Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	ACHILLES_Top_Genes	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
HNRNPR	10236	broad.mit.edu	37	1	23648100	23648100	+	Silent	SNP	T	T	A			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr1:23648100T>A	uc001bgr.3	-	7	891	c.732A>T	c.(730-732)GCA>GCT	p.A244A	HNRNPR_uc001bgp.3_Silent_p.A244A|HNRNPR_uc009vqk.2_Silent_p.A143A|HNRNPR_uc001bgs.3_Silent_p.A143A|HNRNPR_uc010odw.1_Silent_p.A206A|HNRNPR_uc010odx.1_Silent_p.A84A|HNRNPR_uc009vql.2_Silent_p.A105A	NM_005826	NP_005817	O43390	HNRPR_HUMAN	heterogeneous nuclear ribonucleoprotein R	244	RRM 1.					catalytic step 2 spliceosome|cytoplasm|heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	nucleotide binding|protein binding|RNA binding			upper_aerodigestive_tract(1)|skin(1)	2		Colorectal(325;3.46e-05)|Lung NSC(340;4.15e-05)|all_lung(284;6.64e-05)|Renal(390;0.000219)|Breast(348;0.00394)|Ovarian(437;0.00539)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;6.83e-27)|Colorectal(126;6.01e-08)|COAD - Colon adenocarcinoma(152;3.32e-06)|GBM - Glioblastoma multiforme(114;6.69e-05)|BRCA - Breast invasive adenocarcinoma(304;0.00101)|KIRC - Kidney renal clear cell carcinoma(1967;0.00357)|STAD - Stomach adenocarcinoma(196;0.0131)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.0875)|LUSC - Lung squamous cell carcinoma(448;0.19)		GTCTGTTGTTTGCCACAGAAA	0.383			NA											46	195					0	0	0.00361	0	0
TCEA3	6920	broad.mit.edu	37	1	23743829	23743829	+	Missense_Mutation	SNP	T	T	A			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr1:23743829T>A	uc001bgx.1	-	4	428	c.293A>T	c.(292-294)AAG>ATG	p.K98M	TCEA3_uc009vqn.1_Missense_Mutation_p.K77M|TCEA3_uc010ody.1_Missense_Mutation_p.K61M	NM_003196	NP_003187	O75764	TCEA3_HUMAN	transcription elongation factor A (SII), 3	98					regulation of transcription elongation, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription elongation, DNA-dependent	nucleus	DNA binding|translation elongation factor activity|zinc ion binding				0		Colorectal(325;3.46e-05)|Lung NSC(340;4.16e-05)|all_lung(284;6.68e-05)|Renal(390;0.000219)|Breast(348;0.00262)|Ovarian(437;0.0054)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;1.6e-25)|Colorectal(126;8.32e-08)|COAD - Colon adenocarcinoma(152;4.29e-06)|GBM - Glioblastoma multiforme(114;9e-05)|BRCA - Breast invasive adenocarcinoma(304;0.00112)|KIRC - Kidney renal clear cell carcinoma(1967;0.00424)|STAD - Stomach adenocarcinoma(196;0.0145)|READ - Rectum adenocarcinoma(331;0.0686)|Lung(427;0.0963)|LUSC - Lung squamous cell carcinoma(448;0.198)		tttttccttcttctttgcctt	0.368			NA											12	119					0	0	0.000978	0	0
CNR2	1269	broad.mit.edu	37	1	24201701	24201701	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr1:24201701C>T	uc001bif.2	-	2	534	c.407G>A	c.(406-408)CGC>CAC	p.R136H		NM_001841	NP_001832	P34972	CNR2_HUMAN	cannabinoid receptor 2 (macrophage)	136	Cytoplasmic (Potential).				behavior|G-protein signaling, coupled to cyclic nucleotide second messenger|immune response|inflammatory response	dendrite|integral to plasma membrane|perikaryon	cannabinoid receptor activity			skin(2)|central_nervous_system(1)	3		Colorectal(325;3.46e-05)|Renal(390;0.000219)|Lung NSC(340;0.000233)|all_lung(284;0.000321)|Ovarian(437;0.00348)|Breast(348;0.00957)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;1.32e-24)|Colorectal(126;6.09e-08)|COAD - Colon adenocarcinoma(152;3.33e-06)|GBM - Glioblastoma multiforme(114;2.9e-05)|BRCA - Breast invasive adenocarcinoma(304;0.00101)|KIRC - Kidney renal clear cell carcinoma(1967;0.00359)|STAD - Stomach adenocarcinoma(196;0.0131)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.146)	Nabilone(DB00486)	AGGTGGATAGCGCAGGCAGAG	0.582			NA											24	122					0	0	0.00632	0	0
CCDC21	64793	broad.mit.edu	37	1	26566285	26566285	+	Missense_Mutation	SNP	A	A	T			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr1:26566285A>T	uc001bls.1	+	2	142	c.11A>T	c.(10-12)CAG>CTG	p.Q4L	CCDC21_uc001blr.2_Missense_Mutation_p.Q4L|CCDC21_uc010ofa.1_Missense_Mutation_p.Q4L	NM_022778	NP_073615	Q6P2H3	CEP85_HUMAN	coiled-coil domain containing 21	4						centrosome|nucleolus|spindle pole					0		all_cancers(24;7e-19)|Colorectal(325;0.000147)|all_lung(284;0.00122)|Lung NSC(340;0.00128)|Renal(390;0.00211)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.051)|Breast(348;0.0589)|all_neural(195;0.0966)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;2.6e-26)|Colorectal(126;1.65e-08)|COAD - Colon adenocarcinoma(152;9.48e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|BRCA - Breast invasive adenocarcinoma(304;0.00105)|STAD - Stomach adenocarcinoma(196;0.00155)|GBM - Glioblastoma multiforme(114;0.00917)|READ - Rectum adenocarcinoma(331;0.0649)		ATGGCCATGCAGGAGAAATAT	0.408			NA											17	81					0	0	0.006122	0	0
WDTC1	23038	broad.mit.edu	37	1	27627736	27627736	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr1:27627736G>T	uc009vst.2	+	13	1787	c.1252G>T	c.(1252-1254)GCC>TCC	p.A418S	WDTC1_uc001bno.2_Missense_Mutation_p.A417S|WDTC1_uc001bnp.1_RNA|WDTC1_uc001bnq.2_Missense_Mutation_p.A96S	NM_015023	NP_055838	Q8N5D0	WDTC1_HUMAN	WD and tetratricopeptide repeats 1	418	TPR 2.						protein binding			ovary(1)|central_nervous_system(1)	2		all_cancers(24;3.12e-19)|all_epithelial(13;4.18e-18)|Colorectal(325;0.000147)|all_lung(284;0.000366)|Lung NSC(340;0.000548)|Renal(390;0.00211)|Breast(348;0.00257)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0707)|all_neural(195;0.0966)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0443)|OV - Ovarian serous cystadenocarcinoma(117;1.09e-27)|Colorectal(126;8.83e-09)|COAD - Colon adenocarcinoma(152;1.02e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000544)|KIRC - Kidney renal clear cell carcinoma(1967;0.00201)|STAD - Stomach adenocarcinoma(196;0.00321)|READ - Rectum adenocarcinoma(331;0.0476)		CCACTATGATGCCCTGAGGGA	0.597			NA									OREG0013280	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	7	54					5.18039e-06	6.61496e-06	0.00308	1	0
RSPO1	284654	broad.mit.edu	37	1	38095323	38095323	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr1:38095323C>A	uc001cbl.1	-	4	799	c.11G>T	c.(10-12)GGG>GTG	p.G4V	RSPO1_uc001cbm.1_Missense_Mutation_p.G4V|RSPO1_uc009vvf.1_Intron|RSPO1_uc009vvg.1_Missense_Mutation_p.G4V	NM_001038633	NP_001033722	Q2MKA7	RSPO1_HUMAN	R-spondin1 precursor	4					positive regulation of canonical Wnt receptor signaling pathway|regulation of receptor internalization		heparin binding				0		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				CACACACAGCCCAAGCCGCAT	0.642	GBM(122;680 2230 27822 42821)		NA											7	28					0.000673444	0.000757396	0.008291	1	0
LRRC41	10489	broad.mit.edu	37	1	46746874	46746874	+	Missense_Mutation	SNP	G	G	T	rs140475848		TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr1:46746874G>T	uc001cpn.2	-	5	1723	c.1679C>A	c.(1678-1680)CCA>CAA	p.P560Q	LRRC41_uc010omb.1_Missense_Mutation_p.P560Q	NM_006369	NP_006360	Q15345	LRC41_HUMAN	MUF1 protein	560										ovary(2)|breast(1)|pancreas(1)	4	Acute lymphoblastic leukemia(166;0.155)					CCGCTGGCTTGGGTGGTCAAC	0.582			NA											6	73					5.4927e-09	7.99815e-09	0.004482	1	0
SLC44A5	204962	broad.mit.edu	37	1	75708683	75708683	+	Missense_Mutation	SNP	T	T	A			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr1:75708683T>A	uc001dgu.2	-	8	503	c.359A>T	c.(358-360)AAG>ATG	p.K120M	SLC44A5_uc001dgt.2_Missense_Mutation_p.K120M|SLC44A5_uc001dgs.2_Missense_Mutation_p.K78M|SLC44A5_uc001dgr.2_Missense_Mutation_p.K78M|SLC44A5_uc010oqz.1_Missense_Mutation_p.K159M|SLC44A5_uc010ora.1_Missense_Mutation_p.K114M|SLC44A5_uc010orb.1_Translation_Start_Site	NM_152697	NP_689910	Q8NCS7	CTL5_HUMAN	solute carrier family 44, member 5 isoform A	120	Extracellular (Potential).					integral to membrane|plasma membrane	choline transmembrane transporter activity			ovary(2)|skin(2)	4						TTCTGGGCACTTGGAGACACA	0.398			NA											24	86					0	0	0.002299	0	0
COL24A1	255631	broad.mit.edu	37	1	86362043	86362043	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr1:86362043G>T	uc001dlj.2	-	29	2870	c.2828C>A	c.(2827-2829)GCC>GAC	p.A943D	COL24A1_uc001dli.2_Missense_Mutation_p.A79D|COL24A1_uc010osd.1_Missense_Mutation_p.A243D|COL24A1_uc001dlk.2_RNA|COL24A1_uc010ose.1_RNA|COL24A1_uc010osf.1_RNA	NM_152890	NP_690850	Q17RW2	COOA1_HUMAN	collagen, type XXIV, alpha 1 precursor	943	Collagen-like 7.				cell adhesion	collagen	extracellular matrix structural constituent			ovary(3)|central_nervous_system(1)|skin(1)	5				all cancers(265;0.0627)|Epithelial(280;0.0689)		GATTACCTTGGCACCTTGTAT	0.313			NA											5	137					0.000602214	0.000679128	0.000602	1	0
VAV3	10451	broad.mit.edu	37	1	108507486	108507486	+	Silent	SNP	C	C	T			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr1:108507486C>T	uc001dvk.1	-	1	60	c.6G>A	c.(4-6)GAG>GAA	p.E2E	VAV3_uc010ouw.1_Silent_p.E2E|VAV3_uc001dvl.1_5'Flank|VAV3_uc010oux.1_Silent_p.E2E	NM_006113	NP_006104	Q9UKW4	VAV3_HUMAN	vav 3 guanine nucleotide exchange factor isoform	2	CH.				angiogenesis|apoptosis|B cell receptor signaling pathway|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of B cell proliferation|regulation of Rho protein signal transduction|response to DNA damage stimulus|response to drug|small GTPase mediated signal transduction	cytosol	GTPase activator activity|metal ion binding|SH3/SH2 adaptor activity			ovary(5)|lung(2)|breast(2)	9		all_epithelial(167;5.38e-05)|all_lung(203;0.000314)|Lung NSC(277;0.000594)		Colorectal(144;0.0331)|Lung(183;0.128)|Epithelial(280;0.204)		GCTTCCACGGCTCCATGCCCG	0.647			NA											3	5					0	0	0.004672	0	0
WARS2	10352	broad.mit.edu	37	1	119576771	119576771	+	Missense_Mutation	SNP	T	T	A			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr1:119576771T>A	uc001ehn.2	-	5	609	c.581A>T	c.(580-582)CAA>CTA	p.Q194L	WARS2_uc010oxf.1_Missense_Mutation_p.Q100L|WARS2_uc001ehm.2_Missense_Mutation_p.Q194L|WARS2_uc010oxg.1_Missense_Mutation_p.Q137L|WARS2_uc010oxh.1_Silent_p.T165T|WARS2_uc010oxi.1_Silent_p.T71T	NM_015836	NP_056651	Q9UGM6	SYWM_HUMAN	mitochondrial tryptophanyl tRNA synthetase 2	194					tryptophanyl-tRNA aminoacylation	mitochondrial matrix	ATP binding|tryptophan-tRNA ligase activity				0	all_neural(166;0.187)	all_lung(203;2.48e-06)|Lung NSC(69;1.74e-05)|all_epithelial(167;0.000564)		Lung(183;0.0629)	L-Tryptophan(DB00150)	GTTGAAACCTTGTGCTAGATC	0.413			NA											16	121					0	0	0.00499	0	0
FLG2	388698	broad.mit.edu	37	1	152326733	152326733	+	Missense_Mutation	SNP	T	T	C			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr1:152326733T>C	uc001ezw.3	-	3	3602	c.3529A>G	c.(3529-3531)ACA>GCA	p.T1177A	uc001ezv.2_Intron	NM_001014342	NP_001014364	Q5D862	FILA2_HUMAN	filaggrin family member 2	1177	Ser-rich.						calcium ion binding|structural molecule activity			ovary(10)|skin(5)|upper_aerodigestive_tract(1)|breast(1)	17	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CCAAAACTTGTGGTTGGACCT	0.483			NA											21	180					0	0	0.010504	0	0
CD1C	911	broad.mit.edu	37	1	158261156	158261156	+	Silent	SNP	G	G	A			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr1:158261156G>A	uc001fru.2	+	2	586	c.294G>A	c.(292-294)GAG>GAA	p.E98E	CD1C_uc001frv.2_5'Flank	NM_001765	NP_001756	P29017	CD1C_HUMAN	CD1C antigen precursor	98	Extracellular (Potential).				antigen processing and presentation|T cell activation involved in immune response	endosome membrane|integral to plasma membrane	endogenous lipid antigen binding|exogenous lipid antigen binding|glycolipid binding|lipopeptide binding			ovary(2)|skin(1)|pancreas(1)	4	all_hematologic(112;0.0378)					TAACTCGGGAGATTCAAGACC	0.368			NA											33	121					0	0	0.004289	0	0
CD1E	913	broad.mit.edu	37	1	158325701	158325701	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr1:158325701C>A	uc001fse.2	+	4	949	c.710C>A	c.(709-711)CCA>CAA	p.P237Q	CD1E_uc010pid.1_Missense_Mutation_p.P235Q|CD1E_uc010pie.1_Missense_Mutation_p.P138Q|CD1E_uc010pif.1_Missense_Mutation_p.P48Q|CD1E_uc001fsd.2_Missense_Mutation_p.P237Q|CD1E_uc001fsk.2_Missense_Mutation_p.P147Q|CD1E_uc001fsj.2_Missense_Mutation_p.P147Q|CD1E_uc001fsc.2_Missense_Mutation_p.P48Q|CD1E_uc010pig.1_RNA|CD1E_uc001fsa.2_Missense_Mutation_p.P48Q|CD1E_uc001fsf.2_Missense_Mutation_p.P237Q|CD1E_uc001fry.2_Missense_Mutation_p.P237Q|CD1E_uc001fsg.2_Missense_Mutation_p.P48Q|CD1E_uc001fsh.2_Missense_Mutation_p.P48Q|CD1E_uc001fsi.2_Missense_Mutation_p.P237Q|CD1E_uc009wsv.2_Missense_Mutation_p.P138Q|CD1E_uc001frz.2_Missense_Mutation_p.P147Q|CD1E_uc009wsw.2_5'UTR	NM_030893	NP_112155	P15812	CD1E_HUMAN	CD1E antigen isoform a precursor	237	Ig-like.				antigen processing and presentation|immune response	early endosome|Golgi membrane|integral to plasma membrane|late endosome|lysosomal lumen				skin(3)	3	all_hematologic(112;0.0378)					GGATTCTACCCAAAGCCCGTG	0.607			NA											27	90					1.55811e-20	2.88668e-20	0.008361	1	0
OR10R2	343406	broad.mit.edu	37	1	158450421	158450421	+	Nonsense_Mutation	SNP	G	G	T			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr1:158450421G>T	uc010pik.1	+	1	754	c.754G>T	c.(754-756)GAG>TAG	p.E252*	uc001fso.1_RNA	NM_001004472	NP_001004472	Q8NGX6	O10R2_HUMAN	olfactory receptor, family 10, subfamily R,	252	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(2)|skin(1)	3	all_hematologic(112;0.0378)					TCCCTCAGCTGAGGGCAGACG	0.453			NA											21	99					1.28384e-07	1.72425e-07	0.001882	1	0
RGS5	8490	broad.mit.edu	37	1	163138072	163138073	+	Missense_Mutation	DNP	GG	GG	TT			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr1:163138072_163138073GG>TT	uc001gcn.2	-	2	377_378	c.130_131CC>AA	c.(130-132)CCA>AAA	p.P44K	RGS5_uc009wvb.2_Intron	NM_003617	NP_003608	O15539	RGS5_HUMAN	regulator of G-protein signalling 5	44					negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway	cytoplasm|plasma membrane	GTPase activator activity|signal transducer activity				0			LUSC - Lung squamous cell carcinoma(543;0.187)			TGGTTTCTCTGGCTTCTCATTG	0.455			NA											29	136					0	0	0.004672	0	0
ILDR2	387597	broad.mit.edu	37	1	166905836	166905836	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr1:166905836G>T	uc001gdx.1	-	5	751	c.695C>A	c.(694-696)CCT>CAT	p.P232H		NM_199351	NP_955383	Q71H61	ILDR2_HUMAN	immunoglobulin-like domain containing receptor	232	Cytoplasmic (Potential).					integral to membrane				ovary(1)	1						ACAGGCTTGAGGGCAGCAGCA	0.602			NA											4	41					0.000442599	0.000501854	0.006214	1	0
GPA33	10223	broad.mit.edu	37	1	167025041	167025041	+	Nonsense_Mutation	SNP	G	G	T			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr1:167025041G>T	uc001gea.1	-	5	961	c.617C>A	c.(616-618)TCG>TAG	p.S206*		NM_005814	NP_005805	Q99795	GPA33_HUMAN	transmembrane glycoprotein A33 precursor	206	Ig-like C2-type.|Extracellular (Potential).					integral to plasma membrane	receptor activity				0						GTAGTAACCCGATGTGTCTGT	0.572			NA											34	107					3.11337e-16	5.49809e-16	0.002836	1	0
PAPPA2	60676	broad.mit.edu	37	1	176668684	176668684	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr1:176668684G>T	uc001gkz.2	+	8	4359	c.3195G>T	c.(3193-3195)TTG>TTT	p.L1065F	PAPPA2_uc009www.2_RNA	NM_020318	NP_064714	Q9BXP8	PAPP2_HUMAN	pappalysin 2 isoform 1	1065					cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			ovary(7)|central_nervous_system(5)|skin(2)|lung(1)|breast(1)	16						CCAGTGGTTTGCCCGTGGTGG	0.567			NA											75	236					4.41824e-40	8.64891e-40	0.00361	1	0
CFHR2	3080	broad.mit.edu	37	1	196928066	196928066	+	Nonsense_Mutation	SNP	G	G	A			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr1:196928066G>A	uc001gtq.1	+	5	746	c.669G>A	c.(667-669)TGG>TGA	p.W223*	CFHR2_uc001gtr.1_Nonsense_Mutation_p.W99*	NM_005666	NP_005657	P36980	FHR2_HUMAN	H factor (complement)-like 3 precursor	223	Sushi 4.					extracellular region				skin(2)|ovary(1)	3						AATTAAAGTGGACAAACCAAC	0.279			NA											3	37					0	0	0.000602	0	0
USH2A	7399	broad.mit.edu	37	1	216019167	216019167	+	Silent	SNP	C	C	A			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr1:216019167C>A	uc001hku.1	-	45	9441	c.9054G>T	c.(9052-9054)GGG>GGT	p.G3018G		NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	3018	Extracellular (Potential).				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		TGGACTCACCCCCATCGCAAG	0.438			NA								HNSCC(13;0.011)			7	46					5.18039e-06	6.61496e-06	0.00308	1	0
HHIPL2	79802	broad.mit.edu	37	1	222717100	222717100	+	Silent	SNP	C	C	G			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr1:222717100C>G	uc001hnh.1	-	2	811	c.753G>C	c.(751-753)CTG>CTC	p.L251L		NM_024746	NP_079022	Q6UWX4	HIPL2_HUMAN	HHIP-like 2 precursor	251					carbohydrate metabolic process	extracellular region	oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor|quinone binding			ovary(1)	1				GBM - Glioblastoma multiforme(131;0.0185)		AGGGTTGCTCCAGGCGACTCC	0.592			NA											30	158					0	0	0.007291	0	0
ITPKB	3707	broad.mit.edu	37	1	226836376	226836376	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr1:226836376C>T	uc010pvo.1	-	3	2369	c.2029G>A	c.(2029-2031)GCA>ACA	p.A677T		NM_002221	NP_002212	P27987	IP3KB_HUMAN	1D-myo-inositol-trisphosphate 3-kinase B	677							ATP binding|calmodulin binding|inositol trisphosphate 3-kinase activity			ovary(4)|central_nervous_system(1)	5		Prostate(94;0.0773)				TGTCTACCTGCGTGTCCTGCC	0.547	Colon(84;110 1851 5306 33547)		NA											10	173					0	0	0.008291	0	0
PRSS38	339501	broad.mit.edu	37	1	228033666	228033666	+	Silent	SNP	G	G	C			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr1:228033666G>C	uc001hrh.2	+	5	738	c.738G>C	c.(736-738)GGG>GGC	p.G246G		NM_183062	NP_898885	A1L453	PRS38_HUMAN	marapsin 2 precursor	246	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			ovary(1)|pancreas(1)	2						GCGACTCCGGGGGCCCACTTG	0.607			NA											13	62					0	0	0.003163	0	0
RYR2	6262	broad.mit.edu	37	1	237948095	237948095	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr1:237948095G>T	uc001hyl.1	+	90	13203	c.13083G>T	c.(13081-13083)GAG>GAT	p.E4361D	RYR2_uc010pya.1_Missense_Mutation_p.E776D	NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	4361					cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			TGCCCTCCGAGGATCTGACCG	0.537			NA											18	96					4.96729e-08	6.84859e-08	0.008871	1	0
OR1C1	26188	broad.mit.edu	37	1	247921322	247921322	+	Silent	SNP	G	G	A			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr1:247921322G>A	uc010pza.1	-	1	387	c.387C>T	c.(385-387)CCC>CCT	p.P129P		NM_012353	NP_036485	Q15619	OR1C1_HUMAN	olfactory receptor, family 1, subfamily C,	129	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	all_cancers(71;4.34e-05)|all_epithelial(71;1.13e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0786)|Lung NSC(105;0.0858)	all_cancers(173;0.0247)	OV - Ovarian serous cystadenocarcinoma(106;0.0168)			TGTAATGTAAGGGGTGGCAAA	0.502			NA											11	65					0	0	0.000978	0	0
OR2T8	343172	broad.mit.edu	37	1	248084558	248084558	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr1:248084558C>G	uc010pzc.1	+	1	239	c.239C>G	c.(238-240)GCG>GGG	p.A80G		NM_001005522	NP_001005522	A6NH00	OR2T8_HUMAN	olfactory receptor, family 2, subfamily T,	80	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)	all_cancers(173;0.0211)	OV - Ovarian serous cystadenocarcinoma(106;0.0319)			CCCAAAATGGCGGCTGACTAC	0.577			NA											4	171					0	0	0.00308	0	0
OR2M5	127059	broad.mit.edu	37	1	248309050	248309050	+	Missense_Mutation	SNP	A	A	T			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr1:248309050A>T	uc010pze.1	+	1	601	c.601A>T	c.(601-603)ATC>TTC	p.I201F		NM_001004690	NP_001004690	A3KFT3	OR2M5_HUMAN	olfactory receptor, family 2, subfamily M,	201	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|kidney(1)	3	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0388)			GGTTCTTTTCATCTGCTGTAT	0.433			NA											12	402					0	0	0.001368	0	0
OR2G6	391211	broad.mit.edu	37	1	248685264	248685264	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr1:248685264G>T	uc001ien.1	+	1	317	c.317G>T	c.(316-318)GGG>GTG	p.G106V		NM_001013355	NP_001013373	Q5TZ20	OR2G6_HUMAN	olfactory receptor, family 2, subfamily G,	106	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)	all_cancers(173;0.0156)	OV - Ovarian serous cystadenocarcinoma(106;0.0265)			GTGGCCATGGGGTTGGGCTCG	0.542			NA											8	140					5.18039e-06	6.61496e-06	0.00308	1	0
SH3BP5L	80851	broad.mit.edu	37	1	249110823	249110823	+	Silent	SNP	C	C	A			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr1:249110823C>A	uc001iew.1	-	4	837	c.285G>T	c.(283-285)TCG>TCT	p.S95S	SH3BP5L_uc010pzp.1_5'Flank|SH3BP5L_uc010pzq.1_Silent_p.S63S|SH3BP5L_uc001iev.1_5'UTR	NM_030645	NP_085148	Q7L8J4	3BP5L_HUMAN	SH3-binding domain protein 5-like	95	Potential.										0	all_cancers(71;3.33e-06)|all_epithelial(71;2.41e-06)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.0458)|Lung NSC(105;0.0494)|Melanoma(84;0.199)	all_cancers(173;0.19)	OV - Ovarian serous cystadenocarcinoma(106;0.00805)			GTTTCCTCGCCGACTCCTGTA	0.582			NA											11	161					1.58986e-06	2.08137e-06	0.008291	1	0
C10orf140	387640	broad.mit.edu	37	10	21804176	21804176	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr10:21804176C>A	uc009xkd.2	-	4	4829	c.2576G>T	c.(2575-2577)GGG>GTG	p.G859V	uc001iqp.1_Intron	NM_207371	NP_997254	Q1XH10	DLN1_HUMAN	hypothetical protein LOC387640	778						nucleus	nucleotide binding			ovary(1)	1						CCCATCTCTCCCAATAATGAG	0.458			NA											15	43					0.000422831	0.000484738	0.004007	1	0
FAM13C	220965	broad.mit.edu	37	10	61112108	61112108	+	Silent	SNP	G	G	C			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr10:61112108G>C	uc001jkn.2	-	4	380	c.246C>G	c.(244-246)CCC>CCG	p.P82P	FAM13C_uc001jko.2_Silent_p.P82P|FAM13C_uc010qid.1_5'UTR|FAM13C_uc010qie.1_5'UTR|FAM13C_uc010qif.1_Silent_p.P104P|FAM13C_uc001jkp.2_5'UTR	NM_198215	NP_937858	Q8NE31	FA13C_HUMAN	hypothetical protein LOC220965 isoform 1	82										ovary(2)	2						TGCCCATGCTGGGTCGCAATA	0.612			NA											10	78					0	0	0.008291	0	0
TET1	80312	broad.mit.edu	37	10	70404986	70404986	+	Missense_Mutation	SNP	T	T	G			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr10:70404986T>G	uc001jok.3	+	4	3005	c.2500T>G	c.(2500-2502)TCC>GCC	p.S834A		NM_030625	NP_085128	Q8NFU7	TET1_HUMAN	CXXC finger 6	834					DNA demethylation|inner cell mass cell differentiation|negative regulation of methylation-dependent chromatin silencing|stem cell maintenance		iron ion binding|methylcytosine dioxygenase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|structure-specific DNA binding|zinc ion binding			ovary(5)|lung(2)|prostate(1)|breast(1)	9						TAACTGCAGTTCCATTCCACA	0.393			NA											20	299					0	0	0.001882	0	0
TSPAN15	23555	broad.mit.edu	37	10	71265915	71265915	+	Silent	SNP	C	C	A			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr10:71265915C>A	uc001jpo.1	+	7	779	c.654C>A	c.(652-654)GGC>GGA	p.G218G		NM_012339	NP_036471	O95858	TSN15_HUMAN	transmembrane 4 superfamily member 15	218	Extracellular (Potential).					integral to plasma membrane|membrane fraction					0						ACGTGCGGGGCTGCACCAACG	0.597			NA											12	126					0.000151284	0.00017938	0.001855	1	0
FUT11	170384	broad.mit.edu	37	10	75532609	75532609	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr10:75532609G>A	uc001jva.2	+	1	561	c.518G>A	c.(517-519)CGC>CAC	p.R173H	FUT11_uc001juy.1_Missense_Mutation_p.R173H|FUT11_uc001juz.1_Missense_Mutation_p.R173H	NM_173540	NP_775811	Q495W5	FUT11_HUMAN	fucosyltransferase 11 (alpha (1,3)	173	Lumenal (Potential).				protein glycosylation	Golgi cisterna membrane|integral to membrane	alpha(1,3)-fucosyltransferase activity				0	Prostate(51;0.0112)					ACCTTCAGTCGCCACTCGGAT	0.687			NA											15	35					0	0	0.007413	0	0
MYST4	23522	broad.mit.edu	37	10	76781967	76781967	+	Missense_Mutation	SNP	A	A	T			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr10:76781967A>T	uc001jwn.1	+	16	3843	c.3350A>T	c.(3349-3351)CAG>CTG	p.Q1117L	MYST4_uc001jwm.1_Missense_Mutation_p.Q825L|MYST4_uc001jwo.1_Missense_Mutation_p.Q825L|MYST4_uc001jwp.1_Missense_Mutation_p.Q934L	NM_012330	NP_036462	Q8WYB5	MYST4_HUMAN	MYST histone acetyltransferase (monocytic	1117					histone H3 acetylation|negative regulation of transcription, DNA-dependent|nucleosome assembly|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	MOZ/MORF histone acetyltransferase complex|nucleosome	DNA binding|histone acetyltransferase activity|transcription factor binding|zinc ion binding			central_nervous_system(5)|ovary(4)|lung(3)|breast(2)|skin(1)|prostate(1)	16	all_cancers(46;0.0347)|all_epithelial(25;0.00236)|Prostate(51;0.0112)|Ovarian(15;0.0964)					ACGAAACCACAGTCAGTTGCC	0.264			NA	T	CREBBP	AML						OREG0020273	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	35	188					0	0	0.00874	0	0
CDHR1	92211	broad.mit.edu	37	10	85973997	85973997	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr10:85973997C>A	uc001kcv.2	+	17	2200	c.2200C>A	c.(2200-2202)CTG>ATG	p.L734M	CDHR1_uc001kcw.2_Intron|CDHR1_uc009xst.2_Missense_Mutation_p.L438M|CDHR1_uc001kcx.2_Missense_Mutation_p.L48M	NM_033100	NP_149091	Q96JP9	CDHR1_HUMAN	protocadherin 21 precursor	734	Cytoplasmic (Potential).				homophilic cell adhesion		calcium ion binding|receptor activity			ovary(1)	1						TAACAAGGTCCTGCCAATGCG	0.642			NA											12	63					5.03518e-11	7.97558e-11	0.007413	1	0
GRID1	2894	broad.mit.edu	37	10	87373323	87373323	+	Silent	SNP	G	G	T			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr10:87373323G>T	uc001kdl.1	-	15	2543	c.2442C>A	c.(2440-2442)ACC>ACA	p.T814T	GRID1_uc009xsu.1_RNA|GRID1_uc010qmf.1_Silent_p.T385T	NM_017551	NP_060021	Q9ULK0	GRID1_HUMAN	glutamate receptor, ionotropic, delta 1	814	Extracellular (Potential).					cell junction|integral to membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			ovary(5)|upper_aerodigestive_tract(2)|large_intestine(2)|central_nervous_system(1)	10					L-Glutamic Acid(DB00142)	TGGCATGGCTGGTGAGGTCAC	0.632			NA								Multiple Myeloma(13;0.14)			16	58					6.33239e-15	1.09498e-14	0.010504	1	0
BTAF1	9044	broad.mit.edu	37	10	93749274	93749274	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr10:93749274C>G	uc001khr.2	+	20	2889	c.2791C>G	c.(2791-2793)CCA>GCA	p.P931A	BTAF1_uc001khs.1_Missense_Mutation_p.P601A|BTAF1_uc001kht.1_Missense_Mutation_p.P369A	NM_003972	NP_003963	O14981	BTAF1_HUMAN	BTAF1 RNA polymerase II, B-TFIID transcription	931					negative regulation of transcription, DNA-dependent	nucleus	ATP binding|DNA binding|helicase activity|sequence-specific DNA binding transcription factor activity			ovary(1)|central_nervous_system(1)|skin(1)	3		Colorectal(252;0.0846)				TTGTGTGGACCCATATCTAAC	0.403			NA											9	98					0	0	0.006214	0	0
CYP2C19	1557	broad.mit.edu	37	10	96534881	96534881	+	Nonsense_Mutation	SNP	G	G	T			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr10:96534881G>T	uc010qnz.1	+	2	235	c.235G>T	c.(235-237)GGA>TGA	p.G79*	CYP2C19_uc009xus.1_Intron|CYP2C19_uc010qny.1_Nonsense_Mutation_p.G57*	NM_000769	NP_000760	P33261	CP2CJ_HUMAN	cytochrome P450, family 2, subfamily C,	79					exogenous drug catabolic process|heterocycle metabolic process|monoterpenoid metabolic process|steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	(S)-limonene 6-monooxygenase activity|(S)-limonene 7-monooxygenase activity|4-hydroxyacetophenone monooxygenase activity|electron carrier activity|enzyme binding|heme binding|oxygen binding|steroid hydroxylase activity			ovary(4)|central_nervous_system(1)|skin(1)	6		Colorectal(252;0.09)		all cancers(201;6.02e-07)|KIRC - Kidney renal clear cell carcinoma(50;0.0672)|Kidney(138;0.0838)	Adinazolam(DB00546)|Aminophenazone(DB01424)|Amitriptyline(DB00321)|Amoxicillin(DB01060)|Arformoterol(DB01274)|Bortezomib(DB00188)|Carisoprodol(DB00395)|Chlorzoxazone(DB00356)|Cilostazol(DB01166)|Citalopram(DB00215)|Clarithromycin(DB01211)|Clobazam(DB00349)|Desipramine(DB01151)|Desloratadine(DB00967)|Diclofenac(DB00586)|Diltiazem(DB00343)|Efavirenz(DB00625)|Esomeprazole(DB00736)|Famotidine(DB00927)|Felbamate(DB00949)|Finasteride(DB01216)|Flunitrazepam(DB01544)|Fluvoxamine(DB00176)|Formoterol(DB00983)|Fosphenytoin(DB01320)|Guanfacine(DB01018)|Imipramine(DB00458)|Indomethacin(DB00328)|Ketoconazole(DB01026)|Lansoprazole(DB00448)|Lapatinib(DB01259)|Loratadine(DB00455)|Melatonin(DB01065)|Mephenytoin(DB00532)|Methadone(DB00333)|Methylphenobarbital(DB00849)|Moclobemide(DB01171)|Modafinil(DB00745)|Nelfinavir(DB00220)|Nicardipine(DB00622)|Nilutamide(DB00665)|Norgestrel(DB00506)|Omeprazole(DB00338)|Oxcarbazepine(DB00776)|Pantoprazole(DB00213)|Pentamidine(DB00738)|Phenobarbital(DB01174)|Phenytoin(DB00252)|Primidone(DB00794)|Progesterone(DB00396)|Proguanil(DB01131)|Promazine(DB00420)|Quinidine(DB00908)|Rabeprazole(DB01129)|Ranitidine(DB00863)|Ritonavir(DB00503)|Selegiline(DB01037)|Sertraline(DB01104)|Temazepam(DB00231)|Teniposide(DB00444)|Terfenadine(DB00342)|Thalidomide(DB01041)|Thioridazine(DB00679)|Ticlopidine(DB00208)|Tolbutamide(DB01124)|Topiramate(DB00273)|Tranylcypromine(DB00752)|Troglitazone(DB00197)|Troleandomycin(DB01361)|Voriconazole(DB00582)	GGTGCTGCATGGATATGAAGT	0.458			NA											29	123					3.80469e-20	7.01755e-20	0.009535	1	0
OR51F2	119694	broad.mit.edu	37	11	4843600	4843600	+	Missense_Mutation	SNP	A	A	T			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr11:4843600A>T	uc010qyn.1	+	1	985	c.985A>T	c.(985-987)AAT>TAT	p.N329Y		NM_001004753	NP_001004753	Q8NH61	O51F2_HUMAN	olfactory receptor, family 51, subfamily F,	329	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|pancreas(1)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.0778)		Epithelial(150;5.06e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00438)|LUSC - Lung squamous cell carcinoma(625;0.19)		CTCCAAATCTAATCATCAGCT	0.383			NA											13	56					0	0	0.001368	0	0
OR51L1	119682	broad.mit.edu	37	11	5020470	5020470	+	Silent	SNP	G	G	T			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr11:5020470G>T	uc010qyu.1	+	1	258	c.258G>T	c.(256-258)GTG>GTT	p.V86V		NM_001004755	NP_001004755	Q8NGJ5	O51L1_HUMAN	olfactory receptor, family 51, subfamily L,	86	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1		Medulloblastoma(188;0.0061)|all_neural(188;0.0479)|Breast(177;0.086)		Epithelial(150;1.75e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0285)|LUSC - Lung squamous cell carcinoma(625;0.19)		TGCTTGCTGTGTTATGGTTGG	0.483			NA											8	175					0.000442599	0.000501854	0.006214	1	0
