Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	ACHILLES_Top_Genes	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
SLC2A5	6518	broad.mit.edu	37	1	9097678	9097678	+	Silent	SNP	C	C	G			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr1:9097678C>G	uc001apo.2	-	12	1765	c.1473G>C	c.(1471-1473)CTG>CTC	p.L491L	SLC2A5_uc010nzy.1_Silent_p.L432L|SLC2A5_uc010nzz.1_Silent_p.L376L|SLC2A5_uc010oaa.1_Silent_p.L447L|SLC2A5_uc010oab.1_Silent_p.L491L	NM_003039	NP_003030	P22732	GTR5_HUMAN	solute carrier family 2 (facilitated	491	Cytoplasmic (Potential).				carbohydrate metabolic process	integral to membrane|plasma membrane	fructose transmembrane transporter activity|glucose transmembrane transporter activity			pancreas(2)|ovary(1)	3	Ovarian(185;0.112)|all_lung(157;0.185)	all_epithelial(116;1.34e-15)|all_lung(118;9.46e-05)|Lung NSC(185;0.000172)|Renal(390;0.000469)|Colorectal(325;0.0062)|Breast(348;0.00715)|Hepatocellular(190;0.0228)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.104)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;7.78e-07)|COAD - Colon adenocarcinoma(227;8.83e-05)|Kidney(185;0.000286)|KIRC - Kidney renal clear cell carcinoma(229;0.00103)|STAD - Stomach adenocarcinoma(132;0.0019)|BRCA - Breast invasive adenocarcinoma(304;0.00199)|READ - Rectum adenocarcinoma(331;0.0649)		GAAGCTCTTTCAGTTCCTCCT	0.493			NA											4	233					0	0	0.000602	0	0
MTOR	2475	broad.mit.edu	37	1	11297992	11297992	+	Missense_Mutation	SNP	C	C	G			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr1:11297992C>G	uc001asd.2	-	13	2237	c.2116G>C	c.(2116-2118)GAG>CAG	p.E706Q		NM_004958	NP_004949	P42345	MTOR_HUMAN	FK506 binding protein 12-rapamycin associated	706					cell growth|cellular response to hypoxia|insulin receptor signaling pathway|nerve growth factor receptor signaling pathway|peptidyl-serine phosphorylation|phosphatidylinositol-mediated signaling|protein autophosphorylation|protein catabolic process|response to amino acid stimulus|response to nutrient|T cell costimulation|TOR signaling cascade	endoplasmic reticulum membrane|Golgi membrane|lysosome|mitochondrial outer membrane|phosphatidylinositol 3-kinase complex|PML body|TORC1 complex|TORC2 complex	ATP binding|phosphoprotein binding|protein serine/threonine kinase activity			central_nervous_system(7)|lung(6)|ovary(6)|skin(3)|kidney(3)|large_intestine(2)|breast(2)	29						TCCCGGATCTCAAACACCTGG	0.572			NA											7	80					0	0	0.004482	0	0
CASP9	842	broad.mit.edu	37	1	15819510	15819510	+	Silent	SNP	C	C	T			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr1:15819510C>T	uc001awn.2	-	9	1274	c.1179G>A	c.(1177-1179)GTG>GTA	p.V393V	CASP9_uc001awm.1_3'UTR|CASP9_uc001awo.2_Silent_p.V243V|CASP9_uc001awp.2_Silent_p.V237V|CASP9_uc009voi.2_Silent_p.V237V|CASP9_uc010obm.1_Silent_p.V310V|CASP9_uc001awq.2_Silent_p.V310V	NM_001229	NP_001220	P55211	CASP9_HUMAN	caspase 9 isoform alpha preproprotein	393					activation of caspase activity by cytochrome c|induction of apoptosis by intracellular signals|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling	cytosol	cysteine-type endopeptidase activity|enzyme activator activity|protein binding			central_nervous_system(1)|kidney(1)	2		Breast(348;0.000207)|all_lung(284;0.000211)|Colorectal(325;0.000259)|Lung NSC(340;0.000269)|Renal(390;0.000518)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;8.49e-07)|COAD - Colon adenocarcinoma(227;4.36e-05)|BRCA - Breast invasive adenocarcinoma(304;0.00013)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(313;0.00763)|READ - Rectum adenocarcinoma(331;0.0655)		AAATCCCTTTCACCGAAACAG	0.458			NA											65	130					0	0	0.01441	0	0
SEPN1	57190	broad.mit.edu	37	1	26139275	26139275	+	Missense_Mutation	SNP	C	C	T			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr1:26139275C>T	uc010oer.1	+	12	1434	c.1379C>T	c.(1378-1380)TCC>TTC	p.S460F	SEPN1_uc010oes.1_Missense_Mutation_p.S426F	NM_020451	NP_065184	Q9NZV5	SELN_HUMAN	selenoprotein N, 1 isoform 1 precursor	460						endoplasmic reticulum membrane|extracellular region	protein binding			ovary(2)	2		Colorectal(325;3.46e-05)|Lung NSC(340;0.00038)|all_lung(284;0.00051)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0155)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0505)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0421)|OV - Ovarian serous cystadenocarcinoma(117;1.26e-25)|Colorectal(126;3.01e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.000751)|BRCA - Breast invasive adenocarcinoma(304;0.00099)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.0143)|READ - Rectum adenocarcinoma(331;0.0649)		GATGACCAGTCCTGCTGAGGT	0.597			NA											11	20					0	0	0.00245	0	0
TMEM39B	55116	broad.mit.edu	37	1	32568034	32568034	+	Silent	SNP	C	C	T			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr1:32568034C>T	uc010ogv.1	+	9	1385	c.1239C>T	c.(1237-1239)TTC>TTT	p.F413F	TMEM39B_uc001bue.3_Silent_p.F414F|TMEM39B_uc001buf.3_Silent_p.F214F|TMEM39B_uc010ogw.1_Silent_p.F214F	NM_018056	NP_060526	Q9GZU3	TM39B_HUMAN	transmembrane protein 39B	413						integral to membrane					0		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Ovarian(437;0.101)|Breast(348;0.174)				CCGGGCAGTTCTTTTTCAGCA	0.567			NA											10	108					0	0	0.010729	0	0
TSPAN1	10103	broad.mit.edu	37	1	46649908	46649908	+	Missense_Mutation	SNP	G	G	A			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr1:46649908G>A	uc001cpd.2	+	4	567	c.103G>A	c.(103-105)GAT>AAT	p.D35N	TSPAN1_uc009vyd.1_Missense_Mutation_p.D35N	NM_005727	NP_005718	O60635	TSN1_HUMAN	tetraspan 1	35	Extracellular (Potential).					integral to membrane|lysosomal membrane				ovary(1)	1	Acute lymphoblastic leukemia(166;0.155)	Medulloblastoma(700;0.00498)|all_neural(321;0.0212)				GGTGTCAATCGATGGGGCATC	0.567			NA											17	159					0	0	0.00278	0	0
NSUN4	387338	broad.mit.edu	37	1	46827467	46827467	+	Silent	SNP	C	C	G			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr1:46827467C>G	uc001cpr.1	+	6	1213	c.1104C>G	c.(1102-1104)CTC>CTG	p.L368L	NSUN4_uc010omc.1_Silent_p.L319L|NSUN4_uc009vyf.1_Silent_p.L217L|NSUN4_uc009vyg.1_Silent_p.L319L|NSUN4_uc001cpt.1_RNA|NSUN4_uc001cps.1_RNA	NM_199044	NP_950245	Q96CB9	NSUN4_HUMAN	NOL1/NOP2/Sun domain family 4 protein	368							methyltransferase activity				0	Acute lymphoblastic leukemia(166;0.155)					TACCAAACCTCATGGCCAATT	0.453			NA											19	80					0	0	0.007413	0	0
LRRC42	115353	broad.mit.edu	37	1	54418039	54418039	+	Missense_Mutation	SNP	G	G	A			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr1:54418039G>A	uc001cwj.1	+	2	567	c.367G>A	c.(367-369)GAA>AAA	p.E123K	LRRC42_uc001cwl.1_Missense_Mutation_p.E123K|LRRC42_uc001cwk.1_Missense_Mutation_p.E123K|LRRC42_uc009vzm.1_Missense_Mutation_p.E123K	NM_052940	NP_443172	Q9Y546	LRC42_HUMAN	leucine rich repeat containing 42	123											0						CTCTGCTGCTGAAGCCAGACA	0.493			NA											4	112					0	0	0.009096	0	0
ANKRD34A	284615	broad.mit.edu	37	1	145473380	145473380	+	Missense_Mutation	SNP	C	C	A			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr1:145473380C>A	uc001enq.1	+	4	1345	c.52C>A	c.(52-54)CTA>ATA	p.L18I	NBPF10_uc001emp.3_Intron|POLR3GL_uc001enp.1_5'Flank	NM_001039888	NP_001034977	Q69YU3	AN34A_HUMAN	ankyrin repeat domain 34	18	ANK 1.										0	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					TCAGGGTAAGCTACGCTTGGC	0.657			NA											37	35					1.15183e-24	1.41872e-24	0.009718	1	0
CHD1L	9557	broad.mit.edu	37	1	146727479	146727479	+	Missense_Mutation	SNP	G	G	T			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr1:146727479G>T	uc001epm.3	+	4	422	c.359G>T	c.(358-360)GGT>GTT	p.G120V	CHD1L_uc001epn.3_Missense_Mutation_p.G7V|CHD1L_uc010ozo.1_RNA|CHD1L_uc009wjg.2_RNA|CHD1L_uc009wjh.2_Missense_Mutation_p.G120V|CHD1L_uc010ozp.1_Intron|CHD1L_uc001epo.3_Intron	NM_004284	NP_004275	Q86WJ1	CHD1L_HUMAN	chromodomain helicase DNA binding protein	120	Helicase ATP-binding.				chromatin remodeling|DNA repair	cytoplasm|nucleus|plasma membrane	ATP binding|ATP-dependent DNA helicase activity|DNA binding|protein binding			ovary(3)|lung(2)|upper_aerodigestive_tract(1)	6	all_hematologic(923;0.0487)					TTTGCTCCAGGTCTTTCCTGT	0.418			NA											4	60					0.000602214	0.000683412	0.000602	1	0
CDC42SE1	56882	broad.mit.edu	37	1	151026774	151026774	+	Missense_Mutation	SNP	C	C	T			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr1:151026774C>T	uc001ewo.2	-	5	759	c.189G>A	c.(187-189)ATG>ATA	p.M63I	CDC42SE1_uc001ewp.2_Missense_Mutation_p.M63I	NM_001038707	NP_001033796	Q9NRR8	C42S1_HUMAN	CDC42 small effector 1	63					phagocytosis|regulation of cell shape|signal transduction	cytoplasm|cytoskeleton|plasma membrane	GTPase inhibitor activity				0	Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.211)			CCTTGGATCTCATCTGCTCCT	0.448			NA											12	498					0	0	0.013537	0	0
RFX5	5993	broad.mit.edu	37	1	151316755	151316755	+	Splice_Site	SNP	C	C	G			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr1:151316755C>G	uc001exv.1	-	8	688	c.474_splice	c.e8-1	p.K158_splice	RFX5_uc001exw.1_Splice_Site_p.K158_splice|RFX5_uc009wmr.1_Splice_Site_p.K158_splice|RFX5_uc010pcx.1_Splice_Site_p.K118_splice	NM_001025603	NP_001020774	P48382	RFX5_HUMAN	regulatory factor X, 5							nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1	Lung SC(34;0.00471)|Ovarian(49;0.0147)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)			GTAGCAATATCTGATGCAAGT	0.498			NA											3	119					0	0	0.004672	0	0
DENND4B	9909	broad.mit.edu	37	1	153911514	153911514	+	Silent	SNP	G	G	C			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr1:153911514G>C	uc001fdd.1	-	13	2228	c.1827C>G	c.(1825-1827)CTC>CTG	p.L609L		NM_014856	NP_055671	O75064	DEN4B_HUMAN	DENN/MADD domain containing 4B	609	dDENN.									ovary(1)	1	all_lung(78;2.89e-32)|Lung NSC(65;2.27e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)			CCCGGGATTTGAGGAAGCCTG	0.547			NA											3	39					0	0	0.004672	0	0
CHRNB2	1141	broad.mit.edu	37	1	154548343	154548343	+	Missense_Mutation	SNP	C	C	G			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr1:154548343C>G	uc001ffg.2	+	6	1708	c.1444C>G	c.(1444-1446)CTC>GTC	p.L482V		NM_000748	NP_000739	P17787	ACHB2_HUMAN	neuronal nicotinic acetylcholine receptor beta 2	482					B cell activation|behavioral response to nicotine|calcium ion transport|central nervous system projection neuron axonogenesis|lateral geniculate nucleus development|locomotory behavior|membrane depolarization|memory|negative regulation of action potential|optic nerve morphogenesis|positive regulation of B cell proliferation|positive regulation of dopamine secretion|regulation of circadian sleep/wake cycle, REM sleep|regulation of dendrite morphogenesis|regulation of dopamine metabolic process|regulation of synaptogenesis|response to cocaine|response to ethanol|response to hypoxia|sensory perception of pain|sensory perception of sound|smooth muscle contraction|social behavior|synaptic transmission involved in micturition|synaptic transmission, cholinergic|vestibulocochlear nerve development|visual learning|visual perception	cell junction|external side of plasma membrane|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity				0	all_lung(78;2.22e-29)|Lung NSC(65;3.66e-27)|Hepatocellular(266;0.0877)|all_hematologic(923;0.088)		LUSC - Lung squamous cell carcinoma(543;0.185)		Nicotine(DB00184)	CCTGCAGCCTCTCTTCCAGAA	0.562			NA											4	204					0	0	0.001168	0	0
ZBTB7B	51043	broad.mit.edu	37	1	154987712	154987712	+	Silent	SNP	G	G	T			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr1:154987712G>T	uc001fgk.3	+	3	734	c.576G>T	c.(574-576)CCG>CCT	p.P192P	ZBTB7B_uc009wpa.2_Silent_p.P192P|ZBTB7B_uc001fgj.3_Silent_p.P226P|ZBTB7B_uc010peq.1_Silent_p.P226P|ZBTB7B_uc001fgl.3_Silent_p.P192P	NM_015872	NP_056956	O15156	ZBT7B_HUMAN	zinc finger and BTB domain containing 7B	192	Pro-rich.				cell differentiation|ectoderm development|multicellular organismal development|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleus	DNA binding|zinc ion binding				0	all_epithelial(22;2.77e-30)|all_lung(78;4.1e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		BRCA - Breast invasive adenocarcinoma(34;0.00034)			CTCCGCCACCGCCACCTCGGC	0.657			NA											19	60					4.54149e-19	5.50979e-19	0.014323	1	0
TTC24	164118	broad.mit.edu	37	1	156555560	156555560	+	Silent	SNP	C	C	T			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr1:156555560C>T	uc009wsc.1	+	7	812	c.672C>T	c.(670-672)CCC>CCT	p.P224P		NM_001105669	NP_001099139	A2A3L6	TTC24_HUMAN	tetratricopeptide repeat domain 24	504							binding			pancreas(1)	1	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					CTAGTTGCCCCACGTTTACCA	0.527			NA											5	208					0	0	0.000602	0	0
FCRL4	83417	broad.mit.edu	37	1	157557312	157557312	+	Nonsense_Mutation	SNP	G	G	A			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr1:157557312G>A	uc001fqw.2	-	5	737	c.601C>T	c.(601-603)CAG>TAG	p.Q201*	FCRL4_uc010phy.1_RNA	NM_031282	NP_112572	Q96PJ5	FCRL4_HUMAN	Fc receptor-like 4 precursor	201	Ig-like C2-type 3.|Extracellular (Potential).					integral to membrane|plasma membrane	receptor activity			ovary(2)|kidney(1)|skin(1)	4	all_hematologic(112;0.0378)|Hepatocellular(266;0.178)	Prostate(1639;0.245)				TCTGTAGGCTGAGAGTCTGTA	0.478			NA											8	252					0	0	0.00308	0	0
FCRL1	115350	broad.mit.edu	37	1	157765949	157765949	+	Missense_Mutation	SNP	G	G	T			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr1:157765949G>T	uc001frg.2	-	11	1343	c.1230C>A	c.(1228-1230)GAC>GAA	p.D410E	FCRL1_uc001frf.2_RNA|FCRL1_uc001frh.2_Missense_Mutation_p.D409E|FCRL1_uc001fri.2_3'UTR|FCRL1_uc001frj.2_RNA	NM_052938	NP_443170	Q96LA6	FCRL1_HUMAN	Fc receptor-like 1 isoform 1 precursor	410	ITIM motif 4.|Cytoplasmic (Potential).					integral to membrane|plasma membrane	receptor activity			skin(4)|ovary(3)	7	all_hematologic(112;0.0378)		LUSC - Lung squamous cell carcinoma(543;0.24)			TGGAATAGATGTCTAAGGAAA	0.448	GBM(54;482 1003 11223 30131 35730)		NA											31	76					8.88839e-20	1.08487e-19	0.010818	1	0
OR6Y1	391112	broad.mit.edu	37	1	158517081	158517081	+	Missense_Mutation	SNP	G	G	T			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr1:158517081G>T	uc010pil.1	-	1	815	c.815C>A	c.(814-816)GCC>GAC	p.A272D		NM_001005189	NP_001005189	Q8NGX8	OR6Y1_HUMAN	olfactory receptor, family 6, subfamily Y,	272	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	all_hematologic(112;0.0378)					GGAATTGTAGGCATACATGAG	0.473			NA											133	135					1.02165e-56	1.28582e-56	0.01441	1	0
PPOX	5498	broad.mit.edu	37	1	161137915	161137915	+	Missense_Mutation	SNP	G	G	C			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr1:161137915G>C	uc001fyj.2	+	5	759	c.469G>C	c.(469-471)GAG>CAG	p.E157Q	PPOX_uc001fyn.2_Intron|PPOX_uc001fyg.2_Missense_Mutation_p.E157Q|PPOX_uc001fyl.2_Missense_Mutation_p.E123Q|PPOX_uc001fym.2_RNA|PPOX_uc001fyk.2_5'UTR|PPOX_uc001fyh.2_5'UTR|PPOX_uc010pkg.1_Intron|PPOX_uc009wuc.1_5'UTR|PPOX_uc010pkh.1_Intron|PPOX_uc001fyi.2_Intron	NM_001122764	NP_001116236	P50336	PPOX_HUMAN	protoporphyrinogen oxidase	157					heme biosynthetic process	intrinsic to mitochondrial inner membrane|mitochondrial intermembrane space	flavin adenine dinucleotide binding|oxygen-dependent protoporphyrinogen oxidase activity			ovary(1)	1	all_cancers(52;3.73e-19)|Breast(13;0.000577)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00275)			CCTTGGACCTGAGGTGACACT	0.572			NA							Porphyria_Variegata				4	92					0	0	0.009096	0	0
ATF6	22926	broad.mit.edu	37	1	161736217	161736217	+	Missense_Mutation	SNP	C	C	G	rs149825732		TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr1:161736217C>G	uc001gbr.2	+	1	134	c.67C>G	c.(67-69)CTG>GTG	p.L23V	ATF6_uc001gbq.1_Missense_Mutation_p.L23V	NM_007348	NP_031374	P18850	ATF6A_HUMAN	activating transcription factor 6	23	Cytoplasmic (Potential).|Transcription activation.				positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response|protein folding	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|nuclear envelope|nucleoplasm	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			ovary(2)|skin(1)	3	all_hematologic(112;0.156)		BRCA - Breast invasive adenocarcinoma(70;0.00953)			CTTTCACAGGCTGGATGAAGA	0.567			NA											12	111					0	0	0.010729	0	0
CENPL	91687	broad.mit.edu	37	1	173780416	173780416	+	Missense_Mutation	SNP	C	C	G			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr1:173780416C>G	uc001gje.3	-	2	236	c.22G>C	c.(22-24)GAG>CAG	p.E8Q	CENPL_uc009wwg.2_5'UTR|CENPL_uc001gjg.3_Missense_Mutation_p.E8Q|CENPL_uc001gjf.3_Missense_Mutation_p.E8Q	NM_033319	NP_201576	Q8N0S6	CENPL_HUMAN	centromere protein L isoform 2	8					mitotic prometaphase	chromosome, centromeric region|cytosol|nucleus					0						GGAGTTGACTCTGGTGCACTG	0.398			NA											4	193					0	0	0.009096	0	0
PRG4	10216	broad.mit.edu	37	1	186276981	186276981	+	Silent	SNP	A	A	G			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr1:186276981A>G	uc001gru.3	+	7	2181	c.2130A>G	c.(2128-2130)AAA>AAG	p.K710K	PRG4_uc001grt.3_Silent_p.K669K|PRG4_uc009wyl.2_Silent_p.K617K|PRG4_uc009wym.2_Silent_p.K576K|PRG4_uc010poo.1_Intron	NM_005807	NP_005798	Q92954	PRG4_HUMAN	proteoglycan 4 isoform A	710	59 X 8 AA repeats of K-X-P-X-P-T-T-X.|43; approximate.				cell proliferation|immune response	extracellular region	polysaccharide binding|protein binding|scavenger receptor activity			skin(1)	1						CTACCCCTAAAGGGACTGCTC	0.582			NA											5	293					0	0	0.001168	0	0
CENPF	1063	broad.mit.edu	37	1	214802433	214802433	+	Missense_Mutation	SNP	G	G	C			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr1:214802433G>C	uc001hkm.2	+	8	1287	c.1113G>C	c.(1111-1113)TTG>TTC	p.L371F		NM_016343	NP_057427	P49454	CENPF_HUMAN	centromere protein F	371	Interaction with SNAP25 and required for localization to the cytoplasm (By similarity).|Potential.				cell differentiation|cell division|cell proliferation|DNA replication|G2 phase of mitotic cell cycle|kinetochore assembly|metaphase plate congression|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|muscle organ development|negative regulation of transcription, DNA-dependent|protein transport|regulation of G2/M transition of mitotic cell cycle|regulation of striated muscle tissue development|response to drug	condensed chromosome outer kinetochore|cytosol|midbody|nuclear envelope|nuclear matrix|perinuclear region of cytoplasm|spindle pole	chromatin binding|dynein binding|protein C-terminus binding|protein homodimerization activity|transcription factor binding			ovary(6)|central_nervous_system(4)|large_intestine(2)|skin(1)	13				all cancers(67;0.00836)|OV - Ovarian serous cystadenocarcinoma(81;0.00855)|GBM - Glioblastoma multiforme(131;0.0694)|Epithelial(68;0.0833)		CGGAAGATTTGAGTTGTCAGC	0.308	Colon(80;575 1284 11000 14801 43496)		NA											3	121					0	0	0.004672	0	0
KCNK2	3776	broad.mit.edu	37	1	215259970	215259970	+	Missense_Mutation	SNP	C	C	G			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr1:215259970C>G	uc001hkq.2	+	2	475	c.306C>G	c.(304-306)TTC>TTG	p.F102L	KCNK2_uc001hko.2_Missense_Mutation_p.F98L|KCNK2_uc009xdm.2_RNA|KCNK2_uc001hkp.2_RNA|KCNK2_uc010pua.1_RNA|KCNK2_uc001hkr.3_Missense_Mutation_p.F87L	NM_001017425	NP_001017425	O95069	KCNK2_HUMAN	potassium channel, subfamily K, member 2 isoform	102							outward rectifier potassium channel activity				0				OV - Ovarian serous cystadenocarcinoma(81;0.0399)|all cancers(67;0.0556)|GBM - Glioblastoma multiforme(131;0.068)	Dofetilide(DB00204)	AGCAAACATTCATATCCCAAC	0.463			NA											15	262					0	0	0.003163	0	0
USH2A	7399	broad.mit.edu	37	1	215848324	215848324	+	Missense_Mutation	SNP	C	C	A			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr1:215848324C>A	uc001hku.1	-	63	13316	c.12929G>T	c.(12928-12930)AGC>ATC	p.S4310I		NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	4310	Fibronectin type-III 28.|Extracellular (Potential).				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		AGGATCAAAGCTAAAAGGATA	0.433			NA								HNSCC(13;0.011)			95	86					6.1132e-60	7.71791e-60	0.01441	1	0
USH2A	7399	broad.mit.edu	37	1	215914740	215914740	+	Missense_Mutation	SNP	G	G	C			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr1:215914740G>C	uc001hku.1	-	60	12075	c.11688C>G	c.(11686-11688)ATC>ATG	p.I3896M		NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	3896	Fibronectin type-III 24.|Extracellular (Potential).				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		AGTTGATGATGATTCCATTTG	0.388			NA								HNSCC(13;0.011)			34	176					0	0	0.003271	0	0
RAB3GAP2	25782	broad.mit.edu	37	1	220386243	220386243	+	Missense_Mutation	SNP	T	T	A			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr1:220386243T>A	uc010puk.1	-	4	536	c.372A>T	c.(370-372)TTA>TTT	p.L124F	RAB3GAP2_uc001hmf.2_RNA|RAB3GAP2_uc001hmg.2_5'UTR|RAB3GAP2_uc010pum.1_Missense_Mutation_p.L124F	NM_012414	NP_036546	Q9H2M9	RBGPR_HUMAN	rab3 GTPase-activating protein, non-catalytic	124					intracellular protein transport	cytoplasm|soluble fraction	GTPase activator activity|protein heterodimerization activity			central_nervous_system(1)	1				GBM - Glioblastoma multiforme(131;0.0443)		CTTCGACATTTAAGGAACCAC	0.303			NA											45	41					0	0	0.01441	0	0
PGBD5	79605	broad.mit.edu	37	1	230486821	230486821	+	Silent	SNP	C	C	G			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr1:230486821C>G	uc010pwb.1	-	3	570	c.570G>C	c.(568-570)CTG>CTC	p.L190L	PGBD5_uc001htv.2_Silent_p.L289L	NM_024554	NP_078830	Q8N414	PGBD5_HUMAN	piggyBac transposable element derived 5	190						integral to membrane				ovary(2)|central_nervous_system(1)|skin(1)	4	Breast(184;0.0397)	Prostate(94;0.167)		GBM - Glioblastoma multiforme(131;0.201)		CCTCATCGATCAGGGGTTCAT	0.388			NA											7	78					0	0	0.004482	0	0
NID1	4811	broad.mit.edu	37	1	236144994	236144994	+	Silent	SNP	C	C	T	rs148662892	byFrequency	TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr1:236144994C>T	uc001hxo.2	-	16	3246	c.3144G>A	c.(3142-3144)GCG>GCA	p.A1048A	NID1_uc009xgd.2_Silent_p.A915A|NID1_uc009xgc.2_Silent_p.A129A	NM_002508	NP_002499	P14543	NID1_HUMAN	nidogen 1 precursor	1048	LDL-receptor class B 2.				cell-matrix adhesion	basement membrane	calcium ion binding			large_intestine(1)|pancreas(1)	2	Ovarian(103;0.0544)|Breast(184;0.23)	all_cancers(173;0.00491)|Prostate(94;0.184)|Acute lymphoblastic leukemia(190;0.229)	OV - Ovarian serous cystadenocarcinoma(106;0.00162)		Becaplermin(DB00102)|Urokinase(DB00013)	CGTCCAGCTTCGCCACTTCTA	0.498			NA											5	151					0	0	0.001168	0	0
MTR	4548	broad.mit.edu	37	1	237049656	237049656	+	Missense_Mutation	SNP	A	A	C			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr1:237049656A>C	uc001hyi.3	+	27	3263	c.2840A>C	c.(2839-2841)GAA>GCA	p.E947A	MTR_uc010pxw.1_Missense_Mutation_p.E540A|MTR_uc010pxx.1_Missense_Mutation_p.E896A|MTR_uc010pxy.1_Missense_Mutation_p.E801A	NM_000254	NP_000245	Q99707	METH_HUMAN	5-methyltetrahydrofolate-homocysteine	947	AdoMet activation.				nervous system development|xenobiotic metabolic process	cytosol	cobalamin binding|homocysteine S-methyltransferase activity|methionine synthase activity|protein binding|zinc ion binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3	Ovarian(103;0.0634)|Breast(184;0.221)	all_cancers(173;2.79e-22)|all_epithelial(177;4.84e-14)|Breast(1374;0.00123)|Prostate(94;0.0181)|Lung SC(1967;0.0262)|Acute lymphoblastic leukemia(190;0.117)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)	KIRC - Kidney renal clear cell carcinoma(1967;0.248)	Hydroxocobalamin(DB00200)|L-Methionine(DB00134)|Tetrahydrofolic acid(DB00116)	TGGCTGTCTGAACCTCACCCA	0.413			NA											20	77					0	0	0.012319	0	0
SDCCAG8	10806	broad.mit.edu	37	1	243493899	243493899	+	Missense_Mutation	SNP	G	G	C			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr1:243493899G>C	uc001hzw.2	+	10	1282	c.1126G>C	c.(1126-1128)GAA>CAA	p.E376Q	SDCCAG8_uc010pyk.1_Missense_Mutation_p.E231Q|SDCCAG8_uc010pyl.1_Missense_Mutation_p.E188Q|SDCCAG8_uc001hzx.2_Missense_Mutation_p.E188Q	NM_006642	NP_006633	Q86SQ7	SDCG8_HUMAN	serologically defined colon cancer antigen 8	376	Potential.|Sufficient for homodimerization (By similarity).				establishment of cell polarity|G2/M transition of mitotic cell cycle|tube formation	cell-cell junction|centriole|cytosol	protein binding				0	all_cancers(71;0.000545)|all_epithelial(71;0.000509)|all_lung(81;0.0821)|Ovarian(71;0.0919)|all_neural(11;0.101)|Breast(184;0.218)	all_cancers(173;0.00395)	all cancers(7;1.58e-07)|GBM - Glioblastoma multiforme(7;5.12e-06)|OV - Ovarian serous cystadenocarcinoma(106;0.00392)	COAD - Colon adenocarcinoma(196;0.145)		GGAGCGACTTGAAAAAGAACT	0.443			NA											3	79					0	0	0.004672	0	0
OR2M7	391196	broad.mit.edu	37	1	248487240	248487240	+	Missense_Mutation	SNP	C	C	G	rs146462189	byFrequency	TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr1:248487240C>G	uc010pzk.1	-	1	631	c.631G>C	c.(631-633)GTT>CTT	p.V211L		NM_001004691	NP_001004691	Q8NG81	OR2M7_HUMAN	olfactory receptor, family 2, subfamily M,	211	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			ATGATTGCAACAGGGAAAACA	0.423			NA											274	294					0	0	0.01441	0	0
CSGALNACT2	55454	broad.mit.edu	37	10	43678736	43678736	+	Missense_Mutation	SNP	G	G	C			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr10:43678736G>C	uc001jan.2	+	8	1710	c.1375G>C	c.(1375-1377)GAT>CAT	p.D459H		NM_018590	NP_061060	Q8N6G5	CGAT2_HUMAN	chondroitin sulfate	459	Lumenal (Potential).				chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process|dermatan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process	Golgi cisterna membrane|integral to Golgi membrane	glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity|metal ion binding			ovary(1)	1						GGGTGGAGAAGATGTTCATCT	0.423			NA											7	300					0	0	0.00308	0	0
JMJD1C	221037	broad.mit.edu	37	10	64944420	64944420	+	Missense_Mutation	SNP	C	C	G			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr10:64944420C>G	uc001jmn.2	-	21	7209	c.6909G>C	c.(6907-6909)TTG>TTC	p.L2303F	JMJD1C_uc001jml.2_Missense_Mutation_p.L2066F|JMJD1C_uc001jmm.2_Missense_Mutation_p.L2015F|JMJD1C_uc010qiq.1_Missense_Mutation_p.L2121F|JMJD1C_uc009xpi.2_Missense_Mutation_p.L2121F|JMJD1C_uc009xpj.1_RNA|JMJD1C_uc001jmo.2_Missense_Mutation_p.L210F	NM_032776	NP_116165	Q15652	JHD2C_HUMAN	jumonji domain containing 1C isoform a	2303	JmjC.				blood coagulation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm	histone demethylase activity (H3-K9 specific)|metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|thyroid hormone receptor binding			ovary(4)|breast(1)|central_nervous_system(1)	6	Prostate(12;0.0119)|all_hematologic(501;0.191)					AAAATCCTGGCAAATGAGAGG	0.373			NA											4	119					0	0	0.009096	0	0
MRPS16	51021	broad.mit.edu	37	10	75010727	75010727	+	Silent	SNP	C	C	A			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr10:75010727C>A	uc001jts.1	-	3	508	c.297G>T	c.(295-297)CTG>CTT	p.L99L	DNAJC9_uc010qkg.1_5'Flank|MRPS16_uc010qkh.1_Intron|MRPS16_uc001jtt.1_RNA|uc001jtu.1_5'Flank	NM_016065	NP_057149	Q9Y3D3	RT16_HUMAN	mitochondrial ribosomal protein S16 precursor	99					translation	mitochondrial small ribosomal subunit	protein binding|structural constituent of ribosome				0	Prostate(51;0.0119)					TCATAGGATGCAGAGGGAAAA	0.428			NA											59	113					7.92265e-33	9.87886e-33	0.01441	1	0
MRPS16	51021	broad.mit.edu	37	10	75011685	75011685	+	Missense_Mutation	SNP	G	G	C			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr10:75011685G>C	uc001jts.1	-	2	321	c.110C>G	c.(109-111)GCT>GGT	p.A37G	MRPS16_uc010qkh.1_RNA|MRPS16_uc001jtt.1_RNA|uc001jtu.1_5'Flank	NM_016065	NP_057149	Q9Y3D3	RT16_HUMAN	mitochondrial ribosomal protein S16 precursor	37					translation	mitochondrial small ribosomal subunit	protein binding|structural constituent of ribosome				0	Prostate(51;0.0119)					CTTGTTGTGAGCAGCCACAAT	0.572			NA											4	28					0	0	0.007413	0	0
CYP2C8	1558	broad.mit.edu	37	10	96818250	96818250	+	Missense_Mutation	SNP	G	G	C			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr10:96818250G>C	uc001kkb.2	-	5	756	c.661C>G	c.(661-663)CTA>GTA	p.L221V	CYP2C8_uc001kkc.2_RNA|CYP2C8_uc010qoa.1_Missense_Mutation_p.L151V|CYP2C8_uc010qob.1_Missense_Mutation_p.L135V|CYP2C8_uc010qoc.1_Missense_Mutation_p.L119V|CYP2C8_uc010qod.1_Missense_Mutation_p.L135V	NM_000770	NP_000761	P10632	CP2C8_HUMAN	cytochrome P450, family 2, subfamily C,	221					exogenous drug catabolic process|organic acid metabolic process|oxidative demethylation|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|caffeine oxidase activity|electron carrier activity|heme binding|oxygen binding				0		Colorectal(252;0.0397)		all cancers(201;6.21e-05)	Aminophenazone(DB01424)|Amiodarone(DB01118)|Amodiaquine(DB00613)|Benzphetamine(DB00865)|Carbamazepine(DB00564)|Cerivastatin(DB00439)|Diclofenac(DB00586)|Fluvastatin(DB01095)|Fosphenytoin(DB01320)|Gemfibrozil(DB01241)|Ketoconazole(DB01026)|Lapatinib(DB01259)|Lovastatin(DB00227)|Midazolam(DB00683)|Montelukast(DB00471)|Nicardipine(DB00622)|Paclitaxel(DB01229)|Phenytoin(DB00252)|Pioglitazone(DB01132)|Repaglinide(DB00912)|Rifampin(DB01045)|Rosiglitazone(DB00412)|Simvastatin(DB00641)|Sitagliptin(DB01261)|Tolbutamide(DB01124)|Torasemide(DB00214)|Tretinoin(DB00755)|Trimethoprim(DB00440)|Warfarin(DB00682)|Zafirlukast(DB00549)|Zopiclone(DB01198)	TCAATGAGTAGAGGGAAATTA	0.323			NA											17	39					0	0	0.007413	0	0
