Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	ACHILLES_Top_Genes	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
PLEKHN1	84069	broad.mit.edu	37	1	905907	905907	+	Missense_Mutation	SNP	A	A	T			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr1:905907A>T	uc001ace.2	+	4	372	c.337A>T	c.(337-339)AGC>TGC	p.S113C	PLEKHN1_uc001acd.2_Missense_Mutation_p.S113C|PLEKHN1_uc001acf.2_Missense_Mutation_p.S113C	NM_032129	NP_115505	Q494U1	PKHN1_HUMAN	pleckstrin homology domain containing, family N	113	PH 1.										0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		UCEC - Uterine corpus endometrioid carcinoma (11;0.00459)|Epithelial(90;4.31e-38)|OV - Ovarian serous cystadenocarcinoma(86;5.93e-23)|Colorectal(212;0.000159)|COAD - Colon adenocarcinoma(227;0.000193)|BRCA - Breast invasive adenocarcinoma(365;0.00095)|Kidney(185;0.0023)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0342)|Lung(427;0.199)		GCAGGATGTCAGCGACTGCTA	0.672			NA											29	54					0	0	0.009535	0	0
UBE2J2	118424	broad.mit.edu	37	1	1192480	1192480	+	Silent	SNP	C	C	A			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr1:1192480C>A	uc001adn.2	-	5	616	c.306G>T	c.(304-306)CCG>CCT	p.P102P	UBE2J2_uc001adm.2_Silent_p.P67P|UBE2J2_uc001ado.2_Silent_p.P118P|UBE2J2_uc001adp.2_Silent_p.P102P|UBE2J2_uc001adq.2_Silent_p.P50P|UBE2J2_uc001adr.2_Silent_p.P50P|UBE2J2_uc001ads.2_Silent_p.P50P	NM_194458	NP_919440	Q8N2K1	UB2J2_HUMAN	ubiquitin conjugating enzyme E2, J2 isoform 3	102	Cytoplasmic (Potential).				response to unfolded protein	endoplasmic reticulum membrane|integral to membrane	ATP binding|ubiquitin-protein ligase activity				0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;6.66e-35)|OV - Ovarian serous cystadenocarcinoma(86;3.53e-21)|Colorectal(212;0.00019)|COAD - Colon adenocarcinoma(227;0.000215)|Kidney(185;0.00255)|BRCA - Breast invasive adenocarcinoma(365;0.00266)|STAD - Stomach adenocarcinoma(132;0.00645)|KIRC - Kidney renal clear cell carcinoma(229;0.0371)|Lung(427;0.205)		TCCACGTGTCCGGGTGGAAAT	0.642			NA											63	145					2.37532e-16	3.32545e-16	0.01441	1	0
Unknown	0	broad.mit.edu	37	1	1854885	1854885	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr1:1854885G>C	uc001aik.2	-	8	1291	c.441C>G	c.(439-441)TTC>TTG	p.F147L	uc001ail.2_Missense_Mutation_p.F147L					RecName: Full=Uncharacterized protein C1orf222;												NA						CGCCCTCCACGAACATCATGT	0.637			NA											5	14					0	0	0.001984	0	0
C1orf200	644997	broad.mit.edu	37	1	9713992	9713992	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr1:9713992G>A	uc001aqc.3	-	2	499	c.349C>T	c.(349-351)CGC>TGC	p.R117C	PIK3CD_uc001aqa.2_Intron|PIK3CD_uc001aqb.3_Intron	NR_027045				RecName: Full=Putative uncharacterized protein C1orf200;												0	all_lung(157;0.222)	Renal(390;0.000469)|all_lung(118;0.000521)|Lung NSC(185;0.000744)|Colorectal(325;0.0062)|Breast(348;0.0157)|Hepatocellular(190;0.0228)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.104)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;4.86e-08)|COAD - Colon adenocarcinoma(227;1.31e-05)|Kidney(185;0.000231)|KIRC - Kidney renal clear cell carcinoma(229;0.000879)|BRCA - Breast invasive adenocarcinoma(304;0.00178)|STAD - Stomach adenocarcinoma(132;0.00331)|READ - Rectum adenocarcinoma(331;0.0419)		Ggctgagagcggtagctcata	0.234			NA											15	26					0	0	0.004007	0	0
LOC649330	649330	broad.mit.edu	37	1	12908093	12908093	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr1:12908093C>A	uc009vno.2	-	1	145	c.50G>T	c.(49-51)CGT>CTT	p.R17L	HNRNPCL1_uc010obf.1_Missense_Mutation_p.R17L	NM_001146181	NP_001139653	B7ZW38	B7ZW38_HUMAN	heterogeneous nuclear ribonucleoprotein C-like	17							nucleic acid binding|nucleotide binding				0						AATGAACACACGGGAGTTCAT	0.468			NA											16	174					1.67942e-08	2.01256e-08	0.006122	1	0
CROCC	9696	broad.mit.edu	37	1	17257855	17257855	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr1:17257855C>T	uc001azt.2	+	8	988	c.919C>T	c.(919-921)CGG>TGG	p.R307W	CROCC_uc009voy.1_Intron|CROCC_uc009voz.1_Missense_Mutation_p.R70W	NM_014675	NP_055490	Q5TZA2	CROCC_HUMAN	ciliary rootlet coiled-coil	307					cell cycle|cell projection organization|centrosome organization|protein localization	actin cytoskeleton|centriole|ciliary rootlet|plasma membrane	kinesin binding|structural molecule activity			ovary(2)|breast(2)|central_nervous_system(1)	5		Colorectal(325;3.46e-05)|Breast(348;0.000162)|Lung NSC(340;0.000174)|all_lung(284;0.000234)|Renal(390;0.000518)|Ovarian(437;0.00669)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.63e-06)|COAD - Colon adenocarcinoma(227;1.07e-05)|Kidney(64;0.000163)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.181)		GGTGGGGTTCCGGCGGCTGGT	0.622			NA											22	103					0	0	0.007291	0	0
PAX7	5081	broad.mit.edu	37	1	19062359	19062359	+	Silent	SNP	C	C	A			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr1:19062359C>A	uc001bay.2	+	8	1987	c.1389C>A	c.(1387-1389)GGC>GGA	p.G463G	PAX7_uc001baz.2_Silent_p.G461G|PAX7_uc010oct.1_Silent_p.G463G	NM_002584	NP_002575	P23759	PAX7_HUMAN	paired box 7 isoform 1	463					anti-apoptosis	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		PAX7/FOXO1(197)	soft_tissue(197)|lung(3)|prostate(1)|ovary(1)|breast(1)	203		Colorectal(325;3.46e-05)|all_lung(284;0.000439)|Renal(390;0.000518)|Lung NSC(340;0.000543)|Breast(348;0.00093)|Ovarian(437;0.00768)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00609)|BRCA - Breast invasive adenocarcinoma(304;4.71e-05)|Kidney(64;0.000279)|KIRC - Kidney renal clear cell carcinoma(64;0.00371)|STAD - Stomach adenocarcinoma(196;0.00658)|READ - Rectum adenocarcinoma(331;0.0576)		ATCAGTACGGCCAGTACGGCC	0.637			NA	T	FOXO1A	alveolar rhabdomyosarcoma								13	68					1.33834e-09	1.64862e-09	0.007413	1	0
TAS1R2	80834	broad.mit.edu	37	1	19181144	19181144	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr1:19181144C>T	uc001bba.1	-	3	821	c.820G>A	c.(820-822)GTG>ATG	p.V274M		NM_152232	NP_689418	Q8TE23	TS1R2_HUMAN	taste receptor, type 1, member 2 precursor	274	Extracellular (Potential).				detection of chemical stimulus involved in sensory perception of sweet taste	plasma membrane	protein heterodimerization activity|taste receptor activity			skin(2)|ovary(1)|central_nervous_system(1)	4		Colorectal(325;3.46e-05)|all_lung(284;0.000321)|Lung NSC(340;0.000398)|Renal(390;0.000518)|Breast(348;0.000812)|Ovarian(437;0.00764)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00466)|BRCA - Breast invasive adenocarcinoma(304;3.56e-05)|Kidney(64;0.000177)|KIRC - Kidney renal clear cell carcinoma(64;0.00262)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)	Aspartame(DB00168)	GGCGAGAACACGACCACGACG	0.627			NA											4	52					0	0	0.009096	0	0
USP48	84196	broad.mit.edu	37	1	22083110	22083110	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr1:22083110C>T	uc001bfb.2	-	3	579	c.341G>A	c.(340-342)CGG>CAG	p.R114Q	USP48_uc010odq.1_Missense_Mutation_p.R114Q|USP48_uc009vqc.2_Missense_Mutation_p.R114Q|USP48_uc001bfc.2_Missense_Mutation_p.R114Q|USP48_uc001bfe.1_Missense_Mutation_p.R114Q|USP48_uc001bff.2_Missense_Mutation_p.R114Q	NM_032236	NP_115612	Q86UV5	UBP48_HUMAN	ubiquitin specific protease 48 isoform a	114					ubiquitin-dependent protein catabolic process	mitochondrion|nucleus	cysteine-type peptidase activity|ubiquitin thiolesterase activity			ovary(1)|lung(1)	2		Colorectal(325;3.46e-05)|all_lung(284;4.29e-05)|Lung NSC(340;4.66e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0182)|OV - Ovarian serous cystadenocarcinoma(117;4.74e-26)|COAD - Colon adenocarcinoma(152;1.3e-05)|GBM - Glioblastoma multiforme(114;1.86e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000614)|STAD - Stomach adenocarcinoma(196;0.00644)|KIRC - Kidney renal clear cell carcinoma(1967;0.00711)|Lung(427;0.0327)|READ - Rectum adenocarcinoma(331;0.0657)|LUSC - Lung squamous cell carcinoma(448;0.0753)		GAGTGCCTGCCGAAGCTCCAA	0.468			NA											31	157					0	0	0.007291	0	0
CNR2	1269	broad.mit.edu	37	1	24201556	24201556	+	Silent	SNP	T	T	A			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr1:24201556T>A	uc001bif.2	-	2	679	c.552A>T	c.(550-552)CCA>CCT	p.P184P		NM_001841	NP_001832	P34972	CNR2_HUMAN	cannabinoid receptor 2 (macrophage)	184	Extracellular (Potential).				behavior|G-protein signaling, coupled to cyclic nucleotide second messenger|immune response|inflammatory response	dendrite|integral to plasma membrane|perikaryon	cannabinoid receptor activity			skin(2)|central_nervous_system(1)	3		Colorectal(325;3.46e-05)|Renal(390;0.000219)|Lung NSC(340;0.000233)|all_lung(284;0.000321)|Ovarian(437;0.00348)|Breast(348;0.00957)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;1.32e-24)|Colorectal(126;6.09e-08)|COAD - Colon adenocarcinoma(152;3.33e-06)|GBM - Glioblastoma multiforme(114;2.9e-05)|BRCA - Breast invasive adenocarcinoma(304;0.00101)|KIRC - Kidney renal clear cell carcinoma(1967;0.00359)|STAD - Stomach adenocarcinoma(196;0.0131)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.146)	Nabilone(DB00486)	TGGGGATCAGTGGGAAAAGCT	0.562			NA											12	69					0	0	0.00245	0	0
MATN1	4146	broad.mit.edu	37	1	31189047	31189047	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr1:31189047C>T	uc001brz.2	-	5	950	c.916G>A	c.(916-918)GAC>AAC	p.D306N	uc001bsb.1_5'Flank|MATN1_uc001bsa.1_Missense_Mutation_p.D224N	NM_002379	NP_002370	P21941	MATN1_HUMAN	matrilin 1, cartilage matrix protein precursor	306	VWFA 2.				protein complex assembly	proteinaceous extracellular matrix	extracellular matrix structural constituent|protein binding			central_nervous_system(1)	1		Colorectal(325;0.00792)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)|Ovarian(437;0.0563)|Breast(348;0.0848)|Medulloblastoma(700;0.123)		Colorectal(126;1.29e-05)|COAD - Colon adenocarcinoma(152;0.000726)|STAD - Stomach adenocarcinoma(196;0.0183)|READ - Rectum adenocarcinoma(331;0.0649)		TCTGACACGTCCAGCGTATCC	0.562			NA											30	74					0	0	0.007835	0	0
ZMYM1	79830	broad.mit.edu	37	1	35579110	35579110	+	Missense_Mutation	SNP	A	A	T			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr1:35579110A>T	uc001bym.2	+	11	1827	c.1679A>T	c.(1678-1680)AAT>ATT	p.N560I	ZMYM1_uc001byn.2_Missense_Mutation_p.N560I|ZMYM1_uc010ohu.1_Missense_Mutation_p.N541I|ZMYM1_uc001byo.2_Missense_Mutation_p.N200I|ZMYM1_uc009vut.2_Missense_Mutation_p.N485I	NM_024772	NP_079048	Q5SVZ6	ZMYM1_HUMAN	zinc finger, MYM domain containing 1	560						nucleus	nucleic acid binding|protein dimerization activity|zinc ion binding				0		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				ATAATTGAAAATATTTTATTT	0.318			NA											27	34					0	0	0.008361	0	0
C1orf216	127703	broad.mit.edu	37	1	36181806	36181806	+	Silent	SNP	G	G	C			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr1:36181806G>C	uc001bzh.1	-	2	605	c.117C>G	c.(115-117)GCC>GCG	p.A39A		NM_152374	NP_689587	Q8TAB5	CA216_HUMAN	hypothetical protein LOC127703	39										skin(1)	1		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.196)				TAGCATCCTTGGCACTTGCCA	0.577			NA									OREG0013357	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	25	113					0	0	0.004656	0	0
ATP6V0B	533	broad.mit.edu	37	1	44441472	44441472	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr1:44441472G>T	uc001cld.2	+	2	179	c.68G>T	c.(67-69)GGA>GTA	p.G23V	ATP6V0B_uc001clc.2_Missense_Mutation_p.G23V|ATP6V0B_uc001cle.2_Intron|ATP6V0B_uc001clf.2_5'UTR	NM_004047	NP_004038	Q99437	VATO_HUMAN	ATPase, H+ transporting, lysosomal 21kDa, V0	23	Helical; (Potential).				ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|insulin receptor signaling pathway|transferrin transport	endosome membrane|integral to membrane|proton-transporting V-type ATPase, V0 domain|vacuolar membrane	hydrogen ion transmembrane transporter activity			breast(1)	1	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0511)				ACTGCTGCAGGAGTCTGCTAC	0.552			NA											150	349					1.46247e-67	2.53917e-67	0.01441	1	0
TCTEX1D1	200132	broad.mit.edu	37	1	67241985	67241985	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr1:67241985G>T	uc001dcv.2	+	4	366	c.235G>T	c.(235-237)GTC>TTC	p.V79F	TCTEX1D1_uc009wau.2_RNA|TCTEX1D1_uc009wav.2_Intron	NM_152665	NP_689878	Q8N7M0	TC1D1_HUMAN	Tctex1 domain containing 1	79											0						TTTTCCTGTGGTCACCGTCAA	0.358			NA											15	32					3.99206e-14	5.38378e-14	0.007413	1	0
LPHN2	23266	broad.mit.edu	37	1	82409048	82409048	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr1:82409048G>C	uc001dit.3	+	6	974	c.793G>C	c.(793-795)GAC>CAC	p.D265H	LPHN2_uc001dis.2_Intron|LPHN2_uc001diu.2_Missense_Mutation_p.D265H|LPHN2_uc001div.2_Missense_Mutation_p.D265H|LPHN2_uc009wcd.2_Missense_Mutation_p.D265H	NM_012302	NP_036434	O95490	LPHN2_HUMAN	latrophilin 2 precursor	265	Extracellular (Potential).|Olfactomedin-like.				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|latrotoxin receptor activity|sugar binding			ovary(3)|lung(3)|breast(2)|central_nervous_system(1)	9				all cancers(265;0.00142)|Epithelial(280;0.00829)|OV - Ovarian serous cystadenocarcinoma(397;0.077)|STAD - Stomach adenocarcinoma(256;0.248)		GACTGATATCGACCTAGCAGT	0.408			NA											21	39					0	0	0.00333	0	0
RPAP2	79871	broad.mit.edu	37	1	92789591	92789591	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr1:92789591G>C	uc001dot.2	+	8	1223	c.1114G>C	c.(1114-1116)GAG>CAG	p.E372Q	RPAP2_uc009wdh.2_RNA	NM_024813	NP_079089	Q8IXW5	RPAP2_HUMAN	RNA polymerase II associated protein 2	372						integral to membrane|nucleus	metal ion binding|phosphoprotein phosphatase activity			ovary(1)	1		all_lung(203;0.0565)|Lung NSC(277;0.152)|Glioma(108;0.222)		all cancers(265;0.00647)|GBM - Glioblastoma multiforme(16;0.0234)|Epithelial(280;0.115)		AGTTTTGAAGGAGACTTTGAT	0.403			NA											17	89					0	0	0.006122	0	0
VCAM1	7412	broad.mit.edu	37	1	101185437	101185437	+	Silent	SNP	G	G	T			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr1:101185437G>T	uc001dti.2	+	1	141	c.21G>T	c.(19-21)GTG>GTT	p.V7V	VCAM1_uc001dtj.2_Silent_p.V7V|VCAM1_uc010ouj.1_Silent_p.V7V	NM_001078	NP_001069	P19320	VCAM1_HUMAN	vascular cell adhesion molecule 1 isoform a	7					heterophilic cell-cell adhesion|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|leukocyte tethering or rolling|membrane to membrane docking|positive regulation of T cell proliferation|regulation of immune response	alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex|apical part of cell|external side of plasma membrane|extracellular space|filopodium|integral to membrane|microvillus|podosome	cell adhesion molecule binding|integrin binding			central_nervous_system(1)	1		all_epithelial(167;3.83e-06)|all_lung(203;0.000485)|Lung NSC(277;0.0011)		Epithelial(280;0.0227)|all cancers(265;0.0276)|COAD - Colon adenocarcinoma(174;0.149)|Colorectal(144;0.169)|Lung(183;0.196)	Carvedilol(DB01136)	AGATGGTCGTGATCCTTGGAG	0.413			NA											15	43					1.55795e-14	2.11401e-14	0.012319	1	0
SEC22B	9554	broad.mit.edu	37	1	145115850	145115850	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr1:145115850C>A	uc001eml.1	+	7	749	c.609C>A	c.(607-609)TTC>TTA	p.F203L	NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron	NM_004892	NP_004883	O75396	SC22B_HUMAN	SEC22 vesicle trafficking protein homolog B	203	Helical; Anchor for type IV membrane protein; (Potential).				ER to Golgi vesicle-mediated transport|protein transport	endoplasmic reticulum membrane|ER-Golgi intermediate compartment membrane|Golgi membrane|integral to membrane|melanosome	protein binding				0						CTGTATTTTTCATCATGTTAA	0.413			NA											17	117					1.96895e-08	2.34045e-08	0.00278	1	0
FLG	2312	broad.mit.edu	37	1	152277110	152277110	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr1:152277110C>A	uc001ezu.1	-	3	10288	c.10252G>T	c.(10252-10254)GCA>TCA	p.A3418S		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	3418	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CTGTCTCGTGCCTGCTCGTGG	0.597			NA							Ichthyosis				87	582					3.34506e-74	5.85385e-74	0.01441	1	0