OR51V1	283111	broad.mit.edu	37	11	5221508	5221508	+	Silent	SNP	A	A	G			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr11:5221508A>G	uc010qyz.1	-	1	423	c.423T>C	c.(421-423)TAT>TAC	p.Y141Y		NM_001004760	NP_001004760	Q9H2C8	O51V1_HUMAN	olfactory receptor, family 51, subfamily V,	141	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;2.83e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GGATGGAGGAATAACGTAGTG	0.418			NA											7	76					0	0	0.004482	0	0
TUB	7275	broad.mit.edu	37	11	8118969	8118969	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr11:8118969G>T	uc001mga.2	+	7	1031	c.882G>T	c.(880-882)AAG>AAT	p.K294N	TUB_uc010rbk.1_Missense_Mutation_p.K300N|TUB_uc001mfy.2_Missense_Mutation_p.K349N	NM_177972	NP_813977	P50607	TUB_HUMAN	tubby isoform b	294					phagocytosis|positive regulation of phagocytosis|response to stimulus	cytoplasm|extracellular region|nucleus|plasma membrane				ovary(1)	1		all_lung(207;6.91e-20)|Lung NSC(207;3.36e-17)		Epithelial(150;1.69e-62)|BRCA - Breast invasive adenocarcinoma(625;8.54e-06)|LUSC - Lung squamous cell carcinoma(625;0.000184)		AGGATGGGAAGAAGGTAAGGT	0.512			NA											13	106					4.93089e-13	8.21815e-13	0.00245	1	0
ABCC8	6833	broad.mit.edu	37	11	17419905	17419905	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr11:17419905C>G	uc001mnc.2	-	30	3860	c.3734G>C	c.(3733-3735)AGA>ACA	p.R1245T		NM_000352	NP_000343	Q09428	ABCC8_HUMAN	ATP-binding cassette, sub-family C, member 8	1245	ABC transmembrane type-1 2.|Cytoplasmic (By similarity).				carbohydrate metabolic process|energy reserve metabolic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium ion transmembrane transporter activity|sulfonylurea receptor activity			ovary(1)	1				READ - Rectum adenocarcinoma(2;0.0325)|Colorectal(2;0.1)	Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)|Gliclazide(DB01120)|Mitiglinide(DB01252)|Nateglinide(DB00731)|Repaglinide(DB00912)	TTCCAGCCATCTGTTGGCAGC	0.552			NA											7	56					0	0	0.006214	0	0
OR4C15	81309	broad.mit.edu	37	11	55322475	55322475	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr11:55322475G>C	uc010rig.1	+	1	693	c.693G>C	c.(691-693)ATG>ATC	p.M231I		NM_001001920	NP_001001920	Q8NGM1	OR4CF_HUMAN	olfactory receptor, family 4, subfamily C,	177	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						ATCACTTTATGTGTGACTTGT	0.463			NA								HNSCC(20;0.049)			14	61					0	0	0.00245	0	0
OR8I2	120586	broad.mit.edu	37	11	55860901	55860901	+	Silent	SNP	T	T	C			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr11:55860901T>C	uc010rix.1	+	1	118	c.118T>C	c.(118-120)TTG>CTG	p.L40L		NM_001003750	NP_001003750	Q8N0Y5	OR8I2_HUMAN	olfactory receptor, family 8, subfamily I,	40	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)	1	Esophageal squamous(21;0.00693)					ATTCACTGTTTTGGGAAACCT	0.378			NA											34	201					0	0	0.004289	0	0
CTNND1	1500	broad.mit.edu	37	11	57563083	57563083	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr11:57563083G>C	uc001nmc.3	+	5	873	c.302G>C	c.(301-303)AGG>ACG	p.R101T	CTNND1_uc001nlf.1_Missense_Mutation_p.R101T|CTNND1_uc001nlh.1_Missense_Mutation_p.R101T|CTNND1_uc001nlu.3_5'UTR|CTNND1_uc001nlt.3_5'UTR|CTNND1_uc001nls.3_5'UTR|CTNND1_uc001nlw.3_5'UTR|CTNND1_uc001nmf.3_Missense_Mutation_p.R101T|CTNND1_uc001nmd.3_Missense_Mutation_p.R47T|CTNND1_uc001nlk.3_Missense_Mutation_p.R47T|CTNND1_uc001nme.3_Missense_Mutation_p.R101T|CTNND1_uc001nll.3_Missense_Mutation_p.R47T|CTNND1_uc001nmg.3_Missense_Mutation_p.R47T|CTNND1_uc001nlj.3_Missense_Mutation_p.R47T|CTNND1_uc001nlr.3_Missense_Mutation_p.R47T|CTNND1_uc001nlp.3_Missense_Mutation_p.R47T|CTNND1_uc001nlx.3_Intron|CTNND1_uc001nlz.3_Intron|CTNND1_uc009ymn.2_Intron|CTNND1_uc001nlm.3_Missense_Mutation_p.R101T|CTNND1_uc001nly.3_Intron|CTNND1_uc001nmb.3_Intron|CTNND1_uc001nma.3_Intron|CTNND1_uc001nmi.3_5'UTR|CTNND1_uc001nmh.3_Missense_Mutation_p.R101T|CTNND1_uc001nlq.3_5'UTR|CTNND1_uc001nln.3_Missense_Mutation_p.R101T|CTNND1_uc001nli.3_Missense_Mutation_p.R101T|CTNND1_uc001nlo.3_5'UTR|CTNND1_uc001nlv.3_5'UTR	NM_001085458	NP_001078927	O60716	CTND1_HUMAN	catenin, delta 1 isoform 1ABC	101					adherens junction organization|cell junction assembly|negative regulation of canonical Wnt receptor signaling pathway|regulation of transcription, DNA-dependent|transcription, DNA-dependent|Wnt receptor signaling pathway	cytosol|midbody|nucleus	cadherin binding|protein binding|receptor binding			breast(4)|ovary(1)|kidney(1)	6		all_epithelial(135;0.155)				ACCATCCCCAGGATGCAGGAG	0.473			NA											3	40					0	0	0.004672	0	0
OR5AN1	390195	broad.mit.edu	37	11	59132051	59132051	+	Silent	SNP	G	G	T			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr11:59132051G>T	uc010rks.1	+	1	120	c.120G>T	c.(118-120)CTG>CTT	p.L40L		NM_001004729	NP_001004729	Q8NGI8	O5AN1_HUMAN	olfactory receptor, family 5, subfamily AN,	40	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						TTACATCTCTGGCCTGGAACC	0.418			NA											19	270					5.35267e-07	7.09699e-07	0.007413	1	0
OR4D10	390197	broad.mit.edu	37	11	59245669	59245669	+	Missense_Mutation	SNP	A	A	G			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr11:59245669A>G	uc001nnz.1	+	1	767	c.767A>G	c.(766-768)TAT>TGT	p.Y256C		NM_001004705	NP_001004705	Q8NGI6	OR4DA_HUMAN	olfactory receptor, family 4, subfamily D,	256	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3						CCCTGCATCTATGTCTATGCC	0.562			NA											26	225					0	0	0.007291	0	0
AHNAK	79026	broad.mit.edu	37	11	62290909	62290909	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr11:62290909C>A	uc001ntl.2	-	5	11280	c.10980G>T	c.(10978-10980)AAG>AAT	p.K3660N	AHNAK_uc001ntk.1_Intron	NM_001620	NP_001611	Q09666	AHNK_HUMAN	AHNAK nucleoprotein isoform 1	3660					nervous system development	nucleus	protein binding			ovary(10)|pancreas(4)|skin(4)|upper_aerodigestive_tract(1)	19		Melanoma(852;0.155)				TCTCAGGCATCTTGAACTTGG	0.468			NA											41	418					2.54651e-27	4.91535e-27	0.006999	1	0
MYEOV	26579	broad.mit.edu	37	11	69062910	69062910	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr11:69062910C>T	uc001oov.2	+	2	539	c.89C>T	c.(88-90)TCC>TTC	p.S30F	MYEOV_uc001oox.2_Intron|MYEOV_uc009ysl.2_Missense_Mutation_p.S30F|MYEOV_uc001oow.2_5'UTR	NM_138768	NP_620123	Q96EZ4	MYEOV_HUMAN	myeloma overexpressed	30											0	all_lung(4;2.21e-19)|Lung NSC(4;6.13e-19)|Melanoma(5;0.00128)		LUSC - Lung squamous cell carcinoma(11;3.33e-11)|STAD - Stomach adenocarcinoma(18;0.00654)|LUAD - Lung adenocarcinoma(13;0.0713)	Kidney(183;2.99e-09)|KIRC - Kidney renal clear cell carcinoma(183;3.23e-08)|Lung(977;0.00361)|LUSC - Lung squamous cell carcinoma(976;0.0153)		cagtctccctcctggtgtcAT	0.264			NA											20	84					0	0	0.010504	0	0
FAT3	120114	broad.mit.edu	37	11	92525961	92525961	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr11:92525961G>T	uc001pdj.3	+	8	4657	c.4640G>T	c.(4639-4641)AGA>ATA	p.R1547I		NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	1547	Cadherin 14.|Extracellular (Potential).				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				CCTTATCGAAGAAACTTGGCC	0.368			NA								TCGA Ovarian(4;0.039)			9	149					1.58986e-06	2.08137e-06	0.008291	1	0
FAT3	120114	broad.mit.edu	37	11	92535011	92535011	+	Silent	SNP	C	C	A			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr11:92535011C>A	uc001pdj.3	+	9	8849	c.8832C>A	c.(8830-8832)GCC>GCA	p.A2944A		NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	2944	Cadherin 27.|Extracellular (Potential).				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				AGGTGGTAGCCGTCCTCAGCA	0.517			NA								TCGA Ovarian(4;0.039)			12	112					7.03913e-09	1.01432e-08	0.001368	1	0
NPAT	4863	broad.mit.edu	37	11	108057265	108057265	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr11:108057265C>T	uc001pjz.3	-	8	772	c.670G>A	c.(670-672)GGC>AGC	p.G224S	NPAT_uc001pka.2_Missense_Mutation_p.G19S	NM_002519	NP_002510	Q14207	NPAT_HUMAN	nuclear protein,  ataxia-telangiectasia locus	224	Interaction with MIZF.				positive regulation of transcription, DNA-dependent|regulation of transcription involved in G1/S phase of mitotic cell cycle	Cajal body	protein C-terminus binding|protein N-terminus binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity			ovary(2)	2		all_cancers(61;2.31e-10)|all_epithelial(67;1.11e-06)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		BRCA - Breast invasive adenocarcinoma(274;1.05e-05)|Epithelial(105;3.01e-05)|all cancers(92;0.000816)|Colorectal(284;0.116)		GAATGAGGGCCAGACAAAGTG	0.323			NA											8	92					0	0	0.008291	0	0
DSCAML1	57453	broad.mit.edu	37	11	117395626	117395626	+	Silent	SNP	T	T	C			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr11:117395626T>C	uc001prh.1	-	5	1013	c.1011A>G	c.(1009-1011)ACA>ACG	p.T337T	DSCAML1_uc001pri.1_Silent_p.T141T	NM_020693	NP_065744	Q8TD84	DSCL1_HUMAN	Down syndrome cell adhesion molecule like 1	277	Ig-like C2-type 3.|Extracellular (Potential).				axonogenesis|brain development|cell fate determination|dorsal/ventral pattern formation|embryonic skeletal system morphogenesis|homophilic cell adhesion	cell surface|integral to membrane|plasma membrane	protein homodimerization activity			ovary(3)|large_intestine(2)|skin(2)|upper_aerodigestive_tract(1)	8	all_hematologic(175;0.0487)	Breast(348;0.0424)|Medulloblastoma(222;0.0523)|all_hematologic(192;0.232)		BRCA - Breast invasive adenocarcinoma(274;9.12e-06)|Epithelial(105;0.00172)		TGGTCAGCCCTGTGATGCGCT	0.657			NA											3	22					0	0	0.000602	0	0
OR8D1	283159	broad.mit.edu	37	11	124180365	124180365	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr11:124180365G>T	uc010sag.1	-	1	298	c.298C>A	c.(298-300)CAG>AAG	p.Q100K		NM_001002917	NP_001002917	Q8WZ84	OR8D1_HUMAN	olfactory receptor, family 8, subfamily D,	100	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0528)		AAAAAGAGCTGGACCATGCAC	0.453			NA											3	27					2.56e-06	3.33041e-06	0.009096	1	0
PRDM10	56980	broad.mit.edu	37	11	129801996	129801996	+	Splice_Site	SNP	C	C	A			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr11:129801996C>A	uc001qfm.2	-	10	1519	c.1287_splice	c.e10+1	p.Q429_splice	PRDM10_uc001qfj.2_Splice_Site_p.Q343_splice|PRDM10_uc001qfk.2_Splice_Site_p.Q343_splice|PRDM10_uc001qfl.2_Splice_Site_p.Q343_splice|PRDM10_uc010sbx.1_Splice_Site_p.Q343_splice|PRDM10_uc001qfn.2_Splice_Site_p.Q429_splice|PRDM10_uc009zct.1_Splice_Site_p.Q461_splice	NM_020228	NP_064613	Q9NQV6	PRD10_HUMAN	PR domain containing 10 isoform 1						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			pancreas(1)	1	all_hematologic(175;0.0537)	Breast(109;0.000496)|Lung NSC(97;0.000693)|all_lung(97;0.00151)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.0174)|Lung(977;0.176)|LUSC - Lung squamous cell carcinoma(976;0.185)		TCCCCCCGTACCTGTGTCCCA	0.562			NA											17	100					1.33834e-09	1.99788e-09	0.007413	1	0
ERC1	23085	broad.mit.edu	37	12	1299084	1299084	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr12:1299084C>A	uc001qjb.2	+	12	2458	c.2217C>A	c.(2215-2217)CAC>CAA	p.H739Q	ERC1_uc001qiz.2_RNA|ERC1_uc001qjc.2_Missense_Mutation_p.H711Q|ERC1_uc001qja.2_RNA|ERC1_uc001qjd.2_RNA|ERC1_uc001qjf.2_Missense_Mutation_p.H739Q|ERC1_uc010sdv.1_Missense_Mutation_p.H487Q|ERC1_uc009zdp.2_Missense_Mutation_p.H379Q|ERC1_uc001qje.2_RNA	NM_178040	NP_829884	Q8IUD2	RB6I2_HUMAN	RAB6-interacting protein 2 isoform epsilon	739	Potential.				I-kappaB phosphorylation|multicellular organismal development|positive regulation of anti-apoptosis|positive regulation of NF-kappaB transcription factor activity|protein transport	Golgi membrane|IkappaB kinase complex|presynaptic membrane	leucine zipper domain binding			ovary(2)|lung(2)|breast(1)	5	all_epithelial(11;0.0698)|Ovarian(42;0.107)		OV - Ovarian serous cystadenocarcinoma(31;0.00239)|BRCA - Breast invasive adenocarcinoma(9;0.0567)			GAATACAGCACTTGGAGAGAG	0.458			NA											12	62					2.61681e-11	4.17684e-11	0.00245	1	0
ANO2	57101	broad.mit.edu	37	12	5687595	5687595	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr12:5687595G>T	uc001qnm.2	-	22	2395	c.2323C>A	c.(2323-2325)CTC>ATC	p.L775I		NM_020373	NP_065106	Q9NQ90	ANO2_HUMAN	anoctamin 2	780	Cytoplasmic (Potential).					chloride channel complex|plasma membrane	intracellular calcium activated chloride channel activity			ovary(4)|large_intestine(2)|central_nervous_system(1)	7						TTTGCATCGAGCCGCACTTCA	0.547			NA											5	52					1.26484e-09	1.89498e-09	0.00308	1	0
TMTC1	83857	broad.mit.edu	37	12	29911688	29911688	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr12:29911688G>T	uc001rjb.2	-	3	653	c.179C>A	c.(178-180)GCG>GAG	p.A60E	TMTC1_uc001rjc.1_Missense_Mutation_p.A60E	NM_175861	NP_787057	Q8IUR5	TMTC1_HUMAN	transmembrane and tetratricopeptide repeat	168	Helical; (Potential).					integral to membrane	binding				0	Lung NSC(12;7.61e-10)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.032)					TAACACGTCCGCTCTGCCAAC	0.413			NA											4	17					0.000602214	0.000679128	0.000602	1	0
MLL2	8085	broad.mit.edu	37	12	49435239	49435239	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr12:49435239C>T	uc001rta.3	-	31	6314	c.6314G>A	c.(6313-6315)CGC>CAC	p.R2105H		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	2105					chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						CGGGGGAATGCGGAGATGTAG	0.652			NA	N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			5	61					0	0	0.000602	0	0
KRT7	3855	broad.mit.edu	37	12	52639362	52639362	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr12:52639362C>T	uc001saa.1	+	7	1278	c.1151C>T	c.(1150-1152)GCC>GTC	p.A384V	KRT7_uc009zmf.1_Intron	NM_005556	NP_005547	P08729	K2C7_HUMAN	keratin 7	384	Rod.|Coil 2.				cytoskeleton organization|DNA replication|interphase|interspecies interaction between organisms|regulation of translation	Golgi apparatus|keratin filament|nucleus	protein binding|structural molecule activity				0				BRCA - Breast invasive adenocarcinoma(357;0.105)		GTGAAGCTGGCCCTGGACATC	0.637			NA											4	90					0	0	0.001168	0	0
PPP1R1A	5502	broad.mit.edu	37	12	54975870	54975870	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr12:54975870C>A	uc001sgg.2	-	5	464	c.293G>T	c.(292-294)GGA>GTA	p.G98V		NM_006741	NP_006732	Q13522	PPR1A_HUMAN	protein phosphatase 1, regulatory (inhibitor)	98					glycogen metabolic process|signal transduction		protein binding|protein serine/threonine phosphatase inhibitor activity				0						AGGTTCCTCTCCTTGCTGCTG	0.602			NA											20	57					2.94398e-08	4.15562e-08	0.007413	1	0
SLC39A5	283375	broad.mit.edu	37	12	56629470	56629470	+	Nonsense_Mutation	SNP	C	C	T			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr12:56629470C>T	uc010sqj.1	+	8	1188	c.931C>T	c.(931-933)CGA>TGA	p.R311*	SLC39A5_uc010sqi.1_Nonsense_Mutation_p.R202*|SLC39A5_uc010sqk.1_Nonsense_Mutation_p.R311*	NM_173596	NP_775867	Q6ZMH5	S39A5_HUMAN	solute carrier family 39 (metal ion	311	Cytoplasmic (Potential).				zinc ion transport	basolateral plasma membrane|integral to membrane	metal ion transmembrane transporter activity			ovary(1)|skin(1)	2						TTTGCGGCACCGAGGGCTCAG	0.532			NA											28	372					0	0	0.00632	0	0
Unknown	0	broad.mit.edu	37	12	80771682	80771682	+	Missense_Mutation	SNP	A	A	G			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr12:80771682A>G	uc009zsg.1	+	13	1130	c.529A>G	c.(529-531)AAT>GAT	p.N177D	uc001szd.2_Missense_Mutation_p.N316D					RecName: Full=Uncharacterized protein C12orf64;												NA						ATATAACATCAATATTGAAAG	0.358			NA											4	11					0	0	0.001168	0	0
TMTC2	160335	broad.mit.edu	37	12	83358817	83358817	+	Missense_Mutation	SNP	A	A	T			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr12:83358817A>T	uc001szt.2	+	5	2045	c.1613A>T	c.(1612-1614)CAG>CTG	p.Q538L	TMTC2_uc001szr.1_Missense_Mutation_p.Q538L|TMTC2_uc001szs.1_Missense_Mutation_p.Q538L|TMTC2_uc010suk.1_Missense_Mutation_p.Q293L	NM_152588	NP_689801	Q8N394	TMTC2_HUMAN	transmembrane and tetratricopeptide repeat	538	TPR 3.					endoplasmic reticulum|integral to membrane	binding			ovary(2)	2						CTACTTCTCCAGGAGAACAGC	0.333			NA											26	57					0	0	0.00632	0	0
ALX1	8092	broad.mit.edu	37	12	85695135	85695135	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr12:85695135G>T	uc001tae.3	+	4	867	c.863G>T	c.(862-864)GGG>GTG	p.G288V		NM_006982	NP_008913	Q15699	ALX1_HUMAN	cartilage paired-class homeoprotein 1	288					brain development|cartilage condensation|negative regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter		sequence-specific DNA binding transcription factor activity|transcription corepressor activity			ovary(1)|central_nervous_system(1)	2				GBM - Glioblastoma multiforme(134;0.134)		CTTCTTACTGGGGCAACCAAT	0.483			NA											11	106					2.80697e-09	4.17525e-09	0.000978	1	0
TCHP	84260	broad.mit.edu	37	12	110348913	110348913	+	Nonsense_Mutation	SNP	G	G	T			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr12:110348913G>T	uc001tpn.2	+	9	1078	c.925G>T	c.(925-927)GAG>TAG	p.E309*	TCHP_uc001tpo.1_RNA|TCHP_uc001tpp.2_Nonsense_Mutation_p.E309*	NM_001143852	NP_001137324	Q9BT92	TCHP_HUMAN	trichoplein	309	Trichohyalin/plectin homology domain.|Glu-rich.|Interaction with keratin proteins.|Potential.				apoptosis|negative regulation of cell growth	apical cortex|centrosome|keratin filament|mitochondrion|plasma membrane	protein binding			skin(1)	1						GAAGGAGGACGAGAGCCAGCG	0.667			NA											3	13					0.004672	0.0050756	0.004672	1	0
P2RX7	5027	broad.mit.edu	37	12	121600296	121600296	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr12:121600296C>G	uc001tzm.2	+	5	602	c.506C>G	c.(505-507)CCC>CGC	p.P169R	P2RX7_uc001tzn.2_Missense_Mutation_p.P79R|P2RX7_uc001tzo.2_RNA|P2RX7_uc001tzp.2_5'UTR|P2RX7_uc001tzq.2_Intron	NM_002562	NP_002553	Q99572	P2RX7_HUMAN	purinergic receptor P2X7	169						integral to membrane	ATP binding|ion channel activity|receptor activity			large_intestine(2)|lung(1)|breast(1)|skin(1)	5	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)					GCCTGGTGCCCCATCGAGGCA	0.592			NA											4	60					0	0	0.000602	0	0
TMEM132B	114795	broad.mit.edu	37	12	126137173	126137173	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr12:126137173C>A	uc001uhe.1	+	8	2094	c.2086C>A	c.(2086-2088)CAG>AAG	p.Q696K	TMEM132B_uc001uhf.1_Missense_Mutation_p.Q208K	NM_052907	NP_443139	Q14DG7	T132B_HUMAN	transmembrane protein 132B	696	Extracellular (Potential).					integral to membrane				skin(11)|ovary(5)|large_intestine(1)|pancreas(1)|breast(1)	19	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000423)|Epithelial(86;0.00394)|all cancers(50;0.0362)		TCAGTCCCCACAGCAGGTGAG	0.607			NA											6	84					0.00198382	0.00218378	0.001984	1	0
RIMBP2	23504	broad.mit.edu	37	12	130912844	130912844	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr12:130912844G>T	uc001uil.2	-	12	2405	c.2241C>A	c.(2239-2241)AGC>AGA	p.S747R		NM_015347	NP_056162	O15034	RIMB2_HUMAN	RIM-binding protein 2	747						cell junction|synapse				upper_aerodigestive_tract(3)|ovary(3)|large_intestine(2)|central_nervous_system(2)|pancreas(1)	11	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.213)		OV - Ovarian serous cystadenocarcinoma(86;4.29e-06)|all cancers(50;4.56e-05)|Epithelial(86;5.41e-05)		ACCCCCGGCTGCTCTCTGTGT	0.617			NA											14	96					3.41278e-10	5.22622e-10	0.00499	1	0
FLT3	2322	broad.mit.edu	37	13	28589815	28589815	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr13:28589815C>A	uc001urw.2	-	21	2647	c.2565G>T	c.(2563-2565)ATG>ATT	p.M855I	FLT3_uc010aao.2_RNA|FLT3_uc010tdn.1_Missense_Mutation_p.M814I	NM_004119	NP_004110	P36888	FLT3_HUMAN	fms-related tyrosine kinase 3 precursor	855	Protein kinase.|Cytoplasmic (Potential).				positive regulation of cell proliferation	integral to plasma membrane	ATP binding|vascular endothelial growth factor receptor activity			haematopoietic_and_lymphoid_tissue(8536)|lung(7)|ovary(3)|stomach(1)|central_nervous_system(1)|skin(1)	8549	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0156)|Ovarian(182;0.0392)	Colorectal(13;0.000157)|READ - Rectum adenocarcinoma(15;0.105)	OV - Ovarian serous cystadenocarcinoma(117;0.00154)|all cancers(112;0.00459)|GBM - Glioblastoma multiforme(144;0.00562)|Epithelial(112;0.0959)|Lung(94;0.212)	Sorafenib(DB00398)|Sunitinib(DB01268)	TTTCGGGGGCCATCCATTTTA	0.428			NA	Mis|O		AML|ALL								16	85					4.35082e-09	6.42558e-09	0.010504	1	0
POTEG	404785	broad.mit.edu	37	14	19553724	19553724	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr14:19553724G>T	uc001vuz.1	+	1	360	c.308G>T	c.(307-309)TGC>TTC	p.C103F	POTEG_uc001vva.1_RNA|POTEG_uc010ahc.1_RNA	NM_001005356	NP_001005356	Q6S5H5	POTEG_HUMAN	POTE ankyrin domain family, member G	103										ovary(1)	1						AAGTGGTGCTGCCACTGCTTC	0.617			NA											37	435					2.29192e-23	4.34313e-23	0.00361	1	0
IL25	64806	broad.mit.edu	37	14	23842381	23842381	+	Silent	SNP	A	A	T			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr14:23842381A>T	uc001wjr.2	+	1	364	c.54A>T	c.(52-54)CTA>CTT	p.L18L	IL25_uc001wjq.2_Intron	NM_022789	NP_073626	Q9H293	IL25_HUMAN	interleukin 25 isoform 1 precursor	18					inflammatory response	extracellular space|membrane	cytokine activity|interleukin-17E receptor binding			ovary(1)	1	all_cancers(95;2e-05)			GBM - Glioblastoma multiforme(265;0.00665)|READ - Rectum adenocarcinoma(4;0.0276)|Colorectal(4;0.0396)		GCCTTTTCCTACAGGTGGTTG	0.587			NA											34	107					0	0	0.003271	0	0
ARHGAP5	394	broad.mit.edu	37	14	32563233	32563233	+	Missense_Mutation	SNP	A	A	G			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr14:32563233A>G	uc001wrl.2	+	2	3597	c.3358A>G	c.(3358-3360)AAA>GAA	p.K1120E	ARHGAP5_uc001wrm.2_Missense_Mutation_p.K1120E|ARHGAP5_uc001wrn.2_Missense_Mutation_p.K1120E|ARHGAP5_uc001wro.2_Intron|ARHGAP5_uc001wrp.2_Intron	NM_001173	NP_001025226	Q13017	RHG05_HUMAN	Rho GTPase activating protein 5 isoform b	1120					cell adhesion|Rho protein signal transduction	cytosol|membrane	GTP binding|GTPase activity|Rho GTPase activator activity|SH2 domain binding			ovary(4)|central_nervous_system(1)	5	Hepatocellular(127;0.0604)|Prostate(35;0.15)|Breast(36;0.186)		LUAD - Lung adenocarcinoma(48;0.00192)|Lung(238;0.00714)|BRCA - Breast invasive adenocarcinoma(188;0.0952)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.00566)		AAATCGTATTAAAATTCGAAA	0.363	NSCLC(9;77 350 3443 29227 41353)		NA											3	84					0	0	0.004672	0	0
SYT16	83851	broad.mit.edu	37	14	62462844	62462844	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr14:62462844C>A	uc001xfu.1	+	1	304	c.107C>A	c.(106-108)TCT>TAT	p.S36Y	SYT16_uc010tsd.1_Missense_Mutation_p.S36Y	NM_031914	NP_114120	Q17RD7	SYT16_HUMAN	synaptotagmin XIV-like	36										central_nervous_system(1)	1				OV - Ovarian serous cystadenocarcinoma(108;0.0438)|BRCA - Breast invasive adenocarcinoma(234;0.118)		GATATGTTATCTGCTTCGCTG	0.413			NA											19	62					3.51602e-12	5.72214e-12	0.008871	1	0
MOAP1	64112	broad.mit.edu	37	14	93649642	93649642	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr14:93649642C>G	uc001ybj.2	-	3	1316	c.946G>C	c.(946-948)GAT>CAT	p.D316H	C14orf109_uc001ybk.3_5'Flank|C14orf109_uc010auo.2_5'Flank	NM_022151	NP_071434	Q96BY2	MOAP1_HUMAN	modulator of apoptosis 1	316					activation of caspase activity|apoptotic nuclear change	cytoplasm	protein homodimerization activity			skin(2)|ovary(1)	3		all_cancers(154;0.00528)|Acute lymphoblastic leukemia(33;0.0497)|all_epithelial(191;0.125)|all_neural(303;0.13)		Epithelial(152;0.178)|all cancers(159;0.2)|COAD - Colon adenocarcinoma(157;0.204)		gctgggccatcctctggcaga	0.075			NA											56	133					0	0	0.00361	0	0
ADSSL1	122622	broad.mit.edu	37	14	105201358	105201358	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr14:105201358G>T	uc001ypd.2	+	2	268	c.194G>T	c.(193-195)GGG>GTG	p.G65V	INF2_uc010tyi.1_Intron|ADSSL1_uc001ype.2_Missense_Mutation_p.G108V|ADSSL1_uc001ypf.2_RNA	NM_152328	NP_689541	Q8N142	PURA1_HUMAN	adenylosuccinate synthase like 1 isoform 2	65					AMP biosynthetic process|immune system process|purine base metabolic process	cytosol	adenylosuccinate synthase activity|GTP binding|magnesium ion binding|phosphate binding			ovary(1)|central_nervous_system(1)	2		all_cancers(154;0.0896)|Melanoma(154;0.155)|all_epithelial(191;0.172)	all cancers(16;0.00153)|OV - Ovarian serous cystadenocarcinoma(23;0.0148)|Epithelial(46;0.0396)|GBM - Glioblastoma multiforme(11;0.116)	Epithelial(152;0.18)	L-Aspartic Acid(DB00128)	CTGTTCCAGGGGGGCAACAAC	0.617			NA											6	30					1.06961e-07	1.45062e-07	0.00308	1	0
TRPM1	4308	broad.mit.edu	37	15	31360169	31360169	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr15:31360169G>T	uc001zfm.2	-	4	468	c.340C>A	c.(340-342)CCC>ACC	p.P114T	TRPM1_uc010azy.2_Missense_Mutation_p.P27T|TRPM1_uc001zfl.2_RNA|uc010ubm.1_5'Flank|MIR211_hsa-mir-211|MI0000287_5'Flank|uc010ubn.1_5'Flank	NM_002420	NP_002411	Q7Z4N2	TRPM1_HUMAN	transient receptor potential cation channel,	114	Extracellular (Potential).				cellular response to light stimulus|visual perception	integral to plasma membrane	calcium channel activity|receptor activity			ovary(2)|pancreas(1)|skin(1)	4		all_lung(180;1.92e-11)		all cancers(64;3.52e-16)|Epithelial(43;1.65e-11)|GBM - Glioblastoma multiforme(186;3.57e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00533)|COAD - Colon adenocarcinoma(236;0.0609)|Lung(196;0.199)		TTCAGCTTGGGCTGCATCTCA	0.547			NA											22	214					5.26018e-13	8.7319e-13	0.001882	1	0
C15orf55	256646	broad.mit.edu	37	15	34640216	34640216	+	Silent	SNP	C	C	T			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr15:34640216C>T	uc001zif.2	+	2	218	c.63C>T	c.(61-63)GCC>GCT	p.A21A	C15orf55_uc010ucc.1_Silent_p.A49A|C15orf55_uc010ucd.1_Silent_p.A39A	NM_175741	NP_786883	Q86Y26	NUT_HUMAN	nuclear protein in testis	21	Pro-rich.					cytoplasm|nucleus			BRD4_ENST00000263377/C15orf55(24)|BRD3/C15orf55(3)	midline_organs(25)|ovary(2)|lung(2)|skin(1)	30		all_lung(180;2.78e-08)		all cancers(64;4.53e-18)|GBM - Glioblastoma multiforme(113;8.29e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0249)		CTAGTGCCGCCCCGTCTCCAT	0.532			NA	T	BRD3|BRD4	lethal midline carcinoma								11	90					0	0	0.001368	0	0
CASC5	57082	broad.mit.edu	37	15	40912855	40912855	+	Silent	SNP	T	T	C			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr15:40912855T>C	uc010bbs.1	+	11	632	c.471T>C	c.(469-471)CAT>CAC	p.H157H	CASC5_uc010ucq.1_5'UTR|CASC5_uc001zme.2_Silent_p.H131H|CASC5_uc010bbt.1_Silent_p.H131H	NM_170589	NP_733468	Q8NG31	CASC5_HUMAN	cancer susceptibility candidate 5 isoform 1	157	Interaction with BUB1 and BUB1B.				acrosome assembly|attachment of spindle microtubules to kinetochore|cell division|CenH3-containing nucleosome assembly at centromere|mitotic prometaphase|spindle assembly checkpoint	acrosomal vesicle|condensed chromosome kinetochore|cytosol|nucleoplasm	protein binding			breast(3)|central_nervous_system(1)|skin(1)	5		all_cancers(109;2.03e-18)|all_epithelial(112;4.26e-15)|Lung NSC(122;1.12e-10)|all_lung(180;2.59e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.0946)		GBM - Glioblastoma multiforme(113;4.99e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0861)|COAD - Colon adenocarcinoma(120;0.211)		TTATAGAACATACCCGTGAAA	0.313			NA											7	56					0	0	0.001984	0	0
MAP1A	4130	broad.mit.edu	37	15	43819588	43819588	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr15:43819588C>A	uc001zrt.2	+	4	6384	c.5917C>A	c.(5917-5919)CAG>AAG	p.Q1973K		NM_002373	NP_002364	P78559	MAP1A_HUMAN	microtubule-associated protein 1A	1973						cytoplasm|microtubule|microtubule associated complex	protein binding|structural molecule activity			ovary(3)|breast(3)|pancreas(2)|skin(1)	9		all_cancers(109;1.03e-14)|all_epithelial(112;2.23e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.05e-06)	Estramustine(DB01196)	CATCTATGAGCAGATGATGCT	0.582			NA											5	111					0.000157383	0.000184503	0.00308	1	0
CPLX3	594855	broad.mit.edu	37	15	75119191	75119191	+	Silent	SNP	G	G	A			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr15:75119191G>A	uc002ayu.1	+	1	241	c.147G>A	c.(145-147)AAG>AAA	p.K49K	LMAN1L_uc010bke.1_3'UTR	NM_001030005	NP_001025176	Q8WVH0	CPLX3_HUMAN	complexin 3 precursor	49	Potential.					cell junction|synapse	syntaxin binding				0						AGTATCAGAAGCAACTCGTGG	0.637			NA											6	44					0	0	0.001984	0	0
ULK3	25989	broad.mit.edu	37	15	75134424	75134424	+	Missense_Mutation	SNP	T	T	A			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr15:75134424T>A	uc010bkf.1	-	3	462	c.356A>T	c.(355-357)CAG>CTG	p.Q119L	ULK3_uc010ulp.1_Missense_Mutation_p.Q29L|ULK3_uc010ulq.1_Missense_Mutation_p.Q130L|ULK3_uc010ulr.1_Missense_Mutation_p.Q2L|ULK3_uc002ayv.2_Missense_Mutation_p.Q119L|ULK3_uc010uls.1_Missense_Mutation_p.Q2L|ULK3_uc010ult.1_Missense_Mutation_p.Q29L|ULK3_uc010ulu.1_Missense_Mutation_p.Q29L	NM_001099436	NP_001092906	Q6PHR2	ULK3_HUMAN	unc-51-like kinase 3	119	Protein kinase.					cytoplasm	ATP binding|protein serine/threonine kinase activity			breast(2)	2						ACCTAATTGCTGCATGAAGAC	0.577			NA											17	192					0	0	0.008871	0	0
LOC645752	645752	broad.mit.edu	37	15	78211193	78211193	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr15:78211193G>T	uc010bky.2	-	11	1338	c.574C>A	c.(574-576)CAA>AAA	p.Q192K		NR_027024				SubName: Full=GOLGA6 protein; Flags: Fragment;												0						TCCTGCTTTTGTAGCCTGTCC	0.592			NA											11	166					1.15919e-05	1.45776e-05	0.008871	1	0
ZNF597	146434	broad.mit.edu	37	16	3490906	3490906	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr16:3490906C>G	uc002cvd.2	-	3	245	c.61G>C	c.(61-63)GTG>CTG	p.V21L	NAT15_uc002cvh.3_5'Flank|NAT15_uc010uxb.1_5'Flank	NM_152457	NP_689670	Q96LX8	ZN597_HUMAN	zinc finger protein 597	21	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						GAAAAATACACAGCCAGATCC	0.512			NA											12	86					0	0	0.001855	0	0
