Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	ACHILLES_Top_Genes	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
MST1P9	11223	broad.mit.edu	37	1	17085791	17085791	+	Missense_Mutation	SNP	G	G	A	rs2297532	by1000genomes	TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr1:17085791G>A	uc010ock.1	-	8	1030	c.1030C>T	c.(1030-1032)CGT>TGT	p.R344C	CROCC_uc009voy.1_Intron|MST1P9_uc001azp.3_5'UTR	NR_002729				SubName: Full=Hepatocyte growth factor-like protein homolog;												0						TCTGTACAACGCCGGATCTGG	0.692			NA											4	23					0	0	0.02938	0	0
KIAA0090	23065	broad.mit.edu	37	1	19545844	19545844	+	Missense_Mutation	SNP	T	T	A			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr1:19545844T>A	uc001bbo.2	-	23	2978	c.2935A>T	c.(2935-2937)ACT>TCT	p.T979S	KIAA0090_uc001bbn.2_RNA|KIAA0090_uc001bbp.2_Missense_Mutation_p.T978S|KIAA0090_uc001bbq.2_Missense_Mutation_p.T978S|KIAA0090_uc001bbr.2_Missense_Mutation_p.T957S	NM_015047	NP_055862	Q8N766	K0090_HUMAN	hypothetical protein LOC23065 precursor	979	DUF1620.|Helical; (Potential).					integral to membrane	protein binding			ovary(1)	1		Colorectal(325;0.000147)|Renal(390;0.000469)|Breast(348;0.00366)|all_lung(284;0.00519)|Lung NSC(340;0.00544)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0707)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00492)|BRCA - Breast invasive adenocarcinoma(304;3.84e-05)|Kidney(64;0.000191)|KIRC - Kidney renal clear cell carcinoma(64;0.00274)|GBM - Glioblastoma multiforme(114;0.005)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0656)		AGTCTCTTAGTGATCATGGTG	0.498	GBM(4;72 124 25802 30195)		NA											9	41					0	0	0.010729	0	0
C1orf91	56063	broad.mit.edu	37	1	32682936	32682936	+	Silent	SNP	C	C	A			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr1:32682936C>A	uc009vub.1	-	4	255	c.252G>T	c.(250-252)GTG>GTT	p.V84V	C1orf91_uc001buo.3_RNA|C1orf91_uc001bup.3_RNA|C1orf91_uc010oha.1_RNA|C1orf91_uc001buq.3_Silent_p.V84V			Q8WY98	TM234_HUMAN	RecName: Full=UPF0546 membrane protein C1orf91;	84	Helical; (Potential).					integral to membrane					0		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.186)				TACAGATGGGCACAGCCAGGG	0.453			NA											7	66					0.000157383	0.000175297	0.038147	1	0
ORC1L	4998	broad.mit.edu	37	1	52867116	52867116	+	Silent	SNP	G	G	A			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr1:52867116G>A	uc001ctt.2	-	3	360	c.141C>T	c.(139-141)ATC>ATT	p.I47I	ORC1L_uc010oni.1_Silent_p.I47I|ORC1L_uc001ctu.2_Silent_p.I47I|ORC1L_uc009vzd.2_Intron	NM_004153	NP_004144	Q13415	ORC1_HUMAN	origin recognition complex, subunit 1	47	BAH.				cell cycle checkpoint|DNA-dependent DNA replication initiation|M/G1 transition of mitotic cell cycle|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle	cytosol|nuclear origin of replication recognition complex|nucleolus|nucleoplasm|plasma membrane	ATP binding|DNA binding|nucleoside-triphosphatase activity|protein binding				0						GTCCAATCTGGATGTGAATCT	0.408			NA											16	92					0	0	0.028581	0	0
CD1D	912	broad.mit.edu	37	1	158153922	158153922	+	Silent	SNP	C	C	T			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr1:158153922C>T	uc001frr.2	+	7	1489	c.990C>T	c.(988-990)TCC>TCT	p.S330S	CD1D_uc009wss.2_Silent_p.S237S	NM_001766	NP_001757	P15813	CD1D_HUMAN	CD1D antigen precursor	330	Cytoplasmic (Potential).				antigen processing and presentation, endogenous lipid antigen via MHC class Ib|detection of bacterium|innate immune response|interspecies interaction between organisms|positive regulation of innate immune response|T cell selection	endosome membrane|integral to plasma membrane|lysosomal membrane	beta-2-microglobulin binding|exogenous lipid antigen binding|histone binding			ovary(1)	1	all_hematologic(112;0.0378)					CTCACAGTTCCTATCAGGGCG	0.517			NA											3	110					0	0	0.009096	0	0
PAPPA2	60676	broad.mit.edu	37	1	176564566	176564566	+	Missense_Mutation	SNP	G	G	A			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr1:176564566G>A	uc001gkz.2	+	3	2990	c.1826G>A	c.(1825-1827)GGG>GAG	p.G609E	PAPPA2_uc001gky.1_Missense_Mutation_p.G609E|PAPPA2_uc009www.2_RNA	NM_020318	NP_064714	Q9BXP8	PAPP2_HUMAN	pappalysin 2 isoform 1	609	Metalloprotease.				cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			ovary(7)|central_nervous_system(5)|skin(2)|lung(1)|breast(1)	16						GGCTATGATGGGGGTGACTGC	0.587			NA											6	66					0	0	0.021553	0	0
CTSE	1510	broad.mit.edu	37	1	206325297	206325297	+	Silent	SNP	G	G	A			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr1:206325297G>A	uc001hdu.2	+	5	640	c.522G>A	c.(520-522)CAG>CAA	p.Q174Q	CTSE_uc001hdv.2_Silent_p.Q174Q|CTSE_uc010prs.1_Silent_p.Q99Q	NM_001910	NP_001901	P14091	CATE_HUMAN	cathepsin E isoform a preproprotein	179					antigen processing and presentation of exogenous peptide antigen via MHC class II|digestion|proteolysis	endosome	aspartic-type endopeptidase activity			ovary(1)	1			BRCA - Breast invasive adenocarcinoma(75;0.0754)			AGCCAGGCCAGACCTTTGTGG	0.532			NA											3	57					0	0	0.004672	0	0
OR2T11	127077	broad.mit.edu	37	1	248790184	248790184	+	Missense_Mutation	SNP	C	C	G			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr1:248790184C>G	uc001ier.1	-	1	246	c.246G>C	c.(244-246)ATG>ATC	p.M82I		NM_001001964	NP_001001964	Q8NH01	O2T11_HUMAN	olfactory receptor, family 2, subfamily T,	82	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			lung(1)	1	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			CTTTAGAAACCATGTCTGCCA	0.502			NA											14	37					0	0	0.020292	0	0
ITIH5	80760	broad.mit.edu	37	10	7618423	7618423	+	Silent	SNP	C	C	T			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr10:7618423C>T	uc001ijq.2	-	10	2050	c.1971G>A	c.(1969-1971)ACG>ACA	p.T657T	ITIH5_uc001ijp.2_Silent_p.T443T|ITIH5_uc001ijr.1_Silent_p.T657T	NM_030569	NP_085046	Q86UX2	ITIH5_HUMAN	inter-alpha trypsin inhibitor heavy chain	657					hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			ovary(2)|central_nervous_system(2)	4						TACCTGGCTGCGTGCCAGCTC	0.682			NA											4	18					0	0	0.009096	0	0
MSRB2	22921	broad.mit.edu	37	10	23408331	23408331	+	Missense_Mutation	SNP	G	G	T			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr10:23408331G>T	uc001iro.2	+	4	506	c.395G>T	c.(394-396)CGT>CTT	p.R132L		NM_012228	NP_036360	Q9Y3D2	MSRB2_HUMAN	methionine sulfoxide reductase B2 precursor	132					protein repair	mitochondrion	peptide-methionine-(S)-S-oxide reductase activity|protein-methionine-R-oxide reductase activity|sequence-specific DNA binding transcription factor activity|zinc ion binding				0					L-Methionine(DB00134)	ATCCTGAGACGTCTGGATACC	0.517	Esophageal Squamous(89;1240 1363 4973 30188 42299)		NA											8	73					0.00448238	0.00472374	0.004482	1	0
GPR158	57512	broad.mit.edu	37	10	25886922	25886922	+	Missense_Mutation	SNP	G	G	C			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr10:25886922G>C	uc001isj.2	+	11	2427	c.2367G>C	c.(2365-2367)AGG>AGC	p.R789S	GPR158_uc001isk.2_Missense_Mutation_p.R164S	NM_020752	NP_065803	Q5T848	GP158_HUMAN	G protein-coupled receptor 158 precursor	789	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(4)|large_intestine(2)|pancreas(1)|skin(1)	8						CCCTCATCAGGAAGAACCCCC	0.552			NA											13	67					0	0	0.016723	0	0
BMS1	9790	broad.mit.edu	37	10	43315759	43315759	+	Missense_Mutation	SNP	G	G	A			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr10:43315759G>A	uc001jaj.2	+	16	3014	c.2656G>A	c.(2656-2658)GTC>ATC	p.V886I		NM_014753	NP_055568	Q14692	BMS1_HUMAN	BMS1-like, ribosome assembly protein	886					ribosome assembly	nucleolus	ATP binding|GTP binding|GTPase activity			ovary(2)|upper_aerodigestive_tract(1)	3						TGGGATGTACGTCCGCATTGA	0.448			NA											15	70					0	0	0.020292	0	0
LRRTM3	347731	broad.mit.edu	37	10	68687143	68687143	+	Silent	SNP	C	C	A			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr10:68687143C>A	uc001jmz.1	+	2	1019	c.469C>A	c.(469-471)CGG>AGG	p.R157R	CTNNA3_uc009xpn.1_Intron|CTNNA3_uc001jmw.2_Intron|CTNNA3_uc001jmx.3_Intron|CTNNA3_uc009xpo.1_Intron|LRRTM3_uc001jmy.2_Silent_p.R157R	NM_178011	NP_821079	Q86VH5	LRRT3_HUMAN	leucine rich repeat transmembrane neuronal 3	157	Extracellular (Potential).					integral to membrane				upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3						TCGGGGCTTGCGGAAGCTGCT	0.458			NA											16	115					3.32936e-07	4.07252e-07	0.038395	1	0
FAM178A	55719	broad.mit.edu	37	10	102678196	102678196	+	Missense_Mutation	SNP	C	C	T			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr10:102678196C>T	uc001krt.3	+	4	1513	c.971C>T	c.(970-972)TCA>TTA	p.S324L	FAM178A_uc001krr.1_Missense_Mutation_p.S324L|FAM178A_uc001krs.2_Missense_Mutation_p.S324L|FAM178A_uc001kru.1_Missense_Mutation_p.S260L	NM_018121	NP_060591	Q8IX21	F178A_HUMAN	hypothetical protein LOC55719 isoform 1	324											0						GAACCTACTTCAGGTAGAATC	0.299			NA											20	141					0	0	0.043863	0	0
VENTX	27287	broad.mit.edu	37	10	135053498	135053498	+	Silent	SNP	G	G	A			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr10:135053498G>A	uc010quy.1	+	3	476	c.465G>A	c.(463-465)CTG>CTA	p.L155L		NM_014468	NP_055283	O95231	VENTX_HUMAN	VENT homeobox	155					multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0		all_cancers(35;4.15e-10)|all_epithelial(44;2.07e-08)|Lung NSC(174;0.000845)|all_lung(145;0.00144)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.172)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;7.8e-06)|Epithelial(32;9.31e-06)|all cancers(32;1.19e-05)		ACCCCCAGCTGCACAGCCCCT	0.562			NA											13	77					0	0	0.020292	0	0
OR52R1	119695	broad.mit.edu	37	11	4824855	4824855	+	Missense_Mutation	SNP	C	C	A			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr11:4824855C>A	uc010qym.1	-	1	993	c.993G>T	c.(991-993)TTG>TTT	p.L331F		NM_001005177	NP_001005177	Q8NGF1	O52R1_HUMAN	olfactory receptor, family 52, subfamily R,	252	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1		Medulloblastoma(188;0.0025)|Breast(177;0.0184)|all_neural(188;0.0227)		Epithelial(150;4.77e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00435)|LUSC - Lung squamous cell carcinoma(625;0.19)		TATAAAGAGCCAAGATGACAC	0.473			NA											14	74					3.27435e-08	4.15358e-08	0.020292	1	0
