Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	ACHILLES_Top_Genes	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
GPN2	54707	broad.mit.edu	37	1	27216290	27216290	+	Missense_Mutation	SNP	C	C	T			TCGA-44-2665-01A-01D-1040-01	TCGA-44-2665-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	520db804-4c03-4a0c-9966-fc0c9f98cfec	4b84f6af-2361-4e9b-9c8c-f1cbeb8513f2	g.chr1:27216290C>T	uc001bnd.1	-	1	580	c.298G>A	c.(298-300)GAC>AAC	p.D100N		NM_018066	NP_060536	Q9H9Y4	GPN2_HUMAN	ATP binding domain 1 family, member B	100							GTP binding				0						CGGAGGGGGTCGAGCTTGGCA	0.667			NA											16	68					0	0	0.028581	0	0
KIAA1522	57648	broad.mit.edu	37	1	33237497	33237497	+	Missense_Mutation	SNP	C	C	T			TCGA-44-2665-01A-01D-1040-01	TCGA-44-2665-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	520db804-4c03-4a0c-9966-fc0c9f98cfec	4b84f6af-2361-4e9b-9c8c-f1cbeb8513f2	g.chr1:33237497C>T	uc001bvv.2	+	6	2676	c.2540C>T	c.(2539-2541)TCG>TTG	p.S847L	KIAA1522_uc001bvu.1_Missense_Mutation_p.S906L|KIAA1522_uc010ohm.1_Missense_Mutation_p.S858L|KIAA1522_uc010ohn.1_Intron	NM_020888	NP_065939	Q9P206	K1522_HUMAN	hypothetical protein LOC57648	847	Pro-rich.										0		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Breast(348;0.244)				CTGGGGCCATCGGCCCCCCAG	0.721			NA											8	15					0	0	0.047766	0	0
CSF1	1435	broad.mit.edu	37	1	110465931	110465931	+	Missense_Mutation	SNP	G	G	A			TCGA-44-2665-01A-01D-1040-01	TCGA-44-2665-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	520db804-4c03-4a0c-9966-fc0c9f98cfec	4b84f6af-2361-4e9b-9c8c-f1cbeb8513f2	g.chr1:110465931G>A	uc001dyu.2	+	6	1101	c.688G>A	c.(688-690)GAG>AAG	p.E230K	CSF1_uc001dyt.2_Missense_Mutation_p.E230K|CSF1_uc001dyv.3_Intron|CSF1_uc001dyw.3_Missense_Mutation_p.E230K	NM_172212	NP_757351	P09603	CSF1_HUMAN	colony stimulating factor 1 isoform a precursor	230	Lumenal (Potential).				cell proliferation|developmental process involved in reproduction|macrophage differentiation|monocyte activation|osteoclast differentiation|positive regulation of cell migration|positive regulation of cell-matrix adhesion|positive regulation of cellular protein metabolic process|positive regulation of gene expression|positive regulation of macrophage derived foam cell differentiation|positive regulation of macrophage differentiation|positive regulation of monocyte differentiation|positive regulation of mononuclear cell proliferation|positive regulation of protein kinase activity	extracellular space|integral to membrane|perinuclear region of cytoplasm|plasma membrane|receptor complex	cytokine activity|growth factor activity|macrophage colony-stimulating factor receptor binding|protein homodimerization activity			ovary(1)	1		all_epithelial(167;3.58e-05)|all_lung(203;0.000116)|Lung NSC(277;0.000233)|Acute lymphoblastic leukemia(138;0.204)		Lung(183;0.0238)|Colorectal(144;0.112)|all cancers(265;0.117)|Epithelial(280;0.127)|LUSC - Lung squamous cell carcinoma(189;0.135)		TGAGGGAACTGAGGGCAGCTC	0.662			NA									OREG0013645	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	14	49					0	0	0.016723	0	0
AMPD1	270	broad.mit.edu	37	1	115222965	115222965	+	Missense_Mutation	SNP	C	C	T			TCGA-44-2665-01A-01D-1040-01	TCGA-44-2665-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	520db804-4c03-4a0c-9966-fc0c9f98cfec	4b84f6af-2361-4e9b-9c8c-f1cbeb8513f2	g.chr1:115222965C>T	uc001efe.1	-	6	766	c.682G>A	c.(682-684)GAG>AAG	p.E228K	AMPD1_uc001eff.1_Missense_Mutation_p.E224K	NM_000036	NP_000027	P23109	AMPD1_HUMAN	adenosine monophosphate deaminase 1 (isoform M)	228					purine base metabolic process|purine ribonucleoside monophosphate biosynthetic process|purine-containing compound salvage	cytosol	AMP deaminase activity|metal ion binding			ovary(2)|large_intestine(1)|skin(1)	4	all_epithelial(7;7.83e-05)|all_lung(7;0.000179)|Lung NSC(6;0.00195)|Lung SC(450;0.211)	all_cancers(81;4.64e-07)|all_epithelial(167;4.2e-07)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)	Adenosine monophosphate(DB00131)	GGCTTAGGCTCATCTTTGCTG	0.423			NA											4	53					0	0	0.009096	0	0
AQP10	89872	broad.mit.edu	37	1	154296116	154296116	+	Missense_Mutation	SNP	C	C	T			TCGA-44-2665-01A-01D-1040-01	TCGA-44-2665-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	520db804-4c03-4a0c-9966-fc0c9f98cfec	4b84f6af-2361-4e9b-9c8c-f1cbeb8513f2	g.chr1:154296116C>T	uc001feu.2	+	5	581	c.541C>T	c.(541-543)CGG>TGG	p.R181W	AQP10_uc001fev.2_Missense_Mutation_p.R181W|ATP8B2_uc001few.2_5'Flank	NM_080429	NP_536354	Q96PS8	AQP10_HUMAN	aquaporin 10	181	Cytoplasmic (Potential).				response to toxin|transmembrane transport|water transport	integral to membrane|plasma membrane	transporter activity			central_nervous_system(1)	1	all_lung(78;2.62e-30)|Lung NSC(65;3.94e-28)|Hepatocellular(266;0.0877)		LUSC - Lung squamous cell carcinoma(543;0.185)			CCTGGACAGACGGAACAAGGG	0.612			NA											31	277					0	0	0.041601	0	0
DDR2	4921	broad.mit.edu	37	1	162740301	162740301	+	Silent	SNP	A	A	G			TCGA-44-2665-01A-01D-1040-01	TCGA-44-2665-10A-01D-1040-01	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	520db804-4c03-4a0c-9966-fc0c9f98cfec	4b84f6af-2361-4e9b-9c8c-f1cbeb8513f2	g.chr1:162740301A>G	uc001gcf.2	+	13	1968	c.1503A>G	c.(1501-1503)TCA>TCG	p.S501S	DDR2_uc001gcg.2_Silent_p.S501S	NM_001014796	NP_001014796	Q16832	DDR2_HUMAN	discoidin domain receptor family, member 2	501	Cytoplasmic (Potential).				cell adhesion	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(2)|central_nervous_system(2)|ovary(1)|kidney(1)	6	all_hematologic(112;0.115)		BRCA - Breast invasive adenocarcinoma(70;0.113)			AGGAGGAGTCAGGTGAGGATG	0.527	NSCLC(161;314 2006 8283 19651 23192)		NA											5	26					0	0	0.014758	0	0
C1orf58	148362	broad.mit.edu	37	1	222900585	222900585	+	Missense_Mutation	SNP	T	T	C			TCGA-44-2665-01A-01D-1040-01	TCGA-44-2665-10A-01D-1040-01	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	520db804-4c03-4a0c-9966-fc0c9f98cfec	4b84f6af-2361-4e9b-9c8c-f1cbeb8513f2	g.chr1:222900585T>C	uc001hnq.1	+	8	1051	c.656T>C	c.(655-657)TTC>TCC	p.F219S	C1orf58_uc010put.1_Missense_Mutation_p.F187S|C1orf58_uc010puu.1_Missense_Mutation_p.F219S|C1orf58_uc010puv.1_Missense_Mutation_p.F187S|uc001hnr.1_RNA	NM_144695	NP_653296	Q5VW32	BROX_HUMAN	Bro1-domain-containing protein	219	BRO1.					membrane					0				GBM - Glioblastoma multiforme(131;0.0667)		ACAGCCAATTTCTATCAAAAA	0.343			NA											10	42					0	0	0.010729	0	0
OR14A16	284532	broad.mit.edu	37	1	247978972	247978972	+	Missense_Mutation	SNP	A	A	C			TCGA-44-2665-01A-01D-1040-01	TCGA-44-2665-10A-01D-1040-01	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	520db804-4c03-4a0c-9966-fc0c9f98cfec	4b84f6af-2361-4e9b-9c8c-f1cbeb8513f2	g.chr1:247978972A>C	uc001idm.1	-	1	60	c.60T>G	c.(58-60)AAT>AAG	p.N20K		NM_001001966	NP_001001966	Q8NHC5	O14AG_HUMAN	olfactory receptor, family 14, subfamily A,	20	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						AAATGCACATATTTTTATTGG	0.383	Ovarian(112;180 1586 15073 21914 33526)		NA											8	18					0	0	0.010729	0	0