GRIN2A	2903	broad.mit.edu	37	16	9857275	9857275	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr16:9857275G>T	uc002czo.3	-	13	4674	c.4126C>A	c.(4126-4128)CGC>AGC	p.R1376S	GRIN2A_uc010uym.1_Missense_Mutation_p.R1376S|GRIN2A_uc010uyn.1_Missense_Mutation_p.N1104K|GRIN2A_uc002czr.3_Missense_Mutation_p.N1261K	NM_001134407	NP_001127879	Q12879	NMDE1_HUMAN	N-methyl-D-aspartate receptor subunit 2A isoform	1376	Cytoplasmic (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			skin(32)|NS(5)|ovary(4)|large_intestine(1)|lung(1)|breast(1)|kidney(1)	45					Felbamate(DB00949)|Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	ATAACCAAGCGTTGGTCATCC	0.562			NA											17	87					1.00905e-13	1.71621e-13	0.008871	1	0
MYH11	4629	broad.mit.edu	37	16	15839064	15839064	+	Silent	SNP	G	G	T			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr16:15839064G>T	uc002ddy.2	-	20	2549	c.2442C>A	c.(2440-2442)ACC>ACA	p.T814T	MYH11_uc002ddv.2_Silent_p.T821T|MYH11_uc002ddw.2_Silent_p.T814T|MYH11_uc002ddx.2_Silent_p.T821T|MYH11_uc010bvg.2_Silent_p.T646T	NM_002474	NP_002465	P35749	MYH11_HUMAN	smooth muscle myosin heavy chain 11 isoform	814	IQ.				axon guidance|cardiac muscle fiber development|elastic fiber assembly|skeletal muscle myosin thick filament assembly|smooth muscle contraction	cytosol|melanosome|muscle myosin complex|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			ovary(6)|skin(3)|lung(2)|breast(2)|upper_aerodigestive_tract(1)|pancreas(1)	15						CCTTCATGGCGGTCAGCTGCT	0.617			NA	T	CBFB	AML								15	64					3.45872e-05	4.28468e-05	0.004007	1	0
ACSM2B	348158	broad.mit.edu	37	16	20554536	20554536	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr16:20554536G>T	uc002dhj.3	-	12	1540	c.1330C>A	c.(1330-1332)CTT>ATT	p.L444I	ACSM2B_uc002dhk.3_Missense_Mutation_p.L444I|ACSM2B_uc010bwf.1_Missense_Mutation_p.L444I	NM_182617	NP_872423	Q68CK6	ACS2B_HUMAN	acyl-CoA synthetase medium-chain family member	444					fatty acid metabolic process|xenobiotic metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|CoA-ligase activity|metal ion binding			skin(3)|ovary(1)|central_nervous_system(1)	5						CGGTCTCCAAGGAGCCAAAAG	0.493			NA											28	264					3.73988e-18	6.74805e-18	0.00632	1	0
USP31	57478	broad.mit.edu	37	16	23080502	23080502	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr16:23080502C>T	uc002dll.2	-	16	2924	c.2924G>A	c.(2923-2925)CGC>CAC	p.R975H	USP31_uc002dlk.2_Missense_Mutation_p.R247H|USP31_uc010vca.1_Missense_Mutation_p.R278H|USP31_uc010bxm.2_Missense_Mutation_p.R263H	NM_020718	NP_065769	Q70CQ4	UBP31_HUMAN	ubiquitin specific peptidase 31	975	Ser-rich.				ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity			ovary(3)|lung(3)|breast(2)|pancreas(1)|skin(1)	10				GBM - Glioblastoma multiforme(48;0.0187)		CGGGGGCAGGCGGTCCCCTTG	0.517			NA											20	142					0	0	0.008871	0	0
ITGAX	3687	broad.mit.edu	37	16	31391640	31391640	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr16:31391640C>G	uc002ebu.1	+	27	3181	c.3114C>G	c.(3112-3114)AGC>AGG	p.S1038R	ITGAX_uc002ebt.2_Missense_Mutation_p.S1038R	NM_000887	NP_000878	P20702	ITAX_HUMAN	integrin alpha X precursor	1038	Extracellular (Potential).				blood coagulation|cell adhesion|integrin-mediated signaling pathway|leukocyte migration|organ morphogenesis	integrin complex	protein binding|receptor activity			ovary(2)|central_nervous_system(1)|pancreas(1)	4						CCTCCTTCAGCGTCCAGGAGG	0.607			NA											4	34					0	0	0.009096	0	0
CBLN1	869	broad.mit.edu	37	16	49313499	49313499	+	Missense_Mutation	SNP	A	A	C			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr16:49313499A>C	uc002efq.2	-	3	737	c.398T>G	c.(397-399)CTA>CGA	p.L133R		NM_004352	NP_004343	P23435	CBLN1_HUMAN	cerebellin 1 precursor	133	C1q.|Necessary for interaction with CBLN3, and homotrimerization (By similarity).				nervous system development|synaptic transmission	cell junction|extracellular region|synapse					0		all_cancers(37;0.0766)|all_lung(18;0.24)				CCACCCGTTTAGCATGAGGCT	0.607			NA											8	56					0	0	0.006214	0	0
SALL1	6299	broad.mit.edu	37	16	51173271	51173271	+	Silent	SNP	G	G	A			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr16:51173271G>A	uc010vgs.1	-	2	2893	c.2862C>T	c.(2860-2862)AGC>AGT	p.S954S	SALL1_uc010vgr.1_Silent_p.S857S|SALL1_uc010cbv.2_Intron	NM_002968	NP_002959	Q9NSC2	SALL1_HUMAN	sal-like 1 isoform a	954					adrenal gland development|branching involved in ureteric bud morphogenesis|embryonic digestive tract development|embryonic digit morphogenesis|gonad development|histone deacetylation|inductive cell-cell signaling|mesenchymal to epithelial transition involved in metanephros morphogenesis|negative regulation of transcription from RNA polymerase II promoter|olfactory bulb interneuron differentiation|olfactory bulb mitral cell layer development|olfactory nerve development|outer ear morphogenesis|pituitary gland development|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway|ureteric bud invasion|ventricular septum development	chromocenter|cytoplasm|heterochromatin|nucleus	beta-catenin binding|DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(5)|ovary(3)	8		all_cancers(37;0.0322)	COAD - Colon adenocarcinoma(2;0.24)			TGGCAAACTCGCTTGGGACCG	0.517	GBM(103;1352 1446 1855 4775 8890)		NA											9	60					0	0	0.008291	0	0
SLC6A2	6530	broad.mit.edu	37	16	55728015	55728015	+	Missense_Mutation	SNP	A	A	T			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr16:55728015A>T	uc002eif.2	+	7	1123	c.1012A>T	c.(1012-1014)AAC>TAC	p.N338Y	SLC6A2_uc010ccd.2_Missense_Mutation_p.N338Y|SLC6A2_uc002eig.2_Missense_Mutation_p.N338Y|SLC6A2_uc002eih.2_Missense_Mutation_p.N338Y|SLC6A2_uc002eii.2_Missense_Mutation_p.N233Y|SLC6A2_uc002eij.2_Missense_Mutation_p.N52Y	NM_001043	NP_001034	P23975	SC6A2_HUMAN	solute carrier family 6 member 2	338					synaptic transmission	integral to plasma membrane|membrane fraction	norepinephrine:sodium symporter activity			lung(4)|ovary(2)|pancreas(2)	8				BRCA - Breast invasive adenocarcinoma(181;0.01)|Kidney(780;0.0267)	Amineptine(DB04836)|Amitriptyline(DB00321)|Amoxapine(DB00543)|Atomoxetine(DB00289)|Bethanidine(DB00217)|Bupropion(DB01156)|Clomipramine(DB01242)|Cocaine(DB00907)|Debrisoquin(DB04840)|Desipramine(DB01151)|Diethylpropion(DB00937)|Doxepin(DB01142)|Duloxetine(DB00476)|Ergotamine(DB00696)|Guanadrel Sulfate(DB00226)|Guanethidine(DB01170)|Imipramine(DB00458)|Maprotiline(DB00934)|Mazindol(DB00579)|Methylphenidate(DB00422)|Milnacipran(DB04896)|Nefazodone(DB01149)|Norepinephrine(DB00368)|Nortriptyline(DB00540)|Paroxetine(DB00715)|Phenmetrazine(DB00830)|Phentermine(DB00191)|Protriptyline(DB00344)|Reboxetine(DB00234)|Sibutramine(DB01105)|Tramadol(DB00193)|Trazodone(DB00656)|Trimipramine(DB00726)|Venlafaxine(DB00285)	ATTTGACAACAACTGTTACAG	0.438			NA											32	161					0	0	0.003271	0	0
GNAO1	2775	broad.mit.edu	37	16	56377812	56377812	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr16:56377812G>T	uc002eit.3	+	8	1912	c.1015G>T	c.(1015-1017)GTG>TTG	p.V339L	GNAO1_uc002eiu.3_Intron	NM_138736	NP_620073	P09471	GNAO_HUMAN	guanine nucleotide binding protein, alpha	339					dopamine receptor signaling pathway|G-protein signaling, coupled to cAMP nucleotide second messenger|muscle contraction	heterotrimeric G-protein complex	G-protein beta/gamma-subunit complex binding|GTP binding|GTPase activity|metabotropic serotonin receptor binding|signal transducer activity			lung(1)|breast(1)	2		all_neural(199;0.159)				CTTTGATGCTGTGACGGACGT	0.617			NA											11	74					6.40141e-05	7.74515e-05	0.000978	1	0
TMCO7	79613	broad.mit.edu	37	16	68894053	68894053	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr16:68894053C>T	uc002ewi.3	+	2	373	c.361C>T	c.(361-363)CCC>TCC	p.P121S	TMCO7_uc002ewh.2_Missense_Mutation_p.P121S	NM_024562	NP_078838	Q9C0B7	TMCO7_HUMAN	transmembrane and coiled-coil domains 7	121						integral to membrane	binding				0		Ovarian(137;0.0568)		OV - Ovarian serous cystadenocarcinoma(108;0.0446)|Epithelial(162;0.198)		TCCAGGTAAACCCAACCCTAG	0.468			NA											46	280					0	0	0.00361	0	0
HYDIN	54768	broad.mit.edu	37	16	71019123	71019123	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr16:71019123G>T	uc002ezr.2	-	28	4422	c.4294C>A	c.(4294-4296)CTT>ATT	p.L1432I		NM_032821	NP_116210	Q4G0P3	HYDIN_HUMAN	hydrocephalus inducing isoform a	1433										ovary(1)|skin(1)	2		Ovarian(137;0.0654)				CCAGGGAGAAGGTTGTCTGGA	0.517			NA											7	30					0.00621372	0.0066979	0.006214	1	0
CNTNAP4	85445	broad.mit.edu	37	16	76461392	76461392	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr16:76461392G>T	uc002feu.1	+	6	819	c.434G>T	c.(433-435)AGA>ATA	p.R145I	CNTNAP4_uc002fev.1_Missense_Mutation_p.R57I|CNTNAP4_uc010chb.1_Missense_Mutation_p.R120I|CNTNAP4_uc002fex.1_Missense_Mutation_p.R148I|CNTNAP4_uc002few.2_Missense_Mutation_p.R120I	NM_033401	NP_207837	Q9C0A0	CNTP4_HUMAN	cell recognition protein CASPR4 isoform 1	145	Extracellular (Potential).|F5/8 type C.				cell adhesion|signal transduction	integral to membrane	receptor binding			ovary(1)|pancreas(1)	2						GTGTACTATAGACTCCAGCCT	0.433			NA											30	143					2.80507e-11	4.46017e-11	0.002445	1	0
ADAMTS18	170692	broad.mit.edu	37	16	77317955	77317955	+	Nonsense_Mutation	SNP	G	G	T			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr16:77317955G>T	uc002ffc.3	-	23	3983	c.3564C>A	c.(3562-3564)TGC>TGA	p.C1188*		NM_199355	NP_955387	Q8TE60	ATS18_HUMAN	ADAM metallopeptidase with thrombospondin type 1	1188	PLAC.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			large_intestine(4)|lung(4)|kidney(4)|skin(3)|breast(1)|ovary(1)|pancreas(1)	18						AGAAATCTACGCAGGATGGAT	0.333			NA											6	98					0.00198382	0.00218378	0.001984	1	0
COTL1	23406	broad.mit.edu	37	16	84623755	84623755	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr16:84623755C>T	uc002fid.2	-	3	423	c.274G>A	c.(274-276)GCC>ACC	p.A92T	COTL1_uc002fie.2_Intron|COTL1_uc010chk.2_RNA	NM_021149	NP_066972	Q14019	COTL1_HUMAN	coactosin-like 1	92	ADF-H.					cytoplasm|cytoskeleton	actin binding|enzyme binding			skin(1)	1						CCGGTTTTGGCGCGCTGCAGC	0.597			NA											4	81					0	0	0.009096	0	0
CENPBD1	92806	broad.mit.edu	37	16	90038268	90038268	+	Silent	SNP	C	C	G			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr16:90038268C>G	uc002fpr.2	-	1	675	c.63G>C	c.(61-63)GCG>GCC	p.A21A	AFG3L1_uc002fps.1_5'Flank|AFG3L1_uc002fpt.1_5'Flank|AFG3L1_uc002fpu.1_5'Flank|AFG3L1_uc002fpv.1_5'Flank|AFG3L1_uc002fpw.1_5'Flank|AFG3L1_uc002fpx.1_5'Flank	NM_145039	NP_659476	B2RD01	CENP1_HUMAN	CENPB DNA-binding domains containing 1	21	HTH psq-type.				regulation of transcription, DNA-dependent	chromosome, centromeric region|nucleus	DNA binding				0						CAAGGGTAATCGCTTTCCGTT	0.488			NA											9	50					0	0	0.000978	0	0
CHRNE	1145	broad.mit.edu	37	17	4804399	4804399	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr17:4804399C>A	uc002fzk.1	-	7	699	c.688G>T	c.(688-690)GTC>TTC	p.V230F	C17orf107_uc002fzl.3_3'UTR	NM_000080	NP_000071	Q04844	ACHE_HUMAN	nicotinic acetylcholine receptor epsilon	230	Extracellular (Potential).				muscle contraction|synaptic transmission, cholinergic	cell junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity				0						GAGTAGATGACGTCAGTCTCC	0.652			NA											14	112					1.5739e-10	2.45552e-10	0.004007	1	0
TP53	7157	broad.mit.edu	37	17	7577535	7577535	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr17:7577535C>A	uc002gim.2	-	7	940	c.746G>T	c.(745-747)AGG>ATG	p.R249M	TP53_uc002gig.1_Missense_Mutation_p.R249M|TP53_uc002gih.2_Missense_Mutation_p.R249M|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.R117M|TP53_uc010cng.1_Missense_Mutation_p.R117M|TP53_uc002gii.1_Missense_Mutation_p.R117M|TP53_uc010cnh.1_Missense_Mutation_p.R249M|TP53_uc010cni.1_Missense_Mutation_p.R249M|TP53_uc002gij.2_Missense_Mutation_p.R249M|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.R156M|TP53_uc002gio.2_Missense_Mutation_p.R117M	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	249	|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		R -> W (in sporadic cancers; somatic mutation).|RP -> SA (in a sporadic cancer; somatic mutation).|RP -> SS (in sporadic cancers; somatic mutation).|R -> T (in sporadic cancers; somatic mutation).|R -> N (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|R -> I (in a sporadic cancer; somatic mutation).|R -> M (in sporadic cancers; somatic mutation).|R -> G (in sporadic cancers; somatic mutation).|R -> K (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R249S(303)|p.R249M(25)|p.R249G(24)|p.R249W(23)|p.R249T(16)|p.R249K(14)|p.0?(7)|p.R249R(6)|p.R249fs*96(6)|p.M246_P250delMNRRP(2)|p.R249fs*14(2)|p.R248_P250delRRP(1)|p.R249_P250delRP(1)|p.R249_P250insR(1)|p.R249_P250>SS(1)|p.N247_R249delNRR(1)|p.N247_P250delNRRP(1)|p.R249fs*19(1)|p.R249_T256delRPILTIIT(1)|p.R249fs*15(1)|p.R249_I251delRPI(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GAGGATGGGCCTCCGGTTCAT	0.567	Pancreas(47;798 1329 9957 10801)		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumensyndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			17	55					1.40151e-16	2.50701e-16	0.010504	1	0
MYH8	4626	broad.mit.edu	37	17	10298575	10298575	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr17:10298575C>G	uc002gmm.2	-	34	4932	c.4837G>C	c.(4837-4839)GAT>CAT	p.D1613H	uc002gml.1_Intron	NM_002472	NP_002463	P13535	MYH8_HUMAN	myosin, heavy chain 8, skeletal muscle,	1613	Potential.				muscle filament sliding	cytosol|muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			skin(6)|ovary(3)|breast(2)	11						CTCAGAGCATCATTTCTGCTT	0.448			NA							Trismus-Pseudocamptodactyly_Syndrome_with_Cardiac_Myxoma_and_Freckling				17	143					0	0	0.00499	0	0
MYH8	4626	broad.mit.edu	37	17	10301785	10301785	+	Missense_Mutation	SNP	C	C	A	rs147143044		TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr17:10301785C>A	uc002gmm.2	-	30	4249	c.4154G>T	c.(4153-4155)CGC>CTC	p.R1385L	uc002gml.1_Intron	NM_002472	NP_002463	P13535	MYH8_HUMAN	myosin, heavy chain 8, skeletal muscle,	1385	Potential.				muscle filament sliding	cytosol|muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			skin(6)|ovary(3)|breast(2)	11						CTCCTCTGTGCGCTGGATGGC	0.512			NA							Trismus-Pseudocamptodactyly_Syndrome_with_Cardiac_Myxoma_and_Freckling				47	227					1.38658e-30	2.70155e-30	0.00361	1	0
DNAH9	1770	broad.mit.edu	37	17	11757701	11757701	+	Missense_Mutation	SNP	A	A	T			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr17:11757701A>T	uc002gne.2	+	50	9957	c.9889A>T	c.(9889-9891)ACA>TCA	p.T3297S	DNAH9_uc010coo.2_Missense_Mutation_p.T2591S	NM_001372	NP_001363	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9 isoform 2	3297	Stalk (By similarity).|Potential.				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			skin(10)|ovary(4)|breast(3)|central_nervous_system(2)|pancreas(1)	20		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		CGCGGACCTCACAGCTGCCCA	0.557			NA											13	58					0	0	0.00245	0	0
MAPK7	5598	broad.mit.edu	37	17	19285382	19285382	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr17:19285382C>G	uc002gvn.2	+	5	2152	c.1766C>G	c.(1765-1767)CCT>CGT	p.P589R	MAPK7_uc002gvo.2_Missense_Mutation_p.P450R|MAPK7_uc002gvq.2_Missense_Mutation_p.P589R|MAPK7_uc002gvp.2_Missense_Mutation_p.P589R|uc010vyt.1_5'Flank	NM_139033	NP_620602	Q13164	MK07_HUMAN	mitogen-activated protein kinase 7 isoform 1	589	May not be required for kinase activity; required to stimulate MEF2C activity (By similarity).|Pro-rich.				cell cycle|cell differentiation|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|MAP kinase activity|protein binding	p.P589S(1)		central_nervous_system(4)|lung(3)|stomach(1)|skin(1)	9	all_cancers(12;2.87e-05)|all_epithelial(12;0.00114)|Hepatocellular(7;0.00345)|Breast(13;0.206)					gtgccggcccctgccccagcg	0.373			NA											5	12					0	0	0.001984	0	0
CPD	1362	broad.mit.edu	37	17	28754530	28754530	+	Silent	SNP	C	C	T			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr17:28754530C>T	uc002hfb.1	+	7	1986	c.1971C>T	c.(1969-1971)AGC>AGT	p.S657S	CPD_uc010wbo.1_Silent_p.S410S|CPD_uc010wbp.1_RNA	NM_001304	NP_001295	O75976	CBPD_HUMAN	carboxypeptidase D precursor	657	Extracellular (Potential).|Carboxypeptidase-like 2.				proteolysis	integral to membrane	metallocarboxypeptidase activity|serine-type carboxypeptidase activity|zinc ion binding			liver(1)|skin(1)	2						CTGTAATGAGCTGGATGAAGT	0.408			NA											24	179					0	0	0.00333	0	0
MYO1D	4642	broad.mit.edu	37	17	31075963	31075963	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr17:31075963C>A	uc002hho.1	-	12	1541	c.1529G>T	c.(1528-1530)GGC>GTC	p.G510V	MYO1D_uc002hhp.1_Missense_Mutation_p.G510V	NM_015194	NP_056009	O94832	MYO1D_HUMAN	myosin ID	510	Myosin head-like.					myosin complex	actin binding|ATP binding|calmodulin binding			large_intestine(1)|ovary(1)|central_nervous_system(1)	3			BRCA - Breast invasive adenocarcinoma(9;0.0362)			CACTACATCGCCTGCATAATG	0.368			NA											21	142					3.08376e-08	4.32352e-08	0.00333	1	0
MYO1D	4642	broad.mit.edu	37	17	31075976	31075976	+	Nonsense_Mutation	SNP	G	G	A			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr17:31075976G>A	uc002hho.1	-	12	1528	c.1516C>T	c.(1516-1518)CGA>TGA	p.R506*	MYO1D_uc002hhp.1_Nonsense_Mutation_p.R506*	NM_015194	NP_056009	O94832	MYO1D_HUMAN	myosin ID	506	Myosin head-like.					myosin complex	actin binding|ATP binding|calmodulin binding			large_intestine(1)|ovary(1)|central_nervous_system(1)	3			BRCA - Breast invasive adenocarcinoma(9;0.0362)			GCATAATGTCGAATTCGAAAA	0.373			NA											22	147					0	0	0.00333	0	0
CNTD1	124817	broad.mit.edu	37	17	40958759	40958759	+	Silent	SNP	C	C	T			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr17:40958759C>T	uc002ibm.3	+	5	880	c.648C>T	c.(646-648)GTC>GTT	p.V216V	CNTD1_uc010wha.1_Silent_p.V133V	NM_173478	NP_775749	Q8N815	CNTD1_HUMAN	cyclin N-terminal domain containing 1	216										central_nervous_system(1)	1		Breast(137;0.00104)		BRCA - Breast invasive adenocarcinoma(366;0.0749)		TCGACCTGGTCTATCTTCTGC	0.488			NA											17	164					0	0	0.007413	0	0
C17orf46	124783	broad.mit.edu	37	17	43332762	43332762	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr17:43332762G>A	uc002iis.1	-	4	883	c.787C>T	c.(787-789)CAC>TAC	p.H263Y	LOC100133991_uc010dah.2_Intron|C17orf46_uc010wjk.1_Missense_Mutation_p.H242Y	NM_152343	NP_689556	Q96LK8	CQ046_HUMAN	hypothetical protein LOC124783	263										large_intestine(1)|ovary(1)	2						TTCATCATGTGTTCCAAACTG	0.582			NA											6	97					0	0	0.001168	0	0
NXPH3	11248	broad.mit.edu	37	17	47656499	47656499	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr17:47656499G>T	uc002ipa.2	+	2	880	c.596G>T	c.(595-597)TGC>TTC	p.C199F	NXPH3_uc010wlw.1_Missense_Mutation_p.C199F	NM_007225	NP_009156	O95157	NXPH3_HUMAN	neurexophilin 3 precursor	199	V (Cys-rich).				neuropeptide signaling pathway	extracellular region				pancreas(1)|skin(1)	2	all_cancers(4;7.45e-14)|Breast(4;1.08e-27)|all_epithelial(4;2.27e-17)					GCCAAGATCTGCTCCCGAGAC	0.602			NA											24	132					2.79863e-10	4.31759e-10	0.004656	1	0
LRRC59	55379	broad.mit.edu	37	17	48462617	48462617	+	Missense_Mutation	SNP	T	T	C			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr17:48462617T>C	uc002iqt.2	-	6	692	c.538A>G	c.(538-540)AAG>GAG	p.K180E		NM_018509	NP_060979	Q96AG4	LRC59_HUMAN	leucine rich repeat containing 59	180	Potential.|Cytoplasmic (Potential).					endoplasmic reticulum membrane|integral to membrane|microsome|mitochondrial nucleoid	protein binding			central_nervous_system(1)	1	Breast(11;5.62e-19)		BRCA - Breast invasive adenocarcinoma(22;2.43e-08)			TGAGCTTCCTTAGCTCGCTGC	0.527			NA											35	224					0	0	0.006999	0	0
CA10	56934	broad.mit.edu	37	17	49710858	49710858	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr17:49710858C>A	uc002itw.3	-	8	1929	c.943G>T	c.(943-945)GCC>TCC	p.A315S	CA10_uc002itu.3_Missense_Mutation_p.A244S|CA10_uc002itv.3_Missense_Mutation_p.A321S|CA10_uc002itx.3_Missense_Mutation_p.A315S|CA10_uc002ity.3_Missense_Mutation_p.A315S|CA10_uc002itz.2_Missense_Mutation_p.A315S	NM_020178	NP_064563	Q9NS85	CAH10_HUMAN	carbonic anhydrase X	315					brain development					ovary(1)|skin(1)	2			BRCA - Breast invasive adenocarcinoma(22;4.74e-06)			AGCTTCTGGGCTCGGTTGTTT	0.512			NA											6	100					5.4927e-09	7.99815e-09	0.004482	1	0
TANC2	26115	broad.mit.edu	37	17	61498459	61498459	+	Nonsense_Mutation	SNP	C	C	T			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr17:61498459C>T	uc002jal.3	+	25	5139	c.5116C>T	c.(5116-5118)CGA>TGA	p.R1706*	TANC2_uc010wpe.1_3'UTR|TANC2_uc002jao.3_Nonsense_Mutation_p.R817*	NM_025185	NP_079461	Q9HCD6	TANC2_HUMAN	tetratricopeptide repeat, ankyrin repeat and	1706							binding			ovary(2)	2						CTCAGCATACCGAGGTGGCGT	0.567			NA											19	279					0	0	0.007413	0	0
ABCA9	10350	broad.mit.edu	37	17	66986013	66986013	+	Missense_Mutation	SNP	C	C	A	rs149991432		TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr17:66986013C>A	uc002jhu.2	-	30	4039	c.3896G>T	c.(3895-3897)TGC>TTC	p.C1299F	ABCA9_uc010dez.2_Missense_Mutation_p.C1261F	NM_080283	NP_525022	Q8IUA7	ABCA9_HUMAN	ATP-binding cassette, sub-family A, member 9	1299	ABC transporter 2.				transport	integral to membrane	ATP binding|ATPase activity			ovary(4)|upper_aerodigestive_tract(1)|central_nervous_system(1)	6	Breast(10;1.47e-12)					TTTAGAAAAGCAATTTTTCTT	0.358			NA											13	106					7.03913e-09	1.01432e-08	0.001368	1	0
ABCA5	23461	broad.mit.edu	37	17	67243691	67243691	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr17:67243691C>T	uc002jif.2	-	38	6134	c.4916G>A	c.(4915-4917)AGA>AAA	p.R1639K	ABCA10_uc010dfa.1_5'Flank|ABCA5_uc002jib.2_Missense_Mutation_p.R605K|ABCA5_uc002jic.2_Missense_Mutation_p.R862K|ABCA5_uc002jid.2_Missense_Mutation_p.R556K|ABCA5_uc002jie.2_RNA|ABCA5_uc002jig.2_Missense_Mutation_p.R1639K	NM_018672	NP_061142	Q8WWZ7	ABCA5_HUMAN	ATP-binding cassette, sub-family A , member 5	1639					cholesterol efflux|high-density lipoprotein particle remodeling|negative regulation of macrophage derived foam cell differentiation	Golgi membrane|integral to membrane|late endosome membrane|lysosomal membrane	ATP binding|ATPase activity			ovary(2)|central_nervous_system(1)|skin(1)	4	Breast(10;3.72e-11)					AAATACTACTCTATCTTCTTG	0.333			NA											8	108					0	0	0.004482	0	0
ABCA5	23461	broad.mit.edu	37	17	67309240	67309240	+	Silent	SNP	T	T	C	rs146635038		TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr17:67309240T>C	uc002jif.2	-	2	1518	c.300A>G	c.(298-300)CTA>CTG	p.L100L	ABCA5_uc002jig.2_Silent_p.L100L|ABCA5_uc002jih.2_Silent_p.L100L|ABCA5_uc010dfe.2_Silent_p.L100L	NM_018672	NP_061142	Q8WWZ7	ABCA5_HUMAN	ATP-binding cassette, sub-family A , member 5	100					cholesterol efflux|high-density lipoprotein particle remodeling|negative regulation of macrophage derived foam cell differentiation	Golgi membrane|integral to membrane|late endosome membrane|lysosomal membrane	ATP binding|ATPase activity			ovary(2)|central_nervous_system(1)|skin(1)	4	Breast(10;3.72e-11)					TACCATCAGGTAGATGATCAG	0.313			NA											5	66					0	0	0.000602	0	0
P4HB	5034	broad.mit.edu	37	17	79813036	79813036	+	Silent	SNP	C	C	A			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr17:79813036C>A	uc002kbn.1	-	4	803	c.606G>T	c.(604-606)GGG>GGT	p.G202G	P4HB_uc002kbm.1_5'UTR	NM_000918	NP_000909	P07237	PDIA1_HUMAN	prolyl 4-hydroxylase, beta subunit precursor	202					cell redox homeostasis|glycerol ether metabolic process|lipid metabolic process|lipoprotein metabolic process|peptidyl-proline hydroxylation to 4-hydroxy-L-proline	cell surface|endoplasmic reticulum lumen|ER-Golgi intermediate compartment|extracellular region|melanosome|plasma membrane	electron carrier activity|procollagen-proline 4-dioxygenase activity|protein disulfide isomerase activity|protein disulfide oxidoreductase activity				0	all_neural(118;0.0878)|Ovarian(332;0.12)		BRCA - Breast invasive adenocarcinoma(99;0.013)|OV - Ovarian serous cystadenocarcinoma(97;0.0509)			AGAGGACAACCCCATCTTTGT	0.527	Colon(49;444 983 1296 7887 42561)		NA											49	287					2.81731e-22	5.29042e-22	0.00361	1	0
FAM38B	63895	broad.mit.edu	37	18	10680359	10680359	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr18:10680359G>T	uc002kor.3	-	10	1461	c.1321C>A	c.(1321-1323)CAA>AAA	p.Q441K	FAM38B_uc002koq.2_Missense_Mutation_p.Q276K	NM_022068	NP_071351	Q9H5I5	PIEZ2_HUMAN	family with sequence similarity 38, member B	2484						integral to membrane	ion channel activity			ovary(1)	1						TCCAGAAATTGCATAGCACCC	0.378			NA											6	91					0.00307968	0.00337221	0.00308	1	0
CEP192	55125	broad.mit.edu	37	18	13095519	13095519	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr18:13095519G>T	uc010xac.1	+	35	6352	c.6272G>T	c.(6271-6273)GGG>GTG	p.G2091V	CEP192_uc010dlf.1_RNA|CEP192_uc010xad.1_Missense_Mutation_p.G1616V|CEP192_uc002kru.2_RNA|CEP192_uc002krv.2_Missense_Mutation_p.G513V|CEP192_uc002krw.2_Missense_Mutation_p.G240V|CEP192_uc002krx.2_Missense_Mutation_p.G95V|CEP192_uc002kry.2_RNA	NM_032142	NP_115518	E9PF99	E9PF99_HUMAN	centrosomal protein 192kDa	2091										ovary(4)|pancreas(1)	5						GGAGCTTCTGGGAAACATGGT	0.438			NA											93	224					4.98208e-43	9.79887e-43	0.00361	1	0
DSG3	1830	broad.mit.edu	37	18	29054280	29054280	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr18:29054280G>T	uc002kws.2	+	15	2407	c.2298G>T	c.(2296-2298)ATG>ATT	p.M766I	DSG3_uc002kwt.2_Missense_Mutation_p.M48I	NM_001944	NP_001935	P32926	DSG3_HUMAN	desmoglein 3 preproprotein	766	Cytoplasmic (Potential).				cellular component disassembly involved in apoptosis|homophilic cell adhesion	cytosol|desmosome|integral to membrane	calcium ion binding			skin(4)|ovary(3)|lung(1)|central_nervous_system(1)	9			OV - Ovarian serous cystadenocarcinoma(10;0.00504)			CTGGAACCATGAGAACAAGGC	0.507			NA											20	112					4.96729e-08	6.84859e-08	0.008871	1	0
ZCCHC2	54877	broad.mit.edu	37	18	60243765	60243765	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr18:60243765G>C	uc002lip.3	+	14	3490	c.3490G>C	c.(3490-3492)GCA>CCA	p.A1164P	ZCCHC2_uc002lio.2_RNA|ZCCHC2_uc002liq.2_Missense_Mutation_p.A634P	NM_017742	NP_060212	Q9C0B9	ZCHC2_HUMAN	zinc finger, CCHC domain containing 2	1164					cell communication	cytoplasm	nucleic acid binding|phosphatidylinositol binding|zinc ion binding			lung(1)|prostate(1)	2						ACTGAGATACGCACCTCCCCT	0.473			NA											3	30					0	0	0.009096	0	0
TSHZ1	10194	broad.mit.edu	37	18	72998565	72998565	+	Silent	SNP	C	C	G			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr18:72998565C>G	uc002lly.2	+	2	1631	c.1068C>G	c.(1066-1068)GGC>GGG	p.G356G		NM_005786	NP_005777	Q6ZSZ6	TSH1_HUMAN	teashirt family zinc finger 1	401						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Esophageal squamous(42;0.129)|Prostate(75;0.142)|Melanoma(33;0.211)		Colorectal(1;0.000501)|READ - Rectum adenocarcinoma(2;0.00226)|BRCA - Breast invasive adenocarcinoma(31;0.246)		ACCAGAATGGCGCCAGCTACA	0.612			NA											5	53					0	0	0.001984	0	0
MIER2	54531	broad.mit.edu	37	19	313534	313534	+	Silent	SNP	C	C	G			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr19:313534C>G	uc002lok.1	-	8	774	c.765G>C	c.(763-765)GGG>GGC	p.G255G		NM_017550	NP_060020	Q8N344	MIER2_HUMAN	mesoderm induction early response 1, family	255	ELM2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding				0		all_cancers(10;1.05e-30)|all_epithelial(18;3.04e-19)|Acute lymphoblastic leukemia(61;4.36e-14)|all_hematologic(61;4.84e-09)|Lung NSC(49;2.49e-05)|all_lung(49;4.36e-05)|Breast(49;0.000304)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GGAGCTGAGGCCCGGCCATCT	0.677			NA											7	110					0	0	0.00308	0	0
TLE6	79816	broad.mit.edu	37	19	2989238	2989238	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr19:2989238G>T	uc002lwu.2	+	11	951	c.551G>T	c.(550-552)AGA>ATA	p.R184I	TLE6_uc002lwt.2_Missense_Mutation_p.R307I|TLE6_uc010dtg.2_Missense_Mutation_p.R307I|TLE6_uc002lwv.2_Missense_Mutation_p.R88I	NM_024760	NP_079036	Q9H808	TLE6_HUMAN	transducin-like enhancer of split 6 isoform 2	184	WD 1.				regulation of transcription, DNA-dependent	nucleus				ovary(1)	1				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TGTGGCAGAAGAGGCATCAAG	0.602			NA											4	46					0.00909568	0.00975377	0.009096	1	0
XAB2	56949	broad.mit.edu	37	19	7684528	7684528	+	Silent	SNP	G	G	T			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr19:7684528G>T	uc002mgx.2	-	19	2538	c.2512C>A	c.(2512-2514)CGG>AGG	p.R838R		NM_020196	NP_064581	Q9HCS7	SYF1_HUMAN	XPA binding protein 2	838					transcription, DNA-dependent|transcription-coupled nucleotide-excision repair	catalytic step 2 spliceosome|nucleoplasm	protein binding			central_nervous_system(2)|breast(1)|skin(1)	4						TGCTCCAGCCGAACCTCTGTG	0.701			NA						Direct_reversal_of_damage|NER					4	35					1.23904e-05	1.5488e-05	0.000602	1	0
MUC16	94025	broad.mit.edu	37	19	9064438	9064438	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr19:9064438G>T	uc002mkp.2	-	3	23212	c.23008C>A	c.(23008-23010)CCT>ACT	p.P7670T		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	7672	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						ACACCTCCAGGACCTCTGCCC	0.527			NA											6	62					0.00198382	0.00218378	0.001984	1	0
MUC16	94025	broad.mit.edu	37	19	9064463	9064463	+	Silent	SNP	C	C	T			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr19:9064463C>T	uc002mkp.2	-	3	23187	c.22983G>A	c.(22981-22983)GAG>GAA	p.E7661E		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	7663	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						AAGTGGTCATCTCTGGGTGTG	0.517			NA											6	59					0	0	0.001984	0	0
MUC16	94025	broad.mit.edu	37	19	9073402	9073402	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr19:9073402G>T	uc002mkp.2	-	3	14248	c.14044C>A	c.(14044-14046)CAG>AAG	p.Q4682K		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	4684	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GACCCTGTCTGGGTGGTGGTC	0.483			NA											37	191					1.49673e-21	2.7854e-21	0.00623	1	0
