Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	ACHILLES_Top_Genes	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
KIAA1751	85452	broad.mit.edu	37	1	1919949	1919949	+	Splice_Site	SNP	A	A	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr1:1919949A>T	uc001aim.1	-	4	452	c.296_splice	c.e4+1	p.R99_splice	KIAA1751_uc009vkz.1_Splice_Site_p.R99_splice|KIAA1751_uc001ain.1_Splice_Site_p.R99_splice	NM_001080484	NP_001073953	Q9C0B2	K1751_HUMAN	hypothetical protein LOC85452											pancreas(1)	1	all_cancers(77;0.000708)|all_epithelial(69;0.000943)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;6.04e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Medulloblastoma(700;0.151)|Lung SC(97;0.217)		Epithelial(90;8.79e-39)|OV - Ovarian serous cystadenocarcinoma(86;9.61e-25)|GBM - Glioblastoma multiforme(42;1.2e-07)|Colorectal(212;4.84e-05)|COAD - Colon adenocarcinoma(227;0.000214)|Kidney(185;0.00254)|BRCA - Breast invasive adenocarcinoma(365;0.00461)|STAD - Stomach adenocarcinoma(132;0.00645)|KIRC - Kidney renal clear cell carcinoma(229;0.037)|Lung(427;0.205)		GCCCCAGCTCACCTCATCTTC	0.602			NA											24	61					0	0	0.00278	0	0
KIF1B	23095	broad.mit.edu	37	1	10342421	10342421	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr1:10342421G>C	uc001aqx.3	+	15	1466	c.1264G>C	c.(1264-1266)GCC>CCC	p.A422P	KIF1B_uc001aqv.3_Intron|KIF1B_uc001aqw.3_Intron|KIF1B_uc001aqy.2_Intron|KIF1B_uc001aqz.2_Missense_Mutation_p.A422P|KIF1B_uc001ara.2_Intron|KIF1B_uc001arb.2_Missense_Mutation_p.A408P	NM_015074	NP_055889	O60333	KIF1B_HUMAN	kinesin family member 1B isoform b	422					anterograde axon cargo transport|apoptosis|neuromuscular synaptic transmission|neuron-neuron synaptic transmission	cytoplasmic vesicle membrane|microtubule|microtubule associated complex|mitochondrion	ATP binding|ATPase activity|kinesin binding|microtubule motor activity|protein binding			ovary(2)|upper_aerodigestive_tract(1)	3	Ovarian(185;0.203)	all_lung(284;1.31e-05)|Lung NSC(185;2.2e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0259)|Colorectal(212;9.79e-07)|COAD - Colon adenocarcinoma(227;0.000143)|BRCA - Breast invasive adenocarcinoma(304;0.000413)|Kidney(185;0.00134)|KIRC - Kidney renal clear cell carcinoma(229;0.0037)|STAD - Stomach adenocarcinoma(132;0.0113)|READ - Rectum adenocarcinoma(331;0.0642)		ATACTTGCTAGCCTCTGAGAA	0.358			NA											8	120					0	0	0.00308	0	0
PRDM2	7799	broad.mit.edu	37	1	14107413	14107413	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr1:14107413G>A	uc001avi.2	+	8	3979	c.3123G>A	c.(3121-3123)ATG>ATA	p.M1041I	PRDM2_uc001avg.2_Intron|PRDM2_uc001avh.2_Missense_Mutation_p.M1041I|PRDM2_uc001avj.2_Intron|PRDM2_uc001avk.2_Missense_Mutation_p.M840I|PRDM2_uc009voe.2_Intron|PRDM2_uc009vof.2_Intron	NM_012231	NP_036363	Q13029	PRDM2_HUMAN	retinoblastoma protein-binding zinc finger	1041	SH3-binding (Potential).|Pro-rich.					Golgi apparatus|nucleus	DNA binding|histone-lysine N-methyltransferase activity|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1	Ovarian(185;0.249)	all_lung(284;2.56e-05)|Lung NSC(185;4.94e-05)|Renal(390;0.000147)|Breast(348;0.000162)|Colorectal(325;0.00058)|Ovarian(437;0.00965)|Hepatocellular(190;0.0245)|Myeloproliferative disorder(586;0.0255)	GBM - Glioblastoma multiforme(2;0.00182)	UCEC - Uterine corpus endometrioid carcinoma (279;0.00224)|Colorectal(212;3.23e-08)|BRCA - Breast invasive adenocarcinoma(304;2.16e-05)|COAD - Colon adenocarcinoma(227;2.53e-05)|Kidney(185;0.000762)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(313;0.00446)|READ - Rectum adenocarcinoma(331;0.0276)|Lung(427;0.145)		AGCCCCTGATGTCTGCCGCCT	0.408			NA											11	48					0	0	0.00245	0	0
DNAJC16	23341	broad.mit.edu	37	1	15888820	15888820	+	Silent	SNP	G	G	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr1:15888820G>A	uc001aws.2	+	9	1458	c.1338G>A	c.(1336-1338)GCG>GCA	p.A446A	DNAJC16_uc001awr.1_Silent_p.A446A|DNAJC16_uc001awt.2_Silent_p.A134A|DNAJC16_uc001awu.2_RNA	NM_015291	NP_056106	Q9Y2G8	DJC16_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 16	446	Cytoplasmic (Potential).				cell redox homeostasis|protein folding	integral to membrane	heat shock protein binding|unfolded protein binding			urinary_tract(1)|lung(1)|kidney(1)	3		Colorectal(325;0.00108)|Renal(390;0.00145)|Breast(348;0.00173)|all_lung(284;0.00459)|Lung NSC(340;0.00499)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0798)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;9.18e-07)|COAD - Colon adenocarcinoma(227;4.5e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000133)|KIRC - Kidney renal clear cell carcinoma(229;0.00262)|STAD - Stomach adenocarcinoma(313;0.00774)|READ - Rectum adenocarcinoma(331;0.0657)		GGAAATCAGCGGTAAGCCACA	0.478			NA											32	82					0	0	0.002096	0	0
CROCC	9696	broad.mit.edu	37	1	17279852	17279852	+	Missense_Mutation	SNP	A	A	G			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr1:17279852A>G	uc001azt.2	+	21	3131	c.3062A>G	c.(3061-3063)CAG>CGG	p.Q1021R	CROCC_uc009voz.1_Missense_Mutation_p.Q620R|CROCC_uc001azu.2_Missense_Mutation_p.Q324R	NM_014675	NP_055490	Q5TZA2	CROCC_HUMAN	ciliary rootlet coiled-coil	1021	Potential.				cell cycle|cell projection organization|centrosome organization|protein localization	actin cytoskeleton|centriole|ciliary rootlet|plasma membrane	kinesin binding|structural molecule activity			ovary(2)|breast(2)|central_nervous_system(1)	5		Colorectal(325;3.46e-05)|Breast(348;0.000162)|Lung NSC(340;0.000174)|all_lung(284;0.000234)|Renal(390;0.000518)|Ovarian(437;0.00669)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.63e-06)|COAD - Colon adenocarcinoma(227;1.07e-05)|Kidney(64;0.000163)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.181)		AGTCAGCTGCAGCGTGAGCAG	0.692			NA											4	5					0	0	0.000978	0	0
PADI6	353238	broad.mit.edu	37	1	17714922	17714922	+	Missense_Mutation	SNP	C	C	G	rs113151411		TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr1:17714922C>G	uc001bak.1	+	7	726	c.726C>G	c.(724-726)CAC>CAG	p.H242Q		NM_207421	NP_997304	Q6TGC4	PADI6_HUMAN	peptidylarginine deiminase type 6	234					peptidyl-citrulline biosynthetic process from peptidyl-arginine	cytoplasm|nucleus	calcium ion binding|protein-arginine deiminase activity			breast(1)	1		Colorectal(325;3.46e-05)|Breast(348;0.000162)|all_lung(284;0.000337)|Lung NSC(340;0.000419)|Renal(390;0.000518)|Ovarian(437;0.00409)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00488)|BRCA - Breast invasive adenocarcinoma(304;7.59e-06)|COAD - Colon adenocarcinoma(227;1.18e-05)|Kidney(64;0.000186)|KIRC - Kidney renal clear cell carcinoma(64;0.00272)|STAD - Stomach adenocarcinoma(196;0.0134)|READ - Rectum adenocarcinoma(331;0.0655)|Lung(427;0.189)	L-Citrulline(DB00155)	CCGACCAGCACGCCTATACCT	0.537			NA											4	30					0	0	0.000602	0	0
PLA2G2F	64600	broad.mit.edu	37	1	20474888	20474888	+	Silent	SNP	T	T	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr1:20474888T>A	uc009vpp.1	+	5	728	c.630T>A	c.(628-630)CCT>CCA	p.P210P		NM_022819	NP_073730	Q9BZM2	PA2GF_HUMAN	phospholipase A2, group IIF	167					lipid catabolic process|phospholipid metabolic process	extracellular region	calcium ion binding|phospholipase A2 activity			ovary(1)	1		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000247)|Lung NSC(340;0.000285)|Breast(348;0.000812)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.018)|COAD - Colon adenocarcinoma(152;1.13e-05)|BRCA - Breast invasive adenocarcinoma(304;8.01e-05)|Kidney(64;0.00017)|GBM - Glioblastoma multiforme(114;0.000524)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.198)		CCCCCGCCCCTCCCTAGAGCC	0.652			NA											8	36					0	0	0.006214	0	0
KIF17	57576	broad.mit.edu	37	1	21009182	21009182	+	Silent	SNP	C	C	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr1:21009182C>A	uc001bdr.3	-	11	2545	c.2427G>T	c.(2425-2427)CGG>CGT	p.R809R	KIF17_uc001bdp.3_Silent_p.R87R|KIF17_uc001bdq.3_Silent_p.R87R|KIF17_uc009vpx.2_Silent_p.R179R|KIF17_uc001bds.3_Silent_p.R809R	NM_020816	NP_065867	Q9P2E2	KIF17_HUMAN	kinesin family member 17 isoform a	809	Potential.				microtubule-based movement|protein transport	cytoplasm|microtubule	ATP binding			ovary(3)|skin(1)	4		all_lung(284;2.99e-05)|Lung NSC(340;3.26e-05)|Colorectal(325;3.46e-05)|Renal(390;9.67e-05)|Breast(348;0.00179)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0185)|COAD - Colon adenocarcinoma(152;1.43e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000168)|Kidney(64;0.000221)|GBM - Glioblastoma multiforme(114;0.000651)|KIRC - Kidney renal clear cell carcinoma(64;0.0031)|STAD - Stomach adenocarcinoma(196;0.00336)|READ - Rectum adenocarcinoma(331;0.0686)|Lung(427;0.209)		TGCTCTTGGCCCGCACTTCCT	0.632			NA											33	60					1.414e-09	1.88005e-09	0.003755	1	0
HP1BP3	50809	broad.mit.edu	37	1	21071530	21071530	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr1:21071530C>A	uc001bdw.1	-	13	1562	c.1422G>T	c.(1420-1422)CAG>CAT	p.Q474H	HP1BP3_uc001bdv.1_Missense_Mutation_p.Q436H|HP1BP3_uc010odh.1_Missense_Mutation_p.Q436H|HP1BP3_uc001bdy.1_Missense_Mutation_p.Q474H|HP1BP3_uc010odf.1_Missense_Mutation_p.Q133H|HP1BP3_uc010odg.1_Missense_Mutation_p.Q322H	NM_016287	NP_057371	Q5SSJ5	HP1B3_HUMAN	HP1-BP74	474	Lys-rich.				nucleosome assembly	nucleosome|nucleus	DNA binding			central_nervous_system(1)|skin(1)	2		all_lung(284;6.55e-06)|Lung NSC(340;6.59e-06)|Colorectal(325;3.46e-05)|Renal(390;9.67e-05)|Breast(348;0.00179)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0182)|COAD - Colon adenocarcinoma(152;1.26e-05)|BRCA - Breast invasive adenocarcinoma(304;0.00015)|GBM - Glioblastoma multiforme(114;0.000521)|Kidney(64;0.000529)|STAD - Stomach adenocarcinoma(196;0.00311)|KIRC - Kidney renal clear cell carcinoma(64;0.00687)|READ - Rectum adenocarcinoma(331;0.0655)|Lung(427;0.201)		TGGACCCTCTCTGCTTCACAG	0.537			NA											28	169					3.99451e-17	6.01078e-17	0.009535	1	0
EPHA8	2046	broad.mit.edu	37	1	22915542	22915542	+	Silent	SNP	G	G	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr1:22915542G>T	uc001bfx.1	+	5	1283	c.1158G>T	c.(1156-1158)GTG>GTT	p.V386V	EPHA8_uc001bfw.2_Silent_p.V386V	NM_020526	NP_065387	P29322	EPHA8_HUMAN	ephrin receptor EphA8 isoform 1 precursor	386	Extracellular (Potential).|Fibronectin type-III 1.					integral to plasma membrane	ATP binding|ephrin receptor activity			central_nervous_system(5)|breast(3)|lung(2)|large_intestine(1)|stomach(1)|skin(1)	13		Colorectal(325;3.46e-05)|Lung NSC(340;6.55e-05)|all_lung(284;9.87e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;7.29e-27)|Colorectal(126;1.61e-07)|COAD - Colon adenocarcinoma(152;1.14e-05)|GBM - Glioblastoma multiforme(114;1.74e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000554)|KIRC - Kidney renal clear cell carcinoma(1967;0.00272)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.199)		CCCGCTTTGTGCCCCAGCAGA	0.662			NA											6	20					8.12818e-05	9.27259e-05	0.001984	1	0
SLC30A2	7780	broad.mit.edu	37	1	26371545	26371545	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr1:26371545G>A	uc001blh.1	-	2	431	c.214C>T	c.(214-216)CGC>TGC	p.R72C	SLC30A2_uc001blg.1_Missense_Mutation_p.R72C	NM_032513	NP_115902	Q9BRI3	ZNT2_HUMAN	solute carrier family 30, member 2 isoform 2	72	Cytoplasmic (Potential).				positive regulation of sequestering of zinc ion|zinc ion transport	integral to membrane|late endosome|lysosomal membrane	cation transmembrane transporter activity				0		Colorectal(325;3.46e-05)|Lung NSC(340;6.18e-05)|all_lung(284;9.43e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0155)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0298)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;7.09e-26)|Colorectal(126;2.96e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.000728)|BRCA - Breast invasive adenocarcinoma(304;0.000969)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.00614)|READ - Rectum adenocarcinoma(331;0.0649)		TACAGCTGGCGCTGGGCCTTC	0.532			NA											8	231					0	0	0.004482	0	0
CNKSR1	10256	broad.mit.edu	37	1	26509068	26509068	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr1:26509068G>T	uc001bln.3	+	6	675	c.617G>T	c.(616-618)AGT>ATT	p.S206I	CNKSR1_uc010oex.1_RNA|CNKSR1_uc001blm.3_Missense_Mutation_p.S206I|CNKSR1_uc009vsd.2_5'UTR|CNKSR1_uc009vse.2_5'UTR|CNKSR1_uc001blo.2_5'UTR	NM_006314	NP_006305	Q969H4	CNKR1_HUMAN	connector enhancer of kinase suppressor of Ras	206	PDZ.				Rho protein signal transduction|transmembrane receptor protein tyrosine kinase signaling pathway	cell cortex|cell-cell junction	protein binding, bridging			lung(1)|kidney(1)	2		Colorectal(325;3.46e-05)|all_lung(284;0.000116)|Lung NSC(340;0.000154)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0133)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0298)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;2.72e-26)|Colorectal(126;1.24e-08)|COAD - Colon adenocarcinoma(152;9.31e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00072)|BRCA - Breast invasive adenocarcinoma(304;0.000959)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.00823)|READ - Rectum adenocarcinoma(331;0.0649)		CAGCTGGACAGTCCATTGGTG	0.617	NSCLC(180;1396 2109 28270 30756 34275)		NA											13	25					6.31663e-08	7.95241e-08	0.003163	1	0
GJB4	127534	broad.mit.edu	37	1	35227242	35227242	+	Nonsense_Mutation	SNP	G	G	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr1:35227242G>A	uc001bxv.1	+	2	757	c.387G>A	c.(385-387)TGG>TGA	p.W129*	GJB4_uc001bxw.3_Nonsense_Mutation_p.W129*	NM_153212	NP_694944	Q9NTQ9	CXB4_HUMAN	gap junction protein, beta 4	129	Helical; (Potential).				cell communication	connexon complex|integral to membrane	gap junction channel activity			ovary(2)|central_nervous_system(1)	3		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.234)				GACTGTGGTGGACGTACTTGC	0.607			NA											20	48					0	0	0.010504	0	0
HIVEP3	59269	broad.mit.edu	37	1	41978593	41978593	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr1:41978593C>A	uc001cgz.3	-	8	7512	c.6299G>T	c.(6298-6300)GGG>GTG	p.G2100V	HIVEP3_uc001cha.3_Missense_Mutation_p.G2100V|HIVEP3_uc001cgy.2_RNA	NM_024503	NP_078779	Q5T1R4	ZEP3_HUMAN	human immunodeficiency virus type I enhancer	2100	6 X 4 AA tandem repeats of S-P-X-[RK].				positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			ovary(4)|large_intestine(1)|central_nervous_system(1)	6	Ovarian(52;0.00769)|all_hematologic(146;0.109)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0367)				GCCATGCTCCCCCGCTGAGGG	0.701			NA											5	11					0.00198382	0.00213469	0.001984	1	0
ST3GAL3	6487	broad.mit.edu	37	1	44386499	44386499	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr1:44386499G>T	uc001ckc.2	+	11	1114	c.937G>T	c.(937-939)GGC>TGC	p.G313C	ST3GAL3_uc001cjz.2_Missense_Mutation_p.G328C|ST3GAL3_uc001cka.2_Intron|ST3GAL3_uc001ckb.2_Missense_Mutation_p.G382C|ST3GAL3_uc001ckd.2_Missense_Mutation_p.G367C|ST3GAL3_uc001cke.2_Missense_Mutation_p.G297C|ST3GAL3_uc001ckf.2_Missense_Mutation_p.G351C|ST3GAL3_uc001ckg.2_Intron|ST3GAL3_uc001ckh.2_Intron|ST3GAL3_uc001cki.2_Intron|ST3GAL3_uc009vwv.2_Missense_Mutation_p.G283C|ST3GAL3_uc001ckj.2_RNA|ST3GAL3_uc009vww.2_RNA|ST3GAL3_uc001ckk.2_Missense_Mutation_p.G282C|ST3GAL3_uc009vwy.2_Missense_Mutation_p.G219C|ST3GAL3_uc009vwx.2_Intron|ST3GAL3_uc001ckm.2_Intron|ST3GAL3_uc001ckl.2_Intron|ST3GAL3_uc009vwz.2_Missense_Mutation_p.G87C|ST3GAL3_uc001ckn.2_Intron|ST3GAL3_uc001ckp.2_Intron|ST3GAL3_uc001cko.2_Intron|ST3GAL3_uc009vxa.2_Missense_Mutation_p.G100C|ST3GAL3_uc001ckq.2_Intron|ST3GAL3_uc001ckr.2_Intron|ST3GAL3_uc009vxb.2_Intron	NM_006279	NP_006270	Q11203	SIAT6_HUMAN	sialyltransferase 6 isoform j	313	Lumenal (Potential).				protein glycosylation	extracellular region|Golgi cisterna membrane|integral to Golgi membrane	N-acetyllactosaminide alpha-2,3-sialyltransferase activity			ovary(3)	3	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0518)				GGCACTACACGGCTGTGACGA	0.577			NA											4	73					3.59834e-05	4.13983e-05	0.001168	1	0
CYP4B1	1580	broad.mit.edu	37	1	47279694	47279694	+	Missense_Mutation	SNP	G	G	T	rs139993247	byFrequency	TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr1:47279694G>T	uc001cqm.3	+	6	815	c.731G>T	c.(730-732)CGC>CTC	p.R244L	CYP4B1_uc009vyl.1_Missense_Mutation_p.R81L|CYP4B1_uc001cqn.3_Missense_Mutation_p.R245L|CYP4B1_uc009vym.2_Missense_Mutation_p.R230L|CYP4B1_uc010omk.1_Missense_Mutation_p.R81L|CYP4B1_uc010oml.1_Missense_Mutation_p.R82L	NM_000779	NP_000770	P13584	CP4B1_HUMAN	cytochrome P450, family 4, subfamily B,	244					xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding			ovary(1)|skin(1)	2	Acute lymphoblastic leukemia(166;0.155)					CCACATGGCCGCCGCTTCCTG	0.592			NA											49	102					1.38909e-20	2.15526e-20	0.00361	1	0
FOXD2	2306	broad.mit.edu	37	1	47904171	47904171	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr1:47904171C>T	uc001crm.2	+	1	2483	c.364C>T	c.(364-366)CGG>TGG	p.R122W		NM_004474	NP_004465	O60548	FOXD2_HUMAN	forkhead box D2	122					axon extension involved in axon guidance|cartilage development|dichotomous subdivision of terminal units involved in ureteric bud branching|embryo development|enteric nervous system development|iridophore differentiation|lateral line nerve glial cell development|melanocyte differentiation|neural crest cell migration|pattern specification process|peripheral nervous system development|positive regulation of BMP signaling pathway|positive regulation of kidney development|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity|sympathetic nervous system development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding				0				READ - Rectum adenocarcinoma(2;0.0908)		cgcggcgACGCGGAGCCCGCT	0.328			NA											4	19					0	0	0.000602	0	0
C1orf141	400757	broad.mit.edu	37	1	67591503	67591503	+	Silent	SNP	A	A	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr1:67591503A>T	uc001ddl.1	-	3	276	c.165T>A	c.(163-165)GCT>GCA	p.A55A	C1orf141_uc001ddm.1_Silent_p.A55A|C1orf141_uc001ddn.1_RNA	NM_001013674	NP_001013696	Q5JVX7	CA141_HUMAN	hypothetical protein LOC400757	55										ovary(1)	1						ACGCGGATGTAGCAAGAGCTT	0.363			NA											29	185					0	0	0.002096	0	0
LRRIQ3	127255	broad.mit.edu	37	1	74648512	74648512	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr1:74648512C>G	uc001dfy.3	-	3	475	c.283G>C	c.(283-285)GGA>CGA	p.G95R	LRRIQ3_uc001dfz.3_RNA	NM_001105659	NP_001099129	A6PVS8	LRIQ3_HUMAN	leucine-rich repeats and IQ motif containing 3	95										ovary(2)	2						TTCTTCAATCCATTCCAAAAT	0.308			NA											6	28					0	0	0.001168	0	0
C1orf173	127254	broad.mit.edu	37	1	75037858	75037858	+	Missense_Mutation	SNP	C	C	A	rs76571187		TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr1:75037858C>A	uc001dgg.2	-	14	3755	c.3536G>T	c.(3535-3537)GGG>GTG	p.G1179V		NM_001002912	NP_001002912	Q5RHP9	CA173_HUMAN	hypothetical protein LOC127254	1179	Glu-rich.									ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	5						CAGTCTTTCCCCTCCTCCTTC	0.493			NA											36	241					1.47244e-24	2.36991e-24	0.00623	1	0
C1orf173	127254	broad.mit.edu	37	1	75107077	75107077	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr1:75107077G>T	uc001dgg.2	-	5	601	c.382C>A	c.(382-384)CCA>ACA	p.P128T		NM_001002912	NP_001002912	Q5RHP9	CA173_HUMAN	hypothetical protein LOC127254	128										ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	5						TTACTCTTTGGGCCAACTGGT	0.443			NA											19	95					4.35082e-09	5.68907e-09	0.010504	1	0
LHX8	431707	broad.mit.edu	37	1	75608902	75608902	+	Silent	SNP	C	C	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr1:75608902C>A	uc001dgo.2	+	6	1153	c.489C>A	c.(487-489)GCC>GCA	p.A163A	LHX8_uc001dgq.2_Silent_p.A102A	NM_001001933	NP_001001933	Q68G74	LHX8_HUMAN	LIM homeobox 8	163	LIM zinc-binding 2.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(3)	3						CATGCTTTGCCTGCTTTTCCT	0.488			NA											21	83					4.26978e-12	6.00556e-12	0.00333	1	0
SLC44A5	204962	broad.mit.edu	37	1	75681537	75681537	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr1:75681537G>C	uc001dgu.2	-	19	1774	c.1630C>G	c.(1630-1632)CAG>GAG	p.Q544E	SLC44A5_uc001dgt.2_Missense_Mutation_p.Q544E|SLC44A5_uc001dgs.2_Missense_Mutation_p.Q502E|SLC44A5_uc001dgr.2_Missense_Mutation_p.Q502E|SLC44A5_uc010oqz.1_Missense_Mutation_p.Q583E|SLC44A5_uc010ora.1_Missense_Mutation_p.Q538E|SLC44A5_uc010orb.1_Missense_Mutation_p.Q414E	NM_152697	NP_689910	Q8NCS7	CTL5_HUMAN	solute carrier family 44, member 5 isoform A	544	Cytoplasmic (Potential).					integral to membrane|plasma membrane	choline transmembrane transporter activity			ovary(2)|skin(2)	4						AATGTGTTCTGGGTACCTATG	0.303			NA											8	49					0	0	0.008291	0	0
SLC44A5	204962	broad.mit.edu	37	1	75693506	75693506	+	Missense_Mutation	SNP	T	T	G			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr1:75693506T>G	uc001dgu.2	-	13	1034	c.890A>C	c.(889-891)CAG>CCG	p.Q297P	SLC44A5_uc001dgt.2_Missense_Mutation_p.Q297P|SLC44A5_uc001dgs.2_Missense_Mutation_p.Q255P|SLC44A5_uc001dgr.2_Missense_Mutation_p.Q255P|SLC44A5_uc010oqz.1_Missense_Mutation_p.Q336P|SLC44A5_uc010ora.1_Missense_Mutation_p.Q291P|SLC44A5_uc010orb.1_Missense_Mutation_p.Q167P	NM_152697	NP_689910	Q8NCS7	CTL5_HUMAN	solute carrier family 44, member 5 isoform A	297	Extracellular (Potential).					integral to membrane|plasma membrane	choline transmembrane transporter activity			ovary(2)|skin(2)	4						TGGGCGTTCCTGAAGATTGGT	0.348			NA											6	53					0	0	0.001168	0	0
MSH4	4438	broad.mit.edu	37	1	76355032	76355032	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr1:76355032C>T	uc001dhd.1	+	16	2245	c.2204C>T	c.(2203-2205)ACA>ATA	p.T735I		NM_002440	NP_002431	O15457	MSH4_HUMAN	mutS homolog 4	735					chiasma assembly|homologous chromosome segregation|mismatch repair|reciprocal meiotic recombination	synaptonemal complex	ATP binding|DNA-dependent ATPase activity|mismatched DNA binding			lung(3)|ovary(2)	5						AATTCATCAACATTTATGAAA	0.279			NA						MMR					11	59					0	0	0.001368	0	0
ZZZ3	26009	broad.mit.edu	37	1	78098720	78098720	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr1:78098720C>T	uc001dhq.2	-	5	796	c.320G>A	c.(319-321)AGG>AAG	p.R107K	ZZZ3_uc001dhr.2_Intron|ZZZ3_uc009wbz.1_Missense_Mutation_p.R107K|ZZZ3_uc001dhp.2_Missense_Mutation_p.R107K	NM_015534	NP_056349	Q8IYH5	ZZZ3_HUMAN	zinc finger, ZZ-type containing 3	107					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(4)|large_intestine(1)	5						TTCTGTTTGCCTTCTCTCACA	0.388			NA											39	266					0	0	0.004289	0	0
ZNF326	284695	broad.mit.edu	37	1	90484244	90484244	+	Nonsense_Mutation	SNP	G	G	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr1:90484244G>T	uc001dnq.2	+	9	1214	c.1075G>T	c.(1075-1077)GAG>TAG	p.E359*	ZNF326_uc009wda.1_Nonsense_Mutation_p.E270*|ZNF326_uc001dnr.2_Nonsense_Mutation_p.E153*	NM_182976	NP_892021	Q5BKZ1	ZN326_HUMAN	zinc finger protein 326 isoform 1	359					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear matrix	DNA binding			ovary(1)	1		all_lung(203;0.0116)|Lung NSC(277;0.0417)		all cancers(265;0.00728)|Epithelial(280;0.0265)		TGTTTTCTAGGAGTGTATGGT	0.303			NA											5	30					0.000602214	0.000665384	0.000602	1	0
HFM1	164045	broad.mit.edu	37	1	91740287	91740287	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr1:91740287C>G	uc001doa.3	-	33	3768	c.3668G>C	c.(3667-3669)AGG>ACG	p.R1223T	HFM1_uc009wdb.2_RNA|HFM1_uc010osu.1_Missense_Mutation_p.R902T|HFM1_uc001dob.3_Missense_Mutation_p.R411T|HFM1_uc010osv.1_Missense_Mutation_p.R907T	NM_001017975	NP_001017975	A2PYH4	HFM1_HUMAN	HFM1 protein	1223							ATP binding|ATP-dependent helicase activity|nucleic acid binding				0		all_lung(203;0.00961)|Lung NSC(277;0.0351)		all cancers(265;0.000481)|Epithelial(280;0.00863)|OV - Ovarian serous cystadenocarcinoma(397;0.126)|KIRC - Kidney renal clear cell carcinoma(1967;0.171)		ATATTTGTACCTTGATATACT	0.323			NA											4	22					0	0	0.000602	0	0
HFM1	164045	broad.mit.edu	37	1	91742226	91742226	+	Missense_Mutation	SNP	T	T	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr1:91742226T>A	uc001doa.3	-	32	3647	c.3547A>T	c.(3547-3549)AGG>TGG	p.R1183W	HFM1_uc009wdb.2_RNA|HFM1_uc010osu.1_Missense_Mutation_p.R862W|HFM1_uc001dob.3_Missense_Mutation_p.R371W|HFM1_uc010osv.1_Missense_Mutation_p.R867W	NM_001017975	NP_001017975	A2PYH4	HFM1_HUMAN	HFM1 protein	1183							ATP binding|ATP-dependent helicase activity|nucleic acid binding				0		all_lung(203;0.00961)|Lung NSC(277;0.0351)		all cancers(265;0.000481)|Epithelial(280;0.00863)|OV - Ovarian serous cystadenocarcinoma(397;0.126)|KIRC - Kidney renal clear cell carcinoma(1967;0.171)		ACAGCATTCCTGTTTCTTAAA	0.294			NA											5	24					0	0	0.001984	0	0
BRDT	676	broad.mit.edu	37	1	92441976	92441976	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr1:92441976G>T	uc001dok.3	+	5	948	c.599G>T	c.(598-600)AGT>ATT	p.S200I	BRDT_uc001dol.3_Missense_Mutation_p.S200I|BRDT_uc010osz.1_Missense_Mutation_p.S204I|BRDT_uc009wdf.2_Missense_Mutation_p.S127I|BRDT_uc010ota.1_Missense_Mutation_p.S154I|BRDT_uc010otb.1_Missense_Mutation_p.S154I|BRDT_uc001dom.3_Missense_Mutation_p.S200I	NM_207189	NP_997072	Q58F21	BRDT_HUMAN	testis-specific bromodomain protein	200					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein serine/threonine kinase activity|transcription coactivator activity			stomach(2)|ovary(1)|lung(1)	4		all_lung(203;0.00531)|Lung NSC(277;0.0194)		all cancers(265;0.0228)|Epithelial(280;0.133)		GTCAACTCCAGTTCACAAACT	0.358			NA											14	64					2.31682e-05	2.68831e-05	0.003163	1	0
AMY1A	276	broad.mit.edu	37	1	104297220	104297220	+	Silent	SNP	T	T	C			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr1:104297220T>C	uc001duy.2	+	7	1192	c.978T>C	c.(976-978)TCT>TCC	p.S326S	AMY1A_uc001duz.2_Silent_p.S326S	NM_001008221	NP_001008222	P04745	AMY1_HUMAN	salivary amylase alpha 1A precursor	326					carbohydrate metabolic process|digestion	extracellular region	alpha-amylase activity|metal ion binding|protein binding				0		all_epithelial(167;3.05e-05)|all_lung(203;0.000199)|Lung NSC(277;0.000451)		Colorectal(144;0.0654)|all cancers(265;0.0808)|Epithelial(280;0.0921)|Lung(183;0.111)		GAGGAGCCTCTATACTTACCT	0.413	Pancreas(131;743 2392 43382 44986)		NA											19	429					0	0	0.00623	0	0
VAV3	10451	broad.mit.edu	37	1	108303496	108303496	+	Nonsense_Mutation	SNP	A	A	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr1:108303496A>T	uc001dvk.1	-	10	981	c.927T>A	c.(925-927)TGT>TGA	p.C309*	VAV3_uc010ouw.1_Nonsense_Mutation_p.C309*|VAV3_uc001dvl.1_Nonsense_Mutation_p.C133*|VAV3_uc010oux.1_Nonsense_Mutation_p.C309*	NM_006113	NP_006104	Q9UKW4	VAV3_HUMAN	vav 3 guanine nucleotide exchange factor isoform	309	DH.				angiogenesis|apoptosis|B cell receptor signaling pathway|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of B cell proliferation|regulation of Rho protein signal transduction|response to DNA damage stimulus|response to drug|small GTPase mediated signal transduction	cytosol	GTPase activator activity|metal ion binding|SH3/SH2 adaptor activity			ovary(5)|lung(2)|breast(2)	9		all_epithelial(167;5.38e-05)|all_lung(203;0.000314)|Lung NSC(277;0.000594)		Colorectal(144;0.0331)|Lung(183;0.128)|Epithelial(280;0.204)		CTCTTTTGGAACATTCCTAAT	0.353			NA											3	22					0	0	0.004672	0	0
KIAA1324	57535	broad.mit.edu	37	1	109735309	109735309	+	Missense_Mutation	SNP	A	A	G			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr1:109735309A>G	uc001dwq.2	+	15	1896	c.1760A>G	c.(1759-1761)TAC>TGC	p.Y587C	KIAA1324_uc009wex.1_Missense_Mutation_p.Y537C|KIAA1324_uc009wey.2_Missense_Mutation_p.Y500C|KIAA1324_uc010ovg.1_Missense_Mutation_p.Y485C|KIAA1324_uc001dwr.2_Missense_Mutation_p.Y237C	NM_020775	NP_065826	Q6UXG2	K1324_HUMAN	hypothetical protein LOC57535 precursor	587	Extracellular (Potential).				macroautophagy|positive regulation of vacuole organization|regulation of apoptosis	integral to plasma membrane				ovary(2)|haematopoietic_and_lymphoid_tissue(1)|breast(1)|skin(1)	5		all_epithelial(167;0.000102)|all_lung(203;0.000323)|Lung NSC(277;0.00063)		Colorectal(144;0.0188)|Lung(183;0.0527)|COAD - Colon adenocarcinoma(174;0.14)|Epithelial(280;0.21)|all cancers(265;0.249)		GTGGCCTCCTACTGCCGTCCC	0.522			NA											51	318					0	0	0.00361	0	0
KIAA1324	57535	broad.mit.edu	37	1	109740147	109740147	+	Nonsense_Mutation	SNP	G	G	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr1:109740147G>T	uc001dwq.2	+	17	2309	c.2173G>T	c.(2173-2175)GAG>TAG	p.E725*	KIAA1324_uc009wex.1_Nonsense_Mutation_p.E675*|KIAA1324_uc009wey.2_Nonsense_Mutation_p.E638*|KIAA1324_uc010ovg.1_Nonsense_Mutation_p.E623*|KIAA1324_uc001dwr.2_Nonsense_Mutation_p.E375*|KIAA1324_uc001dws.1_RNA|KIAA1324_uc009wez.1_RNA	NM_020775	NP_065826	Q6UXG2	K1324_HUMAN	hypothetical protein LOC57535 precursor	725	Extracellular (Potential).				macroautophagy|positive regulation of vacuole organization|regulation of apoptosis	integral to plasma membrane				ovary(2)|haematopoietic_and_lymphoid_tissue(1)|breast(1)|skin(1)	5		all_epithelial(167;0.000102)|all_lung(203;0.000323)|Lung NSC(277;0.00063)		Colorectal(144;0.0188)|Lung(183;0.0527)|COAD - Colon adenocarcinoma(174;0.14)|Epithelial(280;0.21)|all cancers(265;0.249)		CCGGATTCCTGAGGGTGAGTC	0.552			NA											12	107					6.42651e-13	9.20292e-13	0.000978	1	0
SYPL2	284612	broad.mit.edu	37	1	110018245	110018245	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr1:110018245G>T	uc001dxp.2	+	3	538	c.172G>T	c.(172-174)GGG>TGG	p.G58W	SYPL2_uc001dxo.2_Missense_Mutation_p.G58W|SYPL2_uc010ovk.1_Missense_Mutation_p.G58W|SYPL2_uc001dxq.2_5'Flank	NM_001040709	NP_001035799	Q5VXT5	SYPL2_HUMAN	mitsugumin 29	58	Vesicular (Potential).|MARVEL.					integral to membrane|synaptic vesicle	transporter activity			ovary(1)	1		all_epithelial(167;2.83e-05)|all_lung(203;0.00016)|Lung NSC(277;0.000318)|Breast(1374;0.244)		Colorectal(144;0.0129)|Lung(183;0.0436)|READ - Rectum adenocarcinoma(129;0.0698)|Epithelial(280;0.0808)|all cancers(265;0.0869)|LUSC - Lung squamous cell carcinoma(189;0.231)		CTCCTACAGCGGGGAGACAGG	0.527			NA											5	34					0.00116845	0.00127467	0.001168	1	0
GPR61	83873	broad.mit.edu	37	1	110085968	110085968	+	Silent	SNP	C	C	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr1:110085968C>A	uc001dxy.2	+	2	1007	c.324C>A	c.(322-324)GCC>GCA	p.A108A		NM_031936	NP_114142	Q9BZJ8	GPR61_HUMAN	G protein-coupled receptor 61	108	Extracellular (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			central_nervous_system(2)	2		all_epithelial(167;2.83e-05)|all_lung(203;0.00016)|Lung NSC(277;0.000318)|Breast(1374;0.244)		Lung(183;0.0426)|Colorectal(144;0.11)|Epithelial(280;0.128)|all cancers(265;0.132)|LUSC - Lung squamous cell carcinoma(189;0.228)		TTGACCACGCCCTCTTTGGGG	0.597			NA											14	80					7.93312e-07	9.62945e-07	0.00245	1	0
RBM15	64783	broad.mit.edu	37	1	110883749	110883749	+	Missense_Mutation	SNP	A	A	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr1:110883749A>T	uc001dzl.1	+	1	1805	c.1722A>T	c.(1720-1722)AGA>AGT	p.R574S	RBM15_uc001dzm.1_Missense_Mutation_p.R574S|uc001dzj.2_5'Flank	NM_022768	NP_073605	Q96T37	RBM15_HUMAN	RNA binding motif protein 15	574					interspecies interaction between organisms	nucleus	nucleotide binding|protein binding|RNA binding			ovary(3)	3		all_cancers(81;2.89e-06)|all_epithelial(167;2.96e-06)|all_lung(203;0.000116)|Lung NSC(277;0.000233)|Breast(1374;0.0634)		BRCA - Breast invasive adenocarcinoma(282;0.000224)|Epithelial(280;0.000476)|Kidney(133;0.000539)|KIRC - Kidney renal clear cell carcinoma(1967;0.000716)|all cancers(265;0.00144)|Lung(183;0.0238)|Colorectal(144;0.103)|LUSC - Lung squamous cell carcinoma(189;0.135)		TACTATACAGAGATCGTGATA	0.552			NA	T	MKL1	acute megakaryocytic leukemia								13	49					0	0	0.003163	0	0
MOV10	4343	broad.mit.edu	37	1	113232654	113232654	+	Missense_Mutation	SNP	A	A	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr1:113232654A>T	uc001eck.2	+	5	1040	c.770A>T	c.(769-771)AAG>ATG	p.K257M	MOV10_uc001ecl.2_Missense_Mutation_p.K257M|MOV10_uc001ecn.2_Missense_Mutation_p.K257M|MOV10_uc001ecm.2_Missense_Mutation_p.K197M|MOV10_uc009wgj.1_Missense_Mutation_p.K197M	NM_001130079	NP_001123551	Q9HCE1	MOV10_HUMAN	Mov10, Moloney leukemia virus 10, homolog	257					mRNA cleavage involved in gene silencing by miRNA|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body	ATP binding|helicase activity|protein binding|RNA binding			ovary(4)|skin(1)	5	Lung SC(450;0.246)	all_cancers(81;3.31e-11)|all_epithelial(167;5.69e-10)|all_lung(203;3.73e-05)|Breast(1374;0.000525)|Lung NSC(69;0.000954)|Ovarian(761;0.0367)|Lung SC(238;0.114)		OV - Ovarian serous cystadenocarcinoma(397;3.99e-67)|all cancers(265;1e-62)|Epithelial(280;4.78e-61)|Lung(183;0.0234)|Colorectal(144;0.0686)|READ - Rectum adenocarcinoma(129;0.0929)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)|BRCA - Breast invasive adenocarcinoma(282;0.24)		ACTCCCTTCAAGCGGACCCGG	0.617			NA											44	85					0	0	0.00361	0	0
MOV10	4343	broad.mit.edu	37	1	113242307	113242307	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr1:113242307G>C	uc001eck.2	+	18	2854	c.2584G>C	c.(2584-2586)GTG>CTG	p.V862L	MOV10_uc001ecl.2_Intron|MOV10_uc001ecn.2_Missense_Mutation_p.V862L|MOV10_uc001ecm.2_Missense_Mutation_p.V802L	NM_001130079	NP_001123551	Q9HCE1	MOV10_HUMAN	Mov10, Moloney leukemia virus 10, homolog	862					mRNA cleavage involved in gene silencing by miRNA|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body	ATP binding|helicase activity|protein binding|RNA binding			ovary(4)|skin(1)	5	Lung SC(450;0.246)	all_cancers(81;3.31e-11)|all_epithelial(167;5.69e-10)|all_lung(203;3.73e-05)|Breast(1374;0.000525)|Lung NSC(69;0.000954)|Ovarian(761;0.0367)|Lung SC(238;0.114)		OV - Ovarian serous cystadenocarcinoma(397;3.99e-67)|all cancers(265;1e-62)|Epithelial(280;4.78e-61)|Lung(183;0.0234)|Colorectal(144;0.0686)|READ - Rectum adenocarcinoma(129;0.0929)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)|BRCA - Breast invasive adenocarcinoma(282;0.24)		TCCCCACTAGGTGGGTTCAGT	0.423			NA											38	112					0	0	0.00623	0	0
MAGI3	260425	broad.mit.edu	37	1	114189213	114189213	+	Missense_Mutation	SNP	T	T	G			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr1:114189213T>G	uc001edk.2	+	12	2285	c.2104T>G	c.(2104-2106)TTG>GTG	p.L702V	MAGI3_uc001edh.3_Missense_Mutation_p.L727V|MAGI3_uc001edi.3_Missense_Mutation_p.L702V|MAGI3_uc010owm.1_Missense_Mutation_p.L727V|MAGI3_uc001edj.2_Missense_Mutation_p.L423V	NM_001142782	NP_001136254	Q5TCQ9	MAGI3_HUMAN	membrane-associated guanylate kinase-related  3	727					apoptosis|interspecies interaction between organisms|intracellular signal transduction	nucleus|tight junction	ATP binding|guanylate kinase activity|protein binding			lung(3)|ovary(2)|central_nervous_system(1)	6	Lung SC(450;0.184)	all_cancers(81;2.34e-09)|all_epithelial(167;7.41e-09)|all_lung(203;7.13e-06)|Lung NSC(69;1.2e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		ATCCCCAAAATTGGATCCTTC	0.383			NA											13	76					0	0	0.00245	0	0
SV2A	9900	broad.mit.edu	37	1	149881030	149881030	+	Silent	SNP	A	A	G			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr1:149881030A>G	uc001etg.2	-	7	1764	c.1273T>C	c.(1273-1275)TTG>CTG	p.L425L	SV2A_uc009wlk.2_5'Flank|SV2A_uc001eth.2_Silent_p.L425L	NM_014849	NP_055664	Q7L0J3	SV2A_HUMAN	synaptic vesicle glycoprotein 2	425	Cytoplasmic (Potential).				neurotransmitter transport	cell junction|endoplasmic reticulum|integral to membrane|synaptic vesicle membrane	transmembrane transporter activity			ovary(6)|pancreas(1)	7	Breast(34;0.00769)|all_hematologic(923;0.127)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.221)|STAD - Stomach adenocarcinoma(528;0.247)		Levetiracetam(DB01202)	CCTAGGCTCAAGGCCCGGACC	0.562			NA											81	61					0	0	0.00361	0	0
SLC27A3	11000	broad.mit.edu	37	1	153749049	153749049	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr1:153749049C>G	uc001fcz.2	+	2	929	c.864C>G	c.(862-864)CAC>CAG	p.H288Q	SLC27A3_uc009won.2_RNA	NM_024330	NP_077306	Q5K4L6	S27A3_HUMAN	solute carrier family 27 member 3	288					fatty acid metabolic process	integral to membrane|mitochondrial membrane	ligase activity|nucleotide binding			ovary(1)	1	all_lung(78;6.47e-32)|Lung NSC(65;2.52e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)			TGGGGCTCCACCTGTGGGCTG	0.622			NA											9	233					0	0	0.004482	0	0
ATP8B2	57198	broad.mit.edu	37	1	154317940	154317940	+	Missense_Mutation	SNP	T	T	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr1:154317940T>A	uc001fex.2	+	23	2712	c.2712T>A	c.(2710-2712)TTT>TTA	p.F904L		NM_020452	NP_065185	P98198	AT8B2_HUMAN	ATPase, class I, type 8B, member 2 isoform a	890	Helical; (Potential).				ATP biosynthetic process	plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(1)|skin(1)	2	all_lung(78;2.62e-30)|Lung NSC(65;3.94e-28)|Hepatocellular(266;0.0877)		LUSC - Lung squamous cell carcinoma(543;0.185)			TGTGCAAGTTTCTTTGCTATT	0.502			NA									OREG0013835	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	28	840					0	0	0.002836	0	0
FAM189B	10712	broad.mit.edu	37	1	155223710	155223710	+	Silent	SNP	C	C	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr1:155223710C>T	uc001fjm.2	-	4	1059	c.453G>A	c.(451-453)TCG>TCA	p.S151S	RAG1AP1_uc010pey.1_Intron|FAM189B_uc009wql.2_5'Flank|FAM189B_uc001fjn.2_Intron|FAM189B_uc001fjo.2_Silent_p.S132S|FAM189B_uc001fjp.2_Intron|FAM189B_uc001fjq.1_Silent_p.S151S	NM_006589	NP_006580	P81408	F189B_HUMAN	hypothetical protein LOC10712 isoform a	151						integral to membrane	WW domain binding			ovary(1)|breast(1)	2						GTTCCTGCCCCGACTCTGGAC	0.602			NA											48	52					0	0	0.00361	0	0
RUSC1	23623	broad.mit.edu	37	1	155298032	155298032	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr1:155298032G>C	uc001fkj.2	+	9	2735	c.2506G>C	c.(2506-2508)GAG>CAG	p.E836Q	RAG1AP1_uc010pey.1_Intron|RUSC1_uc001fkk.2_Missense_Mutation_p.E730Q|RUSC1_uc009wqn.1_RNA|RUSC1_uc009wqo.1_Missense_Mutation_p.E367Q|RUSC1_uc001fkl.2_Missense_Mutation_p.E426Q|RUSC1_uc001fkp.2_Missense_Mutation_p.E367Q|RUSC1_uc001fkq.2_Missense_Mutation_p.E261Q|RUSC1_uc010pgb.1_Missense_Mutation_p.E334Q|RUSC1_uc009wqp.1_Missense_Mutation_p.E361Q|RUSC1_uc001fkn.2_Missense_Mutation_p.E145Q|RUSC1_uc001fko.2_RNA|RUSC1_uc001fkr.2_Missense_Mutation_p.E367Q|RUSC1_uc001fks.2_Intron	NM_001105203	NP_001098673	Q9BVN2	RUSC1_HUMAN	RUN and SH3 domain containing 1 isoform a	836						cytoplasm|nucleolus	SH3/SH2 adaptor activity			ovary(2)	2	Hepatocellular(266;0.0877)|all_hematologic(923;0.145)		Epithelial(20;1.55e-10)|all cancers(21;4.15e-10)|BRCA - Breast invasive adenocarcinoma(34;0.000549)|LUSC - Lung squamous cell carcinoma(543;0.127)			TCAGGAGCTTGAGGCCTCAGC	0.547			NA											14	234					0	0	0.007413	0	0
DAP3	7818	broad.mit.edu	37	1	155701746	155701746	+	Silent	SNP	C	C	G			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr1:155701746C>G	uc001flq.2	+	11	1084	c.915C>G	c.(913-915)GCC>GCG	p.A305A	DAP3_uc001flr.2_Silent_p.A305A|DAP3_uc001fls.2_Silent_p.A305A|DAP3_uc010pgl.1_Silent_p.A264A|DAP3_uc001flt.2_Silent_p.A271A|DAP3_uc001flu.2_Silent_p.A278A|DAP3_uc010pgm.1_Silent_p.A271A	NM_033657	NP_387506	P51398	RT29_HUMAN	death-associated protein 3	305					induction of apoptosis by extracellular signals	mitochondrial ribosome|nucleolus|small ribosomal subunit	protein binding			ovary(1)	1	Hepatocellular(266;0.0997)|all_hematologic(923;0.145)					ATGGAGGCGCCATTGTGTCGG	0.423			NA											6	25					0	0	0.001168	0	0
IQGAP3	128239	broad.mit.edu	37	1	156501027	156501027	+	Silent	SNP	C	C	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr1:156501027C>A	uc001fpf.2	-	33	4191	c.4116G>T	c.(4114-4116)CTG>CTT	p.L1372L		NM_178229	NP_839943	Q86VI3	IQGA3_HUMAN	IQ motif containing GTPase activating protein 3	1372					small GTPase mediated signal transduction	intracellular	calmodulin binding|Ras GTPase activator activity			ovary(5)|skin(1)	6	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					TATCGGCCAACAGCTGCTTGG	0.597			NA											23	121					9.57634e-11	1.31762e-10	0.00333	1	0
FCRL5	83416	broad.mit.edu	37	1	157485511	157485512	+	Missense_Mutation	DNP	GG	GG	TT	rs140845798	byFrequency	TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr1:157485511_157485512GG>TT	uc001fqu.2	-	17	3045_3046	c.2887_2888CC>AA	c.(2887-2889)CCG>AAG	p.P963K	FCRL5_uc009wsm.2_Silent_p.959_960PR>PR	NM_031281	NP_112571	Q96RD9	FCRL5_HUMAN	Fc receptor-like 5	963	Cytoplasmic (Potential).					integral to membrane|plasma membrane	receptor activity			ovary(3)|breast(2)|central_nervous_system(1)	6	all_hematologic(112;0.0378)|Hepatocellular(266;0.178)	Prostate(1639;0.231)				TCCGGAAACCGGGGTTGACGCC	0.584			NA											41	509					0	0	0.004672	0	0
OR10T2	128360	broad.mit.edu	37	1	158368475	158368475	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr1:158368475C>A	uc010pih.1	-	1	782	c.782G>T	c.(781-783)CGG>CTG	p.R261L		NM_001004475	NP_001004475	Q8NGX3	O10T2_HUMAN	olfactory receptor, family 10, subfamily T,	261	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|central_nervous_system(1)	3	all_hematologic(112;0.0378)					GGACTTGGGCCGCAGATAGAT	0.512			NA											9	67					3.86212e-05	4.43255e-05	0.008291	1	0
OR6K3	391114	broad.mit.edu	37	1	158687103	158687103	+	Missense_Mutation	SNP	A	A	G			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr1:158687103A>G	uc010pip.1	-	1	851	c.851T>C	c.(850-852)GTT>GCT	p.V284A		NM_001005327	NP_001005327	Q8NGY3	OR6K3_HUMAN	olfactory receptor, family 6, subfamily K,	284	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|kidney(1)|central_nervous_system(1)	3	all_hematologic(112;0.0378)					TGTGTCCAAAACTGGTGGATA	0.433			NA											4	223					0	0	0.009096	0	0
CADM3	57863	broad.mit.edu	37	1	159166690	159166690	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr1:159166690G>T	uc001ftl.2	+	7	934	c.792G>T	c.(790-792)CAG>CAT	p.Q264H	CADM3_uc009wsy.1_Missense_Mutation_p.Q218H|CADM3_uc001ftk.2_Missense_Mutation_p.Q298H|uc001ftm.1_RNA	NM_001127173	NP_001120645	Q8N126	CADM3_HUMAN	cell adhesion molecule 3 isoform 2	264	Ig-like C2-type 2.|Extracellular (Potential).				adherens junction organization|cell junction assembly|heterophilic cell-cell adhesion|homophilic cell adhesion	cell-cell junction|integral to membrane	protein homodimerization activity			ovary(2)	2	all_hematologic(112;0.0429)					GCCCCCAGCAGTACCTATGGG	0.527			NA											15	203					2.23348e-06	2.66668e-06	0.004007	1	0
DARC	2532	broad.mit.edu	37	1	159175860	159175860	+	Missense_Mutation	SNP	A	A	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr1:159175860A>T	uc001fto.2	+	2	871	c.631A>T	c.(631-633)ACT>TCT	p.T211S	DARC_uc001ftp.3_Missense_Mutation_p.T213S	NM_002036	NP_002027	Q16570	DUFFY_HUMAN	Duffy blood group antigen isoform b	211	Helical; Name=5; (Potential).				defense response	integral to membrane|plasma membrane	C-C chemokine binding|chemokine receptor activity			ovary(1)|lung(1)	2	all_hematologic(112;0.0429)					GGCCACACACACTGTAGCCTG	0.562			NA											9	146					0	0	0.008291	0	0
NHLH1	4807	broad.mit.edu	37	1	160340530	160340530	+	Silent	SNP	C	C	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr1:160340530C>T	uc001fwa.2	+	2	451	c.9C>T	c.(7-9)CTC>CTT	p.L3L		NM_005598	NP_005589	Q02575	HEN1_HUMAN	nescient helix loop helix 1	3					cell differentiation|central nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(1)	1	all_cancers(52;7.11e-19)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			TCATGATGCTCAACTCAGACA	0.662			NA											27	25					0	0	0.003271	0	0
CD84	8832	broad.mit.edu	37	1	160523869	160523869	+	Silent	SNP	T	T	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr1:160523869T>A	uc001fwh.3	-	3	480	c.456A>T	c.(454-456)ACA>ACT	p.T152T	CD84_uc001fwf.3_Silent_p.T152T|CD84_uc001fwg.3_Silent_p.T152T|CD84_uc009wtn.2_Silent_p.T152T|CD84_uc001fwi.3_Silent_p.T38T|CD84_uc001fwj.2_Silent_p.T152T|CD84_uc001fwk.2_Silent_p.T152T	NM_003874	NP_003865	Q9UIB8	SLAF5_HUMAN	CD84 molecule	152	Extracellular (Potential).|Ig-like C2-type.				blood coagulation|defense response|homophilic cell adhesion|leukocyte migration	integral to plasma membrane	receptor activity			ovary(2)|central_nervous_system(1)|skin(1)	4	all_cancers(52;3.62e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.0175)			AGCATGTCAGTGTGACATTAC	0.433			NA											11	286					0	0	0.001368	0	0
OLFML2B	25903	broad.mit.edu	37	1	161967727	161967727	+	Silent	SNP	G	G	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr1:161967727G>A	uc001gbu.2	-	6	1786	c.1362C>T	c.(1360-1362)CCC>CCT	p.P454P	OLFML2B_uc010pkq.1_Silent_p.P455P	NM_015441	NP_056256	Q68BL8	OLM2B_HUMAN	olfactomedin-like 2B precursor	454										skin(1)	1	all_hematologic(112;0.156)		BRCA - Breast invasive adenocarcinoma(70;0.0172)			TGACTGTGGTGGGAGGCACTG	0.622			NA											24	322					0	0	0.009535	0	0
DUSP27	92235	broad.mit.edu	37	1	167095983	167095983	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr1:167095983G>T	uc001geb.1	+	5	1615	c.1615G>T	c.(1615-1617)GAC>TAC	p.D539Y		NM_001080426	NP_001073895	Q5VZP5	DUS27_HUMAN	dual specificity phosphatase 27	539					protein dephosphorylation		protein tyrosine/serine/threonine phosphatase activity			ovary(3)	3						CAGGAACAAGGACAAGCTCAC	0.552			NA											26	218					1.5548e-18	2.35832e-18	0.005443	1	0
F5	2153	broad.mit.edu	37	1	169484771	169484771	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr1:169484771C>G	uc001ggg.1	-	24	6584	c.6439G>C	c.(6439-6441)GAA>CAA	p.E2147Q		NM_000130	NP_000121	P12259	FA5_HUMAN	coagulation factor V precursor	2147	F5/8 type C 2.				cell adhesion|platelet activation|platelet degranulation	plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity			ovary(3)|large_intestine(1)|central_nervous_system(1)|skin(1)	6	all_hematologic(923;0.208)				Drotrecogin alfa(DB00055)	ACATACATTTCAGAGGACAGA	0.433			NA											28	297					0	0	0.004656	0	0
F5	2153	broad.mit.edu	37	1	169515796	169515796	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr1:169515796G>A	uc001ggg.1	-	11	1791	c.1646C>T	c.(1645-1647)GCT>GTT	p.A549V	F5_uc010plr.1_RNA	NM_000130	NP_000121	P12259	FA5_HUMAN	coagulation factor V precursor	549	Plastocyanin-like 4.|F5/8 type A 2.				cell adhesion|platelet activation|platelet degranulation	plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity			ovary(3)|large_intestine(1)|central_nervous_system(1)|skin(1)	6	all_hematologic(923;0.208)				Drotrecogin alfa(DB00055)	ATCAAACACAGCAAACACAGC	0.318			NA											14	176					0	0	0.003163	0	0
PAPPA2	60676	broad.mit.edu	37	1	176661380	176661380	+	Silent	SNP	T	T	C			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr1:176661380T>C	uc001gkz.2	+	6	3714	c.2550T>C	c.(2548-2550)CCT>CCC	p.P850P	PAPPA2_uc009www.2_RNA	NM_020318	NP_064714	Q9BXP8	PAPP2_HUMAN	pappalysin 2 isoform 1	850					cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			ovary(7)|central_nervous_system(5)|skin(2)|lung(1)|breast(1)	16						CCATTCCACCTATGGTCATCG	0.517			NA											46	253					0	0	0.00361	0	0
RASAL2	9462	broad.mit.edu	37	1	178426890	178426890	+	Silent	SNP	G	G	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr1:178426890G>T	uc001glr.2	+	12	2165	c.2040G>T	c.(2038-2040)CTG>CTT	p.L680L	RASAL2_uc001glq.2_Silent_p.L821L|RASAL2_uc009wxc.2_Silent_p.L194L	NM_004841	NP_004832	Q9UJF2	NGAP_HUMAN	RAS protein activator like 2 isoform 1	680					negative regulation of Ras protein signal transduction|signal transduction	cytoplasm|intrinsic to internal side of plasma membrane	Ras GTPase activator activity			ovary(2)|breast(2)|large_intestine(1)	5						CATTATTGCTGGTTCAGCAAG	0.448			NA											17	160					3.41278e-10	4.64178e-10	0.00499	1	0
TOR1AIP1	26092	broad.mit.edu	37	1	179887338	179887338	+	Missense_Mutation	SNP	A	A	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr1:179887338A>T	uc001gnq.2	+	10	1934	c.1716A>T	c.(1714-1716)CAA>CAT	p.Q572H		NM_015602	NP_056417	Q5JTV8	TOIP1_HUMAN	lamina-associated polypeptide 1B	572	Lumenal (Potential).					integral to membrane|nuclear inner membrane				breast(1)|central_nervous_system(1)	2						TGCCTGTGCAACCTGAAAATG	0.433			NA											14	126					0	0	0.007413	0	0
LHX4	89884	broad.mit.edu	37	1	180243566	180243566	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr1:180243566C>G	uc001goe.1	+	6	1248	c.1025C>G	c.(1024-1026)GCG>GGG	p.A342G	uc001gof.1_Intron	NM_033343	NP_203129	Q969G2	LHX4_HUMAN	LIM homeobox protein 4	342						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1						GGCATCATTGCGCATGCAGGG	0.572			NA											87	447					0	0	0.00361	0	0
CACNA1E	777	broad.mit.edu	37	1	181741231	181741231	+	Missense_Mutation	SNP	T	T	C			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr1:181741231T>C	uc001gow.2	+	37	5168	c.5003T>C	c.(5002-5004)ATT>ACT	p.I1668T	CACNA1E_uc009wxs.2_Missense_Mutation_p.I1556T|CACNA1E_uc001gox.1_Missense_Mutation_p.I894T|CACNA1E_uc009wxt.2_Missense_Mutation_p.I894T	NM_000721	NP_000712	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type,	1668	Extracellular (Potential).|IV.				energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(3)|central_nervous_system(2)|pancreas(1)	6						TGGCAGGAGATTATGCTGTCA	0.567			NA											48	63					0	0	0.00361	0	0
ZNF648	127665	broad.mit.edu	37	1	182025857	182025857	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr1:182025857G>A	uc001goz.2	-	2	1497	c.1289C>T	c.(1288-1290)ACC>ATC	p.T430I		NM_001009992	NP_001009992	Q5T619	ZN648_HUMAN	zinc finger protein 648	430	C2H2-type 6.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						GGAGGACTTGGTGAAGCACTT	0.692	NSCLC(71;908 1374 5429 20458 35642)		NA											3	8					0	0	0.004672	0	0
PRG4	10216	broad.mit.edu	37	1	186270816	186270816	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr1:186270816C>G	uc001gru.3	+	4	343	c.292C>G	c.(292-294)CCC>GCC	p.P98A	PRG4_uc001grt.3_Missense_Mutation_p.P57A|PRG4_uc009wyl.2_Missense_Mutation_p.P98A|PRG4_uc009wym.2_Missense_Mutation_p.P57A|PRG4_uc010poo.1_RNA	NM_005807	NP_005798	Q92954	PRG4_HUMAN	proteoglycan 4 isoform A	98	SMB 2.				cell proliferation|immune response	extracellular region	polysaccharide binding|protein binding|scavenger receptor activity			skin(1)	1						CAAGTGCTGTCCCGATTATGA	0.493			NA											19	96					0	0	0.007413	0	0
PLA2G4A	5321	broad.mit.edu	37	1	186909161	186909161	+	Missense_Mutation	SNP	A	A	C			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr1:186909161A>C	uc001gsc.2	+	10	1173	c.968A>C	c.(967-969)CAA>CCA	p.Q323P	PLA2G4A_uc010pos.1_Missense_Mutation_p.Q263P	NM_024420	NP_077734	P47712	PA24A_HUMAN	cytosolic phospholipase A2, group IVA	323	PLA2c.				phospholipid catabolic process|platelet activating factor biosynthetic process|platelet activation	cytosol|endoplasmic reticulum membrane	calcium ion binding|calcium-dependent phospholipid binding|lysophospholipase activity			lung(2)|breast(1)	3					Flunisolide(DB00180)|Fluocinolone Acetonide(DB00591)|Fluocinonide(DB01047)|Fluorometholone(DB00324)|Flurandrenolide(DB00846)|Fluticasone Propionate(DB00588)|Medrysone(DB00253)|Quinacrine(DB01103)	AATACTGCACAATGCCCTTTA	0.383			NA											17	138					0	0	0.007413	0	0
FAM5C	339479	broad.mit.edu	37	1	190233997	190233997	+	Missense_Mutation	SNP	T	T	C			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr1:190233997T>C	uc001gse.1	-	4	848	c.616A>G	c.(616-618)AAG>GAG	p.K206E	FAM5C_uc010pot.1_Missense_Mutation_p.K104E	NM_199051	NP_950252	Q76B58	FAM5C_HUMAN	family with sequence similarity 5, member C	206						extracellular region				lung(2)|ovary(1)|kidney(1)|skin(1)	5	Prostate(682;0.198)					ATTCTTACCTTTATGGCAGTG	0.388			NA											40	82					0	0	0.00361	0	0
KCNT2	343450	broad.mit.edu	37	1	196309513	196309513	+	Nonsense_Mutation	SNP	C	C	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr1:196309513C>A	uc001gtd.1	-	16	1801	c.1741G>T	c.(1741-1743)GGA>TGA	p.G581*	KCNT2_uc009wyt.1_RNA|KCNT2_uc001gte.1_Nonsense_Mutation_p.G531*|KCNT2_uc001gtf.1_Nonsense_Mutation_p.G581*|KCNT2_uc001gtg.1_RNA|KCNT2_uc009wyu.2_Nonsense_Mutation_p.G581*|KCNT2_uc001gth.1_Nonsense_Mutation_p.G102*	NM_198503	NP_940905	Q6UVM3	KCNT2_HUMAN	potassium channel, subfamily T, member 2	581	Cytoplasmic (Potential).					voltage-gated potassium channel complex	ATP binding|calcium-activated potassium channel activity|voltage-gated potassium channel activity			ovary(5)|breast(1)|skin(1)	7						CTGGAAGGTCCATGATAAAAC	0.284			NA											4	151					0.000602214	0.000665384	0.000602	1	0
ASPM	259266	broad.mit.edu	37	1	197072642	197072642	+	Silent	SNP	G	G	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr1:197072642G>A	uc001gtu.2	-	18	5996	c.5739C>T	c.(5737-5739)GCC>GCT	p.A1913A	ASPM_uc001gtv.2_Intron|ASPM_uc001gtw.3_Intron	NM_018136	NP_060606	Q8IZT6	ASPM_HUMAN	asp (abnormal spindle)-like, microcephaly	1913	IQ 11.				mitosis	cytoplasm|nucleus	calmodulin binding			ovary(4)|central_nervous_system(2)	6						ACTGTTTCTGGGCCTTGGCCA	0.438			NA											33	170					0	0	0.002096	0	0
CAMSAP1L1	23271	broad.mit.edu	37	1	200817337	200817337	+	Silent	SNP	A	A	G			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr1:200817337A>G	uc001gvl.2	+	12	1743	c.1473A>G	c.(1471-1473)GAA>GAG	p.E491E	CAMSAP1L1_uc001gvk.2_Silent_p.E480E|CAMSAP1L1_uc001gvm.2_Silent_p.E464E	NM_203459	NP_982284	Q08AD1	CAMP2_HUMAN	calmodulin regulated spectrin-associated protein	491						cytoplasm|microtubule	protein binding			ovary(2)|large_intestine(1)|pancreas(1)	4						TAAATGGAGAAGAGGAAGCAG	0.353			NA											12	72					0	0	0.001855	0	0
ELK4	2005	broad.mit.edu	37	1	205589269	205589269	+	Missense_Mutation	SNP	T	T	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr1:205589269T>A	uc001hcy.1	-	3	2155	c.905A>T	c.(904-906)GAC>GTC	p.D302V	ELK4_uc001hcz.2_Missense_Mutation_p.D302V	NM_001973	NP_001964	P28324	ELK4_HUMAN	ELK4 protein isoform a	302						cytoplasm|nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription cofactor activity				0	Breast(84;0.07)		BRCA - Breast invasive adenocarcinoma(75;0.0908)			TGAATCCTGGTCTTTAGGCTC	0.458			NA	T	SLC45A3	prostate								12	224					0	0	0.000978	0	0
SRGAP2	23380	broad.mit.edu	37	1	206566979	206566979	+	Silent	SNP	C	C	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr1:206566979C>T	uc001hdy.2	+	4	852	c.519C>T	c.(517-519)ACC>ACT	p.T173T	SRGAP2_uc009xbt.2_Silent_p.T97T|SRGAP2_uc010prt.1_Silent_p.T97T|SRGAP2_uc001hdx.2_Silent_p.T173T|SRGAP2_uc010pru.1_Silent_p.T97T|SRGAP2_uc010prv.1_Silent_p.T97T	NM_015326	NP_056141	O75044	FNBP2_HUMAN	SLIT-ROBO Rho GTPase activating protein 2	260					axon guidance|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|protein binding				0	Breast(84;0.137)					TGGAGGCAACCAATGCATCTG	0.468			NA											14	126					0	0	0.001855	0	0
CR1L	1379	broad.mit.edu	37	1	207890857	207890857	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr1:207890857G>C	uc001hga.3	+	11	1584	c.1463G>C	c.(1462-1464)GGA>GCA	p.G488A	CR1L_uc001hfz.2_RNA|CR1L_uc001hgb.1_RNA	NM_175710	NP_783641	Q2VPA4	CR1L_HUMAN	complement component (3b/4b) receptor 1-like	488	Sushi 8.					cytoplasm|extracellular region|membrane					0						AGACACACAGGAACTCCCCTT	0.428			NA											5	179					0	0	0.000602	0	0
HSD11B1	3290	broad.mit.edu	37	1	209878314	209878314	+	Silent	SNP	C	C	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr1:209878314C>A	uc001hhj.2	+	2	134	c.27C>A	c.(25-27)CTC>CTA	p.L9L	HSD11B1_uc001hhk.2_Silent_p.L9L	NM_181755	NP_861420	P28845	DHI1_HUMAN	11-beta-hydroxysteroid dehydrogenase 1	9	Helical; Signal-anchor for type II membrane protein; (Potential).				glucocorticoid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	11-beta-hydroxysteroid dehydrogenase (NADP+) activity|11-beta-hydroxysteroid dehydrogenase|binding			breast(1)	1				OV - Ovarian serous cystadenocarcinoma(81;1.04e-55)|Epithelial(68;1.57e-52)|all cancers(67;1.83e-46)|Colorectal(1306;0.115)	NADH(DB00157)	AATATCTCCTCCCCATTCTGG	0.463			NA											16	124					1.3612e-06	1.64594e-06	0.003163	1	0
IRF6	3664	broad.mit.edu	37	1	209974608	209974608	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr1:209974608C>T	uc001hhq.1	-	3	414	c.151G>A	c.(151-153)GAA>AAA	p.E51K	IRF6_uc010psm.1_Intron|IRF6_uc009xct.1_Missense_Mutation_p.E51K	NM_006147	NP_006138	O14896	IRF6_HUMAN	interferon regulatory factor 6	51	IRF tryptophan pentad repeat.				cell cycle arrest|interferon-gamma-mediated signaling pathway|mammary gland epithelial cell differentiation|negative regulation of cell proliferation|positive regulation of transcription, DNA-dependent|type I interferon-mediated signaling pathway	cytoplasm|nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(2)	2				OV - Ovarian serous cystadenocarcinoma(81;0.0351)		TTTTCCTCTTCTTGTTGAGGG	0.438			NA								HNSCC(57;0.16)			9	204					0	0	0.000978	0	0
CENPF	1063	broad.mit.edu	37	1	214819878	214819878	+	Missense_Mutation	SNP	A	A	C			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr1:214819878A>C	uc001hkm.2	+	13	7139	c.6965A>C	c.(6964-6966)CAA>CCA	p.Q2322P		NM_016343	NP_057427	P49454	CENPF_HUMAN	centromere protein F	2418	2-2.|Interaction with NDE1 and NDEL1.|Potential.|2 X 177 AA tandem repeats.				cell differentiation|cell division|cell proliferation|DNA replication|G2 phase of mitotic cell cycle|kinetochore assembly|metaphase plate congression|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|muscle organ development|negative regulation of transcription, DNA-dependent|protein transport|regulation of G2/M transition of mitotic cell cycle|regulation of striated muscle tissue development|response to drug	condensed chromosome outer kinetochore|cytosol|midbody|nuclear envelope|nuclear matrix|perinuclear region of cytoplasm|spindle pole	chromatin binding|dynein binding|protein C-terminus binding|protein homodimerization activity|transcription factor binding			ovary(6)|central_nervous_system(4)|large_intestine(2)|skin(1)	13				all cancers(67;0.00836)|OV - Ovarian serous cystadenocarcinoma(81;0.00855)|GBM - Glioblastoma multiforme(131;0.0694)|Epithelial(68;0.0833)		TGTGTCTTACAACAACTGAAG	0.453	Colon(80;575 1284 11000 14801 43496)		NA											9	160					0	0	0.000978	0	0
USH2A	7399	broad.mit.edu	37	1	216166438	216166438	+	Silent	SNP	G	G	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr1:216166438G>A	uc001hku.1	-	35	7116	c.6729C>T	c.(6727-6729)GGC>GGT	p.G2243G		NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	2243	Fibronectin type-III 9.|Extracellular (Potential).				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		GGGCTGGCACGCCTTCGGGTA	0.507			NA								HNSCC(13;0.011)	OREG0014251	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	33	298					0	0	0.003755	0	0
RAB3GAP2	25782	broad.mit.edu	37	1	220345290	220345290	+	Missense_Mutation	SNP	A	A	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr1:220345290A>T	uc010puk.1	-	23	2682	c.2518T>A	c.(2518-2520)TCT>ACT	p.S840T	RAB3GAP2_uc001hmf.2_RNA|RAB3GAP2_uc001hmg.2_Missense_Mutation_p.S420T	NM_012414	NP_036546	Q9H2M9	RBGPR_HUMAN	rab3 GTPase-activating protein, non-catalytic	840					intracellular protein transport	cytoplasm|soluble fraction	GTPase activator activity|protein heterodimerization activity			central_nervous_system(1)	1				GBM - Glioblastoma multiforme(131;0.0443)		ACATGCGCAGACAACAGAGCG	0.493			NA											50	59					0	0	0.00361	0	0
DEGS1	8560	broad.mit.edu	37	1	224378005	224378005	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr1:224378005G>C	uc001hoj.2	+	2	920	c.809G>C	c.(808-810)GGA>GCA	p.G270A	DEGS1_uc001hoi.2_Missense_Mutation_p.G249A	NM_144780	NP_659004	O15121	DEGS1_HUMAN	degenerative spermatocyte homolog 1, lipid	270					sphingolipid metabolic process|unsaturated fatty acid biosynthetic process	endoplasmic reticulum membrane|integral to plasma membrane|membrane fraction	electron carrier activity|protein binding|sphingolipid delta-4 desaturase activity				0	Breast(184;0.193)			GBM - Glioblastoma multiforme(131;0.00643)		AACATTCCTGGAAAAAGTCTT	0.249			NA											4	129					0	0	0.009096	0	0
PSEN2	5664	broad.mit.edu	37	1	227073239	227073239	+	Silent	SNP	C	C	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr1:227073239C>T	uc009xeo.1	+	6	784	c.357C>T	c.(355-357)CTC>CTT	p.L119L	PSEN2_uc009xep.1_Silent_p.L119L|PSEN2_uc001hqk.2_RNA	NM_000447	NP_000438	P49810	PSN2_HUMAN	presenilin 2 isoform 1	119	Lumenal (Potential).				amyloid precursor protein catabolic process|anti-apoptosis|apoptosis|beta-amyloid metabolic process|calcium ion transport|induction of apoptosis by extracellular signals|intracellular signal transduction|membrane protein ectodomain proteolysis|membrane protein intracellular domain proteolysis|nerve growth factor receptor signaling pathway|Notch receptor processing|Notch signaling pathway|positive regulation of catalytic activity	apical plasma membrane|axon|cell cortex|cell surface|centrosome|ciliary rootlet|dendritic shaft|endoplasmic reticulum membrane|Golgi membrane|growth cone|integral to plasma membrane|kinetochore|lysosomal membrane|membrane raft|mitochondrial inner membrane|neuromuscular junction|neuronal cell body|nuclear inner membrane|perinuclear region of cytoplasm|Z disc	aspartic-type endopeptidase activity|protein binding			lung(2)	2		Prostate(94;0.0771)				TCTCCCTCAGCATCTACACGC	0.597			NA											17	19					0	0	0.00499	0	0
JMJD4	65094	broad.mit.edu	37	1	227922419	227922419	+	Nonsense_Mutation	SNP	C	C	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr1:227922419C>A	uc001hrb.2	-	2	499	c.499G>T	c.(499-501)GAG>TAG	p.E167*	SNAP47_uc001hqz.2_Intron|SNAP47_uc001hra.2_Intron|SNAP47_uc001hrd.2_5'Flank|SNAP47_uc001hre.2_5'Flank|SNAP47_uc001hrf.2_5'Flank|JMJD4_uc001hrc.2_Nonsense_Mutation_p.E167*	NM_023007	NP_075383	Q9H9V9	JMJD4_HUMAN	jumonji domain containing 4 isoform 1	167											0		Prostate(94;0.0885)				TGTATGTACTCTTTCCAGTAG	0.552			NA											11	113					2.31682e-05	2.68831e-05	0.003163	1	0
SIPA1L2	57568	broad.mit.edu	37	1	232607141	232607141	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr1:232607141G>T	uc001hvg.2	-	6	2377	c.2219C>A	c.(2218-2220)CCA>CAA	p.P740Q		NM_020808	NP_065859	Q9P2F8	SI1L2_HUMAN	signal-induced proliferation-associated 1 like	740	Rap-GAP.				regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			ovary(2)|central_nervous_system(2)|pancreas(1)|skin(1)	6		all_cancers(173;0.00605)|Prostate(94;0.128)|all_epithelial(177;0.186)				TTCGGTACATGGATTATGCAC	0.433			NA											46	283					9.22156e-22	1.45217e-21	0.00361	1	0
SIPA1L2	57568	broad.mit.edu	37	1	232626781	232626781	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr1:232626781C>G	uc001hvg.2	-	3	1803	c.1645G>C	c.(1645-1647)GAA>CAA	p.E549Q		NM_020808	NP_065859	Q9P2F8	SI1L2_HUMAN	signal-induced proliferation-associated 1 like	549					regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			ovary(2)|central_nervous_system(2)|pancreas(1)|skin(1)	6		all_cancers(173;0.00605)|Prostate(94;0.128)|all_epithelial(177;0.186)				ATAGCATCTTCTAAAATTGCT	0.423			NA											14	43					0	0	0.00499	0	0
EDARADD	128178	broad.mit.edu	37	1	236631557	236631557	+	Silent	SNP	C	C	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr1:236631557C>T	uc001hxu.1	+	5	311	c.246C>T	c.(244-246)AGC>AGT	p.S82S	EDARADD_uc001hxv.1_Silent_p.S72S	NM_145861	NP_665860	Q8WWZ3	EDAD_HUMAN	EDAR-associated death domain isoform A	82					cell differentiation|signal transduction	cytoplasm					0	Ovarian(103;0.0634)|Breast(184;0.247)	all_cancers(173;0.0232)|Prostate(94;0.174)	OV - Ovarian serous cystadenocarcinoma(106;0.00117)			TTCCAGATAGCACTGGAGATC	0.318			NA											29	114					0	0	0.002096	0	0
ACTN2	88	broad.mit.edu	37	1	236912564	236912564	+	Silent	SNP	G	G	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr1:236912564G>A	uc001hyf.2	+	14	1860	c.1656G>A	c.(1654-1656)CAG>CAA	p.Q552Q	ACTN2_uc001hyg.2_Silent_p.Q344Q|ACTN2_uc009xgi.1_Silent_p.Q552Q|ACTN2_uc010pxu.1_Silent_p.Q241Q|ACTN2_uc001hyh.2_Silent_p.Q240Q	NM_001103	NP_001094	P35609	ACTN2_HUMAN	actinin, alpha 2	552	Spectrin 3.				focal adhesion assembly|microspike assembly|muscle filament sliding|platelet activation|platelet degranulation|protein homotetramerization|regulation of apoptosis|synaptic transmission	actin filament|cytosol|dendritic spine|extracellular region|filopodium|focal adhesion|nucleolus|platelet alpha granule lumen|pseudopodium|Z disc	actin binding|calcium ion binding|FATZ 1 binding|identical protein binding|integrin binding|protein dimerization activity|structural constituent of muscle|titin binding|titin Z domain binding|ZASP binding			ovary(4)|skin(1)	5	Ovarian(103;0.0634)|Breast(184;0.221)	all_cancers(173;0.00661)|Acute lymphoblastic leukemia(190;0.109)|Prostate(94;0.174)	OV - Ovarian serous cystadenocarcinoma(106;0.00168)			AGGAGATCCAGGTAATGGAAC	0.423			NA											4	82					0	0	0.009096	0	0
RYR2	6262	broad.mit.edu	37	1	237942011	237942011	+	Missense_Mutation	SNP	T	T	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr1:237942011T>A	uc001hyl.1	+	88	11941	c.11821T>A	c.(11821-11823)TGG>AGG	p.W3941R	RYR2_uc010pya.1_Missense_Mutation_p.W356R	NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	3941	Helical; Name=M1; (Potential).				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			CAGCAGGCTGTGGGATGCTGT	0.448			NA											10	95					0	0	0.000978	0	0
RYR2	6262	broad.mit.edu	37	1	237965182	237965182	+	Missense_Mutation	SNP	A	A	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr1:237965182A>T	uc001hyl.1	+	98	14237	c.14117A>T	c.(14116-14118)CAG>CTG	p.Q4706L	RYR2_uc010pyb.1_Missense_Mutation_p.Q139L	NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	4706					cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			GTGAAGTATCAGATGTGGAAA	0.398			NA											3	40					0	0	0.004672	0	0
RYR2	6262	broad.mit.edu	37	1	237982399	237982399	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr1:237982399G>C	uc001hyl.1	+	101	14617	c.14497G>C	c.(14497-14499)GAC>CAC	p.D4833H	RYR2_uc010pyb.1_Missense_Mutation_p.D266H	NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	4833					cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			TGAAATCGAAGACCCAGCAGG	0.413			NA											24	92					0	0	0.00278	0	0
ZP4	57829	broad.mit.edu	37	1	238053192	238053192	+	Silent	SNP	C	C	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr1:238053192C>A	uc001hym.2	-	3	375	c.375G>T	c.(373-375)CTG>CTT	p.L125L	LOC100130331_uc010pyc.1_Intron	NM_021186	NP_067009	Q12836	ZP4_HUMAN	zona pellucida glycoprotein 4 preproprotein	125	Extracellular (Potential).				acrosomal vesicle exocytosis|negative regulation of binding of sperm to zona pellucida|positive regulation of acrosome reaction|positive regulation of humoral immune response|positive regulation of protein kinase activity|positive regulation of T cell proliferation|protein kinase A signaling cascade|protein kinase C signaling cascade	integral to membrane|intracellular|plasma membrane|proteinaceous extracellular matrix	acrosin binding|receptor activity			ovary(2)|skin(1)	3	Ovarian(103;0.103)	all_cancers(173;0.00175)|all_epithelial(177;0.162)|all_neural(198;0.164)|Melanoma(53;0.211)|Prostate(94;0.214)	OV - Ovarian serous cystadenocarcinoma(106;0.00989)			GACACTTGAGCAGCTTCCTCT	0.562	NSCLC(166;160 2029 11600 18754 19936)		NA											14	511					1.5739e-10	2.1624e-10	0.004007	1	0
FMN2	56776	broad.mit.edu	37	1	240370957	240370957	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr1:240370957C>T	uc010pyd.1	+	5	3070	c.2845C>T	c.(2845-2847)CCC>TCC	p.P949S	FMN2_uc010pye.1_Missense_Mutation_p.P953S	NM_020066	NP_064450	Q9NZ56	FMN2_HUMAN	formin 2	949	Pro-rich.|FH1.				actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			ovary(4)|pancreas(3)|skin(3)|large_intestine(1)|central_nervous_system(1)	12	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			GCCCCCTCTACCCGGAGCGGC	0.692			NA											12	61					0	0	0.004007	0	0
SMYD3	64754	broad.mit.edu	37	1	245912930	245912930	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr1:245912930G>T	uc001ibl.2	-	12	1317	c.1222C>A	c.(1222-1224)CAC>AAC	p.H408N	SMYD3_uc001ibk.2_Missense_Mutation_p.H349N|SMYD3_uc001ibi.2_3'UTR|SMYD3_uc001ibj.2_Missense_Mutation_p.H219N	NM_022743	NP_073580	Q9H7B4	SMYD3_HUMAN	SET and MYND domain containing 3	408						cytoplasm|nucleus	histone-lysine N-methyltransferase activity|protein binding|zinc ion binding				0	all_cancers(71;0.000291)|all_epithelial(71;0.000174)|Ovarian(71;0.0377)|all_lung(81;0.0568)|Lung NSC(105;0.0804)|Breast(184;0.173)|Melanoma(84;0.242)	all_cancers(173;0.0496)|Acute lymphoblastic leukemia(190;0.164)	OV - Ovarian serous cystadenocarcinoma(106;0.0129)	all cancers(4;0.028)|GBM - Glioblastoma multiforme(49;0.0537)		ATCAGGCTGTGTTCTCTGCCA	0.463			NA											11	71					6.42651e-13	9.20292e-13	0.000978	1	0
OR2W5	441932	broad.mit.edu	37	1	247654812	247654812	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr1:247654812G>T	uc001icz.1	+	1	383	c.383G>T	c.(382-384)CGG>CTG	p.R128L		NM_001004698	NP_001004698	A6NFC9	OR2W5_HUMAN	olfactory receptor, family 2, subfamily W,	128					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|breast(1)|skin(1)	3	all_cancers(71;4.51e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.222)	OV - Ovarian serous cystadenocarcinoma(106;0.0188)			GCCGTCTGCCGGTCCCTGCAC	0.587			NA											63	58					1.1397e-45	1.89884e-45	0.00361	1	0
OR2G2	81470	broad.mit.edu	37	1	247752015	247752015	+	Silent	SNP	G	G	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr1:247752015G>T	uc010pyy.1	+	1	354	c.354G>T	c.(352-354)CCG>CCT	p.P118P		NM_001001915	NP_001001915	Q8NGZ5	OR2G2_HUMAN	olfactory receptor, family 2, subfamily G,	118	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.017)			GCGTCCTCCCGGCTGTGATGT	0.522			NA											36	274					2.75727e-19	4.22277e-19	0.004878	1	0
OR2G2	81470	broad.mit.edu	37	1	247752598	247752598	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr1:247752598G>C	uc010pyy.1	+	1	937	c.937G>C	c.(937-939)GGA>CGA	p.G313R		NM_001001915	NP_001001915	Q8NGZ5	OR2G2_HUMAN	olfactory receptor, family 2, subfamily G,	313	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.017)			AAAGGCTCTGGGAGtaaatat	0.313			NA											33	118					0	0	0.00874	0	0
OR1C1	26188	broad.mit.edu	37	1	247921241	247921241	+	Silent	SNP	G	G	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr1:247921241G>T	uc010pza.1	-	1	468	c.468C>A	c.(466-468)GCC>GCA	p.A156A		NM_012353	NP_036485	Q15619	OR1C1_HUMAN	olfactory receptor, family 1, subfamily C,	156	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	all_cancers(71;4.34e-05)|all_epithelial(71;1.13e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0786)|Lung NSC(105;0.0858)	all_cancers(173;0.0247)	OV - Ovarian serous cystadenocarcinoma(106;0.0168)			TATGCAGGAGGGCGTGGAGGT	0.502			NA											7	50					2.7689e-08	3.53762e-08	0.001984	1	0