KPRP	448834	broad.mit.edu	37	1	152733141	152733141	+	Silent	SNP	G	G	A			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr1:152733141G>A	uc001fal.1	+	2	1135	c.1077G>A	c.(1075-1077)CCG>CCA	p.P359P		NM_001025231	NP_001020402	Q5T749	KPRP_HUMAN	keratinocyte proline-rich protein	359	Pro-rich.					cytoplasm				ovary(4)|pancreas(1)	5	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			GCTGTGGCCCGCAGCCCTCCT	0.647			NA											4	147					0	0	0.009096	0	0
ATP8B2	57198	broad.mit.edu	37	1	154317977	154317977	+	Missense_Mutation	SNP	A	A	T			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr1:154317977A>T	uc001fex.2	+	23	2749	c.2749A>T	c.(2749-2751)ATG>TTG	p.M917L		NM_020452	NP_065185	P98198	AT8B2_HUMAN	ATPase, class I, type 8B, member 2 isoform a	903	Helical; (Potential).				ATP biosynthetic process	plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(1)|skin(1)	2	all_lung(78;2.62e-30)|Lung NSC(65;3.94e-28)|Hepatocellular(266;0.0877)		LUSC - Lung squamous cell carcinoma(543;0.185)			TGCTTTCACCATGGTCCACTT	0.433			NA									OREG0013835	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	49	803					0	0	0.01441	0	0
DCST2	127579	broad.mit.edu	37	1	155002563	155002563	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr1:155002563G>A	uc001fgm.2	-	7	1254	c.1174C>T	c.(1174-1176)CCG>TCG	p.P392S	DCST2_uc009wpb.2_RNA	NM_144622	NP_653223	Q5T1A1	DCST2_HUMAN	DC-STAMP domain containing 2	392	Cytoplasmic (Potential).					integral to membrane				ovary(2)|central_nervous_system(1)	3	all_epithelial(22;2.77e-30)|all_lung(78;4.1e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		BRCA - Breast invasive adenocarcinoma(34;0.00034)			CCCTCACCCGGTGGGATGTAG	0.697			NA											21	197					0	0	0.014323	0	0
INSRR	3645	broad.mit.edu	37	1	156810734	156810734	+	Silent	SNP	G	G	T			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr1:156810734G>T	uc010pht.1	-	22	4079	c.3825C>A	c.(3823-3825)ACC>ACA	p.T1275T	NTRK1_uc001fqf.1_Intron|NTRK1_uc009wsi.1_Intron	NM_014215	NP_055030	P14616	INSRR_HUMAN	insulin receptor-related receptor precursor	1275	Cytoplasmic (Potential).				protein autophosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|insulin receptor substrate binding|metal ion binding|phosphatidylinositol 3-kinase binding|transmembrane receptor protein tyrosine kinase activity			lung(11)|ovary(5)|skin(2)|kidney(1)|central_nervous_system(1)	20	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					GCTCTGCATCGGTGGTAGGCA	0.647			NA											4	73					8.12818e-05	8.76413e-05	0.001984	1	0
FCRL2	79368	broad.mit.edu	37	1	157738300	157738300	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr1:157738300G>T	uc001fre.2	-	5	846	c.787C>A	c.(787-789)CCA>ACA	p.P263T	FCRL2_uc001frd.2_5'Flank|FCRL2_uc010phz.1_Missense_Mutation_p.P263T|FCRL2_uc009wsp.2_Intron	NM_030764	NP_110391	Q96LA5	FCRL2_HUMAN	Fc receptor-like 2 precursor	263	Ig-like C2-type 3.|Extracellular (Potential).				cell-cell signaling	integral to membrane|plasma membrane|soluble fraction	receptor activity|SH3/SH2 adaptor activity			ovary(1)|pancreas(1)	2	all_hematologic(112;0.0378)		LUSC - Lung squamous cell carcinoma(543;0.24)			TTCACAGCTGGGATCTCCAGC	0.512			NA											143	214					3.42498e-63	5.9232e-63	0.01441	1	0
SPTA1	6708	broad.mit.edu	37	1	158615031	158615031	+	Nonsense_Mutation	SNP	C	C	A			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr1:158615031C>A	uc001fst.1	-	29	4340	c.4141G>T	c.(4141-4143)GAG>TAG	p.E1381*		NM_003126	NP_003117	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1	1381	Spectrin 13.				actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|breast(1)	8	all_hematologic(112;0.0378)					CAAGCCTTCTCCAAATCATCT	0.448			NA											144	140					1.97865e-72	3.44895e-72	0.01441	1	0
OR10J3	441911	broad.mit.edu	37	1	159284169	159284169	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr1:159284169G>A	uc010piu.1	-	1	281	c.281C>T	c.(280-282)GCC>GTC	p.A94V		NM_001004467	NP_001004467	Q5JRS4	O10J3_HUMAN	olfactory receptor, family 10, subfamily J,	94	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	all_hematologic(112;0.0429)					GCTTTGGGTGGCAATGGGCTG	0.498			NA											8	142					0	0	0.00308	0	0
OR10J1	26476	broad.mit.edu	37	1	159410018	159410018	+	Missense_Mutation	SNP	T	T	A			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr1:159410018T>A	uc010piv.1	+	1	470	c.470T>A	c.(469-471)CTG>CAG	p.L157Q	uc001fts.3_Intron	NM_012351	NP_036483	P30954	O10J1_HUMAN	olfactory receptor, family 10, subfamily J,	157	Helical; Name=4; (Potential).				sensory perception of smell|single fertilization	integral to plasma membrane	olfactory receptor activity			ovary(1)	1	all_hematologic(112;0.0429)					CAACTTGTCCTGGGGGCCTGC	0.498			NA											150	116					0	0	0.01441	0	0
TAGLN2	8407	broad.mit.edu	37	1	159888698	159888698	+	Silent	SNP	A	A	G			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr1:159888698A>G	uc001fum.1	-	4	542	c.492T>C	c.(490-492)GAT>GAC	p.D164D	CCDC19_uc001ful.2_Intron|TAGLN2_uc001fun.1_Silent_p.D164D|TAGLN2_uc001fuo.1_3'UTR	NM_003564	NP_003555	P37802	TAGL2_HUMAN	transgelin 2	164					muscle organ development	nuclear membrane|plasma membrane	protein binding				0	all_hematologic(112;0.0597)		BRCA - Breast invasive adenocarcinoma(70;0.111)			GCAGCTGGTTATCCGAGAAGT	0.552			NA											34	256					0	0	0.004878	0	0
NOS1AP	9722	broad.mit.edu	37	1	162313767	162313767	+	Splice_Site	SNP	G	G	C			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr1:162313767G>C	uc001gbv.2	+	6	982	c.595_splice	c.e6+1	p.G199_splice	NOS1AP_uc010pkr.1_Splice_Site_p.G194_splice|NOS1AP_uc010pks.1_Splice_Site|NOS1AP_uc001gbw.2_Splice_Site_p.G194_splice	NM_014697	NP_055512	O75052	CAPON_HUMAN	nitric oxide synthase 1 (neuronal) adaptor						regulation of apoptosis|regulation of nitric oxide biosynthetic process|regulation of nitric-oxide synthase activity		nitric-oxide synthase binding|PDZ domain binding			lung(2)|upper_aerodigestive_tract(1)	3	all_hematologic(112;0.203)		BRCA - Breast invasive adenocarcinoma(70;0.0537)			GGAGACCCAGGTAGGCACTGC	0.582			NA											48	31					0	0	0.01441	0	0
METTL13	51603	broad.mit.edu	37	1	171755174	171755174	+	Missense_Mutation	SNP	A	A	G			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr1:171755174A>G	uc001ghz.2	+	3	1416	c.1069A>G	c.(1069-1071)AGA>GGA	p.R357G	METTL13_uc001gia.2_Missense_Mutation_p.R271G|METTL13_uc001gib.2_Missense_Mutation_p.R201G|METTL13_uc010pml.1_Missense_Mutation_p.R356G	NM_015935	NP_057019	Q8N6R0	MTL13_HUMAN	CGI-01 protein isoform 1	357							methyltransferase activity|protein binding			kidney(1)	1						GCTGTCGGCTAGAGTCATGGA	0.572			NA											5	75					0	0	0.00308	0	0
TNR	7143	broad.mit.edu	37	1	175324739	175324739	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr1:175324739C>A	uc001gkp.1	-	15	3230	c.3149G>T	c.(3148-3150)AGT>ATT	p.S1050I	TNR_uc009wwu.1_Missense_Mutation_p.S1050I	NM_003285	NP_003276	Q92752	TENR_HUMAN	tenascin R precursor	1050	Fibronectin type-III 9.				axon guidance|cell adhesion|signal transduction	proteinaceous extracellular matrix				pancreas(5)|ovary(4)|central_nervous_system(1)|skin(1)	11	Renal(580;0.146)					GGTGACTTCACTGGCTGTCAG	0.552			NA											89	51					3.10586e-51	5.32951e-51	0.01441	1	0
TNR	7143	broad.mit.edu	37	1	175372653	175372653	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr1:175372653G>A	uc001gkp.1	-	2	680	c.599C>T	c.(598-600)TCG>TTG	p.S200L	TNR_uc009wwu.1_Missense_Mutation_p.S200L|TNR_uc010pmz.1_Missense_Mutation_p.S200L	NM_003285	NP_003276	Q92752	TENR_HUMAN	tenascin R precursor	200	Cys-rich.				axon guidance|cell adhesion|signal transduction	proteinaceous extracellular matrix				pancreas(5)|ovary(4)|central_nervous_system(1)|skin(1)	11	Renal(580;0.146)					GTAGGGCTCCGAGCAATTCTT	0.582			NA											38	310					0	0	0.009718	0	0
FAM5B	57795	broad.mit.edu	37	1	177226496	177226496	+	Silent	SNP	C	C	A			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr1:177226496C>A	uc001glf.2	+	4	957	c.645C>A	c.(643-645)ATC>ATA	p.I215I	FAM5B_uc010pna.1_5'UTR|FAM5B_uc001glg.2_Silent_p.I110I	NM_021165	NP_066988	Q9C0B6	FAM5B_HUMAN	family with sequence similarity 5, member B	215						extracellular region				skin(3)|ovary(2)|upper_aerodigestive_tract(1)	6						TGCACCATATCCAGATAGCCA	0.612			NA											33	21					1.56738e-10	1.96927e-10	0.004289	1	0
HMCN1	83872	broad.mit.edu	37	1	186086738	186086738	+	Missense_Mutation	SNP	A	A	G			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr1:186086738A>G	uc001grq.1	+	77	12060	c.11831A>G	c.(11830-11832)TAT>TGT	p.Y3944C		NM_031935	NP_114141	Q96RW7	HMCN1_HUMAN	hemicentin 1 precursor	3944	Ig-like C2-type 38.				response to stimulus|visual perception	basement membrane	calcium ion binding			ovary(22)|skin(1)	23						GGAGATGGCTATAGAATTCTG	0.433			NA											69	42					0	0	0.01441	0	0
LRRN2	10446	broad.mit.edu	37	1	204588748	204588748	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr1:204588748C>G	uc001hbe.1	-	3	761	c.373G>C	c.(373-375)GAG>CAG	p.E125Q	MDM4_uc001hbd.1_Intron|LRRN2_uc001hbf.1_Missense_Mutation_p.E125Q|LRRN2_uc009xbf.1_Missense_Mutation_p.E125Q|MDM4_uc001hbc.2_Intron	NM_006338	NP_006329	O75325	LRRN2_HUMAN	leucine rich repeat neuronal 2 precursor	125	LRR 3.|Extracellular (Potential).				cell adhesion	integral to membrane	receptor activity			central_nervous_system(2)	2	all_cancers(21;0.0519)|Breast(84;0.112)|Prostate(682;0.19)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.143)			TGGTTCTCCTCTAGGTGCAGG	0.602			NA											4	420					0	0	0.001168	0	0
CENPF	1063	broad.mit.edu	37	1	214791961	214791961	+	Silent	SNP	A	A	T			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr1:214791961A>T	uc001hkm.2	+	4	579	c.405A>T	c.(403-405)GCA>GCT	p.A135A		NM_016343	NP_057427	P49454	CENPF_HUMAN	centromere protein F	135	Interaction with SNAP25 and required for localization to the cytoplasm (By similarity).|Potential.				cell differentiation|cell division|cell proliferation|DNA replication|G2 phase of mitotic cell cycle|kinetochore assembly|metaphase plate congression|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|muscle organ development|negative regulation of transcription, DNA-dependent|protein transport|regulation of G2/M transition of mitotic cell cycle|regulation of striated muscle tissue development|response to drug	condensed chromosome outer kinetochore|cytosol|midbody|nuclear envelope|nuclear matrix|perinuclear region of cytoplasm|spindle pole	chromatin binding|dynein binding|protein C-terminus binding|protein homodimerization activity|transcription factor binding			ovary(6)|central_nervous_system(4)|large_intestine(2)|skin(1)	13				all cancers(67;0.00836)|OV - Ovarian serous cystadenocarcinoma(81;0.00855)|GBM - Glioblastoma multiforme(131;0.0694)|Epithelial(68;0.0833)		CGCAGTCTGCAGATGTCTCTC	0.398	Colon(80;575 1284 11000 14801 43496)		NA											19	118					0	0	0.007413	0	0
USH2A	7399	broad.mit.edu	37	1	215848813	215848813	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr1:215848813G>T	uc001hku.1	-	63	12827	c.12440C>A	c.(12439-12441)CCT>CAT	p.P4147H		NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	4147	Fibronectin type-III 26.|Extracellular (Potential).				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		TGTCCACAGAGGCTGAGGCGC	0.572			NA								HNSCC(13;0.011)			12	61					5.50884e-06	6.13484e-06	0.013537	1	0
EPRS	2058	broad.mit.edu	37	1	220178627	220178627	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr1:220178627C>T	uc001hly.1	-	16	2296	c.2026G>A	c.(2026-2028)GGA>AGA	p.G676R	EPRS_uc010puf.1_Missense_Mutation_p.G427R|EPRS_uc001hlz.1_Missense_Mutation_p.G683R|EPRS_uc009xdt.1_Missense_Mutation_p.G264R	NM_004446	NP_004437	P07814	SYEP_HUMAN	glutamyl-prolyl tRNA synthetase	676	Glutamyl-tRNA synthetase.				glutamyl-tRNA aminoacylation|prolyl-tRNA aminoacylation|protein complex assembly	cytosol|soluble fraction	ATP binding|glutamate-tRNA ligase activity|proline-tRNA ligase activity|protein binding|RNA binding			ovary(1)|skin(1)	2				GBM - Glioblastoma multiforme(131;0.0735)	L-Glutamic Acid(DB00142)|L-Proline(DB00172)	ATGAAGAATCCTCTTCTCTGG	0.333			NA											6	70					0	0	0.001984	0	0
TAF1A	9015	broad.mit.edu	37	1	222761891	222761891	+	Missense_Mutation	SNP	A	A	T			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr1:222761891A>T	uc009xdz.1	-	2	204	c.15T>A	c.(13-15)AGT>AGA	p.S5R	TAF1A_uc001hni.1_5'UTR|TAF1A_uc001hnj.2_Missense_Mutation_p.S5R|TAF1A_uc001hnk.2_5'UTR|TAF1A_uc010pur.1_Missense_Mutation_p.S5R	NM_139352	NP_647603	Q15573	TAF1A_HUMAN	TBP-associated factor 1A isoform 2	5					regulation of transcription, DNA-dependent|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase I promoter	RNA polymerase I transcription factor complex	DNA binding				0				GBM - Glioblastoma multiforme(131;0.0186)		TTAATTCTTCACTGAAATCAC	0.378			NA											19	218					0	0	0.012319	0	0
C1orf55	163859	broad.mit.edu	37	1	226183030	226183030	+	Missense_Mutation	SNP	T	T	C			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr1:226183030T>C	uc001hpu.3	-	2	228	c.175A>G	c.(175-177)AGT>GGT	p.S59G	C1orf55_uc001hpv.2_Missense_Mutation_p.S59G	NM_152608	NP_689821	Q6IQ49	CA055_HUMAN	hypothetical protein LOC163859	59										lung(1)	1	Breast(184;0.197)					ACTGTGTCACTGGTGTTAATG	0.383			NA											21	220					0	0	0.008871	0	0
SIPA1L2	57568	broad.mit.edu	37	1	232619633	232619633	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr1:232619633G>A	uc001hvg.2	-	4	2044	c.1886C>T	c.(1885-1887)ACG>ATG	p.T629M		NM_020808	NP_065859	Q9P2F8	SI1L2_HUMAN	signal-induced proliferation-associated 1 like	629	Rap-GAP.				regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			ovary(2)|central_nervous_system(2)|pancreas(1)|skin(1)	6		all_cancers(173;0.00605)|Prostate(94;0.128)|all_epithelial(177;0.186)				TGGTCCCGCCGTCTCATTGTT	0.448			NA											10	103					0	0	0.013537	0	0
RYR2	6262	broad.mit.edu	37	1	237713886	237713886	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr1:237713886C>T	uc001hyl.1	+	27	3229	c.3109C>T	c.(3109-3111)CTT>TTT	p.L1037F		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	1037	Cytoplasmic (By similarity).|2.|B30.2/SPRY 2.|4 X approximate repeats.			L -> P (in Ref. 1; CAA66975 and 2; CAC18855).	cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			TCCCTACACTCTTCTGGATGA	0.512			NA											15	12					0	0	0.003163	0	0
OR2T33	391195	broad.mit.edu	37	1	248436566	248436566	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr1:248436566C>A	uc010pzi.1	-	1	551	c.551G>T	c.(550-552)CGT>CTT	p.R184L		NM_001004695	NP_001004695	Q8NG76	O2T33_HUMAN	olfactory receptor, family 2, subfamily T,	184	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(1)|ovary(1)	2	all_cancers(71;0.000124)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			ACAAGCCAAACGCACCAGCAC	0.542			NA											11	168					2.79863e-10	3.50624e-10	0.004656	1	0
WDR37	22884	broad.mit.edu	37	10	1151165	1151165	+	Missense_Mutation	SNP	A	A	C			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr10:1151165A>C	uc001igf.1	+	11	1234	c.1061A>C	c.(1060-1062)GAC>GCC	p.D354A	WDR37_uc009xhm.1_Missense_Mutation_p.D355A|WDR37_uc009xhn.1_RNA|WDR37_uc001igg.1_RNA	NM_014023	NP_054742	Q9Y2I8	WDR37_HUMAN	WD repeat domain 37	354	WD 4.										0		all_epithelial(10;0.0449)|Colorectal(49;0.142)		Epithelial(11;0.134)		GATTTCAGGGACCCCTCCATC	0.567			NA											4	24					0	0	0.008291	0	0
FBXO18	84893	broad.mit.edu	37	10	5955787	5955787	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr10:5955787C>T	uc001iis.2	+	7	1384	c.1289C>T	c.(1288-1290)CCA>CTA	p.P430L	FBXO18_uc001iir.2_Missense_Mutation_p.P356L|FBXO18_uc009xig.2_Missense_Mutation_p.P356L|FBXO18_uc001iit.2_Missense_Mutation_p.P481L	NM_178150	NP_835363	Q8NFZ0	FBX18_HUMAN	F-box only protein, helicase, 18 isoform 2	430					DNA repair	nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding			ovary(2)|skin(1)	3						AAAGAGGAGCCATCTGTCTGG	0.413			NA											33	54					0	0	0.012213	0	0
ITIH2	3698	broad.mit.edu	37	10	7759743	7759743	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr10:7759743C>T	uc001ijs.2	+	6	784	c.622C>T	c.(622-624)CAC>TAC	p.H208Y		NM_002216	NP_002207	P19823	ITIH2_HUMAN	inter-alpha globulin inhibitor H2 polypeptide	208					hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			ovary(1)|pancreas(1)|skin(1)	3						GCTGGCCAAACACTTAGAGGT	0.502			NA											69	191					0	0	0.01441	0	0
