.mit.edu	37	6	10764813	10764813	+	Silent	SNP	G	G	T			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr6:10764813G>T	uc003mzl.2	-	13	1973	c.1744C>A	c.(1744-1746)CGG>AGG	p.R582R	SYCP2L_uc011dim.1_Intron|TMEM14B_uc010jos.1_Intron|MAK_uc010jot.2_RNA|MAK_uc010jou.2_RNA|MAK_uc003mzm.2_Silent_p.R582R	NM_005906	NP_005897	P20794	MAK_HUMAN	male germ cell-associated kinase	582					cell differentiation|multicellular organismal development|spermatogenesis		ATP binding|cyclin-dependent protein kinase activity			breast(2)|skin(1)	3	Breast(50;0.107)|Ovarian(93;0.107)	all_hematologic(90;0.117)				AACTGCCCCCGACCAGTTTTT	0.398			NA											30	94					4.3181e-19	7.29565e-19	0.002836	1	0
MYLIP	29116	broad.mit.edu	37	6	16145361	16145361	+	Nonsense_Mutation	SNP	C	C	G			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr6:16145361C>G	uc003nbq.2	+	6	1298	c.1061C>G	c.(1060-1062)TCA>TGA	p.S354*	MYLIP_uc003nbr.2_Nonsense_Mutation_p.S173*	NM_013262	NP_037394	Q8WY64	MYLIP_HUMAN	myosin regulatory light chain interacting	354					cellular component movement|nervous system development	cytoplasm|cytoskeleton|extrinsic to membrane	cytoskeletal protein binding|ubiquitin-protein ligase activity|zinc ion binding			pancreas(1)	1	Breast(50;0.0799)|Ovarian(93;0.103)	all_hematologic(90;0.0895)	Epithelial(50;0.241)			CTGAAGTCCTCAGAAAGCAGC	0.577			NA											17	95					0	0	0.00499	0	0
KIAA0319	9856	broad.mit.edu	37	6	24582479	24582479	+	Missense_Mutation	SNP	G	G	C			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr6:24582479G>C	uc011djo.1	-	6	1426	c.1189C>G	c.(1189-1191)CAA>GAA	p.Q397E	KIAA0319_uc011djp.1_Missense_Mutation_p.Q352E|KIAA0319_uc003neh.1_Missense_Mutation_p.Q397E|KIAA0319_uc011djq.1_Missense_Mutation_p.Q388E|KIAA0319_uc011djr.1_Missense_Mutation_p.Q397E|KIAA0319_uc010jpt.1_5'UTR	NM_014809	NP_055624	Q5VV43	K0319_HUMAN	KIAA0319 precursor	397	PKD 1.|Extracellular (Potential).				negative regulation of dendrite development|neuron migration	early endosome membrane|integral to membrane|plasma membrane	protein binding			ovary(1)|skin(1)	2						TTACTTACTTGAGAGAGGTTA	0.403			NA											9	158					0	0	0.004482	0	0
TRIM10	10107	broad.mit.edu	37	6	30124730	30124730	+	Missense_Mutation	SNP	A	A	G			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr6:30124730A>G	uc003npo.3	-	5	957	c.881T>C	c.(880-882)ATG>ACG	p.M294T	TRIM10_uc003npn.2_Missense_Mutation_p.M294T	NM_006778	NP_006769	Q9UDY6	TRI10_HUMAN	tripartite motif-containing 10 isoform 1	294	B30.2/SPRY.					cytoplasm	zinc ion binding				0						AAACATCTTCATCTCCCTCTG	0.413			NA											11	40					0	0	0.008291	0	0
DEF6	50619	broad.mit.edu	37	6	35280244	35280244	+	Missense_Mutation	SNP	G	G	T			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr6:35280244G>T	uc003okk.2	+	4	628	c.589G>T	c.(589-591)GTG>TTG	p.V197L	DEF6_uc010jvs.2_Missense_Mutation_p.V197L|DEF6_uc010jvt.2_Intron	NM_022047	NP_071330	Q9H4E7	DEFI6_HUMAN	differentially expressed in FDCP 6 homolog	197						cytoplasm|nucleus|plasma membrane					0						CCTGCGGGGCGTGGGCCGGGA	0.657			NA											10	40					1.76689e-08	2.52541e-08	0.006214	1	0
LRFN2	57497	broad.mit.edu	37	6	40400795	40400795	+	Missense_Mutation	SNP	C	C	A	rs149939756		TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr6:40400795C>A	uc003oph.1	-	2	523	c.58G>T	c.(58-60)GCC>TCC	p.A20S		NM_020737	NP_065788	Q9ULH4	LRFN2_HUMAN	leucine rich repeat and fibronectin type III	20						cell junction|integral to membrane|postsynaptic membrane				ovary(2)|skin(1)	3	Ovarian(28;0.0418)|Colorectal(47;0.196)					TTGGGGCAGGCGTCGACCACG	0.602			NA											9	48					7.48243e-07	1.01075e-06	0.006214	1	0
BYSL	705	broad.mit.edu	37	6	41897940	41897940	+	Nonsense_Mutation	SNP	G	G	T			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr6:41897940G>T	uc003orl.2	+	3	838	c.502G>T	c.(502-504)GAG>TAG	p.E168*		NM_004053	NP_004044	Q13895	BYST_HUMAN	bystin	168					cell adhesion|female pregnancy|ribosome biogenesis	cytoplasm|nucleolus					0	Colorectal(47;0.121)		STAD - Stomach adenocarcinoma(11;0.000204)|Epithelial(12;0.000473)|Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)			AGTCATGTCAGAGGTGTCGGG	0.597			NA											8	68					0.00448238	0.00511498	0.004482	1	0
CRISP3	10321	broad.mit.edu	37	6	49698963	49698963	+	Missense_Mutation	SNP	C	C	A			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr6:49698963C>A	uc003ozs.2	-	7	538	c.523G>T	c.(523-525)GGT>TGT	p.G175C		NM_006061	NP_006052	P54108	CRIS3_HUMAN	cysteine-rich secretory protein 3 precursor	175					innate immune response	proteinaceous extracellular matrix|specific granule				skin(2)	2	Lung NSC(77;0.0161)		KIRC - Kidney renal clear cell carcinoma(2;0.106)|Kidney(12;0.156)			GCCCAATTACCACTGAAATTT	0.333			NA											11	70					0.000673444	0.000794103	0.008291	1	0
PAQR8	85315	broad.mit.edu	37	6	52268474	52268474	+	Missense_Mutation	SNP	C	C	G			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr6:52268474C>G	uc003pao.3	+	2	637	c.463C>G	c.(463-465)CAA>GAA	p.Q155E		NM_133367	NP_588608	Q8TEZ7	MPRB_HUMAN	progestin and adipoQ receptor family member	155	Cytoplasmic (Potential).				cell differentiation|multicellular organismal development|oogenesis	integral to membrane|plasma membrane	receptor activity|steroid binding				0	Lung NSC(77;0.0875)					GAGCGTTTACCAATATGGCAG	0.532			NA											11	188					0	0	0.008291	0	0
DST	667	broad.mit.edu	37	6	56765373	56765373	+	Missense_Mutation	SNP	G	G	T			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr6:56765373G>T	uc003pdf.2	-	3	291	c.263C>A	c.(262-264)GCC>GAC	p.A88D		NM_001144769	NP_001138241	Q03001	DYST_HUMAN	dystonin isoform 2	Error:Variant_position_missing_in_Q03001_after_alignment					cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			ovary(7)|central_nervous_system(6)|upper_aerodigestive_tract(1)	14	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			GGCAGCTGCGGCCGCTGCAAC	0.502			NA											20	92					1.01871e-10	1.54998e-10	0.008871	1	0
DDX43	55510	broad.mit.edu	37	6	74123487	74123487	+	Missense_Mutation	SNP	T	T	C			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr6:74123487T>C	uc003pgw.2	+	12	1819	c.1475T>C	c.(1474-1476)GTC>GCC	p.V492A		NM_018665	NP_061135	Q9NXZ2	DDX43_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 43	492	Helicase C-terminal.					intracellular	ATP binding|ATP-dependent RNA helicase activity|RNA binding			ovary(2)|upper_aerodigestive_tract(1)|skin(1)	4						AAAGTCATTGTCTTCGTTTCT	0.323			NA											9	58					0	0	0.001368	0	0
HS3ST5	222537	broad.mit.edu	37	6	114378474	114378474	+	Missense_Mutation	SNP	G	G	C			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr6:114378474G>C	uc003pwg.3	-	2	1020	c.988C>G	c.(988-990)CCT>GCT	p.P330A	uc003pwf.2_Intron|HS3ST5_uc003pwh.3_Missense_Mutation_p.P330A	NM_153612	NP_705840	Q8IZT8	HS3S5_HUMAN	heparan sulfate (glucosamine)	330	Lumenal (Potential).				heparan sulfate proteoglycan biosynthetic process, enzymatic modification|negative regulation of coagulation|protein sulfation|regulation of virion penetration into host cell	Golgi membrane|integral to membrane	3'-phosphoadenosine 5'-phosphosulfate binding|[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity|protein binding			ovary(1)|pancreas(1)	2		all_cancers(87;0.0587)|Colorectal(196;0.0676)|all_epithelial(87;0.154)		OV - Ovarian serous cystadenocarcinoma(136;0.00937)|all cancers(137;0.0117)|Epithelial(106;0.0274)|GBM - Glioblastoma multiforme(226;0.143)		TGATTAAAAGGATGAAAGAAT	0.408			NA											7	72					0	0	0.00308	0	0
RFX6	222546	broad.mit.edu	37	6	117249929	117249929	+	Silent	SNP	T	T	C			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr6:117249929T>C	uc003pxm.2	+	18	2469	c.2406T>C	c.(2404-2406)TAT>TAC	p.Y802Y		NM_173560	NP_775831	Q8HWS3	RFX6_HUMAN	regulatory factor X, 6	802					glucose homeostasis|pancreatic A cell differentiation|pancreatic D cell differentiation|pancreatic E cell differentiation|positive regulation of transcription, DNA-dependent|regulation of insulin secretion|transcription, DNA-dependent|type B pancreatic cell differentiation	nucleus	protein binding|transcription regulatory region DNA binding			ovary(1)|pancreas(1)|skin(1)	3						CAGGATACTATGGAAGCAACA	0.423			NA											7	62					0	0	0.001984	0	0
TMEM200A	114801	broad.mit.edu	37	6	130762164	130762164	+	Silent	SNP	C	C	T			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr6:130762164C>T	uc003qca.2	+	3	1468	c.597C>T	c.(595-597)AGC>AGT	p.S199S	TMEM200A_uc010kfh.2_Silent_p.S199S|TMEM200A_uc010kfi.2_Silent_p.S199S|TMEM200A_uc003qcb.2_Silent_p.S199S	NM_052913	NP_443145	Q86VY9	T200A_HUMAN	transmembrane protein 200A	199	Cytoplasmic (Potential).					integral to membrane				ovary(1)	1				GBM - Glioblastoma multiforme(226;0.0139)|OV - Ovarian serous cystadenocarcinoma(155;0.12)		AGAATGGGAGCTCCTGTGCCT	0.473			NA											7	35					0	0	0.00308	0	0
BCLAF1	9774	broad.mit.edu	37	6	136594278	136594278	+	Missense_Mutation	SNP	A	A	T			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr6:136594278A>T	uc003qgx.1	-	7	2153	c.1900T>A	c.(1900-1902)TCG>ACG	p.S634T	BCLAF1_uc003qgw.1_Missense_Mutation_p.S461T|BCLAF1_uc003qgy.1_Missense_Mutation_p.S632T|BCLAF1_uc011edc.1_RNA|BCLAF1_uc011edd.1_RNA|BCLAF1_uc011ede.1_Missense_Mutation_p.S632T	NM_014739	NP_055554	Q9NYF8	BCLF1_HUMAN	BCL2-associated transcription factor 1 isoform	634					induction of apoptosis|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding			ovary(1)	1	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00226)|OV - Ovarian serous cystadenocarcinoma(155;0.00331)		TTCTGATACGAAGTGAACCGC	0.393	Colon(142;1534 1789 5427 7063 28491)		NA											10	317					0	0	0.008291	0	0
