Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	ACHILLES_Top_Genes	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
UBE4B	10277	broad.mit.edu	37	1	10209284	10209284	+	Silent	SNP	A	A	T			TCGA-05-4403-01A-01D-1265-08	TCGA-05-4403-10A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7e25ac0e-94e4-42f6-ae6f-89d0d21ce09f	a17b5d32-f570-4d2d-9e97-f8b01de1be9f	g.chr1:10209284A>T	uc001aqs.3	+	20	3347	c.2634A>T	c.(2632-2634)GCA>GCT	p.A878A	UBE4B_uc001aqr.3_Silent_p.A749A|UBE4B_uc010oai.1_RNA|UBE4B_uc010oaj.1_Silent_p.A333A|UBE4B_uc001aqt.1_Silent_p.A218A	NM_001105562	NP_001099032	O95155	UBE4B_HUMAN	ubiquitination factor E4B isoform 1	878					apoptosis|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to UV	cytoplasm|ubiquitin ligase complex	enzyme binding			ovary(2)|skin(2)	4		all_lung(284;1.13e-05)|Lung NSC(185;1.74e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0268)|Colorectal(212;1.42e-07)|COAD - Colon adenocarcinoma(227;2.77e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000435)|Kidney(185;0.000482)|KIRC - Kidney renal clear cell carcinoma(229;0.00164)|STAD - Stomach adenocarcinoma(132;0.0117)|READ - Rectum adenocarcinoma(331;0.046)		AGGTATTTGCAGCGTTGCCTG	0.289			NA											46	201					0	0	0.00361	0	0
FAAH	2166	broad.mit.edu	37	1	46867858	46867858	+	Silent	SNP	C	C	T			TCGA-05-4403-01A-01D-1265-08	TCGA-05-4403-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7e25ac0e-94e4-42f6-ae6f-89d0d21ce09f	a17b5d32-f570-4d2d-9e97-f8b01de1be9f	g.chr1:46867858C>T	uc001cpu.2	+	2	373	c.291C>T	c.(289-291)CTC>CTT	p.L97L		NM_001441	NP_001432	O00519	FAAH1_HUMAN	fatty acid amide hydrolase	97	Cytoplasmic (By similarity).				fatty acid catabolic process	cytoplasm|cytoskeleton|endomembrane system|integral to membrane|organelle membrane	carbon-nitrogen ligase activity, with glutamine as amido-N-donor|fatty acid amide hydrolase activity			ovary(1)|breast(1)	2	Acute lymphoblastic leukemia(166;0.155)				Propofol(DB00818)|Thiopental(DB00599)	AGGCCGTGCTCTTCACCTATG	0.632			NA											5	15					0	0	0.001168	0	0
PTBP2	58155	broad.mit.edu	37	1	97278882	97278882	+	Missense_Mutation	SNP	A	A	C			TCGA-05-4403-01A-01D-1265-08	TCGA-05-4403-10A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7e25ac0e-94e4-42f6-ae6f-89d0d21ce09f	a17b5d32-f570-4d2d-9e97-f8b01de1be9f	g.chr1:97278882A>C	uc001drq.2	+	14	1763	c.1517A>C	c.(1516-1518)CAG>CCG	p.Q506P	PTBP2_uc001drn.2_Missense_Mutation_p.Q512P|PTBP2_uc001dro.2_Missense_Mutation_p.Q507P|PTBP2_uc010otz.1_Missense_Mutation_p.Q523P|PTBP2_uc001drp.2_RNA|PTBP2_uc009wdw.2_Missense_Mutation_p.Q455P|PTBP2_uc001drr.2_Missense_Mutation_p.Q511P|PTBP2_uc010oua.1_Missense_Mutation_p.Q515P|PTBP2_uc001dru.2_RNA|PTBP2_uc001drs.1_Missense_Mutation_p.Q126P|PTBP2_uc001drt.2_Missense_Mutation_p.Q125P	NM_021190	NP_067013	Q9UKA9	PTBP2_HUMAN	polypyrimidine tract binding protein 2	506	RRM 4.						nucleotide binding				0		all_epithelial(167;2.95e-05)|all_lung(203;0.000396)|Lung NSC(277;0.00171)		all cancers(265;0.0582)|Epithelial(280;0.0716)|Colorectal(170;0.0879)|KIRC - Kidney renal clear cell carcinoma(1967;0.202)		GAAGCTATTCAGGCCTTGATT	0.348			NA											19	50					0	0	0.010504	0	0
VCAM1	7412	broad.mit.edu	37	1	101196962	101196962	+	Silent	SNP	C	C	A			TCGA-05-4403-01A-01D-1265-08	TCGA-05-4403-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7e25ac0e-94e4-42f6-ae6f-89d0d21ce09f	a17b5d32-f570-4d2d-9e97-f8b01de1be9f	g.chr1:101196962C>A	uc001dti.2	+	6	1533	c.1413C>A	c.(1411-1413)ATC>ATA	p.I471I	VCAM1_uc001dtj.2_Silent_p.I379I|VCAM1_uc010ouj.1_Silent_p.I409I	NM_001078	NP_001069	P19320	VCAM1_HUMAN	vascular cell adhesion molecule 1 isoform a	471	Ig-like C2-type 5.|Extracellular (Potential).				heterophilic cell-cell adhesion|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|leukocyte tethering or rolling|membrane to membrane docking|positive regulation of T cell proliferation|regulation of immune response	alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex|apical part of cell|external side of plasma membrane|extracellular space|filopodium|integral to membrane|microvillus|podosome	cell adhesion molecule binding|integrin binding			central_nervous_system(1)	1		all_epithelial(167;3.83e-06)|all_lung(203;0.000485)|Lung NSC(277;0.0011)		Epithelial(280;0.0227)|all cancers(265;0.0276)|COAD - Colon adenocarcinoma(174;0.149)|Colorectal(144;0.169)|Lung(183;0.196)	Carvedilol(DB01136)	TGACCTTCATCCCTACCATTG	0.383			NA											20	86					2.4624e-09	2.90364e-09	0.008871	1	0
NOTCH2	4853	broad.mit.edu	37	1	120539844	120539844	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4403-01A-01D-1265-08	TCGA-05-4403-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7e25ac0e-94e4-42f6-ae6f-89d0d21ce09f	a17b5d32-f570-4d2d-9e97-f8b01de1be9f	g.chr1:120539844C>A	uc001eik.2	-	4	783	c.527G>T	c.(526-528)GGG>GTG	p.G176V	NOTCH2_uc001eil.2_Missense_Mutation_p.G176V|NOTCH2_uc001eim.3_Missense_Mutation_p.G93V	NM_024408	NP_077719	Q04721	NOTC2_HUMAN	notch 2 preproprotein	176	Extracellular (Potential).|EGF-like 4.				anti-apoptosis|bone remodeling|cell cycle arrest|cell fate determination|cell growth|hemopoiesis|induction of apoptosis|negative regulation of cell proliferation|nervous system development|Notch receptor processing|Notch signaling pathway|organ morphogenesis|positive regulation of Ras protein signal transduction|regulation of transcription, DNA-dependent|stem cell maintenance|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|ligand-regulated transcription factor activity|protein binding|receptor activity			lung(8)|haematopoietic_and_lymphoid_tissue(7)|ovary(4)|central_nervous_system(2)|skin(2)|kidney(2)|breast(1)|prostate(1)	27	all_neural(166;0.153)	all_lung(203;1.96e-06)|Lung NSC(69;1.47e-05)|all_epithelial(167;0.000809)		Lung(183;0.0242)|LUSC - Lung squamous cell carcinoma(189;0.133)		ACATTTCTGCCCTGTGAAGCC	0.547			NA	N|F|Mis		marginal zone lymphoma|DLBCL				Alagille_Syndrome				30	126					3.90053e-15	4.97317e-15	0.012213	1	0
FLG	2312	broad.mit.edu	37	1	152279982	152279982	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4403-01A-01D-1265-08	TCGA-05-4403-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7e25ac0e-94e4-42f6-ae6f-89d0d21ce09f	a17b5d32-f570-4d2d-9e97-f8b01de1be9f	g.chr1:152279982G>T	uc001ezu.1	-	3	7416	c.7380C>A	c.(7378-7380)GAC>GAA	p.D2460E		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	2460	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CATGAATGGTGTCCTGACCCT	0.587			NA							Ichthyosis				129	580					2.3678e-45	3.42575e-45	0.00361	1	0
FLG	2312	broad.mit.edu	37	1	152281324	152281324	+	Nonsense_Mutation	SNP	G	G	C			TCGA-05-4403-01A-01D-1265-08	TCGA-05-4403-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7e25ac0e-94e4-42f6-ae6f-89d0d21ce09f	a17b5d32-f570-4d2d-9e97-f8b01de1be9f	g.chr1:152281324G>C	uc001ezu.1	-	3	6074	c.6038C>G	c.(6037-6039)TCA>TGA	p.S2013*		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	2013	Ser-rich.|Filaggrin 12.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GCTGTCTGCTGACTGGAGCTG	0.557			NA							Ichthyosis				182	705					0	0	0.00361	0	0
CDC73	79577	broad.mit.edu	37	1	193099332	193099332	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4403-01A-01D-1265-08	TCGA-05-4403-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7e25ac0e-94e4-42f6-ae6f-89d0d21ce09f	a17b5d32-f570-4d2d-9e97-f8b01de1be9f	g.chr1:193099332C>G	uc001gtb.2	+	3	509	c.266C>G	c.(265-267)CCT>CGT	p.P89R		NM_024529	NP_078805	Q6P1J9	CDC73_HUMAN	parafibromin	89					cell cycle|histone H2B ubiquitination|histone monoubiquitination|transcription, DNA-dependent	Cdc73/Paf1 complex	protein binding			parathyroid(46)|ovary(1)|breast(1)|pancreas(1)	49						GTTAGAAGACCTGATCGAAAA	0.259			NA							Hyperparathyroidism_Familial_Isolated|Hyperparathyroidism-Jaw_Tumor_Syndrome				13	40					0	0	0.00245	0	0
ESRRG	2104	broad.mit.edu	37	1	216737685	216737685	+	Silent	SNP	C	C	T			TCGA-05-4403-01A-01D-1265-08	TCGA-05-4403-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7e25ac0e-94e4-42f6-ae6f-89d0d21ce09f	a17b5d32-f570-4d2d-9e97-f8b01de1be9f	g.chr1:216737685C>T	uc001hkw.1	-	5	904	c.738G>A	c.(736-738)CCG>CCA	p.P246P	ESRRG_uc001hky.1_Silent_p.P223P|ESRRG_uc009xdp.1_Silent_p.P223P|ESRRG_uc001hkz.1_Silent_p.P184P|ESRRG_uc010puc.1_Silent_p.P223P|ESRRG_uc001hla.1_Silent_p.P223P|ESRRG_uc001hlb.1_Silent_p.P223P|ESRRG_uc010pud.1_Silent_p.P54P|ESRRG_uc001hlc.1_Silent_p.P223P|ESRRG_uc001hld.1_Silent_p.P223P|ESRRG_uc001hkx.1_Silent_p.P258P|ESRRG_uc009xdo.1_Silent_p.P223P|ESRRG_uc001hle.1_Silent_p.P223P	NM_001438	NP_001429	P62508	ERR3_HUMAN	estrogen-related receptor gamma isoform 1	246					positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	AF-2 domain binding|retinoic acid receptor activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			ovary(1)|kidney(1)	2				OV - Ovarian serous cystadenocarcinoma(81;0.0358)|all cancers(67;0.0693)|GBM - Glioblastoma multiforme(131;0.0713)	Diethylstilbestrol(DB00255)	AGATCTTCTCCGGTTCAGCCA	0.478			NA											15	51					0	0	0.003163	0	0
NVL	4931	broad.mit.edu	37	1	224424241	224424241	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4403-01A-01D-1265-08	TCGA-05-4403-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7e25ac0e-94e4-42f6-ae6f-89d0d21ce09f	a17b5d32-f570-4d2d-9e97-f8b01de1be9f	g.chr1:224424241G>A	uc001hok.2	-	20	2376	c.2333C>T	c.(2332-2334)GCA>GTA	p.A778V	NVL_uc001hol.2_Missense_Mutation_p.A672V|NVL_uc010pvd.1_Missense_Mutation_p.A687V|NVL_uc010pve.1_Missense_Mutation_p.A589V|NVL_uc010pvf.1_RNA	NM_002533	NP_002524	O15381	NVL_HUMAN	nuclear VCP-like isoform 1	778						aggresome|cytoplasm|nucleolus	ATP binding|nucleoside-triphosphatase activity			skin(2)	2				GBM - Glioblastoma multiforme(131;0.00501)		ACCAGCAATTGCTTCCAAATT	0.259			NA											33	155					0	0	0.005524	0	0
MTR	4548	broad.mit.edu	37	1	237052596	237052596	+	Silent	SNP	G	G	C			TCGA-05-4403-01A-01D-1265-08	TCGA-05-4403-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7e25ac0e-94e4-42f6-ae6f-89d0d21ce09f	a17b5d32-f570-4d2d-9e97-f8b01de1be9f	g.chr1:237052596G>C	uc001hyi.3	+	28	3390	c.2967G>C	c.(2965-2967)CCG>CCC	p.P989P	MTR_uc010pxw.1_Silent_p.P582P|MTR_uc010pxx.1_Silent_p.P938P|MTR_uc010pxy.1_Silent_p.P843P	NM_000254	NP_000245	Q99707	METH_HUMAN	5-methyltetrahydrofolate-homocysteine	989	AdoMet activation.				nervous system development|xenobiotic metabolic process	cytosol	cobalamin binding|homocysteine S-methyltransferase activity|methionine synthase activity|protein binding|zinc ion binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3	Ovarian(103;0.0634)|Breast(184;0.221)	all_cancers(173;2.79e-22)|all_epithelial(177;4.84e-14)|Breast(1374;0.00123)|Prostate(94;0.0181)|Lung SC(1967;0.0262)|Acute lymphoblastic leukemia(190;0.117)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)	KIRC - Kidney renal clear cell carcinoma(1967;0.248)	Hydroxocobalamin(DB00200)|L-Methionine(DB00134)|Tetrahydrofolic acid(DB00116)	GCAAGTACCCGAATCGAGGCT	0.473			NA											22	102					0	0	0.012319	0	0
NLRP3	114548	broad.mit.edu	37	1	247587992	247587992	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4403-01A-01D-1265-08	TCGA-05-4403-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7e25ac0e-94e4-42f6-ae6f-89d0d21ce09f	a17b5d32-f570-4d2d-9e97-f8b01de1be9f	g.chr1:247587992G>C	uc001icr.2	+	5	1385	c.1247G>C	c.(1246-1248)TGG>TCG	p.W416S	NLRP3_uc001ics.2_Missense_Mutation_p.W416S|NLRP3_uc001icu.2_Missense_Mutation_p.W416S|NLRP3_uc001icw.2_Missense_Mutation_p.W416S|NLRP3_uc001icv.2_Missense_Mutation_p.W416S|NLRP3_uc010pyw.1_Missense_Mutation_p.W414S|NLRP3_uc001ict.1_Missense_Mutation_p.W414S	NM_001079821	NP_001073289	Q96P20	NALP3_HUMAN	NLR family, pyrin domain containing 3 isoform a	416	NACHT.				detection of biotic stimulus|induction of apoptosis|inflammatory response|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|positive regulation of interleukin-1 beta secretion|protein oligomerization|signal transduction	cytoplasm	ATP binding|peptidoglycan binding|protein binding			lung(8)|skin(8)|ovary(7)|upper_aerodigestive_tract(1)|breast(1)|pancreas(1)	26	all_cancers(71;9.66e-05)|all_epithelial(71;1.85e-05)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.0172)	OV - Ovarian serous cystadenocarcinoma(106;0.0141)			CTGGTCTGCTGGATCGTGTGC	0.547			NA											18	102					0	0	0.007413	0	0
OR2M2	391194	broad.mit.edu	37	1	248343317	248343317	+	Silent	SNP	C	C	A			TCGA-05-4403-01A-01D-1265-08	TCGA-05-4403-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7e25ac0e-94e4-42f6-ae6f-89d0d21ce09f	a17b5d32-f570-4d2d-9e97-f8b01de1be9f	g.chr1:248343317C>A	uc010pzf.1	+	1	30	c.30C>A	c.(28-30)TCC>TCA	p.S10S		NM_001004688	NP_001004688	Q96R28	OR2M2_HUMAN	olfactory receptor, family 2, subfamily M,	10	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(3)|skin(1)	4	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			CCTTCAACTCCGACTTCATCC	0.433			NA											29	138					2.85442e-18	3.7327e-18	0.010818	1	0
MAPK8	5599	broad.mit.edu	37	10	49634457	49634457	+	Silent	SNP	G	G	T			TCGA-05-4403-01A-01D-1265-08	TCGA-05-4403-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7e25ac0e-94e4-42f6-ae6f-89d0d21ce09f	a17b5d32-f570-4d2d-9e97-f8b01de1be9f	g.chr10:49634457G>T	uc009xnz.2	+	9	1130	c.906G>T	c.(904-906)CTG>CTT	p.L302L	MAPK8_uc001jgl.2_Silent_p.L302L|MAPK8_uc001jgm.2_Silent_p.L302L|MAPK8_uc001jgo.2_Silent_p.L302L|MAPK8_uc009xoa.2_Silent_p.L226L|MAPK8_uc001jgn.2_Silent_p.L302L|MAPK8_uc010qgk.1_Silent_p.L302L|MAPK8_uc001jgp.2_Silent_p.L302L|MAPK8_uc001jgq.2_Silent_p.L302L	NM_139047	NP_620635	P45983	MK08_HUMAN	mitogen-activated protein kinase 8 isoform JNK1	302	Protein kinase.				activation of pro-apoptotic gene products|cellular response to mechanical stimulus|induction of apoptosis by intracellular signals|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of apoptosis|negative regulation of protein binding|nerve growth factor receptor signaling pathway|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of deacetylase activity|regulation of protein localization|regulation of sequence-specific DNA binding transcription factor activity|response to UV|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|histone deacetylase binding|histone deacetylase regulator activity|JUN kinase activity|protein binding			central_nervous_system(3)|lung(2)|stomach(1)|ovary(1)|kidney(1)	8		Ovarian(717;0.0221)|Lung SC(717;0.113)|all_neural(218;0.116)		Epithelial(53;3.46e-65)|Lung(62;0.125)		CCAAAATGCTGGTAATAGATG	0.358			NA											14	41					0.000422831	0.000444627	0.004007	1	0
GLUD1	2746	broad.mit.edu	37	10	88819956	88819956	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4403-01A-01D-1265-08	TCGA-05-4403-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7e25ac0e-94e4-42f6-ae6f-89d0d21ce09f	a17b5d32-f570-4d2d-9e97-f8b01de1be9f	g.chr10:88819956C>G	uc001keh.2	-	9	1337	c.1240G>C	c.(1240-1242)GAC>CAC	p.D414H	GLUD1_uc001keg.2_Missense_Mutation_p.D247H|GLUD1_uc010qmp.1_Missense_Mutation_p.D281H	NM_005271	NP_005262	P00367	DHE3_HUMAN	glutamate dehydrogenase 1 precursor	414					glutamate biosynthetic process|glutamate catabolic process|positive regulation of insulin secretion	mitochondrial matrix	ADP binding|ATP binding|glutamate dehydrogenase|glutamate dehydrogenase activity|GTP binding|identical protein binding|leucine binding|NAD+ binding				0					L-Glutamic Acid(DB00142)|NADH(DB00157)	AAGATCTTGTCAGCTTCTGGA	0.408			NA											19	114					0	0	0.012319	0	0
PDCD11	22984	broad.mit.edu	37	10	105169541	105169541	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4403-01A-01D-1265-08	TCGA-05-4403-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7e25ac0e-94e4-42f6-ae6f-89d0d21ce09f	a17b5d32-f570-4d2d-9e97-f8b01de1be9f	g.chr10:105169541G>T	uc001kwy.1	+	8	1043	c.956G>T	c.(955-957)GGA>GTA	p.G319V		NM_014976	NP_055791	Q14690	RRP5_HUMAN	programmed cell death 11	319	S1 motif 3.				mRNA processing|rRNA processing	nucleolus	RNA binding|transcription factor binding			ovary(2)|breast(2)|skin(2)|central_nervous_system(1)	7		Colorectal(252;0.0747)|Breast(234;0.128)		Epithelial(162;7.21e-09)|all cancers(201;1.17e-08)|BRCA - Breast invasive adenocarcinoma(275;0.208)		AAGAAAGCTGGAACATATTTC	0.433			NA											29	118					6.70999e-13	8.34657e-13	0.004289	1	0
MICAL2	9645	broad.mit.edu	37	11	12281439	12281439	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4403-01A-01D-1265-08	TCGA-05-4403-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7e25ac0e-94e4-42f6-ae6f-89d0d21ce09f	a17b5d32-f570-4d2d-9e97-f8b01de1be9f	g.chr11:12281439C>T	uc001mjz.2	+	26	3617	c.3329C>T	c.(3328-3330)CCC>CTC	p.P1110L	MICAL2_uc010rch.1_Missense_Mutation_p.P920L|MICAL2_uc001mka.2_Missense_Mutation_p.P1110L|MICAL2_uc010rci.1_Missense_Mutation_p.P1089L|MICAL2_uc001mkb.2_Missense_Mutation_p.P884L|MICAL2_uc001mkc.2_Missense_Mutation_p.P863L|MICAL2_uc001mkd.2_Missense_Mutation_p.P692L|MICAL2_uc010rcj.1_Missense_Mutation_p.P322L|MICAL2_uc001mkf.2_RNA	NM_014632	NP_055447	O94851	MICA2_HUMAN	microtubule associated monoxygenase, calponin	1110						cytoplasm|cytoskeleton	monooxygenase activity|zinc ion binding			upper_aerodigestive_tract(2)	2				Epithelial(150;0.00552)		GAAGGCAGCCCCCCAGGTATC	0.622			NA											5	37					0	0	0.006214	0	0
SPTY2D1	144108	broad.mit.edu	37	11	18637496	18637496	+	Nonsense_Mutation	SNP	G	G	A			TCGA-05-4403-01A-01D-1265-08	TCGA-05-4403-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7e25ac0e-94e4-42f6-ae6f-89d0d21ce09f	a17b5d32-f570-4d2d-9e97-f8b01de1be9f	g.chr11:18637496G>A	uc001moy.2	-	3	541	c.325C>T	c.(325-327)CAG>TAG	p.Q109*	SPTY2D1_uc010rdi.1_Nonsense_Mutation_p.Q109*	NM_194285	NP_919261	Q68D10	SPT2_HUMAN	SPT2, Suppressor of Ty, domain containing 1	109										breast(1)	1						TCTGTTGCCTGCCTCTTCTTT	0.448			NA											34	144					0	0	0.004878	0	0
SLC17A6	57084	broad.mit.edu	37	11	22363306	22363306	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4403-01A-01D-1265-08	TCGA-05-4403-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7e25ac0e-94e4-42f6-ae6f-89d0d21ce09f	a17b5d32-f570-4d2d-9e97-f8b01de1be9f	g.chr11:22363306G>T	uc001mqk.2	+	2	732	c.319G>T	c.(319-321)GGG>TGG	p.G107W		NM_020346	NP_065079	Q9P2U8	VGLU2_HUMAN	solute carrier family 17 (sodium-dependent	107	Vesicular (Potential).				sodium ion transport	cell junction|integral to membrane|synaptic vesicle membrane|synaptosome	L-glutamate transmembrane transporter activity|symporter activity			ovary(3)|breast(1)	4						CATCCACCGCGGGGGCAAGGT	0.632			NA											21	83					3.73808e-20	4.95175e-20	0.005443	1	0