SVIL	6840	broad.mit.edu	37	10	29819539	29819539	+	Silent	SNP	G	G	A			TCGA-44-2665-01A-01D-1040-01	TCGA-44-2665-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	520db804-4c03-4a0c-9966-fc0c9f98cfec	4b84f6af-2361-4e9b-9c8c-f1cbeb8513f2	g.chr10:29819539G>A	uc001iut.1	-	11	2856	c.2103C>T	c.(2101-2103)TTC>TTT	p.F701F	SVIL_uc001iuu.1_Silent_p.F307F	NM_021738	NP_068506	O95425	SVIL_HUMAN	supervillin isoform 2	701					cytoskeleton organization|skeletal muscle tissue development	cell junction|costamere|invadopodium|nucleus|podosome	actin filament binding			ovary(5)|upper_aerodigestive_tract(1)	6		Breast(68;0.103)				AGCTTACCCTGAAAAGCAACC	0.348			NA											16	73					0	0	0.0333	0	0
AMPD3	272	broad.mit.edu	37	11	10500113	10500113	+	Silent	SNP	C	C	T			TCGA-44-2665-01A-01D-1040-01	TCGA-44-2665-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	520db804-4c03-4a0c-9966-fc0c9f98cfec	4b84f6af-2361-4e9b-9c8c-f1cbeb8513f2	g.chr11:10500113C>T	uc001mio.1	+	3	597	c.262C>T	c.(262-264)CTG>TTG	p.L88L	AMPD3_uc010rbz.1_Intron|AMPD3_uc001min.1_Silent_p.L97L|AMPD3_uc009yfw.1_RNA|AMPD3_uc009yfx.1_Silent_p.L88L|AMPD3_uc009yfz.2_RNA|AMPD3_uc001mip.1_Silent_p.L95L|AMPD3_uc009yfy.2_Silent_p.L88L	NM_001025389	NP_001020560	Q01432	AMPD3_HUMAN	adenosine monophosphate deaminase 3 isoform 1B	88					AMP catabolic process|purine base metabolic process|purine ribonucleoside monophosphate biosynthetic process|purine-containing compound salvage	cytosol	AMP deaminase activity|metal ion binding			large_intestine(1)|ovary(1)	2				all cancers(16;1.14e-08)|Epithelial(150;2.83e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0291)		GTCCCTGTCTCTGCAAATGCC	0.547			NA											11	234					0	0	0.010729	0	0
KAT5	10524	broad.mit.edu	37	11	65482336	65482336	+	Silent	SNP	C	C	G			TCGA-44-2665-01A-01D-1040-01	TCGA-44-2665-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	520db804-4c03-4a0c-9966-fc0c9f98cfec	4b84f6af-2361-4e9b-9c8c-f1cbeb8513f2	g.chr11:65482336C>G	uc001ofi.2	+	9	1135	c.885C>G	c.(883-885)CGC>CGG	p.R295R	KAT5_uc001ofj.2_Silent_p.R243R|KAT5_uc001ofk.2_Silent_p.R328R|KAT5_uc010roo.1_Silent_p.R276R|KAT5_uc001ofl.2_Silent_p.R84R	NM_006388	NP_006379	Q92993	KAT5_HUMAN	K(lysine) acetyltransferase 5 isoform 2	295					androgen receptor signaling pathway|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|double-strand break repair|interspecies interaction between organisms|negative regulation of interleukin-2 production|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|regulation of growth|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nucleolus|perinuclear region of cytoplasm|Piccolo NuA4 histone acetyltransferase complex	androgen receptor binding|histone acetyltransferase activity|metal ion binding|repressing transcription factor binding|transcription coactivator activity				0						AGATTTACCGCAAGGGCACCA	0.522			NA											26	66					0	0	0.027356	0	0
C11orf63	79864	broad.mit.edu	37	11	122774779	122774779	+	Missense_Mutation	SNP	A	A	G	rs147035469	byFrequency	TCGA-44-2665-01A-01D-1040-01	TCGA-44-2665-10A-01D-1040-01	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	520db804-4c03-4a0c-9966-fc0c9f98cfec	4b84f6af-2361-4e9b-9c8c-f1cbeb8513f2	g.chr11:122774779A>G	uc001pym.2	+	3	788	c.491A>G	c.(490-492)TAC>TGC	p.Y164C	C11orf63_uc001pyl.1_Missense_Mutation_p.Y164C	NM_024806	NP_079082	Q6NUN7	CK063_HUMAN	hypothetical protein LOC79864 isoform 1	164										ovary(3)	3		Breast(109;0.00249)|Lung NSC(97;0.0177)|all_lung(97;0.018)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;5.34e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0311)		GCTCCCCTCTACCCTTCCCAG	0.517			NA											15	61					0	0	0.020292	0	0
KRT73	319101	broad.mit.edu	37	12	53012246	53012246	+	Silent	SNP	G	G	A			TCGA-44-2665-01A-01D-1040-01	TCGA-44-2665-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	520db804-4c03-4a0c-9966-fc0c9f98cfec	4b84f6af-2361-4e9b-9c8c-f1cbeb8513f2	g.chr12:53012246G>A	uc001sas.2	-	1	98	c.63C>T	c.(61-63)TCC>TCT	p.S21S		NM_175068	NP_778238	Q86Y46	K2C73_HUMAN	keratin 73	21	Head.|Gly-rich.					keratin filament	structural molecule activity			large_intestine(2)|ovary(2)|skin(2)	6				BRCA - Breast invasive adenocarcinoma(357;0.189)		AGAGCACAGCGGAGCAGCCGC	0.642			NA											26	86					0	0	0.024334	0	0
FOXA1	3169	broad.mit.edu	37	14	38061461	38061461	+	Missense_Mutation	SNP	G	G	C			TCGA-44-2665-01A-01D-1040-01	TCGA-44-2665-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	520db804-4c03-4a0c-9966-fc0c9f98cfec	4b84f6af-2361-4e9b-9c8c-f1cbeb8513f2	g.chr14:38061461G>C	uc001wuf.2	-	2	840	c.528C>G	c.(526-528)ATC>ATG	p.I176M	FOXA1_uc010tpz.1_Missense_Mutation_p.I143M	NM_004496	NP_004487	P55317	FOXA1_HUMAN	forkhead box A1	176	Fork-head.				chromatin remodeling|embryo development|epithelial cell maturation involved in prostate gland development|epithelial tube branching involved in lung morphogenesis|epithelial-mesenchymal signaling involved in prostate gland development|glucose homeostasis|lung epithelial cell differentiation|negative regulation of survival gene product expression|neuron fate specification|pattern specification process|positive regulation of estrogen receptor signaling pathway|positive regulation of mitotic cell cycle|positive regulation of neuron differentiation|positive regulation of sequence-specific DNA binding transcription factor activity|prostate gland epithelium morphogenesis|prostate gland stromal morphogenesis|response to estradiol stimulus|secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development	transcription factor complex	DNA bending activity|double-stranded DNA binding|protein domain specific binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|transcription regulatory region DNA binding				0	Breast(36;0.0954)|Esophageal squamous(585;0.164)|Hepatocellular(127;0.213)		Lung(238;5.41e-07)|LUAD - Lung adenocarcinoma(48;2.48e-05)|Epithelial(34;0.0454)|LUSC - Lung squamous cell carcinoma(13;0.0917)|all cancers(34;0.0925)|BRCA - Breast invasive adenocarcinoma(188;0.239)	GBM - Glioblastoma multiforme(112;0.0222)		TGATGAGCGAGATGTACGAGT	0.517			NA											15	73					0	0	0.024245	0	0