ARMC3	219681	broad.mit.edu	37	10	23270392	23270392	+	Nonsense_Mutation	SNP	C	C	A			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr10:23270392C>A	uc001irm.3	+	9	1123	c.1040C>A	c.(1039-1041)TCA>TAA	p.S347*	ARMC3_uc010qcv.1_Nonsense_Mutation_p.S347*|ARMC3_uc010qcw.1_Nonsense_Mutation_p.S84*	NM_173081	NP_775104	Q5W041	ARMC3_HUMAN	armadillo repeat containing 3	347	ARM 9.						binding				0						TGTGAGAATTCAGGCAGCAAA	0.373			NA											19	42					7.45023e-12	9.69189e-12	0.010504	1	0
PSAP	5660	broad.mit.edu	37	10	73579275	73579275	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr10:73579275G>T	uc001jsm.2	-	11	1401	c.1297C>A	c.(1297-1299)CTG>ATG	p.L433M	PSAP_uc001jsl.2_Missense_Mutation_p.L157M	NM_002778	NP_002769	P07602	SAP_HUMAN	prosaposin isoform a preproprotein	433	Saposin B-type 4.				glycosphingolipid metabolic process|lipid transport|platelet activation|platelet degranulation	extracellular space|Golgi apparatus|integral to membrane|lysosomal lumen	enzyme activator activity|lipid binding			ovary(1)	1						AGAGCAGCCAGGATCTCCTGC	0.577			NA											30	84					2.48696e-23	3.75599e-23	0.003271	1	0
USP54	159195	broad.mit.edu	37	10	75258547	75258547	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr10:75258547C>T	uc001juo.2	-	22	4912	c.4895G>A	c.(4894-4896)CGA>CAA	p.R1632Q	PPP3CB_uc001juf.2_5'Flank|PPP3CB_uc001jue.2_5'Flank|PPP3CB_uc001jug.2_5'Flank|PPP3CB_uc001jui.2_5'Flank|PPP3CB_uc001juh.2_5'Flank|USP54_uc010qkk.1_Missense_Mutation_p.R767Q|USP54_uc001juk.2_Missense_Mutation_p.R720Q|USP54_uc001jul.2_Missense_Mutation_p.R673Q|USP54_uc001jum.2_RNA|USP54_uc001jun.2_RNA	NM_152586	NP_689799	Q70EL1	UBP54_HUMAN	ubiquitin specific peptidase 54	1632					ubiquitin-dependent protein catabolic process		protein binding|ubiquitin thiolesterase activity			breast(3)|lung(2)|kidney(1)	6	Prostate(51;0.0112)					ATCTACTCTTCGAGGACCAGG	0.517	Colon(195;880 2046 8854 25025 38456)		NA											15	117					0	0	0.003163	0	0
PLCE1	51196	broad.mit.edu	37	10	95791385	95791385	+	Silent	SNP	C	C	T			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr10:95791385C>T	uc001kjk.2	+	2	1216	c.582C>T	c.(580-582)GAC>GAT	p.D194D	PLCE1_uc010qnx.1_Silent_p.D194D	NM_016341	NP_057425	Q9P212	PLCE1_HUMAN	phospholipase C, epsilon 1 isoform 1	194					activation of MAPK activity|activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|calcium-mediated signaling|cell proliferation|cytoskeleton organization|diacylglycerol biosynthetic process|elevation of cytosolic calcium ion concentration|epidermal growth factor receptor signaling pathway|glomerulus development|heart development|lipid catabolic process|Ras protein signal transduction|regulation of cell growth|regulation of G-protein coupled receptor protein signaling pathway|regulation of Ras protein signal transduction|regulation of smooth muscle contraction	cytosol|Golgi membrane|membrane fraction|plasma membrane	calcium ion binding|guanyl-nucleotide exchange factor activity|phosphatidylinositol phospholipase C activity|Ras GTPase binding|receptor signaling protein activity			ovary(2)|skin(1)	3		Colorectal(252;0.0458)				ATGAAGTTGACAGAAGAATGT	0.418			NA											17	68					0	0	0.006122	0	0
TLL2	7093	broad.mit.edu	37	10	98273371	98273371	+	Silent	SNP	C	C	A			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr10:98273371C>A	uc001kml.1	-	1	298	c.72G>T	c.(70-72)GGG>GGT	p.G24G	TLL2_uc009xvf.1_Silent_p.G24G	NM_012465	NP_036597	Q9Y6L7	TLL2_HUMAN	tolloid-like 2 precursor	24					cell differentiation|multicellular organismal development|proteolysis	extracellular region	calcium ion binding|metalloendopeptidase activity|zinc ion binding			ovary(1)|pancreas(1)|skin(1)	3		Colorectal(252;0.0846)		Epithelial(162;1.51e-07)|all cancers(201;7.59e-06)		CCCCGAGTCCCCCGGCGCCGC	0.726			NA											16	22					3.45872e-05	3.77548e-05	0.004007	1	0
PIK3AP1	118788	broad.mit.edu	37	10	98469537	98469537	+	Missense_Mutation	SNP	C	C	T	rs146527410	byFrequency	TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr10:98469537C>T	uc001kmq.2	-	2	345	c.217G>A	c.(217-219)GCG>ACG	p.A73T		NM_152309	NP_689522	Q6ZUJ8	BCAP_HUMAN	phosphoinositide-3-kinase adaptor protein 1	73						cytoplasm|plasma membrane				upper_aerodigestive_tract(3)|ovary(1)|skin(1)	5		Colorectal(252;0.0442)		Epithelial(162;6.29e-08)|all cancers(201;3.18e-06)		ACCAGCTCCGCGGACAGCAGC	0.652			NA											53	89					0	0	0.01441	0	0
ABCC2	1244	broad.mit.edu	37	10	101606844	101606844	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr10:101606844G>T	uc001kqf.2	+	30	4412	c.4273G>T	c.(4273-4275)GGG>TGG	p.G1425W		NM_000392	NP_000383	Q92887	MRP2_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP),	1425	Cytoplasmic (By similarity).|ABC transporter 2.					apical plasma membrane|integral to plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|organic anion transmembrane transporter activity			ovary(1)	1		Colorectal(252;0.234)		Epithelial(162;2.77e-10)|all cancers(201;2.47e-08)	Adenosine triphosphate(DB00171)|Norgestimate(DB00957)|Pravastatin(DB00175)|Saquinavir(DB01232)|Sulfinpyrazone(DB01138)	CCTGCAACTTGGGTTATCCCA	0.537			NA											71	143					1.68136e-41	2.80864e-41	0.01441	1	0
NEURL	9148	broad.mit.edu	37	10	105330758	105330758	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr10:105330758C>T	uc001kxh.2	+	2	625	c.215C>T	c.(214-216)TCC>TTC	p.S72F		NM_004210	NP_004201	O76050	NEU1A_HUMAN	neuralized-like	72	NHR 1.				nervous system development	perinuclear region of cytoplasm	zinc ion binding				0				Epithelial(162;2.12e-09)|all cancers(201;6.99e-08)|BRCA - Breast invasive adenocarcinoma(275;0.125)		ACCAAGGGCTCCCAGATCCTC	0.637			NA											65	161					0	0	0.01441	0	0
KNDC1	85442	broad.mit.edu	37	10	134997434	134997434	+	Missense_Mutation	SNP	G	G	A	rs144320928		TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr10:134997434G>A	uc001llz.1	+	5	567	c.566G>A	c.(565-567)CGG>CAG	p.R189Q	KNDC1_uc001lma.1_Missense_Mutation_p.R124Q	NM_152643	NP_689856	Q76NI1	VKIND_HUMAN	kinase non-catalytic C-lobe domain (KIND)	189	KIND 1.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction					upper_aerodigestive_tract(1)|ovary(1)	2		all_cancers(35;4.16e-10)|all_epithelial(44;2.07e-08)|Lung NSC(174;0.000845)|all_lung(145;0.00145)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.173)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;8.77e-06)|Epithelial(32;1.13e-05)|all cancers(32;1.51e-05)		CGCGTGTGCCGGAGCCTCTCT	0.607			NA											24	170					0	0	0.003954	0	0
LOC653544	653544	broad.mit.edu	37	10	135491123	135491123	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr10:135491123G>A	uc010qvi.1	+	1	845	c.734G>A	c.(733-735)GGC>GAC	p.G245D		NM_001127389	NP_001120861	F5GZ66	F5GZ66_HUMAN	double homeobox, 4-like	245						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						GCCCACACCGGCGCGTGGGGA	0.786			NA											4	18					0	0	0.006214	0	0
OR51D1	390038	broad.mit.edu	37	11	4661752	4661752	+	Silent	SNP	G	G	T			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr11:4661752G>T	uc010qyk.1	+	1	732	c.732G>T	c.(730-732)CGG>CGT	p.R244R		NM_001004751	NP_001004751	Q8NGF3	O51D1_HUMAN	olfactory receptor, family 51, subfamily D,	244	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;2.74e-13)|BRCA - Breast invasive adenocarcinoma(625;0.00435)|GBM - Glioblastoma multiforme(2;0.0841)|LUSC - Lung squamous cell carcinoma(625;0.19)		TGTCCTCTCGGAGGGCAGCAC	0.527			NA											65	151					1.7104e-27	2.70353e-27	0.01441	1	0
OR2AG1	144125	broad.mit.edu	37	11	6806427	6806428	+	Silent	DNP	CC	CC	AA			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr11:6806427_6806428CC>AA	uc001mer.1	+	1	159_160	c.159_160CC>AA	c.(157-162)GCCCGG>GCAAGG	p.53_54AR>AR		NM_001004489	NP_001004489	Q9H205	O2AG1_HUMAN	olfactory receptor, family 2, subfamily AG,	53_54	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)		Epithelial(150;2.19e-08)|BRCA - Breast invasive adenocarcinoma(625;0.129)		CCATGGAAGCCCGGCTCCACAT	0.545			NA											79	160					0	0	0.004672	0	0
TEAD1	7003	broad.mit.edu	37	11	12901386	12901386	+	Silent	SNP	G	G	A			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr11:12901386G>A	uc001mkj.3	+	6	1082	c.417G>A	c.(415-417)CCG>CCA	p.P139P	TEAD1_uc001mkk.3_Silent_p.P58P|TEAD1_uc009ygl.2_Silent_p.P33P	NM_021961	NP_068780	P28347	TEAD1_HUMAN	TEA domain family member 1	154	Pro-rich.				hippo signaling cascade		DNA binding|protein binding|sequence-specific DNA binding transcription factor activity				0				Epithelial(150;0.00223)|BRCA - Breast invasive adenocarcinoma(625;0.236)		CAGGGGCGCCGGGGGTAAGTC	0.597			NA											17	142					0	0	0.010504	0	0
PLEKHA7	144100	broad.mit.edu	37	11	16838843	16838843	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr11:16838843C>A	uc001mmo.2	-	11	1385	c.1370G>T	c.(1369-1371)CGC>CTC	p.R457L	PLEKHA7_uc010rcu.1_Missense_Mutation_p.R457L|PLEKHA7_uc010rcv.1_Missense_Mutation_p.R31L|PLEKHA7_uc001mmn.2_Missense_Mutation_p.R165L	NM_175058	NP_778228	Q6IQ23	PKHA7_HUMAN	pleckstrin homology domain containing, family A	457					epithelial cell-cell adhesion|zonula adherens maintenance	centrosome|zonula adherens	delta-catenin binding			skin(2)|central_nervous_system(1)	3						AGGACCCTGGCGAGGAAGCGT	0.587			NA											38	140					8.16277e-20	1.19594e-19	0.006999	1	0
NELL1	4745	broad.mit.edu	37	11	20982079	20982079	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr11:20982079G>A	uc001mqe.2	+	12	1426	c.1273G>A	c.(1273-1275)GTC>ATC	p.V425I	NELL1_uc001mqf.2_Missense_Mutation_p.V425I|NELL1_uc009yid.2_Missense_Mutation_p.V453I|NELL1_uc010rdo.1_Missense_Mutation_p.V368I|NELL1_uc010rdp.1_Missense_Mutation_p.V185I	NM_006157	NP_006148	Q92832	NELL1_HUMAN	nel-like 1 isoform 1 precursor	425	EGF-like 1.				cell adhesion|nervous system development	extracellular region	calcium ion binding|structural molecule activity			ovary(2)|large_intestine(1)	3						TTACATCTCTGTCCAGGGAGA	0.413			NA											34	93					0	0	0.004878	0	0
FIBIN	387758	broad.mit.edu	37	11	27016285	27016285	+	Missense_Mutation	SNP	A	A	T			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr11:27016285A>T	uc001mrd.2	+	1	658	c.212A>T	c.(211-213)CAG>CTG	p.Q71L		NM_203371	NP_976249	Q8TAL6	FIBIN_HUMAN	fin bud initiation factor homolog precursor	71						extracellular region|Golgi apparatus					0						GAGGGGAGCCAGGTTGGCAGC	0.662			NA											18	32					0	0	0.010504	0	0
OR5A2	219981	broad.mit.edu	37	11	59190046	59190046	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr11:59190046G>C	uc010rkt.1	-	1	381	c.381C>G	c.(379-381)ATC>ATG	p.I127M		NM_001001954	NP_001001954	Q8NGI9	OR5A2_HUMAN	olfactory receptor, family 5, subfamily A,	127	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						AGGGGTTGCAGATTGCAGCAT	0.478			NA											4	52					0	0	0.009096	0	0
MS4A4A	51338	broad.mit.edu	37	11	60064740	60064740	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr11:60064740C>T	uc001noz.2	+	3	282	c.272C>T	c.(271-273)ACT>ATT	p.T91I	MS4A4A_uc001npa.2_Missense_Mutation_p.T72I|MS4A4A_uc001npb.2_Missense_Mutation_p.T72I|MS4A4A_uc001npc.2_Missense_Mutation_p.T72I	NM_148975	NP_683876	Q96JQ5	M4A4A_HUMAN	membrane-spanning 4-domains, subfamily A, member	91	Extracellular (Potential).					integral to membrane	receptor activity				0						GCATCTAATACTTATGGAAGT	0.373			NA											13	39					0	0	0.001855	0	0
TUT1	64852	broad.mit.edu	37	11	62346199	62346199	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr11:62346199C>T	uc001nto.2	-	5	1146	c.1108G>A	c.(1108-1110)GAG>AAG	p.E370K	TUT1_uc001ntp.1_5'Flank	NM_022830	NP_073741	Q9H6E5	STPAP_HUMAN	terminal uridylyl transferase 1, U6	332					mRNA cleavage|mRNA polyadenylation|snRNA processing	nuclear speck|nucleolus	ATP binding|enzyme binding|mRNA 3'-UTR binding|polynucleotide adenylyltransferase activity|RNA uridylyltransferase activity|zinc ion binding			central_nervous_system(1)|skin(1)	2						GCTTTCTCCTCCTTTGGGGTC	0.617			NA											26	156					0	0	0.010818	0	0
SLC22A11	55867	broad.mit.edu	37	11	64331815	64331815	+	Missense_Mutation	SNP	A	A	T			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr11:64331815A>T	uc001oai.2	+	5	1231	c.857A>T	c.(856-858)AAG>ATG	p.K286M	SLC22A11_uc001oah.1_Intron|SLC22A11_uc001oaj.2_Missense_Mutation_p.K286M|SLC22A11_uc009ypq.2_Missense_Mutation_p.K286M|SLC22A11_uc001oak.1_Missense_Mutation_p.K115M	NM_018484	NP_060954	Q9NSA0	S22AB_HUMAN	solute carrier family 22 member 11	286	Cytoplasmic (Potential).				urate metabolic process	apical plasma membrane|external side of plasma membrane|integral to plasma membrane	inorganic anion exchanger activity|protein binding|sodium-independent organic anion transmembrane transporter activity			ovary(1)|central_nervous_system(1)	2					Probenecid(DB01032)	CTGATTATTAAGGGCAAACCA	0.587			NA											26	79					0	0	0.008361	0	0
EHBP1L1	254102	broad.mit.edu	37	11	65349621	65349621	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr11:65349621G>A	uc001oeo.3	+	9	1743	c.1478G>A	c.(1477-1479)GGT>GAT	p.G493D	EHBP1L1_uc001oep.1_Intron	NM_001099409	NP_001092879	Q8N3D4	EH1L1_HUMAN	tangerin	493										central_nervous_system(1)	1						GGGCAACTTGGTGACCTCGAG	0.682			NA											7	25					0	0	0.010729	0	0
MYEOV	26579	broad.mit.edu	37	11	69063518	69063518	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr11:69063518G>T	uc001oov.2	+	3	1051	c.601G>T	c.(601-603)GTG>TTG	p.V201L	MYEOV_uc001oox.2_Intron|MYEOV_uc009ysl.2_Missense_Mutation_p.V201L|MYEOV_uc001oow.2_Missense_Mutation_p.V143L	NM_138768	NP_620123	Q96EZ4	MYEOV_HUMAN	myeloma overexpressed	201											0	all_lung(4;2.21e-19)|Lung NSC(4;6.13e-19)|Melanoma(5;0.00128)		LUSC - Lung squamous cell carcinoma(11;3.33e-11)|STAD - Stomach adenocarcinoma(18;0.00654)|LUAD - Lung adenocarcinoma(13;0.0713)	Kidney(183;2.99e-09)|KIRC - Kidney renal clear cell carcinoma(183;3.23e-08)|Lung(977;0.00361)|LUSC - Lung squamous cell carcinoma(976;0.0153)		GCGAATGGATGTGGCTCTGCG	0.607			NA											74	156					1.37693e-34	2.25735e-34	0.01441	1	0
PRKRIR	5612	broad.mit.edu	37	11	76063505	76063505	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr11:76063505C>A	uc001oxh.1	-	5	689	c.689G>T	c.(688-690)TGT>TTT	p.C230F	PRKRIR_uc010rrz.1_Missense_Mutation_p.C55F	NM_004705	NP_004696	O43422	P52K_HUMAN	protein-kinase, interferon-inducible double	230					negative regulation of cell proliferation|response to stress|signal transduction		DNA binding|metal ion binding|protein dimerization activity			ovary(2)|pancreas(1)	3						TGTTTTTGAACAAAACAACGT	0.438			NA											19	49					1.33986e-20	1.98282e-20	0.004656	1	0
FAT3	120114	broad.mit.edu	37	11	92087733	92087733	+	Missense_Mutation	SNP	A	A	G			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr11:92087733A>G	uc001pdj.3	+	1	2472	c.2455A>G	c.(2455-2457)ATC>GTC	p.I819V		NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	819	Extracellular (Potential).|Cadherin 7.				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				ACTGCTGACCATCAATGTGGA	0.403			NA								TCGA Ovarian(4;0.039)			23	46					0	0	0.003954	0	0
FAT3	120114	broad.mit.edu	37	11	92498063	92498064	+	Missense_Mutation	DNP	GG	GG	TT			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr11:92498063_92498064GG>TT	uc001pdj.3	+	5	4020_4021	c.4003_4004GG>TT	c.(4003-4005)GGG>TTG	p.G1335L		NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	1335	Cadherin 12.|Extracellular (Potential).				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				AGTGGACAATGGGCGCCCACAG	0.485			NA								TCGA Ovarian(4;0.039)			17	39					0	0	0.004672	0	0
DSCAML1	57453	broad.mit.edu	37	11	117395563	117395563	+	Silent	SNP	G	G	A			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr11:117395563G>A	uc001prh.1	-	5	1076	c.1074C>T	c.(1072-1074)AAC>AAT	p.N358N	DSCAML1_uc001pri.1_Silent_p.N162N	NM_020693	NP_065744	Q8TD84	DSCL1_HUMAN	Down syndrome cell adhesion molecule like 1	298	Ig-like C2-type 3.|Extracellular (Potential).				axonogenesis|brain development|cell fate determination|dorsal/ventral pattern formation|embryonic skeletal system morphogenesis|homophilic cell adhesion	cell surface|integral to membrane|plasma membrane	protein homodimerization activity			ovary(3)|large_intestine(2)|skin(2)|upper_aerodigestive_tract(1)	8	all_hematologic(175;0.0487)	Breast(348;0.0424)|Medulloblastoma(222;0.0523)|all_hematologic(192;0.232)		BRCA - Breast invasive adenocarcinoma(274;9.12e-06)|Epithelial(105;0.00172)		AACCGAAGGTGTTGGTGACCT	0.632			NA											4	21					0	0	0.001168	0	0