PNLDC1	154197	broad.mit.edu	37	6	160240112	160240112	+	Silent	SNP	C	C	A			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr6:160240112C>A	uc003qsx.1	+	17	1530	c.1359C>A	c.(1357-1359)CTC>CTA	p.L453L	PNLDC1_uc003qsy.1_Silent_p.L464L	NM_173516	NP_775787	Q8NA58	PNDC1_HUMAN	poly(A)-specific ribonuclease (PARN)-like domain	453	Cytoplasmic (Potential).					integral to membrane|nucleus	nucleic acid binding				0		Breast(66;0.00519)|Ovarian(120;0.123)		OV - Ovarian serous cystadenocarcinoma(65;1.55e-18)|BRCA - Breast invasive adenocarcinoma(81;5.87e-06)		TCAGGCGACTCACAAGAAGCC	0.522			NA											12	80					3.07112e-06	4.06134e-06	0.000978	1	0
SLC29A4	222962	broad.mit.edu	37	7	5340083	5340083	+	Missense_Mutation	SNP	G	G	A			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr7:5340083G>A	uc003sod.2	+	10	1401	c.1240G>A	c.(1240-1242)GGC>AGC	p.G414S	SLC29A4_uc003soc.2_Missense_Mutation_p.G414S|SLC29A4_uc003soe.2_Missense_Mutation_p.G400S|SLC29A4_uc010ksw.2_Intron	NM_153247	NP_694979	Q7RTT9	S29A4_HUMAN	solute carrier family 29 (nucleoside	414	Cytoplasmic (Potential).				nucleobase, nucleoside and nucleotide metabolic process	apical plasma membrane|integral to membrane	nucleoside transmembrane transporter activity			liver(1)	1		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0903)|OV - Ovarian serous cystadenocarcinoma(56;2.65e-15)		GGACTGGCGGGGCACCCACCT	0.711			NA											13	58					0	0	0.00245	0	0
DAGLB	221955	broad.mit.edu	37	7	6449551	6449551	+	Missense_Mutation	SNP	G	G	A	rs138713047	by1000genomes	TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr7:6449551G>A	uc003sqa.2	-	15	2106	c.1936C>T	c.(1936-1938)CGG>TGG	p.R646W	DAGLB_uc003spy.2_Missense_Mutation_p.R192W|DAGLB_uc003spz.2_Missense_Mutation_p.R343W|DAGLB_uc011jwt.1_Missense_Mutation_p.R460W|DAGLB_uc011jwu.1_Missense_Mutation_p.R517W|DAGLB_uc003sqb.2_Missense_Mutation_p.R365W|DAGLB_uc003sqc.2_Missense_Mutation_p.R365W|DAGLB_uc011jwv.1_RNA|DAGLB_uc003sqd.3_Missense_Mutation_p.R605W	NM_139179	NP_631918	Q8NCG7	DGLB_HUMAN	diacylglycerol lipase, beta isoform 1	646	Cytoplasmic (Potential).				lipid catabolic process|platelet activation	integral to membrane|plasma membrane	acylglycerol lipase activity|metal ion binding|triglyceride lipase activity			ovary(2)|central_nervous_system(1)	3		Ovarian(82;0.232)		UCEC - Uterine corpus endometrioid carcinoma (126;0.102)		TCCAAGGCCCGCATCAGGATG	0.587			NA											7	78					0	0	0.001984	0	0
AHR	196	broad.mit.edu	37	7	17375401	17375401	+	Missense_Mutation	SNP	G	G	A			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr7:17375401G>A	uc011jxz.1	+	9	1764	c.1151G>A	c.(1150-1152)AGA>AAA	p.R384K	AHR_uc003stt.3_RNA	NM_001621	NP_001612	P35869	AHR_HUMAN	aryl hydrocarbon receptor precursor	384	PAC.				apoptosis|blood vessel development|cell cycle|regulation of B cell proliferation|response to stress|transcription from RNA polymerase II promoter|xenobiotic metabolic process	cytosolic aryl hydrocarbon receptor complex|transcription factor complex	Hsp90 protein binding|ligand-dependent nuclear receptor activity|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription regulatory region DNA binding			urinary_tract(1)|kidney(1)|pancreas(1)	3	Lung NSC(10;0.0392)|all_lung(11;0.0754)					GTAACTCAGAGACCACTAACG	0.353			NA											6	33					0	0	0.004482	0	0
NUPL2	11097	broad.mit.edu	37	7	23221741	23221741	+	Missense_Mutation	SNP	C	C	T			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr7:23221741C>T	uc003svu.2	+	1	296	c.37C>T	c.(37-39)CGC>TGC	p.R13C	NUPL2_uc003svv.2_RNA|NUPL2_uc003svw.2_5'UTR|NUPL2_uc011jyw.1_RNA|NUPL2_uc003svx.2_5'UTR	NM_007342	NP_031368	O15504	NUPL2_HUMAN	nucleoporin like 2	13	C3H1-type.				carbohydrate metabolic process|glucose transport|mRNA transport|protein export from nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear membrane|nuclear pore	nuclear export signal receptor activity|nucleic acid binding|zinc ion binding			skin(2)|ovary(1)	3						AGGCCGGTGCCGCTTTGGAGA	0.602			NA											7	33					0	0	0.001984	0	0
GPNMB	10457	broad.mit.edu	37	7	23299726	23299726	+	Silent	SNP	C	C	T			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr7:23299726C>T	uc003swc.2	+	5	830	c.669C>T	c.(667-669)ATC>ATT	p.I223I	GPNMB_uc003swb.2_Silent_p.I223I|GPNMB_uc011jyy.1_Silent_p.I165I|GPNMB_uc011jyz.1_Silent_p.I124I	NM_001005340	NP_001005340	Q14956	GPNMB_HUMAN	glycoprotein (transmembrane) nmb isoform a	223	Extracellular (Potential).				negative regulation of cell proliferation	melanosome				ovary(3)|breast(2)	5			GBM - Glioblastoma multiforme(13;0.154)			ATGTTCCCATCGCACAAGTGA	0.463			NA											14	124					0	0	0.003163	0	0
OSBPL3	26031	broad.mit.edu	37	7	24874132	24874132	+	Silent	SNP	C	C	A			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr7:24874132C>A	uc003sxf.2	-	15	2124	c.1719G>T	c.(1717-1719)GCG>GCT	p.A573A	OSBPL3_uc003sxd.2_RNA|OSBPL3_uc003sxe.2_RNA|OSBPL3_uc003sxg.2_Silent_p.A537A|OSBPL3_uc003sxh.2_Silent_p.A542A|OSBPL3_uc003sxi.2_Silent_p.A506A|OSBPL3_uc003sxj.1_Silent_p.A302A|OSBPL3_uc003sxk.1_Silent_p.A271A	NM_015550	NP_056365	Q9H4L5	OSBL3_HUMAN	oxysterol-binding protein-like protein 3 isoform	573					lipid transport		lipid binding|protein binding			skin(1)	1						TGGGAATCTGCGCGGCCTTGT	0.647			NA											7	68					8.12818e-05	9.95791e-05	0.001984	1	0
LOC402644	402644	broad.mit.edu	37	7	28319036	28319036	+	Missense_Mutation	SNP	G	G	T			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr7:28319036G>T	uc010kuz.1	-	1	283	c.283C>A	c.(283-285)CCT>ACT	p.P95T		NM_001126493	NP_001119965			hypothetical protein LOC402644												0						AAGATGCCAGGACCTGTACGC	0.488			NA											8	56					0.000157383	0.000190747	0.00308	1	0
HECW1	23072	broad.mit.edu	37	7	43508595	43508595	+	Missense_Mutation	SNP	T	T	A			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr7:43508595T>A	uc003tid.1	+	16	3595	c.2990T>A	c.(2989-2991)TTT>TAT	p.F997Y	HECW1_uc011kbi.1_Missense_Mutation_p.F963Y	NM_015052	NP_055867	Q76N89	HECW1_HUMAN	NEDD4-like ubiquitin-protein ligase 1	997					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	ubiquitin-protein ligase activity			ovary(8)|lung(6)|breast(4)|skin(4)|pancreas(1)	23						GCTCGCAATTTTGAACGCTAC	0.552			NA											9	61					0	0	0.004482	0	0
URGCP	55665	broad.mit.edu	37	7	43927062	43927062	+	Missense_Mutation	SNP	C	C	A			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr7:43927062C>A	uc003tiw.2	-	3	121	c.64G>T	c.(64-66)GCC>TCC	p.A22S	URGCP_uc003tiu.2_5'UTR|URGCP_uc003tiv.2_5'UTR|URGCP_uc003tix.2_Missense_Mutation_p.A13S|URGCP_uc003tiy.2_5'UTR|URGCP_uc003tiz.2_5'UTR|URGCP_uc011kbj.1_5'UTR	NM_001077663	NP_001071131	Q8TCY9	URGCP_HUMAN	up-regulated gene 4 isoform 3	22					cell cycle	centrosome|nucleus	GTP binding			ovary(2)|liver(1)|skin(1)	4						ATTTCTGGGGCTACTTCTCCC	0.363			NA											9	62					2.17888e-05	2.78385e-05	0.006214	1	0
IGFBP1	3484	broad.mit.edu	37	7	45930284	45930284	+	Missense_Mutation	SNP	G	G	C			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr7:45930284G>C	uc003tnp.2	+	2	780	c.487G>C	c.(487-489)GCT>CCT	p.A163P	IGFBP1_uc003tno.3_Missense_Mutation_p.A163P|IGFBP1_uc010kyn.2_Missense_Mutation_p.A163P	NM_000596	NP_000587	P08833	IBP1_HUMAN	insulin-like growth factor binding protein 1	163						extracellular space	insulin-like growth factor binding			lung(1)	1						TGGCTCGAAGGCTCTCCATGT	0.517			NA									OREG0018048	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	21	94					0	0	0.004656	0	0
ZNF479	90827	broad.mit.edu	37	7	57188235	57188235	+	Missense_Mutation	SNP	G	G	T			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr7:57188235G>T	uc010kzo.2	-	5	1158	c.887C>A	c.(886-888)CCC>CAC	p.P296H		NM_033273	NP_150376	Q96JC4	ZN479_HUMAN	zinc finger protein 479	296					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)|skin(1)	4			GBM - Glioblastoma multiforme(1;9.18e-12)			ACATTTGTAGGGTCTCTCTCC	0.473			NA											8	72					0.000442599	0.000528505	0.006214	1	0
WBSCR17	64409	broad.mit.edu	37	7	71036294	71036294	+	Silent	SNP	G	G	T	rs144028983	byFrequency	TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr7:71036294G>T	uc003tvy.2	+	6	987	c.987G>T	c.(985-987)TCG>TCT	p.S329S	WBSCR17_uc003tvz.2_Silent_p.S28S	NM_022479	NP_071924	Q6IS24	GLTL3_HUMAN	UDP-GalNAc:polypeptide	329	Catalytic subdomain B.|Lumenal (Potential).					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding	p.S329L(1)		skin(3)|upper_aerodigestive_tract(1)|ovary(1)|pancreas(1)|central_nervous_system(1)	7		all_cancers(73;0.2)|Lung NSC(55;0.094)|all_lung(88;0.125)				TAGGCTGCTCGTTCGTGGTCA	0.502			NA											11	130					3.07112e-06	4.06134e-06	0.000978	1	0
PCLO	27445	broad.mit.edu	37	7	82538271	82538271	+	Missense_Mutation	SNP	C	C	A			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr7:82538271C>A	uc003uhx.2	-	8	13648	c.13359G>T	c.(13357-13359)TTG>TTT	p.L4453F	PCLO_uc003uhv.2_Missense_Mutation_p.L4453F	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	4384					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						GTCCATTTTCCAAACGAGACT	0.443			NA											13	75					1.36491e-13	2.20726e-13	0.001855	1	0
PCLO	27445	broad.mit.edu	37	7	82584133	82584133	+	Missense_Mutation	SNP	C	C	T			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr7:82584133C>T	uc003uhx.2	-	5	6425	c.6136G>A	c.(6136-6138)GGT>AGT	p.G2046S	PCLO_uc003uhv.2_Missense_Mutation_p.G2046S	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	1977					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						ACCATAGTACCCAGGTCCACT	0.398			NA											5	73					0	0	0.000602	0	0
PCLO	27445	broad.mit.edu	37	7	82764398	82764398	+	Missense_Mutation	SNP	C	C	A			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr7:82764398C>A	uc003uhx.2	-	3	2757	c.2468G>T	c.(2467-2469)CGA>CTA	p.R823L	PCLO_uc003uhv.2_Missense_Mutation_p.R823L	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	769	Pro-rich.				cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						TGATGCAGGTCGAGGTATGGC	0.438			NA											28	204					7.07758e-08	9.94022e-08	0.004656	1	0