PAPOLA	10914	broad.mit.edu	37	14	97022682	97022682	+	Missense_Mutation	SNP	A	A	G			TCGA-44-2665-01A-01D-1040-01	TCGA-44-2665-10A-01D-1040-01	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	520db804-4c03-4a0c-9966-fc0c9f98cfec	4b84f6af-2361-4e9b-9c8c-f1cbeb8513f2	g.chr14:97022682A>G	uc001yfq.2	+	19	2146	c.1936A>G	c.(1936-1938)ATA>GTA	p.I646V	PAPOLA_uc001yfr.2_Missense_Mutation_p.I645V|PAPOLA_uc010twv.1_Missense_Mutation_p.I646V|PAPOLA_uc010avp.2_Missense_Mutation_p.I396V	NM_032632	NP_116021	P51003	PAPOA_HUMAN	poly(A) polymerase alpha	646					mRNA polyadenylation|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	cytoplasm|nucleoplasm	ATP binding|magnesium ion binding|manganese ion binding|polynucleotide adenylyltransferase activity|RNA binding				0		all_cancers(154;0.0555)|all_epithelial(191;0.149)|Melanoma(154;0.155)		COAD - Colon adenocarcinoma(157;0.213)		ACCTACTCCTATAGTAGGAGT	0.398	NSCLC(19;254 734 11908 35501 39234)		NA											6	34					0	0	0.021553	0	0
PDIA3	2923	broad.mit.edu	37	15	44038800	44038800	+	Silent	SNP	C	C	T			TCGA-44-2665-01A-01D-1040-01	TCGA-44-2665-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	520db804-4c03-4a0c-9966-fc0c9f98cfec	4b84f6af-2361-4e9b-9c8c-f1cbeb8513f2	g.chr15:44038800C>T	uc001zsu.2	+	1	211	c.63C>T	c.(61-63)CTC>CTT	p.L21L	PDIA3_uc010bdp.2_5'UTR|PDIA3_uc010ued.1_Intron|CATSPER2P1_uc001zss.2_5'Flank|CATSPER2P1_uc001zst.2_RNA	NM_005313	NP_005304	P30101	PDIA3_HUMAN	protein disulfide-isomerase A3 precursor	21					cell redox homeostasis|glycerol ether metabolic process|post-translational protein modification|protein folding|protein import into nucleus|protein N-linked glycosylation via asparagine|protein retention in ER lumen|signal transduction	endoplasmic reticulum lumen|melanosome	cysteine-type endopeptidase activity|electron carrier activity|phospholipase C activity|protein binding|protein disulfide isomerase activity|protein disulfide oxidoreductase activity			ovary(1)|skin(1)	2		all_cancers(109;2.61e-15)|all_epithelial(112;1.12e-12)|Lung NSC(122;2.17e-08)|all_lung(180;2.45e-07)|Melanoma(134;0.027)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;9.48e-07)		CGGCCCGCCTCGCCGCTGCCT	0.706			NA											12	26					0	0	0.010729	0	0
THSD4	79875	broad.mit.edu	37	15	72020908	72020908	+	Missense_Mutation	SNP	C	C	T			TCGA-44-2665-01A-01D-1040-01	TCGA-44-2665-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	520db804-4c03-4a0c-9966-fc0c9f98cfec	4b84f6af-2361-4e9b-9c8c-f1cbeb8513f2	g.chr15:72020908C>T	uc002atb.1	+	8	1457	c.1378C>T	c.(1378-1380)CGC>TGC	p.R460C	THSD4_uc002atd.1_Missense_Mutation_p.R134C|THSD4_uc010ukg.1_Missense_Mutation_p.R100C|THSD4_uc002ate.2_Missense_Mutation_p.R100C	NM_024817	NP_079093	Q6ZMP0	THSD4_HUMAN	thrombospondin, type I, domain containing 4	460						proteinaceous extracellular matrix	metalloendopeptidase activity			ovary(2)	2						TCGTTCTGGACGCTCCATCAT	0.507			NA											9	50					0	0	0.069234	0	0
PDILT	204474	broad.mit.edu	37	16	20370667	20370667	+	Missense_Mutation	SNP	T	T	C			TCGA-44-2665-01A-01D-1040-01	TCGA-44-2665-10A-01D-1040-01	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	520db804-4c03-4a0c-9966-fc0c9f98cfec	4b84f6af-2361-4e9b-9c8c-f1cbeb8513f2	g.chr16:20370667T>C	uc002dhc.1	-	12	1952	c.1729A>G	c.(1729-1731)AAA>GAA	p.K577E		NM_174924	NP_777584	Q8N807	PDILT_HUMAN	protein disulfide isomerase-like, testis	577					cell differentiation|cell redox homeostasis|multicellular organismal development|spermatogenesis	endoplasmic reticulum	isomerase activity			large_intestine(1)	1						ACTTTTGGTTTCTTCTTTTGC	0.448			NA											26	166					0	0	0.01892	0	0
TMCO7	79613	broad.mit.edu	37	16	68941376	68941376	+	Silent	SNP	G	G	A			TCGA-44-2665-01A-01D-1040-01	TCGA-44-2665-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	520db804-4c03-4a0c-9966-fc0c9f98cfec	4b84f6af-2361-4e9b-9c8c-f1cbeb8513f2	g.chr16:68941376G>A	uc002ewi.3	+	10	1710	c.1698G>A	c.(1696-1698)CAG>CAA	p.Q566Q		NM_024562	NP_078838	Q9C0B7	TMCO7_HUMAN	transmembrane and coiled-coil domains 7	566						integral to membrane	binding				0		Ovarian(137;0.0568)		OV - Ovarian serous cystadenocarcinoma(108;0.0446)|Epithelial(162;0.198)		CCCTGTACCAGAAGGTATCCT	0.473			NA											8	77					0	0	0.058154	0	0
CLEC3A	10143	broad.mit.edu	37	16	78064470	78064470	+	Missense_Mutation	SNP	A	A	G			TCGA-44-2665-01A-01D-1040-01	TCGA-44-2665-10A-01D-1040-01	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	520db804-4c03-4a0c-9966-fc0c9f98cfec	4b84f6af-2361-4e9b-9c8c-f1cbeb8513f2	g.chr16:78064470A>G	uc002ffh.3	+	3	407	c.326A>G	c.(325-327)GAC>GGC	p.D109G		NM_005752	NP_005743	O75596	CLC3A_HUMAN	C-type lectin domain family 3 member A	109	C-type lectin.				skeletal system development	extracellular region	sugar binding				0						AGGAACTCCGACGAAATCAAC	0.473			NA											8	61					0	0	0.038147	0	0
ZNF407	55628	broad.mit.edu	37	18	72344697	72344697	+	Silent	SNP	A	A	G			TCGA-44-2665-01A-01D-1040-01	TCGA-44-2665-10A-01D-1040-01	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	520db804-4c03-4a0c-9966-fc0c9f98cfec	4b84f6af-2361-4e9b-9c8c-f1cbeb8513f2	g.chr18:72344697A>G	uc002llw.2	+	1	1779	c.1722A>G	c.(1720-1722)GAA>GAG	p.E574E	ZNF407_uc010xfc.1_Silent_p.E574E|ZNF407_uc010dqu.1_Silent_p.E574E|ZNF407_uc002llu.2_Silent_p.E573E	NM_017757	NP_060227	Q9C0G0	ZN407_HUMAN	zinc finger protein 407 isoform 1	574	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2		Esophageal squamous(42;0.131)|Prostate(75;0.173)		BRCA - Breast invasive adenocarcinoma(31;0.184)		ACTTAGATGAACATTTGCACA	0.398			NA											8	114					0	0	0.038147	0	0
LONP1	9361	broad.mit.edu	37	19	5694505	5694505	+	Missense_Mutation	SNP	G	G	A			TCGA-44-2665-01A-01D-1040-01	TCGA-44-2665-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	520db804-4c03-4a0c-9966-fc0c9f98cfec	4b84f6af-2361-4e9b-9c8c-f1cbeb8513f2	g.chr19:5694505G>A	uc002mcx.2	-	15	2246	c.2213C>T	c.(2212-2214)ACG>ATG	p.T738M	LONP1_uc002mcy.2_Missense_Mutation_p.T674M|LONP1_uc010duh.2_Missense_Mutation_p.T479M|LONP1_uc010dui.2_Missense_Mutation_p.T722M|LONP1_uc002mcz.2_Missense_Mutation_p.T542M	NM_004793	NP_004784	P36776	LONM_HUMAN	mitochondrial lon peptidase 1 precursor	738					cellular chaperone-mediated protein complex assembly|cellular response to oxidative stress|misfolded or incompletely synthesized protein catabolic process|mitochondrial DNA metabolic process|oxidation-dependent protein catabolic process|protein homooligomerization|response to hypoxia	mitochondrial nucleoid	ADP binding|ATP binding|ATP-dependent peptidase activity|DNA polymerase binding|G-quadruplex DNA binding|mitochondrial heavy strand promoter anti-sense binding|mitochondrial light strand promoter anti-sense binding|sequence-specific DNA binding|serine-type endopeptidase activity|single-stranded DNA binding|single-stranded RNA binding				0						GTTCTCGGGCGTCACCTCCAC	0.647			NA											13	78					0	0	0.016723	0	0