SFXN3	81855	broad.mit.edu	37	10	102799248	102799248	+	Missense_Mutation	SNP	C	C	G			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr10:102799248C>G	uc001ksp.2	+	12	1340	c.884C>G	c.(883-885)TCC>TGC	p.S295C	SFXN3_uc001ksq.2_Missense_Mutation_p.S295C|SFXN3_uc010qpx.1_Missense_Mutation_p.S299C	NM_030971	NP_112233	Q9BWM7	SFXN3_HUMAN	sideroflexin 3	295					iron ion homeostasis	integral to membrane|mitochondrial membrane	cation transmembrane transporter activity			ovary(1)	1		Colorectal(252;0.234)		Epithelial(162;6.98e-09)|all cancers(201;3.55e-07)		TATTGCAGCTCCATACACATA	0.537			NA											9	239					0	0	0.010729	0	0
RAB11FIP2	22841	broad.mit.edu	37	10	119798615	119798615	+	Missense_Mutation	SNP	C	C	A			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr10:119798615C>A	uc001ldj.1	-	3	1573	c.1133G>T	c.(1132-1134)GGG>GTG	p.G378V	RAB11FIP2_uc009xyz.1_Missense_Mutation_p.G378V	NM_014904	NP_055719	Q7L804	RFIP2_HUMAN	RAB11 family interacting protein 2	378					protein transport	plasma membrane|recycling endosome membrane	protein homodimerization activity				0		Colorectal(252;0.235)		all cancers(201;0.0238)		ATCAGATCCCCCATTGTTAAG	0.348			NA											56	101					4.88482e-21	5.99839e-21	0.01441	1	0
MKI67	4288	broad.mit.edu	37	10	129902254	129902254	+	Missense_Mutation	SNP	G	G	A			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr10:129902254G>A	uc001lke.2	-	13	8045	c.7850C>T	c.(7849-7851)TCA>TTA	p.S2617L	MKI67_uc001lkf.2_Missense_Mutation_p.S2257L|MKI67_uc009yav.1_Missense_Mutation_p.S2192L|MKI67_uc009yaw.1_Missense_Mutation_p.S1767L	NM_002417	NP_002408	P46013	KI67_HUMAN	antigen identified by monoclonal antibody Ki-67	2617	14.|16 X 122 AA approximate repeats.				cell proliferation	nucleolus	ATP binding|protein C-terminus binding			ovary(4)|central_nervous_system(2)|skin(1)	7		all_epithelial(44;2.12e-05)|all_lung(145;0.00679)|Lung NSC(174;0.00998)|all_neural(114;0.0936)|Colorectal(57;0.14)|Breast(234;0.166)|Melanoma(40;0.203)				CTCAACTGCTGAGAGCTCCTC	0.507			NA											7	227					0	0	0.001984	0	0
MUC5B	727897	broad.mit.edu	37	11	1275485	1275485	+	Silent	SNP	C	C	A			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr11:1275485C>A	uc009ycr.1	+	55	16512	c.16386C>A	c.(16384-16386)GCC>GCA	p.A5462A	MUC5B_uc001ltb.2_Silent_p.A5130A	NM_017511	NP_059981	Q9HC84	MUC5B_HUMAN	SubName: Full=Mucin 5AC, oligomeric mucus/gel-forming;	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding				0		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		CTGCCACTGCCGCTGCCGCCC	0.607			NA											14	15					1.42536e-11	1.69865e-11	0.004656	1	0
ZNF195	7748	broad.mit.edu	37	11	3380816	3380816	+	Silent	SNP	G	G	A			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr11:3380816G>A	uc001lxt.2	-	6	1600	c.1422C>T	c.(1420-1422)GTC>GTT	p.V474V	uc001lxr.2_5'Flank|ZNF195_uc001lxv.2_Silent_p.V451V|ZNF195_uc001lxs.2_Silent_p.V402V|ZNF195_uc010qxr.1_Silent_p.V455V|ZNF195_uc009ydz.2_Silent_p.V429V|ZNF195_uc001lxu.2_Silent_p.V406V	NM_001130520	NP_001123992	O14628	ZN195_HUMAN	zinc finger protein 195 isoform 1	474	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Medulloblastoma(188;0.00106)|Breast(177;0.00328)|all_neural(188;0.00681)|Ovarian(85;0.00965)		BRCA - Breast invasive adenocarcinoma(625;0.0361)|LUSC - Lung squamous cell carcinoma(625;0.2)		AAGTTCTGAAGACCTTCCCAC	0.443			NA											75	107					0	0	0.01441	0	0
OR52B2	255725	broad.mit.edu	37	11	6191554	6191554	+	Missense_Mutation	SNP	C	C	T			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr11:6191554C>T	uc010qzy.1	-	1	3	c.3G>A	c.(1-3)ATG>ATA	p.M1I		NM_001004052	NP_001004052	Q96RD2	O52B2_HUMAN	olfactory receptor, family 52, subfamily B,	1	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;3.69e-08)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TGGTGTGACTCATGATGCACT	0.418	NSCLC(5;186 261 1778 7098 14207)		NA											22	40					0	0	0.00278	0	0
SLC6A5	9152	broad.mit.edu	37	11	20622793	20622793	+	Missense_Mutation	SNP	C	C	T			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr11:20622793C>T	uc001mqd.2	+	2	395	c.122C>T	c.(121-123)CCC>CTC	p.P41L	SLC6A5_uc009yic.2_5'UTR	NM_004211	NP_004202	Q9Y345	SC6A5_HUMAN	solute carrier family 6 (neurotransmitter	41	Cytoplasmic (Potential).				synaptic transmission	integral to membrane|plasma membrane	glycine:sodium symporter activity|neurotransmitter:sodium symporter activity			ovary(2)|breast(1)|skin(1)	4					Glycine(DB00145)	CAGGAGCTTCCCGCGGCTGCC	0.726			NA											3	1					0	0	0.009096	0	0
OR5AS1	219447	broad.mit.edu	37	11	55798482	55798482	+	Missense_Mutation	SNP	G	G	T			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr11:55798482G>T	uc010riw.1	+	1	588	c.588G>T	c.(586-588)CAG>CAT	p.Q196H		NM_001001921	NP_001001921	Q8N127	O5AS1_HUMAN	olfactory receptor, family 5, subfamily AS,	196	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(3)|liver(1)|skin(1)	5	Esophageal squamous(21;0.00693)					AGATCAACCAGCTTCTGCTCT	0.413			NA											165	325					4.72421e-73	6.00182e-73	0.01441	1	0
OR8H2	390151	broad.mit.edu	37	11	55873052	55873052	+	Silent	SNP	C	C	T			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr11:55873052C>T	uc010riy.1	+	1	534	c.534C>T	c.(532-534)TTC>TTT	p.F178F		NM_001005200	NP_001005200	Q8N162	OR8H2_HUMAN	olfactory receptor, family 8, subfamily H,	178	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	Esophageal squamous(21;0.00693)					ATCACTTTTTCTGTGACACTT	0.418			NA								HNSCC(53;0.14)			37	294					0	0	0.009718	0	0
OR4D9	390199	broad.mit.edu	37	11	59282631	59282631	+	Silent	SNP	G	G	A			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr11:59282631G>A	uc010rkv.1	+	1	246	c.246G>A	c.(244-246)CTG>CTA	p.L82L		NM_001004711	NP_001004711	Q8NGE8	OR4D9_HUMAN	olfactory receptor, family 4, subfamily D,	82	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						CTAAGGTCCTGATAGATCTTC	0.463			NA											7	197					0	0	0.001984	0	0
AHNAK	79026	broad.mit.edu	37	11	62292702	62292702	+	Missense_Mutation	SNP	G	G	C			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr11:62292702G>C	uc001ntl.2	-	5	9487	c.9187C>G	c.(9187-9189)CCA>GCA	p.P3063A	AHNAK_uc001ntk.1_Intron	NM_001620	NP_001611	Q09666	AHNK_HUMAN	AHNAK nucleoprotein isoform 1	3063					nervous system development	nucleus	protein binding			ovary(10)|pancreas(4)|skin(4)|upper_aerodigestive_tract(1)	19		Melanoma(852;0.155)				TTCACATCTGGAACATCAATG	0.498			NA											6	342					0	0	0.001168	0	0
SLC3A2	6520	broad.mit.edu	37	11	62656063	62656063	+	Silent	SNP	C	C	T			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr11:62656063C>T	uc001nwd.2	+	12	2015	c.1791C>T	c.(1789-1791)CTC>CTT	p.L597L	SLC3A2_uc001nwb.2_Silent_p.L628L|SLC3A2_uc001nwc.2_Silent_p.L598L|SLC3A2_uc001nwe.2_Silent_p.L566L|SLC3A2_uc001nwf.2_Silent_p.L535L|SLC3A2_uc001nwg.2_Silent_p.L496L	NM_002394	NP_002385	P08195	4F2_HUMAN	solute carrier family 3, member 2 isoform c	597	Extracellular (Potential).				blood coagulation|carbohydrate metabolic process|cell growth|cellular nitrogen compound metabolic process|leucine import|leukocyte migration|tryptophan transport	apical plasma membrane|cell surface|integral to membrane|melanosome	calcium:sodium antiporter activity|catalytic activity|cation binding|neutral amino acid transmembrane transporter activity|protein binding				0						ACCTCCTGCTCAGCACCCAGC	0.662			NA											18	62					0	0	0.008361	0	0
RPS6KA4	8986	broad.mit.edu	37	11	64128005	64128005	+	Missense_Mutation	SNP	G	G	A			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr11:64128005G>A	uc001oae.2	+	4	486	c.403G>A	c.(403-405)GAG>AAG	p.E135K	RPS6KA4_uc001oad.2_Missense_Mutation_p.E135K|RPS6KA4_uc010rnl.1_Missense_Mutation_p.E72K|RPS6KA4_uc001oaf.2_Missense_Mutation_p.E135K|RPS6KA4_uc009ypp.2_Missense_Mutation_p.E135K	NM_003942	NP_003933	O75676	KS6A4_HUMAN	ribosomal protein S6 kinase, 90kDa, polypeptide	135	Protein kinase 1.				axon guidance|histone phosphorylation|interleukin-1-mediated signaling pathway|intracellular protein kinase cascade|positive regulation of histone acetylation|positive regulation of histone phosphorylation|positive regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	ATP binding|magnesium ion binding|mitogen-activated protein kinase p38 binding|ribosomal protein S6 kinase activity			lung(3)|ovary(1)|breast(1)	5						GTACTTCAAGGAGGCTGAGGT	0.612			NA											4	13					0	0	0.001168	0	0
ACER3	55331	broad.mit.edu	37	11	76637694	76637694	+	Missense_Mutation	SNP	C	C	T			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr11:76637694C>T	uc009yum.1	+	2	301	c.197C>T	c.(196-198)TCT>TTT	p.S66F	ACER3_uc010rsg.1_Missense_Mutation_p.S24F|ACER3_uc009yul.1_RNA|ACER3_uc001oxu.2_RNA|ACER3_uc009yun.1_Missense_Mutation_p.S24F|ACER3_uc009yuo.1_5'UTR|ACER3_uc010rsh.1_Intron|ACER3_uc010rsi.1_5'UTR|ACER3_uc010rsj.1_5'UTR	NM_018367	NP_060837	Q9NUN7	ACER3_HUMAN	phytoceramidase, alkaline	66	Helical; (Potential).				ceramide metabolic process|phytosphingosine biosynthetic process|positive regulation of cell proliferation|sphingosine biosynthetic process	integral to endoplasmic reticulum membrane|integral to Golgi membrane	phytoceramidase activity				0						TACATTGCTTCTTATTTAGCA	0.378			NA											12	65					0	0	0.00245	0	0
TMEM123	114908	broad.mit.edu	37	11	102272716	102272716	+	Missense_Mutation	SNP	G	G	C			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr11:102272716G>C	uc001pha.2	-	3	800	c.379C>G	c.(379-381)CAG>GAG	p.Q127E	TMEM123_uc009yxc.2_Missense_Mutation_p.Q108E	NM_052932	NP_443164	Q8N131	PORIM_HUMAN	transmembrane protein 123 precursor	127	Thr-rich.|Extracellular (Potential).				oncosis	external side of plasma membrane|integral to membrane	receptor activity			breast(2)	2	all_cancers(8;0.00027)|all_epithelial(12;0.0021)|Lung NSC(15;0.227)	Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0033)	Epithelial(9;0.0314)|Lung(13;0.109)|all cancers(10;0.12)|LUSC - Lung squamous cell carcinoma(19;0.151)	BRCA - Breast invasive adenocarcinoma(274;0.0149)		GTTGATATCTGAGATGTGTTC	0.388			NA											15	284					0	0	0.003163	0	0
ATM	472	broad.mit.edu	37	11	108159736	108159736	+	Missense_Mutation	SNP	T	T	G			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr11:108159736T>G	uc001pkb.1	+	28	4527	c.4142T>G	c.(4141-4143)TTT>TGT	p.F1381C	ATM_uc009yxr.1_Missense_Mutation_p.F1381C|ATM_uc001pkd.3_Missense_Mutation_p.F33C|ATM_uc001pke.1_Missense_Mutation_p.F33C|ATM_uc010rvw.1_Missense_Mutation_p.F33C|ATM_uc001pkf.2_Missense_Mutation_p.F33C	NM_000051	NP_000042	Q13315	ATM_HUMAN	ataxia telangiectasia mutated isoform 1	1381	Interaction with ABL1.				cell cycle arrest|cellular response to gamma radiation|DNA damage induced protein phosphorylation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|double-strand break repair via homologous recombination|G2/M transition DNA damage checkpoint|histone mRNA catabolic process|mitotic cell cycle spindle assembly checkpoint|negative regulation of B cell proliferation|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|pre-B cell allelic exclusion|protein autophosphorylation|reciprocal meiotic recombination|replicative senescence	cytoplasmic membrane-bounded vesicle|nucleoplasm	1-phosphatidylinositol-3-kinase activity|ATP binding|DNA binding|DNA-dependent protein kinase activity|identical protein binding|protein complex binding|protein dimerization activity|protein N-terminus binding			haematopoietic_and_lymphoid_tissue(174)|lung(25)|breast(15)|large_intestine(9)|ovary(5)|kidney(5)|central_nervous_system(4)|upper_aerodigestive_tract(1)|stomach(1)|NS(1)	240		all_cancers(61;9.64e-12)|all_epithelial(67;9.97e-08)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		Epithelial(105;9.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.06e-05)|all cancers(92;0.000208)|Colorectal(284;0.116)|OV - Ovarian serous cystadenocarcinoma(223;0.147)		CCACCTCATTTTCCATCGCAT	0.348			NA	D|Mis|N|F|S		T-PLL	leukemia|lymphoma|medulloblastoma|glioma		Genes_defective_in_diseases_associated_with_sensitivity_to_DNA_damaging_agents	Ataxia_Telangiectasia	TSP Lung(14;0.12)			4	121					0	0	0.001168	0	0
EXPH5	23086	broad.mit.edu	37	11	108412521	108412521	+	Missense_Mutation	SNP	C	C	G			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr11:108412521C>G	uc001pkk.2	-	2	249	c.138G>C	c.(136-138)AAG>AAC	p.K46N	EXPH5_uc010rwa.1_5'UTR	NM_015065	NP_055880	Q8NEV8	EXPH5_HUMAN	exophilin 5 isoform a	46					intracellular protein transport		Rab GTPase binding			skin(3)|ovary(2)	5		all_cancers(61;3.99e-08)|Acute lymphoblastic leukemia(157;3.97e-05)|Melanoma(852;4.04e-05)|all_epithelial(67;0.000116)|all_hematologic(158;0.000315)|Breast(348;0.104)|all_neural(303;0.16)		Epithelial(105;8.1e-06)|BRCA - Breast invasive adenocarcinoma(274;1.22e-05)|all cancers(92;0.000129)|OV - Ovarian serous cystadenocarcinoma(223;0.11)|Colorectal(284;0.184)		TGATATCCCTCTTTGTCTTCT	0.303			NA											4	136					0	0	0.000602	0	0
VPS11	55823	broad.mit.edu	37	11	118948942	118948942	+	Silent	SNP	C	C	T			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr11:118948942C>T	uc010ryx.1	+	12	1863	c.1821C>T	c.(1819-1821)TTC>TTT	p.F607F	VPS11_uc010ryy.1_Silent_p.F453F	NM_021729	NP_068375	Q9H270	VPS11_HUMAN	vacuolar protein sorting 11	607					protein transport	endocytic vesicle|HOPS complex|late endosome membrane|lysosomal membrane	nucleotide binding|protein binding|zinc ion binding			ovary(2)|central_nervous_system(1)	3	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.88e-05)		TGAAAGCCTTCCTAGAGCACA	0.552			NA											9	267					0	0	0.008291	0	0
GRIK4	2900	broad.mit.edu	37	11	120852826	120852826	+	Missense_Mutation	SNP	G	G	C			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr11:120852826G>C	uc001pxn.2	+	20	2694	c.2407G>C	c.(2407-2409)GAG>CAG	p.E803Q	GRIK4_uc009zaw.1_Missense_Mutation_p.E803Q|GRIK4_uc009zax.1_Missense_Mutation_p.E803Q	NM_014619	NP_055434	Q16099	GRIK4_HUMAN	glutamate receptor KA1 precursor	803	Extracellular (Potential).				glutamate signaling pathway|synaptic transmission	cell junction|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			ovary(2)|central_nervous_system(1)	3		Breast(109;0.000868)|Medulloblastoma(222;0.0453)|all_neural(223;0.116)|all_hematologic(192;0.21)		BRCA - Breast invasive adenocarcinoma(274;1.24e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.116)	L-Glutamic Acid(DB00142)	CCTGGGAATGGAGAATATTGG	0.338			NA											6	323					0	0	0.001168	0	0
SORL1	6653	broad.mit.edu	37	11	121420743	121420743	+	Missense_Mutation	SNP	C	C	T			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr11:121420743C>T	uc001pxx.2	+	15	2206	c.2126C>T	c.(2125-2127)TCA>TTA	p.S709L		NM_003105	NP_003096	Q92673	SORL_HUMAN	sortilin-related receptor containing LDLR class	709	Extracellular (Potential).				cholesterol metabolic process|lipid transport|receptor-mediated endocytosis	integral to plasma membrane|low-density lipoprotein particle	low-density lipoprotein particle binding|transmembrane receptor activity			ovary(5)|breast(4)|large_intestine(2)|skin(2)|central_nervous_system(1)|pancreas(1)	15		Breast(109;0.00119)|Medulloblastoma(222;0.0429)|all_neural(223;0.113)		BRCA - Breast invasive adenocarcinoma(274;3.34e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.108)		TCTGGAAAGTCATACTCCCCT	0.473			NA											8	112					0	0	0.004482	0	0
KCNJ5	3762	broad.mit.edu	37	11	128781480	128781480	+	Silent	SNP	C	C	T			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr11:128781480C>T	uc001qet.2	+	2	626	c.312C>T	c.(310-312)TTC>TTT	p.F104F	KCNJ5_uc009zck.2_Silent_p.F104F|KCNJ5_uc001qew.2_Silent_p.F104F	NM_000890	NP_000881	P48544	IRK5_HUMAN	potassium inwardly-rectifying channel J5	104	Helical; Name=M1; (By similarity).				synaptic transmission	voltage-gated potassium channel complex	G-protein activated inward rectifier potassium channel activity|protein binding			skin(1)	1	all_hematologic(175;0.0641)	Lung NSC(97;0.00038)|all_lung(97;0.000817)|Breast(109;0.00123)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.0059)|LUSC - Lung squamous cell carcinoma(976;0.021)|Lung(977;0.0215)	Glibenclamide(DB01016)	GGCTGTTCTTCGGCTTCATTT	0.527	Pancreas(108;2548 5082)|Esophageal Squamous(165;4544 6231)		NA											12	120					0	0	0.001855	0	0
GALNT8	26290	broad.mit.edu	37	12	4870202	4870202	+	Missense_Mutation	SNP	G	G	T			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr12:4870202G>T	uc001qne.1	+	7	1344	c.1252G>T	c.(1252-1254)GCC>TCC	p.A418S		NM_017417	NP_059113	Q9NY28	GALT8_HUMAN	polypeptide N-acetylgalactosaminyltransferase 8	418	Lumenal (Potential).					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			ovary(2)|pancreas(1)|skin(1)	4						CAAGCCCTACGCCTTGGATCT	0.537	Colon(108;631 1558 7270 20097 39846)		NA											49	65					2.9001e-28	3.60505e-28	0.01441	1	0
TAS2R31	259290	broad.mit.edu	37	12	11183031	11183032	+	Missense_Mutation	DNP	TC	TC	CA			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	TC	TC	-	-	TC	TC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr12:11183031_11183032TC>CA	uc001qzo.1	-	1	975_976	c.903_904GA>TG	c.(901-906)GTGAAA>GTTGAA	p.K302E	PRR4_uc009zhp.2_Intron|PRH1_uc001qzb.3_Intron|PRH1_uc001qzc.2_Intron|PRB4_uc001qzf.1_Intron|PRH1_uc001qzj.2_Intron	NM_176885	NP_795366	P59538	T2R31_HUMAN	taste receptor, type 2, member 31	302	Cytoplasmic (Potential).				sensory perception of taste	integral to membrane	G-protein coupled receptor activity				0						TTCTCTCCTTTCACCCAGTACC	0.411			NA											7	225					0	0	0.004672	0	0
GPRC5A	9052	broad.mit.edu	37	12	13065462	13065462	+	Missense_Mutation	SNP	G	G	C			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr12:13065462G>C	uc001rba.2	+	4	1713	c.1063G>C	c.(1063-1065)GAG>CAG	p.E355Q	uc001rbb.3_5'Flank	NM_003979	NP_003970	Q8NFJ5	RAI3_HUMAN	G protein-coupled receptor, family C, group 5,	355	Cytoplasmic (Potential).					cytoplasmic vesicle membrane|Golgi apparatus|integral to plasma membrane	G-protein coupled receptor activity				0		Prostate(47;0.141)		BRCA - Breast invasive adenocarcinoma(232;0.0708)	Tretinoin(DB00755)	AGTAAAGAAAGAGGGCAGCTA	0.527			NA											4	170					0	0	0.000602	0	0
KRT75	9119	broad.mit.edu	37	12	52826902	52826902	+	Silent	SNP	C	C	T			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr12:52826902C>T	uc001saj.2	-	2	655	c.633G>A	c.(631-633)CTG>CTA	p.L211L		NM_004693	NP_004684	O95678	K2C75_HUMAN	keratin 75	211	Coil 1B.|Rod.					keratin filament	structural molecule activity				0				BRCA - Breast invasive adenocarcinoma(357;0.192)		TGATGCTTTCCAGCTGCCGTC	0.557			NA											5	176					0	0	0.000602	0	0
SP1	6667	broad.mit.edu	37	12	53777321	53777321	+	Silent	SNP	G	G	A			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr12:53777321G>A	uc001scw.2	+	3	1687	c.1590G>A	c.(1588-1590)CAG>CAA	p.Q530Q	SP1_uc010sog.1_Silent_p.Q523Q	NM_138473	NP_612482	P08047	SP1_HUMAN	Sp1 transcription factor isoform a	530	Transactivation domain C (highly charged).				positive regulation by host of viral transcription|positive regulation of transcription from RNA polymerase II promoter	cytoplasm	double-stranded DNA binding|histone deacetylase binding|HMG box domain binding|protein C-terminus binding|protein homodimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription regulatory region DNA binding|zinc ion binding			ovary(1)|breast(1)|skin(1)	3				BRCA - Breast invasive adenocarcinoma(357;0.00527)		CAGGCCTCCAGACCATTAACC	0.532			NA											5	177					0	0	0.001984	0	0
PDE1B	5153	broad.mit.edu	37	12	54968907	54968907	+	Missense_Mutation	SNP	C	C	G			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr12:54968907C>G	uc001sgd.1	+	11	1256	c.1090C>G	c.(1090-1092)CTA>GTA	p.L364V	PDE1B_uc010soz.1_Missense_Mutation_p.L227V|PDE1B_uc010spa.1_Missense_Mutation_p.L323V|PDE1B_uc001sgf.2_Missense_Mutation_p.L227V|PDE1B_uc001sge.2_Missense_Mutation_p.L344V|PDE1B_uc009znq.2_Missense_Mutation_p.L160V	NM_000924	NP_000915	Q01064	PDE1B_HUMAN	phosphodiesterase 1B isoform 1	364	Catalytic (By similarity).				activation of phospholipase C activity|apoptosis|nerve growth factor receptor signaling pathway|platelet activation	cytosol|nucleus	3',5'-cyclic-AMP phosphodiesterase activity|calmodulin binding|calmodulin-dependent cyclic-nucleotide phosphodiesterase activity|metal ion binding			upper_aerodigestive_tract(1)|ovary(1)	2						GGCCCTGTCTCTACTGCTCCA	0.542			NA											5	135					0	0	0.001168	0	0
BAZ2A	11176	broad.mit.edu	37	12	57009066	57009066	+	Missense_Mutation	SNP	A	A	T			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr12:57009066A>T	uc001slq.1	-	3	662	c.468T>A	c.(466-468)AGT>AGA	p.S156R	BAZ2A_uc001slp.1_Missense_Mutation_p.S154R|BAZ2A_uc010sqr.1_Missense_Mutation_p.S156R|BAZ2A_uc009zow.1_Missense_Mutation_p.S154R	NM_013449	NP_038477	Q9UIF9	BAZ2A_HUMAN	bromodomain adjacent to zinc finger domain, 2A	156					chromatin silencing at rDNA|DNA methylation|transcription, DNA-dependent	chromatin silencing complex|nucleolus|rDNA heterochromatin	DNA binding|histone acetyl-lysine binding|ligand-dependent nuclear receptor binding|RNA binding|zinc ion binding				0						GCCCCATGGGACTCTGGGTAC	0.522			NA											24	41					0	0	0.00333	0	0
INHBE	83729	broad.mit.edu	37	12	57850041	57850041	+	Missense_Mutation	SNP	C	C	T			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr12:57850041C>T	uc001snw.2	+	2	687	c.463C>T	c.(463-465)CGC>TGC	p.R155C		NM_031479	NP_113667	P58166	INHBE_HUMAN	activin beta E precursor	155					growth	extracellular region	growth factor activity|hormone activity			breast(2)|central_nervous_system(1)	3						CCAAGGGTCCCGCACTCTCCT	0.602	GBM(191;1808 2166 15720 36624 50371)		NA									OREG0021944	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	152	238					0	0	0.01441	0	0
DDIT3	1649	broad.mit.edu	37	12	57910715	57910715	+	Missense_Mutation	SNP	C	C	G			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr12:57910715C>G	uc001soi.2	-	4	567	c.387G>C	c.(385-387)AGG>AGC	p.R129S	MARS_uc001sof.1_Intron|DDIT3_uc009zps.2_Missense_Mutation_p.R152S|DDIT3_uc009zpt.2_Missense_Mutation_p.R152S	NM_004083	NP_004074	P35638	DDIT3_HUMAN	DNA-damage-inducible transcript 3	129					cell cycle arrest|cell redox homeostasis|mRNA transcription from RNA polymerase II promoter|negative regulation of determination of dorsal identity|regulation of DNA-dependent transcription in response to stress|response to DNA damage stimulus	nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|transcription factor binding		FUS/DDIT3(623)|EWSR1/DDIT3(43)	soft_tissue(666)|large_intestine(1)|central_nervous_system(1)|lung(1)|skin(1)|ovary(1)	671						GTGCCACTTTCCTTTCATTCT	0.542	GBM(112;1383 1547 7626 23045 28770)		NA	T	FUS	liposarcoma								4	272					0	0	0.009096	0	0
CCT2	10576	broad.mit.edu	37	12	69993722	69993722	+	Silent	SNP	G	G	C			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr12:69993722G>C	uc001svb.1	+	15	1609	c.1515G>C	c.(1513-1515)CTG>CTC	p.L505L	CCT2_uc009zrm.1_RNA|CCT2_uc009zrn.1_Intron|CCT2_uc010stl.1_Silent_p.L458L	NM_006431	NP_006422	P78371	TCPB_HUMAN	chaperonin containing TCP1, subunit 2	505					'de novo' posttranslational protein folding	nucleus	ATP binding|unfolded protein binding			ovary(1)|central_nervous_system(1)|skin(1)	3	all_cancers(2;7.7e-106)|Breast(13;2.15e-06)|Esophageal squamous(21;0.187)		Epithelial(6;2.72e-18)|GBM - Glioblastoma multiforme(2;2.58e-10)|Lung(24;0.000185)|OV - Ovarian serous cystadenocarcinoma(12;0.00126)|STAD - Stomach adenocarcinoma(21;0.00501)|Kidney(9;0.143)|LUSC - Lung squamous cell carcinoma(43;0.24)			AGGTTCTTCTGAGTGCAGCTG	0.433			NA											5	84					0	0	0.001168	0	0
ACTR6	64431	broad.mit.edu	37	12	100606231	100606231	+	Silent	SNP	G	G	A			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr12:100606231G>A	uc001thb.1	+	8	731	c.675G>A	c.(673-675)TTG>TTA	p.L225L	ACTR6_uc001thc.1_Silent_p.L117L|ACTR6_uc001thd.1_Silent_p.L225L|ACTR6_uc009ztu.1_Silent_p.L30L|ACTR6_uc001the.1_Silent_p.L143L|ACTR6_uc001thf.1_Silent_p.L143L|uc001thg.1_Intron	NM_022496	NP_071941	Q9GZN1	ARP6_HUMAN	ARP6 actin-related protein 6 homolog	225						cytoplasm|cytoskeleton				ovary(1)	1						TTTCCAGGTTGAAAGGAGAAG	0.289			NA											4	119					0	0	0.009096	0	0
DEPDC4	120863	broad.mit.edu	37	12	100649949	100649949	+	Missense_Mutation	SNP	G	G	C			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr12:100649949G>C	uc001thi.2	-	4	759	c.756C>G	c.(754-756)TTC>TTG	p.F252L	DEPDC4_uc001thh.1_RNA|DEPDC4_uc001thj.1_Missense_Mutation_p.F198L|DEPDC4_uc009ztv.1_Missense_Mutation_p.F252L|DEPDC4_uc001thk.1_Missense_Mutation_p.F63L|DEPDC4_uc001thl.1_RNA	NM_152317	NP_689530	Q8N2C3	DEPD4_HUMAN	DEP domain containing 4	252					intracellular signal transduction						0						TATTGTCCAAGAATGGAAGGT	0.323			NA											4	83					0	0	0.009096	0	0
ARPC3	10094	broad.mit.edu	37	12	110874419	110874419	+	Missense_Mutation	SNP	C	C	G			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr12:110874419C>G	uc001tqq.2	-	5	415	c.322G>C	c.(322-324)GAG>CAG	p.E108Q		NM_005719	NP_005710	O15145	ARPC3_HUMAN	actin related protein 2/3 complex subunit 3	108					cellular component movement|regulation of actin filament polymerization	Arp2/3 protein complex|cytoplasm	actin binding|structural constituent of cytoskeleton			ovary(1)	1						AAACCAGGCTCTCCAGGAATG	0.368			NA											4	253					0	0	0.000602	0	0
SKA3	221150	broad.mit.edu	37	13	21742491	21742491	+	Missense_Mutation	SNP	C	C	G			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr13:21742491C>G	uc001unt.2	-	4	473	c.379G>C	c.(379-381)GAA>CAA	p.E127Q	SKA3_uc001unv.2_Missense_Mutation_p.E45Q|SKA3_uc001unu.2_Missense_Mutation_p.E127Q	NM_145061	NP_659498	Q8IX90	SKA3_HUMAN	SKA3	127					cell division|chromosome segregation|mitosis|regulation of microtubule polymerization or depolymerization	condensed chromosome outer kinetochore|cytoplasm|spindle microtubule	protein binding				0						TGAAAATTTTCACAATTAGAC	0.393			NA											3	115					0	0	0.009096	0	0
CENPJ	55835	broad.mit.edu	37	13	25480067	25480067	+	Missense_Mutation	SNP	G	G	C			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr13:25480067G>C	uc001upt.3	-	7	2362	c.2109C>G	c.(2107-2109)AGC>AGG	p.S703R	CENPJ_uc010tdf.1_RNA|CENPJ_uc010aae.2_RNA|CENPJ_uc010aaf.2_RNA|CENPJ_uc001upu.2_5'Flank	NM_018451	NP_060921	Q9HC77	CENPJ_HUMAN	centromere protein J	703					cell division|centriole replication|G2/M transition of mitotic cell cycle|microtubule nucleation|microtubule polymerization	centriole|cytosol|gamma-tubulin small complex|microtubule	protein domain specific binding|tubulin binding			ovary(2)	2		Lung SC(185;0.0225)|Breast(139;0.0602)		all cancers(112;0.00793)|Epithelial(112;0.0411)|OV - Ovarian serous cystadenocarcinoma(117;0.139)		CAGAGTCAGTGCTACTGTCAC	0.463			NA											4	118					0	0	0.000602	0	0
BRCA2	675	broad.mit.edu	37	13	32913027	32913027	+	Missense_Mutation	SNP	G	G	A	rs80358685		TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr13:32913027G>A	uc001uub.1	+	11	4762	c.4535G>A	c.(4534-4536)CGT>CAT	p.R1512H		NM_000059	NP_000050	P51587	BRCA2_HUMAN	breast cancer 2, early onset	1512					cell cycle cytokinesis|centrosome duplication|double-strand break repair via homologous recombination|negative regulation of mammary gland epithelial cell proliferation|nucleotide-excision repair|positive regulation of transcription, DNA-dependent|regulation of S phase of mitotic cell cycle	BRCA2-MAGE-D1 complex|centrosome|nucleoplasm|stored secretory granule	gamma-tubulin binding|H3 histone acetyltransferase activity|H4 histone acetyltransferase activity|protease binding|single-stranded DNA binding			ovary(20)|endometrium(8)|lung(7)|breast(7)|oesophagus(5)|large_intestine(4)|central_nervous_system(3)|pancreas(3)|skin(2)|upper_aerodigestive_tract(1)|cervix(1)|salivary_gland(1)|liver(1)|kidney(1)	64		Lung SC(185;0.0262)		all cancers(112;7.13e-07)|Epithelial(112;1.59e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.000732)|BRCA - Breast invasive adenocarcinoma(63;0.0291)|GBM - Glioblastoma multiforme(144;0.0704)		CAACCCGAACGTGATGAAAAG	0.378	Esophageal Squamous(138;838 1285 7957 30353 30468 36915 49332)		NA	D|Mis|N|F|S		breast|ovarian|pancreatic	breast|ovarian|pancreatic|leukemia  (FANCB|FANCD1)		Direct_reversal_of_damage|Homologous_recombination	FanconAnemia_type_D1_bi-allelic_BRCA2_mutations|Fanconi_Anemia|Pancreatic_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_BRCA2_type|Hereditary_Prostate_Cancer|Li-Fraumeni_syndrome	TCGA Ovarian(8;0.087)			4	58					0	0	0.009096	0	0