OR11L1	391189	broad.mit.edu	37	1	248004340	248004340	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr1:248004340G>T	uc001idn.1	-	1	859	c.859C>A	c.(859-861)CCA>ACA	p.P287T		NM_001001959	NP_001001959	Q8NGX0	O11L1_HUMAN	olfactory receptor, family 11, subfamily L,	287	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|pancreas(1)|skin(1)	3	all_cancers(71;8.78e-05)|all_epithelial(71;9.15e-06)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.0786)|Lung NSC(105;0.0858)		OV - Ovarian serous cystadenocarcinoma(106;0.0319)			TAGATAACTGGGTTCAGCAGT	0.428			NA											7	121					3.09899e-07	3.79566e-07	0.004482	1	0
OR2AK2	391191	broad.mit.edu	37	1	248129413	248129413	+	Silent	SNP	G	G	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr1:248129413G>A	uc010pzd.1	+	1	780	c.780G>A	c.(778-780)CTG>CTA	p.L260L	OR2L13_uc001ids.2_Intron	NM_001004491	NP_001004491	Q8NG84	O2AK2_HUMAN	olfactory receptor, family 2, subfamily AK,	260	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|breast(1)	2	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0152)			CCTCCCACCTGATTGTGGCAA	0.493	Melanoma(45;390 1181 23848 28461 41504)		NA											37	58					0	0	0.004289	0	0
OR2AK2	391191	broad.mit.edu	37	1	248129470	248129470	+	Silent	SNP	C	C	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr1:248129470C>T	uc010pzd.1	+	1	837	c.837C>T	c.(835-837)TCC>TCT	p.S279S	OR2L13_uc001ids.2_Intron	NM_001004491	NP_001004491	Q8NG84	O2AK2_HUMAN	olfactory receptor, family 2, subfamily AK,	279	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|breast(1)	2	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0152)			GGCCACACTCCTTGCGTTCCC	0.478	Melanoma(45;390 1181 23848 28461 41504)		NA											43	69					0	0	0.002852	0	0
OR2L1P	26247	broad.mit.edu	37	1	248153924	248153924	+	Missense_Mutation	SNP	T	T	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr1:248153924T>A	uc001idv.1	+	1	356	c.112T>A	c.(112-114)TAT>AAT	p.Y38N	OR2L13_uc001ids.2_Intron	NR_002145				RecName: Full=Olfactory receptor 2L5; AltName: Full=Olfactory receptor OR1-53;												0						ATCAATGGCCTATGATCGTTA	0.458			NA											6	177					0	0	0.001984	0	0
OR2L3	391192	broad.mit.edu	37	1	248224139	248224139	+	Silent	SNP	C	C	T	rs113796306		TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr1:248224139C>T	uc001idx.1	+	1	156	c.156C>T	c.(154-156)ACC>ACT	p.T52T	OR2L13_uc001ids.2_Intron	NM_001004687	NP_001004687	Q8NG85	OR2L3_HUMAN	olfactory receptor, family 2, subfamily L,	52	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0278)			TCTTGGACACCCATCTCCACA	0.403			NA											44	704					0	0	0.00361	0	0
OR2L3	391192	broad.mit.edu	37	1	248224332	248224332	+	Missense_Mutation	SNP	A	A	G			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr1:248224332A>G	uc001idx.1	+	1	349	c.349A>G	c.(349-351)ATG>GTG	p.M117V	OR2L13_uc001ids.2_Intron	NM_001004687	NP_001004687	Q8NG85	OR2L3_HUMAN	olfactory receptor, family 2, subfamily L,	117	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0278)			TTTGGCATCTATGGCCTATGA	0.438			NA											6	410					0	0	0.001984	0	0
OR2L13	284521	broad.mit.edu	37	1	248263030	248263031	+	Missense_Mutation	DNP	CC	CC	AA			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr1:248263030_248263031CC>AA	uc001ids.2	+	3	690_691	c.353_354CC>AA	c.(352-354)GCC>GAA	p.A118E		NM_175911	NP_787107	Q8N349	OR2LD_HUMAN	olfactory receptor, family 2, subfamily L,	118	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity|protein binding			central_nervous_system(2)|ovary(1)|skin(1)	4	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0132)			ACCTCCATGGCCTACGACCGTT	0.51			NA											38	275					0	0	0.004672	0	0
OR2M5	127059	broad.mit.edu	37	1	248308564	248308564	+	Missense_Mutation	SNP	T	T	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr1:248308564T>A	uc010pze.1	+	1	115	c.115T>A	c.(115-117)TTC>ATC	p.F39I		NM_001004690	NP_001004690	A3KFT3	OR2M5_HUMAN	olfactory receptor, family 2, subfamily M,	39	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|kidney(1)	3	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0388)			TTCAGTGGCCTTCATGGGAAA	0.517			NA											100	393					0	0	0.00361	0	0
OR2M4	26245	broad.mit.edu	37	1	248402946	248402946	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr1:248402946C>A	uc010pzh.1	+	1	716	c.716C>A	c.(715-717)ACT>AAT	p.T239N		NM_017504	NP_059974	Q96R27	OR2M4_HUMAN	olfactory receptor, family 2, subfamily M,	239	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)	2	all_cancers(71;0.000124)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			AAGGCCTTCACTACCTGCTCC	0.502			NA											17	86					2.35188e-11	3.29333e-11	0.006122	1	0
OR2T3	343173	broad.mit.edu	37	1	248637034	248637034	+	Missense_Mutation	SNP	A	A	G			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr1:248637034A>G	uc001iel.1	+	1	383	c.383A>G	c.(382-384)TAT>TGT	p.Y128C		NM_001005495	NP_001005495	Q8NH03	OR2T3_HUMAN	olfactory receptor, family 2, subfamily T,	128	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			TATGACCGATATGCTGCTGTT	0.552			NA											11	81					0	0	0.010504	0	0
CALML3	810	broad.mit.edu	37	10	5566982	5566983	+	Translation_Start_Site	DNP	CG	CG	AT			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	CG	CG	-	-	CG	CG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr10:5566982_5566983CG>AT	uc001iie.1	+	1	59_60	c.-66_-65CG>AT	c.(-68--63)GCCGGG>GCATGG		uc001iid.1_5'Flank	NM_005185	NP_005176	P27482	CALL3_HUMAN	calmodulin-like 3								calcium ion binding				0						GGACAGCAGCCGGGCTGCGGCA	0.688	Colon(173;2070 2647 27580 52203)		NA											4	9					0	0	0.004672	0	0
FAM171A1	221061	broad.mit.edu	37	10	15296879	15296879	+	Splice_Site	SNP	C	C	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr10:15296879C>A	uc001iob.2	-	4	426	c.419_splice	c.e4-1	p.G140_splice		NM_001010924	NP_001010924	Q5VUB5	F1711_HUMAN	hypothetical protein LOC221061 precursor							integral to membrane				ovary(2)|breast(1)|skin(1)	4						GGCCGGGCACCTGCAGAGATT	0.552			NA											8	45					1.06961e-07	1.33245e-07	0.00308	1	0
FAM188A	80013	broad.mit.edu	37	10	15821093	15821093	+	Silent	SNP	G	G	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr10:15821093G>A	uc001iod.1	-	15	1457	c.1236C>T	c.(1234-1236)CCC>CCT	p.P412P	FAM188A_uc001ioe.1_Silent_p.P239P	NM_024948	NP_079224	Q9H8M7	F188A_HUMAN	chromosome 10 open reading frame 97	412					apoptosis	nucleus	calcium ion binding			ovary(1)	1						TCTGTAGCATGGGATCTTCAA	0.428	Pancreas(159;946 1953 2111 4475 22008)		NA											14	40					0	0	0.00245	0	0
CUBN	8029	broad.mit.edu	37	10	16878336	16878337	+	Missense_Mutation	DNP	CC	CC	AA	rs147563157		TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr10:16878336_16878337CC>AA	uc001ioo.2	-	63	10129_10130	c.10077_10078GG>TT	c.(10075-10080)TCGGCT>TCTTCT	p.A3360S		NM_001081	NP_001072	O60494	CUBN_HUMAN	cubilin precursor	3360	CUB 25.				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			ovary(9)|breast(4)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|kidney(1)	19					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	ACTGGCACAGCCGAAGCATTTC	0.396			NA											10	97					0	0	0.004672	0	0
VIM	7431	broad.mit.edu	37	10	17275676	17275676	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr10:17275676G>A	uc001iou.2	+	4	1128	c.715G>A	c.(715-717)GAA>AAA	p.E239K	VIM_uc001iov.1_Missense_Mutation_p.E239K|VIM_uc001iow.1_RNA|VIM_uc001iox.1_Missense_Mutation_p.E239K|VIM_uc001ioy.1_Missense_Mutation_p.E239K|VIM_uc001ioz.1_RNA|VIM_uc001ipb.1_RNA|VIM_uc009xjv.1_Missense_Mutation_p.E239K|VIM_uc001ipc.1_Missense_Mutation_p.E239K	NM_003380	NP_003371	P08670	VIME_HUMAN	vimentin	239	Rod.|Coil 1B.				cellular component disassembly involved in apoptosis|cellular component movement|interspecies interaction between organisms|muscle filament sliding	cytosol|intermediate filament	protein C-terminus binding|structural constituent of cytoskeleton			large_intestine(1)|lung(1)|ovary(1)|pancreas(1)	4						GAAACTCCACGAAGAGGTTAG	0.473			NA											13	70					0	0	0.001368	0	0
ARMC3	219681	broad.mit.edu	37	10	23235133	23235134	+	Missense_Mutation	DNP	CC	CC	GA			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr10:23235133_23235134CC>GA	uc001irm.3	+	3	192_193	c.109_110CC>GA	c.(109-111)CCA>GAA	p.P37E	ARMC3_uc010qcv.1_Missense_Mutation_p.P37E|ARMC3_uc010qcw.1_Intron	NM_173081	NP_775104	Q5W041	ARMC3_HUMAN	armadillo repeat containing 3	37	ARM 1.						binding				0						GCTTAATTCTCCAGAAGAGGAA	0.317			NA											39	89					0	0	0.004672	0	0
GPR158	57512	broad.mit.edu	37	10	25887875	25887875	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr10:25887875C>A	uc001isj.2	+	11	3380	c.3320C>A	c.(3319-3321)CCT>CAT	p.P1107H	GPR158_uc001isk.2_Missense_Mutation_p.P482H	NM_020752	NP_065803	Q5T848	GP158_HUMAN	G protein-coupled receptor 158 precursor	1107	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(4)|large_intestine(2)|pancreas(1)|skin(1)	8						GGAGGTCAGCCTCGTGCAGCC	0.502			NA											22	147					7.41877e-09	9.6088e-09	0.001882	1	0
MPP7	143098	broad.mit.edu	37	10	28378646	28378646	+	Silent	SNP	C	C	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr10:28378646C>A	uc001iua.1	-	14	1481	c.1077G>T	c.(1075-1077)CCG>CCT	p.P359P	MPP7_uc009xkz.1_RNA|MPP7_uc001iub.1_Silent_p.P359P|MPP7_uc009xla.2_Silent_p.P359P|MPP7_uc010qdv.1_RNA	NM_173496	NP_775767	Q5T2T1	MPP7_HUMAN	palmitoylated membrane protein 7	359					establishment of cell polarity|positive regulation of protein complex assembly|protein localization to adherens junction|tight junction assembly	MPP7-DLG1-LIN7 complex|tight junction	protein complex scaffold|protein domain specific binding|protein heterodimerization activity|signaling adaptor activity			ovary(1)	1						GTCGCCGATACGGTGTCACTT	0.383			NA											5	288					1.024e-07	1.27899e-07	0.000602	1	0
SVIL	6840	broad.mit.edu	37	10	29782203	29782203	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr10:29782203G>A	uc001iut.1	-	21	4712	c.3959C>T	c.(3958-3960)CCA>CTA	p.P1320L	SVIL_uc010qdw.1_Missense_Mutation_p.P234L|SVIL_uc001iuu.1_Missense_Mutation_p.P894L|SVIL_uc009xlc.2_Missense_Mutation_p.P112L	NM_021738	NP_068506	O95425	SVIL_HUMAN	supervillin isoform 2	1320					cytoskeleton organization|skeletal muscle tissue development	cell junction|costamere|invadopodium|nucleus|podosome	actin filament binding			ovary(5)|upper_aerodigestive_tract(1)	6		Breast(68;0.103)				AGGACTTCTTGGCATATTATA	0.468			NA											15	47					0	0	0.003163	0	0
KIAA1462	57608	broad.mit.edu	37	10	30317933	30317933	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr10:30317933C>A	uc001iux.2	-	2	1203	c.1144G>T	c.(1144-1146)GCC>TCC	p.A382S	KIAA1462_uc001iuy.2_Intron|KIAA1462_uc001iuz.2_Missense_Mutation_p.A244S|KIAA1462_uc009xle.1_Missense_Mutation_p.A382S	NM_020848	NP_065899	Q9P266	K1462_HUMAN	hypothetical protein LOC57608	382	Pro-rich.									ovary(4)	4						TGACCGCTGGCCCCAGCCTTC	0.632			NA											54	119					7.77372e-23	1.23857e-22	0.00361	1	0
ZNF33A	7581	broad.mit.edu	37	10	38343873	38343873	+	Missense_Mutation	SNP	A	A	G			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr10:38343873A>G	uc001izh.2	+	5	996	c.818A>G	c.(817-819)CAC>CGC	p.H273R	ZNF33A_uc001izg.2_Missense_Mutation_p.H274R|ZNF33A_uc010qev.1_Missense_Mutation_p.H280R|ZNF33A_uc001izi.1_Intron	NM_006974	NP_008905	Q06730	ZN33A_HUMAN	zinc finger protein 33A isoform b	273						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)|skin(1)	3						AGGGACAATCACTATGAATTT	0.388			NA											32	71					0	0	0.002445	0	0
ZNF37A	7587	broad.mit.edu	37	10	38407520	38407520	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr10:38407520G>T	uc001izk.2	+	8	2260	c.1441G>T	c.(1441-1443)GCC>TCC	p.A481S	ZNF37A_uc001izl.2_Missense_Mutation_p.A481S|ZNF37A_uc001izm.2_Missense_Mutation_p.A481S	NM_001007094	NP_001007095	P17032	ZN37A_HUMAN	zinc finger protein 37a	481	C2H2-type 10.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)	1						TCAGAAGTCAGCCCTAATTGT	0.408			NA											17	96					8.60227e-14	1.24884e-13	0.004007	1	0
RET	5979	broad.mit.edu	37	10	43596063	43596063	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr10:43596063G>T	uc001jal.2	+	2	420	c.230G>T	c.(229-231)CGC>CTC	p.R77L	RET_uc001jak.1_Missense_Mutation_p.R77L	NM_020975	NP_066124	P07949	RET_HUMAN	ret proto-oncogene isoform a	77	Extracellular (Potential).		R -> C (in HSCR1).		homophilic cell adhesion|positive regulation of metanephric glomerulus development|positive regulation of transcription, DNA-dependent|posterior midgut development	integral to membrane	ATP binding|calcium ion binding|transmembrane receptor protein tyrosine kinase activity			thyroid(404)|adrenal_gland(20)|lung(9)|large_intestine(5)|breast(4)|ovary(4)|central_nervous_system(3)|urinary_tract(1)|NS(1)	451		Ovarian(717;0.0423)			Sunitinib(DB01268)	GGCACGTACCGCACACGGCTG	0.642	Melanoma(102;360 522 3376 9752 9881 14372 17251 18341 20876 24662 34807 43144 48149)		1	T|Mis|N|F	H4|PRKAR1A|NCOA4|PCM1|GOLGA5|TRIM33|KTN1|TRIM27|HOOK3	medullary thyroid| papillary thyroid|pheochromocytoma	medullary thyroid| papillary thyroid|pheochromocytoma	Hirschsprung disease		Multiple_Endocrine_Neoplasia_type_2B|Multiple_Endocrine_Neoplasia_type_2A|Familial_Medullary_Thyroid_Carcinoma				12	20					3.07112e-06	3.65297e-06	0.000978	1	0
PCDH15	65217	broad.mit.edu	37	10	55582700	55582700	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr10:55582700C>A	uc001jju.1	-	33	5181	c.4786G>T	c.(4786-4788)GAT>TAT	p.D1596Y	PCDH15_uc010qhq.1_Intron|PCDH15_uc010qhr.1_Intron|PCDH15_uc010qhs.1_Intron|PCDH15_uc010qht.1_Intron|PCDH15_uc010qhu.1_Intron|PCDH15_uc001jjv.1_Intron|PCDH15_uc010qhv.1_Missense_Mutation_p.D1593Y|PCDH15_uc010qhw.1_Missense_Mutation_p.D1556Y|PCDH15_uc010qhx.1_Missense_Mutation_p.D1527Y|PCDH15_uc010qhy.1_Missense_Mutation_p.D1603Y|PCDH15_uc010qhz.1_Missense_Mutation_p.D1598Y|PCDH15_uc010qia.1_Missense_Mutation_p.D1576Y|PCDH15_uc010qib.1_Missense_Mutation_p.D1573Y	NM_033056	NP_149045	Q96QU1	PCD15_HUMAN	protocadherin 15 isoform CD1-4 precursor	1596	Cytoplasmic (Potential).				equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			pancreas(5)|ovary(4)|upper_aerodigestive_tract(2)|skin(2)	13		Melanoma(3;0.117)|Lung SC(717;0.238)				TGCTGCAGATCTATGATCTCT	0.468			NA								HNSCC(58;0.16)			7	246					8.12818e-05	9.27259e-05	0.001984	1	0
PCDH15	65217	broad.mit.edu	37	10	56077052	56077052	+	Silent	SNP	G	G	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr10:56077052G>A	uc001jju.1	-	8	1250	c.855C>T	c.(853-855)GCC>GCT	p.A285A	PCDH15_uc010qhq.1_Silent_p.A290A|PCDH15_uc010qhr.1_Silent_p.A285A|PCDH15_uc010qhs.1_Silent_p.A290A|PCDH15_uc010qht.1_Silent_p.A285A|PCDH15_uc010qhu.1_Silent_p.A285A|PCDH15_uc001jjv.1_Silent_p.A263A|PCDH15_uc010qhv.1_Silent_p.A285A|PCDH15_uc010qhw.1_Silent_p.A248A|PCDH15_uc010qhx.1_Silent_p.A285A|PCDH15_uc010qhy.1_Silent_p.A290A|PCDH15_uc010qhz.1_Silent_p.A285A|PCDH15_uc010qia.1_Silent_p.A263A|PCDH15_uc010qib.1_Silent_p.A263A|PCDH15_uc001jjw.2_Silent_p.A285A	NM_033056	NP_149045	Q96QU1	PCD15_HUMAN	protocadherin 15 isoform CD1-4 precursor	285	Cadherin 3.|Extracellular (Potential).				equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			pancreas(5)|ovary(4)|upper_aerodigestive_tract(2)|skin(2)	13		Melanoma(3;0.117)|Lung SC(717;0.238)				ACTCAGGTATGGCAGCTTGAT	0.413			NA								HNSCC(58;0.16)			18	76					0	0	0.008871	0	0
FAM13C	220965	broad.mit.edu	37	10	61011385	61011385	+	Silent	SNP	C	C	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr10:61011385C>T	uc001jkn.2	-	14	1718	c.1584G>A	c.(1582-1584)CTG>CTA	p.L528L	FAM13C_uc001jko.2_Silent_p.L430L|FAM13C_uc010qid.1_Silent_p.L444L|FAM13C_uc010qie.1_Silent_p.L445L|FAM13C_uc010qif.1_Silent_p.L550L	NM_198215	NP_937858	Q8NE31	FA13C_HUMAN	hypothetical protein LOC220965 isoform 1	528										ovary(2)	2						AGGCTTTCCGCAGTCTCTTCT	0.393			NA											62	207					0	0	0.00361	0	0
ANK3	288	broad.mit.edu	37	10	62038579	62038579	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr10:62038579C>A	uc001jky.2	-	4	559	c.367G>T	c.(367-369)GTA>TTA	p.V123L	ANK3_uc010qih.1_Missense_Mutation_p.V106L|ANK3_uc001jkz.3_Missense_Mutation_p.V117L|ANK3_uc001jlb.1_5'UTR	NM_020987	NP_066267	Q12955	ANK3_HUMAN	ankyrin 3 isoform 1	123	ANK 2.				establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			skin(9)|ovary(6)|pancreas(2)|central_nervous_system(2)	19						AAGACTTTTACCACCTCTGCT	0.388			NA											11	139					1.08611e-07	1.34768e-07	0.000978	1	0
RHOBTB1	9886	broad.mit.edu	37	10	62634766	62634766	+	Silent	SNP	G	G	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr10:62634766G>A	uc001jli.2	-	10	2199	c.1761C>T	c.(1759-1761)GCC>GCT	p.A587A	RHOBTB1_uc001jlh.2_Silent_p.A587A|RHOBTB1_uc001jlj.2_Silent_p.A587A|RHOBTB1_uc001jlk.2_Silent_p.A587A|RHOBTB1_uc009xpe.1_Silent_p.A525A|RHOBTB1_uc009xpd.2_Silent_p.A52A|RHOBTB1_uc001jll.2_Silent_p.A337A	NM_014836	NP_055651	O94844	RHBT1_HUMAN	Rho-related BTB domain containing 1	587					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|plasma membrane	GTP binding			upper_aerodigestive_tract(1)	1	Prostate(12;0.0112)					CGCCACTCGTGGCGGCTTTGG	0.512			NA											13	95					0	0	0.003163	0	0
CTNNA3	29119	broad.mit.edu	37	10	68526032	68526032	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr10:68526032C>A	uc009xpn.1	-	9	1394	c.1271G>T	c.(1270-1272)AGG>ATG	p.R424M	CTNNA3_uc001jmw.2_Missense_Mutation_p.R424M|CTNNA3_uc001jmx.3_Missense_Mutation_p.R424M	NM_001127384	NP_001120856	Q9UI47	CTNA3_HUMAN	catenin, alpha 3	424					cell-cell adhesion	actin cytoskeleton|cytoplasm|fascia adherens	cadherin binding|structural molecule activity			skin(3)|ovary(2)|pancreas(1)|lung(1)|central_nervous_system(1)	8						CTCTACAAGCCTGCTGGTGTG	0.408			NA											29	234					1.39806e-14	2.04846e-14	0.008361	1	0
C10orf27	219793	broad.mit.edu	37	10	72539460	72539460	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr10:72539460G>A	uc001jrj.1	-	5	706	c.316C>T	c.(316-318)CCA>TCA	p.P106S	C10orf27_uc010qjm.1_Missense_Mutation_p.P106S|C10orf27_uc009xqh.1_RNA|C10orf27_uc010qjn.1_Missense_Mutation_p.P106S|C10orf27_uc009xqi.1_Intron|C10orf27_uc010qjo.1_Missense_Mutation_p.P95S|C10orf27_uc009xqj.1_Silent_p.F100F|C10orf27_uc010qjp.1_Missense_Mutation_p.P95S	NM_152710	NP_689923	Q96M53	SPATL_HUMAN	stromal protein associated with thymii and lymph	106					cell differentiation|multicellular organismal development|spermatogenesis	cytosol				skin(1)	1						AAGGGGGCTGGAAAATCCCTG	0.562			NA											7	80					0	0	0.004482	0	0
CDH23	64072	broad.mit.edu	37	10	73269950	73269950	+	Missense_Mutation	SNP	T	T	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr10:73269950T>A	uc001jrx.3	+	4	634	c.257T>A	c.(256-258)GTG>GAG	p.V86E	CDH23_uc001jrw.3_Missense_Mutation_p.V86E|CDH23_uc001jrv.2_Missense_Mutation_p.V81E|CDH23_uc009xql.2_Missense_Mutation_p.V131E	NM_022124	NP_071407	Q9H251	CAD23_HUMAN	cadherin-like 23 isoform 1 precursor	86	Cadherin 1.|Extracellular (Potential).				calcium ion transport|calcium-dependent cell-cell adhesion|cytosolic calcium ion homeostasis|equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	cytosol|integral to membrane|plasma membrane|stereocilium	calcium ion binding|protein binding			central_nervous_system(5)|large_intestine(4)|ovary(2)	11						GACACTGGCGTGGTGTGGCTC	0.617			NA											7	37					0	0	0.001882	0	0
DLG5	9231	broad.mit.edu	37	10	79571774	79571774	+	Silent	SNP	C	C	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr10:79571774C>T	uc001jzk.2	-	22	4300	c.4230G>A	c.(4228-4230)GCG>GCA	p.A1410A	DLG5_uc001jzi.2_Silent_p.A165A|DLG5_uc001jzj.2_Silent_p.A825A|DLG5_uc009xru.1_RNA	NM_004747	NP_004738	Q8TDM6	DLG5_HUMAN	discs large homolog 5	1410	PDZ 3.				cell-cell adhesion|intracellular signal transduction|negative regulation of cell proliferation|regulation of apoptosis	cell junction|cytoplasm	beta-catenin binding|cytoskeletal protein binding|receptor signaling complex scaffold activity			ovary(5)|breast(3)	8	all_cancers(46;0.0316)|all_epithelial(25;0.00147)|Breast(12;0.0015)|Prostate(51;0.0146)		Epithelial(14;0.00105)|OV - Ovarian serous cystadenocarcinoma(4;0.00151)|all cancers(16;0.00446)			TGATGAGCCGCGCCTGCTGCT	0.652			NA											12	100					0	0	0.00245	0	0
NRG3	10718	broad.mit.edu	37	10	84745279	84745279	+	Missense_Mutation	SNP	T	T	C			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr10:84745279T>C	uc001kco.2	+	9	2036	c.2009T>C	c.(2008-2010)CTG>CCG	p.L670P	NRG3_uc010qlz.1_Missense_Mutation_p.L669P|NRG3_uc001kcp.2_Missense_Mutation_p.L473P|NRG3_uc001kcq.2_Missense_Mutation_p.L320P|NRG3_uc001kcr.2_Missense_Mutation_p.L344P	NM_001010848	NP_001010848	P56975	NRG3_HUMAN	neuregulin 3 isoform 1	694	Cytoplasmic (Potential).				regulation of cell growth	extracellular region|integral to plasma membrane	growth factor activity|receptor tyrosine kinase binding|transmembrane receptor protein tyrosine kinase activator activity			lung(5)|breast(1)	6				GBM - Glioblastoma multiforme(1;2.5e-18)|all cancers(1;2.85e-09)		TTTCTCCCCCTGAGTCCCACA	0.478			NA											17	106					0	0	0.007413	0	0
PANK1	53354	broad.mit.edu	37	10	91371758	91371758	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr10:91371758C>A	uc001kgp.1	-	2	907	c.751G>T	c.(751-753)GTG>TTG	p.V251L	PANK1_uc001kgn.1_Missense_Mutation_p.V26L|PANK1_uc001kgo.1_Missense_Mutation_p.V26L|PANK1_uc009xtu.1_Missense_Mutation_p.V53L	NM_148977	NP_683878	Q8TE04	PANK1_HUMAN	pantothenate kinase 1 isoform alpha	251					coenzyme A biosynthetic process|pantothenate metabolic process	cytosol|nucleus	ATP binding|pantothenate kinase activity				0					Bezafibrate(DB01393)	TCGAAATACACCAATTTAACC	0.458			NA											14	104					3.45872e-05	4.00839e-05	0.004007	1	0
CYP2C9	1559	broad.mit.edu	37	10	96748684	96748684	+	Silent	SNP	C	C	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr10:96748684C>T	uc001kka.3	+	9	1397	c.1372C>T	c.(1372-1374)CTG>TTG	p.L458L	CYP2C9_uc009xut.2_Silent_p.L456L	NM_000771	NP_000762	P11712	CP2C9_HUMAN	cytochrome P450, family 2, subfamily C,	458					exogenous drug catabolic process|monocarboxylic acid metabolic process|monoterpenoid metabolic process|oxidative demethylation|steroid metabolic process|urea metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	(S)-limonene 6-monooxygenase activity|(S)-limonene 7-monooxygenase activity|4-hydroxyacetophenone monooxygenase activity|caffeine oxidase activity|drug binding|electron carrier activity|heme binding|oxygen binding|steroid hydroxylase activity			skin(4)|ovary(2)	6		Colorectal(252;0.0902)		all cancers(201;6.93e-05)	Acenocoumarol(DB01418)|Alosetron(DB00969)|Amiodarone(DB01118)|Antihemophilic Factor(DB00025)|Aprepitant(DB00673)|Bosentan(DB00559)|Carprofen(DB00821)|Carvedilol(DB01136)|Celecoxib(DB00482)|Clomipramine(DB01242)|Dapsone(DB00250)|Delavirdine(DB00705)|Desloratadine(DB00967)|Desogestrel(DB00304)|Diclofenac(DB00586)|Esomeprazole(DB00736)|Etodolac(DB00749)|Fluconazole(DB00196)|Fluoxetine(DB00472)|Flurbiprofen(DB00712)|Fluvastatin(DB01095)|Fluvoxamine(DB00176)|Formoterol(DB00983)|Gemfibrozil(DB01241)|Ginkgo biloba(DB01381)|Glibenclamide(DB01016)|Glimepiride(DB00222)|Glipizide(DB01067)|Guanfacine(DB01018)|Hydromorphone(DB00327)|Ibuprofen(DB01050)|Imipramine(DB00458)|Irbesartan(DB01029)|Ketoconazole(DB01026)|Lansoprazole(DB00448)|Losartan(DB00678)|Lumiracoxib(DB01283)|Marinol(DB00470)|Mefenamic acid(DB00784)|Meloxicam(DB00814)|Mephenytoin(DB00532)|Metronidazole(DB00916)|Miconazole(DB01110)|Midazolam(DB00683)|Montelukast(DB00471)|Nateglinide(DB00731)|Nelfinavir(DB00220)|Nicardipine(DB00622)|Oxymorphone(DB01192)|Pantoprazole(DB00213)|Paramethadione(DB00617)|Phenprocoumon(DB00946)|Phenytoin(DB00252)|Pravastatin(DB00175)|Quinidine(DB00908)|Ritonavir(DB00503)|Rosiglitazone(DB00412)|Sertraline(DB01104)|Sildenafil(DB00203)|Sulfamethoxazole(DB01015)|Suprofen(DB00870)|Tamoxifen(DB00675)|Tenoxicam(DB00469)|Terfenadine(DB00342)|Tolbutamide(DB01124)|Torasemide(DB00214)|Troleandomycin(DB01361)|Valdecoxib(DB00580)|Valsartan(DB00177)|Voriconazole(DB00582)|Warfarin(DB00682)|Zafirlukast(DB00549)|Zileuton(DB00744)	GAACTTTAACCTGAAATCTCT	0.473	Ovarian(54;1266 1406 16072 35076)		NA											29	216					0	0	0.008361	0	0
OBFC1	79991	broad.mit.edu	37	10	105659884	105659884	+	Silent	SNP	C	C	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr10:105659884C>T	uc001kxl.2	-	4	468	c.393G>A	c.(391-393)ACG>ACA	p.T131T	OBFC1_uc001kxm.2_Silent_p.T131T|OBFC1_uc001kxn.2_RNA	NM_024928	NP_079204	Q9H668	STN1_HUMAN	oligonucleotide/oligosaccharide-binding fold	131	OB.				positive regulation of DNA replication|telomere maintenance via telomere lengthening		protein binding|single-stranded telomeric DNA binding			ovary(1)	1		Colorectal(252;0.178)		Epithelial(162;3.39e-10)|all cancers(201;1.32e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0151)		TGACTCGGATCGTGTCCCCGA	0.458			NA											6	153					0	0	0.001984	0	0
SLK	9748	broad.mit.edu	37	10	105763286	105763286	+	Splice_Site	SNP	G	G	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr10:105763286G>A	uc001kxo.1	+	9	2383	c.2349_splice	c.e9+1	p.Q783_splice	SLK_uc001kxp.1_Splice_Site_p.Q783_splice	NM_014720	NP_055535	Q9H2G2	SLK_HUMAN	serine/threonine kinase 2						apoptosis|nucleotide-excision repair	cytoplasm|plasma membrane	ATP binding|DNA binding|nuclease activity|protein serine/threonine kinase activity			ovary(2)|stomach(2)|skin(2)|lung(1)|kidney(1)	8		Colorectal(252;0.178)		Epithelial(162;5.81e-10)|all cancers(201;2.35e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0165)		ATCTTTACAAGTAAGTGTACA	0.333	NSCLC(111;540 1651 1927 4474 17706)		NA											14	123					0	0	0.003163	0	0
TDRD1	56165	broad.mit.edu	37	10	115977387	115977387	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr10:115977387G>A	uc001lbg.1	+	17	2449	c.2296G>A	c.(2296-2298)GGA>AGA	p.G766R	TDRD1_uc001lbf.2_Missense_Mutation_p.G700R|TDRD1_uc001lbh.1_Missense_Mutation_p.G757R|TDRD1_uc001lbi.1_Missense_Mutation_p.G757R|TDRD1_uc010qsc.1_Missense_Mutation_p.G370R|TDRD1_uc001lbj.2_Missense_Mutation_p.G475R	NM_198795	NP_942090	Q9BXT4	TDRD1_HUMAN	tudor domain containing 1	766	Tudor 3.				DNA methylation involved in gamete generation|gene silencing by RNA|germ cell development|meiosis|multicellular organismal development|piRNA metabolic process|spermatogenesis	pi-body	nucleic acid binding|protein binding|zinc ion binding				0		Colorectal(252;0.172)|Breast(234;0.188)		Epithelial(162;0.0343)|all cancers(201;0.0754)		GGCAGAGATAGGACAACCTTG	0.348			NA											14	38					0	0	0.003163	0	0
PNLIPRP3	119548	broad.mit.edu	37	10	118215342	118215342	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr10:118215342G>T	uc001lcl.3	+	5	666	c.565G>T	c.(565-567)GGG>TGG	p.G189W		NM_001011709	NP_001011709	Q17RR3	LIPR3_HUMAN	pancreatic lipase-related protein 3 precursor	189					lipid catabolic process	extracellular region	triglyceride lipase activity			ovary(1)	1				all cancers(201;0.0131)		AAGAATAACTGGTAAGCATGC	0.448			NA											11	44					0.000673444	0.000742355	0.008291	1	0
PNLIP	5406	broad.mit.edu	37	10	118314780	118314780	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr10:118314780C>A	uc001lcm.2	+	7	705	c.662C>A	c.(661-663)ACG>AAG	p.T221K		NM_000936	NP_000927	P16233	LIPP_HUMAN	pancreatic lipase precursor	221					lipid catabolic process|retinoid metabolic process|steroid metabolic process	extracellular region	retinyl-palmitate esterase activity|triglyceride lipase activity			ovary(1)|central_nervous_system(1)|skin(1)	3				all cancers(201;0.0131)	Bentiromide(DB00522)|Orlistat(DB01083)	GTAATTCACACGGATGGTGCC	0.483			NA											11	96					1.08611e-07	1.34768e-07	0.000978	1	0
PNLIP	5406	broad.mit.edu	37	10	118318690	118318690	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr10:118318690G>A	uc001lcm.2	+	10	998	c.955G>A	c.(955-957)GGA>AGA	p.G319R		NM_000936	NP_000927	P16233	LIPP_HUMAN	pancreatic lipase precursor	319					lipid catabolic process|retinoid metabolic process|steroid metabolic process	extracellular region	retinyl-palmitate esterase activity|triglyceride lipase activity			ovary(1)|central_nervous_system(1)|skin(1)	3				all cancers(201;0.0131)	Bentiromide(DB00522)|Orlistat(DB01083)	TTGTCCAAGTGGAGGCTGCCC	0.413			NA											13	56					0	0	0.006122	0	0
PNLIPRP1	5407	broad.mit.edu	37	10	118350659	118350659	+	Silent	SNP	A	A	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr10:118350659A>T	uc001lco.1	+	2	36	c.18A>T	c.(16-18)ACA>ACT	p.T6T	PNLIPRP1_uc001lcp.2_Silent_p.T6T|PNLIPRP1_uc001lcn.2_Silent_p.T6T|PNLIPRP1_uc009xys.1_RNA	NM_006229	NP_006220	P54315	LIPR1_HUMAN	pancreatic lipase-related protein 1 precursor	6					lipid metabolic process		calcium ion binding|triglyceride lipase activity			ovary(1)|breast(1)	2				all cancers(201;0.0161)		TCTTCTGGACAATCACACTTT	0.493			NA											8	55					0	0	0.006214	0	0
PNLIPRP2	5408	broad.mit.edu	37	10	118383456	118383456	+	Splice_Site	SNP	G	G	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr10:118383456G>T	uc001lcq.2	+	3	76	c.53_splice	c.e3-1	p.G18_splice	PNLIPRP2_uc009xyu.1_Splice_Site|PNLIPRP2_uc009xyv.1_Splice_Site	NM_005396	NP_005387	P54317	LIPR2_HUMAN	pancreatic lipase-related protein 2						galactolipid catabolic process|lipid digestion|phospholipid catabolic process|triglyceride metabolic process	extracellular space	acylglycerol lipase activity|calcium ion binding|galactolipase activity|phospholipase activity|triglyceride lipase activity			large_intestine(1)	1				all cancers(201;0.015)		GCTCACCCTAGGAAAAGAGTC	0.493			NA											15	49					2.32078e-09	3.06421e-09	0.003163	1	0
SLC18A2	6571	broad.mit.edu	37	10	119027241	119027241	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr10:119027241G>C	uc001ldd.1	+	13	1211	c.1180G>C	c.(1180-1182)GCA>CCA	p.A394P	SLC18A2_uc009xyy.1_Missense_Mutation_p.A191P	NM_003054	NP_003045	Q05940	VMAT2_HUMAN	solute carrier family 18 (vesicular monoamine),	394	Helical; (Potential).				neurotransmitter secretion	clathrin sculpted monoamine transport vesicle membrane|integral to plasma membrane|membrane fraction	monoamine transmembrane transporter activity				0		Colorectal(252;0.19)		all cancers(201;0.029)	Alseroxylon(DB00386)|Reserpine(DB00206)|Tetrabenazine(DB04844)	AGTTGGTTTTGCAATTGGTAA	0.383			NA											3	44					0	0	0.000602	0	0
INPP5F	22876	broad.mit.edu	37	10	121571426	121571426	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr10:121571426G>T	uc001leo.2	+	15	2011	c.1845G>T	c.(1843-1845)GAG>GAT	p.E615D		NM_014937	NP_055752	Q9Y2H2	SAC2_HUMAN	inositol polyphosphate-5-phosphatase F	615							phosphoric ester hydrolase activity			ovary(2)	2		Lung NSC(174;0.109)|all_lung(145;0.142)		all cancers(201;0.00205)|BRCA - Breast invasive adenocarcinoma(275;0.158)		CTGATGATGAGAAGTTCCATG	0.463			NA											21	121					1.96292e-10	2.68909e-10	0.010504	1	0
NPS	594857	broad.mit.edu	37	10	129350781	129350781	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr10:129350781G>C	uc001ljx.1	+	3	168	c.148G>C	c.(148-150)GAC>CAC	p.D50H		NM_001030013	NP_001025184	P0C0P6	NPS_HUMAN	neuropeptide S precursor	50					neuropeptide signaling pathway	extracellular region					0						AACCAGATTGGACAGGAGCAA	0.428			NA											15	608					0	0	0.007413	0	0
B4GALNT4	338707	broad.mit.edu	37	11	373108	373108	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr11:373108C>A	uc001lpb.2	+	5	536	c.527C>A	c.(526-528)GCG>GAG	p.A176E		NM_178537	NP_848632	Q76KP1	B4GN4_HUMAN	beta	176	Lumenal (Potential).					Golgi cisterna membrane|integral to membrane	N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity			pancreas(1)	1		all_cancers(49;1.59e-06)|all_epithelial(84;0.000256)|Breast(177;0.00122)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;1.56e-27)|Epithelial(43;9.31e-27)|OV - Ovarian serous cystadenocarcinoma(40;1.11e-20)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0182)|LUSC - Lung squamous cell carcinoma(625;0.0703)		ATCCACCCGGCGAGGGACGGT	0.627			NA											30	74					1.39806e-14	2.04846e-14	0.008361	1	0
MUC2	4583	broad.mit.edu	37	11	1101128	1101128	+	Silent	SNP	G	G	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr11:1101128G>T	uc001lsx.1	+	44	14640	c.14613G>T	c.(14611-14613)ACG>ACT	p.T4871T		NM_002457	NP_002448	Q02817	MUC2_HUMAN	mucin 2 precursor	4871	VWFC 1.					inner mucus layer|outer mucus layer	protein binding			lung(1)|breast(1)	2		all_cancers(49;1.08e-07)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.191)		BRCA - Breast invasive adenocarcinoma(625;0.000207)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)	Pranlukast(DB01411)	ACCTCGCCACGGAGGTCAACC	0.622			NA											12	62					2.68362e-12	3.79146e-12	0.001368	1	0
OR51F1	256892	broad.mit.edu	37	11	4790262	4790262	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr11:4790262C>A	uc010qyl.1	-	1	886	c.886G>T	c.(886-888)GTA>TTA	p.V296L		NM_001004752	NP_001004752	A6NLW9	A6NLW9_HUMAN	olfactory receptor, family 51, subfamily F,	296						integral to membrane	olfactory receptor activity			ovary(1)|skin(1)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.0778)		Epithelial(150;5.87e-12)|BRCA - Breast invasive adenocarcinoma(625;0.0045)|LUSC - Lung squamous cell carcinoma(625;0.192)		TTTGTTTTTACACTGTCGATG	0.448			NA											34	70					4.44401e-20	6.86144e-20	0.002522	1	0
OR51B2	79345	broad.mit.edu	37	11	5345488	5345488	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr11:5345488C>G	uc001mao.1	-	1	95	c.40G>C	c.(40-42)GGC>CGC	p.G14R	HBG2_uc001mak.1_Intron|HBE1_uc001mam.1_Intron	NM_033180	NP_149420	Q9Y5P1	O51B2_HUMAN	olfactory receptor, family 51, subfamily B,	14	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;2.9e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CCTGGAAAGCCAGTCAGCAAA	0.488			NA									OREG0003719	type=REGULATORY REGION|Gene=OR51B2|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	7	52					0	0	0.00308	0	0
OR52B6	340980	broad.mit.edu	37	11	5602329	5602329	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr11:5602329C>A	uc010qzi.1	+	1	223	c.223C>A	c.(223-225)CTG>ATG	p.L75M	HBG2_uc001mak.1_Intron	NM_001005162	NP_001005162	Q8NGF0	O52B6_HUMAN	olfactory receptor, family 52, subfamily B,	75	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		Medulloblastoma(188;0.00225)|Breast(177;0.0204)|all_neural(188;0.0212)		Epithelial(150;3.56e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CCAGGCAATCCTGCATGAGCC	0.507			NA											50	92					9.52127e-25	1.53768e-24	0.00361	1	0
OR56A3	390083	broad.mit.edu	37	11	5968750	5968750	+	Silent	SNP	T	T	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr11:5968750T>A	uc010qzt.1	+	1	174	c.174T>A	c.(172-174)TCT>TCA	p.S58S		NM_001003443	NP_001003443	Q8NH54	O56A3_HUMAN	olfactory receptor, family 56, subfamily A,	58	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;9.41e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TGGAGGCCTCTCTGCACCAGC	0.617			NA											5	138					0	0	0.001168	0	0
OR10A2	341276	broad.mit.edu	37	11	6891892	6891892	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr11:6891892C>A	uc001meu.1	+	1	907	c.907C>A	c.(907-909)CCA>ACA	p.P303T		NM_001004460	NP_001004460	Q9H208	O10A2_HUMAN	olfactory receptor, family 10, subfamily A,	303					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)	1		Medulloblastoma(188;0.0523)|all_neural(188;0.236)		Epithelial(150;4.89e-08)|BRCA - Breast invasive adenocarcinoma(625;0.13)		AAACTGTATCCCATAGACCTT	0.453			NA											47	103					3.54909e-21	5.56122e-21	0.002852	1	0
NLRP14	338323	broad.mit.edu	37	11	7064041	7064041	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr11:7064041G>A	uc001mfb.1	+	4	1107	c.784G>A	c.(784-786)GAT>AAT	p.D262N		NM_176822	NP_789792	Q86W24	NAL14_HUMAN	NLR family, pyrin domain containing 14	262	NACHT.				cell differentiation|multicellular organismal development|spermatogenesis		ATP binding			ovary(3)|breast(2)|pancreas(1)|lung(1)|skin(1)	8				Epithelial(150;4.62e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0871)		TGACAGTTTCGATGAACTGAA	0.453			NA											42	138					0	0	0.00874	0	0
NLRP14	338323	broad.mit.edu	37	11	7079669	7079669	+	Missense_Mutation	SNP	T	T	G			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr11:7079669T>G	uc001mfb.1	+	8	2944	c.2621T>G	c.(2620-2622)CTG>CGG	p.L874R		NM_176822	NP_789792	Q86W24	NAL14_HUMAN	NLR family, pyrin domain containing 14	874	LRR 6.				cell differentiation|multicellular organismal development|spermatogenesis		ATP binding			ovary(3)|breast(2)|pancreas(1)|lung(1)|skin(1)	8				Epithelial(150;4.62e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0871)		CAATGTACTCTGAAGAGCCTT	0.343			NA											6	158					0	0	0.004482	0	0
ANO3	63982	broad.mit.edu	37	11	26538397	26538397	+	Silent	SNP	C	C	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr11:26538397C>T	uc001mqt.3	+	6	760	c.615C>T	c.(613-615)ATC>ATT	p.I205I	ANO3_uc010rdr.1_Silent_p.I189I|ANO3_uc010rds.1_Silent_p.I59I|ANO3_uc010rdt.1_Silent_p.I59I	NM_031418	NP_113606	Q9BYT9	ANO3_HUMAN	transmembrane protein 16C	205	Cytoplasmic (Potential).					chloride channel complex	chloride channel activity			ovary(2)|central_nervous_system(1)|pancreas(1)	4						GCCCCGATATCATGTTTATTA	0.383			NA											4	28					0	0	0.009096	0	0
KCNA4	3739	broad.mit.edu	37	11	30034035	30034035	+	Missense_Mutation	SNP	T	T	C			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr11:30034035T>C	uc001msk.2	-	2	1343	c.191A>G	c.(190-192)CAC>CGC	p.H64R		NM_002233	NP_002224	P22459	KCNA4_HUMAN	potassium voltage-gated channel, shaker-related	64	Poly-His.					voltage-gated potassium channel complex	potassium ion binding|protein binding|voltage-gated potassium channel activity			ovary(2)|central_nervous_system(1)|pancreas(1)	4						TGACTGGTGGTGGTGGTGGGA	0.652			NA											6	25					0	0	0.001855	0	0
QSER1	79832	broad.mit.edu	37	11	32953814	32953814	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr11:32953814C>T	uc001mty.2	+	4	890	c.623C>T	c.(622-624)TCA>TTA	p.S208L	QSER1_uc001mtz.1_Missense_Mutation_p.S208L|QSER1_uc001mua.2_5'Flank	NM_001076786	NP_001070254	Q2KHR3	QSER1_HUMAN	glutamine and serine rich 1	208	Ser-rich.									ovary(3)|central_nervous_system(2)|skin(1)	6	Breast(20;0.158)					CTGACTGGTTCACAGCACTCC	0.418			NA											5	120					0	0	0.000602	0	0
RAG1	5896	broad.mit.edu	37	11	36596535	36596535	+	Missense_Mutation	SNP	C	C	T	rs104894285		TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr11:36596535C>T	uc001mwu.3	+	2	1805	c.1681C>T	c.(1681-1683)CGC>TGC	p.R561C	RAG1_uc001mwt.2_RNA	NM_000448	NP_000439	P15918	RAG1_HUMAN	recombination activating gene 1	561			R -> C (in OS).|R -> H (in OS).		histone monoubiquitination|immune response|pre-B cell allelic exclusion|protein autoubiquitination|T cell differentiation in thymus|V(D)J recombination	nucleus	endonuclease activity|histone binding|protein homodimerization activity|sequence-specific DNA binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|pancreas(1)|lung(1)|kidney(1)|skin(1)	5	all_lung(20;0.226)	all_hematologic(20;0.107)				AAAGAGGTTCCGCTATGATTC	0.468	Pancreas(43;321 1249 3212 48200)|Esophageal Squamous(38;49 1003 17530 24363)		NA							Familial_Hemophagocytic_Lymphohistiocytosis				4	81					0	0	0.000602	0	0
RAG1	5896	broad.mit.edu	37	11	36596940	36596940	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr11:36596940G>T	uc001mwu.3	+	2	2210	c.2086G>T	c.(2086-2088)GGC>TGC	p.G696C	RAG1_uc001mwt.2_RNA	NM_000448	NP_000439	P15918	RAG1_HUMAN	recombination activating gene 1	696					histone monoubiquitination|immune response|pre-B cell allelic exclusion|protein autoubiquitination|T cell differentiation in thymus|V(D)J recombination	nucleus	endonuclease activity|histone binding|protein homodimerization activity|sequence-specific DNA binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|pancreas(1)|lung(1)|kidney(1)|skin(1)	5	all_lung(20;0.226)	all_hematologic(20;0.107)				TGAGCTGGGAGGCATTCTCCG	0.532	Pancreas(43;321 1249 3212 48200)|Esophageal Squamous(38;49 1003 17530 24363)		NA							Familial_Hemophagocytic_Lymphohistiocytosis				28	62					1.68575e-08	2.16544e-08	0.007291	1	0
TTC17	55761	broad.mit.edu	37	11	43427092	43427092	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr11:43427092G>T	uc001mxi.2	+	12	1522	c.1508G>T	c.(1507-1509)AGA>ATA	p.R503I	TTC17_uc001mxh.2_Missense_Mutation_p.R503I|TTC17_uc010rfj.1_Missense_Mutation_p.R446I|TTC17_uc001mxj.2_Missense_Mutation_p.R273I	NM_018259	NP_060729	Q96AE7	TTC17_HUMAN	tetratricopeptide repeat domain 17	503							binding			ovary(5)	5						TGGCCTAAAAGAGCAGATTGT	0.368			NA											155	192					2.07621e-90	3.47133e-90	0.00361	1	0
ACCSL	390110	broad.mit.edu	37	11	44074297	44074297	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr11:44074297C>A	uc001mxw.1	+	6	914	c.858C>A	c.(856-858)CAC>CAA	p.H286Q	ACCSL_uc009ykr.2_Missense_Mutation_p.H105Q	NM_001031854	NP_001027025	Q4AC99	1A1L2_HUMAN	1-aminocyclopropane-1-carboxylate synthase	286							1-aminocyclopropane-1-carboxylate synthase activity|pyridoxal phosphate binding|transferase activity, transferring nitrogenous groups			ovary(5)	5						TTCCTGTCCACCTGGAGAGTG	0.542			NA											251	253					8.08517e-138	1.3542e-137	0.00361	1	0
MADD	8567	broad.mit.edu	37	11	47307001	47307001	+	Splice_Site	SNP	G	G	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr11:47307001G>T	uc001ner.1	+	14	2603	c.2412_splice	c.e14-1	p.R804_splice	MADD_uc001neq.2_Splice_Site_p.R804_splice|MADD_uc001nev.1_Splice_Site_p.G761_splice|MADD_uc001nes.1_Splice_Site_p.G761_splice|MADD_uc001net.1_Splice_Site_p.R804_splice|MADD_uc009yln.1_Splice_Site_p.G761_splice|MADD_uc001neu.1_Splice_Site_p.G761_splice|MADD_uc001nex.2_Splice_Site_p.R804_splice|MADD_uc001nez.2_Splice_Site_p.G761_splice|MADD_uc001new.2_Splice_Site_p.R804_splice	NM_003682	NP_003673	Q8WXG6	MADD_HUMAN	MAP-kinase activating death domain-containing						activation of MAPK activity|apoptosis|cell surface receptor linked signaling pathway|regulation of apoptosis|regulation of cell cycle	cytoplasm|integral to membrane|plasma membrane	death receptor binding|protein kinase activator activity|Rab guanyl-nucleotide exchange factor activity			ovary(5)|skin(4)|central_nervous_system(2)	11				Lung(87;0.182)		GTGCATTCAAGGGCTCAAAAG	0.547			NA											34	249					1.36161e-19	2.09208e-19	0.004289	1	0
OR4C3	256144	broad.mit.edu	37	11	48346719	48346719	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr11:48346719C>G	uc010rhv.1	+	1	227	c.227C>G	c.(226-228)TCC>TGC	p.S76C		NM_001004702	NP_001004702	Q8NH37	OR4C3_HUMAN	olfactory receptor, family 4, subfamily C,	49	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						ACTATCACCTCCAGCCCCACG	0.458			NA											6	250					0	0	0.001984	0	0
OR4A16	81327	broad.mit.edu	37	11	55111106	55111106	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr11:55111106G>T	uc010rie.1	+	1	430	c.430G>T	c.(430-432)GTG>TTG	p.V144L		NM_001005274	NP_001005274	Q8NH70	O4A16_HUMAN	olfactory receptor, family 4, subfamily A,	144	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(2)|pancreas(1)	3						CCTTCTGTTGGTGGTGGCCAT	0.463			NA											39	163					7.63091e-17	1.14464e-16	0.007835	1	0
OR5D14	219436	broad.mit.edu	37	11	55563765	55563765	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr11:55563765C>T	uc010rim.1	+	1	734	c.734C>T	c.(733-735)TCC>TTC	p.S245F		NM_001004735	NP_001004735	Q8NGL3	OR5DE_HUMAN	olfactory receptor, family 5, subfamily D,	245	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|central_nervous_system(1)	3		all_epithelial(135;0.196)				ACCTGGGCCTCCCACCTGACT	0.463			NA											19	126					0	0	0.00278	0	0
OR5L1	219437	broad.mit.edu	37	11	55579236	55579237	+	Missense_Mutation	DNP	GG	GG	AA			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr11:55579236_55579237GG>AA	uc001nhw.1	+	1	294_295	c.294_295GG>AA	c.(292-297)ATGGTG>ATAATG	p.98_99MV>IM		NM_001004738	NP_001004738	Q8NGL2	OR5L1_HUMAN	olfactory receptor, family 5, subfamily L,	98_99	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(3)|ovary(2)	5		all_epithelial(135;0.208)				TAGGGTGCATGGTGCAATTCTA	0.45			NA											9	322					0	0	0.004672	0	0
OR5D18	219438	broad.mit.edu	37	11	55587852	55587852	+	Silent	SNP	C	C	T	rs148575844		TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr11:55587852C>T	uc010rin.1	+	1	747	c.747C>T	c.(745-747)ATC>ATT	p.I249I		NM_001001952	NP_001001952	Q8NGL1	OR5DI_HUMAN	olfactory receptor, family 5, subfamily D,	249	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)	3		all_epithelial(135;0.208)				TGACTGCCATCACCATCTTCC	0.517			NA											24	88					0	0	0.002299	0	0
SPRYD5	84767	broad.mit.edu	37	11	55653024	55653024	+	Nonsense_Mutation	SNP	C	C	G			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr11:55653024C>G	uc010rip.1	+	2	212	c.120C>G	c.(118-120)TAC>TAG	p.Y40*	SPRYD5_uc010riq.1_5'Flank	NM_032681	NP_116070	Q9BSJ1	SPRY5_HUMAN	SPRY domain containing 5	40	RING-type.					intracellular	zinc ion binding				0		all_epithelial(135;0.226)				CCTGTTTGTACCTCAACTGGC	0.507			NA											5	71					0	0	0.000602	0	0
SPRYD5	84767	broad.mit.edu	37	11	55657475	55657475	+	Silent	SNP	G	G	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr11:55657475G>T	uc010rip.1	+	6	911	c.819G>T	c.(817-819)GGG>GGT	p.G273G	SPRYD5_uc010riq.1_Silent_p.G130G	NM_032681	NP_116070	Q9BSJ1	SPRY5_HUMAN	SPRY domain containing 5	273	B30.2/SPRY.					intracellular	zinc ion binding				0		all_epithelial(135;0.226)				TCAGTGCAGGGCCCATCACTG	0.498			NA											5	45					3.59834e-05	4.13983e-05	0.001168	1	0
OR8H3	390152	broad.mit.edu	37	11	55890117	55890117	+	Missense_Mutation	SNP	A	A	G			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr11:55890117A>G	uc001nii.1	+	1	269	c.269A>G	c.(268-270)AAC>AGC	p.N90S		NM_001005201	NP_001005201	Q8N146	OR8H3_HUMAN	olfactory receptor, family 8, subfamily H,	90	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	Esophageal squamous(21;0.00693)					CTGACTTCCAACTATATTTCC	0.423			NA											21	693					0	0	0.00278	0	0
OR5AR1	219493	broad.mit.edu	37	11	56431427	56431427	+	Missense_Mutation	SNP	A	A	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr11:56431427A>T	uc010rjm.1	+	1	266	c.266A>T	c.(265-267)CAC>CTC	p.H89L		NM_001004730	NP_001004730	Q8NGP9	O5AR1_HUMAN	olfactory receptor, family 5, subfamily AR,	89	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						CTAACAAATCACAAAGTTATC	0.498			NA											10	388					0	0	0.006214	0	0
OR10Q1	219960	broad.mit.edu	37	11	57996204	57996204	+	Silent	SNP	G	G	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr11:57996204G>T	uc010rkd.1	-	1	144	c.144C>A	c.(142-144)GCC>GCA	p.A48A		NM_001004471	NP_001004471	Q8NGQ4	O10Q1_HUMAN	olfactory receptor, family 10, subfamily Q,	48	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2		Breast(21;0.0589)				CCCAGATGATGGCTGTGTTGC	0.527			NA											18	114					2.4624e-09	3.24216e-09	0.008871	1	0
MS4A6A	64231	broad.mit.edu	37	11	59945759	59945759	+	Missense_Mutation	SNP	T	T	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr11:59945759T>A	uc001nor.2	-	4	551	c.313A>T	c.(313-315)ACA>TCA	p.T105S	MS4A6A_uc001noq.2_Missense_Mutation_p.T105S|MS4A6A_uc001nos.3_Missense_Mutation_p.T133S|MS4A6A_uc009ymv.2_Missense_Mutation_p.T105S|MS4A6A_uc001not.2_Missense_Mutation_p.T105S|MS4A6A_uc010rla.1_Missense_Mutation_p.T133S|MS4A6A_uc010rlb.1_Missense_Mutation_p.T60S	NM_152852	NP_690591	Q9H2W1	M4A6A_HUMAN	membrane-spanning 4-domains, subfamily A, member	105	Helical; (Potential).					integral to membrane	receptor activity				0						CTTTTCTCTGTGGCGATTGAT	0.393			NA											9	81					0	0	0.006214	0	0
TMEM132A	54972	broad.mit.edu	37	11	60703933	60703933	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr11:60703933C>G	uc001nqj.2	+	11	2819	c.2626C>G	c.(2626-2628)CAG>GAG	p.Q876E	TMEM132A_uc001nqi.2_Missense_Mutation_p.Q877E|TMEM132A_uc001nqm.2_Missense_Mutation_p.Q86E	NM_178031	NP_821174	Q24JP5	T132A_HUMAN	transmembrane protein 132A isoform b	876	Binds to HSPA5/GRP78 (By similarity).|Cytoplasmic (Potential).|Confers cellular localization similar to full-length form (By similarity).					endoplasmic reticulum membrane|Golgi membrane|integral to membrane				skin(1)	1						CCTGCGCTATCAGCGCAAAGA	0.607			NA											7	194					0	0	0.001984	0	0
C11orf84	144097	broad.mit.edu	37	11	63586320	63586320	+	Silent	SNP	C	C	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr11:63586320C>A	uc001nxt.2	+	5	1016	c.780C>A	c.(778-780)GCC>GCA	p.A260A		NM_138471	NP_612480	Q9BUA3	CK084_HUMAN	hypothetical protein LOC144097	260											0						CAGCACCAGCCGAGGTCCGAC	0.632			NA											35	54					1.15183e-24	1.85704e-24	0.009718	1	0
SLC22A11	55867	broad.mit.edu	37	11	64323733	64323733	+	Missense_Mutation	SNP	T	T	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr11:64323733T>A	uc001oai.2	+	1	636	c.262T>A	c.(262-264)TTC>ATC	p.F88I	SLC22A11_uc001oah.1_Missense_Mutation_p.F88I|SLC22A11_uc001oaj.2_Missense_Mutation_p.F88I|SLC22A11_uc009ypq.2_Missense_Mutation_p.F88I	NM_018484	NP_060954	Q9NSA0	S22AB_HUMAN	solute carrier family 22 member 11	88	Extracellular (Potential).				urate metabolic process	apical plasma membrane|external side of plasma membrane|integral to plasma membrane	inorganic anion exchanger activity|protein binding|sodium-independent organic anion transmembrane transporter activity			ovary(1)|central_nervous_system(1)	2					Probenecid(DB01032)	GTGCCGCCGCTTCCGCCAGCC	0.657			NA									OREG0004031	type=REGULATORY REGION|Gene=SLC22A11|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	9	47					0	0	0.001368	0	0
GAL3ST3	89792	broad.mit.edu	37	11	65810715	65810715	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr11:65810715G>T	uc001ogv.2	-	2	719	c.559C>A	c.(559-561)CCC>ACC	p.P187T	GAL3ST3_uc001ogw.2_Missense_Mutation_p.P187T	NM_033036	NP_149025	Q96A11	G3ST3_HUMAN	galactose-3-O-sulfotransferase 3	187	Lumenal (Potential).				monosaccharide metabolic process|oligosaccharide metabolic process|poly-N-acetyllactosamine metabolic process|proteoglycan biosynthetic process|sulfur compound metabolic process	Golgi cisterna membrane|integral to membrane	3'-phosphoadenosine 5'-phosphosulfate binding|carbohydrate binding|galactosylceramide sulfotransferase activity|proteoglycan sulfotransferase activity			ovary(1)	1						TATGCCTCGGGCGCGCGCAGG	0.677			NA											26	40					1.17739e-12	1.67845e-12	0.005443	1	0
BRMS1	25855	broad.mit.edu	37	11	66109713	66109713	+	Splice_Site	SNP	C	C	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr11:66109713C>T	uc001ohp.1	-	2	141	c.-6_splice	c.e2-1		BRMS1_uc001oho.1_Splice_Site|BRMS1_uc009yre.2_5'Flank	NM_015399	NP_056214	Q9HCU9	BRMS1_HUMAN	breast cancer metastasis suppressor 1 isoform 1						apoptosis|negative regulation of anti-apoptosis|negative regulation of NF-kappaB transcription factor activity|negative regulation of transcription, DNA-dependent|positive regulation of anoikis|positive regulation of protein deacetylation|transcription, DNA-dependent	cytoplasm|nucleus	NF-kappaB binding				0						CATCTGGACTCTGGGAGAAGG	0.542	GBM(7;55 307 2662 20856 28942)		NA											19	142					0	0	0.008871	0	0
RHOD	29984	broad.mit.edu	37	11	66837915	66837915	+	Missense_Mutation	SNP	A	A	G			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr11:66837915A>G	uc001ojv.2	+	4	435	c.350A>G	c.(349-351)CAT>CGT	p.H117R		NM_014578	NP_055393	O00212	RHOD_HUMAN	ras homolog D precursor	117					regulation of small GTPase mediated signal transduction|Rho protein signal transduction	cytosol|plasma membrane	GTP binding|GTPase activity				0						GAAGTGAATCATTTCTGCAAG	0.567			NA											32	56					0	0	0.003271	0	0
GPR152	390212	broad.mit.edu	37	11	67219375	67219375	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr11:67219375C>A	uc001olm.2	-	1	826	c.821G>T	c.(820-822)TGG>TTG	p.W274L	uc009yrw.1_5'Flank|CABP4_uc001oln.2_5'Flank	NM_206997	NP_996880	Q8TDT2	GP152_HUMAN	G protein-coupled receptor 152	274	Helical; Name=6; (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity				0			BRCA - Breast invasive adenocarcinoma(15;8.18e-06)			CAGGGCCTCCCAGAGCAGGTA	0.627	Pancreas(102;800 1581 2723 7382 33622)		NA											31	90					6.04164e-23	9.64222e-23	0.002096	1	0
SUV420H1	51111	broad.mit.edu	37	11	67925826	67925826	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr11:67925826C>A	uc001onm.1	-	11	2243	c.1987G>T	c.(1987-1989)GTG>TTG	p.V663L	SUV420H1_uc009yse.1_Missense_Mutation_p.V249L|SUV420H1_uc001onn.1_Missense_Mutation_p.V491L|SUV420H1_uc009ysf.2_Missense_Mutation_p.V423L	NM_017635	NP_060105	Q4FZB7	SV421_HUMAN	suppressor of variegation 4-20 homolog 1 isoform	663					regulation of transcription, DNA-dependent|transcription, DNA-dependent		protein binding			ovary(2)|kidney(1)	3						GTGTAGCTCACAGGCACGCCC	0.493			NA											7	100					0.00307968	0.00329147	0.00308	1	0
SUV420H1	51111	broad.mit.edu	37	11	67926156	67926156	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr11:67926156C>T	uc001onm.1	-	11	1913	c.1657G>A	c.(1657-1659)GAC>AAC	p.D553N	SUV420H1_uc009yse.1_Missense_Mutation_p.D139N|SUV420H1_uc001onn.1_Missense_Mutation_p.D381N|SUV420H1_uc009ysf.2_Missense_Mutation_p.D313N	NM_017635	NP_060105	Q4FZB7	SV421_HUMAN	suppressor of variegation 4-20 homolog 1 isoform	553					regulation of transcription, DNA-dependent|transcription, DNA-dependent		protein binding			ovary(2)|kidney(1)	3						AGCTTGATGTCAGAGGCCTCC	0.537			NA											7	355					0	0	0.004482	0	0
LRP5	4041	broad.mit.edu	37	11	68171004	68171004	+	Silent	SNP	G	G	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr11:68171004G>A	uc001ont.2	+	8	1713	c.1638G>A	c.(1636-1638)CCG>CCA	p.P546P	LRP5_uc009ysg.2_5'UTR	NM_002335	NP_002326	O75197	LRP5_HUMAN	low density lipoprotein receptor-related protein	546	LDL-receptor class B 9.|Beta-propeller 2.|Extracellular (Potential).				adipose tissue development|bone marrow development|bone morphogenesis|canonical Wnt receptor signaling pathway|cholesterol homeostasis|endocytosis|glucose catabolic process|negative regulation of osteoblast differentiation|negative regulation of protein serine/threonine kinase activity|positive regulation of fat cell differentiation|positive regulation of mesenchymal cell proliferation|positive regulation of mitosis|positive regulation of transcription from RNA polymerase II promoter|regulation of blood pressure|regulation of canonical Wnt receptor signaling pathway|retina morphogenesis in camera-type eye|retinal blood vessel morphogenesis|Wnt receptor signaling pathway involved in dorsal/ventral axis specification	endoplasmic reticulum|integral to membrane|plasma membrane|receptor complex	protein binding|receptor activity			lung(2)|skin(2)|ovary(1)|pancreas(1)|breast(1)	7						ACAAGCTCCCGCACATTTTTG	0.607			NA											12	90					0	0	0.001855	0	0
KRTAP5-11	440051	broad.mit.edu	37	11	71293440	71293440	+	Silent	SNP	G	G	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr11:71293440G>A	uc001oqu.2	-	1	482	c.444C>T	c.(442-444)GTC>GTT	p.V148V		NM_001005405	NP_001005405	Q6L8G4	KR511_HUMAN	keratin associated protein 5-11	148	6.|6 X 4 AA repeats of C-C-X-P.					keratin filament					0						AGCACACGGGGACAcagcagc	0.249			NA											8	78					0	0	0.001855	0	0
RELT	84957	broad.mit.edu	37	11	73103419	73103419	+	Silent	SNP	G	G	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr11:73103419G>T	uc001otv.2	+	6	696	c.531G>T	c.(529-531)CTG>CTT	p.L177L	RELT_uc001otw.2_Silent_p.L177L|RELT_uc009yto.1_Silent_p.L95L|RELT_uc001otx.2_5'Flank	NM_152222	NP_689408	Q969Z4	TR19L_HUMAN	RELT tumor necrosis factor receptor precursor	177	Helical; (Potential).					cytoplasm|integral to membrane|plasma membrane	binding|receptor activity			upper_aerodigestive_tract(1)	1						TCATGGGGCTGTTGGGCATCC	0.682			NA											19	60					8.10497e-08	1.01634e-07	0.010504	1	0
C11orf82	220042	broad.mit.edu	37	11	82625869	82625869	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr11:82625869C>G	uc001ozt.2	+	3	333	c.89C>G	c.(88-90)TCT>TGT	p.S30C	C11orf82_uc010rsr.1_5'UTR|C11orf82_uc010rss.1_5'UTR|C11orf82_uc009yvd.2_Missense_Mutation_p.S30C	NM_145018	NP_659455	Q8IXT1	NOXIN_HUMAN	nitric oxide-inducible gene protein	30					apoptosis|cell cycle arrest	cytoplasm|nucleus				ovary(2)	2						AAGTGCTTCTCTAGGATAATC	0.403			NA											26	110					0	0	0.00333	0	0
GRIA4	2893	broad.mit.edu	37	11	105781249	105781249	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr11:105781249C>A	uc001pix.2	+	10	1693	c.1247C>A	c.(1246-1248)ACA>AAA	p.T416K	GRIA4_uc001piu.1_Missense_Mutation_p.T416K|GRIA4_uc001piw.2_Missense_Mutation_p.T416K|GRIA4_uc009yxk.1_Missense_Mutation_p.T416K	NM_000829	NP_000820	P48058	GRIA4_HUMAN	glutamate receptor, ionotrophic, AMPA 4 isoform	416	Extracellular (Potential).				glutamate signaling pathway|synaptic transmission	cell junction|endocytic vesicle membrane|integral to membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity			ovary(3)|skin(3)|lung(1)|central_nervous_system(1)	8		Melanoma(852;0.000902)|Acute lymphoblastic leukemia(157;0.000994)|all_hematologic(158;0.0017)|Breast(348;0.0323)		BRCA - Breast invasive adenocarcinoma(274;0.000147)|Epithelial(105;0.0291)|all cancers(92;0.0899)	L-Glutamic Acid(DB00142)	GAGAACAGAACAGTGGTTGTA	0.423			NA											8	53					0.000274275	0.000305179	0.004482	1	0
KDELC2	143888	broad.mit.edu	37	11	108352829	108352829	+	Missense_Mutation	SNP	T	T	C			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr11:108352829T>C	uc001pkj.2	-	4	871	c.805A>G	c.(805-807)AGA>GGA	p.R269G	KDELC2_uc001pki.2_Missense_Mutation_p.R213G	NM_153705	NP_714916	Q7Z4H8	KDEL2_HUMAN	KDEL (Lys-Asp-Glu-Leu) containing 2 precursor	269						endoplasmic reticulum lumen				ovary(1)	1		all_cancers(61;1.38e-11)|all_epithelial(67;3.16e-07)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		Epithelial(105;6.93e-06)|BRCA - Breast invasive adenocarcinoma(274;8.54e-06)|all cancers(92;0.00016)|OV - Ovarian serous cystadenocarcinoma(223;0.132)|Colorectal(284;0.14)		ACAACATCTCTTGAATCCAGA	0.448			NA											11	196					0	0	0.001368	0	0
ZC3H12C	85463	broad.mit.edu	37	11	110023681	110023681	+	Nonsense_Mutation	SNP	A	A	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr11:110023681A>T	uc009yxw.2	+	3	862	c.811A>T	c.(811-813)AAA>TAA	p.K271*	ZC3H12C_uc010rwc.1_Nonsense_Mutation_p.K272*|ZC3H12C_uc010rwd.1_Nonsense_Mutation_p.K272*|ZC3H12C_uc001pkr.3_Nonsense_Mutation_p.K240*|ZC3H12C_uc001pkq.2_Nonsense_Mutation_p.K240*	NM_033390	NP_203748	Q9C0D7	ZC12C_HUMAN	zinc finger CCCH-type containing 12C	271							endonuclease activity|nucleic acid binding|zinc ion binding				0		all_cancers(61;3.24e-13)|all_epithelial(67;1.27e-07)|Melanoma(852;1.46e-05)|all_hematologic(158;3.66e-05)|Acute lymphoblastic leukemia(157;3.95e-05)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)|Breast(348;0.0544)		Epithelial(105;1.72e-06)|BRCA - Breast invasive adenocarcinoma(274;1.17e-05)|all cancers(92;9e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.0279)		CAGAGGAATAAAATTGGCAGT	0.363			NA											10	31					0	0	0.008291	0	0
RDX	5962	broad.mit.edu	37	11	110106875	110106875	+	Silent	SNP	T	T	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr11:110106875T>A	uc001pku.2	-	12	1603	c.1293A>T	c.(1291-1293)CTA>CTT	p.L431L	RDX_uc009yxx.1_RNA|RDX_uc009yxy.2_Silent_p.L431L|RDX_uc009yxz.2_Silent_p.L84L|RDX_uc009yya.2_Intron|RDX_uc001pks.2_5'UTR|RDX_uc001pkt.2_Silent_p.L85L|RDX_uc010rwe.1_Silent_p.L295L	NM_002906	NP_002897	P35241	RADI_HUMAN	radixin	431	Glu-rich.				actin filament capping	cleavage furrow|cytoskeleton|extrinsic to membrane|Golgi apparatus|nucleolus|plasma membrane	actin binding				0		all_cancers(61;7.18e-13)|all_epithelial(67;2.61e-07)|Melanoma(852;1.46e-05)|all_hematologic(158;3.66e-05)|Acute lymphoblastic leukemia(157;3.95e-05)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)|Breast(348;0.0544)		Epithelial(105;1.13e-06)|BRCA - Breast invasive adenocarcinoma(274;9.75e-06)|all cancers(92;5.9e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.0248)		TGGCTTCCTCTAGAAGTGCAA	0.313	Esophageal Squamous(55;25 1062 11040 28755 44273)		NA											13	169					0	0	0.00499	0	0
FAM55A	120400	broad.mit.edu	37	11	114401032	114401032	+	Missense_Mutation	SNP	T	T	C			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr11:114401032T>C	uc001ppa.2	-	3	689	c.272A>G	c.(271-273)TAT>TGT	p.Y91C	FAM55A_uc010rxd.1_Translation_Start_Site|FAM55A_uc001ppb.1_Missense_Mutation_p.Y233C	NM_152315	NP_689528	Q8N323	FA55A_HUMAN	hypothetical protein LOC120400	233						extracellular region					0		all_cancers(61;8.53e-16)|all_epithelial(67;1.71e-08)|all_hematologic(158;3.05e-05)|Melanoma(852;0.000902)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0194)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)|Prostate(24;0.0906)		BRCA - Breast invasive adenocarcinoma(274;3.02e-06)|Epithelial(105;0.000144)|all cancers(92;0.00106)		GTCATCCAGATATTCACAGAG	0.423			NA											5	135					0	0	0.001168	0	0
ARHGEF12	23365	broad.mit.edu	37	11	120298883	120298883	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr11:120298883C>T	uc001pxl.1	+	8	519	c.512C>T	c.(511-513)CCC>CTC	p.P171L	ARHGEF12_uc009zat.2_Missense_Mutation_p.P152L|ARHGEF12_uc010rzn.1_Missense_Mutation_p.P68L|ARHGEF12_uc009zau.1_Missense_Mutation_p.P68L	NM_015313	NP_056128	Q9NZN5	ARHGC_HUMAN	Rho guanine nucleotide exchange factor (GEF) 12	171					apoptosis|axon guidance|G-protein coupled receptor protein signaling pathway|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|membrane	G-protein-coupled receptor binding|GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			lung(2)|breast(2)|skin(2)|ovary(1)	7		Breast(109;0.000813)|Medulloblastoma(222;0.0425)|Hepatocellular(160;0.0831)|all_hematologic(192;0.107)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.231)		CATATGTCTCCCATCATGACA	0.498			NA	T	MLL	AML								5	347					0	0	0.000602	0	0
TBCEL	219899	broad.mit.edu	37	11	120924346	120924346	+	Silent	SNP	A	A	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr11:120924346A>T	uc009zay.2	+	4	438	c.360A>T	c.(358-360)ACA>ACT	p.T120T	TBCEL_uc001pxo.2_Silent_p.T120T|TBCEL_uc001pxp.2_5'UTR|TBCEL_uc001pxq.2_Intron	NM_001130047	NP_001123519	Q5QJ74	TBCEL_HUMAN	tubulin folding cofactor E-like	120	LRR 2.					cytoplasm|cytoskeleton				skin(1)	1		Breast(109;0.00526)|Medulloblastoma(222;0.0523)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;5.89e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.121)		TAGAAAGAACATGTGCTGGGT	0.433			NA											6	185					0	0	0.001168	0	0
SORL1	6653	broad.mit.edu	37	11	121429397	121429397	+	Nonsense_Mutation	SNP	A	A	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr11:121429397A>T	uc001pxx.2	+	20	2841	c.2761A>T	c.(2761-2763)AAG>TAG	p.K921*		NM_003105	NP_003096	Q92673	SORL_HUMAN	sortilin-related receptor containing LDLR class	921	Extracellular (Potential).|LDL-receptor class B 3.				cholesterol metabolic process|lipid transport|receptor-mediated endocytosis	integral to plasma membrane|low-density lipoprotein particle	low-density lipoprotein particle binding|transmembrane receptor activity			ovary(5)|breast(4)|large_intestine(2)|skin(2)|central_nervous_system(1)|pancreas(1)	15		Breast(109;0.00119)|Medulloblastoma(222;0.0429)|all_neural(223;0.113)		BRCA - Breast invasive adenocarcinoma(274;3.34e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.108)		TGAGGATGTGAAGTGGCCCAA	0.547			NA											6	245					0	0	0.00308	0	0
OR8D2	283160	broad.mit.edu	37	11	124189358	124189358	+	Silent	SNP	A	A	G			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr11:124189358A>G	uc010sah.1	-	1	736	c.736T>C	c.(736-738)TTG>CTG	p.L246L		NM_001002918	NP_001002918	Q9GZM6	OR8D2_HUMAN	olfactory receptor, family 8, subfamily D,	246	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|pancreas(1)	3		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0525)		CCCACAGCCAAGAGATGGGAG	0.438			NA											4	285					0	0	0.009096	0	0
OR8B2	26595	broad.mit.edu	37	11	124253151	124253151	+	Missense_Mutation	SNP	A	A	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr11:124253151A>T	uc010sai.1	-	1	89	c.89T>A	c.(88-90)CTG>CAG	p.L30Q	OR8B2_uc001qab.3_RNA	NM_001005468	NP_001005468	Q96RD0	OR8B2_HUMAN	olfactory receptor, family 8, subfamily B,	30	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0277)		CACTAGAAACAGGAAAAAGAG	0.418			NA											68	265					0	0	0.00361	0	0
CHEK1	1111	broad.mit.edu	37	11	125499354	125499354	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr11:125499354G>T	uc009zbo.2	+	5	1315	c.423G>T	c.(421-423)AGG>AGT	p.R141S	CHEK1_uc010sbh.1_Missense_Mutation_p.R157S|CHEK1_uc010sbi.1_Missense_Mutation_p.R141S|CHEK1_uc001qcf.3_Missense_Mutation_p.R141S|CHEK1_uc009zbp.2_Missense_Mutation_p.R141S|CHEK1_uc001qcg.3_Missense_Mutation_p.R141S|CHEK1_uc009zbq.2_Missense_Mutation_p.R141S|CHEK1_uc001qci.1_RNA	NM_001114122	NP_001107594	O14757	CHK1_HUMAN	checkpoint kinase 1	141	Protein kinase.				cellular response to mechanical stimulus|DNA repair|DNA replication|gamete generation|negative regulation of cell proliferation|reciprocal meiotic recombination|regulation of cyclin-dependent protein kinase activity|replicative senescence	condensed nuclear chromosome|microtubule organizing center|nucleoplasm	ATP binding|protein binding|protein serine/threonine kinase activity			central_nervous_system(3)|lung(2)|skin(1)	6	all_hematologic(175;0.228)	Breast(109;0.0021)|Lung NSC(97;0.0126)|all_lung(97;0.0132)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.13e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0748)		TGGATGAAAGGGGTAAGTTTA	0.274			NA						Other_conserved_DNA_damage_response_genes					38	50					2.54651e-27	4.15506e-27	0.006999	1	0
PRDM10	56980	broad.mit.edu	37	11	129785714	129785714	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr11:129785714C>G	uc001qfm.2	-	17	2611	c.2379G>C	c.(2377-2379)AAG>AAC	p.K793N	PRDM10_uc001qfj.2_Missense_Mutation_p.K707N|PRDM10_uc001qfk.2_Missense_Mutation_p.K703N|PRDM10_uc001qfl.2_Missense_Mutation_p.K707N|PRDM10_uc010sbx.1_Missense_Mutation_p.K703N|PRDM10_uc001qfn.2_Missense_Mutation_p.K789N|PRDM10_uc009zcs.1_5'UTR	NM_020228	NP_064613	Q9NQV6	PRD10_HUMAN	PR domain containing 10 isoform 1	793	C2H2-type 9.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			pancreas(1)	1	all_hematologic(175;0.0537)	Breast(109;0.000496)|Lung NSC(97;0.000693)|all_lung(97;0.00151)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.0174)|Lung(977;0.176)|LUSC - Lung squamous cell carcinoma(976;0.185)		CTGGGTGGTTCTTCAGAATGT	0.542			NA											20	225					0	0	0.007413	0	0
IQSEC3	440073	broad.mit.edu	37	12	266787	266787	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr12:266787C>A	uc001qhw.1	+	4	1467	c.1461C>A	c.(1459-1461)AAC>AAA	p.N487K	IQSEC3_uc001qhu.1_Missense_Mutation_p.N487K	NM_015232	NP_056047	Q9UPP2	IQEC3_HUMAN	IQ motif and Sec7 domain 3	790	SEC7.				regulation of ARF protein signal transduction	cytoplasm	ARF guanyl-nucleotide exchange factor activity			central_nervous_system(2)|large_intestine(1)|skin(1)	4	all_cancers(10;0.016)|all_lung(10;0.0222)|all_epithelial(11;0.0262)|Lung NSC(10;0.031)		OV - Ovarian serous cystadenocarcinoma(31;0.00456)	LUAD - Lung adenocarcinoma(1;0.172)|Lung(1;0.179)		TCCTCCTCAACACCGACATGT	0.582			NA											6	105					0.00116845	0.00127467	0.001168	1	0
KCNA1	3736	broad.mit.edu	37	12	5020837	5020837	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr12:5020837C>T	uc001qnh.2	+	2	1398	c.293C>T	c.(292-294)TCC>TTC	p.S98F		NM_000217	NP_000208	Q09470	KCNA1_HUMAN	potassium voltage-gated channel subfamily A	98					synaptic transmission	juxtaparanode region of axon|voltage-gated potassium channel complex	delayed rectifier potassium channel activity|potassium ion transmembrane transporter activity			ovary(1)|skin(1)	2					Desflurane(DB01189)|Enflurane(DB00228)|Isoflurane(DB00753)|Methoxyflurane(DB01028)|Sevoflurane(DB01236)	TACTACCAGTCCGGCGGCCGC	0.602			NA											6	29					0	0	0.001368	0	0
SLC2A3	6515	broad.mit.edu	37	12	8085705	8085705	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr12:8085705C>A	uc001qtr.2	-	3	409	c.147G>T	c.(145-147)AAG>AAT	p.K49N	SLC2A3_uc001qts.2_Missense_Mutation_p.K49N	NM_006931	NP_008862	P11169	GTR3_HUMAN	solute carrier family 2 (facilitated glucose	49	Extracellular (Potential).				carbohydrate metabolic process|water-soluble vitamin metabolic process	integral to membrane|plasma membrane	D-glucose transmembrane transporter activity|dehydroascorbic acid transporter activity			ovary(3)|pancreas(1)	4				Kidney(36;0.0866)		GGGCATTTCCCTTGTCCGTCA	0.463	Colon(96;424 1461 14416 20933 23688)		NA									OREG0021656	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	29	62					1.7881e-09	2.3708e-09	0.008361	1	0
TAS2R46	259292	broad.mit.edu	37	12	11214459	11214459	+	Missense_Mutation	SNP	A	A	C			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr12:11214459A>C	uc001qzp.1	-	1	435	c.435T>G	c.(433-435)TTT>TTG	p.F145L	PRR4_uc009zhp.2_Intron|PRH1_uc001qzb.3_Intron|PRH1_uc001qzc.2_Intron|PRB4_uc001qzf.1_Intron|PRH1_uc001qzj.2_Intron	NM_176887	NP_795368	P59540	T2R46_HUMAN	taste receptor, type 2, member 46	145	Helical; Name=4; (Potential).				sensory perception of taste	cilium membrane|integral to membrane	G-protein coupled receptor activity			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(49;0.0344)	BRCA - Breast invasive adenocarcinoma(232;0.196)		TGTTTATCACAAAAAGATGAC	0.348			NA											4	91					0	0	0.001984	0	0
ABCC9	10060	broad.mit.edu	37	12	21970121	21970121	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr12:21970121C>A	uc001rfi.1	-	31	3912	c.3892G>T	c.(3892-3894)GAT>TAT	p.D1298Y	ABCC9_uc001rfh.2_Missense_Mutation_p.D1298Y|ABCC9_uc001rfj.1_Missense_Mutation_p.D1262Y	NM_005691	NP_005682	O60706	ABCC9_HUMAN	ATP-binding cassette, sub-family C, member 9	1298	Cytoplasmic (Potential).				defense response to virus|potassium ion import	ATP-sensitive potassium channel complex	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium channel regulator activity|sulfonylurea receptor activity			ovary(4)|skin(2)	6					Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	AGAGCAATACCCATTGTGCCT	0.398			NA											47	91					1.30916e-28	2.1435e-28	0.00361	1	0