OR52N1	79473	broad.mit.edu	37	11	5809322	5809322	+	Missense_Mutation	SNP	G	G	T			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr11:5809322G>T	uc010qzo.1	-	1	725	c.725C>A	c.(724-726)ACC>AAC	p.T242N	TRIM5_uc001mbq.1_Intron|TRIM22_uc009yet.1_Intron	NM_001001913	NP_001001913	Q8NH53	O52N1_HUMAN	olfactory receptor, family 52, subfamily N,	242	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;3.05e-11)|LUSC - Lung squamous cell carcinoma(625;0.112)|BRCA - Breast invasive adenocarcinoma(625;0.135)|Lung(200;0.195)		GGCAGTGCAGGTGCTGAAGGC	0.473			NA											8	60					0.000157383	0.000175297	0.038147	1	0
ST5	6764	broad.mit.edu	37	11	8751902	8751902	+	Missense_Mutation	SNP	C	C	T			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr11:8751902C>T	uc001mgt.2	-	3	1121	c.935G>A	c.(934-936)CGG>CAG	p.R312Q	ST5_uc009yfr.2_Intron|ST5_uc001mgu.2_Intron|ST5_uc001mgv.2_Missense_Mutation_p.R312Q|ST5_uc010rbq.1_Intron|ST5_uc001mgw.1_Missense_Mutation_p.R312Q	NM_213618	NP_998783	P78524	ST5_HUMAN	suppression of tumorigenicity 5 isoform 1	312					positive regulation of ERK1 and ERK2 cascade		protein binding			upper_aerodigestive_tract(1)	1				Epithelial(150;2.63e-07)|BRCA - Breast invasive adenocarcinoma(625;0.0352)		CCTTTTCCCCCGGTCCACGCT	0.667			NA											17	71					0	0	0.010504	0	0
OR4A16	81327	broad.mit.edu	37	11	55110891	55110891	+	Missense_Mutation	SNP	C	C	A			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr11:55110891C>A	uc010rie.1	+	1	215	c.215C>A	c.(214-216)TCC>TAC	p.S72Y		NM_001005274	NP_001005274	Q8NH70	O4A16_HUMAN	olfactory receptor, family 4, subfamily A,	72	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(2)|pancreas(1)	3						GCCATATATTCCACTGCCATG	0.443			NA											43	155					6.61955e-31	8.97899e-31	0.01441	1	0
OR1S2	219958	broad.mit.edu	37	11	57971611	57971611	+	Missense_Mutation	SNP	G	G	T			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr11:57971611G>T	uc010rkb.1	-	1	43	c.43C>A	c.(43-45)CAT>AAT	p.H15N		NM_001004459	NP_001004459	Q8NGQ3	OR1S2_HUMAN	olfactory receptor, family 1, subfamily S,	15	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		Breast(21;0.0589)				TTTTCTTGATGCATATTTCTG	0.413			NA											17	95					1.02788e-11	1.32849e-11	0.0333	1	0
MS4A4A	51338	broad.mit.edu	37	11	60070111	60070111	+	Missense_Mutation	SNP	C	C	T			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr11:60070111C>T	uc001noz.2	+	5	477	c.467C>T	c.(466-468)GCG>GTG	p.A156V	MS4A4A_uc001npa.2_Missense_Mutation_p.A137V|MS4A4A_uc001npb.2_Missense_Mutation_p.A137V|MS4A4A_uc001npc.2_Intron	NM_148975	NP_683876	Q96JQ5	M4A4A_HUMAN	membrane-spanning 4-domains, subfamily A, member	156	Helical; (Potential).					integral to membrane	receptor activity				0						TTTAGCTTGGCGTTTTATTCA	0.403			NA											8	105					0	0	0.038147	0	0
DNAJC4	3338	broad.mit.edu	37	11	63999376	63999376	+	Silent	SNP	G	G	A			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr11:63999376G>A	uc001nys.2	+	3	582	c.120G>A	c.(118-120)GGG>GGA	p.G40G	uc001nyr.1_5'Flank|DNAJC4_uc001nyt.2_Silent_p.G40G|DNAJC4_uc001nyu.2_Silent_p.G40G|VEGFB_uc001nyw.2_5'Flank|VEGFB_uc001nyx.2_5'Flank	NM_005528	NP_005519	Q9NNZ3	DNJC4_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 4	40	J.				protein folding|response to unfolded protein	integral to membrane|membrane fraction	heat shock protein binding|unfolded protein binding				0						AACTGTTGGGGGTGCATCCTG	0.552			NA											7	55					0	0	0.038147	0	0
CAPN5	726	broad.mit.edu	37	11	76829343	76829343	+	Missense_Mutation	SNP	A	A	G			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr11:76829343A>G	uc001oxx.2	+	8	1297	c.1112A>G	c.(1111-1113)CAG>CGG	p.Q371R	CAPN5_uc009yup.2_Missense_Mutation_p.Q411R|CAPN5_uc009yuq.2_Missense_Mutation_p.Q407R|CAPN5_uc001oxy.2_Missense_Mutation_p.Q411R|CAPN5_uc001oya.2_5'Flank	NM_004055	NP_004046	O15484	CAN5_HUMAN	calpain 5	371	Domain III.				proteolysis|signal transduction	intracellular	calcium-dependent cysteine-type endopeptidase activity				0						GACCCGCGACAGAACCGCGGT	0.632			NA											3	18					0	0	0.004672	0	0
USP28	57646	broad.mit.edu	37	11	113702712	113702712	+	Missense_Mutation	SNP	C	C	T			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr11:113702712C>T	uc001poh.2	-	8	796	c.763G>A	c.(763-765)GAT>AAT	p.D255N	USP28_uc001pog.2_5'Flank|USP28_uc010rwy.1_Missense_Mutation_p.D130N|USP28_uc001poi.2_Splice_Site|USP28_uc001poj.3_Missense_Mutation_p.D255N|USP28_uc010rwz.1_Intron	NM_020886	NP_065937	Q96RU2	UBP28_HUMAN	ubiquitin specific protease 28	255					cell proliferation|DNA damage checkpoint|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA repair|protein deubiquitination|response to ionizing radiation|ubiquitin-dependent protein catabolic process	nucleolus|nucleoplasm	protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			lung(2)|breast(2)|ovary(1)|large_intestine(1)|kidney(1)	7		all_cancers(61;3.74e-18)|all_epithelial(67;3.75e-11)|Melanoma(852;1.46e-05)|all_hematologic(158;4.65e-05)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0101)|Prostate(24;0.0153)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;3.93e-06)|Epithelial(105;0.000122)|all cancers(92;0.00104)		TCACTCACATCTTGCTATAAG	0.363	Melanoma(4;162 555 7664)|GBM(79;500 2010 17506)|Esophageal Squamous(9;463 924 15765)		NA											4	23					0	0	0.009096	0	0
C3AR1	719	broad.mit.edu	37	12	8211605	8211605	+	Missense_Mutation	SNP	A	A	G			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr12:8211605A>G	uc001qtv.1	-	2	1269	c.1177T>C	c.(1177-1179)TAC>CAC	p.Y393H		NM_004054	NP_004045	Q16581	C3AR_HUMAN	complement component 3a receptor 1	393	Helical; Name=6; (Potential).				blood circulation|chemotaxis|elevation of cytosolic calcium ion concentration|inflammatory response	integral to plasma membrane	C3a anaphylatoxin receptor activity|complement component C3a receptor activity|phosphatidylinositol phospholipase C activity			ovary(1)	1				Kidney(36;0.0893)		AAAATGTGGTATGGAGTCCAG	0.512			NA											5	34					0	0	0.021553	0	0
ABCD2	225	broad.mit.edu	37	12	39947886	39947886	+	Missense_Mutation	SNP	C	C	T			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr12:39947886C>T	uc001rmb.2	-	10	2477	c.2051G>A	c.(2050-2052)CGC>CAC	p.R684H		NM_005164	NP_005155	Q9UBJ2	ABCD2_HUMAN	ATP-binding cassette, sub-family D, member 2	684	ABC transporter.				fatty acid metabolic process|transport	ATP-binding cassette (ABC) transporter complex|integral to plasma membrane|peroxisomal membrane	ATP binding|ATPase activity|protein binding			ovary(2)|upper_aerodigestive_tract(1)|pancreas(1)|central_nervous_system(1)|skin(1)	6						TTGTTCAAAGCGCCAACCTCC	0.348			NA											6	84					0	0	0.021553	0	0
MON2	23041	broad.mit.edu	37	12	62938755	62938755	+	Silent	SNP	A	A	T			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr12:62938755A>T	uc001sre.2	+	21	2935	c.2544A>T	c.(2542-2544)ACA>ACT	p.T848T	MON2_uc009zqj.2_Silent_p.T848T|MON2_uc010ssl.1_Silent_p.T776T|MON2_uc010ssm.1_Silent_p.T825T|MON2_uc010ssn.1_Silent_p.T848T|MON2_uc001srf.2_Silent_p.T611T	NM_015026	NP_055841	Q7Z3U7	MON2_HUMAN	MON2 homolog	849					Golgi to endosome transport|protein transport	cytoplasm	ARF guanyl-nucleotide exchange factor activity|binding			central_nervous_system(2)	2			BRCA - Breast invasive adenocarcinoma(9;0.218)	GBM - Glioblastoma multiforme(28;0.128)		CAGGATTAACATTTAACCATG	0.333			NA											12	51					0	0	0.020292	0	0
TMEM19	55266	broad.mit.edu	37	12	72091178	72091178	+	Nonsense_Mutation	SNP	C	C	A			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr12:72091178C>A	uc001sws.2	+	4	1084	c.501C>A	c.(499-501)TAC>TAA	p.Y167*	TMEM19_uc001swr.1_Nonsense_Mutation_p.Y153*|TMEM19_uc009zru.1_RNA	NM_018279	NP_060749	Q96HH6	TMM19_HUMAN	transmembrane protein 19	167						integral to membrane					0		Breast(359;0.0889)		GBM - Glioblastoma multiforme(134;0.044)		CCAAGCAGTACTCCGCTTCCT	0.512			NA											19	85					2.32416e-17	3.09136e-17	0.014323	1	0
NR1H4	9971	broad.mit.edu	37	12	100928726	100928726	+	Silent	SNP	T	T	C			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr12:100928726T>C	uc001tht.1	+	4	715	c.687T>C	c.(685-687)CAT>CAC	p.H229H	NR1H4_uc001thp.1_Silent_p.H215H|NR1H4_uc001thq.1_Silent_p.H219H|NR1H4_uc010svj.1_RNA|NR1H4_uc001thr.1_Silent_p.H219H|NR1H4_uc010svk.1_Silent_p.H168H|NR1H4_uc001ths.1_Silent_p.H225H	NM_005123	NP_005114	Q96RI1	NR1H4_HUMAN	nuclear receptor subfamily 1, group H, member 4	229					bile acid metabolic process|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|thyroid hormone receptor activity|transcription coactivator activity|transcription corepressor activity|zinc ion binding			ovary(1)|lung(1)|skin(1)	3						TGAAGCAGCATGCAGATCAGA	0.413			NA											13	60					0	0	0.016723	0	0
UBC	7316	broad.mit.edu	37	12	125397791	125397791	+	Missense_Mutation	SNP	T	T	G			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr12:125397791T>G	uc001ugs.3	-	2	975	c.527A>C	c.(526-528)GAG>GCG	p.E176A	UBC_uc001ugr.2_5'Flank|UBC_uc001ugu.1_Missense_Mutation_p.E176A|UBC_uc001ugt.2_Missense_Mutation_p.E176A|UBC_uc001ugv.2_Intron|UBC_uc001ugw.2_Missense_Mutation_p.E24A	NM_021009	NP_066289	P0CG48	UBC_HUMAN	ubiquitin C	176	Ubiquitin-like 3.				activation of MAPK activity|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|anti-apoptosis|apoptosis|cellular membrane organization|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA repair|endosome transport|epidermal growth factor receptor signaling pathway|G1/S transition of mitotic cell cycle|I-kappaB kinase/NF-kappaB cascade|induction of apoptosis by extracellular signals|innate immune response|JNK cascade|M/G1 transition of mitotic cell cycle|mRNA metabolic process|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of type I interferon production|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|S phase of mitotic cell cycle|stress-activated MAPK cascade|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|viral reproduction	cytosol|endocytic vesicle membrane|endosome membrane|nucleoplasm|plasma membrane	protein binding			ovary(2)	2	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;6.17e-05)|Epithelial(86;0.000207)|all cancers(50;0.00308)		CTTGACATTCTCGATGGTGTC	0.527			NA											10	142					0	0	0.020292	0	0