RCBTB1	55213	broad.mit.edu	37	13	50123709	50123709	+	Missense_Mutation	SNP	C	C	G			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr13:50123709C>G	uc001vde.1	-	9	1191	c.930G>C	c.(928-930)TGG>TGC	p.W310C		NM_018191	NP_060661	Q8NDN9	RCBT1_HUMAN	regulator of chromosome condensation (RCC1) and	310	RCC1 6.				cell cycle|chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus				ovary(1)	1		Lung NSC(96;2.1e-05)|Breast(56;0.00015)|Prostate(109;0.00314)|Hepatocellular(98;0.0207)|Myeloproliferative disorder(33;0.163)|Lung SC(185;0.187)|all_neural(104;0.19)	KIRC - Kidney renal clear cell carcinoma(9;0.206)	GBM - Glioblastoma multiforme(99;4.7e-09)		GGCACTGGCCCCACATGTACA	0.592			NA											11	51					0	0	0.010729	0	0
KLF12	11278	broad.mit.edu	37	13	74387368	74387368	+	Missense_Mutation	SNP	C	C	T			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr13:74387368C>T	uc001vjf.2	-	5	949	c.727G>A	c.(727-729)GAT>AAT	p.D243N	KLF12_uc010aeq.2_Missense_Mutation_p.D243N|KLF12_uc001vjg.3_Missense_Mutation_p.D243N	NM_007249	NP_009180	Q9Y4X4	KLF12_HUMAN	Kruppel-like factor 12	243					negative regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			ovary(1)	1		Prostate(6;0.00217)|Breast(118;0.0838)		GBM - Glioblastoma multiforme(99;0.00677)		GGCAGGTCATCATCATCACTG	0.438			NA											6	141					0	0	0.001984	0	0
FBXL3	26224	broad.mit.edu	37	13	77589622	77589622	+	Missense_Mutation	SNP	G	G	C			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr13:77589622G>C	uc001vkd.2	-	4	936	c.565C>G	c.(565-567)CTC>GTC	p.L189V		NM_012158	NP_036290	Q9UKT7	FBXL3_HUMAN	F-box and leucine-rich repeat protein 3	189	LRR 2.				regulation of circadian rhythm|rhythmic process|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	cytoplasm|nucleus|SCF ubiquitin ligase complex	protein binding|ubiquitin-protein ligase activity				0		Breast(118;0.212)|Acute lymphoblastic leukemia(28;0.218)		GBM - Glioblastoma multiforme(99;0.0521)		AGTACTTTGAGAGATGGATCA	0.413			NA											21	116					0	0	0.00278	0	0
ABCC4	10257	broad.mit.edu	37	13	95735399	95735399	+	Missense_Mutation	SNP	G	G	C			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr13:95735399G>C	uc001vmd.3	-	21	2800	c.2681C>G	c.(2680-2682)TCT>TGT	p.S894C	ABCC4_uc010afk.2_Missense_Mutation_p.S847C	NM_005845	NP_005836	O15439	MRP4_HUMAN	ATP-binding cassette, sub-family C, member 4	894	ABC transmembrane type-1 2.				platelet activation|platelet degranulation	integral to membrane|membrane fraction|plasma membrane|platelet dense granule membrane	15-hydroxyprostaglandin dehydrogenase (NAD+) activity|ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|chloride channel activity			central_nervous_system(3)|skin(1)	4	all_neural(89;0.0878)|Medulloblastoma(90;0.163)				Cefazolin(DB01327)	CTCACTTGTAGATTCCAGGCG	0.428			NA											4	125					0	0	0.000602	0	0
ATP11A	23250	broad.mit.edu	37	13	113514624	113514624	+	Silent	SNP	G	G	A			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr13:113514624G>A	uc001vsi.3	+	24	2839	c.2751G>A	c.(2749-2751)CTG>CTA	p.L917L	ATP11A_uc001vsj.3_Silent_p.L917L|ATP11A_uc001vsm.1_Silent_p.L793L|ATP11A_uc010ago.2_Intron	NM_015205	NP_056020	P98196	AT11A_HUMAN	ATPase, class VI, type 11A isoform a	917	Helical; (Potential).				ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			large_intestine(2)|ovary(2)	4	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)	all_lung(25;0.134)|all_epithelial(44;0.141)				CCGCGTATCTGACCCTCTACA	0.468			NA											6	194					0	0	0.001984	0	0
COCH	1690	broad.mit.edu	37	14	31349863	31349863	+	Silent	SNP	G	G	A			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr14:31349863G>A	uc001wqr.2	+	8	632	c.552G>A	c.(550-552)CAG>CAA	p.Q184Q	COCH_uc001wqp.2_Silent_p.Q184Q|COCH_uc001wqq.3_Silent_p.Q184Q|uc001wqs.2_Intron|COCH_uc001wqt.1_5'UTR	NM_004086	NP_004077	O43405	COCH_HUMAN	cochlin precursor	184	VWFA 1.				sensory perception of sound	proteinaceous extracellular matrix				pancreas(1)|central_nervous_system(1)|skin(1)	3	Hepatocellular(127;0.0877)|Breast(36;0.148)		LUAD - Lung adenocarcinoma(48;0.00192)|Lung(238;0.0119)|BRCA - Breast invasive adenocarcinoma(188;0.0805)	GBM - Glioblastoma multiforme(265;0.00645)		TTAATTTACAGAAGAATTTTG	0.418			NA											5	257					0	0	0.001168	0	0
SDCCAG1	9147	broad.mit.edu	37	14	50267175	50267175	+	Missense_Mutation	SNP	C	C	G			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr14:50267175C>G	uc001wxc.2	-	23	2403	c.2335G>C	c.(2335-2337)GAT>CAT	p.D779H	SDCCAG1_uc010anj.1_Missense_Mutation_p.D779H|SDCCAG1_uc001wwz.2_5'Flank|SDCCAG1_uc001wxa.2_Missense_Mutation_p.D59H|SDCCAG1_uc010tqi.1_Missense_Mutation_p.D758H|SDCCAG1_uc001wxe.2_Missense_Mutation_p.D737H|SDCCAG1_uc001wxd.1_Missense_Mutation_p.D184H	NM_004713	NP_004704	O60524	NEMF_HUMAN	serologically defined colon cancer antigen 1	779						cytoplasm|nucleus					0	all_epithelial(31;0.000822)|Breast(41;0.0117)	all_lung(585;1.02e-05)		OV - Ovarian serous cystadenocarcinoma(311;5.99e-34)		ATGGTAGTATCAGGATAATTT	0.343			NA											3	105					0	0	0.004672	0	0
SIPA1L1	26037	broad.mit.edu	37	14	72152196	72152196	+	Missense_Mutation	SNP	G	G	T			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr14:72152196G>T	uc001xms.2	+	10	3570	c.3222G>T	c.(3220-3222)AAG>AAT	p.K1074N	SIPA1L1_uc001xmt.2_Missense_Mutation_p.K1074N|SIPA1L1_uc001xmu.2_Missense_Mutation_p.K1074N|SIPA1L1_uc001xmv.2_Missense_Mutation_p.K1074N|SIPA1L1_uc010ttm.1_Missense_Mutation_p.K549N	NM_015556	NP_056371	O43166	SI1L1_HUMAN	signal-induced proliferation-associated 1 like	1074					actin cytoskeleton reorganization|activation of Rap GTPase activity|regulation of dendritic spine morphogenesis	cell junction|cytoplasm|dendritic spine|postsynaptic density|postsynaptic membrane|synaptosome	GTPase activator activity			ovary(3)|breast(1)	4				all cancers(60;0.00169)|BRCA - Breast invasive adenocarcinoma(234;0.00912)|OV - Ovarian serous cystadenocarcinoma(108;0.0109)		ACGCCAGCAAGGGGCCTCATT	0.507			NA											86	56					5.02048e-33	6.27949e-33	0.01441	1	0
SERPINA4	5267	broad.mit.edu	37	14	95033575	95033575	+	Silent	SNP	G	G	A			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr14:95033575G>A	uc001ydk.2	+	3	984	c.918G>A	c.(916-918)CGG>CGA	p.R306R	SERPINA4_uc010avd.2_Silent_p.R343R|SERPINA4_uc001ydl.2_Silent_p.R306R	NM_006215	NP_006206	P29622	KAIN_HUMAN	serine (or cysteine) proteinase inhibitor, clade	306					regulation of proteolysis	extracellular space	serine-type endopeptidase inhibitor activity			ovary(3)|skin(1)	4				COAD - Colon adenocarcinoma(157;0.211)		ACTTGTTGCGGAAGAGGTAAT	0.438			NA											4	114					0	0	0.000602	0	0
AHNAK2	113146	broad.mit.edu	37	14	105413013	105413013	+	Silent	SNP	C	C	T			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr14:105413013C>T	uc010axc.1	-	7	8895	c.8775G>A	c.(8773-8775)CTG>CTA	p.L2925L	AHNAK2_uc001ypx.2_Silent_p.L2825L	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	2925						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			TGGGGCCTTTCAGGTCCAGCT	0.632			NA											16	388					0	0	0.004007	0	0
AHNAK2	113146	broad.mit.edu	37	14	105413043	105413043	+	Missense_Mutation	SNP	C	C	G			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr14:105413043C>G	uc010axc.1	-	7	8865	c.8745G>C	c.(8743-8745)CAG>CAC	p.Q2915H	AHNAK2_uc001ypx.2_Missense_Mutation_p.Q2815H	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	2915						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			TGACGTCTATCTGGGGGCCCT	0.652			NA											17	420					0	0	0.006122	0	0
GABRB3	2562	broad.mit.edu	37	15	26793029	26793029	+	Missense_Mutation	SNP	C	C	T			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr15:26793029C>T	uc001zaz.2	-	9	1475	c.1333G>A	c.(1333-1335)GTG>ATG	p.V445M	GABRB3_uc010uae.1_Missense_Mutation_p.V360M|GABRB3_uc001zba.2_Missense_Mutation_p.V445M|GABRB3_uc001zbb.2_Missense_Mutation_p.V501M	NM_000814	NP_000805	P28472	GBRB3_HUMAN	gamma-aminobutyric acid (GABA) A receptor, beta	445	Cytoplasmic (Probable).				synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			upper_aerodigestive_tract(1)|ovary(1)|lung(1)|liver(1)|central_nervous_system(1)	5		all_cancers(20;1.89e-22)|all_lung(180;6.35e-15)|Breast(32;0.000279)|Colorectal(260;0.232)		all cancers(64;1.46e-07)|Epithelial(43;2.89e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0251)|COAD - Colon adenocarcinoma(236;0.235)|Lung(196;0.243)	Ethchlorvynol(DB00189)|Flurazepam(DB00690)|Lorazepam(DB00186)|Midazolam(DB00683)	ATGGCATTCACATCGGTTAGA	0.453			NA											44	87					0	0	0.01441	0	0
BUB1B	701	broad.mit.edu	37	15	40505533	40505533	+	Missense_Mutation	SNP	G	G	A			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr15:40505533G>A	uc001zkx.3	+	20	2748	c.2536G>A	c.(2536-2538)GAT>AAT	p.D846N		NM_001211	NP_001202	O60566	BUB1B_HUMAN	budding uninhibited by benzimidazoles 1 beta	846	Protein kinase.				anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|cell division|cell proliferation|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|phosphatidylinositol-mediated signaling|protein localization to kinetochore|spindle organization	anaphase-promoting complex|condensed chromosome outer kinetochore|cytosol|microtubule organizing center|perinuclear region of cytoplasm|spindle midzone	ATP binding|protein binding|protein serine/threonine kinase activity			stomach(2)|ovary(1)|kidney(1)	4		all_cancers(109;1.12e-18)|all_epithelial(112;1.61e-15)|Lung NSC(122;5.63e-11)|all_lung(180;1.4e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;1.83e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0556)		CAATTTCCAGGATCTTCTCCA	0.348			NA	Mis|N|F|S			rhabdomyosarcoma			Mosaic_Variegated_Aneuploidy_Syndrome				32	59					0	0	0.003271	0	0
OIP5	11339	broad.mit.edu	37	15	41624440	41624440	+	Missense_Mutation	SNP	G	G	A			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr15:41624440G>A	uc001znp.2	-	1	380	c.320C>T	c.(319-321)TCC>TTC	p.S107F	NUSAP1_uc001znq.3_5'Flank|NUSAP1_uc001znr.3_5'Flank|NUSAP1_uc001zns.3_5'Flank|NUSAP1_uc010bce.2_5'Flank|NUSAP1_uc001znt.3_5'Flank|NUSAP1_uc001znv.3_5'Flank|NUSAP1_uc001znu.3_5'Flank|NUSAP1_uc010ucw.1_5'Flank	NM_007280	NP_009211	O43482	MS18B_HUMAN	Opa interacting protein 5	107					cell communication|cell division|CenH3-containing nucleosome assembly at centromere|mitosis	Cajal body|chromatin|chromosome, centromeric region	protein binding				0		all_cancers(109;4.16e-14)|all_epithelial(112;7.09e-12)|Lung NSC(122;1.14e-09)|all_lung(180;2.56e-08)|Melanoma(134;0.091)|Colorectal(260;0.175)		OV - Ovarian serous cystadenocarcinoma(18;1.49e-16)|GBM - Glioblastoma multiforme(113;1.29e-06)|BRCA - Breast invasive adenocarcinoma(123;0.163)		GCACTCACTGGAGAAGACCAC	0.647			NA									OREG0023073	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	8	54					0	0	0.004482	0	0
JMJD7-PLA2G4B	8681	broad.mit.edu	37	15	42139578	42139578	+	Missense_Mutation	SNP	C	C	T	rs145043086		TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr15:42139578C>T	uc010bco.2	+	19	2092	c.1991C>T	c.(1990-1992)CCG>CTG	p.P664L	JMJD7-PLA2G4B_uc001zoo.3_Missense_Mutation_p.P895L|JMJD7-PLA2G4B_uc010bcn.2_Intron|JMJD7-PLA2G4B_uc001zoq.3_Missense_Mutation_p.P365L	NM_001114633	NP_001108105	P0C869	PA24B_HUMAN	phospholipase A2, group IVB	664	PLA2c.				arachidonic acid metabolic process|calcium-mediated signaling|glycerophospholipid catabolic process|inflammatory response|parturition	cytosol|early endosome membrane|extracellular region|mitochondrial membrane	calcium ion binding|calcium-dependent phospholipase A2 activity|calcium-dependent phospholipid binding|lysophospholipase activity			large_intestine(1)	1						CAGGGGATCCCGTTCCCACCC	0.687			NA											50	129					0	0	0.01441	0	0
LCMT2	9836	broad.mit.edu	37	15	43620678	43620678	+	Missense_Mutation	SNP	G	G	C			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr15:43620678G>C	uc001zrg.2	-	1	2214	c.2010C>G	c.(2008-2010)TTC>TTG	p.F670L	LCMT2_uc010udn.1_Missense_Mutation_p.F249L|ADAL_uc001zrh.2_5'Flank|ADAL_uc010udo.1_5'Flank	NM_014793	NP_055608	O60294	LCMT2_HUMAN	leucine carboxyl methyltransferase 2	670					tRNA processing		methyltransferase activity|protein binding				0		all_cancers(109;2.12e-14)|all_epithelial(112;1.99e-12)|Lung NSC(122;2.46e-08)|all_lung(180;2.75e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;8.1e-07)	L-Leucine(DB00149)	TATGGGGGTTGAAGTAGGTAC	0.438			NA											16	132					0	0	0.00499	0	0
LCMT2	9836	broad.mit.edu	37	15	43622436	43622436	+	Missense_Mutation	SNP	C	C	G			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr15:43622436C>G	uc001zrg.2	-	1	456	c.252G>C	c.(250-252)CAG>CAC	p.Q84H	LCMT2_uc010udn.1_Intron|ADAL_uc001zrh.2_5'Flank|ADAL_uc010udo.1_5'Flank	NM_014793	NP_055608	O60294	LCMT2_HUMAN	leucine carboxyl methyltransferase 2	84					tRNA processing		methyltransferase activity|protein binding				0		all_cancers(109;2.12e-14)|all_epithelial(112;1.99e-12)|Lung NSC(122;2.46e-08)|all_lung(180;2.75e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;8.1e-07)	L-Leucine(DB00149)	GAGACAAGATCTGCGCGCGAA	0.647			NA											4	50					0	0	0.000602	0	0
GCNT3	9245	broad.mit.edu	37	15	59910672	59910672	+	Missense_Mutation	SNP	G	G	C	rs143474619		TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr15:59910672G>C	uc002age.2	+	3	684	c.235G>C	c.(235-237)GAG>CAG	p.E79Q	GCNT3_uc002agd.2_Missense_Mutation_p.E79Q	NM_004751	NP_004742	O95395	GCNT3_HUMAN	glucosaminyl (N-acetyl) transferase 3, mucin	79	Lumenal (Potential).				protein O-linked glycosylation	Golgi membrane|integral to membrane|membrane fraction	beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity|N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity			ovary(1)|central_nervous_system(1)	2						AGGGGACCAAGAGGCAGTGCT	0.488			NA											7	242					0	0	0.001984	0	0
IGDCC4	57722	broad.mit.edu	37	15	65676690	65676690	+	Missense_Mutation	SNP	G	G	C			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr15:65676690G>C	uc002aou.1	-	20	3620	c.3410C>G	c.(3409-3411)TCT>TGT	p.S1137C	IGDCC4_uc002aot.1_Missense_Mutation_p.S725C	NM_020962	NP_066013	Q8TDY8	IGDC4_HUMAN	immunoglobulin superfamily, DCC subclass, member	1137	Cytoplasmic (Potential).					integral to membrane|plasma membrane				ovary(1)|pancreas(1)|skin(1)	3						ACTAAAGTCAGAGTGGACAAT	0.552			NA											3	142					0	0	0.004672	0	0
THSD4	79875	broad.mit.edu	37	15	72020963	72020963	+	Missense_Mutation	SNP	G	G	T			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr15:72020963G>T	uc002atb.1	+	8	1512	c.1433G>T	c.(1432-1434)GGA>GTA	p.G478V	THSD4_uc002atd.1_Missense_Mutation_p.G152V|THSD4_uc010ukg.1_Missense_Mutation_p.G118V|THSD4_uc002ate.2_Missense_Mutation_p.G118V	NM_024817	NP_079093	Q6ZMP0	THSD4_HUMAN	thrombospondin, type I, domain containing 4	478						proteinaceous extracellular matrix	metalloendopeptidase activity			ovary(2)	2						TACGAGGGCGGAGGGACCATG	0.507			NA											8	184					3.09899e-07	3.63951e-07	0.004482	1	0
MAN2C1	4123	broad.mit.edu	37	15	75654689	75654689	+	Missense_Mutation	SNP	C	C	G			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr15:75654689C>G	uc002baf.2	-	8	1020	c.1003G>C	c.(1003-1005)GAG>CAG	p.E335Q	MAN2C1_uc002bag.2_Missense_Mutation_p.E335Q|MAN2C1_uc002bah.2_Missense_Mutation_p.E335Q|MAN2C1_uc010bkk.2_Missense_Mutation_p.E236Q|MAN2C1_uc010umi.1_Missense_Mutation_p.E117Q|MAN2C1_uc010umj.1_RNA	NM_006715	NP_006706	Q9NTJ4	MA2C1_HUMAN	mannosidase, alpha, class 2C, member 1	335					mannose metabolic process		alpha-mannosidase activity|carbohydrate binding|protein binding|zinc ion binding				0						CTTACCATCTCCACCCAGGTG	0.617			NA											7	38					0	0	0.004482	0	0
IL16	3603	broad.mit.edu	37	15	81592196	81592196	+	Silent	SNP	C	C	T			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr15:81592196C>T	uc002bgh.3	+	14	2905	c.2529C>T	c.(2527-2529)ATC>ATT	p.I843I	IL16_uc010blq.1_Silent_p.I797I|IL16_uc002bge.3_RNA|IL16_uc010unp.1_Silent_p.I885I|IL16_uc002bgg.2_Silent_p.I843I|IL16_uc002bgi.1_Silent_p.I233I|IL16_uc002bgj.2_Silent_p.I337I|IL16_uc002bgk.2_Silent_p.I142I|IL16_uc002bgl.1_Silent_p.I142I|IL16_uc010unq.1_Silent_p.I142I	NM_172217	NP_757366	Q14005	IL16_HUMAN	interleukin 16 isoform 2	843					immune response|interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|extracellular space|nucleus|plasma membrane	cytokine activity			ovary(2)|lung(1)|skin(1)	4						GGCAGAGAATCAGCTCCTTTG	0.522			NA											5	56					0	0	0.000602	0	0
Unknown	0	broad.mit.edu	37	15	102292797	102292797	+	Missense_Mutation	SNP	C	C	G			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr15:102292797C>G	uc010usj.1	+	4	444	c.385C>G	c.(385-387)CCA>GCA	p.P129A	uc002bxo.2_RNA|uc002bxp.3_5'Flank|uc002bxt.2_5'Flank|uc002bxz.3_5'Flank|uc002byd.2_5'Flank|uc002bye.2_5'Flank|uc002byf.1_5'Flank|uc002byg.2_5'Flank|uc002byi.2_5'Flank|uc002byk.2_5'Flank|uc002bym.2_5'Flank|uc002byn.2_5'Flank|uc010usm.1_5'Flank					RecName: Full=Uncharacterized protein C15orf51.; Flags: Fragment;												NA						GAGCTGCTGTCCAACCTGCAC	0.597			NA											2	20					0	0	0.004672	0	0
ZNF597	146434	broad.mit.edu	37	16	3486852	3486852	+	Missense_Mutation	SNP	G	G	C			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr16:3486852G>C	uc002cvd.2	-	4	1031	c.847C>G	c.(847-849)CTT>GTT	p.L283V		NM_152457	NP_689670	Q96LX8	ZN597_HUMAN	zinc finger protein 597	283					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						GGCAAAGCAAGATTTGGTTTC	0.453			NA											4	231					0	0	0.009096	0	0
ACSM1	116285	broad.mit.edu	37	16	20638525	20638525	+	Silent	SNP	G	G	A			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr16:20638525G>A	uc002dhm.1	-	10	1481	c.1413C>T	c.(1411-1413)ATC>ATT	p.I471I	ACSM1_uc002dhn.1_Intron|ACSM1_uc010bwg.1_Silent_p.I471I	NM_052956	NP_443188	Q08AH1	ACSM1_HUMAN	acyl-CoA synthetase medium-chain family member	471					benzoate metabolic process|butyrate metabolic process|energy derivation by oxidation of organic compounds|fatty acid oxidation|xenobiotic metabolic process	mitochondrial matrix	acyl-CoA ligase activity|ATP binding|butyrate-CoA ligase activity|GTP binding|metal ion binding			central_nervous_system(1)|skin(1)	2						AGGCATTAATGATGTCATCAC	0.488			NA											9	416					0	0	0.004482	0	0
RBBP6	5930	broad.mit.edu	37	16	24581790	24581790	+	Missense_Mutation	SNP	G	G	T			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr16:24581790G>T	uc002dmh.2	+	17	4819	c.3779G>T	c.(3778-3780)GGA>GTA	p.G1260V	RBBP6_uc010vcb.1_Missense_Mutation_p.G1127V|RBBP6_uc002dmi.2_Missense_Mutation_p.G1226V|RBBP6_uc010bxr.2_Intron|RBBP6_uc002dmk.2_Missense_Mutation_p.G1093V	NM_006910	NP_008841	Q7Z6E9	RBBP6_HUMAN	retinoblastoma-binding protein 6 isoform 1	1260					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	chromosome|nucleolus|ubiquitin ligase complex	nucleic acid binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(3)|pancreas(1)	4				GBM - Glioblastoma multiforme(48;0.0518)		GGAACTGAAGGATCCAGCTCA	0.423			NA											24	39					6.32553e-13	7.6057e-13	0.004656	1	0
NLRC5	84166	broad.mit.edu	37	16	57085490	57085490	+	Silent	SNP	C	C	T			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr16:57085490C>T	uc002ekk.1	+	24	3688	c.3463C>T	c.(3463-3465)CTA>TTA	p.L1155L	NLRC5_uc002ekn.2_Silent_p.L874L|NLRC5_uc002ekl.2_Silent_p.L960L|NLRC5_uc002ekm.2_Silent_p.L930L|NLRC5_uc010ccr.1_RNA|NLRC5_uc010ccs.1_RNA|NLRC5_uc002eko.1_RNA|NLRC5_uc002ekp.1_Silent_p.L71L|NLRC5_uc002ekq.1_5'UTR|NLRC5_uc002ekr.1_Silent_p.L71L	NM_032206	NP_115582	Q86WI3	NLRC5_HUMAN	nucleotide-binding oligomerization domains 27	1155	LRR 11.				defense response to virus|innate immune response|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production|negative regulation of type I interferon-mediated signaling pathway|positive regulation of interferon-gamma-mediated signaling pathway|positive regulation of MHC class I biosynthetic process|positive regulation of transcription from RNA polymerase II promoter|positive regulation of type I interferon-mediated signaling pathway|regulation of kinase activity	cytosol|nucleus	ATP binding|protein binding|RNA polymerase II core promoter sequence-specific DNA binding			ovary(4)|skin(2)|breast(1)	7		all_neural(199;0.225)				CCTGGAGACTCTACTGGACTG	0.532			NA											14	711					0	0	0.007413	0	0
CNOT1	23019	broad.mit.edu	37	16	58619324	58619324	+	Missense_Mutation	SNP	C	C	G			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr16:58619324C>G	uc002env.2	-	8	1017	c.724G>C	c.(724-726)GAT>CAT	p.D242H	CNOT1_uc002enw.2_RNA|CNOT1_uc002enu.3_Missense_Mutation_p.D242H|CNOT1_uc002enx.2_Missense_Mutation_p.D242H|CNOT1_uc002enz.1_Intron	NM_016284	NP_057368	A5YKK6	CNOT1_HUMAN	CCR4-NOT transcription complex, subunit 1	242					nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol				ovary(4)|central_nervous_system(2)	6				Kidney(780;0.0722)|OV - Ovarian serous cystadenocarcinoma(108;0.173)|Epithelial(162;0.239)		CCTCCGGAATCAGGCAGGATC	0.468			NA											4	183					0	0	0.009096	0	0
CDH11	1009	broad.mit.edu	37	16	65038648	65038649	+	Missense_Mutation	DNP	CC	CC	AA			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr16:65038648_65038649CC>AA	uc002eoi.2	-	3	558_559	c.124_125GG>TT	c.(124-126)GGC>TTC	p.G42F	CDH11_uc010cdn.2_RNA|CDH11_uc002eoj.2_Missense_Mutation_p.G42F|CDH11_uc010vin.1_Intron|CDH11_uc010vio.1_Missense_Mutation_p.G42F	NM_001797	NP_001788	P55287	CAD11_HUMAN	cadherin 11, type 2 preproprotein	42					adherens junction organization|cell junction assembly|homophilic cell adhesion|ossification|skeletal system development	integral to membrane|plasma membrane	calcium ion binding|protein binding			lung(10)|ovary(3)|skin(1)	14		Ovarian(137;0.0973)		OV - Ovarian serous cystadenocarcinoma(108;0.205)		CCCCTCCTTGCCCTTCTCATGG	0.663			NA	T	USP6	aneurysmal bone cysts					TSP Lung(24;0.17)			8	18					0	0	0.004672	0	0
IRF8	3394	broad.mit.edu	37	16	85942710	85942710	+	Missense_Mutation	SNP	G	G	A	rs34712374		TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr16:85942710G>A	uc002fjh.2	+	3	346	c.289G>A	c.(289-291)GAC>AAC	p.D97N	IRF8_uc002fji.2_Missense_Mutation_p.D97N|IRF8_uc010chp.2_RNA	NM_002163	NP_002154	Q02556	IRF8_HUMAN	interferon regulatory factor 8	97	IRF tryptophan pentad repeat.				interferon-gamma-mediated signaling pathway|negative regulation of transcription from RNA polymerase II promoter|type I interferon-mediated signaling pathway	nucleus	DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity			breast(2)|ovary(1)	3		Prostate(104;0.0771)				GGAAGTGACGGACCGGTCCCA	0.453			NA											25	44					0	0	0.004656	0	0
FANCA	2175	broad.mit.edu	37	16	89862360	89862360	+	Missense_Mutation	SNP	G	G	C			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr16:89862360G>C	uc002fou.1	-	11	1002	c.960C>G	c.(958-960)TTC>TTG	p.F320L	FANCA_uc010vpn.1_Missense_Mutation_p.F320L	NM_000135	NP_000126	O15360	FANCA_HUMAN	Fanconi anemia, complementation group A isoform	320					DNA repair|protein complex assembly	cytoplasm|nucleoplasm	protein binding			ovary(2)|breast(2)|central_nervous_system(1)|skin(1)	6		Lung NSC(15;8.48e-06)|all_lung(18;1.31e-05)|all_hematologic(23;0.0194)		BRCA - Breast invasive adenocarcinoma(80;0.028)		GGGTATGACTGAAGAACCTCT	0.522			NA	D|Mis|N|F|S			AML|leukemia		Involved_in_tolerance_or_repair_of_DNA_crosslinks	FanconAnemia				3	91					0	0	0.004672	0	0
CENPBD1	92806	broad.mit.edu	37	16	90038109	90038109	+	Silent	SNP	C	C	G			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr16:90038109C>G	uc002fpr.2	-	1	834	c.222G>C	c.(220-222)CTG>CTC	p.L74L	AFG3L1_uc002fps.1_5'Flank|AFG3L1_uc002fpt.1_5'Flank|AFG3L1_uc002fpu.1_5'Flank|AFG3L1_uc002fpv.1_5'Flank|AFG3L1_uc002fpw.1_5'Flank|AFG3L1_uc002fpx.1_5'Flank	NM_145039	NP_659476	B2RD01	CENP1_HUMAN	CENPB DNA-binding domains containing 1	74					regulation of transcription, DNA-dependent	chromosome, centromeric region|nucleus	DNA binding				0						GAGAGGCTCTCAGAGGAGTAG	0.502			NA											4	19					0	0	0.009096	0	0
CAMTA2	23125	broad.mit.edu	37	17	4883116	4883116	+	Missense_Mutation	SNP	A	A	G			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr17:4883116A>G	uc002gah.1	-	9	1609	c.1501T>C	c.(1501-1503)TTC>CTC	p.F501L	CAMTA2_uc010cku.1_Missense_Mutation_p.F524L|CAMTA2_uc002gag.1_Missense_Mutation_p.F500L|CAMTA2_uc002gai.1_Missense_Mutation_p.F503L|CAMTA2_uc010ckv.1_Missense_Mutation_p.F148L|CAMTA2_uc010vsu.1_Missense_Mutation_p.F314L	NM_015099	NP_055914	O94983	CMTA2_HUMAN	calmodulin binding transcription activator 2	501					cardiac muscle hypertrophy in response to stress|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	calmodulin binding|chromatin binding|histone deacetylase binding|transcription factor binding			ovary(1)	1						GAAAGACTGAAGGGCTCCAGT	0.522			NA											5	251					0	0	0.000602	0	0
KIAA0753	9851	broad.mit.edu	37	17	6493842	6493842	+	Missense_Mutation	SNP	G	G	A			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr17:6493842G>A	uc002gde.3	-	17	2908	c.2549C>T	c.(2548-2550)CCC>CTC	p.P850L	KIAA0753_uc010vtd.1_Missense_Mutation_p.P306L|KIAA0753_uc010clo.2_Missense_Mutation_p.P551L|KIAA0753_uc010vte.1_Missense_Mutation_p.P551L	NM_014804	NP_055619	Q2KHM9	K0753_HUMAN	hypothetical protein LOC9851	850						centrosome					0				COAD - Colon adenocarcinoma(228;0.157)		GCCATTACAGGGCCTTTCTAA	0.403			NA											25	74					0	0	0.008361	0	0
MYH1	4619	broad.mit.edu	37	17	10399410	10399410	+	Missense_Mutation	SNP	C	C	A			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr17:10399410C>A	uc002gmo.2	-	35	5120	c.5026G>T	c.(5026-5028)GCT>TCT	p.A1676S	uc002gml.1_Intron	NM_005963	NP_005954	P12882	MYH1_HUMAN	myosin, heavy chain 1, skeletal muscle, adult	1676	Potential.					muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			ovary(10)|skin(6)|breast(3)|upper_aerodigestive_tract(1)|kidney(1)	21						TCCACCATAGCCAGCTGTTCC	0.572			NA											28	67					1.17739e-12	1.41147e-12	0.005443	1	0
MYOCD	93649	broad.mit.edu	37	17	12655756	12655756	+	Missense_Mutation	SNP	G	G	A			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr17:12655756G>A	uc002gnn.2	+	10	1450	c.1151G>A	c.(1150-1152)CGA>CAA	p.R384Q	MYOCD_uc002gno.2_Missense_Mutation_p.R384Q|MYOCD_uc002gnp.1_Missense_Mutation_p.R288Q|MYOCD_uc002gnq.2_Missense_Mutation_p.R103Q	NM_153604	NP_705832	Q8IZQ8	MYCD_HUMAN	myocardin isoform 2	384	SAP.				cardiac muscle cell differentiation|negative regulation of cell proliferation|negative regulation of cyclin-dependent protein kinase activity|positive regulation of smooth muscle cell differentiation|positive regulation of smooth muscle contraction|positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation|regulation of histone acetylation|smooth muscle cell differentiation	nucleus	nucleic acid binding|RNA polymerase II transcription factor binding transcription factor activity|transcription factor binding			central_nervous_system(2)|skin(2)|ovary(1)	5				UCEC - Uterine corpus endometrioid carcinoma (92;0.0969)		CAACAGCTTCGAATTCGGGGC	0.453			NA											12	64					0	0	0.00245	0	0
VTN	7448	broad.mit.edu	37	17	26696372	26696372	+	Missense_Mutation	SNP	C	C	T			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr17:26696372C>T	uc002hbc.2	-	4	756	c.607G>A	c.(607-609)GAG>AAG	p.E203K	SARM1_uc010wah.1_Intron|SEBOX_uc010crk.1_5'Flank|SARM1_uc010waj.1_Intron|SARM1_uc010crl.1_5'Flank	NM_000638	NP_000629	P04004	VTNC_HUMAN	vitronectin precursor	203	Hemopexin-like 1.				cell adhesion mediated by integrin|immune response|negative regulation of endopeptidase activity|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of protein binding|positive regulation of receptor-mediated endocytosis|positive regulation of smooth muscle cell migration|positive regulation of vascular endothelial growth factor receptor signaling pathway|smooth muscle cell-matrix adhesion	alphav-beta3 integrin-vitronectin complex|extracellular space	heparin binding|integrin binding|scavenger receptor activity			ovary(1)|kidney(1)	2	all_lung(13;0.000533)|Lung NSC(42;0.00171)			UCEC - Uterine corpus endometrioid carcinoma (53;0.153)	Urokinase(DB00013)	ATGGGGCCCTCGATGCCCCAG	0.587			NA											8	119					0	0	0.004482	0	0