SRI	6717	broad.mit.edu	37	7	87837825	87837825	+	Silent	SNP	A	A	G			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr7:87837825A>G	uc003ujq.1	-	7	619	c.567T>C	c.(565-567)GAT>GAC	p.D189D	SRI_uc011khg.1_Silent_p.D149D|SRI_uc003ujr.1_Silent_p.D174D|SRI_uc011khh.1_Silent_p.D174D	NM_003130	NP_003121	P30626	SORCN_HUMAN	sorcin isoform a	189					heart development|intracellular sequestering of iron ion|muscle organ development|regulation of action potential|regulation of heart contraction|regulation of striated muscle contraction|signal transduction	sarcoplasmic reticulum membrane	calcium channel regulator activity|calcium ion binding|receptor binding			upper_aerodigestive_tract(1)	1	Esophageal squamous(14;0.00202)					GACTTACATCATCATATGGGA	0.343			NA											4	39					0	0	0.000248	0	0
ZNF804B	219578	broad.mit.edu	37	7	88847491	88847491	+	Missense_Mutation	SNP	C	C	G			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr7:88847491C>G	uc011khi.1	+	2	669	c.131C>G	c.(130-132)ACA>AGA	p.T44R		NM_181646	NP_857597	A4D1E1	Z804B_HUMAN	zinc finger protein 804B	44						intracellular	zinc ion binding			ovary(5)|skin(3)|pancreas(2)|upper_aerodigestive_tract(1)	11	all_hematologic(106;0.125)|Lung NSC(181;0.15)|all_lung(186;0.151)		STAD - Stomach adenocarcinoma(171;0.0513)			AAGAAGTCCACAGCAAAGGCC	0.343			NA								HNSCC(36;0.09)			8	66					0	0	0.004482	0	0
FBXL13	222235	broad.mit.edu	37	7	102608486	102608486	+	Missense_Mutation	SNP	T	T	A			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr7:102608486T>A	uc003vaq.2	-	7	1001	c.574A>T	c.(574-576)AAC>TAC	p.N192Y	FBXL13_uc010liq.1_Missense_Mutation_p.N7Y|FBXL13_uc010lir.1_Missense_Mutation_p.N192Y|FBXL13_uc003var.2_RNA|FBXL13_uc003vas.2_Missense_Mutation_p.N192Y|FBXL13_uc003vav.2_RNA	NM_145032	NP_659469	Q8NEE6	FXL13_HUMAN	F-box and leucine-rich repeat protein 13 isoform	192	F-box.										0						CACAGTGAGTTTAGTTGTGTC	0.373			NA											8	29					0	0	0.004482	0	0
RELN	5649	broad.mit.edu	37	7	103205757	103205757	+	Silent	SNP	C	C	T			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr7:103205757C>T	uc003vca.2	-	34	5338	c.5178G>A	c.(5176-5178)AAG>AAA	p.K1726K	RELN_uc010liz.2_Silent_p.K1726K	NM_005045	NP_005036	P78509	RELN_HUMAN	reelin isoform a	1726					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			ovary(8)|upper_aerodigestive_tract(5)|large_intestine(2)|central_nervous_system(2)|skin(1)|pancreas(1)	19				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		CAGTGATCCGCTTCCAATTCT	0.438	NSCLC(146;835 1944 15585 22231 52158)		NA											9	91					0	0	0.006214	0	0
RELN	5649	broad.mit.edu	37	7	103338439	103338439	+	Missense_Mutation	SNP	A	A	T			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr7:103338439A>T	uc003vca.2	-	10	1164	c.1004T>A	c.(1003-1005)GTA>GAA	p.V335E	RELN_uc010liz.2_Missense_Mutation_p.V335E	NM_005045	NP_005036	P78509	RELN_HUMAN	reelin isoform a	335					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			ovary(8)|upper_aerodigestive_tract(5)|large_intestine(2)|central_nervous_system(2)|skin(1)|pancreas(1)	19				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		CACTTCACCTACACGAAGATT	0.468	NSCLC(146;835 1944 15585 22231 52158)		NA											12	141					0	0	0.001368	0	0
LAMB1	3912	broad.mit.edu	37	7	107572810	107572810	+	Missense_Mutation	SNP	G	G	T			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr7:107572810G>T	uc003vew.2	-	28	4536	c.4201C>A	c.(4201-4203)CCC>ACC	p.P1401T	LAMB1_uc003vev.2_Missense_Mutation_p.P1425T|LAMB1_uc003veu.2_5'Flank	NM_002291	NP_002282	P07942	LAMB1_HUMAN	laminin, beta 1 precursor	1401	Domain alpha.				axon guidance|odontogenesis|positive regulation of cell migration|positive regulation of epithelial cell proliferation|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-2 complex|laminin-8 complex|perinuclear region of cytoplasm	extracellular matrix structural constituent			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	8					Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GCCCCTGGGGGTGTTCCACAG	0.592			NA											8	64					0.000274275	0.000329596	0.004482	1	0
FOXP2	93986	broad.mit.edu	37	7	114304340	114304340	+	Missense_Mutation	SNP	G	G	C			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr7:114304340G>C	uc003vhb.2	+	16	2226	c.1852G>C	c.(1852-1854)GAG>CAG	p.E618Q	FOXP2_uc003vgu.2_RNA|FOXP2_uc003vgz.2_Missense_Mutation_p.E643Q|FOXP2_uc003vha.2_Missense_Mutation_p.E526Q|FOXP2_uc011kmu.1_Missense_Mutation_p.E635Q|FOXP2_uc011kmv.1_Missense_Mutation_p.E617Q|FOXP2_uc010ljz.1_Missense_Mutation_p.E433Q	NM_014491	NP_055306	O15409	FOXP2_HUMAN	forkhead box P2 isoform I	618					camera-type eye development|caudate nucleus development|cerebellum development|cerebral cortex development|embryo development|growth|lung alveolus development|negative regulation of transcription, DNA-dependent|pattern specification process|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of mesenchymal cell proliferation|post-embryonic development|putamen development|regulation of sequence-specific DNA binding transcription factor activity|righting reflex|skeletal muscle tissue development|smooth muscle tissue development|vocal learning	cytoplasm|transcription factor complex	chromatin binding|DNA bending activity|double-stranded DNA binding|promoter binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|zinc ion binding			ovary(4)|pancreas(1)|lung(1)|breast(1)|skin(1)	8						TGCCTTGGCAGAGAGCAGTTT	0.388			NA											3	37					0	0	0.001168	0	0
CFTR	1080	broad.mit.edu	37	7	117149094	117149094	+	Missense_Mutation	SNP	G	G	T	rs121909025		TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr7:117149094G>T	uc003vjd.2	+	3	303	c.171G>T	c.(169-171)TGG>TGT	p.W57C	CFTR_uc011knq.1_5'UTR	NM_000492	NP_000483	P13569	CFTR_HUMAN	cystic fibrosis transmembrane conductance	57	Cytoplasmic (Potential).		W -> G (in CF).		respiratory gaseous exchange	apical plasma membrane|basolateral plasma membrane|chloride channel complex|early endosome membrane	ATP binding|ATP-binding and phosphorylation-dependent chloride channel activity|channel-conductance-controlling ATPase activity|chloride channel regulator activity|enzyme binding|PDZ domain binding			central_nervous_system(2)|skin(2)|ovary(1)	5	Lung NSC(10;0.00148)|all_lung(10;0.00171)		STAD - Stomach adenocarcinoma(10;0.000534)		Bumetanide(DB00887)|Glibenclamide(DB01016)	GCAGAGAATGGGATAGAGAGC	0.333			NA							Cystic_Fibrosis				11	144					0.000978159	0.00114863	0.000978	1	0
CTTNBP2	83992	broad.mit.edu	37	7	117432096	117432097	+	Missense_Mutation	DNP	CC	CC	AA			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr7:117432096_117432097CC>AA	uc003vjf.2	-	4	1245_1246	c.1153_1154GG>TT	c.(1153-1155)GGA>TTA	p.G385L		NM_033427	NP_219499	Q8WZ74	CTTB2_HUMAN	cortactin binding protein 2	385	Pro-rich.									ovary(4)|central_nervous_system(1)	5	Lung NSC(10;0.0018)|all_lung(10;0.002)			LUSC - Lung squamous cell carcinoma(290;0.133)		AGTGCTTGGTCCATTTTCCTCA	0.55			NA											11	126					0	0	0.004672	0	0
PTPRZ1	5803	broad.mit.edu	37	7	121651876	121651876	+	Missense_Mutation	SNP	C	C	G			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr7:121651876C>G	uc003vjy.2	+	12	3171	c.2776C>G	c.(2776-2778)CCT>GCT	p.P926A	PTPRZ1_uc003vjz.2_Intron|PTPRZ1_uc011knt.1_Intron	NM_002851	NP_002842	P23471	PTPRZ_HUMAN	protein tyrosine phosphatase, receptor-type,	926	Extracellular (Potential).				central nervous system development	integral to plasma membrane	protein binding|protein tyrosine/threonine phosphatase activity|transmembrane receptor protein tyrosine phosphatase activity			ovary(3)|large_intestine(2)|lung(2)|central_nervous_system(1)|kidney(1)	9						AGGGCCTGAACCTTCTTATGC	0.433			NA											17	129					0	0	0.006122	0	0
CPA1	1357	broad.mit.edu	37	7	130027667	130027667	+	Missense_Mutation	SNP	C	C	G			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr7:130027667C>G	uc003vpx.2	+	10	1147	c.1075C>G	c.(1075-1077)CAA>GAA	p.Q359E		NM_001868	NP_001859	P15085	CBPA1_HUMAN	carboxypeptidase A1 precursor	359					proteolysis	extracellular space	metallocarboxypeptidase activity|zinc ion binding			ovary(1)	1	Melanoma(18;0.0435)					TGCCCCAGATCAAGCCAGTGG	0.527			NA											26	397					0	0	0.004656	0	0
PLXNA4	91584	broad.mit.edu	37	7	132192544	132192544	+	Missense_Mutation	SNP	A	A	T			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr7:132192544A>T	uc003vra.3	-	2	1138	c.909T>A	c.(907-909)AGT>AGA	p.S303R	PLXNA4_uc003vrc.2_Missense_Mutation_p.S303R|PLXNA4_uc003vrb.2_Missense_Mutation_p.S303R	NM_020911	NP_065962	Q9HCM2	PLXA4_HUMAN	plexin A4 isoform 1	303	Extracellular (Potential).|Sema.					integral to membrane|intracellular|plasma membrane				ovary(1)	1						ACTCCACCCCACTGCGCTCAC	0.587			NA											8	20					0	0	0.00308	0	0
EXOC4	60412	broad.mit.edu	37	7	133682312	133682312	+	Missense_Mutation	SNP	G	G	C			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr7:133682312G>C	uc003vrk.2	+	15	2309	c.2274G>C	c.(2272-2274)CAG>CAC	p.Q758H	EXOC4_uc011kpo.1_Missense_Mutation_p.Q657H|EXOC4_uc003vrl.2_Missense_Mutation_p.Q368H|EXOC4_uc011kpp.1_Missense_Mutation_p.Q290H|EXOC4_uc011kpq.1_Missense_Mutation_p.Q46H	NM_021807	NP_068579	Q96A65	EXOC4_HUMAN	SEC8 protein isoform a	758					vesicle docking involved in exocytosis	exocyst	protein N-terminus binding			ovary(4)|large_intestine(3)|upper_aerodigestive_tract(1)|skin(1)	9		Esophageal squamous(399;0.129)				AGATCATGCAGACTCTCAGTG	0.493			NA											5	58					0	0	0.001168	0	0
WEE2	494551	broad.mit.edu	37	7	141408876	141408876	+	Silent	SNP	C	C	A			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr7:141408876C>A	uc003vwn.2	+	1	724	c.318C>A	c.(316-318)CCC>CCA	p.P106P	FLJ40852_uc011krh.1_Intron|FLJ40852_uc010lnm.2_Intron|FLJ40852_uc010lnn.2_Intron|FLJ40852_uc003vwm.3_Intron|FLJ40852_uc010lno.2_Intron	NM_001105558	NP_001099028	P0C1S8	WEE2_HUMAN	WEE1 homolog 2	106					egg activation|female meiosis|female pronucleus assembly|meiotic metaphase II|meiotic prophase I|mitosis|negative regulation of oocyte development|regulation of meiosis I	centrosome|nucleus	ATP binding|magnesium ion binding|non-membrane spanning protein tyrosine kinase activity|protein serine/threonine kinase activity			ovary(1)|stomach(1)	2	Melanoma(164;0.0171)					AGCTGCTGCCCAGTGACAGCC	0.522			NA											16	104					3.45872e-05	4.37949e-05	0.004007	1	0