SOS1	6654	broad.mit.edu	37	2	39278344	39278344	+	Missense_Mutation	SNP	T	T	C			TCGA-44-2665-01A-01D-1040-01	TCGA-44-2665-10A-01D-1040-01	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	520db804-4c03-4a0c-9966-fc0c9f98cfec	4b84f6af-2361-4e9b-9c8c-f1cbeb8513f2	g.chr2:39278344T>C	uc002rrk.3	-	6	846	c.805A>G	c.(805-807)ATG>GTG	p.M269V	SOS1_uc010ynr.1_RNA|SOS1_uc002rrl.2_Missense_Mutation_p.M1V	NM_005633	NP_005624	Q07889	SOS1_HUMAN	son of sevenless homolog 1	269	DH.		M -> R (in NS4).|M -> T (in NS4).		apoptosis|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|induction of apoptosis by extracellular signals|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	cytosol	DNA binding|protein binding|Rho GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			ovary(4)|breast(3)|lung(2)|central_nervous_system(1)	10		all_hematologic(82;0.21)				TCATCTGTCATTTCTACTGTA	0.378			NA							Noonan_syndrome				4	22					0	0	0.009096	0	0
CNTNAP5	129684	broad.mit.edu	37	2	125671706	125671706	+	Silent	SNP	C	C	T			TCGA-44-2665-01A-01D-1040-01	TCGA-44-2665-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	520db804-4c03-4a0c-9966-fc0c9f98cfec	4b84f6af-2361-4e9b-9c8c-f1cbeb8513f2	g.chr2:125671706C>T	uc002tno.2	+	24	4126	c.3762C>T	c.(3760-3762)ATC>ATT	p.I1254I	CNTNAP5_uc010flu.2_Silent_p.I1255I	NM_130773	NP_570129	Q8WYK1	CNTP5_HUMAN	contactin associated protein-like 5 precursor	1254	Helical; (Potential).				cell adhesion|signal transduction	integral to membrane	receptor binding			ovary(10)	10				BRCA - Breast invasive adenocarcinoma(221;0.248)		TCTTCTGTATCATCGGCATCA	0.473			NA											5	41					0	0	0.02938	0	0
GPR17	2840	broad.mit.edu	37	2	128409116	128409116	+	Silent	SNP	C	C	T	rs144990681		TCGA-44-2665-01A-01D-1040-01	TCGA-44-2665-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	520db804-4c03-4a0c-9966-fc0c9f98cfec	4b84f6af-2361-4e9b-9c8c-f1cbeb8513f2	g.chr2:128409116C>T	uc010yzn.1	+	4	1502	c.891C>T	c.(889-891)TGC>TGT	p.C297C	LIMS2_uc002tox.2_Intron|LIMS2_uc010fmb.2_Intron|LIMS2_uc002toy.2_Intron|LIMS2_uc010yzm.1_Intron|LIMS2_uc002tpa.2_Intron|LIMS2_uc002toz.2_Intron|LIMS2_uc002tpb.2_Intron|GPR17_uc002tpc.2_Silent_p.C297C|GPR17_uc010yzo.1_Silent_p.C269C|GPR17_uc002tpd.2_Silent_p.C269C	NM_001161415	NP_001154887	Q13304	GPR17_HUMAN	G protein-coupled receptor 17 isoform a	297	Extracellular (Potential).					integral to plasma membrane	chemokine receptor activity|purinergic nucleotide receptor activity, G-protein coupled				0	Colorectal(110;0.1)	Ovarian(717;0.15)		BRCA - Breast invasive adenocarcinoma(221;0.0677)		GGGCCTCCTGCGCCACCCAGC	0.622			NA											9	59					0	0	0.047766	0	0
CASP8	841	broad.mit.edu	37	2	202131375	202131375	+	Nonsense_Mutation	SNP	G	G	T			TCGA-44-2665-01A-01D-1040-01	TCGA-44-2665-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	520db804-4c03-4a0c-9966-fc0c9f98cfec	4b84f6af-2361-4e9b-9c8c-f1cbeb8513f2	g.chr2:202131375G>T	uc002uxr.1	+	3	375	c.166G>T	c.(166-168)GAA>TAA	p.E56*	CASP8_uc010ftc.1_Nonsense_Mutation_p.E56*|CASP8_uc002uxo.1_Nonsense_Mutation_p.E56*|CASP8_uc002uxp.1_Nonsense_Mutation_p.E56*|CASP8_uc002uxq.1_Nonsense_Mutation_p.E56*|CASP8_uc002uxs.1_Nonsense_Mutation_p.E56*|CASP8_uc002uxt.1_Nonsense_Mutation_p.E115*|CASP8_uc002uxu.1_RNA|CASP8_uc010ftd.1_Intron|CASP8_uc002uxv.1_Nonsense_Mutation_p.E56*|CASP8_uc002uxw.1_Nonsense_Mutation_p.E56*|CASP8_uc002uxy.1_Nonsense_Mutation_p.E56*|CASP8_uc002uxx.1_Nonsense_Mutation_p.E56*|CASP8_uc010ftf.2_Nonsense_Mutation_p.E56*	NM_033355	NP_203519	Q14790	CASP8_HUMAN	caspase 8 isoform B precursor	56	DED 1.				activation of caspase activity|activation of pro-apoptotic gene products|cellular component disassembly involved in apoptosis|cellular response to mechanical stimulus|induction of apoptosis by extracellular signals|induction of apoptosis by intracellular signals|positive regulation of I-kappaB kinase/NF-kappaB cascade|proteolysis involved in cellular protein catabolic process|response to tumor necrosis factor	centrosome|cytosol|mitochondrial outer membrane	cysteine-type endopeptidase activity|protein binding|protein binding			upper_aerodigestive_tract(2)|ovary(1)|breast(1)|skin(1)	5						AATGTTGGAGGAAAGCAATCT	0.453	Melanoma(82;831 1348 20716 36952 40159)		NA								HNSCC(4;0.00038)			5	26					0.000602214	0.000627307	0.014758	1	0
CASP8	841	broad.mit.edu	37	2	202137390	202137390	+	Missense_Mutation	SNP	G	G	C			TCGA-44-2665-01A-01D-1040-01	TCGA-44-2665-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	520db804-4c03-4a0c-9966-fc0c9f98cfec	4b84f6af-2361-4e9b-9c8c-f1cbeb8513f2	g.chr2:202137390G>C	uc002uxr.1	+	5	650	c.441G>C	c.(439-441)GAG>GAC	p.E147D	CASP8_uc010ftc.1_Missense_Mutation_p.E147D|CASP8_uc002uxo.1_Missense_Mutation_p.E147D|CASP8_uc002uxp.1_Missense_Mutation_p.E179D|CASP8_uc002uxq.1_Missense_Mutation_p.E147D|CASP8_uc002uxs.1_Missense_Mutation_p.E147D|CASP8_uc002uxt.1_Missense_Mutation_p.E206D|CASP8_uc002uxu.1_RNA|CASP8_uc010ftd.1_Missense_Mutation_p.E44D|CASP8_uc002uxv.1_Missense_Mutation_p.E147D|CASP8_uc002uxw.1_Missense_Mutation_p.E147D|CASP8_uc002uxy.1_Missense_Mutation_p.E147D|CASP8_uc002uxx.1_Missense_Mutation_p.E147D|CASP8_uc010ftf.2_Missense_Mutation_p.E147D|CASP8_uc010fte.1_Missense_Mutation_p.E44D	NM_033355	NP_203519	Q14790	CASP8_HUMAN	caspase 8 isoform B precursor	147	DED 2.				activation of caspase activity|activation of pro-apoptotic gene products|cellular component disassembly involved in apoptosis|cellular response to mechanical stimulus|induction of apoptosis by extracellular signals|induction of apoptosis by intracellular signals|positive regulation of I-kappaB kinase/NF-kappaB cascade|proteolysis involved in cellular protein catabolic process|response to tumor necrosis factor	centrosome|cytosol|mitochondrial outer membrane	cysteine-type endopeptidase activity|protein binding|protein binding			upper_aerodigestive_tract(2)|ovary(1)|breast(1)|skin(1)	5						TAGAGATGGAGAAGAGGGTCA	0.398	Melanoma(82;831 1348 20716 36952 40159)		NA								HNSCC(4;0.00038)			23	73					0	0	0.062417	0	0
ANO7	50636	broad.mit.edu	37	2	242148934	242148934	+	Missense_Mutation	SNP	G	G	C			TCGA-44-2665-01A-01D-1040-01	TCGA-44-2665-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	520db804-4c03-4a0c-9966-fc0c9f98cfec	4b84f6af-2361-4e9b-9c8c-f1cbeb8513f2	g.chr2:242148934G>C	uc002wax.2	+	13	1508	c.1405G>C	c.(1405-1407)GCC>CCC	p.A469P		NM_001001891	NP_001001891	Q6IWH7	ANO7_HUMAN	transmembrane protein 16G isoform NGEP long	469	Cytoplasmic (Potential).					cell junction|chloride channel complex|cytosol	chloride channel activity			pancreas(2)|central_nervous_system(1)	3						GCCCCAGTTTGCCGCCTCAGC	0.711			NA											4	23					0	0	0.009096	0	0