ZNF10	7556	broad.mit.edu	37	12	133727632	133727632	+	Missense_Mutation	SNP	G	G	T			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr12:133727632G>T	uc009zzb.2	+	3	499	c.52G>T	c.(52-54)GAT>TAT	p.D18Y	ZNF268_uc010tbv.1_5'UTR|ZNF10_uc001ulq.2_Missense_Mutation_p.D18Y	NM_015394	NP_056209	P21506	ZNF10_HUMAN	zinc finger protein 10	18	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			breast(1)|central_nervous_system(1)|skin(1)	3	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_cancers(7;1.28e-06)|all_epithelial(31;0.0051)|Lung NSC(355;0.00948)		OV - Ovarian serous cystadenocarcinoma(86;3.58e-08)|Epithelial(86;6.6e-07)|all cancers(50;2.28e-05)		GACCTTCAAGGATGTATTTGT	0.458			NA											13	81					0.000219431	0.000242436	0.020292	1	0
OLFM4	10562	broad.mit.edu	37	13	53624329	53624329	+	Missense_Mutation	SNP	G	G	A	rs144683972		TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr13:53624329G>A	uc001vhl.2	+	5	956	c.956G>A	c.(955-957)CGA>CAA	p.R319Q	OLFM4_uc001vhk.1_Intron	NM_006418	NP_006409	Q6UX06	OLFM4_HUMAN	olfactomedin 4 precursor	319	Olfactomedin-like.				cell adhesion	extracellular space				skin(1)	1		Breast(56;0.000776)|Lung NSC(96;0.000814)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;3.13e-08)		ATAAATGCTCGAGAGTTGCGG	0.433			NA											4	88					0	0	0.009096	0	0
COL4A1	1282	broad.mit.edu	37	13	110822018	110822018	+	Silent	SNP	A	A	G			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr13:110822018A>G	uc001vqw.3	-	43	3956	c.3834T>C	c.(3832-3834)GGT>GGC	p.G1278G	COL4A1_uc010agl.2_Intron	NM_001845	NP_001836	P02462	CO4A1_HUMAN	alpha 1 type IV collagen preproprotein	1278	Triple-helical region.				angiogenesis|axon guidance		extracellular matrix structural constituent|platelet-derived growth factor binding			ovary(3)|lung(1)|central_nervous_system(1)|pancreas(1)	6	all_cancers(4;9.8e-13)|all_epithelial(4;9.66e-08)|all_lung(23;3.75e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00178)|all_neural(89;0.00459)|Medulloblastoma(90;0.00596)|Lung SC(71;0.0604)	Breast(118;0.2)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.145)			GCCCTGGGACACCGGGTGCTC	0.512			NA											15	81					0	0	0.043863	0	0
FITM1	161247	broad.mit.edu	37	14	24600930	24600930	+	Missense_Mutation	SNP	G	G	C			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr14:24600930G>C	uc001wmf.2	+	1	256	c.158G>C	c.(157-159)CGG>CCG	p.R53P		NM_203402	NP_981947	A5D6W6	FITM1_HUMAN	fat-inducing transcript 1	53	Extracellular (Potential).				lipid particle organization|positive regulation of sequestering of triglyceride	endoplasmic reticulum membrane|integral to membrane					0						CCCTGCTTACGGCGCCTCTAC	0.627			NA											4	42					0	0	0.009096	0	0
RIPK3	11035	broad.mit.edu	37	14	24808294	24808294	+	Missense_Mutation	SNP	T	T	A			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr14:24808294T>A	uc001wpb.2	-	3	608	c.398A>T	c.(397-399)GAC>GTC	p.D133V	RIPK3_uc001wpa.2_5'Flank|RIPK3_uc010alq.2_RNA|RIPK3_uc010toi.1_5'UTR|RIPK3_uc010toj.1_Missense_Mutation_p.D133V	NM_006871	NP_006862	Q9Y572	RIPK3_HUMAN	receptor-interacting serine-threonine kinase 3	133	Protein kinase.				apoptosis|induction of apoptosis by extracellular signals	cytoplasm	ATP binding|protein binding|transcription coactivator activity			central_nervous_system(2)|ovary(1)|lung(1)	4				GBM - Glioblastoma multiforme(265;0.0181)		CGGGTTCTGGTCGTGCAGGTA	0.637	Pancreas(58;918 1191 4668 13304 15331)		NA											5	50					0	0	0.014758	0	0
ARID4A	5926	broad.mit.edu	37	14	58831476	58831476	+	Missense_Mutation	SNP	T	T	C			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr14:58831476T>C	uc001xdp.2	+	20	2923	c.2669T>C	c.(2668-2670)ATT>ACT	p.I890T	ARID4A_uc001xdo.2_Missense_Mutation_p.I890T|ARID4A_uc001xdq.2_Missense_Mutation_p.I890T|ARID4A_uc010apg.1_Missense_Mutation_p.I568T	NM_002892	NP_002883	P29374	ARI4A_HUMAN	retinoblastoma-binding protein 1 isoform I	890					negative regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	transcriptional repressor complex	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(3)|skin(2)|lung(1)	6						AGTGATTGTATTGGATCTGAG	0.353			NA											3	38					0	0	0.009096	0	0
SPG11	80208	broad.mit.edu	37	15	44955626	44955627	+	Missense_Mutation	DNP	CC	CC	AA			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr15:44955626_44955627CC>AA	uc001ztx.2	-	1	250_251	c.219_220GG>TT	c.(217-222)CGGGGC>CGTTGC	p.G74C	SPG11_uc010ueh.1_Missense_Mutation_p.G74C|SPG11_uc010uei.1_Missense_Mutation_p.G74C|SPG11_uc001zua.1_Missense_Mutation_p.G74C	NM_025137	NP_079413	Q96JI7	SPTCS_HUMAN	spatacsin isoform 1	74	Extracellular (Potential).				cell death	cytosol|integral to membrane|nucleus	protein binding			ovary(4)|skin(1)	5		all_cancers(109;1.29e-14)|all_epithelial(112;1.26e-12)|Lung NSC(122;1.34e-07)|all_lung(180;1.21e-06)|Melanoma(134;0.0122)		all cancers(107;2.93e-22)|GBM - Glioblastoma multiforme(94;1.55e-06)|COAD - Colon adenocarcinoma(120;0.0432)|Colorectal(105;0.0484)|Lung(196;0.104)|LUSC - Lung squamous cell carcinoma(244;0.214)		CGACCCCCGCCCCGGCTGCCAG	0.698			NA											3	10					0	0	0.004672	0	0
FANCI	55215	broad.mit.edu	37	15	89811675	89811676	+	Nonsense_Mutation	DNP	GG	GG	CT			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr15:89811675_89811676GG>CT	uc010bnp.1	+	10	891_892	c.801_802GG>CT	c.(799-804)GTGGAA>GTCTAA	p.E268*	FANCI_uc002bnm.1_Nonsense_Mutation_p.E268*|FANCI_uc002bnn.1_RNA|FANCI_uc002bnp.1_Nonsense_Mutation_p.E89*	NM_001113378	NP_001106849	Q9NVI1	FANCI_HUMAN	Fanconi anemia, complementation group I isoform	268					cell cycle|DNA repair	nucleoplasm	protein binding			ovary(2)	2	Lung NSC(78;0.0472)|all_lung(78;0.089)					TTCGTCATGTGGAAGGCACCAT	0.351			NA						Direct_reversal_of_damage|Involved_in_tolerance_or_repair_of_DNA_crosslinks	FanconAnemia				18	150					0	0	0.004672	0	0
SPATA8	145946	broad.mit.edu	37	15	97327418	97327418	+	Missense_Mutation	SNP	G	G	T			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr15:97327418G>T	uc002bue.2	+	2	335	c.125G>T	c.(124-126)TGT>TTT	p.C42F	uc010urp.1_5'Flank|uc002bud.1_5'Flank	NM_173499	NP_775770	Q6RVD6	SPAT8_HUMAN	spermatogenesis associated 8	42										ovary(1)|skin(1)	2	Melanoma(26;0.0142)|Lung NSC(78;0.041)|all_lung(78;0.0468)		OV - Ovarian serous cystadenocarcinoma(32;0.0718)			GCCATGACATGTCCCTGCGGC	0.592			NA											12	67					9.31168e-06	1.09974e-05	0.016723	1	0
TPSAB1	7177	broad.mit.edu	37	16	1291189	1291189	+	Missense_Mutation	SNP	G	G	A	rs143010092		TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr16:1291189G>A	uc002ckz.2	+	3	149	c.97G>A	c.(97-99)GGG>AGG	p.G33R	TPSAB1_uc010uux.1_5'UTR	NM_003294	NP_003285	Q15661	TRYB1_HUMAN	tryptase alpha/beta 1 precursor	33	Peptidase S1.				defense response|proteolysis	extracellular space	protein binding|serine-type endopeptidase activity				0		Hepatocellular(780;0.00369)				GGGCATCGTCGGGGGTCAGGA	0.701			NA											4	44					0	0	0.02938	0	0
TPSAB1	7177	broad.mit.edu	37	16	1291244	1291244	+	Missense_Mutation	SNP	A	A	G	rs150845192		TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr16:1291244A>G	uc002ckz.2	+	3	204	c.152A>G	c.(151-153)CAC>CGC	p.H51R	TPSAB1_uc010uux.1_5'UTR	NM_003294	NP_003285	Q15661	TRYB1_HUMAN	tryptase alpha/beta 1 precursor	51	Peptidase S1.				defense response|proteolysis	extracellular space	protein binding|serine-type endopeptidase activity				0		Hepatocellular(780;0.00369)				CTGAGAGTCCACGGCCCATAC	0.711			NA											5	71					0	0	0.008291	0	0
MAPK8IP3	23162	broad.mit.edu	37	16	1798647	1798647	+	Missense_Mutation	SNP	A	A	G			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr16:1798647A>G	uc002cmk.2	+	8	1259	c.1139A>G	c.(1138-1140)GAC>GGC	p.D380G	MAPK8IP3_uc002cml.2_Missense_Mutation_p.D380G|MAPK8IP3_uc010uvl.1_Missense_Mutation_p.D381G	NM_015133	NP_055948	Q9UPT6	JIP3_HUMAN	mitogen-activated protein kinase 8 interacting	380					vesicle-mediated transport	Golgi membrane	kinesin binding|MAP-kinase scaffold activity|protein kinase binding			breast(2)|central_nervous_system(1)	3						ATCAACACCGACTCCCTGTAC	0.627			NA											5	36					0	0	0.021553	0	0
PRSS22	64063	broad.mit.edu	37	16	2906186	2906186	+	Nonsense_Mutation	SNP	C	C	A			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr16:2906186C>A	uc002cry.1	-	3	244	c.178G>T	c.(178-180)GAG>TAG	p.E60*	PRSS22_uc002crz.1_Nonsense_Mutation_p.E60*	NM_022119	NP_071402	Q9GZN4	BSSP4_HUMAN	protease, serine, 22 precursor	60	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			central_nervous_system(1)	1						CAGGGCCACTCGCTGTCAGTG	0.602			NA											10	47					0.00829132	0.00867107	0.008291	1	0
CHD3	1107	broad.mit.edu	37	17	7809897	7809897	+	Missense_Mutation	SNP	A	A	G			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr17:7809897A>G	uc002gje.2	+	29	4535	c.4385A>G	c.(4384-4386)CAT>CGT	p.H1462R	CHD3_uc002gjd.2_Missense_Mutation_p.H1521R|CHD3_uc002gjf.2_Missense_Mutation_p.H1462R|CHD3_uc002gjh.2_Missense_Mutation_p.H38R|CHD3_uc002gjj.2_5'Flank	NM_001005273	NP_001005273	Q12873	CHD3_HUMAN	chromodomain helicase DNA binding protein 3	1462					chromatin modification|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	microtubule organizing center|NuRD complex	ATP binding|ATP-dependent DNA helicase activity|DNA binding|protein binding|zinc ion binding			breast(1)	1		Prostate(122;0.202)				TTCATGCGCCATCTGTGTGAG	0.612			NA											12	82					0	0	0.020292	0	0
C17orf103	256302	broad.mit.edu	37	17	21146727	21146727	+	Missense_Mutation	SNP	C	C	T			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr17:21146727C>T	uc010vzx.1	-	4	243	c.241G>A	c.(241-243)GTG>ATG	p.V81M		NM_152914	NP_690878	Q8N6N6	GTL3B_HUMAN	transcript expressed during hematopoiesis 2	81											0						TCCTCCACCACGAAGTCCAGG	0.657			NA											4	38					0	0	0.009096	0	0
KRT31	3881	broad.mit.edu	37	17	39552755	39552755	+	Missense_Mutation	SNP	G	G	C			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr17:39552755G>C	uc002hwn.2	-	3	558	c.505C>G	c.(505-507)CTG>GTG	p.L169V	KRT31_uc010cxn.2_Missense_Mutation_p.L169V	NM_002277	NP_002268	Q15323	K1H1_HUMAN	keratin 31	169	Rod.|Coil 1B.				epidermis development	intermediate filament	protein binding|structural constituent of cytoskeleton				0		Breast(137;0.000496)				CACAGGGTCAGCTCATCCAGG	0.597			NA											6	54					0	0	0.038147	0	0