FOXN1	8456	broad.mit.edu	37	17	26851622	26851622	+	Silent	SNP	C	C	G	rs138510671		TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr17:26851622C>G	uc010crm.2	+	3	423	c.225C>G	c.(223-225)CCC>CCG	p.P75P	FOXN1_uc002hbj.2_Silent_p.P75P	NM_003593	NP_003584	O15353	FOXN1_HUMAN	forkhead box N1	75					defense response|embryo development|epithelial cell proliferation|keratinocyte differentiation|organ morphogenesis|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|regulation of transcription from RNA polymerase II promoter|thymus development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			skin(1)	1	Lung NSC(42;0.00431)					CACCAGGGCCCGAGCAAGTCC	0.667			NA											10	62					0	0	0.010729	0	0
RAB11FIP4	84440	broad.mit.edu	37	17	29758831	29758831	+	Missense_Mutation	SNP	G	G	T			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr17:29758831G>T	uc002hgn.1	+	2	389	c.160G>T	c.(160-162)GTG>TTG	p.V54L		NM_032932	NP_116321	Q86YS3	RFIP4_HUMAN	RAB11 family interacting protein 4 (class II)	54	EF-hand.				cytokinesis|interspecies interaction between organisms|protein transport	cleavage furrow|endocytic vesicle|midbody|recycling endosome membrane	ADP-ribosylation factor binding|calcium ion binding|protein homodimerization activity|Rab GTPase binding			skin(1)	1		all_cancers(10;3.62e-13)|all_epithelial(10;0.000387)|all_lung(9;0.0132)|Breast(31;0.014)|all_hematologic(16;0.015)|Myeloproliferative disorder(56;0.0255)|Acute lymphoblastic leukemia(14;0.0259)|Ovarian(249;0.0423)|Lung NSC(157;0.066)				ATTCCCACAGGTGGAAAAACT	0.562			NA											21	51					3.83957e-06	4.43196e-06	0.00278	1	0
C17orf53	78995	broad.mit.edu	37	17	42225308	42225308	+	Missense_Mutation	SNP	C	C	G			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr17:42225308C>G	uc002ifi.1	+	3	322	c.137C>G	c.(136-138)TCT>TGT	p.S46C	C17orf53_uc010czq.1_Missense_Mutation_p.S46C|C17orf53_uc002ifj.1_Missense_Mutation_p.S46C|C17orf53_uc002ifk.1_RNA	NM_024032	NP_076937	Q8N3J3	CQ053_HUMAN	hypothetical protein LOC78995	46											0		Breast(137;0.0364)|Prostate(33;0.0376)		BRCA - Breast invasive adenocarcinoma(366;0.114)		AGACCTGTCTCTTCTAGGCCA	0.572			NA											4	106					0	0	0.000602	0	0
ANKFN1	162282	broad.mit.edu	37	17	54450167	54450167	+	Silent	SNP	C	C	T			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr17:54450167C>T	uc002iun.1	+	6	806	c.771C>T	c.(769-771)CTC>CTT	p.L257L		NM_153228	NP_694960	Q8N957	ANKF1_HUMAN	ankyrin-repeat and fibronectin type III domain	257										large_intestine(1)|ovary(1)	2						GGTATCGGCTCTACAGACGCA	0.483			NA											19	124					0	0	0.00278	0	0
APPBP2	10513	broad.mit.edu	37	17	58571968	58571968	+	Missense_Mutation	SNP	G	G	A			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr17:58571968G>A	uc002iys.1	-	3	526	c.238C>T	c.(238-240)CAT>TAT	p.H80Y	APPBP2_uc010ddl.1_Missense_Mutation_p.H9Y	NM_006380	NP_006371	Q92624	APBP2_HUMAN	amyloid beta precursor protein-binding protein	80	TPR 1.				intracellular protein transport	cytoplasmic vesicle membrane|microtubule|microtubule associated complex|nucleus	microtubule motor activity|protein binding				0	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		Epithelial(12;3.67e-13)|all cancers(12;1.44e-11)|Colorectal(3;0.01)			AAACAATGATGAAGCAAATGT	0.338			NA											4	111					0	0	0.009096	0	0
ACE	1636	broad.mit.edu	37	17	61574336	61574336	+	Silent	SNP	G	G	T			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr17:61574336G>T	uc002jau.1	+	24	3703	c.3681G>T	c.(3679-3681)ACG>ACT	p.T1227T	ACE_uc002jav.1_Silent_p.T653T|ACE_uc010ddv.1_Silent_p.T454T|ACE_uc010wpj.1_Silent_p.T612T|ACE_uc002jaw.1_RNA|ACE_uc010wpk.1_Silent_p.T432T	NM_000789	NP_000780	P12821	ACE_HUMAN	angiotensin I converting enzyme 1 isoform 1	1227	Extracellular (Potential).|Peptidase M2 2.				arachidonic acid secretion|hormone catabolic process|kidney development|peptide catabolic process|regulation of smooth muscle cell migration	endosome|external side of plasma membrane|extracellular space|integral to membrane|membrane fraction|plasma membrane	actin binding|bradykinin receptor binding|carboxypeptidase activity|chloride ion binding|drug binding|metallopeptidase activity|peptidyl-dipeptidase activity|zinc ion binding			ovary(2)|upper_aerodigestive_tract(1)|pancreas(1)	4					Benazepril(DB00542)|Captopril(DB01197)|Deserpidine(DB01089)|Enalapril(DB00584)|Fosinopril(DB00492)|Lisinopril(DB00722)|Moexipril(DB00691)|Perindopril(DB00790)|Quinapril(DB00881)|Ramipril(DB00178)|Rescinnamine(DB01180)|Spirapril(DB01348)|Trandolapril(DB00519)	ACAACTGGACGCCGAACTCCG	0.642			NA											5	6					7.48243e-07	8.73671e-07	0.006214	1	0
SMURF2	64750	broad.mit.edu	37	17	62568061	62568061	+	Missense_Mutation	SNP	T	T	C			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr17:62568061T>C	uc002jep.1	-	10	1259	c.871A>G	c.(871-873)ATC>GTC	p.I291V	SMURF2_uc002jeq.1_Missense_Mutation_p.I50V|SMURF2_uc002jer.1_Missense_Mutation_p.I50V	NM_022739	NP_073576	Q9HAU4	SMUF2_HUMAN	SMAD specific E3 ubiquitin protein ligase 2	291					BMP signaling pathway|negative regulation of transcription, DNA-dependent|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|regulation of transforming growth factor beta receptor signaling pathway|transforming growth factor beta receptor signaling pathway|ubiquitin-dependent SMAD protein catabolic process	cytosol|membrane raft|nucleus|plasma membrane|ubiquitin ligase complex	identical protein binding|SMAD binding|ubiquitin-protein ligase activity			skin(3)|lung(1)	4	Breast(5;1.32e-14)		BRCA - Breast invasive adenocarcinoma(8;9.88e-12)			TCACAATTGATGTTGCTAAGA	0.408			NA											20	52					0	0	0.012319	0	0
HELZ	9931	broad.mit.edu	37	17	65083055	65083055	+	Missense_Mutation	SNP	G	G	C			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr17:65083055G>C	uc010wqk.1	-	32	5574	c.5387C>G	c.(5386-5388)TCT>TGT	p.S1796C	HELZ_uc002jfv.3_RNA|HELZ_uc002jfx.3_Missense_Mutation_p.S1795C	NM_014877	NP_055692			helicase with zinc finger domain											ovary(1)|pancreas(1)	2	all_cancers(12;1.24e-11)|Breast(2;1.05e-17)|all_epithelial(3;3.87e-13)					AAAGTTGAAAGAAGATTGGTT	0.473			NA											10	156					0	0	0.006214	0	0
ARSG	22901	broad.mit.edu	37	17	66364735	66364735	+	Missense_Mutation	SNP	C	C	T			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr17:66364735C>T	uc002jhc.2	+	7	1547	c.751C>T	c.(751-753)CAC>TAC	p.H251Y	ARSG_uc002jhb.1_Missense_Mutation_p.H87Y	NM_014960	NP_055775	Q96EG1	ARSG_HUMAN	Arylsulfatase G precursor	251		Substrate (By similarity).			sulfur compound metabolic process	endoplasmic reticulum|extracellular space|lysosome	arylsulfatase activity|metal ion binding			ovary(1)	1			BRCA - Breast invasive adenocarcinoma(8;5.34e-07)|LUSC - Lung squamous cell carcinoma(166;0.24)			GGCCCACATGCACGTGCCCTT	0.602			NA											6	143					0	0	0.00308	0	0
UBE2O	63893	broad.mit.edu	37	17	74392500	74392500	+	Missense_Mutation	SNP	G	G	C			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr17:74392500G>C	uc002jrm.3	-	14	2583	c.2518C>G	c.(2518-2520)CCG>GCG	p.P840A	UBE2O_uc002jrn.3_Missense_Mutation_p.P840A|UBE2O_uc002jrl.3_Missense_Mutation_p.P444A	NM_022066	NP_071349	Q9C0C9	UBE2O_HUMAN	ubiquitin-conjugating enzyme E2O	840	Potential.						ATP binding|ubiquitin-protein ligase activity			breast(2)|skin(2)|lung(1)	5						TCCACAGTCGGAGAGGTGGGC	0.547			NA											4	178					0	0	0.001168	0	0
PCYT2	5833	broad.mit.edu	37	17	79867409	79867409	+	Silent	SNP	G	G	A			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr17:79867409G>A	uc002kcf.1	-	2	222	c.159C>T	c.(157-159)ATC>ATT	p.I53I	PCYT2_uc010wva.1_Silent_p.I21I|PCYT2_uc010wvb.1_Silent_p.I21I|PCYT2_uc002kce.1_5'UTR|PCYT2_uc002kcg.1_Silent_p.I64I|PCYT2_uc002kch.1_Silent_p.I53I|PCYT2_uc002kci.1_5'UTR|PCYT2_uc010dii.1_Silent_p.I53I|PCYT2_uc010wvc.1_5'UTR	NM_002861	NP_002852	Q99447	PCY2_HUMAN	phosphate cytidylyltransferase 2, ethanolamine	53	Catalytic 1 (Potential).				phospholipid biosynthetic process		ethanolamine-phosphate cytidylyltransferase activity				0	all_neural(118;0.0878)|Ovarian(332;0.12)		BRCA - Breast invasive adenocarcinoma(99;0.013)|OV - Ovarian serous cystadenocarcinoma(97;0.0382)			GCACGCCTACGATGAGGTAGT	0.632			NA											5	134					0	0	0.001984	0	0
GPS1	2873	broad.mit.edu	37	17	80014187	80014187	+	Missense_Mutation	SNP	G	G	A			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr17:80014187G>A	uc002kdl.1	+	9	1012	c.967G>A	c.(967-969)GAG>AAG	p.E323K	GPS1_uc002kdk.1_Missense_Mutation_p.E359K|GPS1_uc010dij.1_Missense_Mutation_p.E358K|GPS1_uc002kdm.1_Missense_Mutation_p.E303K|GPS1_uc002kdn.1_Missense_Mutation_p.E319K|GPS1_uc002kdo.1_Missense_Mutation_p.E322K|GPS1_uc010wvh.1_Missense_Mutation_p.E315K	NM_004127	NP_004118	Q13098	CSN1_HUMAN	G protein pathway suppressor 1 isoform 2	323					cell cycle|cullin deneddylation|inactivation of MAPK activity|JNK cascade	cytoplasm|signalosome	GTPase inhibitor activity|protein binding			central_nervous_system(1)	1	all_neural(118;0.0878)|Ovarian(332;0.227)|all_lung(278;0.246)		BRCA - Breast invasive adenocarcinoma(99;0.0114)|OV - Ovarian serous cystadenocarcinoma(97;0.0211)			CTTGGAGCTGGAGCCACAGGT	0.582			NA											35	189					0	0	0.013114	0	0
FOXK2	3607	broad.mit.edu	37	17	80542037	80542037	+	Missense_Mutation	SNP	G	G	A			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr17:80542037G>A	uc002kfn.2	+	6	1423	c.1252G>A	c.(1252-1254)GAA>AAA	p.E418K	FOXK2_uc002kfm.1_Missense_Mutation_p.E418K|FOXK2_uc010diu.2_Intron	NM_004514	NP_004505	Q01167	FOXK2_HUMAN	forkhead box K2	418					embryo development|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|regulation of transcription from RNA polymerase II promoter|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|magnesium ion binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding				0	Breast(20;0.00106)|all_neural(118;0.0952)		OV - Ovarian serous cystadenocarcinoma(97;0.0371)|BRCA - Breast invasive adenocarcinoma(99;0.0415)			TGTCATCCAGGAAGCCCGGTT	0.682			NA											3	22					0	0	0.004672	0	0
DLGAP1	9229	broad.mit.edu	37	18	3729134	3729134	+	Splice_Site	SNP	C	C	A			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr18:3729134C>A	uc002kmf.2	-	4	1658	c.1591_splice	c.e4+1	p.V531_splice	DLGAP1_uc010wyz.1_Splice_Site_p.V531_splice|DLGAP1_uc002kme.1_Splice_Site_p.V229_splice|DLGAP1_uc010dkn.2_Splice_Site_p.G229_splice|DLGAP1_uc010wyw.1_Splice_Site_p.V237_splice|DLGAP1_uc010wyx.1_Splice_Site_p.G243_splice|DLGAP1_uc010wyy.1_Splice_Site_p.A243_splice|DLGAP1_uc002kmg.2_Splice_Site_p.V229_splice|DLGAP1_uc002kmk.2_Splice_Site_p.G531_splice	NM_004746	NP_004737	O14490	DLGP1_HUMAN	discs large homolog-associated protein 1 isoform						synaptic transmission	cell junction|postsynaptic density|postsynaptic membrane				ovary(2)|pancreas(1)|skin(1)	4		Colorectal(8;0.0257)				CGCGCACTCACCCGTGCTGCT	0.637			NA											17	15					3.41278e-10	4.0433e-10	0.00499	1	0
ARHGAP28	79822	broad.mit.edu	37	18	6889985	6889985	+	Silent	SNP	C	C	T			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr18:6889985C>T	uc010wzi.1	+	12	1342	c.1104C>T	c.(1102-1104)TTC>TTT	p.F368F	ARHGAP28_uc002knc.2_Silent_p.F493F|ARHGAP28_uc002knd.2_Silent_p.F386F|ARHGAP28_uc002kne.2_Silent_p.F386F|ARHGAP28_uc002knf.2_Silent_p.F377F			B4DXL2	B4DXL2_HUMAN	SubName: Full=Putative uncharacterized protein ARHGAP28;	368					signal transduction	intracellular				pancreas(1)	1		Colorectal(10;0.168)				ACCTTTTCTTCAGTAGAAGCA	0.408			NA											7	157					0	0	0.00308	0	0
ARHGAP28	79822	broad.mit.edu	37	18	6890048	6890048	+	Silent	SNP	C	C	T			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr18:6890048C>T	uc010wzi.1	+	12	1405	c.1167C>T	c.(1165-1167)ATC>ATT	p.I389I	ARHGAP28_uc002knc.2_Silent_p.I514I|ARHGAP28_uc002knd.2_Silent_p.I407I|ARHGAP28_uc002kne.2_Silent_p.I407I|ARHGAP28_uc002knf.2_Silent_p.I398I			B4DXL2	B4DXL2_HUMAN	SubName: Full=Putative uncharacterized protein ARHGAP28;	389					signal transduction	intracellular				pancreas(1)	1		Colorectal(10;0.168)				CCCACATCATCCGCCTAATGC	0.448			NA											6	152					0	0	0.001984	0	0
ZNF271	10778	broad.mit.edu	37	18	32887308	32887308	+	Silent	SNP	C	C	T			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr18:32887308C>T	uc002kyq.3	+	3	1712	c.720C>T	c.(718-720)ATC>ATT	p.I240I	ZNF271_uc002kyp.3_Silent_p.I240I|ZNF271_uc002kyr.3_Silent_p.I240I	NR_024565				SubName: Full=cDNA FLJ13394 fis, clone PLACE1001304, highly similar to Homo sapiens zinc finger protein 271 (ZNF271), mRNA;												0						TATTCTTCATCAGAGAATTCA	0.408			NA											6	109					0	0	0.001984	0	0
SERPINB4	6318	broad.mit.edu	37	18	61328318	61328318	+	Missense_Mutation	SNP	C	C	T			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr18:61328318C>T	uc002ljg.2	-	1	159	c.133G>A	c.(133-135)GCC>ACC	p.A45T	SERPINB3_uc002lji.2_Missense_Mutation_p.A45T|SERPINB3_uc010dqa.2_Missense_Mutation_p.A45T|SERPINB3_uc010dqb.2_Missense_Mutation_p.A45T|SERPINB3_uc010dqc.2_Missense_Mutation_p.A45T			P48594	SPB4_HUMAN	SubName: Full=Squamous cell carcinoma antigen 2;	45					immune response|regulation of proteolysis	cytoplasm|extracellular region	protein binding|serine-type endopeptidase inhibitor activity			ovary(2)|lung(1)	3						TTGTCTTTGGCTCCTAAGAGG	0.438			NA											5	166					0	0	0.000602	0	0
SERPINB10	5273	broad.mit.edu	37	18	61602377	61602378	+	Missense_Mutation	DNP	CC	CC	TT			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr18:61602377_61602378CC>TT	uc010xev.1	+	8	1185_1186	c.1095_1096CC>TT	c.(1093-1098)GTCCCA>GTTTCA	p.P366S	SERPINB10_uc010xew.1_Missense_Mutation_p.P366S	NM_005024	NP_005015	P48595	SPB10_HUMAN	serine (or cysteine) proteinase inhibitor, clade	366						cytoplasm|nucleus	serine-type endopeptidase inhibitor activity			lung(1)|kidney(1)|skin(1)	3		Esophageal squamous(42;0.131)				GAATTAGAGTCCCATCCATTGA	0.386			NA											5	181					0	0	0.004672	0	0
MIER2	54531	broad.mit.edu	37	19	326574	326574	+	Missense_Mutation	SNP	C	C	G			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr19:326574C>G	uc002lok.1	-	6	527	c.518G>C	c.(517-519)AGA>ACA	p.R173T		NM_017550	NP_060020	Q8N344	MIER2_HUMAN	mesoderm induction early response 1, family	173					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding				0		all_cancers(10;1.05e-30)|all_epithelial(18;3.04e-19)|Acute lymphoblastic leukemia(61;4.36e-14)|all_hematologic(61;4.84e-09)|Lung NSC(49;2.49e-05)|all_lung(49;4.36e-05)|Breast(49;0.000304)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GCCAGGCTCTCTGTCTTCATC	0.562			NA											6	95					0	0	0.001168	0	0
STK11	6794	broad.mit.edu	37	19	1220449	1220449	+	Missense_Mutation	SNP	A	A	T			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr19:1220449A>T	uc002lrl.1	+	4	1657	c.542A>T	c.(541-543)AAC>ATC	p.N181I		NM_000455	NP_000446	Q15831	STK11_HUMAN	serine/threonine protein kinase 11	181	Protein kinase.		N -> E (in sporadic cancer; somatic mutation; impairs heterotrimeric complex assembly with STRADA and CAB39; requires 2 nucleotide substitutions).		anoikis|cell cycle arrest|energy reserve metabolic process|insulin receptor signaling pathway|positive regulation of transforming growth factor beta receptor signaling pathway|regulation of fatty acid biosynthetic process|regulation of fatty acid oxidation	cytosol|nucleus	ATP binding|magnesium ion binding|protein serine/threonine kinase activity	p.0?(19)|p.Y156fs*87(4)|p.?(4)		lung(174)|cervix(35)|skin(15)|large_intestine(12)|pancreas(6)|gastrointestinal_tract_(site_indeterminate)(5)|stomach(4)|ovary(4)|breast(2)|upper_aerodigestive_tract(1)|testis(1)|liver(1)|biliary_tract(1)|small_intestine(1)|urinary_tract(1)|oesophagus(1)|prostate(1)|kidney(1)	266		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;7.93e-06)|all_lung(49;1.25e-05)|Breast(49;0.000172)|Renal(1328;0.0183)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|Lung(535;0.00942)|STAD - Stomach adenocarcinoma(1328;0.18)		AAGCCGGGGAACCTGCTGCTC	0.662			14	D|Mis|N|F|S		NSCLC|pancreatic	jejunal harmartoma|ovarian|testicular|pancreatic			Peutz-Jeghers_syndrome	TSP Lung(3;<1E-08)			3	4					0	0	0.004672	0	0
TCF3	6929	broad.mit.edu	37	19	1619133	1619133	+	Missense_Mutation	SNP	G	G	C			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr19:1619133G>C	uc002ltr.2	-	16	1494	c.1427C>G	c.(1426-1428)TCT>TGT	p.S476C	TCF3_uc002lto.2_Missense_Mutation_p.S237C|TCF3_uc002ltt.3_Missense_Mutation_p.S476C|TCF3_uc002ltq.2_Missense_Mutation_p.S425C|TCF3_uc002lts.1_Missense_Mutation_p.S392C|TCF3_uc010dso.1_RNA	NM_003200	NP_003191	P15923	TFE2_HUMAN	transcription factor 3 isoform E12	476					B cell lineage commitment|B cell lineage commitment|G1 phase of mitotic cell cycle|immunoglobulin V(D)J recombination|muscle cell differentiation|positive regulation of B cell proliferation|positive regulation of cell cycle|positive regulation of muscle cell differentiation|positive regulation of neuron differentiation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus|protein complex|transcription factor complex	bHLH transcription factor binding|DNA binding|E-box binding|identical protein binding|mitogen-activated protein kinase kinase kinase binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|vitamin D response element binding			lung(2)|breast(2)|ovary(1)|large_intestine(1)|skin(1)	7		Acute lymphoblastic leukemia(61;5.94e-12)|all_hematologic(61;1.27e-07)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GGGAGGCCGAGACAGGTCAGG	0.657			NA	T	PBX1|HLF|TFPT	pre B-ALL								6	64					0	0	0.001984	0	0
DOT1L	84444	broad.mit.edu	37	19	2222272	2222272	+	Nonsense_Mutation	SNP	C	C	G			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr19:2222272C>G	uc002lvb.3	+	24	3140	c.3104C>G	c.(3103-3105)TCA>TGA	p.S1035*	DOT1L_uc002lvc.1_Nonsense_Mutation_p.S329*|DOT1L_uc002lve.1_3'UTR	NM_032482	NP_115871	Q8TEK3	DOT1L_HUMAN	DOT1-like, histone H3 methyltransferase	1035						nucleus	DNA binding|histone-lysine N-methyltransferase activity|protein binding			pancreas(2)|upper_aerodigestive_tract(1)|lung(1)	4		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TCCGGCTTCTCAGATCCTGAG	0.667			NA											3	45					0	0	0.009096	0	0
CREB3L3	84699	broad.mit.edu	37	19	4171672	4171672	+	Silent	SNP	C	C	T			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr19:4171672C>T	uc002lzl.2	+	10	1208	c.1092C>T	c.(1090-1092)CAC>CAT	p.H364H	CREB3L3_uc002lzm.2_Silent_p.H354H|CREB3L3_uc010xib.1_Silent_p.H353H|CREB3L3_uc010xic.1_Nonsense_Mutation_p.Q320*	NM_032607	NP_115996	Q68CJ9	CR3L3_HUMAN	cAMP responsive element binding protein 3-like	364	Lumenal (Potential).	Cleavage; by PS1 (By similarity).			response to unfolded protein	endoplasmic reticulum membrane|integral to membrane|nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|skin(1)	2				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0232)|STAD - Stomach adenocarcinoma(1328;0.18)		GAACTTTGCACAACGATGCTG	0.642			NA											24	158					0	0	0.008361	0	0
INSR	3643	broad.mit.edu	37	19	7125477	7125477	+	Silent	SNP	G	G	T			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr19:7125477G>T	uc002mgd.1	-	17	3184	c.3075C>A	c.(3073-3075)CTC>CTA	p.L1025L	INSR_uc002mge.1_Silent_p.L1013L	NM_000208	NP_000199	P06213	INSR_HUMAN	insulin receptor isoform Long precursor	1025	Protein kinase.|Cytoplasmic (Potential).				activation of MAPK activity|activation of protein kinase B activity|carbohydrate metabolic process|fibroblast growth factor receptor signaling pathway|G-protein coupled receptor protein signaling pathway|glucose homeostasis|heart morphogenesis|peptidyl-tyrosine phosphorylation|positive regulation of cell migration|positive regulation of cell proliferation|positive regulation of developmental growth|positive regulation of DNA replication|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of glycolysis|positive regulation of MAPKKK cascade|positive regulation of mitosis|positive regulation of nitric oxide biosynthetic process|positive regulation of protein kinase B signaling cascade|positive regulation of protein phosphorylation|positive regulation of respiratory burst|protein autophosphorylation|protein heterotetramerization|regulation of embryonic development|regulation of transcription, DNA-dependent|transformation of host cell by virus	caveola|endosome membrane|insulin receptor complex|microsome	ATP binding|GTP binding|insulin binding|insulin receptor activity|insulin receptor substrate binding|insulin-like growth factor I binding|insulin-like growth factor II binding|insulin-like growth factor receptor binding|metal ion binding|phosphatidylinositol 3-kinase binding|PTB domain binding|receptor signaling protein tyrosine kinase activity|SH2 domain binding			ovary(4)|lung(3)|central_nervous_system(2)|large_intestine(1)|stomach(1)|skin(1)	12					Insulin Glargine recombinant(DB00047)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	GCTCTCGAAGGAGGGTGATCT	0.572			NA											8	69					7.48243e-07	8.73671e-07	0.006214	1	0
RDH8	50700	broad.mit.edu	37	19	10132255	10132255	+	Nonsense_Mutation	SNP	C	C	T			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr19:10132255C>T	uc002mmr.2	+	6	1015	c.766C>T	c.(766-768)CAG>TAG	p.Q256*		NM_015725	NP_056540	Q9NYR8	RDH8_HUMAN	retinol dehydrogenase 8 (all-trans)	256					estrogen biosynthetic process|response to stimulus|visual perception	cytoplasm|integral to plasma membrane	binding|estradiol 17-beta-dehydrogenase activity|NADP-retinol dehydrogenase activity|retinol dehydrogenase activity			ovary(3)|pancreas(1)	4			Epithelial(33;4.24e-05)		Vitamin A(DB00162)	CCTGCGCCGACAGACCAACAT	0.637			NA											12	14					0	0	0.004007	0	0
KEAP1	9817	broad.mit.edu	37	19	10602581	10602581	+	Missense_Mutation	SNP	C	C	T			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr19:10602581C>T	uc002moq.1	-	3	1153	c.997G>A	c.(997-999)GGC>AGC	p.G333S	KEAP1_uc002mop.1_Missense_Mutation_p.G51S|KEAP1_uc002mor.1_Missense_Mutation_p.G333S	NM_012289	NP_036421	Q14145	KEAP1_HUMAN	kelch-like ECH-associated protein 1	333	Kelch 1.		G -> C (in a NSCLC cell line; strongly reduces interaction with NFE2L2 and reduces repression of NFE2L2-dependent gene expression).		regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|midbody|nucleus	protein binding			lung(12)|breast(3)|ovary(1)|pancreas(1)	17			OV - Ovarian serous cystadenocarcinoma(20;2.71e-09)|Epithelial(33;2.32e-06)|all cancers(31;1.42e-05)			CGGAAGTAGCCGCCCGCGGTG	0.677			NA											15	11					0	0	0.006122	0	0
PRKCSH	5589	broad.mit.edu	37	19	11560101	11560101	+	Silent	SNP	A	A	G			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr19:11560101A>G	uc002mrt.2	+	17	1797	c.1461A>G	c.(1459-1461)AAA>AAG	p.K487K	PRKCSH_uc002mru.2_Silent_p.K484K|PRKCSH_uc010xlz.1_Silent_p.K494K|PRKCSH_uc010dya.2_Silent_p.K269K|PRKCSH_uc010dyb.2_Silent_p.K484K	NM_002743	NP_002734	P14314	GLU2B_HUMAN	protein kinase C substrate 80K-H isoform 1	487					innate immune response|intracellular protein kinase cascade|post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum lumen	calcium ion binding|protein kinase C binding				0						TGTGCGGGAAAGAGACCATGG	0.692			NA											18	85					0	0	0.008871	0	0
ZNF878	729747	broad.mit.edu	37	19	12157506	12157506	+	Nonsense_Mutation	SNP	G	G	A			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr19:12157506G>A	uc002mta.1	-	3	214	c.214C>T	c.(214-216)CAG>TAG	p.Q72*		NM_001080404	NP_001073873	C9JN71	ZN878_HUMAN	zinc finger protein 878	25	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding				0						AGATTTTTCTGGGAAGGATCC	0.478			NA											27	145					0	0	0.003954	0	0
LOC284441	284441	broad.mit.edu	37	19	20369582	20369582	+	Missense_Mutation	SNP	G	G	C			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr19:20369582G>C	uc002nov.2	+	1	1126	c.375G>C	c.(373-375)AGG>AGC	p.R125S		NR_003128				SubName: Full=cDNA FLJ51655, highly similar to Actin-like protein 2;												0						ATCTTACCAGGAGACTGGATA	0.443			NA											3	147					0	0	0.004672	0	0
ZNF91	7644	broad.mit.edu	37	19	23542873	23542873	+	Missense_Mutation	SNP	C	C	G	rs1816638		TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr19:23542873C>G	uc002nre.2	-	4	3021	c.2908G>C	c.(2908-2910)GAA>CAA	p.E970Q	ZNF91_uc002nrd.2_5'Flank|ZNF91_uc010xrj.1_Missense_Mutation_p.E938Q	NM_003430	NP_003421	Q05481	ZNF91_HUMAN	zinc finger protein 91	970	C2H2-type 30.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		all_lung(12;0.0349)|Lung NSC(12;0.0538)|all_epithelial(12;0.0611)				TTGCCACATTCTTCACATTTG	0.368			NA											5	138					0	0	0.001168	0	0
ZNF781	163115	broad.mit.edu	37	19	38160502	38160502	+	Missense_Mutation	SNP	A	A	C			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr19:38160502A>C	uc002ogy.2	-	4	1290	c.548T>G	c.(547-549)ATA>AGA	p.I183R	ZNF781_uc002ogz.2_Missense_Mutation_p.I178R	NM_152605	NP_689818	Q8N8C0	ZN781_HUMAN	zinc finger protein 781	183					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						TTGAGCAATTATTGAATGCTT	0.378			NA											22	103					0	0	0.00278	0	0
PSG5	5673	broad.mit.edu	37	19	43680050	43680050	+	Silent	SNP	G	G	C			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr19:43680050G>C	uc002ovu.2	-	3	812	c.681C>G	c.(679-681)CGC>CGG	p.R227R	PSG6_uc010xwk.1_Intron|PSG5_uc010eir.2_Intron|PSG5_uc002ovx.2_Silent_p.R227R|PSG5_uc002ovv.2_Silent_p.R320R|PSG5_uc002ovw.2_Intron	NM_002781	NP_002772	Q15238	PSG5_HUMAN	pregnancy specific beta-1-glycoprotein 5	227	Ig-like C2-type 1.				female pregnancy	extracellular region				skin(3)	3		Prostate(69;0.00899)				CTGGGTCACTGCGCATGCCAC	0.493			NA											79	148					0	0	0.01441	0	0
EML2	24139	broad.mit.edu	37	19	46124837	46124837	+	Silent	SNP	G	G	A			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr19:46124837G>A	uc002pcn.2	-	10	935	c.900C>T	c.(898-900)CTC>CTT	p.L300L	EML2_uc002pco.2_RNA|EML2_uc002pcp.2_Silent_p.L184L|EML2_uc010xxl.1_Silent_p.L447L|EML2_uc010xxm.1_Silent_p.L501L|EML2_uc010xxn.1_RNA|EML2_uc010xxo.1_Silent_p.L300L|EML2_uc010ekj.2_Missense_Mutation_p.S267F	NM_012155	NP_036287	O95834	EMAL2_HUMAN	echinoderm microtubule associated protein like	300	WD 5.				sensory perception of sound|visual perception	cytoplasm|intracellular membrane-bounded organelle|microtubule|microtubule associated complex	catalytic activity|protein binding			large_intestine(1)|ovary(1)	2		Ovarian(192;0.179)|all_neural(266;0.224)		OV - Ovarian serous cystadenocarcinoma(262;0.00553)|GBM - Glioblastoma multiforme(486;0.131)|Epithelial(262;0.197)		GCAGGGCGCAGAGCCCAAACA	0.682			NA											22	27					0	0	0.003954	0	0
GRLF1	2909	broad.mit.edu	37	19	47422425	47422425	+	Missense_Mutation	SNP	G	G	A			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr19:47422425G>A	uc010ekv.2	+	1	493	c.493G>A	c.(493-495)GAT>AAT	p.D165N		NM_004491	NP_004482	Q9NRY4	RHG35_HUMAN	glucocorticoid receptor DNA binding factor 1	165					axon guidance|negative regulation of transcription, DNA-dependent|small GTPase mediated signal transduction|transcription, DNA-dependent	cytosol	DNA binding|Rho GTPase activator activity|transcription corepressor activity			central_nervous_system(1)	1		all_cancers(25;1.51e-09)|all_epithelial(76;1.87e-07)|all_lung(116;7.86e-06)|Lung NSC(112;2.31e-05)|Ovarian(192;0.0129)|all_neural(266;0.026)|Breast(70;0.077)		all cancers(93;2.03e-05)|OV - Ovarian serous cystadenocarcinoma(262;2.57e-05)|Epithelial(262;0.00135)|GBM - Glioblastoma multiforme(486;0.0289)		TCTTGGTATTGATGTTAGCAG	0.453			NA											4	54					0	0	0.009096	0	0
GRIN2D	2906	broad.mit.edu	37	19	48908350	48908350	+	Silent	SNP	G	G	A			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr19:48908350G>A	uc002pjc.3	+	3	913	c.825G>A	c.(823-825)GTG>GTA	p.V275V		NM_000836	NP_000827	O15399	NMDE4_HUMAN	N-methyl-D-aspartate receptor subunit 2D	275	Extracellular (Potential).					cell junction|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|protein binding			ovary(3)|breast(3)	6		all_epithelial(76;1.11e-06)|all_lung(116;5.79e-06)|Lung NSC(112;1.18e-05)|all_neural(266;0.0189)|Ovarian(192;0.0261)|Breast(70;0.203)		all cancers(93;0.00014)|OV - Ovarian serous cystadenocarcinoma(262;0.000233)|Epithelial(262;0.0112)|GBM - Glioblastoma multiforme(486;0.0161)	L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Orphenadrine(DB01173)	GGTTCATGGTGGGGCCCCAGC	0.706			NA											4	15					0	0	0.009096	0	0
SIGLEC9	27180	broad.mit.edu	37	19	51629008	51629008	+	Silent	SNP	C	C	T			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr19:51629008C>T	uc002pvu.2	+	2	643	c.576C>T	c.(574-576)ACC>ACT	p.T192T	SIGLEC9_uc010yct.1_Silent_p.T192T	NM_014441	NP_055256	Q9Y336	SIGL9_HUMAN	sialic acid binding Ig-like lectin 9 precursor	192	Extracellular (Potential).|Ig-like C2-type 1.				cell adhesion|cell surface receptor linked signaling pathway	integral to plasma membrane	sugar binding			skin(1)	1		all_neural(266;0.0529)		GBM - Glioblastoma multiforme(134;0.000826)|OV - Ovarian serous cystadenocarcinoma(262;0.00295)		ACCCCTCCACCACCCGCTCCT	0.657			NA											47	55					0	0	0.01441	0	0