FRG1B	284802	broad.mit.edu	37	20	29628263	29628263	+	Missense_Mutation	SNP	A	A	G			TCGA-44-2665-01A-01D-1040-01	TCGA-44-2665-10A-01D-1040-01	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	520db804-4c03-4a0c-9966-fc0c9f98cfec	4b84f6af-2361-4e9b-9c8c-f1cbeb8513f2	g.chr20:29628263A>G	uc010ztl.1	+	3	207	c.175A>G	c.(175-177)ATT>GTT	p.I59V	FRG1B_uc002wvm.1_RNA|FRG1B_uc010ztj.1_RNA|FRG1B_uc010gdr.1_RNA|FRG1B_uc010ztk.1_Missense_Mutation_p.I11V					Homo sapiens cDNA FLJ32537 fis, clone SMINT2000400, highly similar to Homo sapiens FRG1 mRNA.												0						TAGCTGCTTTATTAGATGCAA	0.363			NA											3	11					0	0	0.004672	0	0
PRSS45	377047	broad.mit.edu	37	3	46784015	46784015	+	Missense_Mutation	SNP	A	A	C			TCGA-44-2665-01A-01D-1040-01	TCGA-44-2665-10A-01D-1040-01	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	520db804-4c03-4a0c-9966-fc0c9f98cfec	4b84f6af-2361-4e9b-9c8c-f1cbeb8513f2	g.chr3:46784015A>C	uc010hjl.2	-	4	512	c.512T>G	c.(511-513)GTG>GGG	p.V171G	PRSS45_uc011bam.1_RNA	NM_199183	NP_954652	Q7RTY3	PRS45_HUMAN	testis serine protease 5	203	Peptidase S1.				proteolysis		serine-type endopeptidase activity				0						CCAGGACAACACCCCAGCCAG	0.527			NA											6	59					0	0	0.024245	0	0
NDUFAF3	25915	broad.mit.edu	37	3	49060156	49060156	+	Missense_Mutation	SNP	A	A	G			TCGA-44-2665-01A-01D-1040-01	TCGA-44-2665-10A-01D-1040-01	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	520db804-4c03-4a0c-9966-fc0c9f98cfec	4b84f6af-2361-4e9b-9c8c-f1cbeb8513f2	g.chr3:49060156A>G	uc003cvq.2	+	3	796	c.292A>G	c.(292-294)ACC>GCC	p.T98A	DALRD3_uc003cvm.1_5'Flank|DALRD3_uc010hko.1_5'Flank|uc011bcb.1_5'Flank|MIR425_hsa-mir-425|MI0001448_5'Flank|NDUFAF3_uc003cvn.2_Missense_Mutation_p.T41A|uc003cvo.1_5'Flank|MIR191_hsa-mir-191|MI0000465_5'Flank|NDUFAF3_uc003cvp.2_Missense_Mutation_p.T41A|NDUFAF3_uc003cvr.2_Missense_Mutation_p.T41A|NDUFAF3_uc003cvs.2_Missense_Mutation_p.T41A	NM_199069	NP_951032	Q9BU61	NDUF3_HUMAN	NADH dehydrogenase (ubiquinone) 1 alpha	98					mitochondrial respiratory chain complex I assembly	mitochondrial inner membrane|nucleus	protein binding				0						CCAGGACATCACCGAAGACAG	0.592			NA											31	198					0	0	0.050027	0	0
MST1R	4486	broad.mit.edu	37	3	49928032	49928032	+	Silent	SNP	G	G	A			TCGA-44-2665-01A-01D-1040-01	TCGA-44-2665-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	520db804-4c03-4a0c-9966-fc0c9f98cfec	4b84f6af-2361-4e9b-9c8c-f1cbeb8513f2	g.chr3:49928032G>A	uc003cxy.3	-	18	3960	c.3696C>T	c.(3694-3696)GAC>GAT	p.D1232D	MST1R_uc011bdc.1_Silent_p.D111D	NM_002447	NP_002438	Q04912	RON_HUMAN	macrophage stimulating 1 receptor precursor	1232	Cytoplasmic (Potential).|Protein kinase.				cellular component movement|defense response|multicellular organismal development|positive regulation of cell proliferation|single fertilization|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|macrophage colony-stimulating factor receptor activity|protein binding			ovary(5)|lung(1)	6				BRCA - Breast invasive adenocarcinoma(193;4.65e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.00553)|Kidney(197;0.00625)		TGTCCAGGATGTCGCGGGCCA	0.557			NA											6	25					0	0	0.021553	0	0
CD200	4345	broad.mit.edu	37	3	112068653	112068653	+	Silent	SNP	G	G	C			TCGA-44-2665-01A-01D-1040-01	TCGA-44-2665-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	520db804-4c03-4a0c-9966-fc0c9f98cfec	4b84f6af-2361-4e9b-9c8c-f1cbeb8513f2	g.chr3:112068653G>C	uc003dyw.2	+	6	1008	c.864G>C	c.(862-864)CGG>CGC	p.R288R	CD200_uc010hqd.1_Silent_p.R147R|CD200_uc003dyx.2_Silent_p.R263R|CD200_uc003dyy.2_Silent_p.R147R|CD200_uc003dyz.2_Silent_p.R189R	NM_001004196	NP_001004196	P41217	OX2G_HUMAN	CD200 antigen isoform b	263	Cytoplasmic (Potential).				regulation of immune response	integral to plasma membrane					0		Acute lymphoblastic leukemia(4;1.7e-08)|all_hematologic(4;8.82e-05)				AACGTCACCGGAATCAGGACC	0.358			NA											2	4					0	0	0.004672	0	0
PLXNA1	5361	broad.mit.edu	37	3	126747837	126747837	+	Silent	SNP	G	G	A			TCGA-44-2665-01A-01D-1040-01	TCGA-44-2665-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	520db804-4c03-4a0c-9966-fc0c9f98cfec	4b84f6af-2361-4e9b-9c8c-f1cbeb8513f2	g.chr3:126747837G>A	uc003ejg.2	+	25	4606	c.4602G>A	c.(4600-4602)GAG>GAA	p.E1534E	PLXNA1_uc003ejh.2_Silent_p.E202E	NM_032242	NP_115618	Q9UIW2	PLXA1_HUMAN	plexin A1	1557	Cytoplasmic (Potential).				axon guidance	integral to membrane|intracellular|plasma membrane	semaphorin receptor activity			ovary(1)|pancreas(1)|skin(1)	3				GBM - Glioblastoma multiforme(114;0.155)		CTCCCCCAGAGTGGCGCCAGG	0.647			NA											6	27					0	0	0.021553	0	0
Unknown	0	broad.mit.edu	37	3	129137132	129137132	+	Missense_Mutation	SNP	T	T	G			TCGA-44-2665-01A-01D-1040-01	TCGA-44-2665-10A-01D-1040-01	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	520db804-4c03-4a0c-9966-fc0c9f98cfec	4b84f6af-2361-4e9b-9c8c-f1cbeb8513f2	g.chr3:129137132T>G	uc003emg.2	-	3	809	c.646A>C	c.(646-648)ATC>CTC	p.I216L		NM_207307	NP_997190			hypothetical protein LOC90288												NA						TCCCTGGTGATTCTCTGGTTC	0.547			NA											7	27					0	0	0.038147	0	0
COL25A1	84570	broad.mit.edu	37	4	109817864	109817864	+	Missense_Mutation	SNP	C	C	T			TCGA-44-2665-01A-01D-1040-01	TCGA-44-2665-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	520db804-4c03-4a0c-9966-fc0c9f98cfec	4b84f6af-2361-4e9b-9c8c-f1cbeb8513f2	g.chr4:109817864C>T	uc003hze.1	-	15	1396	c.865G>A	c.(865-867)GAC>AAC	p.D289N	COL25A1_uc003hzg.2_Missense_Mutation_p.D289N|COL25A1_uc003hzd.2_RNA|COL25A1_uc003hzf.2_Missense_Mutation_p.D70N	NM_198721	NP_942014	Q9BXS0	COPA1_HUMAN	collagen, type XXV, alpha 1 isoform 1	289	Extracellular (Potential).|Collagen-like 3.					collagen|extracellular space	beta-amyloid binding|heparin binding			ovary(2)	2		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.000173)		TCTCCAGCGTCTCCCTGAGGA	0.393			NA											8	19					0	0	0.047766	0	0
NAA15	80155	broad.mit.edu	37	4	140265339	140265339	+	Splice_Site	SNP	G	G	A			TCGA-44-2665-01A-01D-1040-01	TCGA-44-2665-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	520db804-4c03-4a0c-9966-fc0c9f98cfec	4b84f6af-2361-4e9b-9c8c-f1cbeb8513f2	g.chr4:140265339G>A	uc003ihu.1	+	6	794	c.538_splice	c.e6-1	p.T180_splice		NM_057175	NP_476516	Q9BXJ9	NAA15_HUMAN	NMDA receptor regulated 1						angiogenesis|cell differentiation|N-terminal protein amino acid acetylation|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|transcription factor complex	protein binding			ovary(1)|skin(1)	2						TCCATATACAGACATCCCCTG	0.333			NA											4	22					0	0	0.009096	0	0
TRIM60	166655	broad.mit.edu	37	4	165962566	165962566	+	Missense_Mutation	SNP	G	G	A			TCGA-44-2665-01A-01D-1040-01	TCGA-44-2665-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	520db804-4c03-4a0c-9966-fc0c9f98cfec	4b84f6af-2361-4e9b-9c8c-f1cbeb8513f2	g.chr4:165962566G>A	uc003iqy.1	+	3	1512	c.1342G>A	c.(1342-1344)GTT>ATT	p.V448I	TRIM60_uc010iqx.1_Missense_Mutation_p.V448I	NM_152620	NP_689833	Q495X7	TRI60_HUMAN	ring finger protein 129	448	B30.2/SPRY.					intracellular	zinc ion binding			skin(1)	1	all_hematologic(180;0.221)	Prostate(90;0.0959)|Melanoma(52;0.18)		GBM - Glioblastoma multiforme(119;0.0844)		CACAGAAGCCGTTTGGCCTTA	0.348			NA											5	24					0	0	0.021553	0	0