LRMP	4033	broad.mit.edu	37	12	25243005	25243005	+	Missense_Mutation	SNP	A	A	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr12:25243005A>T	uc001rgh.2	+	13	1514	c.480A>T	c.(478-480)AGA>AGT	p.R160S	LRMP_uc010sja.1_Missense_Mutation_p.R160S|LRMP_uc010sjb.1_Missense_Mutation_p.R107S|LRMP_uc001rgi.2_RNA|LRMP_uc010sjc.1_Missense_Mutation_p.R160S|LRMP_uc010sjd.1_Missense_Mutation_p.R107S	NM_006152	NP_006143	Q12912	LRMP_HUMAN	lymphoid-restricted membrane protein	216	Cytoplasmic (Potential).				vesicle fusion|vesicle targeting	endoplasmic reticulum membrane|integral to plasma membrane				ovary(1)|skin(1)	2	Acute lymphoblastic leukemia(6;0.00112)|all_hematologic(7;0.00152)|Colorectal(261;0.11)					AATTTCTCAGATTATCTTTGG	0.393			NA											27	182					0	0	0.002836	0	0
PPFIBP1	8496	broad.mit.edu	37	12	27835424	27835424	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr12:27835424G>T	uc001ric.1	+	22	2546	c.2169G>T	c.(2167-2169)TGG>TGT	p.W723C	PPFIBP1_uc010sjr.1_Missense_Mutation_p.W554C|PPFIBP1_uc001rib.1_Missense_Mutation_p.W717C|PPFIBP1_uc001ria.2_Missense_Mutation_p.W692C|PPFIBP1_uc001rid.1_Missense_Mutation_p.W570C|PPFIBP1_uc001rif.1_Missense_Mutation_p.W230C	NM_003622	NP_003613	Q86W92	LIPB1_HUMAN	PTPRF interacting protein binding protein 1	723	SAM 2.				cell adhesion	plasma membrane	protein binding		PPFIBP1/ALK(3)	soft_tissue(3)|kidney(1)|skin(1)	5	Lung SC(9;0.0873)					ATTTCAACTGGGTCACTAGTA	0.363			NA											49	120					1.86633e-21	2.92928e-21	0.00361	1	0
C12orf35	55196	broad.mit.edu	37	12	32137134	32137134	+	Missense_Mutation	SNP	A	A	G			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr12:32137134A>G	uc001rks.2	+	4	3659	c.3245A>G	c.(3244-3246)TAC>TGC	p.Y1082C	C12orf35_uc001rkt.2_5'Flank	NM_018169	NP_060639	Q9HCM1	CL035_HUMAN	hypothetical protein LOC55196	1082										ovary(1)|skin(1)	2	all_cancers(9;3.36e-11)|all_epithelial(9;2.56e-11)|all_lung(12;5.67e-10)|Acute lymphoblastic leukemia(23;0.0122)|Lung SC(12;0.0336)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.204)		OV - Ovarian serous cystadenocarcinoma(6;0.0114)			CAAACTACATACCAGACCTCA	0.403			NA											5	216					0	0	0.001168	0	0
KIF21A	55605	broad.mit.edu	37	12	39752118	39752118	+	Missense_Mutation	SNP	T	T	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr12:39752118T>A	uc001rly.2	-	8	1223	c.1077A>T	c.(1075-1077)TTA>TTT	p.L359F	KIF21A_uc001rlx.2_Missense_Mutation_p.L359F|KIF21A_uc001rlz.2_Missense_Mutation_p.L359F|KIF21A_uc010skl.1_Missense_Mutation_p.L359F|KIF21A_uc001rma.1_Missense_Mutation_p.L367F	NM_017641	NP_060111	Q7Z4S6	KI21A_HUMAN	kinesin family member 21A	359					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(4)|pancreas(1)|lung(1)|skin(1)	7		Lung NSC(34;0.179)|all_lung(34;0.213)				TCAGGGTGTTTAACGTTTCCA	0.393			NA											48	357					0	0	0.00361	0	0
ADAMTS20	80070	broad.mit.edu	37	12	43826240	43826240	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr12:43826240G>T	uc010skx.1	-	21	2963	c.2963C>A	c.(2962-2964)TCT>TAT	p.S988Y	ADAMTS20_uc001rno.1_Missense_Mutation_p.S142Y|ADAMTS20_uc001rnp.1_Missense_Mutation_p.S142Y	NM_025003	NP_079279	P59510	ATS20_HUMAN	a disintegrin-like and metalloprotease with	988	TSP type-1 4.					proteinaceous extracellular matrix	zinc ion binding			central_nervous_system(5)|ovary(4)|lung(3)|large_intestine(2)|skin(2)|urinary_tract(1)|kidney(1)|pancreas(1)	19	all_cancers(12;2.6e-05)|Lung SC(27;0.184)	Lung NSC(34;0.0569)|all_lung(34;0.129)		GBM - Glioblastoma multiforme(48;0.0473)		AGATTCTCGAGACCTTTCCCC	0.373			NA											12	78					2.27111e-07	2.78527e-07	0.001368	1	0
PUS7L	83448	broad.mit.edu	37	12	44130285	44130285	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr12:44130285C>G	uc001rnq.3	-	7	2113	c.1624G>C	c.(1624-1626)GCA>CCA	p.A542P	PUS7L_uc001rnr.3_Missense_Mutation_p.A542P|PUS7L_uc001rns.3_Missense_Mutation_p.A542P|PUS7L_uc009zkb.2_Missense_Mutation_p.A229P	NM_001098615	NP_001092085	Q9H0K6	PUS7L_HUMAN	pseudouridylate synthase 7 homolog (S.	542	TRUD.				pseudouridine synthesis|tRNA processing		pseudouridine synthase activity|RNA binding			pancreas(1)	1	all_cancers(12;0.00027)	Lung NSC(34;0.114)|all_lung(34;0.24)		GBM - Glioblastoma multiforme(48;0.0402)		TAAGATACTGCCTCATTCCAA	0.428			NA											8	183					0	0	0.00308	0	0
PUS7L	83448	broad.mit.edu	37	12	44136349	44136349	+	Missense_Mutation	SNP	A	A	C			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr12:44136349A>C	uc001rnq.3	-	5	1762	c.1273T>G	c.(1273-1275)TTT>GTT	p.F425V	PUS7L_uc001rnr.3_Missense_Mutation_p.F425V|PUS7L_uc001rns.3_Missense_Mutation_p.F425V|PUS7L_uc009zkb.2_Missense_Mutation_p.F112V	NM_001098615	NP_001092085	Q9H0K6	PUS7L_HUMAN	pseudouridylate synthase 7 homolog (S.	425	TRUD.				pseudouridine synthesis|tRNA processing		pseudouridine synthase activity|RNA binding			pancreas(1)	1	all_cancers(12;0.00027)	Lung NSC(34;0.114)|all_lung(34;0.24)		GBM - Glioblastoma multiforme(48;0.0402)		TAATTCACAAAGCCTTTTTTC	0.294			NA											6	132					0	0	0.001168	0	0
CCDC65	85478	broad.mit.edu	37	12	49315194	49315195	+	Missense_Mutation	DNP	CA	CA	AT			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	CA	CA	-	-	CA	CA	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr12:49315194_49315195CA>AT	uc001rso.2	+	8	1650_1651	c.1423_1424CA>AT	c.(1423-1425)CAT>ATT	p.H475I		NM_033124	NP_149115	Q8IXS2	CCD65_HUMAN	coiled-coil domain containing 65	475										ovary(1)|skin(1)	2						ACGTATAGCCCATCCAGGTGAT	0.426			NA											12	189					0	0	0.004672	0	0
KRT75	9119	broad.mit.edu	37	12	52818459	52818459	+	Missense_Mutation	SNP	T	T	G			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr12:52818459T>G	uc001saj.2	-	9	1520	c.1498A>C	c.(1498-1500)AGC>CGC	p.S500R		NM_004693	NP_004684	O95678	K2C75_HUMAN	keratin 75	500	Tail.					keratin filament	structural molecule activity				0				BRCA - Breast invasive adenocarcinoma(357;0.192)		GAGTAGCCGCTGCCCCCACCG	0.632			NA											4	65					0	0	0.001168	0	0
KRT75	9119	broad.mit.edu	37	12	52822519	52822519	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr12:52822519C>G	uc001saj.2	-	6	1066	c.1044G>C	c.(1042-1044)GAG>GAC	p.E348D		NM_004693	NP_004684	O95678	K2C75_HUMAN	keratin 75	348	Coil 2.|Rod.					keratin filament	structural molecule activity				0				BRCA - Breast invasive adenocarcinoma(357;0.192)		TGACCTGCAGCTCCTCGTACT	0.557			NA											5	133					0	0	0.001168	0	0
AMHR2	269	broad.mit.edu	37	12	53819601	53819601	+	Silent	SNP	A	A	G			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr12:53819601A>G	uc001scx.1	+	6	828	c.750A>G	c.(748-750)CCA>CCG	p.P250P	AMHR2_uc009zmy.1_Silent_p.P250P	NM_020547	NP_065434	Q16671	AMHR2_HUMAN	anti-Mullerian hormone receptor, type II isoform	250	Cytoplasmic (Potential).|Protein kinase.				Mullerian duct regression		ATP binding|hormone binding|metal ion binding			ovary(1)|skin(1)	2					Adenosine triphosphate(DB00171)	ACGAACTTCCAGGCCTACAGC	0.597			NA							Persistant_Mullerian_Duct_Syndrome_(type_I_and_II)				3	79					0	0	0.004672	0	0
NCKAP1L	3071	broad.mit.edu	37	12	54925124	54925124	+	Nonsense_Mutation	SNP	C	C	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr12:54925124C>T	uc001sgc.3	+	23	2666	c.2587C>T	c.(2587-2589)CAG>TAG	p.Q863*	NCKAP1L_uc010sox.1_Nonsense_Mutation_p.Q405*|NCKAP1L_uc010soy.1_Nonsense_Mutation_p.Q813*	NM_005337	NP_005328	P55160	NCKPL_HUMAN	NCK-associated protein 1-like	863					actin polymerization-dependent cell motility|B cell homeostasis|B cell receptor signaling pathway|cortical actin cytoskeleton organization|erythrocyte development|maintenance of cell polarity|myeloid cell homeostasis|negative regulation of apoptosis|negative regulation of interleukin-17 production|negative regulation of interleukin-6 production|negative regulation of myosin-light-chain-phosphatase activity|neutrophil chemotaxis|positive regulation of actin filament polymerization|positive regulation of B cell differentiation|positive regulation of B cell proliferation|positive regulation of CD4-positive, alpha-beta T cell differentiation|positive regulation of CD8-positive, alpha-beta T cell differentiation|positive regulation of cell adhesion mediated by integrin|positive regulation of erythrocyte differentiation|positive regulation of gamma-delta T cell differentiation|positive regulation of neutrophil chemotaxis|positive regulation of phagocytosis, engulfment|positive regulation of T cell proliferation|protein complex assembly|response to drug|T cell homeostasis	cytosol|integral to plasma membrane|membrane fraction|SCAR complex	protein complex binding|protein kinase activator activity|Rac GTPase activator activity			ovary(3)|central_nervous_system(1)	4						TGTGACCTCTCAGATTGTGGA	0.512			NA											8	291					0	0	0.00308	0	0
OR9K2	441639	broad.mit.edu	37	12	55524459	55524459	+	Silent	SNP	C	C	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr12:55524459C>T	uc010spe.1	+	1	907	c.907C>T	c.(907-909)CTA>TTA	p.L303L		NM_001005243	NP_001005243	Q8NGE7	OR9K2_HUMAN	olfactory receptor, family 9, subfamily K,	303					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|pancreas(1)	2						ATGTTACTCCCTAGTCACTCC	0.393			NA											45	132					0	0	0.00361	0	0
OR6C1	390321	broad.mit.edu	37	12	55715313	55715313	+	Silent	SNP	A	A	C			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr12:55715313A>C	uc010spi.1	+	1	930	c.930A>C	c.(928-930)ACA>ACC	p.T310T		NM_001005182	NP_001005182	Q96RD1	OR6C1_HUMAN	olfactory receptor, family 6, subfamily C,	310	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(1)|ovary(1)	2						TATTTTTCACAAGCACATGAA	0.408			NA											30	213					0	0	0.009535	0	0
METTL7B	196410	broad.mit.edu	37	12	56075950	56075950	+	Missense_Mutation	SNP	A	A	G			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr12:56075950A>G	uc010spr.1	+	1	621	c.412A>G	c.(412-414)ATG>GTG	p.M138V		NM_152637	NP_689850	Q6UX53	MET7B_HUMAN	methyltransferase like 7B precursor	138							methyltransferase activity				0						TGATGGCTCCATGGATGTGGT	0.577			NA											11	50					0	0	0.001368	0	0
SILV	6490	broad.mit.edu	37	12	56355437	56355437	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr12:56355437C>A	uc001sip.2	-	2	187	c.156G>T	c.(154-156)TGG>TGT	p.W52C	SILV_uc001siq.2_Missense_Mutation_p.W52C|SILV_uc010spx.1_Intron|SILV_uc001sir.2_Missense_Mutation_p.W52C	NM_006928	NP_008859	P40967	PMEL_HUMAN	silver homolog	52					melanin biosynthetic process|melanosome organization	endoplasmic reticulum membrane|extracellular region|Golgi apparatus|integral to membrane|melanosome|multivesicular body membrane|plasma membrane	protein binding				0						GGGCTTCTGTCCACTCTGGAT	0.522			NA											28	178					4.02929e-09	5.27592e-09	0.002096	1	0
ARHGAP9	64333	broad.mit.edu	37	12	57870424	57870424	+	Missense_Mutation	SNP	T	T	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr12:57870424T>A	uc001sod.2	-	10	1380	c.1187A>T	c.(1186-1188)AAG>ATG	p.K396M	ARHGAP9_uc001sny.2_5'Flank|ARHGAP9_uc001snz.2_Missense_Mutation_p.K141M|ARHGAP9_uc001soa.2_Translation_Start_Site|ARHGAP9_uc001sob.2_Missense_Mutation_p.K325M|ARHGAP9_uc001soc.2_Missense_Mutation_p.K325M|ARHGAP9_uc001soe.1_Missense_Mutation_p.K404M	NM_032496	NP_115885	Q9BRR9	RHG09_HUMAN	Rho GTPase activating protein 9 isoform 1	325	PH.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|protein binding			lung(1)	1			GBM - Glioblastoma multiforme(3;3.37e-34)			CAGACCCGACTTTTCCACCTC	0.582			NA											5	187					0	0	0.000602	0	0
XPOT	11260	broad.mit.edu	37	12	64814133	64814133	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr12:64814133G>T	uc001ssb.2	+	8	1101	c.675G>T	c.(673-675)AGG>AGT	p.R225S	XPOT_uc009zqm.1_Missense_Mutation_p.R135S	NM_007235	NP_009166	O43592	XPOT_HUMAN	tRNA exportin	225	Necessary for interaction with Ran, nuclear localization and nuclear import.				intracellular protein transport|tRNA export from nucleus	cytoplasm|nucleoplasm	protein transporter activity|tRNA binding			ovary(2)	2				GBM - Glioblastoma multiforme(28;0.0404)		CCATTACCAGGTTTATAAATA	0.308			NA											39	96					5.43694e-19	8.29986e-19	0.005524	1	0
GRIP1	23426	broad.mit.edu	37	12	66814542	66814542	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr12:66814542G>T	uc001stk.2	-	14	1881	c.1640C>A	c.(1639-1641)CCC>CAC	p.P547H	GRIP1_uc010sta.1_Missense_Mutation_p.P491H|GRIP1_uc001stj.2_Missense_Mutation_p.P329H|GRIP1_uc001stl.1_Missense_Mutation_p.P439H|GRIP1_uc001stm.2_Missense_Mutation_p.P547H	NM_021150	NP_066973	Q9Y3R0	GRIP1_HUMAN	glutamate receptor interacting protein 1	599	PDZ 5.				androgen receptor signaling pathway|intracellular signal transduction|positive regulation of transcription, DNA-dependent|synaptic transmission	cell junction|cytoplasmic membrane-bounded vesicle|cytosol|endoplasmic reticulum|postsynaptic membrane	androgen receptor binding|beta-catenin binding|protein C-terminus binding|receptor signaling complex scaffold activity|transcription coactivator activity			ovary(2)	2			GBM - Glioblastoma multiforme(2;0.00069)	GBM - Glioblastoma multiforme(28;0.0933)		AATGACGAGGGGGTCTCCTGG	0.378			NA											70	157					9.42754e-34	1.55162e-33	0.00361	1	0
TRHDE	29953	broad.mit.edu	37	12	72667204	72667204	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr12:72667204G>T	uc001sxa.2	+	1	676	c.646G>T	c.(646-648)GTC>TTC	p.V216F	LOC283392_uc010stv.1_5'UTR	NM_013381	NP_037513	Q9UKU6	TRHDE_HUMAN	thyrotropin-releasing hormone degrading enzyme	216	Extracellular (Potential).				cell-cell signaling|proteolysis|signal transduction	integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|zinc ion binding			ovary(2)|skin(1)	3						GCAAACCCAGGTCTTAGTGGT	0.567			NA											11	120					2.80697e-09	3.69072e-09	0.000978	1	0
CAPS2	84698	broad.mit.edu	37	12	75692486	75692486	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr12:75692486C>A	uc001sxk.3	-	12	1279	c.1082G>T	c.(1081-1083)CGA>CTA	p.R361L	CAPS2_uc001sxm.3_Missense_Mutation_p.R129L|CAPS2_uc009zsa.2_Intron|CAPS2_uc001sxi.3_Missense_Mutation_p.R97L|CAPS2_uc001sxj.3_Missense_Mutation_p.R272L|CAPS2_uc001sxl.3_Missense_Mutation_p.R342L	NM_032606	NP_115995	Q9BXY5	CAYP2_HUMAN	calcyphosine 2	361							calcium ion binding			ovary(2)	2						ATCACCAAGTCGGTATTGTTT	0.378			NA											25	34					4.7796e-09	6.23255e-09	0.004656	1	0
NAV3	89795	broad.mit.edu	37	12	78444710	78444710	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr12:78444710G>C	uc001syp.2	+	11	2472	c.2299G>C	c.(2299-2301)GGT>CGT	p.G767R	NAV3_uc001syo.2_Missense_Mutation_p.G767R|NAV3_uc010sub.1_Missense_Mutation_p.G267R	NM_014903	NP_055718	Q8IVL0	NAV3_HUMAN	neuron navigator 3	767						nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			large_intestine(6)|ovary(5)|lung(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	17						TCCTCGCAGTGGTACCAGTCG	0.592			NA								HNSCC(70;0.22)			12	65					0	0	0.001368	0	0
ELK3	2004	broad.mit.edu	37	12	96641401	96641401	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr12:96641401G>T	uc001teo.1	+	3	1170	c.891G>T	c.(889-891)TTG>TTT	p.L297F		NM_005230	NP_005221	P41970	ELK3_HUMAN	ELK3 protein	297					negative regulation of transcription, DNA-dependent|signal transduction	mitochondrion	protein binding|purine-rich negative regulatory element binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			ovary(1)	1	all_cancers(2;0.00173)					CCAAAGGCTTGGAAATCTCAG	0.617			NA											11	85					5.16669e-11	7.16085e-11	0.000978	1	0
APAF1	317	broad.mit.edu	37	12	99074148	99074148	+	Missense_Mutation	SNP	A	A	G			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr12:99074148A>G	uc001tfz.2	+	14	2591	c.2014A>G	c.(2014-2016)ATA>GTA	p.I672V	APAF1_uc001tfy.2_Missense_Mutation_p.I661V|APAF1_uc001tga.2_Missense_Mutation_p.I661V|APAF1_uc001tgb.2_Missense_Mutation_p.I672V|APAF1_uc001tgc.2_Intron|APAF1_uc009zto.2_Missense_Mutation_p.I81V	NM_181861	NP_863651	O14727	APAF_HUMAN	apoptotic peptidase activating factor 1 isoform	672	WD 2.				activation of caspase activity by cytochrome c|defense response|induction of apoptosis by intracellular signals|nervous system development	cytosol|Golgi apparatus|nucleus	ATP binding|caspase activator activity|protein binding			ovary(2)|lung(1)	3					Adenosine triphosphate(DB00171)	TGACAGATTTATAGCAACCTG	0.373			NA											17	27					0	0	0.010504	0	0
SLC17A8	246213	broad.mit.edu	37	12	100774686	100774686	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr12:100774686G>A	uc010svi.1	+	2	622	c.309G>A	c.(307-309)ATG>ATA	p.M103I	SLC17A8_uc009ztx.2_Missense_Mutation_p.M103I	NM_139319	NP_647480	Q8NDX2	VGLU3_HUMAN	solute carrier family 17 (sodium-dependent	103	Vesicular (Potential).				neurotransmitter transport|sensory perception of sound|sodium ion transport	cell junction|integral to membrane|synaptic vesicle membrane|synaptosome	L-glutamate transmembrane transporter activity|symporter activity			ovary(3)	3						TTGTGGAAATGGTCAACAATA	0.413			NA											22	149					0	0	0.00333	0	0
NR1H4	9971	broad.mit.edu	37	12	100928738	100928738	+	Silent	SNP	C	C	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr12:100928738C>A	uc001tht.1	+	4	727	c.699C>A	c.(697-699)ACC>ACA	p.T233T	NR1H4_uc001thp.1_Silent_p.T219T|NR1H4_uc001thq.1_Silent_p.T223T|NR1H4_uc010svj.1_RNA|NR1H4_uc001thr.1_Silent_p.T223T|NR1H4_uc010svk.1_Silent_p.T172T|NR1H4_uc001ths.1_Silent_p.T229T	NM_005123	NP_005114	Q96RI1	NR1H4_HUMAN	nuclear receptor subfamily 1, group H, member 4	233					bile acid metabolic process|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|thyroid hormone receptor activity|transcription coactivator activity|transcription corepressor activity|zinc ion binding			ovary(1)|lung(1)|skin(1)	3						CAGATCAGACCGTGAATGAAG	0.428			NA											30	56					3.11337e-16	4.648e-16	0.002836	1	0
POLR3B	55703	broad.mit.edu	37	12	106890686	106890686	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr12:106890686G>A	uc001tlp.2	+	25	3196	c.2974G>A	c.(2974-2976)GGC>AGC	p.G992S	POLR3B_uc001tlq.2_Missense_Mutation_p.G934S	NM_018082	NP_060552	Q9NW08	RPC2_HUMAN	DNA-directed RNA polymerase III B isoform 1	992					innate immune response|positive regulation of innate immune response|positive regulation of interferon-beta production|response to virus|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase III promoter	nucleoplasm	DNA binding|DNA-directed RNA polymerase activity|metal ion binding|ribonucleoside binding			ovary(1)|central_nervous_system(1)	2						TGTTACATCCGGCATCACAGG	0.428			NA											21	153					0	0	0.001882	0	0
CRY1	1407	broad.mit.edu	37	12	107393382	107393382	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr12:107393382C>A	uc001tmi.3	-	7	1943	c.1084G>T	c.(1084-1086)GCT>TCT	p.A362S		NM_004075	NP_004066	Q16526	CRY1_HUMAN	cryptochrome 1 (photolyase-like)	362	FAD-binding.				DNA repair|protein-chromophore linkage|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	blue light photoreceptor activity|DNA photolyase activity|double-stranded DNA binding|nucleotide binding|protein binding			ovary(3)	3						AGGAAGCAAGCAACTGCATGC	0.483			NA											23	85					6.12954e-19	9.34212e-19	0.004656	1	0
BTBD11	121551	broad.mit.edu	37	12	108051444	108051444	+	Silent	SNP	C	C	G			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr12:108051444C>G	uc001tmk.1	+	17	3785	c.3264C>G	c.(3262-3264)GCC>GCG	p.A1088A	BTBD11_uc001tml.1_Silent_p.A625A|BTBD11_uc001tmm.1_Silent_p.A167A	NM_001018072	NP_001018082	A6QL63	BTBDB_HUMAN	BTB (POZ) domain containing 11 isoform a	1088						integral to membrane	DNA binding			skin(2)|ovary(1)	3						GGACGTTGGCCATCAGAATTC	0.512			NA											5	111					0	0	0.001168	0	0
ACACB	32	broad.mit.edu	37	12	109637270	109637270	+	Silent	SNP	G	G	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr12:109637270G>T	uc001tob.2	+	18	2810	c.2691G>T	c.(2689-2691)CTG>CTT	p.L897L	ACACB_uc001toc.2_Silent_p.L897L	NM_001093	NP_001084	O00763	ACACB_HUMAN	acetyl-Coenzyme A carboxylase beta	897	Biotinyl-binding.				acetyl-CoA metabolic process|carnitine shuttle|energy reserve metabolic process|fatty acid biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|regulation of fatty acid oxidation	cytosol|endomembrane system|Golgi apparatus|membrane	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			ovary(5)|upper_aerodigestive_tract(1)|pancreas(1)|skin(1)	8					Biotin(DB00121)	CTACAGTCCTGAGATCCCCCT	0.562			NA											10	118					0.00244969	0.00263301	0.00245	1	0
C12orf51	283450	broad.mit.edu	37	12	112665893	112665893	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr12:112665893C>A	uc009zwc.2	-	36	5606	c.5588G>T	c.(5587-5589)AGA>ATA	p.R1863I	C12orf51_uc001ttr.1_Missense_Mutation_p.R38I	NM_001109662	NP_001103132			chromosome 12 open reading frame 51											ovary(1)|lung(1)	2						GGGTACTCACCTTGTCCTTAT	0.532			NA											44	88					1.51926e-22	2.40443e-22	0.00361	1	0
NCOR2	9612	broad.mit.edu	37	12	124862883	124862883	+	Silent	SNP	C	C	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr12:124862883C>A	uc010tba.1	-	18	2184	c.2067G>T	c.(2065-2067)GCG>GCT	p.A689A	NCOR2_uc010tay.1_Silent_p.A689A|NCOR2_uc010taz.1_Silent_p.A689A|NCOR2_uc010tbb.1_Silent_p.A689A|NCOR2_uc010tbc.1_Silent_p.A688A|NCOR2_uc001ugj.1_Silent_p.A689A	NM_001077261	NP_001070729	Q9Y618	NCOR2_HUMAN	nuclear receptor co-repressor 2 isoform 2	689					cellular lipid metabolic process|negative regulation of transcription from RNA polymerase II promoter|regulation of cellular ketone metabolic process by negative regulation of transcription from an RNA polymerase II promoter|transcription, DNA-dependent	nuclear body|nucleus|transcriptional repressor complex	DNA binding|histone deacetylase binding|Notch binding|protein N-terminus binding|transcription corepressor activity			skin(3)|ovary(1)	4	all_neural(191;0.0804)|Medulloblastoma(191;0.163)			Epithelial(86;3.99e-05)|OV - Ovarian serous cystadenocarcinoma(86;9.14e-05)|all cancers(50;0.000402)|BRCA - Breast invasive adenocarcinoma(302;0.0764)		CCTCGCTGGCCGCCGCCGGCG	0.657			NA											7	30					0.00621372	0.00658168	0.006214	1	0
TMEM132D	121256	broad.mit.edu	37	12	129559152	129559152	+	Silent	SNP	C	C	G			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr12:129559152C>G	uc009zyl.1	-	9	2896	c.2568G>C	c.(2566-2568)ACG>ACC	p.T856T	TMEM132D_uc001uia.2_Silent_p.T394T	NM_133448	NP_597705	Q14C87	T132D_HUMAN	transmembrane protein 132D precursor	856	Extracellular (Potential).					integral to membrane				ovary(10)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	14	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0934)|Breast(359;0.133)		OV - Ovarian serous cystadenocarcinoma(86;0.000288)|Epithelial(86;0.0116)|all cancers(50;0.0246)		ACCTGTCTGTCGTGGTGCCCC	0.552			NA											10	84					0	0	0.008291	0	0
CHFR	55743	broad.mit.edu	37	12	133447364	133447364	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr12:133447364C>A	uc001ulf.2	-	5	433	c.349G>T	c.(349-351)GCA>TCA	p.A117S	CHFR_uc001ulc.1_RNA|CHFR_uc001ule.2_Missense_Mutation_p.A117S|CHFR_uc010tbs.1_Missense_Mutation_p.A117S|CHFR_uc001uld.2_Missense_Mutation_p.A117S|CHFR_uc010tbt.1_Intron	NM_001161344	NP_001154816	Q96EP1	CHFR_HUMAN	checkpoint with forkhead and ring finger domains	117					cell division|mitosis|mitotic cell cycle checkpoint|modification-dependent protein catabolic process|protein polyubiquitination	PML body	nucleotide binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			skin(1)	1	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_cancers(7;0.00552)|all_epithelial(31;0.226)		OV - Ovarian serous cystadenocarcinoma(86;2.59e-08)|Epithelial(86;6.38e-07)|all cancers(50;1.56e-05)		TAGAGGTATGCCACGTCTAAA	0.388			NA											13	118					1.5842e-08	2.04052e-08	0.001855	1	0
SHISA2	387914	broad.mit.edu	37	13	26620787	26620787	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr13:26620787G>A	uc001uqm.1	-	2	837	c.752C>T	c.(751-753)ACG>ATG	p.T251M		NM_001007538	NP_001007539	Q6UWI4	SHSA2_HUMAN	shisa homolog 2 precursor	251	Cytoplasmic (Potential).				multicellular organismal development	endoplasmic reticulum membrane|integral to membrane				ovary(1)|central_nervous_system(1)	2						GTGCTGCACCGTGTACCCCAC	0.577			NA											38	40					0	0	0.007835	0	0
FAM10A4	145165	broad.mit.edu	37	13	50746537	50746537	+	Nonsense_Mutation	SNP	G	G	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr13:50746537G>T	uc001vej.2	+	1	384	c.313G>T	c.(313-315)GAG>TAG	p.E105*	DLEU1_uc010adl.1_Intron|DLEU1_uc001vee.1_Intron|DLEU1_uc010adm.1_Intron|DLEU1_uc010adn.1_Intron|DLEU1_uc001vef.1_Intron|DLEU1_uc001veg.1_Intron|DLEU1_uc010tgn.1_Intron|DLEU1_uc001vei.1_Intron|DLEU1_uc010ado.1_Intron|DLEU1_uc010adp.1_Intron	NR_002183				SubName: Full=ST13 protein;												0						GATAACAGAGGAGGTGATGGA	0.408			NA											16	27					3.62473e-10	4.91595e-10	0.001882	1	0
NEK3	4752	broad.mit.edu	37	13	52709865	52709865	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr13:52709865C>A	uc001vgi.2	-	16	1544	c.1309G>T	c.(1309-1311)GGT>TGT	p.G437C	NEK3_uc001vgg.2_Missense_Mutation_p.G414C|NEK3_uc001vgh.2_Missense_Mutation_p.G441C|NEK3_uc010tgx.1_RNA|NEK3_uc010tgy.1_Missense_Mutation_p.G420C	NM_152720	NP_689933	P51956	NEK3_HUMAN	NIMA-related kinase 3 isoform a	437					cell division|mitosis	nucleus	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			ovary(1)|stomach(1)	2		Breast(56;0.000207)|Lung NSC(96;0.00145)|Prostate(109;0.034)|Hepatocellular(98;0.065)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;2.81e-08)		CATGAATTACCTGGTCTATAT	0.294			NA											7	30					2.0095e-06	2.40531e-06	0.001984	1	0
PCDH17	27253	broad.mit.edu	37	13	58207531	58207531	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr13:58207531G>T	uc001vhq.1	+	1	1743	c.851G>T	c.(850-852)AGC>ATC	p.S284I	PCDH17_uc010aec.1_Missense_Mutation_p.S284I	NM_001040429	NP_001035519	O14917	PCD17_HUMAN	protocadherin 17 precursor	284	Extracellular (Potential).|Cadherin 3.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			ovary(3)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	7		Lung NSC(96;0.027)|Prostate(109;0.0453)|Breast(118;0.128)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;1.06e-05)		TCTTTCAGCAGCTACGTGCCT	0.582	Melanoma(72;952 1291 1619 12849 33676)		NA											8	58					0.000157383	0.000176986	0.00308	1	0
ABCC4	10257	broad.mit.edu	37	13	95829973	95829973	+	Missense_Mutation	SNP	T	T	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr13:95829973T>A	uc001vmd.3	-	13	1834	c.1715A>T	c.(1714-1716)CAC>CTC	p.H572L	ABCC4_uc010afk.2_Missense_Mutation_p.H572L|ABCC4_uc001vme.2_Missense_Mutation_p.H572L|ABCC4_uc010tih.1_Missense_Mutation_p.H497L|ABCC4_uc001vmf.2_Missense_Mutation_p.H529L|ABCC4_uc010afl.1_Missense_Mutation_p.H529L|ABCC4_uc010afm.1_Missense_Mutation_p.H585L	NM_005845	NP_005836	O15439	MRP4_HUMAN	ATP-binding cassette, sub-family C, member 4	572	ABC transporter 1.				platelet activation|platelet degranulation	integral to membrane|membrane fraction|plasma membrane|platelet dense granule membrane	15-hydroxyprostaglandin dehydrogenase (NAD+) activity|ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|chloride channel activity			central_nervous_system(3)|skin(1)	4	all_neural(89;0.0878)|Medulloblastoma(90;0.163)				Cefazolin(DB01327)	TTCGAACAAGTGTCTGCTAAC	0.443			NA											13	37					0	0	0.001855	0	0
DZIP1	22873	broad.mit.edu	37	13	96293708	96293708	+	Silent	SNP	C	C	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr13:96293708C>T	uc001vmk.2	-	5	1290	c.438G>A	c.(436-438)GAG>GAA	p.E146E	DZIP1_uc001vml.2_Silent_p.E146E|DZIP1_uc001vmn.2_Silent_p.E135E	NM_198968	NP_945319	Q86YF9	DZIP1_HUMAN	DAZ interacting protein 1 isoform 2	146					germ cell development|multicellular organismal development|spermatogenesis	cytoplasm|nucleus	nucleic acid binding|protein binding|zinc ion binding			ovary(2)	2	all_neural(89;0.0878)|Breast(111;0.148)|Medulloblastoma(90;0.163)		BRCA - Breast invasive adenocarcinoma(86;0.141)			GCAGCCGCTCCTCCAGGGTGT	0.617			NA											10	22					0	0	0.008291	0	0
NALCN	259232	broad.mit.edu	37	13	101710333	101710333	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr13:101710333C>A	uc001vox.1	-	43	5170	c.4981G>T	c.(4981-4983)GGG>TGG	p.G1661W		NM_052867	NP_443099	Q8IZF0	NALCN_HUMAN	voltage gated channel like 1	1661	Cytoplasmic (Potential).					integral to membrane	sodium channel activity|voltage-gated ion channel activity			ovary(8)|breast(4)|skin(2)|pancreas(1)|central_nervous_system(1)	16	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					TGGGGTTTCCCTGCGTCGGCT	0.567			NA											19	61					8.00594e-06	9.4516e-06	0.007413	1	0
P704P	641455	broad.mit.edu	37	14	20010235	20010235	+	Missense_Mutation	SNP	A	A	G			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr14:20010235A>G	uc001vwc.3	-	5	975	c.923T>C	c.(922-924)GTT>GCT	p.V308A	P704P_uc001vwb.3_RNA|uc001vwd.2_RNA	NM_001145442	NP_001138914	A6NI47	POTEM_HUMAN	prostate-specific P704P	308	ANK 5.										0						AAGTATGAGAACAGTTCTAAA	0.368			NA											3	116					0	0	0.004672	0	0
OR4Q3	441669	broad.mit.edu	37	14	20216282	20216282	+	Silent	SNP	G	G	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr14:20216282G>A	uc010tkt.1	+	1	696	c.696G>A	c.(694-696)CAG>CAA	p.Q232Q		NM_172194	NP_751944	Q8NH05	OR4Q3_HUMAN	olfactory receptor, family 4, subfamily Q,	232	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(3)	3	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		ACTTCTGCCAGGGCCAGAACA	0.488			NA											19	202					0	0	0.008871	0	0
OR4K1	79544	broad.mit.edu	37	14	20403987	20403987	+	Silent	SNP	T	T	C			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr14:20403987T>C	uc001vwj.1	+	1	162	c.162T>C	c.(160-162)CAT>CAC	p.H54H		NM_001004063	NP_001004063	Q8NGD4	OR4K1_HUMAN	olfactory receptor, family 4, subfamily K,	54	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)	3	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00124)		TTGACTCCCATTTGAACTCTC	0.363			NA											34	428					0	0	0.002836	0	0
OR4N5	390437	broad.mit.edu	37	14	20612039	20612039	+	Missense_Mutation	SNP	A	A	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr14:20612039A>T	uc010tla.1	+	1	145	c.145A>T	c.(145-147)ATA>TTA	p.I49L		NM_001004724	NP_001004724	Q8IXE1	OR4N5_HUMAN	olfactory receptor, family 4, subfamily N,	49	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	all_cancers(95;0.00108)		Epithelial(56;7.58e-07)|all cancers(55;3.84e-06)	GBM - Glioblastoma multiforme(265;0.0143)		CATTTTCACCATAAAGTCAGA	0.463			NA											111	250					0	0	0.00361	0	0
OR4N5	390437	broad.mit.edu	37	14	20612550	20612550	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr14:20612550C>A	uc010tla.1	+	1	656	c.656C>A	c.(655-657)GCA>GAA	p.A219E		NM_001004724	NP_001004724	Q8IXE1	OR4N5_HUMAN	olfactory receptor, family 4, subfamily N,	219	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	all_cancers(95;0.00108)		Epithelial(56;7.58e-07)|all cancers(55;3.84e-06)	GBM - Glioblastoma multiforme(265;0.0143)		GCCTCCTATGCAGTCATCCTC	0.502			NA											7	156					2.0095e-06	2.40531e-06	0.001984	1	0
OR11G2	390439	broad.mit.edu	37	14	20665955	20665955	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr14:20665955C>A	uc010tlb.1	+	1	461	c.461C>A	c.(460-462)GCA>GAA	p.A154E		NM_001005503	NP_001005503	Q8NGC1	O11G2_HUMAN	olfactory receptor, family 11, subfamily G,	154	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	all_cancers(95;0.00108)		Epithelial(56;9.76e-07)|all cancers(55;5.61e-06)	GBM - Glioblastoma multiforme(265;0.0144)		TTTTTCCTGGCAGTTATGGCA	0.478			NA											16	50					1.15088e-07	1.42432e-07	0.004007	1	0
TEP1	7011	broad.mit.edu	37	14	20852618	20852618	+	Missense_Mutation	SNP	C	C	A	rs147687706	byFrequency	TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr14:20852618C>A	uc001vxe.2	-	23	3311	c.3271G>T	c.(3271-3273)GGG>TGG	p.G1091W	TEP1_uc010ahk.2_Missense_Mutation_p.G441W|TEP1_uc010tlf.1_RNA|TEP1_uc010tlg.1_Missense_Mutation_p.G983W|TEP1_uc010tlh.1_5'Flank	NM_007110	NP_009041	Q99973	TEP1_HUMAN	telomerase-associated protein 1	1091					telomere maintenance via recombination	chromosome, telomeric region|cytoplasm|nuclear matrix|soluble fraction|telomerase holoenzyme complex	ATP binding|RNA binding			ovary(5)	5	all_cancers(95;0.00123)	all_lung(585;0.235)	Epithelial(56;7.42e-08)|all cancers(55;6.46e-07)	GBM - Glioblastoma multiforme(265;0.028)|READ - Rectum adenocarcinoma(17;0.233)		TCCTCCAGCCCGCCAACATAG	0.592			NA											8	237					0.00621372	0.00658168	0.006214	1	0
RNASE11	122651	broad.mit.edu	37	14	21052309	21052309	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr14:21052309C>G	uc010ahv.2	-	2	510	c.325G>C	c.(325-327)GAA>CAA	p.E109Q	RNASE11_uc010ahx.2_Missense_Mutation_p.E109Q|RNASE11_uc010ahw.2_Missense_Mutation_p.E109Q|RNASE11_uc001vxs.2_Missense_Mutation_p.E109Q	NM_145250	NP_660293	Q8TAA1	RNS11_HUMAN	ribonuclease, RNase A family, 11 (non-active)	109						extracellular region	nucleic acid binding|pancreatic ribonuclease activity			ovary(3)	3	all_cancers(95;0.00238)	all_lung(585;0.235)	Epithelial(56;1.85e-06)|all cancers(55;1.46e-05)	GBM - Glioblastoma multiforme(265;0.0139)		CCGTTTGCTTCTGAAACTTTT	0.468			NA											24	149					0	0	0.00278	0	0
RNASE11	122651	broad.mit.edu	37	14	21052324	21052324	+	Missense_Mutation	SNP	A	A	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr14:21052324A>T	uc010ahv.2	-	2	495	c.310T>A	c.(310-312)TGG>AGG	p.W104R	RNASE11_uc010ahx.2_Missense_Mutation_p.W104R|RNASE11_uc010ahw.2_Missense_Mutation_p.W104R|RNASE11_uc001vxs.2_Missense_Mutation_p.W104R	NM_145250	NP_660293	Q8TAA1	RNS11_HUMAN	ribonuclease, RNase A family, 11 (non-active)	104						extracellular region	nucleic acid binding|pancreatic ribonuclease activity			ovary(3)	3	all_cancers(95;0.00238)	all_lung(585;0.235)	Epithelial(56;1.85e-06)|all cancers(55;1.46e-05)	GBM - Glioblastoma multiforme(265;0.0139)		ACTTTTCTCCAGACTGTCATG	0.468			NA											29	177					0	0	0.009535	0	0
Unknown	0	broad.mit.edu	37	14	23019583	23019583	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr14:23019583G>T	uc001wbw.2	+	6	816	c.807G>T	c.(805-807)ATG>ATT	p.M269I	uc001wcx.3_RNA|uc001wdv.3_Missense_Mutation_p.M195I|uc001wec.2_Missense_Mutation_p.M154I|uc001wee.3_Missense_Mutation_p.M83I|uc001weg.2_Missense_Mutation_p.M83I|uc001wei.2_Missense_Mutation_p.M83I|uc001wej.2_Missense_Mutation_p.M83I|uc001wek.2_Missense_Mutation_p.M140I|uc001wel.2_Missense_Mutation_p.M83I|uc001wem.3_Missense_Mutation_p.M83I|uc001weo.2_Missense_Mutation_p.M83I|uc001wep.2_Missense_Mutation_p.M83I|uc001weq.2_Missense_Mutation_p.M147I|uc001wer.2_RNA|uc001wet.2_Missense_Mutation_p.M83I|uc001weu.2_Missense_Mutation_p.M83I|uc001wev.2_Missense_Mutation_p.M148I|uc001wew.2_Missense_Mutation_p.M83I|uc010ajx.1_Missense_Mutation_p.M83I|uc001wfd.1_Missense_Mutation_p.M83I|uc001wfe.2_Missense_Mutation_p.M155I|uc001wfh.1_Missense_Mutation_p.M146I|uc001wfk.2_Missense_Mutation_p.M83I|uc010ajy.1_Missense_Mutation_p.M83I|uc001wfn.2_Missense_Mutation_p.M83I|uc001wfp.2_Missense_Mutation_p.M83I|uc001wfw.1_Missense_Mutation_p.M83I|uc001wfx.2_Missense_Mutation_p.M83I|uc001wgd.2_Missense_Mutation_p.M140I|uc001wge.3_Missense_Mutation_p.M83I|uc010tmw.1_Missense_Mutation_p.M83I|uc010tmx.1_Missense_Mutation_p.M83I|uc001wgh.2_Missense_Mutation_p.M83I|uc001wgj.1_Missense_Mutation_p.M83I|uc001wgk.2_Missense_Mutation_p.M83I					SubName: Full=Alpha-chain C region; Flags: Fragment;												NA						ATCTGCTCATGACGCTGCGGC	0.542			NA											4	66					0.00024832	0.000278259	0.009096	1	0
CEBPE	1053	broad.mit.edu	37	14	23586879	23586879	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr14:23586879G>T	uc001wiv.1	-	2	837	c.663C>A	c.(661-663)AGC>AGA	p.S221R		NM_001805	NP_001796	Q15744	CEBPE_HUMAN	CCAAT/enhancer binding protein epsilon	221	Basic motif.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(2)	2	all_cancers(95;4.6e-05)			GBM - Glioblastoma multiforme(265;0.0064)		CCTTGTCTCGGCTCTTGCGCA	0.627	NSCLC(63;1230 1818 14565 22565)		NA											14	69					4.93089e-13	7.0933e-13	0.00245	1	0
MYH7	4625	broad.mit.edu	37	14	23900116	23900116	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr14:23900116G>T	uc001wjx.2	-	10	995	c.889C>A	c.(889-891)CTG>ATG	p.L297M		NM_000257	NP_000248	P12883	MYH7_HUMAN	myosin, heavy chain 7, cardiac muscle, beta	297	Myosin head-like.				adult heart development|muscle filament sliding|regulation of heart rate|ventricular cardiac muscle tissue morphogenesis	focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(3)|skin(1)	4	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00725)		TCACCCAGCAGCTCAGGCTTT	0.488			NA											31	199					3.57733e-08	4.54599e-08	0.009535	1	0
FSCB	84075	broad.mit.edu	37	14	44974853	44974853	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr14:44974853C>T	uc001wvn.2	-	1	1647	c.1338G>A	c.(1336-1338)ATG>ATA	p.M446I		NM_032135	NP_115511	Q5H9T9	FSCB_HUMAN	fibrous sheath CABYR binding protein	446						cilium				lung(3)|breast(3)|ovary(2)|central_nervous_system(1)	9				GBM - Glioblastoma multiforme(112;0.128)		CAGGGGTCTCCATAGCTGTTG	0.493			NA											13	25					0	0	0.001855	0	0
C14orf37	145407	broad.mit.edu	37	14	58604955	58604955	+	Silent	SNP	T	T	G			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr14:58604955T>G	uc001xdc.2	-	2	1233	c.1122A>C	c.(1120-1122)ACA>ACC	p.T374T	C14orf37_uc010tro.1_Silent_p.T412T|C14orf37_uc001xdd.2_Silent_p.T374T|C14orf37_uc001xde.2_Silent_p.T374T	NM_001001872	NP_001001872	Q86TY3	CN037_HUMAN	hypothetical protein LOC145407 precursor	374	Extracellular (Potential).					integral to membrane	binding				0						TGCCCGTGTGTGTTTCCCCTT	0.537			NA											7	235					0	0	0.00308	0	0
TOMM20L	387990	broad.mit.edu	37	14	58869474	58869474	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr14:58869474C>A	uc001xdr.1	+	3	289	c.257C>A	c.(256-258)TCT>TAT	p.S86Y	TOMM20L_uc010trq.1_Intron	NM_207377	NP_997260	Q6UXN7	TO20L_HUMAN	translocase of outer mitochondrial membrane 20	86	Cytoplasmic (Potential).				protein targeting	integral to membrane|mitochondrial outer membrane translocase complex					0						CTTTGGTTATCTAGAGGTAAG	0.308			NA											21	113					4.26978e-12	6.00556e-12	0.00333	1	0
PLEKHH1	57475	broad.mit.edu	37	14	68042641	68042641	+	Silent	SNP	G	G	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr14:68042641G>A	uc001xjl.1	+	16	2413	c.2271G>A	c.(2269-2271)TTG>TTA	p.L757L	PLEKHH1_uc010tsw.1_Silent_p.L325L|PLEKHH1_uc001xjn.1_Silent_p.L272L|PLEKHH1_uc010tsx.1_5'Flank	NM_020715	NP_065766	Q9ULM0	PKHH1_HUMAN	pleckstrin homology domain containing, family H	757	PH 2.					cytoskeleton	binding				0				all cancers(60;0.000771)|OV - Ovarian serous cystadenocarcinoma(108;0.00502)|BRCA - Breast invasive adenocarcinoma(234;0.011)		CCAGACGGTTGCTTTCCTCCC	0.592			NA											4	36					0	0	0.009096	0	0
EIF2B2	8892	broad.mit.edu	37	14	75469819	75469819	+	Silent	SNP	G	G	C			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr14:75469819G>C	uc001xrc.1	+	1	208	c.126G>C	c.(124-126)CTG>CTC	p.L42L		NM_014239	NP_055054	P49770	EI2BB_HUMAN	eukaryotic translation initiation factor 2B,	42					cellular response to stimulus|myelination|oligodendrocyte development|ovarian follicle development|regulation of translational initiation|response to glucose stimulus|response to heat|response to peptide hormone stimulus	cytosol|eukaryotic translation initiation factor 2B complex	ATP binding|GTP binding|protein binding|translation initiation factor activity			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(234;0.00661)		TAGGGTTGCTGCGCCAGATCA	0.672			NA											4	37					0	0	0.000602	0	0
C14orf49	161176	broad.mit.edu	37	14	95906001	95906001	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr14:95906001C>G	uc001yei.3	-	12	2209	c.2194G>C	c.(2194-2196)GAG>CAG	p.E732Q	C14orf49_uc010avi.2_Missense_Mutation_p.E732Q	NM_152592	NP_689805	Q6ZMZ3	SYNE3_HUMAN	nesprin-3	732	Spectrin 2.|Cytoplasmic (Potential).				cytoskeletal anchoring at nuclear membrane	integral to membrane|nuclear outer membrane|SUN-KASH complex	actin binding			central_nervous_system(1)	1		all_cancers(154;0.0937)		COAD - Colon adenocarcinoma(157;0.245)		TCTGCCAGCTCCCTGAGCTCC	0.637			NA											14	47					0	0	0.00499	0	0
AK7	122481	broad.mit.edu	37	14	96922763	96922763	+	Missense_Mutation	SNP	T	T	C			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr14:96922763T>C	uc001yfn.2	+	11	1222	c.1178T>C	c.(1177-1179)CTG>CCG	p.L393P		NM_152327	NP_689540	Q96M32	KAD7_HUMAN	adenylate kinase 7	393	Adenylate kinase.|Potential.				cell projection organization	cytosol	adenylate kinase activity|ATP binding|cytidylate kinase activity			ovary(1)	1		all_cancers(154;0.0482)|all_epithelial(191;0.128)|Melanoma(154;0.155)		Epithelial(152;0.134)|COAD - Colon adenocarcinoma(157;0.228)		TACTACAAACTGCATCACATC	0.393			NA											17	114					0	0	0.00499	0	0
C14orf177	283598	broad.mit.edu	37	14	99183529	99183529	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr14:99183529C>G	uc001yfz.1	+	4	715	c.296C>G	c.(295-297)GCT>GGT	p.A99G		NM_182560	NP_872366	Q52M58	CN177_HUMAN	hypothetical protein LOC283598	99											0		Melanoma(154;0.128)				ATAATGTCTGCTTCGACCATC	0.413			NA											10	74					0	0	0.006214	0	0
RAGE	5891	broad.mit.edu	37	14	102718263	102718263	+	Missense_Mutation	SNP	T	T	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr14:102718263T>A	uc001ylm.2	-	5	579	c.353A>T	c.(352-354)CAT>CTT	p.H118L	RAGE_uc010txv.1_Missense_Mutation_p.H88L|RAGE_uc001yln.2_5'UTR	NM_014226	NP_055041	Q9UQ07	MOK_HUMAN	MAPK/MAK/MRK overlapping kinase	118	Protein kinase.				signal transduction	Golgi apparatus	ATP binding|cyclin-dependent protein kinase activity|protein binding			ovary(2)|breast(1)|central_nervous_system(1)	4						CCTGTGAATATGATCCAGGGA	0.323			NA											20	59					0	0	0.00278	0	0
AHNAK2	113146	broad.mit.edu	37	14	105416752	105416752	+	Missense_Mutation	SNP	G	G	T	rs11852054		TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr14:105416752G>T	uc010axc.1	-	7	5156	c.5036C>A	c.(5035-5037)GCC>GAC	p.A1679D	AHNAK2_uc001ypx.2_Missense_Mutation_p.A1579D	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	1679						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			ATCCACCGAGGCCTCGATGGA	0.582			NA											5	144					0.00448238	0.00477449	0.004482	1	0
PACS2	23241	broad.mit.edu	37	14	105818726	105818726	+	Silent	SNP	A	A	G			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr14:105818726A>G	uc001yqt.2	+	3	394	c.219A>G	c.(217-219)CGA>CGG	p.R73R	PACS2_uc001yqs.2_Silent_p.R6R|PACS2_uc001yqv.2_Silent_p.R73R|PACS2_uc001yqu.2_Silent_p.R73R	NM_015197	NP_056012	Q86VP3	PACS2_HUMAN	phosphofurin acidic cluster sorting protein 2	73					apoptosis|interspecies interaction between organisms	endoplasmic reticulum lumen|mitochondrion				pancreas(1)	1		all_cancers(154;0.0351)|all_epithelial(191;0.153)|Melanoma(154;0.155)	OV - Ovarian serous cystadenocarcinoma(23;0.0145)|Epithelial(46;0.036)	Epithelial(152;0.138)		GCTCCAAACGAATCCTGCGGT	0.532			NA									OREG0022968	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	19	221					0	0	0.006122	0	0
GABRG3	2567	broad.mit.edu	37	15	27777780	27777780	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr15:27777780C>T	uc001zbg.1	+	10	1323	c.1157C>T	c.(1156-1158)ACT>ATT	p.T386I		NM_033223	NP_150092	Q99928	GBRG3_HUMAN	gamma-aminobutyric acid (GABA) A receptor, gamma	386	Cytoplasmic (Probable).			T -> P (in Ref. 1; AAB39369).	gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity				0		all_lung(180;4.58e-12)|Breast(32;0.000625)|Colorectal(260;0.235)		all cancers(64;3.15e-07)|Epithelial(43;1.17e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0261)		CCACCACCAACTGCGATGATC	0.428	NSCLC(114;800 1656 7410 37729 45293)		NA											7	32					0	0	0.001984	0	0
APBA2	321	broad.mit.edu	37	15	29346679	29346679	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr15:29346679C>A	uc001zck.2	+	3	799	c.592C>A	c.(592-594)CCC>ACC	p.P198T	APBA2_uc010azj.2_Missense_Mutation_p.P198T|APBA2_uc010uat.1_Missense_Mutation_p.P198T|APBA2_uc001zcl.2_Missense_Mutation_p.P198T|APBA2_uc010uas.1_Missense_Mutation_p.P198T	NM_005503	NP_005494	Q99767	APBA2_HUMAN	amyloid beta A4 precursor protein-binding,	198	STXBP1-binding.			DEPSVLEAHDQEEDGHYCASKEGYQDYYPEEANGNTGASPY RLRR -> MSPPSLRPMTRKKMVTMCQQRGLPGLLPRGGQR EHRRLPLPPEA (in Ref. 1; AAC39767).	nervous system development|protein transport		protein binding				0		all_lung(180;1.73e-12)|Breast(32;2.89e-05)|Colorectal(260;0.234)		all cancers(64;7.44e-11)|Epithelial(43;5.74e-10)|GBM - Glioblastoma multiforme(186;0.026)|BRCA - Breast invasive adenocarcinoma(123;0.0286)|Lung(196;0.24)		GGACTACTACCCCGAGGAGGC	0.632			NA											10	23					4.68919e-08	5.93505e-08	0.008291	1	0
SPG11	80208	broad.mit.edu	37	15	44905680	44905680	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr15:44905680G>C	uc001ztx.2	-	17	3124	c.3093C>G	c.(3091-3093)CAC>CAG	p.H1031Q	SPG11_uc010ueh.1_Missense_Mutation_p.H1031Q|SPG11_uc010uei.1_Missense_Mutation_p.H1031Q	NM_025137	NP_079413	Q96JI7	SPTCS_HUMAN	spatacsin isoform 1	1031	Extracellular (Potential).				cell death	cytosol|integral to membrane|nucleus	protein binding			ovary(4)|skin(1)	5		all_cancers(109;1.29e-14)|all_epithelial(112;1.26e-12)|Lung NSC(122;1.34e-07)|all_lung(180;1.21e-06)|Melanoma(134;0.0122)		all cancers(107;2.93e-22)|GBM - Glioblastoma multiforme(94;1.55e-06)|COAD - Colon adenocarcinoma(120;0.0432)|Colorectal(105;0.0484)|Lung(196;0.104)|LUSC - Lung squamous cell carcinoma(244;0.214)		CAAACCAAGGGTGTGCTTCAT	0.343			NA											11	52					0	0	0.000978	0	0
GATM	2628	broad.mit.edu	37	15	45660383	45660383	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr15:45660383C>A	uc001zvc.2	-	4	889	c.560G>T	c.(559-561)CGT>CTT	p.R187L	GATM_uc001zvb.2_Missense_Mutation_p.R58L|GATM_uc010uev.1_Missense_Mutation_p.R240L	NM_001482	NP_001473	P50440	GATM_HUMAN	L-arginine:glycine amidinotransferase precursor	187					creatine biosynthetic process	mitochondrial inner membrane|mitochondrial intermembrane space	glycine amidinotransferase activity|protein binding				0		all_cancers(109;1.25e-09)|all_epithelial(112;5.56e-08)|Lung NSC(122;3.55e-06)|all_lung(180;2.56e-05)|Melanoma(134;0.027)		all cancers(107;4.87e-16)|GBM - Glioblastoma multiforme(94;1.97e-06)	Creatine(DB00148)|Glycine(DB00145)|L-Ornithine(DB00129)	GAAGCGTGAACGCCATGCCAT	0.488			NA											9	29					1.58986e-06	1.91511e-06	0.008291	1	0
SEMA6D	80031	broad.mit.edu	37	15	48057206	48057206	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr15:48057206G>T	uc010bek.2	+	13	1740	c.1380G>T	c.(1378-1380)TTG>TTT	p.L460F	SEMA6D_uc001zvw.2_Missense_Mutation_p.L460F|SEMA6D_uc001zvx.1_Missense_Mutation_p.L460F|SEMA6D_uc001zvy.2_Missense_Mutation_p.L460F|SEMA6D_uc001zvz.2_Missense_Mutation_p.L460F|SEMA6D_uc001zwa.2_Missense_Mutation_p.L460F|SEMA6D_uc001zwb.2_Missense_Mutation_p.L460F|SEMA6D_uc001zwc.2_Missense_Mutation_p.L460F	NM_153618	NP_705871	Q8NFY4	SEM6D_HUMAN	semaphorin 6D isoform 4 precursor	460	Sema.|Extracellular (Potential).				axon guidance	cytoplasm|integral to membrane|plasma membrane	receptor activity			skin(3)|breast(1)	4		all_lung(180;0.000635)|Myeloproliferative disorder(241;0.116)|Melanoma(134;0.18)		all cancers(107;1.2e-11)|GBM - Glioblastoma multiforme(94;1.2e-06)		CTTTCTCTTTGAACGACAGCG	0.453			NA											5	103					2.7689e-08	3.53762e-08	0.001984	1	0
SLC24A5	283652	broad.mit.edu	37	15	48413344	48413344	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr15:48413344C>A	uc001zwe.2	+	1	176	c.103C>A	c.(103-105)CGT>AGT	p.R35S	SLC24A5_uc001zwd.2_Missense_Mutation_p.R35S|SLC24A5_uc010bel.2_Missense_Mutation_p.R35S	NM_205850	NP_995322	Q71RS6	NCKX5_HUMAN	solute carrier family 24, member 5 precursor	35	Extracellular (Potential).				response to stimulus	integral to membrane|melanosome|plasma membrane	calcium, potassium:sodium antiporter activity|symporter activity				0		all_lung(180;0.00217)		all cancers(107;3.29e-10)|GBM - Glioblastoma multiforme(94;7.32e-07)		CCTGCCCCAACGTCTCCCAAG	0.587			NA											6	14					2.0095e-06	2.40531e-06	0.001984	1	0
SLC12A1	6557	broad.mit.edu	37	15	48537080	48537080	+	Nonsense_Mutation	SNP	C	C	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr15:48537080C>A	uc001zwn.3	+	11	1647	c.1431C>A	c.(1429-1431)TAC>TAA	p.Y477*	SLC12A1_uc010uew.1_Nonsense_Mutation_p.Y283*|SLC12A1_uc010bem.2_Nonsense_Mutation_p.Y477*|SLC12A1_uc001zwq.3_Nonsense_Mutation_p.Y248*|SLC12A1_uc001zwr.3_Nonsense_Mutation_p.Y204*	NM_000338	NP_000329	Q13621	S12A1_HUMAN	sodium potassium chloride cotransporter 2	477					potassium ion transport|sodium ion transport	integral to membrane|membrane fraction	sodium:potassium:chloride symporter activity			ovary(1)|central_nervous_system(1)	2		all_lung(180;0.00219)		all cancers(107;1.76e-09)|GBM - Glioblastoma multiforme(94;1.48e-06)	Bumetanide(DB00887)|Chlormerodrin(DB00534)|Chlorthalidone(DB00310)|Ethacrynic acid(DB00903)|Furosemide(DB00695)|Hydroflumethiazide(DB00774)|Methyclothiazide(DB00232)|Metolazone(DB00524)|Potassium Chloride(DB00761)|Torasemide(DB00214)|Trichlormethiazide(DB01021)	CATGTCAGTACGGGCTGATGA	0.383			NA											17	45					1.02788e-11	1.44361e-11	0.00499	1	0
SECISBP2L	9728	broad.mit.edu	37	15	49284799	49284799	+	Missense_Mutation	SNP	A	A	C			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr15:49284799A>C	uc001zxe.1	-	18	3082	c.2948T>G	c.(2947-2949)CTT>CGT	p.L983R	SECISBP2L_uc001zxd.1_Missense_Mutation_p.L938R	NM_014701	NP_055516	Q93073	SBP2L_HUMAN	SECIS binding protein 2-like	983										breast(1)|skin(1)	2						GCCAGGTACAAGAGTGCTGGT	0.393			NA											4	97					0	0	0.000602	0	0
SECISBP2L	9728	broad.mit.edu	37	15	49327723	49327723	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr15:49327723C>A	uc001zxe.1	-	3	470	c.336G>T	c.(334-336)ATG>ATT	p.M112I	SECISBP2L_uc001zxd.1_Missense_Mutation_p.M112I|SECISBP2L_uc010bep.1_Intron|SECISBP2L_uc010beq.1_Missense_Mutation_p.M112I	NM_014701	NP_055516	Q93073	SBP2L_HUMAN	SECIS binding protein 2-like	112										breast(1)|skin(1)	2						ATGGTGCTGGCATCAGCTGAT	0.453			NA											7	187					0.00307968	0.00329147	0.00308	1	0
SLC27A2	11001	broad.mit.edu	37	15	50519376	50519376	+	Splice_Site	SNP	G	G	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr15:50519376G>A	uc001zxw.2	+	7	1689	c.1457_splice	c.e7+1	p.R486_splice	SLC27A2_uc010bes.2_Splice_Site_p.R433_splice|SLC27A2_uc001zxx.2_Splice_Site_p.R251_splice	NM_003645	NP_003636	O14975	S27A2_HUMAN	solute carrier family 27 (fatty acid						bile acid biosynthetic process|fatty acid alpha-oxidation	endoplasmic reticulum membrane|integral to membrane|peroxisomal matrix|peroxisomal membrane	ATP binding|long-chain fatty acid-CoA ligase activity|phytanate-CoA ligase activity|pristanate-CoA ligase activity			ovary(1)|skin(1)	2		all_lung(180;0.00177)		all cancers(107;1.16e-06)|GBM - Glioblastoma multiforme(94;0.000113)		ATACATTCCGGTTGGTTTTTC	0.398			NA											5	94					0	0	0.001168	0	0
WDR72	256764	broad.mit.edu	37	15	54003555	54003555	+	Missense_Mutation	SNP	A	A	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr15:54003555A>T	uc002acj.2	-	8	877	c.835T>A	c.(835-837)TAC>AAC	p.Y279N	WDR72_uc010bfi.1_Missense_Mutation_p.Y279N	NM_182758	NP_877435	Q3MJ13	WDR72_HUMAN	WD repeat domain 72	279										lung(1)|skin(1)	2				all cancers(107;0.0511)		TGATAGATGTAACTGTGACCA	0.448			NA											15	94					0	0	0.00499	0	0
TBC1D21	161514	broad.mit.edu	37	15	74178875	74178875	+	Silent	SNP	G	G	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr15:74178875G>T	uc002avz.2	+	8	782	c.699G>T	c.(697-699)GTG>GTT	p.V233V	TBC1D21_uc010ulc.1_Silent_p.V197V	NM_153356	NP_699187	Q8IYX1	TBC21_HUMAN	TBC1 domain family, member 21	233	Rab-GAP TBC.					intracellular	Rab GTPase activator activity			ovary(2)	2						CAGGGGCTGTGCAGTCCCTCT	0.562			NA											7	42					0.000157383	0.000176986	0.00308	1	0
SCAMP5	192683	broad.mit.edu	37	15	75310808	75310808	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr15:75310808G>T	uc002azk.1	+	6	607	c.445G>T	c.(445-447)GTG>TTG	p.V149L	SCAMP5_uc002azl.1_Missense_Mutation_p.V149L|SCAMP5_uc002azm.1_Missense_Mutation_p.V149L|SCAMP5_uc002azn.1_Missense_Mutation_p.V157L|SCAMP5_uc010uly.1_Missense_Mutation_p.V78L	NM_138967	NP_620417	Q8TAC9	SCAM5_HUMAN	secretory carrier membrane protein 5	149	Helical; (Potential).				exocytosis|negative regulation of endocytosis|positive regulation of calcium ion-dependent exocytosis|positive regulation of cytokine secretion|protein transport|response to endoplasmic reticulum stress	cell junction|integral to membrane|recycling endosome membrane|synaptic vesicle membrane|trans-Golgi network membrane	protein binding			ovary(1)	1						TGGCTCGGCGGTGGTGATGCT	0.582			NA											13	106					9.31168e-06	1.09522e-05	0.001855	1	0
CSPG4	1464	broad.mit.edu	37	15	75982722	75982722	+	Missense_Mutation	SNP	A	A	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr15:75982722A>T	uc002baw.2	-	3	777	c.684T>A	c.(682-684)TTT>TTA	p.F228L		NM_001897	NP_001888	Q6UVK1	CSPG4_HUMAN	chondroitin sulfate proteoglycan 4 precursor	228	Extracellular (Potential).|Neurite growth inhibition (By similarity).|Globular or compact configuration stabilized by disulfide bonds.|Laminin G-like 2.				angiogenesis|cell differentiation|intracellular signal transduction|positive regulation of peptidyl-tyrosine phosphorylation|tissue remodeling	apical plasma membrane|cell surface|integral to plasma membrane|intracellular|lamellipodium membrane	protein kinase binding|signal transducer activity			ovary(2)|pancreas(1)	3						TGGTGAGTGTAAACTCTAGGG	0.617			NA											23	36					0	0	0.003954	0	0
PGPEP1L	145814	broad.mit.edu	37	15	99512842	99512843	+	Missense_Mutation	DNP	CG	CG	AA			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	CG	CG	-	-	CG	CG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr15:99512842_99512843CG>AA	uc002bum.2	-	4	388_389	c.182_183CG>TT	c.(181-183)GCG>GTT	p.A61V	PGPEP1L_uc010bop.2_Missense_Mutation_p.A7V|PGPEP1L_uc002bun.2_RNA	NM_001102612	NP_001096082	A6NFU8	PGPIL_HUMAN	pyroglutamyl-peptidase 1-like protein	61					proteolysis		cysteine-type peptidase activity				0						CCAGAATGATCGCCTTGGCGGC	0.624			NA											18	101					0	0	0.004672	0	0
LASS3	204219	broad.mit.edu	37	15	100942989	100942989	+	Nonsense_Mutation	SNP	C	C	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr15:100942989C>A	uc002bvz.2	-	13	1583	c.1081G>T	c.(1081-1083)GAG>TAG	p.E361*	LASS3_uc002bwa.2_Nonsense_Mutation_p.E372*|LASS3_uc002bwb.2_Nonsense_Mutation_p.E361*	NM_178842	NP_849164	Q8IU89	CERS3_HUMAN	LAG1 longevity assurance homolog 3	361						endoplasmic reticulum membrane|integral to membrane|nuclear membrane	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|sphingosine N-acyltransferase activity			ovary(2)|pancreas(1)|skin(1)	4	Lung NSC(78;0.0018)|all_lung(78;0.00278)|Melanoma(26;0.00852)		OV - Ovarian serous cystadenocarcinoma(32;0.000867)|LUSC - Lung squamous cell carcinoma(107;0.132)|Lung(145;0.161)			CAATCCATCTCTTTGCCTTTG	0.418	NSCLC(135;1149 2482 10680 49908)		NA											6	40					5.9392e-07	7.23697e-07	0.001168	1	0
TPSAB1	7177	broad.mit.edu	37	16	1291632	1291632	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr16:1291632C>A	uc002ckz.2	+	4	483	c.431C>A	c.(430-432)CCT>CAT	p.P144H	TPSAB1_uc010uux.1_Missense_Mutation_p.P80H	NM_003294	NP_003285	Q15661	TRYB1_HUMAN	tryptase alpha/beta 1 precursor	144	Peptidase S1.				defense response|proteolysis	extracellular space	protein binding|serine-type endopeptidase activity				0		Hepatocellular(780;0.00369)				ACCCTGCCCCCTGCCTCAGAG	0.672			NA											3	12					0.00116845	0.00127467	0.001168	1	0
ALG1	56052	broad.mit.edu	37	16	5129756	5129756	+	Silent	SNP	A	A	G			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr16:5129756A>G	uc002cym.2	+	9	950	c.909A>G	c.(907-909)GAA>GAG	p.E303E	ALG1_uc002cyj.2_Silent_p.E192E|ALG1_uc002cyn.2_Silent_p.E303E|ALG1_uc010bue.2_Silent_p.E192E|ALG1_uc010uxy.1_Silent_p.E192E	NM_019109	NP_061982	Q9BT22	ALG1_HUMAN	beta-1,4-mannosyltransferase	303	Lumenal (Potential).				dolichol-linked oligosaccharide biosynthetic process|lipopolysaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane|integral to membrane	chitobiosyldiphosphodolichol beta-mannosyltransferase activity			upper_aerodigestive_tract(1)|ovary(1)	2		Ovarian(90;0.0164)				CAGAGTTTGAACAACTGACTC	0.348			NA											3	138					0	0	0.001984	0	0
NOMO1	23420	broad.mit.edu	37	16	14989374	14989374	+	Missense_Mutation	SNP	A	A	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr16:14989374A>T	uc002dcv.2	+	31	3607	c.3541A>T	c.(3541-3543)ATT>TTT	p.I1181F		NM_014287	NP_055102	Q15155	NOMO1_HUMAN	nodal modulator 1 precursor	1181	Cytoplasmic (Potential).					integral to membrane	carbohydrate binding|carboxypeptidase activity|protein binding			ovary(1)	1						TTTCTAGCTCATTCCTTTGCT	0.542			NA											72	233					0	0	0.00361	0	0
XYLT1	64131	broad.mit.edu	37	16	17353089	17353089	+	Silent	SNP	G	G	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr16:17353089G>T	uc002dfa.2	-	3	754	c.669C>A	c.(667-669)GCC>GCA	p.A223A		NM_022166	NP_071449	Q86Y38	XYLT1_HUMAN	xylosyltransferase I	223	Lumenal (Potential).				glycosaminoglycan biosynthetic process	endoplasmic reticulum membrane|extracellular region|Golgi membrane|integral to membrane	acetylglucosaminyltransferase activity|protein xylosyltransferase activity			ovary(4)	4						TGTTGGCTGCGGCTCTGTCCC	0.592			NA											34	165					3.62531e-18	5.4726e-18	0.004289	1	0
SMG1	23049	broad.mit.edu	37	16	18882704	18882704	+	Missense_Mutation	SNP	T	T	C			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr16:18882704T>C	uc002dfm.2	-	16	2647	c.2284A>G	c.(2284-2286)AAA>GAA	p.K762E	SMG1_uc010bwb.2_Missense_Mutation_p.K622E	NM_015092	NP_055907	Q96Q15	SMG1_HUMAN	PI-3-kinase-related kinase SMG-1	762	Interaction with SMG8 and SMG9.				DNA repair|mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|peptidyl-serine phosphorylation|phosphatidylinositol phosphorylation|protein autophosphorylation	cytoplasm|nucleus	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			breast(5)|stomach(4)|lung(4)|kidney(2)|ovary(1)	16						AAAAGGCCTTTGCAAAATTTA	0.348			NA											10	19					0	0	0.008291	0	0
SLC5A11	115584	broad.mit.edu	37	16	24909338	24909338	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr16:24909338C>A	uc002dmu.2	+	10	1146	c.914C>A	c.(913-915)GCC>GAC	p.A305D	SLC5A11_uc002dms.2_Missense_Mutation_p.A241D|SLC5A11_uc010vcd.1_Missense_Mutation_p.A270D|SLC5A11_uc002dmt.2_Nonsense_Mutation_p.C172*|SLC5A11_uc010vce.1_Missense_Mutation_p.A235D|SLC5A11_uc010bxt.2_Missense_Mutation_p.A241D	NM_052944	NP_443176	Q8WWX8	SC5AB_HUMAN	solute carrier family 5 (sodium/glucose	305	Cytoplasmic (Potential).				apoptosis|carbohydrate transport|sodium ion transport	integral to membrane|plasma membrane	polyol transmembrane transporter activity|symporter activity			ovary(2)	2				GBM - Glioblastoma multiforme(48;0.0365)		CTGTCCCATGCCAAAGGAGGT	0.498			NA											12	285					0.00185496	0.00201663	0.001855	1	0
CLN3	1201	broad.mit.edu	37	16	28488912	28488912	+	Silent	SNP	G	G	T	rs1064886		TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr16:28488912G>T	uc002dpo.2	-	15	1565	c.1242C>A	c.(1240-1242)ATC>ATA	p.I414I	uc010vct.1_Intron|CLN3_uc002dpl.2_Silent_p.I336I|CLN3_uc010vcu.1_Silent_p.I314I|CLN3_uc002dpn.2_Silent_p.I315I|CLN3_uc002dpm.2_Silent_p.I360I|CLN3_uc010vcv.1_Silent_p.I390I|CLN3_uc010byd.2_Silent_p.I317I|CLN3_uc002dpp.2_Silent_p.I414I|CLN3_uc002dpt.1_Silent_p.I314I|CLN3_uc002dpq.1_Silent_p.I366I|CLN3_uc010bye.1_Silent_p.I397I|CLN3_uc002dpr.1_RNA|CLN3_uc010byf.1_RNA|CLN3_uc002dps.1_Silent_p.I287I|CLN3_uc002dpu.1_Silent_p.I312I	NM_000086	NP_000077	Q13286	CLN3_HUMAN	ceroid-lipofuscinosis, neuronal 3	414	Helical; (Potential).				amyloid precursor protein catabolic process|arginine transport|associative learning|autophagic vacuole fusion|cell death|cellular amino acid metabolic process|cytosolic calcium ion homeostasis|galactosylceramide metabolic process|globoside metabolic process|glucosylceramide metabolic process|ionotropic glutamate receptor signaling pathway|lysosomal lumen acidification|lysosomal lumen pH elevation|negative regulation of catalytic activity|negative regulation of macroautophagy|negative regulation of neuron apoptosis|negative regulation of proteolysis|neuromuscular process controlling balance|neurotransmitter metabolic process|protein catabolic process|protein folding|protein processing|receptor-mediated endocytosis|regulation of action potential|sphingomyelin metabolic process|vacuolar transport	autophagic vacuole|caveola|cytosol|early endosome|Golgi membrane|Golgi stack|integral to endoplasmic reticulum membrane|late endosome|lysosomal membrane|membrane fraction|mitochondrion|neuron projection|nucleus|synaptic vesicle|trans-Golgi network	unfolded protein binding				0						GTGTGTCAGAGATGCAGGTGG	0.617			NA											35	70					1.07121e-22	1.69817e-22	0.006999	1	0
FAM57B	83723	broad.mit.edu	37	16	30041747	30041747	+	Silent	SNP	G	G	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr16:30041747G>A	uc002dvt.2	-	1	440	c.102C>T	c.(100-102)GCC>GCT	p.A34A	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|FAM57B_uc002dvu.2_5'Flank	NM_031478	NP_113666	Q71RH2	FA57B_HUMAN	hypothetical protein LOC83723	34	TLC.					endoplasmic reticulum|integral to membrane					0						TGACTGCGTCGGCCTCCTCCC	0.622			NA											5	37					0	0	0.000602	0	0
LONP2	83752	broad.mit.edu	37	16	48304127	48304127	+	Nonsense_Mutation	SNP	G	G	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr16:48304127G>T	uc002efi.1	+	7	1272	c.1183G>T	c.(1183-1185)GAG>TAG	p.E395*	LONP2_uc010vgm.1_RNA|LONP2_uc002efj.1_Nonsense_Mutation_p.E351*	NM_031490	NP_113678	Q86WA8	LONP2_HUMAN	peroxisomal LON protease-like	395					misfolded or incompletely synthesized protein catabolic process|protein targeting to peroxisome|signal peptide processing	nucleoid|peroxisomal matrix	ATP binding|ATP-dependent peptidase activity|enzyme binding|sequence-specific DNA binding|serine-type endopeptidase activity				0						TCTAGGTCGAGAGTTCCACAG	0.463			NA											29	151					7.01153e-11	9.6753e-11	0.007291	1	0
SALL1	6299	broad.mit.edu	37	16	51174718	51174718	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr16:51174718G>T	uc010vgs.1	-	2	1446	c.1415C>A	c.(1414-1416)ACC>AAC	p.T472N	SALL1_uc010vgr.1_Missense_Mutation_p.T375N|SALL1_uc010cbv.2_Intron	NM_002968	NP_002959	Q9NSC2	SALL1_HUMAN	sal-like 1 isoform a	472					adrenal gland development|branching involved in ureteric bud morphogenesis|embryonic digestive tract development|embryonic digit morphogenesis|gonad development|histone deacetylation|inductive cell-cell signaling|mesenchymal to epithelial transition involved in metanephros morphogenesis|negative regulation of transcription from RNA polymerase II promoter|olfactory bulb interneuron differentiation|olfactory bulb mitral cell layer development|olfactory nerve development|outer ear morphogenesis|pituitary gland development|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway|ureteric bud invasion|ventricular septum development	chromocenter|cytoplasm|heterochromatin|nucleus	beta-catenin binding|DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(5)|ovary(3)	8		all_cancers(37;0.0322)	COAD - Colon adenocarcinoma(2;0.24)			CCTCTCTCCGGTATGGGAACG	0.502	GBM(103;1352 1446 1855 4775 8890)		NA											24	97					3.01185e-09	3.94915e-09	0.003954	1	0
SALL1	6299	broad.mit.edu	37	16	51175401	51175401	+	Silent	SNP	C	C	G			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr16:51175401C>G	uc010vgs.1	-	2	763	c.732G>C	c.(730-732)CTG>CTC	p.L244L	SALL1_uc010vgr.1_Silent_p.L147L|SALL1_uc010cbv.2_Intron	NM_002968	NP_002959	Q9NSC2	SALL1_HUMAN	sal-like 1 isoform a	244					adrenal gland development|branching involved in ureteric bud morphogenesis|embryonic digestive tract development|embryonic digit morphogenesis|gonad development|histone deacetylation|inductive cell-cell signaling|mesenchymal to epithelial transition involved in metanephros morphogenesis|negative regulation of transcription from RNA polymerase II promoter|olfactory bulb interneuron differentiation|olfactory bulb mitral cell layer development|olfactory nerve development|outer ear morphogenesis|pituitary gland development|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway|ureteric bud invasion|ventricular septum development	chromocenter|cytoplasm|heterochromatin|nucleus	beta-catenin binding|DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(5)|ovary(3)	8		all_cancers(37;0.0322)	COAD - Colon adenocarcinoma(2;0.24)			CGATCAATTGCAGCTGGTGGA	0.542	GBM(103;1352 1446 1855 4775 8890)		NA											28	71					0	0	0.002836	0	0
CHD9	80205	broad.mit.edu	37	16	53338272	53338272	+	Silent	SNP	T	T	G			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr16:53338272T>G	uc002ehb.2	+	30	6518	c.6354T>G	c.(6352-6354)TCT>TCG	p.S2118S	CHD9_uc002egy.2_Silent_p.S2118S|CHD9_uc002ehc.2_Silent_p.S2118S|CHD9_uc002ehf.2_Silent_p.S1232S|CHD9_uc010cbw.2_Intron|CHD9_uc002ehg.1_Silent_p.S124S	NM_025134	NP_079410	Q3L8U1	CHD9_HUMAN	chromodomain helicase DNA binding protein 9	2118					cellular lipid metabolic process|chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleoplasm	ATP binding|DNA binding|helicase activity|protein binding			lung(2)|central_nervous_system(1)|breast(1)|skin(1)|ovary(1)|kidney(1)	7		all_cancers(37;0.0212)				ACCCAGCTTCTAAGAAACCAA	0.448			NA											5	20					0	0	0.000602	0	0
IRX6	79190	broad.mit.edu	37	16	55360341	55360341	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr16:55360341C>T	uc002ehy.2	+	2	672	c.139C>T	c.(139-141)CTC>TTC	p.L47F	IRX6_uc002ehx.2_Missense_Mutation_p.L47F|IRX6_uc010ccb.1_RNA	NM_024335	NP_077311	P78412	IRX6_HUMAN	iroquois homeobox protein 6	47						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(5)|ovary(1)	6						AGCGCCCGCTCTCTGCTGCGC	0.637			NA											5	25					0	0	0.001168	0	0
CES7	221223	broad.mit.edu	37	16	55883641	55883641	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr16:55883641G>T	uc002eip.2	-	11	1467	c.1318C>A	c.(1318-1320)CAG>AAG	p.Q440K	CES7_uc002eio.2_Intron|CES7_uc002eiq.2_Missense_Mutation_p.Q201K|CES7_uc002eir.2_Missense_Mutation_p.Q334K	NM_001143685	NP_001137157	Q6NT32	EST5A_HUMAN	carboxylesterase 7 isoform 1	440						extracellular region	carboxylesterase activity|methyl indole-3-acetate esterase activity|methyl jasmonate esterase activity|methyl salicylate esterase activity				0				all cancers(182;0.229)|Epithelial(162;0.231)		TCAAAGCACTGAGGCCGGTGC	0.557			NA											10	37					1.52009e-12	2.16373e-12	0.003163	1	0
HPR	3250	broad.mit.edu	37	16	72110394	72110394	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr16:72110394C>A	uc002fby.2	+	5	491	c.461C>A	c.(460-462)GCA>GAA	p.A154E	TXNL4B_uc010cgl.2_Intron	NM_020995	NP_066275	P00739	HPTR_HUMAN	haptoglobin-related protein precursor	154	Peptidase S1.				proteolysis	spherical high-density lipoprotein particle	hemoglobin binding|serine-type endopeptidase activity			central_nervous_system(1)	1		Ovarian(137;0.125)				TCAGAAAATGCAACAGCGAAA	0.463			NA											16	40					6.44725e-10	8.6695e-10	0.002299	1	0
SPATA2L	124044	broad.mit.edu	37	16	89764600	89764600	+	Silent	SNP	C	C	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr16:89764600C>A	uc002foj.2	-	3	482	c.417G>T	c.(415-417)GTG>GTT	p.V139V	SPATA2L_uc002fok.2_Intron	NM_152339	NP_689552	Q8IUW3	SPA2L_HUMAN	spermatogenesis associated 2-like	139											0		Lung NSC(15;0.00043)|all_lung(18;0.000665)|all_hematologic(23;0.0355)		BRCA - Breast invasive adenocarcinoma(80;0.0272)		GCAGGGCGGTCACCATGAGCC	0.657			NA											32	105					2.40579e-17	3.6259e-17	0.00623	1	0
PRPF8	10594	broad.mit.edu	37	17	1557163	1557163	+	Silent	SNP	G	G	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr17:1557163G>A	uc002fte.2	-	38	6249	c.6135C>T	c.(6133-6135)CGC>CGT	p.R2045R		NM_006445	NP_006436	Q6P2Q9	PRP8_HUMAN	U5 snRNP-specific protein	2045						catalytic step 2 spliceosome|nuclear speck|U5 snRNP	protein binding|RNA binding			lung(4)|ovary(2)	6				UCEC - Uterine corpus endometrioid carcinoma (25;0.0855)		TGTTGACAGTGCGAGTCTGTG	0.547			NA											70	197					0	0	0.00361	0	0
SPATA22	84690	broad.mit.edu	37	17	3366057	3366057	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr17:3366057C>A	uc002fvm.2	-	4	414	c.177G>T	c.(175-177)TGG>TGT	p.W59C	SPATA22_uc010vrg.1_Missense_Mutation_p.W43C|SPATA22_uc010vrf.1_Missense_Mutation_p.W59C|SPATA22_uc002fvn.2_Missense_Mutation_p.W59C|SPATA22_uc002fvo.2_Missense_Mutation_p.W59C|SPATA22_uc002fvp.2_Missense_Mutation_p.W59C|SPATA22_uc010ckf.2_Missense_Mutation_p.W16C	NM_032598	NP_115987	Q8NHS9	SPT22_HUMAN	spermatogenesis associated 22	59											0						CTTCCCAGGCCCAATCTCAAA	0.338			NA											62	123					1.17253e-29	1.92311e-29	0.00361	1	0
DLG4	1742	broad.mit.edu	37	17	7097767	7097767	+	Missense_Mutation	SNP	T	T	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr17:7097767T>A	uc002get.3	-	14	2679	c.1478A>T	c.(1477-1479)CAG>CTG	p.Q493L	DLG4_uc010vtm.1_RNA|DLG4_uc010vtn.1_Missense_Mutation_p.Q390L|DLG4_uc010cly.2_Missense_Mutation_p.Q447L|DLG4_uc010vto.1_Missense_Mutation_p.Q490L	NM_001365	NP_001356	P78352	DLG4_HUMAN	post-synaptic density protein 95 isoform 1	450	SH3.				axon guidance|learning|protein complex assembly|protein localization to synapse|signal transduction|synaptic transmission	cell junction|cortical cytoskeleton|endocytic vesicle membrane|neuron spine|postsynaptic density|postsynaptic membrane|synaptosome	protein binding|protein C-terminus binding			ovary(1)|breast(1)	2						GCTCAGGGCCTGGCTCAGGAA	0.597			NA											7	10					0	0	0.006214	0	0
TP53	7157	broad.mit.edu	37	17	7574003	7574003	+	Nonsense_Mutation	SNP	G	G	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr17:7574003G>A	uc002gim.2	-	10	1218	c.1024C>T	c.(1024-1026)CGA>TGA	p.R342*	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Intron|TP53_uc010cne.1_Intron|TP53_uc010cnf.1_3'UTR|TP53_uc010cng.1_3'UTR|TP53_uc002gii.1_Nonsense_Mutation_p.R210*|TP53_uc010cnh.1_3'UTR|TP53_uc010cni.1_3'UTR|TP53_uc002gij.2_Nonsense_Mutation_p.R342*	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	342	Oligomerization.|Interaction with HIPK1 (By similarity).|Interaction with CARM1.|Nuclear export signal.|Interaction with HIPK2.		R -> P (in sporadic cancers; somatic mutation).|R -> Q (in sporadic cancers; somatic mutation).|R -> L (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R342*(49)|p.0?(7)|p.R342fs*3(5)|p.R342P(3)|p.R342Q(2)|p.?(1)|p.R342_N345delRELN(1)|p.I332fs*5(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		TTCAGCTCTCGGAACATCTCG	0.498	Pancreas(47;798 1329 9957 10801)		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumensyndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			7	20					0	0	0.00308	0	0