PRSS1	5644	broad.mit.edu	37	7	142458475	142458475	+	Missense_Mutation	SNP	A	A	G			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr7:142458475A>G	uc003wak.2	+	2	127	c.110A>G	c.(109-111)TAC>TGC	p.Y37C	uc011krr.1_Intron|uc003vzp.2_Intron|uc011ksh.1_Intron|uc011ksi.1_Intron|uc003vzw.1_Intron|uc010loj.1_Intron|uc003wad.2_Intron|uc003wag.1_Intron|TRY6_uc011ksn.1_Intron|PRSS1_uc011ksm.1_Intron|PRSS1_uc003wam.2_5'Flank	NM_002769	NP_002760	P07477	TRY1_HUMAN	protease, serine, 1 preproprotein	37	Peptidase S1.				digestion|proteolysis	extracellular space	metal ion binding|protein binding|serine-type endopeptidase activity			large_intestine(1)|central_nervous_system(1)	2	Melanoma(164;0.047)	all_cancers(3;2.14e-49)|Acute lymphoblastic leukemia(3;7.3e-185)|all_hematologic(3;1.1e-165)	all cancers(2;0.000126)|Colorectal(2;0.000157)|Epithelial(2;0.000191)|COAD - Colon adenocarcinoma(2;0.00189)			TCTGTCCCCTACCAGGTGTCC	0.537			NA							Hereditary_Pancreatitis				16	135					0	0	0.003163	0	0
OR2A2	442361	broad.mit.edu	37	7	143807463	143807463	+	Missense_Mutation	SNP	C	C	G			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr7:143807463C>G	uc011ktz.1	+	1	788	c.788C>G	c.(787-789)TCT>TGT	p.S263C		NM_001005480	NP_001005480	Q6IF42	OR2A2_HUMAN	olfactory receptor, family 2, subfamily A,	263	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2	Melanoma(164;0.0783)					GTCCCAGACTCTAATCAACGA	0.507			NA											26	192					0	0	0.002096	0	0
MLL3	58508	broad.mit.edu	37	7	151945170	151945170	+	Silent	SNP	G	G	C			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr7:151945170G>C	uc003wla.2	-	14	2568	c.2349C>G	c.(2347-2349)TCC>TCG	p.S783S		NM_170606	NP_733751	Q8NEZ4	MLL3_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 3	783					intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			large_intestine(27)|pancreas(13)|ovary(9)|central_nervous_system(8)|breast(3)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	63	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)		GTGTTGGGGAGGAAGACACAT	0.423	Colon(68;14 1149 1884 27689 34759)		NA	N		medulloblastoma								9	496					0	0	0.008291	0	0
MYOM2	9172	broad.mit.edu	37	8	2088653	2088653	+	Nonsense_Mutation	SNP	A	A	T	rs76960308	by1000genomes	TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr8:2088653A>T	uc003wpx.3	+	33	3946	c.3808A>T	c.(3808-3810)AAG>TAG	p.K1270*	MYOM2_uc011kwi.1_Nonsense_Mutation_p.K695*	NM_003970	NP_003961	P54296	MYOM2_HUMAN	myomesin 2	1270					muscle contraction	myosin filament	structural constituent of muscle			ovary(4)|central_nervous_system(1)|skin(1)	6		Ovarian(12;0.0572)|Colorectal(14;0.0844)|Hepatocellular(245;0.217)		BRCA - Breast invasive adenocarcinoma(11;1.85e-05)|Colorectal(4;0.0101)|READ - Rectum adenocarcinoma(4;0.148)|COAD - Colon adenocarcinoma(4;0.179)		AAGAGATGCTAAGATCTCATC	0.473			NA											7	54					0	0	0.00308	0	0
RP1L1	94137	broad.mit.edu	37	8	10467736	10467736	+	Missense_Mutation	SNP	T	T	A			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr8:10467736T>A	uc003wtc.2	-	4	4101	c.3872A>T	c.(3871-3873)CAG>CTG	p.Q1291L		NM_178857	NP_849188	Q8IWN7	RP1L1_HUMAN	retinitis pigmentosa 1-like 1	1291					intracellular signal transduction					ovary(4)|breast(3)|central_nervous_system(1)	8				COAD - Colon adenocarcinoma(149;0.0811)		TTCAGCTAACTGCTCCAGGTT	0.383			NA											16	140					0	0	0.004007	0	0
TEX15	56154	broad.mit.edu	37	8	30705192	30705192	+	Missense_Mutation	SNP	C	C	T			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr8:30705192C>T	uc003xil.2	-	1	1342	c.1342G>A	c.(1342-1344)GAA>AAA	p.E448K		NM_031271	NP_112561	Q9BXT5	TEX15_HUMAN	testis expressed 15	448										ovary(3)|upper_aerodigestive_tract(2)|skin(2)	7				KIRC - Kidney renal clear cell carcinoma(542;0.0918)|Kidney(114;0.111)		CCCCTATCTTCAACATAAGCA	0.333			NA											27	194					0	0	0.00632	0	0
DDHD2	23259	broad.mit.edu	37	8	38110567	38110567	+	Missense_Mutation	SNP	C	C	G			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr8:38110567C>G	uc003xlb.2	+	15	2190	c.1813C>G	c.(1813-1815)CCA>GCA	p.P605A	DDHD2_uc003xlc.2_Missense_Mutation_p.P605A|DDHD2_uc003xld.2_Missense_Mutation_p.P224A	NM_015214	NP_056029	O94830	DDHD2_HUMAN	DDHD domain containing 2 isoform 1	605	DDHD.				lipid catabolic process	centrosome	hydrolase activity|metal ion binding			large_intestine(1)|ovary(1)	2	Colorectal(12;0.000442)	all_lung(54;0.0657)|Lung NSC(58;0.175)	BRCA - Breast invasive adenocarcinoma(5;3.76e-25)|COAD - Colon adenocarcinoma(9;0.0977)			TACCAGAGCTCCATACCCTGC	0.473			NA											4	41					0	0	0.000248	0	0
CYP7A1	1581	broad.mit.edu	37	8	59409192	59409192	+	Silent	SNP	C	C	A			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr8:59409192C>A	uc003xtm.3	-	3	942	c.879G>T	c.(877-879)GCG>GCT	p.A293A		NM_000780	NP_000771	P22680	CP7A1_HUMAN	cytochrome P450, family 7, subfamily A,	293					bile acid biosynthetic process|cellular lipid metabolic process|cellular response to cholesterol|cellular response to glucose stimulus|cholesterol catabolic process|cholesterol homeostasis|regulation of bile acid biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	cholesterol 7-alpha-monooxygenase activity|electron carrier activity|heme binding			ovary(1)	1		all_lung(136;0.0271)|Lung NSC(129;0.0351)|all_epithelial(80;0.0554)				TCCAGAAAGTCGCTGGAATGG	0.388			NA							Neonatal_Giant_Cell_Hepatitis				8	82					1.06961e-07	1.49482e-07	0.00308	1	0
PREX2	80243	broad.mit.edu	37	8	68992817	68992817	+	Silent	SNP	A	A	G			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr8:68992817A>G	uc003xxv.1	+	16	1809	c.1782A>G	c.(1780-1782)TTA>TTG	p.L594L	PREX2_uc003xxu.1_Silent_p.L594L|PREX2_uc011lez.1_Silent_p.L529L	NM_024870	NP_079146	Q70Z35	PREX2_HUMAN	DEP domain containing 2 isoform a	594	PDZ 1.				G-protein coupled receptor protein signaling pathway|intracellular signal transduction	intracellular	protein binding|Rac GTPase activator activity|Rac guanyl-nucleotide exchange factor activity			skin(6)|large_intestine(4)|pancreas(3)|lung(2)|ovary(1)|kidney(1)	17						CTAAGTCATTATTGGTAAGTT	0.328			NA											4	38					0	0	0.000248	0	0
KCNS2	3788	broad.mit.edu	37	8	99440470	99440470	+	Missense_Mutation	SNP	G	G	A			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr8:99440470G>A	uc003yin.2	+	2	613	c.263G>A	c.(262-264)GGC>GAC	p.G88D		NM_020697	NP_065748	Q9ULS6	KCNS2_HUMAN	potassium voltage-gated channel,	88	Cytoplasmic (Potential).					voltage-gated potassium channel complex	voltage-gated potassium channel activity			ovary(1)	1	Breast(36;2.4e-06)		OV - Ovarian serous cystadenocarcinoma(57;0.0448)			TATCACACCGGCAAGCTTCAC	0.542	Pancreas(138;844 2489 9202 24627)		NA											4	105					0	0	0.000248	0	0
VPS13B	157680	broad.mit.edu	37	8	100479783	100479783	+	Missense_Mutation	SNP	G	G	A			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr8:100479783G>A	uc003yiv.2	+	24	3698	c.3587G>A	c.(3586-3588)GGA>GAA	p.G1196E	VPS13B_uc003yiw.2_Missense_Mutation_p.G1196E|VPS13B_uc003yiu.1_Missense_Mutation_p.G1196E|VPS13B_uc003yix.1_Missense_Mutation_p.G666E	NM_017890	NP_060360	Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13B isoform 5	1196					protein transport					ovary(7)|skin(4)|lung(3)|central_nervous_system(2)|pancreas(2)|breast(1)|kidney(1)	20	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			CTTGCTACGGGACCTGATACA	0.428	Colon(161;2205 2542 7338 31318)		NA											17	152					0	0	0.00499	0	0
ZFPM2	23414	broad.mit.edu	37	8	106811100	106811100	+	Missense_Mutation	SNP	C	C	A			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr8:106811100C>A	uc003ymd.2	+	7	911	c.888C>A	c.(886-888)AGC>AGA	p.S296R	ZFPM2_uc011lhs.1_Missense_Mutation_p.S27R|uc003yme.1_5'Flank	NM_012082	NP_036214	Q8WW38	FOG2_HUMAN	zinc finger protein, multitype 2	296	C2H2-type 1.				blood coagulation|negative regulation of fat cell differentiation|outflow tract septum morphogenesis|right ventricular cardiac muscle tissue morphogenesis|ventricular septum morphogenesis	nucleoplasm	DNA binding|RNA polymerase II transcription coactivator activity|transcription corepressor activity|transcription factor binding|zinc ion binding			ovary(4)|large_intestine(1)	5			OV - Ovarian serous cystadenocarcinoma(57;8.28e-08)			AGATTTCCAGCCTGTGCCCCT	0.493			NA											9	120					5.4927e-09	8.01255e-09	0.004482	1	0
CSMD3	114788	broad.mit.edu	37	8	113348905	113348905	+	Missense_Mutation	SNP	G	G	T			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr8:113348905G>T	uc003ynu.2	-	44	7154	c.6995C>A	c.(6994-6996)CCA>CAA	p.P2332Q	CSMD3_uc003yns.2_Missense_Mutation_p.P1534Q|CSMD3_uc003ynt.2_Missense_Mutation_p.P2292Q|CSMD3_uc011lhx.1_Missense_Mutation_p.P2228Q|CSMD3_uc003ynw.1_Missense_Mutation_p.P43Q	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	2332	Extracellular (Potential).|CUB 13.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						ATCATATATTGGTTCTGTTTG	0.313			NA								HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			10	114					5.50884e-06	7.16782e-06	0.001368	1	0
RHPN1	114822	broad.mit.edu	37	8	144464814	144464814	+	Missense_Mutation	SNP	G	G	T			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr8:144464814G>T	uc003yyb.2	+	15	2139	c.2006G>T	c.(2005-2007)TGG>TTG	p.W669L		NM_052924	NP_443156	Q8TCX5	RHPN1_HUMAN	rhophilin 1	694					signal transduction	intracellular				large_intestine(1)	1	all_cancers(97;7.39e-11)|all_epithelial(106;5.44e-09)|Lung NSC(106;0.000167)|all_lung(105;0.000459)|Ovarian(258;0.0212)|Acute lymphoblastic leukemia(118;0.155)		Colorectal(110;0.107)|BRCA - Breast invasive adenocarcinoma(115;0.156)			CACCCAGGGTGGCCGTGAGGG	0.682			NA											3	21					6.4e-05	7.91091e-05	0.004672	1	0