FAM149A	25854	broad.mit.edu	37	4	187084634	187084634	+	Missense_Mutation	SNP	C	C	T			TCGA-44-2665-01A-01D-1040-01	TCGA-44-2665-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	520db804-4c03-4a0c-9966-fc0c9f98cfec	4b84f6af-2361-4e9b-9c8c-f1cbeb8513f2	g.chr4:187084634C>T	uc003iyt.3	+	10	1469	c.890C>T	c.(889-891)CCG>CTG	p.P297L	FAM149A_uc011cla.1_Missense_Mutation_p.P297L|FAM149A_uc003iyu.3_Missense_Mutation_p.P297L|FAM149A_uc010isl.2_Missense_Mutation_p.P297L|FAM149A_uc011clb.1_Missense_Mutation_p.P297L	NM_015398	NP_056213	A5PLN7	F149A_HUMAN	hypothetical protein LOC25854	588										breast(1)	1		all_cancers(14;4.27e-52)|all_epithelial(14;7.69e-39)|all_lung(41;1.34e-13)|Lung NSC(41;3.58e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.0066)|Hepatocellular(41;0.00886)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|all_neural(102;0.243)		OV - Ovarian serous cystadenocarcinoma(60;1.19e-10)|BRCA - Breast invasive adenocarcinoma(30;1.22e-05)|GBM - Glioblastoma multiforme(59;0.000122)|STAD - Stomach adenocarcinoma(60;0.000288)|LUSC - Lung squamous cell carcinoma(40;0.00241)|READ - Rectum adenocarcinoma(43;0.166)		TCCTCCGCACCGCACAGACTG	0.493			NA											10	62					0	0	0.010729	0	0
GPR98	84059	broad.mit.edu	37	5	89923108	89923108	+	Silent	SNP	C	C	A			TCGA-44-2665-01A-01D-1040-01	TCGA-44-2665-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	520db804-4c03-4a0c-9966-fc0c9f98cfec	4b84f6af-2361-4e9b-9c8c-f1cbeb8513f2	g.chr5:89923108C>A	uc003kju.2	+	7	849	c.753C>A	c.(751-753)TCC>TCA	p.S251S	GPR98_uc003kjt.2_5'UTR	NM_032119	NP_115495	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98 precursor	251	Extracellular (Potential).				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(11)|central_nervous_system(3)|pancreas(2)	16		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		CTAGGAATTCCATTGAGATCA	0.343			NA											3	14					6.4e-05	6.85714e-05	0.004672	1	0
SPRY4	81848	broad.mit.edu	37	5	141693820	141693820	+	Missense_Mutation	SNP	G	G	C			TCGA-44-2665-01A-01D-1040-01	TCGA-44-2665-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	520db804-4c03-4a0c-9966-fc0c9f98cfec	4b84f6af-2361-4e9b-9c8c-f1cbeb8513f2	g.chr5:141693820G>C	uc003lml.2	-	2	1113	c.854C>G	c.(853-855)GCA>GGA	p.A285G	SPRY4_uc010jgi.1_Missense_Mutation_p.A308G	NM_001127496	NP_001120968	Q9C004	SPY4_HUMAN	sprouty homolog 4 isoform 2	285					multicellular organismal development	cytoplasm|ruffle membrane	protein binding			ovary(1)|lung(1)	2		all_hematologic(541;0.118)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCCGCTGGCTGCTTTGCAGAT	0.627			NA							Testicular_Cancer_Familial_Clustering_of				8	60					0	0	0.047766	0	0
CAMK2A	815	broad.mit.edu	37	5	149636177	149636177	+	Silent	SNP	G	G	A			TCGA-44-2665-01A-01D-1040-01	TCGA-44-2665-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	520db804-4c03-4a0c-9966-fc0c9f98cfec	4b84f6af-2361-4e9b-9c8c-f1cbeb8513f2	g.chr5:149636177G>A	uc003lru.2	-	6	585	c.370C>T	c.(370-372)CTG>TTG	p.L124L	CAMK2A_uc003lrt.2_Silent_p.L124L|CAMK2A_uc010jhe.2_Silent_p.L104L|CAMK2A_uc010jhf.1_5'UTR	NM_171825	NP_741960	Q9UQM7	KCC2A_HUMAN	calcium/calmodulin-dependent protein kinase II	124	Protein kinase.				interferon-gamma-mediated signaling pathway|positive regulation of NF-kappaB transcription factor activity|synaptic transmission	cell junction|cytosol|endocytic vesicle membrane|nucleoplasm|presynaptic membrane	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			large_intestine(1)	1		all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			TGGCAGTGCAGCACAGCCTCC	0.642			NA											3	48					0	0	0.004672	0	0
KCNMB1	3779	broad.mit.edu	37	5	169812334	169812334	+	Missense_Mutation	SNP	G	G	T			TCGA-44-2665-01A-01D-1040-01	TCGA-44-2665-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	520db804-4c03-4a0c-9966-fc0c9f98cfec	4b84f6af-2361-4e9b-9c8c-f1cbeb8513f2	g.chr5:169812334G>T	uc003maq.1	-	2	518	c.118C>A	c.(118-120)CCC>ACC	p.P40T	KCNIP1_uc003map.2_Intron|KCNMB1_uc003mar.2_Missense_Mutation_p.P40T	NM_004137	NP_004128	Q16558	KCMB1_HUMAN	potassium large conductance calcium-activated	40	Extracellular (Potential).				platelet activation|synaptic transmission		calcium-activated potassium channel activity|potassium channel regulator activity			ovary(2)	2	Renal(175;0.000159)|Lung NSC(126;0.0165)|all_lung(126;0.026)	Medulloblastoma(196;0.0109)|all_neural(177;0.0146)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.175)		TGGTAGAGGGGCAGCACAGTC	0.597			NA											13	107					0.00010058	0.000106246	0.013537	1	0
F13A1	2162	broad.mit.edu	37	6	6167746	6167746	+	Missense_Mutation	SNP	T	T	C			TCGA-44-2665-01A-01D-1040-01	TCGA-44-2665-10A-01D-1040-01	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	520db804-4c03-4a0c-9966-fc0c9f98cfec	4b84f6af-2361-4e9b-9c8c-f1cbeb8513f2	g.chr6:6167746T>C	uc003mwv.2	-	13	1976	c.1853A>G	c.(1852-1854)GAT>GGT	p.D618G	F13A1_uc011dib.1_Missense_Mutation_p.D555G	NM_000129	NP_000120	P00488	F13A_HUMAN	coagulation factor XIII A1 subunit precursor	618					peptide cross-linking|platelet activation|platelet degranulation	extracellular region|platelet alpha granule lumen	acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|pancreas(1)|skin(1)	6	Ovarian(93;0.0816)	all_hematologic(90;0.152)			L-Glutamine(DB00130)	GGCCAGAACATCCCTGGTCTC	0.537			NA											10	35					0	0	0.058154	0	0
MAP7	9053	broad.mit.edu	37	6	136681011	136681011	+	Missense_Mutation	SNP	G	G	A			TCGA-44-2665-01A-01D-1040-01	TCGA-44-2665-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	520db804-4c03-4a0c-9966-fc0c9f98cfec	4b84f6af-2361-4e9b-9c8c-f1cbeb8513f2	g.chr6:136681011G>A	uc003qgz.2	-	15	2105	c.1859C>T	c.(1858-1860)ACC>ATC	p.T620I	MAP7_uc011edf.1_Missense_Mutation_p.T605I|MAP7_uc011edg.1_Missense_Mutation_p.T650I|MAP7_uc010kgu.2_Missense_Mutation_p.T642I|MAP7_uc011edh.1_Missense_Mutation_p.T605I|MAP7_uc010kgv.2_Missense_Mutation_p.T642I|MAP7_uc010kgs.2_Missense_Mutation_p.T474I|MAP7_uc011edi.1_Missense_Mutation_p.T474I|MAP7_uc010kgq.1_Missense_Mutation_p.T526I|MAP7_uc003qha.1_Missense_Mutation_p.T583I	NM_003980	NP_003971	Q14244	MAP7_HUMAN	microtubule-associated protein 7	620					establishment or maintenance of cell polarity|microtubule cytoskeleton organization|protein localization in plasma membrane|response to osmotic stress	basolateral plasma membrane|microtubule|microtubule associated complex|nucleus|perinuclear region of cytoplasm	receptor binding|structural molecule activity				0	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00199)|OV - Ovarian serous cystadenocarcinoma(155;0.00643)		CTGATCACTGGTTTTCTACGA	0.328			NA											16	63					0	0	0.038395	0	0