BBOX1	8424	broad.mit.edu	37	11	27148881	27148881	+	Silent	SNP	C	C	A			TCGA-05-4403-01A-01D-1265-08	TCGA-05-4403-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7e25ac0e-94e4-42f6-ae6f-89d0d21ce09f	a17b5d32-f570-4d2d-9e97-f8b01de1be9f	g.chr11:27148881C>A	uc001mre.1	+	9	1413	c.1045C>A	c.(1045-1047)CGA>AGA	p.R349R	BBOX1_uc009yih.1_Silent_p.R349R|BBOX1_uc001mrg.1_Silent_p.R349R	NM_003986	NP_003977	O75936	BODG_HUMAN	gamma-butyrobetaine dioxygenase	349					carnitine biosynthetic process	actin cytoskeleton|cytosol|intracellular membrane-bounded organelle	gamma-butyrobetaine dioxygenase activity|iron ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|zinc ion binding			ovary(1)	1					Succinic acid(DB00139)|Vitamin C(DB00126)	ACTTCATGGCCGACGTAGCTA	0.408			NA											14	89					1.15088e-07	1.32644e-07	0.004007	1	0
TNKS1BP1	85456	broad.mit.edu	37	11	57087739	57087739	+	Missense_Mutation	SNP	C	C	A	rs142187077	byFrequency	TCGA-05-4403-01A-01D-1265-08	TCGA-05-4403-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7e25ac0e-94e4-42f6-ae6f-89d0d21ce09f	a17b5d32-f570-4d2d-9e97-f8b01de1be9f	g.chr11:57087739C>A	uc001njr.2	-	2	854	c.542G>T	c.(541-543)CGC>CTC	p.R181L	TNKS1BP1_uc001njs.2_Missense_Mutation_p.R181L|TNKS1BP1_uc009ymd.1_5'UTR	NM_033396	NP_203754	Q9C0C2	TB182_HUMAN	tankyrase 1-binding protein 1	181	Pro-rich.				nuclear-transcribed mRNA poly(A) tail shortening|telomere maintenance via telomerase	cytoskeleton|cytosol|nuclear telomeric heterochromatin	ankyrin binding|enzyme binding			skin(1)	1		all_epithelial(135;0.21)				ACCCCACAGGCGGTCGGGGCT	0.652			NA											21	83					4.40665e-25	6.19969e-25	0.009535	1	0
UBE2L6	9246	broad.mit.edu	37	11	57319895	57319895	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4403-01A-01D-1265-08	TCGA-05-4403-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7e25ac0e-94e4-42f6-ae6f-89d0d21ce09f	a17b5d32-f570-4d2d-9e97-f8b01de1be9f	g.chr11:57319895G>A	uc001nkn.1	-	4	494	c.398C>T	c.(397-399)CCG>CTG	p.P133L	UBE2L6_uc001nko.1_Missense_Mutation_p.P67L	NM_004223	NP_004214	O14933	UB2L6_HUMAN	ubiquitin-conjugating enzyme E2L 6 isoform 1	133					negative regulation of type I interferon production	cytosol	protein binding|ubiquitin-protein ligase activity			ovary(1)	1						GAACAGCTCCGGATTCTGTGT	0.577			NA											73	272					0	0	0.00361	0	0
EHBP1L1	254102	broad.mit.edu	37	11	65351973	65351973	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4403-01A-01D-1265-08	TCGA-05-4403-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7e25ac0e-94e4-42f6-ae6f-89d0d21ce09f	a17b5d32-f570-4d2d-9e97-f8b01de1be9f	g.chr11:65351973G>A	uc001oeo.3	+	11	3533	c.3268G>A	c.(3268-3270)GAC>AAC	p.D1090N	EHBP1L1_uc001oep.1_Missense_Mutation_p.D110N	NM_001099409	NP_001092879	Q8N3D4	EH1L1_HUMAN	tangerin	1090	CH.									central_nervous_system(1)	1						TGCCTCGCTAGACCCACTCAA	0.597			NA											11	23					0	0	0.001368	0	0
DNAJB13	374407	broad.mit.edu	37	11	73662017	73662017	+	Translation_Start_Site	SNP	G	G	A			TCGA-05-4403-01A-01D-1265-08	TCGA-05-4403-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7e25ac0e-94e4-42f6-ae6f-89d0d21ce09f	a17b5d32-f570-4d2d-9e97-f8b01de1be9f	g.chr11:73662017G>A	uc001ouo.2	+	1	654	c.-97G>A	c.(-99--95)GAGTG>GAATG			NM_153614	NP_705842	P59910	DJB13_HUMAN	testis spermatogenesis apoptosis-related protein						apoptosis|protein folding|spermatogenesis		heat shock protein binding|unfolded protein binding				0	Breast(11;7.42e-05)					AACTCCCAGAGTGCACCTGTG	0.557			NA											3	10					0	0	0.004672	0	0
PPME1	51400	broad.mit.edu	37	11	73950294	73950294	+	Missense_Mutation	SNP	A	A	G			TCGA-05-4403-01A-01D-1265-08	TCGA-05-4403-10A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7e25ac0e-94e4-42f6-ae6f-89d0d21ce09f	a17b5d32-f570-4d2d-9e97-f8b01de1be9f	g.chr11:73950294A>G	uc001ouw.2	+	9	926	c.827A>G	c.(826-828)GAC>GGC	p.D276G	PPME1_uc009yty.2_Missense_Mutation_p.D146G|PPME1_uc001oux.2_Missense_Mutation_p.D89G	NM_016147	NP_057231	Q9Y570	PPME1_HUMAN	protein phosphatase methylesterase 1	276					protein demethylation		carboxylesterase activity|protein C-terminal methylesterase activity|protein phosphatase 2A binding|protein phosphatase inhibitor activity|protein phosphatase type 2A regulator activity				0	Breast(11;3.29e-05)					AAGGAAGATGACATGGAGGTG	0.403			NA											10	41					0	0	0.008291	0	0
RSF1	51773	broad.mit.edu	37	11	77412022	77412022	+	Missense_Mutation	SNP	T	T	A			TCGA-05-4403-01A-01D-1265-08	TCGA-05-4403-10A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7e25ac0e-94e4-42f6-ae6f-89d0d21ce09f	a17b5d32-f570-4d2d-9e97-f8b01de1be9f	g.chr11:77412022T>A	uc001oyn.2	-	6	2372	c.2252A>T	c.(2251-2253)AAA>ATA	p.K751I	RSF1_uc001oym.2_Missense_Mutation_p.K499I	NM_016578	NP_057662	Q96T23	RSF1_HUMAN	remodeling and spacing factor 1	751					CenH3-containing nucleosome assembly at centromere|negative regulation of DNA binding|negative regulation of transcription, DNA-dependent|nucleosome positioning|positive regulation of transcription, DNA-dependent|positive regulation of viral transcription|transcription initiation, DNA-dependent	RSF complex	histone binding|protein binding|zinc ion binding			ovary(2)|central_nervous_system(2)	4	all_cancers(14;1.54e-17)|all_epithelial(13;4.06e-20)|Ovarian(111;0.152)		Epithelial(5;3e-50)|all cancers(3;6.37e-47)|BRCA - Breast invasive adenocarcinoma(5;9.82e-31)			TTCTAGAACTTTGGGGGGAGA	0.413			NA											73	229					0	0	0.00361	0	0
CNTN5	53942	broad.mit.edu	37	11	99715850	99715850	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4403-01A-01D-1265-08	TCGA-05-4403-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7e25ac0e-94e4-42f6-ae6f-89d0d21ce09f	a17b5d32-f570-4d2d-9e97-f8b01de1be9f	g.chr11:99715850G>A	uc001pga.2	+	6	772	c.433G>A	c.(433-435)GAA>AAA	p.E145K	CNTN5_uc009ywv.1_Missense_Mutation_p.E145K|CNTN5_uc001pfz.2_Missense_Mutation_p.E145K|CNTN5_uc001pgb.2_Missense_Mutation_p.E71K	NM_014361	NP_055176	O94779	CNTN5_HUMAN	contactin 5 isoform long	145	Ig-like C2-type 1.				cell adhesion	anchored to membrane|plasma membrane	protein binding			skin(3)|ovary(2)|pancreas(2)|breast(1)	8		all_hematologic(158;1.22e-05)|Acute lymphoblastic leukemia(157;3.81e-05)|Melanoma(852;0.219)		BRCA - Breast invasive adenocarcinoma(274;0.00146)|KIRC - Kidney renal clear cell carcinoma(183;0.156)|Kidney(183;0.196)		AATAGATCTGGAAAGTGATTA	0.368			NA											22	81					0	0	0.012319	0	0
PVRL1	5818	broad.mit.edu	37	11	119547916	119547916	+	Silent	SNP	T	T	C			TCGA-05-4403-01A-01D-1265-08	TCGA-05-4403-10A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7e25ac0e-94e4-42f6-ae6f-89d0d21ce09f	a17b5d32-f570-4d2d-9e97-f8b01de1be9f	g.chr11:119547916T>C	uc001pwv.2	-	4	919	c.747A>G	c.(745-747)GTA>GTG	p.V249V	PVRL1_uc001pwu.1_Silent_p.V249V|PVRL1_uc001pww.2_Silent_p.V249V	NM_002855	NP_002846	Q15223	PVRL1_HUMAN	poliovirus receptor-related 1 isoform 1	249	Extracellular (Potential).|Ig-like C2-type 2.				adherens junction organization|cell junction assembly|entry of virus into host cell|heterophilic cell-cell adhesion|homophilic cell adhesion|immune response	cell-cell adherens junction|extracellular region|integral to membrane	cell adhesion molecule binding|coreceptor activity|protein homodimerization activity				0		Breast(348;0.037)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;4.29e-05)		CCTCAATGGTTACCTCAGGCT	0.552			NA											22	105					0	0	0.00333	0	0
NCAPD3	23310	broad.mit.edu	37	11	134062761	134062761	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4403-01A-01D-1265-08	TCGA-05-4403-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7e25ac0e-94e4-42f6-ae6f-89d0d21ce09f	a17b5d32-f570-4d2d-9e97-f8b01de1be9f	g.chr11:134062761C>A	uc001qhd.1	-	16	2474	c.1868G>T	c.(1867-1869)GGG>GTG	p.G623V	NCAPD3_uc010scm.1_RNA|NCAPD3_uc009zda.1_RNA	NM_015261	NP_056076	P42695	CNDD3_HUMAN	non-SMC condensin II complex, subunit D3	623					cell division|mitotic chromosome condensation	nuclear centromeric heterochromatin|nuclear condensin complex	methylated histone residue binding			ovary(2)|upper_aerodigestive_tract(1)|lung(1)|kidney(1)	5	all_hematologic(175;0.127)	all_cancers(12;1.68e-21)|all_epithelial(12;5.86e-16)|all_lung(97;1.19e-05)|Lung NSC(97;2.76e-05)|Breast(109;0.000182)|Medulloblastoma(222;0.0245)|all_neural(223;0.0505)|Esophageal squamous(93;0.0559)		Epithelial(10;8.74e-10)|BRCA - Breast invasive adenocarcinoma(10;1e-08)|all cancers(11;1.46e-08)|OV - Ovarian serous cystadenocarcinoma(99;0.00345)|Lung(977;0.227)		CGGGACCACCCCCCGCAACCA	0.547			NA											35	100					2.40579e-17	3.126e-17	0.00623	1	0
KLRC3	3823	broad.mit.edu	37	12	10573032	10573032	+	Nonsense_Mutation	SNP	G	G	A			TCGA-05-4403-01A-01D-1265-08	TCGA-05-4403-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7e25ac0e-94e4-42f6-ae6f-89d0d21ce09f	a17b5d32-f570-4d2d-9e97-f8b01de1be9f	g.chr12:10573032G>A	uc001qyf.2	-	1	163	c.118C>T	c.(118-120)CAA>TAA	p.Q40*	KLRC3_uc001qyh.2_Intron|KLRC3_uc001qyi.1_Nonsense_Mutation_p.Q40*|KLRC3_uc010shc.1_Nonsense_Mutation_p.Q40*|KLRC3_uc010shd.1_Nonsense_Mutation_p.Q40*	NM_002261	NP_002252	Q07444	NKG2E_HUMAN	killer cell lectin-like receptor subfamily C,	40	Cytoplasmic (Potential).				cellular defense response	integral to membrane	sugar binding|transmembrane receptor activity			ovary(2)|skin(1)	3						AATTCTACTTGGAATATTTCC	0.368			NA											15	77					0	0	0.012319	0	0
KLRC3	3823	broad.mit.edu	37	12	10573045	10573045	+	Silent	SNP	T	T	C			TCGA-05-4403-01A-01D-1265-08	TCGA-05-4403-10A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7e25ac0e-94e4-42f6-ae6f-89d0d21ce09f	a17b5d32-f570-4d2d-9e97-f8b01de1be9f	g.chr12:10573045T>C	uc001qyf.2	-	1	150	c.105A>G	c.(103-105)GAA>GAG	p.E35E	KLRC3_uc001qyh.2_Intron|KLRC3_uc001qyi.1_Silent_p.E35E|KLRC3_uc010shc.1_Silent_p.E35E|KLRC3_uc010shd.1_Silent_p.E35E	NM_002261	NP_002252	Q07444	NKG2E_HUMAN	killer cell lectin-like receptor subfamily C,	35	Cytoplasmic (Potential).				cellular defense response	integral to membrane	sugar binding|transmembrane receptor activity			ovary(2)|skin(1)	3						ATATTTCCTGTTCGGTTCCTG	0.378			NA											11	61					0	0	0.004007	0	0
KLRC3	3823	broad.mit.edu	37	12	10588481	10588481	+	Silent	SNP	T	T	C			TCGA-05-4403-01A-01D-1265-08	TCGA-05-4403-10A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7e25ac0e-94e4-42f6-ae6f-89d0d21ce09f	a17b5d32-f570-4d2d-9e97-f8b01de1be9f	g.chr12:10588481T>C	uc001qyh.2	-	1	112	c.105A>G	c.(103-105)GAA>GAG	p.E35E	KLRC2_uc010she.1_Silent_p.E35E|KLRC2_uc001qyk.2_Silent_p.E35E	NM_002261	NP_002252	Q07444	NKG2E_HUMAN	killer cell lectin-like receptor subfamily C,	35	Cytoplasmic (Potential).				cellular defense response	integral to membrane	sugar binding|transmembrane receptor activity			ovary(2)|skin(1)	3						ATATTTCCTGTTCGGTTCCTG	0.378			NA											10	164					0	0	0.004007	0	0
KRAS	3845	broad.mit.edu	37	12	25398285	25398285	+	Missense_Mutation	SNP	C	C	A	rs121913530		TCGA-05-4403-01A-01D-1265-08	TCGA-05-4403-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7e25ac0e-94e4-42f6-ae6f-89d0d21ce09f	a17b5d32-f570-4d2d-9e97-f8b01de1be9f	g.chr12:25398285C>A	uc001rgp.1	-	2	215	c.34G>T	c.(34-36)GGT>TGT	p.G12C	KRAS_uc001rgq.1_Missense_Mutation_p.G12C|KRAS_uc001rgr.2_RNA	NM_033360	NP_203524	P01116	RASK_HUMAN	c-K-ras2 protein isoform a precursor	12	GTP.		G -> D (in pancreatic carcinoma, GASC and lung carcinoma; somatic mutation).|G -> R (in lung cancer and bladder cancer; somatic mutation).|G -> S (in lung carcinoma and GASC; somatic mutation).|G -> A (in a colorectal cancer sample; somatic mutation).|G -> C (in lung carcinoma; somatic mutation).|G -> V (in lung carcinoma, pancreatic carcinoma, colon cancer and GASC; somatic mutation).		activation of MAPKK activity|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	plasma membrane	GTP binding|GTPase activity|protein binding	p.G12D(7175)|p.G12V(4780)|p.G12C(2482)|p.G12A(1180)|p.G12S(1119)|p.G12R(691)|p.G12?(50)|p.G12F(34)|p.G12G(6)|p.G12N(6)|p.G12L(5)|p.G12I(4)|p.G12_G13insG(4)|p.G12E(3)|p.G12W(3)|p.A11_G12insGA(2)|p.G12Y(2)|p.G12fs*3(1)		large_intestine(12391)|pancreas(3285)|lung(2847)|biliary_tract(521)|ovary(443)|endometrium(339)|haematopoietic_and_lymphoid_tissue(318)|stomach(203)|thyroid(149)|prostate(85)|soft_tissue(77)|small_intestine(62)|upper_aerodigestive_tract(59)|cervix(49)|urinary_tract(48)|skin(38)|liver(31)|breast(28)|testis(17)|oesophagus(15)|central_nervous_system(9)|peritoneum(6)|salivary_gland(6)|kidney(5)|gastrointestinal_tract_(site_indeterminate)(5)|thymus(5)|eye(4)|autonomic_ganglia(2)|bone(2)|genital_tract(1)|penis(1)|adrenal_gland(1)	21052	all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)		OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)			CCTACGCCACCAGCTCCAACT	0.348	Pancreas(8;6 143 191 305 2070 2426 4376 10944 11745 26467 38091 50869)	G12C(UMUC3_URINARY_TRACT)|G12R(CAL62_THYROID)|G12C(CALU1_LUNG)|G12C(NCIH2030_LUNG)|G12C(LU99_LUNG)|G12C(NCIH1792_LUNG)|G12R(KP2_PANCREAS)|G12C(KHM1B_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12C(NCIH2122_LUNG)|G12C(NCIH358_LUNG)|G12R(PSN1_PANCREAS)|G12C(KYSE410_OESOPHAGUS)|G12S(A549_LUNG)|G12R(HUPT3_PANCREAS)|G12R(TCCPAN2_PANCREAS)|G12C(HCC44_LUNG)|G12S(KMS20_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12C(SW1463_LARGE_INTESTINE)|G12C(NCIH23_LUNG)|G12C(LU65_LUNG)|G12C(NCIH1373_LUNG)|G12C(MIAPACA2_PANCREAS)|G12R(HS274T_BREAST)|G12S(LS123_LARGE_INTESTINE)|G12C(SW1573_LUNG)|G12C(SW837_LARGE_INTESTINE)|G12C(OV56_OVARY)|G12C(IALM_LUNG)	119	Mis		pancreatic|colorectal|lung|thyroid|AML|others				Cardiofaciocutaneous_syndrome|Noonan_syndrome	TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)			6	8					0.00198382	0.00207538	0.001984	1	0
CCDC91	55297	broad.mit.edu	37	12	28459852	28459852	+	Nonsense_Mutation	SNP	G	G	T			TCGA-05-4403-01A-01D-1265-08	TCGA-05-4403-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7e25ac0e-94e4-42f6-ae6f-89d0d21ce09f	a17b5d32-f570-4d2d-9e97-f8b01de1be9f	g.chr12:28459852G>T	uc001riq.2	+	4	461	c.445G>T	c.(445-447)GAA>TAA	p.E149*	CCDC91_uc001rio.2_Nonsense_Mutation_p.E119*|CCDC91_uc009zjk.2_RNA|CCDC91_uc001rip.1_Nonsense_Mutation_p.E149*|CCDC91_uc001rir.2_5'UTR|CCDC91_uc009zjl.2_5'UTR	NM_018318	NP_060788	Q7Z6B0	CCD91_HUMAN	GGA binding partner	149	Potential.				protein transport	Golgi apparatus|membrane				central_nervous_system(1)	1	Acute lymphoblastic leukemia(23;0.00718)|all_hematologic(23;0.0113)|Lung SC(9;0.184)					CAAAGTATCTGAAGAAGAAAA	0.313			NA											8	10					1.12685e-05	1.20988e-05	0.004482	1	0
Unknown	0	broad.mit.edu	37	12	31283472	31283472	+	Missense_Mutation	SNP	A	A	C			TCGA-05-4403-01A-01D-1265-08	TCGA-05-4403-10A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7e25ac0e-94e4-42f6-ae6f-89d0d21ce09f	a17b5d32-f570-4d2d-9e97-f8b01de1be9f	g.chr12:31283472A>C	uc010sjy.1	-	23	3044	c.3044T>G	c.(3043-3045)TTT>TGT	p.F1015C						RecName: Full=Ovostatin homolog 1; Flags: Precursor;												NA						CTGCTGCCAAAACACACTATA	0.323			NA											6	8					0	0	0.001168	0	0
Unknown	0	broad.mit.edu	37	12	31283475	31283475	+	Missense_Mutation	SNP	A	A	T			TCGA-05-4403-01A-01D-1265-08	TCGA-05-4403-10A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7e25ac0e-94e4-42f6-ae6f-89d0d21ce09f	a17b5d32-f570-4d2d-9e97-f8b01de1be9f	g.chr12:31283475A>T	uc010sjy.1	-	23	3041	c.3041T>A	c.(3040-3042)GTG>GAG	p.V1014E						RecName: Full=Ovostatin homolog 1; Flags: Precursor;												NA						CTGCCAAAACACACTATAGGA	0.318			NA											6	8					0	0	0.001168	0	0
CNTN1	1272	broad.mit.edu	37	12	41387065	41387065	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4403-01A-01D-1265-08	TCGA-05-4403-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7e25ac0e-94e4-42f6-ae6f-89d0d21ce09f	a17b5d32-f570-4d2d-9e97-f8b01de1be9f	g.chr12:41387065G>T	uc001rmm.1	+	17	2220	c.2107G>T	c.(2107-2109)GGT>TGT	p.G703C	CNTN1_uc001rmn.1_Missense_Mutation_p.G692C	NM_001843	NP_001834	Q12860	CNTN1_HUMAN	contactin 1 isoform 1 precursor	703					axon guidance|cell adhesion|Notch signaling pathway	anchored to membrane|membrane fraction|plasma membrane				lung(4)|ovary(3)|large_intestine(1)|skin(1)	9	all_cancers(12;2.07e-06)|all_epithelial(1;4.26e-06)|Breast(8;0.0716)	Lung NSC(34;0.0211)|all_lung(34;0.0294)				TAAAACAGACGGTGCTGGTAT	0.368			NA											5	31					2.0095e-06	2.21588e-06	0.001984	1	0
MLL2	8085	broad.mit.edu	37	12	49438031	49438031	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4403-01A-01D-1265-08	TCGA-05-4403-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7e25ac0e-94e4-42f6-ae6f-89d0d21ce09f	a17b5d32-f570-4d2d-9e97-f8b01de1be9f	g.chr12:49438031G>A	uc001rta.3	-	21	5140	c.5140C>T	c.(5140-5142)CCT>TCT	p.P1714S		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	1714					chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						TGTGCAGCAGGCCCCTTTTTC	0.622			NA	N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)	OREG0021780	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	15	31					0	0	0.00499	0	0
HOXC12	3228	broad.mit.edu	37	12	54350298	54350298	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4403-01A-01D-1265-08	TCGA-05-4403-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7e25ac0e-94e4-42f6-ae6f-89d0d21ce09f	a17b5d32-f570-4d2d-9e97-f8b01de1be9f	g.chr12:54350298G>A	uc010soq.1	+	2	797	c.797G>A	c.(796-798)AGA>AAA	p.R266K		NM_173860	NP_776272	P31275	HXC12_HUMAN	homeobox C12	266	Homeobox.				multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			upper_aerodigestive_tract(1)	1						CAGAACCGGAGAATGAAAAAG	0.532			NA											6	273					0	0	0.00308	0	0
DTX3	196403	broad.mit.edu	37	12	58000753	58000753	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4403-01A-01D-1265-08	TCGA-05-4403-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7e25ac0e-94e4-42f6-ae6f-89d0d21ce09f	a17b5d32-f570-4d2d-9e97-f8b01de1be9f	g.chr12:58000753G>T	uc001sow.1	+	5	444	c.107G>T	c.(106-108)CGG>CTG	p.R36L	DTX3_uc001sov.1_Missense_Mutation_p.R29L|DTX3_uc001sox.1_Missense_Mutation_p.R29L|DTX3_uc001soy.1_Missense_Mutation_p.R29L	NM_178502	NP_848597	Q8N9I9	DTX3_HUMAN	deltex homolog 3	36					Notch signaling pathway	cytoplasm	zinc ion binding			breast(1)|central_nervous_system(1)	2	Melanoma(17;0.122)					ACCCCAGCCCGGCTGGCCCGG	0.597			NA											110	418					1.02947e-67	1.50009e-67	0.00361	1	0