JAK2	3717	broad.mit.edu	37	9	5029787	5029787	+	Silent	SNP	C	C	T	rs139093384	by1000genomes	TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr9:5029787C>T	uc010mhm.2	+	3	344	c.231C>T	c.(229-231)ATC>ATT	p.I77I	JAK2_uc003ziw.2_Silent_p.I77I	NM_004972	NP_004963	O60674	JAK2_HUMAN	Janus kinase 2	77	Interaction with cytokine/interferon/growth hormone receptors (By similarity).|FERM.				actin filament polymerization|activation of caspase activity by protein phosphorylation|activation of JAK2 kinase activity|blood coagulation|cellular component movement|erythrocyte differentiation|interferon-gamma-mediated signaling pathway|interleukin-12-mediated signaling pathway|JAK-STAT cascade involved in growth hormone signaling pathway|mammary gland epithelium development|mesoderm development|negative regulation of cell proliferation|negative regulation of DNA binding|positive regulation of apoptosis|positive regulation of cell-substrate adhesion|positive regulation of growth hormone receptor signaling pathway|positive regulation of nitric-oxide synthase 2 biosynthetic process|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of tumor necrosis factor production|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of tyrosine phosphorylation of Stat5 protein|protein autophosphorylation|regulation of inflammatory response|regulation of interferon-gamma-mediated signaling pathway|response to antibiotic|response to lipopolysaccharide|STAT protein import into nucleus|tumor necrosis factor-mediated signaling pathway|tyrosine phosphorylation of STAT protein	caveola|cytoskeleton|cytosol|endomembrane system|nucleus	ATP binding|growth hormone receptor binding|heme binding|histone binding|histone kinase activity (H3-Y41 specific)|interleukin-12 receptor binding|non-membrane spanning protein tyrosine kinase activity|protein kinase binding|SH2 domain binding		PCM1/JAK2(30)|PAX5/JAK2(18)|ETV6/JAK2(11)|BCR/JAK2(6)|SSBP2/JAK2(4)|SEC31A/JAK2(4)	haematopoietic_and_lymphoid_tissue(28629)|lung(5)|breast(5)|ovary(1)|liver(1)	28641	all_hematologic(13;0.137)	Acute lymphoblastic leukemia(23;0.0198)|Breast(48;0.147)		GBM - Glioblastoma multiforme(50;0.0237)|Lung(218;0.133)		TTCTAGGTATCACACCTGTGT	0.343			1	T|Mis|O	ETV6|PCM1|BCR	ALL|AML|MPD| CML				Polycythemia_Vera_Familial				5	114					0	0	0.000602	0	0
PDCD1LG2	80380	broad.mit.edu	37	9	5534886	5534886	+	Missense_Mutation	SNP	C	C	A			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr9:5534886C>A	uc003zjg.3	+	3	470	c.197C>A	c.(196-198)ACA>AAA	p.T66K	C9orf46_uc003zjd.2_Intron|PDCD1LG2_uc011lmc.1_Missense_Mutation_p.T66K|PDCD1LG2_uc011lmd.1_Missense_Mutation_p.T66K|PDCD1LG2_uc010mhp.1_Missense_Mutation_p.T66K|PDCD1LG2_uc010mho.1_Missense_Mutation_p.T66K	NM_025239	NP_079515	Q9BQ51	PD1L2_HUMAN	programmed cell death 1 ligand 2 precursor	66	Ig-like V-type.|Extracellular (Potential).				immune response|T cell costimulation	endomembrane system|extracellular region|integral to membrane|plasma membrane	receptor activity				0	all_hematologic(13;0.158)	Acute lymphoblastic leukemia(23;0.154)		GBM - Glioblastoma multiforme(50;0.000767)|Lung(218;0.112)		GAAAATGATACATCCCCACAC	0.517			NA											3	56					2.56e-06	3.40932e-06	0.000248	1	0
ZNF658	26149	broad.mit.edu	37	9	40774879	40774879	+	Silent	SNP	T	T	A			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr9:40774879T>A	uc004abs.2	-	5	548	c.396A>T	c.(394-396)TCA>TCT	p.S132S	ZNF658_uc010mmm.1_Silent_p.S132S|ZNF658_uc010mmn.1_Silent_p.S132S	NM_033160	NP_149350	Q5TYW1	ZN658_HUMAN	zinc finger protein 658	132					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1				GBM - Glioblastoma multiforme(29;0.02)|Lung(182;0.0681)		ATATTTTTTCTGAAAGCTCTG	0.318			NA											3	56					0	0	0.000602	0	0
FAM75A6	389730	broad.mit.edu	37	9	43625471	43625471	+	Missense_Mutation	SNP	C	C	T			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr9:43625471C>T	uc011lrb.1	-	4	3245	c.3216G>A	c.(3214-3216)ATG>ATA	p.M1072I		NM_001145196	NP_001138668	Q5VVP1	F75A6_HUMAN	hypothetical protein LOC389730	1072						integral to membrane					0						TTCTGGCTGCCATGAGGTCAT	0.542			NA											25	294					0	0	0.004656	0	0
ZCCHC6	79670	broad.mit.edu	37	9	88967669	88967669	+	Missense_Mutation	SNP	C	C	T			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr9:88967669C>T	uc004aoq.2	-	2	661	c.446G>A	c.(445-447)AGA>AAA	p.R149K	ZCCHC6_uc011ltf.1_RNA|ZCCHC6_uc004aor.2_RNA|ZCCHC6_uc004aos.2_RNA|ZCCHC6_uc004aot.2_Missense_Mutation_p.R149K|ZCCHC6_uc004aou.2_Missense_Mutation_p.R149K|ZCCHC6_uc004aov.2_Missense_Mutation_p.R149K|ZCCHC6_uc004aow.2_Missense_Mutation_p.R149K|ZCCHC6_uc010mqf.1_Missense_Mutation_p.R149K	NM_024617	NP_078893	Q5VYS8	TUT7_HUMAN	zinc finger, CCHC domain containing 6	149					RNA 3'-end processing		nucleic acid binding|RNA uridylyltransferase activity|zinc ion binding			ovary(2)	2						TCTTACAGTTCTGCAGCCTCT	0.408			NA											15	169					0	0	0.00245	0	0
ZCCHC6	79670	broad.mit.edu	37	9	88967678	88967678	+	Missense_Mutation	SNP	C	C	T			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr9:88967678C>T	uc004aoq.2	-	2	652	c.437G>A	c.(436-438)AGA>AAA	p.R146K	ZCCHC6_uc011ltf.1_RNA|ZCCHC6_uc004aor.2_RNA|ZCCHC6_uc004aos.2_RNA|ZCCHC6_uc004aot.2_Missense_Mutation_p.R146K|ZCCHC6_uc004aou.2_Missense_Mutation_p.R146K|ZCCHC6_uc004aov.2_Missense_Mutation_p.R146K|ZCCHC6_uc004aow.2_Missense_Mutation_p.R146K|ZCCHC6_uc010mqf.1_Missense_Mutation_p.R146K	NM_024617	NP_078893	Q5VYS8	TUT7_HUMAN	zinc finger, CCHC domain containing 6	146					RNA 3'-end processing		nucleic acid binding|RNA uridylyltransferase activity|zinc ion binding			ovary(2)	2						TCTGCAGCCTCTTGTGTCTTG	0.408			NA											18	180					0	0	0.00499	0	0
IARS	3376	broad.mit.edu	37	9	94985761	94985761	+	Silent	SNP	G	G	A			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr9:94985761G>A	uc004art.1	-	32	3677	c.3420C>T	c.(3418-3420)AAC>AAT	p.N1140N	IARS_uc004ars.1_Intron|IARS_uc004aru.3_Silent_p.N1140N|IARS_uc010mqr.2_Silent_p.N1030N|IARS_uc010mqt.2_Silent_p.N363N	NM_013417	NP_038203	P41252	SYIC_HUMAN	isoleucine tRNA synthetase	1140					isoleucyl-tRNA aminoacylation	cytosol|nucleus|soluble fraction	ATP binding|isoleucine-tRNA ligase activity|protein binding			ovary(1)|skin(1)	2					L-Isoleucine(DB00167)	AGTCAGTTTGGTTTTGTATTT	0.338			NA											5	65					0	0	0.000602	0	0
CORO2A	7464	broad.mit.edu	37	9	100893276	100893276	+	Silent	SNP	G	G	A			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr9:100893276G>A	uc004ayl.2	-	7	1097	c.831C>T	c.(829-831)TTC>TTT	p.F277F	CORO2A_uc004aym.2_Silent_p.F277F	NM_003389	NP_003380	Q92828	COR2A_HUMAN	coronin, actin binding protein, 2A	277	WD 5.				actin cytoskeleton organization|intracellular signal transduction	actin cytoskeleton|transcriptional repressor complex	actin filament binding			skin(2)|ovary(1)|pancreas(1)	4		Acute lymphoblastic leukemia(62;0.0559)				CCGCGTCATAGAAGGGAAACA	0.647			NA											3	23					0	0	0.000248	0	0
PTPN3	5774	broad.mit.edu	37	9	112166750	112166750	+	Missense_Mutation	SNP	C	C	A			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr9:112166750C>A	uc004bed.2	-	19	2043	c.1931G>T	c.(1930-1932)GGG>GTG	p.G644V	PTPN3_uc004beb.2_Missense_Mutation_p.G513V|PTPN3_uc004bec.2_Missense_Mutation_p.G468V|PTPN3_uc010mtu.2_RNA|PTPN3_uc011lwg.1_Missense_Mutation_p.G599V|PTPN3_uc011lwh.1_Missense_Mutation_p.G490V|PTPN3_uc011lwd.1_Missense_Mutation_p.G112V|PTPN3_uc011lwe.1_Missense_Mutation_p.G357V|PTPN3_uc011lwf.1_Missense_Mutation_p.G312V	NM_002829	NP_002820	P26045	PTN3_HUMAN	protein tyrosine phosphatase, non-receptor type	644					negative regulation of membrane protein ectodomain proteolysis|negative regulation of mitotic cell cycle	cytoplasm|cytoskeleton|internal side of plasma membrane	ATPase binding|cytoskeletal protein binding|phosphotyrosine binding|protein tyrosine phosphatase activity			ovary(3)	3						CAGCACCGTCCCGCTTTCGAG	0.507			NA											14	59					0.000151284	0.000184541	0.001855	1	0
PALM2-AKAP2	445815	broad.mit.edu	37	9	112900009	112900009	+	Missense_Mutation	SNP	G	G	A			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr9:112900009G>A	uc004bei.2	+	9	3073	c.2881G>A	c.(2881-2883)GAC>AAC	p.D961N	PALM2-AKAP2_uc004bek.3_Missense_Mutation_p.D729N|PALM2-AKAP2_uc004bej.3_Missense_Mutation_p.D729N|PALM2-AKAP2_uc004bel.1_Missense_Mutation_p.D539N|AKAP2_uc011lwi.1_Missense_Mutation_p.D587N|AKAP2_uc004bem.2_Missense_Mutation_p.D587N|PALM2-AKAP2_uc010mtw.1_Missense_Mutation_p.D547N|AKAP2_uc011lwj.1_Missense_Mutation_p.D498N|PALM2-AKAP2_uc004ben.2_Missense_Mutation_p.D498N	NM_001136562	NP_001130034	Q9Y2D5	AKAP2_HUMAN	A kinase (PRKA) anchor protein 2 isoform 2	498							enzyme binding			ovary(3)|central_nervous_system(2)|skin(1)	6						TTTCAGCATGGACAACATCAG	0.507			NA											20	89					0	0	0.001523	0	0
SVEP1	79987	broad.mit.edu	37	9	113194251	113194251	+	Missense_Mutation	SNP	C	C	A			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr9:113194251C>A	uc010mtz.2	-	32	5634	c.5297G>T	c.(5296-5298)GGA>GTA	p.G1766V	SVEP1_uc010mty.2_5'Flank	NM_153366	NP_699197	Q4LDE5	SVEP1_HUMAN	polydom	1766	EGF-like 7; calcium-binding (Potential).				cell adhesion	cytoplasm|extracellular region|membrane	calcium ion binding			ovary(7)	7						TATGTAGGATCCATCTACGTT	0.378			NA											23	95					2.98393e-07	4.08936e-07	0.00278	1	0
ZNF483	158399	broad.mit.edu	37	9	114289741	114289741	+	Silent	SNP	G	G	T			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr9:114289741G>T	uc004bff.2	+	2	290	c.66G>T	c.(64-66)TCG>TCT	p.S22S	ZNF483_uc011lwq.1_Silent_p.S22S|ZNF483_uc004bfg.2_Silent_p.S22S|ZNF483_uc010mud.1_Silent_p.S22S	NM_133464	NP_597721	Q8TF39	ZN483_HUMAN	zinc finger protein 483 isoform a	22					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(1)	1						CTCTGGCCTCGACTGAACAAA	0.478			NA											7	87					2.7689e-08	3.92781e-08	0.001984	1	0
RNF183	138065	broad.mit.edu	37	9	116060272	116060272	+	Missense_Mutation	SNP	G	G	T			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr9:116060272G>T	uc004bgz.2	-	2	311	c.193C>A	c.(193-195)CTG>ATG	p.L65M	RNF183_uc004bha.2_Missense_Mutation_p.L65M	NM_145051	NP_659488	Q96D59	RN183_HUMAN	ring finger protein 183	65						integral to membrane	zinc ion binding				0						CCTGAGGCCAGCACTGTGGGC	0.657			NA											11	50					1.08611e-07	1.51041e-07	0.000978	1	0