GRM1	2911	broad.mit.edu	37	6	146351336	146351336	+	Missense_Mutation	SNP	C	C	T			TCGA-44-2665-01A-01D-1040-01	TCGA-44-2665-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	520db804-4c03-4a0c-9966-fc0c9f98cfec	4b84f6af-2361-4e9b-9c8c-f1cbeb8513f2	g.chr6:146351336C>T	uc010khw.1	+	2	1153	c.683C>T	c.(682-684)TCT>TTT	p.S228F	GRM1_uc010khu.1_Missense_Mutation_p.S228F|GRM1_uc010khv.1_Missense_Mutation_p.S228F|GRM1_uc003qll.2_Missense_Mutation_p.S228F|GRM1_uc011edz.1_Missense_Mutation_p.S228F|GRM1_uc011eea.1_Missense_Mutation_p.S228F	NM_000838	NP_000829	Q13255	GRM1_HUMAN	glutamate receptor, metabotropic 1 isoform alpha	228	Extracellular (Potential).				synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			lung(8)|ovary(4)|central_nervous_system(3)|large_intestine(2)|breast(2)	19		Ovarian(120;0.0387)		OV - Ovarian serous cystadenocarcinoma(155;5.35e-08)|GBM - Glioblastoma multiforme(68;0.00762)	Acamprosate(DB00659)|L-Glutamic Acid(DB00142)	ACCTATGTCTCTGCAGTCCAC	0.448			NA											10	45					0	0	0.069234	0	0
TNFRSF10B	8795	broad.mit.edu	37	8	22926500	22926500	+	Translation_Start_Site	SNP	G	G	C			TCGA-44-2665-01A-01D-1040-01	TCGA-44-2665-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	520db804-4c03-4a0c-9966-fc0c9f98cfec	4b84f6af-2361-4e9b-9c8c-f1cbeb8513f2	g.chr8:22926500G>C	uc003xcu.2	-	1	201	c.-92C>G	c.(-94--90)ATCTC>ATGTC		uc003xcw.1_Intron|TNFRSF10B_uc003xct.2_Translation_Start_Site|TNFRSF10B_uc011kzq.1_Translation_Start_Site|TNFRSF10B_uc003xcv.2_Translation_Start_Site	NM_003842	NP_003833	O14763	TR10B_HUMAN	tumor necrosis factor receptor superfamily,						activation of NF-kappaB-inducing kinase activity|activation of pro-apoptotic gene products|cell surface receptor linked signaling pathway|cellular response to mechanical stimulus|induction of apoptosis via death domain receptors|positive regulation of I-kappaB kinase/NF-kappaB cascade	plasma membrane	caspase activator activity|receptor activity|TRAIL binding				0		Prostate(55;0.0421)|Breast(100;0.067)		Colorectal(74;0.0179)|COAD - Colon adenocarcinoma(73;0.0703)		TGGGCGCAGAGATTGCGGGGT	0.597	GBM(94;1064 1342 1839 21060 42553)		NA											6	26					0	0	0.021553	0	0
WRN	7486	broad.mit.edu	37	8	30945312	30945312	+	Missense_Mutation	SNP	T	T	A			TCGA-44-2665-01A-01D-1040-01	TCGA-44-2665-10A-01D-1040-01	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	520db804-4c03-4a0c-9966-fc0c9f98cfec	4b84f6af-2361-4e9b-9c8c-f1cbeb8513f2	g.chr8:30945312T>A	uc003xio.3	+	12	2240	c.1452T>A	c.(1450-1452)AGT>AGA	p.S484R	WRN_uc011lbe.1_Missense_Mutation_p.S12R|WRN_uc010lvk.2_5'UTR	NM_000553	NP_000544	Q14191	WRN_HUMAN	Werner syndrome protein	484					base-excision repair|cellular response to starvation|DNA recombination|DNA synthesis involved in DNA repair|multicellular organismal aging|nucleolus to nucleoplasm transport|positive regulation of hydrolase activity|regulation of apoptosis|replication fork processing|response to oxidative stress|response to UV-C|telomere maintenance	centrosome|nucleolus|nucleoplasm	3'-5' exonuclease activity|ATP binding|ATP-dependent 3'-5' DNA helicase activity|bubble DNA binding|four-way junction helicase activity|G-quadruplex DNA binding|magnesium ion binding|manganese ion binding|protein complex binding|protein homodimerization activity|Y-form DNA binding			ovary(2)|kidney(2)|large_intestine(1)|lung(1)|skin(1)	7		Breast(100;0.195)		KIRC - Kidney renal clear cell carcinoma(542;0.147)|Kidney(114;0.176)|Colorectal(111;0.192)		ACCTCAATAGTGGCACGGTAG	0.279	Ovarian(18;161 598 2706 14834 27543)		NA	Mis|N|F|S			osteosarcoma|meningioma|others		Genes_defective_in_diseases_associated_with_sensitivity_to_DNA_damaging_agents	Werner_syndrome				4	24					0	0	0.014758	0	0
NRG1	3084	broad.mit.edu	37	8	32621515	32621515	+	Silent	SNP	G	G	A			TCGA-44-2665-01A-01D-1040-01	TCGA-44-2665-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	520db804-4c03-4a0c-9966-fc0c9f98cfec	4b84f6af-2361-4e9b-9c8c-f1cbeb8513f2	g.chr8:32621515G>A	uc003xiv.2	+	12	2035	c.1518G>A	c.(1516-1518)GCG>GCA	p.A506A	NRG1_uc010lvo.2_3'UTR|NRG1_uc003xiu.2_Silent_p.A511A|NRG1_uc003xiw.2_Silent_p.A503A|NRG1_uc003xit.2_3'UTR|NRG1_uc010lvr.2_Silent_p.A248A|NRG1_uc010lvs.2_Silent_p.A248A|NRG1_uc010lvp.2_Silent_p.A460A|NRG1_uc010lvq.2_Silent_p.A443A|NRG1_uc011lbg.1_3'UTR|NRG1_uc011lbh.1_Silent_p.A349A|NRG1_uc003xja.2_Silent_p.A317A	NM_013964	NP_039258	Q02297	NRG1_HUMAN	neuregulin 1 isoform HRG-alpha	506	Cytoplasmic (Potential).				activation of transmembrane receptor protein tyrosine kinase activity|anti-apoptosis|cardiac muscle cell differentiation|cell communication|cell proliferation|cellular protein complex disassembly|embryo development|mammary gland development|negative regulation of cardiac muscle cell apoptosis|negative regulation of secretion|negative regulation of transcription, DNA-dependent|nervous system development|neural crest cell development|Notch signaling pathway|positive regulation of cardiac muscle cell proliferation|positive regulation of cell adhesion|positive regulation of cell growth|positive regulation of striated muscle cell differentiation|regulation of protein heterodimerization activity|regulation of protein homodimerization activity|transmembrane receptor protein tyrosine kinase signaling pathway|ventricular cardiac muscle cell differentiation|wound healing|wound healing	apical plasma membrane|extracellular region|extracellular space|integral to membrane|nucleus|plasma membrane	cytokine activity|ErbB-3 class receptor binding|growth factor activity|growth factor activity|protein binding|protein tyrosine kinase activator activity|receptor tyrosine kinase binding|transcription cofactor activity|transmembrane receptor protein tyrosine kinase activator activity				0		Breast(100;0.203)		KIRC - Kidney renal clear cell carcinoma(67;0.0768)|Kidney(114;0.0943)		ACAACCCCGCGCATGACAGTA	0.542			NA											4	33					0	0	0.009096	0	0
TESK1	7016	broad.mit.edu	37	9	35609179	35609179	+	Missense_Mutation	SNP	T	T	C			TCGA-44-2665-01A-01D-1040-01	TCGA-44-2665-10A-01D-1040-01	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	520db804-4c03-4a0c-9966-fc0c9f98cfec	4b84f6af-2361-4e9b-9c8c-f1cbeb8513f2	g.chr9:35609179T>C	uc003zxa.2	+	10	1657	c.1321T>C	c.(1321-1323)TCC>CCC	p.S441P	TESK1_uc003zwz.1_RNA|TESK1_uc010mks.2_Missense_Mutation_p.S281P	NM_006285	NP_006276	Q15569	TESK1_HUMAN	testis-specific protein kinase 1	441					cell junction assembly|spermatogenesis	cytosol	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			stomach(2)|breast(2)|lung(1)|ovary(1)|skin(1)	7			Lung(28;0.00276)|LUSC - Lung squamous cell carcinoma(32;0.00418)|STAD - Stomach adenocarcinoma(86;0.194)			ACTACCCTCATCCCCCGAGCT	0.672			NA											7	66					0	0	0.037714	0	0