TRMT1	55621	broad.mit.edu	37	19	13223573	13223573	+	Silent	SNP	C	C	A	rs147062421	byFrequency	TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr19:13223573C>A	uc002mwj.2	-	6	1066	c.816G>T	c.(814-816)ACG>ACT	p.T272T	TRMT1_uc002mwk.2_Silent_p.T272T|TRMT1_uc002mwl.3_Silent_p.T272T|TRMT1_uc010xmz.1_Silent_p.T58T	NM_017722	NP_060192	Q9NXH9	TRM1_HUMAN	tRNA methyltransferase 1 isoform 1	272							RNA binding|tRNA (guanine-N2-)-methyltransferase activity|zinc ion binding			ovary(1)|pancreas(1)	2			OV - Ovarian serous cystadenocarcinoma(19;6.08e-22)	GBM - Glioblastoma multiforme(1328;0.0356)		TGCTGTAGCACGTCTCCCCGC	0.667			NA											8	53					1.12685e-05	1.42141e-05	0.004482	1	0
SLC27A1	376497	broad.mit.edu	37	19	17599848	17599848	+	Silent	SNP	C	C	T			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr19:17599848C>T	uc002ngu.1	+	6	968	c.918C>T	c.(916-918)ATC>ATT	p.I306I	SLC27A1_uc002ngt.1_Silent_p.I38I|SLC27A1_uc010xpp.1_Silent_p.I127I	NM_198580	NP_940982	Q6PCB7	S27A1_HUMAN	solute carrier family 27, member 1	306	Sufficient for oligomerization (By similarity).|Cytoplasmic (Potential).				cardiolipin biosynthetic process|fatty acid metabolic process|long-chain fatty acid transport|negative regulation of phospholipid biosynthetic process|phosphatidic acid biosynthetic process|phosphatidylcholine biosynthetic process|phosphatidylethanolamine biosynthetic process|phosphatidylinositol biosynthetic process|phosphatidylserine biosynthetic process|transmembrane transport	endomembrane system|integral to membrane	fatty acid transporter activity|nucleotide binding				0						AGTGTCTCATCTATGGGCTGA	0.557			NA											8	53					0	0	0.004482	0	0
ZNF492	57615	broad.mit.edu	37	19	22847799	22847799	+	Missense_Mutation	SNP	A	A	G			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr19:22847799A>G	uc002nqw.3	+	4	1572	c.1328A>G	c.(1327-1329)CAT>CGT	p.H443R		NM_020855	NP_065906	Q9P255	ZN492_HUMAN	zinc finger protein 492	443	C2H2-type 11.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_cancers(12;0.0266)|all_lung(12;0.00187)|Lung NSC(12;0.0019)|all_epithelial(12;0.00203)|Hepatocellular(1079;0.244)				AAGGTAATTCATACTGGAGAG	0.378			NA											7	38					0	0	0.001984	0	0
TSHZ3	57616	broad.mit.edu	37	19	31768256	31768256	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr19:31768256G>T	uc002nsy.3	-	2	2508	c.2443C>A	c.(2443-2445)CCG>ACG	p.P815T		NM_020856	NP_065907	Q63HK5	TSH3_HUMAN	zinc finger protein 537	815					negative regulation of transcription, DNA-dependent|regulation of respiratory gaseous exchange by neurological system process	growth cone|nucleus	chromatin binding|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)|skin(2)|pancreas(1)|lung(1)	8	Esophageal squamous(110;0.226)					GAGGTTGCCGGGGCTGTGGAC	0.532			NA											20	82					1.10513e-12	1.81996e-12	0.002299	1	0
GPI	2821	broad.mit.edu	37	19	34859562	34859562	+	Missense_Mutation	SNP	G	G	T	rs11548996		TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr19:34859562G>T	uc002nvg.1	+	4	460	c.357G>T	c.(355-357)ATG>ATT	p.M119I	GPI_uc002nvf.2_Missense_Mutation_p.M158I|GPI_uc010xrv.1_Missense_Mutation_p.M158I|GPI_uc010xrw.1_Missense_Mutation_p.M119I|GPI_uc010edl.1_Missense_Mutation_p.M119I|GPI_uc002nvh.1_3'UTR	NM_000175	NP_000166	P06744	G6PI_HUMAN	glucose phosphate isomerase	119					angiogenesis|gluconeogenesis|glycolysis|hemostasis|humoral immune response	cytosol|extracellular space|nucleus|plasma membrane	cytokine activity|glucose-6-phosphate isomerase activity|growth factor activity			ovary(1)|kidney(1)	2	Esophageal squamous(110;0.162)					AGGATGTGATGCCAGAGGTCA	0.552			NA											13	81					9.05144e-12	1.45595e-11	0.001855	1	0
ATP1A3	478	broad.mit.edu	37	19	42480646	42480646	+	Silent	SNP	C	C	T			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr19:42480646C>T	uc002osg.2	-	15	2170	c.2016G>A	c.(2014-2016)CTG>CTA	p.L672L	ATP1A3_uc010xwf.1_Silent_p.L683L|ATP1A3_uc010xwg.1_Silent_p.L642L|ATP1A3_uc010xwh.1_Silent_p.L685L|ATP1A3_uc002osh.2_Silent_p.L672L	NM_152296	NP_689509	P13637	AT1A3_HUMAN	Na+/K+ -ATPase alpha 3 subunit	672	Cytoplasmic (Potential).				ATP biosynthetic process	endoplasmic reticulum|Golgi apparatus	ATP binding|metal ion binding|sodium:potassium-exchanging ATPase activity			ovary(1)|pancreas(1)	2						TGTGATTCTGCAGGATCTCGT	0.597			NA											14	77					0	0	0.004007	0	0
SHANK1	50944	broad.mit.edu	37	19	51220030	51220030	+	Silent	SNP	A	A	G			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr19:51220030A>G	uc002psx.1	-	1	166	c.147T>C	c.(145-147)GGT>GGC	p.G49G		NM_016148	NP_057232	Q9Y566	SHAN1_HUMAN	SH3 and multiple ankyrin repeat domains 1	49					cytoskeletal anchoring at plasma membrane	cell junction|cytoplasm|dendrite|membrane fraction|postsynaptic density|postsynaptic membrane	ionotropic glutamate receptor binding			large_intestine(2)	2		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00493)|GBM - Glioblastoma multiforme(134;0.0199)		AGGCCAGGCTACCAGGTGCCC	0.692			NA											14	37					0	0	0.004007	0	0
ZNF813	126017	broad.mit.edu	37	19	53994225	53994225	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr19:53994225G>T	uc002qbu.2	+	4	867	c.739G>T	c.(739-741)GTA>TTA	p.V247L	ZNF813_uc010eqq.1_Intron	NM_001004301	NP_001004301	Q6ZN06	ZN813_HUMAN	zinc finger protein 813	247	C2H2-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)	1				GBM - Glioblastoma multiforme(134;0.00619)		TAAATGTGATGTATGTGGCAA	0.393			NA											15	75					0.00498961	0.00540649	0.00499	1	0
PRKCG	5582	broad.mit.edu	37	19	54396639	54396639	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr19:54396639G>T	uc002qcq.1	+	9	1215	c.933G>T	c.(931-933)TTG>TTT	p.L311F	PRKCG_uc010eqz.1_Missense_Mutation_p.L311F|PRKCG_uc010yef.1_Missense_Mutation_p.C282F|PRKCG_uc010yeg.1_Missense_Mutation_p.L311F|PRKCG_uc010yeh.1_Missense_Mutation_p.L198F	NM_002739	NP_002730	P05129	KPCG_HUMAN	protein kinase C, gamma	311					activation of phospholipase C activity|cell death|intracellular signal transduction|negative regulation of protein catabolic process|negative regulation of protein ubiquitination|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of mismatch repair|synaptic transmission	cytosol	ATP binding|protein kinase C activity|zinc ion binding			lung(4)|ovary(2)|pancreas(2)|large_intestine(1)	9	all_cancers(19;0.0462)|all_epithelial(19;0.0258)|all_lung(19;0.185)|Ovarian(34;0.19)|Lung NSC(19;0.218)			GBM - Glioblastoma multiforme(134;0.0521)		CCCTGGAATTGTATGAGGTGA	0.507			NA											13	63					1.36491e-13	2.31199e-13	0.001855	1	0
LILRB5	10990	broad.mit.edu	37	19	54760185	54760185	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr19:54760185G>T	uc002qex.2	-	4	487	c.376C>A	c.(376-378)CTT>ATT	p.L126I	LILRA6_uc002qew.1_Intron|LILRB5_uc010yer.1_Intron|LILRB5_uc002qey.2_Missense_Mutation_p.L126I|LILRB5_uc002qez.2_Intron|LILRB5_uc002qfa.1_Intron|LILRB5_uc010yes.1_Intron	NM_006840	NP_006831	O75023	LIRB5_HUMAN	leukocyte immunoglobulin-like receptor,	126	Extracellular (Potential).|Ig-like C2-type 2.				cell surface receptor linked signaling pathway|defense response	integral to membrane	transmembrane receptor activity			ovary(1)|pancreas(1)	2	all_cancers(19;0.00681)|all_epithelial(19;0.00368)|all_lung(19;0.016)|Lung NSC(19;0.0296)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		AGGGCTAAAAGAGTGGGTTCT	0.552			NA											21	88					1.22574e-08	1.75407e-08	0.002299	1	0
LILRA3	11026	broad.mit.edu	37	19	54801976	54801976	+	Silent	SNP	G	G	A			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr19:54801976G>A	uc002qfd.2	-	6	1277	c.1212C>T	c.(1210-1212)AAC>AAT	p.N404N	LILRA6_uc002qew.1_Intron|LILRA3_uc010erk.2_Silent_p.N340N	NM_006865	NP_006856	Q8N6C8	LIRA3_HUMAN	leukocyte immunoglobulin-like receptor,	404	Ig-like C2-type 4.				defense response	extracellular region|plasma membrane	antigen binding|receptor activity			ovary(1)	1	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		GCAGGTAGGGGTTGGAGCTGA	0.617			NA											19	186					0	0	0.001882	0	0
NLRP2	55655	broad.mit.edu	37	19	55501959	55501959	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr19:55501959C>A	uc002qij.2	+	10	2713	c.2627C>A	c.(2626-2628)GCC>GAC	p.A876D	NLRP2_uc010yfp.1_Missense_Mutation_p.A853D|NLRP2_uc010esn.2_Missense_Mutation_p.A852D|NLRP2_uc010eso.2_Missense_Mutation_p.A873D|NLRP2_uc010esp.2_Missense_Mutation_p.A854D	NM_017852	NP_060322	Q9NX02	NALP2_HUMAN	NLR family, pyrin domain containing 2	876	LRR 3.				apoptosis|positive regulation of caspase activity|positive regulation of interleukin-1 beta secretion	cytoplasm	ATP binding|Pyrin domain binding			ovary(1)|skin(1)	2			BRCA - Breast invasive adenocarcinoma(297;0.163)	GBM - Glioblastoma multiforme(193;0.028)		CTGTGCTTGGCCAAGAACCCC	0.522			NA											8	123					5.4927e-09	7.99815e-09	0.004482	1	0
APOB	338	broad.mit.edu	37	2	21235206	21235206	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr2:21235206C>A	uc002red.2	-	26	4662	c.4534G>T	c.(4534-4536)GGC>TGC	p.G1512C		NM_000384	NP_000375	P04114	APOB_HUMAN	apolipoprotein B precursor	1512					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			ovary(11)|skin(9)|central_nervous_system(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	TTGAGCCGGCCAGTGTTAGGA	0.478			NA											12	79					5.50884e-06	7.01278e-06	0.001368	1	0
ASXL2	55252	broad.mit.edu	37	2	25967101	25967101	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr2:25967101C>T	uc002rgs.2	-	12	2326	c.2105G>A	c.(2104-2106)GGA>GAA	p.G702E	ASXL2_uc002rgt.1_Missense_Mutation_p.G442E	NM_018263	NP_060733	Q76L83	ASXL2_HUMAN	additional sex combs like 2	702	Gly-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|protein binding			pancreas(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					ACCACCCTCTCCTGGACCTTG	0.642			NA											13	178					0	0	0.003163	0	0
RASGRP3	25780	broad.mit.edu	37	2	33747045	33747045	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr2:33747045G>A	uc002rox.2	+	8	1019	c.392G>A	c.(391-393)AGA>AAA	p.R131K	RASGRP3_uc010ync.1_Missense_Mutation_p.R131K|RASGRP3_uc002roy.2_Missense_Mutation_p.R131K	NM_170672	NP_733772	Q8IV61	GRP3_HUMAN	RAS guanyl releasing protein 3 (calcium and	131					MAPKKK cascade|small GTPase mediated signal transduction	integral to plasma membrane|intracellular	calcium ion binding|diacylglycerol binding|guanyl-nucleotide exchange factor activity|protein binding|Rap GTPase activator activity|signal transducer activity			lung(3)|ovary(1)|pancreas(1)	5	all_hematologic(175;0.115)					TGGATGAGAAGAGTCACACAG	0.438			NA											15	124					0	0	0.00245	0	0
LRPPRC	10128	broad.mit.edu	37	2	44204192	44204192	+	Splice_Site	SNP	C	C	T			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr2:44204192C>T	uc002rtr.2	-	5	650	c.592_splice	c.e5-1	p.V198_splice	LRPPRC_uc010yob.1_Splice_Site_p.V98_splice|LRPPRC_uc010faw.1_Splice_Site_p.V172_splice	NM_133259	NP_573566	P42704	LPPRC_HUMAN	leucine-rich PPR motif-containing protein						mitochondrion transport along microtubule|mRNA transport|regulation of transcription, DNA-dependent|transcription, DNA-dependent	condensed nuclear chromosome|cytoskeleton|mitochondrial nucleoid|nuclear inner membrane|nuclear outer membrane|nucleoplasm|perinuclear region of cytoplasm	beta-tubulin binding|microtubule binding|RNA binding			ovary(2)|skin(1)	3		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)				GGTATGTCACCTGTCAATGAA	0.313			NA											5	39					0	0	0.001984	0	0
AFTPH	54812	broad.mit.edu	37	2	64779295	64779295	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr2:64779295G>T	uc002sdc.2	+	1	719	c.687G>T	c.(685-687)GAG>GAT	p.E229D	AFTPH_uc002scz.2_Missense_Mutation_p.E229D|AFTPH_uc002sda.2_Missense_Mutation_p.E229D|AFTPH_uc002sdb.2_Missense_Mutation_p.E229D	NM_203437	NP_982261	Q6ULP2	AFTIN_HUMAN	aftiphilin protein isoform a	229					protein transport	AP-1 adaptor complex|cytosol|nucleus	clathrin binding			ovary(2)	2						GTCCTGCTGAGGAATTTGCAG	0.393			NA											20	68					1.22574e-08	1.75407e-08	0.002299	1	0
MOGS	7841	broad.mit.edu	37	2	74688860	74688860	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr2:74688860C>T	uc010ffj.2	-	4	2219	c.2056G>A	c.(2056-2058)GTA>ATA	p.V686I	MOGS_uc010ffh.2_Missense_Mutation_p.V411I|MOGS_uc010yrt.1_Missense_Mutation_p.V567I|MOGS_uc010ffi.2_Missense_Mutation_p.V580I	NM_006302	NP_006293	Q13724	MOGS_HUMAN	mannosyl-oligosaccharide glucosidase isoform 1	686	Lumenal (Potential).				oligosaccharide metabolic process|post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane|integral to membrane|membrane fraction	mannosyl-oligosaccharide glucosidase activity				0						AGAGCATCTACATACTGCAGT	0.592			NA											16	131					0	0	0.006122	0	0
LRRTM1	347730	broad.mit.edu	37	2	80530299	80530299	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr2:80530299G>T	uc002sok.1	-	2	916	c.646C>A	c.(646-648)CTC>ATC	p.L216I	CTNNA2_uc010yse.1_Intron|CTNNA2_uc010ysf.1_Intron|CTNNA2_uc010ysg.1_Intron|CTNNA2_uc010ysh.1_Intron|CTNNA2_uc010ysi.1_5'Flank|LRRTM1_uc002soj.3_RNA	NM_178839	NP_849161	Q86UE6	LRRT1_HUMAN	leucine rich repeat transmembrane neuronal 1	216	LRR 6.|Lumenal (Potential).					axon|endoplasmic reticulum membrane|growth cone|integral to membrane				ovary(3)|upper_aerodigestive_tract(1)|skin(1)	5						TTGTGCTCGAGGTGCAGCTCG	0.582			NA								HNSCC(69;0.2)			31	164					4.31634e-10	6.56146e-10	0.002445	1	0
DDX11L2	84771	broad.mit.edu	37	2	114357557	114357557	+	Nonstop_Mutation	SNP	A	A	G	rs115341812	by1000genomes	TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr2:114357557A>G	uc010yxx.1	-	3	709	c.382T>C	c.(382-384)TAG>CAG	p.*128Q						SubName: Full=DEAD/H box polypeptide 11 like 2;												0						GCCTACTTCTAGTGAAACTGG	0.567			NA											3	23					0	0	0.004672	0	0
LRP1B	53353	broad.mit.edu	37	2	140992421	140992421	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr2:140992421G>T	uc002tvj.1	-	90	14565	c.13593C>A	c.(13591-13593)TTC>TTA	p.F4531L		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	4531	Cytoplasmic (Potential).				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		gtggaagcttgaaagcactgg	0.05	Colon(99;50 2074 2507 20106)		NA								TSP Lung(27;0.18)			16	44					8.34094e-07	1.09889e-06	0.008871	1	0
NEB	4703	broad.mit.edu	37	2	152527689	152527689	+	Missense_Mutation	SNP	T	T	C			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr2:152527689T>C	uc010fnx.2	-	38	4545	c.4354A>G	c.(4354-4356)ATT>GTT	p.I1452V		NM_004543	NP_004534	P20929	NEBU_HUMAN	nebulin isoform 3	1452	Nebulin 37.				muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			ovary(8)|large_intestine(5)|breast(3)|central_nervous_system(2)|skin(1)|pancreas(1)	20				BRCA - Breast invasive adenocarcinoma(221;0.219)		AGGGAACCAATAGGGATCCAT	0.448			NA											13	45					0	0	0.004007	0	0
TBR1	10716	broad.mit.edu	37	2	162274750	162274750	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr2:162274750G>A	uc002ubw.1	+	3	1188	c.886G>A	c.(886-888)GGG>AGG	p.G296R	TBR1_uc010foy.2_Missense_Mutation_p.G9R	NM_006593	NP_006584	Q16650	TBR1_HUMAN	T-box, brain, 1	296	T-box.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|central_nervous_system(1)	2						CCCCAACACTGGGGCTCACTG	0.478			NA											20	77					0	0	0.010504	0	0
KCNH7	90134	broad.mit.edu	37	2	163374483	163374483	+	Missense_Mutation	SNP	T	T	C			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr2:163374483T>C	uc002uch.1	-	4	861	c.649A>G	c.(649-651)AAA>GAA	p.K217E	KCNH7_uc002uci.2_Missense_Mutation_p.K217E	NM_033272	NP_150375	Q9NS40	KCNH7_HUMAN	potassium voltage-gated channel, subfamily H,	217	Cytoplasmic (Potential).				regulation of transcription, DNA-dependent	integral to membrane	protein binding|signal transducer activity			ovary(3)|skin(2)	5					Ibutilide(DB00308)	ATCAAAGCTTTTGTGTCATCT	0.458	GBM(196;1492 2208 17507 24132 45496)		NA											19	142					0	0	0.007413	0	0
SCN3A	6328	broad.mit.edu	37	2	166019136	166019136	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr2:166019136C>A	uc002ucx.2	-	8	1389	c.897G>T	c.(895-897)ATG>ATT	p.M299I	SCN3A_uc002ucy.2_Missense_Mutation_p.M299I|SCN3A_uc002ucz.2_Missense_Mutation_p.M299I|SCN3A_uc002uda.1_Missense_Mutation_p.M168I|SCN3A_uc002udb.1_Missense_Mutation_p.M168I	NM_006922	NP_008853	Q9NY46	SCN3A_HUMAN	sodium channel, voltage-gated, type III, alpha	299						voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(4)|breast(3)|skin(2)|central_nervous_system(1)	10					Lamotrigine(DB00555)	CATTTGAATCCATTGTGCCAT	0.388			NA											7	93					0.00198382	0.00218378	0.001984	1	0
XIRP2	129446	broad.mit.edu	37	2	168102744	168102744	+	Silent	SNP	C	C	A			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr2:168102744C>A	uc002udx.2	+	8	4860	c.4842C>A	c.(4840-4842)TCC>TCA	p.S1614S	XIRP2_uc010fpn.2_Intron|XIRP2_uc010fpo.2_Intron|XIRP2_uc010fpp.2_Intron|XIRP2_uc002udy.2_Silent_p.S1439S|XIRP2_uc010fpq.2_Silent_p.S1392S|XIRP2_uc010fpr.2_Intron|XIRP2_uc010fps.1_5'Flank	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	1439					actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14						ACCTACTTTCCAAAAGGGACT	0.338			NA											6	57					1.76689e-08	2.5026e-08	0.006214	1	0
TTN	7273	broad.mit.edu	37	2	179397726	179397726	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr2:179397726G>T	uc010zfg.1	-	307	96136	c.95912C>A	c.(95911-95913)CCT>CAT	p.P31971H	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.P25666H|TTN_uc010zfi.1_Missense_Mutation_p.P25599H|TTN_uc010zfj.1_Missense_Mutation_p.P25474H	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	32898							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TACATCATAAGGCATCCGGAG	0.448			NA											55	275					1.83081e-24	3.48525e-24	0.00361	1	0
TTN	7273	broad.mit.edu	37	2	179412988	179412988	+	Missense_Mutation	SNP	A	A	T			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr2:179412988A>T	uc010zfg.1	-	288	85885	c.85661T>A	c.(85660-85662)GTT>GAT	p.V28554D	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.V22249D|TTN_uc010zfi.1_Missense_Mutation_p.V22182D|TTN_uc010zfj.1_Missense_Mutation_p.V22057D	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	29481							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AGTATCAACAACATCAAGTCT	0.483			NA											10	184					0	0	0.000978	0	0
ITGA4	3676	broad.mit.edu	37	2	182359483	182359483	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr2:182359483G>C	uc002unu.2	+	12	2046	c.1283G>C	c.(1282-1284)AGT>ACT	p.S428T		NM_000885	NP_000876	P13612	ITA4_HUMAN	integrin alpha 4 precursor	428	FG-GAP 7.|Extracellular (Potential).				blood coagulation|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|regulation of immune response	integrin complex	identical protein binding|receptor activity			ovary(3)|lung(1)|central_nervous_system(1)|pancreas(1)	6			OV - Ovarian serous cystadenocarcinoma(117;0.0593)		Natalizumab(DB00108)	AAATCGTTAAGTATGTTTGGA	0.313			NA											30	109					0	0	0.004289	0	0
PDE1A	5136	broad.mit.edu	37	2	183051238	183051238	+	Nonsense_Mutation	SNP	C	C	A			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr2:183051238C>A	uc002uos.2	-	13	1417	c.1333G>T	c.(1333-1335)GAG>TAG	p.E445*	PDE1A_uc010zfp.1_Nonsense_Mutation_p.E341*|PDE1A_uc002uoq.1_Nonsense_Mutation_p.E445*|PDE1A_uc010zfq.1_Nonsense_Mutation_p.E445*|PDE1A_uc002uor.2_Nonsense_Mutation_p.E429*|PDE1A_uc002uou.2_Nonsense_Mutation_p.E411*	NM_001003683	NP_001003683	P54750	PDE1A_HUMAN	phosphodiesterase 1A isoform 2	445	Catalytic (By similarity).				activation of phospholipase C activity|nerve growth factor receptor signaling pathway|platelet activation	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|calmodulin binding|calmodulin-dependent cyclic-nucleotide phosphodiesterase activity|metal ion binding			skin(2)|ovary(1)	3			OV - Ovarian serous cystadenocarcinoma(117;0.061)			GAGGCTTCCTCTATAAGAGGA	0.348			NA											5	58					8.12818e-05	9.77738e-05	0.001984	1	0
COL3A1	1281	broad.mit.edu	37	2	189868184	189868184	+	Silent	SNP	T	T	C			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr2:189868184T>C	uc002uqj.1	+	37	2718	c.2601T>C	c.(2599-2601)GGT>GGC	p.G867G		NM_000090	NP_000081	P02461	CO3A1_HUMAN	collagen type III alpha 1 preproprotein	867	Triple-helical region.				axon guidance|cell-matrix adhesion|collagen biosynthetic process|collagen fibril organization|fibril organization|heart development|integrin-mediated signaling pathway|negative regulation of immune response|peptide cross-linking|platelet activation|response to cytokine stimulus|response to radiation|skin development|transforming growth factor beta receptor signaling pathway	collagen type III|extracellular space	extracellular matrix structural constituent|integrin binding|platelet-derived growth factor binding			central_nervous_system(7)|ovary(4)|large_intestine(2)	13			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.141)		Collagenase(DB00048)|Palifermin(DB00039)	GCAGTCCTGGTGGACCTGTAA	0.378			NA											6	40					0	0	0.001984	0	0
INO80D	54891	broad.mit.edu	37	2	206869874	206869874	+	Missense_Mutation	SNP	T	T	A			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr2:206869874T>A	uc002vaz.3	-	11	2707	c.2302A>T	c.(2302-2304)ACT>TCT	p.T768S		NM_017759	NP_060229	Q53TQ3	IN80D_HUMAN	INO80 complex subunit D	768					DNA recombination|DNA repair|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				ovary(1)	1						CTGATCAGAGTGGCAGAAGTA	0.597			NA											6	88					0	0	0.001984	0	0
VWC2L	402117	broad.mit.edu	37	2	215279062	215279062	+	Silent	SNP	C	C	A			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr2:215279062C>A	uc002vet.2	+	2	275	c.145C>A	c.(145-147)CGA>AGA	p.R49R	VWC2L_uc010zjl.1_Silent_p.R49R	NM_001080500	NP_001073969	B2RUY7	VWC2L_HUMAN	von Willebrand factor C domain-containing	49						extracellular region					0						TGATGACTATCGAGGGAAAGG	0.478			NA											6	29					1.06961e-07	1.45062e-07	0.00308	1	0
CYP27A1	1593	broad.mit.edu	37	2	219674425	219674425	+	Silent	SNP	G	G	T			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr2:219674425G>T	uc002viz.3	+	2	815	c.381G>T	c.(379-381)CGG>CGT	p.R127R		NM_000784	NP_000775	Q02318	CP27A_HUMAN	cytochrome P450, family 27, subfamily A,	127					bile acid biosynthetic process|xenobiotic metabolic process	mitochondrial matrix	cholestanetriol 26-monooxygenase activity|electron carrier activity|heme binding			ovary(1)	1		Renal(207;0.0474)		Epithelial(149;9.48e-07)|all cancers(144;0.000171)|LUSC - Lung squamous cell carcinoma(224;0.00813)|Lung(261;0.00981)	Cholecalciferol(DB00169)	ACCCAGTACGGAACGACATGG	0.607			NA											13	107					4.93089e-13	8.21815e-13	0.00245	1	0
OTOS	150677	broad.mit.edu	37	2	241078631	241078631	+	Silent	SNP	G	G	A			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr2:241078631G>A	uc002vyv.2	-	4	381	c.226C>T	c.(226-228)CTG>TTG	p.L76L	MYEOV2_uc002vyu.1_5'Flank|MYEOV2_uc010zof.1_5'Flank	NM_148961	NP_683764	Q8NHW6	OTOSP_HUMAN	otospiralin precursor	76						extracellular region					0		all_epithelial(40;2.79e-15)|Breast(86;3.04e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0396)|Lung NSC(271;0.128)|Hepatocellular(293;0.148)|all_hematologic(139;0.158)|Melanoma(123;0.16)		Epithelial(32;2.56e-30)|all cancers(36;7.18e-28)|OV - Ovarian serous cystadenocarcinoma(60;2.37e-14)|Kidney(56;2.99e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;8.07e-06)|Lung(119;0.00344)|LUSC - Lung squamous cell carcinoma(224;0.0148)|Colorectal(34;0.019)|COAD - Colon adenocarcinoma(134;0.141)		GTGCTCCCCAGGGGGAAGTGG	0.652			NA											23	80					0	0	0.00333	0	0
NEU4	129807	broad.mit.edu	37	2	242757727	242757727	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr2:242757727C>A	uc010fzr.2	+	4	894	c.808C>A	c.(808-810)CCC>ACC	p.P270T	NEU4_uc002wcl.2_RNA|NEU4_uc002wcm.2_Missense_Mutation_p.P270T|NEU4_uc002wcn.1_Missense_Mutation_p.P282T|NEU4_uc002wco.1_Missense_Mutation_p.P270T|NEU4_uc002wcp.1_Missense_Mutation_p.P282T	NM_080741	NP_542779	Q8WWR8	NEUR4_HUMAN	sialidase 4	270						lysosomal lumen|organelle inner membrane	exo-alpha-sialidase activity|protein binding				0		all_cancers(19;1.09e-40)|all_epithelial(40;2.03e-18)|Breast(86;1.53e-05)|all_lung(227;0.00338)|Renal(207;0.00502)|Ovarian(221;0.00716)|Lung NSC(271;0.012)|Esophageal squamous(248;0.129)|Melanoma(123;0.144)|all_hematologic(139;0.158)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;3.84e-33)|all cancers(36;8.08e-31)|OV - Ovarian serous cystadenocarcinoma(60;7.41e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;1.63e-06)|Lung(119;0.000152)|LUSC - Lung squamous cell carcinoma(224;0.00154)|Colorectal(34;0.0129)|COAD - Colon adenocarcinoma(134;0.0825)		GGCTTCCCTGCCCGAGACTGC	0.706			NA											5	10					3.59834e-05	4.43119e-05	0.001168	1	0
C2orf85	285093	broad.mit.edu	37	2	242814448	242814448	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr2:242814448C>A	uc010fzu.1	+	2	764	c.741C>A	c.(739-741)TTC>TTA	p.F247L		NM_173821	NP_776182	Q14D33	CB085_HUMAN	hypothetical protein LOC285093	247						integral to membrane				ovary(1)	1						GCTCCATCTTCCTGTCTGGGG	0.692			NA											7	38					1.12685e-05	1.42141e-05	0.004482	1	0
SIRPA	140885	broad.mit.edu	37	20	1896081	1896081	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr20:1896081G>A	uc002wfq.2	+	3	776	c.416G>A	c.(415-417)GGC>GAC	p.G139D	SIRPA_uc010zps.1_Missense_Mutation_p.G119D|SIRPA_uc002wfr.2_Missense_Mutation_p.G139D|SIRPA_uc002wfs.2_Missense_Mutation_p.G139D|SIRPA_uc002wft.2_Missense_Mutation_p.G139D	NM_001040022	NP_001035111	P78324	SHPS1_HUMAN	signal-regulatory protein alpha precursor	139	Extracellular (Potential).				blood coagulation|cell adhesion|cell junction assembly|leukocyte migration	integral to membrane|plasma membrane	SH3 domain binding			ovary(1)	1				Colorectal(46;0.018)|READ - Rectum adenocarcinoma(1;0.0556)		TCTGGAGCAGGCACTGAGCTG	0.532	GBM(155;1668 1920 5945 42733 48121)		NA											23	134					0	0	0.00333	0	0
TGM6	343641	broad.mit.edu	37	20	2411621	2411621	+	Missense_Mutation	SNP	T	T	A			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr20:2411621T>A	uc002wfy.1	+	12	1976	c.1915T>A	c.(1915-1917)TGT>AGT	p.C639S	TGM6_uc010gal.1_Intron	NM_198994	NP_945345	O95932	TGM3L_HUMAN	transglutaminase 6	639					cell death|peptide cross-linking		acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			ovary(3)|skin(1)	4					L-Glutamine(DB00130)	AGTGAAGGACTGTGCGCTGAT	0.597			NA											76	165					0	0	0.00361	0	0
CPXM1	56265	broad.mit.edu	37	20	2779518	2779518	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr20:2779518C>A	uc002wgu.2	-	2	258	c.194G>T	c.(193-195)CGG>CTG	p.R65L	CPXM1_uc010gas.2_Missense_Mutation_p.R65L	NM_019609	NP_062555	Q96SM3	CPXM1_HUMAN	carboxypeptidase X, member 1 precursor	65					cell adhesion|proteolysis		metallocarboxypeptidase activity|zinc ion binding			ovary(2)|skin(2)	4						GACTCGAATCCGGACATGCTG	0.552			NA											76	173					1.50424e-25	2.89009e-25	0.00361	1	0
MACROD2	140733	broad.mit.edu	37	20	16025241	16025241	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr20:16025241G>T	uc002wou.2	+	17	1521	c.1257G>T	c.(1255-1257)AAG>AAT	p.K419N	MACROD2_uc002wot.2_Intron|MACROD2_uc002woz.2_Missense_Mutation_p.K184N|MACROD2_uc002wpb.2_Intron|MACROD2_uc002wpd.2_Missense_Mutation_p.K70N	NM_080676	NP_542407	A1Z1Q3	MACD2_HUMAN	MACRO domain containing 2 isoform 1	419											0		all_neural(2;0.0381)|Acute lymphoblastic leukemia(2;0.175)				AGGTTGACAAGGTAAATGACC	0.343			NA											13	35					5.01169e-05	6.13526e-05	0.00499	1	0
KIF16B	55614	broad.mit.edu	37	20	16360585	16360585	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr20:16360585G>T	uc002wpg.1	-	19	2220	c.2062C>A	c.(2062-2064)CAG>AAG	p.Q688K	KIF16B_uc002wpe.1_Missense_Mutation_p.Q70K|KIF16B_uc002wpf.1_Missense_Mutation_p.Q70K|KIF16B_uc010gch.1_Missense_Mutation_p.Q688K|KIF16B_uc010gci.1_Missense_Mutation_p.Q688K|KIF16B_uc010gcj.1_Missense_Mutation_p.Q699K	NM_024704	NP_078980	Q96L93	KI16B_HUMAN	kinesin-like motor protein C20orf23	688	Glu-rich.|Potential.				cell communication|early endosome to late endosome transport|endoderm development|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|formation of primary germ layer|Golgi to endosome transport|microtubule-based movement|receptor catabolic process|regulation of receptor recycling	early endosome membrane|microtubule	ATP binding|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding|plus-end-directed microtubule motor activity			skin(2)|large_intestine(1)|central_nervous_system(1)|lung(1)|breast(1)|ovary(1)|kidney(1)	8						TCGATTTCCTGCTGTTCCCTC	0.488			NA											27	301					8.24728e-16	1.45026e-15	0.004656	1	0
SSTR4	6754	broad.mit.edu	37	20	23016906	23016906	+	Silent	SNP	G	G	T	rs72547257		TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr20:23016906G>T	uc002wsr.2	+	1	850	c.786G>T	c.(784-786)CTG>CTT	p.L262L		NM_001052	NP_001043	P31391	SSR4_HUMAN	somatostatin receptor 4	262	Helical; Name=6; (Potential).				G-protein signaling, coupled to cyclic nucleotide second messenger|negative regulation of cell proliferation	integral to plasma membrane	somatostatin receptor activity			ovary(1)	1	Colorectal(13;0.0518)|Lung NSC(19;0.0542)|all_lung(19;0.118)					GGCTGGTGCTGATGGTCGTGG	0.612	Esophageal Squamous(15;850 1104 16640)		NA											44	97					1.56793e-16	2.79266e-16	0.00361	1	0
CDK5RAP1	51654	broad.mit.edu	37	20	31973519	31973519	+	Silent	SNP	C	C	A			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr20:31973519C>A	uc010gek.2	-	7	937	c.813G>T	c.(811-813)CGG>CGT	p.R271R	CDK5RAP1_uc002wyy.2_Silent_p.R181R|CDK5RAP1_uc002wyz.2_Silent_p.R271R|CDK5RAP1_uc002wza.2_Silent_p.R271R|CDK5RAP1_uc010gel.2_Silent_p.R180R|CDK5RAP1_uc010gem.2_Silent_p.R271R|CDK5RAP1_uc002wzc.1_Silent_p.R271R|CDK5RAP1_uc010gen.2_Silent_p.R271R	NM_016408	NP_057492	Q96SZ6	CK5P1_HUMAN	CDK5 regulatory subunit associated protein 1	271					brain development|negative regulation of cyclin-dependent protein kinase activity|regulation of neuron differentiation|tRNA modification	cytoplasm	4 iron, 4 sulfur cluster binding|metal ion binding|neuronal Cdc2-like kinase binding|transferase activity			ovary(2)|skin(2)|lung(1)	5						TCTCCCTGCCCCGGGTGAAAG	0.493			NA											15	119					3.62473e-10	5.53038e-10	0.001882	1	0