KRT35	3886	broad.mit.edu	37	17	39636983	39636983	+	Missense_Mutation	SNP	C	C	A			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr17:39636983C>A	uc002hws.2	-	1	410	c.367G>T	c.(367-369)GCC>TCC	p.A123S		NM_002280	NP_002271	Q92764	KRT35_HUMAN	keratin 35	123	Rod.|Coil 1A.				anatomical structure morphogenesis	intermediate filament	protein binding|structural molecule activity			ovary(1)|skin(1)	2		Breast(137;0.000286)				TCCAGGCTGGCGTTCTCCTGC	0.612			NA											7	97					0.000157383	0.000175297	0.038147	1	0
BRCA1	672	broad.mit.edu	37	17	41245544	41245544	+	Silent	SNP	G	G	A			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr17:41245544G>A	uc002icq.2	-	10	2236	c.2004C>T	c.(2002-2004)CTC>CTT	p.L668L	BRCA1_uc010whp.1_Intron|BRCA1_uc010whl.1_Intron|BRCA1_uc010whm.1_Intron|BRCA1_uc002icp.3_Silent_p.L597L|BRCA1_uc002icu.2_Intron|BRCA1_uc010cyx.2_Silent_p.L621L|BRCA1_uc002ict.2_Silent_p.L668L|BRCA1_uc010whn.1_Intron|BRCA1_uc010who.1_Intron|BRCA1_uc010whq.1_Intron|BRCA1_uc002idc.1_Intron|BRCA1_uc010whr.1_Intron|BRCA1_uc002idd.2_Silent_p.L668L|BRCA1_uc002ide.1_Silent_p.L499L|BRCA1_uc010cyy.1_Silent_p.L668L|BRCA1_uc010whs.1_Silent_p.L668L|BRCA1_uc010cyz.2_Silent_p.L621L|BRCA1_uc010cza.2_Silent_p.L642L|BRCA1_uc010wht.1_Silent_p.L372L	NM_007294	NP_009225	P38398	BRCA1_HUMAN	breast cancer 1, early onset isoform 1	668					androgen receptor signaling pathway|apoptosis|cellular response to indole-3-methanol|chromosome segregation|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|DNA damage response, signal transduction resulting in induction of apoptosis|double-strand break repair via homologous recombination|fatty acid biosynthetic process|G2/M transition DNA damage checkpoint|negative regulation of centriole replication|negative regulation of fatty acid biosynthetic process|negative regulation of histone H3-K9 methylation|negative regulation of transcription, DNA-dependent|positive regulation of cell cycle arrest|positive regulation of DNA repair|positive regulation of histone acetylation|positive regulation of histone H3-K4 methylation|positive regulation of histone H4-K20 methylation|positive regulation of protein ubiquitination|positive regulation of transcription from RNA polymerase II promoter|postreplication repair|protein autoubiquitination|protein K6-linked ubiquitination|regulation of cell motility|regulation of cell proliferation|regulation of transcription from RNA polymerase III promoter|response to estrogen stimulus|response to ionizing radiation|substrate adhesion-dependent cell spreading	BRCA1-A complex|BRCA1-BARD1 complex|gamma-tubulin ring complex|nucleoplasm|plasma membrane|ribonucleoprotein complex|ruffle	androgen receptor binding|identical protein binding|protein binding|RNA binding|transcription coactivator activity|transcription regulatory region DNA binding|tubulin binding|ubiquitin protein ligase binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(24)|breast(21)|lung(4)|central_nervous_system(1)|endometrium(1)|urinary_tract(1)	52		Breast(137;0.000717)		BRCA - Breast invasive adenocarcinoma(366;0.126)		TACCTTCCATGAGTTGTAGGT	0.398			NA	D|Mis|N|F|S		ovarian	breast|ovarian		Homologous_recombination	Hereditary_Breast-Ovarian_Cancer_BRCA1_type	TCGA Ovarian(2;0.000030)			13	93					0	0	0.016723	0	0
CACNG4	27092	broad.mit.edu	37	17	65021068	65021068	+	Missense_Mutation	SNP	C	C	A			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr17:65021068C>A	uc002jft.1	+	3	412	c.397C>A	c.(397-399)CGC>AGC	p.R133S		NM_014405	NP_055220	Q9UBN1	CCG4_HUMAN	voltage-dependent calcium channel gamma-4	133	Cytoplasmic (Potential).				membrane depolarization|regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|endocytic vesicle membrane	voltage-gated calcium channel activity			central_nervous_system(1)	1	all_cancers(12;9.86e-11)		BRCA - Breast invasive adenocarcinoma(6;1.35e-07)			GATCTACAGCCGCAAGAACAA	0.672			NA											4	75					0.000602214	0.000644558	0.014758	1	0
SLC25A10	1468	broad.mit.edu	37	17	79682037	79682037	+	Missense_Mutation	SNP	C	C	T			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr17:79682037C>T	uc002kbi.2	+	2	234	c.148C>T	c.(148-150)CGG>TGG	p.R50W	SLC25A10_uc010wut.1_Missense_Mutation_p.R205W|SLC25A10_uc010dif.2_Missense_Mutation_p.R50W|SLC25A10_uc010wuu.1_Missense_Mutation_p.R4W	NM_012140	NP_036272	Q9UBX3	DIC_HUMAN	solute carrier family 25 (mitochondrial carrier;	50	Solcar 1.				gluconeogenesis|mitochondrial transport	integral to membrane|mitochondrial inner membrane|nucleus	protein binding				0	all_neural(118;0.0878)|Ovarian(332;0.12)|all_lung(278;0.23)		BRCA - Breast invasive adenocarcinoma(99;0.0117)|OV - Ovarian serous cystadenocarcinoma(97;0.0955)		Succinic acid(DB00139)	CATGGCGCTGCGGGTGGTGCG	0.667			NA											8	32					0	0	0.004482	0	0
SLC39A6	25800	broad.mit.edu	37	18	33694106	33694106	+	Silent	SNP	C	C	A			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr18:33694106C>A	uc010dmy.2	-	7	2087	c.1797G>T	c.(1795-1797)GTG>GTT	p.V599V	SLC39A6_uc002kzj.2_Silent_p.V324V	NM_012319	NP_036451	Q13433	S39A6_HUMAN	solute carrier family 39 (zinc transporter),	599	Cytoplasmic (Potential).					integral to membrane|lamellipodium membrane	zinc ion transmembrane transporter activity			ovary(1)|pancreas(1)	2						CACCCATTATCACCATCCAGG	0.343			NA											5	60					3.59834e-05	4.1081e-05	0.021553	1	0
XAB2	56949	broad.mit.edu	37	19	7691039	7691039	+	Missense_Mutation	SNP	C	C	T			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr19:7691039C>T	uc002mgx.2	-	5	666	c.640G>A	c.(640-642)GGC>AGC	p.G214S		NM_020196	NP_064581	Q9HCS7	SYF1_HUMAN	XPA binding protein 2	214	HAT 6.				transcription, DNA-dependent|transcription-coupled nucleotide-excision repair	catalytic step 2 spliceosome|nucleoplasm	protein binding			central_nervous_system(2)|breast(1)|skin(1)	4						TTGGACTTGCCGGCCTTAGAC	0.642			NA						Direct_reversal_of_damage|NER					3	108					0	0	0.004672	0	0
S1PR2	9294	broad.mit.edu	37	19	10334757	10334757	+	Silent	SNP	G	G	A			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr19:10334757G>A	uc002mnl.2	-	2	936	c.825C>T	c.(823-825)GCC>GCT	p.A275A		NM_004230	NP_004221	O95136	S1PR2_HUMAN	endothelial differentiation, sphingolipid	275	Helical; Name=7; (By similarity).				activation of MAPK activity|positive regulation of cell proliferation	integral to membrane|plasma membrane	lipid binding|lysosphingolipid and lysophosphatidic acid receptor activity			lung(1)|central_nervous_system(1)	2						GGGTGGAGACGGCGAAAAAGT	0.632	Pancreas(194;229 3020 15179 45747)		NA											5	28					0	0	0.021553	0	0
SMARCA4	6597	broad.mit.edu	37	19	11100015	11100015	+	Nonsense_Mutation	SNP	C	C	T			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr19:11100015C>T	uc002mqf.3	+	7	1425	c.1141C>T	c.(1141-1143)CGA>TGA	p.R381*	SMARCA4_uc010dxp.2_Nonsense_Mutation_p.R381*|SMARCA4_uc010dxo.2_Nonsense_Mutation_p.R381*|SMARCA4_uc002mqg.1_Nonsense_Mutation_p.R381*|SMARCA4_uc010dxq.2_Nonsense_Mutation_p.R381*|SMARCA4_uc010dxr.2_Nonsense_Mutation_p.R381*|SMARCA4_uc002mqj.3_Nonsense_Mutation_p.R381*|SMARCA4_uc010dxs.2_Nonsense_Mutation_p.R381*|SMARCA4_uc002mqe.2_Nonsense_Mutation_p.R381*	NM_003072	NP_003063	P51532	SMCA4_HUMAN	SWI/SNF-related matrix-associated	381					chromatin remodeling|negative regulation of androgen receptor signaling pathway|negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|negative regulation of transcription from RNA polymerase II promoter|nervous system development|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nBAF complex|npBAF complex|nuclear chromatin|SWI/SNF complex|WINAC complex	androgen receptor binding|ATP binding|DNA binding|DNA-dependent ATPase activity|helicase activity|histone acetyl-lysine binding|identical protein binding|p53 binding|protein N-terminus binding|transcription corepressor activity	p.?(1)		lung(29)|ovary(8)|pancreas(7)|large_intestine(5)|central_nervous_system(5)|skin(3)|prostate(3)|breast(2)|adrenal_gland(1)|stomach(1)|liver(1)|autonomic_ganglia(1)|kidney(1)	67		all_lung(6;0.0512)|Lung NSC(9;0.0568)				CATCGCACACCGAATTCAGGA	0.607			NA	F|N|Mis		NSCLC				Rhabdoid_Predisposition_syndrome				19	85					0	0	0.008871	0	0
CPAMD8	27151	broad.mit.edu	37	19	17058020	17058020	+	Silent	SNP	C	C	T			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr19:17058020C>T	uc002nfb.2	-	21	2699	c.2667G>A	c.(2665-2667)TCG>TCA	p.S889S		NM_015692	NP_056507	Q8IZJ3	CPMD8_HUMAN	C3 and PZP-like, alpha-2-macroglobulin domain	842						extracellular space|plasma membrane	serine-type endopeptidase inhibitor activity			ovary(4)|breast(4)|large_intestine(3)|pancreas(1)|skin(1)	13						CCTTGGGAACCGAGAGCTTCA	0.607			NA											12	132					0	0	0.016723	0	0
HOMER3	9454	broad.mit.edu	37	19	19042357	19042357	+	Silent	SNP	C	C	T			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr19:19042357C>T	uc002nku.2	-	7	1421	c.768G>A	c.(766-768)TCG>TCA	p.S256S	HOMER3_uc002nko.1_RNA|HOMER3_uc002nkp.1_RNA|HOMER3_uc010eby.2_Silent_p.S220S|HOMER3_uc010ebz.2_Silent_p.S256S|HOMER3_uc002nkw.2_Silent_p.S256S|HOMER3_uc002nkv.2_Silent_p.S256S	NM_004838	NP_004829	Q9NSC5	HOME3_HUMAN	Homer, neuronal immediate early gene, 3 isoform	256	Potential.				metabotropic glutamate receptor signaling pathway|protein targeting	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	protein binding				0			Epithelial(12;0.0107)			GCTGTTCCAGCGACTGGCCCT	0.637			NA											5	100					0	0	0.014758	0	0
ZNF486	90649	broad.mit.edu	37	19	20308637	20308637	+	Missense_Mutation	SNP	C	C	T			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr19:20308637C>T	uc002nou.2	+	4	1175	c.1118C>T	c.(1117-1119)ACT>ATT	p.T373I		NM_052852	NP_443084	Q96H40	ZN486_HUMAN	zinc finger protein 486	373					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						ATAATTCATACTGGAGAGAAA	0.433			NA											8	49					0	0	0.004482	0	0