APBA1	320	broad.mit.edu	37	9	72131361	72131361	+	Missense_Mutation	SNP	C	C	T			TCGA-44-2665-01A-01D-1040-01	TCGA-44-2665-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	520db804-4c03-4a0c-9966-fc0c9f98cfec	4b84f6af-2361-4e9b-9c8c-f1cbeb8513f2	g.chr9:72131361C>T	uc004ahh.2	-	2	1042	c.766G>A	c.(766-768)GCG>ACG	p.A256T		NM_001163	NP_001154	Q02410	APBA1_HUMAN	amyloid beta A4 precursor protein-binding,	256	Munc-18-1 binding.				axon cargo transport|cell adhesion|intracellular protein transport|nervous system development|protein complex assembly|synaptic transmission	synaptic vesicle				lung(1)	1						GGGTAGGGCGCGAACTCGGCC	0.687			NA											7	32					0	0	0.038147	0	0
HSPA5	3309	broad.mit.edu	37	9	128000573	128000573	+	Missense_Mutation	SNP	G	G	A			TCGA-44-2665-01A-01D-1040-01	TCGA-44-2665-10A-01D-1040-01	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	520db804-4c03-4a0c-9966-fc0c9f98cfec	4b84f6af-2361-4e9b-9c8c-f1cbeb8513f2	g.chr9:128000573G>A	uc004bpn.2	-	7	1505	c.1249C>T	c.(1249-1251)CTT>TTT	p.L417F		NM_005347	NP_005338	P11021	GRP78_HUMAN	heat shock 70kDa protein 5	417					anti-apoptosis|cellular response to glucose starvation|ER-associated protein catabolic process|platelet activation|platelet degranulation|regulation of protein folding in endoplasmic reticulum	cell surface|endoplasmic reticulum chaperone complex|endoplasmic reticulum lumen|ER-Golgi intermediate compartment|integral to endoplasmic reticulum membrane|melanosome|midbody|nucleus|perinuclear region of cytoplasm	ATP binding|ATPase activity|calcium ion binding|caspase inhibitor activity|chaperone binding|misfolded protein binding|protein binding, bridging|protein domain specific binding|ubiquitin protein ligase binding|unfolded protein binding			ovary(3)|skin(1)	4					Antihemophilic Factor(DB00025)	CATACATCAAGCAGTACCAGG	0.398			NA								Prostate(1;0.17)			11	32					0	0	0.020292	0	0
MXRA5	25878	broad.mit.edu	37	X	3241386	3241386	+	Silent	SNP	C	C	T			TCGA-44-2665-01A-01D-1040-01	TCGA-44-2665-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	520db804-4c03-4a0c-9966-fc0c9f98cfec	4b84f6af-2361-4e9b-9c8c-f1cbeb8513f2	g.chrX:3241386C>T	uc004crg.3	-	5	2497	c.2340G>A	c.(2338-2340)CCG>CCA	p.P780P		NM_015419	NP_056234	Q9NR99	MXRA5_HUMAN	adlican precursor	780						extracellular region				ovary(5)|lung(1)|central_nervous_system(1)|skin(1)	8		all_lung(23;0.00031)|Lung NSC(23;0.000946)				CCCAGCGCTCCGGATTAATCT	0.453			NA											14	57					0	0	0.020292	0	0
MSL3	10943	broad.mit.edu	37	X	11783605	11783605	+	Missense_Mutation	SNP	C	C	T			TCGA-44-2665-01A-01D-1040-01	TCGA-44-2665-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	520db804-4c03-4a0c-9966-fc0c9f98cfec	4b84f6af-2361-4e9b-9c8c-f1cbeb8513f2	g.chrX:11783605C>T	uc004cuw.2	+	9	1033	c.928C>T	c.(928-930)CCC>TCC	p.P310S	MSL3_uc004cuv.1_Missense_Mutation_p.P310S|MSL3_uc004cux.2_Missense_Mutation_p.P251S|MSL3_uc011mig.1_Missense_Mutation_p.P161S|MSL3_uc011mih.1_Missense_Mutation_p.P298S|MSL3_uc004cuy.2_Missense_Mutation_p.P144S	NM_078629	NP_523353	Q8N5Y2	MS3L1_HUMAN	male-specific lethal 3-like 1 isoform a	310					histone H4-K16 acetylation|multicellular organismal development|transcription from RNA polymerase II promoter	MSL complex	DNA binding|methylated histone residue binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1						GGAACTCTCTCCCAGTCCGCC	0.557			NA											4	121					0	0	0.014758	0	0
PLP2	5355	broad.mit.edu	37	X	49029495	49029495	+	Missense_Mutation	SNP	T	T	C			TCGA-44-2665-01A-01D-1040-01	TCGA-44-2665-10A-01D-1040-01	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	520db804-4c03-4a0c-9966-fc0c9f98cfec	4b84f6af-2361-4e9b-9c8c-f1cbeb8513f2	g.chrX:49029495T>C	uc004dmx.2	+	2	191	c.116T>C	c.(115-117)CTG>CCG	p.L39P		NM_002668	NP_002659	Q04941	PLP2_HUMAN	proteolipid protein 2 (colonic	39	Helical; (Potential).|MARVEL.				chemotaxis|cytokine-mediated signaling pathway	endoplasmic reticulum membrane|integral to membrane|membrane fraction|plasma membrane	chemokine binding|ion transmembrane transporter activity				0						CTGGTGATCCTGATCTGCTTC	0.493			NA											6	29					0	0	0.02938	0	0
MSN	4478	broad.mit.edu	37	X	64959737	64959737	+	Silent	SNP	C	C	T			TCGA-44-2665-01A-01D-1040-01	TCGA-44-2665-10A-01D-1040-01	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	520db804-4c03-4a0c-9966-fc0c9f98cfec	4b84f6af-2361-4e9b-9c8c-f1cbeb8513f2	g.chrX:64959737C>T	uc004dwf.2	+	13	1914	c.1716C>T	c.(1714-1716)GAC>GAT	p.D572D		NM_002444	NP_002435	P26038	MOES_HUMAN	moesin	572					leukocyte cell-cell adhesion|leukocyte migration|membrane to membrane docking	apical plasma membrane|cytoskeleton|extrinsic to membrane|microvillus membrane|nucleolus	cell adhesion molecule binding|receptor binding|structural constituent of cytoskeleton		MSN/ALK(6)	haematopoietic_and_lymphoid_tissue(6)|ovary(3)|lung(1)	10						AGCGCATTGACGAATTTGAGT	0.532			NA	T	ALK	ALCL								7	82					0	0	0.047766	0	0
ZFHX3	463	broad.mit.edu	37	16	72991713	72991715	+	In_Frame_Del	DEL	CCA	CCA	-	rs4788682	by1000genomes	TCGA-44-2665-01A-01D-1040-01	TCGA-44-2665-10A-01D-1040-01	CCA	CCA	-	-	CCA	CCA	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	520db804-4c03-4a0c-9966-fc0c9f98cfec	4b84f6af-2361-4e9b-9c8c-f1cbeb8513f2	g.chr16:72991713_72991715delCCA	uc002fck.2	-	2	3003_3005	c.2330_2332delTGG	c.(2329-2334)GTGGCT>GCT	p.V777del	ZFHX3_uc002fcl.2_Intron	NM_006885	NP_008816	Q15911	ZFHX3_HUMAN	zinc finger homeobox 3 isoform A	777	Poly-Ala.				muscle organ development|negative regulation of myoblast differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|positive regulation of myoblast differentiation	transcription factor complex	enzyme binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(2)|skin(2)	4		Ovarian(137;0.13)				gccgccgcagccaccgccgccgc	0.458			NA											7	157	---	---	---	---	NA	NA	NA	NA	NA
VEZF1	7716	broad.mit.edu	37	17	56056604	56056605	+	In_Frame_Ins	INS	-	-	TGC	rs138088904	byFrequency	TCGA-44-2665-01A-01D-1040-01	TCGA-44-2665-10A-01D-1040-01	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	520db804-4c03-4a0c-9966-fc0c9f98cfec	4b84f6af-2361-4e9b-9c8c-f1cbeb8513f2	g.chr17:56056604_56056605insTGC	uc002ivf.1	-	5	1189_1190	c.1046_1047insGCA	c.(1045-1047)CAA>CAGCAA	p.349_349Q>QQ	VEZF1_uc010dcn.1_In_Frame_Ins_p.199_199Q>QQ	NM_007146	NP_009077	Q14119	VEZF1_HUMAN	zinc finger protein 161	349	Poly-Gln.				cellular defense response|regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleus	DNA binding|zinc ion binding			ovary(1)|breast(1)	2						gttgttgttgttgctgctgctg	0.307			NA											10	120	---	---	---	---	NA	NA	NA	NA	NA