TSHZ2	128553	broad.mit.edu	37	20	51872011	51872011	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr20:51872011C>A	uc002xwo.2	+	2	2970	c.2014C>A	c.(2014-2016)CCC>ACC	p.P672T		NM_173485	NP_775756	Q9NRE2	TSH2_HUMAN	teashirt zinc finger homeobox 2	672					multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(5)|haematopoietic_and_lymphoid_tissue(1)	6			STAD - Stomach adenocarcinoma(23;0.1)			GCCCCTGGAGCCCACATCTGC	0.612			NA											4	92					0.00024832	0.000288663	0.009096	1	0
ZNF831	128611	broad.mit.edu	37	20	57766620	57766620	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr20:57766620G>T	uc002yan.2	+	1	546	c.546G>T	c.(544-546)AAG>AAT	p.K182N		NM_178457	NP_848552	Q5JPB2	ZN831_HUMAN	zinc finger protein 831	182	C2H2-type 2.					intracellular	nucleic acid binding|zinc ion binding			skin(13)|ovary(1)	14	all_lung(29;0.0085)					TCGCCTTTAAGACCCAGAGCA	0.647			NA											97	166					9.53958e-58	1.90333e-57	0.00361	1	0
ZBTB46	140685	broad.mit.edu	37	20	62421767	62421767	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr20:62421767G>T	uc002ygv.1	-	2	545	c.344C>A	c.(343-345)ACG>AAG	p.T115K	ZBTB46_uc002ygu.2_RNA	NM_025224	NP_079500	Q86UZ6	ZBT46_HUMAN	zinc finger and BTB domain containing 46	115					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			large_intestine(1)|ovary(1)	2	all_cancers(38;2.09e-12)|all_epithelial(29;3.8e-14)|Lung NSC(23;7.61e-10)|all_lung(23;2.64e-09)					CACGATGTCCGTCATCTGCAG	0.597			NA											3	21					6.4e-05	7.74515e-05	0.004672	1	0
ZNF295	49854	broad.mit.edu	37	21	43414063	43414063	+	Missense_Mutation	SNP	A	A	C			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr21:43414063A>C	uc002zab.3	-	3	356	c.142T>G	c.(142-144)TTG>GTG	p.L48V	ZNF295_uc002yzz.3_Missense_Mutation_p.L48V|ZNF295_uc002yzy.3_Missense_Mutation_p.L48V|ZNF295_uc002zaa.3_Missense_Mutation_p.L48V|ZNF295_uc010gov.1_Missense_Mutation_p.L48V|ZNF295_uc002zac.2_Missense_Mutation_p.L48V	NM_001098402	NP_001091872	Q9ULJ3	ZN295_HUMAN	zinc finger protein 295 isoform L	48	Mediates homodimerization.|BTB.				negative regulation of transcription, DNA-dependent|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|nucleus	methyl-CpG binding|protein binding|zinc ion binding			ovary(1)|central_nervous_system(1)|skin(1)	3						CTGGCAGCCAAGACGTTTTTA	0.438			NA											13	97					0	0	0.00245	0	0
CECR2	27443	broad.mit.edu	37	22	18020342	18020342	+	Silent	SNP	C	C	T			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr22:18020342C>T	uc010gqw.1	+	13	1797	c.1671C>T	c.(1669-1671)CCC>CCT	p.P557P	CECR2_uc010gqv.1_Silent_p.P416P|CECR2_uc002zml.2_Silent_p.P416P	NM_031413	NP_113601	Q9BXF3	CECR2_HUMAN	cat eye syndrome chromosome region, candidate 2	599					chromatin modification|cytokinesis|cytoskeleton organization|DNA fragmentation involved in apoptotic nuclear change|vesicle-mediated transport		protein binding			ovary(1)|skin(1)	2		all_epithelial(15;0.139)		Lung(27;0.146)		CGTTGCCCCCCACACGCCGAG	0.637			NA											5	57					0	0	0.004482	0	0
HIRA	7290	broad.mit.edu	37	22	19365417	19365417	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr22:19365417C>G	uc002zpf.1	-	14	1808	c.1588G>C	c.(1588-1590)GCA>CCA	p.A530P	HIRA_uc011agx.1_Missense_Mutation_p.A396P|HIRA_uc010grn.1_Missense_Mutation_p.A530P|HIRA_uc010gro.1_Missense_Mutation_p.A486P|HIRA_uc010grp.2_RNA	NM_003325	NP_003316	P54198	HIRA_HUMAN	HIR histone cell cycle regulation defective	530	Interaction with CCNA1.				chromatin modification|regulation of transcription from RNA polymerase II promoter	PML body	chromatin binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			ovary(1)	1	Colorectal(54;0.0993)					GAATCGCCTGCAGGTCTGGCA	0.542			NA											7	136					0	0	0.001368	0	0
MYO18B	84700	broad.mit.edu	37	22	26165096	26165096	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr22:26165096G>C	uc003abz.1	+	4	1463	c.1213G>C	c.(1213-1215)GCA>CCA	p.A405P	MYO18B_uc003aca.1_Missense_Mutation_p.A286P|MYO18B_uc010guy.1_Missense_Mutation_p.A286P|MYO18B_uc010guz.1_Missense_Mutation_p.A286P|MYO18B_uc011aka.1_5'UTR|MYO18B_uc011akb.1_5'Flank	NM_032608	NP_115997	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	405						nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity			ovary(5)|central_nervous_system(3)|large_intestine(2)|breast(2)	12						GTCCGGGAACGCAGGTGAAGC	0.607			NA											3	37					0	0	0.004672	0	0
HPS4	89781	broad.mit.edu	37	22	26868863	26868863	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr22:26868863G>A	uc003acl.2	-	5	978	c.319C>T	c.(319-321)CGG>TGG	p.R107W	HPS4_uc003aci.2_Missense_Mutation_p.R102W|HPS4_uc003acj.2_5'UTR|HPS4_uc003ack.2_5'UTR|HPS4_uc003acn.2_5'UTR|HPS4_uc010gvd.1_Missense_Mutation_p.R107W|HPS4_uc003ach.2_5'Flank	NM_022081	NP_071364	Q9NQG7	HPS4_HUMAN	light ear protein isoform a	107					lysosome organization|positive regulation of eye pigmentation|protein stabilization|protein targeting	lysosome|melanosome|membrane fraction|platelet dense granule	protein homodimerization activity				0						TCCAGAAACCGCTTGCAGCTG	0.418			NA							Hermansky-Pudlak_syndrome				10	155					0	0	0.006214	0	0
MYH9	4627	broad.mit.edu	37	22	36708162	36708162	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr22:36708162G>T	uc003apg.2	-	14	1891	c.1660C>A	c.(1660-1662)CCC>ACC	p.P554T	MYH9_uc003aph.1_Missense_Mutation_p.P418T	NM_002473	NP_002464	P35579	MYH9_HUMAN	myosin, heavy polypeptide 9, non-muscle	554	Myosin head-like.				actin cytoskeleton reorganization|actin filament-based movement|angiogenesis|axon guidance|blood vessel endothelial cell migration|cytokinesis|integrin-mediated signaling pathway|leukocyte migration|membrane protein ectodomain proteolysis|monocyte differentiation|platelet formation|protein transport|regulation of cell shape	actomyosin contractile ring|cleavage furrow|cytosol|myosin complex|nucleus|ruffle|stress fiber|uropod	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity|protein anchor|protein homodimerization activity			breast(3)|ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|lung(1)|skin(1)|kidney(1)|pancreas(1)	11						TGGAACTTGGGGTGGGTGCCC	0.612			NA	T	ALK	ALCL		Deafness|autosomal dominant 17|Epstein syndrome|Fechtner syndrome|May-Hegglin anomaly|Sebastian syndrome		Hereditary_Macrothrombocytopenia_MYH9-associated				10	128					0.000442599	0.000501854	0.006214	1	0
TTLL1	25809	broad.mit.edu	37	22	43460246	43460246	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr22:43460246G>T	uc003bdi.2	-	6	829	c.588C>A	c.(586-588)GAC>GAA	p.D196E	TTLL1_uc010gzh.2_Missense_Mutation_p.D196E|TTLL1_uc003bdj.2_Missense_Mutation_p.D82E|TTLL1_uc003bdh.2_Missense_Mutation_p.D158E	NM_012263	NP_036395	O95922	TTLL1_HUMAN	tubulin tyrosine ligase-like family, member 1	196	TTL.				protein polyglutamylation	cytoplasm|microtubule	ATP binding|tubulin-glutamic acid ligase activity|tubulin-tyrosine ligase activity			skin(1)	1		Ovarian(80;0.0694)		BRCA - Breast invasive adenocarcinoma(115;0.00461)		ACAAGCGCAGGTCGAACTTCC	0.463			NA											7	84					0.000274275	0.000316178	0.004482	1	0
IL5RA	3568	broad.mit.edu	37	3	3136995	3136995	+	Silent	SNP	A	A	G			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr3:3136995A>G	uc011ask.1	-	9	1487	c.843T>C	c.(841-843)AAT>AAC	p.N281N	IL5RA_uc010hbq.2_Intron|IL5RA_uc010hbr.2_Intron|IL5RA_uc010hbs.2_Silent_p.N281N|IL5RA_uc011asl.1_Silent_p.N281N|IL5RA_uc011asm.1_Silent_p.N281N|IL5RA_uc010hbt.2_Silent_p.N281N|IL5RA_uc011asn.1_Silent_p.N281N|IL5RA_uc010hbu.2_Silent_p.N281N|IL5RA_uc010hbp.2_5'Flank	NM_000564	NP_000555	Q01344	IL5RA_HUMAN	interleukin 5 receptor, alpha isoform 1	281	Extracellular (Potential).				cell proliferation	extracellular space|integral to membrane|plasma membrane	interleukin-5 receptor activity			ovary(1)	1				Epithelial(13;0.00278)|all cancers(10;0.00809)|OV - Ovarian serous cystadenocarcinoma(96;0.00944)		GCAAATATCCATTCCTTGTAT	0.323	GBM(169;430 2801 24955 28528)		NA											8	41					0	0	0.001855	0	0
LMCD1	29995	broad.mit.edu	37	3	8590464	8590464	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr3:8590464G>A	uc003bqq.2	+	4	712	c.598G>A	c.(598-600)GCC>ACC	p.A200T	LMCD1_uc011atd.1_Missense_Mutation_p.A127T|LMCD1_uc011ate.1_Missense_Mutation_p.A88T|LMCD1_uc011atf.1_Missense_Mutation_p.A127T	NM_014583	NP_055398	Q9NZU5	LMCD1_HUMAN	LIM and cysteine-rich domains 1	200	PET.				positive regulation of calcineurin-NFAT signaling pathway|regulation of cardiac muscle hypertrophy|transcription, DNA-dependent	cytoplasm|extracellular space|nucleus	transcription corepressor activity|zinc ion binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(96;0.124)		GGGAGAAGTGGCCCTCCCGGG	0.592			NA											23	127					0	0	0.004656	0	0
OGG1	4968	broad.mit.edu	37	3	9792684	9792684	+	Missense_Mutation	SNP	A	A	G			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr3:9792684A>G	uc003bsi.2	+	2	536	c.193A>G	c.(193-195)ACA>GCA	p.T65A	OGG1_uc003bsh.2_Missense_Mutation_p.T65A|OGG1_uc003bsj.2_Missense_Mutation_p.T65A|OGG1_uc003bsk.2_Missense_Mutation_p.T65A|OGG1_uc003bsl.2_Missense_Mutation_p.T65A|OGG1_uc003bsm.2_Missense_Mutation_p.T65A|OGG1_uc003bsn.2_Missense_Mutation_p.T65A|OGG1_uc003bso.2_Missense_Mutation_p.T65A|OGG1_uc003bsp.1_5'Flank|OGG1_uc010hcm.1_5'Flank|OGG1_uc003bsq.1_5'Flank|OGG1_uc003bsr.1_5'Flank	NM_002542	NP_002533	O15527	OGG1_HUMAN	8-oxoguanine DNA-glycosylase 1 isoform 1a	65					depurination|nucleotide-excision repair|regulation of protein import into nucleus, translocation|regulation of transcription, DNA-dependent|response to oxidative stress|response to radiation	mitochondrion|nuclear matrix|nuclear speck	damaged DNA binding|endonuclease activity|oxidized purine base lesion DNA N-glycosylase activity|protein binding				0	Medulloblastoma(99;0.227)					TCAAGTATGGACACTGACTCA	0.572			NA						BER_DNA_glycosylases					4	38					0	0	0.000602	0	0
ATP2B2	491	broad.mit.edu	37	3	10381973	10381973	+	Missense_Mutation	SNP	A	A	T			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr3:10381973A>T	uc003bvt.2	-	21	3629	c.3190T>A	c.(3190-3192)TGG>AGG	p.W1064R	ATP2B2_uc003bvv.2_Missense_Mutation_p.W1019R|ATP2B2_uc003bvw.2_Missense_Mutation_p.W1019R|ATP2B2_uc010hdo.2_Missense_Mutation_p.W769R	NM_001001331	NP_001001331	Q01814	AT2B2_HUMAN	plasma membrane calcium ATPase 2 isoform 1	1064	Helical; (Potential).				ATP biosynthetic process|cytosolic calcium ion homeostasis|platelet activation	cytosol|integral to membrane|plasma membrane	ATP binding|ATP binding|calcium ion binding|calcium-transporting ATPase activity|calcium-transporting ATPase activity|calmodulin binding|calmodulin binding|metal ion binding|PDZ domain binding|protein C-terminus binding			ovary(3)|skin(2)|central_nervous_system(1)	6						CACCACATCCACTGGTCCAGC	0.557	Ovarian(125;1619 1709 15675 19819 38835)		NA											19	78					0	0	0.002299	0	0
SGOL1	151648	broad.mit.edu	37	3	20216127	20216127	+	Missense_Mutation	SNP	T	T	C			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr3:20216127T>C	uc003cbs.2	-	6	1083	c.896A>G	c.(895-897)AAC>AGC	p.N299S	SGOL1_uc003cbr.2_Intron|SGOL1_uc010hfa.2_Intron|SGOL1_uc003cbt.2_Intron|SGOL1_uc003cbu.2_Missense_Mutation_p.N299S|SGOL1_uc003cbv.2_Intron|SGOL1_uc003cbw.2_Intron|SGOL1_uc003cbx.2_Intron|SGOL1_uc003cby.2_Intron|SGOL1_uc003cbz.2_Missense_Mutation_p.N299S|SGOL1_uc003cca.2_Missense_Mutation_p.N299S|SGOL1_uc003ccb.2_Intron|SGOL1_uc003ccc.2_Intron	NM_001012410	NP_001012410	Q5FBB7	SGOL1_HUMAN	shugoshin-like 1 isoform A2	299	Potential.				attachment of spindle microtubules to kinetochore|cell division|centriole-centriole cohesion|meiotic chromosome segregation|mitotic prometaphase	centrosome|condensed chromosome kinetochore|cytosol|mitotic cohesin complex|spindle pole	protein binding				0						ttttctcctgttagcttttct	0.129			NA											6	55					0	0	0.001984	0	0
DCLK3	85443	broad.mit.edu	37	3	36779774	36779774	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr3:36779774C>T	uc003cgi.2	-	2	868	c.377G>A	c.(376-378)GGG>GAG	p.G126E		NM_033403	NP_208382	Q9C098	DCLK3_HUMAN	doublecortin-like kinase 3	126						cytoplasm|nucleus	ATP binding|protein serine/threonine kinase activity			lung(3)|large_intestine(2)|breast(1)|skin(1)|ovary(1)|kidney(1)	9						AATCTCCACCCCAAGATGCTT	0.567			NA											32	266					0	0	0.002836	0	0
TDGF1	6997	broad.mit.edu	37	3	46621261	46621261	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr3:46621261G>T	uc003cpv.2	+	4	536	c.256G>T	c.(256-258)GGG>TGG	p.G86W	LRRC2_uc003cpu.3_Intron	NM_003212	NP_003203	P13385	TDGF1_HUMAN	teratocarcinoma-derived growth factor 1	86	EGF-like.				activation of MAPK activity|anterior/posterior axis specification, embryo|mammary gland development|morphogenesis of a branching structure|negative regulation of apoptosis|peptidyl-serine phosphorylation|positive regulation of cell migration|positive regulation of peptidyl-tyrosine phosphorylation	anchored to membrane|cell surface|extrinsic to plasma membrane	growth factor activity				0				BRCA - Breast invasive adenocarcinoma(193;0.00114)|KIRC - Kidney renal clear cell carcinoma(197;0.0173)|Kidney(197;0.0204)		CTGCCTGAATGGGGGAACCTG	0.527			NA											27	203					5.77227e-19	1.05528e-18	0.008361	1	0
WDR6	11180	broad.mit.edu	37	3	49052329	49052329	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr3:49052329C>T	uc003cvj.2	+	6	3202	c.3064C>T	c.(3064-3066)CGT>TGT	p.R1022C	WDR6_uc011bby.1_Missense_Mutation_p.R470C|WDR6_uc010hkn.2_Missense_Mutation_p.R966C|WDR6_uc011bbz.1_Missense_Mutation_p.R941C	NM_018031	NP_060501	Q9NNW5	WDR6_HUMAN	WD repeat domain 6 protein	992	WD 15.				cell cycle arrest|negative regulation of cell proliferation	cytoplasm				central_nervous_system(1)	1				Kidney(197;9.12e-07)|KIRC - Kidney renal clear cell carcinoma(197;1.32e-05)|BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|OV - Ovarian serous cystadenocarcinoma(275;0.000155)		CTTGCCCACCCGTGAGGGCCA	0.587			NA											10	67					0	0	0.001368	0	0
LRTM1	57408	broad.mit.edu	37	3	54961995	54961995	+	Translation_Start_Site	SNP	G	G	T			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr3:54961995G>T	uc003dhl.2	-	1	78	c.-56C>A	c.(-58--54)CTCTG>CTATG		CACNA2D3_uc003dhf.2_Intron|CACNA2D3_uc003dhg.1_Intron|CACNA2D3_uc003dhh.1_Intron	NM_020678	NP_065729	Q9HBL6	LRTM1_HUMAN	leucine-rich repeats and transmembrane domains 1							integral to membrane					0				KIRC - Kidney renal clear cell carcinoma(284;0.00975)|Kidney(284;0.0112)|OV - Ovarian serous cystadenocarcinoma(275;0.0502)		TTAATGTGCAGAGCAACACAC	0.478			NA											7	144					4.84862e-15	8.41914e-15	0.000978	1	0
CADPS	8618	broad.mit.edu	37	3	62478119	62478119	+	Silent	SNP	G	G	T			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr3:62478119G>T	uc003dll.2	-	20	3090	c.2730C>A	c.(2728-2730)GCC>GCA	p.A910A	CADPS_uc003dlk.1_Silent_p.A407A|CADPS_uc003dlm.2_Silent_p.A920A|CADPS_uc003dln.2_Silent_p.A880A	NM_003716	NP_003707	Q9ULU8	CAPS1_HUMAN	Ca2+-dependent secretion activator isoform 1	910	Interaction with DRD2.				exocytosis|protein transport	cell junction|cytoplasmic vesicle membrane|cytosol|synapse	lipid binding|metal ion binding			central_nervous_system(2)|ovary(1)	3		Lung SC(41;0.0452)		BRCA - Breast invasive adenocarcinoma(55;5.98e-05)|KIRC - Kidney renal clear cell carcinoma(15;0.0246)|Kidney(15;0.0334)		ACCACGCAAAGGCCTTTAAAA	0.448			NA											21	504					1.10513e-12	1.81996e-12	0.002299	1	0
SLC25A26	115286	broad.mit.edu	37	3	66413339	66413339	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr3:66413339G>A	uc011bfq.1	+	8	1282	c.554G>A	c.(553-555)TGT>TAT	p.C185Y	SLC25A26_uc011bfs.1_Missense_Mutation_p.C97Y|SLC25A26_uc011bft.1_RNA|SLC25A26_uc011bfr.1_Missense_Mutation_p.C185Y|SLC25A26_uc003dmt.2_Missense_Mutation_p.C97Y	NM_173471	NP_775742	Q70HW3	SAMC_HUMAN	solute carrier family 25, member 26 isoform a	185	Helical; Name=5; (Potential).|Solcar 3.					integral to membrane|mitochondrial inner membrane|nucleus	S-adenosylmethionine transmembrane transporter activity			pancreas(1)	1		Lung NSC(201;0.00774)		BRCA - Breast invasive adenocarcinoma(55;0.00046)|KIRC - Kidney renal clear cell carcinoma(15;0.0515)|Kidney(15;0.0648)		TCAGCAGTCTGTGGAGCTTTT	0.383			NA											5	17					0	0	0.000602	0	0
CNTN3	5067	broad.mit.edu	37	3	74315728	74315728	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr3:74315728G>T	uc003dpm.1	-	21	2970	c.2890C>A	c.(2890-2892)CTG>ATG	p.L964M		NM_020872	NP_065923	Q9P232	CNTN3_HUMAN	contactin 3 precursor	964	Fibronectin type-III 4.				cell adhesion	anchored to membrane|plasma membrane	protein binding			breast(3)|ovary(1)|skin(1)	5		Lung NSC(201;0.138)|Lung SC(41;0.21)		Epithelial(33;0.00212)|BRCA - Breast invasive adenocarcinoma(55;0.00258)|LUSC - Lung squamous cell carcinoma(21;0.00461)|Lung(16;0.01)		TTAATGGGCAGCACAAGTTCA	0.393			NA											20	189					1.28384e-07	1.72425e-07	0.001882	1	0
PROS1	5627	broad.mit.edu	37	3	93605343	93605343	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr3:93605343G>A	uc003drb.3	-	11	1501	c.1160C>T	c.(1159-1161)TCT>TTT	p.S387F	PROS1_uc010hoo.2_Missense_Mutation_p.S256F|PROS1_uc003dqz.3_Missense_Mutation_p.S256F	NM_000313	NP_000304	P07225	PROS_HUMAN	protein S, alpha preproprotein	387	Laminin G-like 1.				leukocyte migration|peptidyl-glutamic acid carboxylation|platelet activation|platelet degranulation|post-translational protein modification|proteolysis	endoplasmic reticulum membrane|extracellular region|Golgi lumen|Golgi membrane|platelet alpha granule lumen	calcium ion binding|endopeptidase inhibitor activity			large_intestine(1)	1					Antihemophilic Factor(DB00025)|Drotrecogin alfa(DB00055)|Menadione(DB00170)	TTCTTCCACAGACACCTACAA	0.294			NA											30	147					0	0	0.009535	0	0
CCDC80	151887	broad.mit.edu	37	3	112357838	112357838	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr3:112357838G>T	uc003dzf.2	-	2	1133	c.915C>A	c.(913-915)AGC>AGA	p.S305R	CCDC80_uc011bhv.1_Missense_Mutation_p.S305R|CCDC80_uc003dzg.2_Missense_Mutation_p.S305R|CCDC80_uc003dzh.1_Missense_Mutation_p.S305R	NM_199512	NP_955806	Q76M96	CCD80_HUMAN	steroid-sensitive protein 1 precursor	305										ovary(2)	2						CGCTGCCCAGGCTTGGCCTTC	0.597			NA											27	105					7.07758e-08	9.72581e-08	0.004656	1	0
DRD3	1814	broad.mit.edu	37	3	113890615	113890615	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr3:113890615G>T	uc003ebd.2	-	3	648	c.225C>A	c.(223-225)GAC>GAA	p.D75E	DRD3_uc010hqn.1_Missense_Mutation_p.D75E|DRD3_uc003ebb.1_Missense_Mutation_p.D75E|DRD3_uc003ebc.1_Missense_Mutation_p.D75E	NM_000796	NP_000787	P35462	DRD3_HUMAN	dopamine receptor D3 isoform a	75	Helical; Name=2.				activation of adenylate cyclase activity by dopamine receptor signaling pathway|arachidonic acid secretion|behavioral response to cocaine|cellular calcium ion homeostasis|circadian regulation of gene expression|G-protein coupled receptor internalization|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|locomotory behavior|musculoskeletal movement, spinal reflex action|negative regulation of blood pressure|negative regulation of oligodendrocyte differentiation|negative regulation of protein kinase B signaling cascade|negative regulation of protein secretion|positive regulation of dopamine receptor signaling pathway|positive regulation of mitosis|prepulse inhibition|regulation of dopamine secretion|response to drug|response to histamine|response to morphine|social behavior|visual learning	integral to plasma membrane	dopamine D3 receptor activity|drug binding			ovary(1)|pancreas(1)|central_nervous_system(1)|skin(1)	4					Apomorphine(DB00714)|Chlorprothixene(DB01239)|Cocaine(DB00907)|Methotrimeprazine(DB01403)|Olanzapine(DB00334)|Pramipexole(DB00413)|Ropinirole(DB00268)|Ziprasidone(DB00246)	CCACCAGCAAGTCTGCCACAG	0.557			NA											11	105					2.61681e-11	4.17684e-11	0.00245	1	0
ZNF80	7634	broad.mit.edu	37	3	113955452	113955452	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr3:113955452C>T	uc010hqo.2	-	1	974	c.470G>A	c.(469-471)GGA>GAA	p.G157E	ZNF80_uc003ebf.2_RNA	NM_007136	NP_009067	P51504	ZNF80_HUMAN	zinc finger protein 80	157						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Lung NSC(201;0.0233)|all_neural(597;0.0837)				GAGTTTTTCTCCAGTGTGGGT	0.483	GBM(23;986 1114 21716)		NA											11	119					0	0	0.001368	0	0
ARHGAP31	57514	broad.mit.edu	37	3	119133448	119133448	+	Missense_Mutation	SNP	A	A	T			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr3:119133448A>T	uc003ecj.3	+	12	3204	c.2672A>T	c.(2671-2673)GAT>GTT	p.D891V		NM_020754	NP_065805	Q2M1Z3	RHG31_HUMAN	Cdc42 GTPase-activating protein	891					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|focal adhesion|lamellipodium	GTPase activator activity			ovary(2)	2						TGTGACGAAGATGACACTGTG	0.557	Pancreas(7;176 297 5394 51128 51241)		NA											26	124					0	0	0.004656	0	0
MED12L	116931	broad.mit.edu	37	3	150881712	150881712	+	Silent	SNP	G	G	T			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr3:150881712G>T	uc003eyp.2	+	8	1178	c.1140G>T	c.(1138-1140)GTG>GTT	p.V380V	MED12L_uc011bnz.1_Intron|MED12L_uc003eyn.2_Silent_p.V380V|MED12L_uc003eyo.2_Silent_p.V380V	NM_053002	NP_443728	Q86YW9	MD12L_HUMAN	mediator of RNA polymerase II transcription,	380					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	mediator complex				ovary(4)|large_intestine(1)|central_nervous_system(1)|skin(1)	7			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			GTGCCTTGGTGTGGAATTATT	0.493			NA											9	107					0.000442599	0.000501854	0.006214	1	0
PLCH1	23007	broad.mit.edu	37	3	155200774	155200774	+	Missense_Mutation	SNP	T	T	A			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr3:155200774T>A	uc011bok.1	-	23	3342	c.3065A>T	c.(3064-3066)AAC>ATC	p.N1022I	PLCH1_uc011boj.1_3'UTR|PLCH1_uc011bol.1_Missense_Mutation_p.N984I	NM_001130960	NP_001124432	Q4KWH8	PLCH1_HUMAN	phospholipase C eta 1 isoform a	1022					lipid catabolic process|phosphatidylinositol-mediated signaling	membrane	calcium ion binding|calcium-dependent phospholipase C activity|phosphatidylinositol phospholipase C activity|signal transducer activity			skin(3)|ovary(1)	4			Lung(72;0.11)|LUSC - Lung squamous cell carcinoma(72;0.114)			TAACTTTTTGTTGAAATTTAG	0.408			NA											9	119					0	0	0.004482	0	0
ATP13A4	84239	broad.mit.edu	37	3	193132540	193132540	+	Splice_Site	SNP	C	C	A			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr3:193132540C>A	uc003ftd.2	-	26	2951	c.2843_splice	c.e26-1	p.M948_splice	ATP13A4_uc010hzi.2_Splice_Site	NM_032279	NP_115655	Q4VNC1	AT134_HUMAN	ATPase type 13A4						ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			ovary(2)	2	all_cancers(143;1.76e-08)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(49;2.72e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;0.000109)		TTCAGATTCACTATAAAATAA	0.303			NA											9	76					9.70103e-10	1.46397e-09	0.008291	1	0
CPN2	1370	broad.mit.edu	37	3	194062704	194062704	+	Missense_Mutation	SNP	A	A	T			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr3:194062704A>T	uc003fts.2	-	2	818	c.728T>A	c.(727-729)CTA>CAA	p.L243Q		NM_001080513	NP_001073982	P22792	CPN2_HUMAN	carboxypeptidase N, polypeptide 2	243	LRR 7.				protein stabilization	extracellular region	enzyme regulator activity			ovary(5)	5	all_cancers(143;5.31e-09)|Ovarian(172;0.0634)		OV - Ovarian serous cystadenocarcinoma(49;2.2e-17)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;4.65e-05)		CAGCCTCTCTAGGCAGAAGAG	0.582			NA											5	42					0	0	0.001368	0	0
USP46	64854	broad.mit.edu	37	4	53468216	53468216	+	Missense_Mutation	SNP	T	T	A			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr4:53468216T>A	uc003gzn.2	-	7	912	c.727A>T	c.(727-729)AGG>TGG	p.R243W	USP46_uc003gzm.3_Missense_Mutation_p.R236W|USP46_uc011bzr.1_Missense_Mutation_p.R220W|USP46_uc011bzs.1_Missense_Mutation_p.R127W	NM_022832	NP_073743	P62068	UBP46_HUMAN	ubiquitin specific peptidase 46 isoform 1	243					behavior|protein deubiquitination|regulation of synaptic transmission, GABAergic|ubiquitin-dependent protein catabolic process		protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(1)	1			LUSC - Lung squamous cell carcinoma(32;0.0295)			TTTTTTACCCTCATCCTAAGA	0.448			NA											10	82					0	0	0.006214	0	0
KDR	3791	broad.mit.edu	37	4	55968660	55968660	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr4:55968660G>A	uc003has.2	-	14	2305	c.2003C>T	c.(2002-2004)ACG>ATG	p.T668M	KDR_uc003hat.1_Missense_Mutation_p.T668M	NM_002253	NP_002244	P35968	VGFR2_HUMAN	kinase insert domain receptor precursor	668	Ig-like C2-type 7.|Extracellular (Potential).				angiogenesis|cell differentiation|interspecies interaction between organisms|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of focal adhesion assembly|positive regulation of positive chemotaxis|regulation of cell shape	integral to plasma membrane	ATP binding|growth factor binding|Hsp90 protein binding|integrin binding|receptor signaling protein tyrosine kinase activity|vascular endothelial growth factor receptor activity			lung(16)|soft_tissue(4)|central_nervous_system(4)|large_intestine(2)|stomach(2)|skin(2)|ovary(2)|kidney(1)	33	all_cancers(7;0.0255)|all_lung(4;0.00175)|Lung NSC(11;0.00384)|all_epithelial(27;0.034)|Glioma(25;0.08)|all_neural(26;0.101)		Epithelial(7;0.189)		Sorafenib(DB00398)|Sunitinib(DB01268)	TCCTGTGATCGTGGGTGCCAC	0.428			NA	Mis		NSCLC|angiosarcoma				Familial_Infantile_Hemangioma	TSP Lung(20;0.16)			7	91					0	0	0.004482	0	0
UGT2B4	7363	broad.mit.edu	37	4	70361472	70361472	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr4:70361472C>A	uc003hek.3	-	1	155	c.108G>T	c.(106-108)TGG>TGT	p.W36C	UGT2B4_uc011cap.1_Intron|UGT2B4_uc003hel.3_Missense_Mutation_p.W36C	NM_021139	NP_066962	P06133	UD2B4_HUMAN	UDP glucuronosyltransferase 2B4 precursor	36					estrogen catabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			skin(2)	2						TTATATTCATCCAGTGGCTGA	0.468			NA											13	189					0.000151284	0.00017938	0.001855	1	0
LIN54	132660	broad.mit.edu	37	4	83905676	83905676	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr4:83905676C>A	uc003hnx.3	-	2	700	c.322G>T	c.(322-324)GTG>TTG	p.V108L	LIN54_uc003hnz.3_Intron|LIN54_uc003hny.3_Intron|LIN54_uc010ijt.2_Missense_Mutation_p.V108L|LIN54_uc010iju.2_5'UTR|LIN54_uc010ijv.2_Intron	NM_194282	NP_919258	Q6MZP7	LIN54_HUMAN	lin-54 homolog isoform a	108					cell cycle|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding				0		Hepatocellular(203;0.114)				GATATAGTCACAGGAGTCTGA	0.383			NA											14	182					3.27435e-08	4.57527e-08	0.00245	1	0
DSPP	1834	broad.mit.edu	37	4	88535090	88535090	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr4:88535090C>A	uc003hqu.2	+	5	1396	c.1276C>A	c.(1276-1278)CCT>ACT	p.P426T		NM_014208	NP_055023	Q9NZW4	DSPP_HUMAN	dentin sialophosphoprotein preproprotein	426					biomineral tissue development|ossification|skeletal system development	proteinaceous extracellular matrix	calcium ion binding|collagen binding|extracellular matrix structural constituent			central_nervous_system(1)	1		Hepatocellular(203;0.114)|all_hematologic(202;0.236)		OV - Ovarian serous cystadenocarcinoma(123;0.000508)		CATAGAAGGACCTGGCCAAAA	0.413			NA											21	72					8.10497e-08	1.11009e-07	0.010504	1	0
HERC6	55008	broad.mit.edu	37	4	89363544	89363544	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr4:89363544G>A	uc011cdi.1	+	23	3184	c.3001G>A	c.(3001-3003)GAG>AAG	p.E1001K	HERC6_uc011cdj.1_Missense_Mutation_p.E965K|HERC6_uc011cdk.1_RNA|HERC6_uc011cdl.1_RNA	NM_017912	NP_060382	Q8IVU3	HERC6_HUMAN	hect domain and RLD 6 isoform 1	1001	HECT.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytosol	ubiquitin-protein ligase activity			lung(3)|ovary(1)|kidney(1)	5		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000222)		GGAAAGAATGGAGGAAGCACT	0.428			NA											4	27					0	0	0.000602	0	0
C4orf37	285555	broad.mit.edu	37	4	98893504	98893504	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr4:98893504C>G	uc003htt.1	-	7	950	c.860G>C	c.(859-861)GGT>GCT	p.G287A		NM_174952	NP_777612	Q8N412	CD037_HUMAN	hypothetical protein LOC285555	287											0				OV - Ovarian serous cystadenocarcinoma(123;2.27e-08)		AACAGAAGAACCAAATGCACT	0.348			NA											7	45					0	0	0.001984	0	0
AIMP1	9255	broad.mit.edu	37	4	107249400	107249400	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr4:107249400G>C	uc011cfg.1	+	4	443	c.391G>C	c.(391-393)GGA>CGA	p.G131R	AIMP1_uc003hyg.2_Missense_Mutation_p.G131R|AIMP1_uc003hyh.2_Missense_Mutation_p.G155R	NM_001142415	NP_001135887	Q12904	AIMP1_HUMAN	small inducible cytokine subfamily E, member 1	131	Interaction with HSP90B1 (By similarity).|Required for endothelial cell migration.				angiogenesis|apoptosis|cell adhesion|cell-cell signaling|chemotaxis|glucose metabolic process|inflammatory response|leukocyte migration|negative regulation of endothelial cell proliferation|signal transduction|tRNA aminoacylation for protein translation	aminoacyl-tRNA synthetase multienzyme complex|cytosol|endoplasmic reticulum|extracellular space|Golgi apparatus|nucleus|transport vesicle	cell surface binding|cytokine activity|protein homodimerization activity|tRNA binding				0						TGAAAAGAAAGGTATTTTTGA	0.318			NA											4	18					0	0	0.009096	0	0
C4orf21	55345	broad.mit.edu	37	4	113540185	113540185	+	Missense_Mutation	SNP	A	A	T			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr4:113540185A>T	uc003iau.2	-	6	1224	c.1013T>A	c.(1012-1014)ATA>AAA	p.I338K	C4orf21_uc003iaw.2_Missense_Mutation_p.I338K	NM_018392	NP_060862	Q6ZU11	YD002_HUMAN	prematurely terminated mRNA decay factor-like	Error:Variant_position_missing_in_Q6ZU11_after_alignment						integral to membrane	zinc ion binding				0		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.000676)		AGAAGAATGTATAGGTGAACT	0.358			NA											12	121					0	0	0.001368	0	0
ANK2	287	broad.mit.edu	37	4	114278877	114278877	+	Missense_Mutation	SNP	A	A	G			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr4:114278877A>G	uc003ibe.3	+	38	9203	c.9103A>G	c.(9103-9105)ATC>GTC	p.I3035V	ANK2_uc003ibd.3_Intron|ANK2_uc003ibf.3_Intron|ANK2_uc011cgc.1_Intron|ANK2_uc003ibg.3_Intron|ANK2_uc003ibh.3_Intron|ANK2_uc011cgd.1_Missense_Mutation_p.I337V|ANK2_uc011cgb.1_Missense_Mutation_p.I3050V	NM_001148	NP_001139	Q01484	ANK2_HUMAN	ankyrin 2 isoform 1	3002					axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding|protein binding			central_nervous_system(7)|ovary(3)|large_intestine(2)|breast(1)|skin(1)	14		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		CAAAGTCATCATCACAAAAAC	0.413			NA											24	159					0	0	0.00278	0	0