ASTN2	23245	broad.mit.edu	37	9	119858343	119858343	+	Missense_Mutation	SNP	C	C	G			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr9:119858343C>G	uc004bjs.1	-	5	1357	c.1256G>C	c.(1255-1257)CGC>CCC	p.R419P	ASTN2_uc004bjr.1_Missense_Mutation_p.R419P|ASTN2_uc004bjt.1_Missense_Mutation_p.R368P	NM_198187	NP_937830	O75129	ASTN2_HUMAN	astrotactin 2 isoform c	419	Cytoplasmic (Potential).					integral to membrane				skin(4)|ovary(3)|breast(1)|kidney(1)	9						GCGGCGACTGCGGTACTGCTC	0.507			NA											5	60					0	0	0.001168	0	0
DBC1	1620	broad.mit.edu	37	9	122075514	122075514	+	Missense_Mutation	SNP	C	C	A			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr9:122075514C>A	uc004bkc.2	-	2	576	c.120G>T	c.(118-120)TGG>TGT	p.W40C	DBC1_uc004bkd.2_Missense_Mutation_p.W40C	NM_014618	NP_055433	O60477	DBC1_HUMAN	deleted in bladder cancer 1 precursor	40					cell cycle arrest|cell death	cytoplasm	protein binding			skin(3)|ovary(2)|central_nervous_system(2)|large_intestine(1)	8						CTGAAATGAGCCAATCAAATT	0.488			NA											16	63					9.95505e-16	1.63795e-15	0.002299	1	0
GOLGA2	2801	broad.mit.edu	37	9	131019541	131019541	+	Silent	SNP	G	G	A			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr9:131019541G>A	uc011maw.1	-	26	2827	c.2814C>T	c.(2812-2814)CTC>CTT	p.L938L	GOLGA2_uc010mxw.2_Silent_p.L261L|GOLGA2_uc004buh.2_Intron	NM_004486	NP_004477	Q08379	GOGA2_HUMAN	Golgi autoantigen, golgin subfamily a, 2	938						Golgi cisterna membrane	protein binding			ovary(1)	1						CACTGCCGGCGAGGCTCACCT	0.637			NA											6	47					0	0	0.001168	0	0
C9orf119	375757	broad.mit.edu	37	9	131050954	131050954	+	Missense_Mutation	SNP	A	A	G			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr9:131050954A>G	uc004bup.2	+	5	667	c.667A>G	c.(667-669)AAA>GAA	p.K223E		NM_001040011	NP_001035100	Q1ZZU3	SWI5_HUMAN	hypothetical protein LOC375757	223					double-strand break repair via homologous recombination	Swi5-Sfr1 complex	protein binding				0						TGTCACCACCAAAGAGTTGTA	0.557			NA											16	172					0	0	0.008871	0	0
ODF2	4957	broad.mit.edu	37	9	131246279	131246279	+	Missense_Mutation	SNP	G	G	T			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr9:131246279G>T	uc011mbd.1	+	11	1361	c.1050G>T	c.(1048-1050)CAG>CAT	p.Q350H	ODF2_uc011maz.1_Missense_Mutation_p.Q350H|ODF2_uc011mba.1_Missense_Mutation_p.Q135H|ODF2_uc010myb.2_Missense_Mutation_p.Q326H|ODF2_uc011mbb.1_Missense_Mutation_p.Q284H|ODF2_uc011mbc.1_Missense_Mutation_p.Q269H|ODF2_uc004bva.2_Missense_Mutation_p.Q303H|ODF2_uc004bvb.2_Missense_Mutation_p.Q326H|ODF2_uc011mbe.1_Missense_Mutation_p.Q345H|ODF2_uc004bvc.2_Missense_Mutation_p.Q326H|ODF2_uc010myc.2_Missense_Mutation_p.Q293H|ODF2_uc011mbf.1_Missense_Mutation_p.Q331H|ODF2_uc004bvd.3_Missense_Mutation_p.Q350H|ODF2_uc004bve.2_Missense_Mutation_p.Q331H|uc004bvg.2_5'Flank	NM_002540	NP_002531	Q5BJF6	ODFP2_HUMAN	outer dense fiber of sperm tails 2 isoform 1	350	Potential.				cell differentiation|G2/M transition of mitotic cell cycle|multicellular organismal development|spermatogenesis	centriole|cilium|cytosol|microtubule|spindle pole	protein binding|structural molecule activity			ovary(1)	1						GGCATTTGCAGGCACAGCTTC	0.527			NA											8	80					2.74318e-10	4.11841e-10	0.006214	1	0
CCBL1	883	broad.mit.edu	37	9	131597812	131597812	+	Missense_Mutation	SNP	C	C	G			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr9:131597812C>G	uc004bwh.2	-	10	1175	c.990G>C	c.(988-990)AAG>AAC	p.K330N	CCBL1_uc004bwf.2_Missense_Mutation_p.K364N|CCBL1_uc004bwg.2_RNA|CCBL1_uc010myn.2_Missense_Mutation_p.K330N|CCBL1_uc004bwj.2_Missense_Mutation_p.K280N|CCBL1_uc011mbl.1_Missense_Mutation_p.K424N|CCBL1_uc004bwi.2_RNA|CCBL1_uc010myo.2_Missense_Mutation_p.K287N	NM_004059	NP_004050	Q16773	KAT1_HUMAN	kynurenine aminotransferase I isoform a	330					kynurenine metabolic process|L-phenylalanine catabolic process|tryptophan catabolic process	cytosol|nucleus	1-aminocyclopropane-1-carboxylate synthase activity|cysteine-S-conjugate beta-lyase activity|glutamine-phenylpyruvate transaminase activity|kynurenine-oxoglutarate transaminase activity|L-glutamine:pyruvate aminotransferase activity|L-phenylalanine:pyruvate aminotransferase activity|protein homodimerization activity|pyridoxal phosphate binding			ovary(1)	1					L-Glutamine(DB00130)|Pyridoxal Phosphate(DB00114)	GGATGATGGGCTTCAGGCCCA	0.602			NA											4	108					0	0	0.000248	0	0
NUP188	23511	broad.mit.edu	37	9	131735483	131735483	+	Silent	SNP	T	T	C			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr9:131735483T>C	uc004bws.1	+	12	1180	c.1158T>C	c.(1156-1158)TCT>TCC	p.S386S		NM_015354	NP_056169	Q5SRE5	NU188_HUMAN	nucleoporin 188kDa	386					carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear pore	protein binding			ovary(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)|kidney(1)|breast(1)	7						GACTGCTCTCTTTCGTTCTGA	0.502			NA											4	63					0	0	0.000602	0	0
NUP214	8021	broad.mit.edu	37	9	134073026	134073026	+	Missense_Mutation	SNP	A	A	T			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr9:134073026A>T	uc004cag.2	+	29	4256	c.4145A>T	c.(4144-4146)AAG>ATG	p.K1382M	NUP214_uc004cah.2_Missense_Mutation_p.K1372M|NUP214_uc004cai.2_Missense_Mutation_p.K812M|NUP214_uc010mzg.2_RNA|NUP214_uc011mcg.1_Missense_Mutation_p.K208M|NUP214_uc011mcf.1_Missense_Mutation_p.K159M|NUP214_uc010mzh.1_Translation_Start_Site|NUP214_uc010mzi.1_Translation_Start_Site	NM_005085	NP_005076	P35658	NU214_HUMAN	nucleoporin 214kDa	1382	Pro/Ser/Thr-rich.|11 X 5 AA approximate repeats.				carbohydrate metabolic process|glucose transport|mRNA metabolic process|protein export from nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear pore|nucleoplasm	protein binding			breast(7)|lung(3)|skin(3)|ovary(2)|central_nervous_system(1)	16	all_hematologic(7;0.0028)	Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;3.42e-05)|Epithelial(140;0.000256)		GTGTTAGGGAAGCACACGGAG	0.562	Pancreas(4;24 48 25510 30394 32571)		NA	T	DEK|SET|ABL1	AML|T-ALL								15	72					0	0	0.00499	0	0
TTF1	7270	broad.mit.edu	37	9	135266077	135266077	+	Missense_Mutation	SNP	G	G	A			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr9:135266077G>A	uc004cbl.2	-	7	2181	c.2129C>T	c.(2128-2130)TCA>TTA	p.S710L	TTF1_uc011mcp.1_RNA|TTF1_uc004cbm.2_Missense_Mutation_p.S195L	NM_007344	NP_031370	Q15361	TTF1_HUMAN	transcription termination factor, RNA polymerase	710	Myb-like 2.				negative regulation of DNA replication|regulation of transcription, DNA-dependent|termination of RNA polymerase I transcription	nucleolus|nucleoplasm	DNA binding			ovary(2)|upper_aerodigestive_tract(1)|pancreas(1)	4		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;4.25e-06)|Epithelial(140;9.09e-05)		CCGAACAATTGATAGGCAACT	0.403			NA											8	244					0	0	0.004482	0	0
CEL	1056	broad.mit.edu	37	9	135942538	135942538	+	Missense_Mutation	SNP	A	A	T			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr9:135942538A>T	uc010naa.1	+	7	866	c.850A>T	c.(850-852)ACT>TCT	p.T284S		NM_001807	NP_001798	P19835	CEL_HUMAN	carboxyl ester lipase precursor	281					cholesterol catabolic process|fatty acid catabolic process|intestinal cholesterol absorption|intestinal lipid catabolic process|pancreatic juice secretion|protein esterification	cytosol|extracellular space	acylglycerol lipase activity|carboxylesterase activity|heparin binding|sterol esterase activity|triglyceride lipase activity			pancreas(1)	1				OV - Ovarian serous cystadenocarcinoma(145;1.03e-40)|Epithelial(140;3.58e-37)|GBM - Glioblastoma multiforme(294;0.00164)|READ - Rectum adenocarcinoma(205;0.196)		TCTGAAGGTTACTGATCCCCG	0.647			NA											8	33					0	0	0.004482	0	0
COL5A1	1289	broad.mit.edu	37	9	137716553	137716554	+	Missense_Mutation	DNP	GG	GG	TT			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr9:137716553_137716554GG>TT	uc004cfe.2	+	62	5188_5189	c.4806_4807GG>TT	c.(4804-4809)GTGGAC>GTTTAC	p.D1603Y	uc004cff.2_Intron	NM_000093	NP_000084	P20908	CO5A1_HUMAN	alpha 1 type V collagen preproprotein	1603	Nonhelical region.				axon guidance|cell adhesion|collagen biosynthetic process|collagen fibril organization|eye morphogenesis|fibril organization|integrin biosynthetic process|skin development|wound healing, spreading of epidermal cells	collagen type V	heparin binding|integrin binding|platelet-derived growth factor binding|proteoglycan binding			skin(4)|ovary(3)|pancreas(2)|central_nervous_system(1)|kidney(1)	11		Myeloproliferative disorder(178;0.0341)		all cancers(34;2.28e-08)|OV - Ovarian serous cystadenocarcinoma(145;6.03e-08)|Epithelial(140;6.4e-08)|GBM - Glioblastoma multiforme(294;0.131)		AGAACTACGTGGACTACGCGGA	0.624			NA											6	44					0	0	0.004672	0	0
SEC16A	9919	broad.mit.edu	37	9	139360558	139360558	+	Missense_Mutation	SNP	C	C	A			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr9:139360558C>A	uc004chx.2	-	8	4468	c.4159G>T	c.(4159-4161)GCC>TCC	p.A1387S	SEC16A_uc004chv.3_Missense_Mutation_p.A777S|SEC16A_uc004chw.2_Missense_Mutation_p.A1387S|SEC16A_uc010nbn.2_Missense_Mutation_p.A1387S	NM_014866	NP_055681	O15027	SC16A_HUMAN	SEC16 homolog A	1209	Required for endoplasmic reticulum localization.				protein transport|vesicle-mediated transport	endoplasmic reticulum membrane|Golgi membrane					0		Myeloproliferative disorder(178;0.0511)		Epithelial(140;2.9e-06)|OV - Ovarian serous cystadenocarcinoma(145;5.88e-06)		TAGGAACCGGCAGCCACATTG	0.522			NA											13	68					2.31682e-05	2.94679e-05	0.003163	1	0
MXRA5	25878	broad.mit.edu	37	X	3240552	3240552	+	Missense_Mutation	SNP	C	C	A			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chrX:3240552C>A	uc004crg.3	-	5	3331	c.3174G>T	c.(3172-3174)AAG>AAT	p.K1058N		NM_015419	NP_056234	Q9NR99	MXRA5_HUMAN	adlican precursor	1058						extracellular region				ovary(5)|lung(1)|central_nervous_system(1)|skin(1)	8		all_lung(23;0.00031)|Lung NSC(23;0.000946)				CTTTCATACCCTTTTTAATCA	0.463			NA											9	110					1.12685e-05	1.45284e-05	0.004482	1	0