TP53	7157	broad.mit.edu	37	17	7577095	7577095	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr17:7577095G>T	uc002gim.2	-	8	1037	c.843C>A	c.(841-843)GAC>GAA	p.D281E	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Missense_Mutation_p.D281E|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.D149E|TP53_uc010cng.1_Missense_Mutation_p.D149E|TP53_uc002gii.1_Missense_Mutation_p.D149E|TP53_uc010cnh.1_Missense_Mutation_p.D281E|TP53_uc010cni.1_Missense_Mutation_p.D281E|TP53_uc002gij.2_Missense_Mutation_p.D281E	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	281	|Interaction with E4F1.|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		D -> Y (in sporadic cancers; somatic mutation).|D -> E (in sporadic cancers; somatic mutation).|D -> V (in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation).|DR -> EW (in sporadic cancers; somatic mutation).|D -> R (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|D -> G (in a brain tumor with no family history; germline mutation and in sporadic cancers; somatic mutation).|D -> A (in sporadic cancers; somatic mutation).|D -> N (in LFS; germline mutation and in sporadic cancers; somatic mutation).|D -> H (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.D281E(25)|p.D281H(19)|p.D281N(18)|p.R282W(10)|p.D281G(10)|p.0?(7)|p.D281Y(6)|p.D281D(5)|p.D281V(3)|p.D281fs*63(2)|p.?(2)|p.R280_D281delRD(2)|p.D281A(2)|p.D281_R282>EW(2)|p.A276_R283delACPGRDRR(1)|p.D281fs*24(1)|p.R280fs*62(1)|p.G279fs*59(1)|p.F270_D281del12(1)|p.C275_R283delCACPGRDRR(1)|p.D281_R282insXX(1)|p.L265_K305del41(1)|p.S269fs*21(1)|p.V272_K292del21(1)|p.C275fs*20(1)|p.R282fs*24(1)|p.D281R(1)|p.D281_R282delDR(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CTGTGCGCCGGTCTCTCCCAG	0.557	Pancreas(47;798 1329 9957 10801)		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumensyndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			19	48					1.33834e-09	1.78194e-09	0.007413	1	0
TMEM107	84314	broad.mit.edu	37	17	8079332	8079332	+	Nonsense_Mutation	SNP	G	G	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr17:8079332G>A	uc002gkg.3	-	2	210	c.100C>T	c.(100-102)CAG>TAG	p.Q34*	TMEM107_uc002gkh.3_Nonsense_Mutation_p.Q34*|TMEM107_uc002gki.3_Nonsense_Mutation_p.Q34*|TMEM107_uc002gkj.3_Intron|TMEM107_uc002gkk.2_Nonsense_Mutation_p.Q34*	NM_183065	NP_898888	Q6UX40	TM107_HUMAN	transmembrane protein 107 isoform 2	34						integral to membrane					0						AGGCAGGCCTGTATGTTGCTG	0.607			NA											5	93					0	0	0.000602	0	0
WDR16	146845	broad.mit.edu	37	17	9503448	9503448	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr17:9503448C>G	uc002gly.2	+	6	770	c.701C>G	c.(700-702)CCC>CGC	p.P234R	WDR16_uc002glz.2_Missense_Mutation_p.P166R|WDR16_uc010coc.2_Missense_Mutation_p.P244R	NM_145054	NP_659491	Q8N1V2	WDR16_HUMAN	WD40-repeat protein upregulated in HCC isoform	234						cytoplasm|intracellular membrane-bounded organelle	protein binding			skin(2)|ovary(1)|central_nervous_system(1)	4						AAAATGAACCCCAGGACTAAA	0.428			NA											5	282					0	0	0.001984	0	0
MYH13	8735	broad.mit.edu	37	17	10243518	10243518	+	Missense_Mutation	SNP	T	T	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr17:10243518T>A	uc002gmk.1	-	18	2095	c.2005A>T	c.(2005-2007)ACC>TCC	p.T669S		NM_003802	NP_003793	Q9UKX3	MYH13_HUMAN	myosin, heavy polypeptide 13, skeletal muscle	669	Myosin head-like.|Actin-binding (By similarity).				muscle contraction	muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(4)|skin(2)	6						TGAGGGTGGGTGCTCCTTAAG	0.433			NA											8	29					0	0	0.00308	0	0
MYH2	4620	broad.mit.edu	37	17	10432238	10432238	+	Silent	SNP	C	C	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr17:10432238C>T	uc010coi.2	-	27	3641	c.3513G>A	c.(3511-3513)AAG>AAA	p.K1171K	uc002gml.1_Intron|MYH2_uc002gmp.3_Silent_p.K1171K|MYH2_uc010coj.2_Intron	NM_001100112	NP_001093582	Q9UKX2	MYH2_HUMAN	myosin heavy chain IIa	1171	Potential.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(5)|pancreas(4)|skin(3)|lung(1)|kidney(1)	14						CCTCCCGCTTCTTGTTCATCT	0.597			NA											5	214					0	0	0.001984	0	0
MYH3	4621	broad.mit.edu	37	17	10558331	10558331	+	Silent	SNP	G	G	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr17:10558331G>A	uc002gmq.1	-	2	128	c.51C>T	c.(49-51)CTC>CTT	p.L17L		NM_002470	NP_002461	P11055	MYH3_HUMAN	myosin, heavy chain 3, skeletal muscle,	17	Myosin head-like.				muscle filament sliding|muscle organ development	cytosol|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(4)|central_nervous_system(2)|pancreas(1)	7						CTGACTTCCGGAGGAAAGGAG	0.537			NA											17	193					0	0	0.008871	0	0
MYOCD	93649	broad.mit.edu	37	17	12666523	12666523	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr17:12666523G>T	uc002gnn.2	+	13	2678	c.2379G>T	c.(2377-2379)CAG>CAT	p.Q793H	MYOCD_uc002gno.2_Missense_Mutation_p.Q841H|MYOCD_uc002gnq.2_Missense_Mutation_p.Q517H	NM_153604	NP_705832	Q8IZQ8	MYCD_HUMAN	myocardin isoform 2	793					cardiac muscle cell differentiation|negative regulation of cell proliferation|negative regulation of cyclin-dependent protein kinase activity|positive regulation of smooth muscle cell differentiation|positive regulation of smooth muscle contraction|positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation|regulation of histone acetylation|smooth muscle cell differentiation	nucleus	nucleic acid binding|RNA polymerase II transcription factor binding transcription factor activity|transcription factor binding			central_nervous_system(2)|skin(2)|ovary(1)	5				UCEC - Uterine corpus endometrioid carcinoma (92;0.0969)		CAGGCAGCCAGATCCCCTTTG	0.493			NA											41	110					1.82294e-38	3.02124e-38	0.00361	1	0
FAM18B2	201158	broad.mit.edu	37	17	15406280	15406280	+	Silent	SNP	G	G	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr17:15406280G>A	uc002goq.2	-	6	912	c.729C>T	c.(727-729)CTC>CTT	p.L243L	CDRT4_uc010vvw.1_Intron|FAM18B2_uc010vvx.1_Intron	NM_145301	NP_660344	Q96ET8	F18B2_HUMAN	hypothetical protein LOC201158 isoform 1	243						integral to membrane					0				UCEC - Uterine corpus endometrioid carcinoma (92;0.0872)|BRCA - Breast invasive adenocarcinoma(8;0.0581)|READ - Rectum adenocarcinoma(1115;0.0967)		GCCGCAAGGAGAGAAATAGGC	0.592			NA											3	30					0	0	0.004672	0	0
TRPV2	51393	broad.mit.edu	37	17	16326837	16326837	+	Missense_Mutation	SNP	A	A	G			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr17:16326837A>G	uc002gpy.2	+	5	1047	c.680A>G	c.(679-681)TAC>TGC	p.Y227C	TRPV2_uc002gpz.2_Intron	NM_016113	NP_057197	Q9Y5S1	TRPV2_HUMAN	transient receptor potential cation channel,	227	Cytoplasmic (Potential).|Required for interaction with SLC50A1 (By similarity).|ANK 4.				sensory perception	integral to plasma membrane|melanosome	calcium channel activity			ovary(1)	1				UCEC - Uterine corpus endometrioid carcinoma (92;0.0837)		GTGGTAAGCTACCTCCTGGAG	0.612			NA											3	37					0	0	0.004672	0	0
Unknown	0	broad.mit.edu	37	17	21731297	21731297	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr17:21731297G>A	uc002gyy.3	+	2	724	c.599G>A	c.(598-600)AGC>AAC	p.S200N						SubName: Full=cDNA FLJ51326, highly similar to Homo sapiens ubiquitin B (UBB), mRNA;												NA						TTGCAGGCAAGCAGCTGGAAG	0.527			NA											29	79					0	0	0.009535	0	0
RPL23A	6147	broad.mit.edu	37	17	27050643	27050643	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr17:27050643G>T	uc002hci.2	+	4	465	c.441G>T	c.(439-441)TTG>TTT	p.L147F	RPL23A_uc002hck.1_RNA|SNORD4B_uc002hcn.1_5'Flank	NM_000984	NP_000975	P62750	RL23A_HUMAN	ribosomal protein L23a	147					cell proliferation|endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit|nucleus	nucleotide binding|protein binding|rRNA binding|structural constituent of ribosome			ovary(1)	1	Lung NSC(42;0.00431)					ACGATGCTTTGGATGTTGCCA	0.498			NA											7	284					2.7689e-08	3.53762e-08	0.001984	1	0
AMAC1	146861	broad.mit.edu	37	17	33521019	33521019	+	Missense_Mutation	SNP	C	C	A	rs148354465		TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr17:33521019C>A	uc002hjd.2	-	1	394	c.308G>T	c.(307-309)CGG>CTG	p.R103L		NM_152462	NP_689675	Q8N808	AMAC1_HUMAN	acyl-malonyl condensing enzyme 1	103	DUF6 1.					integral to membrane					0				BRCA - Breast invasive adenocarcinoma(366;0.0917)		GAAGAAGGCCCGGCTTCGGAT	0.592			NA											35	204					1.36615e-20	2.12312e-20	0.002836	1	0
GPR179	440435	broad.mit.edu	37	17	36499029	36499029	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr17:36499029G>T	uc002hpz.2	-	1	665	c.644C>A	c.(643-645)CCG>CAG	p.P215Q		NM_001004334	NP_001004334	Q6PRD1	GP179_HUMAN	GPR158-like 1 precursor	215	Extracellular (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(3)	3	Breast(7;2.97e-12)	Breast(25;0.0101)|Ovarian(249;0.15)				ATCTGCCTGCGGCCACTTGGG	0.627			NA											30	84					9.39024e-22	1.47628e-21	0.009718	1	0
SRCIN1	80725	broad.mit.edu	37	17	36708820	36708820	+	Silent	SNP	C	C	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr17:36708820C>A	uc002hqd.2	-	13	2568	c.2343G>T	c.(2341-2343)CCG>CCT	p.P781P	SRCIN1_uc002hqf.1_Silent_p.P653P|SRCIN1_uc002hqe.2_Silent_p.P635P|SRCIN1_uc002hqg.2_Silent_p.P87P	NM_025248	NP_079524	Q9C0H9	SRCN1_HUMAN	SNAP25-interacting protein	653					exocytosis|negative regulation of protein tyrosine kinase activity|positive regulation of protein tyrosine kinase activity|regulation of cell migration|regulation of dendritic spine morphogenesis|substrate adhesion-dependent cell spreading	actin cytoskeleton|axon|cell junction|cytoplasm|dendrite|postsynaptic density|postsynaptic membrane	protein kinase binding				0						TCTGCAGGCCCGGGAAGTGAG	0.647			NA											3	19					0.004672	0.00496531	0.004672	1	0
ACLY	47	broad.mit.edu	37	17	40063719	40063719	+	Silent	SNP	G	G	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr17:40063719G>A	uc002hyg.2	-	7	886	c.723C>T	c.(721-723)CCC>CCT	p.P241P	ACLY_uc002hyh.2_Silent_p.P241P|ACLY_uc002hyi.2_Silent_p.P295P|ACLY_uc010wfx.1_Silent_p.P295P|ACLY_uc010wfy.1_Intron	NM_001096	NP_001087	P53396	ACLY_HUMAN	ATP citrate lyase isoform 1	241					ATP catabolic process|cellular carbohydrate metabolic process|citrate metabolic process|coenzyme A metabolic process|energy reserve metabolic process|long-chain fatty-acyl-CoA biosynthetic process|positive regulation of cellular metabolic process|triglyceride biosynthetic process	citrate lyase complex|cytosol|nucleus	ATP binding|ATP citrate synthase activity|citrate (pro-3S)-lyase activity|metal ion binding|protein binding|succinate-CoA ligase (ADP-forming) activity			ovary(2)|central_nervous_system(1)	3		Breast(137;0.000143)				CCCGCCCGAAGGGGGGAGGGA	0.577	Colon(64;807 1396 15971 30971)		NA											35	95					0	0	0.004878	0	0
DBF4B	80174	broad.mit.edu	37	17	42828116	42828116	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr17:42828116C>A	uc002ihf.2	+	14	1556	c.1343C>A	c.(1342-1344)CCA>CAA	p.P448Q	DBF4B_uc010wjc.1_Intron	NM_145663	NP_663696	Q8NFT6	DBF4B_HUMAN	DBF4 homolog B isoform 1	448					cell cycle	nucleus	nucleic acid binding|zinc ion binding				0		Prostate(33;0.0322)				TGTCCCTGCCCAGCCTCCTTT	0.622			NA											27	54					1.7881e-09	2.3708e-09	0.008361	1	0
IGF2BP1	10642	broad.mit.edu	37	17	47075138	47075138	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr17:47075138G>A	uc002iom.2	+	1	365	c.31G>A	c.(31-33)GAG>AAG	p.E11K	IGF2BP1_uc010dbj.2_Missense_Mutation_p.E11K	NM_006546	NP_006537	Q9NZI8	IF2B1_HUMAN	insulin-like growth factor 2 mRNA binding	11	RRM 1.				CRD-mediated mRNA stabilization|negative regulation of translation|regulation of mRNA stability involved in response to stress	CRD-mediated mRNA stability complex|cytosol|dendritic spine|lamellipodium|nucleus|plasma membrane|stress granule	mRNA 3'-UTR binding|mRNA 5'-UTR binding|nucleotide binding|protein binding|translation regulator activity			kidney(1)	1						CAACCTCAACGAGAGCGTGAC	0.637	Esophageal Squamous(198;1041 2123 8248 37119 38268)		NA											39	98					0	0	0.00623	0	0
SPAG9	9043	broad.mit.edu	37	17	49072464	49072464	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr17:49072464C>G	uc002itc.2	-	18	2389	c.2180G>C	c.(2179-2181)CGA>CCA	p.R727P	SPAG9_uc002itb.2_Missense_Mutation_p.R713P|SPAG9_uc002itd.2_Missense_Mutation_p.R717P|SPAG9_uc002itf.2_Missense_Mutation_p.R548P|SPAG9_uc002ita.2_Missense_Mutation_p.R570P|SPAG9_uc002ite.2_Missense_Mutation_p.R557P	NM_001130528	NP_001124000	O60271	JIP4_HUMAN	sperm associated antigen 9 isoform 1	727	Potential.				positive regulation of cell migration|positive regulation of muscle cell differentiation|retrograde transport, endosome to Golgi|spermatogenesis	acrosomal vesicle|integral to membrane|perinuclear region of cytoplasm		p.L727L(1)		lung(4)|breast(1)	5			BRCA - Breast invasive adenocarcinoma(22;4.24e-07)			AGAGGCACTTCGCTGTTTACT	0.398			NA											54	120					0	0	0.00361	0	0
C17orf67	339210	broad.mit.edu	37	17	54892331	54892331	+	Splice_Site	SNP	C	C	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr17:54892331C>T	uc010dci.2	-	2	135	c.128_splice	c.e2-1	p.E43_splice	C17orf67_uc002iuq.2_Splice_Site	NM_001085430	NP_001078899	Q0P5P2	CQ067_HUMAN	hypothetical protein LOC339210 precursor							extracellular region					0	Breast(9;2.49e-06)					GGGGAGGTCTCTGGAAAAGTC	0.502			NA											14	506					0	0	0.001855	0	0
MRC2	9902	broad.mit.edu	37	17	60768328	60768328	+	Missense_Mutation	SNP	A	A	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr17:60768328A>T	uc002jad.2	+	28	4433	c.4031A>T	c.(4030-4032)CAG>CTG	p.Q1344L	MRC2_uc002jae.2_Missense_Mutation_p.Q415L|MRC2_uc002jaf.2_Missense_Mutation_p.Q210L	NM_006039	NP_006030	Q9UBG0	MRC2_HUMAN	mannose receptor, C type 2	1344	Extracellular (Potential).|C-type lectin 8.				endocytosis	integral to membrane	receptor activity|sugar binding			ovary(1)|central_nervous_system(1)|skin(1)	3						CTGGTCTGGCAGGACAACACA	0.607			NA											7	18					0	0	0.004482	0	0
ACE	1636	broad.mit.edu	37	17	61566371	61566371	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr17:61566371G>C	uc002jau.1	+	17	2541	c.2519G>C	c.(2518-2520)CGG>CCG	p.R840P	ACE_uc002jav.1_Missense_Mutation_p.R266P|ACE_uc010ddv.1_Missense_Mutation_p.R67P|ACE_uc010wpj.1_Missense_Mutation_p.R266P|ACE_uc002jaw.1_RNA|ACE_uc010wpk.1_Intron	NM_000789	NP_000780	P12821	ACE_HUMAN	angiotensin I converting enzyme 1 isoform 1	840	Extracellular (Potential).|Peptidase M2 2.				arachidonic acid secretion|hormone catabolic process|kidney development|peptide catabolic process|regulation of smooth muscle cell migration	endosome|external side of plasma membrane|extracellular space|integral to membrane|membrane fraction|plasma membrane	actin binding|bradykinin receptor binding|carboxypeptidase activity|chloride ion binding|drug binding|metallopeptidase activity|peptidyl-dipeptidase activity|zinc ion binding			ovary(2)|upper_aerodigestive_tract(1)|pancreas(1)	4					Benazepril(DB00542)|Captopril(DB01197)|Deserpidine(DB01089)|Enalapril(DB00584)|Fosinopril(DB00492)|Lisinopril(DB00722)|Moexipril(DB00691)|Perindopril(DB00790)|Quinapril(DB00881)|Ramipril(DB00178)|Rescinnamine(DB01180)|Spirapril(DB01348)|Trandolapril(DB00519)	GACCTGGAGCGGCTCTTCCAG	0.622			NA											20	46					0	0	0.010504	0	0
LRRC37A3	374819	broad.mit.edu	37	17	62855619	62855619	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr17:62855619C>G	uc002jey.2	-	11	5176	c.4645G>C	c.(4645-4647)GAG>CAG	p.E1549Q	LRRC37A3_uc010wqg.1_Missense_Mutation_p.E667Q|LRRC37A3_uc002jex.1_Missense_Mutation_p.E526Q|LRRC37A3_uc010wqf.1_Missense_Mutation_p.E587Q|LRRC37A3_uc010dek.1_Missense_Mutation_p.E555Q	NM_199340	NP_955372	O60309	L37A3_HUMAN	leucine rich repeat containing 37, member A3	1549	Extracellular (Potential).					integral to membrane					0						ATGTAGTTCTCAGTCTTCCAT	0.488			NA											11	463					0	0	0.00245	0	0
GNA13	10672	broad.mit.edu	37	17	63049634	63049634	+	Nonsense_Mutation	SNP	G	G	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr17:63049634G>A	uc002jfc.2	-	2	705	c.496C>T	c.(496-498)CGA>TGA	p.R166*	GNA13_uc010wqh.1_Nonsense_Mutation_p.R71*	NM_006572	NP_006563	Q14344	GNA13_HUMAN	guanine nucleotide binding protein (G protein),	166					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase D activity|cellular component movement|platelet activation|Rho protein signal transduction	brush border membrane|heterotrimeric G-protein complex|melanosome	D5 dopamine receptor binding|G-protein beta/gamma-subunit complex binding|GTP binding|GTPase activity|signal transducer activity|type 1 angiotensin receptor binding				0						TGAAATTCTCGACGCCGGTCA	0.333			NA											21	95					0	0	0.010504	0	0
AXIN2	8313	broad.mit.edu	37	17	63554271	63554271	+	Nonsense_Mutation	SNP	G	G	T	rs62640025		TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr17:63554271G>T	uc002jfi.2	-	2	757	c.468C>A	c.(466-468)TAC>TAA	p.Y156*	AXIN2_uc010den.1_Nonsense_Mutation_p.Y156*|AXIN2_uc002jfh.2_Nonsense_Mutation_p.Y156*|AXIN2_uc002jfj.1_Nonsense_Mutation_p.Y156*	NM_004655	NP_004646	Q9Y2T1	AXIN2_HUMAN	axin 2	156	RGS.				cellular protein localization|cellular response to organic cyclic compound|dorsal/ventral axis specification|intramembranous ossification|maintenance of DNA repeat elements|mRNA stabilization|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of catenin import into nucleus|negative regulation of cell proliferation|negative regulation of osteoblast differentiation|odontogenesis|positive regulation of cell death|positive regulation of epithelial to mesenchymal transition|positive regulation of protein phosphorylation|regulation of centromeric sister chromatid cohesion|regulation of mismatch repair|Wnt receptor signaling pathway involved in somitogenesis	Axin-APC-beta-catenin-GSK3B complex|cell cortex|centrosome|cytoplasmic membrane-bounded vesicle|cytoplasmic microtubule|nucleus|plasma membrane|postsynaptic density	armadillo repeat domain binding|beta-catenin binding|GTPase activator activity|protein kinase binding|signal transducer activity|ubiquitin protein ligase binding			central_nervous_system(1)|skin(1)	2						CATCTCTTATGTAGGTCTTGG	0.468			NA							Oligodontia_Ectodermal_Dysplasia_and_Colorectal_Polyp_syndrome				77	128					4.78148e-37	7.89695e-37	0.00361	1	0
PRKCA	5578	broad.mit.edu	37	17	64684432	64684432	+	Silent	SNP	T	T	C			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr17:64684432T>C	uc002jfp.1	+	7	743	c.699T>C	c.(697-699)CCT>CCC	p.P233P	PRKCA_uc002jfo.1_Silent_p.P104P	NM_002737	NP_002728	P17252	KPCA_HUMAN	protein kinase C, alpha	233	C2.				activation of phospholipase C activity|energy reserve metabolic process|induction of apoptosis by extracellular signals|intracellular signal transduction|mRNA metabolic process|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of blood vessel endothelial cell migration|regulation of insulin secretion|response to interleukin-1|synaptic transmission	cytosol|endoplasmic reticulum|membrane fraction|nucleoplasm|plasma membrane	ATP binding|enzyme binding|histone kinase activity (H3-T6 specific)|protein kinase C activity|zinc ion binding			central_nervous_system(4)|large_intestine(1)|stomach(1)|lung(1)|breast(1)|ovary(1)	9			BRCA - Breast invasive adenocarcinoma(6;4.68e-09)		Phosphatidylserine(DB00144)|Vitamin E(DB00163)	AATTGAAACCTTCAGACAAAG	0.443			NA											20	137					0	0	0.010504	0	0
ABCA10	10349	broad.mit.edu	37	17	67178860	67178860	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr17:67178860C>A	uc010dfa.1	-	22	3466	c.2587G>T	c.(2587-2589)GAT>TAT	p.D863Y	ABCA10_uc010wqt.1_RNA|ABCA10_uc010dfb.1_Missense_Mutation_p.D464Y	NM_080282	NP_525021	Q8WWZ4	ABCAA_HUMAN	ATP-binding cassette, sub-family A, member 10	863					transport	integral to membrane	ATP binding|ATPase activity			ovary(2)|central_nervous_system(1)|skin(1)	4	Breast(10;6.95e-12)					TAGGAGGGATCATCTGAGCCA	0.353			NA											39	241					5.73237e-09	7.46468e-09	0.00623	1	0
CD300LF	146722	broad.mit.edu	37	17	72700714	72700714	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr17:72700714C>T	uc002jlg.2	-	2	388	c.285G>A	c.(283-285)ATG>ATA	p.M95I	RAB37_uc002jlc.2_Intron|RAB37_uc010dfu.2_Intron|RAB37_uc002jld.2_Intron|CD300LF_uc002jlf.2_Missense_Mutation_p.M98I|CD300LF_uc010dfw.2_RNA|CD300LF_uc002jlh.2_Missense_Mutation_p.M95I|CD300LF_uc002jli.2_Missense_Mutation_p.M98I|CD300LF_uc010wra.1_Missense_Mutation_p.M95I|CD300LF_uc002jlj.1_Missense_Mutation_p.M98I	NM_139018	NP_620587	Q8TDQ1	CLM1_HUMAN	NK inhibitory receptor precursor	95	Ig-like V-type.|Extracellular (Potential).					integral to membrane|plasma membrane	receptor activity			upper_aerodigestive_tract(1)	1						TGAGATCCTCCATGGTCACAG	0.483			NA											57	277					0	0	0.00361	0	0
GRB2	2885	broad.mit.edu	37	17	73317748	73317748	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr17:73317748C>A	uc002jnx.3	-	5	817	c.460G>T	c.(460-462)GTG>TTG	p.V154L	GRB2_uc002jny.3_Missense_Mutation_p.V113L	NM_002086	NP_002077	P62993	GRB2_HUMAN	growth factor receptor-bound protein 2 isoform	154					axon guidance|blood coagulation|cell junction assembly|cell-cell signaling|cellular response to ionizing radiation|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|interspecies interaction between organisms|leukocyte migration|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|positive regulation of reactive oxygen species metabolic process|Ras protein signal transduction|receptor internalization|signal transduction in response to DNA damage|T cell costimulation	cytosol|Golgi apparatus	epidermal growth factor receptor binding|insulin receptor substrate binding|SH3/SH2 adaptor activity			ovary(3)	3	all_cancers(13;5.44e-09)|all_epithelial(9;1.1e-09)|Breast(9;1.85e-09)|all_lung(278;0.222)		all cancers(21;1.09e-07)|Epithelial(20;1.23e-06)|Lung(188;0.185)		Pegademase bovine(DB00061)	ACCTGTGGCACCTGTTCTATG	0.478			NA											13	96					1.3612e-06	1.64594e-06	0.003163	1	0
GALR2	8811	broad.mit.edu	37	17	74071267	74071267	+	Silent	SNP	G	G	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr17:74071267G>T	uc002jqm.1	+	1	384	c.303G>T	c.(301-303)GTG>GTT	p.V101V	SRP68_uc010wsu.1_5'Flank|SRP68_uc002jqk.1_5'Flank|SRP68_uc002jql.1_5'Flank	NM_003857	NP_003848	O43603	GALR2_HUMAN	galanin receptor 2	101	Helical; Name=3; (Potential).				digestion|elevation of cytosolic calcium ion concentration|feeding behavior|learning or memory|muscle contraction	integral to membrane|plasma membrane	galanin receptor activity				0						GCAAGGCGGTGCACTTCCTCA	0.657			NA											37	46					5.43694e-19	8.29986e-19	0.005524	1	0
SEC14L1	6397	broad.mit.edu	37	17	75196633	75196633	+	Missense_Mutation	SNP	A	A	G			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr17:75196633A>G	uc002jto.2	+	9	1154	c.887A>G	c.(886-888)GAG>GGG	p.E296G	SEC14L1_uc010dhc.2_Missense_Mutation_p.E296G|SEC14L1_uc010wth.1_Missense_Mutation_p.E296G|SEC14L1_uc002jtm.2_Missense_Mutation_p.E296G|SEC14L1_uc010wti.1_Missense_Mutation_p.E262G	NM_003003	NP_002994	Q92503	S14L1_HUMAN	SEC14 (S. cerevisiae)-like 1 isoform a	296					transport	Golgi apparatus|integral to membrane	binding			ovary(2)	2						AAAGCCAGAGAGATCATGTGT	0.433			NA											12	292					0	0	0.00245	0	0
P4HB	5034	broad.mit.edu	37	17	79817264	79817264	+	Splice_Site	SNP	C	C	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr17:79817264C>A	uc002kbn.1	-	2	343	c.146_splice	c.e2-1	p.Y49_splice	P4HB_uc002kbm.1_Splice_Site	NM_000918	NP_000909	P07237	PDIA1_HUMAN	prolyl 4-hydroxylase, beta subunit precursor						cell redox homeostasis|glycerol ether metabolic process|lipid metabolic process|lipoprotein metabolic process|peptidyl-proline hydroxylation to 4-hydroxy-L-proline	cell surface|endoplasmic reticulum lumen|ER-Golgi intermediate compartment|extracellular region|melanosome|plasma membrane	electron carrier activity|procollagen-proline 4-dioxygenase activity|protein disulfide isomerase activity|protein disulfide oxidoreductase activity				0	all_neural(118;0.0878)|Ovarian(332;0.12)		BRCA - Breast invasive adenocarcinoma(99;0.013)|OV - Ovarian serous cystadenocarcinoma(97;0.0509)			CAAGGGGCATCTGGAAGCGGA	0.542	Colon(49;444 983 1296 7887 42561)		NA											21	105					1.2644e-06	1.53281e-06	0.010504	1	0
EPB41L3	23136	broad.mit.edu	37	18	5397266	5397266	+	Missense_Mutation	SNP	C	C	A	rs140662824		TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr18:5397266C>A	uc002kmt.1	-	18	2718	c.2632G>T	c.(2632-2634)GGG>TGG	p.G878W	EPB41L3_uc010wzh.1_Missense_Mutation_p.G709W|EPB41L3_uc002kmu.1_Missense_Mutation_p.G656W|EPB41L3_uc010dkq.1_Missense_Mutation_p.G547W|EPB41L3_uc002kms.1_Missense_Mutation_p.G113W|EPB41L3_uc010wze.1_Missense_Mutation_p.G183W|EPB41L3_uc010wzf.1_Missense_Mutation_p.G175W|EPB41L3_uc010wzg.1_Missense_Mutation_p.G150W|EPB41L3_uc010dkr.2_Missense_Mutation_p.G270W	NM_012307	NP_036439	Q9Y2J2	E41L3_HUMAN	erythrocyte membrane protein band 4.1-like 3	878	Carboxyl-terminal (CTD).				cortical actin cytoskeleton organization	cell-cell junction|cytoplasm|cytoskeleton|extrinsic to membrane	actin binding|structural molecule activity			ovary(5)	5						GCAGCATCCCCGCTGTCTCCC	0.617			NA											16	80					1.67942e-08	2.16023e-08	0.006122	1	0
EPB41L3	23136	broad.mit.edu	37	18	5489113	5489113	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr18:5489113C>A	uc002kmt.1	-	2	156	c.70G>T	c.(70-72)GGG>TGG	p.G24W	EPB41L3_uc010wzh.1_Missense_Mutation_p.G24W|EPB41L3_uc002kmu.1_Missense_Mutation_p.G24W|EPB41L3_uc010dkq.1_5'UTR|EPB41L3_uc010dks.1_Missense_Mutation_p.G46W|EPB41L3_uc002kmv.1_5'UTR	NM_012307	NP_036439	Q9Y2J2	E41L3_HUMAN	erythrocyte membrane protein band 4.1-like 3	24					cortical actin cytoskeleton organization	cell-cell junction|cytoplasm|cytoskeleton|extrinsic to membrane	actin binding|structural molecule activity			ovary(5)	5						ccctgcgcccccgccgccTCC	0.522			NA											12	21					9.16793e-09	1.18248e-08	0.00499	1	0
ROCK1	6093	broad.mit.edu	37	18	18586524	18586524	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr18:18586524G>A	uc002kte.2	-	16	2614	c.1673C>T	c.(1672-1674)TCG>TTG	p.S558L		NM_005406	NP_005397	Q13464	ROCK1_HUMAN	Rho-associated, coiled-coil containing protein	558	Interaction with FHOD1.|Potential.				actin cytoskeleton organization|axon guidance|cellular component disassembly involved in apoptosis|cytokinesis|leukocyte tethering or rolling|membrane to membrane docking|Rho protein signal transduction	centriole|cytosol|Golgi membrane	ATP binding|identical protein binding|metal ion binding|protein serine/threonine kinase activity			lung(2)|breast(2)|central_nervous_system(1)	5	Melanoma(1;0.165)					AGCTGTGTCCGATTCTGTCCT	0.358			NA											4	146					0	0	0.009096	0	0
CABLES1	91768	broad.mit.edu	37	18	20716572	20716572	+	Splice_Site	SNP	G	G	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr18:20716572G>T	uc002kuc.2	+	1	845	c.845_splice	c.e1+1	p.R282_splice	CABLES1_uc002kub.2_Intron	NM_001100619	NP_001094089	Q8TDN4	CABL1_HUMAN	Cdk5 and Abl enzyme substrate 1 isoform 2						blood coagulation|cell cycle|cell division|regulation of cell cycle|regulation of cell division	cytosol|nucleus	cyclin-dependent protein kinase regulator activity|protein binding			breast(1)	1	all_cancers(21;0.000102)|all_epithelial(16;2.48e-06)|Lung NSC(20;0.00696)|all_lung(20;0.0197)|Colorectal(14;0.0202)|Ovarian(20;0.127)					AGAGGTCCCGGTGAGTATCCG	0.692			NA											5	16					1.23904e-05	1.44656e-05	0.000602	1	0
CELF4	56853	broad.mit.edu	37	18	34854358	34854359	+	Missense_Mutation	DNP	CC	CC	AA			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr18:34854358_34854359CC>AA	uc002lae.2	-	6	1112_1113	c.716_717GG>TT	c.(715-717)CGG>CTT	p.R239L	CELF4_uc010dnd.1_Missense_Mutation_p.R238L|CELF4_uc002lag.2_Missense_Mutation_p.R229L|CELF4_uc002laf.2_Missense_Mutation_p.R234L|CELF4_uc002lai.2_Missense_Mutation_p.R224L|CELF4_uc002lah.1_5'Flank|CELF4_uc002laj.1_Missense_Mutation_p.A75S	NM_020180	NP_064565	Q9BZC1	CELF4_HUMAN	bruno-like 4, RNA binding protein isoform 1	239	Sufficient for RNA-binding and MSE- dependent splicing activity.|Necessary for TNNT2 exon 5 inclusion.				embryo development|germ cell development|regulation of alternative nuclear mRNA splicing, via spliceosome	cytoplasm|nucleus	BRE binding|nucleotide binding|translation repressor activity, nucleic acid binding			ovary(2)	2						GCTGCATTCGCCGCATCGTGCG	0.673			NA											6	132					0	0	0.004672	0	0
PSTPIP2	9050	broad.mit.edu	37	18	43619913	43619913	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr18:43619913C>A	uc002lbp.3	-	2	230	c.134G>T	c.(133-135)AGG>ATG	p.R45M	PSTPIP2_uc002lbq.3_Missense_Mutation_p.R45M	NM_024430	NP_077748	Q9H939	PPIP2_HUMAN	proline-serine-threonine phosphatase interacting	45	FCH.					membrane				ovary(1)	1						ATCATCGTACCTTTCTTTTAG	0.428			NA											24	171					2.44723e-14	3.56919e-14	0.004656	1	0
DCC	1630	broad.mit.edu	37	18	50705378	50705378	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr18:50705378G>T	uc002lfe.1	+	9	2052	c.1465G>T	c.(1465-1467)GTG>TTG	p.V489L	DCC_uc010xdr.1_Missense_Mutation_p.V337L|DCC_uc010dpf.1_Missense_Mutation_p.V144L	NM_005215	NP_005206	P43146	DCC_HUMAN	netrin receptor DCC precursor	489	Extracellular (Potential).|Fibronectin type-III 1.				apoptosis|induction of apoptosis|negative regulation of collateral sprouting|negative regulation of dendrite development	cytosol|integral to membrane				skin(8)|ovary(6)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	17		all_cancers(7;0.11)|all_epithelial(6;0.00126)		Colorectal(16;0.0251)|COAD - Colon adenocarcinoma(17;0.0942)		TCAGCTCACTGTGGGAAACCT	0.478			NA											14	58					0.00316338	0.00337712	0.003163	1	0
WDR7	23335	broad.mit.edu	37	18	54547264	54547264	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr18:54547264G>C	uc002lgk.1	+	21	3605	c.3394G>C	c.(3394-3396)GTA>CTA	p.V1132L	WDR7_uc010dpk.1_RNA|WDR7_uc002lgl.1_Missense_Mutation_p.V1099L	NM_015285	NP_056100	Q9Y4E6	WDR7_HUMAN	rabconnectin-3 beta isoform 1	1132										ovary(2)|skin(1)	3				Lung(128;0.0238)|Colorectal(16;0.0296)		TTTACTTGGAGTAATAGGAGC	0.423			NA											15	82					0	0	0.004007	0	0
VPS4B	9525	broad.mit.edu	37	18	61077680	61077680	+	Splice_Site	SNP	C	C	G			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr18:61077680C>G	uc002lix.2	-	3	400	c.140_splice	c.e3-1	p.Y47_splice	VPS4B_uc010dpx.2_Splice_Site_p.Y47_splice|VPS4B_uc010dpy.2_Splice_Site|VPS4B_uc010dpz.1_Splice_Site	NM_004869	NP_004860	O75351	VPS4B_HUMAN	vacuolar protein sorting factor 4B						cell cycle|cell division|cellular membrane organization|endosome to lysosome transport via multivesicular body sorting pathway|intracellular cholesterol transport|protein transport|response to lipid	cytosol|early endosome|late endosome membrane|lysosome|nucleus|vacuolar membrane	ATP binding|ATPase activity, coupled|protein C-terminus binding			ovary(1)	1						TGTGCTTCATCTATTAAAGGG	0.318			NA											10	190					0	0	0.000978	0	0
SERPINB10	5273	broad.mit.edu	37	18	61587111	61587111	+	Silent	SNP	C	C	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr18:61587111C>T	uc010xev.1	+	5	552	c.462C>T	c.(460-462)ATC>ATT	p.I154I	SERPINB10_uc010xew.1_Silent_p.I154I	NM_005024	NP_005015	P48595	SPB10_HUMAN	serine (or cysteine) proteinase inhibitor, clade	154						cytoplasm|nucleus	serine-type endopeptidase inhibitor activity			lung(1)|kidney(1)|skin(1)	3		Esophageal squamous(42;0.131)				GAAAGGACATCAACTCTTGGG	0.393			NA											13	95					0	0	0.001368	0	0
STK11	6794	broad.mit.edu	37	19	1219359	1219360	+	Nonsense_Mutation	DNP	GG	GG	TT			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr19:1219359_1219360GG>TT	uc002lrl.1	+	3	1526_1527	c.411_412GG>TT	c.(409-414)CAGGAA>CATTAA	p.137_138QE>H*		NM_000455	NP_000446	Q15831	STK11_HUMAN	serine/threonine protein kinase 11	137_138	Protein kinase.				anoikis|cell cycle arrest|energy reserve metabolic process|insulin receptor signaling pathway|positive regulation of transforming growth factor beta receptor signaling pathway|regulation of fatty acid biosynthetic process|regulation of fatty acid oxidation	cytosol|nucleus	ATP binding|magnesium ion binding|protein serine/threonine kinase activity	p.0?(19)|p.E98_G155del(3)|p.?(2)|p.G52_P179del(1)|p.Q137*(1)		lung(174)|cervix(35)|skin(15)|large_intestine(12)|pancreas(6)|gastrointestinal_tract_(site_indeterminate)(5)|stomach(4)|ovary(4)|breast(2)|upper_aerodigestive_tract(1)|testis(1)|liver(1)|biliary_tract(1)|small_intestine(1)|urinary_tract(1)|oesophagus(1)|prostate(1)|kidney(1)	266		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;7.93e-06)|all_lung(49;1.25e-05)|Breast(49;0.000172)|Renal(1328;0.0183)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|Lung(535;0.00942)|STAD - Stomach adenocarcinoma(1328;0.18)		GTGGCATGCAGGAAATGCTGGA	0.703			14	D|Mis|N|F|S		NSCLC|pancreatic	jejunal harmartoma|ovarian|testicular|pancreatic			Peutz-Jeghers_syndrome	TSP Lung(3;<1E-08)			7	3					0	0	0.004672	0	0
C19orf29	58509	broad.mit.edu	37	19	3624101	3624101	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr19:3624101C>G	uc002lyh.2	-	2	280	c.227G>C	c.(226-228)CGG>CCG	p.R76P	C19orf29_uc002lyi.3_Missense_Mutation_p.R76P|C19orf29_uc010dto.2_RNA	NM_001080543	NP_001074012	Q8WUQ7	CS029_HUMAN	chromosome 19 open reading frame 29	76						catalytic step 2 spliceosome	protein binding				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00253)|STAD - Stomach adenocarcinoma(1328;0.18)		CCACTTGGGCCGCGGGGGGCT	0.677			NA											4	167					0	0	0.001168	0	0
NDUFA11	126328	broad.mit.edu	37	19	5896936	5896936	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr19:5896936C>T	uc002mdq.1	-	2	476	c.170G>A	c.(169-171)GGA>GAA	p.G57E	FUT5_uc010duo.2_5'UTR|NDUFA11_uc002mdp.1_Missense_Mutation_p.G57E|NDUFA11_uc002mdr.1_RNA	NM_175614	NP_783313	Q86Y39	NDUAB_HUMAN	NADH dehydrogenase (ubiquinone) 1 alpha	57					respiratory electron transport chain	integral to membrane|mitochondrial respiratory chain complex I	protein transporter activity			central_nervous_system(1)	1					NADH(DB00157)	CGTGTATTGTCCAACCTTAGC	0.612			NA											7	143					0	0	0.001984	0	0
SH2D3A	10045	broad.mit.edu	37	19	6755233	6755233	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr19:6755233C>T	uc002mft.2	-	5	784	c.590G>A	c.(589-591)AGT>AAT	p.S197N	SH2D3A_uc010xjg.1_Missense_Mutation_p.S75N	NM_005490	NP_005481	Q9BRG2	SH23A_HUMAN	SH2 domain containing 3A	197					JNK cascade|small GTPase mediated signal transduction	intracellular	guanyl-nucleotide exchange factor activity|SH3/SH2 adaptor activity			breast(2)	2						GGCCCTGAGACTGTCGGCAAC	0.637			NA											37	121					0	0	0.005524	0	0
ELAVL1	1994	broad.mit.edu	37	19	8038675	8038675	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr19:8038675C>G	uc002mjb.2	-	4	531	c.364G>C	c.(364-366)GTA>CTA	p.V122L		NM_001419	NP_001410	Q15717	ELAV1_HUMAN	ELAV-like 1	122	RRM 2.				3'-UTR-mediated mRNA stabilization|multicellular organismal development	cytoplasm|nucleoplasm	identical protein binding|mRNA binding|nucleotide binding				0						ATGTCTTCTACGTCCTTCTGG	0.592			NA											15	50					0	0	0.003163	0	0
SMARCA4	6597	broad.mit.edu	37	19	11138617	11138617	+	Missense_Mutation	SNP	A	A	G			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr19:11138617A>G	uc002mqf.3	+	24	3657	c.3373A>G	c.(3373-3375)AGG>GGG	p.R1125G	SMARCA4_uc010dxp.2_Missense_Mutation_p.R1125G|SMARCA4_uc010dxo.2_Missense_Mutation_p.R1125G|SMARCA4_uc002mqg.1_Missense_Mutation_p.R1125G|SMARCA4_uc010dxq.2_Missense_Mutation_p.R1125G|SMARCA4_uc010dxr.2_Missense_Mutation_p.R1125G|SMARCA4_uc002mqj.3_Missense_Mutation_p.R1125G|SMARCA4_uc010dxs.2_Missense_Mutation_p.R1125G|SMARCA4_uc010dxt.1_Missense_Mutation_p.R345G|SMARCA4_uc002mqh.3_Missense_Mutation_p.R248G|SMARCA4_uc002mqi.1_Missense_Mutation_p.R328G	NM_003072	NP_003063	P51532	SMCA4_HUMAN	SWI/SNF-related matrix-associated	1125	Helicase C-terminal.				chromatin remodeling|negative regulation of androgen receptor signaling pathway|negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|negative regulation of transcription from RNA polymerase II promoter|nervous system development|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nBAF complex|npBAF complex|nuclear chromatin|SWI/SNF complex|WINAC complex	androgen receptor binding|ATP binding|DNA binding|DNA-dependent ATPase activity|helicase activity|histone acetyl-lysine binding|identical protein binding|p53 binding|protein N-terminus binding|transcription corepressor activity	p.?(2)		lung(29)|ovary(8)|pancreas(7)|large_intestine(5)|central_nervous_system(5)|skin(3)|prostate(3)|breast(2)|adrenal_gland(1)|stomach(1)|liver(1)|autonomic_ganglia(1)|kidney(1)	67		all_lung(6;0.0512)|Lung NSC(9;0.0568)				TAAATACCTCAGGCTTGATGG	0.507			NA	F|N|Mis		NSCLC				Rhabdoid_Predisposition_syndrome				48	172					0	0	0.00361	0	0
SMARCA4	6597	broad.mit.edu	37	19	11144113	11144113	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr19:11144113G>A	uc002mqf.3	+	26	3978	c.3694G>A	c.(3694-3696)GGC>AGC	p.G1232S	SMARCA4_uc010dxp.2_Missense_Mutation_p.G1232S|SMARCA4_uc010dxo.2_Missense_Mutation_p.G1232S|SMARCA4_uc010dxq.2_Missense_Mutation_p.G1232S|SMARCA4_uc010dxr.2_Missense_Mutation_p.G1232S|SMARCA4_uc002mqj.3_Missense_Mutation_p.G1232S|SMARCA4_uc010dxs.2_Missense_Mutation_p.G1232S|SMARCA4_uc010dxt.1_Missense_Mutation_p.G452S|SMARCA4_uc002mqh.3_Missense_Mutation_p.G355S|SMARCA4_uc002mqi.1_Missense_Mutation_p.G435S	NM_003072	NP_003063	P51532	SMCA4_HUMAN	SWI/SNF-related matrix-associated	1232	Helicase C-terminal.				chromatin remodeling|negative regulation of androgen receptor signaling pathway|negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|negative regulation of transcription from RNA polymerase II promoter|nervous system development|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nBAF complex|npBAF complex|nuclear chromatin|SWI/SNF complex|WINAC complex	androgen receptor binding|ATP binding|DNA binding|DNA-dependent ATPase activity|helicase activity|histone acetyl-lysine binding|identical protein binding|p53 binding|protein N-terminus binding|transcription corepressor activity	p.G1232D(1)		lung(29)|ovary(8)|pancreas(7)|large_intestine(5)|central_nervous_system(5)|skin(3)|prostate(3)|breast(2)|adrenal_gland(1)|stomach(1)|liver(1)|autonomic_ganglia(1)|kidney(1)	67		all_lung(6;0.0512)|Lung NSC(9;0.0568)				GATCCAGGCCGGCATGTTCGA	0.637			NA	F|N|Mis		NSCLC				Rhabdoid_Predisposition_syndrome				16	77					0	0	0.00499	0	0
OR7A10	390892	broad.mit.edu	37	19	14952213	14952213	+	Silent	SNP	T	T	C			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr19:14952213T>C	uc002mzx.1	-	1	477	c.477A>G	c.(475-477)CAA>CAG	p.Q159Q		NM_001005190	NP_001005190	O76100	OR7AA_HUMAN	olfactory receptor, family 7, subfamily A,	159	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	Ovarian(108;0.203)					CCATTAAGCTTTGTAACATGG	0.453			NA											47	67					0	0	0.00361	0	0
EPS15L1	58513	broad.mit.edu	37	19	16503150	16503150	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr19:16503150C>A	uc002ndz.1	-	19	2074	c.2068G>T	c.(2068-2070)GAT>TAT	p.D690Y	EPS15L1_uc002ndx.2_Missense_Mutation_p.D690Y|EPS15L1_uc002ndy.2_RNA|EPS15L1_uc010xpe.1_Missense_Mutation_p.D580Y|EPS15L1_uc010xpf.1_Missense_Mutation_p.D593Y|EPS15L1_uc002nea.1_Missense_Mutation_p.D690Y|EPS15L1_uc010eah.1_Missense_Mutation_p.D692Y	NM_021235	NP_067058	Q9UBC2	EP15R_HUMAN	epidermal growth factor receptor pathway	690	9.|15 X 3 AA repeats of D-P-F.				endocytosis|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway	coated pit|nucleus|plasma membrane	calcium ion binding			ovary(3)|skin(2)	5						GTGAATGGATCCGAGGTAAAT	0.532			NA											18	55					9.16793e-09	1.18248e-08	0.00499	1	0
EPS15L1	58513	broad.mit.edu	37	19	16535930	16535930	+	Silent	SNP	C	C	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr19:16535930C>A	uc002ndz.1	-	9	762	c.756G>T	c.(754-756)GGG>GGT	p.G252G	EPS15L1_uc002ndx.2_Silent_p.G252G|EPS15L1_uc002ndy.2_RNA|EPS15L1_uc010xpe.1_Silent_p.G142G|EPS15L1_uc010xpf.1_Silent_p.G155G|EPS15L1_uc002nea.1_Silent_p.G252G|EPS15L1_uc010eah.1_Silent_p.G252G|EPS15L1_uc002neb.1_Silent_p.G98G|EPS15L1_uc002nec.1_Silent_p.G252G	NM_021235	NP_067058	Q9UBC2	EP15R_HUMAN	epidermal growth factor receptor pathway	252					endocytosis|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway	coated pit|nucleus|plasma membrane	calcium ion binding			ovary(3)|skin(2)	5						GGGACAGGCTCCCTGTGCTGT	0.657			NA											21	32					1.57351e-24	2.52829e-24	0.003755	1	0
SIN3B	23309	broad.mit.edu	37	19	16973310	16973310	+	Silent	SNP	G	G	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr19:16973310G>T	uc002ney.1	+	9	1220	c.1206G>T	c.(1204-1206)CGG>CGT	p.R402R	SIN3B_uc002nex.2_Silent_p.R334R|SIN3B_uc002nez.1_Silent_p.R402R|SIN3B_uc010xpi.1_5'Flank	NM_015260	NP_056075	O75182	SIN3B_HUMAN	SIN3 homolog B, transcription regulator	402	Interaction with SDS3 and HDAC1 (By similarity).|Interaction with NCOR1 (By similarity).				cellular lipid metabolic process|transcription, DNA-dependent	nucleoplasm	protein binding			ovary(2)	2						CCAGCTACCGGGCACTCCCCA	0.582			NA											9	29					0.000442599	0.000491316	0.006214	1	0
MAST3	23031	broad.mit.edu	37	19	18245766	18245766	+	Missense_Mutation	SNP	A	A	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr19:18245766A>T	uc002nhz.3	+	16	1757	c.1757A>T	c.(1756-1758)GAG>GTG	p.E586V		NM_015016	NP_055831	O60307	MAST3_HUMAN	microtubule associated serine/threonine kinase	586	Protein kinase.						ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			large_intestine(2)|ovary(2)|stomach(1)	5						GATACCCCCGAGGAACTCTTC	0.632			NA											8	72					0	0	0.006214	0	0
FKBP8	23770	broad.mit.edu	37	19	18649233	18649233	+	Missense_Mutation	SNP	T	T	C			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr19:18649233T>C	uc002njk.1	-	5	675	c.562A>G	c.(562-564)ATC>GTC	p.I188V	FKBP8_uc002nji.1_Missense_Mutation_p.I26V|FKBP8_uc010xqi.1_Missense_Mutation_p.I217V|FKBP8_uc002njj.1_Missense_Mutation_p.I189V|FKBP8_uc002njl.1_Missense_Mutation_p.I189V|FKBP8_uc002njm.1_Missense_Mutation_p.I188V|FKBP8_uc010ebr.1_Missense_Mutation_p.I27V|FKBP8_uc002njn.2_RNA	NM_012181	NP_036313	Q14318	FKBP8_HUMAN	FK506-binding protein 8	188	PPIase FKBP-type.				apoptosis|interspecies interaction between organisms|intracellular signal transduction|protein folding	integral to endoplasmic reticulum membrane|mitochondrial membrane	FK506 binding|peptidyl-prolyl cis-trans isomerase activity|protein binding			ovary(1)	1						TGCGGGGGGATGTATGGGCTC	0.677			NA											4	24					0	0	0.000602	0	0
SF4	57794	broad.mit.edu	37	19	19389590	19389590	+	Missense_Mutation	SNP	A	A	G			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr19:19389590A>G	uc002nmh.2	-	11	1546	c.1544T>C	c.(1543-1545)CTG>CCG	p.L515P	SF4_uc002nmf.2_Missense_Mutation_p.L65P|SF4_uc002nmg.2_Missense_Mutation_p.L65P|SF4_uc002nmi.2_Missense_Mutation_p.L305P|SF4_uc002nmj.2_Missense_Mutation_p.L305P|SF4_uc002nme.2_Missense_Mutation_p.L65P	NM_172231	NP_757386	Q8IWZ8	SUGP1_HUMAN	splicing factor 4	515					nuclear mRNA splicing, via spliceosome	nucleoplasm|spliceosomal complex	RNA binding				0						CATCTTTGTCAGCTGCTCGGC	0.582			NA											11	15					0	0	0.008291	0	0
ZNF253	56242	broad.mit.edu	37	19	20003499	20003499	+	Silent	SNP	A	A	C			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr19:20003499A>C	uc002noj.2	+	4	1535	c.1443A>C	c.(1441-1443)ATA>ATC	p.I481I	ZNF253_uc002nok.2_Silent_p.I405I|ZNF253_uc002nol.2_RNA	NM_021047	NP_066385	O75346	ZN253_HUMAN	zinc finger protein 253	481					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						AACCCTACATAGTGAAGAATG	0.338			NA											4	78					0	0	0.009096	0	0
ZNF737	100129842	broad.mit.edu	37	19	20736525	20736525	+	Silent	SNP	C	C	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr19:20736525C>A	uc002npa.2	-	2	300	c.120G>T	c.(118-120)CTG>CTT	p.L40L		NM_001159293	NP_001152765	C9JHM3	C9JHM3_HUMAN	zinc finger protein 737	40					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding			ovary(1)	1						CAAGGAAGACCAGGTTTCTGT	0.348			NA											13	74					9.31168e-06	1.09522e-05	0.001855	1	0
ZNF85	7639	broad.mit.edu	37	19	21116875	21116875	+	Nonsense_Mutation	SNP	G	G	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr19:21116875G>T	uc002npg.3	+	2	176	c.49G>T	c.(49-51)GAG>TAG	p.E17*	ZNF85_uc002npf.2_RNA|ZNF85_uc002nph.1_RNA|ZNF85_uc010ecn.2_5'UTR|ZNF85_uc010eco.2_5'Flank|ZNF85_uc002npi.2_5'Flank	NM_003429	NP_003420	Q03923	ZNF85_HUMAN	zinc finger protein 85	17	KRAB.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			central_nervous_system(1)	1						CTCTCTGAAGGAGTGGCAATG	0.333			NA											25	128					1.17739e-12	1.67845e-12	0.005443	1	0
ZNF208	7757	broad.mit.edu	37	19	22155159	22155159	+	Nonsense_Mutation	SNP	C	C	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr19:22155159C>A	uc002nqp.2	-	5	2526	c.2377G>T	c.(2377-2379)GAA>TAA	p.E793*	ZNF208_uc002nqo.1_Intron	NM_007153	NP_009084			zinc finger protein 208											ovary(5)|skin(2)	7		all_lung(12;0.0961)|Lung NSC(12;0.103)				TTGCCACATTCTTCACATTTG	0.383			NA											5	75					2.0095e-06	2.40531e-06	0.001984	1	0
TSHZ3	57616	broad.mit.edu	37	19	31770490	31770490	+	Missense_Mutation	SNP	T	T	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr19:31770490T>A	uc002nsy.3	-	2	274	c.209A>T	c.(208-210)CAT>CTT	p.H70L		NM_020856	NP_065907	Q63HK5	TSH3_HUMAN	zinc finger protein 537	70					negative regulation of transcription, DNA-dependent|regulation of respiratory gaseous exchange by neurological system process	growth cone|nucleus	chromatin binding|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)|skin(2)|pancreas(1)|lung(1)	8	Esophageal squamous(110;0.226)					GTCCATTTCATGGCAGGAAAA	0.592			NA											4	29					0	0	0.001168	0	0
KIAA0355	9710	broad.mit.edu	37	19	34821190	34821190	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr19:34821190C>T	uc002nvd.3	+	7	2060	c.1201C>T	c.(1201-1203)CCT>TCT	p.P401S		NM_014686	NP_055501	O15063	K0355_HUMAN	hypothetical protein LOC9710	401										ovary(1)	1	Esophageal squamous(110;0.162)					CCAGGTTTGCCCTTCCACATG	0.527			NA											4	45					0	0	0.004482	0	0
HAMP	57817	broad.mit.edu	37	19	35775840	35775840	+	Splice_Site	SNP	G	G	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr19:35775840G>T	uc002nyw.2	+	3	222	c.151_splice	c.e3-1	p.P51_splice		NM_021175	NP_066998	P81172	HEPC_HUMAN	hepcidin antimicrobial peptide preproprotein						defense response to bacterium|defense response to fungus|immune response|killing of cells of other organism	extracellular region	hormone activity			central_nervous_system(1)	1	all_lung(56;2.37e-08)|Lung NSC(56;3.66e-08)|Esophageal squamous(110;0.162)		Epithelial(14;7.4e-20)|OV - Ovarian serous cystadenocarcinoma(14;6.47e-19)|all cancers(14;4.17e-17)|LUSC - Lung squamous cell carcinoma(66;0.0417)			CCTTCCCACAGCCCATGTTCC	0.587			NA											20	195					2.4624e-09	3.24216e-09	0.008871	1	0
ZFP14	57677	broad.mit.edu	37	19	36831785	36831785	+	Missense_Mutation	SNP	T	T	C			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr19:36831785T>C	uc002odx.1	-	4	1036	c.943A>G	c.(943-945)AAG>GAG	p.K315E	ZFP14_uc010xtd.1_Missense_Mutation_p.K316E|ZFP14_uc010eex.1_Missense_Mutation_p.K315E	NM_020917	NP_065968	Q9HCL3	ZFP14_HUMAN	zinc finger protein 14-like	315	C2H2-type 6.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1	Esophageal squamous(110;0.162)					CCACATTCCTTACATTCATAG	0.423			NA											10	152					0	0	0.001368	0	0
ZFP82	284406	broad.mit.edu	37	19	36884792	36884792	+	Silent	SNP	A	A	G			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr19:36884792A>G	uc002ody.1	-	5	685	c.450T>C	c.(448-450)TCT>TCC	p.S150S		NM_133466	NP_597723	Q8N141	ZFP82_HUMAN	zinc finger protein 82 homolog	150					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|skin(1)	2						GTTTCTGGTAAGAGGACACCT	0.418			NA											35	114					0	0	0.003755	0	0
ZNF585A	199704	broad.mit.edu	37	19	37643891	37643891	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr19:37643891C>A	uc002ofo.1	-	5	1141	c.910G>T	c.(910-912)GGC>TGC	p.G304C	ZNF585A_uc002ofm.1_Missense_Mutation_p.G249C|ZNF585A_uc002ofn.1_Missense_Mutation_p.G249C	NM_199126	NP_954577	Q6P3V2	Z585A_HUMAN	zinc finger protein 585A	304	C2H2-type 6.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			ovary(1)|central_nervous_system(1)|skin(1)	3			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			AAGGATTTGCCACAGTTACTG	0.428			NA											48	371					2.27781e-18	3.44946e-18	0.00361	1	0
ZNF607	84775	broad.mit.edu	37	19	38190487	38190487	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr19:38190487G>C	uc002ohc.1	-	5	1141	c.545C>G	c.(544-546)CCT>CGT	p.P182R	ZNF607_uc002ohb.1_Missense_Mutation_p.P181R	NM_032689	NP_116078	Q96SK3	ZN607_HUMAN	zinc finger protein 607	182	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0			UCEC - Uterine corpus endometrioid carcinoma (49;0.0775)			AAGGTTTGCAGGATAACTGAA	0.403			NA											13	159					0	0	0.001855	0	0
PLEKHG2	64857	broad.mit.edu	37	19	39914084	39914084	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr19:39914084G>A	uc010xuz.1	+	18	2715	c.2390G>A	c.(2389-2391)GGT>GAT	p.G797D	PLEKHG2_uc010xuy.1_Missense_Mutation_p.G738D|PLEKHG2_uc002olj.2_Intron|PLEKHG2_uc010xva.1_Missense_Mutation_p.G575D	NM_022835	NP_073746	Q9H7P9	PKHG2_HUMAN	common-site lymphoma/leukemia guanine nucleotide	797					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity			skin(2)|pancreas(1)|breast(1)	4	all_cancers(60;3.08e-07)|all_lung(34;2.66e-08)|Lung NSC(34;3e-08)|all_epithelial(25;6.57e-07)|Ovarian(47;0.0569)		Epithelial(26;2.92e-26)|all cancers(26;2.01e-23)|Lung(45;0.000499)|LUSC - Lung squamous cell carcinoma(53;0.000657)			TCGGATCTGGGTGGAGACAGC	0.652			NA											4	22					0	0	0.001168	0	0
TIMM50	92609	broad.mit.edu	37	19	39978750	39978750	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr19:39978750G>T	uc002olu.1	+	9	1188	c.1055G>T	c.(1054-1056)TGC>TTC	p.C352F	TIMM50_uc002olt.1_RNA|TIMM50_uc002olv.1_Missense_Mutation_p.C51F	NM_001001563	NP_001001563	Q3ZCQ8	TIM50_HUMAN	translocase of inner mitochondrial membrane 50	249	Mitochondrial intermembrane (Potential).|FCP1 homology.				mitochondrial membrane organization|protein transport|release of cytochrome c from mitochondria|transmembrane transport	integral to membrane|mitochondrial inner membrane presequence translocase complex|nuclear speck	interleukin-2 receptor binding|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|ribonucleoprotein binding|RNA binding			ovary(1)	1	all_cancers(60;4.04e-06)|all_lung(34;1.77e-07)|Lung NSC(34;2.09e-07)|all_epithelial(25;1.13e-05)|Ovarian(47;0.159)		Epithelial(26;5.89e-26)|all cancers(26;1.96e-23)|LUSC - Lung squamous cell carcinoma(53;0.000657)			GTTGTGGACTGCAAGAAGGAA	0.562			NA											62	328					1.19553e-41	1.98835e-41	0.00361	1	0
FCGBP	8857	broad.mit.edu	37	19	40424077	40424077	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr19:40424077C>T	uc002omp.3	-	4	2134	c.2126G>A	c.(2125-2127)GGG>GAG	p.G709E		NM_003890	NP_003881	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein precursor	709						extracellular region	protein binding			ovary(4)|skin(4)|central_nervous_system(1)	9	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			GAGCCGCTCCCCACCGACCAC	0.632			NA											17	146					0	0	0.010504	0	0
BLVRB	645	broad.mit.edu	37	19	40957343	40957343	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr19:40957343C>T	uc002onw.2	-	4	521	c.391G>A	c.(391-393)GAC>AAC	p.D131N	BLVRB_uc010egw.1_RNA	NM_000713	NP_000704	P30043	BLVRB_HUMAN	biliverdin reductase B (flavin reductase	131					heme catabolic process	cytosol	biliverdin reductase activity|binding|flavin reductase activity				0			Lung(22;6.24e-05)|LUSC - Lung squamous cell carcinoma(20;0.000384)		NADH(DB00157)|Riboflavin(DB00140)	CGGATGTGGTCATCAGTCACA	0.587			NA											4	28					0	0	0.001168	0	0
TGFB1	7040	broad.mit.edu	37	19	41847787	41847787	+	Splice_Site	SNP	C	C	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr19:41847787C>A	uc002oqh.1	-	5	1727	c.860_splice	c.e5+1	p.S287_splice	CYP2F1_uc010xvw.1_Intron	NM_000660	NP_000651	P01137	TGFB1_HUMAN	transforming growth factor, beta 1 precursor						active induction of host immune response by virus|ATP biosynthetic process|cell cycle arrest|cell growth|cell-cell junction organization|chondrocyte differentiation|connective tissue replacement involved in inflammatory response wound healing|epidermal growth factor receptor signaling pathway|evasion of host defenses by virus|hemopoietic progenitor cell differentiation|induction of apoptosis|lymph node development|mitotic cell cycle G1/S transition checkpoint|negative regulation of blood vessel endothelial cell migration|negative regulation of cell growth|negative regulation of cell-cell adhesion|negative regulation of DNA replication|negative regulation of epithelial cell proliferation|negative regulation of fat cell differentiation|negative regulation of macrophage cytokine production|negative regulation of mitotic cell cycle|negative regulation of protein phosphorylation|ossification involved in bone remodeling|pathway-restricted SMAD protein phosphorylation|platelet activation|platelet degranulation|positive regulation of blood vessel endothelial cell migration|positive regulation of bone mineralization|positive regulation of cell division|positive regulation of chemotaxis|positive regulation of collagen biosynthetic process|positive regulation of epithelial to mesenchymal transition|positive regulation of fibroblast migration|positive regulation of interleukin-17 production|positive regulation of isotype switching to IgA isotypes|positive regulation of MAP kinase activity|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of peptidyl-serine phosphorylation|positive regulation of peptidyl-threonine phosphorylation|positive regulation of phosphatidylinositol 3-kinase activity|positive regulation of protein dephosphorylation|positive regulation of protein kinase B signaling cascade|positive regulation of protein secretion|positive regulation of SMAD protein import into nucleus|protein export from nucleus|protein import into nucleus, translocation|receptor catabolic process|regulation of DNA binding|regulation of striated muscle tissue development|regulation of transforming growth factor beta receptor signaling pathway|response to cholesterol|response to estradiol stimulus|response to progesterone stimulus|salivary gland morphogenesis|SMAD protein complex assembly|SMAD protein import into nucleus|transforming growth factor beta receptor signaling pathway|viral infectious cycle	extracellular space|Golgi lumen|nucleus|platelet alpha granule lumen|proteinaceous extracellular matrix	growth factor activity|type II transforming growth factor beta receptor binding				0					Hyaluronidase(DB00070)	ACAAGGCTCACCTGAAGCAAT	0.632			NA											6	54					0.00116845	0.00127467	0.001168	1	0
PSG8	440533	broad.mit.edu	37	19	43258604	43258604	+	Nonsense_Mutation	SNP	G	G	C			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr19:43258604G>C	uc002ouo.2	-	5	1222	c.1124C>G	c.(1123-1125)TCA>TGA	p.S375*	PSG3_uc002ouf.2_Intron|PSG1_uc002oug.1_Intron|PSG8_uc010eim.2_RNA|PSG8_uc002oui.2_Nonsense_Mutation_p.S214*|PSG8_uc002ouh.2_Nonsense_Mutation_p.S375*|PSG8_uc010ein.2_Nonsense_Mutation_p.S253*|PSG8_uc002ouj.3_Nonsense_Mutation_p.S157*|PSG8_uc002ouk.3_Nonsense_Mutation_p.S214*|PSG8_uc002oul.3_Nonsense_Mutation_p.S375*|PSG8_uc002oum.3_Nonsense_Mutation_p.S282*|PSG1_uc002oun.2_Intron|PSG8_uc002oup.3_Nonsense_Mutation_p.S282*	NM_182707	NP_874366	Q9UQ74	PSG8_HUMAN	pregnancy specific beta-1-glycoprotein 8 isoform	375	Ig-like C2-type 3.					extracellular region					0		Prostate(69;0.00899)				CTTTTGTCCTGATAGCTGAAA	0.468			NA											8	464					0	0	0.00308	0	0
PSG9	5678	broad.mit.edu	37	19	43763022	43763022	+	Silent	SNP	G	G	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr19:43763022G>T	uc002owd.3	-	4	1074	c.975C>A	c.(973-975)ATC>ATA	p.I325I	PSG9_uc002owe.3_Intron|PSG9_uc010xwm.1_Silent_p.I232I|PSG9_uc002owf.3_Intron|PSG9_uc002owg.2_Intron|PSG9_uc002owh.2_Intron	NM_002784	NP_002775	Q00887	PSG9_HUMAN	pregnancy specific beta-1-glycoprotein 9	325	Ig-like C2-type 2.				female pregnancy	extracellular region				ovary(1)|skin(1)	2		Prostate(69;0.00682)				GGACATTTAGGATGACTGGGT	0.507			NA											21	125					8.10497e-08	1.01634e-07	0.010504	1	0
KCNN4	3783	broad.mit.edu	37	19	44273613	44273613	+	Silent	SNP	G	G	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr19:44273613G>A	uc002oxl.2	-	6	1426	c.1030C>T	c.(1030-1032)CTG>TTG	p.L344L	KCNN4_uc010eiz.2_Missense_Mutation_p.A236V	NM_002250	NP_002241	O15554	KCNN4_HUMAN	intermediate conductance calcium-activated	344	Calmodulin-binding.				defense response	voltage-gated potassium channel complex	calcium-activated potassium channel activity|calmodulin binding			ovary(2)	2		Prostate(69;0.0352)			Clotrimazole(DB00257)|Halothane(DB01159)|Quinine(DB00468)	GCGGCCAGCAGCTTGCGCTGA	0.577			NA											5	70					0	0	0.001168	0	0
CEACAM20	125931	broad.mit.edu	37	19	45029229	45029229	+	Missense_Mutation	SNP	A	A	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr19:45029229A>T	uc010ejn.1	-	2	117	c.101T>A	c.(100-102)CTC>CAC	p.L34H	CEACAM20_uc010ejo.1_Missense_Mutation_p.L34H|CEACAM20_uc010ejp.1_Missense_Mutation_p.L34H|CEACAM20_uc010ejq.1_Missense_Mutation_p.L34H	NM_001102597	NP_001096067	Q6UY09	CEA20_HUMAN	carcinoembryonic antigen-related cell adhesion	34	Extracellular (Potential).					integral to membrane				large_intestine(2)	2		Prostate(69;0.0352)				GTTGGCATTGAGGGTGAGCTG	0.577			NA											15	135					0	0	0.00245	0	0
MEIS3	56917	broad.mit.edu	37	19	47920559	47920559	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr19:47920559G>T	uc002pgu.2	-	2	508	c.61C>A	c.(61-63)CTG>ATG	p.L21M	MEIS3_uc002pgp.2_5'Flank|MEIS3_uc002pgq.2_Missense_Mutation_p.L102M|MEIS3_uc002pgr.2_Translation_Start_Site|MEIS3_uc002pgt.2_Missense_Mutation_p.L21M|MEIS3_uc002pgv.2_Missense_Mutation_p.L21M|MEIS3_uc002pgs.2_Missense_Mutation_p.L21M|MEIS3_uc010eld.2_Missense_Mutation_p.L21M|MEIS3_uc002pgw.2_Silent_p.P133P	NM_001009813	NP_001009813	Q99687	MEIS3_HUMAN	Meis1, myeloid ecotropic viral integration site	21						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0		all_cancers(25;1.65e-09)|all_epithelial(76;9.95e-08)|all_lung(116;7.27e-07)|Lung NSC(112;1.6e-06)|Ovarian(192;0.0139)|all_neural(266;0.026)|Breast(70;0.0503)		all cancers(93;0.000198)|OV - Ovarian serous cystadenocarcinoma(262;0.000439)|Epithelial(262;0.0113)|GBM - Glioblastoma multiforme(486;0.0223)		AAGCTAGCCAGGGCTGCGGGG	0.687			NA											12	77					6.94344e-10	9.32349e-10	0.006122	1	0
PLA2G4C	8605	broad.mit.edu	37	19	48558262	48558262	+	Silent	SNP	G	G	C			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr19:48558262G>C	uc002phx.2	-	15	1700	c.1302C>G	c.(1300-1302)CCC>CCG	p.P434P	PLA2G4C_uc002phv.2_RNA|PLA2G4C_uc002phw.2_Silent_p.P369P|PLA2G4C_uc010elr.2_Silent_p.P434P|PLA2G4C_uc010xzd.1_Silent_p.P444P	NM_003706	NP_003697	Q9UP65	PA24C_HUMAN	phospholipase A2, group IVC isoform 1 precursor	434	PLA2c.				arachidonic acid metabolic process|glycerophospholipid catabolic process|inflammatory response|intracellular signal transduction|parturition	cytosol|membrane	calcium-independent phospholipase A2 activity|phospholipid binding			ovary(1)|skin(1)	2		all_cancers(25;2.84e-05)|all_lung(116;4.62e-05)|Lung NSC(112;7.61e-05)|all_epithelial(76;0.000192)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;8.09e-05)|all cancers(93;0.000517)|Epithelial(262;0.0135)|GBM - Glioblastoma multiforme(486;0.0717)		CTTGGGGAAAGGGGATCTTGT	0.547			NA											49	63					0	0	0.00361	0	0
CYTH2	9266	broad.mit.edu	37	19	48982391	48982391	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr19:48982391G>T	uc002pjj.3	+	13	1427	c.1127G>T	c.(1126-1128)AGT>ATT	p.S376I	CYTH2_uc002pji.2_RNA	NM_017457	NP_059431	Q99418	CYH2_HUMAN	cytohesin 2 isoform 1	376	PH.				actin cytoskeleton organization|endocytosis|regulation of ARF protein signal transduction|regulation of cell adhesion	cytoplasm|membrane fraction|plasma membrane	ARF guanyl-nucleotide exchange factor activity|protein binding			ovary(1)	1						GCGGCTGTGAGTGTGGACCCC	0.408			NA											6	175					0.00198382	0.00213469	0.001984	1	0
RASIP1	54922	broad.mit.edu	37	19	49224084	49224084	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr19:49224084G>A	uc002pki.2	-	12	3060	c.2863C>T	c.(2863-2865)CAT>TAT	p.H955Y	MAMSTR_uc002pkg.2_5'Flank|RASIP1_uc002pkh.2_Missense_Mutation_p.H216Y	NM_017805	NP_060275	Q5U651	RAIN_HUMAN	Ras-interacting protein 1	955					signal transduction	Golgi stack|perinuclear region of cytoplasm				pancreas(1)	1		all_lung(116;4.89e-06)|all_epithelial(76;7.04e-06)|Lung NSC(112;9.34e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;9.98e-05)|all cancers(93;0.000272)|Epithelial(262;0.0155)|GBM - Glioblastoma multiforme(486;0.0222)		GGAGGCCCATGGCGATAATTG	0.617			NA											29	226					0	0	0.002836	0	0
FGF21	26291	broad.mit.edu	37	19	49260247	49260247	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr19:49260247G>T	uc002pkn.1	+	3	872	c.300G>T	c.(298-300)AGG>AGT	p.R100S	FUT1_uc002pkk.2_5'Flank|FUT1_uc002pkm.1_5'Flank|FGF21_uc002pko.1_Missense_Mutation_p.R100S	NM_019113	NP_061986	Q9NSA1	FGF21_HUMAN	fibroblast growth factor 21 precursor	100					cell-cell signaling|positive regulation of ERK1 and ERK2 cascade|positive regulation of glucose import	extracellular region|soluble fraction	growth factor activity			breast(1)	1		all_lung(116;1.7e-06)|all_epithelial(76;3.52e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.000134)|all cancers(93;0.000348)|Epithelial(262;0.019)|GBM - Glioblastoma multiforme(486;0.022)		AGACATCCAGGTTCCTGTGCC	0.562			NA											7	253					1.12685e-05	1.32046e-05	0.004482	1	0
TRPM4	54795	broad.mit.edu	37	19	49671273	49671273	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr19:49671273G>A	uc002pmw.2	+	4	439	c.367G>A	c.(367-369)GGG>AGG	p.G123R	TRPM4_uc010emu.2_Missense_Mutation_p.G123R|TRPM4_uc010yak.1_Intron|TRPM4_uc002pmx.2_Intron|TRPM4_uc010emv.2_Intron|TRPM4_uc010yal.1_Intron	NM_017636	NP_060106	Q8TD43	TRPM4_HUMAN	transient receptor potential cation channel,	123	Cytoplasmic (Potential).				dendritic cell chemotaxis|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell proliferation|protein sumoylation|regulation of T cell cytokine production	endoplasmic reticulum|Golgi apparatus|integral to membrane|plasma membrane	ATP binding|calcium activated cation channel activity|calmodulin binding			ovary(1)|central_nervous_system(1)	2		all_lung(116;8.54e-05)|Lung NSC(112;0.000139)|all_neural(266;0.0506)|Ovarian(192;0.15)		all cancers(93;2.88e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.000222)|GBM - Glioblastoma multiforme(486;0.00339)|Epithelial(262;0.00751)		GTCAGTGCTGGGGGGATCGGG	0.672			NA											30	200					0	0	0.009535	0	0
CPT1C	126129	broad.mit.edu	37	19	50214055	50214055	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr19:50214055C>T	uc002ppj.2	+	15	2012	c.1807C>T	c.(1807-1809)CGG>TGG	p.R603W	CPT1C_uc002ppl.3_3'UTR|CPT1C_uc002ppi.2_Missense_Mutation_p.R520W|CPT1C_uc002ppk.2_Missense_Mutation_p.R592W|CPT1C_uc010eng.2_Missense_Mutation_p.R603W|CPT1C_uc010enh.2_Missense_Mutation_p.R603W|CPT1C_uc010ybc.1_3'UTR|CPT1C_uc010eni.1_Missense_Mutation_p.R260W	NM_152359	NP_689572	Q8TCG5	CPT1C_HUMAN	carnitine palmitoyltransferase 1C isoform 2	603	Cytoplasmic (Potential).				fatty acid metabolic process	integral to membrane|mitochondrial outer membrane	carnitine O-palmitoyltransferase activity			ovary(1)|central_nervous_system(1)|pancreas(1)	3		all_lung(116;1.05e-05)|Lung NSC(112;3.77e-05)|all_neural(266;0.107)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.0011)|GBM - Glioblastoma multiforme(134;0.00786)		GGAGACGGTGCGGTCTTGCAC	0.577			NA											4	68					0	0	0.009096	0	0
SHANK1	50944	broad.mit.edu	37	19	51217450	51217450	+	Nonsense_Mutation	SNP	G	G	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr19:51217450G>T	uc002psx.1	-	4	648	c.629C>A	c.(628-630)TCG>TAG	p.S210*		NM_016148	NP_057232	Q9Y566	SHAN1_HUMAN	SH3 and multiple ankyrin repeat domains 1	210					cytoskeletal anchoring at plasma membrane	cell junction|cytoplasm|dendrite|membrane fraction|postsynaptic density|postsynaptic membrane	ionotropic glutamate receptor binding			large_intestine(2)	2		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00493)|GBM - Glioblastoma multiforme(134;0.0199)		TCCCGAATCCGAGTCATGGTA	0.602			NA											5	48					3.59834e-05	4.13983e-05	0.001168	1	0
CLEC11A	6320	broad.mit.edu	37	19	51226833	51226833	+	Silent	SNP	C	C	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr19:51226833C>T	uc002psy.2	+	1	229	c.51C>T	c.(49-51)GGC>GGT	p.G17G		NM_002975	NP_002966	Q9Y240	CLC11_HUMAN	stem cell growth factor precursor	17					positive regulation of cell proliferation	cytoplasm|extracellular region	growth factor activity|sugar binding			ovary(1)	1		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00641)|GBM - Glioblastoma multiforme(134;0.028)		AGCTCTTGGGCTTTGGCCATG	0.393			NA											7	93					0	0	0.00308	0	0
CEACAM18	729767	broad.mit.edu	37	19	51983903	51983903	+	Silent	SNP	C	C	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr19:51983903C>A	uc002pwv.1	+	3	552	c.552C>A	c.(550-552)ACC>ACA	p.T184T		NM_001080405	NP_001073874	A8MTB9	CEA18_HUMAN	carcinoembryonic antigen-related cell adhesion	184						integral to membrane				skin(1)	1		all_neural(266;0.0529)		GBM - Glioblastoma multiforme(134;0.00148)|OV - Ovarian serous cystadenocarcinoma(262;0.00979)		GCAATGAGACCCAAAGAGCAA	0.498			NA											22	113					0.000229342	0.000257602	0.001882	1	0
ZNF577	84765	broad.mit.edu	37	19	52376333	52376333	+	Nonsense_Mutation	SNP	C	C	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr19:52376333C>A	uc010yde.1	-	7	1301	c.910G>T	c.(910-912)GGA>TGA	p.G304*	ZNF577_uc010ydd.1_Intron|ZNF577_uc002pxx.3_Nonsense_Mutation_p.G245*|ZNF577_uc002pxv.2_Nonsense_Mutation_p.G297*|ZNF577_uc002pxw.2_Nonsense_Mutation_p.G238*	NM_032679	NP_116068	Q9BSK1	ZN577_HUMAN	zinc finger protein 577 isoform a	304	C2H2-type 6.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		all_neural(266;0.0602)		GBM - Glioblastoma multiforme(134;0.00161)|OV - Ovarian serous cystadenocarcinoma(262;0.019)		AAGGTTCTTCCACAATCACTG	0.438			NA											33	165					1.36161e-19	2.09208e-19	0.004289	1	0
ZNF649	65251	broad.mit.edu	37	19	52394116	52394116	+	Missense_Mutation	SNP	T	T	C			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr19:52394116T>C	uc002pxy.2	-	5	1541	c.1273A>G	c.(1273-1275)ACG>GCG	p.T425A	ZNF577_uc010ydd.1_5'Flank|ZNF577_uc002pxx.3_5'Flank|ZNF577_uc002pxv.2_5'Flank|ZNF577_uc002pxw.2_5'Flank|ZNF577_uc010yde.1_5'Flank|ZNF577_uc010ydf.1_RNA	NM_023074	NP_075562	Q9BS31	ZN649_HUMAN	zinc finger protein 649	425					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|central_nervous_system(1)|skin(1)	3		all_neural(266;0.0602)		GBM - Glioblastoma multiforme(134;0.00152)|OV - Ovarian serous cystadenocarcinoma(262;0.0185)		CTCTCTCCCGTGTGAGTTCTG	0.428			NA											50	309					0	0	0.00361	0	0
ZNF614	80110	broad.mit.edu	37	19	52520455	52520455	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr19:52520455C>A	uc002pyj.2	-	5	798	c.396G>T	c.(394-396)TTG>TTT	p.L132F	ZNF614_uc002pyi.3_Missense_Mutation_p.L132F|ZNF614_uc010epj.2_5'UTR	NM_025040	NP_079316	Q8N883	ZN614_HUMAN	zinc finger protein 614	132					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|upper_aerodigestive_tract(1)|pancreas(1)|skin(1)	5		all_neural(266;0.0505)		GBM - Glioblastoma multiforme(134;0.00513)|OV - Ovarian serous cystadenocarcinoma(262;0.0177)		TTTTTCTGTACAAGTCAAATG	0.338			NA											10	81					0.000442599	0.000491316	0.006214	1	0
ZNF701	55762	broad.mit.edu	37	19	53086276	53086276	+	Nonsense_Mutation	SNP	G	G	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr19:53086276G>T	uc002pzs.1	+	4	1091	c.964G>T	c.(964-966)GGA>TGA	p.G322*	ZNF701_uc010ydn.1_Nonsense_Mutation_p.G388*	NM_018260	NP_060730	Q9NV72	ZN701_HUMAN	zinc finger protein 701	322					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				OV - Ovarian serous cystadenocarcinoma(262;0.0105)|GBM - Glioblastoma multiforme(134;0.0402)		AGTTCATACTGGAGAGAAACC	0.378	NSCLC(89;451 1475 9611 20673 52284)		NA											4	121					0.00909568	0.00959144	0.009096	1	0
ZNF415	55786	broad.mit.edu	37	19	53612346	53612346	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr19:53612346G>T	uc002qax.2	-	7	1445	c.1096C>A	c.(1096-1098)CAT>AAT	p.H366N	ZNF415_uc002qat.2_Missense_Mutation_p.H330N|ZNF415_uc002qaw.2_Missense_Mutation_p.H318N|ZNF415_uc010yds.1_Missense_Mutation_p.H318N|ZNF415_uc010ydt.1_Missense_Mutation_p.H318N|ZNF415_uc002qau.2_Missense_Mutation_p.H305N|ZNF415_uc002qav.2_Missense_Mutation_p.H330N|ZNF415_uc002qba.2_Missense_Mutation_p.H88N|ZNF415_uc002qay.2_Missense_Mutation_p.H305N|ZNF415_uc002qaz.2_Missense_Mutation_p.H366N	NR_028343		Q09FC8	ZN415_HUMAN	RecName: Full=Zinc finger protein 415;	366	C2H2-type 4.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|microtubule cytoskeleton|nucleolus	DNA binding|zinc ion binding			ovary(1)	1				GBM - Glioblastoma multiforme(134;0.0191)		GTTTTCTGATGTAGTGCAAGG	0.418			NA											9	93					0.00448238	0.00477449	0.004482	1	0
VN1R4	317703	broad.mit.edu	37	19	53770147	53770147	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr19:53770147G>T	uc010ydu.1	-	1	772	c.772C>A	c.(772-774)CTT>ATT	p.L258I		NM_173857	NP_776256	Q7Z5H5	VN1R4_HUMAN	vomeronasal 1 receptor 4	258	Extracellular (Potential).				response to pheromone	actin cytoskeleton|cytoplasm|integral to membrane|plasma membrane	pheromone receptor activity			ovary(2)	2				GBM - Glioblastoma multiforme(134;0.00294)		TTATCCAAAAGAGCCATACAA	0.478			NA								HNSCC(26;0.072)			21	48					2.89027e-11	4.01756e-11	0.002299	1	0