IRAK3	11213	broad.mit.edu	37	12	66638373	66638373	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4403-01A-01D-1265-08	TCGA-05-4403-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7e25ac0e-94e4-42f6-ae6f-89d0d21ce09f	a17b5d32-f570-4d2d-9e97-f8b01de1be9f	g.chr12:66638373G>C	uc001sth.2	+	9	1097	c.995G>C	c.(994-996)AGC>ACC	p.S332T	IRAK3_uc010ssy.1_Missense_Mutation_p.S271T	NM_007199	NP_009130	Q9Y616	IRAK3_HUMAN	interleukin-1 receptor-associated kinase 3	332	Protein kinase.				interleukin-1-mediated signaling pathway|MyD88-dependent toll-like receptor signaling pathway|negative regulation of innate immune response|negative regulation of interleukin-12 production|negative regulation of interleukin-6 production|negative regulation of macrophage cytokine production|negative regulation of MAP kinase activity|negative regulation of NF-kappaB transcription factor activity|negative regulation of protein catabolic process|negative regulation of protein complex disassembly|negative regulation of toll-like receptor signaling pathway|negative regulation of tumor necrosis factor production|positive regulation of macrophage tolerance induction|positive regulation of NF-kappaB transcription factor activity|response to exogenous dsRNA|response to lipopolysaccharide|response to peptidoglycan	cytoplasm|nucleus	ATP binding|magnesium ion binding|protein heterodimerization activity|protein homodimerization activity|protein serine/threonine kinase activity			lung(3)|ovary(2)|breast(2)|central_nervous_system(1)	8				GBM - Glioblastoma multiforme(28;0.0203)		AATATGACCAGCAGCAGCAGT	0.428			NA											4	154					0	0	0.001168	0	0
DNAH10	196385	broad.mit.edu	37	12	124298433	124298433	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4403-01A-01D-1265-08	TCGA-05-4403-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7e25ac0e-94e4-42f6-ae6f-89d0d21ce09f	a17b5d32-f570-4d2d-9e97-f8b01de1be9f	g.chr12:124298433C>T	uc001uft.3	+	20	3425	c.3400C>T	c.(3400-3402)CGT>TGT	p.R1134C	DNAH10_uc010tav.1_3'UTR|DNAH10_uc010taw.1_3'UTR	NM_207437	NP_997320	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	1134	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(3)|skin(2)|central_nervous_system(1)	6	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		GGAGCGATACCGTACCATGGC	0.378			NA											10	35					0	0	0.00245	0	0
TMEM132D	121256	broad.mit.edu	37	12	129563191	129563191	+	Missense_Mutation	SNP	A	A	T			TCGA-05-4403-01A-01D-1265-08	TCGA-05-4403-10A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7e25ac0e-94e4-42f6-ae6f-89d0d21ce09f	a17b5d32-f570-4d2d-9e97-f8b01de1be9f	g.chr12:129563191A>T	uc009zyl.1	-	8	2331	c.2003T>A	c.(2002-2004)CTC>CAC	p.L668H	TMEM132D_uc001uia.2_Missense_Mutation_p.L206H	NM_133448	NP_597705	Q14C87	T132D_HUMAN	transmembrane protein 132D precursor	668	Extracellular (Potential).					integral to membrane				ovary(10)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	14	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0934)|Breast(359;0.133)		OV - Ovarian serous cystadenocarcinoma(86;0.000288)|Epithelial(86;0.0116)|all cancers(50;0.0246)		CTGCACCCCGAGGTCTGTGAT	0.577			NA											35	162					0	0	0.004878	0	0
ATP8A2	51761	broad.mit.edu	37	13	26116057	26116057	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4403-01A-01D-1265-08	TCGA-05-4403-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7e25ac0e-94e4-42f6-ae6f-89d0d21ce09f	a17b5d32-f570-4d2d-9e97-f8b01de1be9f	g.chr13:26116057G>A	uc001uqk.2	+	9	794	c.652G>A	c.(652-654)GGT>AGT	p.G218S	ATP8A2_uc010tdi.1_Missense_Mutation_p.G178S|ATP8A2_uc010tdj.1_RNA|ATP8A2_uc001uql.1_Missense_Mutation_p.G178S	NM_016529	NP_057613	Q9NTI2	AT8A2_HUMAN	ATPase, aminophospholipid transporter-like,	178	Cytoplasmic (Potential).				ATP biosynthetic process|negative regulation of cell proliferation	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(2)|large_intestine(1)|skin(1)	4		Breast(139;0.0201)|Lung SC(185;0.0225)		all cancers(112;0.043)|OV - Ovarian serous cystadenocarcinoma(117;0.0748)|Epithelial(112;0.079)		AATCTTTTAGGGTTTGAGTCA	0.423			NA											15	98					0	0	0.00499	0	0
FLT1	2321	broad.mit.edu	37	13	29001963	29001963	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4403-01A-01D-1265-08	TCGA-05-4403-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7e25ac0e-94e4-42f6-ae6f-89d0d21ce09f	a17b5d32-f570-4d2d-9e97-f8b01de1be9f	g.chr13:29001963C>T	uc001usb.3	-	9	1487	c.1202G>A	c.(1201-1203)GGG>GAG	p.G401E	FLT1_uc010aar.1_Missense_Mutation_p.G401E|FLT1_uc001usc.3_Missense_Mutation_p.G401E|FLT1_uc010tdp.1_Missense_Mutation_p.G401E	NM_002019	NP_002010	P17948	VGFR1_HUMAN	fms-related tyrosine kinase 1 isoform 1	401	Ig-like C2-type 4.|Extracellular (Potential).				cell differentiation|female pregnancy|positive regulation of vascular endothelial growth factor receptor signaling pathway	extracellular space|Golgi apparatus|integral to plasma membrane|nucleus	ATP binding|growth factor binding|vascular endothelial growth factor receptor activity			lung(10)|central_nervous_system(5)|ovary(3)|stomach(2)|skin(2)|urinary_tract(1)|breast(1)	24	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0262)|Breast(139;0.188)	Colorectal(13;0.000674)	all cancers(112;0.0301)|Epithelial(112;0.155)|GBM - Glioblastoma multiforme(144;0.184)|OV - Ovarian serous cystadenocarcinoma(117;0.205)|Lung(94;0.207)	Sunitinib(DB01268)	TGTATAATTCCCTGCATCCTC	0.398			NA											19	91					0	0	0.008871	0	0
LCP1	3936	broad.mit.edu	37	13	46718649	46718649	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4403-01A-01D-1265-08	TCGA-05-4403-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7e25ac0e-94e4-42f6-ae6f-89d0d21ce09f	a17b5d32-f570-4d2d-9e97-f8b01de1be9f	g.chr13:46718649G>T	uc001vaz.3	-	11	1307	c.1181C>A	c.(1180-1182)ACG>AAG	p.T394K	LCP1_uc010ack.2_5'Flank|LCP1_uc001vay.3_5'UTR|LCP1_uc001vba.3_Missense_Mutation_p.T394K	NM_002298	NP_002289	P13796	PLSL_HUMAN	L-plastin	394	Actin-binding 2.|CH 3.				regulation of intracellular protein transport|T cell activation involved in immune response	cell junction|cytosol|ruffle membrane	calcium ion binding			lung(4)|ovary(3)	7		Lung NSC(96;1.27e-05)|Breast(56;8.04e-05)|Prostate(109;0.00217)|Hepatocellular(98;0.0207)|Lung SC(185;0.0262)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;5.39e-05)		CTCTTCTCTCGTCTCACCTAG	0.388			NA	T	BCL6	NHL 								23	66					2.89027e-11	3.50961e-11	0.002299	1	0
PCDH17	27253	broad.mit.edu	37	13	58207613	58207613	+	Silent	SNP	T	T	C			TCGA-05-4403-01A-01D-1265-08	TCGA-05-4403-10A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7e25ac0e-94e4-42f6-ae6f-89d0d21ce09f	a17b5d32-f570-4d2d-9e97-f8b01de1be9f	g.chr13:58207613T>C	uc001vhq.1	+	1	1825	c.933T>C	c.(931-933)TAT>TAC	p.Y311Y	PCDH17_uc010aec.1_Silent_p.Y311Y	NM_001040429	NP_001035519	O14917	PCD17_HUMAN	protocadherin 17 precursor	311	Extracellular (Potential).|Cadherin 3.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			ovary(3)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	7		Lung NSC(96;0.027)|Prostate(109;0.0453)|Breast(118;0.128)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;1.06e-05)		ATCTGGACTATGAGGAAAACG	0.587	Melanoma(72;952 1291 1619 12849 33676)		NA											19	75					0	0	0.007413	0	0
P704P	641455	broad.mit.edu	37	14	20020054	20020054	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4403-01A-01D-1265-08	TCGA-05-4403-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7e25ac0e-94e4-42f6-ae6f-89d0d21ce09f	a17b5d32-f570-4d2d-9e97-f8b01de1be9f	g.chr14:20020054G>T	uc001vwc.3	-	1	219	c.167C>A	c.(166-168)ACA>AAA	p.T56K	P704P_uc001vwb.3_RNA	NM_001145442	NP_001138914	A6NI47	POTEM_HUMAN	prostate-specific P704P	56											0						GCTCCTGAGTGTCTTCATAGC	0.612			NA											11	349					5.03518e-11	6.07797e-11	0.007413	1	0
OR4K2	390431	broad.mit.edu	37	14	20345046	20345046	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4403-01A-01D-1265-08	TCGA-05-4403-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7e25ac0e-94e4-42f6-ae6f-89d0d21ce09f	a17b5d32-f570-4d2d-9e97-f8b01de1be9f	g.chr14:20345046C>A	uc001vwh.1	+	1	620	c.620C>A	c.(619-621)GCG>GAG	p.A207E		NM_001005501	NP_001005501	Q8NGD2	OR4K2_HUMAN	olfactory receptor, family 4, subfamily K,	207	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(2)	4	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		GGCATAATTGCGTTGTCCTGT	0.398			NA											34	362					3.86903e-22	5.29719e-22	0.002836	1	0
MYH7	4625	broad.mit.edu	37	14	23892851	23892851	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4403-01A-01D-1265-08	TCGA-05-4403-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7e25ac0e-94e4-42f6-ae6f-89d0d21ce09f	a17b5d32-f570-4d2d-9e97-f8b01de1be9f	g.chr14:23892851C>T	uc001wjx.2	-	24	3110	c.3004G>A	c.(3004-3006)GCC>ACC	p.A1002T		NM_000257	NP_000248	P12883	MYH7_HUMAN	myosin, heavy chain 7, cardiac muscle, beta	1002	Potential.				adult heart development|muscle filament sliding|regulation of heart rate|ventricular cardiac muscle tissue morphogenesis	focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(3)|skin(1)	4	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00725)		TGTTGGTGGGCCTCTTGCAGA	0.542			NA											76	215					0	0	0.00361	0	0
NEDD8	4738	broad.mit.edu	37	14	24687414	24687414	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4403-01A-01D-1265-08	TCGA-05-4403-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7e25ac0e-94e4-42f6-ae6f-89d0d21ce09f	a17b5d32-f570-4d2d-9e97-f8b01de1be9f	g.chr14:24687414C>T	uc001wnn.2	-	3	177	c.74G>A	c.(73-75)CGA>CAA	p.R25Q	CHMP4A_uc001wnj.2_5'Flank|MDP1_uc001wnk.1_5'Flank|CHMP4A_uc001wnm.1_5'Flank|MDP1_uc001wnl.1_5'Flank|NEDD8_uc001wno.2_RNA	NM_006156	NP_006147	Q15843	NEDD8_HUMAN	neural precursor cell expressed, developmentally	25					anatomical structure morphogenesis|protein neddylation|ubiquitin-dependent protein catabolic process	nucleus	ubiquitin protein ligase binding				0				GBM - Glioblastoma multiforme(265;0.0186)		CTCCTTGATTCGCTCCACCTT	0.517			NA											31	97					0	0	0.009535	0	0
SEC23A	10484	broad.mit.edu	37	14	39530984	39530984	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4403-01A-01D-1265-08	TCGA-05-4403-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7e25ac0e-94e4-42f6-ae6f-89d0d21ce09f	a17b5d32-f570-4d2d-9e97-f8b01de1be9f	g.chr14:39530984G>A	uc001wup.1	-	13	1713	c.1490C>T	c.(1489-1491)ACC>ATC	p.T497I	SEC23A_uc010tqa.1_Missense_Mutation_p.T359I|SEC23A_uc010tqb.1_Missense_Mutation_p.T468I|SEC23A_uc010tqc.1_Missense_Mutation_p.T359I	NM_006364	NP_006355	Q15436	SC23A_HUMAN	SEC23-related protein A	497					COPII vesicle coating|intracellular protein transport|post-translational protein modification|protein N-linked glycosylation via asparagine	COPII vesicle coat|cytosol|Golgi membrane|smooth endoplasmic reticulum membrane	protein binding|zinc ion binding			ovary(4)|upper_aerodigestive_tract(1)	5	Hepatocellular(127;0.213)		Lung(238;0.00047)|LUAD - Lung adenocarcinoma(48;0.000565)	GBM - Glioblastoma multiforme(112;0.0151)		AGCAATGGTGGTCACTCGGAT	0.428			NA											15	85					0	0	0.007413	0	0
OTX2	5015	broad.mit.edu	37	14	57268910	57268910	+	Nonsense_Mutation	SNP	G	G	T			TCGA-05-4403-01A-01D-1265-08	TCGA-05-4403-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7e25ac0e-94e4-42f6-ae6f-89d0d21ce09f	a17b5d32-f570-4d2d-9e97-f8b01de1be9f	g.chr14:57268910G>T	uc001xcp.2	-	3	584	c.413C>A	c.(412-414)TCA>TAA	p.S138*	OTX2_uc010aou.2_Nonsense_Mutation_p.S138*|OTX2_uc001xcq.2_Nonsense_Mutation_p.S146*	NM_172337	NP_758840	P32243	OTX2_HUMAN	orthodenticle homeobox 2 isoform b	138					axon guidance|forebrain development|midbrain development|positive regulation of embryonic development|positive regulation of gastrulation|primitive streak formation|protein complex assembly|regulation of fibroblast growth factor receptor signaling pathway|regulation of smoothened signaling pathway	growth cone|nucleus|protein complex	eukaryotic initiation factor 4E binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|sequence-specific DNA binding			ovary(1)	1	Medulloblastoma(1;0.00184)|all_neural(1;0.00414)					GGTCGGGACTGAGGTGCTAGA	0.542			NA											38	57					6.70999e-13	8.34657e-13	0.004289	1	0
MARK3	4140	broad.mit.edu	37	14	103932328	103932328	+	Nonsense_Mutation	SNP	T	T	G			TCGA-05-4403-01A-01D-1265-08	TCGA-05-4403-10A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7e25ac0e-94e4-42f6-ae6f-89d0d21ce09f	a17b5d32-f570-4d2d-9e97-f8b01de1be9f	g.chr14:103932328T>G	uc001ymz.3	+	9	1463	c.797T>G	c.(796-798)TTA>TGA	p.L266*	MARK3_uc001ymx.3_Nonsense_Mutation_p.L266*|MARK3_uc001ymw.3_Nonsense_Mutation_p.L266*|MARK3_uc001yna.3_Nonsense_Mutation_p.L266*|MARK3_uc001ymy.3_Nonsense_Mutation_p.L187*|MARK3_uc010awp.2_Nonsense_Mutation_p.L289*|MARK3_uc010tyb.1_Nonsense_Mutation_p.L77*	NM_001128918	NP_001122390	P27448	MARK3_HUMAN	MAP/microtubule affinity-regulating kinase 3	266	Protein kinase.						ATP binding|protein binding|protein serine/threonine kinase activity			central_nervous_system(2)|ovary(1)|stomach(1)	4		Melanoma(154;0.155)	Epithelial(46;0.241)			GAGAGAGTATTAAGAGGGAAA	0.403			NA											33	53					0	0	0.002836	0	0
PACS2	23241	broad.mit.edu	37	14	105860917	105860917	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4403-01A-01D-1265-08	TCGA-05-4403-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7e25ac0e-94e4-42f6-ae6f-89d0d21ce09f	a17b5d32-f570-4d2d-9e97-f8b01de1be9f	g.chr14:105860917G>T	uc001yqt.2	+	24	2753	c.2578G>T	c.(2578-2580)GAC>TAC	p.D860Y	PACS2_uc001yqs.2_Missense_Mutation_p.D785Y|PACS2_uc001yqv.2_Missense_Mutation_p.D864Y|PACS2_uc001yqu.2_Missense_Mutation_p.D875Y	NM_015197	NP_056012	Q86VP3	PACS2_HUMAN	phosphofurin acidic cluster sorting protein 2	860					apoptosis|interspecies interaction between organisms	endoplasmic reticulum lumen|mitochondrion				pancreas(1)	1		all_cancers(154;0.0351)|all_epithelial(191;0.153)|Melanoma(154;0.155)	OV - Ovarian serous cystadenocarcinoma(23;0.0145)|Epithelial(46;0.036)	Epithelial(152;0.138)		GGAGTGCAGCGACGTCAAGTT	0.458			NA											45	56					1.61004e-24	2.24964e-24	0.00361	1	0
OR4N4	283694	broad.mit.edu	37	15	22382965	22382965	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4403-01A-01D-1265-08	TCGA-05-4403-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7e25ac0e-94e4-42f6-ae6f-89d0d21ce09f	a17b5d32-f570-4d2d-9e97-f8b01de1be9f	g.chr15:22382965C>A	uc001yuc.1	+	7	1474	c.493C>A	c.(493-495)CGC>AGC	p.R165S	LOC727924_uc001yub.1_Intron|OR4N4_uc010tzv.1_Missense_Mutation_p.R165S	NM_001005241	NP_001005241	Q8N0Y3	OR4N4_HUMAN	olfactory receptor, family 4, subfamily N,	165	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(4)|skin(1)	5		all_cancers(20;1.94e-20)|all_epithelial(15;3.94e-18)|Lung NSC(15;8.53e-15)|all_lung(15;2.87e-14)|Breast(32;0.00519)|Colorectal(260;0.101)	GBM - Glioblastoma multiforme(6;0.124)	all cancers(64;1.64e-11)|Epithelial(43;5.81e-10)|BRCA - Breast invasive adenocarcinoma(123;0.000255)|Kidney(6;0.00736)|KIRC - Kidney renal clear cell carcinoma(6;0.0135)|GBM - Glioblastoma multiforme(186;0.0963)		CCTCATCCTCCGCTTGCCTTT	0.517			NA											19	317					1.96292e-10	2.34173e-10	0.010504	1	0
SCG3	29106	broad.mit.edu	37	15	51988120	51988120	+	Missense_Mutation	SNP	T	T	A			TCGA-05-4403-01A-01D-1265-08	TCGA-05-4403-10A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7e25ac0e-94e4-42f6-ae6f-89d0d21ce09f	a17b5d32-f570-4d2d-9e97-f8b01de1be9f	g.chr15:51988120T>A	uc002abh.2	+	8	1325	c.917T>A	c.(916-918)CTG>CAG	p.L306Q	SCG3_uc010ufz.1_Missense_Mutation_p.L74Q	NM_013243	NP_037375	Q8WXD2	SCG3_HUMAN	secretogranin III isoform 1 precursor	306					platelet activation|platelet degranulation	extracellular region|stored secretory granule				ovary(1)	1				all cancers(107;0.00488)		ATGAAAACACTGATTGACTTT	0.348			NA											51	247					0	0	0.00361	0	0
ITGA11	22801	broad.mit.edu	37	15	68695330	68695330	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4403-01A-01D-1265-08	TCGA-05-4403-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7e25ac0e-94e4-42f6-ae6f-89d0d21ce09f	a17b5d32-f570-4d2d-9e97-f8b01de1be9f	g.chr15:68695330G>A	uc002ari.2	-	2	178	c.91C>T	c.(91-93)CGG>TGG	p.R31W	ITGA11_uc010bib.2_Missense_Mutation_p.R31W	NM_001004439	NP_001004439	Q9UKX5	ITA11_HUMAN	integrin, alpha 11 precursor	31	FG-GAP 1.|Extracellular (Potential).				cell-matrix adhesion|integrin-mediated signaling pathway|muscle organ development	integrin complex	collagen binding|receptor activity			kidney(2)|pancreas(1)	3					Tirofiban(DB00775)	GGGATGACCCGGGGCTTCCTG	0.617			NA											11	47					0	0	0.001368	0	0
CCNF	899	broad.mit.edu	37	16	2481129	2481129	+	Splice_Site	SNP	A	A	T	rs111704404		TCGA-05-4403-01A-01D-1265-08	TCGA-05-4403-10A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7e25ac0e-94e4-42f6-ae6f-89d0d21ce09f	a17b5d32-f570-4d2d-9e97-f8b01de1be9f	g.chr16:2481129A>T	uc002cqd.1	+	2	105	c.17_splice	c.e2-2	p.V6_splice	CCNF_uc002cqe.1_Splice_Site	NM_001761	NP_001752	P41002	CCNF_HUMAN	cyclin F						cell division|mitosis|negative regulation of centrosome duplication|protein ubiquitination|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	centriole|nucleus|SCF ubiquitin ligase complex	protein binding			central_nervous_system(1)|kidney(1)	2		Ovarian(90;0.17)				TTTTTCCTTCAGTGGTCCACT	0.403			NA											57	227					0	0	0.00361	0	0
ZNF213	7760	broad.mit.edu	37	16	3187321	3187321	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4403-01A-01D-1265-08	TCGA-05-4403-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7e25ac0e-94e4-42f6-ae6f-89d0d21ce09f	a17b5d32-f570-4d2d-9e97-f8b01de1be9f	g.chr16:3187321G>A	uc010uws.1	+	2	487	c.40G>A	c.(40-42)GAG>AAG	p.E14K	ZNF213_uc002cud.2_RNA|ZNF213_uc010btf.2_Missense_Mutation_p.E14K|ZNF213_uc010bth.2_Missense_Mutation_p.E14K|ZNF213_uc010uwt.1_Missense_Mutation_p.E14K	NM_004220	NP_004211	O14771	ZN213_HUMAN	zinc finger protein 213	14					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0						GGCCCCTGGGGAGGGAGAAGG	0.622			NA											27	92					0	0	0.008361	0	0