HCCS	3052	broad.mit.edu	37	X	11136729	11136729	+	Silent	SNP	C	C	T			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chrX:11136729C>T	uc004cuk.2	+	5	776	c.510C>T	c.(508-510)GCC>GCT	p.A170A	HCCS_uc004cuj.2_Silent_p.A170A|HCCS_uc004cul.1_Silent_p.A170A	NM_005333	NP_005324	P53701	CCHL_HUMAN	holocytochrome c synthase	170					organ morphogenesis|oxidation-reduction process	mitochondrial inner membrane	holocytochrome-c synthase activity|metal ion binding				0						AGTGGGAAGCCCTTCATGCTG	0.348	Ovarian(86;1338 1347 1462 10340 37882)		NA											10	59					0	0	0.008291	0	0
BEND2	139105	broad.mit.edu	37	X	18234682	18234682	+	Missense_Mutation	SNP	C	C	A			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chrX:18234682C>A	uc004cyj.3	-	2	351	c.197G>T	c.(196-198)GGC>GTC	p.G66V	BEND2_uc010nfb.2_Missense_Mutation_p.G66V	NM_153346	NP_699177	Q8NDZ0	BEND2_HUMAN	BEN domain containing 2	66										ovary(3)|kidney(1)|central_nervous_system(1)	5						ATCATTGCCGCCTGGAAAATT	0.413			NA											8	72					5.18039e-06	6.7716e-06	0.00308	1	0
CXorf27	25763	broad.mit.edu	37	X	37850387	37850387	+	Missense_Mutation	SNP	G	G	A			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chrX:37850387G>A	uc004ddt.3	+	1	318	c.295G>A	c.(295-297)GAG>AAG	p.E99K		NM_012274	NP_036406	O75409	HYPM_HUMAN	Huntingtin interacting protein M	99							DNA binding			central_nervous_system(1)	1						CCACAGCGCTGAGAGTGATGT	0.527			NA											6	29					0	0	0.001168	0	0
RGN	9104	broad.mit.edu	37	X	46949284	46949284	+	Missense_Mutation	SNP	T	T	G			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chrX:46949284T>G	uc004dgz.1	+	5	1425	c.456T>G	c.(454-456)ATT>ATG	p.I152M	RGN_uc004dha.1_Missense_Mutation_p.I152M|RGN_uc010nho.1_Missense_Mutation_p.I99M|RGN_uc010nhp.1_Intron	NM_152869	NP_690608	Q15493	RGN_HUMAN	regucalcin	152					cellular calcium ion homeostasis|positive regulation of ATPase activity|regulation of calcium-mediated signaling	cytoplasm|nucleus	calcium ion binding|enzyme regulator activity|gluconolactonase activity|zinc ion binding				0						AGGTGGACATTTCCAATGGTT	0.502			NA											11	71					0	0	0.008291	0	0
PCDH11X	27328	broad.mit.edu	37	X	91873602	91873602	+	Missense_Mutation	SNP	C	C	A			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chrX:91873602C>A	uc004efk.1	+	7	4552	c.3707C>A	c.(3706-3708)CCA>CAA	p.P1236Q	PCDH11X_uc004efl.1_Missense_Mutation_p.P1226Q|PCDH11X_uc004efo.1_Missense_Mutation_p.P1199Q|PCDH11X_uc010nmv.1_3'UTR|PCDH11X_uc004efm.1_Missense_Mutation_p.P1228Q|PCDH11X_uc004efn.1_Missense_Mutation_p.P1218Q	NM_032968	NP_116750	Q9BZA7	PC11X_HUMAN	protocadherin 11 X-linked isoform c	1236	Cytoplasmic (Potential).				homophilic cell adhesion	integral to plasma membrane	calcium ion binding			large_intestine(2)	2						CACAGCCCACCATCAGCACAG	0.587	NSCLC(38;925 1092 2571 38200 45895)		NA											22	129					7.41877e-09	1.07392e-08	0.001882	1	0
PCDH19	57526	broad.mit.edu	37	X	99663320	99663320	+	Silent	SNP	C	C	G			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chrX:99663320C>G	uc010nmz.2	-	1	1952	c.276G>C	c.(274-276)CTG>CTC	p.L92L	PCDH19_uc004efw.3_Silent_p.L92L|PCDH19_uc004efx.3_Silent_p.L92L	NM_020766	NP_001098713	Q8TAB3	PCD19_HUMAN	protocadherin 19 isoform b	92	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)|breast(2)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	7						TCTGGCGGCACAGCAGATCAC	0.552			NA											17	51					0	0	0.004007	0	0
NXF5	55998	broad.mit.edu	37	X	101096645	101096645	+	Splice_Site	SNP	C	C	A			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chrX:101096645C>A	uc011mrk.1	-	5	600	c.240_splice	c.e5+1	p.K80_splice	NXF5_uc004eih.1_Splice_Site|NXF5_uc004eii.1_Splice_Site|NXF5_uc004eij.1_Splice_Site|NXF5_uc004eik.1_Intron|NXF5_uc004eil.1_Intron	NM_032946	NP_116564	Q9H1B4	NXF5_HUMAN	nuclear RNA export factor 5						mRNA export from nucleus|multicellular organismal development	actin cytoskeleton|cytoplasm|nucleus	nucleocytoplasmic transporter activity|nucleotide binding|protein binding|RNA binding			central_nervous_system(1)	1						TCAGCACACACCTTTTGGTTC	0.493			NA											25	116					2.98393e-07	4.08936e-07	0.00278	1	0
NXF3	56000	broad.mit.edu	37	X	102339665	102339665	+	Missense_Mutation	SNP	G	G	C			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chrX:102339665G>C	uc004eju.2	-	2	246	c.175C>G	c.(175-177)CAC>GAC	p.H59D	NXF3_uc010noi.1_5'Flank|NXF3_uc011mrw.1_Missense_Mutation_p.H59D|NXF3_uc011mrx.1_Intron	NM_022052	NP_071335	Q9H4D5	NXF3_HUMAN	nuclear RNA export factor 3	59						cytoplasm|nuclear RNA export factor complex	nucleocytoplasmic transporter activity|nucleotide binding|protein binding			ovary(1)|lung(1)|central_nervous_system(1)	3						GAGTCCATGTGGGCACCATGC	0.453			NA											23	133					0	0	0.002299	0	0
NRK	203447	broad.mit.edu	37	X	105168969	105168969	+	Silent	SNP	A	A	C			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chrX:105168969A>C	uc004emd.2	+	19	3561	c.3258A>C	c.(3256-3258)ACA>ACC	p.T1086T	NRK_uc010npc.1_Silent_p.T754T	NM_198465	NP_940867	Q7Z2Y5	NRK_HUMAN	Nik related kinase	1086							ATP binding|protein serine/threonine kinase activity|small GTPase regulator activity			breast(7)|ovary(3)|lung(2)|large_intestine(1)|central_nervous_system(1)	14						GCTCAGAGACAGATGGTCCAG	0.468			NA								HNSCC(51;0.14)			17	85					0	0	0.00499	0	0
SERPINA7	6906	broad.mit.edu	37	X	105280635	105280635	+	Missense_Mutation	SNP	G	G	T			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chrX:105280635G>T	uc004eme.1	-	1	431	c.415C>A	c.(415-417)CAT>AAT	p.H139N	SERPINA7_uc010npd.2_Missense_Mutation_p.H139N|SERPINA7_uc010npe.1_Missense_Mutation_p.H139N	NM_000354	NP_000345	P05543	THBG_HUMAN	serine (or cysteine) proteinase inhibitor, clade	139					regulation of proteolysis	extracellular space	serine-type endopeptidase inhibitor activity				0					Levothyroxine(DB00451)|Liothyronine(DB00279)	GGTTTCAGATGCTTGCCAATG	0.448			NA											15	209					3.41278e-10	5.08325e-10	0.00499	1	0
GUCY2F	2986	broad.mit.edu	37	X	108628439	108628439	+	Missense_Mutation	SNP	G	G	T	rs55735218		TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chrX:108628439G>T	uc004eod.3	-	16	3305	c.3029C>A	c.(3028-3030)GCT>GAT	p.A1010D	GUCY2F_uc011msq.1_RNA	NM_001522	NP_001513	P51841	GUC2F_HUMAN	guanylate cyclase 2F precursor	1010	Guanylate cyclase.|Cytoplasmic (Potential).				intracellular signal transduction|receptor guanylyl cyclase signaling pathway|visual perception	integral to plasma membrane|nuclear outer membrane	ATP binding|GTP binding|guanylate cyclase activity|protein kinase activity|receptor activity			lung(4)|breast(3)|central_nervous_system(1)	8						CATCCGAGAAGCTGTGTTCAC	0.493			NA											18	72					7.45023e-12	1.1681e-11	0.001523	1	0
CT47B1	643311	broad.mit.edu	37	X	120008751	120008751	+	Missense_Mutation	SNP	C	C	G			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chrX:120008751C>G	uc011muc.1	-	1	1029	c.774G>C	c.(772-774)GAG>GAC	p.E258D		NM_001145718	NP_001139190	P0C2W7	CT47B_HUMAN	cancer/testis antigen family 147, member B1	258											0						CCCCCTTACCCTCGGGGGCCA	0.542			NA											34	151					0	0	0.003755	0	0
UTP14A	10813	broad.mit.edu	37	X	129040189	129040189	+	Missense_Mutation	SNP	G	G	T			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chrX:129040189G>T	uc004euz.2	+	1	31	c.3G>T	c.(1-3)ATG>ATT	p.M1I	UTP14A_uc011mup.1_Missense_Mutation_p.M1I|UTP14A_uc011muq.1_5'UTR	NM_006649	NP_006640	Q9BVJ6	UT14A_HUMAN	UTP14, U3 small nucleolar ribonucleoprotein,	1					rRNA processing	nucleolus|small-subunit processome	protein binding			ovary(2)	2						CTGCTGAAATGACTGCGAACC	0.577			NA											19	125					8.34094e-07	1.12404e-06	0.008871	1	0
MCF2	4168	broad.mit.edu	37	X	138680577	138680577	+	Missense_Mutation	SNP	C	C	A			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chrX:138680577C>A	uc004fau.2	-	17	2211	c.1917G>T	c.(1915-1917)CAG>CAT	p.Q639H	MCF2_uc004fav.2_Missense_Mutation_p.Q655H|MCF2_uc011mwl.1_Missense_Mutation_p.Q616H|MCF2_uc010nsh.1_Missense_Mutation_p.Q639H|MCF2_uc011mwm.1_Missense_Mutation_p.Q600H|MCF2_uc011mwn.1_Missense_Mutation_p.Q784H|MCF2_uc004faw.2_Missense_Mutation_p.Q699H|MCF2_uc011mwo.1_Missense_Mutation_p.Q715H	NM_005369	NP_005360	P10911	MCF2_HUMAN	MCF.2 cell line derived transforming sequence	639	DH.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytoskeleton|cytosol|membrane|membrane fraction	protein binding|Rho guanyl-nucleotide exchange factor activity			lung(1)|pleura(1)	2	Acute lymphoblastic leukemia(192;0.000127)					TCAACAATAACTGATATTTAG	0.303			NA											9	44					3.09899e-07	4.23678e-07	0.004482	1	0
BAI2	576	broad.mit.edu	37	1	32203823	32203823	+	Frame_Shift_Del	DEL	A	A	-			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr1:32203823delA	uc001btn.2	-	18	3104	c.2750delT	c.(2749-2751)CTAfs	p.L917fs	BAI2_uc001btm.2_5'Flank|BAI2_uc001btp.1_5'Flank|BAI2_uc010ogn.1_5'Flank|BAI2_uc010ogo.1_Frame_Shift_Del_p.L559fs|BAI2_uc010ogp.1_Frame_Shift_Del_p.L850fs|BAI2_uc010ogq.1_Frame_Shift_Del_p.L917fs|BAI2_uc001bto.2_Frame_Shift_Del_p.L917fs|BAI2_uc001btq.1_Frame_Shift_Del_p.L850fs	NM_001703	NP_001694	O60241	BAI2_HUMAN	brain-specific angiogenesis inhibitor 2	917	Extracellular (Potential).|GPS.				negative regulation of angiogenesis|neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			lung(5)|breast(4)|ovary(2)|central_nervous_system(1)|skin(1)	13		Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0606)|all_neural(195;0.0837)|Breast(348;0.174)		STAD - Stomach adenocarcinoma(196;0.0557)		CGGCTGGGCTAGTACAGCAAA	0.617			NA											7	34	---	---	---	---	NA	NA	NA	NA	NA