CACNG7	59284	broad.mit.edu	37	19	54444824	54444824	+	Silent	SNP	C	C	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr19:54444824C>T	uc002qcr.1	+	4	540	c.525C>T	c.(523-525)TAC>TAT	p.Y175Y	CACNG7_uc010era.1_Silent_p.Y175Y	NM_031896	NP_114102	P62955	CCG7_HUMAN	voltage-dependent calcium channel gamma-7	175					regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(1)	1	all_cancers(19;0.0462)|all_epithelial(19;0.0258)|all_lung(19;0.185)|Ovarian(34;0.19)|Lung NSC(19;0.218)			GBM - Glioblastoma multiforme(134;0.0711)		ATTATCGCTACGGGTGGTCTT	0.537			NA											27	165					0	0	0.00632	0	0
SYT5	6861	broad.mit.edu	37	19	55687098	55687098	+	Missense_Mutation	SNP	A	A	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr19:55687098A>T	uc002qjm.1	-	4	1579	c.519T>A	c.(517-519)TTT>TTA	p.F173L	SYT5_uc002qjp.2_Missense_Mutation_p.F170L|SYT5_uc002qjn.1_Missense_Mutation_p.F173L|SYT5_uc002qjo.1_Missense_Mutation_p.F173L	NM_003180	NP_003171	O00445	SYT5_HUMAN	synaptotagmin V	173	Cytoplasmic (Potential).|C2 1.				energy reserve metabolic process|regulation of insulin secretion|synaptic transmission	cell junction|integral to membrane|recycling endosome membrane|synaptic vesicle membrane	metal ion binding|transporter activity				0			BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0452)		AGGTCTCCCCAAAGTGAGGGT	0.622			NA											15	110					0	0	0.003163	0	0
SYT5	6861	broad.mit.edu	37	19	55689649	55689649	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr19:55689649C>T	uc002qjm.1	-	2	1227	c.167G>A	c.(166-168)CGG>CAG	p.R56Q	SYT5_uc002qjp.2_Intron|SYT5_uc002qjn.1_Missense_Mutation_p.R56Q|SYT5_uc002qjo.1_Missense_Mutation_p.R56Q	NM_003180	NP_003171	O00445	SYT5_HUMAN	synaptotagmin V	56	Cytoplasmic (Potential).				energy reserve metabolic process|regulation of insulin secretion|synaptic transmission	cell junction|integral to membrane|recycling endosome membrane|synaptic vesicle membrane	metal ion binding|transporter activity				0			BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0452)		TGTCCGCCTCCGACAGCTCTT	0.627			NA											11	9					0	0	0.001368	0	0
BRSK1	84446	broad.mit.edu	37	19	55817686	55817686	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr19:55817686G>T	uc002qkg.2	+	17	2234	c.1957G>T	c.(1957-1959)GGC>TGC	p.G653C	BRSK1_uc002qkf.2_Missense_Mutation_p.G669C|BRSK1_uc002qkh.2_Missense_Mutation_p.G348C	NM_032430	NP_115806	Q8TDC3	BRSK1_HUMAN	BR serine/threonine kinase 1	653					establishment of cell polarity|G2/M transition DNA damage checkpoint|neuron differentiation|response to UV	cell junction|cytoplasm|nucleus	magnesium ion binding|protein serine/threonine kinase activity			ovary(2)|stomach(1)|lung(1)|breast(1)|skin(1)	6		Renal(1328;0.245)	BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0474)		GGCCAGTGGCGGCCCCTCCGT	0.652			NA											31	31					1.04594e-18	1.59157e-18	0.00623	1	0
NLRP11	204801	broad.mit.edu	37	19	56303674	56303674	+	Nonsense_Mutation	SNP	C	C	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr19:56303674C>A	uc010ygf.1	-	9	3217	c.2506G>T	c.(2506-2508)GAG>TAG	p.E836*	NLRP11_uc002qlz.2_Nonsense_Mutation_p.E683*|NLRP11_uc002qmb.2_Nonsense_Mutation_p.E737*|NLRP11_uc002qmc.2_RNA|NLRP11_uc010ete.1_RNA	NM_145007	NP_659444	P59045	NAL11_HUMAN	NLR family, pyrin domain containing 11	836							ATP binding			ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	6		Colorectal(82;0.0002)		GBM - Glioblastoma multiforme(193;0.0325)		TACTGAAGCTCCTCTAACTGA	0.483			NA											69	84					8.13855e-26	1.32112e-25	0.00361	1	0
ZNF71	58491	broad.mit.edu	37	19	57132930	57132930	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr19:57132930G>T	uc002qnm.3	+	3	513	c.275G>T	c.(274-276)CGG>CTG	p.R92L		NM_021216	NP_067039	Q9NQZ8	ZNF71_HUMAN	zinc finger protein 71	92						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(1)	1				GBM - Glioblastoma multiforme(193;0.062)|Lung(386;0.0681)|LUSC - Lung squamous cell carcinoma(496;0.18)		GTCCCACCACGGCTGGACGAC	0.587			NA											22	33					9.62636e-23	1.53117e-22	0.002299	1	0
USP29	57663	broad.mit.edu	37	19	57640419	57640419	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr19:57640419C>A	uc002qny.2	+	4	732	c.376C>A	c.(376-378)CTG>ATG	p.L126M		NM_020903	NP_065954	Q9HBJ7	UBP29_HUMAN	ubiquitin specific peptidase 29	126					protein modification process|ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|protein binding|ubiquitin thiolesterase activity			lung(6)|ovary(2)|breast(2)|pancreas(1)	11		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		CAGGAATATGCTGAAGGAAAT	0.348			NA											14	107					2.23348e-06	2.66668e-06	0.004007	1	0
ZNF543	125919	broad.mit.edu	37	19	57839579	57839579	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr19:57839579C>A	uc002qoi.1	+	4	1094	c.749C>A	c.(748-750)ACT>AAT	p.T250N		NM_213598	NP_998763	Q08ER8	ZN543_HUMAN	zinc finger protein 543	250					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)|pancreas(1)	2		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.221)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0257)		ATCATCCACACTGGGGAGAAG	0.502			NA											19	95					3.99206e-14	5.8044e-14	0.007413	1	0
ZNF543	125919	broad.mit.edu	37	19	57839594	57839594	+	Missense_Mutation	SNP	A	A	G			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr19:57839594A>G	uc002qoi.1	+	4	1109	c.764A>G	c.(763-765)TAT>TGT	p.Y255C		NM_213598	NP_998763	Q08ER8	ZN543_HUMAN	zinc finger protein 543	255	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)|pancreas(1)	2		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.221)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0257)		GAGAAGCCCTATAAGTGCATG	0.498			NA											3	101					0	0	0.004672	0	0
ZNF8	7554	broad.mit.edu	37	19	58805952	58805952	+	Missense_Mutation	SNP	A	A	G			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr19:58805952A>G	uc002qry.1	+	4	908	c.778A>G	c.(778-780)ACT>GCT	p.T260A	ZNF8_uc002qrz.2_RNA	NM_021089	NP_066575	P17098	ZNF8_HUMAN	zinc finger protein 8	260	C2H2-type 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		all_cancers(17;6.46e-05)|Lung NSC(17;0.0233)|all_neural(62;0.0381)|all_epithelial(17;0.0427)|all_lung(17;0.057)|Ovarian(87;0.17)|Colorectal(82;0.227)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.00619)		CTACAAATGTACTGACTGTGG	0.483			NA											13	42					0	0	0.00245	0	0
SLC27A5	10998	broad.mit.edu	37	19	59021298	59021298	+	Missense_Mutation	SNP	T	T	C			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr19:59021298T>C	uc002qtc.2	-	3	1083	c.973A>G	c.(973-975)ACA>GCA	p.T325A		NM_012254	NP_036386	Q9Y2P5	S27A5_HUMAN	solute carrier family 27 (fatty acid	325	Cytoplasmic (Probable).				bile acid and bile salt transport|bile acid biosynthetic process|very long-chain fatty acid metabolic process	endoplasmic reticulum membrane|integral to membrane	ATP binding|cholate-CoA ligase activity|long-chain fatty acid-CoA ligase activity				0		all_cancers(17;4.4e-22)|all_epithelial(17;2.15e-16)|Lung NSC(17;1.24e-06)|all_lung(17;5.41e-06)|Colorectal(82;3.46e-05)|Renal(17;0.00179)|all_neural(62;0.00607)|Ovarian(87;0.0443)|Breast(46;0.0928)|Medulloblastoma(540;0.184)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0168)|Lung(386;0.181)		TCATCAGCTGTGGCCCCAGAT	0.567			NA											31	37					0	0	0.002836	0	0
KCNS3	3790	broad.mit.edu	37	2	18112296	18112296	+	Silent	SNP	C	C	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr2:18112296C>T	uc002rcv.2	+	3	472	c.21C>T	c.(19-21)TTC>TTT	p.F7F	KCNS3_uc002rcw.2_Silent_p.F7F	NM_002252	NP_002243	Q9BQ31	KCNS3_HUMAN	potassium voltage-gated channel	7	Cytoplasmic (Potential).				energy reserve metabolic process|regulation of insulin secretion	Golgi apparatus|voltage-gated potassium channel complex	delayed rectifier potassium channel activity|potassium channel regulator activity			ovary(4)	4	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.158)					GTGAGTTTTTCCATCGCCCTG	0.527			NA											33	69					0	0	0.005524	0	0
APOB	338	broad.mit.edu	37	2	21227177	21227177	+	Silent	SNP	G	G	A	rs12713501	byFrequency	TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr2:21227177G>A	uc002red.2	-	28	12179	c.12051C>T	c.(12049-12051)GAC>GAT	p.D4017D		NM_000384	NP_000375	P04114	APOB_HUMAN	apolipoprotein B precursor	4017					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			ovary(11)|skin(9)|central_nervous_system(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	TAGAAAAGTCGTCATCTTCAT	0.512			NA											25	64					0	0	0.007291	0	0
APOB	338	broad.mit.edu	37	2	21233898	21233898	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr2:21233898C>A	uc002red.2	-	26	5970	c.5842G>T	c.(5842-5844)GGC>TGC	p.G1948C		NM_000384	NP_000375	P04114	APOB_HUMAN	apolipoprotein B precursor	1948					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			ovary(11)|skin(9)|central_nervous_system(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	CTTGTGGAGCCTTTGTAATCA	0.483			NA											10	309					2.74318e-10	3.74717e-10	0.006214	1	0
PPM1G	5496	broad.mit.edu	37	2	27608704	27608704	+	Missense_Mutation	SNP	T	T	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr2:27608704T>A	uc002rkl.2	-	5	426	c.319A>T	c.(319-321)ACT>TCT	p.T107S	PPM1G_uc002rkm.2_5'UTR	NM_002707	NP_002698	O15355	PPM1G_HUMAN	protein phosphatase 1G	107					cell cycle arrest|protein dephosphorylation	cytoplasm|nucleus|protein serine/threonine phosphatase complex	metal ion binding|protein serine/threonine phosphatase activity			ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)					ACTTCTTCAGTGGTCAATTTG	0.408			NA											12	69					0	0	0.000978	0	0
ALK	238	broad.mit.edu	37	2	29917880	29917881	+	Splice_Site	DNP	CC	CC	AT			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr2:29917880_29917881CC>AT	uc002rmy.2	-	3	1695	c.788_splice	c.e3-1	p.G263_splice		NM_004304	NP_004295	Q9UM73	ALK_HUMAN	anaplastic lymphoma kinase precursor						protein autophosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity		NPM1/ALK(632)|EML4/ALK(246)|CLTC/ALK(44)|TPM3/ALK(33)|ATIC/ALK(24)|RANBP2/ALK(16)|TPM4/ALK(12)|TFG/ALK(7)|MSN/ALK(6)|CARS/ALK(5)|VCL/ALK(4)|KIF5B/ALK(4)|PPFIBP1/ALK(3)|SEC31A/ALK(3)|SQSTM1/ALK(2)	haematopoietic_and_lymphoid_tissue(726)|lung(262)|autonomic_ganglia(148)|soft_tissue(61)|breast(4)|kidney(4)|large_intestine(3)|skin(3)|ovary(3)|thyroid(2)|central_nervous_system(1)|pancreas(1)	1218	Acute lymphoblastic leukemia(172;0.155)				Adenosine triphosphate(DB00171)	GCACTCCAGACCTGCAATAATA	0.554			NA	T|Mis|A	NPM1|TPM3|TFG|TPM4|ATIC|CLTC|MSN|ALO17|CARS|EML4	ALCL|NSCLC|Neuroblastoma	neuroblastoma			Neuroblastoma_Familial_Clustering_of|Congenital_Central_Hypoventilation_Syndrome				23	84					0	0	0.004672	0	0
SLC8A1	6546	broad.mit.edu	37	2	40657101	40657101	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr2:40657101G>A	uc002rrx.2	-	1	344	c.320C>T	c.(319-321)ACA>ATA	p.T107I	SLC8A1_uc002rry.2_Missense_Mutation_p.T107I|SLC8A1_uc002rrz.2_Missense_Mutation_p.T107I|SLC8A1_uc002rsa.2_Missense_Mutation_p.T107I|SLC8A1_uc002rsd.3_Missense_Mutation_p.T107I|SLC8A1_uc002rsb.1_Missense_Mutation_p.T107I|SLC8A1_uc010fan.1_Missense_Mutation_p.T107I|SLC8A1_uc002rsc.1_Missense_Mutation_p.T107I	NM_021097	NP_066920	P32418	NAC1_HUMAN	solute carrier family 8 (sodium/calcium	107	Cytoplasmic (Potential).				cell communication|muscle contraction|platelet activation	integral to plasma membrane	calcium:sodium antiporter activity|calmodulin binding|heat shock protein binding			ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	4					Alpha-Linolenic Acid(DB00132)|Icosapent(DB00159)	TTCTTGAGATGTGATGACTTC	0.398			NA											31	187					0	0	0.008361	0	0
NRXN1	9378	broad.mit.edu	37	2	50765619	50765619	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr2:50765619C>T	uc010fbq.2	-	10	3512	c.2035G>A	c.(2035-2037)GGC>AGC	p.G679S	NRXN1_uc002rxb.3_Missense_Mutation_p.G311S|NRXN1_uc002rxe.3_Missense_Mutation_p.G639S|NRXN1_uc002rxc.1_RNA	NM_001135659	NP_001129131	P58400	NRX1B_HUMAN	neurexin 1 isoform alpha2 precursor	Error:Variant_position_missing_in_P58400_after_alignment					angiogenesis|neuron cell-cell adhesion|neuronal signal transduction	cell surface|endocytic vesicle|integral to membrane|presynaptic membrane	cell adhesion molecule binding|receptor binding			ovary(2)	2		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.192)	Lung(47;0.0813)|LUSC - Lung squamous cell carcinoma(58;0.116)			CCCACGTAGCCATAGTTGAGC	0.522			NA											51	177					0	0	0.00361	0	0
BCL11A	53335	broad.mit.edu	37	2	60687791	60687791	+	Silent	SNP	C	C	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr2:60687791C>T	uc002sae.1	-	4	2484	c.2256G>A	c.(2254-2256)AAG>AAA	p.K752K	BCL11A_uc002sab.2_Intron|BCL11A_uc002sac.2_Intron|BCL11A_uc010ypi.1_Intron|BCL11A_uc010ypj.1_Silent_p.K718K|BCL11A_uc002sad.1_Silent_p.K600K|BCL11A_uc002saf.1_Silent_p.K718K	NM_022893	NP_075044	Q9H165	BC11A_HUMAN	B-cell CLL/lymphoma 11A isoform 1	752	C2H2-type 4.				negative regulation of axon extension|negative regulation of collateral sprouting|negative regulation of dendrite development|positive regulation of collateral sprouting|positive regulation of neuron projection development|positive regulation of transcription from RNA polymerase II promoter|protein sumoylation|regulation of dendrite development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|cytoplasm|nucleus|nucleus	nucleic acid binding|protein heterodimerization activity|protein homodimerization activity|zinc ion binding			central_nervous_system(6)|breast(3)|ovary(2)|skin(2)	13			LUSC - Lung squamous cell carcinoma(5;9.29e-08)|Lung(5;1.34e-06)|Epithelial(17;0.0562)|all cancers(80;0.199)			TGCTACAGTTCTTGAAGACTT	0.562			NA	T	IGH@	B-CLL								50	96					0	0	0.00361	0	0
OTX1	5013	broad.mit.edu	37	2	63283009	63283009	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr2:63283009G>A	uc002scd.2	+	5	871	c.623G>A	c.(622-624)CGC>CAC	p.R208H	OTX1_uc010ypt.1_Missense_Mutation_p.R142H	NM_014562	NP_055377	P32242	OTX1_HUMAN	orthodenticle homeobox 1	208						nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			pancreas(2)	2	Lung NSC(7;0.121)|all_lung(7;0.211)					TGTATGCAGCGCTCCGTAGCT	0.682			NA											3	7					0	0	0.004672	0	0
DYSF	8291	broad.mit.edu	37	2	71766288	71766288	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr2:71766288G>T	uc002sie.2	+	16	1775	c.1399G>T	c.(1399-1401)GAC>TAC	p.D467Y	DYSF_uc010feg.2_Missense_Mutation_p.D498Y|DYSF_uc010feh.2_Missense_Mutation_p.D467Y|DYSF_uc002sig.3_Missense_Mutation_p.D467Y|DYSF_uc010yqx.1_RNA|DYSF_uc010fee.2_Missense_Mutation_p.D467Y|DYSF_uc010fef.2_Missense_Mutation_p.D498Y|DYSF_uc010fei.2_Missense_Mutation_p.D498Y|DYSF_uc010fek.2_Missense_Mutation_p.D499Y|DYSF_uc010fej.2_Missense_Mutation_p.D468Y|DYSF_uc010fel.2_Missense_Mutation_p.D468Y|DYSF_uc010feo.2_Missense_Mutation_p.D499Y|DYSF_uc010fem.2_Missense_Mutation_p.D468Y|DYSF_uc010fen.2_Missense_Mutation_p.D499Y|DYSF_uc002sif.2_Missense_Mutation_p.D468Y	NM_003494	NP_003485	O75923	DYSF_HUMAN	dysferlin isoform 8	467	Cytoplasmic (Potential).|C2 3.					cytoplasmic vesicle membrane|integral to membrane|sarcolemma	calcium-dependent phospholipid binding			ovary(3)|breast(2)|pancreas(1)|skin(1)	7						TTGCTCTAGGGACCGCCTGAC	0.557			NA											9	91					6.40141e-05	7.33801e-05	0.000978	1	0
SMYD5	10322	broad.mit.edu	37	2	73449044	73449044	+	Nonsense_Mutation	SNP	G	G	T	rs140745382	byFrequency	TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr2:73449044G>T	uc002siw.2	+	6	657	c.628G>T	c.(628-630)GGA>TGA	p.G210*	SMYD5_uc010yre.1_Nonsense_Mutation_p.G94*|SMYD5_uc002six.1_5'Flank	NM_006062	NP_006053	Q6GMV2	SMYD5_HUMAN	SMYD family member 5	210							metal ion binding				0						TAAACTTCTGGGAGACAAATT	0.473			NA											12	108					2.48551e-13	3.59186e-13	0.00499	1	0
NAT8B	51471	broad.mit.edu	37	2	73927988	73927988	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr2:73927988G>T	uc002sjk.1	-	2	480	c.445C>A	c.(445-447)CGT>AGT	p.R149S		NM_016347	NP_057431	Q9UHF3	NAT8B_HUMAN	N-acetyltransferase 8B	149	N-acetyltransferase.				gastrulation with mouth forming second	integral to membrane	N-acetyltransferase activity				0						CCCTGACCACGGTGCTCATTG	0.562			NA											5	79					0.000157383	0.000176986	0.00308	1	0
LRRTM4	80059	broad.mit.edu	37	2	77746271	77746271	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr2:77746271G>T	uc002snr.2	-	3	1139	c.724C>A	c.(724-726)CGC>AGC	p.R242S	LRRTM4_uc002snq.2_Missense_Mutation_p.R242S|LRRTM4_uc002sns.2_Missense_Mutation_p.R242S|LRRTM4_uc002snt.2_Missense_Mutation_p.R243S	NM_001134745	NP_001128217	Q86VH4	LRRT4_HUMAN	leucine rich repeat transmembrane neuronal 4	242	LRR 8.|Extracellular (Potential).					integral to membrane				pancreas(3)|ovary(1)	4				Colorectal(11;0.059)		CTAATGGAGCGAATCCTGTTC	0.448			NA											5	30					1.024e-07	1.27899e-07	0.000602	1	0
REG3G	130120	broad.mit.edu	37	2	79254299	79254299	+	Splice_Site	SNP	T	T	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr2:79254299T>A	uc002snw.2	+	4	418	c.333_splice	c.e4+2	p.Q111_splice	REG3G_uc002snx.2_Splice_Site_p.Q111_splice|REG3G_uc010ffu.2_Intron	NM_198448	NP_940850	Q6UW15	REG3G_HUMAN	regenerating islet-derived 3 gamma precursor						acute-phase response	extracellular region	sugar binding				0						CCCACACAGGTGCGAGTATAT	0.557			NA											10	98					0	0	0.004007	0	0
REG3A	5068	broad.mit.edu	37	2	79384785	79384785	+	Missense_Mutation	SNP	T	T	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr2:79384785T>A	uc002sod.1	-	4	628	c.373A>T	c.(373-375)AGT>TGT	p.S125C	REG3A_uc002soe.1_Missense_Mutation_p.S125C|REG3A_uc002sof.1_Missense_Mutation_p.S125C	NM_138938	NP_620355	Q06141	REG3A_HUMAN	pancreatitis-associated protein precursor	125	C-type lectin.				acute-phase response|cell proliferation|heterophilic cell-cell adhesion|multicellular organismal development	cytoplasm|extracellular space|soluble fraction	sugar binding			skin(1)	1						ATCACATCACTGCTACTCCAC	0.542			NA											7	133					0	0	0.001984	0	0
CTNNA2	1496	broad.mit.edu	37	2	80136743	80136743	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr2:80136743G>C	uc010ysh.1	+	6	881	c.876G>C	c.(874-876)ATG>ATC	p.M292I	CTNNA2_uc010yse.1_Missense_Mutation_p.M292I|CTNNA2_uc010ysf.1_Missense_Mutation_p.M292I|CTNNA2_uc010ysg.1_Missense_Mutation_p.M292I	NM_004389	NP_004380	P26232	CTNA2_HUMAN	catenin, alpha 2 isoform 1	292					axonogenesis|brain morphogenesis|cell-cell adhesion|dendrite morphogenesis|muscle cell differentiation|positive regulation of muscle cell differentiation|prepulse inhibition|radial glia guided migration of Purkinje cell|regulation of synapse structural plasticity	actin cytoskeleton|axon|cytosol	cadherin binding|structural constituent of cytoskeleton			pancreas(4)|lung(3)|breast(1)|skin(1)	9						TGGACCCCATGACGTTCAGCG	0.562			NA											21	167					0	0	0.00632	0	0
ASTL	431705	broad.mit.edu	37	2	96799710	96799710	+	Missense_Mutation	SNP	T	T	C			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr2:96799710T>C	uc010yui.1	-	4	331	c.331A>G	c.(331-333)AAG>GAG	p.K111E		NM_001002036	NP_001002036	Q6HA08	ASTL_HUMAN	astacin-like metalloendopeptidase precursor	111					proteolysis		metalloendopeptidase activity|zinc ion binding				0						TCACCGTACTTGCTGGAGAGC	0.582			NA											21	36					0	0	0.004656	0	0
ITPRIPL1	150771	broad.mit.edu	37	2	96993504	96993504	+	Silent	SNP	C	C	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr2:96993504C>T	uc002svx.2	+	3	1470	c.1135C>T	c.(1135-1137)CTG>TTG	p.L379L	ITPRIPL1_uc010yuk.1_Silent_p.L371L|ITPRIPL1_uc002svy.2_Silent_p.L387L|ITPRIPL1_uc010yul.1_Silent_p.L371L	NM_001008949	NP_001008949	Q6GPH6	IPIL1_HUMAN	inositol 1,4,5-triphosphate receptor interacting	379	Cytoplasmic (Potential).					integral to membrane				central_nervous_system(2)|ovary(1)	3						CTTGGTCTACCTGGTGAGTCA	0.597			NA											14	112					0	0	0.004007	0	0
CNNM4	26504	broad.mit.edu	37	2	97427550	97427550	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr2:97427550G>T	uc002swx.2	+	1	912	c.814G>T	c.(814-816)GTG>TTG	p.V272L		NM_020184	NP_064569	Q6P4Q7	CNNM4_HUMAN	cyclin M4	272	Helical; (Potential).|DUF21.				biomineral tissue development|ion transport|response to stimulus|visual perception	integral to membrane|plasma membrane				breast(2)|ovary(1)	3						CCTCATGGCGGTGGCCTCCTC	0.587			NA											9	124					0.000274275	0.000305179	0.004482	1	0
RGPD3	653489	broad.mit.edu	37	2	107032375	107032375	+	Missense_Mutation	SNP	A	A	C			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr2:107032375A>C	uc010ywi.1	-	21	5052	c.4995T>G	c.(4993-4995)AGT>AGG	p.S1665R		NM_001144013	NP_001137485	A6NKT7	RGPD3_HUMAN	RANBP2-like and GRIP domain containing 3	1665					intracellular transport		binding			ovary(1)	1						AGTGATCTGCACTTTTTGTGG	0.403			NA											33	210					0	0	0.004878	0	0
SEPT10	151011	broad.mit.edu	37	2	110310790	110310790	+	Silent	SNP	T	T	C			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr2:110310790T>C	uc002tew.2	-	9	1414	c.1035A>G	c.(1033-1035)CAA>CAG	p.Q345Q	SEPT10_uc010ywu.1_Silent_p.Q178Q|SEPT10_uc002tex.2_Silent_p.Q322Q|SEPT10_uc002tey.2_Silent_p.Q345Q|SEPT10_uc010ywv.1_Silent_p.Q211Q|SEPT10_uc002tev.1_Silent_p.Q152Q|SEPT10_uc010fjo.2_Intron	NM_144710	NP_653311	Q9P0V9	SEP10_HUMAN	septin 10 isoform 1	345					cell cycle|cell division	septin complex	GTP binding				0						CATAGGTCTCTTGAACACTAA	0.284			NA											23	129					0	0	0.002299	0	0
CKAP2L	150468	broad.mit.edu	37	2	113513676	113513676	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr2:113513676C>A	uc002tie.2	-	4	1351	c.1272G>T	c.(1270-1272)AAG>AAT	p.K424N	CKAP2L_uc002tif.2_Missense_Mutation_p.K13N|CKAP2L_uc010yxp.1_Missense_Mutation_p.K259N|CKAP2L_uc010yxq.1_Missense_Mutation_p.K259N	NM_152515	NP_689728	Q8IYA6	CKP2L_HUMAN	cytoskeleton associated protein 2-like	424						centrosome					0						GGGGAACAGCCTTTTTCAACT	0.408			NA											73	479					3.4887e-51	5.8227e-51	0.00361	1	0
DDX11L2	84771	broad.mit.edu	37	2	114357557	114357557	+	Nonstop_Mutation	SNP	A	A	G	rs115341812	by1000genomes	TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr2:114357557A>G	uc010yxx.1	-	3	709	c.382T>C	c.(382-384)TAG>CAG	p.*128Q						SubName: Full=DEAD/H box polypeptide 11 like 2;												0						GCCTACTTCTAGTGAAACTGG	0.567			NA											4	26					0	0	0.009096	0	0
CNTNAP5	129684	broad.mit.edu	37	2	125175123	125175123	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr2:125175123G>A	uc002tno.2	+	4	849	c.485G>A	c.(484-486)AGT>AAT	p.S162N	CNTNAP5_uc010flu.2_Missense_Mutation_p.S162N	NM_130773	NP_570129	Q8WYK1	CNTP5_HUMAN	contactin associated protein-like 5 precursor	162	F5/8 type C.|Extracellular (Potential).				cell adhesion|signal transduction	integral to membrane	receptor binding			ovary(10)	10				BRCA - Breast invasive adenocarcinoma(221;0.248)		TGGAATCCCAGTGGGAAGATT	0.502			NA											16	26					0	0	0.004007	0	0
CNTNAP5	129684	broad.mit.edu	37	2	125284984	125284984	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr2:125284984C>A	uc002tno.2	+	10	1961	c.1597C>A	c.(1597-1599)CTG>ATG	p.L533M	CNTNAP5_uc010flu.2_Missense_Mutation_p.L534M	NM_130773	NP_570129	Q8WYK1	CNTP5_HUMAN	contactin associated protein-like 5 precursor	533	Laminin G-like 2.|Extracellular (Potential).				cell adhesion|signal transduction	integral to membrane	receptor binding			ovary(10)	10				BRCA - Breast invasive adenocarcinoma(221;0.248)		GCAAGGTTCCCTGGGGAATTT	0.428			NA											41	76					1.62957e-23	2.61393e-23	0.00874	1	0
CCDC74B	91409	broad.mit.edu	37	2	130897872	130897872	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr2:130897872C>T	uc002tqm.1	-	5	818	c.756G>A	c.(754-756)ATG>ATA	p.M252I	CCDC74B_uc010yzw.1_Missense_Mutation_p.M354I|CCDC74B_uc002tqn.1_Missense_Mutation_p.M186I	NM_207310	NP_997193	Q96LY2	CC74B_HUMAN	coiled-coil domain containing 74B	252											0	Colorectal(110;0.1)					CCGCCGCCCCCATCTGCCTGC	0.607			NA											68	123					0	0	0.00361	0	0
LOC401010	401010	broad.mit.edu	37	2	132201617	132201617	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr2:132201617C>T	uc002tst.2	-	1	851	c.385G>A	c.(385-387)GTG>ATG	p.V129M		NR_002826				SubName: Full=cDNA FLJ12694 fis, clone NT2RP1000358, highly similar to Homo sapiens mRNA; cDNA DKFZp564C186 (from clone DKFZp564C186);												0						AAGCAGGGCACTAGCACGCTG	0.592			NA											3	42					0	0	0.004672	0	0
MCM6	4175	broad.mit.edu	37	2	136633884	136633884	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr2:136633884C>T	uc002tuw.2	-	1	128	c.52G>A	c.(52-54)GTC>ATC	p.V18I		NM_005915	NP_005906	Q14566	MCM6_HUMAN	minichromosome maintenance complex component 6	18					cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	MCM complex	ATP binding|identical protein binding				0				BRCA - Breast invasive adenocarcinoma(221;0.166)	Atorvastatin(DB01076)	TCGTCGCGGACCTCCAGGTGC	0.692	Ovarian(196;141 2104 8848 24991 25939)		NA											4	32					0	0	0.000602	0	0
LRP1B	53353	broad.mit.edu	37	2	141528458	141528458	+	Nonsense_Mutation	SNP	G	G	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr2:141528458G>T	uc002tvj.1	-	34	6590	c.5618C>A	c.(5617-5619)TCA>TAA	p.S1873*		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	1873	Extracellular (Potential).|EGF-like 4.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		ACCTTGACATGACATACGGTT	0.373	Colon(99;50 2074 2507 20106)		NA								TSP Lung(27;0.18)			36	95					6.53348e-20	1.00711e-19	0.003755	1	0
ARHGAP15	55843	broad.mit.edu	37	2	143913162	143913162	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr2:143913162C>G	uc002tvm.3	+	2	254	c.103C>G	c.(103-105)CAT>GAT	p.H35D	ARHGAP15_uc010zbl.1_Missense_Mutation_p.H35D	NM_018460	NP_060930	Q53QZ3	RHG15_HUMAN	ARHGAP15	35					regulation of cell shape|small GTPase mediated signal transduction	cytosol|membrane	protein binding|Rac GTPase activator activity			ovary(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(221;0.151)		CAACAGCCACCATGACAGGCT	0.458			NA											10	71					0	0	0.006214	0	0
LYPD6B	130576	broad.mit.edu	37	2	150061878	150061878	+	Silent	SNP	C	C	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr2:150061878C>A	uc002twv.1	+	4	590	c.189C>A	c.(187-189)GCC>GCA	p.A63A	LYPD6B_uc002tww.1_Silent_p.A25A|LYPD6B_uc002twx.1_Silent_p.A25A	NM_177964	NP_808879	Q8NI32	LPD6B_HUMAN	LY6/PLAUR domain containing 6B	39						anchored to membrane|plasma membrane					0						GGGCATTTGCCAAGAACATCA	0.512			NA											123	264					3.97618e-41	6.60144e-41	0.00361	1	0
PLA2R1	22925	broad.mit.edu	37	2	160862202	160862202	+	Nonsense_Mutation	SNP	C	C	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr2:160862202C>A	uc002ube.1	-	11	2002	c.1795G>T	c.(1795-1797)GAG>TAG	p.E599*	PLA2R1_uc010zcp.1_Nonsense_Mutation_p.E599*|PLA2R1_uc002ubf.2_Nonsense_Mutation_p.E599*	NM_007366	NP_031392	Q13018	PLA2R_HUMAN	phospholipase A2 receptor 1 isoform 1 precursor	599	Extracellular (Potential).|C-type lectin 3.				endocytosis	extracellular space|integral to plasma membrane	receptor activity|sugar binding			skin(2)|ovary(1)	3						TGCACCGGCTCGGGTTTCTGC	0.483			NA											20	37					6.70999e-13	9.59437e-13	0.004289	1	0
TBR1	10716	broad.mit.edu	37	2	162274732	162274732	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr2:162274732C>A	uc002ubw.1	+	3	1170	c.868C>A	c.(868-870)CCG>ACG	p.P290T	TBR1_uc010foy.2_Missense_Mutation_p.P3T	NM_006593	NP_006584	Q16650	TBR1_HUMAN	T-box, brain, 1	290	T-box.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|central_nervous_system(1)	2						CTATATGCATCCGGATTCCCC	0.438			NA											17	63					2.94398e-08	3.7512e-08	0.007413	1	0
KCNH7	90134	broad.mit.edu	37	2	163292062	163292062	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr2:163292062G>T	uc002uch.1	-	8	1812	c.1600C>A	c.(1600-1602)CTT>ATT	p.L534I	KCNH7_uc002uci.2_Missense_Mutation_p.L527I	NM_033272	NP_150375	Q9NS40	KCNH7_HUMAN	potassium voltage-gated channel, subfamily H,	534	Helical; Voltage-sensor; Name=Segment S4; (Potential).				regulation of transcription, DNA-dependent	integral to membrane	protein binding|signal transducer activity			ovary(3)|skin(2)	5					Ibutilide(DB00308)	ACGCGCACAAGACGGAGGAGT	0.453	GBM(196;1492 2208 17507 24132 45496)		NA											6	71					0.00116845	0.00127467	0.001168	1	0
KCNH7	90134	broad.mit.edu	37	2	163361078	163361078	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr2:163361078G>C	uc002uch.1	-	6	1215	c.1003C>G	c.(1003-1005)CTC>GTC	p.L335V	KCNH7_uc002uci.2_Missense_Mutation_p.L328V	NM_033272	NP_150375	Q9NS40	KCNH7_HUMAN	potassium voltage-gated channel, subfamily H,	335	Cytoplasmic (Potential).				regulation of transcription, DNA-dependent	integral to membrane	protein binding|signal transducer activity			ovary(3)|skin(2)	5					Ibutilide(DB00308)	TTCAGAGTGAGCTGTGGAATC	0.378	GBM(196;1492 2208 17507 24132 45496)		NA											67	150					0	0	0.00361	0	0
LRP2	4036	broad.mit.edu	37	2	170009461	170009461	+	Silent	SNP	G	G	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr2:170009461G>A	uc002ues.2	-	67	12522	c.12309C>T	c.(12307-12309)TAC>TAT	p.Y4103Y		NM_004525	NP_004516	P98164	LRP2_HUMAN	low density lipoprotein-related protein 2	4103	Extracellular (Potential).				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			ovary(13)|skin(6)|central_nervous_system(4)|large_intestine(3)|kidney(2)|pancreas(1)	29				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	CTCGCACAGTGTAATACACAA	0.478			NA											77	230					0	0	0.00361	0	0
FASTKD1	79675	broad.mit.edu	37	2	170403036	170403036	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr2:170403036C>A	uc002uev.3	-	8	1781	c.1393G>T	c.(1393-1395)GAT>TAT	p.D465Y	FASTKD1_uc002uew.3_RNA|FASTKD1_uc002uex.3_Missense_Mutation_p.D451Y	NM_024622	NP_078898	Q53R41	FAKD1_HUMAN	FAST kinase domains 1	465					apoptosis|cellular respiration	mitochondrion	ATP binding|protein kinase activity			ovary(4)	4						TACATGTGATCATGCTGAATC	0.398			NA											17	118					4.14922e-12	5.85336e-12	0.004007	1	0
PDE11A	50940	broad.mit.edu	37	2	178704991	178704991	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr2:178704991C>T	uc002ulq.2	-	6	1805	c.1487G>A	c.(1486-1488)CGC>CAC	p.R496H	PDE11A_uc002ulp.2_Missense_Mutation_p.R52H|PDE11A_uc002ulr.2_Missense_Mutation_p.R246H|PDE11A_uc002uls.1_Missense_Mutation_p.R138H|PDE11A_uc002ult.1_Missense_Mutation_p.R246H|PDE11A_uc002ulu.1_Missense_Mutation_p.R138H	NM_016953	NP_058649	Q9HCR9	PDE11_HUMAN	phosphodiesterase 11A isoform 4	496	GAF 2.				platelet activation|signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|metal ion binding			ovary(3)|large_intestine(1)	4			OV - Ovarian serous cystadenocarcinoma(117;0.00121)|Epithelial(96;0.00455)|all cancers(119;0.02)			TGCATCAAAGCGCGGATCCTG	0.453			NA							Primary_Pigmented_Nodular_Adrenocortical_Disease_Familial				4	72					0	0	0.000602	0	0
PDE11A	50940	broad.mit.edu	37	2	178936786	178936786	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr2:178936786G>A	uc002ulq.2	-	1	697	c.379C>T	c.(379-381)CGC>TGC	p.R127C	PDE11A_uc002ulr.2_Intron|PDE11A_uc002ult.1_Intron	NM_016953	NP_058649	Q9HCR9	PDE11_HUMAN	phosphodiesterase 11A isoform 4	127					platelet activation|signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|metal ion binding			ovary(3)|large_intestine(1)	4			OV - Ovarian serous cystadenocarcinoma(117;0.00121)|Epithelial(96;0.00455)|all cancers(119;0.02)			GCCTTGGAGCGGGCAAAACTC	0.607			NA							Primary_Pigmented_Nodular_Adrenocortical_Disease_Familial				5	144					0	0	0.001168	0	0
TTN	7273	broad.mit.edu	37	2	179429980	179429980	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr2:179429980G>C	uc010zfg.1	-	275	73399	c.73175C>G	c.(73174-73176)ACA>AGA	p.T24392R	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.T18087R|TTN_uc010zfi.1_Missense_Mutation_p.T18020R|TTN_uc010zfj.1_Missense_Mutation_p.T17895R	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	25319							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTCTGTTGCTGTGCCTGCACT	0.408			NA											34	155					0	0	0.002836	0	0
TTN	7273	broad.mit.edu	37	2	179432976	179432976	+	Silent	SNP	G	G	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr2:179432976G>A	uc010zfg.1	-	275	70403	c.70179C>T	c.(70177-70179)TAC>TAT	p.Y23393Y	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Silent_p.Y17088Y|TTN_uc010zfi.1_Silent_p.Y17021Y|TTN_uc010zfj.1_Silent_p.Y16896Y	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	24320							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTCTAAATTGGTATTCTGTAC	0.403			NA											21	147					0	0	0.002299	0	0
TTN	7273	broad.mit.edu	37	2	179440938	179440938	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr2:179440938C>A	uc010zfg.1	-	275	62441	c.62217G>T	c.(62215-62217)CAG>CAT	p.Q20739H	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.Q14434H|TTN_uc010zfi.1_Missense_Mutation_p.Q14367H|TTN_uc010zfj.1_Missense_Mutation_p.Q14242H|uc002umv.1_5'Flank	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	21666							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTTCTTTAGTCTGAAGATCAG	0.473			NA											11	90					0.00010058	0.000114465	0.001368	1	0
TTN	7273	broad.mit.edu	37	2	179446708	179446708	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr2:179446708C>G	uc010zfg.1	-	264	58908	c.58684G>C	c.(58684-58686)GTT>CTT	p.V19562L	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.V13257L|TTN_uc010zfi.1_Missense_Mutation_p.V13190L|TTN_uc010zfj.1_Missense_Mutation_p.V13065L	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	20489							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ATAGCTGTAACACGGAACTCA	0.443			NA											5	198					0	0	0.000602	0	0
TTN	7273	broad.mit.edu	37	2	179468621	179468621	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr2:179468621C>A	uc010zfg.1	-	231	47313	c.47089G>T	c.(47089-47091)GTT>TTT	p.V15697F	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.V9392F|TTN_uc010zfi.1_Missense_Mutation_p.V9325F|TTN_uc010zfj.1_Missense_Mutation_p.V9200F	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	16624							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCTCCTGCAACCTCTGGATCT	0.408			NA											27	88					9.90768e-06	1.16388e-05	0.004656	1	0
TTN	7273	broad.mit.edu	37	2	179579781	179579781	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr2:179579781C>T	uc010zfg.1	-	87	22624	c.22400G>A	c.(22399-22401)GGG>GAG	p.G7467E	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.G4128E	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	8394							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CTGATATTCCCCAATGTCTGC	0.448			NA											5	294					0	0	0.000602	0	0
TTN	7273	broad.mit.edu	37	2	179584410	179584410	+	Missense_Mutation	SNP	T	T	C			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr2:179584410T>C	uc010zfg.1	-	79	20301	c.20077A>G	c.(20077-20079)ATT>GTT	p.I6693V	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.I3354V	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	7620							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ATGAATGTAATGTGATGTTTG	0.398			NA											20	175					0	0	0.007413	0	0
TTN	7273	broad.mit.edu	37	2	179616645	179616645	+	Silent	SNP	A	A	C			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr2:179616645A>C	uc002unb.2	-	46	10706	c.10482T>G	c.(10480-10482)TCT>TCG	p.S3494S	TTN_uc010zfg.1_Intron|TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Intron	NM_133379	NP_596870	Q8WZ42	TITIN_HUMAN	titin isoform novex-3	3496							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AGGAGCTTGTAGATGATATTC	0.368			NA											15	328					0	0	0.003163	0	0
TTN	7273	broad.mit.edu	37	2	179650683	179650683	+	Silent	SNP	G	G	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr2:179650683G>A	uc010zfg.1	-	14	2486	c.2262C>T	c.(2260-2262)GCC>GCT	p.A754A	TTN_uc010zfh.1_Silent_p.A708A|TTN_uc010zfi.1_Silent_p.A708A|TTN_uc010zfj.1_Silent_p.A708A|TTN_uc002unb.2_Silent_p.A754A|TTN_uc010frg.1_Silent_p.A336A	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	754							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GGGGTTCTGAGGCTGGACGTT	0.488			NA											5	112					0	0	0.001168	0	0
TTN	7273	broad.mit.edu	37	2	179659835	179659835	+	Silent	SNP	G	G	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr2:179659835G>A	uc010zfg.1	-	7	1283	c.1059C>T	c.(1057-1059)TCC>TCT	p.S353S	TTN_uc010zfh.1_Silent_p.S353S|TTN_uc010zfi.1_Silent_p.S353S|TTN_uc010zfj.1_Silent_p.S353S|TTN_uc002unb.2_Silent_p.S353S|TTN_uc010frg.1_Silent_p.S27S	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	353							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CCTCAGATGAGGAGGCCACGT	0.552			NA											11	87					0	0	0.001368	0	0
ITGA4	3676	broad.mit.edu	37	2	182339715	182339715	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr2:182339715G>T	uc002unu.2	+	3	1111	c.348G>T	c.(346-348)AAG>AAT	p.K116N	ITGA4_uc010zfl.1_Missense_Mutation_p.K116N	NM_000885	NP_000876	P13612	ITA4_HUMAN	integrin alpha 4 precursor	116	FG-GAP 2.|Extracellular (Potential).				blood coagulation|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|regulation of immune response	integrin complex	identical protein binding|receptor activity			ovary(3)|lung(1)|central_nervous_system(1)|pancreas(1)	6			OV - Ovarian serous cystadenocarcinoma(117;0.0593)		Natalizumab(DB00108)	CTTGTGGAAAGACTTGTTTGG	0.418			NA											12	43					0.000151284	0.000171758	0.001855	1	0
ITGA4	3676	broad.mit.edu	37	2	182395301	182395301	+	Missense_Mutation	SNP	A	A	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr2:182395301A>T	uc002unu.2	+	24	3352	c.2589A>T	c.(2587-2589)TTA>TTT	p.L863F	ITGA4_uc002unv.2_Missense_Mutation_p.L108F	NM_000885	NP_000876	P13612	ITA4_HUMAN	integrin alpha 4 precursor	863	Extracellular (Potential).				blood coagulation|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|regulation of immune response	integrin complex	identical protein binding|receptor activity			ovary(3)|lung(1)|central_nervous_system(1)|pancreas(1)	6			OV - Ovarian serous cystadenocarcinoma(117;0.0593)		Natalizumab(DB00108)	TGTGTGCATTAGAGCAGCAAA	0.383			NA											5	154					0	0	0.000602	0	0
ZNF804A	91752	broad.mit.edu	37	2	185803479	185803479	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr2:185803479C>A	uc002uph.2	+	4	3950	c.3356C>A	c.(3355-3357)GCA>GAA	p.A1119E		NM_194250	NP_919226	Q7Z570	Z804A_HUMAN	zinc finger protein 804A	1119						intracellular	zinc ion binding			ovary(6)|skin(3)|large_intestine(1)|pancreas(1)	11						gccgcagctgcagGAACCTTT	0.343			NA											29	38					6.32628e-17	9.50446e-17	0.00361	1	0
COL3A1	1281	broad.mit.edu	37	2	189862452	189862452	+	Silent	SNP	A	A	G			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr2:189862452A>G	uc002uqj.1	+	27	2013	c.1896A>G	c.(1894-1896)ACA>ACG	p.T632T		NM_000090	NP_000081	P02461	CO3A1_HUMAN	collagen type III alpha 1 preproprotein	632	Triple-helical region.				axon guidance|cell-matrix adhesion|collagen biosynthetic process|collagen fibril organization|fibril organization|heart development|integrin-mediated signaling pathway|negative regulation of immune response|peptide cross-linking|platelet activation|response to cytokine stimulus|response to radiation|skin development|transforming growth factor beta receptor signaling pathway	collagen type III|extracellular space	extracellular matrix structural constituent|integrin binding|platelet-derived growth factor binding			central_nervous_system(7)|ovary(4)|large_intestine(2)	13			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.141)		Collagenase(DB00048)|Palifermin(DB00039)	AAGGAGACACAGGACCCCCTG	0.373			NA											6	54					0	0	0.001168	0	0
PLCL1	5334	broad.mit.edu	37	2	198949581	198949581	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr2:198949581G>T	uc010fsp.2	+	2	1631	c.1340G>T	c.(1339-1341)AGT>ATT	p.S447I	PLCL1_uc002uuv.3_Missense_Mutation_p.S368I	NM_001114661	NP_001108133	Q15111	PLCL1_HUMAN	RecName: Full=Inactive phospholipase C-like protein 1;          Short=PLC-L1; AltName: Full=Phospholipase C-deleted in lung carcinoma; AltName: Full=Phospholipase C-related but catalytically inactive protein;          Short=PRIP;	447	PI-PLC X-box.				intracellular signal transduction|lipid metabolic process	cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			ovary(1)|skin(1)	2					Quinacrine(DB01103)	CTCGATGTAAGTGATGGTTCA	0.393			NA											4	79					0.00909568	0.00959144	0.009096	1	0
ZDBF2	57683	broad.mit.edu	37	2	207173670	207173670	+	Missense_Mutation	SNP	A	A	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr2:207173670A>T	uc002vbp.2	+	5	4668	c.4418A>T	c.(4417-4419)TAC>TTC	p.Y1473F		NM_020923	NP_065974	Q9HCK1	ZDBF2_HUMAN	zinc finger, DBF-type containing 2	1473							nucleic acid binding|zinc ion binding			ovary(3)	3						CAAGTGTCTTACAAAGAGGCA	0.373			NA											6	52					0	0	0.001984	0	0
CPS1	1373	broad.mit.edu	37	2	211421526	211421526	+	Silent	SNP	G	G	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr2:211421526G>T	uc002vee.3	+	1	201	c.69G>T	c.(67-69)GTG>GTT	p.V23V	CPS1_uc010fur.2_Silent_p.V29V	NM_001875	NP_001866	P31327	CPSM_HUMAN	carbamoyl-phosphate synthetase 1 isoform b	23					carbamoyl phosphate biosynthetic process|citrulline biosynthetic process|glutamine metabolic process|glycogen catabolic process|nitric oxide metabolic process|positive regulation of vasodilation|response to lipopolysaccharide|triglyceride catabolic process|urea cycle	mitochondrial nucleoid	ATP binding|carbamoyl-phosphate synthase (ammonia) activity			ovary(8)|central_nervous_system(3)|breast(1)|skin(1)	13				Epithelial(149;0.00697)|Lung(261;0.0521)|LUSC - Lung squamous cell carcinoma(261;0.0544)|all cancers(144;0.0843)		TTACCAATGTGACTGCACACC	0.373			NA											25	116					3.28513e-13	4.74018e-13	0.003954	1	0
CPS1	1373	broad.mit.edu	37	2	211504752	211504752	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr2:211504752G>A	uc002vee.3	+	24	3060	c.2928G>A	c.(2926-2928)ATG>ATA	p.M976I	CPS1_uc010fur.2_Missense_Mutation_p.M982I|CPS1_uc010fus.2_Missense_Mutation_p.M525I	NM_001875	NP_001866	P31327	CPSM_HUMAN	carbamoyl-phosphate synthetase 1 isoform b	976					carbamoyl phosphate biosynthetic process|citrulline biosynthetic process|glutamine metabolic process|glycogen catabolic process|nitric oxide metabolic process|positive regulation of vasodilation|response to lipopolysaccharide|triglyceride catabolic process|urea cycle	mitochondrial nucleoid	ATP binding|carbamoyl-phosphate synthase (ammonia) activity			ovary(8)|central_nervous_system(3)|breast(1)|skin(1)	13				Epithelial(149;0.00697)|Lung(261;0.0521)|LUSC - Lung squamous cell carcinoma(261;0.0544)|all cancers(144;0.0843)		ACCATGGAATGATGGTGCTAG	0.234			NA											10	101					0	0	0.00245	0	0
ERBB4	2066	broad.mit.edu	37	2	212248650	212248650	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr2:212248650G>A	uc002veg.1	-	28	3715	c.3617C>T	c.(3616-3618)CCA>CTA	p.P1206L	ERBB4_uc002veh.1_Missense_Mutation_p.P1190L|ERBB4_uc010zji.1_Missense_Mutation_p.P1196L|ERBB4_uc010zjj.1_Missense_Mutation_p.P1180L	NM_005235	NP_005226	Q15303	ERBB4_HUMAN	v-erb-a erythroblastic leukemia viral oncogene	1206	Cytoplasmic (Potential).				cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent|transmembrane receptor protein tyrosine kinase signaling pathway	basolateral plasma membrane|cytoplasm|integral to membrane|nucleus	ATP binding|protein binding|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			lung(21)|skin(5)|stomach(2)|breast(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	33		Renal(323;0.06)|Lung NSC(271;0.197)		UCEC - Uterine corpus endometrioid carcinoma (47;0.214)|Epithelial(149;5.86e-06)|all cancers(144;2.95e-05)|Lung(261;0.00244)|LUSC - Lung squamous cell carcinoma(224;0.00266)		GAGGTACAGTGGCTCATTCAC	0.463			NA								TSP Lung(8;0.080)			40	321					0	0	0.007835	0	0
SPAG16	79582	broad.mit.edu	37	2	214794784	214794784	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr2:214794784G>T	uc002veq.2	+	12	1407	c.1315G>T	c.(1315-1317)GTG>TTG	p.V439L	SPAG16_uc010fuz.1_Missense_Mutation_p.V290L|SPAG16_uc002ver.2_Missense_Mutation_p.V385L|SPAG16_uc010zjk.1_Missense_Mutation_p.V345L	NM_024532	NP_078808	Q8N0X2	SPG16_HUMAN	sperm associated antigen 16 isoform 1	439	WD 3.				cilium assembly	cilium axoneme|flagellar axoneme				ovary(1)|skin(1)	2		Renal(323;0.00461)		UCEC - Uterine corpus endometrioid carcinoma (47;0.0525)|Epithelial(149;7.07e-07)|all cancers(144;7.96e-05)|Lung(261;0.00255)|LUSC - Lung squamous cell carcinoma(224;0.00599)		CAGCCGCGCAGTGTGGTCCTG	0.438			NA											18	153					3.73808e-20	5.78092e-20	0.005443	1	0
PRKAG3	53632	broad.mit.edu	37	2	219692035	219692035	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr2:219692035G>A	uc002vjb.1	-	9	956	c.937C>T	c.(937-939)CCG>TCG	p.P313S	PRKAG3_uc010zkn.1_RNA|PRKAG3_uc010fvy.1_Silent_p.T354T	NM_017431	NP_059127	Q9UGI9	AAKG3_HUMAN	AMP-activated protein kinase, non-catalytic	313	CBS 2.				cell cycle arrest|fatty acid biosynthetic process|insulin receptor signaling pathway|intracellular protein kinase cascade|regulation of fatty acid oxidation	cytosol	AMP-activated protein kinase activity|protein kinase binding			ovary(1)|lung(1)	2		Renal(207;0.0474)		Epithelial(149;4.35e-07)|all cancers(144;8.96e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		CCTGACACCGGGTCAAGAACA	0.582			NA											6	54					0	0	0.001984	0	0
ACCN4	55515	broad.mit.edu	37	2	220379622	220379622	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr2:220379622G>T	uc002vma.2	+	1	571	c.557G>T	c.(556-558)GGC>GTC	p.G186V	ACCN4_uc010fwi.1_Missense_Mutation_p.G186V|ACCN4_uc010fwj.1_Missense_Mutation_p.G186V|ACCN4_uc002vly.1_Missense_Mutation_p.G186V|ACCN4_uc002vlz.2_Missense_Mutation_p.G186V|ACCN4_uc002vmb.2_5'Flank	NM_182847	NP_878267	Q96FT7	ACCN4_HUMAN	amiloride-sensitive cation channel 4 isoform 2	186	Cytoplasmic (Potential).					integral to plasma membrane	sodium channel activity|sodium ion transmembrane transporter activity			ovary(2)	2		Renal(207;0.0183)		Epithelial(149;5.47e-10)|all cancers(144;9e-08)|LUSC - Lung squamous cell carcinoma(224;0.00813)|Lung(261;0.0086)|READ - Rectum adenocarcinoma(5;0.156)		CGGGCCTGTGGCCCAGGCCCC	0.716			NA											29	90					7.11191e-15	1.04528e-14	0.002836	1	0
EPHA4	2043	broad.mit.edu	37	2	222291250	222291250	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr2:222291250C>A	uc002vmq.2	-	16	2822	c.2780G>T	c.(2779-2781)CGG>CTG	p.R927L	EPHA4_uc002vmr.2_Missense_Mutation_p.R927L|EPHA4_uc010zlm.1_Missense_Mutation_p.R868L|EPHA4_uc010zln.1_Missense_Mutation_p.R927L	NM_004438	NP_004429	P54764	EPHA4_HUMAN	ephrin receptor EphA4 precursor	927	Cytoplasmic (Potential).|SAM.					integral to plasma membrane	ATP binding|ephrin receptor activity			lung(6)|large_intestine(2)|central_nervous_system(2)|urinary_tract(1)|skin(1)	12		Renal(207;0.0183)		Epithelial(121;5.38e-09)|all cancers(144;2.47e-06)|LUSC - Lung squamous cell carcinoma(224;0.0115)|Lung(261;0.0154)		ATCCTTATACCGGTCCATTTT	0.478			NA											6	75					8.12818e-05	9.27259e-05	0.001984	1	0
SCG2	7857	broad.mit.edu	37	2	224462854	224462854	+	Missense_Mutation	SNP	G	G	A	rs149957287		TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr2:224462854G>A	uc002vnm.2	-	2	1280	c.1147C>T	c.(1147-1149)CGG>TGG	p.R383W		NM_003469	NP_003460	P13521	SCG2_HUMAN	secretogranin II precursor	383					angiogenesis|endothelial cell migration|eosinophil chemotaxis|induction of positive chemotaxis|inflammatory response|MAPKKK cascade|negative regulation of apoptosis|negative regulation of endothelial cell proliferation|positive regulation of endothelial cell proliferation|protein secretion	extracellular space|stored secretory granule	chemoattractant activity|cytokine activity			ovary(1)	1		Renal(207;0.0112)|Lung NSC(271;0.0185)|all_lung(227;0.0271)		Epithelial(121;8.16e-11)|all cancers(144;4.66e-08)|Lung(261;0.00714)|LUSC - Lung squamous cell carcinoma(224;0.008)		TCAAGCTCCCGCTCCGGTTCC	0.483			NA											35	105					0	0	0.005524	0	0
IRS1	3667	broad.mit.edu	37	2	227660130	227660130	+	Missense_Mutation	SNP	T	T	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr2:227660130T>A	uc002voh.3	-	1	3377	c.3325A>T	c.(3325-3327)AGT>TGT	p.S1109C		NM_005544	NP_005535	P35568	IRS1_HUMAN	insulin receptor substrate 1	1109					fibroblast growth factor receptor signaling pathway|glucose homeostasis|insulin receptor signaling pathway|negative regulation of insulin receptor signaling pathway|negative regulation of insulin secretion|nerve growth factor receptor signaling pathway|phosphatidylinositol 3-kinase cascade|phosphatidylinositol-mediated signaling|positive regulation of fatty acid beta-oxidation|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of insulin receptor signaling pathway|positive regulation of phosphatidylinositol 3-kinase activity	caveola|cytosol|insulin receptor complex|microsome|nucleus	insulin receptor binding|insulin-like growth factor receptor binding|phosphatidylinositol 3-kinase binding|protein kinase C binding|SH2 domain binding|transmembrane receptor protein tyrosine kinase adaptor activity			lung(5)|central_nervous_system(4)|ovary(2)|pancreas(1)	12		Renal(207;0.023)|all_lung(227;0.0994)|all_hematologic(139;0.118)|Esophageal squamous(248;0.23)		Epithelial(121;3.03e-11)|all cancers(144;2.42e-08)|Lung(261;0.00712)|LUSC - Lung squamous cell carcinoma(224;0.0137)		CGGGTGGCACTGGGTGTTGAG	0.632			NA											20	85					0	0	0.008871	0	0
COL4A4	1286	broad.mit.edu	37	2	227983373	227983373	+	Silent	SNP	T	T	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr2:227983373T>A	uc010zlt.1	-	7	1131	c.477A>T	c.(475-477)CCA>CCT	p.P159P		NM_000092	NP_000083	P53420	CO4A4_HUMAN	alpha 4 type IV collagen precursor	159	Triple-helical region.				axon guidance|glomerular basement membrane development	basal lamina|collagen type IV	extracellular matrix structural constituent|protein binding			ovary(5)|central_nervous_system(3)|pancreas(1)|breast(1)|skin(1)	11		Renal(207;0.00844)|all_lung(227;0.0187)|Lung NSC(271;0.0879)|all_hematologic(139;0.21)|Esophageal squamous(248;0.242)		Epithelial(121;6.7e-11)|all cancers(144;5.39e-08)|Lung(261;0.0132)|LUSC - Lung squamous cell carcinoma(224;0.0181)		GGGGGCCTCCTGGGCCAAGAG	0.398			NA											8	136					0	0	0.00308	0	0
COL4A3	1285	broad.mit.edu	37	2	228157957	228157957	+	Missense_Mutation	SNP	A	A	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr2:228157957A>T	uc002vom.1	+	38	3423	c.3261A>T	c.(3259-3261)CAA>CAT	p.Q1087H	COL4A3_uc002von.1_Missense_Mutation_p.Q1087H|COL4A3_uc002voo.1_Missense_Mutation_p.Q1087H|COL4A3_uc002vop.1_Missense_Mutation_p.Q1087H|uc002voq.1_Intron|uc002vor.1_Intron	NM_000091	NP_000082	Q01955	CO4A3_HUMAN	alpha 3 type IV collagen isoform 1 precursor	1087	Triple-helical region.				activation of caspase activity|axon guidance|blood circulation|cell adhesion|cell proliferation|cell surface receptor linked signaling pathway|glomerular basement membrane development|induction of apoptosis|negative regulation of angiogenesis|negative regulation of cell proliferation|sensory perception of sound	collagen type IV	extracellular matrix structural constituent|integrin binding|metalloendopeptidase inhibitor activity			skin(2)|ovary(1)	3		all_lung(227;0.00101)|Lung NSC(271;0.00278)|Renal(207;0.0112)|Ovarian(221;0.0129)|all_hematologic(139;0.211)|Esophageal squamous(248;0.247)		Epithelial(121;1.17e-46)|all cancers(144;6.87e-42)|Lung(261;0.0137)|LUSC - Lung squamous cell carcinoma(224;0.0187)		AAATGGGGCAACCTGGCCCAC	0.502			NA											4	53					0	0	0.009096	0	0
PID1	55022	broad.mit.edu	37	2	229890500	229890500	+	Nonsense_Mutation	SNP	C	C	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr2:229890500C>A	uc002vpr.3	-	3	639	c.601G>T	c.(601-603)GAG>TAG	p.E201*	PID1_uc002vps.3_Nonsense_Mutation_p.E199*|PID1_uc002vpt.3_Nonsense_Mutation_p.E168*|PID1_uc002vpu.3_Nonsense_Mutation_p.E119*	NM_001100818	NP_001094288	Q7Z2X4	PCLI1_HUMAN	phosphotyrosine interaction domain containing 1	201	PID.					cytoplasm				breast(3)|skin(1)	4		Renal(207;0.0112)|all_lung(227;0.0191)|Lung NSC(271;0.0851)|all_hematologic(139;0.104)|Acute lymphoblastic leukemia(138;0.171)		Epithelial(121;3.08e-11)|all cancers(144;2.28e-08)|LUSC - Lung squamous cell carcinoma(224;0.0145)|Lung(261;0.0189)		CTCTCGCACTCCACGGCGTGG	0.587			NA											15	150					1.49906e-05	1.74798e-05	0.00245	1	0
SP110	3431	broad.mit.edu	37	2	231036855	231036855	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr2:231036855C>A	uc002vqh.3	-	16	1982	c.1742G>T	c.(1741-1743)AGG>ATG	p.R581M	SP110_uc002vqg.3_Missense_Mutation_p.R581M	NM_004509	NP_004500	Q9HB58	SP110_HUMAN	SP110 nuclear body protein isoform a	581	Bromo.				interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|signal transducer activity|zinc ion binding			ovary(2)|breast(2)	4		Renal(207;0.0112)|all_lung(227;0.0223)|Lung NSC(271;0.0983)|all_hematologic(139;0.104)|Acute lymphoblastic leukemia(138;0.169)		Epithelial(121;2.61e-12)|all cancers(144;6.39e-10)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.0097)		TCCTGAAGACCTCTTCATCCT	0.547			NA											67	127					1.76847e-28	2.89054e-28	0.00361	1	0
SP140	11262	broad.mit.edu	37	2	231177387	231177387	+	Missense_Mutation	SNP	T	T	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr2:231177387T>A	uc002vql.2	+	27	2707	c.2592T>A	c.(2590-2592)AAT>AAA	p.N864K	SP140_uc010zma.1_Intron|SP140_uc002vqn.2_Missense_Mutation_p.N750K|SP140_uc002vqm.2_Missense_Mutation_p.N804K|SP140_uc010fxl.2_Missense_Mutation_p.N837K	NM_007237	NP_009168	Q13342	LY10_HUMAN	SP140 nuclear body protein isoform 1	864					defense response	cytoplasm|nuclear envelope|nucleolus|nucleoplasm	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Renal(207;0.0112)|all_lung(227;0.0221)|Lung NSC(271;0.0977)|all_hematologic(139;0.103)|Acute lymphoblastic leukemia(138;0.167)		Epithelial(121;1.13e-12)|all cancers(144;2.71e-10)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.00942)		AGGAAACAAATGGGAACAATT	0.239			NA											17	154					0	0	0.004007	0	0
CHRND	1144	broad.mit.edu	37	2	233399022	233399022	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr2:233399022C>A	uc002vsw.2	+	11	1345	c.1341C>A	c.(1339-1341)AAC>AAA	p.N447K	CHRND_uc010zmg.1_Missense_Mutation_p.N432K|CHRND_uc010fyc.2_Missense_Mutation_p.N320K|CHRND_uc010zmh.1_Missense_Mutation_p.N253K	NM_000751	NP_000742	Q07001	ACHD_HUMAN	nicotinic acetylcholine receptor delta	447	Cytoplasmic (Potential).				muscle contraction|musculoskeletal movement|neuromuscular process|skeletal muscle tissue growth|synaptic transmission	cell junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	nicotinic acetylcholine-activated cation-selective channel activity|receptor activity			ovary(1)|breast(1)|skin(1)	3		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;1.89e-16)|BRCA - Breast invasive adenocarcinoma(100;0.00078)|Lung(119;0.00579)|LUSC - Lung squamous cell carcinoma(224;0.00754)		TCATTGTTAACCACATGAGGG	0.502			NA											21	55					1.10923e-09	1.47898e-09	0.00278	1	0
SH3BP4	23677	broad.mit.edu	37	2	235951690	235951690	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr2:235951690G>T	uc002vvp.2	+	4	2670	c.2277G>T	c.(2275-2277)AGG>AGT	p.R759S	SH3BP4_uc010fym.2_Missense_Mutation_p.R759S|SH3BP4_uc002vvq.2_Missense_Mutation_p.R759S	NM_014521	NP_055336	Q9P0V3	SH3B4_HUMAN	SH3-domain binding protein 4	759					endocytosis	clathrin-coated vesicle|coated pit|nucleus	protein binding			skin(3)|ovary(1)	4		Breast(86;0.000332)|Renal(207;0.00339)|all_lung(227;0.00458)|all_hematologic(139;0.0296)|Lung NSC(271;0.0419)		Epithelial(121;7.66e-20)|BRCA - Breast invasive adenocarcinoma(100;0.000402)|Lung(119;0.00299)|LUSC - Lung squamous cell carcinoma(224;0.00645)|GBM - Glioblastoma multiforme(43;0.237)		CCTCCGTGAGGACCCTGCTCA	0.632			NA											12	56					2.62699e-14	3.82548e-14	0.003163	1	0
LRRFIP1	9208	broad.mit.edu	37	2	238672084	238672084	+	Silent	SNP	C	C	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr2:238672084C>T	uc002vxe.2	+	11	2020	c.1728C>T	c.(1726-1728)AAC>AAT	p.N576N	LRRFIP1_uc002vxc.2_Intron|LRRFIP1_uc010znm.1_Intron|LRRFIP1_uc002vxd.2_Silent_p.N552N|LRRFIP1_uc002vxf.2_Silent_p.N520N	NM_001137552	NP_001131024	Q32MZ4	LRRF1_HUMAN	leucine rich repeat (in FLII) interacting	576	DNA-binding.|Lys-rich.				negative regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|cytoskeleton|nucleus	DNA binding|double-stranded RNA binding|protein binding			breast(3)	3		Breast(86;0.00257)|Renal(207;0.00571)|Ovarian(221;0.17)|all_hematologic(139;0.182)		Epithelial(121;9.75e-23)|OV - Ovarian serous cystadenocarcinoma(60;1.01e-10)|Kidney(56;4.85e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.31e-07)|BRCA - Breast invasive adenocarcinoma(100;0.000151)|Lung(119;0.0137)|LUSC - Lung squamous cell carcinoma(224;0.0325)|COAD - Colon adenocarcinoma(134;0.228)		aaaagaaaaacaagaagaaaa	0.323			NA											12	76					0	0	0.001368	0	0
HDAC4	9759	broad.mit.edu	37	2	239974820	239974820	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr2:239974820C>A	uc002vyk.3	-	27	4020	c.3228G>T	c.(3226-3228)GAG>GAT	p.E1076D	HDAC4_uc010fyy.2_Missense_Mutation_p.E1033D	NM_006037	NP_006028	P56524	HDAC4_HUMAN	histone deacetylase 4	1076	Nuclear export signal (By similarity).|Histone deacetylase.				B cell differentiation|cardiac muscle hypertrophy in response to stress|chromatin remodeling|histone H3 deacetylation|histone H4 deacetylation|inflammatory response|negative regulation of glycolysis|negative regulation of myotube differentiation|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|nervous system development|peptidyl-lysine deacetylation|positive regulation of cell proliferation|positive regulation of protein sumoylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of protein binding|response to denervation involved in regulation of muscle adaptation|response to interleukin-1|transcription, DNA-dependent	histone deacetylase complex|transcriptional repressor complex	activating transcription factor binding|histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|potassium ion binding|repressing transcription factor binding|zinc ion binding			breast(3)|skin(2)|ovary(1)	6		all_epithelial(40;1.45e-17)|Breast(86;1.53e-05)|Renal(207;0.000355)|all_lung(227;0.0121)|Ovarian(221;0.0183)|Lung NSC(271;0.0413)|Melanoma(123;0.0749)|all_hematologic(139;0.159)		Epithelial(121;6.38e-25)|OV - Ovarian serous cystadenocarcinoma(60;2.48e-12)|Kidney(56;6.04e-08)|KIRC - Kidney renal clear cell carcinoma(57;1.18e-06)|BRCA - Breast invasive adenocarcinoma(100;3.99e-05)|Lung(119;0.00942)|LUSC - Lung squamous cell carcinoma(224;0.04)		CTTCCATGGGCTCCTCATCTG	0.567			NA											17	79					1.99824e-07	2.46017e-07	0.00499	1	0
KIF1A	547	broad.mit.edu	37	2	241727624	241727624	+	Silent	SNP	C	C	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr2:241727624C>A	uc002vzy.2	-	4	353	c.207G>T	c.(205-207)TCG>TCT	p.S69S	KIF1A_uc010fzk.2_Silent_p.S69S|KIF1A_uc002vzz.1_Silent_p.S69S	NM_004321	NP_004312	Q12756	KIF1A_HUMAN	axonal transport of synaptic vesicles	69	Kinesin-motor.				anterograde axon cargo transport	cytoplasm|microtubule|nucleus	ATP binding|microtubule motor activity			lung(1)	1		all_epithelial(40;1.35e-15)|Breast(86;2.14e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0295)|all_neural(83;0.0459)|Lung NSC(271;0.0942)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;6.12e-30)|all cancers(36;3.46e-27)|OV - Ovarian serous cystadenocarcinoma(60;1.38e-14)|Kidney(56;5e-09)|KIRC - Kidney renal clear cell carcinoma(57;5e-08)|BRCA - Breast invasive adenocarcinoma(100;5.87e-06)|Lung(119;0.00209)|LUSC - Lung squamous cell carcinoma(224;0.00902)|Colorectal(34;0.0282)|COAD - Colon adenocarcinoma(134;0.176)		CCTGCTTCTGCGACGCGTAGT	0.602			NA											7	21					0.000157383	0.000176986	0.00308	1	0
ANO7	50636	broad.mit.edu	37	2	242142826	242142826	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr2:242142826C>A	uc002wax.2	+	9	1067	c.964C>A	c.(964-966)CGC>AGC	p.R322S		NM_001001891	NP_001001891	Q6IWH7	ANO7_HUMAN	transmembrane protein 16G isoform NGEP long	322	Cytoplasmic (Potential).					cell junction|chloride channel complex|cytosol	chloride channel activity			pancreas(2)|central_nervous_system(1)	3						GCACTGGGCGCGCTGGGGCAA	0.687			NA											8	6					0.000274275	0.000305179	0.004482	1	0
SRXN1	140809	broad.mit.edu	37	20	629553	629553	+	Silent	SNP	T	T	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr20:629553T>A	uc002wea.2	-	2	280	c.219A>T	c.(217-219)CCA>CCT	p.P73P	SRXN1_uc002web.2_RNA	NM_080725	NP_542763	Q9BYN0	SRXN1_HUMAN	sulfiredoxin 1 homolog	73					response to oxidative stress	cytosol	antioxidant activity|ATP binding|DNA binding|sulfiredoxin activity			ovary(1)	1						GCACGCTGTCTGGGTCCTCCT	0.562			NA											4	48					0	0	0.009096	0	0
TGM6	343641	broad.mit.edu	37	20	2375141	2375141	+	Silent	SNP	C	C	G	rs147506152	by1000genomes	TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr20:2375141C>G	uc002wfy.1	+	2	112	c.51C>G	c.(49-51)GGC>GGG	p.G17G	TGM6_uc010gal.1_Silent_p.G17G	NM_198994	NP_945345	O95932	TGM3L_HUMAN	transglutaminase 6	17					cell death|peptide cross-linking		acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			ovary(3)|skin(1)	4					L-Glutamine(DB00130)	CGAGGAATGGCGCTGCCCACC	0.647			NA											4	30					0	0	0.009096	0	0
ADAM33	80332	broad.mit.edu	37	20	3652889	3652889	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr20:3652889G>T	uc002wit.2	-	14	1576	c.1489C>A	c.(1489-1491)CCA>ACA	p.P497T	ADAM33_uc002wiq.1_5'Flank|ADAM33_uc002wir.1_Missense_Mutation_p.P497T|ADAM33_uc002wis.2_Missense_Mutation_p.P19T|ADAM33_uc002wiu.2_Missense_Mutation_p.P497T|uc002wiv.1_5'Flank|ADAM33_uc002wiw.1_Intron|ADAM33_uc010gba.1_Intron|ADAM33_uc010gbb.1_Intron	NM_025220	NP_079496	Q9BZ11	ADA33_HUMAN	ADAM metallopeptidase domain 33 isoform alpha	497	Extracellular (Potential).|Disintegrin.				proteolysis	integral to membrane	metalloendopeptidase activity|zinc ion binding			large_intestine(2)|ovary(1)|skin(1)	4						TAAACGTCTGGGGGACAGTGG	0.657			NA											15	93					2.32078e-09	3.06421e-09	0.003163	1	0
ADRA1D	146	broad.mit.edu	37	20	4202311	4202311	+	Silent	SNP	C	C	G			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr20:4202311C>G	uc002wkr.2	-	2	1633	c.1578G>C	c.(1576-1578)GCG>GCC	p.A526A		NM_000678	NP_000669	P25100	ADA1D_HUMAN	alpha-1D-adrenergic receptor	526	Cytoplasmic (By similarity).			KPPSAFREWRLLGPFRRPTTQLRAKVSSLSHKIRAGGAQRA EAACAQRSEVEAVSLGVPHEVAEGATCQAYELADYSNLRET DI -> SHPAPSASGGCWGRSGDPRPSCAPKSPACRTRSPP GARSAQRQRAPSAQRWRLCP (in Ref. 1).	cell proliferation|cell-cell signaling|DNA metabolic process|G-protein signaling, coupled to cAMP nucleotide second messenger|multicellular organismal development|positive regulation of cell proliferation	integral to plasma membrane	alpha1-adrenergic receptor activity				0					Alfuzosin(DB00346)|Bethanidine(DB00217)|Dapiprazole(DB00298)|Debrisoquin(DB04840)|Doxazosin(DB00590)|Guanadrel Sulfate(DB00226)|Guanethidine(DB01170)|Methotrimeprazine(DB01403)|Norepinephrine(DB00368)|Promazine(DB00420)|Propericiazine(DB01608)|Propiomazine(DB00777)|Sertindole(DB06144)|Tamsulosin(DB00706)|Terazosin(DB01162)	CTGCGCGCTGCGCGCCCCCGG	0.726			NA											8	32					0	0	0.001368	0	0
RASSF2	9770	broad.mit.edu	37	20	4770302	4770302	+	Silent	SNP	G	G	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr20:4770302G>T	uc002wld.2	-	7	633	c.579C>A	c.(577-579)GTC>GTA	p.V193V	RASSF2_uc002wlc.2_RNA|RASSF2_uc002wle.2_RNA|RASSF2_uc002wlf.2_Silent_p.V193V|RASSF2_uc010gbh.2_5'Flank	NM_170774	NP_739580	P50749	RASF2_HUMAN	Ras association domain family 2	193	Ras-associating.				cell cycle|signal transduction	nucleus	protein binding			ovary(3)|lung(2)|large_intestine(1)	6						TGTTGATGCGGACGTTGGTGA	0.542	Melanoma(158;1891 3343 50738)		NA											15	49					6.31663e-08	7.95241e-08	0.003163	1	0
C20orf30	29058	broad.mit.edu	37	20	5081562	5081562	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr20:5081562C>A	uc002wll.2	-	5	704	c.238G>T	c.(238-240)GTT>TTT	p.V80F	C20orf30_uc010gbi.2_Intron|C20orf30_uc002wlk.2_Missense_Mutation_p.V143F|C20orf30_uc002wlm.2_Missense_Mutation_p.V80F|C20orf30_uc002wln.2_Missense_Mutation_p.V80F|C20orf30_uc002wlo.2_RNA	NM_001009924	NP_001009924	Q96A57	CT030_HUMAN	hypothetical protein LOC29058 isoform 2	80	Helical; (Potential).					integral to membrane					0						AGCACTGGAACGGCCCGGTCT	0.478			NA									OREG0025754	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	26	41					2.44723e-14	3.56919e-14	0.004656	1	0
TMX4	56255	broad.mit.edu	37	20	7963259	7963259	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr20:7963259C>T	uc002wmx.1	-	8	822	c.689G>A	c.(688-690)CGG>CAG	p.R230Q		NM_021156	NP_066979	Q9H1E5	TMX4_HUMAN	thioredoxin-related transmembrane protein 4	230	Glu-rich.				cell redox homeostasis|electron transport chain|transport	integral to membrane					0						CTCTGATCTCCGATTCTGCTC	0.294			NA											8	72					0	0	0.008291	0	0
PAK7	57144	broad.mit.edu	37	20	9546831	9546831	+	Silent	SNP	C	C	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr20:9546831C>A	uc002wnl.2	-	6	1736	c.1191G>T	c.(1189-1191)ACG>ACT	p.T397T	PAK7_uc002wnk.2_Silent_p.T397T|PAK7_uc002wnj.2_Silent_p.T397T|PAK7_uc010gby.1_Silent_p.T397T	NM_020341	NP_065074	Q9P286	PAK7_HUMAN	p21-activated kinase 7	397	Linker.						ATP binding|protein binding|protein serine/threonine kinase activity	p.T397K(2)		lung(11)|skin(5)|central_nervous_system(3)|ovary(2)|large_intestine(1)|stomach(1)	23			COAD - Colon adenocarcinoma(9;0.194)			GGTAGGAAGCCGTGGAGATGT	0.622			NA											6	165					0.00116845	0.00127467	0.001168	1	0
ANKRD5	63926	broad.mit.edu	37	20	10033801	10033801	+	Missense_Mutation	SNP	A	A	G			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr20:10033801A>G	uc002wno.2	+	9	2305	c.1912A>G	c.(1912-1914)AGA>GGA	p.R638G	uc002wnn.1_Intron|ANKRD5_uc002wnp.2_Missense_Mutation_p.R638G|ANKRD5_uc010gbz.2_Missense_Mutation_p.R449G	NM_022096	NP_071379	Q9NU02	ANKR5_HUMAN	ankyrin repeat domain protein 5	638	ANK 8.						calcium ion binding			ovary(1)|breast(1)	2						TGCTGATTATAGAATAATTGA	0.348			NA											5	210					0	0	0.001168	0	0
KIF16B	55614	broad.mit.edu	37	20	16488723	16488723	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr20:16488723C>A	uc002wpg.1	-	7	737	c.579G>T	c.(577-579)CAG>CAT	p.Q193H	KIF16B_uc010gch.1_Missense_Mutation_p.Q193H|KIF16B_uc010gci.1_Missense_Mutation_p.Q193H|KIF16B_uc010gcj.1_Missense_Mutation_p.Q193H	NM_024704	NP_078980	Q96L93	KI16B_HUMAN	kinesin-like motor protein C20orf23	193	Kinesin-motor.				cell communication|early endosome to late endosome transport|endoderm development|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|formation of primary germ layer|Golgi to endosome transport|microtubule-based movement|receptor catabolic process|regulation of receptor recycling	early endosome membrane|microtubule	ATP binding|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding|plus-end-directed microtubule motor activity			skin(2)|large_intestine(1)|central_nervous_system(1)|lung(1)|breast(1)|ovary(1)|kidney(1)	8						CACCATAATTCTGTACTAAAT	0.413			NA											6	291					8.12818e-05	9.27259e-05	0.001984	1	0
PLAGL2	5326	broad.mit.edu	37	20	30784356	30784356	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr20:30784356C>G	uc002wxn.2	-	3	1607	c.1390G>C	c.(1390-1392)GGG>CGG	p.G464R		NM_002657	NP_002648	Q9UPG8	PLAL2_HUMAN	pleiomorphic adenoma gene-like 2	464						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|skin(1)	2			UCEC - Uterine corpus endometrioid carcinoma (5;0.0241)			AGTGGTCCCCCAGCTCCTGGG	0.597	Colon(163;15 1893 11280 16306 47518)		NA											10	100					0	0	0.008291	0	0
CEP250	11190	broad.mit.edu	37	20	34060658	34060658	+	Splice_Site	SNP	T	T	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr20:34060658T>A	uc002xcm.2	+	13	1880	c.1209_splice	c.e13+2	p.Q403_splice	CEP250_uc010zve.1_Splice_Site|CEP250_uc010zvd.1_Splice_Site	NM_007186	NP_009117	Q9BV73	CP250_HUMAN	centrosomal protein 2						centriole-centriole cohesion|G2/M transition of mitotic cell cycle|protein localization|regulation of centriole-centriole cohesion	centriole|cilium|cytosol|microtubule basal body|perinuclear region of cytoplasm|protein complex	protein C-terminus binding|protein kinase binding			ovary(4)|central_nervous_system(1)	5	Lung NSC(9;0.00156)|all_lung(11;0.00243)		BRCA - Breast invasive adenocarcinoma(18;0.0106)			GCTGTGCAGGTAGGAACCCTC	0.512			NA											31	177					0	0	0.007291	0	0
RBM12	10137	broad.mit.edu	37	20	34241207	34241207	+	Missense_Mutation	SNP	A	A	G			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr20:34241207A>G	uc002xdq.2	-	3	2270	c.2038T>C	c.(2038-2040)TCA>CCA	p.S680P	CPNE1_uc010zvj.1_Intron|CPNE1_uc002xde.2_Intron|CPNE1_uc002xdf.2_Intron|CPNE1_uc002xdg.2_Intron|CPNE1_uc010gfi.2_Intron|CPNE1_uc010gfj.2_Intron|CPNE1_uc002xdh.2_Intron|CPNE1_uc002xdi.2_Intron|CPNE1_uc002xdj.2_Intron|CPNE1_uc002xdk.2_Intron|CPNE1_uc002xdl.2_Intron|CPNE1_uc002xdm.2_Intron|CPNE1_uc010gfk.1_Intron|CPNE1_uc002xdn.1_Intron|CPNE1_uc002xdo.1_Intron|CPNE1_uc002xdp.1_Intron|RBM12_uc002xdr.2_Missense_Mutation_p.S680P|RBM12_uc002xds.2_Missense_Mutation_p.S680P	NM_152838	NP_690051	Q9NTZ6	RBM12_HUMAN	RNA binding motif protein 12	680	Gly-rich.|Pro-rich.					nucleus	nucleotide binding|protein binding|RNA binding			ovary(3)	3	Lung NSC(9;0.00608)|all_lung(11;0.00918)		BRCA - Breast invasive adenocarcinoma(18;0.00953)			GTTATTGCTGAACCAGGCAGT	0.597			NA											32	69					0	0	0.009535	0	0
RBM12	10137	broad.mit.edu	37	20	34242230	34242230	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr20:34242230C>A	uc002xdq.2	-	3	1247	c.1015G>T	c.(1015-1017)GTA>TTA	p.V339L	CPNE1_uc010zvj.1_5'Flank|CPNE1_uc002xde.2_Intron|CPNE1_uc002xdf.2_Intron|CPNE1_uc002xdg.2_Intron|CPNE1_uc010gfi.2_Intron|CPNE1_uc010gfj.2_Intron|CPNE1_uc002xdh.2_Intron|CPNE1_uc002xdi.2_Intron|CPNE1_uc002xdj.2_Intron|CPNE1_uc002xdk.2_Intron|CPNE1_uc002xdl.2_Intron|CPNE1_uc002xdm.2_Intron|CPNE1_uc010gfk.1_Intron|CPNE1_uc002xdn.1_Intron|CPNE1_uc002xdo.1_Intron|CPNE1_uc002xdp.1_Intron|RBM12_uc002xdr.2_Missense_Mutation_p.V339L|RBM12_uc002xds.2_Missense_Mutation_p.V339L	NM_152838	NP_690051	Q9NTZ6	RBM12_HUMAN	RNA binding motif protein 12	339	RRM 1.					nucleus	nucleotide binding|protein binding|RNA binding			ovary(3)	3	Lung NSC(9;0.00608)|all_lung(11;0.00918)		BRCA - Breast invasive adenocarcinoma(18;0.00953)			TTTCGACCTACATGATCTTTC	0.398			NA											42	291					9.88483e-10	1.32356e-09	0.007835	1	0