CCNE1	898	broad.mit.edu	37	19	30312666	30312666	+	Missense_Mutation	SNP	T	T	A			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr19:30312666T>A	uc002nsn.2	+	8	830	c.647T>A	c.(646-648)GTG>GAG	p.V216E	CCNE1_uc002nso.2_Missense_Mutation_p.V201E|CCNE1_uc002nsp.2_5'UTR	NM_001238	NP_001229	P24864	CCNE1_HUMAN	cyclin E1 isoform 1	216					androgen receptor signaling pathway|cell division|positive regulation of transcription, DNA-dependent|regulation of cyclin-dependent protein kinase activity|regulation of transcription involved in G1/S phase of mitotic cell cycle	cytosol|nucleoplasm	androgen receptor binding|protein kinase binding|transcription coactivator activity			lung(2)	2	all_cancers(1;2.19e-31)|all_epithelial(1;1.49e-30)|all_lung(1;1.37e-11)|Lung NSC(1;2.35e-11)|Ovarian(5;0.000902)|Breast(6;0.0203)|Esophageal squamous(110;0.195)		UCEC - Uterine corpus endometrioid carcinoma (4;2.65e-06)|Epithelial(1;6.85e-98)|all cancers(1;1.38e-94)|OV - Ovarian serous cystadenocarcinoma(1;1.38e-90)|STAD - Stomach adenocarcinoma(5;5.8e-07)|GBM - Glioblastoma multiforme(4;0.0394)|Lung(7;0.092)|LUAD - Lung adenocarcinoma(5;0.115)|BRCA - Breast invasive adenocarcinoma(6;0.183)|COAD - Colon adenocarcinoma(1;0.188)|Colorectal(1;0.202)			TTTGCGTATGTGACAGATGGA	0.388			NA											6	55					0	0	0.02938	0	0
ZNF536	9745	broad.mit.edu	37	19	31025842	31025842	+	Missense_Mutation	SNP	C	C	G			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr19:31025842C>G	uc002nsu.1	+	3	2397	c.2259C>G	c.(2257-2259)TGC>TGG	p.C753W	ZNF536_uc010edd.1_Missense_Mutation_p.C753W	NM_014717	NP_055532	O15090	ZN536_HUMAN	zinc finger protein 536	753	C2H2-type 8.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(7)|large_intestine(2)|skin(2)	11	Esophageal squamous(110;0.0834)					TGAAGGACTGCCCGTACTGTG	0.602			NA											8	124					0	0	0.038147	0	0
FCGBP	8857	broad.mit.edu	37	19	40408275	40408275	+	Missense_Mutation	SNP	A	A	T			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr19:40408275A>T	uc002omp.3	-	8	4572	c.4564T>A	c.(4564-4566)TGG>AGG	p.W1522R		NM_003890	NP_003881	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein precursor	1522						extracellular region	protein binding			ovary(4)|skin(4)|central_nervous_system(1)	9	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			TCAGTCCTCCAGGGCTCCACG	0.622			NA											44	54					0	0	0.036044	0	0
ZNF155	7711	broad.mit.edu	37	19	44495759	44495760	+	Missense_Mutation	DNP	GG	GG	AA			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr19:44495759_44495760GG>AA	uc002oxy.1	+	3	280_281	c.75_76GG>AA	c.(73-78)CTGGAC>CTAAAC	p.D26N	ZNF155_uc002oxz.1_Missense_Mutation_p.D26N|ZNF155_uc010xwt.1_Missense_Mutation_p.D37N	NM_003445	NP_003436	Q12901	ZN155_HUMAN	zinc finger protein 155	26	KRAB.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			large_intestine(1)|ovary(1)	2		Prostate(69;0.0352)				TGGGGCTGCTGGACCCTGCCCA	0.52	NSCLC(61;554 1277 20909 42067 42312)		NA											54	180					0	0	0.004672	0	0
ZNF223	7766	broad.mit.edu	37	19	44570427	44570427	+	Missense_Mutation	SNP	A	A	G			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr19:44570427A>G	uc002oyf.1	+	5	699	c.446A>G	c.(445-447)AAT>AGT	p.N149S	ZNF284_uc010ejd.2_RNA	NM_013361	NP_037493	Q9UK11	ZN223_HUMAN	zinc finger protein 223	149					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Prostate(69;0.0352)				AAACCTTCCAATTGTGGGAAG	0.448			NA											4	150					0	0	0.009096	0	0
C5AR1	728	broad.mit.edu	37	19	47823129	47823129	+	Missense_Mutation	SNP	C	C	T			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr19:47823129C>T	uc002pgj.1	+	2	144	c.95C>T	c.(94-96)ACG>ATG	p.T32M		NM_001736	NP_001727	P21730	C5AR_HUMAN	complement component 5 receptor 1	32	Extracellular (Potential).				activation of MAPK activity|activation of phospholipase C activity|cellular defense response|elevation of cytosolic calcium ion concentration|immune response|sensory perception of chemical stimulus	integral to plasma membrane	C5a anaphylatoxin receptor activity			ovary(2)|central_nervous_system(1)|skin(1)	4		all_cancers(25;2e-09)|all_epithelial(76;9.95e-08)|all_lung(116;7.27e-07)|Lung NSC(112;1.6e-06)|Ovarian(192;0.0139)|all_neural(266;0.026)|Breast(70;0.0503)		all cancers(93;0.000267)|OV - Ovarian serous cystadenocarcinoma(262;0.000618)|Epithelial(262;0.0142)|GBM - Glioblastoma multiforme(486;0.0242)		ACTTCTAACACGCTGCGTGTT	0.532			NA											11	48					0	0	0.008291	0	0
LRRC4B	94030	broad.mit.edu	37	19	51022162	51022162	+	Missense_Mutation	SNP	G	G	A			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr19:51022162G>A	uc002pss.2	-	3	945	c.808C>T	c.(808-810)CGC>TGC	p.R270C		NM_001080457	NP_001073926	Q9NT99	LRC4B_HUMAN	leucine rich repeat containing 4B precursor	270	Extracellular (Potential).|LRR 8.					cell junction|integral to membrane|presynaptic membrane				central_nervous_system(1)|skin(1)	2		all_neural(266;0.131)		OV - Ovarian serous cystadenocarcinoma(262;0.00284)|GBM - Glioblastoma multiforme(134;0.0188)		AAGGCGTTGCGCTCGATGGTG	0.657			NA											15	56					0	0	0.0333	0	0
SIGLEC14	100049587	broad.mit.edu	37	19	52148735	52148735	+	Missense_Mutation	SNP	C	C	A			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr19:52148735C>A	uc002pxf.3	-	4	869	c.749G>T	c.(748-750)GGC>GTC	p.G250V		NM_001098612	NP_001092082	Q08ET2	SIG14_HUMAN	sialic acid binding Ig-like lectin 14 precursor	250	Extracellular (Potential).|Ig-like C2-type 2.				cell adhesion	integral to membrane|plasma membrane	protein binding|sugar binding			ovary(1)	1		all_neural(266;0.0299)		GBM - Glioblastoma multiforme(134;0.000965)|OV - Ovarian serous cystadenocarcinoma(262;0.0195)		CCTACCTGTGCCTGTGCCATT	0.552			NA											8	27					0.00448238	0.00472374	0.004482	1	0
TTYH1	57348	broad.mit.edu	37	19	54937858	54937858	+	Missense_Mutation	SNP	C	C	T			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr19:54937858C>T	uc002qfq.2	+	5	739	c.647C>T	c.(646-648)GCC>GTC	p.A216V	TTYH1_uc010yey.1_Missense_Mutation_p.A265V|TTYH1_uc002qfr.2_Missense_Mutation_p.A216V|TTYH1_uc002qft.2_Missense_Mutation_p.A216V|TTYH1_uc002qfu.1_Missense_Mutation_p.A128V	NM_020659	NP_065710	Q9H313	TTYH1_HUMAN	tweety 1 isoform 1	216	Helical; Name=3; (Potential).				cell adhesion	chloride channel complex|plasma membrane	chloride channel activity|iron ion transmembrane transporter activity				0	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.0767)		AGGTGGCTGGCCTACGTCCTC	0.647			NA											9	88					0	0	0.010729	0	0
ZNF814	730051	broad.mit.edu	37	19	58385546	58385546	+	Missense_Mutation	SNP	G	G	T			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr19:58385546G>T	uc002qqo.2	-	3	1484	c.1212C>A	c.(1210-1212)GAC>GAA	p.D404E	ZNF814_uc002qqk.2_Intron|ZNF814_uc010yhl.1_Intron	NM_001144989	NP_001138461	B7Z6K7	ZN814_HUMAN	zinc finger protein 814	404					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding				0						AATGTTTTTTGTCAGTGTGAA	0.393			NA											4	20					2.56e-06	3.07649e-06	0.009096	1	0
C2orf70	339778	broad.mit.edu	37	2	26802211	26802211	+	Missense_Mutation	SNP	G	G	A	rs147381361	by1000genomes	TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr2:26802211G>A	uc010eyn.2	+	4	511	c.511G>A	c.(511-513)GAG>AAG	p.E171K		NM_001105519	NP_001098989	A6NJV1	CB070_HUMAN	hypothetical protein LOC339778	171										skin(1)	1						ACTAGCCCCCGAGAACCTGAA	0.532			NA											13	46					0	0	0.016723	0	0
AUP1	550	broad.mit.edu	37	2	74755588	74755588	+	Missense_Mutation	SNP	C	C	T			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr2:74755588C>T	uc010yrx.1	-	4	850	c.724G>A	c.(724-726)GTA>ATA	p.V242I	DQX1_uc010yrw.1_5'Flank|AUP1_uc002sme.2_5'Flank|AUP1_uc002smf.2_Missense_Mutation_p.V185I|AUP1_uc002smg.2_RNA|AUP1_uc002smh.2_Missense_Mutation_p.V94I|HTRA2_uc002smi.1_5'Flank|HTRA2_uc002smj.1_5'Flank|HTRA2_uc002smk.1_5'Flank|HTRA2_uc002sml.1_5'Flank|HTRA2_uc002smm.1_5'Flank|HTRA2_uc002smn.1_5'Flank|HTRA2_uc010ffl.2_5'Flank			Q9Y679	AUP1_HUMAN	SubName: Full=cDNA FLJ57204, highly similar to Homo sapiens ancient ubiquitous protein 1 (AUP1), transcript variant 2, mRNA;	251	Cytoplasmic (Potential).					endoplasmic reticulum membrane|integral to membrane|nucleus	protein binding				0						AGAGGTTGTACCACATCTTGG	0.502			NA											7	32					0	0	0.02938	0	0
KCNH7	90134	broad.mit.edu	37	2	163291819	163291819	+	Missense_Mutation	SNP	C	C	A			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr2:163291819C>A	uc002uch.1	-	8	2055	c.1843G>T	c.(1843-1845)GTC>TTC	p.V615F	KCNH7_uc002uci.2_Missense_Mutation_p.V608F	NM_033272	NP_150375	Q9NS40	KCNH7_HUMAN	potassium voltage-gated channel, subfamily H,	615					regulation of transcription, DNA-dependent	integral to membrane	protein binding|signal transducer activity			ovary(3)|skin(2)	5					Ibutilide(DB00308)	AGTGCTGTGACGTATTTGTCT	0.398	GBM(196;1492 2208 17507 24132 45496)		NA											10	80					2.17888e-05	2.55133e-05	0.006214	1	0
HECW2	57520	broad.mit.edu	37	2	197298051	197298051	+	Missense_Mutation	SNP	C	C	T	rs151108819	byFrequency	TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr2:197298051C>T	uc002utm.1	-	2	280	c.97G>A	c.(97-99)GCC>ACC	p.A33T		NM_020760	NP_065811	Q9P2P5	HECW2_HUMAN	HECT, C2 and WW domain containing E3 ubiquitin	33					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm	ubiquitin-protein ligase activity			skin(5)|ovary(5)|lung(4)|pancreas(2)|central_nervous_system(1)|kidney(1)	18						GAGCTCTGGGCGGCAAGGCTC	0.597			NA											9	46					0	0	0.006214	0	0
STK11IP	114790	broad.mit.edu	37	2	220476447	220476447	+	Silent	SNP	C	C	T			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr2:220476447C>T	uc002vml.2	+	18	2302	c.2259C>T	c.(2257-2259)GCC>GCT	p.A753A		NM_052902	NP_443134	Q8N1F8	S11IP_HUMAN	LKB1 interacting protein	753					protein localization	cytoplasm	protein kinase binding			ovary(1)	1		Renal(207;0.0183)		Epithelial(149;2.69e-07)|all cancers(144;5.91e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		CTCCGTCTGCCAGCCCTGTCT	0.627			NA											4	49					0	0	0.009096	0	0