TECTA	7007	broad.mit.edu	37	11	120996458	120996458	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr11:120996458G>A	uc010rzo.1	+	7	1651	c.1651G>A	c.(1651-1653)GTG>ATG	p.V551M		NM_005422	NP_005413	O75443	TECTA_HUMAN	tectorin alpha precursor	551					cell-matrix adhesion|sensory perception of sound	anchored to membrane|plasma membrane|proteinaceous extracellular matrix				breast(6)|ovary(2)|skin(2)	10	all_hematologic(175;0.208)	Breast(109;0.000766)|Medulloblastoma(222;0.0427)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;8.04e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.166)		GCACAGCTGCGTGTATGACCT	0.567			NA											80	197					0	0	0.01441	0	0
SORL1	6653	broad.mit.edu	37	11	121403215	121403215	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr11:121403215G>A	uc001pxx.2	+	12	1719	c.1639G>A	c.(1639-1641)GGA>AGA	p.G547R		NM_003105	NP_003096	Q92673	SORL_HUMAN	sortilin-related receptor containing LDLR class	547	Extracellular (Potential).				cholesterol metabolic process|lipid transport|receptor-mediated endocytosis	integral to plasma membrane|low-density lipoprotein particle	low-density lipoprotein particle binding|transmembrane receptor activity			ovary(5)|breast(4)|large_intestine(2)|skin(2)|central_nervous_system(1)|pancreas(1)	15		Breast(109;0.00119)|Medulloblastoma(222;0.0429)|all_neural(223;0.113)		BRCA - Breast invasive adenocarcinoma(274;3.34e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.108)		AGACCACGGCGGAATCATCAC	0.483			NA											4	69					0	0	0.009096	0	0
RPL13AP20	387841	broad.mit.edu	37	12	13028826	13028826	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr12:13028826G>A	uc010sho.1	+	1	416	c.394G>A	c.(394-396)GCA>ACA	p.A132T		NR_003932				SubName: Full=Ribosomal protein L13a variant; Flags: Fragment;												0						TCTGAAGCCTGCAAGAAAGTT	0.567			NA											3	19					0	0	0.009096	0	0
KRAS	3845	broad.mit.edu	37	12	25398285	25398285	+	Missense_Mutation	SNP	C	C	A	rs121913530		TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr12:25398285C>A	uc001rgp.1	-	2	215	c.34G>T	c.(34-36)GGT>TGT	p.G12C	KRAS_uc001rgq.1_Missense_Mutation_p.G12C|KRAS_uc001rgr.2_RNA	NM_033360	NP_203524	P01116	RASK_HUMAN	c-K-ras2 protein isoform a precursor	12	GTP.		G -> D (in pancreatic carcinoma, GASC and lung carcinoma; somatic mutation).|G -> R (in lung cancer and bladder cancer; somatic mutation).|G -> S (in lung carcinoma and GASC; somatic mutation).|G -> A (in a colorectal cancer sample; somatic mutation).|G -> C (in lung carcinoma; somatic mutation).|G -> V (in lung carcinoma, pancreatic carcinoma, colon cancer and GASC; somatic mutation).		activation of MAPKK activity|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	plasma membrane	GTP binding|GTPase activity|protein binding	p.G12D(7175)|p.G12V(4780)|p.G12C(2482)|p.G12A(1180)|p.G12S(1119)|p.G12R(691)|p.G12?(50)|p.G12F(34)|p.G12G(6)|p.G12N(6)|p.G12L(5)|p.G12I(4)|p.G12_G13insG(4)|p.G12E(3)|p.G12W(3)|p.A11_G12insGA(2)|p.G12Y(2)|p.G12fs*3(1)		large_intestine(12391)|pancreas(3285)|lung(2847)|biliary_tract(521)|ovary(443)|endometrium(339)|haematopoietic_and_lymphoid_tissue(318)|stomach(203)|thyroid(149)|prostate(85)|soft_tissue(77)|small_intestine(62)|upper_aerodigestive_tract(59)|cervix(49)|urinary_tract(48)|skin(38)|liver(31)|breast(28)|testis(17)|oesophagus(15)|central_nervous_system(9)|peritoneum(6)|salivary_gland(6)|kidney(5)|gastrointestinal_tract_(site_indeterminate)(5)|thymus(5)|eye(4)|autonomic_ganglia(2)|bone(2)|genital_tract(1)|penis(1)|adrenal_gland(1)	21052	all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)		OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)			CCTACGCCACCAGCTCCAACT	0.348	Pancreas(8;6 143 191 305 2070 2426 4376 10944 11745 26467 38091 50869)	G12C(UMUC3_URINARY_TRACT)|G12R(CAL62_THYROID)|G12C(CALU1_LUNG)|G12C(NCIH2030_LUNG)|G12C(LU99_LUNG)|G12C(NCIH1792_LUNG)|G12R(KP2_PANCREAS)|G12C(KHM1B_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12C(NCIH2122_LUNG)|G12C(NCIH358_LUNG)|G12R(PSN1_PANCREAS)|G12C(KYSE410_OESOPHAGUS)|G12S(A549_LUNG)|G12R(HUPT3_PANCREAS)|G12R(TCCPAN2_PANCREAS)|G12C(HCC44_LUNG)|G12S(KMS20_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12C(SW1463_LARGE_INTESTINE)|G12C(NCIH23_LUNG)|G12C(LU65_LUNG)|G12C(NCIH1373_LUNG)|G12C(MIAPACA2_PANCREAS)|G12R(HS274T_BREAST)|G12S(LS123_LARGE_INTESTINE)|G12C(SW1573_LUNG)|G12C(SW837_LARGE_INTESTINE)|G12C(OV56_OVARY)|G12C(IALM_LUNG)	119	Mis		pancreatic|colorectal|lung|thyroid|AML|others				Cardiofaciocutaneous_syndrome|Noonan_syndrome	TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)			6	12					0.000157383	0.000168053	0.00308	1	0
DDX11	1663	broad.mit.edu	37	12	31249591	31249592	+	Missense_Mutation	DNP	GT	GT	TA			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	GT	GT	-	-	GT	GT	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr12:31249591_31249592GT>TA	uc001rjt.1	+	16	1793_1794	c.1542_1543GT>TA	c.(1540-1545)CGGTAC>CGTAAC	p.Y515N	DDX11_uc001rjr.1_Missense_Mutation_p.Y515N|DDX11_uc001rjs.1_Missense_Mutation_p.Y515N|DDX11_uc001rju.1_Missense_Mutation_p.Y193N|DDX11_uc001rjv.1_Missense_Mutation_p.Y515N|DDX11_uc001rjw.1_Missense_Mutation_p.Y489N|DDX11_uc009zjn.1_RNA	NM_152438	NP_689651	Q96FC9	DDX11_HUMAN	DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 11	515					G2/M transition of mitotic cell cycle|interspecies interaction between organisms|mitotic sister chromatid segregation|positive regulation of cell proliferation|S phase of mitotic cell cycle|sister chromatid cohesion	midbody|nuclear chromatin|nucleolus|spindle pole	ATP binding|ATP-dependent DNA helicase activity|DNA binding|protein binding|RNA binding			breast(3)	3	all_cancers(9;1.77e-11)|all_lung(12;6.21e-11)|all_epithelial(9;6.49e-11)|Lung NSC(12;1.06e-08)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0429)|Lung SC(12;0.0592)|Esophageal squamous(101;0.233)					TCACTGAACGGTACGGAGCAGT	0.594			NA								Multiple Myeloma(12;0.14)			21	75					0	0	0.004672	0	0
ARID2	196528	broad.mit.edu	37	12	46245320	46245320	+	Silent	SNP	G	G	T			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr12:46245320G>T	uc001ros.1	+	15	3414	c.3414G>T	c.(3412-3414)GGG>GGT	p.G1138G	ARID2_uc001ror.2_Silent_p.G1138G|ARID2_uc009zkg.1_Silent_p.G594G|ARID2_uc009zkh.1_Silent_p.G765G|ARID2_uc001rou.1_Silent_p.G472G	NM_152641	NP_689854	Q68CP9	ARID2_HUMAN	AT rich interactive domain 2 (ARID, RFX-like)	1138					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(6)|skin(3)|upper_aerodigestive_tract(1)	10	Lung SC(27;0.192)|Renal(347;0.236)	Lung NSC(34;0.106)|all_lung(34;0.22)	OV - Ovarian serous cystadenocarcinoma(5;0.00691)	GBM - Glioblastoma multiforme(48;0.0153)		CACCCTCAGGGGGAGTACAAA	0.512			NA											41	108					2.37825e-27	3.73241e-27	0.010771	1	0
MLL2	8085	broad.mit.edu	37	12	49422684	49422684	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr12:49422684G>A	uc001rta.3	-	45	14309	c.14309C>T	c.(14308-14310)CCT>CTT	p.P4770L		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	4770					chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						AGTTGTGACAGGCAGCTTTCC	0.542			NA	N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			86	231					0	0	0.01441	0	0
DIP2B	57609	broad.mit.edu	37	12	51065097	51065097	+	Missense_Mutation	SNP	T	T	G			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr12:51065097T>G	uc001rwv.2	+	5	712	c.556T>G	c.(556-558)TCA>GCA	p.S186A	DIP2B_uc001rwu.2_Missense_Mutation_p.S186A|DIP2B_uc009zls.1_Missense_Mutation_p.S68A	NM_173602	NP_775873	Q9P265	DIP2B_HUMAN	DIP2 disco-interacting protein 2 homolog B	186	Ser-rich.					nucleus	catalytic activity|transcription factor binding			ovary(4)|breast(1)|pancreas(1)	6						GTCCACTTCTTCATCCGCATC	0.512			NA											37	82					0	0	0.005524	0	0
CCT2	10576	broad.mit.edu	37	12	69983267	69983267	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr12:69983267C>T	uc001svb.1	+	7	543	c.449C>T	c.(448-450)TCC>TTC	p.S150F	CCT2_uc009zrm.1_RNA|CCT2_uc009zrn.1_Missense_Mutation_p.S150F|CCT2_uc010stl.1_Missense_Mutation_p.S103F	NM_006431	NP_006422	P78371	TCPB_HUMAN	chaperonin containing TCP1, subunit 2	150					'de novo' posttranslational protein folding	nucleus	ATP binding|unfolded protein binding			ovary(1)|central_nervous_system(1)|skin(1)	3	all_cancers(2;7.7e-106)|Breast(13;2.15e-06)|Esophageal squamous(21;0.187)		Epithelial(6;2.72e-18)|GBM - Glioblastoma multiforme(2;2.58e-10)|Lung(24;0.000185)|OV - Ovarian serous cystadenocarcinoma(12;0.00126)|STAD - Stomach adenocarcinoma(21;0.00501)|Kidney(9;0.143)|LUSC - Lung squamous cell carcinoma(43;0.24)			TTATTTAGTTCCGATGAAGTT	0.299			NA											5	39					0	0	0.000602	0	0
LGR5	8549	broad.mit.edu	37	12	71978333	71978333	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr12:71978333G>T	uc001swl.2	+	18	2591	c.2543G>T	c.(2542-2544)AGC>ATC	p.S848I	LGR5_uc001swm.2_Missense_Mutation_p.S824I|LGR5_uc001swn.1_RNA	NM_003667	NP_003658	O75473	LGR5_HUMAN	leucine-rich repeat-containing G protein-coupled	848	Cytoplasmic (Potential).					integral to plasma membrane	protein-hormone receptor activity			lung(4)|skin(3)|ovary(1)|pancreas(1)	9						AAACACCCAAGCTTGATGTCA	0.448			NA											36	112					1.06647e-15	1.46515e-15	0.003755	1	0
KCNC2	3747	broad.mit.edu	37	12	75442064	75442064	+	Missense_Mutation	SNP	G	G	A	rs142936560	byFrequency	TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr12:75442064G>A	uc001sxg.1	-	4	2193	c.1649C>T	c.(1648-1650)CCG>CTG	p.P550L	KCNC2_uc009zry.2_Missense_Mutation_p.P550L|KCNC2_uc001sxe.2_Missense_Mutation_p.P550L|KCNC2_uc001sxf.2_Intron|KCNC2_uc010stw.1_Intron	NM_139137	NP_631875	Q96PR1	KCNC2_HUMAN	Shaw-related voltage-gated potassium channel	550	Cytoplasmic (Potential).				energy reserve metabolic process|regulation of insulin secretion	voltage-gated potassium channel complex	voltage-gated potassium channel activity	p.P550L(1)		breast(2)|pancreas(2)|skin(1)|lung(1)	6						TGATAGTGGCGGCTCACTTCC	0.483			NA											9	45					0	0	0.006214	0	0
MYF6	4618	broad.mit.edu	37	12	81101854	81101854	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr12:81101854G>A	uc001szf.1	+	1	409	c.356G>A	c.(355-357)CGA>CAA	p.R119Q		NM_002469	NP_002460	P23409	MYF6_HUMAN	myogenic factor 6	119	Helix-loop-helix motif.				muscle cell fate commitment|positive regulation of muscle cell differentiation|positive regulation of transcription from RNA polymerase II promoter|skeletal muscle tissue development	nucleoplasm	DNA binding|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)	1						CTGAAGCGGCGAACTGTGGCC	0.597			NA											36	101					0	0	0.010771	0	0
HAL	3034	broad.mit.edu	37	12	96374622	96374622	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr12:96374622C>A	uc001tem.1	-	16	1604	c.1307G>T	c.(1306-1308)GGA>GTA	p.G436V	HAL_uc009zti.1_RNA|HAL_uc010suw.1_Missense_Mutation_p.G228V|HAL_uc010sux.1_Missense_Mutation_p.G436V	NM_002108	NP_002099	P42357	HUTH_HUMAN	histidine ammonia-lyase	436					biosynthetic process|histidine catabolic process	cytosol	histidine ammonia-lyase activity			ovary(2)|skin(1)	3					L-Histidine(DB00117)	AACTGTCTCTCCCCTATTGGC	0.423	NSCLC(169;943 2815 23563 30031)		NA											37	114					3.54909e-21	5.28766e-21	0.011902	1	0
GAS2L3	283431	broad.mit.edu	37	12	101005791	101005791	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr12:101005791G>C	uc001thu.2	+	6	543	c.317G>C	c.(316-318)AGA>ACA	p.R106T	GAS2L3_uc009zty.2_Missense_Mutation_p.R106T|GAS2L3_uc001thv.2_Missense_Mutation_p.R2T	NM_174942	NP_777602	Q86XJ1	GA2L3_HUMAN	growth arrest-specific 2 like 3	106	CH.				cell cycle arrest					skin(1)	1						TTTCCAATGAGAAAAGTGCCC	0.348			NA											21	76					0	0	0.010504	0	0
MYO1H	283446	broad.mit.edu	37	12	109841826	109841826	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr12:109841826G>T	uc010sxn.1	+	6	742	c.742G>T	c.(742-744)GAC>TAC	p.D248Y		NM_001101421	NP_001094891	Q8N1T3	MYO1H_HUMAN	myosin 1H	Error:Variant_position_missing_in_B4DNW6_after_alignment						myosin complex	motor activity				0						TGACAAGAATGACTGGAAAAC	0.418			NA											6	27					3.09899e-07	3.54975e-07	0.004482	1	0
MYL2	4633	broad.mit.edu	37	12	111356969	111356969	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr12:111356969C>A	uc001try.3	-	2	103	c.32G>T	c.(31-33)GGG>GTG	p.G11V	MYL2_uc001trx.3_5'UTR	NM_000432	NP_000423	P10916	MLRV_HUMAN	slow cardiac myosin regulatory light chain 2	11					cardiac myofibril assembly|heart contraction|muscle filament sliding|negative regulation of cell growth|regulation of striated muscle contraction|ventricular cardiac muscle tissue morphogenesis	cytosol|myosin complex|sarcomere	actin monomer binding|calcium ion binding|myosin heavy chain binding|structural constituent of muscle			ovary(1)	1						GTTGGCGCCCCCGGCTCTCTT	0.502	GBM(14;268 426 18829 21617 25540)		NA											10	41					6.40141e-05	6.93617e-05	0.010729	1	0
MED13L	23389	broad.mit.edu	37	12	116401214	116401214	+	Missense_Mutation	SNP	T	T	A			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr12:116401214T>A	uc001tvw.2	-	30	6553	c.6498A>T	c.(6496-6498)TTA>TTT	p.L2166F		NM_015335	NP_056150	Q71F56	MD13L_HUMAN	mediator complex subunit 13-like	2166					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent					skin(4)|ovary(2)|upper_aerodigestive_tract(1)|lung(1)	8	all_neural(191;0.117)|Medulloblastoma(191;0.163)			BRCA - Breast invasive adenocarcinoma(302;0.0407)		GTATCTACCTTAAAACATCCG	0.428			NA											22	47					0	0	0.00278	0	0
ATP8A2	51761	broad.mit.edu	37	13	26148945	26148945	+	Splice_Site	SNP	G	G	C			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr13:26148945G>C	uc001uqk.2	+	19	1805	c.1663_splice	c.e19-1	p.M555_splice	ATP8A2_uc010tdi.1_Splice_Site_p.M515_splice|ATP8A2_uc010tdj.1_Splice_Site|ATP8A2_uc010aaj.1_Splice_Site_p.M65_splice	NM_016529	NP_057613	Q9NTI2	AT8A2_HUMAN	ATPase, aminophospholipid transporter-like,						ATP biosynthetic process|negative regulation of cell proliferation	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(2)|large_intestine(1)|skin(1)	4		Breast(139;0.0201)|Lung SC(185;0.0225)		all cancers(112;0.043)|OV - Ovarian serous cystadenocarcinoma(117;0.0748)|Epithelial(112;0.079)		TCTTCCTTTAGATGGGACAGG	0.333			NA											22	41					0	0	0.005443	0	0
POSTN	10631	broad.mit.edu	37	13	38172804	38172804	+	Silent	SNP	G	G	A	rs138966400	byFrequency	TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr13:38172804G>A	uc001uwo.3	-	1	178	c.60C>T	c.(58-60)AAC>AAT	p.N20N	POSTN_uc001uwp.3_Silent_p.N20N|POSTN_uc001uwr.2_Silent_p.N20N|POSTN_uc001uwq.2_Silent_p.N20N|POSTN_uc010teu.1_Silent_p.N20N|POSTN_uc010tev.1_Silent_p.N20N|POSTN_uc010tew.1_Silent_p.N20N|POSTN_uc010tex.1_Intron	NM_006475	NP_006466	Q15063	POSTN_HUMAN	periostin, osteoblast specific factor isoform 1	20					cell adhesion|skeletal system development	proteinaceous extracellular matrix	heparin binding			ovary(2)	2		Lung NSC(96;2.09e-05)|Prostate(109;0.0513)|Breast(139;0.0538)|Lung SC(185;0.0743)		all cancers(112;2.48e-08)|Epithelial(112;2.78e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000853)|BRCA - Breast invasive adenocarcinoma(63;0.013)|GBM - Glioblastoma multiforme(144;0.0154)		GATTGTTGGCGTTTATAGGGT	0.413			NA											8	53					0	0	0.004482	0	0
TNFSF11	8600	broad.mit.edu	37	13	43181007	43181007	+	Nonsense_Mutation	SNP	C	C	T			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr13:43181007C>T	uc001uyu.2	+	5	1056	c.907C>T	c.(907-909)CAG>TAG	p.Q303*	TNFSF11_uc001uyt.2_Nonsense_Mutation_p.Q230*	NM_003701	NP_003692	O14788	TNF11_HUMAN	tumor necrosis factor ligand superfamily, member	303	Extracellular (Potential).				immune response|monocyte chemotaxis|osteoclast differentiation|positive regulation of bone resorption|positive regulation of corticotropin-releasing hormone secretion|positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling|positive regulation of fever generation by positive regulation of prostaglandin secretion|positive regulation of homotypic cell-cell adhesion|positive regulation of NF-kappaB transcription factor activity|positive regulation of osteoclast differentiation|positive regulation of T cell activation	cytoplasm|extracellular space|integral to plasma membrane	cytokine activity|receptor activity|tumor necrosis factor receptor binding				0		Lung NSC(96;1.11e-05)|Breast(139;0.00868)|Prostate(109;0.0181)|Lung SC(185;0.0262)|Hepatocellular(98;0.114)		OV - Ovarian serous cystadenocarcinoma(117;0.000249)|GBM - Glioblastoma multiforme(144;0.00119)|BRCA - Breast invasive adenocarcinoma(63;0.073)		GGATCCGGATCAGGATGCAAC	0.398			NA											49	102					0	0	0.01441	0	0