C20orf152	140894	broad.mit.edu	37	20	34596240	34596240	+	Missense_Mutation	SNP	T	T	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr20:34596240T>A	uc002xes.1	+	9	1148	c.992T>A	c.(991-993)TTT>TAT	p.F331Y	C20orf152_uc002xer.1_Missense_Mutation_p.F331Y|C20orf152_uc010gfp.1_RNA			Q96M20	CT152_HUMAN	SubName: Full=C20orf152 protein;	331											0	Breast(12;0.00631)					ATGGAAAGATTTAAGGAATTC	0.398			NA											7	264					0	0	0.001984	0	0
C20orf24	55969	broad.mit.edu	37	20	35236149	35236149	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr20:35236149G>T	uc002xfq.2	+	2	334	c.146G>T	c.(145-147)CGA>CTA	p.R49L	C20orf24_uc002xfo.2_Missense_Mutation_p.R75L|C20orf24_uc002xfp.2_Missense_Mutation_p.R49L|C20orf24_uc002xft.2_RNA|C20orf24_uc002xfr.2_Missense_Mutation_p.R49L|C20orf24_uc002xfs.2_Missense_Mutation_p.R49L	NM_018840	NP_061328	Q9BUV8	CT024_HUMAN	RAB5-interacting protein isoform a	49							protein binding				0	Breast(12;0.114)	Myeloproliferative disorder(115;0.00878)				TACTGGTTCCGACAGATCATT	0.423			NA											20	170					1.10923e-09	1.47898e-09	0.00278	1	0
C20orf132	140699	broad.mit.edu	37	20	35783522	35783522	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr20:35783522C>G	uc010zvu.1	-	11	1139	c.1048G>C	c.(1048-1050)GCC>CCC	p.A350P	C20orf132_uc002xgk.2_Intron|C20orf132_uc002xgm.2_Missense_Mutation_p.A350P|C20orf132_uc002xgn.2_Intron	NM_152503	NP_689716	Q9H579	CT132_HUMAN	hypothetical protein LOC140699 isoform 1	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment											0		Myeloproliferative disorder(115;0.00878)				CTGGCCGTGGCCCGTTCCCGC	0.502			NA											9	157					0	0	0.008291	0	0
JPH2	57158	broad.mit.edu	37	20	42747215	42747215	+	Silent	SNP	C	C	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr20:42747215C>T	uc002xli.1	-	3	2091	c.1218G>A	c.(1216-1218)CTG>CTA	p.L406L		NM_020433	NP_065166	Q9BR39	JPH2_HUMAN	junctophilin 2 isoform 1	406	Ala-rich.|Cytoplasmic (Potential).				calcium ion transport into cytosol|regulation of ryanodine-sensitive calcium-release channel activity	integral to membrane|junctional sarcoplasmic reticulum membrane|plasma membrane					0		Myeloproliferative disorder(115;0.0122)	COAD - Colon adenocarcinoma(18;0.00189)			GGTTGGCAGCCAGGGCGGCCT	0.612			NA											20	182					0	0	0.00278	0	0
SLC2A10	81031	broad.mit.edu	37	20	45353679	45353679	+	Splice_Site	SNP	G	G	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr20:45353679G>T	uc002xsl.2	+	2	102	c.5_splice	c.e2-1	p.G2_splice		NM_030777	NP_110404	O95528	GTR10_HUMAN	solute carrier family 2 member 10							endomembrane system|integral to membrane|perinuclear region of cytoplasm|plasma membrane	D-glucose transmembrane transporter activity|sugar:hydrogen symporter activity			ovary(1)	1		Myeloproliferative disorder(115;0.0122)				TTGTTTTTTAGGCCACTCCCC	0.378			NA											14	136					0.00185496	0.00201663	0.001855	1	0
SLC2A10	81031	broad.mit.edu	37	20	45358027	45358027	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr20:45358027G>C	uc002xsl.2	+	4	1544	c.1447G>C	c.(1447-1449)GGA>CGA	p.G483R		NM_030777	NP_110404	O95528	GTR10_HUMAN	solute carrier family 2 member 10	483	Helical; Name=12; (Potential).					endomembrane system|integral to membrane|perinuclear region of cytoplasm|plasma membrane	D-glucose transmembrane transporter activity|sugar:hydrogen symporter activity			ovary(1)	1		Myeloproliferative disorder(115;0.0122)				CCTGCTCTACGGACTGACCGC	0.582			NA											11	123					0	0	0.000978	0	0
SULF2	55959	broad.mit.edu	37	20	46305851	46305851	+	Silent	SNP	G	G	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr20:46305851G>T	uc002xto.2	-	9	1551	c.1221C>A	c.(1219-1221)GTC>GTA	p.V407V	SULF2_uc002xtr.2_Silent_p.V407V|SULF2_uc002xtq.2_Silent_p.V407V	NM_018837	NP_061325	Q8IWU5	SULF2_HUMAN	sulfatase 2 isoform a precursor	407					bone development|heparan sulfate proteoglycan metabolic process|kidney development|negative regulation of fibroblast growth factor receptor signaling pathway	cell surface|endoplasmic reticulum|extracellular space|Golgi stack	arylsulfatase activity|calcium ion binding			ovary(2)|breast(2)|pancreas(1)|skin(1)	6						AGTCCCGCCAGACCCTCATCT	0.612			NA											26	99					1.4374e-25	2.32932e-25	0.00361	1	0
SALL4	57167	broad.mit.edu	37	20	50408003	50408003	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr20:50408003C>T	uc002xwh.3	-	2	1120	c.1019G>A	c.(1018-1020)GGC>GAC	p.G340D	SALL4_uc010gii.2_Missense_Mutation_p.G340D|SALL4_uc002xwi.3_Intron	NM_020436	NP_065169	Q9UJQ4	SALL4_HUMAN	sal-like 4	340					transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2						GAGCACCGAGCCCGGGGCCTG	0.637			NA											5	108					0	0	0.000602	0	0
ZNF831	128611	broad.mit.edu	37	20	57766576	57766576	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr20:57766576G>T	uc002yan.2	+	1	502	c.502G>T	c.(502-504)GGT>TGT	p.G168C		NM_178457	NP_848552	Q5JPB2	ZN831_HUMAN	zinc finger protein 831	168						intracellular	nucleic acid binding|zinc ion binding			skin(13)|ovary(1)	14	all_lung(29;0.0085)					GTCCCACACGGGTGAGAGGCC	0.617			NA											19	264					4.96729e-08	6.27865e-08	0.008871	1	0
DIDO1	11083	broad.mit.edu	37	20	61542867	61542867	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr20:61542867G>A	uc002ydr.1	-	3	362	c.98C>T	c.(97-99)ACT>ATT	p.T33I	DIDO1_uc002yds.1_Missense_Mutation_p.T33I|DIDO1_uc002ydt.1_Missense_Mutation_p.T33I|DIDO1_uc002ydu.1_Missense_Mutation_p.T33I|DIDO1_uc002ydv.1_Missense_Mutation_p.T33I|DIDO1_uc002ydw.1_Missense_Mutation_p.T33I|DIDO1_uc002ydx.1_Missense_Mutation_p.T33I|DIDO1_uc011aao.1_Missense_Mutation_p.T33I	NM_033081	NP_149072	Q9BTC0	DIDO1_HUMAN	death inducer-obliterator 1 isoform c	33					apoptosis|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			ovary(3)|skin(3)	6	Breast(26;5.68e-08)					CTTGGCGATAGTGGTCCTTCG	0.632	Melanoma(25;381 482 3385 5362 7955 17159 17174 40604 47095)		NA											4	27					0	0	0.000602	0	0
CHRNA4	1137	broad.mit.edu	37	20	61990962	61990962	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr20:61990962C>A	uc002yes.2	-	2	344	c.166G>T	c.(166-168)GCC>TCC	p.A56S	CHRNA4_uc002yet.1_Intron|CHRNA4_uc011aaw.1_RNA|CHRNA4_uc010gke.1_5'UTR|CHRNA4_uc002yev.1_5'UTR|CHRNA4_uc010gkf.1_5'UTR	NM_000744	NP_000735	P43681	ACHA4_HUMAN	cholinergic receptor, nicotinic, alpha 4 subunit	56	Extracellular (Potential).				B cell activation|behavioral response to nicotine|calcium ion transport|cognition|DNA repair|membrane depolarization|regulation of action potential|regulation of dopamine secretion|regulation of inhibitory postsynaptic membrane potential|response to hypoxia|response to oxidative stress|sensory perception of pain|synaptic transmission, cholinergic	cell junction|dendrite|external side of plasma membrane|membrane fraction|neuronal cell body|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity			central_nervous_system(1)|skin(1)	2	all_cancers(38;1.71e-10)				Nicotine(DB00184)|Varenicline(DB01273)	GAGATGTTGGCCACGGGTCGG	0.637			NA											14	90					0.000151284	0.000171758	0.001855	1	0
CHRNA4	1137	broad.mit.edu	37	20	61991018	61991018	+	Missense_Mutation	SNP	T	T	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr20:61991018T>A	uc002yes.2	-	2	288	c.110A>T	c.(109-111)GAG>GTG	p.E37V	CHRNA4_uc002yet.1_Intron|CHRNA4_uc011aaw.1_RNA|CHRNA4_uc010gke.1_5'UTR|CHRNA4_uc002yev.1_5'UTR|CHRNA4_uc010gkf.1_5'UTR	NM_000744	NP_000735	P43681	ACHA4_HUMAN	cholinergic receptor, nicotinic, alpha 4 subunit	37	Extracellular (Potential).				B cell activation|behavioral response to nicotine|calcium ion transport|cognition|DNA repair|membrane depolarization|regulation of action potential|regulation of dopamine secretion|regulation of inhibitory postsynaptic membrane potential|response to hypoxia|response to oxidative stress|sensory perception of pain|synaptic transmission, cholinergic	cell junction|dendrite|external side of plasma membrane|membrane fraction|neuronal cell body|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity			central_nervous_system(1)|skin(1)	2	all_cancers(38;1.71e-10)				Nicotine(DB00184)|Varenicline(DB01273)	GAGCCGCTCCTCGGCGTGGGC	0.667			NA											8	61					0	0	0.000978	0	0
ZBTB46	140685	broad.mit.edu	37	20	62421331	62421331	+	Silent	SNP	A	A	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr20:62421331A>T	uc002ygv.1	-	2	981	c.780T>A	c.(778-780)GCT>GCA	p.A260A	ZBTB46_uc002ygu.2_RNA	NM_025224	NP_079500	Q86UZ6	ZBT46_HUMAN	zinc finger and BTB domain containing 46	260					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			large_intestine(1)|ovary(1)	2	all_cancers(38;2.09e-12)|all_epithelial(29;3.8e-14)|Lung NSC(23;7.61e-10)|all_lung(23;2.64e-09)					AGGCATCACCAGCACTCTGCT	0.577			NA											12	114					0	0	0.001368	0	0
TPTE	7179	broad.mit.edu	37	21	10920156	10920156	+	Silent	SNP	C	C	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr21:10920156C>A	uc002yip.1	-	19	1466	c.1098G>T	c.(1096-1098)CTG>CTT	p.L366L	TPTE_uc002yis.1_RNA|TPTE_uc002yiq.1_Silent_p.L348L|TPTE_uc002yir.1_Silent_p.L328L|TPTE_uc010gkv.1_Silent_p.L228L	NM_199261	NP_954870	P56180	TPTE_HUMAN	transmembrane phosphatase with tensin homology	366	Phosphatase tensin-type.				signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(2)|lung(1)|breast(1)|skin(1)	5			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		CAAAATAATACAGGCTTTCCT	0.383			NA											6	94					0.00116845	0.00127467	0.001168	1	0
TMPRSS15	5651	broad.mit.edu	37	21	19685299	19685299	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr21:19685299G>T	uc002ykw.2	-	18	2159	c.2128C>A	c.(2128-2130)CAG>AAG	p.Q710K		NM_002772	NP_002763	P98073	ENTK_HUMAN	enterokinase precursor	710	Extracellular (Potential).|SRCR.				proteolysis	brush border|integral to membrane	scavenger receptor activity|serine-type endopeptidase activity			ovary(5)|upper_aerodigestive_tract(1)|breast(1)|skin(1)	8						TTTGAAATCTGGGTGGTCCAG	0.338			NA											23	60					9.57634e-11	1.31762e-10	0.00333	1	0
KRTAP15-1	254950	broad.mit.edu	37	21	31813044	31813044	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr21:31813044G>T	uc002yod.2	+	1	399	c.399G>T	c.(397-399)CAG>CAT	p.Q133H		NM_181623	NP_853654	Q3LI76	KR151_HUMAN	keratin associated protein 15-1	133						intermediate filament					0						GGAATTTCCAGGCAACTTGTT	0.458			NA											34	88					9.8876e-21	1.54168e-20	0.004878	1	0
IL10RB	3588	broad.mit.edu	37	21	34640770	34640770	+	Nonsense_Mutation	SNP	G	G	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr21:34640770G>T	uc002yrk.1	+	2	220	c.121G>T	c.(121-123)GAG>TAG	p.E41*	IL10RB_uc002yrh.1_Nonsense_Mutation_p.E111*|IL10RB_uc002yri.1_Intron|uc002yrj.1_5'Flank|IL10RB_uc002yrl.1_Nonsense_Mutation_p.E43*	NM_000628	NP_000619	Q08334	I10R2_HUMAN	interleukin 10 receptor, beta precursor	41	Extracellular (Potential).				immune response|inflammatory response	interleukin-28 receptor complex	protein binding|receptor activity				0						TCTACAGTGGGAGTCACCTGC	0.458	Melanoma(67;315 1275 21667 21943 44564)		NA											13	53					5.50884e-06	6.51169e-06	0.001368	1	0
DYRK1A	1859	broad.mit.edu	37	21	38853123	38853123	+	Nonsense_Mutation	SNP	G	G	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr21:38853123G>T	uc002ywk.2	+	4	586	c.511G>T	c.(511-513)GGA>TGA	p.G171*	DYRK1A_uc002ywh.1_Nonsense_Mutation_p.G133*|DYRK1A_uc002ywi.2_Nonsense_Mutation_p.G171*|DYRK1A_uc002ywj.2_Nonsense_Mutation_p.G162*|DYRK1A_uc002ywl.2_Nonsense_Mutation_p.G171*|DYRK1A_uc002ywm.2_Nonsense_Mutation_p.G171*	NM_001396	NP_001387	Q13627	DYR1A_HUMAN	dual-specificity tyrosine-(Y)-phosphorylation	171	ATP (By similarity).|Protein kinase.				nervous system development|peptidyl-tyrosine phosphorylation|protein autophosphorylation	nuclear speck	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding|protein self-association|protein serine/threonine kinase activity			ovary(2)|lung(1)|breast(1)	4						AGGTTCCTTTGGACAGGTAAT	0.333	Melanoma(114;464 1602 31203 43785 45765)		NA											15	42					1.99824e-07	2.46017e-07	0.00499	1	0
TRPM2	7226	broad.mit.edu	37	21	45833845	45833845	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr21:45833845G>T	uc002zet.1	+	21	3247	c.3034G>T	c.(3034-3036)GAC>TAC	p.D1012Y	TRPM2_uc002zeu.1_Missense_Mutation_p.D1012Y|TRPM2_uc002zew.1_Missense_Mutation_p.D1012Y|TRPM2_uc010gpt.1_Missense_Mutation_p.D1012Y|TRPM2_uc002zex.1_Missense_Mutation_p.D798Y|TRPM2_uc002zey.1_Missense_Mutation_p.D525Y	NM_003307	NP_003298	O94759	TRPM2_HUMAN	transient receptor potential cation channel,	1012	Extracellular (Potential).					integral to plasma membrane	ADP-ribose diphosphatase activity|calcium channel activity|sodium channel activity			ovary(1)|central_nervous_system(1)|pancreas(1)	3						CCCCGAGAGCGACGCGACGCA	0.627			NA											45	324					2.76378e-25	4.4711e-25	0.00361	1	0
COL6A1	1291	broad.mit.edu	37	21	47421898	47421898	+	Silent	SNP	G	G	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr21:47421898G>A	uc002zhu.1	+	31	2082	c.1980G>A	c.(1978-1980)GCG>GCA	p.A660A	COL6A1_uc010gqd.1_5'UTR|COL6A1_uc002zhv.1_5'UTR|COL6A1_uc002zhw.1_5'Flank	NM_001848	NP_001839	P12109	CO6A1_HUMAN	collagen, type VI, alpha 1 precursor	660	VWFA 2.|C-terminal globular domain.				axon guidance|cell adhesion|protein heterotrimerization	collagen type VI|protein complex	platelet-derived growth factor binding			ovary(1)	1	all_hematologic(128;0.24)			Colorectal(79;0.0265)|READ - Rectum adenocarcinoma(84;0.0649)	Palifermin(DB00039)	AGTCGTACGCGGGTGTGGTGC	0.652			NA											3	19					0	0	0.000602	0	0
KLHL22	84861	broad.mit.edu	37	22	20819222	20819222	+	Silent	SNP	C	C	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr22:20819222C>A	uc002zsl.1	-	4	1144	c.1035G>T	c.(1033-1035)GCG>GCT	p.A345A	KLHL22_uc011ahr.1_Silent_p.A202A|KLHL22_uc002zsm.1_Silent_p.A345A	NM_032775	NP_116164	Q53GT1	KLH22_HUMAN	kelch-like	345	Kelch 1.				cell division	Cul3-RING ubiquitin ligase complex				lung(1)	1	Melanoma(16;0.000465)|Ovarian(15;0.00167)|Colorectal(54;0.0221)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.00102)|Lung(15;0.0173)			TGTTGAGCACCGCGATGCCCT	0.567			NA											42	143					5.34276e-22	8.44155e-22	0.00361	1	0
SMTN	6525	broad.mit.edu	37	22	31484883	31484883	+	Silent	SNP	C	C	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr22:31484883C>T	uc003ajl.1	+	6	617	c.399C>T	c.(397-399)TAC>TAT	p.Y133Y	SMTN_uc003ajk.1_Silent_p.Y133Y|SMTN_uc003ajm.1_Silent_p.Y133Y|SMTN_uc011ale.1_Silent_p.Y187Y|SMTN_uc011alf.1_Silent_p.Y189Y|SMTN_uc003ajn.1_Silent_p.Y125Y|SMTN_uc011alg.1_5'Flank	NM_006932	NP_008863	P53814	SMTN_HUMAN	smoothelin isoform c	133					muscle organ development|smooth muscle contraction	actin cytoskeleton|cytoplasm	actin binding|structural constituent of muscle			large_intestine(2)|pancreas(1)	3						GGAGGTTGTACAGCGGGCGTC	0.632			NA									OREG0026472	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	9	35					0	0	0.000978	0	0
SYN3	8224	broad.mit.edu	37	22	33260911	33260911	+	Silent	SNP	A	A	G			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr22:33260911A>G	uc003amx.2	-	5	861	c.702T>C	c.(700-702)CAT>CAC	p.H234H	SYN3_uc003amy.2_Silent_p.H234H|SYN3_uc003amz.2_Silent_p.H233H	NM_003490	NP_003481	O14994	SYN3_HUMAN	synapsin III isoform IIIa	234	C; actin-binding and synaptic-vesicle binding.				neurotransmitter secretion	cell junction|synaptic vesicle membrane	ATP binding|ligase activity			skin(1)	1						CCATTGGCTTATGGTTGGGGA	0.463			NA											50	224					0	0	0.00361	0	0
HMOX1	3162	broad.mit.edu	37	22	35779116	35779116	+	Nonsense_Mutation	SNP	C	C	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr22:35779116C>A	uc003ant.1	+	2	121	c.41C>A	c.(40-42)TCA>TAA	p.S14*		NM_002133	NP_002124	P09601	HMOX1_HUMAN	heme oxygenase (decyclizing) 1	14					angiogenesis|anti-apoptosis|cell death|cellular iron ion homeostasis|endothelial cell proliferation|erythrocyte homeostasis|heme catabolic process|heme oxidation|intracellular protein kinase cascade|low-density lipoprotein particle clearance|negative regulation of leukocyte migration|negative regulation of smooth muscle cell proliferation|positive regulation of chemokine biosynthetic process|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of smooth muscle cell proliferation|protein homooligomerization|regulation of transcription from RNA polymerase II promoter in response to oxidative stress|response to hydrogen peroxide|response to nicotine|smooth muscle hyperplasia|transmembrane transport|wound healing involved in inflammatory response	endoplasmic reticulum membrane|extracellular space|microsome	enzyme binding|heme binding|heme oxygenase (decyclizing) activity|protein homodimerization activity|signal transducer activity			ovary(1)	1					NADH(DB00157)	CAGGATTTGTCAGAGGCCCTG	0.592			NA											11	68					0.00010058	0.000114465	0.001368	1	0
CSF2RB	1439	broad.mit.edu	37	22	37326508	37326508	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr22:37326508C>A	uc003aqa.3	+	7	1027	c.810C>A	c.(808-810)AGC>AGA	p.S270R	CSF2RB_uc003aqc.3_Missense_Mutation_p.S270R	NM_000395	NP_000386	P32927	IL3RB_HUMAN	colony stimulating factor 2 receptor, beta	270	Extracellular (Potential).				respiratory gaseous exchange	granulocyte macrophage colony-stimulating factor receptor complex	cytokine receptor activity			skin(2)|pancreas(1)	3					Sargramostim(DB00020)	AGGTGGCCAGCTCGGTCTCCT	0.617			NA											6	160					0.00198382	0.00213469	0.001984	1	0
TAB1	10454	broad.mit.edu	37	22	39822870	39822870	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr22:39822870G>T	uc003axt.2	+	9	1133	c.1084G>T	c.(1084-1086)GTG>TTG	p.V362L	TAB1_uc003axr.2_Missense_Mutation_p.V438L|TAB1_uc011aok.1_Missense_Mutation_p.V196L|TAB1_uc003axu.1_Missense_Mutation_p.V362L	NM_006116	NP_006107	Q15750	TAB1_HUMAN	mitogen-activated protein kinase kinase kinase 7	362	PP2C-like.				activation of MAPK activity|activation of MAPKKK activity|I-kappaB kinase/NF-kappaB cascade|innate immune response|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of NF-kappaB transcription factor activity|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|endosome membrane	catalytic activity|protein binding			breast(1)	1						GACCCTGCTAGTGAGGAACTT	0.662			NA											4	107					1.024e-07	1.27899e-07	0.000602	1	0
ENTHD1	150350	broad.mit.edu	37	22	40283548	40283548	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr22:40283548G>A	uc003ayg.2	-	2	456	c.205C>T	c.(205-207)CGC>TGC	p.R69C		NM_152512	NP_689725	Q8IYW4	ENTD1_HUMAN	ENTH domain containing 1	69	ENTH.									ovary(2)|skin(1)	3	Melanoma(58;0.0749)					TACACGTGGCGCCAGTTCTTC	0.403			NA											6	248					0	0	0.001984	0	0
PKDREJ	10343	broad.mit.edu	37	22	46656286	46656286	+	Silent	SNP	C	C	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr22:46656286C>T	uc003bhh.2	-	1	2934	c.2934G>A	c.(2932-2934)TTG>TTA	p.L978L		NM_006071	NP_006062	Q9NTG1	PKDRE_HUMAN	receptor for egg jelly-like protein precursor	978	Extracellular (Potential).				acrosome reaction|neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity			breast(3)|ovary(2)	5		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00459)		TCGTCTTCTTCAAGGACCCAT	0.483			NA											40	134					0	0	0.00623	0	0
GTSE1	51512	broad.mit.edu	37	22	46708079	46708079	+	Silent	SNP	C	C	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr22:46708079C>T	uc011aqy.1	+	5	1016	c.804C>T	c.(802-804)ATC>ATT	p.I268I	GTSE1_uc011aqz.1_Silent_p.I115I	NM_016426	NP_057510	Q9NYZ3	GTSE1_HUMAN	G-2 and S-phase expressed 1	249					DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G2 phase of mitotic cell cycle|microtubule-based process	cytoplasmic microtubule				ovary(1)	1		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00462)		GGACAAAAATCCCAGCTGAGA	0.512	GBM(153;542 1915 12487 29016 50495)		NA											12	37					0	0	0.001368	0	0
BRPF1	7862	broad.mit.edu	37	3	9788023	9788023	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr3:9788023C>T	uc003bse.2	+	13	3745	c.3346C>T	c.(3346-3348)CAT>TAT	p.H1116Y	BRPF1_uc003bsf.2_Missense_Mutation_p.H1122Y|BRPF1_uc003bsg.2_Missense_Mutation_p.H1115Y|BRPF1_uc011ati.1_Missense_Mutation_p.H1021Y	NM_004634	NP_004625	P55201	BRPF1_HUMAN	bromodomain and PHD finger-containing protein 1	1116	PWWP.				histone H3 acetylation|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|MOZ/MORF histone acetyltransferase complex|plasma membrane	DNA binding|zinc ion binding			ovary(2)|central_nervous_system(1)	3	Medulloblastoma(99;0.227)					TATGTTCCACCATGGGGTTCC	0.527			NA											33	116					0	0	0.003755	0	0
HDAC11	79885	broad.mit.edu	37	3	13545601	13545601	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr3:13545601C>G	uc003bxy.2	+	9	790	c.657C>G	c.(655-657)ATC>ATG	p.I219M	HDAC11_uc010heb.2_Nonsense_Mutation_p.S177*|HDAC11_uc011aux.1_Missense_Mutation_p.I27M|HDAC11_uc011auy.1_Missense_Mutation_p.I168M	NM_024827	NP_079103	Q96DB2	HDA11_HUMAN	histone deacetylase 11 isoform 1	219	Histone deacetylase.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	histone deacetylase complex|plasma membrane	histone deacetylase activity (H3-K16 specific)|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|transcription factor binding			ovary(2)	2						cagagGCCATCAGGCGGAAGG	0.318			NA											3	19					0	0	0.009096	0	0
DCLK3	85443	broad.mit.edu	37	3	36763072	36763072	+	Missense_Mutation	SNP	A	A	G			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr3:36763072A>G	uc003cgi.2	-	3	2022	c.1531T>C	c.(1531-1533)TTT>CTT	p.F511L		NM_033403	NP_208382	Q9C098	DCLK3_HUMAN	doublecortin-like kinase 3	511	Protein kinase.					cytoplasm|nucleus	ATP binding|protein serine/threonine kinase activity			lung(3)|large_intestine(2)|breast(1)|skin(1)|ovary(1)|kidney(1)	9						CACACAGTAAATATAGGTCTC	0.428			NA											5	126					0	0	0.000602	0	0
SLC22A13	9390	broad.mit.edu	37	3	38307398	38307398	+	Missense_Mutation	SNP	G	G	C	rs72542450	byFrequency	TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr3:38307398G>C	uc003chz.3	+	1	101	c.47G>C	c.(46-48)CGC>CCC	p.R16P	SLC22A13_uc011aym.1_RNA|SLC22A13_uc011ayn.1_Missense_Mutation_p.R16P	NM_004256	NP_004247	Q9Y226	S22AD_HUMAN	solute carrier family 22 (organic anion	16	Cytoplasmic (Potential).					integral to plasma membrane	organic cation transmembrane transporter activity			skin(1)	1				KIRC - Kidney renal clear cell carcinoma(284;0.0533)|Kidney(284;0.067)		GACTTTGGTCGCTTCCAGATA	0.507			NA											5	79					0	0	0.000602	0	0
CCR8	1237	broad.mit.edu	37	3	39374243	39374244	+	Missense_Mutation	DNP	GC	GC	AA			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	GC	GC	-	-	GC	GC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr3:39374243_39374244GC>AA	uc010hhr.2	+	2	559_560	c.421_422GC>AA	c.(421-423)GCC>AAC	p.A141N	CCR8_uc003cjm.2_Missense_Mutation_p.A58N	NM_005201	NP_005192	P51685	CCR8_HUMAN	chemokine (C-C motif) receptor 8	141	Cytoplasmic (Potential).				cell adhesion|chemotaxis|elevation of cytosolic calcium ion concentration|immune response	integral to plasma membrane	coreceptor activity			ovary(1)|lung(1)	2				KIRC - Kidney renal clear cell carcinoma(284;0.0504)|Kidney(284;0.0635)		TGCCGTGTATGCCCTAAAGGTG	0.5			NA											37	251					0	0	0.004672	0	0
ZNF501	115560	broad.mit.edu	37	3	44776034	44776034	+	Nonsense_Mutation	SNP	C	C	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr3:44776034C>T	uc003cnu.1	+	3	522	c.121C>T	c.(121-123)CAG>TAG	p.Q41*	ZNF501_uc003cnv.1_Nonsense_Mutation_p.Q41*	NM_145044	NP_659481	Q96CX3	ZN501_HUMAN	zinc finger protein 501	41	C2H2-type 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				BRCA - Breast invasive adenocarcinoma(193;0.00843)|KIRC - Kidney renal clear cell carcinoma(197;0.0463)|Kidney(197;0.0579)		TACCCAGCACCAGAGGATTCA	0.423			NA											11	61					0	0	0.000978	0	0
TGM4	7047	broad.mit.edu	37	3	44951615	44951615	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr3:44951615C>T	uc003coc.3	+	11	1434	c.1361C>T	c.(1360-1362)GCC>GTC	p.A454V		NM_003241	NP_003232	P49221	TGM4_HUMAN	transglutaminase 4 (prostate)	454					peptide cross-linking|protein polyamination		acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.00963)|KIRC - Kidney renal clear cell carcinoma(197;0.0546)|Kidney(197;0.0686)	L-Glutamine(DB00130)	ATGGATCATGCCTTCCTCCTT	0.507			NA											9	40					0	0	0.006214	0	0
PTH1R	5745	broad.mit.edu	37	3	46945140	46945140	+	Silent	SNP	C	C	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr3:46945140C>A	uc003cqm.2	+	16	1979	c.1776C>A	c.(1774-1776)GTC>GTA	p.V592V	PTH1R_uc003cqn.2_Silent_p.V592V	NM_000316	NP_000307	Q03431	PTH1R_HUMAN	parathyroid hormone receptor 1 precursor	592	Cytoplasmic (Potential).					cytoplasm|integral to plasma membrane|nucleus	parathyroid hormone receptor activity|peptide hormone binding|protein self-association			breast(1)	1						GGGAGACAGTCATGTGACCAG	0.612			NA							Ollier_disease_/_Maffucsyndrome				22	107					3.6726e-16	5.47426e-16	0.003954	1	0
QARS	5859	broad.mit.edu	37	3	49138082	49138082	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr3:49138082C>T	uc003cvx.2	-	11	907	c.902G>A	c.(901-903)CGT>CAT	p.R301H	QARS_uc011bcc.1_5'Flank|QARS_uc011bcd.1_Missense_Mutation_p.R156H|QARS_uc003cvy.2_Missense_Mutation_p.R156H|QARS_uc011bce.1_Missense_Mutation_p.R290H|QARS_uc011bcf.1_3'UTR	NM_005051	NP_005042	P47897	SYQ_HUMAN	glutaminyl-tRNA synthetase	301					glutaminyl-tRNA aminoacylation	cytosol|mitochondrial matrix	ATP binding|glutamine-tRNA ligase activity|protein binding			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00219)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)	L-Glutamine(DB00130)	GTCATCAAAACGCAGAAAACA	0.478			NA											4	101					0	0	0.009096	0	0
NISCH	11188	broad.mit.edu	37	3	52505828	52505828	+	Splice_Site	SNP	A	A	G			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr3:52505828A>G	uc011beg.1	+	6	482	c.410_splice	c.e6-2	p.G137_splice	NISCH_uc003ded.3_Splice_Site_p.G137_splice|NISCH_uc003dec.1_Splice_Site_p.G137_splice	NM_007184	NP_009115	Q9Y2I1	NISCH_HUMAN	nischarin						apoptosis|cell communication	cytosol|early endosome|plasma membrane|recycling endosome	phosphatidylinositol binding|receptor activity			ovary(3)|central_nervous_system(1)	4				BRCA - Breast invasive adenocarcinoma(193;1.93e-05)|Kidney(197;0.00216)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)|OV - Ovarian serous cystadenocarcinoma(275;0.0577)		TGGCTCTTGCAGGAGAACAGC	0.617			NA											8	23					0	0	0.006214	0	0
LMOD3	56203	broad.mit.edu	37	3	69168667	69168667	+	Missense_Mutation	SNP	T	T	C			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr3:69168667T>C	uc003dns.2	-	2	1048	c.839A>G	c.(838-840)AAA>AGA	p.K280R	LMOD3_uc003dnt.2_Missense_Mutation_p.K280R	NM_198271	NP_938012	Q0VAK6	LMOD3_HUMAN	leiomodin 3 (fetal)	280						cytoplasm|cytoskeleton	tropomyosin binding			ovary(1)	1		Lung NSC(201;0.0193)|Prostate(884;0.174)		BRCA - Breast invasive adenocarcinoma(55;7.88e-05)|Epithelial(33;0.000839)|LUSC - Lung squamous cell carcinoma(21;0.0119)|Lung(16;0.0191)|KIRC - Kidney renal clear cell carcinoma(39;0.205)|Kidney(39;0.24)		GTGCTTGTTTTTCTTCATTGC	0.388			NA											21	127					0	0	0.001882	0	0
POU1F1	5449	broad.mit.edu	37	3	87325585	87325585	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr3:87325585C>A	uc003dqq.1	-	1	153	c.28G>T	c.(28-30)GAT>TAT	p.D10Y	POU1F1_uc010hoj.1_Missense_Mutation_p.D10Y	NM_000306	NP_000297	P28069	PIT1_HUMAN	pituitary specific transcription factor 1	10					negative regulation of cell proliferation|positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|skin(1)	2	all_cancers(8;0.104)|Lung SC(3;0.184)	Lung NSC(201;0.0777)		LUSC - Lung squamous cell carcinoma(29;0.00229)|Lung(72;0.00677)		ATAAAGGTATCAGCCGAAGTA	0.448			NA											10	56					1.76689e-08	2.2666e-08	0.006214	1	0
C3orf38	285237	broad.mit.edu	37	3	88202561	88202561	+	Silent	SNP	G	G	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr3:88202561G>A	uc003dqw.2	+	3	626	c.315G>A	c.(313-315)CTG>CTA	p.L105L		NM_173824	NP_776185	Q5JPI3	CC038_HUMAN	hypothetical protein LOC285237	105					apoptosis						0		Lung NSC(201;0.17)		UCEC - Uterine corpus endometrioid carcinoma (27;0.194)|LUSC - Lung squamous cell carcinoma(29;0.00353)|Lung(72;0.00661)		AACCACAACTGAAATTGAAGG	0.383			NA											62	90					0	0	0.00361	0	0
EPHA6	285220	broad.mit.edu	37	3	96963115	96963115	+	Silent	SNP	G	G	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr3:96963115G>T	uc010how.1	+	5	1633	c.1590G>T	c.(1588-1590)GTG>GTT	p.V530V	EPHA6_uc003drp.1_Silent_p.V530V	NM_001080448	NP_001073917	Q9UF33	EPHA6_HUMAN	EPH receptor A6 isoform a	435	Extracellular (Potential).					integral to plasma membrane	ATP binding|ephrin receptor activity	p.V436V(1)		stomach(5)|lung(4)|central_nervous_system(3)|breast(1)|skin(1)|ovary(1)|kidney(1)	16						CTATTACAGTGACCACGGATC	0.388			NA											8	64					9.70103e-10	1.30079e-09	0.008291	1	0
OR5H14	403273	broad.mit.edu	37	3	97868307	97868308	+	Silent	DNP	CC	CC	AT	rs146669592		TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr3:97868307_97868308CC>AT	uc003dsg.1	+	1	78_79	c.78_79CC>AT	c.(76-81)CCCCTG>CCATTG	p.26_27PL>PL		NM_001005514	NP_001005514	A6NHG9	O5H14_HUMAN	olfactory receptor, family 5, subfamily H,	26_27	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						GGAAAATACCCCTGTTCCTGGC	0.416			NA											43	270					0	0	0.004672	0	0
OR5H15	403274	broad.mit.edu	37	3	97887756	97887756	+	Silent	SNP	T	T	C			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr3:97887756T>C	uc011bgu.1	+	1	213	c.213T>C	c.(211-213)GCT>GCC	p.A71A		NM_001005515	NP_001005515	A6NDH6	O5H15_HUMAN	olfactory receptor, family 5, subfamily H,	71	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						TTGTGGATGCTTGGATATCAT	0.403			NA											39	152					0	0	0.00361	0	0
NIT2	56954	broad.mit.edu	37	3	100058049	100058049	+	Silent	SNP	G	G	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr3:100058049G>T	uc003dtv.2	+	2	200	c.126G>T	c.(124-126)CCG>CCT	p.P42P	NIT2_uc011bha.1_Silent_p.P42P	NM_020202	NP_064587	Q9NQR4	NIT2_HUMAN	nitrilase family, member 2	42	CN hydrolase.				nitrogen compound metabolic process		omega-amidase activity			ovary(1)	1						TTTCTTTGCCGGTCAGTATGG	0.507			NA											17	99					9.16793e-09	1.18248e-08	0.00499	1	0
CEP97	79598	broad.mit.edu	37	3	101446312	101446312	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr3:101446312G>A	uc003dvk.1	+	3	299	c.272G>A	c.(271-273)AGC>AAC	p.S91N	CEP97_uc010hpm.1_Missense_Mutation_p.S91N|CEP97_uc011bhf.1_Missense_Mutation_p.S91N|CEP97_uc003dvl.1_5'UTR	NM_024548	NP_078824	Q8IW35	CEP97_HUMAN	centrosomal protein 97kDa	91	LRR 3.					centrosome|nucleus	protein binding			ovary(2)	2						CCTCATAATAGCATTGGCTGT	0.398			NA											17	166					0	0	0.006122	0	0
CBLB	868	broad.mit.edu	37	3	105464841	105464841	+	Silent	SNP	C	C	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr3:105464841C>A	uc003dwc.2	-	6	1087	c.765G>T	c.(763-765)GTG>GTT	p.V255V	CBLB_uc011bhi.1_Silent_p.V277V|CBLB_uc003dwd.1_Silent_p.V255V|CBLB_uc003dwe.1_Silent_p.V255V|CBLB_uc011bhj.1_RNA	NM_170662	NP_733762	Q13191	CBLB_HUMAN	Cas-Br-M (murine) ecotropic retroviral	255	Cbl-PTB.|SH2-like.				cell surface receptor linked signaling pathway|NLS-bearing substrate import into nucleus	cytoplasm|nucleus	calcium ion binding|ligase activity|signal transducer activity|zinc ion binding			lung(4)|ovary(3)|breast(1)|skin(1)	9						CTGGATGTGTCACAGCTAAGA	0.333	GBM(93;588 1337 9788 29341 43499)		NA	Mis S		AML								21	164					8.10497e-08	1.01634e-07	0.010504	1	0
MORC1	27136	broad.mit.edu	37	3	108778676	108778676	+	Silent	SNP	T	T	C			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr3:108778676T>C	uc003dxl.2	-	12	1095	c.1008A>G	c.(1006-1008)CAA>CAG	p.Q336Q	MORC1_uc011bhn.1_Silent_p.Q336Q	NM_014429	NP_055244	Q86VD1	MORC1_HUMAN	MORC family CW-type zinc finger 1	336	Potential.				cell differentiation|multicellular organismal development|spermatogenesis	nucleus	ATP binding|zinc ion binding			ovary(3)|skin(3)|breast(2)	8						TAAGATTCTTTTGCTTTGCTT	0.368			NA											20	45					0	0	0.001882	0	0
ZBTB20	26137	broad.mit.edu	37	3	114070473	114070473	+	Missense_Mutation	SNP	A	A	C			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr3:114070473A>C	uc003ebi.2	-	4	632	c.452T>G	c.(451-453)GTG>GGG	p.V151G	ZBTB20_uc003ebj.2_Missense_Mutation_p.V78G|ZBTB20_uc010hqp.2_Missense_Mutation_p.V78G|ZBTB20_uc003ebk.2_Missense_Mutation_p.V78G|ZBTB20_uc003ebl.2_Missense_Mutation_p.V78G|ZBTB20_uc003ebm.2_Missense_Mutation_p.V78G|ZBTB20_uc003ebn.2_Missense_Mutation_p.V78G|uc003ebo.1_5'Flank	NM_015642	NP_056457	Q9HC78	ZBT20_HUMAN	zinc finger and BTB domain containing 20 isoform	151	BTB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(4)|skin(1)	5				LUSC - Lung squamous cell carcinoma(41;0.0581)|Lung(219;0.191)		GAGCTTTTGCACTGACTGCAC	0.592	NSCLC(69;748 1344 9802 11203 30933)		NA											6	49					0	0	0.001168	0	0
GPR156	165829	broad.mit.edu	37	3	119886498	119886498	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr3:119886498C>A	uc011bjf.1	-	9	1826	c.1826G>T	c.(1825-1827)CGC>CTC	p.R609L	GPR156_uc011bjg.1_Missense_Mutation_p.R605L	NM_153002	NP_694547	Q8NFN8	GP156_HUMAN	G protein-coupled receptor 156	609	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity|GABA-B receptor activity			ovary(1)|skin(1)	2				GBM - Glioblastoma multiforme(114;0.19)		AAAGTGTGAGCGGGCCCGCTG	0.602			NA											30	60					1.61788e-16	2.41916e-16	0.002445	1	0
CASR	846	broad.mit.edu	37	3	121980969	121980969	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr3:121980969G>T	uc003eev.3	+	4	1459	c.1087G>T	c.(1087-1089)GGT>TGT	p.G363C	CASR_uc003eew.3_Missense_Mutation_p.G363C	NM_000388	NP_000379	P41180	CASR_HUMAN	calcium-sensing receptor precursor	363	Extracellular (Potential).				anatomical structure morphogenesis|calcium ion import|cellular calcium ion homeostasis|chemosensory behavior|detection of calcium ion|ossification	integral to plasma membrane	G-protein coupled receptor activity|phosphatidylinositol phospholipase C activity			ovary(4)|skin(2)|upper_aerodigestive_tract(1)	7				GBM - Glioblastoma multiforme(114;0.226)	Cinacalcet(DB01012)	CCTCCAAGAAGGTGCAAAAGG	0.502			NA											33	49					2.48696e-23	3.97578e-23	0.003271	1	0
ADCY5	111	broad.mit.edu	37	3	123066664	123066664	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr3:123066664G>C	uc003egh.1	-	3	1371	c.1371C>G	c.(1369-1371)TTC>TTG	p.F457L	ADCY5_uc003egg.1_Missense_Mutation_p.F90L|ADCY5_uc003egi.1_Missense_Mutation_p.F16L	NM_183357	NP_899200	O95622	ADCY5_HUMAN	adenylate cyclase 5	457	Cytoplasmic (Potential).				activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding			ovary(4)	4				GBM - Glioblastoma multiforme(114;0.0342)		AAATCTTATGGAACATCATAT	0.547			NA											36	265					0	0	0.004878	0	0
MYLK	4638	broad.mit.edu	37	3	123456371	123456371	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr3:123456371G>A	uc003ego.2	-	8	890	c.608C>T	c.(607-609)CCG>CTG	p.P203L	MYLK_uc011bjw.1_Missense_Mutation_p.P203L|MYLK_uc003egp.2_Missense_Mutation_p.P203L|MYLK_uc003egq.2_Missense_Mutation_p.P203L|MYLK_uc003egr.2_Missense_Mutation_p.P203L|MYLK_uc003egs.2_Missense_Mutation_p.P27L|MYLK_uc010hrs.1_Missense_Mutation_p.P203L	NM_053025	NP_444253	Q15746	MYLK_HUMAN	myosin light chain kinase isoform 1	203	Ig-like C2-type 2.				aorta smooth muscle tissue morphogenesis|muscle contraction	cytosol	actin binding|ATP binding|calmodulin binding|metal ion binding|myosin light chain kinase activity			ovary(6)|skin(2)|stomach(1)	9		Lung NSC(201;0.0496)		GBM - Glioblastoma multiforme(114;0.0736)		ACGGGCACTCGGCTGCAGTGG	0.542			NA											7	211					0	0	0.001984	0	0
C3orf58	205428	broad.mit.edu	37	3	143704422	143704422	+	Missense_Mutation	SNP	A	A	G			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr3:143704422A>G	uc003evo.2	+	2	1230	c.695A>G	c.(694-696)TAT>TGT	p.Y232C	C3orf58_uc011bnl.1_Missense_Mutation_p.Y23C	NM_173552	NP_775823	Q8NDZ4	CC058_HUMAN	hypothetical protein LOC205428 isoform a	232						COPI vesicle coat|extracellular region				ovary(1)	1						TTTGCAAAGTATCTTGGAGCT	0.393			NA											11	259					0	0	0.000978	0	0
SI	6476	broad.mit.edu	37	3	164767613	164767613	+	Missense_Mutation	SNP	A	A	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr3:164767613A>T	uc003fei.2	-	14	1625	c.1563T>A	c.(1561-1563)AAT>AAA	p.N521K		NM_001041	NP_001032	P14410	SUIS_HUMAN	sucrase-isomaltase	521	Lumenal.|Isomaltase.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			ovary(7)|upper_aerodigestive_tract(4)|skin(2)|pancreas(1)	14		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	ATTTGTTTACATTACATCCTT	0.279			NA								HNSCC(35;0.089)			8	45					0	0	0.006214	0	0
WDR49	151790	broad.mit.edu	37	3	167322097	167322097	+	Missense_Mutation	SNP	T	T	C			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr3:167322097T>C	uc003fev.1	-	2	401	c.95A>G	c.(94-96)AAT>AGT	p.N32S	WDR49_uc011bpd.1_Missense_Mutation_p.N85S|WDR49_uc003few.1_Missense_Mutation_p.N373S	NM_178824	NP_849146	Q8IV35	WDR49_HUMAN	WD repeat domain 49	32	WD 1.									large_intestine(1)|ovary(1)|skin(1)	3						ACCAATTAAATTGAGCCGAGA	0.393			NA											25	73					0	0	0.005443	0	0
GOLIM4	27333	broad.mit.edu	37	3	167728076	167728076	+	Missense_Mutation	SNP	T	T	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr3:167728076T>A	uc003ffe.2	-	16	2416	c.2072A>T	c.(2071-2073)CAT>CTT	p.H691L	GOLIM4_uc011bpe.1_Missense_Mutation_p.H692L|GOLIM4_uc011bpf.1_Missense_Mutation_p.H664L|GOLIM4_uc011bpg.1_Missense_Mutation_p.H663L	NM_014498	NP_055313	O00461	GOLI4_HUMAN	golgi integral membrane protein 4	691	Lumenal (Potential).				transport	cis-Golgi network|endocytic vesicle|endosome membrane|Golgi cisterna membrane|Golgi lumen|integral to membrane|nucleus				breast(4)|skin(1)	5						AGCTCTTCGATGTGATTTCTC	0.428			NA											54	130					0	0	0.00361	0	0
ABCC5	10057	broad.mit.edu	37	3	183682981	183682981	+	Silent	SNP	G	G	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr3:183682981G>A	uc003fmg.2	-	14	2188	c.2023C>T	c.(2023-2025)CTG>TTG	p.L675L	ABCC5_uc011bqt.1_Silent_p.L203L|ABCC5_uc010hxl.2_Silent_p.L675L	NM_005688	NP_005679	O15440	MRP5_HUMAN	ATP-binding cassette, sub-family C, member 5	675	ABC transporter 1.					integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of substances|organic anion transmembrane transporter activity			ovary(2)|large_intestine(1)|central_nervous_system(1)	4	all_cancers(143;1.85e-10)|Ovarian(172;0.0303)		Epithelial(37;1.74e-35)|OV - Ovarian serous cystadenocarcinoma(80;6.48e-22)			ACCTCCGTCAGGTCGCTGCTG	0.597			NA											15	53					0	0	0.006122	0	0
MASP1	5648	broad.mit.edu	37	3	186961390	186961390	+	Silent	SNP	T	T	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr3:186961390T>A	uc003frh.1	-	9	1442	c.1110A>T	c.(1108-1110)CCA>CCT	p.P370P	MASP1_uc003fri.2_Silent_p.P370P|MASP1_uc003frj.2_Silent_p.P339P	NM_001879	NP_001870	P48740	MASP1_HUMAN	mannan-binding lectin serine protease 1 isoform	370	Sushi 2.				complement activation, lectin pathway|negative regulation of complement activation|proteolysis	extracellular space	calcium ion binding|calcium-dependent protein binding|protein binding|protein homodimerization activity|serine-type endopeptidase activity			ovary(2)|breast(1)|liver(1)	4	all_cancers(143;5.33e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;3.49e-18)	GBM - Glioblastoma multiforme(93;0.0366)		CCAGCTCTCCTGGGGCTCTAC	0.458			NA											11	158					0	0	0.000978	0	0
MUC4	4585	broad.mit.edu	37	3	195511959	195511959	+	Silent	SNP	G	G	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr3:195511959G>A	uc011bto.1	-	2	6952	c.6492C>T	c.(6490-6492)ACC>ACT	p.T2164T	MUC4_uc003fvo.2_Intron|MUC4_uc003fvp.2_Intron|MUC4_uc010hzu.1_Intron	NM_018406	NP_060876	Q99102	MUC4_HUMAN	mucin 4 isoform a	45					cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity				0	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		AGGAAGTGTCGGTGACAGGAA	0.577			NA											3	4					0	0	0.009096	0	0
ZNF732	654254	broad.mit.edu	37	4	265785	265785	+	Silent	SNP	A	A	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr4:265785A>T	uc011buu.1	-	3	872	c.858T>A	c.(856-858)ATT>ATA	p.I286I	ZNF732_uc010ibb.1_Intron	NM_001137608	NP_001131080	B4DXR9	ZN732_HUMAN	zinc finger protein 732	287	C2H2-type 6.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						AGGATGAGGTAATGATTTTGC	0.393			NA											3	32					0	0	0.004672	0	0
HGFAC	3083	broad.mit.edu	37	4	3451122	3451122	+	Silent	SNP	C	C	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr4:3451122C>T	uc003ghc.2	+	14	1947	c.1944C>T	c.(1942-1944)CCC>CCT	p.P648P	HGFAC_uc010icw.2_Silent_p.P655P	NM_001528	NP_001519	Q04756	HGFA_HUMAN	HGF activator preproprotein	648					proteolysis	extracellular space	protein binding|serine-type endopeptidase activity			central_nervous_system(2)	2				UCEC - Uterine corpus endometrioid carcinoma (64;0.163)		TACGGCCTCCCAGGCGGCTTG	0.627			NA											5	59					0	0	0.001984	0	0
SLIT2	9353	broad.mit.edu	37	4	20619258	20619258	+	Missense_Mutation	SNP	G	G	C	rs141897818	byFrequency	TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr4:20619258G>C	uc003gpr.1	+	36	4537	c.4333G>C	c.(4333-4335)GAC>CAC	p.D1445H	SLIT2_uc003gps.1_Missense_Mutation_p.D1437H	NM_004787	NP_004778	O94813	SLIT2_HUMAN	slit homolog 2 precursor	1445					apoptosis involved in luteolysis|axon extension involved in axon guidance|branching morphogenesis of a tube|cell migration involved in sprouting angiogenesis|cellular response to heparin|cellular response to hormone stimulus|chemorepulsion involved in postnatal olfactory bulb interneuron migration|corticospinal neuron axon guidance through spinal cord|induction of negative chemotaxis|motor axon guidance|negative regulation of actin filament polymerization|negative regulation of cell growth|negative regulation of cellular response to growth factor stimulus|negative regulation of chemokine-mediated signaling pathway|negative regulation of endothelial cell migration|negative regulation of lamellipodium assembly|negative regulation of mononuclear cell migration|negative regulation of neutrophil chemotaxis|negative regulation of protein phosphorylation|negative regulation of retinal ganglion cell axon guidance|negative regulation of small GTPase mediated signal transduction|negative regulation of smooth muscle cell chemotaxis|negative regulation of vascular permeability|positive regulation of apoptosis|positive regulation of axonogenesis|response to cortisol stimulus|retinal ganglion cell axon guidance|Roundabout signaling pathway|ureteric bud development	cell surface|cytoplasm|extracellular space|plasma membrane	calcium ion binding|GTPase inhibitor activity|heparin binding|laminin-1 binding|protein homodimerization activity|proteoglycan binding|Roundabout binding			central_nervous_system(4)|skin(4)|ovary(3)	11						ATACACGGGGGACAGCTGTGA	0.498			NA											6	28					0	0	0.004482	0	0
PPARGC1A	10891	broad.mit.edu	37	4	23814671	23814671	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr4:23814671G>A	uc003gqs.2	-	9	1991	c.1871C>T	c.(1870-1872)TCA>TTA	p.S624L	PPARGC1A_uc003gqt.2_RNA	NM_013261	NP_037393	Q9UBK2	PRGC1_HUMAN	peroxisome proliferator-activated receptor	624	Arg/Ser-rich.				androgen receptor signaling pathway|brown fat cell differentiation|cellular glucose homeostasis|digestion|fatty acid oxidation|gluconeogenesis|mitochondrion organization|mRNA processing|neuron death|positive regulation of fatty acid oxidation|positive regulation of gluconeogenesis|positive regulation of histone acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|protein complex assembly|protein stabilization|response to muscle activity|response to starvation|RNA splicing|temperature homeostasis|transcription initiation from RNA polymerase II promoter	DNA-directed RNA polymerase II, core complex	androgen receptor binding|DNA binding|ligand-dependent nuclear receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|nucleotide binding|RNA binding|RNA polymerase II transcription cofactor activity|transcription factor binding			ovary(2)|lung(2)|kidney(2)|skin(2)	8		Breast(46;0.0503)				GGGCGATCTTGAACGTGATCT	0.493	Esophageal Squamous(29;694 744 13796 34866 44181)		NA											6	248					0	0	0.001984	0	0
ARAP2	116984	broad.mit.edu	37	4	36212324	36212324	+	Missense_Mutation	SNP	A	A	C			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr4:36212324A>C	uc003gsq.1	-	6	1513	c.1175T>G	c.(1174-1176)GTG>GGG	p.V392G	ARAP2_uc003gsr.1_Missense_Mutation_p.V392G	NM_015230	NP_056045	Q8WZ64	ARAP2_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH	392					regulation of ARF GTPase activity|small GTPase mediated signal transduction	cytosol	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|zinc ion binding			ovary(1)|pancreas(1)|skin(1)	3						AATATCTTCCACCTTGTCCTC	0.343			NA											6	218					0	0	0.001168	0	0
GABRG1	2565	broad.mit.edu	37	4	46067560	46067560	+	Silent	SNP	G	G	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr4:46067560G>A	uc003gxb.2	-	4	515	c.363C>T	c.(361-363)GAC>GAT	p.D121D		NM_173536	NP_775807	Q8N1C3	GBRG1_HUMAN	gamma-aminobutyric acid A receptor, gamma 1	121	Extracellular (Probable).				gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity			ovary(2)	2				Lung(65;0.106)|LUSC - Lung squamous cell carcinoma(721;0.23)		TTAAACGACTGTCAAACCAGG	0.294			NA											13	27					0	0	0.00499	0	0
GABRA2	2555	broad.mit.edu	37	4	46252443	46252443	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr4:46252443C>A	uc003gxc.3	-	9	1911	c.1238G>T	c.(1237-1239)AGT>ATT	p.S413I	GABRA2_uc010igc.2_Missense_Mutation_p.S413I|GABRA2_uc011bzc.1_Missense_Mutation_p.S418I	NM_001114175	NP_001107647	P47869	GBRA2_HUMAN	gamma-aminobutyric acid A receptor, alpha 2	413	Cytoplasmic (Probable).				gamma-aminobutyric acid signaling pathway|neurotransmitter transport|regulation of neurotransmitter levels	cell junction|chloride channel complex|integral to synaptic vesicle membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			ovary(2)|skin(2)	4					Alprazolam(DB00404)|Bromazepam(DB01558)|Diazepam(DB00829)|Ethchlorvynol(DB00189)|Fludiazepam(DB01567)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	TTTGCTAACACTGTTGAAAGT	0.393			NA											27	208					2.48779e-11	3.47851e-11	0.005443	1	0
ATP10D	57205	broad.mit.edu	37	4	47570994	47570994	+	Silent	SNP	T	T	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr4:47570994T>A	uc003gxk.1	+	16	3158	c.2994T>A	c.(2992-2994)ATT>ATA	p.I998I	ATP10D_uc003gxl.1_Silent_p.I246I	NM_020453	NP_065186	Q9P241	AT10D_HUMAN	ATPase, class V, type 10D	998	Cytoplasmic (Potential).|ATP (Potential).				ATP biosynthetic process|cation transport	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(2)|pancreas(1)	3						CTGGACTCATTATCACTGGGA	0.512			NA											26	126					0	0	0.005443	0	0
CORIN	10699	broad.mit.edu	37	4	47663813	47663813	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr4:47663813C>A	uc003gxm.2	-	12	1743	c.1650G>T	c.(1648-1650)CAG>CAT	p.Q550H	CORIN_uc011bzf.1_Missense_Mutation_p.Q411H|CORIN_uc011bzg.1_Missense_Mutation_p.Q483H|CORIN_uc011bzh.1_Missense_Mutation_p.Q513H|CORIN_uc011bzi.1_Missense_Mutation_p.Q513H	NM_006587	NP_006578	Q9Y5Q5	CORIN_HUMAN	corin	550	Extracellular (Potential).|FZ 2.				peptide hormone processing|regulation of systemic arterial blood pressure by atrial natriuretic peptide	integral to membrane|plasma membrane	scavenger receptor activity|serine-type endopeptidase activity|serine-type exopeptidase activity			ovary(1)|central_nervous_system(1)	2						CTTCAGGCCACTGTAGGCCCA	0.398			NA											14	47					3.27435e-08	4.16656e-08	0.00245	1	0
TEC	7006	broad.mit.edu	37	4	48158716	48158716	+	Missense_Mutation	SNP	T	T	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr4:48158716T>A	uc003gxz.2	-	9	864	c.773A>T	c.(772-774)GAG>GTG	p.E258V		NM_003215	NP_003206	P42680	TEC_HUMAN	tec protein tyrosine kinase	258	SH2.				intracellular protein kinase cascade	cytosol	ATP binding|metal ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding			lung(4)|stomach(1)|central_nervous_system(1)|breast(1)|skin(1)|ovary(1)	9						GAGGAGTTGCTCTGCCTTGCT	0.353			NA											11	173					0	0	0.001368	0	0
SCFD2	152579	broad.mit.edu	37	4	54231430	54231430	+	Missense_Mutation	SNP	A	A	C			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr4:54231430A>C	uc003gzu.2	-	1	813	c.679T>G	c.(679-681)TGT>GGT	p.C227G	SCFD2_uc010igm.2_Missense_Mutation_p.C227G	NM_152540	NP_689753	Q8WU76	SCFD2_HUMAN	sec1 family domain containing 2	227					protein transport|vesicle docking involved in exocytosis					ovary(2)|pancreas(1)	3			GBM - Glioblastoma multiforme(3;1.07e-26)|LUSC - Lung squamous cell carcinoma(32;0.0134)			AAATGTTCACACAGAGAACTG	0.527			NA											12	113					0	0	0.001855	0	0
LPHN3	23284	broad.mit.edu	37	4	62775373	62775373	+	Silent	SNP	G	G	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr4:62775373G>T	uc010ihh.2	+	9	1952	c.1779G>T	c.(1777-1779)CGG>CGT	p.R593R	LPHN3_uc003hcq.3_Silent_p.R593R|LPHN3_uc003hct.2_5'UTR|LPHN3_uc003hcs.1_Silent_p.R422R	NM_015236	NP_056051	Q9HAR2	LPHN3_HUMAN	latrophilin 3 precursor	593	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|sugar binding			lung(15)|ovary(1)|central_nervous_system(1)|pancreas(1)	18						ACTCTGTCCGGGCCATGGACC	0.507			NA											8	13					4.68919e-08	5.93505e-08	0.008291	1	0
TECRL	253017	broad.mit.edu	37	4	65146765	65146765	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr4:65146765G>T	uc003hcv.2	-	11	1067	c.958C>A	c.(958-960)CTG>ATG	p.L320M	TECRL_uc010ihi.2_Intron	NM_001010874	NP_001010874	Q5HYJ1	TECRL_HUMAN	steroid 5 alpha-reductase 2-like 2	320	Helical; (Potential).				lipid metabolic process	cytoplasm|integral to membrane	oxidoreductase activity, acting on the CH-CH group of donors				0						TTACCTGGCAGTGTTTGTGTC	0.279			NA											12	23					4.75885e-15	7.02709e-15	0.00499	1	0
UBA6	55236	broad.mit.edu	37	4	68499973	68499973	+	Missense_Mutation	SNP	T	T	G			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr4:68499973T>G	uc003hdg.3	-	22	2052	c.2000A>C	c.(1999-2001)GAA>GCA	p.E667A		NM_018227	NP_060697	A0AVT1	UBA6_HUMAN	ubiquitin-activating enzyme E1-like 2	667					protein ubiquitination|ubiquitin-dependent protein catabolic process	cytoplasm	ATP binding|FAT10 activating enzyme activity|ligase activity|protein binding				0						TAAGACTTCTTCTGCAGATGA	0.279			NA											14	43					0	0	0.003163	0	0
UGT2A3	79799	broad.mit.edu	37	4	69796477	69796477	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr4:69796477G>T	uc003hef.2	-	5	1122	c.1091C>A	c.(1090-1092)CCC>CAC	p.P364H	UGT2A3_uc010ihp.1_RNA	NM_024743	NP_079019	Q6UWM9	UD2A3_HUMAN	UDP glucuronosyltransferase 2 family,	364	Extracellular (Potential).					integral to membrane	glucuronosyltransferase activity			ovary(1)|skin(1)	2						TTTGGTTTTGGGATGACCTAG	0.358			NA											9	44					1.11149e-13	1.61115e-13	0.008291	1	0
UGT2B10	7365	broad.mit.edu	37	4	69874726	69874726	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr4:69874726C>T	uc011cao.1	-	8	1181	c.1045G>A	c.(1045-1047)GGG>AGG	p.G349R	UGT2B10_uc011can.1_Missense_Mutation_p.G265R			P36537	UDB10_HUMAN	RecName: Full=UDP-glucuronosyltransferase 2B28;          Short=UDPGT 2B28;          EC=2.4.1.17; Flags: Precursor;	386					lipid metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			skin(3)|ovary(2)	5						ATAGGGATCCCATGGTAGATT	0.413	Melanoma(133;755 1763 25578 26334 46021)		NA											55	167					0	0	0.00361	0	0
UGT2B10	7365	broad.mit.edu	37	4	69879759	69879759	+	Silent	SNP	A	A	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr4:69879759A>T	uc011cao.1	-	6	1006	c.870T>A	c.(868-870)CTT>CTA	p.L290L	UGT2B10_uc011can.1_Silent_p.L206L			P36537	UDB10_HUMAN	RecName: Full=UDP-glucuronosyltransferase 2B28;          Short=UDPGT 2B28;          EC=2.4.1.17; Flags: Precursor;	327					lipid metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			skin(3)|ovary(2)	5						GGATCTTGGCAAGGGCTGTTG	0.413	Melanoma(133;755 1763 25578 26334 46021)		NA											14	167					0	0	0.004007	0	0
UGT2B28	54490	broad.mit.edu	37	4	70160485	70160485	+	Silent	SNP	C	C	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr4:70160485C>T	uc003hej.2	+	6	1550	c.1548C>T	c.(1546-1548)TTC>TTT	p.F516F	UGT2B28_uc010ihr.2_3'UTR	NM_053039	NP_444267	Q9BY64	UDB28_HUMAN	UDP glucuronosyltransferase 2 family,	516	Helical; (Potential).				xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			skin(1)	1					Flunitrazepam(DB01544)	TGTTTTGTTTCTGGAAGTTTG	0.413			NA											6	102					0	0	0.00308	0	0
UGT2A1	10941	broad.mit.edu	37	4	70460881	70460881	+	Silent	SNP	A	A	G			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr4:70460881A>G	uc003hem.3	-	4	1146	c.1083T>C	c.(1081-1083)CTT>CTC	p.L361L	UGT2A1_uc011caq.1_Silent_p.L527L|UGT2A1_uc010ihu.2_Silent_p.L361L|UGT2A1_uc010iht.2_Silent_p.L317L|UGT2A1_uc010ihs.2_Silent_p.L362L	NM_006798	NP_006789	Q9Y4X1	UD2A1_HUMAN	UDP glucuronosyltransferase 2 family,	361	Extracellular (Potential).				detection of chemical stimulus|sensory perception of smell	integral to membrane	glucuronosyltransferase activity|glucuronosyltransferase activity			ovary(1)	1						CAGTCTTACCAAGAAGATCAT	0.338			NA											25	95					0	0	0.005443	0	0
ANKRD17	26057	broad.mit.edu	37	4	74008402	74008402	+	Silent	SNP	C	C	G			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr4:74008402C>G	uc003hgp.2	-	12	2157	c.2040G>C	c.(2038-2040)GTG>GTC	p.V680V	ANKRD17_uc003hgo.2_Silent_p.V567V|ANKRD17_uc003hgq.2_Silent_p.V680V|ANKRD17_uc003hgr.2_Silent_p.V680V|ANKRD17_uc011cbd.1_Silent_p.V245V	NM_032217	NP_115593	O75179	ANR17_HUMAN	ankyrin repeat domain protein 17 isoform a	680	ANK 14.				interspecies interaction between organisms	cytoplasm|nucleus	RNA binding			ovary(5)|skin(3)|upper_aerodigestive_tract(1)|lung(1)	10	Breast(15;0.000295)		Epithelial(6;8.86e-07)|OV - Ovarian serous cystadenocarcinoma(6;6.22e-06)|all cancers(17;1.51e-05)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			AAAGTAGTTCCACCACTGCCA	0.433			NA											7	136					0	0	0.00308	0	0
CXCL1	2919	broad.mit.edu	37	4	74735400	74735400	+	Missense_Mutation	SNP	A	A	G			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr4:74735400A>G	uc003hhh.1	+	2	194	c.115A>G	c.(115-117)ACT>GCT	p.T39A		NM_001511	NP_001502	P09341	GROA_HUMAN	chemokine (C-X-C motif) ligand 1	39					actin cytoskeleton organization|cell proliferation|chemotaxis|G-protein coupled receptor protein signaling pathway|immune response|inflammatory response|intracellular signal transduction|negative regulation of cell proliferation|nervous system development	extracellular space|intracellular	chemokine activity|enzyme activator activity|growth factor activity				0	Breast(15;0.00102)		all cancers(17;0.00176)|Lung(101;0.128)|LUSC - Lung squamous cell carcinoma(112;0.187)			GTCCGTGGCCACTGAACTGCG	0.652			NA											18	142					0	0	0.010504	0	0
BMP3	651	broad.mit.edu	37	4	81967195	81967195	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr4:81967195G>T	uc003hmg.3	+	2	940	c.620G>T	c.(619-621)AGG>ATG	p.R207M		NM_001201	NP_001192	P12645	BMP3_HUMAN	bone morphogenetic protein 3 preproprotein	207					cartilage development|cell differentiation|cell-cell signaling|growth|ossification	extracellular space	BMP receptor binding|cytokine activity|growth factor activity			ovary(4)|central_nervous_system(1)	5						CAACTCTTGAGGAAGGCCAAA	0.438			NA											35	304					9.17885e-22	1.44785e-21	0.003271	1	0
FAM175A	84142	broad.mit.edu	37	4	84391519	84391519	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr4:84391519G>C	uc003hou.2	-	5	378	c.313C>G	c.(313-315)CAT>GAT	p.H105D	FAM175A_uc003hot.2_5'Flank|FAM175A_uc003hov.2_5'UTR	NM_139076	NP_620775	Q6UWZ7	F175A_HUMAN	coiled-coil domain containing 98	105	MPN-like.				chromatin modification|double-strand break repair|G2/M transition DNA damage checkpoint|positive regulation of DNA repair|response to ionizing radiation	BRCA1-A complex	polyubiquitin binding			kidney(1)	1						TGATCTGAATGACGACGGAAT	0.333			NA											5	155					0	0	0.001168	0	0
GRID2	2895	broad.mit.edu	37	4	94343933	94343933	+	Silent	SNP	T	T	C			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr4:94343933T>C	uc011cdt.1	+	10	1617	c.1359T>C	c.(1357-1359)TTT>TTC	p.F453F	GRID2_uc011cdu.1_Silent_p.F358F	NM_001510	NP_001501	O43424	GRID2_HUMAN	glutamate receptor, ionotropic, delta 2	453	Extracellular (Potential).				glutamate signaling pathway	cell junction|integral to plasma membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			ovary(3)|skin(2)|large_intestine(1)	6		Hepatocellular(203;0.114)|all_hematologic(202;0.177)		OV - Ovarian serous cystadenocarcinoma(123;3.22e-06)|LUSC - Lung squamous cell carcinoma(81;0.185)|Lung(65;0.191)	L-Glutamic Acid(DB00142)	AAGAACCTTTTGTGATGGTCT	0.358			NA											22	42					0	0	0.00278	0	0
PDHA2	5161	broad.mit.edu	37	4	96762021	96762021	+	Nonsense_Mutation	SNP	C	C	G			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr4:96762021C>G	uc003htr.3	+	1	783	c.720C>G	c.(718-720)TAC>TAG	p.Y240*		NM_005390	NP_005381	P29803	ODPAT_HUMAN	pyruvate dehydrogenase E1 alpha 2 precursor	240					glycolysis	mitochondrial matrix	pyruvate dehydrogenase (acetyl-transferring) activity			central_nervous_system(1)	1		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;1.23e-06)	NADH(DB00157)	GCCCTGATTACTACAAGAGGG	0.428			NA											8	57					0	0	0.006214	0	0
ADH1B	125	broad.mit.edu	37	4	100237263	100237263	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr4:100237263G>T	uc003hus.3	-	5	443	c.359C>A	c.(358-360)CCT>CAT	p.P120H	ADH1A_uc011ceg.1_Intron|ADH1B_uc003hut.3_Missense_Mutation_p.P80H|ADH1B_uc011ceh.1_Intron|ADH1B_uc011cei.1_Missense_Mutation_p.P80H	NM_000668	NP_000659	P00325	ADH1B_HUMAN	class I alcohol dehydrogenase, beta subunit	120					ethanol oxidation|xenobiotic metabolic process	cytosol	alcohol dehydrogenase activity, zinc-dependent|zinc ion binding			ovary(1)|breast(1)	2				OV - Ovarian serous cystadenocarcinoma(123;1.02e-07)	Fomepizole(DB01213)|NADH(DB00157)	GGTCCCCCGAGGATTGCCTAG	0.547			NA											27	37					7.41945e-09	9.6088e-09	0.005443	1	0
NPNT	255743	broad.mit.edu	37	4	106861316	106861316	+	Missense_Mutation	SNP	G	G	C	rs144069851	byFrequency	TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr4:106861316G>C	uc003hya.2	+	6	795	c.590G>C	c.(589-591)TGT>TCT	p.C197S	NPNT_uc011cfc.1_Missense_Mutation_p.C214S|NPNT_uc011cfd.1_Missense_Mutation_p.C227S|NPNT_uc011cfe.1_Missense_Mutation_p.C227S|NPNT_uc010ilt.1_Missense_Mutation_p.C197S|NPNT_uc011cff.1_Missense_Mutation_p.C197S|NPNT_uc010ilu.1_Missense_Mutation_p.C93S	NM_001033047	NP_001028219	Q6UXI9	NPNT_HUMAN	nephronectin precursor	197	EGF-like 4; calcium-binding (Potential).				cell differentiation	membrane	calcium ion binding			skin(1)	1		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;5.41e-07)		ATCTGCAAGTGTCATAAAGGC	0.408			NA											25	130					0	0	0.004656	0	0
PAPSS1	9061	broad.mit.edu	37	4	108552980	108552980	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr4:108552980C>A	uc003hyk.2	-	11	1627	c.1543G>T	c.(1543-1545)GCC>TCC	p.A515S		NM_005443	NP_005434	O43252	PAPS1_HUMAN	3'-phosphoadenosine 5'-phosphosulfate synthase	515	Adenylyl-sulfate kinase.				3'-phosphoadenosine 5'-phosphosulfate biosynthetic process|skeletal system development|sulfate assimilation|xenobiotic metabolic process	cytosol	adenylylsulfate kinase activity|ATP binding|sulfate adenylyltransferase (ATP) activity			ovary(1)	1		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;5.49e-05)		TAAAAGTTGGCTCCTGCAACC	0.433			NA											6	40					0.00198382	0.00213469	0.001984	1	0
AGXT2L1	64850	broad.mit.edu	37	4	109672168	109672168	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr4:109672168C>A	uc003hzc.2	-	7	806	c.625G>T	c.(625-627)GCC>TCC	p.A209S	AGXT2L1_uc010imc.2_Missense_Mutation_p.A203S|AGXT2L1_uc011cfm.1_Missense_Mutation_p.A169S|AGXT2L1_uc011cfn.1_Missense_Mutation_p.A136S|AGXT2L1_uc011cfo.1_Missense_Mutation_p.A151S	NM_031279	NP_112569	Q8TBG4	AT2L1_HUMAN	alanine-glyoxylate aminotransferase 2-like 1	209					cellular amino acid metabolic process	mitochondrion	alanine-glyoxylate transaminase activity|pyridoxal phosphate binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(123;0.000281)		GCAATAAAGGCAGCAATCTAT	0.433			NA											59	94					6.12789e-21	9.5862e-21	0.00361	1	0
NDST4	64579	broad.mit.edu	37	4	115760594	115760594	+	Silent	SNP	T	T	C			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr4:115760594T>C	uc003ibu.2	-	11	2905	c.2226A>G	c.(2224-2226)CTA>CTG	p.L742L	NDST4_uc010imw.2_RNA	NM_022569	NP_072091	Q9H3R1	NDST4_HUMAN	heparan sulfate N-deacetylase/N-sulfotransferase	742	Lumenal (Potential).|Heparan sulfate N-sulfotransferase 4.					Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine N-sulfotransferase activity|hydrolase activity			skin(3)|ovary(1)	4		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.000562)		ATCCAGGTACTAGGCATCTTC	0.378			NA											8	120					0	0	0.008291	0	0
KIAA1109	84162	broad.mit.edu	37	4	123155942	123155942	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr4:123155942G>T	uc003ieh.2	+	25	3383	c.3338G>T	c.(3337-3339)TGG>TTG	p.W1113L	KIAA1109_uc003iei.1_Missense_Mutation_p.W866L|KIAA1109_uc010ins.1_Missense_Mutation_p.W456L	NM_015312	NP_056127	Q2LD37	K1109_HUMAN	fragile site-associated protein	1113					regulation of cell growth|regulation of epithelial cell differentiation	integral to membrane|nucleus				ovary(8)|skin(2)|pancreas(1)|central_nervous_system(1)	12						TGGTTTTTATGGCCAGATGAT	0.343			NA											19	107					1.64113e-05	1.9113e-05	0.010504	1	0
FAT4	79633	broad.mit.edu	37	4	126412916	126412916	+	Missense_Mutation	SNP	A	A	G			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr4:126412916A>G	uc003ifj.3	+	17	14939	c.14939A>G	c.(14938-14940)TAT>TGT	p.Y4980C	FAT4_uc011cgp.1_Missense_Mutation_p.Y3221C|FAT4_uc003ifi.1_Missense_Mutation_p.Y2457C	NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	4980	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18						GCAGAACAGTATGTGTGAAGT	0.373			NA											3	21					0	0	0.009096	0	0
PCDH10	57575	broad.mit.edu	37	4	134072018	134072018	+	Silent	SNP	G	G	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr4:134072018G>T	uc003iha.2	+	1	1549	c.723G>T	c.(721-723)CTG>CTT	p.L241L	uc003igy.2_5'Flank|PCDH10_uc003igz.2_Silent_p.L241L	NM_032961	NP_116586	Q9P2E7	PCD10_HUMAN	protocadherin 10 isoform 1 precursor	241	Extracellular (Potential).|Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)	2				LUSC - Lung squamous cell carcinoma(193;0.227)		TCCGAGTGCTGGACTCCAATG	0.483			NA											10	77					5.50884e-06	6.51169e-06	0.001368	1	0
PCDH10	57575	broad.mit.edu	37	4	134072783	134072783	+	Silent	SNP	C	C	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr4:134072783C>A	uc003iha.2	+	1	2314	c.1488C>A	c.(1486-1488)GCC>GCA	p.A496A	uc003igy.2_5'Flank|PCDH10_uc003igz.2_Silent_p.A496A	NM_032961	NP_116586	Q9P2E7	PCD10_HUMAN	protocadherin 10 isoform 1 precursor	496	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)	2				LUSC - Lung squamous cell carcinoma(193;0.227)		GCGCCAACGCCCAGCTTGCCT	0.587			NA											11	61					5.16669e-11	7.16085e-11	0.000978	1	0
PCDH10	57575	broad.mit.edu	37	4	134073068	134073068	+	Silent	SNP	C	C	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr4:134073068C>A	uc003iha.2	+	1	2599	c.1773C>A	c.(1771-1773)CCC>CCA	p.P591P	uc003igy.2_5'Flank|PCDH10_uc003igz.2_Silent_p.P591P	NM_032961	NP_116586	Q9P2E7	PCD10_HUMAN	protocadherin 10 isoform 1 precursor	591	Cadherin 6.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)	2				LUSC - Lung squamous cell carcinoma(193;0.227)		AGGTGCTGCCCCGCTCGGCGG	0.667			NA											20	23					3.62473e-10	4.91595e-10	0.001882	1	0
ELF2	1998	broad.mit.edu	37	4	139981626	139981626	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr4:139981626C>A	uc003ihp.1	-	8	1179	c.973G>T	c.(973-975)GTT>TTT	p.V325F	ELF2_uc003ihm.1_Missense_Mutation_p.V277F|ELF2_uc003ihn.1_Missense_Mutation_p.V265F|ELF2_uc003iho.1_Missense_Mutation_p.V248F|ELF2_uc011chc.1_Missense_Mutation_p.V140F	NM_201999	NP_973728	Q15723	ELF2_HUMAN	E74-like factor 2 (ets domain transcription	337					negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter	cytoplasm	protein binding|sequence-specific DNA binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|sequence-specific DNA binding transcription factor activity			ovary(1)|skin(1)	2	all_hematologic(180;0.162)					CCACTGCGAACAGAGGATGCT	0.438			NA											22	129					6.44725e-10	8.6695e-10	0.002299	1	0
NR3C2	4306	broad.mit.edu	37	4	149357469	149357469	+	Nonsense_Mutation	SNP	T	T	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr4:149357469T>A	uc003ilj.3	-	2	878	c.544A>T	c.(544-546)AAA>TAA	p.K182*	NR3C2_uc003ilk.3_Nonsense_Mutation_p.K182*|NR3C2_uc010iph.2_RNA	NM_000901	NP_000892	P08235	MCR_HUMAN	nuclear receptor subfamily 3, group C, member 2	182	Modulating.				regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	endoplasmic reticulum membrane|nucleoplasm	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|zinc ion binding			large_intestine(1)	1	all_hematologic(180;0.151)			GBM - Glioblastoma multiforme(119;0.0614)	Desoxycorticosterone Pivalate(DB01134)|Eplerenone(DB00700)|Fludrocortisone(DB00687)|Spironolactone(DB00421)	ATAGGGCTTTTAACAACGGCG	0.512	Melanoma(27;428 957 40335 51025 51111)		NA											5	114					0	0	0.000602	0	0
MAB21L2	10586	broad.mit.edu	37	4	151504393	151504393	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr4:151504393C>A	uc003ilw.2	+	1	1317	c.212C>A	c.(211-213)CCC>CAC	p.P71H	LRBA_uc003ils.3_5'Flank|LRBA_uc003ilt.3_Intron|LRBA_uc003ilu.3_Intron|LRBA_uc010ipj.2_Intron	NM_006439	NP_006430	Q9Y586	MB212_HUMAN	mab-21-like protein 2	71					nervous system development	nucleus				ovary(1)	1	all_hematologic(180;0.151)			GBM - Glioblastoma multiforme(119;0.159)		GTCATTTCGCCCACCGAATTT	0.597			NA											23	34					2.44723e-14	3.56919e-14	0.004656	1	0
NPY2R	4887	broad.mit.edu	37	4	156135336	156135336	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr4:156135336G>C	uc003ioq.2	+	2	740	c.245G>C	c.(244-246)CGC>CCC	p.R82P	NPY2R_uc003ior.2_Missense_Mutation_p.R82P	NM_000910	NP_000901	P49146	NPY2R_HUMAN	neuropeptide Y receptor Y2	82	Cytoplasmic (Potential).				cardiac left ventricle morphogenesis|inhibition of adenylate cyclase activity by G-protein signaling pathway|locomotory behavior|outflow tract morphogenesis	integral to plasma membrane	calcium channel regulator activity			lung(2)|skin(1)	3	all_hematologic(180;0.24)	Renal(120;0.0854)				AAGAGCATGCGCACAGTAACC	0.453			NA											6	53					0	0	0.001168	0	0
MORF4	10934	broad.mit.edu	37	4	174537438	174537438	+	Silent	SNP	T	T	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr4:174537438T>A	uc011cke.1	-	1	357	c.357A>T	c.(355-357)ACA>ACT	p.T119T		NM_006792	NP_006783			mortality factor 4												0		Prostate(90;0.00201)|Renal(120;0.0183)|Melanoma(52;0.0749)|all_neural(102;0.0765)|all_hematologic(60;0.107)		all cancers(43;1.88e-18)|Epithelial(43;1.19e-16)|OV - Ovarian serous cystadenocarcinoma(60;1.38e-09)|STAD - Stomach adenocarcinoma(60;0.00273)|GBM - Glioblastoma multiforme(59;0.0064)|LUSC - Lung squamous cell carcinoma(193;0.0903)|Kidney(143;0.249)		CCTTATTATCTGTGTTTCCAT	0.393			NA											15	247					0	0	0.003163	0	0
SPCS3	60559	broad.mit.edu	37	4	177241368	177241368	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr4:177241368G>C	uc003iur.3	+	1	279	c.141G>C	c.(139-141)ATG>ATC	p.M47I		NM_021928	NP_068747	P61009	SPCS3_HUMAN	signal peptidase complex subunit 3	47	Lumenal (Potential).				energy reserve metabolic process|regulation of insulin secretion|signal peptide processing	integral to membrane|microsome|signal peptidase complex	peptidase activity			ovary(1)	1		Breast(14;0.0011)|Prostate(90;0.0129)|Melanoma(52;0.0133)|Renal(120;0.0376)|all_hematologic(60;0.124)		all cancers(43;2.43e-19)|Epithelial(43;1.84e-16)|OV - Ovarian serous cystadenocarcinoma(60;4.51e-09)|GBM - Glioblastoma multiforme(59;0.000142)|STAD - Stomach adenocarcinoma(60;0.00279)|LUSC - Lung squamous cell carcinoma(193;0.0319)		CGCGGATCATGCTGTGAGTGA	0.348			NA											13	28					0	0	0.001855	0	0
ANKRD37	353322	broad.mit.edu	37	4	186320857	186320857	+	Missense_Mutation	SNP	T	T	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr4:186320857T>A	uc003ixm.2	+	4	644	c.406T>A	c.(406-408)TGT>AGT	p.C136S	ANKRD37_uc011cks.1_Missense_Mutation_p.C136S|UFSP2_uc003ixn.2_3'UTR|UFSP2_uc003ixo.2_3'UTR|UFSP2_uc003ixq.2_3'UTR|UFSP2_uc003ixp.2_RNA	NM_181726	NP_859077	Q7Z713	ANR37_HUMAN	ankyrin repeat domain 37	136						cytoplasm|nucleus					0		all_lung(41;1.3e-11)|Lung NSC(41;2.25e-11)|Melanoma(20;0.00109)|Colorectal(36;0.0215)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|all_hematologic(60;0.0749)		all cancers(43;1.27e-25)|Epithelial(43;1.02e-22)|OV - Ovarian serous cystadenocarcinoma(60;1.14e-11)|BRCA - Breast invasive adenocarcinoma(30;7.72e-05)|GBM - Glioblastoma multiforme(59;0.000118)|STAD - Stomach adenocarcinoma(60;0.000756)|LUSC - Lung squamous cell carcinoma(40;0.00902)|COAD - Colon adenocarcinoma(29;0.00939)|READ - Rectum adenocarcinoma(43;0.155)		CAGGAATGATTGTGTTGCCGT	0.438			NA											14	105					0	0	0.00499	0	0
ZFP42	132625	broad.mit.edu	37	4	188924650	188924650	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr4:188924650C>T	uc003izg.1	+	3	934	c.689C>T	c.(688-690)TCA>TTA	p.S230L	ZFP42_uc003izh.1_Missense_Mutation_p.S230L|ZFP42_uc003izi.1_Missense_Mutation_p.S230L	NM_174900	NP_777560	Q96MM3	ZFP42_HUMAN	zinc finger protein 42	230	C2H2-type 2.				female gonad development|male gonad development|meiosis	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|skin(1)	2		all_cancers(14;6.2e-52)|all_epithelial(14;7.36e-37)|all_lung(41;2.29e-15)|Lung NSC(41;6.7e-15)|Breast(6;1.53e-05)|Melanoma(20;3.01e-05)|Hepatocellular(41;0.00335)|all_hematologic(60;0.014)|Renal(120;0.0183)|Prostate(90;0.0421)|Colorectal(36;0.227)		OV - Ovarian serous cystadenocarcinoma(60;1.54e-11)|BRCA - Breast invasive adenocarcinoma(30;4.21e-06)|GBM - Glioblastoma multiforme(59;8.93e-05)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.157)		GTTGAGAGCTCAAAACTAAAG	0.493			NA											6	78					0	0	0.001984	0	0
SLC9A3	6550	broad.mit.edu	37	5	482784	482784	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr5:482784C>T	uc003jbe.2	-	7	1347	c.1235G>A	c.(1234-1236)GGG>GAG	p.G412E	SLC9A3_uc011clx.1_Missense_Mutation_p.G412E	NM_004174	NP_004165	P48764	SL9A3_HUMAN	solute carrier family 9 (sodium/hydrogen	412						cell surface|integral to membrane	sodium:hydrogen antiporter activity				0			Epithelial(17;0.000529)|OV - Ovarian serous cystadenocarcinoma(19;0.00153)|all cancers(22;0.00186)|Lung(60;0.0863)			GCGCAGGCCCCCGTAGGACAG	0.627			NA											7	24					0	0	0.00308	0	0