SIGLEC1	6614	broad.mit.edu	37	20	3686514	3686514	+	Missense_Mutation	SNP	C	C	T	rs111336308	by1000genomes	TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr20:3686514C>T	uc002wja.2	-	3	583	c.583G>A	c.(583-585)GGC>AGC	p.G195S	SIGLEC1_uc002wiz.3_Missense_Mutation_p.G195S|SIGLEC1_uc002wjc.2_Missense_Mutation_p.G106S	NM_023068	NP_075556	Q9BZZ2	SN_HUMAN	sialoadhesin precursor	195	Ig-like C2-type 1.|Extracellular (Potential).				cell-cell adhesion|cell-matrix adhesion|endocytosis|inflammatory response	extracellular region|integral to membrane|plasma membrane	sugar binding			pancreas(4)|ovary(2)|skin(2)|breast(1)|central_nervous_system(1)	10						TGGCCGACGCCGGTGGGCTCA	0.642			NA											14	105					0	0	0.024245	0	0
CD93	22918	broad.mit.edu	37	20	23065344	23065344	+	Missense_Mutation	SNP	G	G	T	rs148539804		TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr20:23065344G>T	uc002wsv.2	-	1	1634	c.1486C>A	c.(1486-1488)CGT>AGT	p.R496S		NM_012072	NP_036204	Q9NPY3	C1QR1_HUMAN	CD93 antigen precursor	496	Extracellular (Potential).			R -> Q (in Ref. 1; AA sequence).	cell-cell adhesion|interspecies interaction between organisms|macrophage activation|phagocytosis	plasma membrane	calcium ion binding|complement component C1q binding|receptor activity|sugar binding			large_intestine(2)	2	Colorectal(13;0.0352)|Lung NSC(19;0.0542)|all_lung(19;0.118)					GTTGCAGCACGGGGCACGGTG	0.622			NA											10	51					1.08611e-07	1.34051e-07	0.010729	1	0
TMPRSS15	5651	broad.mit.edu	37	21	19653418	19653418	+	Missense_Mutation	SNP	A	A	T			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr21:19653418A>T	uc002ykw.2	-	22	2638	c.2607T>A	c.(2605-2607)AAT>AAA	p.N869K		NM_002772	NP_002763	P98073	ENTK_HUMAN	enterokinase precursor	869	Extracellular (Potential).|Peptidase S1.				proteolysis	brush border|integral to membrane	scavenger receptor activity|serine-type endopeptidase activity			ovary(5)|upper_aerodigestive_tract(1)|breast(1)|skin(1)	8						TTCTTCGCCTATTGTAATGAG	0.378			NA											14	163					0	0	0.024245	0	0
CDCP1	64866	broad.mit.edu	37	3	45134848	45134848	+	Silent	SNP	G	G	T			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr3:45134848G>T	uc003com.2	-	6	1683	c.1548C>A	c.(1546-1548)ACC>ACA	p.T516T		NM_022842	NP_073753	Q9H5V8	CDCP1_HUMAN	CUB domain-containing protein 1 isoform 1	516	CUB.|Extracellular (Potential).					extracellular region|integral to membrane|plasma membrane				ovary(1)|central_nervous_system(1)|skin(1)	3				BRCA - Breast invasive adenocarcinoma(193;0.00928)|KIRC - Kidney renal clear cell carcinoma(197;0.0519)|Kidney(197;0.0651)		AGGTGCGAAGGGTCACCGAGA	0.572			NA											5	84					3.59834e-05	4.1081e-05	0.021553	1	0
LRRC31	79782	broad.mit.edu	37	3	169587661	169587661	+	Splice_Site	SNP	C	C	T			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr3:169587661C>T	uc003fgc.1	-	1	13	c.-64_splice	c.e1-1		LRRC31_uc010hwp.1_Splice_Site	NM_024727	NP_079003	Q6UY01	LRC31_HUMAN	leucine rich repeat containing 31											ovary(2)|skin(1)	3	all_cancers(22;2.76e-22)|all_epithelial(15;4.73e-27)|all_lung(20;9.24e-17)|Lung NSC(18;3.85e-16)|Ovarian(172;0.000223)|Breast(254;0.197)		Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.00943)			TCTAGGATTTCTAAGAAGAAA	0.438			NA											8	19					0	0	0.038147	0	0
SDHAP2	727956	broad.mit.edu	37	3	195400728	195400728	+	Silent	SNP	A	A	G	rs12107841	by1000genomes	TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr3:195400728A>G	uc003fuw.2	+	9	1218	c.24A>G	c.(22-24)CCA>CCG	p.P8P	SDHAP2_uc011btb.1_Missense_Mutation_p.S156G|SDHAP2_uc011btc.1_RNA|SDHAP2_uc003fuv.2_RNA					SubName: Full=cDNA FLJ16373 fis, clone THYMU3000269, highly similar to Succinate dehydrogenase (ubiquinone) flavoprotein subunit, mitochondrial (EC 1.3.5.1);												0						GATTGTGCCCAGCCTGTACGC	0.587			NA											4	37					0	0	0.014758	0	0
KLHL8	57563	broad.mit.edu	37	4	88106793	88106793	+	Silent	SNP	G	G	A			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr4:88106793G>A	uc011cdb.1	-	3	760	c.375C>T	c.(373-375)GTC>GTT	p.V125V	KLHL8_uc003hql.1_Silent_p.V125V|KLHL8_uc003hqm.1_Intron|KLHL8_uc003hqn.1_Intron|KLHL8_uc010ikj.1_Intron	NM_020803	NP_065854	Q9P2G9	KLHL8_HUMAN	kelch-like 8	125	BTB.										0		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.242)		OV - Ovarian serous cystadenocarcinoma(123;0.000603)		GTGAAGAATAGACAAACTTTA	0.418			NA											5	48					0	0	0.021553	0	0
SEC24D	9871	broad.mit.edu	37	4	119736190	119736190	+	Missense_Mutation	SNP	G	G	C			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr4:119736190G>C	uc003ici.3	-	6	1066	c.794C>G	c.(793-795)CCT>CGT	p.P265R	SEC24D_uc003icj.3_Missense_Mutation_p.P266R|SEC24D_uc003icl.2_RNA|SEC24D_uc010imz.1_RNA|SEC24D_uc011cgg.1_RNA	NM_014822	NP_055637	O94855	SC24D_HUMAN	Sec24-related protein D	265	Pro-rich.				COPII vesicle coating|intracellular protein transport|post-translational protein modification|protein N-linked glycosylation via asparagine	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|Golgi membrane|perinuclear region of cytoplasm	zinc ion binding				0						TACTGGGCTAGGGATAGAGTC	0.502			NA											8	87					0	0	0.006214	0	0
GRIA2	2891	broad.mit.edu	37	4	158238861	158238861	+	Missense_Mutation	SNP	C	C	G			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr4:158238861C>G	uc003ipm.3	+	5	1177	c.718C>G	c.(718-720)CTG>GTG	p.L240V	GRIA2_uc011cit.1_Missense_Mutation_p.L193V|GRIA2_uc003ipl.3_Missense_Mutation_p.L240V|GRIA2_uc003ipk.3_Missense_Mutation_p.L193V|GRIA2_uc010iqh.1_RNA	NM_001083619	NP_001077088	P42262	GRIA2_HUMAN	glutamate receptor, ionotropic, AMPA 2 isoform 2	240	Extracellular (Potential).				synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|endocytic vesicle membrane|endoplasmic reticulum membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			central_nervous_system(3)|ovary(1)	4	all_hematologic(180;0.24)	Renal(120;0.0458)		COAD - Colon adenocarcinoma(41;0.0294)	L-Glutamic Acid(DB00142)	CATTGCAAATCTGGTAGGTGA	0.249			NA											4	32					0	0	0.014758	0	0
TAS2R1	50834	broad.mit.edu	37	5	9629646	9629646	+	Missense_Mutation	SNP	G	G	T			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr5:9629646G>T	uc003jem.1	-	1	818	c.499C>A	c.(499-501)CAA>AAA	p.Q167K		NM_019599	NP_062545	Q9NYW7	TA2R1_HUMAN	taste receptor T2R1	167	Extracellular (Potential).				chemosensory behavior|sensory perception of taste	integral to membrane	taste receptor activity			ovary(3)	3						TCTTCTTTTTGAATTGTGGCA	0.358			NA											5	52					3.59834e-05	4.1081e-05	0.021553	1	0
ADAMTS12	81792	broad.mit.edu	37	5	33891898	33891898	+	Missense_Mutation	SNP	C	C	A			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr5:33891898C>A	uc003jia.1	-	1	227	c.64G>T	c.(64-66)GGG>TGG	p.G22W	ADAMTS12_uc010iuq.1_Missense_Mutation_p.G22W|ADAMTS12_uc003jib.1_Missense_Mutation_p.G22W	NM_030955	NP_112217	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1	22					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|kidney(1)	9						CAAAGCGCCCCAAAGTTAAGG	0.498			NA								HNSCC(64;0.19)			14	106					0.000308642	0.000335587	0.024245	1	0
PCDHGA3	56112	broad.mit.edu	37	5	140725167	140725167	+	Missense_Mutation	SNP	G	G	A			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr5:140725167G>A	uc003ljm.1	+	1	1567	c.1567G>A	c.(1567-1569)GAG>AAG	p.E523K	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc010jfx.1_Missense_Mutation_p.E283K|PCDHGA3_uc011dap.1_Missense_Mutation_p.E523K	NM_018916	NP_061739	Q9Y5H0	PCDG3_HUMAN	protocadherin gamma subfamily A, 3 isoform 1	523	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTTCGACTACGAGCAATTTAG	0.562			NA											16	109					0	0	0.028581	0	0
ARHGAP26	23092	broad.mit.edu	37	5	142264928	142264928	+	Missense_Mutation	SNP	T	T	G			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr5:142264928T>G	uc011dbj.1	+	5	485	c.450T>G	c.(448-450)AAT>AAG	p.N150K	ARHGAP26_uc003lmt.2_Missense_Mutation_p.N150K|ARHGAP26_uc003lmw.2_Missense_Mutation_p.N150K	NM_015071	NP_055886	Q9UNA1	RHG26_HUMAN	GTPase regulator associated with the focal	150					actin cytoskeleton organization|filopodium assembly|nervous system development|small GTPase mediated signal transduction	cytoskeleton|cytosol|focal adhesion	cytoskeletal adaptor activity|Rho GTPase activator activity|SH3 domain binding			ovary(1)	1		all_hematologic(541;0.0416)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			AACACTTGAATTTGTCTTCCA	0.338			NA											10	43					0	0	0.013537	0	0
HAVCR2	84868	broad.mit.edu	37	5	156535979	156535979	+	Missense_Mutation	SNP	G	G	A			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr5:156535979G>A	uc003lwk.1	-	1	160	c.16C>T	c.(16-18)CCC>TCC	p.P6S	HAVCR2_uc003lwl.2_Missense_Mutation_p.P6S	NM_032782	NP_116171	Q8TDQ0	HAVR2_HUMAN	T cell immunoglobulin mucin 3 precursor	6						integral to membrane					0	Renal(175;0.00212)	Medulloblastoma(196;0.0354)|all_neural(177;0.0999)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			CAGTCAAAGGGAAGATGTGAA	0.358			NA											9	51					0	0	0.006214	0	0
RNF144B	255488	broad.mit.edu	37	6	18457500	18457500	+	Missense_Mutation	SNP	A	A	G			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr6:18457500A>G	uc003ncs.2	+	5	750	c.446A>G	c.(445-447)CAC>CGC	p.H149R		NM_182757	NP_877434	Q7Z419	R144B_HUMAN	IBR domain containing 2	149	IBR-type.				apoptosis|positive regulation of anti-apoptosis|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	integral to membrane|mitochondrial membrane	protein binding|ubiquitin-protein ligase activity|zinc ion binding				0	Ovarian(93;0.00365)|Breast(50;0.0145)	all_hematologic(90;0.0536)	OV - Ovarian serous cystadenocarcinoma(7;0.00165)|all cancers(50;0.0102)|Epithelial(50;0.0105)			CCTTCTTGCCACCTGAAATTC	0.552			NA											25	290					0	0	0.030593	0	0
TRIM10	10107	broad.mit.edu	37	6	30128630	30128630	+	Silent	SNP	G	G	T			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr6:30128630G>T	uc003npo.3	-	1	82	c.6C>A	c.(4-6)GCC>GCA	p.A2A	TRIM10_uc003npn.2_Silent_p.A2A|TRIM15_uc010jrx.2_5'Flank	NM_006778	NP_006769	Q9UDY6	TRI10_HUMAN	tripartite motif-containing 10 isoform 1	2						cytoplasm	zinc ion binding				0						AGGCAGCAGAGGCCATGCTGG	0.602			NA											5	21					1.024e-07	1.27535e-07	0.014758	1	0
C6orf138	442213	broad.mit.edu	37	6	47846983	47846983	+	Missense_Mutation	SNP	T	T	G			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr6:47846983T>G	uc011dwm.1	-	3	1631	c.1546A>C	c.(1546-1548)AGC>CGC	p.S516R	C6orf138_uc011dwn.1_Missense_Mutation_p.S280R	NM_001013732	NP_001013754	Q6ZW05	CF138_HUMAN	hypothetical protein LOC442213	533						integral to membrane	hedgehog receptor activity			central_nervous_system(1)	1						TCCTGGACGCTGCTGTTCCAG	0.488			NA											3	26					0	0	0.009096	0	0