DIAPH3	81624	broad.mit.edu	37	13	60582753	60582753	+	Silent	SNP	T	T	A			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr13:60582753T>A	uc001vht.2	-	9	1158	c.939A>T	c.(937-939)TCA>TCT	p.S313S	DIAPH3_uc001vhu.2_Silent_p.S50S|DIAPH3_uc001vhw.1_Silent_p.S302S|DIAPH3_uc010aed.1_Silent_p.S267S|DIAPH3_uc010aee.1_Silent_p.S243S	NM_001042517	NP_001035982	Q9NSV4	DIAP3_HUMAN	diaphanous homolog 3 isoform a	313	GBD/FH3.				actin cytoskeleton organization		actin binding|Rho GTPase binding			ovary(2)	2		Breast(118;0.052)|Prostate(109;0.103)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;2.77e-05)		CTTCACCAGCTGAAGTTAAAG	0.328			NA											17	119					0	0	0.006122	0	0
KLHL1	57626	broad.mit.edu	37	13	70413137	70413137	+	Missense_Mutation	SNP	T	T	C			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr13:70413137T>C	uc001vip.2	-	6	2179	c.1385A>G	c.(1384-1386)TAT>TGT	p.Y462C	KLHL1_uc010thm.1_Missense_Mutation_p.Y401C	NM_020866	NP_065917	Q9NR64	KLHL1_HUMAN	kelch-like 1 protein	462	Kelch 1.				actin cytoskeleton organization	cytoplasm|cytoskeleton	actin binding				0		Breast(118;0.000162)		COAD - Colon adenocarcinoma(199;0.000193)|GBM - Glioblastoma multiforme(99;0.000211)		TCCTACAGCATACAAAGTTCC	0.348			NA											4	7					0	0	0.009096	0	0
SLITRK1	114798	broad.mit.edu	37	13	84454289	84454289	+	Silent	SNP	G	G	A			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr13:84454289G>A	uc001vlk.2	-	1	2240	c.1354C>T	c.(1354-1356)CTG>TTG	p.L452L		NM_052910	NP_443142	Q96PX8	SLIK1_HUMAN	slit and trk like 1 protein precursor	452	Extracellular (Potential).|LRR 10.					integral to membrane				ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	5	Medulloblastoma(90;0.18)	Breast(118;0.212)		GBM - Glioblastoma multiforme(99;0.07)		TCCACGTTCAGGTACTCTAGG	0.512			NA											54	139					0	0	0.01441	0	0
SLITRK5	26050	broad.mit.edu	37	13	88330366	88330366	+	Missense_Mutation	SNP	A	A	G			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr13:88330366A>G	uc001vln.2	+	2	2942	c.2723A>G	c.(2722-2724)GAC>GGC	p.D908G	SLITRK5_uc010tic.1_Missense_Mutation_p.D667G	NM_015567	NP_056382	O94991	SLIK5_HUMAN	SLIT and NTRK-like family, member 5 precursor	908	Cytoplasmic (Potential).					integral to membrane				ovary(2)|pancreas(2)|central_nervous_system(1)	5	all_neural(89;0.101)|Medulloblastoma(90;0.163)					GGGGCAGGGGACAGCAGGCTA	0.552			NA											40	251					0	0	0.007835	0	0
NALCN	259232	broad.mit.edu	37	13	101755543	101755543	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr13:101755543C>A	uc001vox.1	-	26	3226	c.3037G>T	c.(3037-3039)GGC>TGC	p.G1013C		NM_052867	NP_443099	Q8IZF0	NALCN_HUMAN	voltage gated channel like 1	1013	Cytoplasmic (Potential).					integral to membrane	sodium channel activity|voltage-gated ion channel activity			ovary(8)|breast(4)|skin(2)|pancreas(1)|central_nervous_system(1)	16	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					TCCTTGAAGCCGCTGAAAAGT	0.453			NA											38	108					8.69298e-16	1.198e-15	0.006999	1	0
RNASE11	122651	broad.mit.edu	37	14	21052268	21052268	+	Silent	SNP	G	G	T			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr14:21052268G>T	uc010ahv.2	-	2	551	c.366C>A	c.(364-366)CGC>CGA	p.R122R	RNASE11_uc010ahx.2_Silent_p.R122R|RNASE11_uc010ahw.2_Silent_p.R122R|RNASE11_uc001vxs.2_Silent_p.R122R	NM_145250	NP_660293	Q8TAA1	RNS11_HUMAN	ribonuclease, RNase A family, 11 (non-active)	122						extracellular region	nucleic acid binding|pancreatic ribonuclease activity			ovary(3)	3	all_cancers(95;0.00238)	all_lung(585;0.235)	Epithelial(56;1.85e-06)|all cancers(55;1.46e-05)	GBM - Glioblastoma multiforme(265;0.0139)		CTGTGGAGCTGCGGATGAAGT	0.488			NA											22	59					0.00188189	0.0019807	0.012319	1	0
CMTM5	116173	broad.mit.edu	37	14	23847613	23847613	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr14:23847613C>A	uc010akm.2	+	2	626	c.182C>A	c.(181-183)GCC>GAC	p.A61D	CMTM5_uc001wjs.2_Missense_Mutation_p.A61D|CMTM5_uc001wjt.2_Missense_Mutation_p.A61D|CMTM5_uc010akn.2_Intron|CMTM5_uc001wju.2_Intron|CMTM5_uc010ako.2_Intron	NM_138460	NP_612469	Q96DZ9	CKLF5_HUMAN	chemokine-like factor superfamily 5 isoform a	61	Helical; (Potential).|MARVEL.				chemotaxis	extracellular space|integral to membrane	cytokine activity				0	all_cancers(95;2e-05)			GBM - Glioblastoma multiforme(265;0.0064)|READ - Rectum adenocarcinoma(4;0.0276)|Colorectal(4;0.0382)		GCCTACATGGCCGCGGCGCTA	0.572			NA											82	137					1.15773e-35	1.9122e-35	0.01441	1	0
FAM158A	51016	broad.mit.edu	37	14	24610337	24610337	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr14:24610337C>G	uc001wmi.2	-	2	340	c.177G>C	c.(175-177)ATG>ATC	p.M59I		NM_016049	NP_057133	Q9Y3B6	F158A_HUMAN	hypothetical protein LOC51016	59											0						CGACCTCCAACATGACGGACA	0.652			NA									OREG0022618	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	55	168					0	0	0.01441	0	0
TSSK4	283629	broad.mit.edu	37	14	24676508	24676508	+	Nonsense_Mutation	SNP	T	T	A			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr14:24676508T>A	uc001wng.2	+	3	765	c.597T>A	c.(595-597)TGT>TGA	p.C199*	TM9SF1_uc010tob.1_Intron|TSSK4_uc001wne.2_Nonsense_Mutation_p.C123*|TSSK4_uc001wnf.2_Nonsense_Mutation_p.C129*|TSSK4_uc001wnh.2_Nonsense_Mutation_p.C209*	NM_174944	NP_777604	Q6SA08	TSSK4_HUMAN	testis-specific serine kinase 4	199	Protein kinase.				cell differentiation|multicellular organismal development|positive regulation of CREB transcription factor activity|spermatogenesis		ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity				0				GBM - Glioblastoma multiforme(265;0.018)		AGACTTACTGTGGCAGCTTTG	0.527			NA											98	201					0	0	0.01441	0	0
STRN3	29966	broad.mit.edu	37	14	31374709	31374709	+	Silent	SNP	T	T	A			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr14:31374709T>A	uc001wqu.2	-	15	2160	c.1944A>T	c.(1942-1944)GTA>GTT	p.V648V	STRN3_uc001wqv.2_Silent_p.V564V|STRN3_uc010tpj.1_RNA	NM_001083893	NP_001077362	Q13033	STRN3_HUMAN	nuclear autoantigen isoform 1	648					negative regulation of estrogen receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|response to estradiol stimulus	cytoplasm|dendrite|Golgi apparatus|neuronal cell body|nucleoplasm|nucleus|plasma membrane|protein complex	armadillo repeat domain binding|calmodulin binding|protein complex binding|protein phosphatase 2A binding|sequence-specific DNA binding transcription factor activity				0	Hepatocellular(127;0.0877)|Breast(36;0.148)		LUAD - Lung adenocarcinoma(48;0.00192)|Lung(238;0.0119)|BRCA - Breast invasive adenocarcinoma(188;0.0805)	GBM - Glioblastoma multiforme(265;0.0124)		TGAAAGAGGTTACCATATGAG	0.368			NA											4	21					0	0	0.001168	0	0
MDGA2	161357	broad.mit.edu	37	14	47504503	47504503	+	Silent	SNP	T	T	A	rs146423621	by1000genomes	TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr14:47504503T>A	uc001wwj.3	-	8	1519	c.1323A>T	c.(1321-1323)CCA>CCT	p.P441P	MDGA2_uc001wwi.3_Silent_p.P212P|MDGA2_uc010ani.2_Intron	NM_001113498	NP_001106970	Q7Z553	MDGA2_HUMAN	MAM domain containing 1 isoform 1	441					spinal cord motor neuron differentiation	anchored to membrane|plasma membrane				ovary(4)|large_intestine(1)|pancreas(1)	6						TCAGATTGGGTGGAACTTGAA	0.373			NA											24	44					0	0	0.003954	0	0
SAV1	60485	broad.mit.edu	37	14	51131974	51131974	+	Missense_Mutation	SNP	T	T	C			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr14:51131974T>C	uc001wyg.1	-	3	619	c.458A>G	c.(457-459)CAT>CGT	p.H153R	SAV1_uc001wyh.1_Missense_Mutation_p.H153R	NM_021818	NP_068590	Q9H4B6	SAV1_HUMAN	WW45 protein	153					hippo signaling cascade	cytoplasm|nucleus	identical protein binding			breast(1)	1	all_epithelial(31;0.000611)|Breast(41;0.0333)					GTAGTCTTCATGTGCACGATC	0.383			NA											17	40					0	0	0.00333	0	0
SPTB	6710	broad.mit.edu	37	14	65216089	65216089	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr14:65216089G>T	uc001xhr.2	-	35	6976	c.6922C>A	c.(6922-6924)CCC>ACC	p.P2308T	SPTB_uc001xhs.2_Missense_Mutation_p.P2308T|SPTB_uc010aqi.2_Missense_Mutation_p.P1004T	NM_001024858	NP_001020029	P11277	SPTB1_HUMAN	spectrin beta isoform a	Error:Variant_position_missing_in_P11277_after_alignment					actin filament capping|axon guidance	cell surface|cytosol|intrinsic to internal side of plasma membrane|protein complex|spectrin|spectrin-associated cytoskeleton	actin filament binding|structural constituent of cytoskeleton			ovary(7)|skin(2)|lung(1)|central_nervous_system(1)	11		all_lung(585;4.15e-09)		all cancers(60;4.33e-34)|OV - Ovarian serous cystadenocarcinoma(108;8.32e-20)|BRCA - Breast invasive adenocarcinoma(234;0.0628)		CTGGCGTCGGGGCCGGAGAGG	0.652			NA											8	9					1.58986e-06	1.79317e-06	0.008291	1	0
ZFP36L1	677	broad.mit.edu	37	14	69256990	69256990	+	Nonsense_Mutation	SNP	C	C	A			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr14:69256990C>A	uc001xkh.1	-	2	407	c.277G>T	c.(277-279)GAA>TAA	p.E93*	ZFP36L1_uc001xki.1_Nonsense_Mutation_p.E93*	NM_004926	NP_004917	Q07352	TISB_HUMAN	butyrate response factor 1	93					regulation of mRNA stability	cytosol|nucleus	DNA binding|mRNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1				all cancers(60;0.00203)|BRCA - Breast invasive adenocarcinoma(234;0.00205)|OV - Ovarian serous cystadenocarcinoma(108;0.0401)		TCGCCCCCTTCCGAGAAGGAG	0.667			NA									OREG0022753	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	11	38					6.50621e-10	8.05966e-10	0.013726	1	0
PCNX	22990	broad.mit.edu	37	14	71514586	71514586	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr14:71514586C>G	uc001xmo.2	+	22	4669	c.4223C>G	c.(4222-4224)CCT>CGT	p.P1408R	PCNX_uc010are.1_Missense_Mutation_p.P1297R|PCNX_uc010arf.1_Missense_Mutation_p.P268R	NM_014982	NP_055797	Q96RV3	PCX1_HUMAN	pecanex-like 1	1408						integral to membrane				ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(12;0.206)	all cancers(60;0.00835)|BRCA - Breast invasive adenocarcinoma(234;0.00951)|OV - Ovarian serous cystadenocarcinoma(108;0.0417)		TTTAGCAGCCCTACATATCAG	0.383			NA											15	48					0	0	0.008871	0	0
NEK9	91754	broad.mit.edu	37	14	75573382	75573382	+	Nonsense_Mutation	SNP	C	C	A			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr14:75573382C>A	uc001xrl.2	-	12	1505	c.1351G>T	c.(1351-1353)GGA>TGA	p.G451*	NEK9_uc001xrk.2_5'UTR	NM_033116	NP_149107	Q8TD19	NEK9_HUMAN	NIMA-related kinase 9	451	RCC1 2.				cell division|mitosis	mitochondrion|nucleus	ATP binding|metal ion binding|protein kinase binding|protein serine/threonine kinase activity			lung(2)|stomach(2)|ovary(1)	5				BRCA - Breast invasive adenocarcinoma(234;0.00718)		TAATCTGATCCGAAGGCATAG	0.468			NA											17	40					1.87028e-06	2.10407e-06	0.012319	1	0
CCDC88C	440193	broad.mit.edu	37	14	91779574	91779574	+	Silent	SNP	C	C	G			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr14:91779574C>G	uc010aty.2	-	15	2685	c.2586G>C	c.(2584-2586)CTG>CTC	p.L862L		NM_001080414	NP_001073883	Q9P219	DAPLE_HUMAN	DVL-binding protein DAPLE	862	Potential.				microtubule cytoskeleton organization|protein destabilization|protein homooligomerization|regulation of protein phosphorylation|Wnt receptor signaling pathway	cytoplasm|insoluble fraction	microtubule binding|PDZ domain binding|protein self-association			ovary(3)	3		all_cancers(154;0.0468)				CAACGGCGGACAGTTTGGCAG	0.622			NA											25	138					0	0	0.007291	0	0
KIAA1409	57578	broad.mit.edu	37	14	94088409	94088409	+	Silent	SNP	A	A	G			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr14:94088409A>G	uc001ybv.1	+	28	4448	c.4365A>G	c.(4363-4365)CTA>CTG	p.L1455L	KIAA1409_uc001ybs.1_Silent_p.L1433L	NM_020818	NP_065869	Q9P2D8	UNC79_HUMAN	hypothetical protein LOC57578	1610						integral to membrane				ovary(10)|skin(4)|large_intestine(3)	17		all_cancers(154;0.0354)|all_epithelial(191;0.216)		Epithelial(152;0.188)		TGATAGATCTATCCTCAGATT	0.463			NA											49	96					0	0	0.01441	0	0
MKRN3	7681	broad.mit.edu	37	15	23811308	23811308	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr15:23811308G>T	uc001ywh.3	+	1	855	c.379G>T	c.(379-381)GCC>TCC	p.A127S	MKRN3_uc001ywi.2_Intron|MKRN3_uc010ayi.1_Missense_Mutation_p.A127S	NM_005664	NP_005655	Q13064	MKRN3_HUMAN	makorin ring finger protein 3	127						ribonucleoprotein complex	ligase activity|nucleic acid binding|zinc ion binding			lung(6)|large_intestine(2)|ovary(2)	10		all_cancers(20;8.44e-25)|all_epithelial(15;3.69e-22)|Lung NSC(15;2.96e-18)|all_lung(15;2.8e-17)|Breast(32;0.000353)|Colorectal(260;0.14)		all cancers(64;3.02e-06)|Epithelial(43;1.94e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0012)		TCGGAAGATGGCCACTGAGGG	0.602			NA											48	87					2.43468e-25	3.7281e-25	0.01441	1	0
HERC2	8924	broad.mit.edu	37	15	28414753	28414754	+	Missense_Mutation	DNP	CC	CC	AA			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr15:28414753_28414754CC>AA	uc001zbj.2	-	66	10211_10212	c.10105_10106GG>TT	c.(10105-10107)GGT>TTT	p.G3369F		NM_004667	NP_004658	O95714	HERC2_HUMAN	hect domain and RLD 2	3369					DNA repair|intracellular protein transport|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	guanyl-nucleotide exchange factor activity|heme binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(4)|lung(4)|skin(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	13		all_lung(180;1.3e-11)|Breast(32;0.000194)|Colorectal(260;0.227)		all cancers(64;3.93e-09)|Epithelial(43;9.99e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0271)|GBM - Glioblastoma multiforme(186;0.0497)|Lung(196;0.199)		ATTACTTGCACCACTTATTTTA	0.376			NA											23	94					0	0	0.004672	0	0
TJP1	7082	broad.mit.edu	37	15	30010701	30010701	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr15:30010701C>A	uc001zcr.2	-	21	4120	c.3645G>T	c.(3643-3645)GAG>GAT	p.E1215D	TJP1_uc010azl.2_Missense_Mutation_p.E1203D|TJP1_uc001zcq.2_Missense_Mutation_p.E1139D|TJP1_uc001zcs.2_Missense_Mutation_p.E1135D	NM_003257	NP_003248	Q07157	ZO1_HUMAN	tight junction protein 1 isoform a	1215					cell-cell junction assembly|cellular component disassembly involved in apoptosis	basolateral plasma membrane|cell-cell adherens junction|Golgi apparatus|tight junction				ovary(4)|central_nervous_system(1)|pancreas(1)	6		all_lung(180;7.48e-11)|Breast(32;0.000153)		all cancers(64;3.29e-10)|Epithelial(43;5.34e-09)|BRCA - Breast invasive adenocarcinoma(123;0.0034)|GBM - Glioblastoma multiforme(186;0.0139)|Lung(196;0.186)		CATGGAGAGGCTCAAAATGAC	0.522	Melanoma(77;681 1843 6309 6570)		NA											13	67					7.93312e-07	9.01677e-07	0.00245	1	0
CEP152	22995	broad.mit.edu	37	15	49030868	49030868	+	Missense_Mutation	SNP	A	A	G			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr15:49030868A>G	uc001zwy.2	-	26	4577	c.4543T>C	c.(4543-4545)TGC>CGC	p.C1515R	CEP152_uc001zwz.2_Missense_Mutation_p.C1571R	NM_014985	NP_055800	O94986	CE152_HUMAN	centrosomal protein 152kDa	1515					centrosome duplication|G2/M transition of mitotic cell cycle	centrosome|cytosol	protein kinase binding			lung(2)	2		all_lung(180;0.0428)		all cancers(107;1.08e-07)|GBM - Glioblastoma multiforme(94;2.32e-06)		CAGCCCAAGCAGTCACTAAGG	0.453			NA											7	30					0	0	0.004482	0	0
COPS2	9318	broad.mit.edu	37	15	49431825	49431825	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr15:49431825C>G	uc001zxf.2	-	4	351	c.272G>C	c.(271-273)AGA>ACA	p.R91T	COPS2_uc001zxh.2_Missense_Mutation_p.R91T|COPS2_uc010ufa.1_Missense_Mutation_p.R27T	NM_004236	NP_004227	P61201	CSN2_HUMAN	COP9 constitutive photomorphogenic homolog	91					cullin deneddylation|transcription from RNA polymerase II promoter	cytoplasm|signalosome	protein binding|signal transducer activity			lung(1)	1		all_lung(180;0.0428)		all cancers(107;1.34e-07)|GBM - Glioblastoma multiforme(94;3.02e-05)		CTGCTTATATCTATTCATCAT	0.289	NSCLC(36;322 1063 10349 30082 48062)|Esophageal Squamous(122;685 1633 15569 21293 52803)		NA											10	55					0	0	0.010729	0	0