ANK2	287	broad.mit.edu	37	4	114279344	114279344	+	Silent	SNP	A	A	T			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr4:114279344A>T	uc003ibe.3	+	38	9670	c.9570A>T	c.(9568-9570)GTA>GTT	p.V3190V	ANK2_uc003ibd.3_Intron|ANK2_uc003ibf.3_Intron|ANK2_uc011cgc.1_Intron|ANK2_uc003ibg.3_Intron|ANK2_uc003ibh.3_Intron|ANK2_uc011cgd.1_Silent_p.V492V|ANK2_uc011cgb.1_Silent_p.V3205V	NM_001148	NP_001139	Q01484	ANK2_HUMAN	ankyrin 2 isoform 1	3157					axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding|protein binding			central_nervous_system(7)|ovary(3)|large_intestine(2)|breast(1)|skin(1)	14		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		GTGAGGAAGTAGAGGAAATAC	0.458			NA											8	60					0	0	0.006214	0	0
FAT4	79633	broad.mit.edu	37	4	126411519	126411519	+	Silent	SNP	C	C	A	rs138057366	byFrequency	TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr4:126411519C>A	uc003ifj.3	+	17	13542	c.13542C>A	c.(13540-13542)ACC>ACA	p.T4514T	FAT4_uc011cgp.1_Silent_p.T2755T|FAT4_uc003ifi.1_Silent_p.T1991T	NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	4514	Helical; (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18						GCTGCGCAACCGTCTTGGCCC	0.567			NA											20	99					2.37509e-13	4.00676e-13	0.010504	1	0
GALNTL6	442117	broad.mit.edu	37	4	173269702	173269702	+	Silent	SNP	C	C	T			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr4:173269702C>T	uc003isv.2	+	5	1151	c.415C>T	c.(415-417)CTG>TTG	p.L139L		NM_001034845	NP_001030017	Q49A17	GLTL6_HUMAN	N-acetylgalactosaminyltransferase-like 6	139	Catalytic subdomain A.|Lumenal (Potential).					Golgi membrane|integral to membrane	metal ion binding|polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			breast(2)|ovary(1)|skin(1)	4						TCTGGAAAGGCTGCCAAACAC	0.398			NA											20	106					0	0	0.004656	0	0
FASTKD3	79072	broad.mit.edu	37	5	7866922	7866922	+	Silent	SNP	G	G	T			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr5:7866922G>T	uc003jeb.2	-	2	1412	c.1275C>A	c.(1273-1275)GCC>GCA	p.A425A	FASTKD3_uc011cmp.1_Silent_p.A127A|FASTKD3_uc003jec.2_Intron|MTRR_uc010itn.1_5'Flank|MTRR_uc003jee.3_5'Flank|MTRR_uc003jed.2_5'Flank|MTRR_uc003jef.3_5'Flank|MTRR_uc003jeg.3_5'Flank|MTRR_uc010ito.2_5'Flank	NM_024091	NP_076996	Q14CZ7	FAKD3_HUMAN	FAST kinase domains 3	425					apoptosis|cellular respiration	mitochondrion	ATP binding|protein kinase activity			ovary(2)|breast(1)|pancreas(1)	4						ATAAAGCAGAGGCATTTGGTG	0.348			NA											11	139					3.07112e-06	3.97045e-06	0.000978	1	0
PRDM9	56979	broad.mit.edu	37	5	23527621	23527621	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr5:23527621G>T	uc003jgo.2	+	11	2606	c.2424G>T	c.(2422-2424)GAG>GAT	p.E808D		NM_020227	NP_064612	Q9NQV7	PRDM9_HUMAN	PR domain containing 9	808	C2H2-type 12.				meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleoplasm	histone-lysine N-methyltransferase activity|nucleic acid binding|zinc ion binding			ovary(3)|large_intestine(2)|pancreas(1)	6						TCTGCAGGGAGTGTGGGCGGG	0.577			NA								HNSCC(3;0.000094)			11	261					1.08611e-07	1.46819e-07	0.000978	1	0
ADAMTS12	81792	broad.mit.edu	37	5	33662100	33662100	+	Missense_Mutation	SNP	A	A	T			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr5:33662100A>T	uc003jia.1	-	6	1124	c.961T>A	c.(961-963)TTC>ATC	p.F321I	ADAMTS12_uc010iuq.1_Missense_Mutation_p.F321I	NM_030955	NP_112217	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1	321	Peptidase M12B.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|kidney(1)	9						CACTTGCAGAAGCTAGACAGT	0.483			NA								HNSCC(64;0.19)			53	76					0	0	0.00361	0	0
UTP15	84135	broad.mit.edu	37	5	72863231	72863231	+	Missense_Mutation	SNP	A	A	T			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr5:72863231A>T	uc003kcw.1	+	2	285	c.62A>T	c.(61-63)CAA>CTA	p.Q21L	UTP15_uc011cso.1_Missense_Mutation_p.Q21L|UTP15_uc011csp.1_Intron|UTP15_uc010ize.1_Missense_Mutation_p.Q21L|ANKRA2_uc003kcu.1_5'Flank|ANKRA2_uc003kcv.2_5'Flank	NM_032175	NP_115551	Q8TED0	UTP15_HUMAN	UTP15, U3 small nucleolar ribonucleoprotein,	21					rRNA processing	cytoplasm|nucleolus					0		Lung NSC(167;0.00405)|Ovarian(174;0.0129)		OV - Ovarian serous cystadenocarcinoma(47;7.76e-55)		AAAATCACCCAAGATACACTG	0.378			NA											20	77					0	0	0.008871	0	0
CRHBP	1393	broad.mit.edu	37	5	76249973	76249973	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr5:76249973C>A	uc003ker.2	+	3	575	c.295C>A	c.(295-297)CAG>AAG	p.Q99K	CRHBP_uc010izx.2_Missense_Mutation_p.Q99K	NM_001882	NP_001873	P24387	CRHBP_HUMAN	corticotropin releasing hormone binding protein	99					female pregnancy|learning or memory|signal transduction	soluble fraction					0		all_lung(232;0.000414)|Lung NSC(167;0.0011)|Ovarian(174;0.0129)|Prostate(461;0.11)		OV - Ovarian serous cystadenocarcinoma(54;2.17e-51)|Epithelial(54;8.79e-46)|all cancers(79;2.49e-41)		CCACTACGACCAGGTCTCCAT	0.657			NA											6	80					0.00198382	0.00218378	0.001984	1	0
CMYA5	202333	broad.mit.edu	37	5	79026350	79026350	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr5:79026350G>T	uc003kgc.2	+	2	1834	c.1762G>T	c.(1762-1764)GTT>TTT	p.V588F		NM_153610	NP_705838	Q8N3K9	CMYA5_HUMAN	cardiomyopathy associated 5	588	Glu-rich.					perinuclear region of cytoplasm				ovary(6)|pancreas(2)|lung(1)	9		Lung NSC(167;0.00296)|all_lung(232;0.00327)|Ovarian(174;0.0262)		OV - Ovarian serous cystadenocarcinoma(54;9.85e-46)|Epithelial(54;3.38e-40)|all cancers(79;3.43e-35)		AATTGCATCTGTTTCTACTGG	0.423			NA											64	360					4.60868e-44	9.15121e-44	0.00361	1	0
PCSK1	5122	broad.mit.edu	37	5	95761538	95761538	+	Nonsense_Mutation	SNP	G	G	A			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr5:95761538G>A	uc003kls.1	-	3	588	c.382C>T	c.(382-384)CAG>TAG	p.Q128*		NM_000439	NP_000430	P29120	NEC1_HUMAN	proprotein convertase subtilisin/kexin type 1	128	Catalytic.				cell-cell signaling|cellular nitrogen compound metabolic process|energy reserve metabolic process|hormone biosynthetic process|peptide biosynthetic process|peptide hormone processing|regulation of insulin secretion	extracellular space|stored secretory granule|transport vesicle	serine-type endopeptidase activity			ovary(2)	2		all_cancers(142;2.67e-06)|all_epithelial(76;6.92e-09)|all_lung(232;0.00307)|Lung NSC(167;0.00452)|Ovarian(225;0.0112)|Colorectal(57;0.0341)|Breast(839;0.244)		all cancers(79;3.44e-16)	Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	TACCATTGCTGATTCCACATG	0.408			NA											7	41					0	0	0.00308	0	0
TSLP	85480	broad.mit.edu	37	5	110407675	110407675	+	Nonsense_Mutation	SNP	C	C	A			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr5:110407675C>A	uc003kpb.2	+	1	286	c.87C>A	c.(85-87)TAC>TAA	p.Y29*	TSLP_uc003kpa.2_RNA|TSLP_uc010jbt.1_5'Flank	NM_033035	NP_149024	Q969D9	TSLP_HUMAN	thymic stromal lymphopoietin isoform 1	29						extracellular space	cytokine activity				0		all_cancers(142;2.72e-05)|all_epithelial(76;4.39e-07)|Prostate(80;0.00955)|Lung NSC(167;0.0417)|Ovarian(225;0.0443)|Colorectal(57;0.0464)|all_lung(232;0.0507)|Breast(839;0.244)		OV - Ovarian serous cystadenocarcinoma(64;1.24e-08)|Epithelial(69;1.54e-07)|all cancers(49;1.73e-05)|COAD - Colon adenocarcinoma(37;0.109)		TGTTAACTTACGACTTCACTA	0.383			NA											21	161					1.96292e-10	3.05098e-10	0.010504	1	0
AFF4	27125	broad.mit.edu	37	5	132232314	132232314	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr5:132232314C>T	uc003kyd.2	-	11	2416	c.2008G>A	c.(2008-2010)GAG>AAG	p.E670K	AFF4_uc011cxk.1_Missense_Mutation_p.E348K|AFF4_uc003kye.1_Missense_Mutation_p.E670K	NM_014423	NP_055238	Q9UHB7	AFF4_HUMAN	ALL1 fused gene from 5q31	670					transcription from RNA polymerase II promoter	mitochondrion|nucleolus	protein binding|sequence-specific DNA binding transcription factor activity			ovary(2)|kidney(2)|skin(1)	5		all_cancers(142;0.145)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			CTATTGCTCTCGGGGTACTTA	0.443	Ovarian(126;889 1733 2942 10745 11605)		NA											12	105					0	0	0.001855	0	0
TCERG1	10915	broad.mit.edu	37	5	145838723	145838723	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr5:145838723G>T	uc003lob.2	+	4	755	c.715G>T	c.(715-717)GCC>TCC	p.A239S	TCERG1_uc003loc.2_Missense_Mutation_p.A239S|TCERG1_uc011dbt.1_Missense_Mutation_p.A239S	NM_006706	NP_006697	O14776	TCRG1_HUMAN	transcription elongation regulator 1 isoform 1	239	Potential.|Ala/Gln-rich.				regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleus	protein binding|transcription coactivator activity			ovary(1)|skin(1)	2		Lung NSC(249;0.00188)|all_lung(500;0.00307)|all_neural(839;0.0424)|Breast(839;0.0743)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			tcaggcccaggcccaggctca	0.194			NA											12	41					5.16669e-11	8.15276e-11	0.000978	1	0
SLIT3	6586	broad.mit.edu	37	5	168180932	168180932	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr5:168180932G>A	uc003mab.2	-	17	2186	c.1766C>T	c.(1765-1767)ACA>ATA	p.T589I	SLIT3_uc010jjg.2_Missense_Mutation_p.T589I	NM_003062	NP_003053	O75094	SLIT3_HUMAN	slit homolog 3 precursor	589	LRR 14.				apoptosis involved in luteolysis|axon extension involved in axon guidance|cellular response to hormone stimulus|negative chemotaxis|negative regulation of cell growth|negative regulation of chemokine-mediated signaling pathway|response to cortisol stimulus|Roundabout signaling pathway	extracellular space|mitochondrion	calcium ion binding|Roundabout binding			ovary(3)|skin(1)	4	Renal(175;0.000159)|Lung NSC(126;0.0174)|all_lung(126;0.0392)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			CTGGTTCCCTGTCAGCATCAG	0.572	Ovarian(29;311 847 10864 17279 24903)		NA											11	34					0	0	0.000978	0	0
FOXI1	2299	broad.mit.edu	37	5	169533452	169533452	+	Missense_Mutation	SNP	A	A	T			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr5:169533452A>T	uc003mai.3	+	1	536	c.491A>T	c.(490-492)AAG>ATG	p.K164M	FOXI1_uc003maj.3_Missense_Mutation_p.K164M	NM_012188	NP_036320	Q12951	FOXI1_HUMAN	forkhead box I1 isoform a	164	Fork-head.				epidermal cell fate specification|otic placode formation|pattern specification process|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|transcription regulatory region DNA binding			breast(3)|central_nervous_system(1)	4	Renal(175;0.000159)|Lung NSC(126;0.0267)|all_lung(126;0.04)	Medulloblastoma(196;0.0109)|all_neural(177;0.0298)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			AACAAGAGCAAGGCCGGCTGG	0.607			NA							Pendred_syndrome				6	24					0	0	0.00308	0	0
NSD1	64324	broad.mit.edu	37	5	176721186	176721186	+	Missense_Mutation	SNP	T	T	G			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr5:176721186T>G	uc003mfr.3	+	23	6955	c.6817T>G	c.(6817-6819)TGT>GGT	p.C2273G	NSD1_uc003mft.3_Missense_Mutation_p.C2004G|NSD1_uc011dfx.1_Missense_Mutation_p.C1921G	NM_022455	NP_071900	Q96L73	NSD1_HUMAN	nuclear receptor binding SET domain protein 1	2273	Pro-rich.				negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	androgen receptor binding|chromatin binding|estrogen receptor binding|histone methyltransferase activity (H3-K36 specific)|histone methyltransferase activity (H4-K20 specific)|ligand-dependent nuclear receptor binding|retinoid X receptor binding|thyroid hormone receptor binding|transcription corepressor activity|zinc ion binding			ovary(2)|kidney(1)	3	all_cancers(89;1.57e-05)|Renal(175;0.000269)|Lung NSC(126;0.00111)|all_lung(126;0.002)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)|Epithelial(233;0.198)	Kidney(146;0.235)		GGCAGGGACTTGTCAGAGGCC	0.522			NA	T	NUP98	AML		Sotos Syndrome		Beckwith-Wiedemann_syndrome|Sotos_syndrome|Weaver_syndrome	HNSCC(47;0.14)			28	213					0	0	0.002445	0	0
HDGFL1	154150	broad.mit.edu	37	6	22569972	22569972	+	Silent	SNP	G	G	C			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr6:22569972G>C	uc003nds.2	+	1	295	c.168G>C	c.(166-168)CTG>CTC	p.L56L		NM_138574	NP_612641	Q5TGJ6	HDGL1_HUMAN	hepatoma derived growth factor-like 1	56	PWWP.										0	Ovarian(93;0.163)					CCAAACGCCTGTTCCCGTACA	0.617			NA											8	58					0	0	0.006214	0	0
SLC17A1	6568	broad.mit.edu	37	6	25799037	25799037	+	Silent	SNP	T	T	C			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr6:25799037T>C	uc003nfh.3	-	12	1496	c.1380A>G	c.(1378-1380)AAA>AAG	p.K460K	SLC17A1_uc011djy.1_RNA|SLC17A1_uc010jqb.1_Silent_p.K458K|SLC17A1_uc010jqc.1_Silent_p.K404K	NM_005074	NP_005065	Q14916	NPT1_HUMAN	solute carrier family 17 (sodium phosphate),	460					sodium ion transport|urate metabolic process	integral to plasma membrane|membrane fraction	sodium-dependent phosphate transmembrane transporter activity|symporter activity			ovary(3)|pancreas(1)	4						GTTGTTTTTCTTTAGCCCAGT	0.423			NA											15	109					0	0	0.004007	0	0
NKAPL	222698	broad.mit.edu	37	6	28227314	28227314	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr6:28227314G>T	uc003nkt.2	+	1	217	c.165G>T	c.(163-165)TGG>TGT	p.W55C	ZKSCAN4_uc011dlb.1_5'Flank	NM_001007531	NP_001007532	Q5M9Q1	NKAPL_HUMAN	NFKB activating protein-like	55										upper_aerodigestive_tract(1)|ovary(1)	2						GGCCTCCTTGGAGTGAGTTGG	0.652			NA											16	117					1.56452e-12	2.56631e-12	0.007413	1	0
ZNF323	64288	broad.mit.edu	37	6	28294239	28294239	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr6:28294239C>A	uc003nla.2	-	4	1325	c.925G>T	c.(925-927)GGC>TGC	p.G309C	ZNF323_uc003nld.2_Missense_Mutation_p.G309C|ZNF323_uc010jra.2_Missense_Mutation_p.G309C|ZNF323_uc003nlb.2_Missense_Mutation_p.G150C|ZNF323_uc010jrb.2_Missense_Mutation_p.G150C|ZNF323_uc003nlc.2_Missense_Mutation_p.G309C	NM_001135216	NP_001128688	Q96LW9	ZN323_HUMAN	zinc finger protein 323	309	C2H2-type 3.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|skin(1)	2						CGAGTGAGGCCATTGCTGGCA	0.512	Colon(115;1052 1587 16954 47314 53012)		NA											42	233					1.15183e-24	2.20281e-24	0.009718	1	0
OR2J3	442186	broad.mit.edu	37	6	29079836	29079836	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr6:29079836C>A	uc011dll.1	+	1	169	c.169C>A	c.(169-171)CAT>AAT	p.H57N		NM_001005216	NP_001005216	O76001	OR2J3_HUMAN	olfactory receptor, family 2, subfamily J,	57	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						CCTGGACTCCCATCTGCACAC	0.458			NA											55	306					3.10202e-16	5.49809e-16	0.00361	1	0
ZFP57	346171	broad.mit.edu	37	6	29640787	29640787	+	Silent	SNP	C	C	T			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr6:29640787C>T	uc011dlw.1	-	4	1252	c.1101G>A	c.(1099-1101)CAG>CAA	p.Q367Q	ZFP57_uc003nnl.3_Silent_p.Q347Q	NM_001109809	NP_001103279	Q9NU63	ZFP57_HUMAN	zinc finger protein 57 homolog	283					DNA methylation involved in embryo development|regulation of gene expression by genetic imprinting|transcription, DNA-dependent		DNA binding|zinc ion binding			ovary(3)|skin(2)	5						ATCTGGCATCCTGACAGAGGG	0.498			NA											91	452					0	0	0.00361	0	0
HSPA1L	3305	broad.mit.edu	37	6	31777930	31777930	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr6:31777930G>A	uc003nxh.2	-	2	2003	c.1820C>T	c.(1819-1821)CCT>CTT	p.P607L	HSPA1L_uc010jte.2_Missense_Mutation_p.P607L	NM_005527	NP_005518	P34931	HS71L_HUMAN	heat shock 70kDa protein 1-like	607					response to unfolded protein		ATP binding			ovary(3)|pleura(1)|kidney(1)|skin(1)	6						TGTGATGATAGGGTTACACAT	0.493			NA											8	144					0	0	0.00308	0	0
TTBK1	84630	broad.mit.edu	37	6	43221047	43221047	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr6:43221047G>T	uc003ouq.1	+	4	554	c.275G>T	c.(274-276)AGG>ATG	p.R92M		NM_032538	NP_115927	Q5TCY1	TTBK1_HUMAN	tau tubulin kinase 1	92	Protein kinase.					cell junction|cytoplasm|nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			lung(4)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	9			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0125)|OV - Ovarian serous cystadenocarcinoma(102;0.0399)			CATGTGTGCAGGTTCATTGGC	0.527			NA											9	190					7.93312e-07	1.04849e-06	0.00245	1	0
TDRD6	221400	broad.mit.edu	37	6	46658183	46658183	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr6:46658183C>T	uc003oyj.2	+	1	2318	c.2318C>T	c.(2317-2319)ACA>ATA	p.T773I	TDRD6_uc010jze.2_Missense_Mutation_p.T767I	NM_001010870	NP_001010870	O60522	TDRD6_HUMAN	tudor domain containing 6	773					cell differentiation|multicellular organismal development|spermatogenesis	chromatoid body	nucleic acid binding			breast(3)|ovary(2)|skin(1)	6			Lung(136;0.192)			GTTGGAAGTACAGTAGAAGTC	0.398			NA											67	64					0	0	0.00361	0	0
PGK2	5232	broad.mit.edu	37	6	49754747	49754747	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr6:49754747C>T	uc003ozu.2	-	1	261	c.154G>A	c.(154-156)GAC>AAC	p.D52N		NM_138733	NP_620061	P07205	PGK2_HUMAN	phosphoglycerate kinase 2	52					glycolysis	cytosol	ATP binding|phosphoglycerate kinase activity			ovary(1)	1	Lung NSC(77;0.0402)					GCTCCATTGTCCAGGCAGTAC	0.463			NA											66	158					0	0	0.00361	0	0
GFRAL	389400	broad.mit.edu	37	6	55214930	55214930	+	Silent	SNP	A	A	C			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr6:55214930A>C	uc003pcm.1	+	4	443	c.357A>C	c.(355-357)ACA>ACC	p.T119T		NM_207410	NP_997293	Q6UXV0	GFRAL_HUMAN	GDNF family receptor alpha like precursor	119	Extracellular (Potential).					integral to membrane	receptor activity			ovary(1)|breast(1)	2	Lung NSC(77;0.0875)|Renal(3;0.122)		LUSC - Lung squamous cell carcinoma(124;0.23)			ATCTAACTACACGTTCCCATC	0.299			NA											6	23					0	0	0.001984	0	0
OOEP	441161	broad.mit.edu	37	6	74078997	74078997	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr6:74078997C>A	uc003pgu.3	-	2	302	c.302G>T	c.(301-303)CGT>CTT	p.R101L	OOEP_uc003pgv.3_Missense_Mutation_p.R46L	NM_001080507	NP_001073976	A6NGQ2	OOEP_HUMAN	oocyte expressed protein homolog	101	KH; atypical.					cytoplasm					0						ATTCTGTACACGGGGCCGCCC	0.557			NA											6	37					2.17888e-05	2.70729e-05	0.006214	1	0
TRDN	10345	broad.mit.edu	37	6	123892215	123892215	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr6:123892215C>T	uc003pzj.1	-	2	107	c.85G>A	c.(85-87)GGA>AGA	p.G29R	TRDN_uc003pzk.1_Missense_Mutation_p.G29R|TRDN_uc003pzl.1_Missense_Mutation_p.G29R|TRDN_uc010ken.2_Missense_Mutation_p.G29R|TRDN_uc010keo.1_Missense_Mutation_p.G29R	NM_006073	NP_006064	Q13061	TRDN_HUMAN	triadin	29	Cytoplasmic.				muscle contraction	integral to membrane|plasma membrane|sarcoplasmic reticulum membrane	receptor binding			ovary(1)	1				GBM - Glioblastoma multiforme(226;0.184)		AGCACTTTTCCGGGGGATTTG	0.453			NA											8	64					0	0	0.008291	0	0
THBS2	7058	broad.mit.edu	37	6	169626329	169626329	+	Silent	SNP	A	A	T			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr6:169626329A>T	uc003qwt.2	-	17	2732	c.2484T>A	c.(2482-2484)GGT>GGA	p.G828G		NM_003247	NP_003238	P35442	TSP2_HUMAN	thrombospondin 2 precursor	828	TSP type-3 5.				cell adhesion	extracellular region	calcium ion binding|heparin binding|protein binding|structural molecule activity			ovary(5)	5		Breast(66;1.78e-05)|Ovarian(120;0.0728)|Esophageal squamous(34;0.247)		OV - Ovarian serous cystadenocarcinoma(33;1.85e-21)|BRCA - Breast invasive adenocarcinoma(81;1.43e-06)|GBM - Glioblastoma multiforme(31;0.000379)		CCACACCGTCACCATCCGTGT	0.537	Esophageal Squamous(91;219 1934 18562 44706)		NA											16	78					0	0	0.007413	0	0
ABCA13	154664	broad.mit.edu	37	7	48684282	48684282	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr7:48684282G>C	uc003toq.2	+	61	15038	c.15013G>C	c.(15013-15015)GTT>CTT	p.V5005L	ABCA13_uc010kys.1_Missense_Mutation_p.V2080L|ABCA13_uc010kyt.1_RNA|ABCA13_uc010kyu.1_Missense_Mutation_p.V735L	NM_152701	NP_689914	Q86UQ4	ABCAD_HUMAN	ATP binding cassette, sub-family A (ABC1),	5005					transport	integral to membrane	ATP binding|ATPase activity			ovary(5)|central_nervous_system(4)|skin(1)	10						CTTGTTCAAAGTTATAGAGAA	0.323			NA											3	65					0	0	0.004672	0	0
ZNF716	441234	broad.mit.edu	37	7	57529005	57529005	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr7:57529005C>A	uc011kdi.1	+	4	950	c.838C>A	c.(838-840)CGC>AGC	p.R280S		NM_001159279	NP_001152751			zinc finger protein 716											ovary(2)	2						AGTCTTTAGCCGCTCAACACT	0.413			NA											10	28					4.68919e-08	6.50841e-08	0.008291	1	0
AKAP9	10142	broad.mit.edu	37	7	91609624	91609624	+	Missense_Mutation	SNP	A	A	T			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr7:91609624A>T	uc003ulg.2	+	3	553	c.328A>T	c.(328-330)ACA>TCA	p.T110S	AKAP9_uc003uld.3_Missense_Mutation_p.T110S|AKAP9_uc003ule.2_Missense_Mutation_p.T122S|AKAP9_uc003ulf.2_Missense_Mutation_p.T110S	NM_005751	NP_005742	Q99996	AKAP9_HUMAN	A-kinase anchor protein 9 isoform 2	122					G2/M transition of mitotic cell cycle|signal transduction|synaptic transmission|transport	centrosome|cytosol|Golgi apparatus	receptor binding			breast(7)|ovary(6)|lung(5)|skin(3)|large_intestine(2)|prostate(2)|central_nervous_system(1)	26	all_cancers(62;2.46e-09)|all_epithelial(64;4.42e-08)|Breast(17;0.00206)|all_lung(186;0.185)|all_hematologic(106;0.215)|Lung NSC(181;0.249)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)			AATTTCAACCACAGCAGATGA	0.234			NA	T	BRAF	papillary thyroid								4	55					0	0	0.000602	0	0
GATAD1	57798	broad.mit.edu	37	7	92080020	92080020	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr7:92080020C>G	uc003ulx.1	+	3	660	c.381C>G	c.(379-381)ATC>ATG	p.I127M	GATAD1_uc011khq.1_RNA	NM_021167	NP_066990	Q8WUU5	GATD1_HUMAN	GATA zinc finger domain containing 1	127							sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0	all_cancers(62;1.63e-10)|all_epithelial(64;8.33e-10)|Breast(17;0.00311)|all_lung(186;0.0498)|Lung NSC(181;0.0676)		STAD - Stomach adenocarcinoma(171;4.51e-05)|GBM - Glioblastoma multiforme(5;8.83e-05)|all cancers(6;0.000136)|Lung(22;0.123)|Epithelial(20;0.179)|LUSC - Lung squamous cell carcinoma(200;0.225)			CATAGCCCATCAAAGCTCCTG	0.398			NA											13	96					0	0	0.00245	0	0
SAMD9L	219285	broad.mit.edu	37	7	92762064	92762064	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr7:92762064C>A	uc003umh.1	-	5	4437	c.3221G>T	c.(3220-3222)GGA>GTA	p.G1074V	SAMD9L_uc003umj.1_Missense_Mutation_p.G1074V|SAMD9L_uc003umi.1_Missense_Mutation_p.G1074V|SAMD9L_uc010lfb.1_Missense_Mutation_p.G1074V|SAMD9L_uc003umk.1_Missense_Mutation_p.G1074V|SAMD9L_uc010lfc.1_Missense_Mutation_p.G1074V|SAMD9L_uc010lfd.1_Missense_Mutation_p.G1074V|SAMD9L_uc011khx.1_Intron	NM_152703	NP_689916	Q8IVG5	SAM9L_HUMAN	sterile alpha motif domain containing 9-like	1074										ovary(4)	4	all_cancers(62;4.15e-11)|all_epithelial(64;2.29e-10)|Breast(17;0.000675)|Lung NSC(181;0.0755)|all_lung(186;0.0989)		STAD - Stomach adenocarcinoma(171;0.000302)			TCGTCTACTTCCTGCACTCAA	0.413			NA											22	129					1.55795e-14	2.67168e-14	0.001882	1	0
GNG11	2791	broad.mit.edu	37	7	93555509	93555509	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr7:93555509G>T	uc003und.2	+	2	637	c.203G>T	c.(202-204)GGC>GTC	p.G68V		NM_004126	NP_004117	P61952	GBG11_HUMAN	guanine nucleotide binding protein gamma 11	68					cellular response to glucagon stimulus|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway	heterotrimeric G-protein complex	GTPase activity|signal transducer activity			kidney(1)	1	all_cancers(62;2.39e-10)|all_epithelial(64;1.54e-09)|Lung NSC(181;0.218)		STAD - Stomach adenocarcinoma(171;0.000967)			AAAGAAAAAGGCAGCTGTGTT	0.348			NA											9	101					2.17888e-05	2.70729e-05	0.006214	1	0
PPP1R9A	55607	broad.mit.edu	37	7	94791228	94791228	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr7:94791228G>C	uc003unp.2	+	5	1981	c.1699G>C	c.(1699-1701)GGT>CGT	p.G567R	PPP1R9A_uc010lfj.2_Missense_Mutation_p.G567R|PPP1R9A_uc011kif.1_Missense_Mutation_p.G567R|PPP1R9A_uc003unq.2_Missense_Mutation_p.G567R|PPP1R9A_uc011kig.1_Missense_Mutation_p.G567R	NM_017650	NP_060120	Q9ULJ8	NEB1_HUMAN	protein phosphatase 1, regulatory (inhibitor)	567	PDZ.					cell junction|synapse|synaptosome	actin binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	4	all_cancers(62;9.12e-11)|all_epithelial(64;4.34e-09)		STAD - Stomach adenocarcinoma(171;0.0031)			CAGCTTGGTGGGTGTGACACA	0.363			NA								HNSCC(28;0.073)			5	33					0	0	0.000602	0	0
TRRAP	8295	broad.mit.edu	37	7	98495465	98495465	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr7:98495465G>C	uc003upp.2	+	8	818	c.609G>C	c.(607-609)GAG>GAC	p.E203D	TRRAP_uc011kis.1_Missense_Mutation_p.E203D|TRRAP_uc003upr.2_5'Flank	NM_003496	NP_003487	Q9Y4A5	TRRAP_HUMAN	transformation/transcription domain-associated	203					histone deubiquitination|histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|PCAF complex|STAGA complex|transcription factor TFTC complex	phosphotransferase activity, alcohol group as acceptor|protein binding|transcription cofactor activity			ovary(9)|large_intestine(8)|central_nervous_system(6)|skin(6)|stomach(5)|upper_aerodigestive_tract(1)|lung(1)|liver(1)	37	all_cancers(62;6.96e-09)|all_epithelial(64;4.86e-09)|Lung NSC(181;0.01)|all_lung(186;0.016)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)			TCAACCCGGAGCGTGAGGACA	0.473			NA											28	146					0	0	0.009535	0	0
CYP3A5	1577	broad.mit.edu	37	7	99262907	99262907	+	Silent	SNP	A	A	G			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr7:99262907A>G	uc003urq.2	-	7	639	c.552T>C	c.(550-552)ATT>ATC	p.I184I	ZNF498_uc003urn.2_Intron|CYP3A5_uc003urp.2_Silent_p.I4I|CYP3A5_uc003urr.2_Silent_p.I71I|CYP3A5_uc011kiy.1_Silent_p.I174I|CYP3A5_uc003urs.2_Intron|CYP3A5_uc010lgg.2_Intron	NM_000777	NP_000768	P20815	CP3A5_HUMAN	cytochrome P450, family 3, subfamily A,	184					alkaloid catabolic process|drug catabolic process|oxidative demethylation|steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding				0	all_epithelial(64;2.77e-08)|Lung NSC(181;0.00396)|all_lung(186;0.00659)|Esophageal squamous(72;0.0166)				Alfentanil(DB00802)|Clopidogrel(DB00758)|Cyclosporine(DB00091)|Daunorubicin(DB00694)|Indinavir(DB00224)|Irinotecan(DB00762)|Ketoconazole(DB01026)|Lapatinib(DB01259)|Mephenytoin(DB00532)|Midazolam(DB00683)|Mifepristone(DB00834)|Phenytoin(DB00252)|Quinine(DB00468)|Saquinavir(DB01232)|Tacrolimus(DB00864)|Troleandomycin(DB01361)|Verapamil(DB00661)|Vincristine(DB00541)	ATGTGCCAGTAATCACATCCA	0.428			NA											21	124					0	0	0.00278	0	0
MYL10	93408	broad.mit.edu	37	7	101265451	101265451	+	Nonsense_Mutation	SNP	C	C	A			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr7:101265451C>A	uc003uyr.2	-	5	557	c.379G>T	c.(379-381)GAG>TAG	p.E127*		NM_138403	NP_612412	Q9BUA6	MYL10_HUMAN	myosin, light chain 10, regulatory	127						mitochondrion	calcium ion binding			ovary(1)|breast(1)	2						ACCATGGCCTCCAGTTCCTCG	0.597	Esophageal Squamous(24;575 709 17516 40384 51639)		NA											10	67					1.5842e-08	2.25152e-08	0.001855	1	0
LAMB1	3912	broad.mit.edu	37	7	107603427	107603427	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr7:107603427C>A	uc003vew.2	-	15	2115	c.1780G>T	c.(1780-1782)GGG>TGG	p.G594W	LAMB1_uc003vev.2_Missense_Mutation_p.G618W|LAMB1_uc003vex.2_Missense_Mutation_p.G594W|LAMB1_uc010ljn.1_Missense_Mutation_p.G680W	NM_002291	NP_002282	P07942	LAMB1_HUMAN	laminin, beta 1 precursor	594	Laminin IV type B.				axon guidance|odontogenesis|positive regulation of cell migration|positive regulation of epithelial cell proliferation|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-2 complex|laminin-8 complex|perinuclear region of cytoplasm	extracellular matrix structural constituent			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	8					Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	AAATAAGCCCCTTCAGGCACT	0.502			NA											6	225					1.06961e-07	1.45062e-07	0.00308	1	0
PTPRZ1	5803	broad.mit.edu	37	7	121651440	121651440	+	Silent	SNP	C	C	A			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr7:121651440C>A	uc003vjy.2	+	12	2735	c.2340C>A	c.(2338-2340)ATC>ATA	p.I780I	PTPRZ1_uc003vjz.2_Intron|PTPRZ1_uc011knt.1_Intron	NM_002851	NP_002842	P23471	PTPRZ_HUMAN	protein tyrosine phosphatase, receptor-type,	780	Extracellular (Potential).				central nervous system development	integral to plasma membrane	protein binding|protein tyrosine/threonine phosphatase activity|transmembrane receptor protein tyrosine phosphatase activity			ovary(3)|large_intestine(2)|lung(2)|central_nervous_system(1)|kidney(1)	9						ACAATCAGATCCTCAACACTA	0.473			NA											16	267					4.14922e-12	6.7001e-12	0.004007	1	0
CLCN1	1180	broad.mit.edu	37	7	143013364	143013364	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr7:143013364C>A	uc003wcr.1	+	1	146	c.59C>A	c.(58-60)CCC>CAC	p.P20H	CLCN1_uc011ktc.1_5'UTR	NM_000083	NP_000074	P35523	CLCN1_HUMAN	chloride channel 1, skeletal muscle	20	Cytoplasmic (By similarity).				muscle contraction	chloride channel complex|integral to plasma membrane	voltage-gated chloride channel activity			ovary(2)|breast(1)|central_nervous_system(1)|skin(1)	5	Melanoma(164;0.205)					GGTAGTGACCCCCAGTACCAG	0.642			NA											25	208					4.4004e-07	5.8531e-07	0.00333	1	0
ABCB8	11194	broad.mit.edu	37	7	150732736	150732736	+	Silent	SNP	G	G	C			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr7:150732736G>C	uc003wil.3	+	7	978	c.885G>C	c.(883-885)ACG>ACC	p.T295T	ABCB8_uc003wii.2_Silent_p.T315T|ABCB8_uc003wij.3_Silent_p.T278T|ABCB8_uc010lpw.1_Silent_p.T97T|ABCB8_uc010lpx.2_Silent_p.T278T|ABCB8_uc011kvd.1_Silent_p.T190T|ABCB8_uc003wim.3_Silent_p.T73T|ABCB8_uc003wik.3_Silent_p.T278T	NM_007188	NP_009119	Q9NUT2	ABCB8_HUMAN	ATP-binding cassette, sub-family B, member 8	295	ABC transmembrane type-1.					ATP-binding cassette (ABC) transporter complex|integral to membrane|membrane fraction|mitochondrial inner membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(2)|upper_aerodigestive_tract(1)	3			OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		CACGCCTCACGCTGCTGCTGA	0.657			NA											11	103					0	0	0.001855	0	0