TTK	7272	broad.mit.edu	37	6	80746194	80746194	+	Missense_Mutation	SNP	A	A	C			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr6:80746194A>C	uc003pjc.2	+	17	2001	c.1927A>C	c.(1927-1929)ATT>CTT	p.I643L	TTK_uc003pjb.3_Missense_Mutation_p.I642L	NM_003318	NP_003309	P33981	TTK_HUMAN	TTK protein kinase	643	Protein kinase.				mitotic cell cycle spindle assembly checkpoint|mitotic spindle organization|positive regulation of cell proliferation|positive regulation of pathway-restricted SMAD protein phosphorylation	spindle	ATP binding|identical protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(4)|stomach(2)|lung(2)|large_intestine(2)|pancreas(1)	11		all_cancers(76;0.00177)|Acute lymphoblastic leukemia(125;1.24e-05)|all_hematologic(105;0.00223)|all_epithelial(107;0.2)		BRCA - Breast invasive adenocarcinoma(397;0.0321)		TTTTAAAGGCATTGTTCACAG	0.328			NA											12	79					0	0	0.013537	0	0
C6orf191	253582	broad.mit.edu	37	6	130164711	130164711	+	Missense_Mutation	SNP	T	T	G			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr6:130164711T>G	uc003qbs.2	-	3	240	c.157A>C	c.(157-159)AAA>CAA	p.K53Q		NM_001010876	NP_001010876	Q5VVB8	CF191_HUMAN	hypothetical protein LOC253582	53						integral to membrane				large_intestine(1)	1				GBM - Glioblastoma multiforme(226;0.0387)|all cancers(137;0.115)|OV - Ovarian serous cystadenocarcinoma(155;0.131)		GGATTTGTTTTGAAATCAAAT	0.323			NA											4	119					0	0	0.014758	0	0
KDELR2	11014	broad.mit.edu	37	7	6505922	6505922	+	Silent	SNP	G	G	A			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr7:6505922G>A	uc003sqe.3	-	4	545	c.384C>T	c.(382-384)TCC>TCT	p.S128S	DAGLB_uc003sqd.3_Intron|KDELR2_uc003sqf.3_Intron	NM_006854	NP_006845	P33947	ERD22_HUMAN	KDEL receptor 2 isoform 1	128	Helical; (Potential).				intracellular protein transport|protein retention in ER lumen|vesicle-mediated transport	endoplasmic reticulum membrane|Golgi apparatus|integral to membrane	KDEL sequence binding|protein binding|receptor activity			ovary(1)|central_nervous_system(1)	2		Ovarian(82;0.0776)		UCEC - Uterine corpus endometrioid carcinoma (126;0.101)		GGATAGCCACGGACTCCAGGT	0.542			NA											9	58					0	0	0.008291	0	0
TWISTNB	221830	broad.mit.edu	37	7	19738091	19738091	+	Missense_Mutation	SNP	C	C	A			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr7:19738091C>A	uc003sup.1	-	4	886	c.865G>T	c.(865-867)GAC>TAC	p.D289Y		NM_001002926	NP_001002926	Q3B726	RPA43_HUMAN	TWIST neighbor	289	Lys-rich.					microtubule cytoskeleton|nucleolus	DNA-directed RNA polymerase activity			ovary(1)	1						GGGTCCTGGTCCTGAACTTCC	0.428			NA											30	346					1.99505e-19	2.67963e-19	0.012213	1	0
STK31	56164	broad.mit.edu	37	7	23793962	23793962	+	Nonsense_Mutation	SNP	A	A	T			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr7:23793962A>T	uc003sws.3	+	10	1229	c.1162A>T	c.(1162-1164)AAA>TAA	p.K388*	STK31_uc003swt.3_Nonsense_Mutation_p.K365*|STK31_uc011jze.1_Nonsense_Mutation_p.K388*|STK31_uc010kuq.2_Nonsense_Mutation_p.K365*	NM_031414	NP_113602	Q9BXU1	STK31_HUMAN	serine/threonine kinase 31 isoform a	388							ATP binding|nucleic acid binding|protein serine/threonine kinase activity			skin(3)|lung(2)|ovary(2)|stomach(2)	9						CCGTTTCGGAAAAGACCTTTC	0.368			NA											8	123					0	0	0.038147	0	0
STK31	56164	broad.mit.edu	37	7	23794038	23794038	+	Missense_Mutation	SNP	T	T	G			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr7:23794038T>G	uc003sws.3	+	10	1305	c.1238T>G	c.(1237-1239)ATA>AGA	p.I413R	STK31_uc003swt.3_Missense_Mutation_p.I390R|STK31_uc011jze.1_Missense_Mutation_p.I413R|STK31_uc010kuq.2_Missense_Mutation_p.I390R	NM_031414	NP_113602	Q9BXU1	STK31_HUMAN	serine/threonine kinase 31 isoform a	413							ATP binding|nucleic acid binding|protein serine/threonine kinase activity			skin(3)|lung(2)|ovary(2)|stomach(2)	9						GGATTAGAGATAATATGGGCA	0.388			NA											5	155					0	0	0.021553	0	0
CHCHD2	51142	broad.mit.edu	37	7	56172005	56172005	+	Missense_Mutation	SNP	C	C	T			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr7:56172005C>T	uc003tsa.2	-	2	295	c.214G>A	c.(214-216)GTG>ATG	p.V72M	PSPH_uc003trj.2_Intron	NM_016139	NP_057223	Q9Y6H1	CHCH2_HUMAN	coiled-coil-helix-coiled-coil-helix domain	72						mitochondrion					0	Breast(14;0.214)		Lung(13;0.00024)|LUSC - Lung squamous cell carcinoma(13;0.00099)			GTGTGCCCCACAGCAGAGCCC	0.612			NA											5	39					0	0	0.014758	0	0
TRIM50	135892	broad.mit.edu	37	7	72732960	72732960	+	Missense_Mutation	SNP	C	C	A			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr7:72732960C>A	uc010lbd.1	-	4	712	c.587G>T	c.(586-588)GGG>GTG	p.G196V	FKBP6_uc003twz.2_Intron|TRIM50_uc003txy.1_Missense_Mutation_p.G196V|TRIM50_uc003txz.1_Missense_Mutation_p.G196V	NM_178125	NP_835226	Q86XT4	TRI50_HUMAN	tripartite motif protein 50A	196						cytoplasm|intracellular membrane-bounded organelle	ligase activity|zinc ion binding			skin(1)	1						ACCCCCTATCCCCTCCAGGCA	0.667			NA											8	104					0.000274275	0.000300606	0.004482	1	0
ABCB4	5244	broad.mit.edu	37	7	87080995	87080995	+	Missense_Mutation	SNP	G	G	A			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr7:87080995G>A	uc003uiv.1	-	7	728	c.652C>T	c.(652-654)CTT>TTT	p.L218F	ABCB4_uc003uiw.1_Missense_Mutation_p.L218F|ABCB4_uc003uix.1_Missense_Mutation_p.L218F	NM_018849	NP_061337	P21439	MDR3_HUMAN	ATP-binding cassette, subfamily B, member 4	218	Helical; (By similarity).|ABC transmembrane type-1 1.				cellular lipid metabolic process	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus|membrane fraction	ATP binding|xenobiotic-transporting ATPase activity			ovary(4)|skin(1)|pancreas(1)	6	Esophageal squamous(14;0.0058)|all_lung(186;0.201)|Lung NSC(181;0.203)					ATTATCACAAGGGTGAGCTTC	0.468			NA											7	68					0	0	0.038147	0	0
MUC17	140453	broad.mit.edu	37	7	100679976	100679976	+	Missense_Mutation	SNP	C	C	A			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr7:100679976C>A	uc003uxp.1	+	3	5332	c.5279C>A	c.(5278-5280)CCG>CAG	p.P1760Q	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	1760	Extracellular (Potential).|59 X approximate tandem repeats.|27.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					AGCACCACGCCGGTACTCAGT	0.507			NA											22	316					9.04412e-07	1.0965e-06	0.024334	1	0
MUC17	140453	broad.mit.edu	37	7	100685846	100685846	+	Missense_Mutation	SNP	C	C	T			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr7:100685846C>T	uc003uxp.1	+	3	11202	c.11149C>T	c.(11149-11151)CCT>TCT	p.P3717S	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	3717	Extracellular (Potential).|59.|59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					CCTTTCAACACCTTCTGTTGT	0.507			NA											11	170					0	0	0.016723	0	0
GPR22	2845	broad.mit.edu	37	7	107115089	107115089	+	Missense_Mutation	SNP	T	T	A			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr7:107115089T>A	uc003vef.2	+	3	1930	c.584T>A	c.(583-585)CTT>CAT	p.L195H	COG5_uc003vec.2_Intron|COG5_uc003ved.2_Intron|COG5_uc003vee.2_Intron	NM_005295	NP_005286	Q99680	GPR22_HUMAN	G protein-coupled receptor 22	195	Extracellular (Potential).					integral to plasma membrane	G-protein coupled receptor activity			ovary(2)	2						AACAAGACACTTTTATGTGTC	0.313			NA											3	52					0	0	0.004672	0	0
C7orf58	79974	broad.mit.edu	37	7	120704319	120704319	+	Missense_Mutation	SNP	C	C	G			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr7:120704319C>G	uc003vjq.3	+	5	1015	c.568C>G	c.(568-570)CCA>GCA	p.P190A	C7orf58_uc003vjr.1_Missense_Mutation_p.P190A|C7orf58_uc003vjs.3_Missense_Mutation_p.P190A|C7orf58_uc003vjt.3_5'UTR	NM_024913	NP_079189	A4D0V7	CG058_HUMAN	hypothetical protein LOC79974 isoform 1	190						endoplasmic reticulum				ovary(4)|large_intestine(2)|skin(2)|pancreas(1)	9	all_neural(327;0.117)					AATACAGCAGCCACTTTGCAG	0.393			NA											6	61					0	0	0.02938	0	0
FAM40B	57464	broad.mit.edu	37	7	129125534	129125534	+	Missense_Mutation	SNP	T	T	C			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr7:129125534T>C	uc011koy.1	+	21	2409	c.2369T>C	c.(2368-2370)GTG>GCG	p.V790A	FAM40B_uc011koz.1_Missense_Mutation_p.V282A	NM_020704	NP_065755	Q9ULQ0	FA40B_HUMAN	hypothetical protein LOC57464 isoform a	790											0						TTTTCACCTGTGGATAACTGC	0.502			NA											14	66					0	0	0.020292	0	0
TAS2R60	338398	broad.mit.edu	37	7	143141101	143141101	+	Silent	SNP	C	C	A			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr7:143141101C>A	uc011ktg.1	+	1	556	c.556C>A	c.(556-558)CGG>AGG	p.R186R	uc003wda.2_Intron	NM_177437	NP_803186	P59551	T2R60_HUMAN	taste receptor, type 2, member 60	186	Helical; Name=5; (Potential).				sensory perception of bitter taste	integral to membrane	G-protein coupled receptor activity			skin(6)	6	Melanoma(164;0.172)					CGATAGCATACGGAGCTACTG	0.398			NA											23	145					3.08376e-08	3.94837e-08	0.01892	1	0
SYBU	55638	broad.mit.edu	37	8	110631185	110631185	+	Missense_Mutation	SNP	G	G	A			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr8:110631185G>A	uc003ynj.3	-	3	476	c.313C>T	c.(313-315)CCT>TCT	p.P105S	SYBU_uc003yni.3_Missense_Mutation_p.P102S|SYBU_uc003ynk.3_5'UTR|SYBU_uc010mco.2_Missense_Mutation_p.P104S|SYBU_uc003ynl.3_Missense_Mutation_p.P104S|SYBU_uc010mcp.2_Missense_Mutation_p.P105S|SYBU_uc010mcq.2_Missense_Mutation_p.P105S|SYBU_uc003yno.3_5'UTR|SYBU_uc010mcr.2_Missense_Mutation_p.P105S|SYBU_uc003ynm.3_Missense_Mutation_p.P104S|SYBU_uc003ynn.3_Missense_Mutation_p.P104S|SYBU_uc010mcs.2_5'UTR|SYBU_uc010mct.2_Missense_Mutation_p.P105S|SYBU_uc010mcu.2_Missense_Mutation_p.P104S|SYBU_uc003ynp.3_Missense_Mutation_p.P37S|SYBU_uc010mcv.2_Missense_Mutation_p.P105S	NM_001099754	NP_001093224	Q9NX95	SYBU_HUMAN	Golgi-localized syntaphilin-related protein	105	Sufficient for interaction with KIF5B.|Ser-rich.					cytoplasmic membrane-bounded vesicle|cytoskeleton|Golgi membrane|integral to membrane				ovary(1)	1						TCACTTCCAGGGCAAAAGCCA	0.483			NA											5	139					0	0	0.014758	0	0