SH2B1	25970	broad.mit.edu	37	16	28877776	28877776	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4403-01A-01D-1265-08	TCGA-05-4403-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7e25ac0e-94e4-42f6-ae6f-89d0d21ce09f	a17b5d32-f570-4d2d-9e97-f8b01de1be9f	g.chr16:28877776G>T	uc002dri.2	+	4	800	c.361G>T	c.(361-363)GGC>TGC	p.G121C	uc010vct.1_Intron|SH2B1_uc010vdc.1_Intron|SH2B1_uc002drj.2_Missense_Mutation_p.G121C|SH2B1_uc002drk.2_Missense_Mutation_p.G121C|SH2B1_uc002drl.2_Missense_Mutation_p.G121C|SH2B1_uc010vdd.1_Intron|SH2B1_uc010vde.1_Missense_Mutation_p.G121C|SH2B1_uc002drm.2_Missense_Mutation_p.G121C	NM_001145795	NP_001139267	Q9NRF2	SH2B1_HUMAN	SH2B adaptor protein 1 isoform 1	121	Interaction with JAK2 (low-affinity binding; independent of JAK2 phosphorylation) (By similarity).|Interaction with RAC1 (By similarity).|Required for NGF signaling (By similarity).				blood coagulation|intracellular signal transduction	cytosol|membrane|nucleus	signal transducer activity			ovary(2)	2						GGCTGTGCTGGGCCCTTCTCG	0.632			NA											20	55					8.34094e-07	9.34918e-07	0.008871	1	0
ITGAL	3683	broad.mit.edu	37	16	30505572	30505572	+	Missense_Mutation	SNP	C	C	T	rs145951975		TCGA-05-4403-01A-01D-1265-08	TCGA-05-4403-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7e25ac0e-94e4-42f6-ae6f-89d0d21ce09f	a17b5d32-f570-4d2d-9e97-f8b01de1be9f	g.chr16:30505572C>T	uc002dyi.3	+	12	1429	c.1253C>T	c.(1252-1254)TCG>TTG	p.S418L	ITGAL_uc002dyj.3_Missense_Mutation_p.S335L|ITGAL_uc010vev.1_Intron	NM_002209	NP_002200	P20701	ITAL_HUMAN	integrin alpha L isoform a precursor	418	FG-GAP 4.|Extracellular (Potential).				blood coagulation|heterophilic cell-cell adhesion|inflammatory response|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|regulation of immune response|T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell	integrin complex	cell adhesion molecule binding|receptor activity			ovary(3)|lung(3)|central_nervous_system(3)|breast(1)	10					Efalizumab(DB00095)	CAAAAGACTTCGTTGCTGGCC	0.602	NSCLC(110;1462 1641 3311 33990 49495)		NA											24	124					0	0	0.003954	0	0
SETD6	79918	broad.mit.edu	37	16	58550115	58550115	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4403-01A-01D-1265-08	TCGA-05-4403-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7e25ac0e-94e4-42f6-ae6f-89d0d21ce09f	a17b5d32-f570-4d2d-9e97-f8b01de1be9f	g.chr16:58550115C>T	uc002ens.2	+	3	403	c.344C>T	c.(343-345)GCG>GTG	p.A115V	SETD6_uc010cdl.2_Missense_Mutation_p.A115V|SETD6_uc002enr.2_Missense_Mutation_p.A91V|SETD6_uc010cdm.2_RNA|SETD6_uc010vij.1_Missense_Mutation_p.A39V	NM_001160305	NP_001153777	Q8TBK2	SETD6_HUMAN	SET domain containing 6 isoform a	115	SET.				negative regulation of NF-kappaB transcription factor activity|peptidyl-lysine monomethylation|regulation of inflammatory response	nucleus	NF-kappaB binding|protein-lysine N-methyltransferase activity			ovary(1)	1						GAGCGAGTTGCGCTGCAGAGC	0.498			NA											9	51					0	0	0.006214	0	0
PDP2	57546	broad.mit.edu	37	16	66919297	66919297	+	Silent	SNP	C	C	G			TCGA-05-4403-01A-01D-1265-08	TCGA-05-4403-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7e25ac0e-94e4-42f6-ae6f-89d0d21ce09f	a17b5d32-f570-4d2d-9e97-f8b01de1be9f	g.chr16:66919297C>G	uc002eqk.1	+	2	1272	c.1110C>G	c.(1108-1110)ACC>ACG	p.T370T		NM_020786	NP_065837	Q9P2J9	PDP2_HUMAN	pyruvate dehydrogenase phosphatase isoenzyme 2	370					pyruvate metabolic process|regulation of acetyl-CoA biosynthetic process from pyruvate	mitochondrial matrix|protein serine/threonine phosphatase complex	[pyruvate dehydrogenase (lipoamide)] phosphatase activity|metal ion binding			ovary(1)	1		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.088)|Epithelial(162;0.204)		GCTTCAATACCGAGGCCCTCA	0.577			NA											36	124					0	0	0.003755	0	0
ZCCHC14	23174	broad.mit.edu	37	16	87446014	87446014	+	Silent	SNP	A	A	G			TCGA-05-4403-01A-01D-1265-08	TCGA-05-4403-10A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7e25ac0e-94e4-42f6-ae6f-89d0d21ce09f	a17b5d32-f570-4d2d-9e97-f8b01de1be9f	g.chr16:87446014A>G	uc002fjz.1	-	12	1929	c.1902T>C	c.(1900-1902)CGT>CGC	p.R634R	ZCCHC14_uc002fka.1_RNA|ZCCHC14_uc002fkb.2_Silent_p.R410R	NM_015144	NP_055959	Q8WYQ9	ZCH14_HUMAN	zinc finger, CCHC domain containing 14	634					cell communication		nucleic acid binding|phosphatidylinositol binding|zinc ion binding			upper_aerodigestive_tract(1)|breast(1)	2				BRCA - Breast invasive adenocarcinoma(80;0.0285)		TGATGGGCGGACGGGCGGCGT	0.607			NA											33	193					0	0	0.004878	0	0
ZMYND15	84225	broad.mit.edu	37	17	4648196	4648196	+	Silent	SNP	G	G	A			TCGA-05-4403-01A-01D-1265-08	TCGA-05-4403-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7e25ac0e-94e4-42f6-ae6f-89d0d21ce09f	a17b5d32-f570-4d2d-9e97-f8b01de1be9f	g.chr17:4648196G>A	uc002fyt.2	+	11	1791	c.1752G>A	c.(1750-1752)ACG>ACA	p.T584T	ZMYND15_uc002fyv.2_Silent_p.T623T|ZMYND15_uc002fyu.2_Silent_p.T631T	NM_032265	NP_115641	Q9H091	ZMY15_HUMAN	zinc finger, MYND-type containing 15 isoform 2	584							zinc ion binding				0						TCAAGGATACGTGGCTGAGGT	0.587			NA											31	143					0	0	0.002836	0	0
MED1	5469	broad.mit.edu	37	17	37564483	37564483	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4403-01A-01D-1265-08	TCGA-05-4403-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7e25ac0e-94e4-42f6-ae6f-89d0d21ce09f	a17b5d32-f570-4d2d-9e97-f8b01de1be9f	g.chr17:37564483C>A	uc002hrv.3	-	17	4203	c.3991G>T	c.(3991-3993)GTG>TTG	p.V1331L	MED1_uc010wee.1_Missense_Mutation_p.V1159L|MED1_uc002hru.2_Intron	NM_004774	NP_004765	Q15648	MED1_HUMAN	mediator complex subunit 1	1331	Ser-rich.|Interaction with TP53.				androgen biosynthetic process|androgen receptor signaling pathway|cellular lipid metabolic process|fat cell differentiation|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|transcription initiation from RNA polymerase II promoter	mediator complex	DNA binding|estrogen receptor binding|ligand-dependent nuclear receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|peroxisome proliferator activated receptor binding|receptor activity|retinoic acid receptor binding|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			lung(2)|ovary(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	8		Ovarian(249;1.78e-06)|Lung SC(565;0.0262)	Lung(15;0.0178)|LUAD - Lung adenocarcinoma(14;0.146)	UCEC - Uterine corpus endometrioid carcinoma (308;6.64e-05)|BRCA - Breast invasive adenocarcinoma(366;0.00136)|READ - Rectum adenocarcinoma(1115;0.0649)		TTTGTGCTCACCCCCATCTGG	0.493	Pancreas(21;279 768 2492 4877 24026)		NA								HNSCC(31;0.082)			43	156					1.06522e-23	1.47826e-23	0.013114	1	0
C17orf104	284071	broad.mit.edu	37	17	42745037	42745037	+	Silent	SNP	T	T	C			TCGA-05-4403-01A-01D-1265-08	TCGA-05-4403-10A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7e25ac0e-94e4-42f6-ae6f-89d0d21ce09f	a17b5d32-f570-4d2d-9e97-f8b01de1be9f	g.chr17:42745037T>C	uc010czv.2	+	5	1758	c.1758T>C	c.(1756-1758)AAT>AAC	p.N586N	C17orf104_uc002igy.1_Silent_p.N420N|C17orf104_uc002igz.3_Silent_p.N420N|C17orf104_uc010wja.1_RNA|C17orf104_uc002iha.2_Silent_p.N420N	NM_001145080	NP_001138552	A2RUB1	CQ104_HUMAN	hypothetical protein LOC284071	586										central_nervous_system(1)	1						AGCAGCCAAATGGATTTTGTG	0.353			NA											10	21					0	0	0.006214	0	0
ANKFN1	162282	broad.mit.edu	37	17	54554984	54554984	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4403-01A-01D-1265-08	TCGA-05-4403-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7e25ac0e-94e4-42f6-ae6f-89d0d21ce09f	a17b5d32-f570-4d2d-9e97-f8b01de1be9f	g.chr17:54554984G>C	uc002iun.1	+	15	1953	c.1918G>C	c.(1918-1920)GTG>CTG	p.V640L		NM_153228	NP_694960	Q8N957	ANKF1_HUMAN	ankyrin-repeat and fibronectin type III domain	640										large_intestine(1)|ovary(1)	2						TCTCTGCCACGTGAAGATCCG	0.408			NA											52	200					0	0	0.00361	0	0
TBC1D3P2	440452	broad.mit.edu	37	17	60348763	60348763	+	Silent	SNP	G	G	A			TCGA-05-4403-01A-01D-1265-08	TCGA-05-4403-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7e25ac0e-94e4-42f6-ae6f-89d0d21ce09f	a17b5d32-f570-4d2d-9e97-f8b01de1be9f	g.chr17:60348763G>A	uc002izq.2	-	6	454	c.342C>T	c.(340-342)CTC>CTT	p.L114L	TBC1D3P2_uc010woz.1_RNA|uc010wpa.1_5'Flank					SubName: Full=Putative uncharacterized protein TBC1D3E;												0						CAATGTTCAGGAGGACTGACC	0.557			NA											25	86					0	0	0.00874	0	0
SFRS2	6427	broad.mit.edu	37	17	74733003	74733003	+	Silent	SNP	C	C	G			TCGA-05-4403-01A-01D-1265-08	TCGA-05-4403-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7e25ac0e-94e4-42f6-ae6f-89d0d21ce09f	a17b5d32-f570-4d2d-9e97-f8b01de1be9f	g.chr17:74733003C>G	uc002jsv.2	-	1	410	c.240G>C	c.(238-240)CTG>CTC	p.L80L	SFRS2_uc002jsw.1_5'Flank|SFRS2_uc002jsx.1_RNA|SFRS2_uc002jsy.3_Silent_p.L80L|SFRS2_uc010wtg.1_Silent_p.L80L|MFSD11_uc002jsz.1_RNA|MFSD11_uc002jta.2_5'UTR|MIR636_hsa-mir-636|MI0003651_5'Flank|MFSD11_uc002jtb.2_5'Flank|MFSD11_uc010dha.2_5'Flank|MFSD11_uc002jtc.2_5'Flank|MFSD11_uc002jtd.3_5'Flank|MFSD11_uc010dhb.2_5'Flank|MFSD11_uc002jte.2_5'Flank	NM_003016	NP_003007	Q01130	SRSF2_HUMAN	splicing factor, arginine/serine-rich 2	80	RRM.				mRNA 3'-end processing|mRNA export from nucleus|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	nuclear speck	nucleotide binding|protein binding|RNA binding|transcription corepressor activity				0						CGCGGCCGTCCAGCACGGCCC	0.716			NA											6	28					0	0	0.004482	0	0
LAMA1	284217	broad.mit.edu	37	18	7036072	7036072	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4403-01A-01D-1265-08	TCGA-05-4403-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7e25ac0e-94e4-42f6-ae6f-89d0d21ce09f	a17b5d32-f570-4d2d-9e97-f8b01de1be9f	g.chr18:7036072C>T	uc002knm.2	-	13	1847	c.1753G>A	c.(1753-1755)GGA>AGA	p.G585R	LAMA1_uc010wzj.1_Missense_Mutation_p.G61R	NM_005559	NP_005550	P25391	LAMA1_HUMAN	laminin, alpha 1 precursor	585	Laminin IV type A 1.				axon guidance|cell adhesion|cell surface receptor linked signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	extracellular space|laminin-1 complex|laminin-3 complex	extracellular matrix structural constituent|receptor binding			ovary(8)|large_intestine(4)|upper_aerodigestive_tract(2)|breast(2)|skin(2)|pancreas(2)|central_nervous_system(1)	21		Colorectal(10;0.172)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	TTCAGGAATCCGCCAAACGCA	0.458			NA											10	43					0	0	0.001368	0	0
DSC1	1823	broad.mit.edu	37	18	28714691	28714691	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4403-01A-01D-1265-08	TCGA-05-4403-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7e25ac0e-94e4-42f6-ae6f-89d0d21ce09f	a17b5d32-f570-4d2d-9e97-f8b01de1be9f	g.chr18:28714691C>A	uc002kwn.2	-	12	1982	c.1720G>T	c.(1720-1722)GCA>TCA	p.A574S	DSC1_uc002kwm.2_Missense_Mutation_p.A574S	NM_024421	NP_077739	Q08554	DSC1_HUMAN	desmocollin 1 isoform Dsc1a preproprotein	574	Extracellular (Potential).|Cadherin 4.				homophilic cell adhesion	desmosome|gap junction|integral to membrane|membrane fraction	calcium ion binding			ovary(3)|skin(1)	4			OV - Ovarian serous cystadenocarcinoma(10;0.00778)			ATTTGAGGTGCGTGATCGTTG	0.368			NA											6	9					1.06961e-07	1.23978e-07	0.00308	1	0
SETBP1	26040	broad.mit.edu	37	18	42532845	42532845	+	Silent	SNP	C	C	A			TCGA-05-4403-01A-01D-1265-08	TCGA-05-4403-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7e25ac0e-94e4-42f6-ae6f-89d0d21ce09f	a17b5d32-f570-4d2d-9e97-f8b01de1be9f	g.chr18:42532845C>A	uc010dni.2	+	4	3836	c.3540C>A	c.(3538-3540)GGC>GGA	p.G1180G		NM_015559	NP_056374	Q9Y6X0	SETBP_HUMAN	SET binding protein 1 isoform a	1180						nucleus	DNA binding			upper_aerodigestive_tract(2)|large_intestine(1)	3				Colorectal(1;0.0622)|COAD - Colon adenocarcinoma(74;0.201)		AAGCCACAGGCTTCTCCAGCC	0.522			NA							Schinzel-Giedion_syndrome				9	94					2.27111e-07	2.5883e-07	0.001368	1	0
MUC16	94025	broad.mit.edu	37	19	9045932	9045932	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4403-01A-01D-1265-08	TCGA-05-4403-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7e25ac0e-94e4-42f6-ae6f-89d0d21ce09f	a17b5d32-f570-4d2d-9e97-f8b01de1be9f	g.chr19:9045932G>A	uc002mkp.2	-	5	35903	c.35699C>T	c.(35698-35700)TCT>TTT	p.S11900F		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	11902	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GGAAAGCCCAGAGACAGCAGG	0.502			NA											35	162					0	0	0.004289	0	0
MUC16	94025	broad.mit.edu	37	19	9088208	9088208	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4403-01A-01D-1265-08	TCGA-05-4403-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7e25ac0e-94e4-42f6-ae6f-89d0d21ce09f	a17b5d32-f570-4d2d-9e97-f8b01de1be9f	g.chr19:9088208G>C	uc002mkp.2	-	1	3811	c.3607C>G	c.(3607-3609)CCA>GCA	p.P1203A		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	1203	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						ATATTACTTGGTGTCAAGGAA	0.478			NA											84	270					0	0	0.00361	0	0
KCNN1	3780	broad.mit.edu	37	19	18096157	18096157	+	Silent	SNP	G	G	A			TCGA-05-4403-01A-01D-1265-08	TCGA-05-4403-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7e25ac0e-94e4-42f6-ae6f-89d0d21ce09f	a17b5d32-f570-4d2d-9e97-f8b01de1be9f	g.chr19:18096157G>A	uc002nht.2	+	6	1264	c.954G>A	c.(952-954)CTG>CTA	p.L318L	KCNN1_uc010xqa.1_Silent_p.L318L	NM_002248	NP_002239	Q92952	KCNN1_HUMAN	potassium intermediate/small conductance	318					synaptic transmission	voltage-gated potassium channel complex	calmodulin binding|small conductance calcium-activated potassium channel activity				0						GCAACTTCCTGGGGGCCATGT	0.592			NA											7	24					0	0	0.001984	0	0
HKR1	284459	broad.mit.edu	37	19	37854370	37854370	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4403-01A-01D-1265-08	TCGA-05-4403-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7e25ac0e-94e4-42f6-ae6f-89d0d21ce09f	a17b5d32-f570-4d2d-9e97-f8b01de1be9f	g.chr19:37854370G>T	uc002ogb.2	+	6	1942	c.1673G>T	c.(1672-1674)TGT>TTT	p.C558F	HKR1_uc002ofx.2_Missense_Mutation_p.C274F|HKR1_uc002ofy.2_Missense_Mutation_p.C274F|HKR1_uc002oga.2_Missense_Mutation_p.C540F|HKR1_uc010xto.1_Missense_Mutation_p.C540F|HKR1_uc002ogc.2_Missense_Mutation_p.C539F|HKR1_uc010xtp.1_Missense_Mutation_p.C497F|HKR1_uc002ogd.2_Missense_Mutation_p.C497F	NM_181786	NP_861451	P10072	HKR1_HUMAN	GLI-Kruppel family member HKR1	558	C2H2-type 10.				multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			TGCAGGGAGTGTGGCAGAAGG	0.502			NA											15	56					1.3612e-06	1.50916e-06	0.003163	1	0
RYR1	6261	broad.mit.edu	37	19	38985136	38985136	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4403-01A-01D-1265-08	TCGA-05-4403-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7e25ac0e-94e4-42f6-ae6f-89d0d21ce09f	a17b5d32-f570-4d2d-9e97-f8b01de1be9f	g.chr19:38985136G>T	uc002oit.2	+	39	6549	c.6419G>T	c.(6418-6420)CGG>CTG	p.R2140L	RYR1_uc002oiu.2_Missense_Mutation_p.R2140L|RYR1_uc002oiv.1_5'Flank	NM_000540	NP_000531	P21817	RYR1_HUMAN	skeletal muscle ryanodine receptor isoform 1	2140	Cytoplasmic.|6 X approximate repeats.				muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(7)|pancreas(2)|breast(1)|central_nervous_system(1)|skin(1)	12	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	GCCCTGCCGCGGGCGTACACC	0.672			NA											13	55					3.99206e-14	5.05826e-14	0.007413	1	0
DYRK1B	9149	broad.mit.edu	37	19	40317399	40317399	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4403-01A-01D-1265-08	TCGA-05-4403-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7e25ac0e-94e4-42f6-ae6f-89d0d21ce09f	a17b5d32-f570-4d2d-9e97-f8b01de1be9f	g.chr19:40317399C>A	uc002omj.2	-	9	1604	c.1324G>T	c.(1324-1326)GGC>TGC	p.G442C	DYRK1B_uc002omi.2_Missense_Mutation_p.G414C|DYRK1B_uc002omk.2_Missense_Mutation_p.G402C	NM_004714	NP_004705	Q9Y463	DYR1B_HUMAN	dual-specificity tyrosine-(Y)-phosphorylation	442					positive regulation of transcription, DNA-dependent	nucleus	ATP binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|transcription coactivator activity			ovary(4)|stomach(1)|central_nervous_system(1)|skin(1)	7	all_cancers(60;5.79e-06)|all_lung(34;5.2e-08)|Lung NSC(34;6.14e-08)|Ovarian(47;0.06)		Epithelial(26;5.74e-25)|OV - Ovarian serous cystadenocarcinoma(5;3.13e-24)|all cancers(26;8.59e-23)			CCTGCCGGGCCCGTGTTGGTG	0.721			NA											4	7					3.59834e-05	3.84325e-05	0.001168	1	0
NLRP12	91662	broad.mit.edu	37	19	54314312	54314312	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4403-01A-01D-1265-08	TCGA-05-4403-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7e25ac0e-94e4-42f6-ae6f-89d0d21ce09f	a17b5d32-f570-4d2d-9e97-f8b01de1be9f	g.chr19:54314312C>T	uc002qch.3	-	3	821	c.601G>A	c.(601-603)GAG>AAG	p.E201K	NLRP12_uc010eqw.2_5'Flank|NLRP12_uc002qci.3_Missense_Mutation_p.E201K|NLRP12_uc002qcj.3_Missense_Mutation_p.E201K|NLRP12_uc002qck.3_RNA|NLRP12_uc010eqx.2_Missense_Mutation_p.E201K	NM_144687	NP_653288	P59046	NAL12_HUMAN	NLR family, pyrin domain containing 12 isoform	201					negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of interleukin-1 secretion|negative regulation of interleukin-6 biosynthetic process|negative regulation of protein autophosphorylation|negative regulation of Toll signaling pathway|positive regulation of inflammatory response|positive regulation of interleukin-1 beta secretion|regulation of interleukin-18 biosynthetic process|release of cytoplasmic sequestered NF-kappaB	cytoplasm	ATP binding|caspase activator activity|protein binding			ovary(4)|upper_aerodigestive_tract(2)|lung(1)	7	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.026)		TCGTCTGGCTCAAAGAGGGTC	0.637			NA											40	106					0	0	0.013114	0	0
BRSK1	84446	broad.mit.edu	37	19	55814152	55814152	+	Silent	SNP	G	G	A			TCGA-05-4403-01A-01D-1265-08	TCGA-05-4403-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7e25ac0e-94e4-42f6-ae6f-89d0d21ce09f	a17b5d32-f570-4d2d-9e97-f8b01de1be9f	g.chr19:55814152G>A	uc002qkg.2	+	10	1222	c.945G>A	c.(943-945)CTG>CTA	p.L315L	BRSK1_uc002qkf.2_Silent_p.L331L|BRSK1_uc002qkh.2_Silent_p.L10L	NM_032430	NP_115806	Q8TDC3	BRSK1_HUMAN	BR serine/threonine kinase 1	315	UBA.				establishment of cell polarity|G2/M transition DNA damage checkpoint|neuron differentiation|response to UV	cell junction|cytoplasm|nucleus	magnesium ion binding|protein serine/threonine kinase activity			ovary(2)|stomach(1)|lung(1)|breast(1)|skin(1)	6		Renal(1328;0.245)	BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0474)		ACGGAGAGCTGGACCCCGACG	0.667			NA											29	96					0	0	0.004289	0	0