ZDHHC11	79844	broad.mit.edu	37	5	850557	850557	+	Missense_Mutation	SNP	G	G	A	rs145802626		TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr5:850557G>A	uc011cma.1	-	1	545	c.161C>T	c.(160-162)TCG>TTG	p.S54L	ZDHHC11_uc003jbj.2_5'Flank	NM_024786	NP_079062	Q9H8X9	ZDH11_HUMAN	zinc finger, DHHC-type containing 11	54	Helical; (Potential).					integral to membrane	acyltransferase activity|zinc ion binding			skin(1)|pancreas(1)	2			Epithelial(17;0.000445)|all cancers(22;0.00176)|OV - Ovarian serous cystadenocarcinoma(19;0.00227)|Lung(60;0.0863)			GAAGGTGGCCGAGGAAAGGCC	0.582			NA											9	48					0	0	0.004482	0	0
BRD9	65980	broad.mit.edu	37	5	870664	870664	+	Silent	SNP	G	G	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr5:870664G>A	uc003jbq.2	-	14	1616	c.1449C>T	c.(1447-1449)AGC>AGT	p.S483S	BRD9_uc003jbl.2_Silent_p.S367S|BRD9_uc003jbm.2_RNA|BRD9_uc003jbn.2_RNA|BRD9_uc011cmb.1_Silent_p.S430S|BRD9_uc003jbo.2_Silent_p.S387S|BRD9_uc003jbp.2_Silent_p.S144S	NM_023924	NP_076413	Q9H8M2	BRD9_HUMAN	bromodomain containing 9 isoform 1	483							nucleic acid binding				0			Epithelial(17;0.00202)|OV - Ovarian serous cystadenocarcinoma(19;0.00353)|all cancers(22;0.00815)|Lung(60;0.185)			GAACAGAGCTGCTGCTGTCTC	0.478			NA											15	38					0	0	0.003163	0	0
ADAMTS16	170690	broad.mit.edu	37	5	5190192	5190192	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr5:5190192C>A	uc003jdl.2	+	7	1294	c.1156C>A	c.(1156-1158)CTG>ATG	p.L386M	ADAMTS16_uc003jdk.1_Missense_Mutation_p.L386M|ADAMTS16_uc003jdj.1_Missense_Mutation_p.L386M	NM_139056	NP_620687	Q8TE57	ATS16_HUMAN	ADAM metallopeptidase with thrombospondin type 1	386	Peptidase M12B.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(3)|lung(2)|large_intestine(1)|breast(1)|pancreas(1)	8						CGCCATCTTACTGACTGGTCT	0.527			NA											17	88					0.00498961	0.00529692	0.00499	1	0
SEMA5A	9037	broad.mit.edu	37	5	9122842	9122842	+	Silent	SNP	G	G	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr5:9122842G>A	uc003jek.2	-	14	2419	c.1707C>T	c.(1705-1707)TCC>TCT	p.S569S		NM_003966	NP_003957	Q13591	SEM5A_HUMAN	semaphorin 5A precursor	569	Extracellular (Potential).|TSP type-1 1.				cell adhesion|cell-cell signaling	integral to membrane|plasma membrane				ovary(1)|central_nervous_system(1)	2						GGCTGTCGCAGGAGCGGGTTC	0.652			NA											12	75					0	0	0.005443	0	0
DNAH5	1767	broad.mit.edu	37	5	13824339	13824339	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr5:13824339C>A	uc003jfd.2	-	39	6590	c.6548G>T	c.(6547-6549)CGT>CTT	p.R2183L		NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	2183					microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					CCGTAGTACACGCATGACAAT	0.448			NA							Kartagener_syndrome				21	67					5.26018e-13	7.55553e-13	0.001882	1	0
FBXL7	23194	broad.mit.edu	37	5	15928063	15928063	+	Silent	SNP	C	C	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr5:15928063C>A	uc003jfn.1	+	3	673	c.192C>A	c.(190-192)CTC>CTA	p.L64L		NM_012304	NP_036436	Q9UJT9	FBXL7_HUMAN	F-box and leucine-rich repeat protein 7	64					ubiquitin-dependent protein catabolic process	ubiquitin ligase complex	protein binding|ubiquitin-protein ligase activity			ovary(2)|lung(1)	3						CACCGAATCTCCCAGGATTTC	0.607			NA											7	100					4.68919e-08	5.93505e-08	0.008291	1	0
NIPBL	25836	broad.mit.edu	37	5	36985213	36985213	+	Missense_Mutation	SNP	T	T	C			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr5:36985213T>C	uc003jkl.3	+	10	2430	c.1931T>C	c.(1930-1932)GTT>GCT	p.V644A	NIPBL_uc003jkk.3_Missense_Mutation_p.V644A|NIPBL_uc003jkm.1_Missense_Mutation_p.V523A	NM_133433	NP_597677	Q6KC79	NIPBL_HUMAN	delangin isoform A	644					brain development|cellular protein localization|cellular response to X-ray|cognition|developmental growth|ear morphogenesis|embryonic arm morphogenesis|embryonic digestive tract morphogenesis|external genitalia morphogenesis|eye morphogenesis|face morphogenesis|gall bladder development|maintenance of mitotic sister chromatid cohesion|metanephros development|negative regulation of transcription from RNA polymerase II promoter|outflow tract morphogenesis|positive regulation of histone deacetylation|regulation of developmental growth|regulation of embryonic development|regulation of hair cycle|response to DNA damage stimulus|sensory perception of sound|uterus morphogenesis	SMC loading complex	chromo shadow domain binding|histone deacetylase binding|protein C-terminus binding|protein N-terminus binding			ovary(4)|lung(2)|large_intestine(1)|breast(1)|kidney(1)	9	all_lung(31;0.000447)|Hepatocellular(1;0.108)		Epithelial(62;0.072)|COAD - Colon adenocarcinoma(61;0.14)|all cancers(62;0.191)|Colorectal(62;0.202)			GAAACTAAAGTTGAGACCCAA	0.338			NA											17	89					0	0	0.004007	0	0
EGFLAM	133584	broad.mit.edu	37	5	38370435	38370435	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr5:38370435C>T	uc003jlc.1	+	6	907	c.583C>T	c.(583-585)CGG>TGG	p.R195W	EGFLAM_uc003jlb.1_Missense_Mutation_p.R195W	NM_152403	NP_689616	Q63HQ2	EGFLA_HUMAN	EGF-like, fibronectin type III and laminin G	195	Fibronectin type-III 2.					cell junction|proteinaceous extracellular matrix|synapse				pancreas(3)|skin(3)|ovary(1)	7	all_lung(31;0.000385)					AATCCATGAGCGGATCCAGAT	0.498	Colon(62;485 1295 3347 17454)		NA											10	71					0	0	0.008291	0	0
EGFLAM	133584	broad.mit.edu	37	5	38445800	38445800	+	Silent	SNP	C	C	G			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr5:38445800C>G	uc003jlc.1	+	18	2808	c.2484C>G	c.(2482-2484)CTC>CTG	p.L828L	EGFLAM_uc003jlb.1_Intron|EGFLAM_uc003jle.1_Intron|EGFLAM_uc003jlf.1_Intron|EGFLAM_uc003jlg.1_5'UTR	NM_152403	NP_689616	Q63HQ2	EGFLA_HUMAN	EGF-like, fibronectin type III and laminin G	828						cell junction|proteinaceous extracellular matrix|synapse				pancreas(3)|skin(3)|ovary(1)	7	all_lung(31;0.000385)					ACTACTGCCTCAATAGTAAGT	0.567	Colon(62;485 1295 3347 17454)		NA											28	158					0	0	0.007291	0	0
FAM81B	153643	broad.mit.edu	37	5	94727200	94727200	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr5:94727200C>A	uc003kla.1	+	1	153	c.107C>A	c.(106-108)GCA>GAA	p.A36E	FAM81B_uc010jbe.1_5'Flank	NM_152548	NP_689761	Q96LP2	FA81B_HUMAN	hypothetical protein LOC153643	36										ovary(1)|skin(1)	2		all_cancers(142;1.1e-06)|all_epithelial(76;1.48e-09)|all_lung(232;0.000696)|Lung NSC(167;0.000947)|Ovarian(225;0.00473)		all cancers(79;1.04e-16)		GCTGGAAAAGCAAGCATCATG	0.299			NA											13	95					2.32078e-09	3.06421e-09	0.003163	1	0
PDLIM4	8572	broad.mit.edu	37	5	131606626	131606626	+	Missense_Mutation	SNP	A	A	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr5:131606626A>T	uc003kwn.2	+	4	423	c.346A>T	c.(346-348)AGC>TGC	p.S116C	uc003kwm.3_Intron|PDLIM4_uc003kwp.2_Missense_Mutation_p.S116C|PDLIM4_uc003kwo.2_Missense_Mutation_p.S116C	NM_003687	NP_003678	P50479	PDLI4_HUMAN	PDZ and LIM domain 4 isoform 1	116							protein binding|zinc ion binding			ovary(1)|central_nervous_system(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			CCCAACAACCAGCAGGCGGCC	0.622			NA											25	100					0	0	0.002096	0	0
PSD2	84249	broad.mit.edu	37	5	139216500	139216500	+	Missense_Mutation	SNP	T	T	C			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr5:139216500T>C	uc003leu.1	+	10	1713	c.1508T>C	c.(1507-1509)CTG>CCG	p.L503P		NM_032289	NP_115665	Q9BQI7	PSD2_HUMAN	pleckstrin and Sec7 domain containing 2	503					regulation of ARF protein signal transduction	cytoplasm|integral to membrane	ARF guanyl-nucleotide exchange factor activity			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AACCCCTTCCTGGATGTCCCA	0.592			NA											39	138					0	0	0.002522	0	0
PCDHA3	56145	broad.mit.edu	37	5	140181570	140181570	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr5:140181570C>T	uc003lhf.2	+	1	788	c.788C>T	c.(787-789)ACC>ATC	p.T263I	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA2_uc011czy.1_Intron|PCDHA3_uc011czz.1_Missense_Mutation_p.T263I	NM_018906	NP_061729	Q9Y5H8	PCDA3_HUMAN	protocadherin alpha 3 isoform 1 precursor	263	Cadherin 3.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(6)|skin(2)	8			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTAGTGGTGACCGTTAACGCC	0.408			NA											25	83					0	0	0.00333	0	0
PCDHA6	56142	broad.mit.edu	37	5	140207847	140207847	+	Silent	SNP	G	G	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr5:140207847G>T	uc003lho.2	+	1	198	c.171G>T	c.(169-171)GCG>GCT	p.A57A	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Silent_p.A57A|PCDHA6_uc011dab.1_Silent_p.A57A	NM_018909	NP_061732	Q9UN73	PCDA6_HUMAN	protocadherin alpha 6 isoform 1 precursor	57	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	extracellular region|integral to plasma membrane	calcium ion binding|protein binding			haematopoietic_and_lymphoid_tissue(1)|skin(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGGAGCTGGCGGAGCTGGTGC	0.622			NA											10	105					2.27111e-07	2.78527e-07	0.001368	1	0
PCDHA7	56141	broad.mit.edu	37	5	140215062	140215062	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr5:140215062C>A	uc003lhq.2	+	1	1094	c.1094C>A	c.(1093-1095)CCA>CAA	p.P365Q	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc011dac.1_Missense_Mutation_p.P365Q	NM_018910	NP_061733	Q9UN72	PCDA7_HUMAN	protocadherin alpha 7 isoform 1 precursor	365	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(2)|skin(2)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GACGCCCAACCAGGTACCGTC	0.507	NSCLC(160;258 2013 5070 22440 28951)		NA											27	144					2.12542e-12	3.02083e-12	0.00632	1	0
PCDHB4	56131	broad.mit.edu	37	5	140503432	140503432	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr5:140503432G>C	uc003lip.1	+	1	1852	c.1852G>C	c.(1852-1854)GCG>CCG	p.A618P		NM_018938	NP_061761	Q9Y5E5	PCDB4_HUMAN	protocadherin beta 4 precursor	618	Cadherin 6.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	cytoplasm|integral to plasma membrane|intermediate filament cytoskeleton	calcium ion binding			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CGGCGTGTGGGCGCACAATGG	0.687			NA											11	75					0	0	0.001368	0	0
PCDHB7	56129	broad.mit.edu	37	5	140552708	140552708	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr5:140552708C>A	uc003lit.2	+	1	466	c.292C>A	c.(292-294)CCC>ACC	p.P98T		NM_018940	NP_061763	Q9Y5E2	PCDB7_HUMAN	protocadherin beta 7 precursor	98	Extracellular (Potential).|Cadherin 1.				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|central_nervous_system(1)|skin(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			ACTGTGTGGCCCCAGAGAGCC	0.443			NA											10	139					1.58986e-06	1.91511e-06	0.008291	1	0
PCDHB9	56127	broad.mit.edu	37	5	140567414	140567414	+	Silent	SNP	C	C	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr5:140567414C>A	uc003liw.1	+	1	522	c.522C>A	c.(520-522)TCC>TCA	p.S174S		NM_019119	NP_061992	Q9Y5E1	PCDB9_HUMAN	protocadherin beta 9 precursor	174	Extracellular (Potential).|Cadherin 2.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CGATCAGCTCCAACTCTTTTT	0.418			NA											30	242					3.61848e-18	5.471e-18	0.007835	1	0
PCDHB9	56127	broad.mit.edu	37	5	140567665	140567665	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr5:140567665G>A	uc003liw.1	+	1	773	c.773G>A	c.(772-774)GGG>GAG	p.G258E		NM_019119	NP_061992	Q9Y5E1	PCDB9_HUMAN	protocadherin beta 9 precursor	258	Extracellular (Potential).|Cadherin 3.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			AGTCCAGTAGGGTCCCTTATT	0.448			NA											3	24					0	0	0.004672	0	0
PCDHGA1	56114	broad.mit.edu	37	5	140710430	140710430	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr5:140710430C>A	uc003lji.1	+	1	179	c.179C>A	c.(178-180)GCA>GAA	p.A60E	PCDHGA1_uc011dan.1_Missense_Mutation_p.A60E	NM_018912	NP_061735	Q9Y5H4	PCDG1_HUMAN	protocadherin gamma subfamily A, 1 isoform 1	60	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(1)|breast(1)|pancreas(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CAGGAGCTGGCAGATGGCGGA	0.582			NA											23	140					3.01185e-09	3.94915e-09	0.003954	1	0
PCDHGA3	56112	broad.mit.edu	37	5	140725293	140725293	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr5:140725293C>T	uc003ljm.1	+	1	1693	c.1693C>T	c.(1693-1695)CCC>TCC	p.P565S	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc010jfx.1_Missense_Mutation_p.P325S|PCDHGA3_uc011dap.1_Missense_Mutation_p.P565S	NM_018916	NP_061739	Q9Y5H0	PCDG3_HUMAN	protocadherin gamma subfamily A, 3 isoform 1	565	Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GATCCTGTACCCCGCCCTCCC	0.662			NA											31	194					0	0	0.003755	0	0
PCDHGB2	56103	broad.mit.edu	37	5	140740422	140740422	+	Silent	SNP	A	A	C			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr5:140740422A>C	uc003ljs.1	+	1	720	c.720A>C	c.(718-720)CCA>CCC	p.P240P	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc011dar.1_Silent_p.P240P	NM_018923	NP_061746	Q9Y5G2	PCDGE_HUMAN	protocadherin gamma subfamily B, 2 isoform 1	240	Extracellular (Potential).|Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ATAACCCTCCAGTGTTCAGCC	0.562			NA											20	62					0	0	0.001882	0	0
PCDHGA5	56110	broad.mit.edu	37	5	140745978	140745978	+	Missense_Mutation	SNP	T	T	C			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr5:140745978T>C	uc003lju.1	+	1	2081	c.2081T>C	c.(2080-2082)GTG>GCG	p.V694A	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc011das.1_Missense_Mutation_p.V694A	NM_018918	NP_061741	Q9Y5G8	PCDG5_HUMAN	protocadherin gamma subfamily A, 5 isoform 1	694	Helical; (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTCTATCTTGTGGTGGCAGTG	0.597			NA											14	370					0	0	0.008871	0	0
ARHGAP26	23092	broad.mit.edu	37	5	142586820	142586820	+	Silent	SNP	G	G	A	rs79503222		TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr5:142586820G>A	uc011dbj.1	+	21	2081	c.2046G>A	c.(2044-2046)GCG>GCA	p.A682A	ARHGAP26_uc003lmt.2_Silent_p.A682A|ARHGAP26_uc003lmw.2_Intron	NM_015071	NP_055886	Q9UNA1	RHG26_HUMAN	GTPase regulator associated with the focal	682	Ser-rich.				actin cytoskeleton organization|filopodium assembly|nervous system development|small GTPase mediated signal transduction	cytoskeleton|cytosol|focal adhesion	cytoskeletal adaptor activity|Rho GTPase activator activity|SH3 domain binding			ovary(1)	1		all_hematologic(541;0.0416)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			TGTTCTCGGCGCCATCCAGCC	0.557			NA											6	109					0	0	0.00308	0	0
FBXO38	81545	broad.mit.edu	37	5	147818033	147818033	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr5:147818033G>A	uc003lpf.1	+	18	3116	c.2996G>A	c.(2995-2997)CGC>CAC	p.R999H	FBXO38_uc003lpg.1_Missense_Mutation_p.R924H|FBXO38_uc003lph.2_Missense_Mutation_p.R754H	NM_205836	NP_995308	Q6PIJ6	FBX38_HUMAN	F-box protein 38 isoform b	999						cytoplasm|nucleus				ovary(4)|skin(2)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GAGAGAAACCGCATCATATAC	0.408			NA											23	71					0	0	0.00333	0	0
PPARGC1B	133522	broad.mit.edu	37	5	149216497	149216497	+	Missense_Mutation	SNP	G	G	A	rs45628534	byFrequency	TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr5:149216497G>A	uc003lrc.2	+	8	2521	c.2479G>A	c.(2479-2481)GTC>ATC	p.V827I	PPARGC1B_uc003lrb.1_Missense_Mutation_p.V827I|PPARGC1B_uc003lrd.2_Missense_Mutation_p.V788I|PPARGC1B_uc003lrf.2_Missense_Mutation_p.V806I|PPARGC1B_uc003lre.1_Missense_Mutation_p.V806I	NM_133263	NP_573570	Q86YN6	PRGC2_HUMAN	peroxisome proliferator-activated receptor	827					estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter	mediator complex	AF-2 domain binding|estrogen receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|nucleotide binding|receptor activator activity|RNA binding|RNA polymerase II transcription cofactor activity				0			KIRC - Kidney renal clear cell carcinoma(527;0.000962)|Kidney(363;0.00147)			ggaCTCAGGGGTCAGCCCCAC	0.478			NA											5	99					0	0	0.000602	0	0
FAT2	2196	broad.mit.edu	37	5	150947284	150947284	+	Silent	SNP	A	A	G			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr5:150947284A>G	uc003lue.3	-	1	1222	c.1209T>C	c.(1207-1209)AAT>AAC	p.N403N	GM2A_uc011dcs.1_Intron|FAT2_uc010jhx.1_Silent_p.N403N	NM_001447	NP_001438	Q9NYQ8	FAT2_HUMAN	FAT tumor suppressor 2 precursor	403	Extracellular (Potential).|Cadherin 3.				epithelial cell migration|homophilic cell adhesion	cell-cell adherens junction|integral to membrane|nucleus	calcium ion binding			ovary(4)|upper_aerodigestive_tract(1)|skin(1)	6		Medulloblastoma(196;0.0912)|all_hematologic(541;0.104)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			TAAATCCTACATTCTCTGAAG	0.502			NA											14	77					0	0	0.00245	0	0
G3BP1	10146	broad.mit.edu	37	5	151173720	151173720	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr5:151173720G>T	uc003lun.2	+	5	523	c.352G>T	c.(352-354)GGG>TGG	p.G118W	G3BP1_uc003lum.2_Missense_Mutation_p.G118W|G3BP1_uc011dcu.1_Intron|G3BP1_uc010jhz.2_Intron|G3BP1_uc003luq.2_5'Flank	NM_005754	NP_005745	Q13283	G3BP1_HUMAN	Ras-GTPase-activating protein SH3-domain-binding	118	NTF2.				Ras protein signal transduction|transport	cytosol|nucleus|plasma membrane	ATP binding|ATP-dependent DNA helicase activity|ATP-dependent RNA helicase activity|DNA binding|endonuclease activity|protein binding|RNA binding			skin(3)|ovary(1)	4		all_hematologic(541;0.0338)|Medulloblastoma(196;0.091)	Kidney(363;0.000171)|KIRC - Kidney renal clear cell carcinoma(527;0.000785)			GGCATTGCAGGGGTCTGTTGC	0.343			NA											6	106					0.00198382	0.00213469	0.001984	1	0
SGCD	6444	broad.mit.edu	37	5	156186354	156186354	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr5:156186354G>T	uc003lwd.3	+	8	1299	c.823G>T	c.(823-825)GCA>TCA	p.A275S	SGCD_uc003lwc.3_Missense_Mutation_p.A276S	NM_001128209	NP_001121681	Q92629	SGCD_HUMAN	delta-sarcoglycan isoform 3	275	Extracellular (Potential).				cytoskeleton organization|muscle organ development	cytoplasm|cytoskeleton|integral to membrane|sarcoglycan complex|sarcolemma					0	Renal(175;0.00488)	Medulloblastoma(196;0.0378)|all_neural(177;0.106)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			CCTGTCTCAGGCAGGAGCTGG	0.498			NA											13	100					6.31663e-08	7.95241e-08	0.003163	1	0
CPEB4	80315	broad.mit.edu	37	5	173376573	173376573	+	Nonsense_Mutation	SNP	G	G	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr5:173376573G>T	uc003mcs.3	+	6	2925	c.1519G>T	c.(1519-1521)GAG>TAG	p.E507*	CPEB4_uc010jju.1_Nonsense_Mutation_p.E482*|CPEB4_uc010jjv.2_Nonsense_Mutation_p.E490*|CPEB4_uc011dfg.1_Nonsense_Mutation_p.E482*|CPEB4_uc003mct.3_Nonsense_Mutation_p.E117*|CPEB4_uc003mcu.3_Nonsense_Mutation_p.E100*	NM_030627	NP_085130	Q17RY0	CPEB4_HUMAN	cytoplasmic polyadenylation element binding	507	RRM 1.						nucleotide binding|RNA binding				0	Renal(175;0.000159)|Lung NSC(126;0.0128)|all_lung(126;0.0202)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000183)			TCATAAAGCTGAGAGCAAATC	0.323			NA											6	79					0.00198382	0.00213469	0.001984	1	0
SNCB	6620	broad.mit.edu	37	5	176053505	176053505	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr5:176053505G>T	uc003mep.2	-	5	619	c.176C>A	c.(175-177)ACC>AAC	p.T59N	SNCB_uc003meq.2_Missense_Mutation_p.T59N|SNCB_uc010jke.1_Missense_Mutation_p.P127T	NM_001001502	NP_001001502	Q16143	SYUB_HUMAN	beta-synuclein	59	4.|4 X 11 AA tandem repeats of [EGS]-K-T-K- [EQ]-[GQ]-V-X(4).						calcium ion binding|phospholipase inhibitor activity			ovary(1)	1	all_cancers(89;0.00222)|Renal(175;0.000269)|Lung NSC(126;0.00902)|all_lung(126;0.0142)	Medulloblastoma(196;0.00498)|all_neural(177;0.0212)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CTGTTCCTTGGTTTTTTCAGC	0.592			NA											4	63					0.00909568	0.00959144	0.009096	1	0
TRIM52	84851	broad.mit.edu	37	5	180687616	180687616	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr5:180687616C>T	uc003mnp.2	-	1	504	c.199G>A	c.(199-201)GAG>AAG	p.E67K	uc003mnq.2_5'Flank	NM_032765	NP_116154	Q96A61	TRI52_HUMAN	tripartite motif-containing 52	67	Glu-rich.					intracellular	zinc ion binding				0	all_cancers(89;8.79e-06)|all_epithelial(37;1.13e-06)|Renal(175;0.000159)|Lung NSC(126;0.00354)|all_lung(126;0.00609)|Breast(19;0.0654)	all_cancers(40;0.0106)|Medulloblastoma(196;0.0392)|all_neural(177;0.0529)|all_hematologic(541;0.0588)|all_lung(500;0.149)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.232)		tcctcgtcctcctcctcctcc	0.403			NA											4	104					0	0	0.009096	0	0
SSR1	6745	broad.mit.edu	37	6	7301605	7301605	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr6:7301605C>G	uc003mxf.3	-	4	669	c.481G>C	c.(481-483)GCA>CCA	p.A161P	SSR1_uc003mxg.3_Intron|SSR1_uc010jny.2_Missense_Mutation_p.A161P	NM_003144	NP_003135	P43307	SSRA_HUMAN	signal sequence receptor, alpha precursor	161	Lumenal (Potential).				cotranslational protein targeting to membrane|positive regulation of cell proliferation	endoplasmic reticulum membrane|integral to membrane	signal sequence binding				0	Ovarian(93;0.0398)					ATGGGCTCTGCAGGAATGAAA	0.428			NA											3	73					0	0	0.004672	0	0
TFAP2A	7020	broad.mit.edu	37	6	10398916	10398916	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr6:10398916C>A	uc003myr.2	-	7	1300	c.1048G>T	c.(1048-1050)GAC>TAC	p.D350Y	TFAP2A_uc003myq.2_Missense_Mutation_p.D344Y|TFAP2A_uc003mys.2_RNA|TFAP2A_uc011dih.1_Silent_p.P302P|TFAP2A_uc003myt.2_Missense_Mutation_p.D346Y	NM_003220	NP_003211	P05549	AP2A_HUMAN	transcription factor AP-2 alpha isoform a	350	H-S-H (helix-span-helix), dimerization.				ectoderm development|positive regulation of bone mineralization|positive regulation of tooth mineralization|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter	centrosome|Golgi apparatus|nucleus	chromatin binding|protein dimerization activity|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription regulatory region DNA binding			ovary(1)	1	Breast(50;0.0427)|Ovarian(93;0.0991)	all_hematologic(90;0.107)				GCCAGCAGGTCGGTGAACTCT	0.567			NA											50	244					3.28156e-27	5.34521e-27	0.00361	1	0
PHACTR1	221692	broad.mit.edu	37	6	13206311	13206311	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr6:13206311G>A	uc010jpc.2	+	8	1261	c.929G>A	c.(928-930)TGC>TAC	p.C310Y	PHACTR1_uc011dir.1_Missense_Mutation_p.C379Y|PHACTR1_uc003nag.1_Missense_Mutation_p.C310Y|PHACTR1_uc003nah.1_Missense_Mutation_p.C310Y	NM_030948	NP_112210	Q9C0D0	PHAR1_HUMAN	phosphatase and actin regulator 1	310						cell junction|cytoplasm|synapse	actin binding|protein phosphatase inhibitor activity				0	Breast(50;0.0427)|Ovarian(93;0.12)	all_hematologic(90;0.122)|Lung SC(78;0.195)	Epithelial(50;0.146)|BRCA - Breast invasive adenocarcinoma(129;0.239)			CCCTCGGGCTGCAGAATGATA	0.637			NA											4	25					0	0	0.000602	0	0
KDM1B	221656	broad.mit.edu	37	6	18166609	18166609	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr6:18166609G>T	uc003ncn.1	+	6	658	c.417G>T	c.(415-417)TGG>TGT	p.W139C		NM_153042	NP_694587	Q8NB78	KDM1B_HUMAN	amine oxidase (flavin containing) domain 1	139	CW-type.				multicellular organismal development|regulation of DNA methylation|regulation of gene expression by genetic imprinting|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	histone demethylase activity (H3-dimethyl-K4 specific)|histone demethylase activity (H3-monomethyl-K4 specific)|oxidoreductase activity|zinc ion binding			skin(1)	1						TCCCCTACTGGGTAAGGAGAG	0.408			NA											11	54					2.27111e-07	2.78527e-07	0.001368	1	0
DCDC2	51473	broad.mit.edu	37	6	24357729	24357729	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr6:24357729C>A	uc003ndx.2	-	1	552	c.250G>T	c.(250-252)GGC>TGC	p.G84C	DCDC2_uc003ndy.2_Missense_Mutation_p.G84C|KAAG1_uc003ndz.1_5'UTR	NM_016356	NP_057440	Q9UHG0	DCDC2_HUMAN	doublecortin domain containing 2	84	Doublecortin 1.				cellular defense response|intracellular signal transduction|neuron migration					ovary(1)	1		Ovarian(999;0.101)				ACGTAATTGCCCCCGCTCTGG	0.612			NA											13	61					1.05317e-09	1.40819e-09	0.00245	1	0
HIST1H1B	3009	broad.mit.edu	37	6	27835161	27835161	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr6:27835161C>A	uc003njx.2	-	1	199	c.147G>T	c.(145-147)AAG>AAT	p.K49N		NM_005322	NP_005313	P16401	H15_HUMAN	histone cluster 1, H1b	49	H15.				nucleosome assembly	nucleosome|nucleus	DNA binding			large_intestine(2)|lung(1)	3						CAGCCACAGCCTTGGTGATCA	0.592			NA											7	159					0.00307968	0.00329147	0.00308	1	0
ZFP57	346171	broad.mit.edu	37	6	29643264	29643264	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr6:29643264G>A	uc011dlw.1	-	3	402	c.251C>T	c.(250-252)GCC>GTC	p.A84V	ZFP57_uc003nnl.3_Missense_Mutation_p.A64V	NM_001109809	NP_001103279	Q9NU63	ZFP57_HUMAN	zinc finger protein 57 homolog	56	KRAB.				DNA methylation involved in embryo development|regulation of gene expression by genetic imprinting|transcription, DNA-dependent		DNA binding|zinc ion binding			ovary(3)|skin(2)	5						AAAGATTCTGGCTGATGTGTG	0.478			NA											19	187					0	0	0.006122	0	0
PPP1R10	5514	broad.mit.edu	37	6	30571379	30571379	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr6:30571379G>T	uc003nqn.1	-	16	2189	c.1637C>A	c.(1636-1638)CCT>CAT	p.P546H	PPP1R10_uc010jsc.1_Missense_Mutation_p.P200H	NM_002714	NP_002705	Q96QC0	PP1RA_HUMAN	protein phosphatase 1, regulatory subunit 10	546	Gly-rich.|Interaction with WDR82 (By similarity).				protein import into nucleus|transcription, DNA-dependent	PTW/PP1 phosphatase complex	DNA binding|protein phosphatase inhibitor activity|RNA binding|zinc ion binding			ovary(2)|lung(1)|kidney(1)	4						TGCCCCATCAGGTGAGCCACC	0.537			NA											33	224					6.03168e-27	9.80795e-27	0.004878	1	0
PPT2	9374	broad.mit.edu	37	6	32125471	32125471	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr6:32125471G>C	uc003nzx.2	+	6	1167	c.599G>C	c.(598-600)GGG>GCG	p.G200A	PPT2_uc003nzw.2_Missense_Mutation_p.G206A|PPT2_uc011dpi.1_RNA|PPT2_uc003nzy.1_RNA|PPT2_uc003nzz.2_Missense_Mutation_p.G200A|PPT2_uc003oaa.2_Missense_Mutation_p.G200A|PPT2_uc010jtu.1_Missense_Mutation_p.G200A	NM_005155	NP_005146	Q9UMR5	PPT2_HUMAN	palmitoyl-protein thioesterase 2 isoform a	200					protein modification process	lysosome	palmitoyl-(protein) hydrolase activity				0						CTGATCAATGGGGAAAGAGAC	0.507			NA											3	77					0	0	0.009096	0	0
NOTCH4	4855	broad.mit.edu	37	6	32169153	32169153	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr6:32169153C>G	uc003obb.2	-	22	4019	c.3880G>C	c.(3880-3882)GGG>CGG	p.G1294R	NOTCH4_uc003oba.2_5'UTR|NOTCH4_uc011dpu.1_RNA|NOTCH4_uc011dpv.1_RNA	NM_004557	NP_004548	Q99466	NOTC4_HUMAN	notch4 preproprotein	1294	LNR 3.|Extracellular (Potential).				cell fate determination|embryo development|hemopoiesis|mammary gland development|negative regulation of endothelial cell differentiation|Notch receptor processing|Notch signaling pathway|patterning of blood vessels|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|protein heterodimerization activity|receptor activity			lung(8)|ovary(5)|breast(4)|central_nervous_system(3)|upper_aerodigestive_tract(1)|skin(1)	22						AGGGAGGGCCCCCACTCTGGG	0.632			NA											16	46					0	0	0.001882	0	0
C6orf222	389384	broad.mit.edu	37	6	36285159	36285159	+	Missense_Mutation	SNP	T	T	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr6:36285159T>A	uc003oly.2	-	12	2111	c.1933A>T	c.(1933-1935)AGT>TGT	p.S645C		NM_001010903	NP_001010903	P0C671	CF222_HUMAN	hypothetical protein LOC389384	645										skin(2)|ovary(1)|breast(1)	4						ACCTTAGGACTTGTGATGTTC	0.423			NA											7	156					0	0	0.00308	0	0
DNAH8	1769	broad.mit.edu	37	6	38775449	38775449	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr6:38775449C>T	uc003ooe.1	+	22	3163	c.2563C>T	c.(2563-2565)CGG>TGG	p.R855W		NM_001371	NP_001362			dynein, axonemal, heavy polypeptide 8											skin(8)|ovary(7)|lung(2)|large_intestine(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	21						AAAAGCTACACGGTTATCTCT	0.328			NA											20	108					0	0	0.010504	0	0
DNAH8	1769	broad.mit.edu	37	6	38850818	38850818	+	Missense_Mutation	SNP	A	A	G			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr6:38850818A>G	uc003ooe.1	+	52	7940	c.7340A>G	c.(7339-7341)AAA>AGA	p.K2447R		NM_001371	NP_001362			dynein, axonemal, heavy polypeptide 8											skin(8)|ovary(7)|lung(2)|large_intestine(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	21						ACCATTGCAAAACAACATAAA	0.323			NA											4	107					0	0	0.000602	0	0
HSP90AB1	3326	broad.mit.edu	37	6	44221076	44221076	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr6:44221076C>T	uc003oxa.1	+	11	2110	c.2026C>T	c.(2026-2028)CAC>TAC	p.H676Y	HSP90AB1_uc011dvr.1_Missense_Mutation_p.H666Y|HSP90AB1_uc003oxb.1_Missense_Mutation_p.H676Y|HSP90AB1_uc011dvs.1_Missense_Mutation_p.H496Y|HSP90AB1_uc003oxc.1_Missense_Mutation_p.H314Y	NM_007355	NP_031381	P08238	HS90B_HUMAN	heat shock 90kDa protein 1, beta	676					axon guidance|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of nitric oxide biosynthetic process|protein folding|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|response to unfolded protein	cytosol|melanosome	ATP binding|nitric-oxide synthase regulator activity|TPR domain binding|unfolded protein binding			lung(3)|breast(1)	4	all_cancers(18;1.7e-05)|all_lung(25;0.00747)|Hepatocellular(11;0.00908)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)			TCCCCAGACCCACTCCAACCG	0.502			NA											75	466					0	0	0.00361	0	0
TCTE1	202500	broad.mit.edu	37	6	44255481	44255481	+	Nonsense_Mutation	SNP	C	C	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr6:44255481C>A	uc003oxi.2	-	2	238	c.82G>T	c.(82-84)GGA>TGA	p.G28*	SPATS1_uc003oxg.2_Intron|TMEM151B_uc003oxf.2_Intron	NM_182539	NP_872345	Q5JU00	TCTE1_HUMAN	t-complex-associated testis expressed 1	28										ovary(2)|skin(2)	4	Hepatocellular(11;0.00908)|all_lung(25;0.0101)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)			GAAGTGTGTCCTCCAGTGGAG	0.552			NA											13	70					7.03913e-09	9.14122e-09	0.001368	1	0
GPR115	221393	broad.mit.edu	37	6	47676002	47676002	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr6:47676002G>A	uc003oza.1	+	3	394	c.136G>A	c.(136-138)GGA>AGA	p.G46R	GPR115_uc003oyz.1_Missense_Mutation_p.G103R|GPR115_uc003ozb.1_Missense_Mutation_p.G44R	NM_153838	NP_722580	Q8IZF3	GP115_HUMAN	G-protein coupled receptor 115 precursor	46	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(3)|skin(3)|upper_aerodigestive_tract(1)|breast(1)	8						ACCCAAGACTGGAAGGATCCA	0.458	GBM(22;431 510 9010 26644 32828)		NA											16	41					0	0	0.010504	0	0
MUT	4594	broad.mit.edu	37	6	49403211	49403211	+	Silent	SNP	C	C	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr6:49403211C>T	uc003ozg.3	-	12	2337	c.2082G>A	c.(2080-2082)CGG>CGA	p.R694R		NM_000255	NP_000246	P22033	MUTA_HUMAN	methylmalonyl Coenzyme A mutase precursor	694	B12-binding.		R -> W (in MMAM; mut- and mut0).		fatty acid beta-oxidation	mitochondrial matrix	cobalamin binding|metal ion binding|methylmalonyl-CoA mutase activity				0	Lung NSC(77;0.0376)				Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	GAATATCTGGCCGTCCAAGGG	0.448			NA											4	56					0	0	0.009096	0	0
TINAG	27283	broad.mit.edu	37	6	54185441	54185441	+	Splice_Site	SNP	G	G	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr6:54185441G>T	uc003pcj.2	+	2	565	c.419_splice	c.e2+1	p.C140_splice	TINAG_uc003pci.2_Missense_Mutation_p.W140C|TINAG_uc010jzt.2_Intron	NM_014464	NP_055279	Q9UJW2	TINAG_HUMAN	tubulointerstitial nephritis antigen						cell adhesion|immune response|Malpighian tubule morphogenesis|proteolysis	basement membrane	cysteine-type endopeptidase activity|nucleotide binding|polysaccharide binding|scavenger receptor activity			ovary(3)|central_nervous_system(1)	4	Lung NSC(77;0.0518)		LUSC - Lung squamous cell carcinoma(124;0.246)			GCAACTCCTGGTAATAAATTT	0.308			NA											29	54					2.81731e-10	3.83738e-10	0.002096	1	0
COL9A1	1297	broad.mit.edu	37	6	70961991	70961991	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr6:70961991C>A	uc003pfg.3	-	27	1951	c.1792G>T	c.(1792-1794)GGT>TGT	p.G598C	COL9A1_uc003pfe.3_Missense_Mutation_p.G171C|COL9A1_uc003pff.3_Missense_Mutation_p.G355C	NM_001851	NP_001842	P20849	CO9A1_HUMAN	alpha 1 type IX collagen isoform 1 precursor	598	Triple-helical region (COL2).				axon guidance|cell adhesion|organ morphogenesis	collagen type IX	metal ion binding			ovary(4)	4						CCCATCTGACCAGGCTTCCCT	0.428			NA											7	85					0.00307968	0.00329147	0.00308	1	0
CD109	135228	broad.mit.edu	37	6	74407145	74407145	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr6:74407145C>A	uc003php.2	+	2	522	c.97C>A	c.(97-99)CCA>ACA	p.P33T	CD109_uc010kaz.2_Missense_Mutation_p.P33T|CD109_uc003phq.2_Missense_Mutation_p.P33T|CD109_uc010kba.2_Missense_Mutation_p.P33T|uc003pho.1_5'Flank	NM_133493	NP_598000	Q6YHK3	CD109_HUMAN	CD109 antigen isoform 1 precursor	33						anchored to membrane|extracellular space|plasma membrane	serine-type endopeptidase inhibitor activity			large_intestine(2)|ovary(2)	4						GGTGACAGCCCCAGGGATCAT	0.507			NA											22	133					7.33628e-21	1.14576e-20	0.002299	1	0
TMEM30A	55754	broad.mit.edu	37	6	75969072	75969072	+	Nonsense_Mutation	SNP	G	G	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr6:75969072G>A	uc003phw.2	-	5	954	c.676C>T	c.(676-678)CGA>TGA	p.R226*	TMEM30A_uc003phx.2_Nonsense_Mutation_p.R190*	NM_018247	NP_060717	Q9NV96	CC50A_HUMAN	transmembrane protein 30A isoform 1	226						integral to membrane					0						CCTTTAAATCGTTCTTCCAGG	0.308			NA											42	112					0	0	0.00361	0	0
IMPG1	3617	broad.mit.edu	37	6	76751728	76751728	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr6:76751728G>T	uc003pik.1	-	2	313	c.183C>A	c.(181-183)TTC>TTA	p.F61L		NM_001563	NP_001554	Q17R60	IMPG1_HUMAN	interphotoreceptor matrix proteoglycan 1	61					visual perception	proteinaceous extracellular matrix	extracellular matrix structural constituent|receptor activity			ovary(2)|skin(1)	3		Acute lymphoblastic leukemia(125;0.0418)|all_hematologic(105;0.222)				TTGCCAAATCGAATATTCGTC	0.368	Pancreas(37;839 1141 2599 26037)		NA											54	85					2.31418e-15	3.43325e-15	0.00361	1	0
SPACA1	81833	broad.mit.edu	37	6	88773939	88773939	+	Splice_Site	SNP	T	T	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr6:88773939T>A	uc003pmn.2	+	6	848	c.731_splice	c.e6+2	p.W244_splice		NM_030960	NP_112222	Q9HBV2	SACA1_HUMAN	sperm acrosome associated 1 precursor							integral to membrane					0		all_cancers(76;8.24e-09)|Acute lymphoblastic leukemia(125;2.15e-10)|Prostate(29;4.11e-10)|all_hematologic(105;1.08e-06)|all_epithelial(107;0.00011)		BRCA - Breast invasive adenocarcinoma(108;0.11)		CATAAATTGGTAGGTGAATAG	0.413			NA											11	101					0	0	0.001855	0	0
CASP8AP2	9994	broad.mit.edu	37	6	90577282	90577282	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr6:90577282G>T	uc003pnr.2	+	8	4469	c.4273G>T	c.(4273-4275)GTA>TTA	p.V1425L	CASP8AP2_uc003pns.2_Intron|CASP8AP2_uc003pnt.2_Missense_Mutation_p.V1425L|CASP8AP2_uc011dzz.1_Missense_Mutation_p.V1425L	NM_001137667	NP_001131139	Q9UKL3	C8AP2_HUMAN	caspase 8 associated protein 2	1425					cell cycle|cellular response to mechanical stimulus|induction of apoptosis via death domain receptors|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	cytoplasm|nucleus	caspase activator activity|death receptor binding|transcription corepressor activity			ovary(2)	2		all_cancers(76;3.64e-09)|Prostate(29;1.16e-10)|Acute lymphoblastic leukemia(125;1.45e-10)|all_hematologic(105;7.74e-07)|all_epithelial(107;4.69e-05)|Lung NSC(302;0.238)		BRCA - Breast invasive adenocarcinoma(108;0.0953)		TGTGTGTAGTGTAGAAAAGAG	0.408	Colon(187;1656 2025 17045 31481 39901)		NA											36	75					4.11147e-13	5.92352e-13	0.003755	1	0
FHL5	9457	broad.mit.edu	37	6	97058635	97058635	+	Splice_Site	SNP	G	G	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr6:97058635G>T	uc003pos.1	+	6	1096	c.691_splice	c.e6+1	p.G231_splice	FHL5_uc003pot.1_Splice_Site_p.G231_splice	NM_020482	NP_065228	Q5TD97	FHL5_HUMAN	activator of cAMP-responsive element modulator							nucleus	zinc ion binding			ovary(2)	2		all_cancers(76;1.57e-07)|Acute lymphoblastic leukemia(125;4.93e-10)|all_hematologic(75;3.55e-07)|all_epithelial(107;0.00266)|Colorectal(196;0.0341)|Lung NSC(302;0.204)		BRCA - Breast invasive adenocarcinoma(108;0.0948)		CCCATTAGTGGTGAGTTCTTC	0.388			NA											22	115					5.35356e-11	7.40901e-11	0.00278	1	0
ASCC3	10973	broad.mit.edu	37	6	101053528	101053528	+	Missense_Mutation	SNP	T	T	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr6:101053528T>A	uc003pqk.2	-	33	5422	c.5093A>T	c.(5092-5094)CAA>CTA	p.Q1698L		NM_006828	NP_006819	Q8N3C0	HELC1_HUMAN	activating signal cointegrator 1 complex subunit	1698	Helicase C-terminal 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|microtubule cytoskeleton	ATP binding|ATP-dependent helicase activity|nucleic acid binding			ovary(5)|skin(1)	6		all_cancers(76;1.45e-07)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(87;0.00149)|Hepatocellular(1;0.0893)|Colorectal(196;0.13)		BRCA - Breast invasive adenocarcinoma(108;0.0539)|all cancers(137;0.103)|GBM - Glioblastoma multiforme(226;0.199)		AGCTTTGCCTTGGTCATCGAA	0.373			NA											8	32					0	0	0.00308	0	0
HDAC2	3066	broad.mit.edu	37	6	114281153	114281153	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr6:114281153C>G	uc003pwd.1	-	2	364	c.364G>C	c.(364-366)GGT>CGT	p.G122R	HDAC2_uc003pwc.1_5'UTR|HDAC2_uc003pwe.1_5'UTR	NM_001527	NP_001518	Q92769	HDAC2_HUMAN	histone deacetylase 2	28	Histone deacetylase.				blood coagulation|dendrite development|embryonic digit morphogenesis|epidermal cell differentiation|eyelid development in camera-type eye|fungiform papilla formation|hair follicle placode formation|maintenance of chromatin silencing|negative regulation of apoptosis|negative regulation of cell cycle|negative regulation of neuron projection development|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|nerve growth factor receptor signaling pathway|odontogenesis of dentine-containing tooth|positive regulation of cell proliferation|positive regulation of proteolysis|positive regulation of receptor biosynthetic process|positive regulation of transcription from RNA polymerase II promoter	cytoplasm|ESC/E(Z) complex|NuRD complex|Sin3 complex	chromatin binding|enzyme binding|histone deacetylase activity (H3-K16 specific)|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|sequence-specific DNA binding|transcription factor binding			skin(2)|ovary(1)|central_nervous_system(1)	4		all_cancers(87;0.000629)|all_epithelial(87;0.00274)|Colorectal(196;0.0317)|all_lung(197;0.24)		all cancers(137;0.00318)|OV - Ovarian serous cystadenocarcinoma(136;0.00569)|Epithelial(106;0.0112)|GBM - Glioblastoma multiforme(226;0.0832)	Vorinostat(DB02546)	ATGGGATGACCCTGTCCATAA	0.323			NA											4	100					0	0	0.001168	0	0
HS3ST5	222537	broad.mit.edu	37	6	114378677	114378677	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr6:114378677G>T	uc003pwg.3	-	2	817	c.785C>A	c.(784-786)CCT>CAT	p.P262H	uc003pwf.2_Intron|HS3ST5_uc003pwh.3_Missense_Mutation_p.P262H	NM_153612	NP_705840	Q8IZT8	HS3S5_HUMAN	heparan sulfate (glucosamine)	262	Lumenal (Potential).				heparan sulfate proteoglycan biosynthetic process, enzymatic modification|negative regulation of coagulation|protein sulfation|regulation of virion penetration into host cell	Golgi membrane|integral to membrane	3'-phosphoadenosine 5'-phosphosulfate binding|[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity|protein binding			ovary(1)|pancreas(1)	2		all_cancers(87;0.0587)|Colorectal(196;0.0676)|all_epithelial(87;0.154)		OV - Ovarian serous cystadenocarcinoma(136;0.00937)|all cancers(137;0.0117)|Epithelial(106;0.0274)|GBM - Glioblastoma multiforme(226;0.143)		TTCTGGCAGAGGTTCCGTGAT	0.433			NA											43	118					1.22674e-20	1.90961e-20	0.00874	1	0
GPRC6A	222545	broad.mit.edu	37	6	117114013	117114013	+	Missense_Mutation	SNP	A	A	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr6:117114013A>T	uc003pxj.1	-	6	2095	c.2073T>A	c.(2071-2073)GAT>GAA	p.D691E	GPRC6A_uc003pxk.1_Missense_Mutation_p.D516E|GPRC6A_uc003pxl.1_Missense_Mutation_p.D620E	NM_148963	NP_683766	Q5T6X5	GPC6A_HUMAN	G protein-coupled receptor, family C, group 6,	691	Cytoplasmic (Potential).				response to amino acid stimulus		G-protein coupled receptor activity			ovary(4)|skin(2)	6		all_cancers(87;0.0314)|all_epithelial(87;0.0216)|Colorectal(196;0.234)		GBM - Glioblastoma multiforme(226;0.0265)|all cancers(137;0.0554)|OV - Ovarian serous cystadenocarcinoma(136;0.07)		GTAATTTGGGATCAAAGCTGA	0.418			NA											22	66					0	0	0.001882	0	0
SLC35F1	222553	broad.mit.edu	37	6	118475609	118475609	+	Nonsense_Mutation	SNP	G	G	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr6:118475609G>T	uc003pxx.3	+	2	376	c.175G>T	c.(175-177)GAG>TAG	p.E59*		NM_001029858	NP_001025029	Q5T1Q4	S35F1_HUMAN	solute carrier family 35, member F1	59					transport	integral to membrane				breast(1)	1				GBM - Glioblastoma multiforme(226;0.217)		ATTTCTCAGGGAGATGTTAAT	0.338			NA											17	183					5.3912e-06	6.39657e-06	0.006122	1	0
LAMA2	3908	broad.mit.edu	37	6	129571288	129571289	+	Missense_Mutation	DNP	CC	CC	AA	rs112388307	byFrequency	TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr6:129571288_129571289CC>AA	uc003qbn.2	+	13	1919_1920	c.1814_1815CC>AA	c.(1813-1815)ACC>AAA	p.T605K	LAMA2_uc003qbo.2_Missense_Mutation_p.T605K	NM_000426	NP_000417	P24043	LAMA2_HUMAN	laminin alpha 2 subunit isoform a precursor	605	Laminin IV type A 1.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|breast(1)|skin(1)	10				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		TTGACATTTACCATATCATATG	0.401			NA											56	100					0	0	0.004672	0	0
LAMA2	3908	broad.mit.edu	37	6	129833584	129833584	+	Silent	SNP	G	G	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr6:129833584G>A	uc003qbn.2	+	62	9039	c.8934G>A	c.(8932-8934)CTG>CTA	p.L2978L	LAMA2_uc003qbo.2_Silent_p.L2974L|uc003qbq.2_Intron	NM_000426	NP_000417	P24043	LAMA2_HUMAN	laminin alpha 2 subunit isoform a precursor	2978	Laminin G-like 5.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|breast(1)|skin(1)	10				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		GAGTTCTTCTGGGGATCAGTA	0.358			NA											21	225					0	0	0.003954	0	0
TAAR6	319100	broad.mit.edu	37	6	132891677	132891677	+	Missense_Mutation	SNP	T	T	C			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr6:132891677T>C	uc011eck.1	+	1	217	c.217T>C	c.(217-219)TCT>CCT	p.S73P		NM_175067	NP_778237	Q96RI8	TAAR6_HUMAN	trace amine associated receptor 6	73	Helical; Name=2; (Potential).					plasma membrane	G-protein coupled receptor activity			ovary(2)|skin(1)	3	Breast(56;0.112)			OV - Ovarian serous cystadenocarcinoma(155;0.006)|GBM - Glioblastoma multiforme(226;0.00792)		TCTCGTTGCCTCTCTGGCCTG	0.522			NA											39	157					0	0	0.002522	0	0
ALDH8A1	64577	broad.mit.edu	37	6	135253996	135253996	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr6:135253996C>T	uc003qew.2	-	5	820	c.767G>A	c.(766-768)GGC>GAC	p.G256D	ALDH8A1_uc003qex.2_Missense_Mutation_p.G256D|ALDH8A1_uc010kgh.2_Missense_Mutation_p.G88D|ALDH8A1_uc011ecx.1_Missense_Mutation_p.G206D	NM_022568	NP_072090	Q9H2A2	AL8A1_HUMAN	aldehyde dehydrogenase 8A1 isoform 1	256					retinal metabolic process	cytoplasm	retinal dehydrogenase activity			ovary(2)|pancreas(1)|skin(1)	4	Colorectal(23;0.221)			OV - Ovarian serous cystadenocarcinoma(155;0.00401)|GBM - Glioblastoma multiforme(68;0.0058)		AGGATTCTTGCCCCCCAGCTC	0.622			NA											5	135					0	0	0.000602	0	0
BCLAF1	9774	broad.mit.edu	37	6	136597009	136597009	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr6:136597009C>A	uc003qgx.1	-	5	1907	c.1654G>T	c.(1654-1656)GCA>TCA	p.A552S	BCLAF1_uc003qgw.1_Missense_Mutation_p.A379S|BCLAF1_uc003qgy.1_Missense_Mutation_p.A550S|BCLAF1_uc011edc.1_RNA|BCLAF1_uc011edd.1_RNA|BCLAF1_uc011ede.1_Missense_Mutation_p.A550S	NM_014739	NP_055554	Q9NYF8	BCLF1_HUMAN	BCL2-associated transcription factor 1 isoform	552					induction of apoptosis|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding			ovary(1)	1	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00226)|OV - Ovarian serous cystadenocarcinoma(155;0.00331)		GGAACAGGTGCCATTTTGAGT	0.403	Colon(142;1534 1789 5427 7063 28491)		NA											17	281					2.94398e-08	3.7512e-08	0.007413	1	0
HIVEP2	3097	broad.mit.edu	37	6	143091689	143091690	+	Missense_Mutation	DNP	CC	CC	AA			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr6:143091689_143091690CC>AA	uc003qjd.2	-	5	4929_4930	c.4186_4187GG>TT	c.(4186-4188)GGG>TTG	p.G1396L		NM_006734	NP_006725	P31629	ZEP2_HUMAN	human immunodeficiency virus type I enhancer	1396					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)|skin(2)|central_nervous_system(1)	6				OV - Ovarian serous cystadenocarcinoma(155;1.61e-05)|GBM - Glioblastoma multiforme(68;0.0102)		CGCATGCTGCCCCAGCACCTGG	0.52	Esophageal Squamous(107;843 1510 13293 16805 42198)		NA											11	80					0	0	0.004672	0	0
UTRN	7402	broad.mit.edu	37	6	144863971	144863971	+	Missense_Mutation	SNP	A	A	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr6:144863971A>T	uc003qkt.2	+	45	6652	c.6560A>T	c.(6559-6561)CAG>CTG	p.Q2187L		NM_007124	NP_009055	P46939	UTRO_HUMAN	utrophin	2187					muscle contraction|muscle organ development|positive regulation of cell-matrix adhesion	cell junction|cytoplasm|cytoskeleton|membrane fraction|nucleus|postsynaptic membrane	actin binding|calcium ion binding|zinc ion binding			ovary(4)|pancreas(1)	5		Ovarian(120;0.218)		OV - Ovarian serous cystadenocarcinoma(155;5.72e-07)|GBM - Glioblastoma multiforme(68;4.9e-05)|Colorectal(48;0.213)		GAATGCATCCAGGAGCCCAGT	0.368			NA											3	38					0	0	0.009096	0	0
GRM1	2911	broad.mit.edu	37	6	146720216	146720216	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr6:146720216C>G	uc010khw.1	+	8	2511	c.2041C>G	c.(2041-2043)CGT>GGT	p.R681G	GRM1_uc010khv.1_Missense_Mutation_p.R681G|GRM1_uc003qll.2_Missense_Mutation_p.R681G|GRM1_uc011edz.1_Missense_Mutation_p.R681G|GRM1_uc011eea.1_Missense_Mutation_p.R681G	NM_000838	NP_000829	Q13255	GRM1_HUMAN	glutamate receptor, metabotropic 1 isoform alpha	681	Cytoplasmic (Potential).				synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			lung(8)|ovary(4)|central_nervous_system(3)|large_intestine(2)|breast(2)	19		Ovarian(120;0.0387)		OV - Ovarian serous cystadenocarcinoma(155;5.35e-08)|GBM - Glioblastoma multiforme(68;0.00762)	Acamprosate(DB00659)|L-Glutamic Acid(DB00142)	TAAAACCAATCGTATTGCACG	0.527			NA											5	376					0	0	0.000602	0	0
SASH1	23328	broad.mit.edu	37	6	148855994	148855994	+	Missense_Mutation	SNP	A	A	C			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr6:148855994A>C	uc003qme.1	+	16	2527	c.2052A>C	c.(2050-2052)AGA>AGC	p.R684S	SASH1_uc011eeb.1_Missense_Mutation_p.R445S|SASH1_uc003qmf.1_Missense_Mutation_p.R94S	NM_015278	NP_056093	O94885	SASH1_HUMAN	SAM and SH3 domain containing 1	684	SAM 1.						protein binding			central_nervous_system(1)	1		Ovarian(120;0.0169)		OV - Ovarian serous cystadenocarcinoma(155;5.63e-11)|GBM - Glioblastoma multiforme(68;0.0701)		CGGAACACAGAGCTGTTCTCT	0.498			NA											31	101					0	0	0.002096	0	0
TAB2	23118	broad.mit.edu	37	6	149700627	149700627	+	Nonsense_Mutation	SNP	G	G	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr6:149700627G>T	uc003qmj.2	+	3	1754	c.1576G>T	c.(1576-1578)GGA>TGA	p.G526*	TAB2_uc011eec.1_Nonsense_Mutation_p.G494*|TAB2_uc010kia.1_Nonsense_Mutation_p.G526*|TAB2_uc010kib.1_Nonsense_Mutation_p.G526*|TAB2_uc003qmk.3_RNA	NM_015093	NP_055908	Q9NYJ8	TAB2_HUMAN	mitogen-activated protein kinase kinase kinase 7	526					activation of MAPK activity|heart development|I-kappaB kinase/NF-kappaB cascade|innate immune response|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|stress-activated MAPK cascade|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|endosome membrane|plasma membrane	K63-linked polyubiquitin binding|zinc ion binding				0						ACTGAGTATGGGATCTGATGA	0.418			NA											49	107					6.23363e-37	1.02774e-36	0.00361	1	0
TTLL2	83887	broad.mit.edu	37	6	167754801	167754801	+	Silent	SNP	G	G	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr6:167754801G>A	uc003qvs.1	+	3	1501	c.1413G>A	c.(1411-1413)GTG>GTA	p.V471V	TTLL2_uc011egr.1_RNA	NM_031949	NP_114155	Q9BWV7	TTLL2_HUMAN	tubulin tyrosine ligase-like family, member 2	471					protein modification process		ATP binding|tubulin-tyrosine ligase activity			ovary(1)|central_nervous_system(1)|skin(1)	3		Breast(66;7.8e-06)|Ovarian(120;0.024)		OV - Ovarian serous cystadenocarcinoma(33;2.22e-20)|BRCA - Breast invasive adenocarcinoma(81;6.17e-07)|GBM - Glioblastoma multiforme(31;0.00492)		ATGACTCTGTGGTGGAGAAAG	0.507			NA											13	99					0	0	0.004007	0	0
SDK1	221935	broad.mit.edu	37	7	4153888	4153888	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr7:4153888G>T	uc003smx.2	+	25	3944	c.3805G>T	c.(3805-3807)GGC>TGC	p.G1269C	SDK1_uc010kso.2_Missense_Mutation_p.G545C	NM_152744	NP_689957	Q7Z5N4	SDK1_HUMAN	sidekick 1 precursor	1269	Fibronectin type-III 6.				cell adhesion	integral to membrane				large_intestine(3)|ovary(2)|skin(1)	6		all_cancers(1;0.127)|Ovarian(82;0.0177)|Myeloproliferative disorder(862;0.194)		UCEC - Uterine corpus endometrioid carcinoma (126;0.121)|OV - Ovarian serous cystadenocarcinoma(56;9.65e-15)		GGTGGTGCGGGGCCGGACGCG	0.637			NA											6	18					2.0095e-06	2.40531e-06	0.001984	1	0
WIPI2	26100	broad.mit.edu	37	7	5239290	5239290	+	Splice_Site	SNP	G	G	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr7:5239290G>A	uc003snv.2	+	3	427	c.211_splice	c.e3+1	p.T71_splice	WIPI2_uc003snw.2_Splice_Site_p.T71_splice|WIPI2_uc003snx.2_Splice_Site_p.T53_splice|WIPI2_uc003sny.2_Splice_Site_p.T53_splice|WIPI2_uc010ksv.2_Splice_Site	NM_015610	NP_056425	Q9Y4P8	WIPI2_HUMAN	WD repeat domain, phosphoinositide interacting 2						autophagic vacuole assembly	cytosol|PAS complex|pre-autophagosomal structure membrane	phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding			ovary(2)	2		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0925)|OV - Ovarian serous cystadenocarcinoma(56;2.59e-14)		TATGAATGCAGTAAGTGTTTG	0.363			NA											5	174					0	0	0.001168	0	0
NDUFA4	4697	broad.mit.edu	37	7	10978447	10978447	+	Missense_Mutation	SNP	T	T	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr7:10978447T>A	uc003srx.1	-	2	248	c.119A>T	c.(118-120)AAT>ATT	p.N40I		NM_002489	NP_002480	O00483	NDUA4_HUMAN	NADH dehydrogenase (ubiquinone) 1 alpha	40					mitochondrial electron transport, NADH to ubiquinone|transport	mitochondrial respiratory chain complex I	NADH dehydrogenase (ubiquinone) activity				0				UCEC - Uterine corpus endometrioid carcinoma (126;0.177)	NADH(DB00157)	AACATCTGGATTGAACAATGC	0.343			NA											3	68					0	0	0.004672	0	0
ETV1	2115	broad.mit.edu	37	7	13971169	13971169	+	Silent	SNP	G	G	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr7:13971169G>A	uc011jxq.1	-	9	1499	c.760C>T	c.(760-762)CTG>TTG	p.L254L	ETV1_uc011jxn.1_Silent_p.L214L|ETV1_uc011jxo.1_Silent_p.L151L|ETV1_uc011jxp.1_Silent_p.L196L|ETV1_uc003ssw.3_Silent_p.L254L|ETV1_uc003ssx.2_RNA|ETV1_uc011jxr.1_Silent_p.L236L|ETV1_uc011jxs.1_Silent_p.L236L|ETV1_uc010ktv.2_Silent_p.L123L	NM_004956	NP_004947	P50549	ETV1_HUMAN	ets variant gene 1 isoform a	254					transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		TMPRSS2/ETV1(24)|EWSR1/ETV1(7)	prostate(24)|soft_tissue(4)|bone(3)|lung(2)|central_nervous_system(1)|ovary(1)	35						TTAATCATCAGAGGAGGGGGA	0.512			NA	T	EWSR1|TMPRSS2|SLC45A3|C15orf21|HNRNPA2B1. ACSL3	Ewing sarcoma|prostate								7	67					0	0	0.00308	0	0
HOXA7	3204	broad.mit.edu	37	7	27196009	27196009	+	Silent	SNP	C	C	G			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr7:27196009C>G	uc003sys.2	-	1	288	c.156G>C	c.(154-156)CCG>CCC	p.P52P		NM_006896	NP_008827	P31268	HXA7_HUMAN	homeobox A7	52					angiogenesis|negative regulation of cell-matrix adhesion|negative regulation of keratinocyte differentiation|negative regulation of leukocyte migration|negative regulation of monocyte differentiation|negative regulation of transcription from RNA polymerase II promoter		sequence-specific DNA binding|transcription factor binding				0						TGTATAAGCCCGGAACGGTCG	0.642			NA											8	90					0	0	0.004482	0	0
HOXA10	3206	broad.mit.edu	37	7	27213858	27213858	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr7:27213858C>A	uc011jzm.1	-	1	98	c.68G>T	c.(67-69)AGC>ATC	p.S23I	HOXA10_uc003syw.3_Intron	NM_018951	NP_061824	P31260	HXA10_HUMAN	homeobox A10 isoform a	23					spermatogenesis		protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						CGCGGCGGGGCTCTCCGAGCA	0.413			NA											8	25					0.000673444	0.000742355	0.008291	1	0
EVX1	2128	broad.mit.edu	37	7	27284799	27284799	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr7:27284799G>T	uc003szd.1	+	2	1046	c.560G>T	c.(559-561)CGC>CTC	p.R187L	EVX1_uc011jzn.1_Missense_Mutation_p.R5L|EVX1_uc010kuy.1_Missense_Mutation_p.A169S	NM_001989	NP_001980	P49640	EVX1_HUMAN	even-skipped homeobox 1	187	Homeobox.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			skin(1)	1						CGTCGTTACCGCACCGCCTTC	0.662			NA											22	84					1.55469e-16	2.32836e-16	0.00333	1	0
HECW1	23072	broad.mit.edu	37	7	43484383	43484383	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr7:43484383C>A	uc003tid.1	+	11	2217	c.1612C>A	c.(1612-1614)CCT>ACT	p.P538T	HECW1_uc011kbi.1_Missense_Mutation_p.P538T	NM_015052	NP_055867	Q76N89	HECW1_HUMAN	NEDD4-like ubiquitin-protein ligase 1	538					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	ubiquitin-protein ligase activity			ovary(8)|lung(6)|breast(4)|skin(4)|pancreas(1)	23						CTGCTCCTTGCCTGTGTCCGA	0.597			NA											14	48					1.15088e-07	1.42432e-07	0.004007	1	0
CCM2	83605	broad.mit.edu	37	7	45108125	45108125	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr7:45108125G>A	uc003tmo.2	+	5	702	c.556G>A	c.(556-558)GCA>ACA	p.A186T	CCM2_uc003tmn.2_RNA|CCM2_uc003tmp.2_Missense_Mutation_p.A128T|CCM2_uc003tmq.2_RNA|CCM2_uc003tmr.2_Intron|CCM2_uc011kcb.1_Missense_Mutation_p.A149T|CCM2_uc011kcc.1_Intron|CCM2_uc003tms.2_Missense_Mutation_p.A207T	NM_031443	NP_113631	Q9BSQ5	CCM2_HUMAN	cerebral cavernous malformation 2 isoform 2	186	PID.				endothelial tube morphogenesis|integrin-mediated signaling pathway|stress-activated MAPK cascade|vasculogenesis	cytoplasm	protein binding				0						GTCGGAGAGTGCAGTTGGGCC	0.612			NA							Familial_Cerebral_Cavernous_Angioma				4	91					0	0	0.000602	0	0
UPP1	7378	broad.mit.edu	37	7	48142902	48142902	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr7:48142902G>T	uc003toj.2	+	7	859	c.330G>T	c.(328-330)ATG>ATT	p.M110I	UPP1_uc003tok.2_Missense_Mutation_p.M110I|UPP1_uc003tol.2_Missense_Mutation_p.M110I|UPP1_uc011kcg.1_Missense_Mutation_p.M110I|UPP1_uc011kch.1_Intron|UPP1_uc003ton.2_Intron|UPP1_uc003too.2_Intron	NM_181597	NP_853628	Q16831	UPP1_HUMAN	uridine phosphorylase 1	110					nucleotide catabolic process|pyrimidine base metabolic process|pyrimidine nucleoside catabolic process|pyrimidine nucleoside salvage	cytosol	uridine phosphorylase activity				0						AGCATGGTATGGGCATTCCTT	0.453			NA											11	71					5.50884e-06	6.51169e-06	0.001368	1	0
ABCA13	154664	broad.mit.edu	37	7	48390351	48390351	+	Missense_Mutation	SNP	T	T	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr7:48390351T>A	uc003toq.2	+	30	10341	c.10316T>A	c.(10315-10317)CTG>CAG	p.L3439Q	ABCA13_uc010kys.1_Missense_Mutation_p.L513Q|ABCA13_uc003tos.1_Missense_Mutation_p.L265Q	NM_152701	NP_689914	Q86UQ4	ABCAD_HUMAN	ATP binding cassette, sub-family A (ABC1),	3439					transport	integral to membrane	ATP binding|ATPase activity			ovary(5)|central_nervous_system(4)|skin(1)	10						TTCCAGGCTCTGCAGTCTGTC	0.488			NA											22	93					0	0	0.002299	0	0
CROT	54677	broad.mit.edu	37	7	87022321	87022321	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr7:87022321G>T	uc003uit.2	+	17	1901	c.1656G>T	c.(1654-1656)CAG>CAT	p.Q552H	CROT_uc003uiu.2_Missense_Mutation_p.Q580H	NM_021151	NP_066974	Q9UKG9	OCTC_HUMAN	peroxisomal carnitine O-octanoyltransferase	552					fatty acid beta-oxidation using acyl-CoA oxidase|generation of precursor metabolites and energy|transport	peroxisomal matrix	carnitine O-octanoyltransferase activity			ovary(2)|lung(1)	3	Esophageal squamous(14;0.0058)|all_lung(186;0.201)|Lung NSC(181;0.203)				L-Carnitine(DB00583)	TACGAGTCCAGGGAGTGGTAG	0.418			NA											68	262					2.40655e-23	3.85374e-23	0.00361	1	0
ABCB4	5244	broad.mit.edu	37	7	87032462	87032462	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr7:87032462C>T	uc003uiv.1	-	27	3719	c.3643G>A	c.(3643-3645)GAA>AAA	p.E1215K	ABCB4_uc003uiw.1_Missense_Mutation_p.E1208K|ABCB4_uc003uix.1_Missense_Mutation_p.E1161K	NM_018849	NP_061337	P21439	MDR3_HUMAN	ATP-binding cassette, subfamily B, member 4	1215	ABC transporter 2.|Cytoplasmic (By similarity).				cellular lipid metabolic process	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus|membrane fraction	ATP binding|xenobiotic-transporting ATPase activity			ovary(4)|skin(1)|pancreas(1)	6	Esophageal squamous(14;0.0058)|all_lung(186;0.201)|Lung NSC(181;0.203)					TTTTCACTTTCAGTATCCAGA	0.428			NA											46	218					0	0	0.00361	0	0
ABCB1	5243	broad.mit.edu	37	7	87179872	87179872	+	Nonsense_Mutation	SNP	G	G	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr7:87179872G>T	uc003uiz.1	-	12	1554	c.1136C>A	c.(1135-1137)TCG>TAG	p.S379*	ABCB1_uc011khc.1_Nonsense_Mutation_p.S315*	NM_000927	NP_000918	P08183	MDR1_HUMAN	ATP-binding cassette, subfamily B, member 1	379	Cytoplasmic (Potential).				G2/M transition of mitotic cell cycle|stem cell proliferation	apical plasma membrane|cell surface|Golgi membrane|integral to membrane|intercellular canaliculus|membrane fraction	ATP binding|protein binding|xenobiotic-transporting ATPase activity			ovary(4)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	7	Esophageal squamous(14;0.00164)				Adenosine triphosphate(DB00171)|Alfentanil(DB00802)|Arsenic trioxide(DB01169)|Atazanavir(DB01072)|Carvedilol(DB01136)|Colchicine(DB01394)|Cyclosporine(DB00091)|Daunorubicin(DB00694)|Dipyridamole(DB00975)|Estramustine(DB01196)|Flupenthixol(DB00875)|Imatinib(DB00619)|Itraconazole(DB01167)|Nicardipine(DB00622)|Propafenone(DB01182)|Quinacrine(DB01103)|Quinidine(DB00908)|Ranolazine(DB00243)|Rifampin(DB01045)|Roxithromycin(DB00778)|Saquinavir(DB01232)|Tamoxifen(DB00675)|Vinblastine(DB00570)	CCCACTCTTCGAATAGCTGTC	0.333			NA											18	90					1.99824e-07	2.46017e-07	0.00499	1	0
ZNF804B	219578	broad.mit.edu	37	7	88962744	88962744	+	Missense_Mutation	SNP	A	A	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr7:88962744A>T	uc011khi.1	+	4	986	c.448A>T	c.(448-450)ATT>TTT	p.I150F		NM_181646	NP_857597	A4D1E1	Z804B_HUMAN	zinc finger protein 804B	150						intracellular	zinc ion binding			ovary(5)|skin(3)|pancreas(2)|upper_aerodigestive_tract(1)	11	all_hematologic(106;0.125)|Lung NSC(181;0.15)|all_lung(186;0.151)		STAD - Stomach adenocarcinoma(171;0.0513)			CCAGCAAGGAATTTTCCCCAT	0.393			NA								HNSCC(36;0.09)			18	52					0	0	0.007413	0	0
ZNF804B	219578	broad.mit.edu	37	7	88966056	88966056	+	Missense_Mutation	SNP	A	A	G			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr7:88966056A>G	uc011khi.1	+	4	4298	c.3760A>G	c.(3760-3762)ACC>GCC	p.T1254A		NM_181646	NP_857597	A4D1E1	Z804B_HUMAN	zinc finger protein 804B	1254						intracellular	zinc ion binding			ovary(5)|skin(3)|pancreas(2)|upper_aerodigestive_tract(1)	11	all_hematologic(106;0.125)|Lung NSC(181;0.15)|all_lung(186;0.151)		STAD - Stomach adenocarcinoma(171;0.0513)			TCTGACTCCAACCATTATCCC	0.478			NA								HNSCC(36;0.09)			8	211					0	0	0.001368	0	0
STEAP1	26872	broad.mit.edu	37	7	89790136	89790136	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr7:89790136G>C	uc003ujx.2	+	3	302	c.102G>C	c.(100-102)GAG>GAC	p.E34D	STEAP1_uc010lem.2_Missense_Mutation_p.E34D	NM_012449	NP_036581	Q9UHE8	STEA1_HUMAN	six transmembrane epithelial antigen of the	34					electron transport chain|ion transport|iron ion homeostasis	cell-cell junction|endosome membrane|integral to plasma membrane	channel activity|electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|oxidoreductase activity				0	all_hematologic(106;0.112)					ACACGGGAGAGACCAGCATGC	0.388			NA											19	154					0	0	0.010504	0	0
SAMD9	54809	broad.mit.edu	37	7	92733059	92733059	+	Silent	SNP	C	C	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr7:92733059C>A	uc003umf.2	-	3	2608	c.2352G>T	c.(2350-2352)GGG>GGT	p.G784G	SAMD9_uc003umg.2_Silent_p.G784G	NM_017654	NP_060124	Q5K651	SAMD9_HUMAN	sterile alpha motif domain containing 9	784						cytoplasm				ovary(3)|skin(2)|breast(1)|central_nervous_system(1)	7	all_cancers(62;5.71e-11)|all_epithelial(64;3.25e-10)|Breast(17;0.000675)|Lung NSC(181;0.0969)|all_lung(186;0.125)		STAD - Stomach adenocarcinoma(171;0.000302)			GGTTCATTGCCCCATAGGTGA	0.388			NA											37	168					2.52637e-11	3.52206e-11	0.005524	1	0
TRRAP	8295	broad.mit.edu	37	7	98574387	98574387	+	Silent	SNP	G	G	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr7:98574387G>T	uc003upp.2	+	54	8429	c.8220G>T	c.(8218-8220)CCG>CCT	p.P2740P	TRRAP_uc011kis.1_Silent_p.P2722P|TRRAP_uc003upr.2_Silent_p.P2439P	NM_003496	NP_003487	Q9Y4A5	TRRAP_HUMAN	transformation/transcription domain-associated	2740	FAT.				histone deubiquitination|histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|PCAF complex|STAGA complex|transcription factor TFTC complex	phosphotransferase activity, alcohol group as acceptor|protein binding|transcription cofactor activity			ovary(9)|large_intestine(8)|central_nervous_system(6)|skin(6)|stomach(5)|upper_aerodigestive_tract(1)|lung(1)|liver(1)	37	all_cancers(62;6.96e-09)|all_epithelial(64;4.86e-09)|Lung NSC(181;0.01)|all_lung(186;0.016)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)			TCACCCCGCCGCAGCAGGTGA	0.478			NA											10	84					1.58986e-06	1.91511e-06	0.008291	1	0
AZGP1	563	broad.mit.edu	37	7	99565973	99565973	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr7:99565973C>T	uc003ush.2	-	3	462	c.418G>A	c.(418-420)GAT>AAT	p.D140N		NM_001185	NP_001176	P25311	ZA2G_HUMAN	alpha-2-glycoprotein 1, zinc	140					antigen processing and presentation|cell adhesion|immune response|lipid catabolic process|negative regulation of cell proliferation	extracellular region|MHC class I protein complex	fatty acid binding|protein transmembrane transporter activity|ribonuclease activity			ovary(1)|central_nervous_system(1)	2	Esophageal squamous(72;0.0166)|Lung NSC(181;0.0211)|all_lung(186;0.0323)					TCCTTTCCATCATAGTAATAT	0.498			NA											8	474					0	0	0.004482	0	0
MUC17	140453	broad.mit.edu	37	7	100685732	100685733	+	Missense_Mutation	DNP	CC	CC	AA			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr7:100685732_100685733CC>AA	uc003uxp.1	+	3	11088_11089	c.11035_11036CC>AA	c.(11035-11037)CCT>AAT	p.P3679N	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	3679	Extracellular (Potential).|59.|59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					TCCTGTGACTCCTGAAGGTACC	0.52			NA											6	239					0	0	0.004672	0	0
SLC26A3	1811	broad.mit.edu	37	7	107431513	107431513	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr7:107431513C>A	uc003ver.2	-	5	761	c.550G>T	c.(550-552)GTG>TTG	p.V184L	SLC26A3_uc003ves.2_Missense_Mutation_p.V149L	NM_000111	NP_000102	P40879	S26A3_HUMAN	solute carrier family 26, member 3	184	Helical; (Potential).				excretion	integral to membrane|membrane fraction	inorganic anion exchanger activity|secondary active sulfate transmembrane transporter activity|sequence-specific DNA binding transcription factor activity|transcription cofactor activity			ovary(3)|skin(1)	4						CCAGAAAGCACTGTGACTGAT	0.488			NA											5	41					0.00116845	0.00127467	0.001168	1	0
PTPRZ1	5803	broad.mit.edu	37	7	121668644	121668644	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr7:121668644G>T	uc003vjy.2	+	14	5422	c.5027G>T	c.(5026-5028)AGT>ATT	p.S1676I	PTPRZ1_uc003vjz.2_Missense_Mutation_p.S816I|PTPRZ1_uc011knt.1_Missense_Mutation_p.S266I	NM_002851	NP_002842	P23471	PTPRZ_HUMAN	protein tyrosine phosphatase, receptor-type,	1676	Cytoplasmic (Potential).				central nervous system development	integral to plasma membrane	protein binding|protein tyrosine/threonine phosphatase activity|transmembrane receptor protein tyrosine phosphatase activity			ovary(3)|large_intestine(2)|lung(2)|central_nervous_system(1)|kidney(1)	9						TTAGAGGACAGTACATCCCCT	0.378			NA											39	112					1.07121e-22	1.69817e-22	0.006999	1	0
AASS	10157	broad.mit.edu	37	7	121738539	121738539	+	Silent	SNP	C	C	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr7:121738539C>T	uc003vka.2	-	14	1716	c.1620G>A	c.(1618-1620)CTG>CTA	p.L540L	AASS_uc011knu.1_RNA|AASS_uc011knv.1_RNA|AASS_uc003vkb.2_Silent_p.L540L|AASS_uc011knw.1_Silent_p.L28L	NM_005763	NP_005754	Q9UDR5	AASS_HUMAN	aminoadipate-semialdehyde synthase precursor	540	Saccharopine dehydrogenase.				protein tetramerization	mitochondrial matrix	binding|saccharopine dehydrogenase (NAD+, L-glutamate-forming) activity|saccharopine dehydrogenase (NADP+, L-lysine-forming) activity			upper_aerodigestive_tract(1)|ovary(1)	2					L-Glutamic Acid(DB00142)|NADH(DB00157)	CCAAGAAGCCCAGCTTCTCTT	0.338			NA											6	72					0	0	0.001984	0	0
WASL	8976	broad.mit.edu	37	7	123346396	123346396	+	Missense_Mutation	SNP	T	T	C			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr7:123346396T>C	uc003vkz.2	-	4	699	c.371A>G	c.(370-372)GAA>GGA	p.E124G		NM_003941	NP_003932	O00401	WASL_HUMAN	Wiskott-Aldrich syndrome gene-like protein	124	WH1.				actin polymerization or depolymerization|axon guidance|cellular component movement|nitric oxide metabolic process|protein complex assembly|regulation of nitric-oxide synthase activity|regulation of transcription, DNA-dependent|transcription, DNA-dependent	actin cytoskeleton|cytosol|nucleolus|plasma membrane	actin binding|small GTPase regulator activity				0						TGCTTCTTCTTCATTGGCAAA	0.303			NA											6	38					0	0	0.001984	0	0
SPAM1	6677	broad.mit.edu	37	7	123594227	123594227	+	Silent	SNP	A	A	G			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr7:123594227A>G	uc003vld.2	+	4	1005	c.603A>G	c.(601-603)GTA>GTG	p.V201V	SPAM1_uc003vle.2_Silent_p.V201V|SPAM1_uc011koa.1_5'Flank|SPAM1_uc003vlf.3_Silent_p.V201V|SPAM1_uc010lku.2_Silent_p.V201V	NM_153189	NP_694859	P38567	HYALP_HUMAN	sperm adhesion molecule 1 isoform 2	201					binding of sperm to zona pellucida|carbohydrate metabolic process|cell adhesion|fusion of sperm to egg plasma membrane	anchored to membrane|plasma membrane	hyalurononglucosaminidase activity			ovary(3)|kidney(1)	4					Hyaluronidase(DB00070)	ATTTCCTGGTAGAGACTATAA	0.383			NA											14	103					0	0	0.00245	0	0
GCC1	79571	broad.mit.edu	37	7	127225205	127225205	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr7:127225205C>T	uc003vma.2	-	1	450	c.32G>A	c.(31-33)GGC>GAC	p.G11D		NM_024523	NP_078799	Q96CN9	GCC1_HUMAN	Golgi coiled-coil protein 1	11						Golgi membrane|plasma membrane	protein binding			ovary(2)	2						CTTGCTCGGGCCGCCCCCGAA	0.572			NA									OREG0003808	type=REGULATORY REGION|Gene=GCC1|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	14	115					0	0	0.004007	0	0
FSCN3	29999	broad.mit.edu	37	7	127236391	127236391	+	Missense_Mutation	SNP	T	T	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr7:127236391T>A	uc003vmd.1	+	3	1070	c.851T>A	c.(850-852)GTG>GAG	p.V284E	FSCN3_uc011koh.1_Missense_Mutation_p.V150E|FSCN3_uc010llc.1_Missense_Mutation_p.V284E	NM_020369	NP_065102	Q9NQT6	FSCN3_HUMAN	fascin 3	284						actin cytoskeleton|cytoplasm	actin filament binding|protein binding, bridging			ovary(1)	1						GATGGTGAGGTGCGTGCTGCT	0.552			NA											32	235					0	0	0.009535	0	0
PLXNA4	91584	broad.mit.edu	37	7	131908336	131908336	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr7:131908336G>A	uc003vra.3	-	9	2276	c.2047C>T	c.(2047-2049)CAT>TAT	p.H683Y		NM_020911	NP_065962	Q9HCM2	PLXA4_HUMAN	plexin A4 isoform 1	683	PSI 2.|Extracellular (Potential).					integral to membrane|intracellular|plasma membrane				ovary(1)	1						TTGGGGTCATGGGTGCAGACA	0.592			NA											4	36					0	0	0.001168	0	0
PLXNA4	91584	broad.mit.edu	37	7	132174174	132174174	+	Silent	SNP	G	G	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr7:132174174G>T	uc003vra.3	-	3	1477	c.1248C>A	c.(1246-1248)TCC>TCA	p.S416S	PLXNA4_uc003vrc.2_Silent_p.S416S|PLXNA4_uc003vrb.2_Silent_p.S416S	NM_020911	NP_065962	Q9HCM2	PLXA4_HUMAN	plexin A4 isoform 1	416	Extracellular (Potential).|Sema.					integral to membrane|intracellular|plasma membrane				ovary(1)	1						GCACCATGTCGGACACTCCCA	0.493			NA											15	31					4.7546e-09	6.20849e-09	0.004007	1	0
AKR1B15	441282	broad.mit.edu	37	7	134252977	134252977	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr7:134252977G>C	uc011kpr.1	+	4	517	c.218G>C	c.(217-219)TGT>TCT	p.C73S	AKR1B15_uc003vrt.2_Missense_Mutation_p.C45S|AKR1B15_uc011kps.1_Missense_Mutation_p.C45S	NM_001080538	NP_001074007	C9JRZ8	AK1BF_HUMAN	aldo-keto reductase family 1, member B15	73							oxidoreductase activity			ovary(1)	1						CACATTGACTGTGCCTATTTC	0.473			NA											11	116					0	0	0.000978	0	0
TBXAS1	6916	broad.mit.edu	37	7	139655295	139655295	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr7:139655295G>C	uc011kqv.1	+	8	882	c.718G>C	c.(718-720)GTC>CTC	p.V240L	TBXAS1_uc003vvh.2_Missense_Mutation_p.V194L|TBXAS1_uc010lne.2_Missense_Mutation_p.V126L|TBXAS1_uc011kqu.1_Missense_Mutation_p.V145L|TBXAS1_uc003vvi.2_Missense_Mutation_p.V194L|TBXAS1_uc003vvj.2_Missense_Mutation_p.V194L|TBXAS1_uc011kqw.1_Missense_Mutation_p.V174L	NM_001130966	NP_001124438	P24557	THAS_HUMAN	thromboxane A synthase 1, platelet isoform	193	Cytoplasmic (Potential).				hormone biosynthetic process|prostaglandin biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum lumen|endoplasmic reticulum membrane|integral to membrane	electron carrier activity|heme binding|monooxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen|thromboxane-A synthase activity			ovary(2)|breast(1)	3	Melanoma(164;0.0142)					GGTTGCCAGCGTCGCCTTTGG	0.572			NA											29	133					0	0	0.003271	0	0