SLTM	79811	broad.mit.edu	37	15	59191867	59191867	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr15:59191867C>A	uc002afp.2	-	7	947	c.859G>T	c.(859-861)GCA>TCA	p.A287S	SLTM_uc002afo.2_Missense_Mutation_p.A269S|SLTM_uc002afq.2_Intron|SLTM_uc010bgd.2_Intron|SLTM_uc002afr.1_Missense_Mutation_p.A186S	NM_024755	NP_079031	Q9NWH9	SLTM_HUMAN	modulator of estrogen induced transcription	287					apoptosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleotide binding|RNA binding			ovary(1)	1						GGGCTCTGTGCAATGGCGTCC	0.453			NA											10	93					0.000978159	0.00103198	0.010729	1	0
LOC645752	645752	broad.mit.edu	37	15	78211461	78211461	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr15:78211461C>A	uc010bky.2	-	11	1070	c.306G>T	c.(304-306)GAG>GAT	p.E102D		NR_027024				SubName: Full=GOLGA6 protein; Flags: Fragment;												0						TCTCCTCCTGCTCCTGGAGTC	0.567			NA											57	179					6.3237e-29	1.00677e-28	0.01441	1	0
SYNM	23336	broad.mit.edu	37	15	99673193	99673193	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr15:99673193C>T	uc002bup.2	+	6	4748	c.4628C>T	c.(4627-4629)TCA>TTA	p.S1543L	SYNM_uc002buo.2_Missense_Mutation_p.S1231L|SYNM_uc002buq.2_RNA	NM_145728	NP_663780	O15061	SYNEM_HUMAN	desmuslin isoform A	1543	Tail.|Interaction with DMD and UTRN.				intermediate filament cytoskeleton organization	adherens junction|costamere|intermediate filament|neurofilament cytoskeleton	intermediate filament binding|structural constituent of cytoskeleton|structural constituent of muscle|vinculin binding			ovary(3)|central_nervous_system(1)	4						TCGGTGATTTCAGATGAAAAG	0.468	Pancreas(125;1071 1762 21750 40003 40381)		NA											6	39					0	0	0.001168	0	0
ASB7	140460	broad.mit.edu	37	15	101170138	101170138	+	Silent	SNP	C	C	T			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr15:101170138C>T	uc002bwk.2	+	5	1477	c.708C>T	c.(706-708)TAC>TAT	p.Y236Y	ASB7_uc002bwj.2_Silent_p.Y236Y	NM_198243	NP_937886	Q9H672	ASB7_HUMAN	ankyrin repeat and SOCS box-containing protein 7	236	ANK 7.				intracellular signal transduction					skin(1)	1	Lung NSC(78;0.00121)|all_lung(78;0.00152)|Melanoma(26;0.00852)		OV - Ovarian serous cystadenocarcinoma(32;0.00168)|LUSC - Lung squamous cell carcinoma(107;0.0766)|Lung(145;0.103)			TATATAATTACGGAGCAGACA	0.453			NA											16	86					0	0	0.014323	0	0
OR4F15	390649	broad.mit.edu	37	15	102358761	102358761	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr15:102358761G>A	uc010uts.1	+	1	372	c.372G>A	c.(370-372)ATG>ATA	p.M124I		NM_001001674	NP_001001674	Q8NGB8	O4F15_HUMAN	olfactory receptor, family 4, subfamily F,	124	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	Lung NSC(78;0.000991)|all_lung(78;0.00128)|Melanoma(26;0.00505)		OV - Ovarian serous cystadenocarcinoma(32;0.00039)|Lung(145;0.17)|LUSC - Lung squamous cell carcinoma(107;0.187)			ACAGATACATGGCCATATGTA	0.468			NA											16	105					0	0	0.007413	0	0
RHBDL1	9028	broad.mit.edu	37	16	727062	727062	+	Missense_Mutation	SNP	A	A	C			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr16:727062A>C	uc002cis.1	+	3	740	c.713A>C	c.(712-714)CAC>CCC	p.H238P	RHBDL1_uc002cir.1_Missense_Mutation_p.H173P|RHBDL1_uc010uun.1_Missense_Mutation_p.H173P	NM_003961	NP_003952	O75783	RHBL1_HUMAN	rhomboid protease 1	238					proteolysis|signal transduction	integral to plasma membrane|membrane fraction	calcium ion binding|serine-type endopeptidase activity				0		Hepatocellular(780;0.0218)				CTTGTGTACCACCCCGGGCAC	0.637			NA											4	111					0	0	0.00245	0	0
CACNA1H	8912	broad.mit.edu	37	16	1250434	1250434	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr16:1250434G>A	uc002cks.2	+	7	1230	c.982G>A	c.(982-984)GAG>AAG	p.E328K	CACNA1H_uc002ckt.2_Missense_Mutation_p.E328K	NM_021098	NP_066921	O95180	CAC1H_HUMAN	calcium channel, voltage-dependent, T type,	328	Extracellular (Potential).|I.				aldosterone biosynthetic process|axon guidance|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|muscle contraction|myoblast fusion|positive regulation of acrosome reaction|regulation of heart contraction	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(2)	2		Hepatocellular(780;0.00369)			Flunarizine(DB04841)|Mibefradil(DB01388)	GCCGCAGGCCGAGGGGGTGGG	0.667			NA											11	24					0	0	0.00245	0	0
MYH11	4629	broad.mit.edu	37	16	15820896	15820896	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr16:15820896C>T	uc002ddy.2	-	28	3774	c.3667G>A	c.(3667-3669)GAC>AAC	p.D1223N	MYH11_uc002ddv.2_Missense_Mutation_p.D1230N|MYH11_uc002ddw.2_Missense_Mutation_p.D1223N|MYH11_uc002ddx.2_Missense_Mutation_p.D1230N|MYH11_uc010bvg.2_Missense_Mutation_p.D1055N|MYH11_uc010bvh.2_5'Flank	NM_002474	NP_002465	P35749	MYH11_HUMAN	smooth muscle myosin heavy chain 11 isoform	1223	Potential.				axon guidance|cardiac muscle fiber development|elastic fiber assembly|skeletal muscle myosin thick filament assembly|smooth muscle contraction	cytosol|melanosome|muscle myosin complex|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			ovary(6)|skin(3)|lung(2)|breast(2)|upper_aerodigestive_tract(1)|pancreas(1)	15						TTATTCTTGTCTAGGTTCGCC	0.597			NA	T	CBFB	AML								70	509					0	0	0.01441	0	0
ZNF646	9726	broad.mit.edu	37	16	31092791	31092791	+	Silent	SNP	C	C	T			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr16:31092791C>T	uc002eap.2	+	2	5435	c.5146C>T	c.(5146-5148)CTG>TTG	p.L1716L		NM_014699	NP_055514	O15015	ZN646_HUMAN	zinc finger protein 646	1716	C2H2-type 29.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			breast(2)	2						TCTCCCTAACCTGCTGTCTCT	0.632			NA											47	355					0	0	0.01441	0	0
ZNF646	9726	broad.mit.edu	37	16	31092914	31092914	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr16:31092914C>T	uc002eap.2	+	2	5558	c.5269C>T	c.(5269-5271)CGG>TGG	p.R1757W		NM_014699	NP_055514	O15015	ZN646_HUMAN	zinc finger protein 646	1757					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			breast(2)	2						CCATGCACCCCGGGAGGGGCC	0.692			NA											19	121					0	0	0.007413	0	0
PRSS36	146547	broad.mit.edu	37	16	31154786	31154786	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr16:31154786C>A	uc002ebd.2	-	8	1036	c.977G>T	c.(976-978)GGG>GTG	p.G326V	PRSS36_uc010vff.1_Missense_Mutation_p.G101V|PRSS36_uc010vfg.1_Missense_Mutation_p.G326V|PRSS36_uc010vfh.1_Missense_Mutation_p.G326V	NM_173502	NP_775773	Q5K4E3	POLS2_HUMAN	protease, serine, 36 precursor	326	Peptidase S1 2.				proteolysis	cytoplasm|proteinaceous extracellular matrix	serine-type endopeptidase activity			ovary(1)	1						CGGGGCCTTCCCGCACTCTGA	0.657			NA											56	114					1.19403e-26	1.86727e-26	0.01441	1	0
ARMC5	79798	broad.mit.edu	37	16	31476156	31476156	+	Silent	SNP	T	T	C			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr16:31476156T>C	uc002ecc.2	+	4	2341	c.1812T>C	c.(1810-1812)GAT>GAC	p.D604D	ARMC5_uc010vfn.1_Silent_p.D699D|ARMC5_uc010vfo.1_Silent_p.D636D|ARMC5_uc002eca.3_Silent_p.D604D|ARMC5_uc010vfp.1_Silent_p.D412D|ARMC5_uc002ecb.2_Silent_p.D604D	NM_001105247	NP_001098717	Q96C12	ARMC5_HUMAN	armadillo repeat containing 5 isoform a	604							binding			pancreas(1)	1						CGCCTGACGATTGGCCGGCAC	0.701			NA											8	10					0	0	0.013537	0	0
CES4	51716	broad.mit.edu	37	16	55806304	55806304	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr16:55806304G>A	uc002eik.2	+	5	606	c.155G>A	c.(154-156)GGG>GAG	p.G52E	CES4_uc010cce.2_Missense_Mutation_p.G52E	NR_003276				RecName: Full=Inactive carboxylesterase 4; AltName: Full=Placental carboxylesterase 3;          Short=PCE-3; Flags: Precursor;												0						CACAGCCCGGGGAACTGGGGT	0.587			NA											15	12					0	0	0.008871	0	0
MTSS1L	92154	broad.mit.edu	37	16	70712199	70712199	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr16:70712199G>A	uc002ezj.2	-	8	840	c.580C>T	c.(580-582)CGG>TGG	p.R194W	MTSS1L_uc002ezk.1_Missense_Mutation_p.R111W	NM_138383	NP_612392	Q765P7	MTSSL_HUMAN	metastasis suppressor 1-like	194	IMD.				filopodium assembly|signal transduction		actin binding|cytoskeletal adaptor activity|SH3 domain binding			central_nervous_system(1)	1						AAGCGGCCCCGCTCCTCGATC	0.672			NA											17	193					0	0	0.014323	0	0
ZNF19	7567	broad.mit.edu	37	16	71512893	71512893	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr16:71512893C>G	uc010cgc.1	-	4	555	c.49G>C	c.(49-51)GAG>CAG	p.E17Q	ZNF23_uc002fai.2_5'UTR|ZNF19_uc002fak.1_Missense_Mutation_p.E5Q|ZNF19_uc002fal.1_Missense_Mutation_p.E5Q|ZNF19_uc002fam.1_Missense_Mutation_p.E17Q	NM_006961	NP_008892	P17023	ZNF19_HUMAN	zinc finger protein 19	17	KRAB.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Ovarian(137;0.00965)		BRCA - Breast invasive adenocarcinoma(221;0.0161)|Kidney(780;0.0598)		GCCACATCCTCGAAGGTCACC	0.562			NA											21	150					0	0	0.003954	0	0
BCMO1	53630	broad.mit.edu	37	16	81320986	81320986	+	Silent	SNP	G	G	A			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr16:81320986G>A	uc002fgn.1	+	10	1607	c.1389G>A	c.(1387-1389)GCG>GCA	p.A463A	BCMO1_uc010vnp.1_Silent_p.A394A	NM_017429	NP_059125	Q9HAY6	BCDO1_HUMAN	beta-carotene 15,15'-monooxygenase	463					retinoid metabolic process|steroid metabolic process	cytosol	beta-carotene 15,15'-monooxygenase activity|metal ion binding|monooxygenase activity				0						TTGTGCCCGCGCCAGGTGCCA	0.517			NA											59	102					0	0	0.01441	0	0
GAN	8139	broad.mit.edu	37	16	81388292	81388292	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr16:81388292G>T	uc002fgo.2	+	3	713	c.565G>T	c.(565-567)GTT>TTT	p.V189F		NM_022041	NP_071324	Q9H2C0	GAN_HUMAN	gigaxonin	189	BACK.				cell death	cytoplasm|neurofilament	protein binding			ovary(2)	2		Colorectal(91;0.153)				GAAGTTAAACGTTGGCAATGA	0.383	GBM(106;1239 1507 7582 9741 33976)		NA											83	63					4.64247e-43	7.87434e-43	0.01441	1	0
DULLARD	23399	broad.mit.edu	37	17	7150664	7150664	+	Splice_Site	SNP	T	T	A			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr17:7150664T>A	uc002gfd.2	-	2	483	c.103_splice	c.e2-1	p.V35_splice	DULLARD_uc002gfe.2_Splice_Site_p.V35_splice|DULLARD_uc002gff.2_Splice_Site_p.V35_splice|DULLARD_uc002gfc.2_Splice_Site	NM_001143775	NP_001137247	O95476	CNEP1_HUMAN	dullard homolog						nuclear envelope organization|protein dephosphorylation	endoplasmic reticulum membrane|integral to membrane|nuclear membrane	protein serine/threonine phosphatase activity				0						CTGAATTACCTACAAATAGCA	0.353			NA											27	34					0	0	0.004656	0	0
NLGN2	57555	broad.mit.edu	37	17	7317981	7317981	+	Splice_Site	SNP	G	G	T			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr17:7317981G>T	uc002ggt.1	+	4	732	c.659_splice	c.e4-1	p.G220_splice		NM_020795	NP_065846	Q8NFZ4	NLGN2_HUMAN	neuroligin 2 precursor						cell-cell junction maintenance|neuron cell-cell adhesion|positive regulation of synaptogenesis|regulation of inhibitory postsynaptic membrane potential|synapse assembly	cell surface|integral to plasma membrane|postsynaptic membrane	neurexin binding|receptor activity			central_nervous_system(1)	1		Prostate(122;0.157)				TCTACTCCCAGGTTTTCTCAG	0.607			NA											68	120					1.25089e-41	2.0975e-41	0.01441	1	0
C17orf68	80169	broad.mit.edu	37	17	8141519	8141519	+	Silent	SNP	C	C	A			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr17:8141519C>A	uc002gkq.3	-	4	536	c.477G>T	c.(475-477)CTG>CTT	p.L159L	C17orf68_uc010cnv.2_RNA	NM_025099	NP_079375	Q2NKJ3	CTC1_HUMAN	alpha accessory factor 132	159					positive regulation of DNA replication|telomere maintenance	Stn1-Ten1 complex	protein binding|single-stranded DNA binding				0						AACGGGGGAACAGAAAAAGAT	0.532			NA											23	91					1.42536e-11	1.8326e-11	0.004656	1	0
MYH1	4619	broad.mit.edu	37	17	10403991	10403991	+	Silent	SNP	G	G	A			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr17:10403991G>A	uc002gmo.2	-	28	3911	c.3817C>T	c.(3817-3819)CTG>TTG	p.L1273L	uc002gml.1_Intron	NM_005963	NP_005954	P12882	MYH1_HUMAN	myosin, heavy chain 1, skeletal muscle, adult	1273	Potential.					muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			ovary(10)|skin(6)|breast(3)|upper_aerodigestive_tract(1)|kidney(1)	21						TCATTGATCAGCCGCTGCTGC	0.483			NA											29	62					0	0	0.012213	0	0
C17orf48	56985	broad.mit.edu	37	17	10608454	10608454	+	Nonsense_Mutation	SNP	C	C	T			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr17:10608454C>T	uc002gmt.2	+	2	286	c.211C>T	c.(211-213)CAG>TAG	p.Q71*	C17orf48_uc002gmu.2_RNA|C17orf48_uc002gmv.2_RNA|C17orf48_uc010vvg.1_Nonsense_Mutation_p.Q71*	NM_020233	NP_064618	Q3LIE5	ADPRM_HUMAN	ADP-ribose/CDP-alcohol pyrophosphatase	71							ADP-ribose diphosphatase activity|CDP-glycerol diphosphatase activity|metal ion binding				0						TTGTGTCCTTCAGCTTGGAGA	0.433			NA											35	68					0	0	0.010771	0	0
ZNF286A	57335	broad.mit.edu	37	17	15620368	15620368	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr17:15620368G>T	uc010cot.2	+	6	1726	c.1330G>T	c.(1330-1332)GGG>TGG	p.G444W	ZNF286A_uc002goz.3_Missense_Mutation_p.G332W|ZNF286A_uc010vwa.1_Missense_Mutation_p.G444W|ZNF286A_uc002gpa.2_Missense_Mutation_p.G444W	NM_001130842	NP_001124314	Q9HBT8	Z286A_HUMAN	zinc finger protein 286	444	C2H2-type 8.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)	1				UCEC - Uterine corpus endometrioid carcinoma (92;0.0822)|READ - Rectum adenocarcinoma(1115;0.0222)|BRCA - Breast invasive adenocarcinoma(8;0.0781)		TAATGAATGTGGGAAAACCTT	0.393			NA											9	34					1.76689e-08	2.10595e-08	0.006214	1	0
MYO15A	51168	broad.mit.edu	37	17	18023558	18023558	+	Nonsense_Mutation	SNP	C	C	T			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr17:18023558C>T	uc010vxh.1	+	2	1782	c.1444C>T	c.(1444-1446)CGA>TGA	p.R482*		NM_016239	NP_057323	Q9UKN7	MYO15_HUMAN	myosin XV	482	Myosin head-like.				sensory perception of sound	cytoplasm|myosin complex|stereocilium	actin binding|ATP binding|calmodulin binding|motor activity			skin(4)|ovary(2)|pancreas(1)|breast(1)|central_nervous_system(1)	9	all_neural(463;0.228)					CCTCTTCCCGCGACCCCAGGT	0.632			NA											29	46					0	0	0.013726	0	0
CYTSB	92521	broad.mit.edu	37	17	20217341	20217341	+	Missense_Mutation	SNP	A	A	T			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr17:20217341A>T	uc002gwq.2	+	15	3315	c.3170A>T	c.(3169-3171)CAG>CTG	p.Q1057L	CYTSB_uc002gws.2_Missense_Mutation_p.Q1057L|CYTSB_uc002gwv.2_Missense_Mutation_p.Q976L|CYTSB_uc010vzf.1_Missense_Mutation_p.Q397L|CYTSB_uc002gww.2_Missense_Mutation_p.Q794L	NM_001033553	NP_001028725	Q5M775	CYTSB_HUMAN	spectrin domain with coiled-coils 1 NSP5b3b	1057	CH.					nucleus					0						AGTGTGATGCAGTACGTGGCC	0.572			NA											17	28					0	0	0.00499	0	0
SUPT6H	6830	broad.mit.edu	37	17	27011938	27011938	+	Nonsense_Mutation	SNP	A	A	T			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr17:27011938A>T	uc002hby.2	+	19	2536	c.2446A>T	c.(2446-2448)AAA>TAA	p.K816*	SUPT6H_uc010crt.2_Nonsense_Mutation_p.K816*	NM_003170	NP_003161	Q7KZ85	SPT6H_HUMAN	suppressor of Ty 6 homolog	816					chromatin remodeling|regulation of transcription elongation, DNA-dependent|regulation of transcription from RNA polymerase II promoter	nucleus	hydrolase activity, acting on ester bonds|RNA binding|sequence-specific DNA binding transcription factor activity			ovary(2)|skin(1)	3	Lung NSC(42;0.00431)					CCATTTTACCAAACGGCGAAC	0.493			NA											47	49					0	0	0.01441	0	0
FNDC8	54752	broad.mit.edu	37	17	33448781	33448781	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr17:33448781C>A	uc002hix.2	+	1	151	c.69C>A	c.(67-69)AAC>AAA	p.N23K	RFFL_uc002hiq.2_5'Flank|RAD51L3_uc002hir.2_5'Flank|RAD51L3_uc010wcd.1_5'Flank|RAD51L3_uc002his.2_5'Flank|RAD51L3_uc010ctk.2_5'Flank|RAD51L3_uc010wce.1_5'Flank|RAD51L3_uc002hit.2_5'Flank|RAD51L3_uc002hiu.2_5'Flank|RAD51L3_uc010wcf.1_5'Flank|RAD51L3_uc002hiw.1_5'Flank|RAD51L3_uc002hiv.1_5'Flank|RAD51L3_uc010ctl.1_5'Flank|RAD51L3_uc010ctm.1_5'Flank	NM_017559	NP_060029	Q8TC99	FNDC8_HUMAN	fibronectin type III domain containing 8	23										ovary(2)	2		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.022)		AAAACTTCAACATGATGAATG	0.502			NA											18	159					0.00074312	0.00078589	0.006122	1	0