ZSCAN4	201516	broad.mit.edu	37	19	58190033	58190033	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4403-01A-01D-1265-08	TCGA-05-4403-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7e25ac0e-94e4-42f6-ae6f-89d0d21ce09f	a17b5d32-f570-4d2d-9e97-f8b01de1be9f	g.chr19:58190033C>A	uc002qpu.2	+	5	1759	c.1062C>A	c.(1060-1062)GAC>GAA	p.D354E		NM_152677	NP_689890	Q8NAM6	ZSCA4_HUMAN	zinc finger and SCAN domain containing 4	354	C2H2-type 2.				telomere maintenance via telomere lengthening|viral reproduction	nuclear chromosome, telomeric region	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1		Colorectal(82;0.000256)|all_neural(62;0.0577)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		AGATATCAGACCTACGGGTGC	0.443			NA											38	116					7.04047e-22	9.51163e-22	0.005524	1	0
PREPL	9581	broad.mit.edu	37	2	44565618	44565618	+	Missense_Mutation	SNP	T	T	C			TCGA-05-4403-01A-01D-1265-08	TCGA-05-4403-10A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7e25ac0e-94e4-42f6-ae6f-89d0d21ce09f	a17b5d32-f570-4d2d-9e97-f8b01de1be9f	g.chr2:44565618T>C	uc002ruf.2	-	7	1062	c.1027A>G	c.(1027-1029)ATG>GTG	p.M343V	PREPL_uc002rug.2_Missense_Mutation_p.M343V|PREPL_uc002ruh.2_Intron|PREPL_uc010fax.2_Missense_Mutation_p.M343V|PREPL_uc002rui.3_Missense_Mutation_p.M254V|PREPL_uc002ruj.1_Missense_Mutation_p.M254V|PREPL_uc002ruk.1_Missense_Mutation_p.M343V	NM_006036	NP_006027	Q4J6C6	PPCEL_HUMAN	prolyl endopeptidase-like isoform C	343					proteolysis	cytosol	serine-type endopeptidase activity			ovary(1)	1		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)				TTTCTCTTCATTGTAAAAAAT	0.358			NA											12	29					0	0	0.001855	0	0
CCDC85A	114800	broad.mit.edu	37	2	56420011	56420011	+	Nonsense_Mutation	SNP	A	A	T			TCGA-05-4403-01A-01D-1265-08	TCGA-05-4403-10A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7e25ac0e-94e4-42f6-ae6f-89d0d21ce09f	a17b5d32-f570-4d2d-9e97-f8b01de1be9f	g.chr2:56420011A>T	uc002rzn.2	+	2	1178	c.676A>T	c.(676-678)AAG>TAG	p.K226*		NM_001080433	NP_001073902	Q96PX6	CC85A_HUMAN	coiled-coil domain containing 85A	226	His-rich.									breast(3)|ovary(2)	5			LUSC - Lung squamous cell carcinoma(58;0.127)|Lung(47;0.132)			GGACCACCACAAGCACCACGC	0.692			NA											8	27					0	0	0.010729	0	0
SLC4A5	57835	broad.mit.edu	37	2	74492357	74492357	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4403-01A-01D-1265-08	TCGA-05-4403-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7e25ac0e-94e4-42f6-ae6f-89d0d21ce09f	a17b5d32-f570-4d2d-9e97-f8b01de1be9f	g.chr2:74492357C>T	uc002sko.1	-	4	438	c.436G>A	c.(436-438)GGC>AGC	p.G146S	SLC4A5_uc002skl.2_RNA|SLC4A5_uc002skn.2_Missense_Mutation_p.G146S|SLC4A5_uc010ffc.1_Missense_Mutation_p.G146S|SLC4A5_uc002skp.1_Missense_Mutation_p.G82S|SLC4A5_uc002sks.1_Missense_Mutation_p.G146S	NM_021196	NP_067019	Q9BY07	S4A5_HUMAN	sodium bicarbonate transporter 4 isoform a	146	Cytoplasmic (Potential).					apical plasma membrane|integral to membrane	inorganic anion exchanger activity|sodium:bicarbonate symporter activity			ovary(5)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	9						CAGCGTTCGCCGCCTTCCTCT	0.607			NA											30	126					0	0	0.007291	0	0
DPP10	57628	broad.mit.edu	37	2	116593780	116593780	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4403-01A-01D-1265-08	TCGA-05-4403-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7e25ac0e-94e4-42f6-ae6f-89d0d21ce09f	a17b5d32-f570-4d2d-9e97-f8b01de1be9f	g.chr2:116593780G>C	uc002tla.1	+	22	2455	c.1998G>C	c.(1996-1998)AAG>AAC	p.K666N	DPP10_uc002tlb.1_Missense_Mutation_p.K616N|DPP10_uc002tlc.1_Missense_Mutation_p.K662N|DPP10_uc002tle.2_Missense_Mutation_p.K670N|DPP10_uc002tlf.1_Missense_Mutation_p.K659N	NM_020868	NP_065919	Q8N608	DPP10_HUMAN	dipeptidyl peptidase 10 isoform long	666	Extracellular (Potential).				proteolysis	integral to membrane|membrane fraction	serine-type peptidase activity			ovary(5)|large_intestine(2)|skin(2)|breast(1)	10						CAGATGAAAAGCTTTTTAAAT	0.303			NA											7	35					0	0	0.004482	0	0
C2orf76	130355	broad.mit.edu	37	2	120097480	120097480	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4403-01A-01D-1265-08	TCGA-05-4403-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7e25ac0e-94e4-42f6-ae6f-89d0d21ce09f	a17b5d32-f570-4d2d-9e97-f8b01de1be9f	g.chr2:120097480C>T	uc002tls.2	-	3	597	c.56G>A	c.(55-57)CGC>CAC	p.R19H	C2orf76_uc010flf.1_Missense_Mutation_p.R19H|C2orf76_uc010yyg.1_RNA|C2orf76_uc002tlt.2_Missense_Mutation_p.R19H|C2orf76_uc002tlu.2_Missense_Mutation_p.R19H	NM_001017927	NP_001017927	Q3KRA6	CB076_HUMAN	hypothetical protein LOC130355	19											0						TTTGAAATTGCGATGTTCAAA	0.408			NA											11	94					0	0	0.001855	0	0
CNTNAP5	129684	broad.mit.edu	37	2	125555898	125555898	+	Splice_Site	SNP	G	G	T			TCGA-05-4403-01A-01D-1265-08	TCGA-05-4403-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7e25ac0e-94e4-42f6-ae6f-89d0d21ce09f	a17b5d32-f570-4d2d-9e97-f8b01de1be9f	g.chr2:125555898G>T	uc002tno.2	+	19	3578	c.3214_splice	c.e19+1	p.G1072_splice	CNTNAP5_uc010flu.2_Splice_Site_p.G1073_splice	NM_130773	NP_570129	Q8WYK1	CNTP5_HUMAN	contactin associated protein-like 5 precursor						cell adhesion|signal transduction	integral to membrane	receptor binding			ovary(10)	10				BRCA - Breast invasive adenocarcinoma(221;0.248)		TGCAAGAATGGTGAGTGTGAT	0.502			NA											15	42					0.000219431	0.000233146	0.00245	1	0
LOC150786	150786	broad.mit.edu	37	2	132120541	132120541	+	Silent	SNP	G	G	T			TCGA-05-4403-01A-01D-1265-08	TCGA-05-4403-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7e25ac0e-94e4-42f6-ae6f-89d0d21ce09f	a17b5d32-f570-4d2d-9e97-f8b01de1be9f	g.chr2:132120541G>T	uc002tsr.2	-	1	1191	c.753C>A	c.(751-753)GTC>GTA	p.V251V		NM_001077637	NP_001071105	Q53S08	Q53S08_HUMAN	RAB6C-like	251					protein transport|small GTPase mediated signal transduction		GTP binding				0				BRCA - Breast invasive adenocarcinoma(221;0.078)		ATCTCCACGAGACAGGCAGCA	0.378			NA											18	67					1.2644e-06	1.4095e-06	0.010504	1	0
CCDC148	130940	broad.mit.edu	37	2	159196812	159196812	+	Missense_Mutation	SNP	T	T	C			TCGA-05-4403-01A-01D-1265-08	TCGA-05-4403-10A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7e25ac0e-94e4-42f6-ae6f-89d0d21ce09f	a17b5d32-f570-4d2d-9e97-f8b01de1be9f	g.chr2:159196812T>C	uc002tzq.2	-	5	691	c.428A>G	c.(427-429)CAC>CGC	p.H143R	CCDC148_uc002tzr.2_Intron|CCDC148_uc010foh.2_Intron|CCDC148_uc010foi.1_Missense_Mutation_p.H90R|CCDC148_uc010foj.1_Intron|CCDC148_uc010fok.1_Missense_Mutation_p.H57R|CCDC148_uc002tzs.1_Missense_Mutation_p.H143R	NM_138803	NP_620158	Q8NFR7	CC148_HUMAN	coiled-coil domain containing 148	143										ovary(2)	2						CTGCAAAGTGTGATGCTGTCT	0.343			NA											18	52					0	0	0.007413	0	0
FAM124B	79843	broad.mit.edu	37	2	225266048	225266048	+	Missense_Mutation	SNP	A	A	T			TCGA-05-4403-01A-01D-1265-08	TCGA-05-4403-10A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7e25ac0e-94e4-42f6-ae6f-89d0d21ce09f	a17b5d32-f570-4d2d-9e97-f8b01de1be9f	g.chr2:225266048A>T	uc002vnx.2	-	1	664	c.438T>A	c.(436-438)TTT>TTA	p.F146L	FAM124B_uc002vnw.2_Missense_Mutation_p.F146L	NM_001122779	NP_001116251	Q9H5Z6	F124B_HUMAN	hypothetical protein LOC79843 isoform a	146							protein binding			ovary(2)	2		Renal(207;0.0112)|all_lung(227;0.0126)|Lung NSC(271;0.0161)|all_hematologic(139;0.138)		Epithelial(121;4.4e-10)|all cancers(144;2.02e-07)|Lung(261;0.00766)|LUSC - Lung squamous cell carcinoma(224;0.00825)		CATAGTTATCAAAACTGCAGT	0.517			NA											35	107					0	0	0.012213	0	0
IFT52	51098	broad.mit.edu	37	20	42265860	42265860	+	Nonsense_Mutation	SNP	G	G	T			TCGA-05-4403-01A-01D-1265-08	TCGA-05-4403-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7e25ac0e-94e4-42f6-ae6f-89d0d21ce09f	a17b5d32-f570-4d2d-9e97-f8b01de1be9f	g.chr20:42265860G>T	uc002xkw.2	+	12	1209	c.1087G>T	c.(1087-1089)GAG>TAG	p.E363*	IFT52_uc002xky.2_Nonsense_Mutation_p.E363*|IFT52_uc002xkx.2_RNA|IFT52_uc010ggn.2_Nonsense_Mutation_p.E339*|IFT52_uc002xkz.2_Nonsense_Mutation_p.E363*	NM_016004	NP_057088	Q9Y366	IFT52_HUMAN	intraflagellar transport 52 homolog	363						intraflagellar transport particle B|microtubule-based flagellum	protein C-terminus binding			ovary(2)	2		Myeloproliferative disorder(115;0.00452)	COAD - Colon adenocarcinoma(18;0.0031)			GTTCTCCTCTGAGAAGGCACG	0.318			NA											20	70					7.33532e-06	7.91749e-06	0.003954	1	0
TOX2	84969	broad.mit.edu	37	20	42574596	42574596	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4403-01A-01D-1265-08	TCGA-05-4403-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7e25ac0e-94e4-42f6-ae6f-89d0d21ce09f	a17b5d32-f570-4d2d-9e97-f8b01de1be9f	g.chr20:42574596G>T	uc002xlf.3	+	1	61	c.44G>T	c.(43-45)CGC>CTC	p.R15L	TOX2_uc010ggo.2_Intron|TOX2_uc002xle.3_Intron|TOX2_uc010ggp.2_Intron	NM_001098798	NP_001092268	Q96NM4	TOX2_HUMAN	TOX high mobility group box family member 2	15					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(1)	1		Myeloproliferative disorder(115;0.00452)	COAD - Colon adenocarcinoma(18;0.00189)			GCGTTCTCTCGCTGCCTGGGC	0.542			NA											16	42					4.35082e-09	5.10096e-09	0.010504	1	0
GNAS	2778	broad.mit.edu	37	20	57430246	57430246	+	Silent	SNP	G	G	A			TCGA-05-4403-01A-01D-1265-08	TCGA-05-4403-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7e25ac0e-94e4-42f6-ae6f-89d0d21ce09f	a17b5d32-f570-4d2d-9e97-f8b01de1be9f	g.chr20:57430246G>A	uc002xzw.2	+	1	2211	c.1926G>A	c.(1924-1926)GCG>GCA	p.A642A	GNAS_uc002xzt.2_Intron|GNAS_uc002xzu.3_Intron|GNAS_uc010gjq.2_Intron|GNAS_uc002xzv.2_RNA	NM_080425	NP_536350	P63092	GNAS2_HUMAN	GNAS complex locus XLas	Error:Variant_position_missing_in_P63092_after_alignment					activation of adenylate cyclase activity|cellular response to glucagon stimulus|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|intracellular transport|platelet activation|regulation of insulin secretion|sensory perception of smell|transmembrane transport|water transport	heterotrimeric G-protein complex|intrinsic to membrane|trans-Golgi network membrane	adenylate cyclase activity|GTP binding|GTPase activity|guanyl-nucleotide exchange factor activity|identical protein binding|signal transducer activity			pituitary(201)|thyroid(35)|ovary(15)|adrenal_gland(9)|liver(7)|large_intestine(5)|parathyroid(5)|kidney(5)|haematopoietic_and_lymphoid_tissue(3)|lung(2)|testis(1)|stomach(1)|small_intestine(1)|autonomic_ganglia(1)|pancreas(1)	292	all_lung(29;0.0104)		BRCA - Breast invasive adenocarcinoma(13;2.19e-08)|Colorectal(105;0.109)			TACCCCTGGCGGAGAAGCGCA	0.592	Colon(117;935 1597 6045 8307 46442)		NA	Mis		pituitary adenoma		McCune-Albright syndrome; pseudohypoparathyroidism|type IA		3-Methylglutaconic_Aciduria_and_Myelodysplasia|McCune-Albright_syndrome|Mazabraud_syndrome	TSP Lung(22;0.16)			3	16					0	0	0.004672	0	0
OSBPL2	9885	broad.mit.edu	37	20	60861678	60861678	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4403-01A-01D-1265-08	TCGA-05-4403-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7e25ac0e-94e4-42f6-ae6f-89d0d21ce09f	a17b5d32-f570-4d2d-9e97-f8b01de1be9f	g.chr20:60861678G>A	uc002yck.1	+	11	1238	c.1036G>A	c.(1036-1038)GAC>AAC	p.D346N	OSBPL2_uc002ycl.1_Missense_Mutation_p.D334N|OSBPL2_uc011aah.1_Missense_Mutation_p.D254N	NM_144498	NP_653081	Q9H1P3	OSBL2_HUMAN	oxysterol-binding protein-like protein 2 isoform	346					lipid transport		lipid binding			ovary(1)|central_nervous_system(1)	2	Breast(26;7.76e-09)		BRCA - Breast invasive adenocarcinoma(19;1.33e-06)			CGTGGCTGACGACGTGCCTGT	0.652			NA											46	186					0	0	0.00361	0	0
KRTAP24-1	643803	broad.mit.edu	37	21	31655088	31655088	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4403-01A-01D-1265-08	TCGA-05-4403-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7e25ac0e-94e4-42f6-ae6f-89d0d21ce09f	a17b5d32-f570-4d2d-9e97-f8b01de1be9f	g.chr21:31655088G>T	uc002ynv.2	-	1	189	c.163C>A	c.(163-165)CTC>ATC	p.L55I		NM_001085455	NP_001078924	Q3LI83	KR241_HUMAN	keratin associated protein 24-1	55						keratin filament	structural molecule activity				0						AGGAGCCAGAGATTTCCTTGG	0.498			NA											43	113					1.95508e-11	2.38824e-11	0.00361	1	0
AIRE	326	broad.mit.edu	37	21	45713696	45713696	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4403-01A-01D-1265-08	TCGA-05-4403-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7e25ac0e-94e4-42f6-ae6f-89d0d21ce09f	a17b5d32-f570-4d2d-9e97-f8b01de1be9f	g.chr21:45713696G>A	uc002zei.2	+	11	1430	c.1303G>A	c.(1303-1305)GGG>AGG	p.G435R	AIRE_uc010gpq.2_RNA|AIRE_uc002zej.2_Missense_Mutation_p.G238R|AIRE_uc010gpr.2_Missense_Mutation_p.G238R	NM_000383	NP_000374	O43918	AIRE_HUMAN	autoimmune regulator isoform 1	435	PHD-type 2.				positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	chromatin binding|histone binding|transcription regulatory region DNA binding|translation regulator activity|zinc ion binding			skin(1)	1				Colorectal(79;0.0806)		TGCGCGTTGCGGGGTGTGCGG	0.706			NA							Autoimmune_PolyEndocrinopathy_Candidiasis_Ectodermal_Dystrophy				19	54					0	0	0.00278	0	0
PRMT2	3275	broad.mit.edu	37	21	48068529	48068529	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4403-01A-01D-1265-08	TCGA-05-4403-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7e25ac0e-94e4-42f6-ae6f-89d0d21ce09f	a17b5d32-f570-4d2d-9e97-f8b01de1be9f	g.chr21:48068529G>A	uc002zjx.2	+	6	801	c.487G>A	c.(487-489)GCG>ACG	p.A163T	PRMT2_uc002zjw.2_Missense_Mutation_p.A163T|PRMT2_uc002zjy.2_Missense_Mutation_p.A163T|PRMT2_uc010gqm.2_Missense_Mutation_p.A163T|PRMT2_uc011aga.1_Missense_Mutation_p.A163T|PRMT2_uc011agb.1_Missense_Mutation_p.A163T|PRMT2_uc011agc.1_Missense_Mutation_p.A163T|PRMT2_uc002zjz.1_Missense_Mutation_p.A49T	NM_206962	NP_996845	P55345	ANM2_HUMAN	HMT1 hnRNP methyltransferase-like 1	163	Interaction with RB1 (By similarity).|Interaction with ESR1.				developmental cell growth|induction of apoptosis|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of NF-kappaB transcription factor activity|negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|regulation of androgen receptor signaling pathway	cytosol|nucleus	androgen receptor binding|estrogen receptor binding|histone-arginine N-methyltransferase activity|peroxisome proliferator activated receptor binding|progesterone receptor binding|protein homodimerization activity|retinoic acid receptor binding|signal transducer activity|thyroid hormone receptor binding|transcription coactivator activity			ovary(1)	1	Breast(49;0.247)	Lung NSC(3;0.245)		Epithelial(3;1.03e-07)|OV - Ovarian serous cystadenocarcinoma(3;4.68e-07)|all cancers(3;7.48e-07)|Colorectal(79;0.167)|Lung(125;0.203)|LUSC - Lung squamous cell carcinoma(216;0.23)|READ - Rectum adenocarcinoma(84;0.248)		GCGGCCTAGAGCGGTGAGTGG	0.587			NA											33	130					0	0	0.003271	0	0
RAB36	9609	broad.mit.edu	37	22	23495307	23495307	+	Silent	SNP	C	C	T			TCGA-05-4403-01A-01D-1265-08	TCGA-05-4403-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7e25ac0e-94e4-42f6-ae6f-89d0d21ce09f	a17b5d32-f570-4d2d-9e97-f8b01de1be9f	g.chr22:23495307C>T	uc002zwv.1	+	5	553	c.513C>T	c.(511-513)CCC>CCT	p.P171P	RAB36_uc010gtw.1_Silent_p.P149P	NM_004914	NP_004905	O95755	RAB36_HUMAN	RAB36, member RAS oncogene family	171					protein transport|small GTPase mediated signal transduction	Golgi membrane	GTP binding	p.P171S(1)		ovary(1)|central_nervous_system(1)	2	all_hematologic(9;0.0197)|Acute lymphoblastic leukemia(84;0.181)			READ - Rectum adenocarcinoma(21;0.155)		CTGGGATTCCCTATAGCCTCC	0.507			NA											49	191					0	0	0.00361	0	0
MMP11	4320	broad.mit.edu	37	22	24122621	24122621	+	Silent	SNP	C	C	T			TCGA-05-4403-01A-01D-1265-08	TCGA-05-4403-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7e25ac0e-94e4-42f6-ae6f-89d0d21ce09f	a17b5d32-f570-4d2d-9e97-f8b01de1be9f	g.chr22:24122621C>T	uc002zxx.2	+	3	436	c.414C>T	c.(412-414)AGC>AGT	p.S138S	MMP11_uc002zxy.2_RNA|MMP11_uc002zxz.2_5'Flank	NM_005940	NP_005931	P24347	MMP11_HUMAN	matrix metalloproteinase 11 preproprotein	138					collagen catabolic process|multicellular organismal development|proteolysis	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			skin(2)|large_intestine(1)	3		Medulloblastoma(6;9.86e-08)|all_neural(6;0.000318)				AGGTATGGAGCGATGTGACGC	0.627			NA											21	70					0	0	0.002299	0	0
MYO18B	84700	broad.mit.edu	37	22	26423541	26423541	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4403-01A-01D-1265-08	TCGA-05-4403-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7e25ac0e-94e4-42f6-ae6f-89d0d21ce09f	a17b5d32-f570-4d2d-9e97-f8b01de1be9f	g.chr22:26423541C>T	uc003abz.1	+	43	7851	c.7601C>T	c.(7600-7602)GCG>GTG	p.A2534V	MYO18B_uc003aca.1_Missense_Mutation_p.A2415V|MYO18B_uc010guy.1_Missense_Mutation_p.A2416V|MYO18B_uc010guz.1_Missense_Mutation_p.A2414V|MYO18B_uc011aka.1_Missense_Mutation_p.A1688V|MYO18B_uc011akb.1_Missense_Mutation_p.A2047V|MYO18B_uc010gva.1_Missense_Mutation_p.A517V|MYO18B_uc010gvb.1_RNA	NM_032608	NP_115997	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	2534						nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity			ovary(5)|central_nervous_system(3)|large_intestine(2)|breast(2)	12						CCACGACTTGCGGGTGACGGT	0.577			NA											15	41					0	0	0.00499	0	0
SELM	140606	broad.mit.edu	37	22	31501067	31501067	+	Silent	SNP	C	C	G			TCGA-05-4403-01A-01D-1265-08	TCGA-05-4403-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7e25ac0e-94e4-42f6-ae6f-89d0d21ce09f	a17b5d32-f570-4d2d-9e97-f8b01de1be9f	g.chr22:31501067C>G	uc011ali.1	-	6	387	c.327G>C	c.(325-327)GTG>GTC	p.V109V	SELM_uc011alj.1_RNA|INPP5J_uc010gwf.2_5'Flank	NM_080430	NP_536355	Q8WWX9	SELM_HUMAN	selenoprotein M precursor	109						endoplasmic reticulum|Golgi apparatus|nucleus|perinuclear region of cytoplasm					0						CGAGCTCCTGCACTAGCGCAT	0.692			NA											23	78					0	0	0.009535	0	0
TRANK1	9881	broad.mit.edu	37	3	36898996	36898996	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4403-01A-01D-1265-08	TCGA-05-4403-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7e25ac0e-94e4-42f6-ae6f-89d0d21ce09f	a17b5d32-f570-4d2d-9e97-f8b01de1be9f	g.chr3:36898996C>A	uc003cgj.2	-	3	737	c.435G>T	c.(433-435)TTG>TTT	p.L145F		NM_014831	NP_055646	O15050	TRNK1_HUMAN	lupus brain antigen 1	695					DNA repair		ATP binding|ATP-dependent DNA helicase activity|DNA binding			ovary(1)|central_nervous_system(1)	2						CCTGCTGAATCAAAACTGTGA	0.552			NA											12	56					4.3838e-07	4.96831e-07	0.001855	1	0