GDA	9615	broad.mit.edu	37	9	74838084	74838084	+	Missense_Mutation	SNP	T	T	A			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr9:74838084T>A	uc004aiq.2	+	7	838	c.655T>A	c.(655-657)TCT>ACT	p.S219T	GDA_uc011lse.1_Missense_Mutation_p.S145T|GDA_uc011lsf.1_Missense_Mutation_p.S145T|GDA_uc004air.2_Missense_Mutation_p.S219T|GDA_uc010mow.1_RNA|GDA_uc004ais.2_Intron|GDA_uc004ait.1_Missense_Mutation_p.S145T	NM_004293	NP_004284	Q9Y2T3	GUAD_HUMAN	guanine deaminase	219					nervous system development|purine base metabolic process|purine nucleotide catabolic process	cytosol	guanine deaminase activity|zinc ion binding			ovary(2)|central_nervous_system(2)|skin(1)	5		Myeloproliferative disorder(762;0.0122)		Lung(182;0.0583)		CCTCTCCTGCTCTGAGACTTT	0.373			NA											12	71					0	0	0.020292	0	0
TMC1	117531	broad.mit.edu	37	9	75435847	75435847	+	Missense_Mutation	SNP	G	G	T			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr9:75435847G>T	uc004aiz.1	+	20	2393	c.1853G>T	c.(1852-1854)TGC>TTC	p.C618F	TMC1_uc010moz.1_Missense_Mutation_p.C576F|TMC1_uc004aja.1_RNA|TMC1_uc004ajb.1_RNA|TMC1_uc004ajc.1_Missense_Mutation_p.C472F|TMC1_uc010mpa.1_Missense_Mutation_p.C472F	NM_138691	NP_619636	Q8TDI8	TMC1_HUMAN	transmembrane channel-like 1	618	Cytoplasmic (Potential).				sensory perception of sound	integral to membrane				ovary(1)	1						GCCGTTATGTGCTGCAATGTT	0.502	Pancreas(75;173 1345 14232 34245 43413)		NA											10	133					0.000442599	0.00047745	0.006214	1	0
ROR2	4920	broad.mit.edu	37	9	94487168	94487168	+	Silent	SNP	G	G	A			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr9:94487168G>A	uc004arj.1	-	9	1807	c.1608C>T	c.(1606-1608)GTC>GTT	p.V536V	ROR2_uc004ari.1_Silent_p.V396V	NM_004560	NP_004551	Q01974	ROR2_HUMAN	receptor tyrosine kinase-like orphan receptor 2	536	Cytoplasmic (Potential).|Protein kinase.				negative regulation of cell proliferation|positive regulation of cell migration|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity|Wnt-protein binding			lung(8)|central_nervous_system(5)|ovary(3)|large_intestine(2)|stomach(1)|breast(1)	20						GCAGGCAGACGACGTTGGGGT	0.627			NA											11	63					0	0	0.008291	0	0
OR1N1	138883	broad.mit.edu	37	9	125289309	125289309	+	Silent	SNP	G	G	A			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr9:125289309G>A	uc004bmn.1	-	1	264	c.264C>T	c.(262-264)CAC>CAT	p.H88H		NM_012363	NP_036495	Q8NGS0	OR1N1_HUMAN	olfactory receptor, family 1, subfamily N,	88	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			upper_aerodigestive_tract(1)|breast(1)|skin(1)	3						AGGAGATGGTGTGATGCCGAG	0.473			NA											5	45					0	0	0.021553	0	0
NR6A1	2649	broad.mit.edu	37	9	127302372	127302372	+	Missense_Mutation	SNP	G	G	C			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr9:127302372G>C	uc004bor.1	-	5	714	c.536C>G	c.(535-537)TCC>TGC	p.S179C	NR6A1_uc004boq.1_Missense_Mutation_p.S175C|NR6A1_uc010mwq.1_Missense_Mutation_p.S175C	NM_033334	NP_201591	Q15406	NR6A1_HUMAN	nuclear receptor subfamily 6, group A, member 1	179	Sufficient for interaction with UIMC1 (By similarity).				cell proliferation|negative regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|spermatogenesis	transcription factor complex	protein homodimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			ovary(3)	3						GTTCCCAGGGGAACTGTGGTC	0.517	Esophageal Squamous(192;272 2884 6208 20560)		NA											18	93					0	0	0.0333	0	0
WDR38	401551	broad.mit.edu	37	9	127619095	127619095	+	Missense_Mutation	SNP	T	T	A			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr9:127619095T>A	uc004box.2	+	7	759	c.703T>A	c.(703-705)TGG>AGG	p.W235R	WDR38_uc011lzn.1_Missense_Mutation_p.W224R|WDR38_uc011lzo.1_Missense_Mutation_p.W235R|WDR38_uc011lzp.1_Missense_Mutation_p.W186R	NM_001045476	NP_001038941	Q5JTN6	WDR38_HUMAN	WD repeat domain 38	235	WD 6.										0						CCATGTCACCTGGGTGAAGAG	0.617			NA											14	52					0	0	0.016723	0	0
SHOX	6473	broad.mit.edu	37	X	591835	591835	+	Missense_Mutation	SNP	T	T	A			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chrX:591835T>A	uc004cph.1	+	2	894	c.203T>A	c.(202-204)GTG>GAG	p.V68E	SHOX_uc004cpi.2_Missense_Mutation_p.V68E	NM_000451	NP_000442	O15266	SHOX_HUMAN	short stature homeobox isoform SHOXa	68					skeletal system development|transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				CACTGCCCGGTGCATTTGTTC	0.602	Ovarian(95;18 1419 12424 14056 28266)		NA											9	88					0	0	0.006214	0	0
CXorf59	286464	broad.mit.edu	37	X	36103615	36103615	+	Missense_Mutation	SNP	C	C	A			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chrX:36103615C>A	uc004ddk.1	+	5	787	c.601C>A	c.(601-603)CAA>AAA	p.Q201K		NM_173695	NP_775966	Q8N9S7	CX059_HUMAN	hypothetical protein LOC286464	201						integral to membrane				central_nervous_system(1)	1						AAGGGTAATTCAACTCCATTT	0.378			NA											12	30					2.10051e-16	2.76701e-16	0.013537	1	0
F8	2157	broad.mit.edu	37	X	154128189	154128189	+	Silent	SNP	G	G	A			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chrX:154128189G>A	uc004fmt.2	-	21	6396	c.6225C>T	c.(6223-6225)TCC>TCT	p.S2075S	F8_uc010nvi.1_Intron	NM_000132	NP_000123	P00451	FA8_HUMAN	coagulation factor VIII isoform a precursor	2075	F5/8 type C 1.				acute-phase response|blood coagulation, intrinsic pathway|cell adhesion|platelet activation|platelet degranulation	extracellular space|plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity|protein binding			ovary(5)|large_intestine(2)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	11	all_cancers(53;7.19e-17)|all_epithelial(53;9.83e-11)|all_lung(58;6.63e-07)|Lung NSC(58;2.08e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)				Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Drotrecogin alfa(DB00055)	TGATTGATCCGGAATAATGAA	0.418			NA											4	26					0	0	0.009096	0	0
GAL3ST3	89792	broad.mit.edu	37	11	65810949	65810949	+	Frame_Shift_Del	DEL	G	G	-			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr11:65810949delG	uc001ogv.2	-	2	485	c.325delC	c.(325-327)CGCfs	p.R109fs	GAL3ST3_uc001ogw.2_Frame_Shift_Del_p.R109fs	NM_033036	NP_149025	Q96A11	G3ST3_HUMAN	galactose-3-O-sulfotransferase 3	109	Lumenal (Potential).				monosaccharide metabolic process|oligosaccharide metabolic process|poly-N-acetyllactosamine metabolic process|proteoglycan biosynthetic process|sulfur compound metabolic process	Golgi cisterna membrane|integral to membrane	3'-phosphoadenosine 5'-phosphosulfate binding|carbohydrate binding|galactosylceramide sulfotransferase activity|proteoglycan sulfotransferase activity			ovary(1)	1						GAGAAGTTGCGGGGGTAGCAG	0.692			NA											10	34	---	---	---	---	NA	NA	NA	NA	NA
TPTE	7179	broad.mit.edu	37	21	10944697	10944697	+	Frame_Shift_Del	DEL	A	A	-			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr21:10944697delA	uc002yip.1	-	11	905	c.537delT	c.(535-537)TTTfs	p.F179fs	TPTE_uc002yis.1_RNA|TPTE_uc002yiq.1_Frame_Shift_Del_p.F161fs|TPTE_uc002yir.1_Frame_Shift_Del_p.F141fs|TPTE_uc010gkv.1_Frame_Shift_Del_p.F41fs	NM_199261	NP_954870	P56180	TPTE_HUMAN	transmembrane phosphatase with tensin homology	179	Helical; (Potential).				signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(2)|lung(1)|breast(1)|skin(1)	5			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		ACTTAATGTCAAAAAAAATGT	0.299			NA											8	299	---	---	---	---	NA	NA	NA	NA	NA
ANKRD56	345079	broad.mit.edu	37	4	77816907	77816912	+	In_Frame_Del	DEL	ACATTT	ACATTT	-			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08	ACATTT	ACATTT	-	-	ACATTT	ACATTT	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr4:77816907_77816912delACATTT	uc003hki.2	-	1	2091_2096	c.2091_2096delAAATGT	c.(2089-2097)GTAAATGTC>GTC	p.697_699VNV>V		NM_001029870	NP_001025041	A6NEL2	ANR56_HUMAN	ankyrin repeat domain 56	697_699	ANK 2.										0						GCTGTCCCTGACATTTACCCGAGAAG	0.539			NA											27	334	---	---	---	---	NA	NA	NA	NA	NA
C6orf145	221749	broad.mit.edu	37	6	3751655	3751657	+	In_Frame_Del	DEL	CTC	CTC	-			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08	CTC	CTC	-	-	CTC	CTC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr6:3751655_3751657delCTC	uc003mvt.2	-	1	590_592	c.109_111delGAG	c.(109-111)GAGdel	p.E37del		NM_183373	NP_899229	Q5TGL8	CF145_HUMAN	hypothetical protein LOC221749	37	PX.				cell communication		phosphatidylinositol binding			breast(1)	1	Ovarian(93;0.0925)	all_hematologic(90;0.108)				TCTCGAAGAACTCCTCTTCGTCG	0.69			NA											2	4	---	---	---	---	NA	NA	NA	NA	NA
TRERF1	55809	broad.mit.edu	37	6	42196333	42196333	+	Frame_Shift_Del	DEL	T	T	-			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr6:42196333delT	uc003osd.2	-	18	3916	c.3353delA	c.(3352-3354)AAGfs	p.K1118fs	TRERF1_uc011duq.1_Frame_Shift_Del_p.K1035fs|TRERF1_uc003osb.2_Frame_Shift_Del_p.K886fs|TRERF1_uc003osc.2_Frame_Shift_Del_p.K874fs|TRERF1_uc003ose.2_Frame_Shift_Del_p.K1138fs	NM_033502	NP_277037	Q96PN7	TREF1_HUMAN	transcriptional regulating factor 1	1118	Interacts with CREBBP.				cholesterol catabolic process|homeostatic process|multicellular organismal development|positive regulation of transcription, DNA-dependent|regulation of hormone biosynthetic process|steroid biosynthetic process	nucleus	DNA bending activity|ligand-dependent nuclear receptor transcription coactivator activity|RNA polymerase II transcription cofactor activity|sequence-specific DNA binding transcription factor activity|transcription factor binding|zinc ion binding			ovary(3)|pancreas(1)|skin(1)	5	Colorectal(47;0.196)		Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)			CTTCTGAGCCTTTTGCCTCTG	0.542			NA											8	649	---	---	---	---	NA	NA	NA	NA	NA
CTSL2	1515	broad.mit.edu	37	9	99798905	99798905	+	Frame_Shift_Del	DEL	C	C	-			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr9:99798905delC	uc004awt.2	-	5	718	c.521delG	c.(520-522)GGCfs	p.G174fs	CTSL2_uc010msi.2_Frame_Shift_Del_p.G174fs|CTSL2_uc004awu.2_Frame_Shift_Del_p.G119fs|CTSL2_uc010msj.1_Frame_Shift_Del_p.G119fs|CTSL2_uc010msk.2_Frame_Shift_Del_p.G119fs	NM_001333	NP_001324	O60911	CATL2_HUMAN	cathepsin L2 preproprotein	174						lysosome	cysteine-type endopeptidase activity				0		Acute lymphoblastic leukemia(62;0.0559)				GCCCTGATTGCCTTGAGGACG	0.522			NA											9	70	---	---	---	---	NA	NA	NA	NA	NA