MKRN1	23608	broad.mit.edu	37	7	140154936	140154936	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr7:140154936C>G	uc003vvt.2	-	7	1420	c.1195G>C	c.(1195-1197)GAG>CAG	p.E399Q	MKRN1_uc003vvs.2_Missense_Mutation_p.E335Q|MKRN1_uc011krd.1_Missense_Mutation_p.E133Q	NM_013446	NP_038474	Q9UHC7	MKRN1_HUMAN	makorin ring finger protein 1 isoform 1	399							ligase activity|nucleic acid binding|protein binding|zinc ion binding			ovary(1)	1	Melanoma(164;0.00956)					CTCTGTGGCTCCTCTCTACGG	0.488			NA											19	162					0	0	0.003271	0	0
OR9A4	130075	broad.mit.edu	37	7	141619029	141619029	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr7:141619029G>T	uc003vwu.1	+	1	354	c.354G>T	c.(352-354)ATG>ATT	p.M118I		NM_001001656	NP_001001656	Q8NGU2	OR9A4_HUMAN	olfactory receptor, family 9, subfamily A,	118	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	Melanoma(164;0.0171)					TTGGAGCAATGGCTGTGGACC	0.478			NA											83	152					2.13431e-38	3.5311e-38	0.00361	1	0
EPHA1	2041	broad.mit.edu	37	7	143096454	143096454	+	Silent	SNP	C	C	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr7:143096454C>T	uc003wcz.2	-	5	975	c.888G>A	c.(886-888)ACG>ACA	p.T296T		NM_005232	NP_005223	P21709	EPHA1_HUMAN	ephrin receptor EphA1 precursor	296	Extracellular (Potential).|Cys-rich.					integral to plasma membrane	ATP binding|ephrin receptor activity			ovary(3)|lung(1)|breast(1)	5	Melanoma(164;0.205)	Myeloproliferative disorder(862;0.0255)				GCTGGGGGCACGTGAGACAAT	0.602			NA											6	58					0	0	0.001984	0	0
OR2A5	393046	broad.mit.edu	37	7	143747932	143747932	+	Silent	SNP	C	C	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr7:143747932C>T	uc011ktw.1	+	1	438	c.438C>T	c.(436-438)GTC>GTT	p.V146V		NM_012365	NP_036497	Q96R48	OR2A5_HUMAN	olfactory receptor, family 2, subfamily A,	146	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(3)	3	Melanoma(164;0.0783)					TCCTGGCTGTCACTTCTTGGG	0.522			NA											13	307					0	0	0.001855	0	0
WDR60	55112	broad.mit.edu	37	7	158683963	158683963	+	Missense_Mutation	SNP	A	A	G			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr7:158683963A>G	uc003woe.3	+	8	1156	c.998A>G	c.(997-999)CAC>CGC	p.H333R	WDR60_uc010lqv.2_RNA|WDR60_uc010lqw.2_5'UTR	NM_018051	NP_060521	Q8WVS4	WDR60_HUMAN	WD repeat domain 60	333										ovary(2)|breast(1)|central_nervous_system(1)	4	Ovarian(565;0.152)	all_cancers(7;1.25e-09)|all_epithelial(9;0.000894)|all_hematologic(28;0.00603)	OV - Ovarian serous cystadenocarcinoma(82;0.00174)	UCEC - Uterine corpus endometrioid carcinoma (81;0.19)|STAD - Stomach adenocarcinoma(7;0.18)		TAGCATGGCCACGAGGAAGGC	0.607			NA											69	144					0	0	0.00361	0	0
ARHGEF10	9639	broad.mit.edu	37	8	1857512	1857512	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr8:1857512G>T	uc003wpr.2	+	18	2197	c.2019G>T	c.(2017-2019)TGG>TGT	p.W673C	ARHGEF10_uc003wpq.1_Missense_Mutation_p.W697C|ARHGEF10_uc003wps.2_Missense_Mutation_p.W635C|ARHGEF10_uc003wpv.2_Missense_Mutation_p.W406C|ARHGEF10_uc010lre.2_Missense_Mutation_p.W353C	NM_014629	NP_055444	O15013	ARHGA_HUMAN	Rho guanine nucleotide exchange factor 10	698					centrosome duplication|myelination in peripheral nervous system|positive regulation of GTP catabolic process|positive regulation of stress fiber assembly|regulation of Rho protein signal transduction|spindle assembly involved in mitosis	centrosome|cytosol|soluble fraction	kinesin binding|Rho guanyl-nucleotide exchange factor activity			large_intestine(1)	1		Colorectal(14;3.46e-05)|Renal(68;0.000518)|Ovarian(12;0.00409)|Myeloproliferative disorder(644;0.0255)|Hepatocellular(245;0.0834)		COAD - Colon adenocarcinoma(149;1.62e-05)|BRCA - Breast invasive adenocarcinoma(11;1.68e-05)|KIRC - Kidney renal clear cell carcinoma(542;0.00361)|READ - Rectum adenocarcinoma(644;0.0718)		TGCTGAAGTGGAGCGTTCCAC	0.567			NA											36	182					1.90571e-15	2.83168e-15	0.004289	1	0
CSMD1	64478	broad.mit.edu	37	8	2820078	2820078	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr8:2820078G>T	uc011kwk.1	-	61	9931	c.9541C>A	c.(9541-9543)CAG>AAG	p.Q3181K	CSMD1_uc011kwj.1_Missense_Mutation_p.Q2510K|CSMD1_uc010lrg.2_Missense_Mutation_p.Q1072K	NM_033225	NP_150094	Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1 precursor	3181	Extracellular (Potential).|Sushi 26.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		GATTTGCACTGGAAGAAGACT	0.502			NA											12	57					2.68362e-12	3.79146e-12	0.001368	1	0
CSMD1	64478	broad.mit.edu	37	8	2857502	2857502	+	Silent	SNP	A	A	G			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr8:2857502A>G	uc011kwk.1	-	53	8574	c.8184T>C	c.(8182-8184)TCT>TCC	p.S2728S	CSMD1_uc011kwj.1_Silent_p.S2057S|CSMD1_uc010lrg.2_Silent_p.S738S	NM_033225	NP_150094	Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1 precursor	2728	Extracellular (Potential).|Sushi 18.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		GCGTTTGTCCAGACCACTTGT	0.473			NA											8	277					0	0	0.006214	0	0
CSMD1	64478	broad.mit.edu	37	8	2965290	2965290	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr8:2965290G>T	uc011kwk.1	-	45	7178	c.6788C>A	c.(6787-6789)CCA>CAA	p.P2263Q	CSMD1_uc011kwj.1_Missense_Mutation_p.P1655Q|CSMD1_uc010lrg.2_Missense_Mutation_p.P331Q	NM_033225	NP_150094	Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1 precursor	2263	Extracellular (Potential).|Sushi 13.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		TGGAACCGCTGGGGGAGGTTG	0.333			NA											13	165					9.31168e-06	1.09522e-05	0.001855	1	0
CSMD1	64478	broad.mit.edu	37	8	3008972	3008972	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr8:3008972G>T	uc011kwk.1	-	40	6371	c.5981C>A	c.(5980-5982)TCT>TAT	p.S1994Y	CSMD1_uc011kwj.1_Missense_Mutation_p.S1386Y|CSMD1_uc003wqe.2_Missense_Mutation_p.S1150Y|CSMD1_uc010lrg.2_Missense_Mutation_p.S62Y	NM_033225	NP_150094	Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1 precursor	1994	Extracellular (Potential).|CUB 12.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		GTTGGGGTAAGAACCTGGGAA	0.488			NA											9	40					2.17888e-05	2.53445e-05	0.006214	1	0
CSMD1	64478	broad.mit.edu	37	8	3205575	3205575	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr8:3205575G>T	uc011kwk.1	-	22	3806	c.3416C>A	c.(3415-3417)GCC>GAC	p.A1139D	CSMD1_uc011kwj.1_Missense_Mutation_p.A531D|CSMD1_uc003wqe.2_Missense_Mutation_p.A295D	NM_033225	NP_150094	Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1 precursor	1139	Extracellular (Potential).|CUB 7.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		GCCCTTGCCGGCTTCTGTTTC	0.383			NA											3	22					0.004672	0.00496531	0.004672	1	0
CSMD1	64478	broad.mit.edu	37	8	3253859	3253859	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr8:3253859C>A	uc011kwk.1	-	17	2843	c.2453G>T	c.(2452-2454)GGG>GTG	p.G818V	CSMD1_uc011kwj.1_Missense_Mutation_p.G210V|CSMD1_uc003wqe.2_5'UTR	NM_033225	NP_150094	Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1 precursor	818	Extracellular (Potential).|CUB 5.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		ACTGGCTGGCCCATCTCTGAC	0.522			NA											4	18					0.00024832	0.000278259	0.009096	1	0
CSMD1	64478	broad.mit.edu	37	8	3265427	3265427	+	Missense_Mutation	SNP	A	A	C			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr8:3265427A>C	uc011kwk.1	-	14	2458	c.2068T>G	c.(2068-2070)TAC>GAC	p.Y690D	CSMD1_uc011kwj.1_Missense_Mutation_p.Y82D	NM_033225	NP_150094	Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1 precursor	690	Extracellular (Potential).|CUB 4.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		TTACTGGTGTAAGTGATGTTG	0.443			NA											3	20					0	0	0.004672	0	0
SGCZ	137868	broad.mit.edu	37	8	14181709	14181710	+	Missense_Mutation	DNP	CC	CC	AA			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr8:14181709_14181710CC>AA	uc003wwq.2	-	3	898_899	c.238_239GG>TT	c.(238-240)GGT>TTT	p.G80F	SGCZ_uc010lss.2_Intron	NM_139167	NP_631906	Q96LD1	SGCZ_HUMAN	sarcoglycan zeta	67	Extracellular (Potential).				cytoskeleton organization	cytoplasm|cytoskeleton|integral to membrane|sarcolemma				ovary(2)|central_nervous_system(1)	3				all cancers(2;0.000643)|Colorectal(111;0.00674)|COAD - Colon adenocarcinoma(73;0.0193)|GBM - Glioblastoma multiforme(2;0.026)		ATTTCCCATACCATCCTACAAG	0.361			NA											6	84					0	0	0.004672	0	0
SORBS3	10174	broad.mit.edu	37	8	22414373	22414373	+	Silent	SNP	G	G	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr8:22414373G>A	uc003xbv.2	+	4	706	c.366G>A	c.(364-366)GAG>GAA	p.E122E	SORBS3_uc011kzk.1_RNA	NM_005775	NP_005766	O60504	VINEX_HUMAN	sorbin and SH3 domain containing 3 isoform 1	122	SoHo.				muscle contraction|positive regulation of stress fiber assembly	cytoskeleton|cytosol|nucleus	protein binding|structural constituent of cytoskeleton|vinculin binding				0		Prostate(55;0.0421)|Breast(100;0.102)		BRCA - Breast invasive adenocarcinoma(99;0.00566)|Colorectal(74;0.0146)|COAD - Colon adenocarcinoma(73;0.061)		TCAAGTACGAGGGAATCGGGC	0.652			NA											6	72					0	0	0.006214	0	0
SCARA3	51435	broad.mit.edu	37	8	27517030	27517030	+	Missense_Mutation	SNP	T	T	C			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr8:27517030T>C	uc003xga.1	+	5	1484	c.1343T>C	c.(1342-1344)ATC>ACC	p.I448T	SCARA3_uc003xgb.1_Missense_Mutation_p.I448T	NM_016240	NP_057324	Q6AZY7	SCAR3_HUMAN	scavenger receptor class A, member 3 isoform 1	448	Extracellular (Potential).				response to oxidative stress|UV protection	collagen|endoplasmic reticulum membrane|Golgi membrane|integral to membrane	scavenger receptor activity			skin(2)|ovary(1)|breast(1)	4		Ovarian(32;2.61e-05)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0219)|Colorectal(74;0.148)		CATGGAGAAATCCTTCGCAAT	0.557			NA											8	18					0	0	0.006214	0	0
C8orf80	389643	broad.mit.edu	37	8	27898648	27898648	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr8:27898648C>T	uc003xgm.3	-	13	1674	c.1531G>A	c.(1531-1533)GCC>ACC	p.A511T		NM_001010906	NP_001010906	Q68CJ6	SLIP_HUMAN	speckled-like pattern in the germinal center	511						nucleus	GTP binding|GTPase activity			ovary(1)|central_nervous_system(1)	2		Ovarian(32;0.0218)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0228)|KIRC - Kidney renal clear cell carcinoma(542;0.126)|Kidney(114;0.15)|Colorectal(74;0.181)		TCCATGCAGGCGAAGCACTGT	0.567			NA											3	7					0	0	0.004672	0	0
TEX15	56154	broad.mit.edu	37	8	30695247	30695247	+	Silent	SNP	T	T	C			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr8:30695247T>C	uc003xil.2	-	3	7404	c.7404A>G	c.(7402-7404)ACA>ACG	p.T2468T		NM_031271	NP_112561	Q9BXT5	TEX15_HUMAN	testis expressed 15	2468										ovary(3)|upper_aerodigestive_tract(2)|skin(2)	7				KIRC - Kidney renal clear cell carcinoma(542;0.0918)|Kidney(114;0.111)		CTGGTGAAAATGTGCCATGTA	0.383			NA											16	347					0	0	0.003163	0	0
UNC5D	137970	broad.mit.edu	37	8	35583678	35583678	+	Silent	SNP	C	C	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr8:35583678C>T	uc003xjr.1	+	10	1640	c.1312C>T	c.(1312-1314)CTG>TTG	p.L438L	UNC5D_uc003xjs.1_Silent_p.L433L|UNC5D_uc003xju.1_Silent_p.L14L|UNC5D_uc003xjt.1_Silent_p.L196L	NM_080872	NP_543148	Q6UXZ4	UNC5D_HUMAN	unc-5 homolog D precursor	438	Cytoplasmic (Potential).				apoptosis|axon guidance	integral to membrane	receptor activity			upper_aerodigestive_tract(2)|ovary(2)|pancreas(1)|skin(1)	6				READ - Rectum adenocarcinoma(1;1.31e-05)|Colorectal(1;0.000723)		AGGTAACTCCCTGCTCCTGAA	0.507			NA											21	99					0	0	0.00278	0	0
PLAT	5327	broad.mit.edu	37	8	42044933	42044933	+	Silent	SNP	C	C	T	rs115361478	byFrequency	TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr8:42044933C>T	uc003xos.2	-	6	731	c.522G>A	c.(520-522)GGG>GGA	p.G174G	PLAT_uc010lxf.1_Silent_p.G91G|PLAT_uc010lxg.1_Intron|PLAT_uc003xot.2_Silent_p.G128G|PLAT_uc011lcm.1_Intron|PLAT_uc011lcn.1_Intron	NM_000930	NP_000921	P00750	TPA_HUMAN	plasminogen activator, tissue isoform 1	174	Kringle 1.				blood coagulation|fibrinolysis|negative regulation of proteolysis|protein modification process|proteolysis	cell surface|cytoplasm|extracellular space	protein binding|serine-type endopeptidase activity			breast(1)|skin(1)	2	all_cancers(6;3.84e-26)|all_epithelial(6;9.61e-28)|all_lung(13;7.2e-13)|Lung NSC(13;1.18e-11)|Ovarian(28;0.00438)|Prostate(17;0.0119)|Colorectal(14;0.0468)|Lung SC(25;0.211)	all_lung(54;0.000378)|Lung NSC(58;0.00145)|Hepatocellular(245;0.0524)|Renal(179;0.0822)|Esophageal squamous(32;0.0954)	BRCA - Breast invasive adenocarcinoma(8;5.23e-10)|OV - Ovarian serous cystadenocarcinoma(14;0.00135)|Colorectal(10;0.00165)|Lung(22;0.00467)|COAD - Colon adenocarcinoma(11;0.0171)|LUSC - Lung squamous cell carcinoma(45;0.024)		Alteplase(DB00009)|Aminocaproic Acid(DB00513)|Anistreplase(DB00029)|Iloprost(DB01088)|Reteplase(DB00015)|Tenecteplase(DB00031)|Tranexamic Acid(DB00302)|Urokinase(DB00013)	AGTTGTGGTTCCCCAGGCCCA	0.572			NA											5	33					0	0	0.00308	0	0
PLAT	5327	broad.mit.edu	37	8	42046539	42046539	+	Missense_Mutation	SNP	A	A	G			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr8:42046539A>G	uc003xos.2	-	4	375	c.166T>C	c.(166-168)TGG>CGG	p.W56R	PLAT_uc010lxf.1_Intron|PLAT_uc010lxg.1_Missense_Mutation_p.W56R|PLAT_uc003xot.2_Intron|PLAT_uc011lcm.1_Missense_Mutation_p.W56R|PLAT_uc011lcn.1_Missense_Mutation_p.W56R	NM_000930	NP_000921	P00750	TPA_HUMAN	plasminogen activator, tissue isoform 1	56	Fibronectin type-I.				blood coagulation|fibrinolysis|negative regulation of proteolysis|protein modification process|proteolysis	cell surface|cytoplasm|extracellular space	protein binding|serine-type endopeptidase activity			breast(1)|skin(1)	2	all_cancers(6;3.84e-26)|all_epithelial(6;9.61e-28)|all_lung(13;7.2e-13)|Lung NSC(13;1.18e-11)|Ovarian(28;0.00438)|Prostate(17;0.0119)|Colorectal(14;0.0468)|Lung SC(25;0.211)	all_lung(54;0.000378)|Lung NSC(58;0.00145)|Hepatocellular(245;0.0524)|Renal(179;0.0822)|Esophageal squamous(32;0.0954)	BRCA - Breast invasive adenocarcinoma(8;5.23e-10)|OV - Ovarian serous cystadenocarcinoma(14;0.00135)|Colorectal(10;0.00165)|Lung(22;0.00467)|COAD - Colon adenocarcinoma(11;0.0171)|LUSC - Lung squamous cell carcinoma(45;0.024)		Alteplase(DB00009)|Aminocaproic Acid(DB00513)|Anistreplase(DB00029)|Iloprost(DB01088)|Reteplase(DB00015)|Tenecteplase(DB00031)|Tranexamic Acid(DB00302)|Urokinase(DB00013)	GGGCGCAGCCATGACTGATGT	0.473			NA											7	309					0	0	0.006214	0	0
RNF170	81790	broad.mit.edu	37	8	42725241	42725241	+	Silent	SNP	G	G	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr8:42725241G>A	uc003xpo.2	-	4	705	c.228C>T	c.(226-228)GCC>GCT	p.A76A	RNF170_uc011lcx.1_Silent_p.A76A|RNF170_uc010lxp.2_5'UTR|RNF170_uc003xpm.2_Silent_p.A76A|RNF170_uc003xpp.2_Missense_Mutation_p.P5L|RNF170_uc003xpn.2_Missense_Mutation_p.P5L|RNF170_uc003xpq.3_Silent_p.A76A	NM_001160223	NP_001153695	Q96K19	RN170_HUMAN	ring finger protein 170 isoform a	76						integral to membrane	zinc ion binding				0	all_lung(13;1.25e-11)|Lung NSC(13;3.55e-10)|Ovarian(28;0.01)|Prostate(17;0.0119)|Lung SC(25;0.184)	all_lung(54;0.00645)|Lung NSC(58;0.0176)|Esophageal squamous(32;0.131)|Hepatocellular(245;0.133)|Renal(179;0.151)	Lung(22;0.048)|LUSC - Lung squamous cell carcinoma(45;0.114)			GCTGTCGAGTGGCAGCAGGTG	0.473			NA											6	43					0	0	0.001984	0	0
SNTG1	54212	broad.mit.edu	37	8	51621445	51621445	+	Splice_Site	SNP	G	G	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr8:51621445G>T	uc010lxy.1	+	18	1563	c.1192_splice	c.e18-1	p.C398_splice	SNTG1_uc003xqs.1_Splice_Site_p.C398_splice|SNTG1_uc010lxz.1_Splice_Site_p.C398_splice|SNTG1_uc011ldl.1_Splice_Site	NM_018967	NP_061840	Q9NSN8	SNTG1_HUMAN	syntrophin, gamma 1						cell communication	cytoplasm|cytoskeleton|nucleus|ruffle membrane|syntrophin complex	actin binding|protein C-terminus binding			ovary(5)	5		all_cancers(86;0.00754)|all_epithelial(80;9.76e-05)|Lung NSC(129;0.000865)|all_lung(136;0.00249)|Colorectal(162;0.22)				GTTCTACCTAGTGCAAGACCT	0.279			NA											39	87					3.33393e-15	4.93069e-15	0.004878	1	0
PXDNL	137902	broad.mit.edu	37	8	52321066	52321066	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr8:52321066C>A	uc003xqu.3	-	17	3219	c.3118G>T	c.(3118-3120)GTG>TTG	p.V1040L	PXDNL_uc003xqt.3_RNA	NM_144651	NP_653252	A1KZ92	PXDNL_HUMAN	peroxidasin homolog-like precursor	1040					hydrogen peroxide catabolic process	extracellular space	heme binding|peroxidase activity			ovary(1)|pancreas(1)	2		all_cancers(86;0.107)|Lung NSC(129;0.00641)|all_epithelial(80;0.00716)|all_lung(136;0.015)				CCTGCATTCACGTTGGGGTTG	0.522			NA											4	42					0.000602214	0.000665384	0.000602	1	0
ST18	9705	broad.mit.edu	37	8	53084677	53084677	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr8:53084677G>C	uc003xqz.2	-	5	900	c.744C>G	c.(742-744)AAC>AAG	p.N248K	ST18_uc011ldq.1_5'UTR|ST18_uc011ldr.1_Missense_Mutation_p.N213K|ST18_uc011lds.1_Missense_Mutation_p.N153K|ST18_uc003xra.2_Missense_Mutation_p.N248K|ST18_uc003xrb.2_Missense_Mutation_p.N248K	NM_014682	NP_055497	O60284	ST18_HUMAN	suppression of tumorigenicity 18	248						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)|skin(1)	5		Lung NSC(129;0.131)|all_epithelial(80;0.217)|all_lung(136;0.229)				AATCACACCTGTTCTCACAAG	0.443			NA											29	144					0	0	0.009535	0	0
PTTG3P	26255	broad.mit.edu	37	8	67679693	67679693	+	Nonsense_Mutation	SNP	A	A	C			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr8:67679693A>C	uc011leu.1	-	1	548	c.548T>G	c.(547-549)TTA>TGA	p.L183*	SGK3_uc003xwp.2_Intron|SGK3_uc003xwr.2_Intron	NR_002734				RecName: Full=Securin-3; AltName: Full=Pituitary tumor transforming gene 3 protein;          Short=hPTTG3; AltName: Full=rcPTTG1;												0						CAGAATGCTTAAAGGAGACTG	0.418			NA											60	146					0	0	0.00361	0	0
ZFHX4	79776	broad.mit.edu	37	8	77765002	77765002	+	Nonsense_Mutation	SNP	G	G	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr8:77765002G>T	uc003yav.2	+	10	6097	c.5710G>T	c.(5710-5712)GGA>TGA	p.G1904*	ZFHX4_uc003yau.1_Nonsense_Mutation_p.G1949*|ZFHX4_uc003yaw.1_Nonsense_Mutation_p.G1904*	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	1904	C2H2-type 14.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			ACTAGAATGTGGAACATGTGG	0.378			NA								HNSCC(33;0.089)			25	85					2.21704e-12	3.14633e-12	0.00278	1	0
ZFHX4	79776	broad.mit.edu	37	8	77768314	77768314	+	Missense_Mutation	SNP	A	A	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr8:77768314A>T	uc003yav.2	+	10	9409	c.9022A>T	c.(9022-9024)ACC>TCC	p.T3008S	ZFHX4_uc003yau.1_Missense_Mutation_p.T3053S|ZFHX4_uc003yaw.1_Missense_Mutation_p.T3008S	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	3008						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			CTTGGCTCCGACCACGGTTCG	0.507			NA								HNSCC(33;0.089)			53	86					0	0	0.00361	0	0
ZFHX4	79776	broad.mit.edu	37	8	77768330	77768330	+	Missense_Mutation	SNP	T	T	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr8:77768330T>A	uc003yav.2	+	10	9425	c.9038T>A	c.(9037-9039)CTG>CAG	p.L3013Q	ZFHX4_uc003yau.1_Missense_Mutation_p.L3058Q|ZFHX4_uc003yaw.1_Missense_Mutation_p.L3013Q	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	3013						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			GTTCGGCAGCTGATGGCACAG	0.522			NA								HNSCC(33;0.089)			5	140					0	0	0.001168	0	0
CA1	759	broad.mit.edu	37	8	86240888	86240888	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr8:86240888G>T	uc003ydh.2	-	9	887	c.687C>A	c.(685-687)AGC>AGA	p.S229R	CA13_uc003ydf.1_Intron|CA1_uc010mae.1_Missense_Mutation_p.S229R|CA1_uc003ydi.2_Missense_Mutation_p.S229R	NM_001738	NP_001729	P00915	CAH1_HUMAN	carbonic anhydrase I	229					one-carbon metabolic process	Golgi apparatus	carbonate dehydratase activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2		all_lung(136;4.89e-06)			Acetazolamide(DB00819)|Amlodipine(DB00381)|Bendroflumethiazide(DB00436)|Benzthiazide(DB00562)|Brinzolamide(DB01194)|Chlorothiazide(DB00880)|Cyclothiazide(DB00606)|Diazoxide(DB01119)|Dichlorphenamide(DB01144)|Ethinamate(DB01031)|Ethoxzolamide(DB00311)|Hydrochlorothiazide(DB00999)|Hydroflumethiazide(DB00774)|Levetiracetam(DB01202)|Methazolamide(DB00703)|Methyclothiazide(DB00232)|Quinethazone(DB01325)|Trichlormethiazide(DB01021)|Verapamil(DB00661)|Zonisamide(DB00909)	TTGATAGAAGGCTGCGGAATT	0.383			NA											18	113					5.3912e-06	6.39657e-06	0.006122	1	0
Unknown	0	broad.mit.edu	37	8	86567347	86567347	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr8:86567347G>T	uc003ydl.1	-	1	559	c.472C>A	c.(472-474)CTG>ATG	p.L158M		NM_172239	NP_758439			exonuclease GOR												NA						GTCAGCTCCAGGCCATGCGTG	0.567			NA											8	118					0.000274275	0.000305179	0.004482	1	0
MMP16	4325	broad.mit.edu	37	8	89053712	89053712	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr8:89053712G>A	uc003yeb.3	-	10	2083	c.1801C>T	c.(1801-1803)CGC>TGC	p.R601C		NM_005941	NP_005932	P51512	MMP16_HUMAN	matrix metalloproteinase 16 isoform 1	601	Cytoplasmic (Potential).				collagen catabolic process|proteolysis	cell surface|integral to plasma membrane|proteinaceous extracellular matrix	calcium ion binding|enzyme activator activity|metalloendopeptidase activity|zinc ion binding			upper_aerodigestive_tract(2)|ovary(2)|central_nervous_system(1)|urinary_tract(1)|skin(1)|kidney(1)	8						TGCATAGAGCGTTTACAGTAC	0.438			NA											46	97					0	0	0.00361	0	0
MATN2	4147	broad.mit.edu	37	8	98973692	98973692	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr8:98973692C>T	uc003yic.2	+	5	1123	c.892C>T	c.(892-894)CCG>TCG	p.P298S	MATN2_uc003yib.1_Missense_Mutation_p.P298S|MATN2_uc010mbh.1_Missense_Mutation_p.P298S|MATN2_uc003yid.2_Missense_Mutation_p.P298S|MATN2_uc003yie.1_Missense_Mutation_p.P298S|MATN2_uc010mbi.1_Intron	NM_002380	NP_002371	O00339	MATN2_HUMAN	matrilin 2 isoform a precursor	298	EGF-like 2.					proteinaceous extracellular matrix	calcium ion binding			ovary(2)	2	Breast(36;1.43e-06)		OV - Ovarian serous cystadenocarcinoma(57;0.244)			TGTGAATGTGCCGGGCTCCTT	0.572			NA											26	63					0	0	0.002096	0	0
VPS13B	157680	broad.mit.edu	37	8	100832227	100832227	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr8:100832227G>T	uc003yiv.2	+	49	9057	c.8946G>T	c.(8944-8946)TTG>TTT	p.L2982F	VPS13B_uc003yiw.2_Missense_Mutation_p.L2957F	NM_017890	NP_060360	Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13B isoform 5	2982					protein transport					ovary(7)|skin(4)|lung(3)|central_nervous_system(2)|pancreas(2)|breast(1)|kidney(1)	20	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			GAACTTTGTTGATAGAACTTC	0.443	Colon(161;2205 2542 7338 31318)		NA											19	153					2.39187e-15	3.54296e-15	0.008871	1	0
DPYS	1807	broad.mit.edu	37	8	105456612	105456612	+	Silent	SNP	C	C	G			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr8:105456612C>G	uc003yly.3	-	4	786	c.657G>C	c.(655-657)CTG>CTC	p.L219L		NM_001385	NP_001376	Q14117	DPYS_HUMAN	dihydropyrimidinase	219					protein homotetramerization|pyrimidine nucleoside catabolic process|thymine catabolic process|uracil catabolic process	cytosol	dihydropyrimidinase activity|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)	2			OV - Ovarian serous cystadenocarcinoma(57;1.61e-06)|STAD - Stomach adenocarcinoma(118;0.229)			CTGGGCGGCACAGCTCGTGGC	0.532			NA											7	47					0	0	0.004482	0	0
CSMD3	114788	broad.mit.edu	37	8	113323244	113323244	+	Silent	SNP	C	C	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr8:113323244C>A	uc003ynu.2	-	50	8007	c.7848G>T	c.(7846-7848)GGG>GGT	p.G2616G	CSMD3_uc003yns.2_Silent_p.G1818G|CSMD3_uc003ynt.2_Silent_p.G2576G|CSMD3_uc011lhx.1_Silent_p.G2512G|CSMD3_uc003ynw.1_Silent_p.G327G	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	2616	Extracellular (Potential).|Sushi 14.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						ATGCATGATACCCATAGGAAG	0.463			NA								HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			43	81					1.68508e-10	2.31181e-10	0.009718	1	0
CSMD3	114788	broad.mit.edu	37	8	113516125	113516125	+	Silent	SNP	T	T	C			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr8:113516125T>C	uc003ynu.2	-	30	5136	c.4977A>G	c.(4975-4977)CAA>CAG	p.Q1659Q	CSMD3_uc003yns.2_Silent_p.Q931Q|CSMD3_uc003ynt.2_Silent_p.Q1619Q|CSMD3_uc011lhx.1_Silent_p.Q1555Q	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	1659	Extracellular (Potential).|CUB 9.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						ACTTGCTGTCTTGAAAACTTC	0.348			NA								HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			27	85					0	0	0.005443	0	0
CSMD3	114788	broad.mit.edu	37	8	113988189	113988189	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr8:113988189C>A	uc003ynu.2	-	7	1378	c.1219G>T	c.(1219-1221)GAC>TAC	p.D407Y	CSMD3_uc003ynt.2_Missense_Mutation_p.D367Y|CSMD3_uc011lhx.1_Intron	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	407	Extracellular (Potential).					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						GTGTTGGGGTCCAGACCTGAA	0.478			NA								HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			9	162					3.86212e-05	4.43255e-05	0.008291	1	0
CSMD3	114788	broad.mit.edu	37	8	114111174	114111174	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr8:114111174C>T	uc003ynu.2	-	5	887	c.728G>A	c.(727-729)GGA>GAA	p.G243E	CSMD3_uc003ynt.2_Missense_Mutation_p.G203E|CSMD3_uc011lhx.1_Missense_Mutation_p.G243E|CSMD3_uc010mcx.1_Missense_Mutation_p.G243E	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	243	Extracellular (Potential).|CUB 2.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						TCTCATTGTTCCTCCACAAGC	0.388			NA								HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			10	56					0	0	0.008291	0	0
TG	7038	broad.mit.edu	37	8	133941335	133941335	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr8:133941335G>C	uc003ytw.2	+	23	4755	c.4714G>C	c.(4714-4716)GAG>CAG	p.E1572Q	TG_uc010mdw.2_Missense_Mutation_p.E331Q|TG_uc011ljb.1_Missense_Mutation_p.E5Q|TG_uc003ytx.1_RNA	NM_003235	NP_003226	P01266	THYG_HUMAN	thyroglobulin precursor	1572					hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			ovary(8)|breast(4)|pancreas(1)|central_nervous_system(1)|skin(1)	15	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		GCAGAAGTTTGAGAAGGTTCC	0.453			NA											4	130					0	0	0.000602	0	0
GPAA1	8733	broad.mit.edu	37	8	145138042	145138042	+	Silent	SNP	G	G	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr8:145138042G>T	uc003zax.2	+	2	200	c.90G>T	c.(88-90)GTG>GTT	p.V30V	GPAA1_uc003zav.1_5'UTR|GPAA1_uc003zaw.1_Intron	NM_003801	NP_003792	O43292	GPAA1_HUMAN	glycosylphosphatidylinositol anchor attachment	30	Helical; (Potential).				attachment of GPI anchor to protein|C-terminal protein lipidation|protein complex assembly|protein retention in ER lumen	GPI-anchor transamidase complex	tubulin binding				0	all_cancers(97;2.87e-11)|all_epithelial(106;2.16e-09)|Lung NSC(106;5.89e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;3.38e-41)|Epithelial(56;6.02e-40)|all cancers(56;2.11e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			TGAGCTACGTGGCGGGCATCG	0.672			NA											4	31					2.56e-06	3.05268e-06	0.009096	1	0
PTPRD	5789	broad.mit.edu	37	9	8485784	8485784	+	Silent	SNP	G	G	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr9:8485784G>A	uc003zkk.2	-	27	3744	c.3033C>T	c.(3031-3033)TTC>TTT	p.F1011F	PTPRD_uc003zkp.2_Intron|PTPRD_uc003zkq.2_Intron|PTPRD_uc003zkr.2_Intron|PTPRD_uc003zks.2_Intron|PTPRD_uc003zkl.2_Silent_p.F1002F|PTPRD_uc003zkm.2_Silent_p.F998F|PTPRD_uc003zkn.2_Intron|PTPRD_uc003zko.2_Intron	NM_002839	NP_002830	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	1011	Fibronectin type-III 7.|Extracellular (Potential).				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			lung(14)|large_intestine(3)|ovary(2)|breast(2)|urinary_tract(1)	22		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		GCAGTGTCCTGAACTGGACAC	0.448			NA								TSP Lung(15;0.13)			4	15					0	0	0.001984	0	0
BNC2	54796	broad.mit.edu	37	9	16435569	16435569	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr9:16435569G>A	uc003zml.2	-	6	2763	c.2623C>T	c.(2623-2625)CGC>TGC	p.R875C	BNC2_uc011lmw.1_Missense_Mutation_p.R780C|BNC2_uc003zmm.2_Missense_Mutation_p.R833C|BNC2_uc003zmq.1_Missense_Mutation_p.R889C|BNC2_uc003zmr.1_Missense_Mutation_p.R912C|BNC2_uc003zmp.1_Missense_Mutation_p.R903C|BNC2_uc010mij.1_Missense_Mutation_p.R797C|BNC2_uc011lmv.1_Missense_Mutation_p.R701C|BNC2_uc003zmo.1_Missense_Mutation_p.R797C|BNC2_uc003zmj.2_Missense_Mutation_p.R640C|BNC2_uc003zmk.2_RNA|BNC2_uc003zmi.2_Missense_Mutation_p.R640C|BNC2_uc003zmn.1_Missense_Mutation_p.R640C	NM_017637	NP_060107	Q6ZN30	BNC2_HUMAN	basonuclin 2	875					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	zinc ion binding			ovary(2)|central_nervous_system(1)	3				GBM - Glioblastoma multiforme(50;9.01e-08)		CGGCTTCGGCGAGAGGGGAAT	0.498			NA											4	32					0	0	0.009096	0	0
BNC2	54796	broad.mit.edu	37	9	16552765	16552765	+	Splice_Site	SNP	T	T	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr9:16552765T>A	uc003zml.2	-	5	574	c.434_splice	c.e5-1	p.A145_splice	BNC2_uc011lmw.1_Splice_Site_p.A50_splice|BNC2_uc003zmm.2_Splice_Site_p.A103_splice|BNC2_uc003zmq.1_Splice_Site_p.A159_splice|BNC2_uc003zmr.1_Splice_Site_p.A182_splice|BNC2_uc003zmp.1_Splice_Site_p.A173_splice|BNC2_uc010mij.1_Splice_Site_p.A67_splice|BNC2_uc011lmv.1_Splice_Site|BNC2_uc003zmo.1_Splice_Site_p.A67_splice	NM_017637	NP_060107	Q6ZN30	BNC2_HUMAN	basonuclin 2						regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	zinc ion binding			ovary(2)|central_nervous_system(1)	3				GBM - Glioblastoma multiforme(50;9.01e-08)		TATCCAAGGCTGTGGTGGTCC	0.512			NA											13	43					0	0	0.001855	0	0
CNTFR	1271	broad.mit.edu	37	9	34564690	34564690	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr9:34564690G>T	uc003zup.1	-	4	507	c.226C>A	c.(226-228)CTC>ATC	p.L76I	CNTFR_uc003zuq.1_Missense_Mutation_p.L76I	NM_147164	NP_671693	P26992	CNTFR_HUMAN	ciliary neurotrophic factor receptor	76	Ig-like C2-type.				nervous system development	anchored to membrane|extrinsic to membrane|plasma membrane	ciliary neurotrophic factor receptor activity|receptor binding			ovary(3)|central_nervous_system(1)|skin(1)	5	all_epithelial(49;0.0899)		STAD - Stomach adenocarcinoma(86;0.212)	GBM - Glioblastoma multiforme(74;0.00494)		AGGCCATGGAGCACCAGCTGA	0.627			NA											10	46					7.48243e-07	9.1057e-07	0.006214	1	0
ARID3C	138715	broad.mit.edu	37	9	34623453	34623454	+	Nonsense_Mutation	DNP	GC	GC	TT			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	GC	GC	-	-	GC	GC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr9:34623453_34623454GC>TT	uc011lon.1	-	4	833_834	c.833_834GC>AA	c.(832-834)TGC>TAA	p.C278*	DCTN3_uc003zuw.1_5'Flank|DCTN3_uc003zux.1_5'Flank	NM_001017363	NP_001017363	A6NKF2	ARI3C_HUMAN	AT rich interactive domain 3C (BRIGHT- like)	278	Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(1)	1	all_epithelial(49;0.102)		STAD - Stomach adenocarcinoma(86;0.178)	GBM - Glioblastoma multiforme(74;0.175)		TCAGCTGAGCGCATGCATGCGC	0.639			NA											57	221					0	0	0.004672	0	0
ZNF658	26149	broad.mit.edu	37	9	40773112	40773112	+	Silent	SNP	T	T	C			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr9:40773112T>C	uc004abs.2	-	5	2315	c.2163A>G	c.(2161-2163)AAA>AAG	p.K721K	ZNF658_uc010mmm.1_Intron|ZNF658_uc010mmn.1_Silent_p.K721K	NM_033160	NP_149350	Q5TYW1	ZN658_HUMAN	zinc finger protein 658	721	C2H2-type 13.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1				GBM - Glioblastoma multiforme(29;0.02)|Lung(182;0.0681)		GGGCAAATGTTTTCTCACATT	0.393			NA											9	375					0	0	0.001855	0	0
FAM75A6	389730	broad.mit.edu	37	9	43627756	43627756	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr9:43627756G>T	uc011lrb.1	-	4	960	c.931C>A	c.(931-933)CAG>AAG	p.Q311K		NM_001145196	NP_001138668	Q5VVP1	F75A6_HUMAN	hypothetical protein LOC389730	311						integral to membrane					0						GCTTCCATCTGACAGGTCTCT	0.532			NA											9	366					0.000274275	0.000305179	0.004482	1	0
PGM5	5239	broad.mit.edu	37	9	71006565	71006565	+	Silent	SNP	G	G	C			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr9:71006565G>C	uc004agr.2	+	5	1042	c.813G>C	c.(811-813)CTG>CTC	p.L271L		NM_021965	NP_068800	Q15124	PGM5_HUMAN	phosphoglucomutase 5	271					cell adhesion|cellular calcium ion homeostasis|glucose metabolic process	costamere|dystrophin-associated glycoprotein complex|focal adhesion|intercalated disc|internal side of plasma membrane|sarcolemma|spot adherens junction|stress fiber|Z disc	intramolecular transferase activity, phosphotransferases|magnesium ion binding|structural molecule activity			ovary(1)|pancreas(1)	2						ACCCAAACCTGACATATGCAA	0.493			NA											15	74					0	0	0.007413	0	0
Unknown	0	broad.mit.edu	37	9	90747437	90747437	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr9:90747437G>T	uc011lti.1	-	4	544	c.515C>A	c.(514-516)GCC>GAC	p.A172D						SubName: Full=cDNA FLJ59639;												NA						TGGGGTGGAGGCCAGATCCTG	0.612			NA											18	144					4.31634e-10	5.84555e-10	0.002445	1	0
NOL8	55035	broad.mit.edu	37	9	95080959	95080959	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr9:95080959C>G	uc004arv.2	-	6	764	c.427G>C	c.(427-429)GTG>CTG	p.V143L	NOL8_uc010mqw.2_5'Flank|NOL8_uc004arw.2_Intron|NOL8_uc011ltw.1_Missense_Mutation_p.V75L|NOL8_uc004arx.2_Missense_Mutation_p.V143L	NM_017948	NP_060418	Q76FK4	NOL8_HUMAN	nucleolar protein 8	143					DNA replication|positive regulation of cell growth	nucleolus	nucleotide binding|protein binding|RNA binding			ovary(1)	1						AATTTGCTCACAACCCAATTC	0.279			NA											3	20					0	0	0.004672	0	0
SVEP1	79987	broad.mit.edu	37	9	113151817	113151817	+	Silent	SNP	C	C	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr9:113151817C>T	uc010mtz.2	-	41	10210	c.9873G>A	c.(9871-9873)GTG>GTA	p.V3291V	SVEP1_uc010mty.2_Silent_p.V1217V	NM_153366	NP_699197	Q4LDE5	SVEP1_HUMAN	polydom	3291	Sushi 31.				cell adhesion	cytoplasm|extracellular region|membrane	calcium ion binding			ovary(7)	7						TGCATATTGCCACCCCTCCAC	0.433			NA											26	54					0	0	0.008361	0	0
DAB2IP	153090	broad.mit.edu	37	9	124544669	124544669	+	Silent	SNP	G	G	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr9:124544669G>A	uc004bln.2	+	16	3447	c.3378G>A	c.(3376-3378)CAG>CAA	p.Q1126Q	DAB2IP_uc004blo.2_Silent_p.Q1030Q|DAB2IP_uc004blp.2_Silent_p.Q559Q	NM_032552	NP_115941	Q5VWQ8	DAB2P_HUMAN	disabled homolog 2 interacting protein isoform	1154	Potential.				activation of JUN kinase activity|apoptosis in response to endoplasmic reticulum stress|cellular response to epidermal growth factor stimulus|cellular response to tumor necrosis factor|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of catenin import into nucleus|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of epithelial cell migration|negative regulation of epithelial cell proliferation|negative regulation of epithelial to mesenchymal transition|negative regulation of fibroblast proliferation|negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of MAP kinase activity|negative regulation of NF-kappaB transcription factor activity|negative regulation of Ras GTPase activity|negative regulation of transcription from RNA polymerase II promoter|positive regulation of apoptosis|positive regulation of transcription from RNA polymerase II promoter	cytoplasm|intrinsic to internal side of plasma membrane	14-3-3 protein binding|death receptor binding|mitogen-activated protein kinase kinase kinase binding|protein homodimerization activity|protein phosphatase 2A binding|Ras GTPase activator activity|signaling adaptor activity			ovary(1)|central_nervous_system(1)	2						CCCTGACCCAGCTGAAAGAGA	0.582			NA											4	126					0	0	0.009096	0	0
LRRC8A	56262	broad.mit.edu	37	9	131669876	131669876	+	Nonsense_Mutation	SNP	A	A	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr9:131669876A>T	uc004bwl.3	+	3	687	c.433A>T	c.(433-435)AAA>TAA	p.K145*	LRRC8A_uc010myp.2_Nonsense_Mutation_p.K145*|LRRC8A_uc010myq.2_Nonsense_Mutation_p.K145*	NM_019594	NP_062540	Q8IWT6	LRC8A_HUMAN	leucine rich repeat containing 8 family, member	145	Helical; (Potential).				pre-B cell differentiation	integral to membrane					0						CTTCTGGTTCAAATTCCCGCG	0.567			NA											31	41					0	0	0.003755	0	0
CAMSAP1	157922	broad.mit.edu	37	9	138715101	138715101	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr9:138715101G>A	uc004cgr.3	-	11	1406	c.1406C>T	c.(1405-1407)GCG>GTG	p.A469V	CAMSAP1_uc004cgq.3_Missense_Mutation_p.A359V|CAMSAP1_uc010nbg.2_Missense_Mutation_p.A191V	NM_015447	NP_056262	Q5T5Y3	CAMP1_HUMAN	calmodulin regulated spectrin-associated protein	469						cytoplasm|microtubule				ovary(1)|central_nervous_system(1)|pancreas(1)	3				OV - Ovarian serous cystadenocarcinoma(145;1.4e-06)|Epithelial(140;1.11e-05)		TGGCTGGGACGCAGGCCTGAA	0.587			NA											9	54					0	0	0.004482	0	0
MAMDC4	158056	broad.mit.edu	37	9	139749013	139749013	+	Missense_Mutation	SNP	T	T	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr9:139749013T>A	uc004cjs.2	+	8	869	c.819T>A	c.(817-819)TTT>TTA	p.F273L	MAMDC4_uc011mej.1_5'UTR	NM_206920	NP_996803	Q6UXC1	AEGP_HUMAN	apical early endosomal glycoprotein precursor	273	MAM 2.|Extracellular (Potential).				protein transport	integral to membrane				breast(4)|upper_aerodigestive_tract(2)|central_nervous_system(1)	7	all_cancers(76;0.0763)|all_epithelial(76;0.198)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;1.52e-05)|Epithelial(140;0.000171)		CCACCGACTTTGAGACAGGCC	0.701			NA											10	6					0	0	0.001368	0	0
PLCXD1	55344	broad.mit.edu	37	X	215875	215875	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chrX:215875C>T	uc004cpc.2	+	7	1157	c.845C>T	c.(844-846)GCG>GTG	p.A282V	PLCXD1_uc011mgx.1_RNA	NM_018390	NP_060860	Q9NUJ7	PLCX1_HUMAN	phosphatidylinositol-specific phospholipase C, X	282					intracellular signal transduction|lipid metabolic process		phospholipase C activity				0		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				CGGCTGAGCGCGTGGGTCCGA	0.662			NA											16	22					0	0	0.007413	0	0
PTCHD1	139411	broad.mit.edu	37	X	23412154	23412154	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chrX:23412154C>A	uc004dal.3	+	3	2527	c.2519C>A	c.(2518-2520)GCC>GAC	p.A840D		NM_173495	NP_775766	Q96NR3	PTHD1_HUMAN	patched domain containing 1	840	Helical; (Potential).				cognition|smoothened signaling pathway	integral to membrane|plasma membrane	hedgehog receptor activity			ovary(4)|kidney(1)|skin(1)	6						CACTGCTTTGCCATTTTACCT	0.418			NA											8	185					0.000157383	0.000176986	0.00308	1	0
CXorf21	80231	broad.mit.edu	37	X	30578175	30578175	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chrX:30578175C>A	uc004dcg.1	-	3	574	c.298G>T	c.(298-300)GTT>TTT	p.V100F		NM_025159	NP_079435	Q9HAI6	CX021_HUMAN	hypothetical protein LOC80231	100										ovary(1)	1						CATATTTCAACTGCAGCCAAG	0.443			NA											7	222					0.00198382	0.00213469	0.001984	1	0
DMD	1756	broad.mit.edu	37	X	32305789	32305789	+	Silent	SNP	T	T	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chrX:32305789T>A	uc004dda.1	-	43	6391	c.6147A>T	c.(6145-6147)TCA>TCT	p.S2049S	DMD_uc004dcw.2_Silent_p.S705S|DMD_uc004dcx.2_Silent_p.S708S|DMD_uc004dcz.2_Silent_p.S1926S|DMD_uc004dcy.1_Silent_p.S2045S|DMD_uc004ddb.1_Silent_p.S2041S|DMD_uc010ngo.1_Intron|DMD_uc010ngn.1_RNA	NM_004006	NP_003997	P11532	DMD_HUMAN	dystrophin Dp427m isoform	2049	Spectrin 14.				muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			ovary(3)|pancreas(2)|large_intestine(1)	6		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				CAATCCGACCTGAGCTTTGTT	0.338			NA											5	26					0	0	0.000602	0	0
FAM47B	170062	broad.mit.edu	37	X	34961456	34961456	+	Nonsense_Mutation	SNP	G	G	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chrX:34961456G>T	uc004ddi.1	+	1	526	c.508G>T	c.(508-510)GAG>TAG	p.E170*		NM_152631	NP_689844	Q8NA70	FA47B_HUMAN	hypothetical protein LOC170062	170										ovary(3)|breast(1)	4						TGAGGCCCGGGAGAAGACAAC	0.597			NA											23	15					2.89027e-11	4.01756e-11	0.002299	1	0
CXorf22	170063	broad.mit.edu	37	X	35993266	35993266	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chrX:35993266C>A	uc004ddj.2	+	14	2316	c.2257C>A	c.(2257-2259)CCT>ACT	p.P753T	CXorf22_uc010ngv.2_Intron	NM_152632	NP_689845	Q6ZTR5	CX022_HUMAN	hypothetical protein LOC170063	753										large_intestine(1)|lung(1)|ovary(1)	3						TTTTTCAGGGCCTTCTGTCCT	0.289			NA											13	32					4.36969e-10	5.90095e-10	0.001855	1	0
FAM47C	442444	broad.mit.edu	37	X	37026518	37026518	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chrX:37026518C>A	uc004ddl.1	+	1	49	c.35C>A	c.(34-36)TCC>TAC	p.S12Y		NM_001013736	NP_001013758	Q5HY64	FA47C_HUMAN	hypothetical protein LOC442444	12										ovary(3)	3						CGGCCCAGTTCCCCGGGCATG	0.662			NA											5	19					0.000602214	0.000665384	0.000602	1	0
SYTL5	94122	broad.mit.edu	37	X	37984667	37984667	+	Missense_Mutation	SNP	T	T	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chrX:37984667T>A	uc004ddu.2	+	17	2492	c.1958T>A	c.(1957-1959)ATA>AAA	p.I653K	SYTL5_uc004ddv.2_Missense_Mutation_p.I653K|SYTL5_uc004ddx.2_Missense_Mutation_p.I675K	NM_001163335	NP_001156807	Q8TDW5	SYTL5_HUMAN	synaptotagmin-like 5 isoform 1	653	C2 2.				intracellular protein transport	membrane	metal ion binding|Rab GTPase binding			skin(1)	1						CCCCAGGATATAAAGAATGTT	0.433			NA											27	68					0	0	0.00632	0	0
SRPX	8406	broad.mit.edu	37	X	38033550	38033550	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chrX:38033550G>A	uc004ddy.1	-	3	298	c.212C>T	c.(211-213)GCC>GTC	p.A71V	SRPX_uc004ddz.1_Missense_Mutation_p.A51V|SRPX_uc011mkh.1_Missense_Mutation_p.A71V|SRPX_uc011mki.1_Missense_Mutation_p.A71V	NM_006307	NP_006298	P78539	SRPX_HUMAN	sushi-repeat-containing protein, X-linked	71	Sushi 1.				cell adhesion	cell surface|membrane					0						TCCTTGAGGGGCCCTGCAGTA	0.517			NA											21	14					0	0	0.001882	0	0
GRIPAP1	56850	broad.mit.edu	37	X	48832429	48832429	+	Splice_Site	SNP	C	C	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chrX:48832429C>A	uc004dly.1	-	24	2313	c.2278_splice	c.e24+1	p.D760_splice		NM_020137	NP_064522	Q4V328	GRAP1_HUMAN	GRIP1 associated protein 1 isoform 1							early endosome				breast(2)|kidney(1)	3						GGGACACTGACCGATCCGGCT	0.617			NA											6	20					0.000157383	0.000176986	0.00308	1	0
DGKK	139189	broad.mit.edu	37	X	50133404	50133405	+	Missense_Mutation	DNP	CC	CC	AA			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chrX:50133404_50133405CC>AA	uc010njr.1	-	12	1907_1908	c.1847_1848GG>TT	c.(1846-1848)TGG>TTT	p.W616F		NM_001013742	NP_001013764	Q5KSL6	DGKK_HUMAN	diacylglycerol kinase kappa	616	DAGKc.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|diacylglycerol metabolic process|intracellular signal transduction|platelet activation|response to oxidative stress	cytoplasm|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			ovary(1)|kidney(1)	2	Ovarian(276;0.236)					TCATCACACTCCATCTGAAATG	0.391			NA											23	82					0	0	0.004672	0	0
HUWE1	10075	broad.mit.edu	37	X	53675171	53675171	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chrX:53675171G>A	uc004dsp.2	-	5	530	c.128C>T	c.(127-129)ACA>ATA	p.T43I		NM_031407	NP_113584	Q7Z6Z7	HUWE1_HUMAN	HECT, UBA and WWE domain containing 1	43					base-excision repair|cell differentiation|histone ubiquitination|protein monoubiquitination|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	DNA binding|protein binding|ubiquitin-protein ligase activity			ovary(8)|large_intestine(4)|breast(4)|kidney(1)	17						AATGTTCCATGTTTTGATCTG	0.388			NA											30	19					0	0	0.008361	0	0
EFNB1	1947	broad.mit.edu	37	X	68060320	68060320	+	Silent	SNP	C	C	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chrX:68060320C>T	uc004dxd.3	+	5	1644	c.864C>T	c.(862-864)CCC>CCT	p.P288P	EFNB1_uc004dxe.2_Silent_p.P288P	NM_004429	NP_004420	P98172	EFNB1_HUMAN	ephrin-B1 precursor	288	Cytoplasmic (Potential).				cell adhesion|cell-cell signaling	integral to plasma membrane|soluble fraction|synapse	ephrin receptor binding				0						TGGCCAGTCCCAAGGGGGGCA	0.607			NA											4	18					0	0	0.009096	0	0
KIAA2022	340533	broad.mit.edu	37	X	73960665	73960665	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chrX:73960665G>A	uc004eby.2	-	3	4344	c.3727C>T	c.(3727-3729)CGT>TGT	p.R1243C		NM_001008537	NP_001008537	Q5QGS0	K2022_HUMAN	hypothetical protein LOC340533	1243					base-excision repair, gap-filling|DNA replication proofreading|DNA replication, removal of RNA primer|nucleotide-excision repair, DNA gap filling|regulation of mitotic cell cycle|S phase of mitotic cell cycle	delta DNA polymerase complex	3'-5'-exodeoxyribonuclease activity|DNA-directed DNA polymerase activity			ovary(7)|large_intestine(4)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	15						CTTCCCCCACGGCCAATGCCA	0.493			NA											21	15					0	0	0.003954	0	0
P2RY10	27334	broad.mit.edu	37	X	78216969	78216969	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chrX:78216969C>T	uc004ede.2	+	4	1321	c.952C>T	c.(952-954)CGC>TGC	p.R318C	P2RY10_uc004edf.2_Missense_Mutation_p.R318C	NM_014499	NP_055314	O00398	P2Y10_HUMAN	G-protein coupled purinergic receptor P2Y10	318	Cytoplasmic (Potential).					integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			ovary(2)|lung(2)|breast(1)	5						CCAACTATCCCGCCATGGCAG	0.443			NA											57	37					0	0	0.00361	0	0
PABPC5	140886	broad.mit.edu	37	X	90691098	90691098	+	Silent	SNP	G	G	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chrX:90691098G>A	uc004efg.2	+	2	962	c.522G>A	c.(520-522)CAG>CAA	p.Q174Q	PABPC5_uc004eff.1_Silent_p.Q10Q	NM_080832	NP_543022	Q96DU9	PABP5_HUMAN	poly(A) binding protein, cytoplasmic 5	174	RRM 2.					cytoplasm	nucleotide binding|RNA binding			ovary(1)|lung(1)|pancreas(1)	3						ACAACCGCCAGGTGTATGTTG	0.502			NA											19	45					0	0	0.006122	0	0
BTK	695	broad.mit.edu	37	X	100630242	100630242	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chrX:100630242G>C	uc004ehg.2	-	2	224	c.31C>G	c.(31-33)CTG>GTG	p.L11V	BTK_uc010nnn.2_Missense_Mutation_p.L11V|BTK_uc010nno.2_Missense_Mutation_p.L45V|BTK_uc004ehi.2_Missense_Mutation_p.L11V	NM_000061	NP_000052	Q06187	BTK_HUMAN	Bruton agammaglobulinemia tyrosine kinase	11	PH.		L -> P (in XLA).		calcium-mediated signaling|induction of apoptosis by extracellular signals|mesoderm development	cytosol|membrane raft|nucleus|plasma membrane	ATP binding|identical protein binding|metal ion binding|non-membrane spanning protein tyrosine kinase activity|phosphatidylinositol-3,4,5-trisphosphate binding			lung(3)|central_nervous_system(2)|ovary(1)	6						GATCGCTTCAGAAAGATGCTC	0.438			NA							Agammaglobulinemia_X-linked				44	110					0	0	0.002522	0	0
ZMAT1	84460	broad.mit.edu	37	X	101138621	101138621	+	Missense_Mutation	SNP	A	A	C			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chrX:101138621A>C	uc004eim.2	-	2	4763	c.1265T>G	c.(1264-1266)CTT>CGT	p.L422R	ZMAT1_uc011mrl.1_Missense_Mutation_p.L593R|ZMAT1_uc004ein.2_Missense_Mutation_p.L422R|ZMAT1_uc011mrm.1_Missense_Mutation_p.L422R	NM_032441	NP_115817	Q5H9K5	ZMAT1_HUMAN	zinc finger, matrin type 1 isoform 3	422						nucleus	zinc ion binding			ovary(1)	1						TCGATGCTTAAGCTTTCCTGA	0.373			NA											6	122					0	0	0.006214	0	0
COL4A5	1287	broad.mit.edu	37	X	107938500	107938500	+	Missense_Mutation	SNP	A	A	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chrX:107938500A>T	uc004enz.1	+	51	5027	c.4825A>T	c.(4825-4827)ACA>TCA	p.T1609S	COL4A5_uc011mso.1_Missense_Mutation_p.T1606S|COL4A5_uc011msp.1_Missense_Mutation_p.T285S	NM_033380	NP_203699	P29400	CO4A5_HUMAN	type IV collagen alpha 5 isoform 2 precursor	1603	Collagen IV NC1.		Missing (in APSX).		axon guidance	collagen type IV	extracellular matrix structural constituent|protein binding			ovary(3)|central_nervous_system(1)	4						TTTATAGCATACAAGTGCAGG	0.483			NA							Alport_syndrome_with_Diffuse_Leiomyomatosis				23	93					0	0	0.00632	0	0
CHRDL1	91851	broad.mit.edu	37	X	109931883	109931883	+	Silent	SNP	G	G	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chrX:109931883G>A	uc004eou.3	-	9	1276	c.927C>T	c.(925-927)TGC>TGT	p.C309C	CHRDL1_uc004eov.2_Silent_p.C303C|CHRDL1_uc004eow.2_Silent_p.C308C|CHRDL1_uc010nps.2_Silent_p.C308C|CHRDL1_uc004eot.2_Silent_p.C229C|CHRDL1_uc011mss.1_Silent_p.C223C	NM_001143981	NP_001137453	Q9BU40	CRDL1_HUMAN	chordin-like 1 isoform 1 precursor	302	VWFC 3.				BMP signaling pathway|cell differentiation|nervous system development|ossification	extracellular region					0						GAGGATACTTGCAGGGGTATC	0.463			NA											43	135					0	0	0.00874	0	0
LAMP2	3920	broad.mit.edu	37	X	119575734	119575734	+	Missense_Mutation	SNP	T	T	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chrX:119575734T>A	uc004est.3	-	8	1124	c.944A>T	c.(943-945)AAT>ATT	p.N315I	LAMP2_uc004ess.3_Missense_Mutation_p.N315I|LAMP2_uc011mtz.1_Missense_Mutation_p.N204I|LAMP2_uc011mua.1_Missense_Mutation_p.N268I|LAMP2_uc010nqp.1_Missense_Mutation_p.N315I	NM_002294	NP_002285	P13473	LAMP2_HUMAN	lysosomal-associated membrane protein 2 isoform	315	Lumenal (Potential).|Second lumenal domain.				platelet activation|platelet degranulation	endosome membrane|integral to membrane|late endosome|lysosomal membrane|membrane fraction|plasma membrane|platelet dense granule membrane				ovary(1)	1						GAGATTGTTATTTGCAATGCT	0.333			NA											24	87					0	0	0.004656	0	0
IGSF1	3547	broad.mit.edu	37	X	130409258	130409258	+	Missense_Mutation	SNP	A	A	C			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chrX:130409258A>C	uc004ewd.2	-	17	3425	c.3187T>G	c.(3187-3189)TTA>GTA	p.L1063V	IGSF1_uc004ewe.3_Missense_Mutation_p.L1057V|IGSF1_uc004ewf.2_Missense_Mutation_p.L1043V	NM_001555	NP_001546	Q8N6C5	IGSF1_HUMAN	immunoglobulin superfamily, member 1 isoform 1	1063	Extracellular (Potential).				regulation of transcription, DNA-dependent	extracellular region|integral to membrane	inhibin beta-A binding|inhibin beta-B binding			ovary(3)|lung(1)|central_nervous_system(1)	5						TTGGGGAGTAAGCCTGGAAGA	0.517			NA											7	150					0	0	0.00308	0	0
GPR112	139378	broad.mit.edu	37	X	135427278	135427278	+	Silent	SNP	T	T	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chrX:135427278T>A	uc004ezu.1	+	6	1704	c.1413T>A	c.(1411-1413)CCT>CCA	p.P471P	GPR112_uc010nsb.1_Silent_p.P266P|GPR112_uc010nsc.1_Silent_p.P238P	NM_153834	NP_722576	Q8IZF6	GP112_HUMAN	G-protein coupled receptor 112	471	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(5)|large_intestine(2)|skin(2)|lung(1)|breast(1)|pancreas(1)	12	Acute lymphoblastic leukemia(192;0.000127)					CACCTGAGCCTGTGCTCATCT	0.448			NA											5	78					0	0	0.000602	0	0
GPR112	139378	broad.mit.edu	37	X	135431636	135431637	+	Missense_Mutation	DNP	CC	CC	AA			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chrX:135431636_135431637CC>AA	uc004ezu.1	+	6	6062_6063	c.5771_5772CC>AA	c.(5770-5772)GCC>GAA	p.A1924E	GPR112_uc010nsb.1_Missense_Mutation_p.A1719E|GPR112_uc010nsc.1_Missense_Mutation_p.A1691E	NM_153834	NP_722576	Q8IZF6	GP112_HUMAN	G-protein coupled receptor 112	1924	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(5)|large_intestine(2)|skin(2)|lung(1)|breast(1)|pancreas(1)	12	Acute lymphoblastic leukemia(192;0.000127)					ACATTCACAGCCTCTCAGACTG	0.416			NA											5	142					0	0	0.004672	0	0
MAGEC1	9947	broad.mit.edu	37	X	140996176	140996176	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chrX:140996176C>A	uc004fbt.2	+	4	3272	c.2986C>A	c.(2986-2988)CAG>AAG	p.Q996K	MAGEC1_uc010nsl.1_Missense_Mutation_p.Q63K	NM_005462	NP_005453	O60732	MAGC1_HUMAN	melanoma antigen family C, 1	996	MAGE.						protein binding			ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	4	Acute lymphoblastic leukemia(192;6.56e-05)					GGGCATGTCCCAGAACCGCCT	0.502			NA								HNSCC(15;0.026)			48	109					2.64894e-19	4.06343e-19	0.00361	1	0
PDZD4	57595	broad.mit.edu	37	X	153069795	153069795	+	Silent	SNP	G	G	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chrX:153069795G>A	uc004fiz.1	-	8	1573	c.1323C>T	c.(1321-1323)TAC>TAT	p.Y441Y	PDZD4_uc004fiy.1_Silent_p.Y366Y|PDZD4_uc004fix.2_Silent_p.Y345Y|PDZD4_uc004fja.1_Silent_p.Y447Y|PDZD4_uc011mze.1_Silent_p.Y332Y	NM_032512	NP_115901	Q76G19	PDZD4_HUMAN	PDZ domain containing 4	441						cell cortex				breast(1)	1	all_lung(58;3.39e-06)|all_hematologic(71;4.25e-06)|Lung NSC(58;4.7e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					CCGCCAGGTCGTAGAGGCTCT	0.627			NA											4	32					0	0	0.001984	0	0
RPS4Y1	6192	broad.mit.edu	37	Y	2712266	2712266	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chrY:2712266G>T	uc004fqi.2	+	3	273	c.230G>T	c.(229-231)CGA>CTA	p.R77L		NM_001008	NP_000999	P22090	RS4Y1_HUMAN	ribosomal protein S4, Y-linked 1 Y isoform	77	S4 RNA-binding.				endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic small ribosomal subunit|polysome	rRNA binding|structural constituent of ribosome				0						GGCAAGGTTCGAGTGGATGTC	0.423	Melanoma(193;1927 2965 17170 18413)		NA											59	101					2.44918e-20	3.79383e-20	0.00361	1	0
GRIK3	2899	broad.mit.edu	37	1	37356618	37356619	+	Frame_Shift_Ins	INS	-	-	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr1:37356618_37356619insA	uc001caz.2	-	2	329_330	c.194_195insT	c.(193-195)AACfs	p.N65fs	GRIK3_uc001cba.1_Frame_Shift_Ins_p.N65fs	NM_000831	NP_000822	Q13003	GRIK3_HUMAN	glutamate receptor, ionotropic, kainate 3	65	Extracellular (Potential).				negative regulation of synaptic transmission, glutamatergic|regulation of membrane potential|synaptic transmission	cell junction|dendrite cytoplasm|integral to plasma membrane|perikaryon|postsynaptic membrane|terminal button	adenylate cyclase inhibiting metabotropic glutamate receptor activity|extracellular-glutamate-gated ion channel activity|G-protein-coupled receptor binding|kainate selective glutamate receptor activity			ovary(3)|skin(2)|large_intestine(1)|breast(1)	7		Myeloproliferative disorder(586;0.0258)|all_neural(195;0.169)			L-Glutamic Acid(DB00142)	TGTTGATGATGTTGGCAGAAAA	0.5			NA											35	306	---	---	---	---	NA	NA	NA	NA	NA
RHBG	57127	broad.mit.edu	37	1	156351938	156351938	+	Frame_Shift_Del	DEL	C	C	-			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr1:156351938delC	uc010pho.1	+	7	1096	c.1058delC	c.(1057-1059)GCCfs	p.A353fs	RHBG_uc010phm.1_Frame_Shift_Del_p.P186fs|RHBG_uc010phn.1_RNA|RHBG_uc001fos.2_Frame_Shift_Del_p.A284fs|RHBG_uc009wrz.2_Frame_Shift_Del_p.A321fs|RHBG_uc001for.2_Frame_Shift_Del_p.A323fs	NM_020407	NP_065140	Q9H310	RHBG_HUMAN	Rhesus blood group, B glycoprotein	353	Helical; (Potential).				transepithelial ammonium transport	anchored to plasma membrane|basolateral plasma membrane|cytoplasmic vesicle membrane|integral to plasma membrane|spectrin-associated cytoskeleton	ammonia transmembrane transporter activity|ammonium transmembrane transporter activity|ankyrin binding			ovary(2)	2	Hepatocellular(266;0.158)					GTCCTGGGGGCCCTCCTGGGG	0.557			NA											42	201	---	---	---	---	NA	NA	NA	NA	NA
MYO3A	53904	broad.mit.edu	37	10	26463295	26463295	+	Frame_Shift_Del	DEL	A	A	-			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr10:26463295delA	uc001isn.2	+	30	4462	c.4102delA	c.(4102-4104)AAGfs	p.K1368fs	MYO3A_uc009xkp.1_Intron|MYO3A_uc009xkq.1_Intron	NM_017433	NP_059129	Q8NEV4	MYO3A_HUMAN	myosin IIIA	1368	IQ 3.				protein autophosphorylation|response to stimulus|sensory perception of sound|visual perception	cytoplasm|filamentous actin|filopodium|myosin complex	actin binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|plus-end directed microfilament motor activity|protein serine/threonine kinase activity			ovary(6)|stomach(3)|lung(3)|central_nervous_system(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	18						GCAGTTGAGGAAGGACAAGAT	0.433			NA											76	160	---	---	---	---	NA	NA	NA	NA	NA
CPNE8	144402	broad.mit.edu	37	12	39087640	39087640	+	Frame_Shift_Del	DEL	C	C	-			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr12:39087640delC	uc001rls.1	-	15	1046	c.962delG	c.(961-963)GGCfs	p.G321fs	CPNE8_uc001rlr.1_5'UTR	NM_153634	NP_705898	Q86YQ8	CPNE8_HUMAN	copine VIII	321	VWFA.									pancreas(1)	1	Esophageal squamous(101;0.187)	Lung NSC(34;0.137)|Melanoma(24;0.152)|all_lung(34;0.157)				AGCAGGGTTGCCTGATGACAG	0.348			NA											31	80	---	---	---	---	NA	NA	NA	NA	NA
DNAJC14	85406	broad.mit.edu	37	12	56221691	56221699	+	In_Frame_Del	DEL	CCTGCCTGT	CCTGCCTGT	-			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	CCTGCCTGT	CCTGCCTGT	-	-	CCTGCCTGT	CCTGCCTGT	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr12:56221691_56221699delCCTGCCTGT	uc001shx.1	-	2	948_956	c.744_752delACAGGCAGG	c.(742-753)GGACAGGCAGGC>GGC	p.248_251GQAG>G	DNAJC14_uc001shu.1_In_Frame_Del_p.248_251GQAG>G|DNAJC14_uc009zob.1_In_Frame_Del_p.248_251GQAG>G|DNAJC14_uc001shy.1_In_Frame_Del_p.248_251GQAG>G	NM_032364	NP_115740	Q6Y2X3	DJC14_HUMAN	dopamine receptor interacting protein	248_251	Helical; (Potential).				protein folding|protein transport	endoplasmic reticulum membrane|integral to membrane	heat shock protein binding|unfolded protein binding			ovary(3)|large_intestine(1)	4						CCACCAAAAGCCTGCCTGTCCAAGTTGAC	0.536			NA											9	111	---	---	---	---	NA	NA	NA	NA	NA
OR4Q3	441669	broad.mit.edu	37	14	20216093	20216094	+	Frame_Shift_Ins	INS	-	-	T			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr14:20216093_20216094insT	uc010tkt.1	+	1	507_508	c.507_508insT	c.(505-510)TTCTGTfs	p.F169fs		NM_172194	NP_751944	Q8NH05	OR4Q3_HUMAN	olfactory receptor, family 4, subfamily Q,	169_170	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(3)	3	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		AGCTGCCTTTCTGTGGGCCCAA	0.51			NA											13	98	---	---	---	---	NA	NA	NA	NA	NA
CLEC14A	161198	broad.mit.edu	37	14	38724524	38724525	+	Frame_Shift_Ins	INS	-	-	A			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr14:38724524_38724525insA	uc001wum.1	-	1	1050_1051	c.703_704insT	c.(703-705)TGGfs	p.W235fs		NM_175060	NP_778230	Q86T13	CLC14_HUMAN	C-type lectin domain family 14, member A	235	Extracellular (Potential).					integral to membrane	sugar binding			ovary(3)|skin(1)	4	Hepatocellular(127;0.213)|Esophageal squamous(585;0.22)		Lung(238;3.93e-06)|LUAD - Lung adenocarcinoma(48;2.62e-05)|Epithelial(34;0.187)	GBM - Glioblastoma multiforme(112;0.00439)		GAGTTTGTCCCAGCGAGCGCCG	0.629			NA											24	929	---	---	---	---	NA	NA	NA	NA	NA
CDH11	1009	broad.mit.edu	37	16	64984878	64984878	+	Frame_Shift_Del	DEL	C	C	-			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr16:64984878delC	uc002eoi.2	-	12	2120	c.1686delG	c.(1684-1686)CGGfs	p.R562fs	CDH11_uc010cdn.2_RNA|CDH11_uc002eoj.2_Frame_Shift_Del_p.R562fs|CDH11_uc010vin.1_Frame_Shift_Del_p.R436fs	NM_001797	NP_001788	P55287	CAD11_HUMAN	cadherin 11, type 2 preproprotein	562	Cadherin 5.|Extracellular (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion|ossification|skeletal system development	integral to membrane|plasma membrane	calcium ion binding|protein binding			lung(10)|ovary(3)|skin(1)	14		Ovarian(137;0.0973)		OV - Ovarian serous cystadenocarcinoma(108;0.205)		CCTGCTTCTGCCGACTGAACC	0.597			NA	T	USP6	aneurysmal bone cysts					TSP Lung(24;0.17)			15	41	---	---	---	---	NA	NA	NA	NA	NA
JPH3	57338	broad.mit.edu	37	16	87678356	87678356	+	Frame_Shift_Del	DEL	G	G	-			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr16:87678356delG	uc002fkd.2	+	2	1129	c.875delG	c.(874-876)TGGfs	p.W292fs	JPH3_uc010vou.1_RNA	NM_020655	NP_065706	Q8WXH2	JPH3_HUMAN	junctophilin 3	292	Cytoplasmic (Potential).|MORN 7.				calcium ion transport into cytosol|regulation of ryanodine-sensitive calcium-release channel activity	integral to membrane|junctional sarcoplasmic reticulum membrane|plasma membrane	protein binding			ovary(1)|pancreas(1)	2				BRCA - Breast invasive adenocarcinoma(80;0.0287)		GTGGGCGAGTGGAAGAACGAC	0.672			NA											17	93	---	---	---	---	NA	NA	NA	NA	NA
GAS2L2	246176	broad.mit.edu	37	17	34079564	34079564	+	Frame_Shift_Del	DEL	G	G	-			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr17:34079564delG	uc002hjv.1	-	1	334	c.306delC	c.(304-306)GCCfs	p.A102fs		NM_139285	NP_644814	Q8NHY3	GA2L2_HUMAN	growth arrest-specific 2 like 2	102	CH.				cell cycle arrest	cytoplasm|cytoskeleton				ovary(1)|skin(1)	2		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		CTGGCTGGGCGGCCCCATTGC	0.617			NA											54	159	---	---	---	---	NA	NA	NA	NA	NA
ACACA	31	broad.mit.edu	37	17	35615290	35615290	+	Frame_Shift_Del	DEL	G	G	-			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr17:35615290delG	uc002hnm.2	-	13	1586	c.1395delC	c.(1393-1395)GCCfs	p.A465fs	ACACA_uc002hnk.2_Frame_Shift_Del_p.A387fs|ACACA_uc002hnl.2_Frame_Shift_Del_p.A407fs|ACACA_uc002hnn.2_Frame_Shift_Del_p.A465fs|ACACA_uc002hno.2_Frame_Shift_Del_p.A502fs|ACACA_uc010cuz.2_Frame_Shift_Del_p.A465fs	NM_198836	NP_942133	Q13085	ACACA_HUMAN	acetyl-Coenzyme A carboxylase alpha isoform 2	465	Biotin carboxylation.|ATP-grasp.				acetyl-CoA metabolic process|energy reserve metabolic process|fatty acid biosynthetic process|long-chain fatty-acyl-CoA biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|triglyceride biosynthetic process	cytosol	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			large_intestine(1)|ovary(1)	2		Breast(25;0.00157)|Ovarian(249;0.15)			Biotin(DB00121)	GAATCCCCATGGCAATCTGAA	0.363	Colon(23;82 258 739 2117 10493 24037 27661 34815 35438 36249)		NA											26	76	---	---	---	---	NA	NA	NA	NA	NA
HOXB3	3213	broad.mit.edu	37	17	46628126	46628126	+	Frame_Shift_Del	DEL	G	G	-			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr17:46628126delG	uc002inn.2	-	2	1266	c.866delC	c.(865-867)CCGfs	p.P289fs	HOXB3_uc010wlm.1_Frame_Shift_Del_p.P216fs|HOXB3_uc010dbf.2_Frame_Shift_Del_p.P289fs|HOXB3_uc010dbg.2_Frame_Shift_Del_p.P289fs|HOXB3_uc002ino.2_Frame_Shift_Del_p.P289fs|HOXB3_uc010wlk.1_Frame_Shift_Del_p.P157fs|HOXB3_uc010wll.1_Frame_Shift_Del_p.P216fs	NM_002146	NP_002137	P14651	HXB3_HUMAN	homeobox B3	289					angiogenesis	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						GGGTGGGGACGGGCTCTCGTA	0.677			NA									OREG0024516	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	63	161	---	---	---	---	NA	NA	NA	NA	NA
ALPK2	115701	broad.mit.edu	37	18	56204617	56204617	+	Frame_Shift_Del	DEL	G	G	-			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr18:56204617delG	uc002lhj.3	-	5	3016	c.2802delC	c.(2800-2802)CCCfs	p.P934fs	ALPK2_uc002lhk.1_Frame_Shift_Del_p.P265fs	NM_052947	NP_443179	Q86TB3	ALPK2_HUMAN	heart alpha-kinase	934							ATP binding|protein serine/threonine kinase activity			ovary(7)|skin(5)|lung(1)|central_nervous_system(1)	14						CTGAGTTGCTGGGGCTTGGCT	0.517			NA											10	47	---	---	---	---	NA	NA	NA	NA	NA
C20orf186	149954	broad.mit.edu	37	20	31671619	31671619	+	Frame_Shift_Del	DEL	G	G	-	rs2424943	byFrequency	TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr20:31671619delG	uc010zue.1	+	3	631	c.616delG	c.(616-618)GGGfs	p.G206fs		NM_182519	NP_872325	P59827	LPLC4_HUMAN	antimicrobial peptide RY2G5 precursor	206	Gly-rich.					cytoplasm|extracellular region	lipid binding				0						TCTTGGAGGAGGGGGTGTCCT	0.652			NA											10	152	---	---	---	---	NA	NA	NA	NA	NA
PXK	54899	broad.mit.edu	37	3	58383335	58383335	+	Frame_Shift_Del	DEL	T	T	-			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr3:58383335delT	uc003djz.1	+	11	1087	c.988delT	c.(988-990)TTGfs	p.L330fs	PXK_uc003djx.1_Frame_Shift_Del_p.L330fs|PXK_uc003djy.1_Frame_Shift_Del_p.L313fs|PXK_uc003dka.1_Frame_Shift_Del_p.L330fs|PXK_uc003dkb.1_Frame_Shift_Del_p.L247fs|PXK_uc003dkc.1_Frame_Shift_Del_p.L313fs|PXK_uc011bfe.1_Frame_Shift_Del_p.L297fs|PXK_uc010hnj.1_Frame_Shift_Del_p.L297fs|PXK_uc003dkd.1_Frame_Shift_Del_p.L193fs|PXK_uc010hnk.1_Frame_Shift_Del_p.L104fs	NM_017771	NP_060241	Q7Z7A4	PXK_HUMAN	PX domain containing serine/threonine kinase	330	Protein kinase.				cell communication|inflammatory response|negative regulation of ATPase activity|negative regulation of ion transport|regulation of synaptic transmission	centrosome|cytoplasm|nucleus|plasma membrane	actin binding|ATP binding|phosphatidylinositol binding|phosphatidylinositol binding|protein C-terminus binding|protein kinase activity			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(55;0.000249)|KIRC - Kidney renal clear cell carcinoma(10;0.00346)|Kidney(10;0.00368)|OV - Ovarian serous cystadenocarcinoma(275;0.22)		TCCACAGACATTGGAAAGTGT	0.547			NA											28	173	---	---	---	---	NA	NA	NA	NA	NA
GPR27	2850	broad.mit.edu	37	3	71804249	71804249	+	Frame_Shift_Del	DEL	G	G	-			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr3:71804249delG	uc011bge.1	+	1	1049	c.1049delG	c.(1048-1050)AGGfs	p.R350fs	EIF4E3_uc003dox.2_5'Flank|EIF4E3_uc011bgd.1_5'Flank|EIF4E3_uc010hoc.2_5'Flank	NM_018971	NP_061844	Q9NS67	GPR27_HUMAN	G protein-coupled receptor 27	350	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(1)	1		Prostate(10;0.00899)		BRCA - Breast invasive adenocarcinoma(55;1.78e-05)|Epithelial(33;5.75e-05)|Lung(16;0.0012)|LUSC - Lung squamous cell carcinoma(21;0.00156)		GACTGCTTCAGGGCCCAGTTC	0.652			NA											7	17	---	---	---	---	NA	NA	NA	NA	NA
VGLL3	389136	broad.mit.edu	37	3	87039828	87039828	+	Frame_Shift_Del	DEL	G	G	-			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr3:87039828delG	uc003dqn.2	-	1	430	c.66delC	c.(64-66)CCCfs	p.P22fs		NM_016206	NP_057290	A8MV65	VGLL3_HUMAN	colon carcinoma related protein	22					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus					0	all_cancers(8;0.109)|Lung SC(3;0.184)	Lung NSC(201;0.0777)		LUSC - Lung squamous cell carcinoma(29;0.00241)|Lung(72;0.00712)		TCGCTGCCATGGGGTTGGGCA	0.657			NA											8	36	---	---	---	---	NA	NA	NA	NA	NA
DBR1	51163	broad.mit.edu	37	3	137880741	137880743	+	In_Frame_Del	DEL	TCG	TCG	-	rs150114751	byFrequency	TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	TCG	TCG	-	-	TCG	TCG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr3:137880741_137880743delTCG	uc003erv.2	-	8	1759_1761	c.1623_1625delCGA	c.(1621-1626)GATGAT>GAT	p.541_542DD>D	DBR1_uc003eru.2_In_Frame_Del_p.490_491DD>D|DBR1_uc003ert.2_In_Frame_Del_p.309_310DD>D	NM_016216	NP_057300	Q9UK59	DBR1_HUMAN	debranching enzyme homolog 1	541_542						nucleus	metal ion binding|RNA lariat debranching enzyme activity				0						TTAAGCTGCATCGTCATCATCAT	0.251			NA											7	222	---	---	---	---	NA	NA	NA	NA	NA
TXK	7294	broad.mit.edu	37	4	48073614	48073614	+	Frame_Shift_Del	DEL	T	T	-			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr4:48073614delT	uc003gxx.3	-	14	1521	c.1435delA	c.(1435-1437)ATTfs	p.I479fs	TXK_uc010igj.2_RNA|TXK_uc011bzj.1_Frame_Shift_Del_p.I166fs	NM_003328	NP_003319	P42681	TXK_HUMAN	TXK tyrosine kinase	479	Protein kinase.					cytoplasm	ATP binding|non-membrane spanning protein tyrosine kinase activity				0						CCTTCAGAAATAGCTTCCACG	0.398			NA											63	182	---	---	---	---	NA	NA	NA	NA	NA
OTUD4	54726	broad.mit.edu	37	4	146059084	146059085	+	Frame_Shift_Ins	INS	-	-	T	rs138021807	by1000genomes	TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr4:146059084_146059085insT	uc003ika.3	-	21	2785_2786	c.2647_2648insA	c.(2647-2649)ACGfs	p.T883fs	OTUD4_uc003ijz.3_Frame_Shift_Ins_p.T882fs	NM_001102653	NP_001096123	Q01804	OTUD4_HUMAN	OTU domain containing 4 protein isoform 3	947							protein binding			ovary(2)|breast(1)	3	all_hematologic(180;0.151)					AGCCAATGCCGTATCTGCCTTT	0.52			NA											33	194	---	---	---	---	NA	NA	NA	NA	NA
ROPN1L	83853	broad.mit.edu	37	5	10442407	10442408	+	Frame_Shift_Ins	INS	-	-	G			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr5:10442407_10442408insG	uc003jex.3	+	1	399_400	c.128_129insG	c.(127-129)GCGfs	p.A43fs		NM_031916	NP_114122	Q96C74	ROP1L_HUMAN	ropporin 1-like	43	RIIa.				ciliary or flagellar motility|signal transduction	cytoplasm|motile cilium	cAMP-dependent protein kinase regulator activity|protein binding			ovary(1)	1						CGGTGGTCCGCGGGGTAAGCGC	0.683			NA											9	67	---	---	---	---	NA	NA	NA	NA	NA
EYS	346007	broad.mit.edu	37	6	66112422	66112422	+	Frame_Shift_Del	DEL	G	G	-			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr6:66112422delG	uc011dxu.1	-	7	1671	c.1133delC	c.(1132-1134)CCTfs	p.P378fs	EYS_uc003peq.2_Frame_Shift_Del_p.P378fs|EYS_uc003per.1_Frame_Shift_Del_p.P378fs	NM_001142800	NP_001136272	Q5T1H1	EYS_HUMAN	eyes shut homolog isoform 1	378	EGF-like 5.				response to stimulus|visual perception	extracellular region	calcium ion binding			lung(4)|ovary(1)|skin(1)	6						ATTCCTCAAAGGAAATGACTC	0.279			NA											7	29	---	---	---	---	NA	NA	NA	NA	NA
ZNF679	168417	broad.mit.edu	37	7	63727024	63727024	+	Frame_Shift_Del	DEL	C	C	-	rs111583875		TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr7:63727024delC	uc003tsx.2	+	5	1282	c.1013delC	c.(1012-1014)ACCfs	p.T338fs		NM_153363	NP_699194	Q8IYX0	ZN679_HUMAN	zinc finger protein 679	338	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1						TGCTCCTCAACCCTTAAGAAA	0.393			NA											7	39	---	---	---	---	NA	NA	NA	NA	NA
AKR1B1	231	broad.mit.edu	37	7	134134483	134134483	+	Frame_Shift_Del	DEL	C	C	-			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr7:134134483delC	uc003vrp.1	-	4	492	c.418delG	c.(418-420)GACfs	p.D140fs	AKR1B1_uc003vrq.1_RNA	NM_001628	NP_001619	P15121	ALDR_HUMAN	aldo-keto reductase family 1, member B1	140					C21-steroid hormone biosynthetic process|carbohydrate metabolic process|response to stress	cytosol|extracellular space|nucleus	alditol:NADP+ 1-oxidoreductase activity|electron carrier activity|protein binding			ovary(3)	3					NADH(DB00157)|Sulindac(DB00605)	GCCCACGTGTCCAGAATGTTG	0.458			NA											9	327	---	---	---	---	NA	NA	NA	NA	NA
DLGAP2	9228	broad.mit.edu	37	8	1616835	1616835	+	Frame_Shift_Del	DEL	C	C	-			TCGA-05-4432-01A-01D-1265-08	TCGA-05-4432-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	377ab4af-0958-4b8b-ac0c-4cd49c1e4c2e	eb55c8bb-5d1b-4274-9e54-adba5cd91626	g.chr8:1616835delC	uc003wpl.2	+	6	2008	c.1911delC	c.(1909-1911)ATCfs	p.I637fs	DLGAP2_uc003wpm.2_Frame_Shift_Del_p.I637fs	NM_004745	NP_004736	Q9P1A6	DLGP2_HUMAN	discs large-associated protein 2	716					neuron-neuron synaptic transmission	cell junction|neurofilament|postsynaptic density|postsynaptic membrane	protein binding				0		Ovarian(12;0.0271)|Hepatocellular(245;0.0838)|Colorectal(14;0.0846)		BRCA - Breast invasive adenocarcinoma(11;0.000169)|READ - Rectum adenocarcinoma(644;0.171)		GCTCCTCCATCGGGATTCAGG	0.632			NA											2	4	---	---	---	---	NA	NA	NA	NA	NA