CCL23	6368	broad.mit.edu	37	17	34340789	34340789	+	Silent	SNP	A	A	C			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr17:34340789A>C	uc002hkt.1	-	3	317	c.246T>G	c.(244-246)GGT>GGG	p.G82G	CCL23_uc002hks.1_Silent_p.G99G	NM_145898	NP_665905	P55773	CCL23_HUMAN	small inducible cytokine A23 isoform CKbeta8	82					cell-cell signaling|cellular calcium ion homeostasis|chemotaxis|G-protein coupled receptor protein signaling pathway|immune response|inflammatory response|negative regulation of cell proliferation	extracellular space	chemokine activity|heparin binding				0		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)	Treprostinil(DB00374)	CCTACATGACACCCGGCTTGG	0.542			NA											15	60					0	0	0.00499	0	0
KRT33B	3884	broad.mit.edu	37	17	39521447	39521447	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr17:39521447G>T	uc002hwl.2	-	5	901	c.856C>A	c.(856-858)CTG>ATG	p.L286M		NM_002279	NP_002270	Q14525	KT33B_HUMAN	type I hair keratin 3B	286	Coil 2.|Rod.					intermediate filament	protein binding|structural molecule activity				0		Breast(137;0.000496)				TGGGCCTGCAGCTCGATCTCC	0.592			NA											45	176					2.23044e-30	3.58986e-30	0.01441	1	0
BECN1	8678	broad.mit.edu	37	17	40966604	40966604	+	Silent	SNP	A	A	G			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr17:40966604A>G	uc002ibo.3	-	9	1053	c.918T>C	c.(916-918)GCT>GCC	p.A306A	BECN1_uc010whb.1_Silent_p.A219A|BECN1_uc010whc.1_Silent_p.A230A|BECN1_uc002ibn.2_Silent_p.A306A	NM_003766	NP_003757	Q14457	BECN1_HUMAN	beclin 1	306					anti-apoptosis|cell cycle|cellular defense response|cytokinesis|response to virus	membrane	protein binding			ovary(1)	1		Breast(137;0.00104)		BRCA - Breast invasive adenocarcinoma(366;0.0745)		TCTGGCCCCAAGCAGCATTAA	0.512			NA											28	91					0	0	0.00632	0	0
Unknown	0	broad.mit.edu	37	17	45127206	45127206	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr17:45127206G>C	uc010wkj.1	+	2	758	c.404G>C	c.(403-405)AGA>ACA	p.R135T	uc010wkl.1_RNA					SubName: Full=Putative uncharacterized protein LRRC37A3;												NA						GTGAGAGACAGATGGAAAGAC	0.458			NA											61	135					0	0	0.01441	0	0
HOXB4	3214	broad.mit.edu	37	17	46655326	46655326	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr17:46655326G>T	uc002inp.2	-	1	418	c.356C>A	c.(355-357)CCG>CAG	p.P119Q	HOXB3_uc010wlm.1_Intron|HOXB3_uc010dbf.2_Intron|HOXB3_uc010dbg.2_Intron|HOXB3_uc010wlk.1_5'Flank|HOXB3_uc010wll.1_Intron	NM_024015	NP_076920	P17483	HXB4_HUMAN	homeobox B4	119	Pro-rich (part of the transcriptional activation domain).					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1						GCAGGGAGGCGGCGGGGGGCT	0.731			NA											13	60					6.31663e-08	7.46818e-08	0.003163	1	0
GIP	2695	broad.mit.edu	37	17	47041781	47041781	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr17:47041781G>A	uc002iol.1	-	3	246	c.148C>T	c.(148-150)CCC>TCC	p.P50S		NM_004123	NP_004114	P09681	GIP_HUMAN	gastric inhibitory polypeptide preproprotein	50					energy reserve metabolic process|signal transduction	extracellular region|soluble fraction	hormone activity			skin(1)	1						GCGTACCTGGGGCCTCGAGGT	0.567			NA											22	177					0	0	0.014323	0	0
NGFR	4804	broad.mit.edu	37	17	47583901	47583901	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr17:47583901C>A	uc002ioz.3	+	3	574	c.449C>A	c.(448-450)CCC>CAC	p.P150H		NM_002507	NP_002498	P08138	TNR16_HUMAN	nerve growth factor receptor precursor	150	Extracellular (Potential).|TNFR-Cys 4.				anti-apoptosis|apoptosis|induction of apoptosis by extracellular signals|membrane protein intracellular domain proteolysis|negative regulation of axonogenesis|negative regulation of cell cycle|nerve growth factor receptor signaling pathway|positive regulation of axonogenesis	cell surface|cytosol|endosome|extracellular region|integral to plasma membrane|nucleoplasm				ovary(1)|lung(1)	2	all_cancers(4;1.45e-13)|Breast(4;6.34e-28)|all_epithelial(4;4.95e-17)					GAGGAGTGCCCCGACGGCACG	0.701			NA											8	56					1.12685e-05	1.24547e-05	0.004482	1	0
BCAS3	54828	broad.mit.edu	37	17	59445833	59445833	+	Silent	SNP	G	G	T			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr17:59445833G>T	uc002iyv.3	+	24	2725	c.2616G>T	c.(2614-2616)CGG>CGT	p.R872R	BCAS3_uc002iyu.3_Silent_p.R857R|BCAS3_uc002iyw.3_Silent_p.R853R|BCAS3_uc002iyy.3_Silent_p.R628R|BCAS3_uc002iyz.3_Silent_p.R426R|BCAS3_uc002iza.3_Silent_p.R411R|BCAS3_uc002izb.3_RNA|BCAS3_uc002izc.3_RNA|BCAS3_uc002izd.3_5'UTR	NM_001099432	NP_001092902	Q9H6U6	BCAS3_HUMAN	breast carcinoma amplified sequence 3 isoform 1	872						nucleus				ovary(2)|central_nervous_system(2)|skin(1)	5			BRCA - Breast invasive adenocarcinoma(1;3.11e-12)|Epithelial(12;8.2e-07)|all cancers(12;5.33e-06)			CACCTAGCCGGGACGTCGTGG	0.612			NA											10	47					3.99206e-14	5.38378e-14	0.007413	1	0
ICAM2	3384	broad.mit.edu	37	17	62081303	62081303	+	Missense_Mutation	SNP	A	A	T			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr17:62081303A>T	uc002jdu.3	-	3	582	c.350T>A	c.(349-351)CTG>CAG	p.L117Q	C17orf72_uc002jdt.3_3'UTR|C17orf72_uc010wpu.1_3'UTR|C17orf72_uc010wpv.1_3'UTR|C17orf72_uc010wpw.1_3'UTR|ICAM2_uc002jdw.3_Missense_Mutation_p.L117Q|ICAM2_uc010ded.2_Missense_Mutation_p.L117Q|ICAM2_uc002jdx.3_Missense_Mutation_p.L117Q|ICAM2_uc002jdv.3_Missense_Mutation_p.L117Q	NM_000873	NP_000864	P13598	ICAM2_HUMAN	intercellular adhesion molecule 2 precursor	117	Extracellular (Potential).				cell-cell adhesion|regulation of immune response	integral to plasma membrane	integrin binding			ovary(1)	1						TTGCAGTGTCAGGATGACCTG	0.637			NA											4	60					0	0	0.009096	0	0
GPS1	2873	broad.mit.edu	37	17	80011904	80011904	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr17:80011904G>A	uc002kdl.1	+	3	332	c.287G>A	c.(286-288)CGC>CAC	p.R96H	RFNG_uc002kdj.2_5'Flank|GPS1_uc002kdk.1_Missense_Mutation_p.R136H|GPS1_uc010dij.1_Missense_Mutation_p.R136H|GPS1_uc002kdm.1_Missense_Mutation_p.R80H|GPS1_uc002kdn.1_Missense_Mutation_p.R96H|GPS1_uc002kdo.1_Missense_Mutation_p.R96H|GPS1_uc010wvh.1_Missense_Mutation_p.R88H	NM_004127	NP_004118	Q13098	CSN1_HUMAN	G protein pathway suppressor 1 isoform 2	96					cell cycle|cullin deneddylation|inactivation of MAPK activity|JNK cascade	cytoplasm|signalosome	GTPase inhibitor activity|protein binding			central_nervous_system(1)	1	all_neural(118;0.0878)|Ovarian(332;0.227)|all_lung(278;0.246)		BRCA - Breast invasive adenocarcinoma(99;0.0114)|OV - Ovarian serous cystadenocarcinoma(97;0.0211)			GAGATCCACCGCAAGCTCTCA	0.632			NA											25	21					0	0	0.008361	0	0
KIAA1012	22878	broad.mit.edu	37	18	29446938	29446938	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr18:29446938C>A	uc002kxc.3	-	18	2828	c.2464G>T	c.(2464-2466)GCA>TCA	p.A822S	KIAA1012_uc002kxb.3_Missense_Mutation_p.A768S|KIAA1012_uc002kxd.3_RNA	NM_014939	NP_055754	Q9Y2L5	TPPC8_HUMAN	hypothetical protein LOC22878	822					ER to Golgi vesicle-mediated transport	cis-Golgi network					0						TTTAGTCTTGCCTGTGGAGAT	0.358			NA											15	20					2.23348e-06	2.50628e-06	0.004007	1	0
CDH7	1005	broad.mit.edu	37	18	63511297	63511297	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr18:63511297G>T	uc002ljz.2	+	7	1556	c.1231G>T	c.(1231-1233)GTG>TTG	p.V411L	CDH7_uc002lka.2_Missense_Mutation_p.V411L|CDH7_uc002lkb.2_Missense_Mutation_p.V411L	NM_033646	NP_387450	Q9ULB5	CADH7_HUMAN	cadherin 7, type 2 preproprotein	411	Extracellular (Potential).|Cadherin 4.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)|pancreas(1)|skin(1)	4		Esophageal squamous(42;0.129)				CAATAGCCCTGTGAGGTAAAA	0.423			NA											9	53					3.09899e-07	3.54975e-07	0.004482	1	0
TRIP10	9322	broad.mit.edu	37	19	6750571	6750571	+	Silent	SNP	G	G	A			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr19:6750571G>A	uc002mfs.2	+	14	1650	c.1584G>A	c.(1582-1584)ACG>ACA	p.T528T	TRIP10_uc010dux.1_Silent_p.T472T|TRIP10_uc002mfr.2_Silent_p.T472T|TRIP10_uc010duy.2_RNA|TRIP10_uc010duz.2_Silent_p.T291T	NM_004240	NP_004231	Q15642	CIP4_HUMAN	thyroid hormone receptor interactor 10	528	Interaction with CDC42.|Interaction with PDE6G (By similarity).|Interaction with DNM2 and WASL (By similarity).|Required for interaction with FASLG and localization to lysosomes.				actin cytoskeleton organization|cell communication|endocytosis|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cell cortex|cell projection|cytoskeleton|cytosol|Golgi apparatus|lysosome|perinuclear region of cytoplasm|phagocytic cup	GTPase activator activity|identical protein binding|lipid binding			ovary(1)	1						CCATTTACACGGAGTTTGATG	0.557			NA											18	126					0	0	0.010504	0	0
MUC16	94025	broad.mit.edu	37	19	9062932	9062932	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr19:9062932G>T	uc002mkp.2	-	3	24718	c.24514C>A	c.(24514-24516)CTC>ATC	p.L8172I		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	8174	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GACACTGTGAGCTGAGCAAAG	0.502			NA											42	108					2.37825e-27	3.73241e-27	0.010771	1	0
ZNF490	57474	broad.mit.edu	37	19	12719994	12719994	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr19:12719994C>T	uc002mtz.2	-	2	269	c.140G>A	c.(139-141)GGA>GAA	p.G47E	ZNF791_uc002mua.2_5'Flank|ZNF791_uc010xml.1_5'Flank|ZNF791_uc010dyu.1_5'Flank|ZNF791_uc010xmm.1_5'Flank	NM_020714	NP_065765	Q9ULM2	ZN490_HUMAN	zinc finger protein 490	47					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						GATGCTTTGTCCATGGTGTTC	0.418			NA											16	41					0	0	0.012319	0	0
ZNF208	7757	broad.mit.edu	37	19	22154366	22154366	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr19:22154366C>A	uc002nqp.2	-	6	3235	c.3086G>T	c.(3085-3087)AGT>ATT	p.S1029I	ZNF208_uc002nqo.1_Intron	NM_007153	NP_009084			zinc finger protein 208											ovary(5)|skin(2)	7		all_lung(12;0.0961)|Lung NSC(12;0.103)				CTTATGATAACTAAGGGTTGA	0.358			NA											8	20					1.06961e-07	1.25119e-07	0.00308	1	0
RPSAP58	388524	broad.mit.edu	37	19	24010122	24010122	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr19:24010122G>C	uc002nrn.2	+	4	582	c.159G>C	c.(157-159)AGG>AGC	p.R53S		NM_002295	NP_002286			ribosomal protein SA												0						ATCTCAAGAGGACCTGGGAGA	0.468			NA											6	54					0	0	0.006214	0	0
RPSAP58	388524	broad.mit.edu	37	19	24010315	24010315	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr19:24010315G>A	uc002nrn.2	+	4	775	c.352G>A	c.(352-354)GAG>AAG	p.E118K		NM_002295	NP_002286			ribosomal protein SA												0						AGCCTTCTGGGAGCCACGGCT	0.562			NA											8	48					0	0	0.003163	0	0
POP4	10775	broad.mit.edu	37	19	30102776	30102776	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr19:30102776C>G	uc002nsf.2	+	4	348	c.292C>G	c.(292-294)CTT>GTT	p.L98V	POP4_uc002nsg.2_Missense_Mutation_p.L17V	NM_006627	NP_006618	O95707	RPP29_HUMAN	processing of precursor 4	98					mRNA cleavage|rRNA processing|tRNA processing	nucleolar ribonuclease P complex|ribonuclease MRP complex	identical protein binding|ribonuclease P activity|RNA binding				0	Ovarian(5;0.000567)|Breast(6;0.0602)|Esophageal squamous(110;0.239)		UCEC - Uterine corpus endometrioid carcinoma (4;2.65e-06)|STAD - Stomach adenocarcinoma(5;1.7e-06)|Lung(7;0.0623)|LUAD - Lung adenocarcinoma(5;0.0989)|BRCA - Breast invasive adenocarcinoma(6;0.225)			CAGATACAGCCTTTTCCTCCC	0.463	Melanoma(89;1165 1449 14085 34436 43672)		NA											47	130					0	0	0.01441	0	0
LIN37	55957	broad.mit.edu	37	19	36244981	36244981	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr19:36244981G>A	uc002obm.2	+	8	622	c.508G>A	c.(508-510)GGG>AGG	p.G170R	uc002obl.2_5'Flank	NM_019104	NP_061977	Q96GY3	LIN37_HUMAN	lin-37 homolog	170	Pro-rich.						protein binding				0	all_lung(56;3.33e-07)|Lung NSC(56;5.02e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			CACACCCCCGGGGCCACCCGG	0.642			NA											38	86					0	0	0.01441	0	0
HKR1	284459	broad.mit.edu	37	19	37853356	37853356	+	Missense_Mutation	SNP	G	G	T	rs143859791		TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr19:37853356G>T	uc002ogb.2	+	6	928	c.659G>T	c.(658-660)AGC>ATC	p.S220I	HKR1_uc002ofx.2_5'UTR|HKR1_uc002ofy.2_5'UTR|HKR1_uc002oga.2_Missense_Mutation_p.S202I|HKR1_uc010xto.1_Missense_Mutation_p.S202I|HKR1_uc002ogc.2_Missense_Mutation_p.S201I|HKR1_uc010xtp.1_Missense_Mutation_p.S159I|HKR1_uc002ogd.2_Missense_Mutation_p.S159I	NM_181786	NP_861451	P10072	HKR1_HUMAN	GLI-Kruppel family member HKR1	220					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			ATAGGGTCCAGCCCTGAACGG	0.473			NA											48	97					1.05386e-31	1.70238e-31	0.01441	1	0
ZNF527	84503	broad.mit.edu	37	19	37879423	37879423	+	Missense_Mutation	SNP	A	A	G			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr19:37879423A>G	uc010efk.1	+	5	583	c.472A>G	c.(472-474)ACT>GCT	p.T158A	ZNF527_uc002ogf.3_Missense_Mutation_p.T126A|ZNF527_uc010xtq.1_RNA	NM_032453	NP_115829	Q8NB42	ZN527_HUMAN	zinc finger protein 527	158					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			GGAAATCTCTACTGGGAAAAG	0.398			NA											33	44					0	0	0.006999	0	0
FBXO27	126433	broad.mit.edu	37	19	39522510	39522510	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr19:39522510C>A	uc002okh.2	-	2	440	c.358G>T	c.(358-360)GGC>TGC	p.G120C		NM_178820	NP_849142	Q8NI29	FBX27_HUMAN	F-box protein 27	120	FBA.				protein catabolic process	SCF ubiquitin ligase complex	glycoprotein binding			ovary(1)	1	all_cancers(60;3.79e-07)|all_lung(34;1.26e-07)|Lung NSC(34;1.46e-07)|all_epithelial(25;4.69e-07)|Ovarian(47;0.0454)		Lung(45;0.000419)|LUSC - Lung squamous cell carcinoma(53;0.000554)			CCACCTTGGCCGCAGGGGTTG	0.701			NA											12	38					2.32078e-09	2.83509e-09	0.003163	1	0
ZNF780B	163131	broad.mit.edu	37	19	40541960	40541960	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr19:40541960C>A	uc002omu.2	-	5	871	c.806G>T	c.(805-807)AGT>ATT	p.S269I	ZNF780B_uc002omv.2_Missense_Mutation_p.S121I	NM_001005851	NP_001005851	Q9Y6R6	Z780B_HUMAN	zinc finger protein 780B	269	C2H2-type 4.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|pancreas(1)	2	all_cancers(60;9.55e-06)|all_lung(34;1.17e-07)|Lung NSC(34;1.41e-07)|Ovarian(47;0.0925)					AGCATGAATACTTTGATGCTG	0.358			NA											14	60					1.3612e-06	1.54316e-06	0.003163	1	0
ZNF780A	284323	broad.mit.edu	37	19	40581109	40581109	+	Missense_Mutation	SNP	T	T	C			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr19:40581109T>C	uc002omy.2	-	6	1465	c.1240A>G	c.(1240-1242)ATA>GTA	p.I414V	ZNF780A_uc002omw.3_Intron|ZNF780A_uc002omz.2_Missense_Mutation_p.I414V|ZNF780A_uc010xvh.1_Missense_Mutation_p.I415V	NM_001010880	NP_001010880	O75290	Z780A_HUMAN	zinc finger protein 780A isoform b	414					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_cancers(60;9.55e-06)|all_lung(34;1.17e-07)|Lung NSC(34;1.41e-07)|Ovarian(47;0.0925)					TATGGTTTTATACCAGCATGA	0.383			NA											3	201					0	0	0.004672	0	0
PSG7	5676	broad.mit.edu	37	19	43430068	43430068	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr19:43430068G>T	uc002ovl.3	-	6	1202	c.1100C>A	c.(1099-1101)ACA>AAA	p.T367K	PSG3_uc002ouf.2_Intron|PSG11_uc002ouw.2_Missense_Mutation_p.T280K|PSG7_uc002ous.1_RNA|PSG7_uc002out.1_Missense_Mutation_p.T93K|PSG10_uc002ouv.1_Intron|PSG6_uc002ovh.1_Intron|PSG6_uc002ovi.2_Intron|PSG6_uc010xwk.1_Intron|PSG11_uc002ovk.1_Missense_Mutation_p.T280K|PSG7_uc010xwl.1_Missense_Mutation_p.T245K	NM_002783	NP_002774	Q13046	PSG7_HUMAN	pregnancy specific beta-1-glycoprotein 7	367	Ig-like C2-type 3.				female pregnancy	extracellular region					0		Prostate(69;0.00682)				CCCATTAATTGTCCAAGAATA	0.458			NA											86	232					4.31119e-35	7.09416e-35	0.01441	1	0
ZNF227	7770	broad.mit.edu	37	19	44740634	44740634	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr19:44740634G>T	uc002oyu.2	+	6	2256	c.2051G>T	c.(2050-2052)GGA>GTA	p.G684V	ZNF227_uc010xwu.1_Missense_Mutation_p.G633V|ZNF227_uc002oyv.2_Missense_Mutation_p.G684V|ZNF227_uc010xwv.1_Missense_Mutation_p.G633V|ZNF227_uc010xww.1_Missense_Mutation_p.G605V|ZNF227_uc002oyw.2_Missense_Mutation_p.G656V|ZNF227_uc010ejh.2_Missense_Mutation_p.G677V|ZNF235_uc002oyx.1_Intron|ZNF235_uc010eji.2_3'UTR	NM_182490	NP_872296	Q86WZ6	ZN227_HUMAN	zinc finger protein 227	684					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Prostate(69;0.0435)				GGCCACACTGGAGAAAAACCT	0.468			NA											20	59					6.44725e-10	8.00912e-10	0.014323	1	0