PTPN23	25930	broad.mit.edu	37	3	47451187	47451187	+	Silent	SNP	C	C	T			TCGA-05-4403-01A-01D-1265-08	TCGA-05-4403-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7e25ac0e-94e4-42f6-ae6f-89d0d21ce09f	a17b5d32-f570-4d2d-9e97-f8b01de1be9f	g.chr3:47451187C>T	uc003crf.1	+	19	2088	c.1992C>T	c.(1990-1992)GCC>GCT	p.A664A	PTPN23_uc011baw.1_Silent_p.A629A|PTPN23_uc011bax.1_RNA|PTPN23_uc011bay.1_Silent_p.A534A	NM_015466	NP_056281	Q9H3S7	PTN23_HUMAN	protein tyrosine phosphatase, non-receptor type	664					cilium morphogenesis	cilium|cytoplasmic membrane-bounded vesicle|microtubule basal body	protein tyrosine phosphatase activity			breast(1)|central_nervous_system(1)|skin(1)	3				BRCA - Breast invasive adenocarcinoma(193;0.000271)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		CGTATGAAGCCTATGAGGACC	0.632			NA											9	25					0	0	0.006214	0	0
MST1R	4486	broad.mit.edu	37	3	49927404	49927404	+	Silent	SNP	C	C	T			TCGA-05-4403-01A-01D-1265-08	TCGA-05-4403-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7e25ac0e-94e4-42f6-ae6f-89d0d21ce09f	a17b5d32-f570-4d2d-9e97-f8b01de1be9f	g.chr3:49927404C>T	uc003cxy.3	-	19	4164	c.3900G>A	c.(3898-3900)CTG>CTA	p.L1300L	MST1R_uc011bdc.1_Silent_p.L179L	NM_002447	NP_002438	Q04912	RON_HUMAN	macrophage stimulating 1 receptor precursor	1300	Cytoplasmic (Potential).|Protein kinase.				cellular component movement|defense response|multicellular organismal development|positive regulation of cell proliferation|single fertilization|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|macrophage colony-stimulating factor receptor activity|protein binding			ovary(5)|lung(1)	6				BRCA - Breast invasive adenocarcinoma(193;4.65e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.00553)|Kidney(197;0.00625)		GACCCTGGGCCAGGAAGTGGG	0.473			NA											28	73					0	0	0.012213	0	0
LRTM1	57408	broad.mit.edu	37	3	54958983	54958983	+	Silent	SNP	C	C	A			TCGA-05-4403-01A-01D-1265-08	TCGA-05-4403-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7e25ac0e-94e4-42f6-ae6f-89d0d21ce09f	a17b5d32-f570-4d2d-9e97-f8b01de1be9f	g.chr3:54958983C>A	uc003dhl.2	-	2	401	c.267G>T	c.(265-267)CTG>CTT	p.L89L	CACNA2D3_uc003dhf.2_Intron|CACNA2D3_uc003dhg.1_Intron|CACNA2D3_uc003dhh.1_Intron	NM_020678	NP_065729	Q9HBL6	LRTM1_HUMAN	leucine-rich repeats and transmembrane domains 1	89	Extracellular (Potential).|LRR 2.					integral to membrane					0				KIRC - Kidney renal clear cell carcinoma(284;0.00975)|Kidney(284;0.0112)|OV - Ovarian serous cystadenocarcinoma(275;0.0502)		CTCCAGGGGCCAGATTTGAAA	0.443			NA											10	45					5.50884e-06	5.97767e-06	0.001368	1	0
RYBP	23429	broad.mit.edu	37	3	72495721	72495721	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4403-01A-01D-1265-08	TCGA-05-4403-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7e25ac0e-94e4-42f6-ae6f-89d0d21ce09f	a17b5d32-f570-4d2d-9e97-f8b01de1be9f	g.chr3:72495721G>C	uc003dpe.2	-	1	171	c.54C>G	c.(52-54)AGC>AGG	p.S18R		NM_012234	NP_036366	Q8N488	RYBP_HUMAN	RING1 and YY1 binding protein	28	RanBP2-type.				apoptosis|histone H2A monoubiquitination|multicellular organismal development|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|nucleoplasm	DNA binding|protein binding|transcription corepressor activity|zinc ion binding				0		Prostate(10;0.00174)|Lung NSC(201;0.0659)|Myeloproliferative disorder(1037;0.204)		BRCA - Breast invasive adenocarcinoma(55;0.000197)|Epithelial(33;0.00068)|LUSC - Lung squamous cell carcinoma(21;0.00228)|Lung(16;0.00677)|KIRC - Kidney renal clear cell carcinoma(39;0.198)|Kidney(39;0.232)		AGGTGCAGACGCTACAATCCC	0.522			NA											9	27					0	0	0.006214	0	0
ROBO2	6092	broad.mit.edu	37	3	77666743	77666743	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4403-01A-01D-1265-08	TCGA-05-4403-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7e25ac0e-94e4-42f6-ae6f-89d0d21ce09f	a17b5d32-f570-4d2d-9e97-f8b01de1be9f	g.chr3:77666743G>T	uc003dpy.3	+	22	4016	c.3373G>T	c.(3373-3375)GAT>TAT	p.D1125Y	ROBO2_uc003dpz.2_Missense_Mutation_p.D1129Y|ROBO2_uc011bgj.1_RNA|ROBO2_uc011bgk.1_Missense_Mutation_p.D1129Y|ROBO2_uc003dqa.2_Missense_Mutation_p.D252Y	NM_002942	NP_002933	Q9HCK4	ROBO2_HUMAN	roundabout, axon guidance receptor, homolog 2	1125	Cytoplasmic (Potential).				apoptosis involved in luteolysis|axon midline choice point recognition|cellular response to hormone stimulus|homophilic cell adhesion|metanephros development|negative regulation of negative chemotaxis|negative regulation of synaptogenesis|olfactory bulb interneuron development|positive regulation of axonogenesis|retinal ganglion cell axon guidance|ureteric bud development	axolemma|cell surface|integral to membrane	axon guidance receptor activity|identical protein binding			lung(5)|skin(3)|ovary(1)|large_intestine(1)|liver(1)	11				Epithelial(33;0.00199)|LUSC - Lung squamous cell carcinoma(21;0.008)|BRCA - Breast invasive adenocarcinoma(55;0.00884)|Lung(72;0.0183)|KIRC - Kidney renal clear cell carcinoma(39;0.0832)|Kidney(39;0.103)		ACTGGAAGAAGATGATGATAG	0.473			NA											24	73					2.27525e-19	2.99453e-19	0.003954	1	0
TOPBP1	11073	broad.mit.edu	37	3	133362940	133362940	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4403-01A-01D-1265-08	TCGA-05-4403-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7e25ac0e-94e4-42f6-ae6f-89d0d21ce09f	a17b5d32-f570-4d2d-9e97-f8b01de1be9f	g.chr3:133362940G>A	uc003eps.2	-	11	1904	c.1772C>T	c.(1771-1773)GCG>GTG	p.A591V		NM_007027	NP_008958	Q92547	TOPB1_HUMAN	topoisomerase (DNA) II binding protein 1	591	BRCT 4.				DNA repair|response to ionizing radiation	microtubule organizing center|PML body|spindle pole	DNA binding|protein C-terminus binding			ovary(2)|kidney(2)|skin(1)|lung(1)|pancreas(1)	7						AGCATAATCCGCAACAGTTCT	0.413	Ovarian(21;193 658 4424 15423 17362)		NA						Other_conserved_DNA_damage_response_genes					7	37					0	0	0.00308	0	0
P2RY1	5028	broad.mit.edu	37	3	152553711	152553711	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4403-01A-01D-1265-08	TCGA-05-4403-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7e25ac0e-94e4-42f6-ae6f-89d0d21ce09f	a17b5d32-f570-4d2d-9e97-f8b01de1be9f	g.chr3:152553711C>T	uc003ezq.2	+	1	976	c.140C>T	c.(139-141)ACG>ATG	p.T47M		NM_002563	NP_002554	P47900	P2RY1_HUMAN	purinergic receptor P2Y1	47	Extracellular (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|platelet activation	integral to plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			lung(1)	1			LUSC - Lung squamous cell carcinoma(72;0.0628)|Lung(72;0.11)			TTGACCAAGACGGGCTTCCAG	0.597			NA											33	151					0	0	0.003755	0	0
C4orf23	152992	broad.mit.edu	37	4	8470028	8470028	+	Missense_Mutation	SNP	A	A	T			TCGA-05-4403-01A-01D-1265-08	TCGA-05-4403-10A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7e25ac0e-94e4-42f6-ae6f-89d0d21ce09f	a17b5d32-f570-4d2d-9e97-f8b01de1be9f	g.chr4:8470028A>T	uc003glg.1	+	9	1383	c.1195A>T	c.(1195-1197)ACA>TCA	p.T399S	C4orf23_uc003glf.1_Missense_Mutation_p.T387S|C4orf23_uc003glh.1_Missense_Mutation_p.T236S	NM_152544	NP_689757	Q8IYL2	TRM44_HUMAN	hypothetical protein LOC152992 isoform 2	628					tRNA processing	cytoplasm	methyltransferase activity|nucleic acid binding|zinc ion binding				0						GCAATTAAACACAAGAAGTTC	0.512			NA											10	145					0	0	0.006214	0	0
C1QTNF7	114905	broad.mit.edu	37	4	15444288	15444288	+	Silent	SNP	C	C	A			TCGA-05-4403-01A-01D-1265-08	TCGA-05-4403-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7e25ac0e-94e4-42f6-ae6f-89d0d21ce09f	a17b5d32-f570-4d2d-9e97-f8b01de1be9f	g.chr4:15444288C>A	uc011bxb.1	+	3	962	c.735C>A	c.(733-735)GTC>GTA	p.V245V	C1QTNF7_uc003gno.2_Silent_p.V252V|C1QTNF7_uc003gnp.2_Silent_p.V245V	NM_001135171	NP_001128643	Q9BXJ2	C1QT7_HUMAN	C1q and tumor necrosis factor related protein 7	245	C1q.					collagen					0						AAGATGAAGTCTGGCTGGAGA	0.493			NA											62	122					2.40655e-23	3.31714e-23	0.00361	1	0
FGFBP1	9982	broad.mit.edu	37	4	15938263	15938263	+	Translation_Start_Site	SNP	G	G	T			TCGA-05-4403-01A-01D-1265-08	TCGA-05-4403-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7e25ac0e-94e4-42f6-ae6f-89d0d21ce09f	a17b5d32-f570-4d2d-9e97-f8b01de1be9f	g.chr4:15938263G>T	uc003gom.2	-	2	111	c.-7C>A	c.(-9--5)AGCTG>AGATG			NM_005130	NP_005121	Q14512	FGFP1_HUMAN	fibroblast growth factor binding protein 1						cell-cell signaling|negative regulation of cell proliferation|signal transduction	extracellular space|plasma membrane	heparin binding				0						CATGGCTGCAGCTGGGCGTTC	0.557			NA											40	63					4.67007e-22	6.35129e-22	0.00874	1	0
SLC34A2	10568	broad.mit.edu	37	4	25674865	25674865	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4403-01A-01D-1265-08	TCGA-05-4403-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7e25ac0e-94e4-42f6-ae6f-89d0d21ce09f	a17b5d32-f570-4d2d-9e97-f8b01de1be9f	g.chr4:25674865C>A	uc003grr.2	+	10	1286	c.1205C>A	c.(1204-1206)ACC>AAC	p.T402N	SLC34A2_uc003grs.2_Missense_Mutation_p.T401N|SLC34A2_uc010iev.2_Missense_Mutation_p.T401N	NM_006424	NP_006415	O95436	NPT2B_HUMAN	solute carrier family 34 (sodium phosphate),	402	Cytoplasmic (Potential).				cellular phosphate ion homeostasis	apical plasma membrane|brush border membrane|integral to plasma membrane	phosphate binding|sodium ion binding|sodium-dependent phosphate transmembrane transporter activity|sodium:phosphate symporter activity			skin(3)|ovary(1)|kidney(1)	5		Breast(46;0.0503)				ATCAAGAAGACCATCAACACT	0.537			NA											26	51					1.37878e-21	1.85047e-21	0.00333	1	0
NDST3	9348	broad.mit.edu	37	4	119059262	119059262	+	Silent	SNP	C	C	T			TCGA-05-4403-01A-01D-1265-08	TCGA-05-4403-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7e25ac0e-94e4-42f6-ae6f-89d0d21ce09f	a17b5d32-f570-4d2d-9e97-f8b01de1be9f	g.chr4:119059262C>T	uc003ibx.2	+	5	1681	c.1278C>T	c.(1276-1278)GGC>GGT	p.G426G	NDST3_uc011cgf.1_Silent_p.G345G	NM_004784	NP_004775	O95803	NDST3_HUMAN	N-deacetylase/N-sulfotransferase (heparan	426	Lumenal (Potential).|Heparan sulfate N-deacetylase 3.					Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine N-sulfotransferase activity|hydrolase activity			large_intestine(1)	1						ACCATTCGGGCGTCTACCCTG	0.468			NA											11	98					0	0	0.001855	0	0
DCHS2	54798	broad.mit.edu	37	4	155241865	155241865	+	Silent	SNP	G	G	T			TCGA-05-4403-01A-01D-1265-08	TCGA-05-4403-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7e25ac0e-94e4-42f6-ae6f-89d0d21ce09f	a17b5d32-f570-4d2d-9e97-f8b01de1be9f	g.chr4:155241865G>T	uc003inw.2	-	14	3321	c.3321C>A	c.(3319-3321)ATC>ATA	p.I1107I		NM_017639	NP_060109	Q6V1P9	PCD23_HUMAN	dachsous 2 isoform 1	1107	Cadherin 9.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|pancreas(1)	4	all_hematologic(180;0.208)	Renal(120;0.0854)		LUSC - Lung squamous cell carcinoma(193;0.107)		ATGAGGGGTGGATGAGAAATG	0.443			NA											12	249					7.93312e-07	8.9412e-07	0.00245	1	0
RAPGEF2	9693	broad.mit.edu	37	4	160259617	160259617	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4403-01A-01D-1265-08	TCGA-05-4403-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7e25ac0e-94e4-42f6-ae6f-89d0d21ce09f	a17b5d32-f570-4d2d-9e97-f8b01de1be9f	g.chr4:160259617C>G	uc003iqg.3	+	12	2117	c.1807C>G	c.(1807-1809)CCT>GCT	p.P603A		NM_014247	NP_055062	Q9Y4G8	RPGF2_HUMAN	Rap guanine nucleotide exchange factor 2	603					cAMP-mediated signaling|MAPKKK cascade|small GTPase mediated signal transduction	integral to plasma membrane|intracellular	calcium ion binding|diacylglycerol binding|Rap GTPase activator activity|Rap guanyl-nucleotide exchange factor activity|signal transducer activity			lung(2)|upper_aerodigestive_tract(1)|skin(1)	4	all_hematologic(180;0.24)			COAD - Colon adenocarcinoma(41;0.0817)		CAGTGCTACTCCTGGTGAGTA	0.363			NA											31	148					0	0	0.003755	0	0
TLL1	7092	broad.mit.edu	37	4	166996110	166996110	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4403-01A-01D-1265-08	TCGA-05-4403-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7e25ac0e-94e4-42f6-ae6f-89d0d21ce09f	a17b5d32-f570-4d2d-9e97-f8b01de1be9f	g.chr4:166996110C>T	uc003irh.1	+	17	2916	c.2269C>T	c.(2269-2271)CGT>TGT	p.R757C	TLL1_uc011cjn.1_Missense_Mutation_p.R780C|TLL1_uc011cjo.1_Missense_Mutation_p.R581C	NM_012464	NP_036596	O43897	TLL1_HUMAN	tolloid-like 1 precursor	757	EGF-like 2; calcium-binding (Potential).				cell differentiation|proteolysis|skeletal system development	extracellular region	calcium ion binding|metalloendopeptidase activity|zinc ion binding			skin(3)|ovary(2)|breast(1)|central_nervous_system(1)	7	all_hematologic(180;0.221)	Melanoma(52;0.0315)|Prostate(90;0.0405)		GBM - Glioblastoma multiforme(119;0.103)		GTGTCAATGCCGTAATGGATT	0.408			NA											28	123					0	0	0.00632	0	0
HEATR7B2	133558	broad.mit.edu	37	5	41045927	41045927	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4403-01A-01D-1265-08	TCGA-05-4403-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7e25ac0e-94e4-42f6-ae6f-89d0d21ce09f	a17b5d32-f570-4d2d-9e97-f8b01de1be9f	g.chr5:41045927C>A	uc003jmj.3	-	18	2247	c.1757G>T	c.(1756-1758)AGT>ATT	p.S586I	HEATR7B2_uc003jmi.3_Missense_Mutation_p.S141I	NM_173489	NP_775760	Q7Z745	HTRB2_HUMAN	HEAT repeat family member 7B2	586	HEAT 7.						binding			ovary(6)|central_nervous_system(2)	8						GGCCACATCACTGATCTTCCA	0.423			NA											28	105					1.06801e-11	1.3125e-11	0.009535	1	0
MCCC2	64087	broad.mit.edu	37	5	70898367	70898367	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4403-01A-01D-1265-08	TCGA-05-4403-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7e25ac0e-94e4-42f6-ae6f-89d0d21ce09f	a17b5d32-f570-4d2d-9e97-f8b01de1be9f	g.chr5:70898367G>A	uc003kbs.3	+	5	556	c.418G>A	c.(418-420)GTC>ATC	p.V140I	MCCC2_uc010iyv.1_Missense_Mutation_p.V140I|MCCC2_uc003kbt.3_RNA|MCCC2_uc003kbu.1_Missense_Mutation_p.V9I	NM_022132	NP_071415	Q9HCC0	MCCB_HUMAN	methylcrotonoyl-Coenzyme A carboxylase 2 (beta)	140	Carboxyltransferase.				leucine catabolic process	mitochondrial inner membrane|mitochondrial matrix	ATP binding|methylcrotonoyl-CoA carboxylase activity			ovary(1)	1		Lung NSC(167;0.000697)|Prostate(74;0.0107)|Ovarian(174;0.0175)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;2.04e-54)	Biotin(DB00121)	TGATGCCACCGTCAAAGGAGG	0.413			NA											30	123					0	0	0.003755	0	0
KIF4B	285643	broad.mit.edu	37	5	154396120	154396120	+	Missense_Mutation	SNP	A	A	T			TCGA-05-4403-01A-01D-1265-08	TCGA-05-4403-10A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7e25ac0e-94e4-42f6-ae6f-89d0d21ce09f	a17b5d32-f570-4d2d-9e97-f8b01de1be9f	g.chr5:154396120A>T	uc010jih.1	+	1	2861	c.2701A>T	c.(2701-2703)ATG>TTG	p.M901L		NM_001099293	NP_001092763	Q2VIQ3	KIF4B_HUMAN	kinesin family member 4B	901	Interaction with PRC1 (By similarity).|Potential.				axon guidance|blood coagulation|microtubule-based movement	cytosol|microtubule|nuclear matrix	ATP binding|DNA binding|microtubule motor activity			ovary(1)	1	Renal(175;0.00488)	Medulloblastoma(196;0.0523)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)			CATGCAGAAGATGCTATTTGA	0.438			NA											21	78					0	0	0.00278	0	0
GABRA6	2559	broad.mit.edu	37	5	161128622	161128622	+	Missense_Mutation	SNP	T	T	C			TCGA-05-4403-01A-01D-1265-08	TCGA-05-4403-10A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7e25ac0e-94e4-42f6-ae6f-89d0d21ce09f	a17b5d32-f570-4d2d-9e97-f8b01de1be9f	g.chr5:161128622T>C	uc003lyu.2	+	9	1543	c.1205T>C	c.(1204-1206)GTC>GCC	p.V402A	GABRA6_uc003lyv.2_Missense_Mutation_p.V173A	NM_000811	NP_000802	Q16445	GBRA6_HUMAN	gamma-aminobutyric acid A receptor, alpha 6	402	Cytoplasmic (Probable).				gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity			ovary(7)|skin(3)|large_intestine(1)|central_nervous_system(1)	12	Renal(175;0.00259)	Medulloblastoma(196;0.0208)|all_neural(177;0.0672)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)		Alprazolam(DB00404)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	TCAACACCTGTCACACCCCCA	0.473			NA								TCGA Ovarian(5;0.080)			16	52					0	0	0.003954	0	0
GMPR	2766	broad.mit.edu	37	6	16254908	16254908	+	Missense_Mutation	SNP	A	A	T			TCGA-05-4403-01A-01D-1265-08	TCGA-05-4403-10A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7e25ac0e-94e4-42f6-ae6f-89d0d21ce09f	a17b5d32-f570-4d2d-9e97-f8b01de1be9f	g.chr6:16254908A>T	uc003nbs.2	+	4	521	c.407A>T	c.(406-408)GAA>GTA	p.E136V		NM_006877	NP_006868	P36959	GMPR1_HUMAN	guanosine monophosphate reductase	136					nucleotide metabolic process|purine base metabolic process|purine-containing compound salvage|response to cold	cytosol	GMP reductase activity|metal ion binding			ovary(1)	1	Breast(50;0.0427)|Ovarian(93;0.103)	all_hematologic(90;0.0895)				GGGTATTCAGAACATTTTGTG	0.443			NA											52	195					0	0	0.00361	0	0
TTBK1	84630	broad.mit.edu	37	6	43250827	43250827	+	Silent	SNP	G	G	T			TCGA-05-4403-01A-01D-1265-08	TCGA-05-4403-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7e25ac0e-94e4-42f6-ae6f-89d0d21ce09f	a17b5d32-f570-4d2d-9e97-f8b01de1be9f	g.chr6:43250827G>T	uc003ouq.1	+	14	2628	c.2349G>T	c.(2347-2349)GGG>GGT	p.G783G		NM_032538	NP_115927	Q5TCY1	TTBK1_HUMAN	tau tubulin kinase 1	783						cell junction|cytoplasm|nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			lung(4)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	9			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0125)|OV - Ovarian serous cystadenocarcinoma(102;0.0399)			AGGTGCTGGGGCCTCGTAGTG	0.448			NA											3	5					0.004672	0.00483801	0.004672	1	0
GCLC	2729	broad.mit.edu	37	6	53380938	53380938	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4403-01A-01D-1265-08	TCGA-05-4403-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7e25ac0e-94e4-42f6-ae6f-89d0d21ce09f	a17b5d32-f570-4d2d-9e97-f8b01de1be9f	g.chr6:53380938C>A	uc003pbw.1	-	4	917	c.529G>T	c.(529-531)GAT>TAT	p.D177Y	GCLC_uc003pbx.2_Missense_Mutation_p.D177Y	NM_001498	NP_001489	P48506	GSH1_HUMAN	glutamate-cysteine ligase, catalytic subunit	177					anti-apoptosis|cell redox homeostasis|cysteine metabolic process|glutamate metabolic process|glutathione biosynthetic process|negative regulation of transcription, DNA-dependent|regulation of blood vessel size|response to heat|response to hormone stimulus|response to oxidative stress|xenobiotic metabolic process	cytosol	ADP binding|ATP binding|coenzyme binding|glutamate binding|glutamate-cysteine ligase activity|magnesium ion binding			ovary(1)|central_nervous_system(1)	2	Lung NSC(77;0.0137)				L-Cysteine(DB00151)|L-Glutamic Acid(DB00142)	ATTGCTTCATCTGGAAAGAAG	0.473			NA											26	66					6.32553e-13	7.96548e-13	0.004656	1	0