ABCF2	10061	broad.mit.edu	37	7	150915920	150915920	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr7:150915920C>A	uc003wjp.2	-	9	1168	c.1057G>T	c.(1057-1059)GCC>TCC	p.A353S	ABCF2_uc003wjo.1_Missense_Mutation_p.A353S	NM_007189	NP_009120	Q9UG63	ABCF2_HUMAN	ATP-binding cassette, sub-family F, member 2	353						ATP-binding cassette (ABC) transporter complex|mitochondrial envelope	ATP binding|ATPase activity|transporter activity			central_nervous_system(1)	1			OV - Ovarian serous cystadenocarcinoma(82;0.00448)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		GCCTGCCGGGCCAGCTTGGCA	0.453			NA											25	131					2.81731e-10	4.33032e-10	0.002096	1	0
HTR5A	3361	broad.mit.edu	37	7	154862977	154862977	+	Missense_Mutation	SNP	T	T	C			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr7:154862977T>C	uc003wlu.1	+	1	432	c.368T>C	c.(367-369)CTT>CCT	p.L123P	uc011kvt.1_Missense_Mutation_p.S13G|uc003wlt.2_Missense_Mutation_p.S13G	NM_024012	NP_076917	P47898	5HT5A_HUMAN	5-hydroxytryptamine receptor 5A	123	Helical; Name=3; (By similarity).					integral to plasma membrane	serotonin receptor activity			ovary(2)|large_intestine(1)	3	all_neural(206;0.119)	all_hematologic(28;0.0592)	OV - Ovarian serous cystadenocarcinoma(82;0.0238)	UCEC - Uterine corpus endometrioid carcinoma (81;0.171)		TGCGACGTGCTTTGCTGCACG	0.667			NA											10	32					0	0	0.001368	0	0
PTPRN2	5799	broad.mit.edu	37	7	157929352	157929352	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr7:157929352G>T	uc003wno.2	-	8	1289	c.1168C>A	c.(1168-1170)CAA>AAA	p.Q390K	PTPRN2_uc003wnp.2_Missense_Mutation_p.Q373K|PTPRN2_uc003wnq.2_Missense_Mutation_p.Q390K|PTPRN2_uc003wnr.2_Missense_Mutation_p.Q352K|PTPRN2_uc011kwa.1_Missense_Mutation_p.Q413K	NM_002847	NP_002838	Q92932	PTPR2_HUMAN	protein tyrosine phosphatase, receptor type, N	390	Extracellular (Potential).					integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			ovary(4)|large_intestine(1)|pleura(1)|skin(1)	7	all_neural(206;0.181)	all_cancers(7;8.99e-13)|all_epithelial(9;2.4e-06)|all_hematologic(28;0.0155)|Breast(660;0.132)	OV - Ovarian serous cystadenocarcinoma(82;0.00463)	STAD - Stomach adenocarcinoma(7;0.0875)		CTTACCTCTTGGTAAAGTCTA	0.413			NA											24	114					3.73148e-12	6.04907e-12	0.007291	1	0
CSMD1	64478	broad.mit.edu	37	8	2949091	2949091	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr8:2949091C>T	uc011kwk.1	-	48	7625	c.7235G>A	c.(7234-7236)CGC>CAC	p.R2412H	CSMD1_uc011kwj.1_Missense_Mutation_p.R1741H|CSMD1_uc010lrg.2_Missense_Mutation_p.R480H	NM_033225	NP_150094	Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1 precursor	2412	CUB 14.|Extracellular (Potential).					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		AGTGGACCAGCGGAGATATAA	0.383			NA											8	30					0	0	0.006214	0	0
RP1L1	94137	broad.mit.edu	37	8	10470413	10470413	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr8:10470413C>A	uc003wtc.2	-	4	1424	c.1195G>T	c.(1195-1197)GGG>TGG	p.G399W		NM_178857	NP_849188	Q8IWN7	RP1L1_HUMAN	retinitis pigmentosa 1-like 1	399					intracellular signal transduction					ovary(4)|breast(3)|central_nervous_system(1)	8				COAD - Colon adenocarcinoma(149;0.0811)		CCTGGCTGCCCGCCTCGGCCA	0.657			NA											11	102					0.000151284	0.00017938	0.001855	1	0
C8orf79	57604	broad.mit.edu	37	8	12878877	12878877	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr8:12878877C>A	uc010lsq.2	+	5	1181	c.689C>A	c.(688-690)TCT>TAT	p.S230Y	C8orf79_uc011kxw.1_Intron|C8orf79_uc003wwj.3_Missense_Mutation_p.S143Y|C8orf79_uc010lsr.2_Missense_Mutation_p.S104Y	NM_020844	NP_065895	Q9P272	K1456_HUMAN	hypothetical protein LOC57604 isoform 1	230							methyltransferase activity				0						GCAAATATTTCTAAGGAAGGC	0.423			NA											10	128					0.00136819	0.00153046	0.001368	1	0
CNOT7	29883	broad.mit.edu	37	8	17090038	17090038	+	Missense_Mutation	SNP	T	T	A			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr8:17090038T>A	uc003wxf.1	-	6	795	c.627A>T	c.(625-627)TTA>TTT	p.L209F	CNOT7_uc003wxg.1_Missense_Mutation_p.L209F|CNOT7_uc003wxh.1_Missense_Mutation_p.L209F	NM_013354	NP_037486	Q9UIV1	CNOT7_HUMAN	CCR4-NOT transcription complex, subunit 7	209					carbohydrate metabolic process|nuclear-transcribed mRNA poly(A) tail shortening	CCR4-NOT complex|cytoplasmic mRNA processing body|cytosol	nucleic acid binding|protein binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			central_nervous_system(1)	1				Colorectal(111;0.0523)|COAD - Colon adenocarcinoma(73;0.209)		CCACCTCCTGTAATCCACCCT	0.378			NA											15	167					0	0	0.004007	0	0
CNOT7	29883	broad.mit.edu	37	8	17090042	17090042	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr8:17090042C>A	uc003wxf.1	-	6	791	c.623G>T	c.(622-624)GGA>GTA	p.G208V	CNOT7_uc003wxg.1_Missense_Mutation_p.G208V|CNOT7_uc003wxh.1_Missense_Mutation_p.G208V	NM_013354	NP_037486	Q9UIV1	CNOT7_HUMAN	CCR4-NOT transcription complex, subunit 7	208					carbohydrate metabolic process|nuclear-transcribed mRNA poly(A) tail shortening	CCR4-NOT complex|cytoplasmic mRNA processing body|cytosol	nucleic acid binding|protein binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			central_nervous_system(1)	1				Colorectal(111;0.0523)|COAD - Colon adenocarcinoma(73;0.209)		CTCCTGTAATCCACCCTAGAA	0.368			NA											15	159					6.72482e-11	1.05712e-10	0.003163	1	0
AGPAT6	137964	broad.mit.edu	37	8	41476485	41476485	+	Silent	SNP	G	G	A			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr8:41476485G>A	uc003xnz.2	+	12	2190	c.1251G>A	c.(1249-1251)GTG>GTA	p.V417V		NM_178819	NP_848934	Q86UL3	GPAT4_HUMAN	lysophosphatidic acid acyltransferase zeta	417					acyl-CoA metabolic process|lactation|phosphatidylcholine biosynthetic process|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane|membrane fraction	glycerol-3-phosphate O-acyltransferase activity				0	Ovarian(28;0.00769)|Colorectal(14;0.0202)|Lung SC(25;0.211)	all_lung(54;0.0131)|Lung NSC(58;0.0363)|Hepatocellular(245;0.0462)|Esophageal squamous(32;0.0844)	OV - Ovarian serous cystadenocarcinoma(14;0.00126)|Colorectal(10;0.0014)|Lung(22;0.00177)|LUSC - Lung squamous cell carcinoma(45;0.00392)|COAD - Colon adenocarcinoma(11;0.0147)			GAGGACTTGTGGACCTGCTGT	0.498			NA											12	58					0	0	0.000978	0	0
SNTG1	54212	broad.mit.edu	37	8	51362272	51362272	+	Silent	SNP	C	C	G			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr8:51362272C>G	uc010lxy.1	+	7	635	c.264C>G	c.(262-264)TCC>TCG	p.S88S	SNTG1_uc003xqs.1_Silent_p.S88S|SNTG1_uc010lxz.1_Silent_p.S88S|SNTG1_uc011ldl.1_RNA	NM_018967	NP_061840	Q9NSN8	SNTG1_HUMAN	syntrophin, gamma 1	88	PDZ.				cell communication	cytoplasm|cytoskeleton|nucleus|ruffle membrane|syntrophin complex	actin binding|protein C-terminus binding			ovary(5)	5		all_cancers(86;0.00754)|all_epithelial(80;9.76e-05)|Lung NSC(129;0.000865)|all_lung(136;0.00249)|Colorectal(162;0.22)				CAAAAATCTCCAAGGAACAAA	0.313			NA											5	27					0	0	0.000602	0	0
TRPA1	8989	broad.mit.edu	37	8	72942164	72942164	+	Missense_Mutation	SNP	T	T	A			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr8:72942164T>A	uc003xza.2	-	24	3084	c.2909A>T	c.(2908-2910)CAT>CTT	p.H970L	uc011lff.1_Intron|uc003xyy.2_Intron	NM_007332	NP_015628	O75762	TRPA1_HUMAN	ankyrin-like protein 1	970	Cytoplasmic (Potential).					integral to plasma membrane				ovary(4)|lung(1)|kidney(1)	6			Epithelial(68;0.223)		Menthol(DB00825)	CAATGATGCATGTTTCTGGAC	0.284			NA											16	61					0	0	0.004007	0	0
ZFHX4	79776	broad.mit.edu	37	8	77764254	77764254	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr8:77764254G>T	uc003yav.2	+	10	5349	c.4962G>T	c.(4960-4962)CAG>CAT	p.Q1654H	ZFHX4_uc003yau.1_Missense_Mutation_p.Q1699H|ZFHX4_uc003yaw.1_Missense_Mutation_p.Q1654H	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	1654	Gln-rich.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			TGCAACTACAGCACGAATTAC	0.438			NA								HNSCC(33;0.089)			7	89					5.4927e-09	7.99815e-09	0.004482	1	0
SLC7A13	157724	broad.mit.edu	37	8	87242421	87242421	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr8:87242421G>T	uc003ydq.1	-	1	184	c.86C>A	c.(85-87)GCA>GAA	p.A29E	SLC7A13_uc003ydr.1_Missense_Mutation_p.A29E	NM_138817	NP_620172	Q8TCU3	S7A13_HUMAN	solute carrier family 7, (cationic amino acid	29	Helical; Name=1; (Potential).					integral to membrane	amino acid transmembrane transporter activity			central_nervous_system(1)	1						AAAAATTCCTGCACCAATGAT	0.453			NA											8	94					0.000157383	0.000184503	0.00308	1	0
SNTB1	6641	broad.mit.edu	37	8	121706136	121706136	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr8:121706136C>A	uc010mdg.2	-	2	810	c.584G>T	c.(583-585)CGA>CTA	p.R195L	SNTB1_uc003ype.2_Missense_Mutation_p.R195L	NM_021021	NP_066301	Q13884	SNTB1_HUMAN	basic beta 1 syntrophin	195	PH 1.|PDZ.				muscle contraction	cell junction|cytoplasm|cytoskeleton|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|calmodulin binding			skin(5)	5	Lung NSC(37;4.46e-09)|Ovarian(258;0.0254)|Hepatocellular(40;0.0997)		STAD - Stomach adenocarcinoma(47;0.00503)			CGTGGCTTCTCGCATGTACTT	0.483			NA											11	76					0.00185496	0.00206938	0.001855	1	0
TG	7038	broad.mit.edu	37	8	133953768	133953768	+	Silent	SNP	C	C	A			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr8:133953768C>A	uc003ytw.2	+	26	5255	c.5214C>A	c.(5212-5214)GTC>GTA	p.V1738V	TG_uc010mdw.2_Silent_p.V497V|TG_uc011ljb.1_Intron	NM_003235	NP_003226	P01266	THYG_HUMAN	thyroglobulin precursor	1738	Type IIIB.				hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			ovary(8)|breast(4)|pancreas(1)|central_nervous_system(1)|skin(1)	15	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		ATGGCTTCGTCCTCACACAGG	0.542			NA											13	79					0.000308642	0.00035481	0.003163	1	0
FAM135B	51059	broad.mit.edu	37	8	139180236	139180236	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr8:139180236C>A	uc003yuy.2	-	12	1331	c.1160G>T	c.(1159-1161)AGC>ATC	p.S387I	FAM135B_uc003yux.2_Missense_Mutation_p.S288I|FAM135B_uc003yuz.2_RNA	NM_015912	NP_056996	Q49AJ0	F135B_HUMAN	hypothetical protein LOC51059	387										ovary(7)|skin(2)	9	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			CGGGGGCATGCTAGTGAGGTA	0.607			NA								HNSCC(54;0.14)			32	152					1.62565e-12	2.65608e-12	0.002445	1	0
SPATC1	375686	broad.mit.edu	37	8	145095635	145095635	+	Missense_Mutation	SNP	T	T	A			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr8:145095635T>A	uc011lkw.1	+	3	1035	c.933T>A	c.(931-933)AGT>AGA	p.S311R	SPATC1_uc011lkx.1_Missense_Mutation_p.S311R	NM_198572	NP_940974	Q76KD6	SPERI_HUMAN	spermatogenesis and centriole associated 1	311										ovary(1)|central_nervous_system(1)	2	all_cancers(97;8.2e-11)|all_epithelial(106;1.1e-09)|Lung NSC(106;5.89e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;6.79e-41)|Epithelial(56;1.02e-39)|all cancers(56;3.67e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			CCCAGCCCAGTGCCGCCCAGG	0.393			NA											9	42					0	0	0.006214	0	0
HEATR7A	727957	broad.mit.edu	37	8	145235188	145235188	+	Silent	SNP	G	G	T			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr8:145235188G>T	uc003zbk.3	+	6	645	c.408G>T	c.(406-408)GGG>GGT	p.G136G	HEATR7A_uc003zbg.2_Silent_p.G136G|HEATR7A_uc003zbh.3_Silent_p.G136G|HEATR7A_uc003zbi.3_Silent_p.G136G|HEATR7A_uc011lla.1_Silent_p.G136G|HEATR7A_uc010mft.2_Silent_p.G136G	NM_032450	NP_115826	Q8NDA8	HTR7A_HUMAN	HEAT repeat containing 7A isoform 1	136							binding				0						TGCACCCTGGGACCCTGCCAC	0.697			NA											6	36					2.0095e-06	2.62246e-06	0.001984	1	0
KIAA1797	54914	broad.mit.edu	37	9	20717833	20717833	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr9:20717833G>T	uc003zog.1	+	5	461	c.98G>T	c.(97-99)GGT>GTT	p.G33V		NM_017794	NP_060264	Q5VW36	K1797_HUMAN	hypothetical protein LOC54914	33						integral to membrane	binding			ovary(8)|breast(1)|kidney(1)	10				GBM - Glioblastoma multiforme(3;2.1e-125)|Lung(42;2.76e-14)|LUSC - Lung squamous cell carcinoma(42;1.99e-11)		aaggaaaatggtttttcAGAA	0.264			NA											8	39					0.00621372	0.0066979	0.006214	1	0
KIAA1797	54914	broad.mit.edu	37	9	20926351	20926351	+	Missense_Mutation	SNP	A	A	T			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr9:20926351A>T	uc003zog.1	+	28	3376	c.3013A>T	c.(3013-3015)ACA>TCA	p.T1005S	KIAA1797_uc003zoh.1_Missense_Mutation_p.T441S	NM_017794	NP_060264	Q5VW36	K1797_HUMAN	hypothetical protein LOC54914	1005						integral to membrane	binding			ovary(8)|breast(1)|kidney(1)	10				GBM - Glioblastoma multiforme(3;2.1e-125)|Lung(42;2.76e-14)|LUSC - Lung squamous cell carcinoma(42;1.99e-11)		GGTACTTGATACACTCTTGGT	0.348			NA											13	103					0	0	0.001855	0	0
PTENP1	11191	broad.mit.edu	37	9	33676082	33676082	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr9:33676082G>A	uc003zth.3	-	1	1337	c.466C>T	c.(466-468)CCA>TCA	p.P156S		NR_023917				SubName: Full=Phosphatase and tensin homolog 2; Flags: Fragment;												0						AGTGCCACTGGTCTATAATCC	0.428			NA											16	183					0	0	0.003163	0	0
CCIN	881	broad.mit.edu	37	9	36170205	36170205	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr9:36170205G>T	uc003zzb.3	+	1	817	c.706G>T	c.(706-708)GCC>TCC	p.A236S		NM_005893	NP_005884	Q13939	CALI_HUMAN	calicin	236					cell differentiation|multicellular organismal development|spermatogenesis	cytoskeletal calyx	structural constituent of cytoskeleton			ovary(1)|skin(1)	2			STAD - Stomach adenocarcinoma(86;0.228)			GCTGGTGTTTGCCAGCAACAA	0.502			NA											10	38					4.68919e-08	6.50841e-08	0.008291	1	0
FAM75A2	642265	broad.mit.edu	37	9	39888226	39888226	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr9:39888226C>A	uc004abp.2	+	4	1242	c.1213C>A	c.(1213-1215)CAG>AAG	p.Q405K		NM_001040065	NP_001035154	Q5RGS2	F75A2_HUMAN	hypothetical protein LOC642265	405						integral to membrane					0				GBM - Glioblastoma multiforme(29;0.02)|Lung(182;0.0681)		TAGGCTCTGGCAGGAAAGTTT	0.532			NA											73	352					9.35349e-44	1.84843e-43	0.00361	1	0
FLJ46321	389763	broad.mit.edu	37	9	84606311	84606311	+	Missense_Mutation	SNP	G	G	T	rs147400236	by1000genomes	TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr9:84606311G>T	uc004amn.2	+	4	973	c.926G>T	c.(925-927)TGC>TTC	p.C309F		NM_001001670	NP_001001670	Q6ZQQ2	F75D1_HUMAN	hypothetical protein LOC389763	309						integral to membrane					0						CCGGAAGATTGCACTGTGACT	0.488			NA											32	356					2.08457e-15	3.63486e-15	0.002096	1	0
FLJ46321	389763	broad.mit.edu	37	9	84608122	84608122	+	Missense_Mutation	SNP	A	A	T			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr9:84608122A>T	uc004amn.2	+	4	2784	c.2737A>T	c.(2737-2739)AGG>TGG	p.R913W		NM_001001670	NP_001001670	Q6ZQQ2	F75D1_HUMAN	hypothetical protein LOC389763	913						integral to membrane					0						TTTCCGTATGAGGATGCTGTG	0.458			NA											12	47					0	0	0.000978	0	0
KIF27	55582	broad.mit.edu	37	9	86503486	86503486	+	Missense_Mutation	SNP	A	A	C			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr9:86503486A>C	uc004ana.2	-	8	2145	c.2001T>G	c.(1999-2001)ATT>ATG	p.I667M	KIF27_uc010mpw.2_Missense_Mutation_p.I667M|KIF27_uc010mpx.2_Missense_Mutation_p.I667M	NM_017576	NP_060046	Q86VH2	KIF27_HUMAN	kinesin family member 27	667					cilium assembly|microtubule-based movement	cilium|cytoplasm|microtubule	ATP binding|microtubule motor activity			lung(4)|skin(1)	5						CTGGCTTCTGAATCCATGAAC	0.348			NA											6	60					0	0	0.001984	0	0
NTRK2	4915	broad.mit.edu	37	9	87636230	87636230	+	Missense_Mutation	SNP	T	T	A			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr9:87636230T>A	uc004aoa.1	+	20	3285	c.2347T>A	c.(2347-2349)TAT>AAT	p.Y783N	NTRK2_uc004anz.1_Missense_Mutation_p.Y799N	NM_001018064	NP_001018074	Q16620	NTRK2_HUMAN	neurotrophic tyrosine kinase, receptor, type 2	783	Protein kinase.|Cytoplasmic (Potential).				activation of adenylate cyclase activity|cell differentiation|nerve growth factor receptor signaling pathway|nervous system development	integral to plasma membrane	ATP binding|neurotrophin receptor activity|transmembrane receptor protein tyrosine kinase activity			lung(11)|central_nervous_system(1)|breast(1)|skin(1)|ovary(1)|liver(1)	16						CCAGGAGGTGTATGAGCTGAT	0.572			NA								TSP Lung(25;0.17)			8	63					0	0	0.006214	0	0
TMEFF1	8577	broad.mit.edu	37	9	103279049	103279049	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr9:103279049G>T	uc004baz.1	+	5	666	c.556G>T	c.(556-558)GTT>TTT	p.V186F	TMEFF1_uc004bay.1_Missense_Mutation_p.V260F	NM_003692	NP_003683	Q8IYR6	TEFF1_HUMAN	transmembrane protein with EGF-like and two	186	Kazal-like 2.|Extracellular (Potential).				multicellular organismal development	integral to membrane|plasma membrane					0		Acute lymphoblastic leukemia(62;0.0452)				TGCAGAAAATGTTGGGTGAGT	0.398			NA											11	64					1.5842e-08	2.25152e-08	0.001855	1	0
PALM2-AKAP2	445815	broad.mit.edu	37	9	112898590	112898590	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr9:112898590C>A	uc004bei.2	+	9	1654	c.1462C>A	c.(1462-1464)CAT>AAT	p.H488N	PALM2-AKAP2_uc004bek.3_Missense_Mutation_p.H256N|PALM2-AKAP2_uc004bej.3_Missense_Mutation_p.H256N|PALM2-AKAP2_uc004bel.1_Missense_Mutation_p.H66N|AKAP2_uc011lwi.1_Missense_Mutation_p.H114N|AKAP2_uc004bem.2_Missense_Mutation_p.H114N|PALM2-AKAP2_uc010mtw.1_Missense_Mutation_p.H74N|AKAP2_uc011lwj.1_Missense_Mutation_p.H25N|PALM2-AKAP2_uc004ben.2_Missense_Mutation_p.H25N	NM_001136562	NP_001130034	Q9Y2D5	AKAP2_HUMAN	A kinase (PRKA) anchor protein 2 isoform 2	25							enzyme binding			ovary(3)|central_nervous_system(2)|skin(1)	6						TCCCATGGACCATCCCTCCGC	0.478			NA											37	179					1.07121e-22	2.02069e-22	0.006999	1	0
OR1L8	138881	broad.mit.edu	37	9	125330565	125330565	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr9:125330565C>A	uc004bmp.1	-	1	192	c.192G>T	c.(190-192)TTG>TTT	p.L64F		NM_001004454	NP_001004454	Q8NGR8	OR1L8_HUMAN	olfactory receptor, family 1, subfamily L,	64	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|central_nervous_system(1)	3						ACAGAAAACTCAAGAAGAAAT	0.463			NA											9	81					0.000274275	0.000316178	0.004482	1	0
SDCCAG3	10807	broad.mit.edu	37	9	139304594	139304594	+	Silent	SNP	C	C	A			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr9:139304594C>A	uc004chi.2	-	2	373	c.168G>T	c.(166-168)CCG>CCT	p.P56P	SDCCAG3_uc004chj.2_Silent_p.P56P|SDCCAG3_uc004chk.2_Intron|PMPCA_uc011mdy.1_5'Flank|PMPCA_uc010nbk.2_5'Flank|PMPCA_uc004chl.2_5'Flank|PMPCA_uc010nbl.2_5'Flank|PMPCA_uc011mdz.1_5'Flank	NM_001039707	NP_001034796	Q96C92	SDCG3_HUMAN	serologically defined colon cancer antigen 3	56						cytoplasm					0		Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;8.18e-06)|Epithelial(140;9.31e-06)		ACATAAAGGCCGGCCGAATGC	0.473			NA											6	22					0.00448238	0.00488238	0.004482	1	0
PNPLA7	375775	broad.mit.edu	37	9	140356755	140356755	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr9:140356755C>A	uc004cnf.2	-	30	3783	c.3446G>T	c.(3445-3447)CGC>CTC	p.R1149L	C9orf167_uc011mew.1_Intron|PNPLA7_uc004cnd.1_Intron|PNPLA7_uc004cne.1_Missense_Mutation_p.R415L|PNPLA7_uc011mfa.1_Missense_Mutation_p.R557L|PNPLA7_uc010ncj.1_Missense_Mutation_p.R1174L|NELF_uc004cna.2_5'Flank|NELF_uc011mez.1_5'Flank|NELF_uc004cmz.2_5'Flank|NELF_uc004cnc.2_5'Flank|NELF_uc004cnb.2_5'Flank	NM_152286	NP_689499	Q6ZV29	PLPL7_HUMAN	patatin-like phospholipase domain containing 7	1149					lipid metabolic process	endoplasmic reticulum|integral to membrane|lysosomal membrane|microsome|mitochondrial membrane|nuclear membrane	hydrolase activity			skin(1)	1	all_cancers(76;0.126)			OV - Ovarian serous cystadenocarcinoma(145;0.000268)|Epithelial(140;0.000839)		GTAGGCCAGGCGCGTCTGAAT	0.667			NA											10	82					6.40141e-05	7.74515e-05	0.000978	1	0
MXRA5	25878	broad.mit.edu	37	X	3235287	3235287	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chrX:3235287G>T	uc004crg.3	-	6	6592	c.6435C>A	c.(6433-6435)AAC>AAA	p.N2145K		NM_015419	NP_056234	Q9NR99	MXRA5_HUMAN	adlican precursor	2145						extracellular region				ovary(5)|lung(1)|central_nervous_system(1)|skin(1)	8		all_lung(23;0.00031)|Lung NSC(23;0.000946)				TGATGCGCGCGTTGGCTGCTG	0.711			NA											7	31					1.12685e-05	1.42141e-05	0.004482	1	0
MOSPD2	158747	broad.mit.edu	37	X	14934407	14934407	+	Silent	SNP	G	G	A			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chrX:14934407G>A	uc004cwi.2	+	13	1363	c.1275G>A	c.(1273-1275)CAG>CAA	p.Q425Q	MOSPD2_uc004cwj.2_Silent_p.Q362Q	NM_152581	NP_689794	Q8NHP6	MSPD2_HUMAN	motile sperm domain containing 2	425	MSP.					integral to membrane	structural molecule activity			lung(1)	1	Hepatocellular(33;0.183)					AATTAACTCAGTTTTGGAAAG	0.418			NA											38	208					0	0	0.009718	0	0
NHS	4810	broad.mit.edu	37	X	17744628	17744628	+	Missense_Mutation	SNP	T	T	C			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chrX:17744628T>C	uc004cxx.2	+	6	2677	c.2339T>C	c.(2338-2340)GTC>GCC	p.V780A	NHS_uc011mix.1_Missense_Mutation_p.V801A|NHS_uc004cxy.2_Missense_Mutation_p.V624A|NHS_uc004cxz.2_Missense_Mutation_p.V603A|NHS_uc004cya.2_Missense_Mutation_p.V503A	NM_198270	NP_938011	Q6T4R5	NHS_HUMAN	Nance-Horan syndrome protein isoform 1	780						nucleus				skin(3)|ovary(2)|breast(1)|central_nervous_system(1)	7	Hepatocellular(33;0.183)					AAGAGCTATGTCTGTCACTAT	0.512			NA											34	264					0	0	0.003755	0	0
CXorf59	286464	broad.mit.edu	37	X	36122683	36122683	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chrX:36122683C>A	uc004ddk.1	+	8	1106	c.920C>A	c.(919-921)ACA>AAA	p.T307K		NM_173695	NP_775966	Q8N9S7	CX059_HUMAN	hypothetical protein LOC286464	307						integral to membrane				central_nervous_system(1)	1						GTGCAAAATACACCAAAAGTC	0.363			NA											7	124					5.18039e-06	6.61496e-06	0.00308	1	0
CYBB	1536	broad.mit.edu	37	X	37658247	37658247	+	Silent	SNP	G	G	T			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chrX:37658247G>T	uc004ddr.2	+	7	775	c.714G>T	c.(712-714)GTG>GTT	p.V238V	CYBB_uc011mke.1_RNA|CYBB_uc011mkf.1_Silent_p.V206V|CYBB_uc011mkg.1_5'UTR	NM_000397	NP_000388	P04839	CY24B_HUMAN	cytochrome b-245 beta polypeptide	238	Extracellular (Potential).|Ferric oxidoreductase.				electron transport chain|inflammatory response|innate immune response|respiratory burst|superoxide anion generation	NADPH oxidase complex	electron carrier activity|flavin adenine dinucleotide binding|heme binding|protein heterodimerization activity|superoxide-generating NADPH oxidase activity|voltage-gated ion channel activity			central_nervous_system(1)|skin(1)	2						GTTTGGCTGTGCATAATATAA	0.368			NA											5	39					1.23904e-05	1.5488e-05	0.000602	1	0
RPGR	6103	broad.mit.edu	37	X	38132681	38132681	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chrX:38132681G>T	uc004deb.2	-	18	2367	c.2199C>A	c.(2197-2199)AAC>AAA	p.N733K	RPGR_uc004dea.2_RNA|RPGR_uc004dec.2_RNA	NM_000328	NP_000319	Q92834	RPGR_HUMAN	retinitis pigmentosa GTPase regulator isoform A	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					intracellular protein transport|response to stimulus|visual perception	Golgi apparatus|photoreceptor outer segment	guanyl-nucleotide exchange factor activity|protein binding			ovary(1)	1						TTGTTTCACTGTTTTCTAGGA	0.299			NA											5	32					8.12818e-05	9.77738e-05	0.001984	1	0
USP9X	8239	broad.mit.edu	37	X	41012324	41012324	+	Silent	SNP	A	A	G			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chrX:41012324A>G	uc004dfb.2	+	14	2520	c.1887A>G	c.(1885-1887)CTA>CTG	p.L629L	USP9X_uc004dfc.2_Silent_p.L629L	NM_001039590	NP_001034679	Q93008	USP9X_HUMAN	ubiquitin specific protease 9, X-linked isoform	629					BMP signaling pathway|cell division|chromosome segregation|female gamete generation|mitosis|protein deubiquitination|transforming growth factor beta receptor signaling pathway|ubiquitin-dependent protein catabolic process	cytoplasm	co-SMAD binding|cysteine-type endopeptidase activity|ubiquitin thiolesterase activity			lung(3)|breast(2)|ovary(1)	6						GCATGAGACTATATGCTAGAG	0.338	Ovarian(172;1807 2695 35459 49286)		NA											24	109					0	0	0.003954	0	0
ZNF674	641339	broad.mit.edu	37	X	46387869	46387869	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chrX:46387869C>A	uc004dgr.2	-	5	381	c.154G>T	c.(154-156)GGG>TGG	p.G52W	ZNF674_uc011mlg.1_Missense_Mutation_p.G52W|ZNF674_uc010nhm.2_Missense_Mutation_p.G52W	NM_001039891	NP_001034980	Q2M3X9	ZN674_HUMAN	zinc finger family member 674 isoform 1	52	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)	2						TCTGGCTTCCCAACTAGATGC	0.567			NA											17	114					4.35082e-09	6.42558e-09	0.010504	1	0
ZNF81	347344	broad.mit.edu	37	X	47774732	47774732	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chrX:47774732G>C	uc010nhy.1	+	6	1055	c.687G>C	c.(685-687)CAG>CAC	p.Q229H		NM_007137	NP_009068	P51508	ZNF81_HUMAN	zinc finger protein 81	229						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		all_lung(315;0.0973)				TTTTTACCCAGAACTCTTCTT	0.373			NA											10	111					0	0	0.008291	0	0
TIMM17B	10245	broad.mit.edu	37	X	48754088	48754088	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chrX:48754088C>A	uc004dlc.1	-	3	229	c.80G>T	c.(79-81)GGT>GTT	p.G27V	PQBP1_uc004dle.2_5'Flank|PQBP1_uc004dlf.2_5'Flank|PQBP1_uc004dlg.2_5'Flank|PQBP1_uc004dld.2_5'Flank|PQBP1_uc004dlh.2_5'Flank|PQBP1_uc004dli.2_5'Flank|PQBP1_uc004dlj.1_5'Flank|PQBP1_uc004dln.2_5'Flank|PQBP1_uc010nih.2_5'Flank|PQBP1_uc010nii.2_5'Flank|PQBP1_uc004dlk.2_5'Flank|PQBP1_uc004dll.2_5'Flank|PQBP1_uc004dlm.2_5'Flank|PQBP1_uc010nij.2_5'Flank|TIMM17B_uc004dla.1_Missense_Mutation_p.G27V|TIMM17B_uc004dlb.1_Missense_Mutation_p.V13L	NM_005834	NP_005825	O60830	TI17B_HUMAN	translocase of inner mitochondrial membrane 17	27	Helical; (Potential).				protein targeting to mitochondrion	integral to membrane|microtubule cytoskeleton|mitochondrial inner membrane presequence translocase complex	P-P-bond-hydrolysis-driven protein transmembrane transporter activity			ovary(1)	1						GACTCCGCCACCGATGACACC	0.587			NA											8	80					0.00307968	0.00337221	0.00308	1	0
DGKK	139189	broad.mit.edu	37	X	50119912	50119912	+	Silent	SNP	A	A	G			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chrX:50119912A>G	uc010njr.1	-	24	3177	c.3117T>C	c.(3115-3117)TTT>TTC	p.F1039F		NM_001013742	NP_001013764	Q5KSL6	DGKK_HUMAN	diacylglycerol kinase kappa	1039					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|diacylglycerol metabolic process|intracellular signal transduction|platelet activation|response to oxidative stress	cytoplasm|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			ovary(1)|kidney(1)	2	Ovarian(276;0.236)					TTGAGTTCTCAAAGTCCTGGA	0.478			NA											9	34					0	0	0.008291	0	0
RRAGB	10325	broad.mit.edu	37	X	55784734	55784734	+	Silent	SNP	G	G	C			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chrX:55784734G>C	uc004dup.2	+	11	1734	c.1083G>C	c.(1081-1083)CTG>CTC	p.L361L	RRAGB_uc004duq.2_Silent_p.L333L	NM_016656	NP_057740	Q5VZM2	RRAGB_HUMAN	Ras-related GTP binding B long isoform	361					cellular protein localization|cellular response to amino acid stimulus|positive regulation of TOR signaling cascade|signal transduction	Golgi apparatus|lysosome|nucleus	GTP binding|protein binding				0						TTGAAAAGCTGGAAAGAGTGG	0.423			NA											3	19					0	0	0.009096	0	0
MED12	9968	broad.mit.edu	37	X	70342990	70342990	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chrX:70342990G>T	uc004dyy.2	+	11	1730	c.1531G>T	c.(1531-1533)GCT>TCT	p.A511S	MED12_uc011mpq.1_Missense_Mutation_p.A511S|MED12_uc004dyz.2_Missense_Mutation_p.A511S|MED12_uc004dza.2_Missense_Mutation_p.A358S	NM_005120	NP_005111	Q93074	MED12_HUMAN	mediator complex subunit 12	511					androgen receptor signaling pathway|negative regulation of Wnt receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|protein C-terminus binding|protein domain specific binding|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	4	Renal(35;0.156)					ATGTGAATGGGCTGTCAGCTG	0.527			NA											39	234					1.96642e-18	3.5636e-18	0.006999	1	0
KIAA2022	340533	broad.mit.edu	37	X	73963899	73963899	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chrX:73963899G>C	uc004eby.2	-	3	1110	c.493C>G	c.(493-495)CTG>GTG	p.L165V		NM_001008537	NP_001008537	Q5QGS0	K2022_HUMAN	hypothetical protein LOC340533	165					base-excision repair, gap-filling|DNA replication proofreading|DNA replication, removal of RNA primer|nucleotide-excision repair, DNA gap filling|regulation of mitotic cell cycle|S phase of mitotic cell cycle	delta DNA polymerase complex	3'-5'-exodeoxyribonuclease activity|DNA-directed DNA polymerase activity			ovary(7)|large_intestine(4)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	15						CCAACTTTCAGACTGATCCCT	0.448			NA											10	117					0	0	0.008291	0	0
MAGEE1	57692	broad.mit.edu	37	X	75649077	75649077	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chrX:75649077C>A	uc004ecm.1	+	1	961	c.754C>A	c.(754-756)CGT>AGT	p.R252S		NM_020932	NP_065983	Q9HCI5	MAGE1_HUMAN	melanoma antigen family E, 1	252	Pro-rich.					dendrite|nucleus|perinuclear region of cytoplasm|postsynaptic membrane				breast(3)|ovary(1)|pancreas(1)|skin(1)	6						GCCACCCACCCGTGATGAGGG	0.697			NA											10	28					6.40141e-05	7.74515e-05	0.000978	1	0
MAGT1	84061	broad.mit.edu	37	X	77086363	77086363	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chrX:77086363C>A	uc004fof.2	-	9	1089	c.1027G>T	c.(1027-1029)GTA>TTA	p.V343L	MAGT1_uc004fog.3_RNA	NM_032121	NP_115497	Q9H0U3	MAGT1_HUMAN	magnesium transporter 1	311	Helical; (Potential).		V -> G (in MRX95).		protein N-linked glycosylation via asparagine	integral to membrane|oligosaccharyltransferase complex				upper_aerodigestive_tract(1)	1						AAGAATAATACAACAAGTCCA	0.323			NA											11	50					0.000151284	0.00017938	0.001855	1	0
ZCCHC5	203430	broad.mit.edu	37	X	77913592	77913592	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chrX:77913592G>A	uc004edc.1	-	2	622	c.326C>T	c.(325-327)CCA>CTA	p.P109L		NM_152694	NP_689907	Q8N8U3	ZCHC5_HUMAN	zinc finger, CCHC domain containing 5	109	Pro-rich.						nucleic acid binding|zinc ion binding			ovary(1)	1						TGGGGCTGCTGGGGCCTCCTG	0.637			NA											13	43					0	0	0.001855	0	0
CSTF2	1478	broad.mit.edu	37	X	100086550	100086550	+	Silent	SNP	T	T	A			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chrX:100086550T>A	uc004egh.2	+	9	994	c.936T>A	c.(934-936)CCT>CCA	p.P312P	CSTF2_uc010nnd.2_Silent_p.P332P|CSTF2_uc004egi.2_Silent_p.P295P	NM_001325	NP_001316	P33240	CSTF2_HUMAN	cleavage stimulation factor subunit 2	312	Gly/Pro-rich.				mRNA cleavage|mRNA polyadenylation|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	cleavage body|mRNA cleavage and polyadenylation specificity factor complex	nucleotide binding|protein binding|protein binding|RNA binding			skin(1)	1						GATCCTTGCCTGCGAATGTCC	0.527			NA											16	245					0	0	0.006122	0	0