BIRC8	112401	broad.mit.edu	37	19	53793072	53793072	+	Missense_Mutation	SNP	C	C	T			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr19:53793072C>T	uc002qbk.2	-	1	1804	c.556G>A	c.(556-558)GAG>AAG	p.E186K		NM_033341	NP_203127	Q96P09	BIRC8_HUMAN	baculoviral IAP repeat-containing 8	186					apoptosis		zinc ion binding			lung(1)	1				GBM - Glioblastoma multiforme(134;0.00304)		CAAAGCTTCTCCTCTTGCAGA	0.433			NA											10	111					0	0	0.006214	0	0
ZNF256	10172	broad.mit.edu	37	19	58455413	58455413	+	Missense_Mutation	SNP	C	C	G			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr19:58455413C>G	uc002qqu.2	-	2	284	c.49G>C	c.(49-51)GAG>CAG	p.E17Q	ZNF256_uc010euj.2_Intron	NM_005773	NP_005764	Q9Y2P7	ZN256_HUMAN	zinc finger protein 256	17	KRAB.				multicellular organismal development|negative regulation of transcription, DNA-dependent	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			upper_aerodigestive_tract(1)|skin(1)	2		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0155)		GCCACGTCCTCAAAGGTCACA	0.507	NSCLC(55;1313 1552 8040 11996)		NA											4	59					0	0	0.009096	0	0
CYP1B1	1545	broad.mit.edu	37	2	38301556	38301556	+	Missense_Mutation	SNP	C	C	T			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr2:38301556C>T	uc002rqo.2	-	3	1379	c.976G>A	c.(976-978)GAC>AAC	p.D326N		NM_000104	NP_000095	Q16678	CP1B1_HUMAN	cytochrome P450, family 1, subfamily B,	326					visual perception|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding|protein binding			ovary(1)|central_nervous_system(1)	2		all_hematologic(82;0.21)			Estrone(DB00655)	CCGAAGATGTCAGTGATAGTG	0.632			NA											5	12					0	0	0.00308	0	0
SLC8A1	6546	broad.mit.edu	37	2	40656137	40656137	+	Silent	SNP	G	G	T			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr2:40656137G>T	uc002rrx.2	-	1	1308	c.1284C>A	c.(1282-1284)ACC>ACA	p.T428T	SLC8A1_uc002rry.2_Silent_p.T428T|SLC8A1_uc002rrz.2_Silent_p.T428T|SLC8A1_uc002rsa.2_Silent_p.T428T|SLC8A1_uc002rsd.3_Silent_p.T428T|SLC8A1_uc002rsb.1_Silent_p.T428T|SLC8A1_uc010fan.1_Silent_p.T428T|SLC8A1_uc002rsc.1_Silent_p.T428T	NM_021097	NP_066920	P32418	NAC1_HUMAN	solute carrier family 8 (sodium/calcium	428	Calx-beta 1.|Cytoplasmic (Potential).				cell communication|muscle contraction|platelet activation	integral to plasma membrane	calcium:sodium antiporter activity|calmodulin binding|heat shock protein binding			ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	4					Alpha-Linolenic Acid(DB00132)|Icosapent(DB00159)	TGCGGATAATGGTAAGGGCCA	0.433			NA											5	91					3.59834e-05	4.14167e-05	0.001168	1	0
PAPOLG	64895	broad.mit.edu	37	2	61009128	61009128	+	Missense_Mutation	SNP	G	G	A			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr2:61009128G>A	uc002sai.2	+	11	1246	c.1015G>A	c.(1015-1017)GAA>AAA	p.E339K	PAPOLG_uc002saj.2_Missense_Mutation_p.E28K|PAPOLG_uc002sak.2_5'UTR|PAPOLG_uc010fch.2_Missense_Mutation_p.E28K	NM_022894	NP_075045	Q9BWT3	PAPOG_HUMAN	poly(A) polymerase gamma	339					mRNA processing|RNA polyadenylation|transcription, DNA-dependent	nucleus	ATP binding|metal ion binding|polynucleotide adenylyltransferase activity|RNA binding			ovary(1)|central_nervous_system(1)	2	all_hematologic(2;0.0797)		LUSC - Lung squamous cell carcinoma(5;1.19e-07)|Lung(5;2.86e-06)|Epithelial(17;0.0768)			AATGGTAGAAGAATTTAAACA	0.403	GBM(183;1497 2932 21839 46797)		NA											4	133					0	0	0.009096	0	0
KIAA1841	84542	broad.mit.edu	37	2	61298824	61298824	+	Missense_Mutation	SNP	G	G	C			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr2:61298824G>C	uc002saw.3	+	4	537	c.234G>C	c.(232-234)GAG>GAC	p.E78D	KIAA1841_uc002sax.3_5'UTR|KIAA1841_uc002say.2_Missense_Mutation_p.E78D|KIAA1841_uc002sav.3_Missense_Mutation_p.E78D	NM_001129993	NP_001123465	Q6NSI8	K1841_HUMAN	KIAA1841 protein isoform a	78											0			Epithelial(17;0.193)			CTGCTGGAGAGAGTCCTGTTG	0.393			NA											3	129					0	0	0.009096	0	0
EXOC6B	23233	broad.mit.edu	37	2	72945355	72945355	+	Silent	SNP	C	C	T			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr2:72945355C>T	uc010fep.2	-	6	684	c.546G>A	c.(544-546)GTG>GTA	p.V182V	EXOC6B_uc002sij.2_Silent_p.V182V	NM_015189	NP_056004	Q9Y2D4	EXC6B_HUMAN	SEC15-like 2	182					protein transport|vesicle docking involved in exocytosis	exocyst				central_nervous_system(2)	2						TGTCCACCATCACCTTGCAGA	0.423			NA											19	106					0	0	0.008871	0	0
ZNF514	84874	broad.mit.edu	37	2	95815686	95815686	+	Missense_Mutation	SNP	C	C	T			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr2:95815686C>T	uc002sue.1	-	5	918	c.544G>A	c.(544-546)GAT>AAT	p.D182N	ZNF514_uc002sud.1_Missense_Mutation_p.D255N	NM_032788	NP_116177	Q96K75	ZN514_HUMAN	zinc finger protein 514	182					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						AATTCTGTATCACATTTATAA	0.393			NA											32	258					0	0	0.012213	0	0
KIAA1310	55683	broad.mit.edu	37	2	97275266	97275266	+	Missense_Mutation	SNP	C	C	G			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr2:97275266C>G	uc002swn.3	-	12	1499	c.1353G>C	c.(1351-1353)TTG>TTC	p.L451F	KIAA1310_uc002swh.3_Missense_Mutation_p.L339F|KIAA1310_uc002swi.3_Missense_Mutation_p.L352F|KIAA1310_uc002swj.3_RNA|KIAA1310_uc002swk.3_Missense_Mutation_p.L364F|KIAA1310_uc010fhz.2_Missense_Mutation_p.L245F|KIAA1310_uc002swl.3_Missense_Mutation_p.L352F|KIAA1310_uc002swm.3_RNA|KIAA1310_uc010yur.1_Missense_Mutation_p.L245F|KIAA1310_uc002swp.1_Missense_Mutation_p.L352F|KIAA1310_uc002swq.1_Missense_Mutation_p.L223F|KIAA1310_uc010fhy.1_Missense_Mutation_p.L352F	NM_001115016	NP_001108488	Q9P2N6	K1310_HUMAN	hypothetical protein LOC55683 isoform a	451											0						TGCTCTGAGTCAACCCTTCTG	0.383			NA											5	435					0	0	0.001984	0	0
EIF5B	9669	broad.mit.edu	37	2	99978250	99978250	+	Missense_Mutation	SNP	G	G	A			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr2:99978250G>A	uc002tab.2	+	4	1070	c.886G>A	c.(886-888)GAA>AAA	p.E296K		NM_015904	NP_056988	O60841	IF2P_HUMAN	eukaryotic translation initiation factor 5B	296					regulation of translational initiation	cytosol	GTP binding|GTPase activity|protein binding|translation initiation factor activity			ovary(2)|pancreas(1)	3						TCCTGCCTCTGAAGAGAAAGC	0.368	Colon(162;2388 2567 2705 3444)		NA											6	131					0	0	0.001984	0	0
EIF5B	9669	broad.mit.edu	37	2	99980189	99980189	+	Missense_Mutation	SNP	A	A	C			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr2:99980189A>C	uc002tab.2	+	5	1185	c.1001A>C	c.(1000-1002)AAA>ACA	p.K334T		NM_015904	NP_056988	O60841	IF2P_HUMAN	eukaryotic translation initiation factor 5B	334					regulation of translational initiation	cytosol	GTP binding|GTPase activity|protein binding|translation initiation factor activity			ovary(2)|pancreas(1)	3						gagaagaaaaaaggaCCTAGC	0.259	Colon(162;2388 2567 2705 3444)		NA											24	29					0	0	0.003954	0	0
EIF5B	9669	broad.mit.edu	37	2	99998629	99998629	+	Missense_Mutation	SNP	G	G	C			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr2:99998629G>C	uc002tab.2	+	13	2253	c.2069G>C	c.(2068-2070)AGA>ACA	p.R690T		NM_015904	NP_056988	O60841	IF2P_HUMAN	eukaryotic translation initiation factor 5B	690					regulation of translational initiation	cytosol	GTP binding|GTPase activity|protein binding|translation initiation factor activity			ovary(2)|pancreas(1)	3						TAGTTTGATAGAGAGAATGTA	0.353	Colon(162;2388 2567 2705 3444)		NA											5	60					0	0	0.001984	0	0
TBC1D8	11138	broad.mit.edu	37	2	101646204	101646205	+	Missense_Mutation	DNP	GA	GA	AG			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	GA	GA	-	-	GA	GA	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr2:101646204_101646205GA>AG	uc010fiv.2	-	12	2056_2057	c.1925_1926TC>CT	c.(1924-1926)CTC>CCT	p.L642P	TBC1D8_uc002tau.3_Missense_Mutation_p.L399P	NM_001102426	NP_001095896	O95759	TBCD8_HUMAN	TBC1 domain family, member 8	642	Rab-GAP TBC.				blood circulation|positive regulation of cell proliferation	intracellular|membrane	calcium ion binding|Rab GTPase activator activity			ovary(3)	3						GACCCTTGATGAGCTCCTCGAA	0.554			NA											24	63					0	0	0.004672	0	0
RGPD4	285190	broad.mit.edu	37	2	108488039	108488039	+	Silent	SNP	G	G	A			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr2:108488039G>A	uc010ywk.1	+	20	3661	c.3579G>A	c.(3577-3579)CAG>CAA	p.Q1193Q	RGPD4_uc002tdu.2_Silent_p.Q380Q|RGPD4_uc010ywl.1_RNA	NM_182588	NP_872394	Q7Z3J3	RGPD4_HUMAN	RANBP2-like and GRIP domain containing 4	1193					intracellular transport		binding			skin(2)	2						AGTTAATACAGAGAGCTGAAG	0.388			NA											34	36					0	0	0.011902	0	0
EPB41L5	57669	broad.mit.edu	37	2	120900596	120900596	+	Missense_Mutation	SNP	G	G	C			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr2:120900596G>C	uc002tmg.2	+	19	1743	c.1617G>C	c.(1615-1617)TTG>TTC	p.L539F	EPB41L5_uc010fll.2_Missense_Mutation_p.L539F|EPB41L5_uc010flm.2_Missense_Mutation_p.L343F	NM_020909	NP_065960	Q9HCM4	E41L5_HUMAN	erythrocyte membrane protein band 4.1 like 5	539						cytoplasm|cytoskeleton|extrinsic to membrane	cytoskeletal protein binding			ovary(1)	1						TGGTGAAGTTGACTGAGAAAT	0.348			NA											4	107					0	0	0.009096	0	0
POTEE	445582	broad.mit.edu	37	2	131976380	131976380	+	Silent	SNP	C	C	T			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr2:131976380C>T	uc002tsn.2	+	1	457	c.405C>T	c.(403-405)GTC>GTT	p.V135V	PLEKHB2_uc002tsh.2_Intron|POTEE_uc002tsk.2_5'UTR|POTEE_uc002tsl.2_5'UTR	NM_001083538	NP_001077007	Q6S8J3	POTEE_HUMAN	protein expressed in prostate, ovary, testis,	135							ATP binding				0						GGTACCACGTCCGTGGAGAAG	0.597			NA											31	103					0	0	0.003755	0	0
RIF1	55183	broad.mit.edu	37	2	152303012	152303012	+	Missense_Mutation	SNP	G	G	A			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr2:152303012G>A	uc002txm.2	+	20	2297	c.2167G>A	c.(2167-2169)GCA>ACA	p.A723T	RIF1_uc002txl.2_Missense_Mutation_p.A723T|RIF1_uc010fnv.1_Missense_Mutation_p.A687T|RIF1_uc002txn.2_Missense_Mutation_p.A723T|RIF1_uc002txo.2_Missense_Mutation_p.A723T	NM_018151	NP_060621	Q5UIP0	RIF1_HUMAN	RAP1 interacting factor 1	723					cell cycle|response to DNA damage stimulus	chromosome, telomeric region|cytoplasm|nucleus|spindle	binding			ovary(5)|breast(4)|skin(3)|lung(2)|kidney(1)	15				BRCA - Breast invasive adenocarcinoma(221;0.0429)		TGCTTTGGTGGCAACAGCAGA	0.408			NA											5	230					0	0	0.000602	0	0
ACVR1	90	broad.mit.edu	37	2	158626930	158626930	+	Missense_Mutation	SNP	C	C	T			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr2:158626930C>T	uc002tzm.3	-	8	1079	c.740G>A	c.(739-741)AGG>AAG	p.R247K	ACVR1_uc002tzn.3_Missense_Mutation_p.R247K|ACVR1_uc010fog.2_Missense_Mutation_p.R247K	NM_001111067	NP_001104537	Q04771	ACVR1_HUMAN	activin A receptor, type I precursor	247	Cytoplasmic (Potential).|Protein kinase.				BMP signaling pathway|G1/S transition of mitotic cell cycle|negative regulation of activin receptor signaling pathway|negative regulation of apoptosis|positive regulation of bone mineralization|positive regulation of osteoblast differentiation|positive regulation of transcription, DNA-dependent|transforming growth factor beta receptor signaling pathway	activin receptor complex	activin binding|ATP binding|follistatin binding|metal ion binding|protein homodimerization activity|SMAD binding|transforming growth factor beta binding			ovary(2)|skin(1)	3				BRCA - Breast invasive adenocarcinoma(221;0.104)	Adenosine triphosphate(DB00171)	TTCCGTTTCCCTGAACCATGA	0.463			NA											47	111					0	0	0.01441	0	0
SCN9A	6335	broad.mit.edu	37	2	167168258	167168258	+	Missense_Mutation	SNP	C	C	T			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr2:167168258C>T	uc010fpl.2	-	2	350	c.9G>A	c.(7-9)ATG>ATA	p.M3I		NM_002977	NP_002968	Q15858	SCN9A_HUMAN	sodium channel, voltage-gated, type IX, alpha	3						voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|central_nervous_system(5)|skin(2)	13					Lamotrigine(DB00555)|Lidocaine(DB00281)	GGGGAGGCAACATTGCCATCT	0.418			NA											35	54					0	0	0.00623	0	0
TTN	7273	broad.mit.edu	37	2	179417425	179417425	+	Missense_Mutation	SNP	C	C	G			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr2:179417425C>G	uc010zfg.1	-	284	82722	c.82498G>C	c.(82498-82500)GAA>CAA	p.E27500Q	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.E21195Q|TTN_uc010zfi.1_Missense_Mutation_p.E21128Q|TTN_uc010zfj.1_Missense_Mutation_p.E21003Q	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	28427							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CCTTTCCTTTCTACAACATAT	0.448			NA											4	112					0	0	0.009096	0	0
TTN	7273	broad.mit.edu	37	2	179432168	179432168	+	Missense_Mutation	SNP	C	C	T			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr2:179432168C>T	uc010zfg.1	-	275	71211	c.70987G>A	c.(70987-70989)GAT>AAT	p.D23663N	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.D17358N|TTN_uc010zfi.1_Missense_Mutation_p.D17291N|TTN_uc010zfj.1_Missense_Mutation_p.D17166N	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	24590							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ATTTCCTTATCTCCTCTTAAC	0.378			NA											4	141					0	0	0.009096	0	0
TTN	7273	broad.mit.edu	37	2	179650595	179650595	+	Missense_Mutation	SNP	C	C	T			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr2:179650595C>T	uc010zfg.1	-	14	2574	c.2350G>A	c.(2350-2352)GGA>AGA	p.G784R	TTN_uc010zfh.1_Missense_Mutation_p.G738R|TTN_uc010zfi.1_Missense_Mutation_p.G738R|TTN_uc010zfj.1_Missense_Mutation_p.G738R|TTN_uc002unb.2_Missense_Mutation_p.G784R|TTN_uc010frg.1_Missense_Mutation_p.G366R	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	784							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ATGTGCATTCCCTTTTGATCA	0.463			NA											24	66					0	0	0.004656	0	0
PARD3B	117583	broad.mit.edu	37	2	206023445	206023445	+	Splice_Site	SNP	G	G	C			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr2:206023445G>C	uc002var.1	+	11	1642	c.1435_splice	c.e11-1	p.K479_splice	PARD3B_uc010fub.1_Splice_Site_p.K479_splice|PARD3B_uc002vao.1_Splice_Site_p.K479_splice|PARD3B_uc002vap.1_Intron|PARD3B_uc002vaq.1_Splice_Site_p.K479_splice	NM_152526	NP_689739	Q8TEW8	PAR3L_HUMAN	par-3 partitioning defective 3 homolog B isoform						cell cycle|cell division	endomembrane system|tight junction				skin(2)|ovary(1)|breast(1)	4		all_cancers(1;2.88e-06)|all_epithelial(1;3.23e-06)		Epithelial(149;0.0739)		TCCCCTAACAGAAAGGAGAAC	0.478			NA											4	167					0	0	0.000602	0	0
CRYGB	1419	broad.mit.edu	37	2	209007437	209007437	+	Silent	SNP	C	C	T			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr2:209007437C>T	uc002vcp.3	-	3	486	c.453G>A	c.(451-453)GAG>GAA	p.E151E		NM_005210	NP_005201	P07316	CRGB_HUMAN	crystallin, gamma B	151	Beta/gamma crystallin 'Greek key' 4.				visual perception		structural constituent of eye lens				0				Epithelial(149;0.0641)|LUSC - Lung squamous cell carcinoma(261;0.0703)|Lung(261;0.132)		ACCTCCTGTACTCCCCCGGCC	0.502			NA											28	166					0	0	0.009535	0	0
SPAG16	79582	broad.mit.edu	37	2	214354705	214354705	+	Missense_Mutation	SNP	G	G	C			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr2:214354705G>C	uc002veq.2	+	10	1053	c.961G>C	c.(961-963)GAT>CAT	p.D321H	SPAG16_uc010fuz.1_Missense_Mutation_p.D172H|SPAG16_uc002ver.2_Missense_Mutation_p.D267H|SPAG16_uc010zjk.1_Missense_Mutation_p.D227H	NM_024532	NP_078808	Q8N0X2	SPG16_HUMAN	sperm associated antigen 16 isoform 1	321					cilium assembly	cilium axoneme|flagellar axoneme				ovary(1)|skin(1)	2		Renal(323;0.00461)		UCEC - Uterine corpus endometrioid carcinoma (47;0.0525)|Epithelial(149;7.07e-07)|all cancers(144;7.96e-05)|Lung(261;0.00255)|LUSC - Lung squamous cell carcinoma(224;0.00599)		ATTTCCCATAGATATGCAACC	0.313			NA											10	78					0	0	0.013537	0	0
SPEG	10290	broad.mit.edu	37	2	220344819	220344819	+	Missense_Mutation	SNP	G	G	C			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr2:220344819G>C	uc010fwg.2	+	25	5299	c.5299G>C	c.(5299-5301)GAG>CAG	p.E1767Q		NM_005876	NP_005867	Q15772	SPEG_HUMAN	SPEG complex locus	1767	Protein kinase 1.				muscle organ development|negative regulation of cell proliferation	nucleus	ATP binding|protein serine/threonine kinase activity			stomach(9)|ovary(4)|central_nervous_system(1)	14		Renal(207;0.0183)		Epithelial(149;4.5e-10)|all cancers(144;7.93e-08)|Lung(261;0.00639)|LUSC - Lung squamous cell carcinoma(224;0.00829)|READ - Rectum adenocarcinoma(5;0.163)		TGTAGCACCCGAGATTGTCAA	0.607			NA											6	105					0	0	0.001984	0	0
PANK2	80025	broad.mit.edu	37	20	3897586	3897586	+	Missense_Mutation	SNP	G	G	C			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr20:3897586G>C	uc002wkc.2	+	5	1431	c.1425G>C	c.(1423-1425)ATG>ATC	p.M475I	PANK2_uc002wkb.2_Missense_Mutation_p.M184I|PANK2_uc002wkd.2_RNA|PANK2_uc002wke.2_Missense_Mutation_p.M184I|PANK2_uc002wkf.2_Missense_Mutation_p.M39I|uc002wkg.2_5'Flank|MIR103-2_hsa-mir-103-2|MI0000108_5'Flank	NM_153638	NP_705902	Q9BZ23	PANK2_HUMAN	pantothenate kinase 2 isoform 1 preproprotein	475				M -> K (in Ref. 2; BAB13897).	cell death|coenzyme A biosynthetic process|pantothenate metabolic process	mitochondrial intermembrane space|nucleus	ATP binding|pantothenate kinase activity|protein binding				0						TTGGAAACATGATGAGCAAGG	0.418			NA											3	55					0	0	0.004672	0	0
LRRN4	164312	broad.mit.edu	37	20	6022399	6022399	+	Missense_Mutation	SNP	G	G	C			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr20:6022399G>C	uc002wmo.2	-	5	1716	c.1492C>G	c.(1492-1494)CAG>GAG	p.Q498E		NM_152611	NP_689824	Q8WUT4	LRRN4_HUMAN	leucine rich repeat neuronal 4 precursor	498	Extracellular (Potential).					integral to membrane				skin(3)	3						TGGCCGGGCTGAGGCGAGCTT	0.632			NA											8	209					0	0	0.006214	0	0
ACSS2	55902	broad.mit.edu	37	20	33508916	33508916	+	Missense_Mutation	SNP	G	G	A			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr20:33508916G>A	uc002xbd.2	+	10	1372	c.1251G>A	c.(1249-1251)ATG>ATA	p.M417I	ACSS2_uc002xbc.2_Missense_Mutation_p.M322I|ACSS2_uc010zum.1_Intron|ACSS2_uc010gey.2_Missense_Mutation_p.M430I|ACSS2_uc002xbe.2_Missense_Mutation_p.M125I|ACSS2_uc002xbf.2_Intron	NM_018677	NP_061147	Q9NR19	ACSA_HUMAN	acyl-CoA synthetase short-chain family member 2	417					ethanol oxidation|lipid biosynthetic process|xenobiotic metabolic process	cytosol|nucleus	acetate-CoA ligase activity|ATP binding|protein binding				0					Adenosine monophosphate(DB00131)|Adenosine triphosphate(DB00171)	GTCTGCTCATGAAGTTTGGAG	0.537			NA											9	310					0	0	0.008291	0	0
CHD6	84181	broad.mit.edu	37	20	40122243	40122243	+	Missense_Mutation	SNP	C	C	T			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr20:40122243C>T	uc002xka.1	-	10	1427	c.1249G>A	c.(1249-1251)GAT>AAT	p.D417N	CHD6_uc002xkd.2_Missense_Mutation_p.D395N	NM_032221	NP_115597	Q8TD26	CHD6_HUMAN	chromodomain helicase DNA binding protein 6	417	Chromo 2.				chromatin remodeling|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding			ovary(6)|skin(5)|lung(2)|central_nervous_system(1)	14		Myeloproliferative disorder(115;0.00425)				GGATCTACATCTTCCTCTAGC	0.418			NA											6	127					0	0	0.00308	0	0
PLTP	5360	broad.mit.edu	37	20	44539798	44539798	+	Missense_Mutation	SNP	T	T	C			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr20:44539798T>C	uc002xqn.1	-	3	273	c.193A>G	c.(193-195)ATC>GTC	p.I65V	PLTP_uc002xql.1_5'Flank|PLTP_uc002xqm.1_Missense_Mutation_p.I85V|PLTP_uc002xqo.1_Missense_Mutation_p.I65V|PLTP_uc002xqp.1_Missense_Mutation_p.I65V|PLTP_uc002xqq.1_Missense_Mutation_p.I34V|PLTP_uc010zxj.1_Missense_Mutation_p.I65V|PLTP_uc010ghj.1_Missense_Mutation_p.I65V	NM_006227	NP_006218	P55058	PLTP_HUMAN	phospholipid transfer protein isoform a	65					cellular lipid metabolic process|lipid transport	extracellular region	lipid binding			ovary(1)	1		Myeloproliferative disorder(115;0.0122)				TACTCAGAGATGTTGTAGTAG	0.637			NA											3	133					0	0	0.004672	0	0
FAM65C	140876	broad.mit.edu	37	20	49209728	49209728	+	Missense_Mutation	SNP	G	G	C			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr20:49209728G>C	uc002xvm.2	-	18	2524	c.2206C>G	c.(2206-2208)CGC>GGC	p.R736G	FAM65C_uc010zyt.1_Missense_Mutation_p.R740G|FAM65C_uc010zyu.1_RNA	NM_080829	NP_543019	Q96MK2	FA65C_HUMAN	hypothetical protein LOC140876	736										ovary(2)	2						AGGAGCCTGCGGCACGCTGGC	0.582			NA											18	37					0	0	0.004656	0	0
C20orf200	253868	broad.mit.edu	37	20	61143770	61143770	+	Silent	SNP	C	C	T			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr20:61143770C>T	uc002ycz.1	-	3	569	c.78G>A	c.(76-78)GAG>GAA	p.E26E	C20orf200_uc002ycy.2_RNA	NM_152757	NP_689970			hypothetical protein LOC253868												0	Breast(26;2.05e-08)		BRCA - Breast invasive adenocarcinoma(19;7.17e-06)			AACCGCTGCTCTCCTGCGTCC	0.662			NA											9	129					0	0	0.008291	0	0
SETD4	54093	broad.mit.edu	37	21	37420692	37420692	+	Missense_Mutation	SNP	C	C	G			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr21:37420692C>G	uc002yuw.1	-	4	1583	c.210G>C	c.(208-210)GAG>GAC	p.E70D	SETD4_uc002yux.1_Missense_Mutation_p.E46D|SETD4_uc002yuu.2_Intron|SETD4_uc002yuv.2_Missense_Mutation_p.E70D|SETD4_uc002yuy.2_Missense_Mutation_p.E70D|SETD4_uc002yuz.2_Missense_Mutation_p.E46D|SETD4_uc002yva.2_Missense_Mutation_p.E46D	NM_017438	NP_059134	Q9NVD3	SETD4_HUMAN	SET domain containing 4 isoform a	70	SET.									large_intestine(1)|ovary(1)	2						TCATCTGTCCCTCCTGGCCAA	0.473			NA											139	229					0	0	0.01441	0	0
TRPM2	7226	broad.mit.edu	37	21	45846542	45846542	+	Splice_Site	SNP	G	G	C			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr21:45846542G>C	uc002zet.1	+	27	4009	c.3796_splice	c.e27-1	p.T1266_splice	TRPM2_uc002zeu.1_Splice_Site_p.T1266_splice|TRPM2_uc002zew.1_Splice_Site_p.T1266_splice|TRPM2_uc010gpt.1_Splice_Site_p.T1316_splice|TRPM2_uc002zex.1_Splice_Site_p.T1052_splice|TRPM2_uc002zey.1_Splice_Site_p.T779_splice|uc011afe.1_5'Flank|TRPM2_uc011aff.1_Intron	NM_003307	NP_003298	O94759	TRPM2_HUMAN	transient receptor potential cation channel,							integral to plasma membrane	ADP-ribose diphosphatase activity|calcium channel activity|sodium channel activity			ovary(1)|central_nervous_system(1)|pancreas(1)	3						TTTTGCGACAGACGGAGTTCC	0.587			NA											3	153					0	0	0.009096	0	0
COL18A1	80781	broad.mit.edu	37	21	46908346	46908346	+	Silent	SNP	G	G	T			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr21:46908346G>T	uc011afs.1	+	17	3177	c.3156G>T	c.(3154-3156)CTG>CTT	p.L1052L	COL18A1_uc002zhg.2_Silent_p.L637L|COL18A1_uc002zhi.2_Silent_p.L817L	NM_130444	NP_569711	P39060	COIA1_HUMAN	alpha 1 type XVIII collagen isoform 3 precursor	1052	Triple-helical region 4 (COL4).				cell adhesion|negative regulation of cell proliferation|organ morphogenesis|visual perception	collagen|extracellular space	extracellular matrix structural constituent|metal ion binding|protein binding			central_nervous_system(1)	1				Colorectal(79;0.0157)|READ - Rectum adenocarcinoma(84;0.0929)		CTCCCGGCCTGCCGGGACTTA	0.607			NA											8	129					0.000274275	0.000313901	0.004482	1	0
PI4KA	5297	broad.mit.edu	37	22	21174157	21174157	+	Silent	SNP	C	C	G			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr22:21174157C>G	uc002zsz.3	-	6	618	c.387G>C	c.(385-387)CTG>CTC	p.L129L	PI4KA_uc010gsq.1_Silent_p.L187L	NM_058004	NP_477352	P42356	PI4KA_HUMAN	phosphatidylinositol 4-kinase type 3 alpha	129					phosphatidylinositol biosynthetic process|phosphatidylinositol-mediated signaling|synaptic transmission	Golgi-associated vesicle	1-phosphatidylinositol 4-kinase activity|ATP binding|protein binding			lung(2)|upper_aerodigestive_tract(1)|salivary_gland(1)	4	all_cancers(11;7.59e-25)|all_epithelial(7;1.34e-22)|Melanoma(16;0.000465)|Ovarian(15;0.00167)|Colorectal(54;0.0332)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.000536)|Lung(15;0.0108)|Epithelial(17;0.196)			AGATTCCTATCAGGCATGGGA	0.428	GBM(136;1332 1831 3115 23601 50806)		NA											4	207					0	0	0.001168	0	0
CRKL	1399	broad.mit.edu	37	22	21288146	21288146	+	Missense_Mutation	SNP	C	C	G			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr22:21288146C>G	uc002ztf.2	+	2	900	c.391C>G	c.(391-393)CTG>GTG	p.L131V	CRKL_uc002ztg.1_RNA	NM_005207	NP_005198	P46109	CRKL_HUMAN	v-crk sarcoma virus CT10 oncogene homolog	131	SH3 1.				JNK cascade|Ras protein signal transduction	cytosol	protein tyrosine kinase activity|SH3/SH2 adaptor activity|signal transducer activity				0	all_cancers(11;1.16e-25)|all_epithelial(7;3.37e-24)|Lung NSC(8;7.25e-16)|all_lung(8;1.37e-14)|Melanoma(16;0.000465)|Ovarian(15;0.00167)|Colorectal(54;0.0332)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.000204)|Lung(15;0.00494)|Epithelial(17;0.176)			TGTACGGACTCTGTATGATTT	0.463	Pancreas(85;3 1441 23889 42519 42763)		NA											23	161					0	0	0.00278	0	0
MYO18B	84700	broad.mit.edu	37	22	26317265	26317265	+	Silent	SNP	A	A	G			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr22:26317265A>G	uc003abz.1	+	34	5656	c.5406A>G	c.(5404-5406)AGA>AGG	p.R1802R	MYO18B_uc003aca.1_Silent_p.R1683R|MYO18B_uc010guy.1_Silent_p.R1684R|MYO18B_uc010guz.1_Silent_p.R1682R|MYO18B_uc011aka.1_Silent_p.R956R|MYO18B_uc011akb.1_Silent_p.R1315R	NM_032608	NP_115997	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	1802	Tail.					nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity			ovary(5)|central_nervous_system(3)|large_intestine(2)|breast(2)	12						GACTTCGGAGAGACCTCAGGA	0.488			NA											2	8					0	0	0.004672	0	0
NF2	4771	broad.mit.edu	37	22	30077432	30077432	+	Missense_Mutation	SNP	G	G	C	rs74315505		TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr22:30077432G>C	uc003age.3	+	15	2022	c.1579G>C	c.(1579-1581)GAA>CAA	p.E527Q	NF2_uc003afy.3_Missense_Mutation_p.E527Q|NF2_uc003afz.3_Missense_Mutation_p.E444Q|NF2_uc003agf.3_Missense_Mutation_p.E527Q|NF2_uc003agb.3_Missense_Mutation_p.E450Q|NF2_uc003agc.3_Missense_Mutation_p.E489Q|NF2_uc003agd.3_Intron|NF2_uc003agg.3_Missense_Mutation_p.E527Q|NF2_uc003aga.3_Missense_Mutation_p.E485Q|NF2_uc003agh.3_Missense_Mutation_p.E486Q|NF2_uc003agi.3_Missense_Mutation_p.E444Q|NF2_uc003agj.3_Intron|NF2_uc003agk.3_Missense_Mutation_p.E489Q|NF2_uc010gvp.2_Missense_Mutation_p.E191Q|NF2_uc011akq.1_Missense_Mutation_p.E153Q	NM_000268	NP_000259	P35240	MERL_HUMAN	neurofibromin 2 isoform 1	527					actin cytoskeleton organization|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of cell-cell adhesion|negative regulation of cell-matrix adhesion|negative regulation of DNA replication|negative regulation of tyrosine phosphorylation of Stat3 protein|negative regulation of tyrosine phosphorylation of Stat5 protein|positive regulation of stress fiber assembly|regulation of hippo signaling cascade|Schwann cell proliferation	cytoskeleton|early endosome|extrinsic to membrane|filopodium membrane|nucleolus|perinuclear region of cytoplasm|ruffle membrane	cytoskeletal protein binding|protein binding	p.E527fs*22(2)|p.?(2)|p.G502_I577del(1)|p.K525fs*18(1)		meninges(372)|soft_tissue(284)|central_nervous_system(20)|kidney(10)|pleura(9)|skin(7)|large_intestine(5)|breast(5)|urinary_tract(3)|thyroid(2)|endometrium(2)|ovary(2)|lung(2)|stomach(2)|bone(2)|pituitary(1)	728						CGGCAGAGTGGAATACATGGA	0.527			NA	D|Mis|N|F|S|O		meningioma|acoustic neuroma|renal 	meningioma|acoustic neuroma			Neurofibromatosis_type_2				5	134					0	0	0.001168	0	0
SFI1	9814	broad.mit.edu	37	22	31927083	31927083	+	Missense_Mutation	SNP	G	G	A			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr22:31927083G>A	uc003ale.2	+	4	699	c.306G>A	c.(304-306)ATG>ATA	p.M102I	SFI1_uc003ald.1_Intron|SFI1_uc003alf.2_Missense_Mutation_p.M102I|SFI1_uc003alg.2_Intron|SFI1_uc011alp.1_Intron|SFI1_uc011alq.1_Intron|SFI1_uc003alh.2_Intron	NM_001007467	NP_001007468	A8K8P3	SFI1_HUMAN	spindle assembly associated Sfi1 homolog isoform	102					G2/M transition of mitotic cell cycle	centriole|cytosol				central_nervous_system(1)	1						GGATTCGAATGACTTTTGGAA	0.338			NA											7	169					0	0	0.004482	0	0
SMCR7L	54471	broad.mit.edu	37	22	39910294	39910294	+	Nonsense_Mutation	SNP	C	C	G			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr22:39910294C>G	uc003axx.2	+	6	1856	c.1358C>G	c.(1357-1359)TCA>TGA	p.S453*	SMCR7L_uc003axw.2_Intron|SMCR7L_uc003axy.2_Nonsense_Mutation_p.S275*	NM_019008	NP_061881	Q9NQG6	SMC7L_HUMAN	hypothetical protein LOC54471	453						integral to membrane|mitochondrion				central_nervous_system(1)	1	Melanoma(58;0.04)					CTGTATTGCTCATTGTCTGAG	0.532			NA									OREG0026577	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	3	152					0	0	0.000602	0	0
SRGAP3	9901	broad.mit.edu	37	3	9101977	9101977	+	Missense_Mutation	SNP	G	G	C			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr3:9101977G>C	uc003brf.1	-	6	1415	c.739C>G	c.(739-741)CTG>GTG	p.L247V	SRGAP3_uc003brg.1_Missense_Mutation_p.L247V|SRGAP3_uc003bri.1_RNA|SRGAP3_uc003brk.2_Missense_Mutation_p.L247V|SRGAP3_uc003brj.1_Missense_Mutation_p.L107V	NM_014850	NP_055665	O43295	SRGP2_HUMAN	SLIT-ROBO Rho GTPase activating protein 3	247					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|protein binding		SRGAP3/RAF1(4)	central_nervous_system(4)|skin(3)|urinary_tract(1)|breast(1)	9				OV - Ovarian serous cystadenocarcinoma(96;0.0563)		GTGGCTGCCAGATTGAGCAAG	0.502			NA	T	RAF1	pilocytic astrocytoma								5	138					0	0	0.001984	0	0