OR1C1	26188	broad.mit.edu	37	1	247920769	247920769	+	Frame_Shift_Del	DEL	G	G	-			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr1:247920769delG	uc010pza.1	-	1	940	c.940delC	c.(940-942)CAAfs	p.Q314fs		NM_012353	NP_036485	Q15619	OR1C1_HUMAN	olfactory receptor, family 1, subfamily C,	314	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	all_cancers(71;4.34e-05)|all_epithelial(71;1.13e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0786)|Lung NSC(105;0.0858)	all_cancers(173;0.0247)	OV - Ovarian serous cystadenocarcinoma(106;0.0168)			GGTCATTATTGCTGCTGAAAG	0.408			NA											51	134	---	---	---	---	NA	NA	NA	NA	NA
SERPING1	710	broad.mit.edu	37	11	57367632	57367640	+	In_Frame_Del	DEL	CAGATTCTC	CAGATTCTC	-			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	CAGATTCTC	CAGATTCTC	-	-	CAGATTCTC	CAGATTCTC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr11:57367632_57367640delCAGATTCTC	uc001nkp.1	+	3	523_531	c.332_340delCAGATTCTC	c.(331-342)ACAGATTCTCCT>ACT	p.DSP112del	SERPING1_uc001nkq.1_In_Frame_Del_p.DSP112del|SERPING1_uc010rju.1_In_Frame_Del_p.DSP60del|SERPING1_uc010rjv.1_In_Frame_Del_p.DSP117del|SERPING1_uc001nkr.1_In_Frame_Del_p.DSP112del|SERPING1_uc009ymi.1_In_Frame_Del_p.DSP112del|SERPING1_uc009ymj.1_In_Frame_Del_p.DSP112del|SERPING1_uc001nks.1_Intron	NM_000062	NP_000053	P05155	IC1_HUMAN	serpin peptidase inhibitor, clade G, member 1	112_114	7 X 4 AA tandem repeats of [QE]-P-T-[TQ].		Missing (in HAE; type 2).		blood circulation|blood coagulation, intrinsic pathway|complement activation, classical pathway|innate immune response|negative regulation of complement activation, lectin pathway|platelet activation|platelet degranulation	extracellular space|platelet alpha granule lumen	protein binding|serine-type endopeptidase inhibitor activity			central_nervous_system(1)	1						cagctcccaacagattctcctacccagcc	0.225			NA							Hereditary_Angioedema				11	107	---	---	---	---	NA	NA	NA	NA	NA
TAS2R20	259295	broad.mit.edu	37	12	11149674	11149674	+	Frame_Shift_Del	DEL	A	A	-			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr12:11149674delA	uc001qzm.2	-	1	801	c.801delT	c.(799-801)TTTfs	p.F267fs	PRR4_uc009zhp.2_Intron|PRH1_uc001qzb.3_Intron|PRH1_uc001qzc.2_Intron|PRB4_uc001qzf.1_Intron|PRH1_uc001qzj.2_Intron	NM_176889	NP_795370	P59543	T2R20_HUMAN	taste receptor, type 2, member 20	267	Helical; Name=7; (Potential).				sensory perception of taste	integral to membrane	G-protein coupled receptor activity				0						ATATGATTCCAAAAGCTTGGC	0.383			NA											26	107	---	---	---	---	NA	NA	NA	NA	NA
MYH8	4626	broad.mit.edu	37	17	10322075	10322076	+	Frame_Shift_Ins	INS	-	-	A			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr17:10322075_10322076insA	uc002gmm.2	-	5	492_493	c.397_398insT	c.(397-399)TGGfs	p.W133fs	uc002gml.1_Intron	NM_002472	NP_002463	P13535	MYH8_HUMAN	myosin, heavy chain 8, skeletal muscle,	133	Myosin head-like.				muscle filament sliding	cytosol|muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			skin(6)|ovary(3)|breast(2)	11						CACCGGCAGCCACTTGTAGGGG	0.53			NA							Trismus-Pseudocamptodactyly_Syndrome_with_Cardiac_Myxoma_and_Freckling				18	145	---	---	---	---	NA	NA	NA	NA	NA
MUC16	94025	broad.mit.edu	37	19	9084723	9084723	+	Frame_Shift_Del	DEL	G	G	-			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr19:9084723delG	uc002mkp.2	-	1	7296	c.7092delC	c.(7090-7092)CCCfs	p.P2364fs		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	2364	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						TGCTATCTGAGGGGAGCTCAT	0.438			NA											17	63	---	---	---	---	NA	NA	NA	NA	NA
ZEB2	9839	broad.mit.edu	37	2	145157401	145157401	+	Frame_Shift_Del	DEL	G	G	-			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr2:145157401delG	uc002tvu.2	-	8	1833	c.1353delC	c.(1351-1353)CCCfs	p.P451fs	ZEB2_uc002tvv.2_Frame_Shift_Del_p.P445fs|ZEB2_uc010zbm.1_Frame_Shift_Del_p.P422fs|ZEB2_uc010fnp.2_Intron|ZEB2_uc010fnq.1_Frame_Shift_Del_p.P480fs	NM_014795	NP_055610	O60315	ZEB2_HUMAN	zinc finger homeobox 1b	451	SMAD-MH2 binding domain (By similarity).					cytoplasm|nucleolus	phosphatase regulator activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|SMAD binding|zinc ion binding			ovary(5)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)	9				BRCA - Breast invasive adenocarcinoma(221;0.112)		TATTCATGGTGGGAAACCCAA	0.453	Melanoma(33;1235 1264 5755 16332)		NA											14	70	---	---	---	---	NA	NA	NA	NA	NA
PLCL1	5334	broad.mit.edu	37	2	198950220	198950220	+	Frame_Shift_Del	DEL	G	G	-			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr2:198950220delG	uc010fsp.2	+	2	2270	c.1979delG	c.(1978-1980)TGGfs	p.W660fs	PLCL1_uc002uuv.3_Frame_Shift_Del_p.W581fs	NM_001114661	NP_001108133	Q15111	PLCL1_HUMAN	RecName: Full=Inactive phospholipase C-like protein 1;          Short=PLC-L1; AltName: Full=Phospholipase C-deleted in lung carcinoma; AltName: Full=Phospholipase C-related but catalytically inactive protein;          Short=PRIP;	660	PI-PLC Y-box.				intracellular signal transduction|lipid metabolic process	cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			ovary(1)|skin(1)	2					Quinacrine(DB01103)	CAGGACTTTTGGAATTGTGGC	0.413			NA											13	74	---	---	---	---	NA	NA	NA	NA	NA
GMPPA	29926	broad.mit.edu	37	2	220366738	220366738	+	Frame_Shift_Del	DEL	T	T	-			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr2:220366738delT	uc002vlr.2	+	5	476	c.408delT	c.(406-408)CCTfs	p.P136fs	GMPPA_uc002vls.2_Frame_Shift_Del_p.P136fs|GMPPA_uc002vlt.2_Frame_Shift_Del_p.P136fs|GMPPA_uc002vlu.2_Frame_Shift_Del_p.P136fs|GMPPA_uc002vlv.2_Frame_Shift_Del_p.P136fs|GMPPA_uc002vlw.2_RNA|GMPPA_uc002vlx.2_Frame_Shift_Del_p.P136fs	NM_013335	NP_037467	Q96IJ6	GMPPA_HUMAN	GDP-mannose pyrophosphorylase A	136					dolichol-linked oligosaccharide biosynthetic process|GDP-mannose biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine		GTP binding|mannose-1-phosphate guanylyltransferase activity				0		Renal(207;0.0183)		Epithelial(149;3.82e-10)|all cancers(144;6.25e-08)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00807)|READ - Rectum adenocarcinoma(5;0.148)		AGCGTCACCCTTTCTTACTCC	0.597			NA											18	169	---	---	---	---	NA	NA	NA	NA	NA
ERG	2078	broad.mit.edu	37	21	39772482	39772497	+	Splice_Site	DEL	GGGTGTTTTCGTACCT	GGGTGTTTTCGTACCT	-	rs67010649		TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	GGGTGTTTTCGTACCT	GGGTGTTTTCGTACCT	-	-	GGGTGTTTTCGTACCT	GGGTGTTTTCGTACCT	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr21:39772482_39772497delGGGTGTTTTCGTACCT	uc010gnw.2	-	8	1061	c.766_splice	c.e8+1	p.D256_splice	ERG_uc002yxa.2_Splice_Site_p.D249_splice|ERG_uc011aek.1_Splice_Site_p.D157_splice|ERG_uc010gnv.2_Intron|ERG_uc010gnx.2_Intron|ERG_uc011ael.1_Splice_Site_p.D256_splice|ERG_uc002yxb.2_Intron|ERG_uc011aem.1_Intron|ERG_uc002yxc.3_Frame_Shift_Del_p.P255fs|ERG_uc010gny.1_Intron	NM_001136155	NP_001129627	P11308	ERG_HUMAN	ets-related isoform 4						cell proliferation|multicellular organismal development|protein phosphorylation	cytoplasm|nucleus|ribonucleoprotein complex	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|signal transducer activity		TMPRSS2/ERG(2499)|FUS/ERG(163)|EWSR1/ERG(162)	prostate(2499)|bone(167)|haematopoietic_and_lymphoid_tissue(153)|soft_tissue(5)|lung(2)|skin(1)|ovary(1)	2828		Prostate(19;3.6e-06)				GATCACACAGGGGTGTTTTCGTACCTGGCCTAGTTG	0.468	Esophageal Squamous(130;336 1700 3010 3083 40589)		NA											8	158	---	---	---	---	NA	NA	NA	NA	NA
MX2	4600	broad.mit.edu	37	21	42752078	42752078	+	Frame_Shift_Del	DEL	G	G	-			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr21:42752078delG	uc002yzf.1	+	4	681	c.577delG	c.(577-579)GCCfs	p.A193fs	MX2_uc011aer.1_Intron	NM_002463	NP_002454	P20592	MX2_HUMAN	myxovirus resistance protein 2	193					response to virus|type I interferon-mediated signaling pathway	cytoplasm|nucleus	GTP binding|GTPase activity			ovary(2)	2		Prostate(19;1.57e-07)|all_epithelial(19;0.0222)				GATACACAAAGGTGGGCCCAC	0.577			NA											8	65	---	---	---	---	NA	NA	NA	NA	NA
CLOCK	9575	broad.mit.edu	37	4	56336954	56336954	+	Frame_Shift_Del	DEL	A	A	-			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr4:56336954delA	uc003haz.1	-	9	1294	c.368delT	c.(367-369)TTAfs	p.L123fs	CLOCK_uc003hba.1_Frame_Shift_Del_p.L123fs	NM_004898	NP_004889	O15516	CLOCK_HUMAN	clock	123	PAS 1.				circadian rhythm|photoperiodism|positive regulation of transcription from RNA polymerase II promoter	cytoplasm|transcription factor complex	DNA binding|histone acetyltransferase activity|sequence-specific DNA binding transcription factor activity|signal transducer activity			central_nervous_system(2)|ovary(1)	3	Lung NSC(11;0.00335)|Glioma(25;0.08)|all_epithelial(27;0.0992)|all_neural(26;0.101)		LUSC - Lung squamous cell carcinoma(4;1.62e-07)|Lung(4;1.34e-06)|Epithelial(7;0.0107)			CATGATTGCTAAAAAAAAACC	0.289			NA											7	131	---	---	---	---	NA	NA	NA	NA	NA
ADAMTS12	81792	broad.mit.edu	37	5	33649781	33649781	+	Frame_Shift_Del	DEL	C	C	-			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr5:33649781delC	uc003jia.1	-	8	1375	c.1212delG	c.(1210-1212)GGGfs	p.G404fs	ADAMTS12_uc010iuq.1_Frame_Shift_Del_p.G404fs	NM_030955	NP_112217	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1	404	Peptidase M12B.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|kidney(1)	9						CATTTTCTTTCCCATCATGCT	0.532			NA								HNSCC(64;0.19)			8	90	---	---	---	---	NA	NA	NA	NA	NA
FBXO38	81545	broad.mit.edu	37	5	147793698	147793698	+	Splice_Site	DEL	G	G	-			TCGA-49-4487-01A-21D-1855-08	TCGA-49-4487-11A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	9bd8e303-a81e-4ff8-882b-d46a2f7c55d2	e723bda4-998c-4669-82a2-d392eb6b54be	g.chr5:147793698delG	uc003lpf.1	+	10	1214	c.1094_splice	c.e10-1	p.S365_splice	FBXO38_uc003lpg.1_Splice_Site_p.S365_splice|FBXO38_uc003lph.2_Splice_Site_p.S365_splice	NM_205836	NP_995308	Q6PIJ6	FBX38_HUMAN	F-box protein 38 isoform b							cytoplasm|nucleus				ovary(4)|skin(2)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCTCTTTTTAGGCAGAATGGC	0.358			NA											12	94	---	---	---	---	NA	NA	NA	NA	NA