BHLHB9	80823	broad.mit.edu	37	X	102004639	102004639	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chrX:102004639C>T	uc010nog.2	+	4	1287	c.716C>T	c.(715-717)TCT>TTT	p.S239F	BHLHB9_uc011mrq.1_Missense_Mutation_p.S239F|BHLHB9_uc011mrr.1_Missense_Mutation_p.S239F|BHLHB9_uc011mrs.1_Missense_Mutation_p.S239F|BHLHB9_uc011mrt.1_Missense_Mutation_p.S239F|BHLHB9_uc004ejo.2_Missense_Mutation_p.S239F|BHLHB9_uc011mru.1_Missense_Mutation_p.S239F|BHLHB9_uc011mrv.1_Missense_Mutation_p.S239F	NM_001142526	NP_001135998	Q6PI77	BHLH9_HUMAN	basic helix-loop-helix domain containing, class	239						cytoplasm|nucleus	binding			ovary(2)	2						CAGGCACCATCTGAGGCAAGC	0.507			NA											24	193					0	0	0.002299	0	0
ATG4A	115201	broad.mit.edu	37	X	107381398	107381398	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chrX:107381398C>A	uc004enr.2	+	9	914	c.791C>A	c.(790-792)GCG>GAG	p.A264E	ATG4A_uc004ent.2_Intron|ATG4A_uc004ens.2_Missense_Mutation_p.A180E|ATG4A_uc011msl.1_Intron|ATG4A_uc010npi.2_Intron|ATG4A_uc004enu.2_Missense_Mutation_p.A180E	NM_052936	NP_443168	Q8WYN0	ATG4A_HUMAN	autophagy-related cysteine endopeptidase 2	264					autophagy|protein transport|proteolysis	cytoplasm	cysteine-type peptidase activity			pancreas(1)	1						CCAAATAACGCGTATTATTTC	0.458			NA											47	311					8.00217e-19	1.45653e-18	0.00361	1	0
COL4A5	1287	broad.mit.edu	37	X	107821581	107821581	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chrX:107821581C>A	uc004enz.1	+	13	950	c.748C>A	c.(748-750)CCA>ACA	p.P250T	COL4A5_uc011mso.1_Missense_Mutation_p.P250T	NM_033380	NP_203699	P29400	CO4A5_HUMAN	type IV collagen alpha 5 isoform 2 precursor	250	Triple-helical region.				axon guidance	collagen type IV	extracellular matrix structural constituent|protein binding			ovary(3)|central_nervous_system(1)	4						ACAGAAAAGACCAATTGATGT	0.378			NA							Alport_syndrome_with_Diffuse_Leiomyomatosis				15	119					5.01169e-05	6.13526e-05	0.00499	1	0
GUCY2F	2986	broad.mit.edu	37	X	108708514	108708514	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chrX:108708514C>A	uc004eod.3	-	3	1165	c.889G>T	c.(889-891)GTC>TTC	p.V297F	GUCY2F_uc011msq.1_RNA	NM_001522	NP_001513	P51841	GUC2F_HUMAN	guanylate cyclase 2F precursor	297	Extracellular (Potential).				intracellular signal transduction|receptor guanylyl cyclase signaling pathway|visual perception	integral to plasma membrane|nuclear outer membrane	ATP binding|GTP binding|guanylate cyclase activity|protein kinase activity|receptor activity			lung(4)|breast(3)|central_nervous_system(1)	8						TTCCTTAGGACCCGGTAGGGG	0.478			NA											42	181					2.59497e-14	4.43174e-14	0.007835	1	0
TRPC5	7224	broad.mit.edu	37	X	111090471	111090471	+	Missense_Mutation	SNP	T	T	A	rs3027722		TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chrX:111090471T>A	uc004epl.1	-	6	2490	c.1571A>T	c.(1570-1572)TAC>TTC	p.Y524F	TRPC5_uc004epm.1_Missense_Mutation_p.Y524F	NM_012471	NP_036603	Q9UL62	TRPC5_HUMAN	transient receptor potential cation channel,	524	Helical; (Potential).				axon guidance	calcium channel complex|integral to plasma membrane	protein binding|store-operated calcium channel activity			urinary_tract(1)	1						TACCAGGCAGTAGATAAAGAG	0.463			NA											25	179					0	0	0.00278	0	0
ZCCHC16	340595	broad.mit.edu	37	X	111698312	111698312	+	Missense_Mutation	SNP	G	G	C	rs149089921		TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chrX:111698312G>C	uc004epo.1	+	3	797	c.356G>C	c.(355-357)AGT>ACT	p.S119T		NM_001004308	NP_001004308	Q6ZR62	ZCH16_HUMAN	zinc finger, CCHC domain containing 16	119							nucleic acid binding|zinc ion binding			ovary(1)	1						CCTGACAAGAGTACCTTACTG	0.383			NA											18	184					0	0	0.00499	0	0
IL13RA2	3598	broad.mit.edu	37	X	114250291	114250291	+	Missense_Mutation	SNP	T	T	A			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chrX:114250291T>A	uc004epx.2	-	3	313	c.188A>T	c.(187-189)AAG>ATG	p.K63M	IL13RA2_uc010nqd.1_Missense_Mutation_p.K63M	NM_000640	NP_000631	Q14627	I13R2_HUMAN	interleukin 13 receptor, alpha 2 precursor	63	Extracellular (Potential).|Fibronectin type-III 1.					extracellular space|integral to membrane|soluble fraction	cytokine receptor activity			upper_aerodigestive_tract(1)|ovary(1)|lung(1)	3						TGTGCATTCCTTAAAATGATC	0.408			NA											20	91					0	0	0.008871	0	0
UPF3B	65109	broad.mit.edu	37	X	118975155	118975155	+	Nonsense_Mutation	SNP	C	C	A			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chrX:118975155C>A	uc004erz.1	-	7	768	c.691G>T	c.(691-693)GAA>TAA	p.E231*	UPF3B_uc004esa.1_Nonsense_Mutation_p.E231*	NM_080632	NP_542199	Q9BZI7	REN3B_HUMAN	UPF3 regulator of nonsense transcripts homolog B	231	Sufficient for association with EJC core.|Necessary for interaction with UPF2.				mRNA 3'-end processing|mRNA export from nucleus|nuclear mRNA splicing, via spliceosome|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|positive regulation of translation|termination of RNA polymerase II transcription	cytosol|exon-exon junction complex|nucleoplasm	mRNA binding|nucleocytoplasmic transporter activity|nucleotide binding|protein binding			ovary(2)|kidney(1)	3						ctcctctcttcttctctttgt	0.144			NA											8	49					0.000274275	0.000316178	0.004482	1	0
THOC2	57187	broad.mit.edu	37	X	122765624	122765624	+	Nonsense_Mutation	SNP	G	G	T			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chrX:122765624G>T	uc004etu.2	-	22	2428	c.2396C>A	c.(2395-2397)TCA>TAA	p.S799*	THOC2_uc011muh.1_Nonsense_Mutation_p.S724*	NM_001081550	NP_001075019	Q8NI27	THOC2_HUMAN	THO complex 2	799					intronless viral mRNA export from host nucleus|mRNA processing|RNA splicing	THO complex part of transcription export complex	protein binding|RNA binding			ovary(3)	3						TACATCAATTGAAGGCACTCG	0.378			NA											28	311					3.1745e-13	5.33367e-13	0.008361	1	0
ODZ1	10178	broad.mit.edu	37	X	123515111	123515111	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chrX:123515111G>T	uc004euj.2	-	31	7517	c.7453C>A	c.(7453-7455)CAG>AAG	p.Q2485K	ODZ1_uc011muj.1_Missense_Mutation_p.Q2491K|ODZ1_uc010nqy.2_Missense_Mutation_p.Q2492K	NM_014253	NP_055068	Q9UKZ4	TEN1_HUMAN	odz, odd Oz/ten-m homolog 1 isoform 3	2485	Extracellular (Potential).				immune response|negative regulation of cell proliferation|nervous system development|signal transduction	extracellular region	heparin binding			ovary(11)|breast(4)|large_intestine(2)|skin(2)|pancreas(2)|upper_aerodigestive_tract(1)|lung(1)	23						TTCCTGAGCTGTTTCTGGAGT	0.478			NA											27	191					2.08457e-15	3.63486e-15	0.002096	1	0
DCAF12L2	340578	broad.mit.edu	37	X	125298776	125298776	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chrX:125298776G>A	uc004euk.1	-	1	1159	c.1132C>T	c.(1132-1134)CGC>TGC	p.R378C		NM_001013628	NP_001013650	Q5VW00	DC122_HUMAN	DDB1 and CUL4 associated factor 12-like 2	378	WD 4.									lung(2)|skin(2)|large_intestine(1)|pancreas(1)|ovary(1)	7						TTCTGGGCGCGGATGTCATAG	0.642			NA											18	191					0	0	0.008871	0	0
RAB33A	9363	broad.mit.edu	37	X	129318306	129318306	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chrX:129318306G>T	uc004evl.2	+	2	570	c.306G>T	c.(304-306)ATG>ATT	p.M102I	RAB33A_uc010nre.2_RNA	NM_004794	NP_004785	Q14088	RB33A_HUMAN	Ras-related protein Rab-33A	102			M -> T.		protein transport|small GTPase mediated signal transduction	plasma membrane	GTP binding|GTPase activity|protein binding				0						GCAAAAGCATGGTCGAGCATT	0.478			NA											20	122					3.08376e-08	4.32352e-08	0.00333	1	0
PHF6	84295	broad.mit.edu	37	X	133527957	133527957	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chrX:133527957C>A	uc004exj.2	+	5	595	c.393C>A	c.(391-393)CAC>CAA	p.H131Q	PHF6_uc004exk.2_Missense_Mutation_p.H131Q|PHF6_uc011mvk.1_Missense_Mutation_p.H97Q|PHF6_uc004exh.2_Missense_Mutation_p.H131Q|PHF6_uc010nrr.2_Missense_Mutation_p.H131Q|PHF6_uc004exi.2_Missense_Mutation_p.H131Q	NM_001015877	NP_001015877	Q8IWS0	PHF6_HUMAN	PHD finger protein 6 isoform 1	131	Nuclear localization signal (Potential).|PHD-type 1; degenerate.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus	zinc ion binding			ovary(1)	1	Acute lymphoblastic leukemia(192;0.000127)					GCCGAAAACACAAGAAAACTG	0.318	Colon(100;666 1493 6344 21231 35807)		NA											22	103					2.79863e-10	4.31759e-10	0.004656	1	0
PHF6	84295	broad.mit.edu	37	X	133549067	133549067	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chrX:133549067C>A	uc004exj.2	+	8	953	c.751C>A	c.(751-753)CAG>AAG	p.Q251K	PHF6_uc004exk.2_Missense_Mutation_p.Q251K|PHF6_uc011mvk.1_Missense_Mutation_p.Q217K|PHF6_uc004exh.2_Missense_Mutation_p.Q252K|PHF6_uc010nrr.2_Missense_Mutation_p.Q251K|PHF6_uc004exi.2_Missense_Mutation_p.Q252K	NM_001015877	NP_001015877	Q8IWS0	PHF6_HUMAN	PHD finger protein 6 isoform 1	251					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus	zinc ion binding			ovary(1)	1	Acute lymphoblastic leukemia(192;0.000127)					TGGCACAGTCCAGCTCACAAC	0.328	Colon(100;666 1493 6344 21231 35807)		NA											4	45					0.00024832	0.000288663	0.009096	1	0
DDX26B	203522	broad.mit.edu	37	X	134681099	134681099	+	Missense_Mutation	SNP	T	T	A			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chrX:134681099T>A	uc004eyw.3	+	6	1014	c.651T>A	c.(649-651)AAT>AAA	p.N217K		NM_182540	NP_872346	Q5JSJ4	DX26B_HUMAN	DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide	217	VWFA.										0	Acute lymphoblastic leukemia(192;6.56e-05)					GAATGTTGAATCAATGTTTAG	0.328			NA											32	190					0	0	0.002836	0	0
MAGEC1	9947	broad.mit.edu	37	X	140993253	140993253	+	Missense_Mutation	SNP	T	T	A			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chrX:140993253T>A	uc004fbt.2	+	4	349	c.63T>A	c.(61-63)AGT>AGA	p.S21R	MAGEC1_uc010nsl.1_5'UTR	NM_005462	NP_005453	O60732	MAGC1_HUMAN	melanoma antigen family C, 1	21							protein binding			ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	4	Acute lymphoblastic leukemia(192;6.56e-05)					CCTCTGAGAGTCCTCAGAGTT	0.507			NA								HNSCC(15;0.026)			20	148					0	0	0.010504	0	0
SLITRK4	139065	broad.mit.edu	37	X	142717965	142717965	+	Silent	SNP	G	G	T			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chrX:142717965G>T	uc004fbx.2	-	2	1336	c.960C>A	c.(958-960)GCC>GCA	p.A320A	SLITRK4_uc004fby.2_Silent_p.A320A	NM_173078	NP_775101	Q8IW52	SLIK4_HUMAN	slit and trk like 4 protein precursor	320	Extracellular (Potential).					integral to membrane				upper_aerodigestive_tract(1)|large_intestine(1)	2	Acute lymphoblastic leukemia(192;6.56e-05)					GGTTGGAGAGGGCTTTGCCTG	0.468			NA											34	206					8.73648e-17	1.56954e-16	0.004289	1	0
SLITRK2	84631	broad.mit.edu	37	X	144906317	144906317	+	Missense_Mutation	SNP	C	C	G	rs148553713		TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chrX:144906317C>G	uc004fcd.2	+	5	3364	c.2374C>G	c.(2374-2376)CGC>GGC	p.R792G	SLITRK2_uc010nsp.2_Missense_Mutation_p.R792G|SLITRK2_uc010nso.2_Missense_Mutation_p.R792G|SLITRK2_uc011mwq.1_Missense_Mutation_p.R792G|SLITRK2_uc011mwr.1_Missense_Mutation_p.R792G|SLITRK2_uc011mws.1_Missense_Mutation_p.R792G|SLITRK2_uc004fcg.2_Missense_Mutation_p.R792G|SLITRK2_uc011mwt.1_Missense_Mutation_p.R792G|CXorf1_uc004fch.2_5'Flank	NM_032539	NP_115928	Q9H156	SLIK2_HUMAN	SLIT and NTRK-like family, member 2 precursor	792	Cytoplasmic (Potential).					integral to membrane				ovary(5)|central_nervous_system(1)|pancreas(1)	7	Acute lymphoblastic leukemia(192;6.56e-05)					TGAATCTCGACGCCAAAACCA	0.453			NA											46	212					0	0	0.002852	0	0
MAMLD1	10046	broad.mit.edu	37	X	149638184	149638184	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chrX:149638184G>C	uc004fee.1	+	3	415	c.339G>C	c.(337-339)TTG>TTC	p.L113F	MAMLD1_uc011mxt.1_Missense_Mutation_p.L75F|MAMLD1_uc011mxu.1_Missense_Mutation_p.L88F|MAMLD1_uc011mxv.1_Missense_Mutation_p.L88F|MAMLD1_uc011mxw.1_Missense_Mutation_p.L40F	NM_005491	NP_005482	Q13495	MAMD1_HUMAN	mastermind-like domain containing 1	113					male gonad development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus					0	Acute lymphoblastic leukemia(192;6.56e-05)					TCCCTCCATTGACAATAAATC	0.493			NA											13	176					0	0	0.006122	0	0
MAMLD1	10046	broad.mit.edu	37	X	149638523	149638523	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chrX:149638523G>C	uc004fee.1	+	3	754	c.678G>C	c.(676-678)CAG>CAC	p.Q226H	MAMLD1_uc011mxt.1_Missense_Mutation_p.Q188H|MAMLD1_uc011mxu.1_Missense_Mutation_p.Q201H|MAMLD1_uc011mxv.1_Missense_Mutation_p.Q201H|MAMLD1_uc011mxw.1_Missense_Mutation_p.Q153H	NM_005491	NP_005482	Q13495	MAMD1_HUMAN	mastermind-like domain containing 1	226					male gonad development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus					0	Acute lymphoblastic leukemia(192;6.56e-05)					CTTCGGTTCAGATGTCACACT	0.517			NA											33	447					0	0	0.003271	0	0
MAMLD1	10046	broad.mit.edu	37	X	149638601	149638601	+	Silent	SNP	G	G	A			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chrX:149638601G>A	uc004fee.1	+	3	832	c.756G>A	c.(754-756)CAG>CAA	p.Q252Q	MAMLD1_uc011mxt.1_Silent_p.Q214Q|MAMLD1_uc011mxu.1_Silent_p.Q227Q|MAMLD1_uc011mxv.1_Silent_p.Q227Q|MAMLD1_uc011mxw.1_Silent_p.Q179Q	NM_005491	NP_005482	Q13495	MAMD1_HUMAN	mastermind-like domain containing 1	252					male gonad development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus					0	Acute lymphoblastic leukemia(192;6.56e-05)					TGTCACTTCAGATCCCATCCT	0.517			NA											19	312					0	0	0.003954	0	0
MAMLD1	10046	broad.mit.edu	37	X	149638622	149638622	+	Silent	SNP	G	G	A			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chrX:149638622G>A	uc004fee.1	+	3	853	c.777G>A	c.(775-777)GGG>GGA	p.G259G	MAMLD1_uc011mxt.1_Silent_p.G221G|MAMLD1_uc011mxu.1_Silent_p.G234G|MAMLD1_uc011mxv.1_Silent_p.G234G|MAMLD1_uc011mxw.1_Silent_p.G186G	NM_005491	NP_005482	Q13495	MAMD1_HUMAN	mastermind-like domain containing 1	259					male gonad development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus					0	Acute lymphoblastic leukemia(192;6.56e-05)					CCTCCACAGGGATCAGCTATT	0.527			NA											18	284					0	0	0.003954	0	0
MAMLD1	10046	broad.mit.edu	37	X	149638634	149638634	+	Silent	SNP	G	G	A	rs150886306		TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chrX:149638634G>A	uc004fee.1	+	3	865	c.789G>A	c.(787-789)TCG>TCA	p.S263S	MAMLD1_uc011mxt.1_Silent_p.S225S|MAMLD1_uc011mxu.1_Silent_p.S238S|MAMLD1_uc011mxv.1_Silent_p.S238S|MAMLD1_uc011mxw.1_Silent_p.S190S	NM_005491	NP_005482	Q13495	MAMD1_HUMAN	mastermind-like domain containing 1	263					male gonad development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus					0	Acute lymphoblastic leukemia(192;6.56e-05)					TCAGCTATTCGATTCCTTCCA	0.542			NA											19	257					0	0	0.004656	0	0
MAMLD1	10046	broad.mit.edu	37	X	149639226	149639226	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chrX:149639226G>C	uc004fee.1	+	3	1457	c.1381G>C	c.(1381-1383)GAG>CAG	p.E461Q	MAMLD1_uc011mxt.1_Missense_Mutation_p.E423Q|MAMLD1_uc011mxu.1_Missense_Mutation_p.E436Q|MAMLD1_uc011mxv.1_Missense_Mutation_p.E436Q|MAMLD1_uc011mxw.1_Missense_Mutation_p.E388Q	NM_005491	NP_005482	Q13495	MAMD1_HUMAN	mastermind-like domain containing 1	461					male gonad development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus					0	Acute lymphoblastic leukemia(192;6.56e-05)					CTATCGCCCAGAGAAGCTCTC	0.552			NA											22	225					0	0	0.00333	0	0
PASD1	139135	broad.mit.edu	37	X	150841005	150841005	+	Silent	SNP	C	C	A			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chrX:150841005C>A	uc004fev.3	+	14	2120	c.1788C>A	c.(1786-1788)CCC>CCA	p.P596P		NM_173493	NP_775764	Q8IV76	PASD1_HUMAN	PAS domain containing 1	596						nucleus	signal transducer activity			ovary(3)	3	Acute lymphoblastic leukemia(192;6.56e-05)					TATCTGTGCCCCTCTGCAATC	0.408			NA											13	121					0.00136819	0.00153046	0.001368	1	0
CNGA2	1260	broad.mit.edu	37	X	150912053	150912053	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chrX:150912053G>T	uc004fey.1	+	7	1302	c.1078G>T	c.(1078-1080)GGC>TGC	p.G360C		NM_005140	NP_005131	Q16280	CNGA2_HUMAN	cyclic nucleotide gated channel alpha 2	360	Helical; Name=H5; (Potential).				response to stimulus|sensory perception of smell	intracellular cyclic nucleotide activated cation channel complex	cAMP binding|intracellular cAMP activated cation channel activity			breast(3)	3	Acute lymphoblastic leukemia(192;6.56e-05)					CTTCCTGATTGGCGTCCTCAT	0.512			NA											18	159					6.94344e-10	1.05165e-09	0.006122	1	0
MAGEA12	4111	broad.mit.edu	37	X	151899893	151899893	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chrX:151899893G>T	uc010ntp.2	-	3	1262	c.908C>A	c.(907-909)CCC>CAC	p.P303H	MAGEA12_uc004fgb.2_Intron|MAGEA12_uc004fgc.2_Missense_Mutation_p.P303H	NM_005367	NP_005358	P43365	MAGAC_HUMAN	melanoma antigen family A, 12	303	MAGE.									skin(1)	1	Acute lymphoblastic leukemia(192;6.56e-05)					TTCATGCAGGGGTGGGTAGGA	0.567			NA											19	252					1.55795e-14	2.67168e-14	0.001882	1	0
SRPK3	26576	broad.mit.edu	37	X	153048470	153048470	+	Silent	SNP	C	C	A			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chrX:153048470C>A	uc004fil.2	+	7	677	c.645C>A	c.(643-645)CCC>CCA	p.P215P	SRPK3_uc004fik.2_Silent_p.P281P|SRPK3_uc010nul.2_Silent_p.P173P|SRPK3_uc004fin.2_Silent_p.P215P|SRPK3_uc004fim.2_Silent_p.P215P	NM_014370	NP_055185	Q9UPE1	SRPK3_HUMAN	serine arginine rich protein-specific kinase 3	215	Protein kinase.				cell differentiation|muscle organ development|muscle tissue development		ATP binding|protein serine/threonine kinase activity	p.P215H(1)		pancreas(2)|lung(1)	3	all_hematologic(71;4.25e-06)|all_lung(58;3.83e-05)|Lung NSC(58;5.54e-05)|Acute lymphoblastic leukemia(192;6.56e-05)					ACATCAAGCCCGAGAACATCT	0.652	Esophageal Squamous(167;766 3400 32156)		NA											13	112					4.3838e-07	5.84977e-07	0.001855	1	0
PDZD4	57595	broad.mit.edu	37	X	153069157	153069157	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chrX:153069157C>A	uc004fiz.1	-	8	2211	c.1961G>T	c.(1960-1962)CGG>CTG	p.R654L	PDZD4_uc004fiy.1_Missense_Mutation_p.R579L|PDZD4_uc004fix.2_Missense_Mutation_p.R558L|PDZD4_uc004fja.1_Missense_Mutation_p.R660L|PDZD4_uc011mze.1_Missense_Mutation_p.R545L	NM_032512	NP_115901	Q76G19	PDZD4_HUMAN	PDZ domain containing 4	654						cell cortex				breast(1)	1	all_lung(58;3.39e-06)|all_hematologic(71;4.25e-06)|Lung NSC(58;4.7e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					GCGCTCCTCCCGGATCTTCAG	0.652			NA											16	92					1.5739e-10	2.45552e-10	0.004007	1	0
MPP1	4354	broad.mit.edu	37	X	154007556	154007556	+	Missense_Mutation	SNP	A	A	T			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chrX:154007556A>T	uc004fmp.1	-	12	1412	c.1297T>A	c.(1297-1299)TCA>ACA	p.S433T	MPP1_uc010nvg.1_Missense_Mutation_p.S413T|MPP1_uc011mzv.1_Missense_Mutation_p.S403T|MPP1_uc004fmq.1_Missense_Mutation_p.S387T|MPP1_uc011mzw.1_Missense_Mutation_p.S416T	NM_002436	NP_002427	Q00013	EM55_HUMAN	palmitoylated membrane protein 1	433	Guanylate kinase-like.|Interaction with MPP5.				regulation of neutrophil chemotaxis|signal transduction	integral to plasma membrane|membrane fraction|stereocilium	guanylate kinase activity|protein binding			ovary(2)|central_nervous_system(1)	3	all_cancers(53;8.15e-17)|all_epithelial(53;1.1e-10)|all_lung(58;6.63e-07)|Lung NSC(58;2.08e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)					TTGACCAGTGAGAGGTCAAAG	0.507			NA											18	135					0	0	0.002299	0	0
CYP1A1	1543	broad.mit.edu	37	15	75013022	75013022	+	Frame_Shift_Del	DEL	G	G	-			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr15:75013022delG	uc002ayp.3	-	7	1469	c.1347delC	c.(1345-1347)ATCfs	p.I449fs	CYP1A1_uc010bjv.2_RNA|CYP1A1_uc010bjw.2_RNA|CYP1A1_uc010bju.2_Frame_Shift_Del_p.I185fs|CYP1A1_uc010bjx.2_Frame_Shift_Del_p.I185fs|CYP1A1_uc002ayq.3_Frame_Shift_Del_p.I449fs|CYP1A1_uc010bjy.2_Frame_Shift_Del_p.I420fs	NM_000499	NP_000490	P04798	CP1A1_HUMAN	cytochrome P450, family 1, subfamily A,	449					cellular lipid metabolic process|drug metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding|vitamin D 24-hydroxylase activity			ovary(2)|breast(2)|pancreas(1)	5					Arsenic trioxide(DB01169)|Benzphetamine(DB00865)|Bleomycin(DB00290)|Chlorzoxazone(DB00356)|Dacarbazine(DB00851)|Dactinomycin(DB00970)|Esomeprazole(DB00736)|Estrone(DB00655)|Fluvastatin(DB01095)|Fluvoxamine(DB00176)|Ginseng(DB01404)|Granisetron(DB00889)|Ketoconazole(DB01026)|Menadione(DB00170)|Picrotoxin(DB00466)|Primaquine(DB01087)|Quinidine(DB00908)|Quinine(DB00468)|Thiabendazole(DB00730)	CCATGCCAAAGATAATCACCT	0.522			NA							Endometrial_Cancer_Familial_Clustering_of|ACTH-independent_macronodular_adrenal_hyperplasia				21	238	---	---	---	---	NA	NA	NA	NA	NA
RLTPR	146206	broad.mit.edu	37	16	67683455	67683455	+	Frame_Shift_Del	DEL	G	G	-			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr16:67683455delG	uc002etn.2	+	20	1972	c.1852delG	c.(1852-1854)GGCfs	p.G618fs	RLTPR_uc010cel.1_Frame_Shift_Del_p.G611fs|RLTPR_uc010vjr.1_Frame_Shift_Del_p.G582fs	NM_001013838	NP_001013860	Q6F5E8	LR16C_HUMAN	RGD motif, leucine rich repeats, tropomodulin	618	Tropomodulin-like.|LRR 14.									breast(1)	1		Acute lymphoblastic leukemia(13;3.23e-05)|all_hematologic(13;0.00251)|Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0146)|Epithelial(162;0.0481)|all cancers(182;0.232)		GGATATCAGCGGCAACGCCAT	0.682			NA											7	77	---	---	---	---	NA	NA	NA	NA	NA
MYBPC2	4606	broad.mit.edu	37	19	50957526	50957526	+	Frame_Shift_Del	DEL	C	C	-			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr19:50957526delC	uc002psf.2	+	18	1965	c.1914delC	c.(1912-1914)GTCfs	p.V638fs		NM_004533	NP_004524	Q14324	MYPC2_HUMAN	myosin binding protein C, fast type	638	Ig-like C2-type 5.				cell adhesion|muscle filament sliding	cytosol|myosin filament	actin binding|structural constituent of muscle			breast(1)	1		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.0079)|GBM - Glioblastoma multiforme(134;0.0144)		CTGCAGATGTCCCAGACCCCC	0.642			NA											10	74	---	---	---	---	NA	NA	NA	NA	NA
SIGLEC6	946	broad.mit.edu	37	19	52023487	52023487	+	Frame_Shift_Del	DEL	G	G	-			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr19:52023487delG	uc002pwy.2	-	8	1373	c.1211delC	c.(1210-1212)ACAfs	p.T404fs	SIGLEC6_uc002pwz.2_Frame_Shift_Del_p.T388fs|SIGLEC6_uc002pxa.2_Frame_Shift_Del_p.D345fs|SIGLEC6_uc010ydb.1_Frame_Shift_Del_p.T341fs|SIGLEC6_uc010ydc.1_Frame_Shift_Del_p.Q377fs|SIGLEC6_uc010eoz.1_Frame_Shift_Del_p.D323fs	NM_001245	NP_001236	O43699	SIGL6_HUMAN	sialic acid binding Ig-like lectin 6 isoform 1	404	Cytoplasmic (Potential).				cell adhesion|cell-cell signaling	cytoplasm|extracellular region|integral to plasma membrane|membrane fraction|nucleus				ovary(1)	1		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.00115)|OV - Ovarian serous cystadenocarcinoma(262;0.0165)		AACTATGCCTGTCTGGAACTG	0.502			NA											23	320	---	---	---	---	NA	NA	NA	NA	NA
C20orf106	200232	broad.mit.edu	37	20	55100858	55100882	+	Splice_Site	DEL	AGGAGCAGAGTCCTCCTGGCCTTCG	AGGAGCAGAGTCCTCCTGGCCTTCG	-			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	AGGAGCAGAGTCCTCCTGGCCTTCG	AGGAGCAGAGTCCTCCTGGCCTTCG	-	-	AGGAGCAGAGTCCTCCTGGCCTTCG	AGGAGCAGAGTCCTCCTGGCCTTCG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr20:55100858_55100882delAGGAGCAGAGTCCTCCTGGCCTTCG	uc002xxx.2	+	2	330	c.250_splice	c.e2-1	p.E84_splice	GCNT7_uc010zzg.1_5'UTR|C20orf107_uc010zzh.1_Intron	NM_001012971	NP_001012989	Q5JX71	CT106_HUMAN	hypothetical protein LOC200232 precursor							integral to membrane					0			Colorectal(105;0.202)			CTTTCCTGACAGGAGCAGAGTCCTCCTGGCCTTCGAGGCGGCCAA	0.356			NA											19	498	---	---	---	---	NA	NA	NA	NA	NA
GALNTL2	117248	broad.mit.edu	37	3	16254176	16254176	+	Frame_Shift_Del	DEL	C	C	-			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr3:16254176delC	uc003car.3	+	6	1773	c.1298delC	c.(1297-1299)ACCfs	p.T433fs	GALNTL2_uc003caq.3_Frame_Shift_Del_p.T166fs	NM_054110	NP_473451	Q8N3T1	GLTL2_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide	433	Lumenal (Potential).					Golgi membrane|integral to membrane|transport vesicle	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			breast(1)	1						CAGGAGGCCACCCTGAGGAAC	0.552			NA											39	165	---	---	---	---	NA	NA	NA	NA	NA
UROC1	131669	broad.mit.edu	37	3	126220105	126220106	+	Frame_Shift_Ins	INS	-	-	T			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr3:126220105_126220106insT	uc003eiz.1	-	10	952_953	c.920_921insA	c.(919-921)AAGfs	p.K307fs	UROC1_uc010hsi.1_Frame_Shift_Ins_p.K367fs	NM_144639	NP_653240	Q96N76	HUTU_HUMAN	urocanase domain containing 1 isoform 1	307					histidine catabolic process	cytosol	urocanate hydratase activity			ovary(1)	1				GBM - Glioblastoma multiforme(114;0.17)		TGAGCACCTCCTTTTTTTTCCT	0.584			NA											8	375	---	---	---	---	NA	NA	NA	NA	NA
ADD1	118	broad.mit.edu	37	4	2930188	2930190	+	In_Frame_Del	DEL	AAG	AAG	-			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	AAG	AAG	-	-	AAG	AAG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr4:2930188_2930190delAAG	uc003gfr.2	+	15	2340_2342	c.2152_2154delAAG	c.(2152-2154)AAGdel	p.K721del	ADD1_uc003gfn.2_RNA|ADD1_uc003gfo.2_3'UTR|ADD1_uc003gfp.2_3'UTR|ADD1_uc003gfq.2_In_Frame_Del_p.K752del|ADD1_uc003gfs.2_3'UTR	NM_001119	NP_001110	P35611	ADDA_HUMAN	adducin 1 (alpha) isoform a	721	Interaction with calmodulin (Potential).				actin filament bundle assembly|barbed-end actin filament capping|cellular component disassembly involved in apoptosis|positive regulation of protein binding	cytosol|F-actin capping protein complex|nucleus|plasma membrane	actin filament binding|calmodulin binding|metal ion binding|protein heterodimerization activity|protein homodimerization activity|spectrin binding|transcription factor binding			ovary(1)	1				UCEC - Uterine corpus endometrioid carcinoma (64;0.168)		CCCGTCCAAAAAGAAGAAGAAGT	0.626	Esophageal Squamous(71;505 1201 20414 34538 37449)		NA											20	266	---	---	---	---	NA	NA	NA	NA	NA
RNF144B	255488	broad.mit.edu	37	6	18399839	18399839	+	Frame_Shift_Del	DEL	C	C	-			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr6:18399839delC	uc003ncs.2	+	2	378	c.74delC	c.(73-75)GCCfs	p.A25fs		NM_182757	NP_877434	Q7Z419	R144B_HUMAN	IBR domain containing 2	25					apoptosis|positive regulation of anti-apoptosis|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	integral to membrane|mitochondrial membrane	protein binding|ubiquitin-protein ligase activity|zinc ion binding				0	Ovarian(93;0.00365)|Breast(50;0.0145)	all_hematologic(90;0.0536)	OV - Ovarian serous cystadenocarcinoma(7;0.00165)|all cancers(50;0.0102)|Epithelial(50;0.0105)			CTGGCTCCGGCCCCCCTCATC	0.537			NA											18	93	---	---	---	---	NA	NA	NA	NA	NA
FAM47A	158724	broad.mit.edu	37	X	34149308	34149309	+	Frame_Shift_Ins	INS	-	-	A			TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chrX:34149308_34149309insA	uc004ddg.2	-	1	1120_1121	c.1087_1088insT	c.(1087-1089)CGCfs	p.R363fs		NM_203408	NP_981953	Q5JRC9	FA47A_HUMAN	hypothetical protein LOC158724	363										ovary(4)|central_nervous_system(1)	5						AGGCGCTAGGCGGAGACGGGAC	0.639			NA											11	84	---	---	---	---	NA	NA	NA	NA	NA
KRAS	3845	broad.mit.edu	37	12	25398285	25398285	+	Missense_Mutation	SNP	C	C	A	rs121913530		TCGA-05-4430-01A-02D-1265-08	TCGA-05-4430-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	23398531-3f4c-45e6-980b-755165c04974	00df5c73-c2a7-47b4-8007-e7042ce81305	g.chr12:25398285C>A	uc001rgp.1	-	2	215	c.34G>T	c.(34-36)GGT>TGT	p.G12C	KRAS_uc001rgq.1_Missense_Mutation_p.G12C|KRAS_uc001rgr.2_RNA	NM_033360	NP_203524	P01116	RASK_HUMAN	c-K-ras2 protein isoform a precursor	12	GTP.		G -> D (in pancreatic carcinoma, GASC and lung carcinoma; somatic mutation).|G -> R (in lung cancer and bladder cancer; somatic mutation).|G -> S (in lung carcinoma and GASC; somatic mutation).|G -> A (in a colorectal cancer sample; somatic mutation).|G -> C (in lung carcinoma; somatic mutation).|G -> V (in lung carcinoma, pancreatic carcinoma, colon cancer and GASC; somatic mutation).		activation of MAPKK activity|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	plasma membrane	GTP binding|GTPase activity|protein binding	p.G12D(7175)|p.G12V(4780)|p.G12C(2482)|p.G12A(1180)|p.G12S(1119)|p.G12R(691)|p.G12?(50)|p.G12F(34)|p.G12G(6)|p.G12N(6)|p.G12L(5)|p.G12I(4)|p.G12_G13insG(4)|p.G12E(3)|p.G12W(3)|p.A11_G12insGA(2)|p.G12Y(2)|p.G12fs*3(1)		large_intestine(12391)|pancreas(3285)|lung(2847)|biliary_tract(521)|ovary(443)|endometrium(339)|haematopoietic_and_lymphoid_tissue(318)|stomach(203)|thyroid(149)|prostate(85)|soft_tissue(77)|small_intestine(62)|upper_aerodigestive_tract(59)|cervix(49)|urinary_tract(48)|skin(38)|liver(31)|breast(28)|testis(17)|oesophagus(15)|central_nervous_system(9)|peritoneum(6)|salivary_gland(6)|kidney(5)|gastrointestinal_tract_(site_indeterminate)(5)|thymus(5)|eye(4)|autonomic_ganglia(2)|bone(2)|genital_tract(1)|penis(1)|adrenal_gland(1)	21052	all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)		OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)			CCTACGCCACCAGCTCCAACT	0.348	Pancreas(8;6 143 191 305 2070 2426 4376 10944 11745 26467 38091 50869)	G12C(UMUC3_URINARY_TRACT)|G12R(CAL62_THYROID)|G12C(CALU1_LUNG)|G12C(NCIH2030_LUNG)|G12C(LU99_LUNG)|G12C(NCIH1792_LUNG)|G12R(KP2_PANCREAS)|G12C(KHM1B_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12C(NCIH2122_LUNG)|G12C(NCIH358_LUNG)|G12R(PSN1_PANCREAS)|G12C(KYSE410_OESOPHAGUS)|G12S(A549_LUNG)|G12R(HUPT3_PANCREAS)|G12R(TCCPAN2_PANCREAS)|G12C(HCC44_LUNG)|G12S(KMS20_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12C(SW1463_LARGE_INTESTINE)|G12C(NCIH23_LUNG)|G12C(LU65_LUNG)|G12C(NCIH1373_LUNG)|G12C(MIAPACA2_PANCREAS)|G12R(HS274T_BREAST)|G12S(LS123_LARGE_INTESTINE)|G12C(SW1573_LUNG)|G12C(SW837_LARGE_INTESTINE)|G12C(OV56_OVARY)|G12C(IALM_LUNG)	119	Mis		pancreatic|colorectal|lung|thyroid|AML|others				Cardiofaciocutaneous_syndrome|Noonan_syndrome	TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)			6	16	NA	NA	NA	NA	0.0293803	0.0304821	0.001984	1	1