IQSEC1	9922	broad.mit.edu	37	3	12961967	12961967	+	Silent	SNP	C	C	G	rs146107147	byFrequency	TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr3:12961967C>G	uc003bxt.2	-	6	2034	c.2025G>C	c.(2023-2025)CGG>CGC	p.R675R	IQSEC1_uc003bxu.3_Silent_p.R553R|IQSEC1_uc011auw.1_Silent_p.R661R	NM_014869	NP_055684	Q6DN90	IQEC1_HUMAN	IQ motif and Sec7 domain 1 isoform b	675	SEC7.				regulation of ARF protein signal transduction	cytoplasm|nucleus	ARF guanyl-nucleotide exchange factor activity			ovary(1)	1						GCTTCATTTTCCGCTCGGGCT	0.582			NA											6	180					0	0	0.001168	0	0
OXSM	54995	broad.mit.edu	37	3	25833286	25833286	+	Missense_Mutation	SNP	G	G	C			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr3:25833286G>C	uc003cdn.2	+	2	882	c.775G>C	c.(775-777)GAT>CAT	p.D259H	NGLY1_uc011awo.1_5'Flank|OXSM_uc011awp.1_5'UTR|OXSM_uc010hfh.2_Intron	NM_017897	NP_060367	Q9NWU1	OXSM_HUMAN	3-oxoacyl-ACP synthase, mitochondrial isoform 1	259					acyl-CoA metabolic process|medium-chain fatty acid biosynthetic process|short-chain fatty acid biosynthetic process	mitochondrion	3-oxoacyl-[acyl-carrier-protein] synthase activity			ovary(1)|breast(1)	2						CACAAACTCAGATCCCAAGTT	0.483			NA											9	122					0	0	0.006214	0	0
AZI2	64343	broad.mit.edu	37	3	28379446	28379446	+	Missense_Mutation	SNP	C	C	G			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr3:28379446C>G	uc003ceb.2	-	4	953	c.421G>C	c.(421-423)GAG>CAG	p.E141Q	AZI2_uc003cec.2_Missense_Mutation_p.E29Q|AZI2_uc003ced.2_Missense_Mutation_p.E141Q|AZI2_uc003cee.3_Missense_Mutation_p.E141Q|AZI2_uc003ceg.2_Missense_Mutation_p.E141Q|AZI2_uc011axd.1_Missense_Mutation_p.E141Q|AZI2_uc003cef.2_Missense_Mutation_p.E141Q	NM_022461	NP_071906	Q9H6S1	AZI2_HUMAN	5-azacytidine induced 2 isoform a	141	Potential.					mitochondrion|plasma membrane				ovary(2)	2						GTTTCCACCTCTGTCCTCAGC	0.328			NA											3	58					0	0	0.009096	0	0
COL7A1	1294	broad.mit.edu	37	3	48605555	48605555	+	Missense_Mutation	SNP	C	C	G			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr3:48605555C>G	uc003ctz.2	-	105	7844	c.7843G>C	c.(7843-7845)GAT>CAT	p.D2615H		NM_000094	NP_000085	Q02388	CO7A1_HUMAN	alpha 1 type VII collagen precursor	2615	Triple-helical region.				cell adhesion|epidermis development	basement membrane|collagen type VII	protein binding|serine-type endopeptidase inhibitor activity			ovary(4)|breast(3)|skin(3)|central_nervous_system(1)	11				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		AAGCCAACATCTCCTTTTTCT	0.542			NA											15	109					0	0	0.004007	0	0
PRICKLE2	166336	broad.mit.edu	37	3	64148775	64148775	+	Missense_Mutation	SNP	C	C	T			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr3:64148775C>T	uc003dmf.2	-	3	761	c.175G>A	c.(175-177)GAG>AAG	p.E59K		NM_198859	NP_942559	Q7Z3G6	PRIC2_HUMAN	prickle-like 2	59	PET.					cytoplasm|nuclear membrane	zinc ion binding			ovary(4)|skin(1)	5		Lung NSC(201;0.136)		BRCA - Breast invasive adenocarcinoma(55;0.000971)|KIRC - Kidney renal clear cell carcinoma(15;0.00443)|Kidney(15;0.00497)		GGGACTTTCTCTTCTGGGAGA	0.488			NA											12	275					0	0	0.010729	0	0
CCDC52	152185	broad.mit.edu	37	3	113225439	113225439	+	Missense_Mutation	SNP	C	C	T			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr3:113225439C>T	uc003eag.3	-	2	305	c.14G>A	c.(13-15)AGA>AAA	p.R5K	CCDC52_uc003eaf.3_RNA|CCDC52_uc011bie.1_Missense_Mutation_p.R17K|CCDC52_uc003eai.1_Missense_Mutation_p.R5K	NM_144718	NP_653319	Q8N0Z3	SPICE_HUMAN	coiled-coil domain containing 52	5					cell division|mitosis	centriole|spindle	protein binding				0						GCGGTTCACTCTGACAAATGA	0.378			NA											4	37					0	0	0.000602	0	0
ATP6V1A	523	broad.mit.edu	37	3	113528247	113528247	+	Missense_Mutation	SNP	G	G	C			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr3:113528247G>C	uc003eao.2	+	15	1893	c.1827G>C	c.(1825-1827)CAG>CAC	p.Q609H	ATP6V1A_uc011bik.1_Missense_Mutation_p.Q576H	NM_001690	NP_001681	P38606	VATA_HUMAN	ATPase, H+ transporting, lysosomal V1 subunit A	609					ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|insulin receptor signaling pathway|transferrin transport	cytosol|integral to plasma membrane|proton-transporting V-type ATPase, V1 domain	ATP binding|hydrogen ion transporting ATP synthase activity, rotational mechanism|proton-transporting ATPase activity, rotational mechanism			ovary(2)|skin(1)	3						AAGACATGCAGAATGCATTCC	0.393			NA											9	93					0	0	0.010729	0	0
PARP15	165631	broad.mit.edu	37	3	122335957	122335957	+	Missense_Mutation	SNP	G	G	A			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr3:122335957G>A	uc003efm.2	+	6	1012	c.946G>A	c.(946-948)GAA>AAA	p.E316K	PARP15_uc003efn.2_Missense_Mutation_p.E190K|PARP15_uc003efo.1_Missense_Mutation_p.E63K|PARP15_uc003efp.1_Missense_Mutation_p.E82K|PARP15_uc011bjt.1_Missense_Mutation_p.E82K	NM_001113523	NP_001106995	Q460N3	PAR15_HUMAN	poly (ADP-ribose) polymerase family, member 15	294	Macro 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	NAD+ ADP-ribosyltransferase activity			lung(3)|upper_aerodigestive_tract(1)|ovary(1)	5				GBM - Glioblastoma multiforme(114;0.0531)		TATAGCCACTGAACAGGTAGA	0.353			NA											6	203					0	0	0.001984	0	0
ZIC4	84107	broad.mit.edu	37	3	147113672	147113672	+	Missense_Mutation	SNP	C	C	G			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr3:147113672C>G	uc003ewd.1	-	3	928	c.655G>C	c.(655-657)GAA>CAA	p.E219Q	ZIC4_uc003ewc.1_Missense_Mutation_p.E149Q|ZIC4_uc011bno.1_Missense_Mutation_p.E269Q	NM_032153	NP_115529	Q8N9L1	ZIC4_HUMAN	zinc finger protein of the cerebellum 4	219	C2H2-type 3.					nucleus	DNA binding|zinc ion binding			upper_aerodigestive_tract(1)|central_nervous_system(1)	2						TTGAGATTTTCTGATCTAGCA	0.532			NA											4	165					0	0	0.009096	0	0
AADACL2	344752	broad.mit.edu	37	3	151475041	151475041	+	Missense_Mutation	SNP	G	G	C			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr3:151475041G>C	uc003ezc.2	+	5	985	c.865G>C	c.(865-867)GAG>CAG	p.E289Q	AADACL2_uc010hvn.2_Missense_Mutation_p.E76Q	NM_207365	NP_997248	Q6P093	ADCL2_HUMAN	arylacetamide deacetylase-like 2 precursor	289						extracellular region|integral to membrane	carboxylesterase activity				0			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0813)			TCTTCTTCCTGAGAAGTATAG	0.413			NA											6	110					0	0	0.001168	0	0
PTX3	5806	broad.mit.edu	37	3	157160340	157160340	+	Missense_Mutation	SNP	C	C	G			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr3:157160340C>G	uc003fbl.3	+	3	861	c.718C>G	c.(718-720)CTC>GTC	p.L240V	VEPH1_uc003fbj.1_Intron|VEPH1_uc003fbk.1_Intron|VEPH1_uc010hvu.1_Intron	NM_002852	NP_002843	P26022	PTX3_HUMAN	pentraxin 3 precursor	240	Pentaxin.				inflammatory response	extracellular region				central_nervous_system(1)	1			Lung(72;0.0272)|LUSC - Lung squamous cell carcinoma(72;0.0461)			CCAGCTGTATCTCAGCTACCA	0.473			NA											3	111					0	0	0.009096	0	0
GNB4	59345	broad.mit.edu	37	3	179132738	179132738	+	Missense_Mutation	SNP	G	G	C			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr3:179132738G>C	uc003fjv.3	-	6	645	c.365C>G	c.(364-366)TCT>TGT	p.S122C	GNB4_uc003fju.3_Missense_Mutation_p.S33C	NM_021629	NP_067642	Q9HAV0	GBB4_HUMAN	guanine nucleotide-binding protein, beta-4	122	WD 2.				cellular response to glucagon stimulus|energy reserve metabolic process	plasma membrane	signal transducer activity			skin(2)	2	all_cancers(143;2.01e-16)|Ovarian(172;0.0172)|Breast(254;0.191)		OV - Ovarian serous cystadenocarcinoma(80;5.78e-26)|GBM - Glioblastoma multiforme(14;0.0169)|BRCA - Breast invasive adenocarcinoma(182;0.237)			GTTATATATAGAGCAGATGTT	0.473	Melanoma(105;1405 1491 7265 20440 33721)		NA											27	196					0	0	0.005443	0	0
YEATS2	55689	broad.mit.edu	37	3	183508768	183508768	+	Missense_Mutation	SNP	G	G	A			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr3:183508768G>A	uc003fly.2	+	21	3292	c.3097G>A	c.(3097-3099)GGA>AGA	p.G1033R	YEATS2_uc003flz.2_Missense_Mutation_p.D112N	NM_018023	NP_060493	Q9ULM3	YETS2_HUMAN	YEATS domain containing 2	1033					histone H3 acetylation|negative regulation of transcription from RNA polymerase II promoter	Ada2/Gcn5/Ada3 transcription activator complex	TBP-class protein binding			ovary(3)|large_intestine(1)	4	all_cancers(143;6.55e-10)|Ovarian(172;0.0303)		all cancers(12;2.38e-42)|Epithelial(37;1.9e-36)|OV - Ovarian serous cystadenocarcinoma(80;6.48e-22)			CACAGTATCCGGTGAGTTGCA	0.428			NA											30	75					0	0	0.006999	0	0
FETUB	26998	broad.mit.edu	37	3	186370114	186370114	+	Silent	SNP	G	G	T			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr3:186370114G>T	uc010hyq.2	+	8	1104	c.843G>T	c.(841-843)GTG>GTT	p.V281V	FETUB_uc011brz.1_Silent_p.V133V|FETUB_uc003fqn.2_Silent_p.V281V|FETUB_uc003fqo.2_Silent_p.V176V|FETUB_uc010hyr.2_Silent_p.V244V|FETUB_uc010hys.2_Silent_p.V133V|FETUB_uc003fqp.3_Silent_p.V216V	NM_014375	NP_055190	Q9UGM5	FETUB_HUMAN	fetuin B precursor	281						extracellular space	cysteine-type endopeptidase inhibitor activity			ovary(1)|lung(1)	2	all_cancers(143;6.64e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;5.73e-20)	GBM - Glioblastoma multiforme(93;0.0479)		TTCCCAAGGTGGAAGAATCCC	0.468			NA											75	150					6.85908e-49	8.6058e-49	0.01441	1	0
BOD1L	259282	broad.mit.edu	37	4	13605037	13605037	+	Missense_Mutation	SNP	G	G	C			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr4:13605037G>C	uc003gmz.1	-	10	3604	c.3487C>G	c.(3487-3489)CAA>GAA	p.Q1163E	BOD1L_uc010idr.1_Missense_Mutation_p.Q500E	NM_148894	NP_683692	Q8NFC6	BOD1L_HUMAN	biorientation of chromosomes in cell division	1163							DNA binding			ovary(5)|breast(1)	6						TCATCCTTTTGAACAGTGGCA	0.373			NA											16	150					0	0	0.006122	0	0
NCAPG	64151	broad.mit.edu	37	4	17818967	17818967	+	Missense_Mutation	SNP	C	C	T			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr4:17818967C>T	uc003gpp.2	+	6	1035	c.859C>T	c.(859-861)CGG>TGG	p.R287W	NCAPG_uc011bxj.1_5'UTR	NM_022346	NP_071741	Q9BPX3	CND3_HUMAN	chromosome condensation protein G	287	HEAT 5.				cell division|mitotic chromosome condensation	condensin complex|cytoplasm|nucleus	protein binding			large_intestine(1)	1				STAD - Stomach adenocarcinoma(129;0.18)		GTTGCTCCATCGGTTGGATGT	0.408			NA											10	167					0	0	0.010729	0	0
KLHL5	51088	broad.mit.edu	37	4	39082722	39082722	+	Splice_Site	SNP	G	G	C			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr4:39082722G>C	uc003gts.2	+	3	780	c.705_splice	c.e3-1	p.R235_splice	KLHL5_uc003gtp.2_Splice_Site_p.R189_splice|KLHL5_uc003gtq.2_Splice_Site_p.R48_splice|KLHL5_uc003gtr.1_Splice_Site_p.R235_splice|KLHL5_uc003gtt.2_Splice_Site_p.R174_splice	NM_015990	NP_057074	Q96PQ7	KLHL5_HUMAN	kelch-like 5 isoform 1							cytoplasm|cytoskeleton	actin binding			ovary(1)	1						TGTGTTCACAGATTGGTGCTC	0.363			NA											5	141					0	0	0.000602	0	0
UGDH	7358	broad.mit.edu	37	4	39505518	39505518	+	Missense_Mutation	SNP	C	C	T			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr4:39505518C>T	uc003guk.1	-	11	1667	c.1351G>A	c.(1351-1353)GAA>AAA	p.E451K	UGDH_uc011byp.1_Missense_Mutation_p.E354K|UGDH_uc003gul.1_Missense_Mutation_p.E384K	NM_003359	NP_003350	O60701	UGDH_HUMAN	UDP-glucose dehydrogenase	451					glycosaminoglycan biosynthetic process|UDP-glucose metabolic process|UDP-glucuronate biosynthetic process|xenobiotic metabolic process	cytosol	electron carrier activity|NAD binding|UDP-glucose 6-dehydrogenase activity			large_intestine(1)|ovary(1)|central_nervous_system(1)|skin(1)	4					NADH(DB00157)	GTTTGTAGTTCATTGTGGAGC	0.328			NA											4	86					0	0	0.001168	0	0
GABRA2	2555	broad.mit.edu	37	4	46307713	46307713	+	Nonsense_Mutation	SNP	G	G	T			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr4:46307713G>T	uc003gxc.3	-	6	1248	c.575C>A	c.(574-576)TCA>TAA	p.S192*	GABRA2_uc010igc.2_Nonsense_Mutation_p.S192*|GABRA2_uc011bzc.1_Nonsense_Mutation_p.S137*|GABRA2_uc003gxe.2_Nonsense_Mutation_p.S192*	NM_001114175	NP_001107647	P47869	GBRA2_HUMAN	gamma-aminobutyric acid A receptor, alpha 2	192	Extracellular (Probable).				gamma-aminobutyric acid signaling pathway|neurotransmitter transport|regulation of neurotransmitter levels	cell junction|chloride channel complex|integral to synaptic vesicle membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			ovary(2)|skin(2)	4					Alprazolam(DB00404)|Bromazepam(DB01558)|Diazepam(DB00829)|Ethchlorvynol(DB00189)|Fludiazepam(DB01567)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	AGTGACCTCTGAAGTTGTATA	0.363			NA											33	41					4.3181e-19	5.25455e-19	0.013726	1	0
REST	5978	broad.mit.edu	37	4	57777211	57777211	+	Missense_Mutation	SNP	C	C	T			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr4:57777211C>T	uc003hch.2	+	2	754	c.407C>T	c.(406-408)TCA>TTA	p.S136L	REST_uc003hci.2_Missense_Mutation_p.S136L|REST_uc003hcj.1_Missense_Mutation_p.S136L|REST_uc010ihf.2_5'UTR	NM_005612	NP_005603	Q13127	REST_HUMAN	RE1-silencing transcription factor	136					cardiac muscle cell myoblast differentiation|cellular response to drug|cellular response to electrical stimulus|cellular response to glucocorticoid stimulus|histone H4 deacetylation|negative regulation by host of viral transcription|negative regulation of aldosterone biosynthetic process|negative regulation of calcium ion-dependent exocytosis|negative regulation of cell proliferation|negative regulation of cortisol biosynthetic process|negative regulation of dense core granule biogenesis|negative regulation of insulin secretion|negative regulation of mesenchymal stem cell differentiation|negative regulation of neurogenesis|negative regulation of neuron differentiation|positive regulation of apoptosis|positive regulation of caspase activity|positive regulation of transcription, DNA-dependent	cytoplasm|transcriptional repressor complex	calcium channel activity|chromatin binding|core promoter proximal region sequence-specific DNA binding|core promoter sequence-specific DNA binding|outward rectifier potassium channel activity|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|zinc ion binding			skin(5)|upper_aerodigestive_tract(1)|ovary(1)|lung(1)|central_nervous_system(1)	9	Glioma(25;0.08)|all_neural(26;0.181)					ATTTACAGTTCAAATAAAGAT	0.473			NA											7	132					0	0	0.001984	0	0
MOBKL1A	92597	broad.mit.edu	37	4	71844961	71844961	+	Nonsense_Mutation	SNP	G	G	T			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr4:71844961G>T	uc003hfw.2	+	5	716	c.526G>T	c.(526-528)GAA>TAA	p.E176*	MOBKL1A_uc011cba.1_Nonsense_Mutation_p.E181*	NM_173468	NP_775739	Q7L9L4	MOL1A_HUMAN	MOB1, Mps One Binder kinase activator-like 1A	176					hippo signaling cascade|protein autophosphorylation	cytoplasm|nucleus	kinase activator activity|kinase binding|metal ion binding				0		all_hematologic(202;0.21)	Lung(101;0.235)			GCTTCAGGAGGAAGCACATCT	0.393			NA											23	152					1.55469e-16	1.88053e-16	0.00333	1	0
THAP9	79725	broad.mit.edu	37	4	83829085	83829085	+	Missense_Mutation	SNP	G	G	A			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr4:83829085G>A	uc003hnt.2	+	4	847	c.728G>A	c.(727-729)AGA>AAA	p.R243K	THAP9_uc003hns.1_Missense_Mutation_p.R99K|THAP9_uc003hnu.1_RNA|THAP9_uc003hnv.2_5'UTR	NM_024672	NP_078948	Q9H5L6	THAP9_HUMAN	THAP domain containing 9	243							DNA binding|metal ion binding			ovary(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	5		Hepatocellular(203;0.114)				TCCATCCTCAGAACGTAAGTG	0.313			NA											4	90					0	0	0.009096	0	0
PHF17	79960	broad.mit.edu	37	4	129792527	129792527	+	Missense_Mutation	SNP	T	T	C			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr4:129792527T>C	uc003igk.2	+	11	1919	c.1639T>C	c.(1639-1641)TCC>CCC	p.S547P	PHF17_uc003igl.2_Missense_Mutation_p.S535P|PHF17_uc011cgy.1_Missense_Mutation_p.S547P	NM_199320	NP_955352	Q6IE81	JADE1_HUMAN	PHD finger protein 17 long isoform	547	Poly-Ser.				apoptosis|histone H3 acetylation|histone H4-K12 acetylation|histone H4-K5 acetylation|histone H4-K8 acetylation|negative regulation of cell growth|regulation of transcription, DNA-dependent|response to stress|transcription, DNA-dependent	histone acetyltransferase complex|mitochondrion	protein binding|zinc ion binding				0						TTCTTCCTGCTCCTCCTCCTC	0.413			NA											8	352					0	0	0.00308	0	0
TIGD4	201798	broad.mit.edu	37	4	153691681	153691681	+	Missense_Mutation	SNP	G	G	A			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr4:153691681G>A	uc003imy.2	-	2	1258	c.476C>T	c.(475-477)TCG>TTG	p.S159L		NM_145720	NP_663772	Q8IY51	TIGD4_HUMAN	tigger transposable element derived 4	159					regulation of transcription, DNA-dependent	chromosome, centromeric region|nucleus	chromatin binding|DNA binding	p.S159S(1)		ovary(1)	1	all_hematologic(180;0.093)					CCAGACAGTCGAAGGGTCTAC	0.358			NA											6	67					0	0	0.001168	0	0
TRIM2	23321	broad.mit.edu	37	4	154215474	154215474	+	Missense_Mutation	SNP	C	C	G			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr4:154215474C>G	uc003ing.2	+	5	743	c.542C>G	c.(541-543)TCT>TGT	p.S181C	TRIM2_uc003inh.2_Missense_Mutation_p.S208C	NM_001130067	NP_001123539	Q9C040	TRIM2_HUMAN	tripartite motif-containing 2 isoform 2	181						cytoplasm	zinc ion binding			central_nervous_system(1)	1	all_hematologic(180;0.093)	Medulloblastoma(177;0.00225)		GBM - Glioblastoma multiforme(119;0.0102)|LUSC - Lung squamous cell carcinoma(193;0.0703)		GAAATAGATTCTGCTCTTCAG	0.388			NA											5	99					0	0	0.001984	0	0
GUCY1A3	2982	broad.mit.edu	37	4	156634681	156634681	+	Silent	SNP	C	C	G			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr4:156634681C>G	uc003iov.2	+	8	2054	c.1518C>G	c.(1516-1518)CTC>CTG	p.L506L	GUCY1A3_uc010iqc.2_Silent_p.L506L|GUCY1A3_uc003iow.2_Silent_p.L506L|GUCY1A3_uc010iqd.2_Silent_p.L505L|GUCY1A3_uc003iox.2_Silent_p.L506L|GUCY1A3_uc003ioz.2_Silent_p.L271L|GUCY1A3_uc003ioy.2_Silent_p.L506L|GUCY1A3_uc010iqe.2_Silent_p.L271L|GUCY1A3_uc003ipa.2_Intron|GUCY1A3_uc003ipb.2_Silent_p.L506L	NM_000856	NP_000847	Q02108	GCYA3_HUMAN	guanylate cyclase 1, soluble, alpha 3 isoform A	506	Guanylate cyclase.				blood circulation|intracellular signal transduction|nitric oxide mediated signal transduction|platelet activation	guanylate cyclase complex, soluble	GTP binding|guanylate cyclase activity|heme binding|receptor activity			central_nervous_system(2)|ovary(1)|skin(1)	4	all_hematologic(180;0.24)	Renal(120;0.0854)		COAD - Colon adenocarcinoma(41;0.17)		TCACCATGCTCAATGCACTGT	0.502			NA											4	52					0	0	0.000602	0	0
TMEM144	55314	broad.mit.edu	37	4	159161476	159161476	+	Silent	SNP	C	C	T			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr4:159161476C>T	uc003ipx.2	+	10	1228	c.708C>T	c.(706-708)TTC>TTT	p.F236F	TMEM144_uc010iqi.2_RNA	NM_018342	NP_060812	Q7Z5S9	TM144_HUMAN	transmembrane protein 144	236	Helical; (Potential).					integral to membrane					0	all_hematologic(180;0.24)	Renal(120;0.0854)		COAD - Colon adenocarcinoma(41;0.0539)		TTGCGCACTTCAGTGGCATCT	0.343			NA											5	90					0	0	0.001168	0	0
SH3RF1	57630	broad.mit.edu	37	4	170017808	170017808	+	Missense_Mutation	SNP	C	C	G			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr4:170017808C>G	uc003isa.1	-	12	2864	c.2529G>C	c.(2527-2529)CAG>CAC	p.Q843H		NM_020870	NP_065921	Q7Z6J0	SH3R1_HUMAN	SH3 domain containing ring finger 1	843	SH3 4.					Golgi apparatus|lamellipodium|perinuclear region of cytoplasm	ligase activity|zinc ion binding			breast(2)|lung(1)	3		Prostate(90;0.00267)|Renal(120;0.0183)		GBM - Glioblastoma multiforme(119;0.0287)		CTGCCTCACTCTGAGGAGGAT	0.393			NA											3	103					0	0	0.004672	0	0
ACSL1	2180	broad.mit.edu	37	4	185697770	185697770	+	Silent	SNP	G	G	C			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr4:185697770G>C	uc003iww.2	-	7	918	c.624C>G	c.(622-624)CTC>CTG	p.L208L	ACSL1_uc011ckm.1_Silent_p.L37L|ACSL1_uc003iwt.1_Silent_p.L208L|ACSL1_uc003iwu.1_Silent_p.L208L|ACSL1_uc011ckn.1_Silent_p.L174L|ACSL1_uc003iwv.1_Silent_p.L208L|ACSL1_uc010ise.1_5'Flank	NM_001995	NP_001986	P33121	ACSL1_HUMAN	acyl-CoA synthetase long-chain family member 1	208	Cytoplasmic (Potential).				digestion|fatty acid metabolic process|long-chain fatty-acyl-CoA biosynthetic process|regulation of fatty acid oxidation|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane|microsome|mitochondrial outer membrane|peroxisomal membrane	ATP binding|long-chain fatty acid-CoA ligase activity			ovary(2)	2		all_lung(41;7.57e-14)|Lung NSC(41;1.81e-13)|Colorectal(36;0.00172)|Hepatocellular(41;0.00826)|Renal(120;0.00988)|Prostate(90;0.0235)|all_hematologic(60;0.0315)|all_neural(102;0.107)|Medulloblastoma(177;0.146)		all cancers(43;1.33e-28)|Epithelial(43;5.3e-25)|OV - Ovarian serous cystadenocarcinoma(60;4.88e-11)|Colorectal(24;3.59e-06)|STAD - Stomach adenocarcinoma(60;2.72e-05)|GBM - Glioblastoma multiforme(59;2.83e-05)|BRCA - Breast invasive adenocarcinoma(30;7.66e-05)|COAD - Colon adenocarcinoma(29;0.000538)|LUSC - Lung squamous cell carcinoma(40;0.008)|READ - Rectum adenocarcinoma(43;0.0419)	Adenosine monophosphate(DB00131)|Adenosine triphosphate(DB00171)	CCTCTAATAAGAGTTTGGCCT	0.418			NA											4	92					0	0	0.000602	0	0
TRIP13	9319	broad.mit.edu	37	5	895027	895027	+	Missense_Mutation	SNP	T	T	C			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr5:895027T>C	uc003jbr.2	+	2	328	c.218T>C	c.(217-219)GTG>GCG	p.V73A	BRD9_uc003jbn.2_5'Flank|BRD9_uc011cmb.1_5'Flank|BRD9_uc003jbo.2_5'Flank|BRD9_uc003jbq.2_5'Flank|BRD9_uc011cmc.1_5'Flank|TRIP13_uc010ite.1_Missense_Mutation_p.V73A	NM_004237	NP_004228	Q15645	PCH2_HUMAN	thyroid hormone receptor interactor 13	73					double-strand break repair|reciprocal meiotic recombination|synaptonemal complex assembly|transcription from RNA polymerase II promoter		ATP binding|identical protein binding|nucleoside-triphosphatase activity|transcription cofactor activity				0			Epithelial(17;0.00147)|OV - Ovarian serous cystadenocarcinoma(19;0.00271)|all cancers(22;0.00622)|Lung(60;0.165)			GTGCAGTCTGTGTCTATTATT	0.368			NA											33	88					0	0	0.003271	0	0
NKD2	85409	broad.mit.edu	37	5	1038130	1038130	+	Missense_Mutation	SNP	C	C	T			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr5:1038130C>T	uc003jbt.1	+	10	1003	c.998C>T	c.(997-999)TCC>TTC	p.S333F	NKD2_uc010itf.1_3'UTR	NM_033120	NP_149111	Q969F2	NKD2_HUMAN	naked cuticle homolog 2	333	Interaction with TGFA.				exocytosis|Wnt receptor signaling pathway	cytoplasmic membrane-bounded vesicle|plasma membrane	calcium ion binding|ubiquitin protein ligase binding				0	Lung NSC(6;2.47e-13)|all_lung(6;1.67e-12)|all_epithelial(6;3.28e-09)		Epithelial(17;0.00093)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|all cancers(22;0.00417)|Lung(60;0.165)			TTCCTCAAGTCCCCCAAGGGC	0.711			NA											5	11					0	0	0.004482	0	0
GOLPH3	64083	broad.mit.edu	37	5	32135777	32135777	+	Missense_Mutation	SNP	C	C	A			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr5:32135777C>A	uc003jhp.1	-	3	658	c.373G>T	c.(373-375)GAT>TAT	p.D125Y		NM_022130	NP_071413	Q9H4A6	GOLP3_HUMAN	golgi phosphoprotein 3	125					cell proliferation|positive regulation of TOR signaling cascade|regulation of mitochondrion organization	cytosol|endosome|Golgi cisterna membrane|mitochondrial intermembrane space|plasma membrane|trans-Golgi network	protein binding			ovary(1)	1						GTTGGAGCATCTGACTTACAG	0.373			NA											45	80					6.08268e-21	7.44667e-21	0.01441	1	0
ADAMTS12	81792	broad.mit.edu	37	5	33684050	33684050	+	Missense_Mutation	SNP	C	C	T			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr5:33684050C>T	uc003jia.1	-	4	908	c.745G>A	c.(745-747)GAG>AAG	p.E249K	ADAMTS12_uc010iuq.1_Missense_Mutation_p.E249K	NM_030955	NP_112217	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1	249	Peptidase M12B.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|kidney(1)	9						ACCAGTGTCTCCACCCATCTC	0.527			NA								HNSCC(64;0.19)			12	76					0	0	0.010729	0	0
ADAMTS12	81792	broad.mit.edu	37	5	33881537	33881537	+	Missense_Mutation	SNP	C	C	T			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr5:33881537C>T	uc003jia.1	-	2	339	c.176G>A	c.(175-177)CGA>CAA	p.R59Q	ADAMTS12_uc010iuq.1_Missense_Mutation_p.R59Q|ADAMTS12_uc003jib.1_Missense_Mutation_p.R59Q	NM_030955	NP_112217	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1	59					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|kidney(1)	9						GGCATCTACTCGGACTGGACC	0.488			NA								HNSCC(64;0.19)			29	211					0	0	0.009535	0	0
SRFBP1	153443	broad.mit.edu	37	5	121355964	121355964	+	Silent	SNP	G	G	A			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr5:121355964G>A	uc003kst.1	+	6	606	c.534G>A	c.(532-534)AAG>AAA	p.K178K		NM_152546	NP_689759	Q8NEF9	SRFB1_HUMAN	serum response factor binding protein 1	178					regulation of transcription, DNA-dependent|transcription, DNA-dependent	perinuclear region of cytoplasm					0		all_cancers(142;0.0124)|Prostate(80;0.0322)	KIRC - Kidney renal clear cell carcinoma(527;0.206)	OV - Ovarian serous cystadenocarcinoma(64;0.000227)|Epithelial(69;0.000365)|all cancers(49;0.00517)		TATTGGCGAAGAAACCAATAC	0.343			NA											36	64					0	0	0.005524	0	0
GDF9	2661	broad.mit.edu	37	5	132197487	132197487	+	Missense_Mutation	SNP	G	G	A			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr5:132197487G>A	uc003kxz.1	-	2	1411	c.1159C>T	c.(1159-1161)CCA>TCA	p.P387S	GDF9_uc011cxj.1_Missense_Mutation_p.P299S	NM_005260	NP_005251	O60383	GDF9_HUMAN	growth differentiation factor 9 precursor	387					female gamete generation|transforming growth factor beta receptor signaling pathway	extracellular space	cytokine activity|growth factor activity			skin(1)	1		all_cancers(142;0.105)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			ACTGCCCTTGGACAGTCCCCT	0.502			NA											4	90					0	0	0.000602	0	0
SMAD5	4090	broad.mit.edu	37	5	135496714	135496714	+	Silent	SNP	C	C	T			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr5:135496714C>T	uc003lbj.1	+	5	1017	c.573C>T	c.(571-573)AGC>AGT	p.S191S	SMAD5_uc003lbk.1_Silent_p.S191S|SMAD5_uc003lbl.1_Silent_p.S191S	NM_001001419	NP_001001419	Q99717	SMAD5_HUMAN	SMAD family member 5	191					BMP signaling pathway|embryonic pattern specification|positive regulation of transcription, DNA-dependent|transforming growth factor beta receptor signaling pathway	cytosol|integral to membrane|transcription factor complex	sequence-specific DNA binding transcription factor activity|transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity|ubiquitin protein ligase binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			CTCCAAACAGCCCTTATCCCC	0.483			NA											78	166					0	0	0.01441	0	0
MATR3	9782	broad.mit.edu	37	5	138661216	138661216	+	Missense_Mutation	SNP	G	G	C			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr5:138661216G>C	uc003ldu.2	+	16	2663	c.2236G>C	c.(2236-2238)GAA>CAA	p.E746Q	MATR3_uc003ldt.2_Missense_Mutation_p.E408Q|MATR3_uc003ldw.2_Missense_Mutation_p.E794Q|MATR3_uc003ldx.2_Missense_Mutation_p.E746Q|MATR3_uc010jfc.2_Missense_Mutation_p.E746Q|MATR3_uc011czb.1_Missense_Mutation_p.E458Q|MATR3_uc003ldz.2_Missense_Mutation_p.E746Q|MATR3_uc003lea.2_Missense_Mutation_p.E746Q|MATR3_uc003leb.2_Missense_Mutation_p.E408Q|MATR3_uc003lec.2_Missense_Mutation_p.E423Q	NM_199189	NP_954659	P43243	MATR3_HUMAN	matrin 3	746						nuclear inner membrane|nuclear matrix	nucleotide binding|protein binding|RNA binding|structural molecule activity|zinc ion binding			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00325)			ACCAGGTGCTGAATCTTCTGA	0.408			NA											5	123					0	0	0.000602	0	0
PCDHA8	56140	broad.mit.edu	37	5	140222271	140222271	+	Silent	SNP	C	C	T			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr5:140222271C>T	uc003lhs.2	+	1	1365	c.1365C>T	c.(1363-1365)TTC>TTT	p.F455F	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhr.1_Silent_p.F455F	NM_018911	NP_061734	Q9Y5H6	PCDA8_HUMAN	protocadherin alpha 8 isoform 1 precursor	455	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			upper_aerodigestive_tract(1)|ovary(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTCCGGCGTTCGCGCAGCCCG	0.672			NA											17	97					0	0	0.007413	0	0
PCDHB3	56132	broad.mit.edu	37	5	140482231	140482231	+	Missense_Mutation	SNP	C	C	G			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr5:140482231C>G	uc003lio.2	+	1	1998	c.1998C>G	c.(1996-1998)TTC>TTG	p.F666L	uc003lin.2_5'Flank	NM_018937	NP_061760	Q9Y5E6	PCDB3_HUMAN	protocadherin beta 3 precursor	666	Extracellular (Potential).|Cadherin 6.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			ovary(1)|pancreas(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TGGACGGCTTCTCCCAGCCCT	0.697			NA											6	102					0	0	0.00308	0	0