FAM83B	222584	broad.mit.edu	37	6	54735197	54735197	+	Silent	SNP	A	A	T			TCGA-05-4403-01A-01D-1265-08	TCGA-05-4403-10A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7e25ac0e-94e4-42f6-ae6f-89d0d21ce09f	a17b5d32-f570-4d2d-9e97-f8b01de1be9f	g.chr6:54735197A>T	uc003pck.2	+	2	269	c.153A>T	c.(151-153)CGA>CGT	p.R51R		NM_001010872	NP_001010872	Q5T0W9	FA83B_HUMAN	hypothetical protein LOC222584	51										ovary(6)	6	Lung NSC(77;0.0178)|Renal(3;0.122)					TCCAGGAACGAGTTTCAGACT	0.388			NA											25	99					0	0	0.004656	0	0
HTR1E	3354	broad.mit.edu	37	6	87726137	87726137	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4403-01A-01D-1265-08	TCGA-05-4403-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7e25ac0e-94e4-42f6-ae6f-89d0d21ce09f	a17b5d32-f570-4d2d-9e97-f8b01de1be9f	g.chr6:87726137G>A	uc003pli.2	+	2	1788	c.1085G>A	c.(1084-1086)CGA>CAA	p.R362Q		NM_000865	NP_000856	P28566	5HT1E_HUMAN	5-hydroxytryptamine (serotonin) receptor 1E	362	Cytoplasmic (By similarity).				G-protein signaling, coupled to cyclic nucleotide second messenger|synaptic transmission	integral to plasma membrane	protein binding|serotonin binding|serotonin receptor activity			ovary(2)|skin(1)	3		all_cancers(76;7.11e-06)|Acute lymphoblastic leukemia(125;1.2e-09)|Prostate(29;3.51e-09)|all_hematologic(105;7.43e-06)|all_epithelial(107;0.00819)		BRCA - Breast invasive adenocarcinoma(108;0.055)	Eletriptan(DB00216)	ATTAGATGCCGAGAGCATACT	0.413			NA											28	101					0	0	0.007291	0	0
GABRR1	2569	broad.mit.edu	37	6	89907932	89907932	+	Missense_Mutation	SNP	A	A	G			TCGA-05-4403-01A-01D-1265-08	TCGA-05-4403-10A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7e25ac0e-94e4-42f6-ae6f-89d0d21ce09f	a17b5d32-f570-4d2d-9e97-f8b01de1be9f	g.chr6:89907932A>G	uc003pna.2	-	5	834	c.379T>C	c.(379-381)TAC>CAC	p.Y127H	GABRR1_uc011dzv.1_Missense_Mutation_p.Y104H	NM_002042	NP_002033	P24046	GBRR1_HUMAN	gamma-aminobutyric acid (GABA) receptor, rho 1	127	Extracellular (Probable).				gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			pancreas(1)	1		all_cancers(76;9.49e-09)|Prostate(29;1.16e-10)|Acute lymphoblastic leukemia(125;1.46e-10)|all_hematologic(105;7.74e-07)|all_epithelial(107;0.000114)		BRCA - Breast invasive adenocarcinoma(108;0.00917)	Picrotoxin(DB00466)	TCCTTCCAGTAGTGCCTCAGG	0.537			NA											94	324					0	0	0.00361	0	0
DSE	29940	broad.mit.edu	37	6	116757636	116757636	+	Missense_Mutation	SNP	A	A	G	rs145999978		TCGA-05-4403-01A-01D-1265-08	TCGA-05-4403-10A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7e25ac0e-94e4-42f6-ae6f-89d0d21ce09f	a17b5d32-f570-4d2d-9e97-f8b01de1be9f	g.chr6:116757636A>G	uc003pws.2	+	6	2199	c.2005A>G	c.(2005-2007)ATA>GTA	p.I669V	DSE_uc011ebg.1_Missense_Mutation_p.I688V|DSE_uc003pwt.2_Missense_Mutation_p.I669V|DSE_uc003pwu.2_Missense_Mutation_p.I336V	NM_001080976	NP_001074445	Q9UL01	DSE_HUMAN	dermatan sulfate epimerase precursor	669					dermatan sulfate biosynthetic process	endoplasmic reticulum|Golgi apparatus|integral to membrane	chondroitin-glucuronate 5-epimerase activity			ovary(1)	1		all_cancers(87;0.00019)|all_epithelial(87;0.000416)|Ovarian(999;0.133)|Colorectal(196;0.234)		Epithelial(106;0.00915)|OV - Ovarian serous cystadenocarcinoma(136;0.0149)|GBM - Glioblastoma multiforme(226;0.0189)|all cancers(137;0.0262)		AGGGCCATCTATAGATGTTCA	0.517			NA											20	76					0	0	0.012319	0	0
SLC35F1	222553	broad.mit.edu	37	6	118556737	118556737	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4403-01A-01D-1265-08	TCGA-05-4403-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7e25ac0e-94e4-42f6-ae6f-89d0d21ce09f	a17b5d32-f570-4d2d-9e97-f8b01de1be9f	g.chr6:118556737G>A	uc003pxx.3	+	3	616	c.415G>A	c.(415-417)GAC>AAC	p.D139N		NM_001029858	NP_001025029	Q5T1Q4	S35F1_HUMAN	solute carrier family 35, member F1	139	Helical; (Potential).				transport	integral to membrane				breast(1)	1				GBM - Glioblastoma multiforme(226;0.217)		GGGACTCATAGACCTGGAAGC	0.423			NA											21	75					0	0	0.002299	0	0
ENPP3	5169	broad.mit.edu	37	6	132006597	132006597	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4403-01A-01D-1265-08	TCGA-05-4403-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7e25ac0e-94e4-42f6-ae6f-89d0d21ce09f	a17b5d32-f570-4d2d-9e97-f8b01de1be9f	g.chr6:132006597G>T	uc003qcu.3	+	14	1561	c.1214G>T	c.(1213-1215)CGC>CTC	p.R405L	ENPP3_uc010kfq.2_RNA|ENPP3_uc003qcv.2_Missense_Mutation_p.R405L	NM_005021	NP_005012	O14638	ENPP3_HUMAN	ectonucleotide pyrophosphatase/phosphodiesterase	405	Extracellular (Potential).|Phosphodiesterase.				immune response|nucleoside triphosphate catabolic process|phosphate metabolic process	extracellular region|integral to plasma membrane|perinuclear region of cytoplasm	metal ion binding|nucleic acid binding|nucleoside-triphosphate diphosphatase activity|nucleotide diphosphatase activity|phosphodiesterase I activity|polysaccharide binding|scavenger receptor activity			ovary(3)|skin(1)	4	Breast(56;0.0753)			GBM - Glioblastoma multiforme(226;0.0252)|OV - Ovarian serous cystadenocarcinoma(155;0.0511)		CCTGCCCCCCGCATCCGAGCT	0.378			NA											51	181					4.6707e-30	6.6631e-30	0.00361	1	0
TNFAIP3	7128	broad.mit.edu	37	6	138199659	138199659	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4403-01A-01D-1265-08	TCGA-05-4403-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7e25ac0e-94e4-42f6-ae6f-89d0d21ce09f	a17b5d32-f570-4d2d-9e97-f8b01de1be9f	g.chr6:138199659C>A	uc003qhr.2	+	7	1143	c.1077C>A	c.(1075-1077)AAC>AAA	p.N359K	TNFAIP3_uc003qhs.2_Missense_Mutation_p.N359K	NM_006290	NP_006281	P21580	TNAP3_HUMAN	tumor necrosis factor, alpha-induced protein 3	359					anti-apoptosis|apoptosis|B-1 B cell homeostasis|negative regulation of B cell activation|negative regulation of bone resorption|negative regulation of CD40 signaling pathway|negative regulation of endothelial cell apoptosis|negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of inflammatory response|negative regulation of interleukin-2 production|negative regulation of interleukin-6 production|negative regulation of NF-kappaB transcription factor activity|negative regulation of osteoclast proliferation|negative regulation of protein ubiquitination|negative regulation of smooth muscle cell proliferation|negative regulation of toll-like receptor 2 signaling pathway|negative regulation of toll-like receptor 3 signaling pathway|negative regulation of tumor necrosis factor production|negative regulation of type I interferon production|positive regulation of protein catabolic process|protein K48-linked ubiquitination|protein K63-linked deubiquitination|protein oligomerization|regulation of defense response to virus by host|regulation of germinal center formation|regulation of vascular wound healing|tolerance induction to lipopolysaccharide	centrosome|cytosol|nucleus	caspase inhibitor activity|DNA binding|protease binding|protein self-association|ubiquitin binding|ubiquitin thiolesterase activity|ubiquitin-protein ligase activity|ubiquitin-specific protease activity|zinc ion binding	p.0?(22)		haematopoietic_and_lymphoid_tissue(133)|lung(3)|ovary(1)	137	Breast(32;0.135)|Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.000849)|OV - Ovarian serous cystadenocarcinoma(155;0.00468)		GGCAGGAAAACAGCGAGCAGG	0.478	GBM(130;153 1739 22295 28918 47987)		NA	D|N|F		marginal zone B-cell lymphomas|Hodgkin's lymphoma|primary mediastinal B cell lymphoma								6	97					0.00448238	0.00466534	0.004482	1	0
GET4	51608	broad.mit.edu	37	7	931971	931971	+	Missense_Mutation	SNP	A	A	T			TCGA-05-4403-01A-01D-1265-08	TCGA-05-4403-10A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7e25ac0e-94e4-42f6-ae6f-89d0d21ce09f	a17b5d32-f570-4d2d-9e97-f8b01de1be9f	g.chr7:931971A>T	uc003sjl.1	+	6	754	c.662A>T	c.(661-663)CAG>CTG	p.Q221L	GET4_uc003sjj.1_RNA	NM_015949	NP_057033	Q7L5D6	GET4_HUMAN	hypothetical protein LOC51608	221					tail-anchored membrane protein insertion into ER membrane|transport	BAT3 complex	protein binding				0						ACGTACACCCAGAAGCACCCG	0.552			NA											35	119					0	0	0.004878	0	0
SNX13	23161	broad.mit.edu	37	7	17885294	17885294	+	Silent	SNP	T	T	A			TCGA-05-4403-01A-01D-1265-08	TCGA-05-4403-10A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7e25ac0e-94e4-42f6-ae6f-89d0d21ce09f	a17b5d32-f570-4d2d-9e97-f8b01de1be9f	g.chr7:17885294T>A	uc003stw.1	-	12	1302	c.1089A>T	c.(1087-1089)GCA>GCT	p.A363A	SNX13_uc003stv.2_Silent_p.A363A|SNX13_uc010kuc.2_Silent_p.A160A			Q9Y5W8	SNX13_HUMAN	SubName: Full=Putative uncharacterized protein SNX13; SubName: Full=Sorting nexin 13, isoform CRA_g;	363					cell communication|intracellular protein transport|negative regulation of signal transduction|positive regulation of GTPase activity	early endosome membrane	phosphatidylinositol binding|signal transducer activity			central_nervous_system(2)|kidney(1)	3	Lung NSC(10;0.0261)|all_lung(11;0.0521)					CAAAGTTTGCTGCAAGTTTCA	0.313			NA											6	9					0	0	0.001168	0	0
ADCY1	107	broad.mit.edu	37	7	45614391	45614391	+	Silent	SNP	G	G	C			TCGA-05-4403-01A-01D-1265-08	TCGA-05-4403-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7e25ac0e-94e4-42f6-ae6f-89d0d21ce09f	a17b5d32-f570-4d2d-9e97-f8b01de1be9f	g.chr7:45614391G>C	uc003tne.3	+	1	267	c.249G>C	c.(247-249)GCG>GCC	p.A83A	ADCY1_uc003tnd.2_Intron	NM_021116	NP_066939	Q08828	ADCY1_HUMAN	adenylate cyclase 1	83	Helical; (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|calmodulin binding|metal ion binding			ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	6					Adenosine(DB00640)|Adenosine monophosphate(DB00131)|Adenosine triphosphate(DB00171)	TGCTgggcgcgccggggcccg	0.622			NA											6	13					0	0	0.001984	0	0
AUTS2	26053	broad.mit.edu	37	7	70254903	70254903	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4403-01A-01D-1265-08	TCGA-05-4403-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7e25ac0e-94e4-42f6-ae6f-89d0d21ce09f	a17b5d32-f570-4d2d-9e97-f8b01de1be9f	g.chr7:70254903C>T	uc003tvw.3	+	19	3444	c.2701C>T	c.(2701-2703)CGC>TGC	p.R901C	AUTS2_uc003tvx.3_Missense_Mutation_p.R877C|AUTS2_uc011keg.1_Missense_Mutation_p.R353C	NM_015570	NP_056385	Q8WXX7	AUTS2_HUMAN	autism susceptibility candidate 2 isoform 1	901										ovary(2)|central_nervous_system(1)	3		all_cancers(73;0.0264)|all_epithelial(88;0.0198)|Lung NSC(55;0.0599)|all_lung(88;0.093)		LUSC - Lung squamous cell carcinoma(90;0.082)|Lung(90;0.186)		CTCGGAATCCCGCAAGGACCT	0.647			NA											8	37					0	0	0.008291	0	0
TMEM168	64418	broad.mit.edu	37	7	112424368	112424368	+	Silent	SNP	A	A	G			TCGA-05-4403-01A-01D-1265-08	TCGA-05-4403-10A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7e25ac0e-94e4-42f6-ae6f-89d0d21ce09f	a17b5d32-f570-4d2d-9e97-f8b01de1be9f	g.chr7:112424368A>G	uc003vgn.2	-	2	905	c.513T>C	c.(511-513)ACT>ACC	p.T171T	TMEM168_uc010lju.2_Silent_p.T171T|TMEM168_uc011kmr.1_Intron	NM_022484	NP_071929	Q9H0V1	TM168_HUMAN	transmembrane protein 168	171						integral to membrane|transport vesicle				ovary(1)|central_nervous_system(1)	2						CCACCAACATAGTTGTGCTGG	0.423			NA											23	47					0	0	0.00278	0	0
MET	4233	broad.mit.edu	37	7	116380037	116380037	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4403-01A-01D-1265-08	TCGA-05-4403-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7e25ac0e-94e4-42f6-ae6f-89d0d21ce09f	a17b5d32-f570-4d2d-9e97-f8b01de1be9f	g.chr7:116380037C>T	uc003vij.2	+	4	1613	c.1426C>T	c.(1426-1428)CAT>TAT	p.H476Y	MET_uc010lkh.2_Missense_Mutation_p.H476Y|MET_uc011knc.1_Missense_Mutation_p.H476Y|MET_uc011knd.1_Missense_Mutation_p.H476Y|MET_uc011kne.1_Missense_Mutation_p.H476Y|MET_uc011knf.1_Missense_Mutation_p.H476Y|MET_uc011kng.1_Missense_Mutation_p.H476Y|MET_uc011knh.1_Missense_Mutation_p.H476Y|MET_uc011kni.1_Missense_Mutation_p.H476Y|MET_uc011knj.1_Missense_Mutation_p.H46Y|MET_uc011kna.1_Missense_Mutation_p.H476Y|MET_uc011knb.1_Missense_Mutation_p.H476Y	NM_000245	NP_000236	P08581	MET_HUMAN	met proto-oncogene isoform b precursor	476	Extracellular (Potential).|Sema.				axon guidance|cell proliferation	basal plasma membrane|integral to plasma membrane	ATP binding|hepatocyte growth factor receptor activity|protein binding			upper_aerodigestive_tract(63)|lung(41)|kidney(18)|NS(10)|ovary(5)|thyroid(4)|central_nervous_system(4)|stomach(3)|liver(3)|pleura(2)|large_intestine(2)|breast(2)|testis(1)|skin(1)	159	all_cancers(3;1.25e-07)|all_epithelial(6;4.07e-08)|Lung NSC(10;0.00108)|all_lung(10;0.00125)	Ovarian(593;0.133)	GBM - Glioblastoma multiforme(2;2.31e-07)|all cancers(2;0.000419)|STAD - Stomach adenocarcinoma(10;0.000512)			ATCAACCCCTCATGTGAATTT	0.398			NA	Mis		papillary renal|head-neck squamous cell 	papillary renal			Hereditary_Papillary_Renal_Carcinoma_(type_1)				35	191					0	0	0.00623	0	0
PIP	5304	broad.mit.edu	37	7	142836664	142836664	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4403-01A-01D-1265-08	TCGA-05-4403-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7e25ac0e-94e4-42f6-ae6f-89d0d21ce09f	a17b5d32-f570-4d2d-9e97-f8b01de1be9f	g.chr7:142836664C>A	uc003wcf.1	+	4	406	c.370C>A	c.(370-372)CCT>ACT	p.P124T		NM_002652	NP_002643	P12273	PIP_HUMAN	prolactin-induced protein precursor	124						extracellular region	actin binding			ovary(1)	1	Melanoma(164;0.059)	Ovarian(593;2.82e-05)|Breast(660;0.012)		BRCA - Breast invasive adenocarcinoma(188;0.0026)|LUSC - Lung squamous cell carcinoma(290;0.0733)|Lung(243;0.08)		AGGCATCTGCCCTGATGATGC	0.468			NA											66	272					1.37693e-34	1.97813e-34	0.00361	1	0
ANGPT2	285	broad.mit.edu	37	8	6378821	6378821	+	Missense_Mutation	SNP	A	A	T			TCGA-05-4403-01A-01D-1265-08	TCGA-05-4403-10A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7e25ac0e-94e4-42f6-ae6f-89d0d21ce09f	a17b5d32-f570-4d2d-9e97-f8b01de1be9f	g.chr8:6378821A>T	uc003wqj.3	-	4	1006	c.677T>A	c.(676-678)ATC>AAC	p.I226N	MCPH1_uc003wqi.2_Intron|ANGPT2_uc003wqk.3_Missense_Mutation_p.I226N|ANGPT2_uc010lri.2_Missense_Mutation_p.I174N|ANGPT2_uc003wql.3_Missense_Mutation_p.I226N	NM_001147	NP_001138	O15123	ANGP2_HUMAN	angiopoietin 2 isoform a precursor	226	Potential.				angiogenesis|blood coagulation|leukocyte migration|negative regulation of blood vessel endothelial cell migration|negative regulation of positive chemotaxis|Tie receptor signaling pathway	extracellular space	metal ion binding|receptor tyrosine kinase binding			upper_aerodigestive_tract(1)	1		Hepatocellular(245;0.0663)		Colorectal(4;0.0142)|READ - Rectum adenocarcinoma(4;0.19)|COAD - Colon adenocarcinoma(4;0.226)		TTCTTCAATGATGGAATTTTG	0.373			NA											32	116					0	0	0.012213	0	0
SGCZ	137868	broad.mit.edu	37	8	13948039	13948039	+	Silent	SNP	G	G	A			TCGA-05-4403-01A-01D-1265-08	TCGA-05-4403-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7e25ac0e-94e4-42f6-ae6f-89d0d21ce09f	a17b5d32-f570-4d2d-9e97-f8b01de1be9f	g.chr8:13948039G>A	uc003wwq.2	-	8	1512	c.852C>T	c.(850-852)TGC>TGT	p.C284C	SGCZ_uc010lss.2_Silent_p.C237C	NM_139167	NP_631906	Q96LD1	SGCZ_HUMAN	sarcoglycan zeta	271	Extracellular (Potential).				cytoskeleton organization	cytoplasm|cytoskeleton|integral to membrane|sarcolemma				ovary(2)|central_nervous_system(1)	3				all cancers(2;0.000643)|Colorectal(111;0.00674)|COAD - Colon adenocarcinoma(73;0.0193)|GBM - Glioblastoma multiforme(2;0.026)		TGGGGCAGACGCAGAGTTCAT	0.483			NA											19	81					0	0	0.008871	0	0
C8orf41	80185	broad.mit.edu	37	8	33361291	33361291	+	Missense_Mutation	SNP	T	T	C			TCGA-05-4403-01A-01D-1265-08	TCGA-05-4403-10A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7e25ac0e-94e4-42f6-ae6f-89d0d21ce09f	a17b5d32-f570-4d2d-9e97-f8b01de1be9f	g.chr8:33361291T>C	uc003xjl.3	-	4	1615	c.1090A>G	c.(1090-1092)AGA>GGA	p.R364G	C8orf41_uc003xjk.3_Missense_Mutation_p.R333G|C8orf41_uc010lvv.2_Intron|C8orf41_uc003xjm.3_Missense_Mutation_p.R364G|C8orf41_uc003xjn.1_Missense_Mutation_p.R364G	NM_025115	NP_079391	Q6NXR4	CH041_HUMAN	hypothetical protein LOC80185	364							binding				0				KIRC - Kidney renal clear cell carcinoma(67;0.0923)|Kidney(114;0.111)		GGCAGGTTTCTTGCGTAGGTC	0.418			NA											9	30					0	0	0.006214	0	0
POLB	5423	broad.mit.edu	37	8	42196548	42196548	+	Missense_Mutation	SNP	A	A	G			TCGA-05-4403-01A-01D-1265-08	TCGA-05-4403-10A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7e25ac0e-94e4-42f6-ae6f-89d0d21ce09f	a17b5d32-f570-4d2d-9e97-f8b01de1be9f	g.chr8:42196548A>G	uc003xoz.1	+	2	193	c.80A>G	c.(79-81)AAG>AGG	p.K27R	POLB_uc003xpa.1_Missense_Mutation_p.K27R|POLB_uc011lcs.1_Intron	NM_002690	NP_002681	P06746	DPOLB_HUMAN	DNA-directed DNA polymerase beta	27					DNA-dependent DNA replication	cytoplasm|nucleoplasm|spindle microtubule	DNA-(apurinic or apyrimidinic site) lyase activity|DNA-directed DNA polymerase activity|enzyme binding|metal ion binding|microtubule binding			ovary(1)|breast(1)	2	all_cancers(6;1.42e-24)|all_epithelial(6;1.02e-25)|all_lung(13;2.58e-12)|Lung NSC(13;4.24e-11)|Ovarian(28;0.00769)|Prostate(17;0.0119)|Colorectal(14;0.1)|Lung SC(25;0.211)	all_lung(54;0.00671)|Lung NSC(58;0.0184)|Esophageal squamous(32;0.131)|Hepatocellular(245;0.133)|Renal(179;0.151)	BRCA - Breast invasive adenocarcinoma(8;3.18e-11)|Lung(22;0.00467)|OV - Ovarian serous cystadenocarcinoma(14;0.00523)|LUSC - Lung squamous cell carcinoma(45;0.024)		Cytarabine(DB00987)	AACTTTGAGAAGAACGTGAGC	0.483			NA						DNA_polymerases_(catalytic_subunits)					12	39					0	0	0.003163	0	0
CHRNA6	8973	broad.mit.edu	37	8	42612132	42612132	+	Missense_Mutation	SNP	T	T	G			TCGA-05-4403-01A-01D-1265-08	TCGA-05-4403-10A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7e25ac0e-94e4-42f6-ae6f-89d0d21ce09f	a17b5d32-f570-4d2d-9e97-f8b01de1be9f	g.chr8:42612132T>G	uc003xpj.2	-	4	359	c.313A>C	c.(313-315)ATT>CTT	p.I105L	CHRNA6_uc011lcw.1_Missense_Mutation_p.I90L	NM_004198	NP_004189	Q15825	ACHA6_HUMAN	cholinergic receptor, nicotinic, alpha 6	105	Extracellular.					cell junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity				0	all_lung(13;3.33e-12)|Lung NSC(13;9.17e-11)|Ovarian(28;0.01)|Prostate(17;0.0119)|Lung SC(25;0.184)	all_lung(54;0.00439)|Lung NSC(58;0.0124)|Esophageal squamous(32;0.131)|Hepatocellular(245;0.133)|Renal(179;0.151)	Lung(22;0.0252)|LUSC - Lung squamous cell carcinoma(45;0.0869)			AGAGTCTCAATGCCATCATAT	0.373			NA											35	155					0	0	0.005524	0	0