PCDHB10	56126	broad.mit.edu	37	5	140574422	140574422	+	Missense_Mutation	SNP	T	T	C			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr5:140574422T>C	uc003lix.2	+	1	2471	c.2297T>C	c.(2296-2298)TTC>TCC	p.F766S		NM_018930	NP_061753	Q9UN67	PCDBA_HUMAN	protocadherin beta 10 precursor	766	Cytoplasmic (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			ovary(1)|skin(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			ACCAGTGAGTTCAAGTTCTTG	0.522			NA											53	88					0	0	0.01441	0	0
PCDHB14	56122	broad.mit.edu	37	5	140603931	140603931	+	Missense_Mutation	SNP	C	C	T			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr5:140603931C>T	uc003ljb.2	+	1	854	c.854C>T	c.(853-855)TCA>TTA	p.S285L	PCDHB14_uc011dal.1_Missense_Mutation_p.S132L	NM_018934	NP_061757	Q9Y5E9	PCDBE_HUMAN	protocadherin beta 14 precursor	285	Extracellular (Potential).|Cadherin 3.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TTCCATGCATCAGAAGATATT	0.393	Ovarian(141;50 1831 27899 33809 37648)		NA											34	64					0	0	0.012213	0	0
PCDHGB3	56102	broad.mit.edu	37	5	140750376	140750376	+	Missense_Mutation	SNP	G	G	C			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr5:140750376G>C	uc003ljw.1	+	1	415	c.415G>C	c.(415-417)GAG>CAG	p.E139Q	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc011dat.1_Missense_Mutation_p.E139Q	NM_018924	NP_061747	Q9Y5G1	PCDGF_HUMAN	protocadherin gamma subfamily B, 3 isoform 1	139	Extracellular (Potential).|Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AAATATCACTGAGCTGGAAAT	0.448			NA											4	283					0	0	0.009096	0	0
RBM27	54439	broad.mit.edu	37	5	145631429	145631429	+	Missense_Mutation	SNP	C	C	G			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr5:145631429C>G	uc003lnz.3	+	9	1601	c.1435C>G	c.(1435-1437)CTG>GTG	p.L479V	RBM27_uc003lny.2_Intron	NM_018989	NP_061862	Q9P2N5	RBM27_HUMAN	RNA binding motif protein 27	479					mRNA processing	cytoplasm|nuclear speck	nucleotide binding|RNA binding|zinc ion binding			central_nervous_system(2)|pancreas(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			CCCTACCCCTCTGGTTCCAGG	0.552			NA											6	297					0	0	0.001984	0	0
G3BP1	10146	broad.mit.edu	37	5	151173756	151173756	+	Missense_Mutation	SNP	A	A	G			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr5:151173756A>G	uc003lun.2	+	5	559	c.388A>G	c.(388-390)ATC>GTC	p.I130V	G3BP1_uc003lum.2_Missense_Mutation_p.I130V|G3BP1_uc011dcu.1_Intron|G3BP1_uc010jhz.2_Intron|G3BP1_uc003luq.2_5'Flank	NM_005754	NP_005745	Q13283	G3BP1_HUMAN	Ras-GTPase-activating protein SH3-domain-binding	130	NTF2.				Ras protein signal transduction|transport	cytosol|nucleus|plasma membrane	ATP binding|ATP-dependent DNA helicase activity|ATP-dependent RNA helicase activity|DNA binding|endonuclease activity|protein binding|RNA binding			skin(3)|ovary(1)	4		all_hematologic(541;0.0338)|Medulloblastoma(196;0.091)	Kidney(363;0.000171)|KIRC - Kidney renal clear cell carcinoma(527;0.000785)			TCACAATGATATCTTCAGATA	0.333			NA											30	117					0	0	0.003271	0	0
SLIT3	6586	broad.mit.edu	37	5	168149326	168149326	+	Silent	SNP	C	C	T			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr5:168149326C>T	uc003mab.2	-	23	2838	c.2418G>A	c.(2416-2418)CTG>CTA	p.L806L	SLIT3_uc010jjg.2_Silent_p.L806L	NM_003062	NP_003053	O75094	SLIT3_HUMAN	slit homolog 3 precursor	806	LRR 19.				apoptosis involved in luteolysis|axon extension involved in axon guidance|cellular response to hormone stimulus|negative chemotaxis|negative regulation of cell growth|negative regulation of chemokine-mediated signaling pathway|response to cortisol stimulus|Roundabout signaling pathway	extracellular space|mitochondrion	calcium ion binding|Roundabout binding			ovary(3)|skin(1)	4	Renal(175;0.000159)|Lung NSC(126;0.0174)|all_lung(126;0.0392)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			GGTTGTAGCTCAGGATCCTGT	0.512	Ovarian(29;311 847 10864 17279 24903)		NA											4	53					0	0	0.009096	0	0
GPRIN1	114787	broad.mit.edu	37	5	176025029	176025029	+	Missense_Mutation	SNP	C	C	T			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr5:176025029C>T	uc003meo.1	-	2	1982	c.1807G>A	c.(1807-1809)GAG>AAG	p.E603K		NM_052899	NP_443131	Q7Z2K8	GRIN1_HUMAN	G protein-regulated inducer of neurite outgrowth	603						growth cone|plasma membrane				ovary(2)	2	all_cancers(89;0.00263)|Renal(175;0.000269)|Lung NSC(126;0.00902)|all_lung(126;0.0142)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			ACTTTTCCCTCTGGGATAGCT	0.572			NA											16	80					0	0	0.004007	0	0
RNF130	55819	broad.mit.edu	37	5	179407141	179407141	+	Missense_Mutation	SNP	C	C	A			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr5:179407141C>A	uc003mll.1	-	4	1160	c.753G>T	c.(751-753)AAG>AAT	p.K251N	RNF130_uc003mlm.1_Missense_Mutation_p.K251N	NM_018434	NP_060904	Q86XS8	GOLI_HUMAN	ring finger protein 130 precursor	251	Cytoplasmic (Potential).				apoptosis	cytoplasm|integral to membrane|nucleus	ubiquitin-protein ligase activity|zinc ion binding			lung(2)|ovary(1)	3	all_cancers(89;5.49e-05)|all_epithelial(37;1.94e-05)|Renal(175;0.000159)|Lung NSC(126;0.00118)|all_lung(126;0.00212)	all_cancers(40;0.0294)|Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			TGTCACCCTTCTTTACTGTCC	0.398	GBM(24;432 554 38471 39699 51728)		NA											6	173					2.0095e-06	2.32618e-06	0.001984	1	0
EXOC2	55770	broad.mit.edu	37	6	637753	637753	+	Silent	SNP	C	C	T			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr6:637753C>T	uc003mtd.2	-	2	200	c.66G>A	c.(64-66)ACG>ACA	p.T22T	EXOC2_uc003mte.2_Silent_p.T22T|EXOC2_uc011dho.1_Intron	NM_018303	NP_060773	Q96KP1	EXOC2_HUMAN	Sec5 protein	22	IPT/TIG.				exocytosis|protein transport					breast(4)|ovary(2)|pancreas(1)	7	Ovarian(93;0.0733)	Breast(5;0.0014)|all_lung(73;0.0697)|all_hematologic(90;0.0897)		OV - Ovarian serous cystadenocarcinoma(45;0.0507)|BRCA - Breast invasive adenocarcinoma(62;0.14)		TTGTGACCTTCGTCCATGGTA	0.532			NA											6	231					0	0	0.001984	0	0
MYLK4	340156	broad.mit.edu	37	6	2685595	2685595	+	Silent	SNP	G	G	A			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr6:2685595G>A	uc003mty.3	-	6	777	c.480C>T	c.(478-480)CAC>CAT	p.H160H		NM_001012418	NP_001012418	Q86YV6	MYLK4_HUMAN	myosin light chain kinase family, member 4	160	Protein kinase.						ATP binding|protein serine/threonine kinase activity			breast(3)|ovary(1)	4	Ovarian(93;0.0412)	all_hematologic(90;0.0897)				TGAGGTTCGCGTGGTCCAGCT	0.577			NA											106	175					0	0	0.01441	0	0
OR2H1	26716	broad.mit.edu	37	6	29430097	29430097	+	Missense_Mutation	SNP	G	G	C			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr6:29430097G>C	uc003nmi.2	+	3	994	c.551G>C	c.(550-552)CGA>CCA	p.R184P	OR2H1_uc003nmj.1_Missense_Mutation_p.R184P|OR2H1_uc010jri.1_Missense_Mutation_p.R106P	NM_030883	NP_112145	Q9GZK4	OR2H1_HUMAN	olfactory receptor, family 2, subfamily H,	184	Extracellular (Potential).			R -> G (in Ref. 6; AAC00188).	sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						TCTCTGATTCGACTCTCCTGT	0.502			NA											8	297					0	0	0.004482	0	0
FLOT1	10211	broad.mit.edu	37	6	30708997	30708997	+	Silent	SNP	C	C	T			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr6:30708997C>T	uc003nrm.2	-	5	488	c.324G>A	c.(322-324)CAG>CAA	p.Q108Q	FLOT1_uc011dmr.1_Intron	NM_005803	NP_005794	O75955	FLOT1_HUMAN	flotillin 1	108						centriolar satellite|endosome|integral to membrane|melanosome|membrane fraction					0						TGATGGCCCTCTGGTGGCCCT	0.597			NA											8	111					0	0	0.00308	0	0
FKBPL	63943	broad.mit.edu	37	6	32097038	32097038	+	Missense_Mutation	SNP	C	C	G			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr6:32097038C>G	uc003nzr.2	-	2	790	c.520G>C	c.(520-522)GAG>CAG	p.E174Q	ATF6B_uc003nzo.2_5'Flank|ATF6B_uc003nzn.2_5'Flank|ATF6B_uc011dpg.1_5'Flank|ATF6B_uc011dph.1_5'Flank	NM_022110	NP_071393	Q9UIM3	FKBPL_HUMAN	WAF-1/CIP1 stabilizing protein 39	174					response to radiation	membrane|nucleus	FK506 binding|peptidyl-prolyl cis-trans isomerase activity				0						AGCTGAAGCTCTGCTTCCTCA	0.572			NA											7	305					0	0	0.001984	0	0
AGER	177	broad.mit.edu	37	6	32150773	32150773	+	Missense_Mutation	SNP	C	C	G			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr6:32150773C>G	uc003oal.1	-	6	560	c.536G>C	c.(535-537)AGA>ACA	p.R179T	AGER_uc003oak.1_5'Flank|AGER_uc003oar.2_Missense_Mutation_p.R78T|AGER_uc011dpm.1_Missense_Mutation_p.R78T|AGER_uc011dpn.1_Missense_Mutation_p.R78T|AGER_uc010jtv.1_Missense_Mutation_p.R179T|AGER_uc011dpo.1_Missense_Mutation_p.R92T|AGER_uc003oam.1_Intron|AGER_uc003oan.1_Missense_Mutation_p.R165T|AGER_uc003oap.1_Missense_Mutation_p.R195T|AGER_uc003oat.1_Missense_Mutation_p.R195T|AGER_uc003oao.1_RNA|AGER_uc003oaq.1_Missense_Mutation_p.R165T|AGER_uc010jtw.1_RNA|AGER_uc003oas.1_Missense_Mutation_p.R179T|AGER_uc003oau.1_Missense_Mutation_p.R179T|AGER_uc011dpp.1_Missense_Mutation_p.R179T|AGER_uc011dpq.1_Missense_Mutation_p.R195T	NM_001136	NP_001127	Q15109	RAGE_HUMAN	advanced glycosylation end product-specific	179	Extracellular (Potential).|Ig-like C2-type 1.				cell surface receptor linked signaling pathway|inflammatory response|innate immune response|neuron projection development|positive regulation of NF-kappaB transcription factor activity	integral to plasma membrane	S100 alpha binding|transmembrane receptor activity			breast(1)	1						CTCAGGGTGTCTCCTGGTCTG	0.572			NA											19	88					0	0	0.008871	0	0
AGER	177	broad.mit.edu	37	6	32150922	32150922	+	Silent	SNP	C	C	T			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr6:32150922C>T	uc003oal.1	-	5	501	c.477G>A	c.(475-477)TTG>TTA	p.L159L	AGER_uc003oak.1_5'Flank|AGER_uc003oar.2_Silent_p.L58L|AGER_uc011dpm.1_Silent_p.L58L|AGER_uc011dpn.1_Silent_p.L58L|AGER_uc010jtv.1_Silent_p.L159L|AGER_uc011dpo.1_Silent_p.L72L|AGER_uc003oam.1_Intron|AGER_uc003oan.1_Silent_p.L145L|AGER_uc003oap.1_Silent_p.L175L|AGER_uc003oat.1_Silent_p.L175L|AGER_uc003oao.1_RNA|AGER_uc003oaq.1_Silent_p.L145L|AGER_uc010jtw.1_RNA|AGER_uc003oas.1_Silent_p.L159L|AGER_uc003oau.1_Silent_p.L159L|AGER_uc011dpp.1_Silent_p.L159L|AGER_uc011dpq.1_Silent_p.L175L|AGER_uc011dpr.1_Silent_p.L159L	NM_001136	NP_001127	Q15109	RAGE_HUMAN	advanced glycosylation end product-specific	159	Extracellular (Potential).|Ig-like C2-type 1.				cell surface receptor linked signaling pathway|inflammatory response|innate immune response|neuron projection development|positive regulation of NF-kappaB transcription factor activity	integral to plasma membrane	S100 alpha binding|transmembrane receptor activity			breast(1)	1						GCTTCCCATCCAAGTGCCAGC	0.552			NA											6	111					0	0	0.00308	0	0
RGL2	5863	broad.mit.edu	37	6	33263957	33263957	+	Missense_Mutation	SNP	C	C	T			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr6:33263957C>T	uc003odv.2	-	6	749	c.616G>A	c.(616-618)GAC>AAC	p.D206N	RGL2_uc003odu.2_5'UTR|RGL2_uc010jur.2_Intron|RGL2_uc003odw.2_Missense_Mutation_p.D124N|RGL2_uc011drb.1_Missense_Mutation_p.D124N	NM_004761	NP_004752	O15211	RGL2_HUMAN	ral guanine nucleotide dissociation	206	N-terminal Ras-GEF.				Ras protein signal transduction|regulation of small GTPase mediated signal transduction	intracellular	Ras guanyl-nucleotide exchange factor activity			skin(3)|lung(1)|breast(1)|pancreas(1)	6						CGGATGAGGTCAGCGCTGCCC	0.652			NA											11	282					0	0	0.00245	0	0
FGD2	221472	broad.mit.edu	37	6	36993601	36993601	+	Missense_Mutation	SNP	G	G	A			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr6:36993601G>A	uc010jwp.1	+	14	1663	c.1492G>A	c.(1492-1494)GAA>AAA	p.E498K	FGD2_uc003ong.2_Missense_Mutation_p.E220K|FGD2_uc011dtv.1_Missense_Mutation_p.E126K|FGD2_uc003onj.1_Missense_Mutation_p.E75K	NM_173558	NP_775829	Q7Z6J4	FGD2_HUMAN	FYVE, RhoGEF and PH domain containing 2	498	FYVE-type.				actin cytoskeleton organization|apoptosis|filopodium assembly|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Cdc42 GTPase activity|regulation of cell shape|small GTPase mediated signal transduction	cytoskeleton|cytosol|early endosome membrane|Golgi apparatus|lamellipodium|nucleus|ruffle membrane	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			upper_aerodigestive_tract(1)|lung(1)|pancreas(1)	3						CTACCGGGCCGAACTGAAATA	0.622			NA											5	73					0	0	0.000602	0	0
TTBK1	84630	broad.mit.edu	37	6	43251404	43251404	+	Nonsense_Mutation	SNP	C	C	T			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr6:43251404C>T	uc003ouq.1	+	14	3205	c.2926C>T	c.(2926-2928)CGA>TGA	p.R976*		NM_032538	NP_115927	Q5TCY1	TTBK1_HUMAN	tau tubulin kinase 1	976						cell junction|cytoplasm|nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			lung(4)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	9			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0125)|OV - Ovarian serous cystadenocarcinoma(102;0.0399)			GGAGGGGGCCCGAGCGCCCCT	0.687			NA											28	34					0	0	0.007291	0	0
GSTA3	2940	broad.mit.edu	37	6	52764737	52764737	+	Missense_Mutation	SNP	C	C	G			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr6:52764737C>G	uc003pbb.2	-	5	488	c.409G>C	c.(409-411)GAA>CAA	p.E137Q	GSTA3_uc010jzq.2_Missense_Mutation_p.E81Q	NM_000847	NP_000838	Q16772	GSTA3_HUMAN	glutathione S-transferase alpha 3	137	GST C-terminal.				glutathione metabolic process|xenobiotic metabolic process	cytosol	glutathione transferase activity				0	Lung NSC(77;0.0912)				Glutathione(DB00143)	CCTACTTTTTCGAAGGCAGGG	0.448			NA											8	450					0	0	0.00308	0	0
MYO6	4646	broad.mit.edu	37	6	76551060	76551060	+	Missense_Mutation	SNP	G	G	A			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr6:76551060G>A	uc003pih.1	+	9	1060	c.781G>A	c.(781-783)GAA>AAA	p.E261K	MYO6_uc003pig.1_Missense_Mutation_p.E261K|MYO6_uc003pii.1_Missense_Mutation_p.E261K	NM_004999	NP_004990	Q9UM54	MYO6_HUMAN	myosin VI	261	Myosin head-like.				actin filament-based movement|DNA damage response, signal transduction by p53 class mediator|endocytosis|intracellular protein transport|positive regulation of transcription from RNA polymerase II promoter|regulation of secretion|sensory perception of sound|synaptic transmission	cell cortex|clathrin coated vesicle membrane|coated pit|cytosol|DNA-directed RNA polymerase II, holoenzyme|filamentous actin|Golgi apparatus|nuclear membrane|perinuclear region of cytoplasm|ruffle membrane|unconventional myosin complex	actin filament binding|ADP binding|ATP binding|calmodulin binding|minus-end directed microfilament motor activity|protein binding			kidney(1)|pancreas(1)	2		all_hematologic(105;0.189)		BRCA - Breast invasive adenocarcinoma(397;0.223)		AGATATTAGAGAAAAACTTCA	0.274			NA											5	60					0	0	0.000602	0	0
IMPG1	3617	broad.mit.edu	37	6	76660781	76660781	+	Missense_Mutation	SNP	G	G	C			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr6:76660781G>C	uc003pik.1	-	13	1452	c.1322C>G	c.(1321-1323)TCT>TGT	p.S441C		NM_001563	NP_001554	Q17R60	IMPG1_HUMAN	interphotoreceptor matrix proteoglycan 1	441					visual perception	proteinaceous extracellular matrix	extracellular matrix structural constituent|receptor activity			ovary(2)|skin(1)	3		Acute lymphoblastic leukemia(125;0.0418)|all_hematologic(105;0.222)				CAGGGAGGTAGAGGCCATAGC	0.438	Pancreas(37;839 1141 2599 26037)		NA											4	101					0	0	0.009096	0	0
AIM1	202	broad.mit.edu	37	6	106968226	106968226	+	Missense_Mutation	SNP	G	G	A			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr6:106968226G>A	uc003prh.2	+	2	2406	c.1919G>A	c.(1918-1920)AGA>AAA	p.R640K		NM_001624	NP_001615	Q9Y4K1	AIM1_HUMAN	absent in melanoma 1	640							sugar binding			breast(4)|ovary(2)|upper_aerodigestive_tract(1)|large_intestine(1)|skin(1)	9	Breast(9;0.0138)|all_epithelial(6;0.169)	all_cancers(87;4.67e-25)|all_epithelial(87;5.46e-21)|Acute lymphoblastic leukemia(125;2.15e-07)|all_hematologic(75;5.28e-06)|Colorectal(196;3.46e-05)|all_lung(197;5.94e-05)|Lung NSC(302;7.26e-05)|Ovarian(999;0.00473)	Epithelial(6;0.00114)|all cancers(7;0.00726)|BRCA - Breast invasive adenocarcinoma(8;0.0114)|OV - Ovarian serous cystadenocarcinoma(5;0.0305)	all cancers(137;1.73e-50)|Epithelial(106;2.42e-48)|OV - Ovarian serous cystadenocarcinoma(136;1.51e-27)|BRCA - Breast invasive adenocarcinoma(108;0.00104)|GBM - Glioblastoma multiforme(226;0.00858)		CAGGGCAGCAGAACACCCCTG	0.532			NA											8	90					0	0	0.00308	0	0
REV3L	5980	broad.mit.edu	37	6	111695225	111695225	+	Nonsense_Mutation	SNP	C	C	A			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr6:111695225C>A	uc003puy.3	-	13	4656	c.4333G>T	c.(4333-4335)GGA>TGA	p.G1445*	REV3L_uc003pux.3_Nonsense_Mutation_p.G1367*|REV3L_uc003puz.3_Nonsense_Mutation_p.G1367*	NM_002912	NP_002903	O60673	DPOLZ_HUMAN	DNA polymerase zeta	1445					DNA-dependent DNA replication|translesion synthesis	nucleus|zeta DNA polymerase complex	DNA binding|DNA-directed DNA polymerase activity|metal ion binding|nucleotide binding			large_intestine(2)|ovary(2)|skin(2)	6		all_cancers(87;7.57e-06)|Acute lymphoblastic leukemia(125;2.46e-08)|all_hematologic(75;1.08e-06)|all_epithelial(87;0.00138)|Colorectal(196;0.021)		OV - Ovarian serous cystadenocarcinoma(136;0.0314)|Epithelial(106;0.057)|all cancers(137;0.0663)		GCTGTATTTCCCGGAGAACAA	0.428			NA						DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage					56	133					6.3091e-27	7.81864e-27	0.01441	1	0
VGLL2	245806	broad.mit.edu	37	6	117589584	117589584	+	Silent	SNP	G	G	A			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr6:117589584G>A	uc003pxn.2	+	2	511	c.321G>A	c.(319-321)CTG>CTA	p.L107L	VGLL2_uc003pxo.2_Silent_p.L107L	NM_182645	NP_872586	Q8N8G2	VGLL2_HUMAN	vestigial-like 2 isoform 1	107					transcription, DNA-dependent	nucleus				central_nervous_system(1)	1				GBM - Glioblastoma multiforme(226;0.0254)|all cancers(137;0.0676)|OV - Ovarian serous cystadenocarcinoma(136;0.0757)		GCAGGGCCCTGAGCCAACCCA	0.597			NA											6	47					0	0	0.001984	0	0
MCM9	254394	broad.mit.edu	37	6	119245037	119245037	+	Nonsense_Mutation	SNP	G	G	C			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr6:119245037G>C	uc003pyh.2	-	3	823	c.560C>G	c.(559-561)TCA>TGA	p.S187*		NM_153255	NP_694987	Q9NXL9	MCM9_HUMAN	minichromosome maintenance complex component 9	187					DNA replication		ATP binding|DNA binding|nucleoside-triphosphatase activity			ovary(1)	1		all_cancers(87;0.122)|all_epithelial(87;0.179)		GBM - Glioblastoma multiforme(226;0.0676)|OV - Ovarian serous cystadenocarcinoma(136;0.194)		AGACAAGCCTGAGAGGCAAGT	0.418			NA											3	115					0	0	0.004672	0	0
VIP	7432	broad.mit.edu	37	6	153076459	153076459	+	Nonsense_Mutation	SNP	C	C	T			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr6:153076459C>T	uc003qpe.2	+	4	458	c.286C>T	c.(286-288)CAA>TAA	p.Q96*	VIP_uc003qpf.2_Nonsense_Mutation_p.Q96*|VIP_uc010kjd.2_Nonsense_Mutation_p.Q96*	NM_003381	NP_003372	P01282	VIP_HUMAN	vasoactive intestinal peptide isoform 1	96				QL -> PP (in Ref. 8; AAA61286).	body fluid secretion|G-protein coupled receptor protein signaling pathway|positive regulation of cell proliferation	extracellular region	neuropeptide hormone activity				0		Ovarian(120;0.0654)		OV - Ovarian serous cystadenocarcinoma(155;4.5e-11)|BRCA - Breast invasive adenocarcinoma(81;0.144)		ACTCTTGGGTCAACTTTCTGC	0.318			NA											6	53					0	0	0.004482	0	0
FBXO5	26271	broad.mit.edu	37	6	153296529	153296529	+	Missense_Mutation	SNP	C	C	T			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr6:153296529C>T	uc003qpg.2	-	2	440	c.331G>A	c.(331-333)GAA>AAA	p.E111K	FBXO5_uc003qph.2_Missense_Mutation_p.E65K	NM_012177	NP_036309	Q9UKT4	FBX5_HUMAN	F-box only protein 5 isoform a	111					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|mitotic metaphase/anaphase transition|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of mitotic cell cycle|regulation of transcription involved in G1/S phase of mitotic cell cycle	cytosol|nucleoplasm|spindle	metal ion binding|protein binding				0		Ovarian(120;0.125)		OV - Ovarian serous cystadenocarcinoma(155;4.38e-10)|BRCA - Breast invasive adenocarcinoma(81;0.0893)		CGCTTGCTTTCAGTTTCAAGT	0.383	NSCLC(121;372 1757 17721 17977 29669)		NA											15	104					0	0	0.004007	0	0
SYNJ2	8871	broad.mit.edu	37	6	158487540	158487540	+	Silent	SNP	C	C	A			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr6:158487540C>A	uc003qqx.1	+	12	1665	c.1590C>A	c.(1588-1590)ATC>ATA	p.I530I	SYNJ2_uc011efm.1_RNA|SYNJ2_uc003qqw.1_Silent_p.I530I|SYNJ2_uc003qqy.1_Silent_p.I243I|SYNJ2_uc011efn.1_Silent_p.I458I|SYNJ2_uc010kjo.1_Silent_p.I479I|SYNJ2_uc003qqz.1_Silent_p.I147I	NM_003898	NP_003889	O15056	SYNJ2_HUMAN	synaptojanin 2	530	Catalytic (By similarity).						nucleotide binding|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|RNA binding			skin(1)	1				OV - Ovarian serous cystadenocarcinoma(65;4.42e-18)|BRCA - Breast invasive adenocarcinoma(81;4.23e-05)		TCAAGCGGATCCGGATTGCTA	0.547			NA											13	153					9.05144e-12	1.08189e-11	0.001855	1	0
MAP3K4	4216	broad.mit.edu	37	6	161470151	161470151	+	Missense_Mutation	SNP	T	T	G			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr6:161470151T>G	uc003qtn.2	+	3	989	c.847T>G	c.(847-849)TTT>GTT	p.F283V	MAP3K4_uc010kkc.1_Missense_Mutation_p.F283V|MAP3K4_uc003qto.2_Missense_Mutation_p.F283V|MAP3K4_uc011efz.1_RNA|MAP3K4_uc011ega.1_5'UTR	NM_005922	NP_005913	Q9Y6R4	M3K4_HUMAN	mitogen-activated protein kinase kinase kinase 4	283					activation of MAPKK activity|JNK cascade|positive regulation of JUN kinase activity	perinuclear region of cytoplasm	ATP binding|MAP kinase kinase kinase activity|metal ion binding|protein binding			ovary(3)|lung(3)|skin(2)|stomach(1)	9		Breast(66;0.000776)|Ovarian(120;0.0367)|Prostate(117;0.0771)		OV - Ovarian serous cystadenocarcinoma(65;1.85e-18)|BRCA - Breast invasive adenocarcinoma(81;3.04e-05)		CCAGGACTTCTTTTTATATAC	0.433			NA											7	76					0	0	0.004482	0	0
DNAH11	8701	broad.mit.edu	37	7	21923947	21923947	+	Silent	SNP	C	C	T			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr7:21923947C>T	uc003svc.2	+	77	12478	c.12447C>T	c.(12445-12447)ATC>ATT	p.I4149I		NM_003777	NP_003768	Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	4149					microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(8)|large_intestine(3)|pancreas(3)|central_nervous_system(1)	15						TTGGTGAGATCATGTATGGAG	0.448			NA							Kartagener_syndrome				11	74					0	0	0.013537	0	0
AOAH	313	broad.mit.edu	37	7	36656065	36656065	+	Missense_Mutation	SNP	C	C	T			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr7:36656065C>T	uc003tfh.3	-	11	1168	c.767G>A	c.(766-768)GGA>GAA	p.G256E	AOAH_uc010kxf.2_Missense_Mutation_p.G256E|AOAH_uc011kba.1_Missense_Mutation_p.G224E	NM_001637	NP_001628	P28039	AOAH_HUMAN	acyloxyacyl hydrolase precursor	256					inflammatory response|lipid metabolic process	extracellular region	acyloxyacyl hydrolase activity|lipoprotein lipase activity			skin(1)	1						CAAAATGATTCCCCTGGGCTG	0.448			NA											4	33					0	0	0.001168	0	0
C7orf36	57002	broad.mit.edu	37	7	39610115	39610115	+	Missense_Mutation	SNP	G	G	C			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr7:39610115G>C	uc003thc.3	+	2	149	c.140G>C	c.(139-141)AGA>ACA	p.R47T		NM_020192	NP_064577	Q9NRH1	CG036_HUMAN	hypothetical protein LOC57002	47											0						GAAGGTTATAGAGATGGAATA	0.368			NA											4	154					0	0	0.009096	0	0
CDK13	8621	broad.mit.edu	37	7	40134077	40134077	+	Missense_Mutation	SNP	C	C	G			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr7:40134077C>G	uc003thh.3	+	14	4319	c.4037C>G	c.(4036-4038)TCT>TGT	p.S1346C	CDK13_uc003thi.3_Missense_Mutation_p.S1286C|CDK13_uc003thj.2_Missense_Mutation_p.S397C|CDK13_uc003thk.2_Missense_Mutation_p.S279C	NM_003718	NP_003709	Q14004	CDK13_HUMAN	cell division cycle 2-like 5 isoform 1	1346					alternative nuclear mRNA splicing, via spliceosome|hemopoiesis|interspecies interaction between organisms|phosphorylation of RNA polymerase II C-terminal domain|positive regulation of cell proliferation|regulation of mitosis	nuclear cyclin-dependent protein kinase holoenzyme complex|nuclear speck	ATP binding|cyclin-dependent protein kinase activity|protein binding|RNA polymerase II carboxy-terminal domain kinase activity			lung(2)|skin(2)|ovary(1)	5						TCTTTCTCTTCTGCTCCTTAT	0.428			NA											4	139					0	0	0.000602	0	0
DYNC1I1	1780	broad.mit.edu	37	7	95614143	95614143	+	Missense_Mutation	SNP	G	G	C			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr7:95614143G>C	uc003uoc.3	+	8	925	c.648G>C	c.(646-648)TTG>TTC	p.L216F	DYNC1I1_uc003uod.3_Missense_Mutation_p.L199F|DYNC1I1_uc003uob.2_Missense_Mutation_p.L179F|DYNC1I1_uc003uoe.3_Missense_Mutation_p.L196F|DYNC1I1_uc010lfl.2_Missense_Mutation_p.L205F	NM_004411	NP_004402	O14576	DC1I1_HUMAN	dynein, cytoplasmic 1, intermediate chain 1	216					vesicle transport along microtubule	condensed chromosome kinetochore|cytoplasmic dynein complex|microtubule|perinuclear region of cytoplasm|spindle pole|vesicle	microtubule binding|microtubule motor activity			ovary(3)|kidney(1)	4	all_cancers(62;9.39e-10)|all_epithelial(64;2.28e-09)|Lung NSC(181;0.165)|all_lung(186;0.191)		STAD - Stomach adenocarcinoma(171;0.0957)			CAAGAGAGTTGACAGAGGAAG	0.368			NA											40	67					0	0	0.009718	0	0
MUC17	140453	broad.mit.edu	37	7	100683576	100683576	+	Missense_Mutation	SNP	C	C	A			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr7:100683576C>A	uc003uxp.1	+	3	8932	c.8879C>A	c.(8878-8880)ACC>AAC	p.T2960N	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	2960	Extracellular (Potential).|Ser-rich.|48.|59 X approximate tandem repeats.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					ACACCTGTCACCACTTCTGCT	0.483			NA											131	236					8.93811e-64	1.13197e-63	0.01441	1	0
NUP205	23165	broad.mit.edu	37	7	135310104	135310104	+	Splice_Site	SNP	G	G	T			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr7:135310104G>T	uc003vsw.2	+	32	4702	c.4671_splice	c.e32+1	p.M1557_splice	NUP205_uc003vsx.2_Splice_Site	NM_015135	NP_055950	Q92621	NU205_HUMAN	nucleoporin 205kDa						carbohydrate metabolic process|glucose transport|mRNA transport|protein import into nucleus, docking|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear pore	protein binding			ovary(3)|breast(1)|central_nervous_system(1)|skin(1)	6						ATCTAAAATGGTAAGGCTTTC	0.368			NA											46	73					9.52127e-25	1.17633e-24	0.01441	1	0
GSTK1	373156	broad.mit.edu	37	7	142960620	142960620	+	Missense_Mutation	SNP	C	C	A			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr7:142960620C>A	uc003wci.2	+	1	99	c.14C>A	c.(13-15)CCG>CAG	p.P5Q	GSTK1_uc011ksy.1_Missense_Mutation_p.P5Q|GSTK1_uc003wcj.2_Missense_Mutation_p.P5Q|GSTK1_uc011ksz.1_Missense_Mutation_p.P5Q	NM_015917	NP_057001	Q9Y2Q3	GSTK1_HUMAN	glutathione S-transferase kappa 1 isoform a	5						outer membrane-bounded periplasmic space|peroxisome	glutathione transferase activity|identical protein binding|protein disulfide oxidoreductase activity				0	Melanoma(164;0.059)				Glutathione(DB00143)	GGGCCCCTGCCGCGCACCGTG	0.677			NA											6	133					8.12818e-05	9.32894e-05	0.001984	1	0
SLC4A2	6522	broad.mit.edu	37	7	150773144	150773144	+	Silent	SNP	C	C	G	rs150666646		TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr7:150773144C>G	uc003wit.3	+	22	3772	c.3516C>G	c.(3514-3516)CTC>CTG	p.L1172L	SLC4A2_uc011kve.1_Silent_p.L1163L|SLC4A2_uc003wiu.3_Silent_p.L1158L|SLC4A2_uc003wiv.3_Silent_p.L366L|uc011kvf.1_Missense_Mutation_p.E101Q	NM_003040	NP_003031	P04920	B3A2_HUMAN	solute carrier family 4, anion exchanger, member	1172	Membrane (anion exchange).|Helical; (Potential).				bicarbonate transport	integral to membrane|membrane fraction	inorganic anion exchanger activity				0			OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		TGCAGCTGCTCTGCCTGGCCC	0.667			NA											4	102					0	0	0.009096	0	0
PTPRN2	5799	broad.mit.edu	37	7	157387990	157387990	+	Silent	SNP	C	C	T			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr7:157387990C>T	uc003wno.2	-	17	2557	c.2436G>A	c.(2434-2436)AGG>AGA	p.R812R	PTPRN2_uc003wnp.2_Silent_p.R795R|PTPRN2_uc003wnq.2_Silent_p.R783R|PTPRN2_uc003wnr.2_Silent_p.R774R|PTPRN2_uc011kwa.1_Silent_p.R835R	NM_002847	NP_002838	Q92932	PTPR2_HUMAN	protein tyrosine phosphatase, receptor type, N	812	Cytoplasmic (Potential).|Tyrosine-protein phosphatase.					integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			ovary(4)|large_intestine(1)|pleura(1)|skin(1)	7	all_neural(206;0.181)	all_cancers(7;8.99e-13)|all_epithelial(9;2.4e-06)|all_hematologic(28;0.0155)|Breast(660;0.132)	OV - Ovarian serous cystadenocarcinoma(82;0.00463)	STAD - Stomach adenocarcinoma(7;0.0875)		ACGCGGGGTTCCTCGGGTCGT	0.532			NA											6	91					0	0	0.001984	0	0
CLU	1191	broad.mit.edu	37	8	27462598	27462598	+	Silent	SNP	G	G	A			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr8:27462598G>A	uc003xfw.1	-	4	730	c.672C>T	c.(670-672)CGC>CGT	p.R224R	CLU_uc010lux.1_Silent_p.R89R|CLU_uc003xfx.1_Silent_p.R224R|CLU_uc003xfy.1_Silent_p.R235R|CLU_uc003xfz.1_Silent_p.R276R	NM_203339	NP_976084	P10909	CLUS_HUMAN	clusterin isoform 2	224				R -> L (in Ref. 3; BAG36598).	chaperone-mediated protein folding|complement activation, classical pathway|innate immune response|lipid metabolic process|negative regulation of apoptosis|negative regulation of protein homooligomerization|platelet activation|platelet degranulation|positive regulation of NF-kappaB transcription factor activity|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein stabilization|response to misfolded protein|response to virus|reverse cholesterol transport	chromaffin granule|cytosol|endoplasmic reticulum|microsome|mitochondrial membrane|nucleus|perinuclear region of cytoplasm|platelet alpha granule lumen|spherical high-density lipoprotein particle	misfolded protein binding|ubiquitin protein ligase binding			ovary(2)	2		Ovarian(32;2.61e-05)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0204)|Colorectal(74;0.132)		TGCGGACGATGCGGGACTTGG	0.602			NA											24	82					0	0	0.005443	0	0
FNTA	2339	broad.mit.edu	37	8	42919285	42919285	+	Missense_Mutation	SNP	G	G	C			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr8:42919285G>C	uc003xps.2	+	3	376	c.328G>C	c.(328-330)GAT>CAT	p.D110H	FNTA_uc003xpt.2_Missense_Mutation_p.D19H|FNTA_uc003xpu.2_Intron|FNTA_uc003xpv.2_RNA	NM_002027	NP_002018	P49354	FNTA_HUMAN	farnesyltransferase, CAAX box, alpha isoform a	110					cellular component disassembly involved in apoptosis|positive regulation of deacetylase activity|positive regulation of tubulin deacetylation|protein farnesylation|protein geranylgeranylation|transforming growth factor beta receptor signaling pathway	cytosol|microtubule associated complex	alpha-tubulin binding|CAAX-protein geranylgeranyltransferase activity|microtubule binding|protein farnesyltransferase activity			ovary(1)	1	Prostate(17;0.0119)|Ovarian(28;0.0172)|Lung SC(25;0.184)	all_cancers(86;0.000223)|all_epithelial(80;1.61e-07)|all_lung(54;0.00021)|Lung NSC(58;0.000778)|Hepatocellular(245;0.0524)|Renal(179;0.0822)|Esophageal squamous(32;0.129)	Lung(22;0.0777)|LUSC - Lung squamous cell carcinoma(45;0.17)			CCTGCAGCGTGATGAAAGAAG	0.383			NA											6	239					0	0	0.001168	0	0
SLCO5A1	81796	broad.mit.edu	37	8	70617448	70617448	+	Silent	SNP	G	G	A			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr8:70617448G>A	uc003xyl.2	-	6	2147	c.1440C>T	c.(1438-1440)CCC>CCT	p.P480P	SLCO5A1_uc010lzb.2_Silent_p.P425P|SLCO5A1_uc011lfa.1_Intron|SLCO5A1_uc003xyk.2_Silent_p.P480P|SLCO5A1_uc010lzc.2_Silent_p.P425P	NM_030958	NP_112220	Q9H2Y9	SO5A1_HUMAN	solute carrier organic anion transporter family,	480	Helical; Name=8; (Potential).					integral to membrane|plasma membrane	transporter activity			ovary(3)|upper_aerodigestive_tract(1)	4	Breast(64;0.0654)		Epithelial(68;0.0141)|OV - Ovarian serous cystadenocarcinoma(28;0.0315)|all cancers(69;0.0594)			CACCAGCACTGGGGACGATAA	0.408			NA											4	85					0	0	0.009096	0	0
ZFHX4	79776	broad.mit.edu	37	8	77764427	77764427	+	Missense_Mutation	SNP	C	C	A			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr8:77764427C>A	uc003yav.2	+	10	5522	c.5135C>A	c.(5134-5136)CCA>CAA	p.P1712Q	ZFHX4_uc003yau.1_Missense_Mutation_p.P1757Q|ZFHX4_uc003yaw.1_Missense_Mutation_p.P1712Q	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	1712	Gln-rich.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			TTGGGCTTGCCAGGCTCTGCC	0.512			NA								HNSCC(33;0.089)			21	39					2.39556e-15	2.88898e-15	0.00278	1	0
FAM83H	286077	broad.mit.edu	37	8	144812586	144812586	+	Missense_Mutation	SNP	A	A	C			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr8:144812586A>C	uc003yzk.2	-	2	236	c.167T>G	c.(166-168)CTG>CGG	p.L56R	FAM83H_uc010mfk.1_5'Flank	NM_198488	NP_940890	Q6ZRV2	FA83H_HUMAN	FAM83H	56					biomineral tissue development					lung(1)|central_nervous_system(1)|pancreas(1)	3	all_cancers(97;3.74e-11)|all_epithelial(106;2.62e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;3.38e-41)|Epithelial(56;6.8e-40)|all cancers(56;6.43e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.146)			TTCAGGGCACAGGAAGTCTGG	0.617			NA											26	115					0	0	0.005443	0	0
FBXL6	26233	broad.mit.edu	37	8	145581359	145581359	+	Silent	SNP	G	G	A			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr8:145581359G>A	uc003zcb.2	-	2	529	c.504C>T	c.(502-504)GGC>GGT	p.G168G	C8ORFK29_uc011llb.1_5'Flank|C8ORFK29_uc010mfw.2_5'Flank|C8ORFK29_uc003zby.3_5'Flank|FBXL6_uc003zbz.2_5'UTR|FBXL6_uc003zca.2_Silent_p.G168G|FBXL6_uc010mfx.2_5'UTR|GPR172A_uc003zcc.1_5'Flank|GPR172A_uc003zcd.1_5'Flank|GPR172A_uc003zce.1_5'Flank|GPR172A_uc010mfy.1_5'Flank|GPR172A_uc003zcf.1_5'Flank|GPR172A_uc011llc.1_5'Flank	NM_012162	NP_036294	Q8N531	FBXL6_HUMAN	F-box and leucine-rich repeat protein 6 isoform	168					proteolysis		ubiquitin-protein ligase activity			ovary(1)|lung(1)	2	all_cancers(97;6.64e-12)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;4.43e-40)|Epithelial(56;1.48e-39)|all cancers(56;1.49e-34)|BRCA - Breast invasive adenocarcinoma(115;0.0441)|Colorectal(110;0.055)			TGGCAGGCCGGCCGACCAGCG	0.687			NA											10	50					0	0	0.010729	0	0
RPL8	6132	broad.mit.edu	37	8	146015223	146015223	+	Missense_Mutation	SNP	C	C	A			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr8:146015223C>A	uc003zeb.2	-	6	851	c.740G>T	c.(739-741)CGG>CTG	p.R247L	RPL8_uc003zdz.2_RNA|RPL8_uc003zea.2_Missense_Mutation_p.R211L|RPL8_uc003zec.2_Missense_Mutation_p.R247L	NM_033301	NP_150644	P62917	RL8_HUMAN	ribosomal protein L8	247					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit	rRNA binding|structural constituent of ribosome				0	all_cancers(97;1.03e-11)|all_epithelial(106;6.69e-11)|Lung NSC(106;4.08e-05)|all_lung(105;0.000125)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		Epithelial(56;5.47e-39)|OV - Ovarian serous cystadenocarcinoma(54;6.38e-39)|all cancers(56;5.47e-34)|BRCA - Breast invasive adenocarcinoma(115;0.0355)|Colorectal(110;0.055)	GBM - Glioblastoma multiforme(99;0.191)		CTTGGTTCCCCGGAGACGTCC	0.587			NA											10	593					0.00829132	0.00935668	0.008291	1	0
PSIP1	11168	broad.mit.edu	37	9	15486913	15486913	+	Nonsense_Mutation	SNP	G	G	C			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr9:15486913G>C	uc003zlv.3	-	5	635	c.305C>G	c.(304-306)TCA>TGA	p.S102*	PSIP1_uc003zlw.3_Nonsense_Mutation_p.S102*|PSIP1_uc003zlz.3_Nonsense_Mutation_p.S102*|PSIP1_uc003zma.3_Nonsense_Mutation_p.S102*|PSIP1_uc003zly.2_Nonsense_Mutation_p.S102*	NM_033222	NP_150091	O75475	PSIP1_HUMAN	PC4 and SFRS1 interacting protein 1 isoform 2	102					initiation of viral infection|interspecies interaction between organisms|nuclear mRNA 5'-splice site recognition|provirus integration|regulation of transcription, DNA-dependent|response to heat|response to oxidative stress|transcription, DNA-dependent	cytosol|nuclear heterochromatin|nuclear periphery|nucleoplasm|nucleoplasm|transcriptionally active chromatin	activating transcription factor binding|chromatin binding|DNA secondary structure binding|RNA polymerase II transcription coactivator activity			breast(1)	1				GBM - Glioblastoma multiforme(50;2.38e-06)		TGATGCATTTGATTGTTTAGT	0.284			NA											18	82					0	0	0.006122	0	0
BNC2	54796	broad.mit.edu	37	9	16437286	16437286	+	Silent	SNP	C	C	T			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr9:16437286C>T	uc003zml.2	-	6	1046	c.906G>A	c.(904-906)GAG>GAA	p.E302E	BNC2_uc011lmw.1_Silent_p.E207E|BNC2_uc003zmm.2_Silent_p.E260E|BNC2_uc003zmq.1_Silent_p.E316E|BNC2_uc003zmr.1_Silent_p.E339E|BNC2_uc003zmp.1_Silent_p.E330E|BNC2_uc010mij.1_Silent_p.E224E|BNC2_uc011lmv.1_Silent_p.E128E|BNC2_uc003zmo.1_Silent_p.E224E|BNC2_uc003zmj.2_Silent_p.E67E|BNC2_uc003zmk.2_RNA|BNC2_uc003zmi.2_Silent_p.E67E|BNC2_uc003zmn.1_Silent_p.E67E	NM_017637	NP_060107	Q6ZN30	BNC2_HUMAN	basonuclin 2	302					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	zinc ion binding			ovary(2)|central_nervous_system(1)	3				GBM - Glioblastoma multiforme(50;9.01e-08)		GATTGCTGTTCTCTAAGTGAG	0.473			NA											12	195					0	0	0.00245	0	0
TOPORS	10210	broad.mit.edu	37	9	32543115	32543115	+	Missense_Mutation	SNP	C	C	G			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr9:32543115C>G	uc003zrb.2	-	3	1575	c.1408G>C	c.(1408-1410)GAC>CAC	p.D470H	TOPORS_uc003zrc.2_Missense_Mutation_p.D403H	NM_005802	NP_005793	Q9NS56	TOPRS_HUMAN	topoisomerase I binding, arginine/serine-rich	470	Interaction with p53/TP53.|Required for sumoylation and localization to discrete nuclear foci.|Interaction with SUMO1.|Interaction with TOP1.				DNA damage response, signal transduction resulting in induction of apoptosis|maintenance of protein location in nucleus|proteasomal ubiquitin-dependent protein catabolic process|protein sumoylation|transcription, DNA-dependent	nuclear speck|PML body	antigen binding|DNA binding|DNA topoisomerase I binding|SUMO ligase activity|ubiquitin-protein ligase activity|zinc ion binding			ovary(3)|upper_aerodigestive_tract(1)|skin(1)	5			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.0018)		TCATCACTGTCATTATTTAGG	0.408			NA											9	106					0	0	0.006214	0	0
UBAP1	51271	broad.mit.edu	37	9	34242054	34242054	+	Missense_Mutation	SNP	C	C	G			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr9:34242054C>G	uc003ztx.2	+	4	1266	c.1031C>G	c.(1030-1032)TCT>TGT	p.S344C	UBAP1_uc010mka.1_Missense_Mutation_p.S380C|UBAP1_uc003zty.2_Missense_Mutation_p.S344C|UBAP1_uc011loi.1_Missense_Mutation_p.S380C|UBAP1_uc011loj.1_Missense_Mutation_p.S408C|KIF24_uc010mkb.2_Intron|UBAP1_uc003ztz.2_Missense_Mutation_p.S344C	NM_016525	NP_057609	Q9NZ09	UBAP1_HUMAN	ubiquitin associated protein 1	344						cytoplasm					0			LUSC - Lung squamous cell carcinoma(29;0.00272)			CCTTCCCTCTCTGTTTTGTCT	0.507	NSCLC(109;1074 1634 14978 20375 39620)		NA											5	158					0	0	0.001984	0	0
RUSC2	9853	broad.mit.edu	37	9	35561270	35561270	+	Missense_Mutation	SNP	G	G	C			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr9:35561270G>C	uc003zww.2	+	12	4697	c.4442G>C	c.(4441-4443)GGA>GCA	p.G1481A	RUSC2_uc010mkq.2_RNA|RUSC2_uc003zwx.3_Missense_Mutation_p.G1481A	NM_014806	NP_055621	Q8N2Y8	RUSC2_HUMAN	RUN and SH3 domain containing 2	1481	SH3.					cytosol				ovary(1)	1			Lung(28;0.000837)|LUSC - Lung squamous cell carcinoma(32;0.00109)|STAD - Stomach adenocarcinoma(86;0.194)			GGGCGAGCTGGAGGAGACTGG	0.652			NA											3	49					0	0	0.004672	0	0
TLN1	7094	broad.mit.edu	37	9	35707217	35707217	+	Missense_Mutation	SNP	C	C	T			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr9:35707217C>T	uc003zxt.2	-	37	5161	c.4807G>A	c.(4807-4809)GCC>ACC	p.A1603T		NM_006289	NP_006280	Q9Y490	TLN1_HUMAN	talin 1	1603	Interaction with SYNM.				axon guidance|cell adhesion|cell-cell junction assembly|cellular component movement|cytoskeletal anchoring at plasma membrane|muscle contraction|platelet activation|platelet degranulation	actin cytoskeleton|centrosome|cytosol|extracellular region|focal adhesion|intracellular membrane-bounded organelle|ruffle membrane	actin binding|insulin receptor binding|LIM domain binding|structural constituent of cytoskeleton|vinculin binding			lung(7)|breast(3)|ovary(2)|central_nervous_system(1)	13	all_epithelial(49;0.167)		Lung(28;0.00276)|LUSC - Lung squamous cell carcinoma(32;0.00418)|STAD - Stomach adenocarcinoma(86;0.194)			ATTGTCTTGGCAGAGATCACA	0.642			NA											34	26					0	0	0.006999	0	0
NPR2	4882	broad.mit.edu	37	9	35794089	35794089	+	Missense_Mutation	SNP	G	G	C			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr9:35794089G>C	uc003zyd.2	+	2	862	c.862G>C	c.(862-864)GAG>CAG	p.E288Q	NPR2_uc010mlb.2_Missense_Mutation_p.E288Q	NM_003995	NP_003986	P20594	ANPRB_HUMAN	natriuretic peptide receptor B precursor	288	Extracellular (Potential).				intracellular signal transduction|ossification|receptor guanylyl cyclase signaling pathway|regulation of blood pressure	integral to membrane|plasma membrane	GTP binding|guanylate cyclase activity|natriuretic peptide receptor activity|protein kinase activity|transmembrane receptor activity			ovary(2)|stomach(1)	3	all_epithelial(49;0.161)		LUSC - Lung squamous cell carcinoma(32;0.00521)|Lung(28;0.00697)|STAD - Stomach adenocarcinoma(86;0.194)		Erythrityl Tetranitrate(DB01613)|Nesiritide(DB04899)	ggccctcagagaggcctttca	0.388			NA											3	40					0	0	0.004672	0	0
GNAQ	2776	broad.mit.edu	37	9	80430572	80430572	+	Missense_Mutation	SNP	C	C	G			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr9:80430572C>G	uc004akw.2	-	3	477	c.436G>C	c.(436-438)GAT>CAT	p.D146H	GNAQ_uc011lso.1_5'UTR	NM_002072	NP_002063	P50148	GNAQ_HUMAN	guanine nucleotide binding protein (G protein),	146					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity by dopamine receptor signaling pathway|glutamate signaling pathway|negative regulation of protein kinase activity|platelet activation|protein ADP-ribosylation|protein stabilization|regulation of action potential|regulation of catenin import into nucleus	cytoplasm|heterotrimeric G-protein complex	G-protein beta/gamma-subunit complex binding|G-protein-coupled receptor binding|GTP binding|GTPase activator activity|GTPase activity|signal transducer activity			eye(136)|skin(44)|meninges(11)|ovary(1)|kidney(1)	193						CGTCGTCTATCATAGCATTCC	0.388			NA	Mis		uveal melanoma								3	49					0	0	0.009096	0	0
TGFBR1	7046	broad.mit.edu	37	9	101908883	101908883	+	Missense_Mutation	SNP	C	C	T			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr9:101908883C>T	uc004azc.2	+	7	1323	c.1247C>T	c.(1246-1248)TCC>TTC	p.S416F	TGFBR1_uc004azd.2_Missense_Mutation_p.S339F|TGFBR1_uc011lvc.1_Missense_Mutation_p.S347F	NM_004612	NP_004603	P36897	TGFR1_HUMAN	transforming growth factor, beta receptor I	416	Protein kinase.|Cytoplasmic (Potential).				activation of MAPKK activity|anterior/posterior pattern formation|artery morphogenesis|collagen fibril organization|embryonic cranial skeleton morphogenesis|germ cell migration|heart development|kidney development|neuron fate commitment|palate development|parathyroid gland development|pathway-restricted SMAD protein phosphorylation|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|pharyngeal system development|positive regulation of cell growth|positive regulation of cell proliferation|positive regulation of cellular component movement|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of protein kinase B signaling cascade|positive regulation of SMAD protein import into nucleus|positive regulation of survival gene product expression|positive regulation of transcription, DNA-dependent|response to cholesterol|thymus development|transforming growth factor beta receptor signaling pathway		ATP binding|I-SMAD binding|metal ion binding|transforming growth factor beta binding|transforming growth factor beta receptor activity, type I|type II transforming growth factor beta receptor binding			lung(2)|ovary(1)	3		Acute lymphoblastic leukemia(62;0.0559)				CGACGATGTTCCATTGGTGGT	0.373			NA											12	376					0	0	0.003163	0	0
PPP3R2	5535	broad.mit.edu	37	9	104357089	104357090	+	Missense_Mutation	DNP	TC	TC	AT			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	TC	TC	-	-	TC	TC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr9:104357089_104357090TC>AT	uc004bbr.2	-	1	194_195	c.123_124GA>AT	c.(121-126)CTGAGC>CTATGC	p.S42C	GRIN3A_uc004bbp.1_Intron|GRIN3A_uc004bbq.1_Intron|PPP3R2_uc010mtf.1_Intron	NM_147180	NP_671709	Q96LZ3	CANB2_HUMAN	protein phosphatase 3 regulatory subunit B, beta	39	EF-hand 1.|1.						calcium ion binding			ovary(1)|skin(1)	2		Acute lymphoblastic leukemia(62;0.0527)			Cyclosporine(DB00091)	TCCTCCACGCTCAGAGACCCTG	0.55			NA											63	98					0	0	0.004672	0	0
OR13C8	138802	broad.mit.edu	37	9	107332060	107332060	+	Silent	SNP	G	G	C			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr9:107332060G>C	uc011lvo.1	+	1	612	c.612G>C	c.(610-612)CTG>CTC	p.L204L		NM_001004483	NP_001004483	Q8NGS7	O13C8_HUMAN	olfactory receptor, family 13, subfamily C,	204	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						GGTCGAATCTGATTGTTCTGG	0.353			NA											6	204					0	0	0.001984	0	0
OR13C8	138802	broad.mit.edu	37	9	107332126	107332126	+	Silent	SNP	G	G	A			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr9:107332126G>A	uc011lvo.1	+	1	678	c.678G>A	c.(676-678)CTG>CTA	p.L226L		NM_001004483	NP_001004483	Q8NGS7	O13C8_HUMAN	olfactory receptor, family 13, subfamily C,	226	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						CCACTATTCTGAGGATTCCTT	0.398			NA											7	142					0	0	0.001984	0	0
OR13C8	138802	broad.mit.edu	37	9	107332309	107332309	+	Missense_Mutation	SNP	G	G	A			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr9:107332309G>A	uc011lvo.1	+	1	861	c.861G>A	c.(859-861)ATG>ATA	p.M287I		NM_001004483	NP_001004483	Q8NGS7	O13C8_HUMAN	olfactory receptor, family 13, subfamily C,	287	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						ATGGAGTGATGACTCCCATGC	0.413			NA											7	100					0	0	0.00308	0	0
OR13C9	286362	broad.mit.edu	37	9	107379953	107379953	+	Missense_Mutation	SNP	G	G	A			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr9:107379953G>A	uc011lvr.1	-	1	533	c.533C>T	c.(532-534)TCA>TTA	p.S178L		NM_001001956	NP_001001956	Q8NGT0	O13C9_HUMAN	olfactory receptor, family 13, subfamily C,	178	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						AATTTCACATGAGAAATGATT	0.438			NA											5	141					0	0	0.000602	0	0
EPB41L4B	54566	broad.mit.edu	37	9	112015721	112015721	+	Missense_Mutation	SNP	C	C	G			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr9:112015721C>G	uc004bdz.1	-	12	1574	c.1279G>C	c.(1279-1281)GCA>CCA	p.A427P	EPB41L4B_uc004bea.2_Missense_Mutation_p.A427P	NM_019114	NP_061987	Q9H329	E41LB_HUMAN	erythrocyte membrane protein band 4.1 like 4B	427						cytoplasm|cytoskeleton|extrinsic to membrane	cytoskeletal protein binding|structural constituent of cytoskeleton			ovary(1)|central_nervous_system(1)|skin(1)	3						AACACACAACCTTTGAACGTT	0.428			NA											18	111					0	0	0.008871	0	0
LMX1B	4010	broad.mit.edu	37	9	129453345	129453345	+	Missense_Mutation	SNP	C	C	G			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr9:129453345C>G	uc004bqj.2	+	3	538	c.488C>G	c.(487-489)TCC>TGC	p.S163C	LMX1B_uc004bqi.2_Missense_Mutation_p.S163C|LMX1B_uc011maa.1_Missense_Mutation_p.S163C	NM_002316	NP_002307	O60663	LMX1B_HUMAN	LIM homeobox transcription factor 1, beta	163					dorsal/ventral pattern formation|in utero embryonic development	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0						GAGTCCGACTCCGGTGAGGCC	0.667	Pancreas(110;1796 2278 18357 20466)		NA							Nail-Patella_Syndrome				4	23					0	0	0.009096	0	0
NOTCH1	4851	broad.mit.edu	37	9	139400074	139400074	+	Missense_Mutation	SNP	C	C	A			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr9:139400074C>A	uc004chz.2	-	25	4274	c.4274G>T	c.(4273-4275)TGC>TTC	p.C1425F	NOTCH1_uc004cia.1_Missense_Mutation_p.C655F	NM_017617	NP_060087	P46531	NOTC1_HUMAN	notch1 preproprotein	1425	Extracellular (Potential).|EGF-like 36.				aortic valve morphogenesis|immune response|negative regulation of BMP signaling pathway|negative regulation of cell-substrate adhesion|negative regulation of myoblast differentiation|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-dependent|Notch receptor processing	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			haematopoietic_and_lymphoid_tissue(791)|upper_aerodigestive_tract(29)|lung(13)|central_nervous_system(10)|breast(9)|large_intestine(1)|skin(1)|oesophagus(1)|pancreas(1)	856	all_cancers(76;0.223)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.34e-06)|Epithelial(140;7.77e-06)		CAGGATGTGGCACAAGAGCCC	0.682			NA	T|Mis|O	TRB@	T-ALL					HNSCC(8;0.001)			9	21					1.58986e-06	1.85102e-06	0.008291	1	0
PHKA2	5256	broad.mit.edu	37	X	18924680	18924680	+	Silent	SNP	C	C	G			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chrX:18924680C>G	uc004cyv.3	-	25	3169	c.2739G>C	c.(2737-2739)CTG>CTC	p.L913L	PHKA2_uc004cyu.3_Silent_p.L211L|PHKA2_uc010nfe.1_5'Flank|PHKA2_uc010nff.1_5'Flank	NM_000292	NP_000283	P46019	KPB2_HUMAN	phosphorylase kinase, alpha 2 (liver)	913					glucose metabolic process|glycogen catabolic process	cytosol|phosphorylase kinase complex|plasma membrane	calmodulin binding|glucan 1,4-alpha-glucosidase activity|phosphorylase kinase activity			ovary(1)|central_nervous_system(1)	2	Hepatocellular(33;0.183)					TCCGGAGTCTCAGCATCTCCA	0.587			NA											3	91					0	0	0.004672	0	0
CXorf22	170063	broad.mit.edu	37	X	35988982	35988982	+	Missense_Mutation	SNP	T	T	C			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chrX:35988982T>C	uc004ddj.2	+	11	1971	c.1912T>C	c.(1912-1914)TAT>CAT	p.Y638H	CXorf22_uc010ngv.2_RNA	NM_152632	NP_689845	Q6ZTR5	CX022_HUMAN	hypothetical protein LOC170063	638										large_intestine(1)|lung(1)|ovary(1)	3						TGAAAACTATTATGCAATGTA	0.318			NA											9	2					0	0	0.010729	0	0
DCAF12L2	340578	broad.mit.edu	37	X	125299513	125299513	+	Missense_Mutation	SNP	C	C	A			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chrX:125299513C>A	uc004euk.1	-	1	422	c.395G>T	c.(394-396)CGC>CTC	p.R132L		NM_001013628	NP_001013650	Q5VW00	DC122_HUMAN	DDB1 and CUL4 associated factor 12-like 2	132										lung(2)|skin(2)|large_intestine(1)|pancreas(1)|ovary(1)	7						GAGGGGGATGCGCGTGATGTG	0.637			NA											4	90					0.00116845	0.00132227	0.001168	1	0
DCAF12L1	139170	broad.mit.edu	37	X	125685236	125685236	+	Silent	SNP	T	T	G			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chrX:125685236T>G	uc004eul.2	-	1	1607	c.1356A>C	c.(1354-1356)GCA>GCC	p.A452A		NM_178470	NP_848565	Q5VU92	DC121_HUMAN	DDB1 and CUL4 associated factor 12-like 1	452										skin(3)|ovary(1)	4						CATGGAGGCCTGCAGGGAGAG	0.547			NA											4	65					0	0	0.000602	0	0
LDOC1	23641	broad.mit.edu	37	X	140270933	140270933	+	Silent	SNP	G	G	A			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chrX:140270933G>A	uc004fbj.2	-	1	378	c.274C>T	c.(274-276)CTA>TTA	p.L92L		NM_012317	NP_036449	O95751	LDOC1_HUMAN	leucine zipper, down-regulated in cancer 1	92					negative regulation of cell proliferation	nucleus	protein binding				0	Acute lymphoblastic leukemia(192;7.65e-05)					AGGCTGATTAGGAATGCCACC	0.582			NA											4	109					0	0	0.001168	0	0
HCFC1	3054	broad.mit.edu	37	X	153223608	153223608	+	Silent	SNP	G	G	A			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chrX:153223608G>A	uc004fjp.2	-	11	2424	c.1896C>T	c.(1894-1896)ATC>ATT	p.I632I		NM_005334	NP_005325	P51610	HCFC1_HUMAN	host cell factor 1	632	Interaction with SIN3A.				cell cycle|interspecies interaction between organisms|positive regulation of cell cycle|positive regulation of gene expression|protein stabilization|reactivation of latent virus|regulation of protein complex assembly|transcription from RNA polymerase II promoter	mitochondrion|MLL1 complex|MLL5-L complex|Set1C/COMPASS complex	chromatin binding|identical protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			ovary(2)	2	all_cancers(53;6.23e-16)|all_epithelial(53;5.61e-10)|all_lung(58;3.99e-07)|Lung NSC(58;5.02e-07)|all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					GCACTGTGATGATAGGGCGGG	0.612			NA											7	30					0	0	0.008291	0	0
UTY	7404	broad.mit.edu	37	Y	15372253	15372253	+	Nonsense_Mutation	SNP	G	G	A			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chrY:15372253G>A	uc004fsx.1	-	26	4756	c.3751C>T	c.(3751-3753)CAG>TAG	p.Q1251*	UTY_uc004fsw.1_Nonsense_Mutation_p.Q914*|UTY_uc010nwx.1_Nonsense_Mutation_p.Q308*	NM_007125	NP_009056	O14607	UTY_HUMAN	tetratricopeptide repeat protein isoform 3	1251					chromatin modification	nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen				0						CTCAATGTCTGATATTGCTTC	0.363	Colon(103;1740 2135 40732 45171)		NA											11	54					0	0	0.010729	0	0
SYT11	23208	broad.mit.edu	37	1	155851017	155851018	+	Frame_Shift_Del	DEL	CG	CG	-			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	CG	CG	-	-	CG	CG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr1:155851017_155851018delCG	uc001fmg.2	+	4	1277_1278	c.1014_1015delCG	c.(1012-1017)TACGGCfs	p.Y338fs	SYT11_uc010pgq.1_Frame_Shift_Del_p.Y31fs	NM_152280	NP_689493	Q9BT88	SYT11_HUMAN	synaptotagmin XI	338_339	C2 2.|Cytoplasmic (Potential).					cell junction|synaptic vesicle membrane	protein binding|transporter activity			ovary(1)|skin(1)	2	Hepatocellular(266;0.133)|all_hematologic(923;0.145)|all_neural(408;0.195)		OV - Ovarian serous cystadenocarcinoma(3;0.000162)			ACGTCTACTACGGCAGAAAGCG	0.455			NA											10	765	---	---	---	---	NA	NA	NA	NA	NA
NES	10763	broad.mit.edu	37	1	156646400	156646403	+	Frame_Shift_Del	DEL	GCGG	GCGG	-			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	GCGG	GCGG	-	-	GCGG	GCGG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr1:156646400_156646403delGCGG	uc001fpq.2	-	1	787_790	c.654_657delCCGC	c.(652-657)GCCCGCfs	p.A218fs		NM_006617	NP_006608	P48681	NEST_HUMAN	nestin	218_219	Coil 2B.|Rod.				brain development|embryonic camera-type eye development|G2/M transition of mitotic cell cycle|negative regulation of apoptosis|positive regulation of intermediate filament depolymerization|positive regulation of neural precursor cell proliferation|stem cell proliferation	cytoplasm|intermediate filament	intermediate filament binding|structural molecule activity			ovary(6)	6	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					GGCGGCCCTCGCGGGCACCCTGCA	0.755			NA											6	12	---	---	---	---	NA	NA	NA	NA	NA
POLR2C	5432	broad.mit.edu	37	16	57503120	57503121	+	Frame_Shift_Ins	INS	-	-	A			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr16:57503120_57503121insA	uc002elt.1	+	5	388_389	c.302_303insA	c.(301-303)TTCfs	p.F101fs	POLR2C_uc010vhq.1_Frame_Shift_Ins_p.F101fs	NM_032940	NP_116558	P19387	RPB3_HUMAN	DNA directed RNA polymerase II polypeptide C	101					mRNA capping|nuclear mRNA splicing, via spliceosome|positive regulation of viral transcription|protein phosphorylation|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	DNA-directed RNA polymerase II, core complex	DNA binding|DNA-directed RNA polymerase activity|protein dimerization activity				0						TCGGTGGAGTTCACCCTCGATG	0.589			NA											42	104	---	---	---	---	NA	NA	NA	NA	NA
DOT1L	84444	broad.mit.edu	37	19	2210737	2210737	+	Frame_Shift_Del	DEL	G	G	-			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr19:2210737delG	uc002lvb.3	+	14	1270	c.1234delG	c.(1234-1236)GGGfs	p.G412fs	DOT1L_uc002lvc.1_5'Flank	NM_032482	NP_115871	Q8TEK3	DOT1L_HUMAN	DOT1-like, histone H3 methyltransferase	412	Required for interaction with nucleosomes and DNA.					nucleus	DNA binding|histone-lysine N-methyltransferase activity|protein binding			pancreas(2)|upper_aerodigestive_tract(1)|lung(1)	4		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CCGCAAGCGCGGGCGCCCCAA	0.607			NA											16	113	---	---	---	---	NA	NA	NA	NA	NA
SIGLEC5	8778	broad.mit.edu	37	19	52130914	52130914	+	Frame_Shift_Del	DEL	G	G	-			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr19:52130914delG	uc002pxe.2	-	6	1222	c.1083delC	c.(1081-1083)CCCfs	p.P361fs		NM_003830	NP_003821	O15389	SIGL5_HUMAN	sialic acid binding Ig-like lectin 5 precursor	361	Extracellular (Potential).				cell adhesion	integral to membrane	sugar binding			skin(2)|breast(1)|central_nervous_system(1)	4		all_neural(266;0.0726)		GBM - Glioblastoma multiforme(134;0.00124)|OV - Ovarian serous cystadenocarcinoma(262;0.0218)		AGCACAGGGAGGGGGCCGGCC	0.677			NA											10	15	---	---	---	---	NA	NA	NA	NA	NA
SH3D19	152503	broad.mit.edu	37	4	152096011	152096011	+	Frame_Shift_Del	DEL	G	G	-			TCGA-49-4486-01A-01D-1265-08	TCGA-49-4486-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ac132c3-4889-4dc3-8b3d-0ef98065a858	ee2aab05-2f1d-406d-834c-f1b011b7b6eb	g.chr4:152096011delG	uc010ipl.1	-	7	1595	c.505delC	c.(505-507)CGAfs	p.R169fs	SH3D19_uc003imc.2_Frame_Shift_Del_p.R169fs|SH3D19_uc003ime.2_Frame_Shift_Del_p.R169fs|SH3D19_uc010ipm.2_Frame_Shift_Del_p.R169fs	NM_001009555	NP_001009555	Q5HYK7	SH319_HUMAN	SH3 domain containing 19 isoform a	169	Pro-rich.				cellular membrane organization|positive regulation of membrane protein ectodomain proteolysis|post-Golgi vesicle-mediated transport	cytosol|Golgi apparatus|nucleus|plasma membrane	proline-rich region binding			ovary(1)|skin(1)	2	all_hematologic(180;0.093)	Acute lymphoblastic leukemia(8;0.138)				CCTGCGAGTCGGGGAGGAACA	0.582			NA											179	321	---	---	---	---	NA	NA	NA	NA	NA