PSKH2	85481	broad.mit.edu	37	8	87076326	87076326	+	Silent	SNP	G	G	A			TCGA-05-4403-01A-01D-1265-08	TCGA-05-4403-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7e25ac0e-94e4-42f6-ae6f-89d0d21ce09f	a17b5d32-f570-4d2d-9e97-f8b01de1be9f	g.chr8:87076326G>A	uc011lfy.1	-	2	720	c.720C>T	c.(718-720)ACC>ACT	p.T240T		NM_033126	NP_149117	Q96QS6	KPSH2_HUMAN	protein serine kinase H2	240	Protein kinase.						ATP binding|protein serine/threonine kinase activity			stomach(2)|lung(2)|ovary(1)	5			STAD - Stomach adenocarcinoma(118;0.129)			CCACTGCACTGGTATAAGGCT	0.473			NA											27	98					0	0	0.00632	0	0
UTP23	84294	broad.mit.edu	37	8	117783936	117783936	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4403-01A-01D-1265-08	TCGA-05-4403-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7e25ac0e-94e4-42f6-ae6f-89d0d21ce09f	a17b5d32-f570-4d2d-9e97-f8b01de1be9f	g.chr8:117783936C>T	uc003yoc.2	+	3	706	c.605C>T	c.(604-606)CCC>CTC	p.P202L		NM_032334	NP_115710	Q9BRU9	UTP23_HUMAN	UTP23, small subunit (SSU) processome component,	202					rRNA processing	nucleolus					0						ATAAGTGGTCCCAATCCTCTT	0.363			NA											18	51					0	0	0.007413	0	0
TRMT12	55039	broad.mit.edu	37	8	125464025	125464025	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4403-01A-01D-1265-08	TCGA-05-4403-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7e25ac0e-94e4-42f6-ae6f-89d0d21ce09f	a17b5d32-f570-4d2d-9e97-f8b01de1be9f	g.chr8:125464025G>A	uc003yra.3	+	1	978	c.857G>A	c.(856-858)CGG>CAG	p.R286Q		NM_017956	NP_060426	Q53H54	TYW2_HUMAN	homolog of yeast tRNA methyltransferase 12	286					tRNA processing		methyltransferase activity			upper_aerodigestive_tract(1)	1	Ovarian(258;0.00438)|all_neural(195;0.0779)|Hepatocellular(40;0.108)		STAD - Stomach adenocarcinoma(47;0.00288)			GTAGCAGATCGGTGCCAAATA	0.483			NA											54	182					0	0	0.00361	0	0
RFX3	5991	broad.mit.edu	37	9	3257077	3257077	+	Silent	SNP	C	C	A			TCGA-05-4403-01A-01D-1265-08	TCGA-05-4403-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7e25ac0e-94e4-42f6-ae6f-89d0d21ce09f	a17b5d32-f570-4d2d-9e97-f8b01de1be9f	g.chr9:3257077C>A	uc003zhr.2	-	15	2040	c.1728G>T	c.(1726-1728)GTG>GTT	p.V576V	RFX3_uc010mhd.2_Silent_p.V576V|RFX3_uc003zhs.1_Silent_p.V576V	NM_134428	NP_602304	P48380	RFX3_HUMAN	regulatory factor X3 isoform b	576					cell maturation|ciliary cell motility|cilium assembly|cilium movement involved in determination of left/right asymmetry|endocrine pancreas development|negative regulation of transcription, DNA-dependent|positive regulation of transcription from RNA polymerase II promoter|positive regulation of type B pancreatic cell development|regulation of insulin secretion	nuclear chromatin	protein binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding			ovary(2)|central_nervous_system(1)|pancreas(1)	4				GBM - Glioblastoma multiforme(50;0.00124)|Lung(2;0.0337)		CTTGCATCATCACATTGTCAA	0.473			NA											59	96					1.80625e-27	2.55886e-27	0.00361	1	0
RANBP6	26953	broad.mit.edu	37	9	6013371	6013371	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4403-01A-01D-1265-08	TCGA-05-4403-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7e25ac0e-94e4-42f6-ae6f-89d0d21ce09f	a17b5d32-f570-4d2d-9e97-f8b01de1be9f	g.chr9:6013371C>T	uc003zjr.2	-	1	2248	c.2237G>A	c.(2236-2238)GGC>GAC	p.G746D	RANBP6_uc011lmf.1_Missense_Mutation_p.G394D|RANBP6_uc003zjs.2_Missense_Mutation_p.G334D	NM_012416	NP_036548	O60518	RNBP6_HUMAN	RAN binding protein 6	746					protein transport	cytoplasm|nucleus	binding			ovary(3)	3		Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.00522)|Lung(218;0.101)		ATACTCTGGGCCACGAATTCT	0.423			NA											49	49					0	0	0.00361	0	0
TRPM3	80036	broad.mit.edu	37	9	73225623	73225623	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4403-01A-01D-1265-08	TCGA-05-4403-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7e25ac0e-94e4-42f6-ae6f-89d0d21ce09f	a17b5d32-f570-4d2d-9e97-f8b01de1be9f	g.chr9:73225623C>T	uc004aid.2	-	18	2777	c.2533G>A	c.(2533-2535)GAT>AAT	p.D845N	TRPM3_uc004ahu.2_Missense_Mutation_p.D675N|TRPM3_uc004ahv.2_Missense_Mutation_p.D647N|TRPM3_uc004ahw.2_Missense_Mutation_p.D717N|TRPM3_uc004ahx.2_Missense_Mutation_p.D704N|TRPM3_uc004ahy.2_Missense_Mutation_p.D707N|TRPM3_uc004ahz.2_Missense_Mutation_p.D694N|TRPM3_uc004aia.2_Missense_Mutation_p.D692N|TRPM3_uc004aib.2_Missense_Mutation_p.D682N|TRPM3_uc004aic.2_Missense_Mutation_p.D845N	NM_001007471	NP_001007472	Q9HCF6	TRPM3_HUMAN	transient receptor potential cation channel,	870	Extracellular (Potential).					integral to membrane	calcium channel activity			ovary(3)|pancreas(2)|central_nervous_system(2)|skin(2)	9						TCCTCTTCATCCTTCTTCCTG	0.398			NA											26	141					0	0	0.008361	0	0
IL3RA	3563	broad.mit.edu	37	X	1471347	1471347	+	Silent	SNP	C	C	T			TCGA-05-4403-01A-01D-1265-08	TCGA-05-4403-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7e25ac0e-94e4-42f6-ae6f-89d0d21ce09f	a17b5d32-f570-4d2d-9e97-f8b01de1be9f	g.chrX:1471347C>T	uc004cps.2	+	6	913	c.564C>T	c.(562-564)AGC>AGT	p.S188S	IL3RA_uc011mhd.1_Silent_p.S110S	NM_002183	NP_002174	P26951	IL3RA_HUMAN	interleukin 3 receptor, alpha precursor	188	Extracellular (Potential).					integral to membrane|plasma membrane	interleukin-3 receptor activity			skin(2)|lung(1)	3		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)			Sargramostim(DB00020)	GGGGCAGGAGCGCAGCCTTCG	0.552			NA											4	146					0	0	0.009096	0	0
NHS	4810	broad.mit.edu	37	X	17745407	17745407	+	Missense_Mutation	SNP	T	T	C			TCGA-05-4403-01A-01D-1265-08	TCGA-05-4403-10A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7e25ac0e-94e4-42f6-ae6f-89d0d21ce09f	a17b5d32-f570-4d2d-9e97-f8b01de1be9f	g.chrX:17745407T>C	uc004cxx.2	+	6	3456	c.3118T>C	c.(3118-3120)TCC>CCC	p.S1040P	NHS_uc011mix.1_Missense_Mutation_p.S1061P|NHS_uc004cxy.2_Missense_Mutation_p.S884P|NHS_uc004cxz.2_Missense_Mutation_p.S863P|NHS_uc004cya.2_Missense_Mutation_p.S763P	NM_198270	NP_938011	Q6T4R5	NHS_HUMAN	Nance-Horan syndrome protein isoform 1	1040						nucleus				skin(3)|ovary(2)|breast(1)|central_nervous_system(1)	7	Hepatocellular(33;0.183)					AGAAAGAAAATCCTCACTACA	0.423			NA											3	109					0	0	0.009096	0	0
FAM47B	170062	broad.mit.edu	37	X	34961502	34961502	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4403-01A-01D-1265-08	TCGA-05-4403-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7e25ac0e-94e4-42f6-ae6f-89d0d21ce09f	a17b5d32-f570-4d2d-9e97-f8b01de1be9f	g.chrX:34961502G>C	uc004ddi.1	+	1	572	c.554G>C	c.(553-555)GGG>GCG	p.G185A		NM_152631	NP_689844	Q8NA70	FA47B_HUMAN	hypothetical protein LOC170062	185										ovary(3)|breast(1)	4						TATCCCTGTGGGGAATCCTGC	0.642			NA											6	17					0	0	0.004482	0	0
CXorf22	170063	broad.mit.edu	37	X	35974187	35974187	+	Silent	SNP	A	A	G			TCGA-05-4403-01A-01D-1265-08	TCGA-05-4403-10A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7e25ac0e-94e4-42f6-ae6f-89d0d21ce09f	a17b5d32-f570-4d2d-9e97-f8b01de1be9f	g.chrX:35974187A>G	uc004ddj.2	+	8	1343	c.1284A>G	c.(1282-1284)GAA>GAG	p.E428E	CXorf22_uc010ngv.2_RNA	NM_152632	NP_689845	Q6ZTR5	CX022_HUMAN	hypothetical protein LOC170063	428										large_intestine(1)|lung(1)|ovary(1)	3						TCATGGGTGAACGTTCAGAAA	0.363			NA											23	46					0	0	0.00278	0	0
RBM10	8241	broad.mit.edu	37	X	47032557	47032557	+	Nonsense_Mutation	SNP	C	C	T			TCGA-05-4403-01A-01D-1265-08	TCGA-05-4403-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7e25ac0e-94e4-42f6-ae6f-89d0d21ce09f	a17b5d32-f570-4d2d-9e97-f8b01de1be9f	g.chrX:47032557C>T	uc004dhf.2	+	5	842	c.463C>T	c.(463-465)CAA>TAA	p.Q155*	RBM10_uc004dhe.1_Nonsense_Mutation_p.Q145*|RBM10_uc004dhg.2_Nonsense_Mutation_p.Q78*|RBM10_uc004dhh.2_Nonsense_Mutation_p.Q155*|RBM10_uc010nhq.2_Nonsense_Mutation_p.Q78*|RBM10_uc004dhi.2_Nonsense_Mutation_p.Q220*	NM_005676	NP_005667	P98175	RBM10_HUMAN	RNA binding motif protein 10 isoform 1	155	RRM 1.				mRNA processing|RNA splicing	chromatin remodeling complex	nucleotide binding|RNA binding|zinc ion binding			ovary(1)|large_intestine(1)|prostate(1)|breast(1)|pancreas(1)	5						GCACGGCGTGCAAGCACGGGA	0.602	Melanoma(171;120 2705 19495 39241)		NA											9	28					0	0	0.008291	0	0
RGAG1	57529	broad.mit.edu	37	X	109693957	109693957	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4403-01A-01D-1265-08	TCGA-05-4403-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7e25ac0e-94e4-42f6-ae6f-89d0d21ce09f	a17b5d32-f570-4d2d-9e97-f8b01de1be9f	g.chrX:109693957G>C	uc004eor.1	+	3	358	c.112G>C	c.(112-114)GAC>CAC	p.D38H	RGAG1_uc011msr.1_Missense_Mutation_p.D38H	NM_020769	NP_065820	Q8NET4	RGAG1_HUMAN	retrotransposon gag domain containing 1	38										lung(2)|upper_aerodigestive_tract(1)|ovary(1)	4						GACCAGAGCAGACGTACAGAT	0.463			NA									OREG0019909	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	81	119					0	0	0.00361	0	0
RGAG1	57529	broad.mit.edu	37	X	109696066	109696066	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4403-01A-01D-1265-08	TCGA-05-4403-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7e25ac0e-94e4-42f6-ae6f-89d0d21ce09f	a17b5d32-f570-4d2d-9e97-f8b01de1be9f	g.chrX:109696066G>T	uc004eor.1	+	3	2467	c.2221G>T	c.(2221-2223)GCT>TCT	p.A741S	RGAG1_uc011msr.1_Missense_Mutation_p.A741S	NM_020769	NP_065820	Q8NET4	RGAG1_HUMAN	retrotransposon gag domain containing 1	741										lung(2)|upper_aerodigestive_tract(1)|ovary(1)	4						GTCCATGACCGCTGGAGGGAT	0.512			NA											37	68					1.49673e-21	1.99564e-21	0.00623	1	0
MCF2	4168	broad.mit.edu	37	X	138687138	138687138	+	Nonsense_Mutation	SNP	A	A	C			TCGA-05-4403-01A-01D-1265-08	TCGA-05-4403-10A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7e25ac0e-94e4-42f6-ae6f-89d0d21ce09f	a17b5d32-f570-4d2d-9e97-f8b01de1be9f	g.chrX:138687138A>C	uc004fau.2	-	14	1857	c.1563T>G	c.(1561-1563)TAT>TAG	p.Y521*	MCF2_uc004fav.2_Nonsense_Mutation_p.Y537*|MCF2_uc011mwl.1_Nonsense_Mutation_p.Y498*|MCF2_uc010nsh.1_Nonsense_Mutation_p.Y521*|MCF2_uc011mwm.1_Nonsense_Mutation_p.Y482*|MCF2_uc011mwn.1_Nonsense_Mutation_p.Y666*|MCF2_uc004faw.2_Nonsense_Mutation_p.Y581*|MCF2_uc011mwo.1_Nonsense_Mutation_p.Y597*	NM_005369	NP_005360	P10911	MCF2_HUMAN	MCF.2 cell line derived transforming sequence	521	DH.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytoskeleton|cytosol|membrane|membrane fraction	protein binding|Rho guanyl-nucleotide exchange factor activity			lung(1)|pleura(1)	2	Acute lymphoblastic leukemia(192;0.000127)					TCTCCGCTCTATAACCCTACC	0.353			NA											20	23					0	0	0.010504	0	0
UTY	7404	broad.mit.edu	37	Y	15467250	15467250	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4403-01A-01D-1265-08	TCGA-05-4403-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7e25ac0e-94e4-42f6-ae6f-89d0d21ce09f	a17b5d32-f570-4d2d-9e97-f8b01de1be9f	g.chrY:15467250C>G	uc004fsx.1	-	15	2408	c.1403G>C	c.(1402-1404)CGA>CCA	p.R468P	UTY_uc004fsw.1_Missense_Mutation_p.R131P|UTY_uc010nwx.1_5'UTR|UTY_uc004fsy.2_Missense_Mutation_p.R468P|UTY_uc004fsz.2_Missense_Mutation_p.R468P	NM_007125	NP_009056	O14607	UTY_HUMAN	tetratricopeptide repeat protein isoform 3	468					chromatin modification	nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen				0						TCCAGTAGTTCGTACCTGAGC	0.383	Colon(103;1740 2135 40732 45171)		NA											5	25					0	0	0.004482	0	0
RIMBP2	23504	broad.mit.edu	37	12	130912881	130912881	+	Frame_Shift_Del	DEL	G	G	-			TCGA-05-4403-01A-01D-1265-08	TCGA-05-4403-10A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7e25ac0e-94e4-42f6-ae6f-89d0d21ce09f	a17b5d32-f570-4d2d-9e97-f8b01de1be9f	g.chr12:130912881delG	uc001uil.2	-	12	2368	c.2204delC	c.(2203-2205)CCGfs	p.P735fs		NM_015347	NP_056162	O15034	RIMB2_HUMAN	RIM-binding protein 2	735						cell junction|synapse				upper_aerodigestive_tract(3)|ovary(3)|large_intestine(2)|central_nervous_system(2)|pancreas(1)	11	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.213)		OV - Ovarian serous cystadenocarcinoma(86;4.29e-06)|all cancers(50;4.56e-05)|Epithelial(86;5.41e-05)		GCAACAGTGCGGCTGGGGGCC	0.587			NA											27	100	---	---	---	---	NA	NA	NA	NA	NA
DHODH	1723	broad.mit.edu	37	16	72050929	72050931	+	In_Frame_Del	DEL	ATT	ATT	-			TCGA-05-4403-01A-01D-1265-08	TCGA-05-4403-10A-01D-1265-08	ATT	ATT	-	-	ATT	ATT	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7e25ac0e-94e4-42f6-ae6f-89d0d21ce09f	a17b5d32-f570-4d2d-9e97-f8b01de1be9f	g.chr16:72050929_72050931delATT	uc002fbp.2	+	4	462_464	c.441_443delATT	c.(439-444)GGATTT>GGT	p.F148del	DHODH_uc010cgk.2_RNA	NM_001361	NP_001352	Q02127	PYRD_HUMAN	dihydroorotate dehydrogenase precursor	148	Mitochondrial intermembrane (By similarity).|Substrate binding.				'de novo' pyrimidine base biosynthetic process|pyrimidine nucleoside biosynthetic process|UMP biosynthetic process	integral to membrane|mitochondrial inner membrane	dihydroorotate oxidase activity				0		Ovarian(137;0.125)			Atovaquone(DB01117)|Leflunomide(DB01097)	GCAGGTATGGATTTAACAGTCAC	0.512			NA											22	79	---	---	---	---	NA	NA	NA	NA	NA
HSDL1	83693	broad.mit.edu	37	16	84164817	84164818	+	Frame_Shift_Ins	INS	-	-	T			TCGA-05-4403-01A-01D-1265-08	TCGA-05-4403-10A-01D-1265-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7e25ac0e-94e4-42f6-ae6f-89d0d21ce09f	a17b5d32-f570-4d2d-9e97-f8b01de1be9f	g.chr16:84164817_84164818insT	uc002fhk.2	-	3	293_294	c.109_110insA	c.(109-111)AGCfs	p.S37fs	HSDL1_uc010vnv.1_Frame_Shift_Ins_p.S37fs	NM_031463	NP_113651	Q3SXM5	HSDL1_HUMAN	hydroxysteroid dehydrogenase like 1 isoform a	37	Required for mitochondria translocation.					mitochondrion	oxidoreductase activity|protein binding				0						GACAGTGATGCTTTTTCTGGCC	0.49			NA											36	153	---	---	---	---	NA	NA	NA	NA	NA
ZNF831	128611	broad.mit.edu	37	20	57766823	57766823	+	Frame_Shift_Del	DEL	C	C	-			TCGA-05-4403-01A-01D-1265-08	TCGA-05-4403-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7e25ac0e-94e4-42f6-ae6f-89d0d21ce09f	a17b5d32-f570-4d2d-9e97-f8b01de1be9f	g.chr20:57766823delC	uc002yan.2	+	1	749	c.749delC	c.(748-750)GCCfs	p.A250fs		NM_178457	NP_848552	Q5JPB2	ZN831_HUMAN	zinc finger protein 831	250						intracellular	nucleic acid binding|zinc ion binding			skin(13)|ovary(1)	14	all_lung(29;0.0085)					TCTCCGGGTGCCCACGTGCCC	0.667			NA											35	121	---	---	---	---	NA	NA	NA	NA	NA
HS3ST5	222537	broad.mit.edu	37	6	114379073	114379075	+	In_Frame_Del	DEL	TCA	TCA	-			TCGA-05-4403-01A-01D-1265-08	TCGA-05-4403-10A-01D-1265-08	TCA	TCA	-	-	TCA	TCA	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7e25ac0e-94e4-42f6-ae6f-89d0d21ce09f	a17b5d32-f570-4d2d-9e97-f8b01de1be9f	g.chr6:114379073_114379075delTCA	uc003pwg.3	-	2	419_421	c.387_389delTGA	c.(385-390)GATGAG>GAG	p.D129del	uc003pwf.2_Intron|HS3ST5_uc003pwh.3_In_Frame_Del_p.D129del	NM_153612	NP_705840	Q8IZT8	HS3S5_HUMAN	heparan sulfate (glucosamine)	129	Lumenal (Potential).				heparan sulfate proteoglycan biosynthetic process, enzymatic modification|negative regulation of coagulation|protein sulfation|regulation of virion penetration into host cell	Golgi membrane|integral to membrane	3'-phosphoadenosine 5'-phosphosulfate binding|[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity|protein binding			ovary(1)|pancreas(1)	2		all_cancers(87;0.0587)|Colorectal(196;0.0676)|all_epithelial(87;0.154)		OV - Ovarian serous cystadenocarcinoma(136;0.00937)|all cancers(137;0.0117)|Epithelial(106;0.0274)|GBM - Glioblastoma multiforme(226;0.143)		ACCATAATTCTCATCATTATCAA	0.429			NA											39	256	---	---	---	---	NA	NA	NA	NA	NA
TAAR5	9038	broad.mit.edu	37	6	132910150	132910151	+	Frame_Shift_Ins	INS	-	-	A			TCGA-05-4403-01A-01D-1265-08	TCGA-05-4403-10A-01D-1265-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7e25ac0e-94e4-42f6-ae6f-89d0d21ce09f	a17b5d32-f570-4d2d-9e97-f8b01de1be9f	g.chr6:132910150_132910151insA	uc003qdk.2	-	1	727_728	c.675_676insT	c.(673-678)GTTGCTfs	p.V225fs		NM_003967	NP_003958	O14804	TAAR5_HUMAN	trace amine associated receptor 5	225_226	Cytoplasmic (Potential).				synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity			skin(1)	1	Breast(56;0.112)			OV - Ovarian serous cystadenocarcinoma(155;0.00604)|GBM - Glioblastoma multiforme(226;0.015)		TGTCTGGTAGCAACCACAAAGA	0.5			NA											17	104	---	---	---	---	NA	NA	NA	NA	NA
SYNE1	23345	broad.mit.edu	37	6	152557353	152557353	+	Frame_Shift_Del	DEL	C	C	-			TCGA-05-4403-01A-01D-1265-08	TCGA-05-4403-10A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7e25ac0e-94e4-42f6-ae6f-89d0d21ce09f	a17b5d32-f570-4d2d-9e97-f8b01de1be9f	g.chr6:152557353delC	uc010kiw.2	-	110	20887	c.20285delG	c.(20284-20286)TGCfs	p.C6762fs	SYNE1_uc010kiv.2_Frame_Shift_Del_p.C1286fs|SYNE1_uc003qos.3_Frame_Shift_Del_p.C1286fs|SYNE1_uc003qot.3_Frame_Shift_Del_p.C6691fs|SYNE1_uc003qou.3_Frame_Shift_Del_p.C6762fs	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	6762	Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		TAGATCTGAGCAGCTGATGGA	0.343			NA								HNSCC(10;0.0054)			42	123	---	---	---	---	NA	NA	NA	NA	NA
MYST3	7994	broad.mit.edu	37	8	41798420	41798422	+	In_Frame_Del	DEL	CTC	CTC	-			TCGA-05-4403-01A-01D-1265-08	TCGA-05-4403-10A-01D-1265-08	CTC	CTC	-	-	CTC	CTC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	7e25ac0e-94e4-42f6-ae6f-89d0d21ce09f	a17b5d32-f570-4d2d-9e97-f8b01de1be9f	g.chr8:41798420_41798422delCTC	uc010lxb.2	-	16	3521_3523	c.2977_2979delGAG	c.(2977-2979)GAGdel	p.E993del	MYST3_uc010lxc.2_In_Frame_Del_p.E993del|MYST3_uc003xon.3_In_Frame_Del_p.E993del	NM_001099412	NP_001092882	Q92794	MYST3_HUMAN	MYST histone acetyltransferase (monocytic	993	Poly-Glu.				histone H3 acetylation|myeloid cell differentiation|negative regulation of transcription, DNA-dependent|nucleosome assembly|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	MOZ/MORF histone acetyltransferase complex|nucleosome	DNA binding|histone acetyltransferase activity|transcription coactivator activity|transcription factor binding|zinc ion binding			ovary(4)|pancreas(1)|central_nervous_system(1)|skin(1)	7	all_epithelial(6;1.12e-27)|all_lung(13;3.94e-12)|Lung NSC(13;6.54e-11)|Ovarian(28;0.00744)|Prostate(17;0.0119)|Colorectal(14;0.0221)|Lung SC(25;0.211)	all_lung(54;0.000294)|Lung NSC(58;0.00105)|Hepatocellular(245;0.0524)|Esophageal squamous(32;0.0954)|Renal(179;0.0983)	Epithelial(1;2.82e-19)|all cancers(1;1.15e-16)|BRCA - Breast invasive adenocarcinoma(8;9.17e-11)|OV - Ovarian serous cystadenocarcinoma(14;9.4e-05)|Colorectal(10;0.000728)|Lung(22;0.00153)|LUSC - Lung squamous cell carcinoma(45;0.00741)|COAD - Colon adenocarcinoma(11;0.0171)			GGCTTTCCGGCTCCTCCTCCTCC	0.567			NA											8	285	---	---	---	---	NA	NA	NA	NA	NA