MED25	81857	broad.mit.edu	37	19	50334694	50334694	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr19:50334694G>T	uc002ppw.1	+	10	1259	c.1206G>T	c.(1204-1206)TGG>TGT	p.W402C	MED25_uc010ybe.1_Missense_Mutation_p.W189C|MED25_uc002ppx.1_Missense_Mutation_p.W183C	NM_030973	NP_112235	Q71SY5	MED25_HUMAN	mediator complex subunit 25	402	Interaction with VP16.|Interaction with CREBBP.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm				ovary(1)	1		all_lung(116;3.24e-07)|Lung NSC(112;1.6e-06)|all_neural(266;0.0459)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.00822)|GBM - Glioblastoma multiforme(134;0.0122)		TTCTGGCCTGGAGCGGGGTCC	0.687	GBM(51;894 1657 37868)		NA											12	20					0.000308642	0.000328771	0.003163	1	0
SHANK1	50944	broad.mit.edu	37	19	51189549	51189549	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr19:51189549G>T	uc002psx.1	-	20	2541	c.2522C>A	c.(2521-2523)CCC>CAC	p.P841H	SHANK1_uc002psw.1_Missense_Mutation_p.P225H	NM_016148	NP_057232	Q9Y566	SHAN1_HUMAN	SH3 and multiple ankyrin repeat domains 1	841					cytoskeletal anchoring at plasma membrane	cell junction|cytoplasm|dendrite|membrane fraction|postsynaptic density|postsynaptic membrane	ionotropic glutamate receptor binding			large_intestine(2)	2		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00493)|GBM - Glioblastoma multiforme(134;0.0199)		GAGGCCACCGGGACCAGGGCT	0.592			NA											30	97					1.30897e-18	1.88646e-18	0.009535	1	0
SIGLEC6	946	broad.mit.edu	37	19	52034721	52034721	+	Silent	SNP	C	C	A			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr19:52034721C>A	uc002pwy.2	-	2	282	c.120G>T	c.(118-120)ACG>ACT	p.T40T	SIGLEC6_uc002pwz.2_Silent_p.T40T|SIGLEC6_uc002pxa.2_Silent_p.T40T|SIGLEC6_uc010ydb.1_Intron|SIGLEC6_uc010ydc.1_Silent_p.T29T|SIGLEC6_uc010eoz.1_Silent_p.T29T|SIGLEC6_uc010epb.1_Intron|SIGLEC6_uc010epa.1_Silent_p.T29T	NM_001245	NP_001236	O43699	SIGL6_HUMAN	sialic acid binding Ig-like lectin 6 isoform 1	40	Extracellular (Potential).|Ig-like V-type.				cell adhesion|cell-cell signaling	cytoplasm|extracellular region|integral to plasma membrane|membrane fraction|nucleus				ovary(1)	1		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.00115)|OV - Ovarian serous cystadenocarcinoma(262;0.0165)		CCTCCTGCACCGTCAGTGACT	0.627			NA											11	85					5.50884e-06	6.13484e-06	0.013537	1	0
ZNF320	162967	broad.mit.edu	37	19	53384141	53384141	+	Missense_Mutation	SNP	T	T	C			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr19:53384141T>C	uc002qag.2	-	4	1429	c.1238A>G	c.(1237-1239)TAC>TGC	p.Y413C	ZNF320_uc010eqh.1_5'Flank|ZNF320_uc010eqi.1_Intron|ZNF320_uc002qah.2_Missense_Mutation_p.Y359C|ZNF320_uc002qai.2_Missense_Mutation_p.Y413C	NM_207333	NP_997216	A2RRD8	ZN320_HUMAN	zinc finger protein 320	413	C2H2-type 10.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				GBM - Glioblastoma multiforme(134;0.0534)		TTCACATTCGTAAAGTTTCTC	0.393			NA											24	48					0	0	0.003271	0	0
LILRB2	10288	broad.mit.edu	37	19	54782754	54782754	+	Missense_Mutation	SNP	A	A	G	rs143661416	byFrequency	TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr19:54782754A>G	uc002qfb.2	-	6	1134	c.868T>C	c.(868-870)TAC>CAC	p.Y290H	LILRA6_uc002qew.1_Intron|LILRB2_uc010eri.2_Missense_Mutation_p.Y290H|LILRB2_uc010erj.2_RNA|LILRB2_uc002qfc.2_Missense_Mutation_p.Y290H|LILRB2_uc010yet.1_Missense_Mutation_p.Y174H|LILRB2_uc010yeu.1_RNA	NM_005874	NP_005865	Q8N423	LIRB2_HUMAN	leukocyte immunoglobulin-like receptor,	290	Extracellular (Potential).|Ig-like C2-type 3.				cell surface receptor linked signaling pathway|cell-cell signaling|cellular defense response|immune response|regulation of immune response	integral to plasma membrane|membrane fraction	receptor activity			skin(1)	1	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		TGGCCCCCGTAGGAGCGGCTC	0.667			NA											26	39					0	0	0.004878	0	0
LILRA2	11027	broad.mit.edu	37	19	55086877	55086877	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr19:55086877G>T	uc002qgg.3	+	5	899	c.810G>T	c.(808-810)CAG>CAT	p.Q270H	LILRA2_uc010ern.2_Missense_Mutation_p.Q270H|LILRA2_uc002qgf.2_Missense_Mutation_p.Q270H|LILRA2_uc010yfe.1_Missense_Mutation_p.Q270H|LILRA2_uc010yff.1_Missense_Mutation_p.Q258H|LILRA2_uc010ero.2_Missense_Mutation_p.Q258H|LILRA2_uc010yfg.1_Intron	NM_001130917	NP_001124389	Q8N149	LIRA2_HUMAN	leukocyte immunoglobulin-like receptor,	270	Ig-like C2-type 3.|Extracellular (Potential).				defense response	integral to membrane	antigen binding|receptor activity			ovary(1)	1				GBM - Glioblastoma multiforme(193;0.0963)		CTGGTTGGCAGCCCCAGGCTG	0.617			NA											56	107					2.12129e-23	3.21473e-23	0.01441	1	0
LILRA1	11024	broad.mit.edu	37	19	55106723	55106723	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr19:55106723C>A	uc002qgh.1	+	5	699	c.517C>A	c.(517-519)CGT>AGT	p.R173S	LILRA2_uc010yfg.1_Intron|LILRA1_uc010yfh.1_Missense_Mutation_p.R173S	NM_006863	NP_006854	O75019	LIRA1_HUMAN	leukocyte immunoglobulin-like receptor,	173	Ig-like C2-type 2.|Extracellular (Potential).				cell surface receptor linked signaling pathway|defense response|regulation of immune response	integral to membrane|plasma membrane	antigen binding|transmembrane receptor activity			skin(2)|ovary(1)	3				GBM - Glioblastoma multiforme(193;0.0348)		CTCACAGCCCCGTACCCATGG	0.567			NA											77	210					6.8793e-45	1.17134e-44	0.01441	1	0
NLRP7	199713	broad.mit.edu	37	19	55450745	55450745	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr19:55450745G>C	uc002qih.3	-	4	1518	c.1442C>G	c.(1441-1443)GCC>GGC	p.A481G	NLRP7_uc002qig.3_Missense_Mutation_p.A481G|NLRP7_uc002qii.3_Missense_Mutation_p.A481G|NLRP7_uc010esk.2_Missense_Mutation_p.A481G|NLRP7_uc010esl.2_Missense_Mutation_p.A509G	NM_206828	NP_996611	Q8WX94	NALP7_HUMAN	NACHT, leucine rich repeat and PYD containing 7	481	NACHT.			A -> T (in Ref. 4; AAI09126).			ATP binding			large_intestine(1)|breast(1)|central_nervous_system(1)	3				GBM - Glioblastoma multiforme(193;0.0325)		CTTCTCCAGGGCGTAGAACAG	0.592			NA											41	83					0	0	0.01441	0	0
ZNF460	10794	broad.mit.edu	37	19	57802481	57802481	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr19:57802481C>T	uc002qog.2	+	3	894	c.572C>T	c.(571-573)CCT>CTT	p.P191L	ZNF460_uc010ygv.1_Missense_Mutation_p.P150L	NM_006635	NP_006626	Q14592	ZN460_HUMAN	zinc finger protein 460	191					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0694)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		CAGATTCTCCCTCGTGTGAAG	0.448			NA											59	126					0	0	0.01441	0	0
ZNF416	55659	broad.mit.edu	37	19	58084737	58084737	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr19:58084737C>A	uc002qpf.2	-	4	706	c.535G>T	c.(535-537)GAC>TAC	p.D179Y	ZNF547_uc002qpm.3_Intron	NM_017879	NP_060349	Q9BWM5	ZN416_HUMAN	zinc finger protein 416	179					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0259)		GCTAGGAAGTCCTTCCCAACC	0.483			NA											40	97					3.61848e-18	5.17398e-18	0.007835	1	0
A1BG	1	broad.mit.edu	37	19	58858921	58858921	+	Silent	SNP	G	G	T			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr19:58858921G>T	uc002qsd.3	-	7	1340	c.1278C>A	c.(1276-1278)CCC>CCA	p.P426P	NCRNA00181_uc002qse.2_5'Flank	NM_130786	NP_570602	P04217	A1BG_HUMAN	alpha 1B-glycoprotein precursor	426	Ig-like V-type 5.					extracellular region					0		all_cancers(17;3.04e-16)|all_epithelial(17;7.77e-12)|Lung NSC(17;3.25e-05)|Colorectal(82;5.46e-05)|all_lung(17;0.000129)|all_neural(62;0.0182)|Ovarian(87;0.0443)|Breast(46;0.0889)|Renal(17;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0269)		CGTCGGGGATGGGTCCCTCGC	0.741			NA											10	16					3.07112e-06	3.43747e-06	0.010729	1	0
TPO	7173	broad.mit.edu	37	2	1426848	1426848	+	Silent	SNP	C	C	A			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr2:1426848C>A	uc002qww.2	+	3	217	c.126C>A	c.(124-126)GTC>GTA	p.V42V	TPO_uc010ewj.2_Intron|TPO_uc010yin.1_Silent_p.V42V|TPO_uc002qwu.2_Silent_p.V42V|TPO_uc002qwr.2_Silent_p.V42V|TPO_uc002qwx.2_Silent_p.V42V|TPO_uc010yio.1_Silent_p.V42V|TPO_uc010yip.1_Silent_p.V42V	NM_000547	NP_000538	P07202	PERT_HUMAN	thyroid peroxidase isoform a	42	Extracellular (Potential).				cellular nitrogen compound metabolic process|hormone biosynthetic process|hydrogen peroxide catabolic process	cell surface|cytoplasm|integral to plasma membrane	calcium ion binding|heme binding|iodide peroxidase activity			ovary(7)|pancreas(6)|skin(5)|lung(1)|kidney(1)	20	all_hematologic(175;0.0487)|Acute lymphoblastic leukemia(172;0.0627)	all_cancers(51;0.0338)		all cancers(51;0.0356)|OV - Ovarian serous cystadenocarcinoma(76;0.0748)|Epithelial(75;0.12)	Carbimazole(DB00389)|Methimazole(DB00763)|Propylthiouracil(DB00550)	TCTCTAGCGTCTTGGAGGAAA	0.582			NA											27	73					7.11191e-15	9.6801e-15	0.013726	1	0
APOB	338	broad.mit.edu	37	2	21233375	21233375	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr2:21233375G>T	uc002red.2	-	26	6493	c.6365C>A	c.(6364-6366)GCT>GAT	p.A2122D		NM_000384	NP_000375	P04114	APOB_HUMAN	apolipoprotein B precursor	2122	Heparin-binding.				cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			ovary(11)|skin(9)|central_nervous_system(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	ATAATCATTAGCTTGCTGTGG	0.368			NA											20	22					2.89027e-11	3.65217e-11	0.014323	1	0
EIF2B4	8890	broad.mit.edu	37	2	27590037	27590037	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr2:27590037C>A	uc002rkb.2	-	10	1060	c.917G>T	c.(916-918)CGG>CTG	p.R306L	EIF2B4_uc002rjz.2_Missense_Mutation_p.R326L|EIF2B4_uc002rka.2_Missense_Mutation_p.R291L|EIF2B4_uc002rkc.2_Missense_Mutation_p.R305L|EIF2B4_uc002rkd.2_Missense_Mutation_p.R100L|EIF2B4_uc002rke.2_Missense_Mutation_p.R275L|EIF2B4_uc002rkf.1_3'UTR	NM_001034116	NP_001029288	Q9UI10	EI2BD_HUMAN	eukaryotic translation initiation factor 2B,	306			R -> G.		myelination|negative regulation of translational initiation in response to stress|oligodendrocyte development|ovarian follicle development|response to glucose stimulus|response to heat|response to peptide hormone stimulus	cytosol|eukaryotic translation initiation factor 2B complex	translation initiation factor activity|translation initiation factor binding				0	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TTGCACATACCGATCAATGGC	0.433			NA											72	181					4.18771e-30	6.71557e-30	0.01441	1	0
NRXN1	9378	broad.mit.edu	37	2	50318616	50318616	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr2:50318616C>A	uc010fbp.2	-	3	1265	c.458G>T	c.(457-459)GGA>GTA	p.G153V	NRXN1_uc002rxb.3_Missense_Mutation_p.G860V|NRXN1_uc010fbq.2_Missense_Mutation_p.G1228V|NRXN1_uc002rxe.3_Missense_Mutation_p.G1188V	NM_138735	NP_620072	P58400	NRX1B_HUMAN	neurexin 1 isoform beta precursor	153	Extracellular (Potential).|Laminin G-like.				angiogenesis|neuron cell-cell adhesion|neuronal signal transduction	cell surface|endocytic vesicle|integral to membrane|presynaptic membrane	cell adhesion molecule binding|receptor binding			ovary(2)	2		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.192)	Lung(47;0.0813)|LUSC - Lung squamous cell carcinoma(58;0.116)			AAACTTAACTCCAATTTTTCC	0.363			NA											28	74					4.22769e-11	5.3269e-11	0.00632	1	0
PPP3R1	5534	broad.mit.edu	37	2	68413773	68413773	+	Missense_Mutation	SNP	T	T	C			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr2:68413773T>C	uc002sei.1	-	5	684	c.292A>G	c.(292-294)ATC>GTC	p.I98V		NM_000945	NP_000936	P63098	CANB1_HUMAN	protein phosphatase 3, regulatory subunit B,	98	EF-hand 3.				activation of pro-apoptotic gene products|induction of apoptosis by intracellular signals	calcineurin complex|cytosol	calcium ion binding|calcium-dependent protein serine/threonine phosphatase activity|calmodulin binding				0					Pimecrolimus(DB00337)	ATGTCATAGATACGGAAAGCA	0.348			NA											7	11					0	0	0.00308	0	0
PLEK	5341	broad.mit.edu	37	2	68607985	68607985	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr2:68607985C>A	uc002sen.3	+	3	491	c.329C>A	c.(328-330)GCC>GAC	p.A110D	PLEK_uc010fde.2_Missense_Mutation_p.A110D	NM_002664	NP_002655	P08567	PLEK_HUMAN	pleckstrin	110					actin cytoskeleton reorganization|cortical actin cytoskeleton organization|hemopoietic progenitor cell differentiation|inhibition of phospholipase C activity involved in G-protein coupled receptor signaling pathway|integrin-mediated signaling pathway|negative regulation of calcium-mediated signaling|negative regulation of inositol phosphate biosynthetic process|phosphatidylinositol metabolic process|platelet aggregation|positive regulation of actin filament bundle assembly|positive regulation of actin filament depolymerization|positive regulation of inositol-polyphosphate 5-phosphatase activity|positive regulation of integrin activation|positive regulation of platelet activation|protein kinase C signaling cascade|protein secretion by platelet|regulation of cell diameter|ruffle organization|thrombin receptor signaling pathway|vesicle docking involved in exocytosis	cytosol|extracellular region|membrane fraction|ruffle membrane|soluble fraction	phosphatidylinositol-3,4-bisphosphate binding|protein homodimerization activity|protein kinase C binding			ovary(1)	1		Ovarian(717;0.0129)		STAD - Stomach adenocarcinoma(1183;0.00159)|READ - Rectum adenocarcinoma(193;0.0419)		CAGAAATTTGCCAGGAAATCT	0.473			NA											90	202					4.98208e-43	8.41799e-43	0.01441	1	0
LRRTM4	80059	broad.mit.edu	37	2	77745546	77745546	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr2:77745546C>A	uc002snr.2	-	3	1864	c.1449G>T	c.(1447-1449)GAG>GAT	p.E483D	LRRTM4_uc002snq.2_Missense_Mutation_p.E483D|LRRTM4_uc002sns.2_Missense_Mutation_p.E483D|LRRTM4_uc002snt.2_Missense_Mutation_p.E484D	NM_001134745	NP_001128217	Q86VH4	LRRT4_HUMAN	leucine rich repeat transmembrane neuronal 4	483	Cytoplasmic (Potential).					integral to membrane				pancreas(3)|ovary(1)	4				Colorectal(11;0.059)		CCACATAATACTCCTGTAAAG	0.473			NA											3	24					0.004672	0.00489395	0.004672	1	0
SLC9A4	389015	broad.mit.edu	37	2	103095664	103095664	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr2:103095664C>T	uc002tbz.3	+	2	1080	c.623C>T	c.(622-624)CCA>CTA	p.P208L		NM_001011552	NP_001011552	Q6AI14	SL9A4_HUMAN	solute carrier family 9 (sodium/hydrogen	208	Helical; Name=F/M5A; (Potential).				regulation of pH	apical plasma membrane|basolateral plasma membrane|integral to membrane	sodium:hydrogen antiporter activity			skin(2)|central_nervous_system(1)	3						GCCGTGGACCCAGTGGCCGTG	0.597			NA											10	19					0	0	0.00245	0	0
SULT1C3	442038	broad.mit.edu	37	2	108881745	108881745	+	Missense_Mutation	SNP	T	T	C			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr2:108881745T>C	uc010ywo.1	+	7	853	c.853T>C	c.(853-855)TTT>CTT	p.F285L		NM_001008743	NP_001008743	Q6IMI6	ST1C3_HUMAN	sulfotransferase family, cytosolic, 1C, member	285						cytoplasm	alcohol sulfotransferase activity			skin(1)	1						AAATGAAGAATTTGACAAGGA	0.473			NA											22	56					0	0	0.004656	0	0
MAP3K2	10746	broad.mit.edu	37	2	128088066	128088066	+	Missense_Mutation	SNP	T	T	C			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr2:128088066T>C	uc002toj.1	-	5	345	c.280A>G	c.(280-282)ACT>GCT	p.T94A	MAP3K2_uc010flz.1_Missense_Mutation_p.T94A	NM_006609	NP_006600	Q9Y2U5	M3K2_HUMAN	mitogen-activated protein kinase kinase kinase	94	OPR.				activation of JUN kinase activity|cellular response to mechanical stimulus	nucleus	ATP binding|MAP kinase kinase kinase activity|metal ion binding|protein kinase binding			lung(3)|ovary(2)|large_intestine(1)|central_nervous_system(1)	7	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0706)		TCTTGAGTAGTTAATGGAATT	0.378			NA											2	10					0	0	0.004672	0	0
LRP1B	53353	broad.mit.edu	37	2	141812830	141812830	+	Splice_Site	SNP	T	T	A			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr2:141812830T>A	uc002tvj.1	-	10	2381	c.1409_splice	c.e10-1	p.V470_splice	LRP1B_uc010fnl.1_Intron	NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B						protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		GGCTTCTGACTACAACAAATA	0.398	Colon(99;50 2074 2507 20106)		NA								TSP Lung(27;0.18)			6	21					0	0	0.001168	0	0
NEB	4703	broad.mit.edu	37	2	152522052	152522052	+	Missense_Mutation	SNP	T	T	A			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr2:152522052T>A	uc010fnx.2	-	42	5224	c.5033A>T	c.(5032-5034)AAT>ATT	p.N1678I		NM_004543	NP_004534	P20929	NEBU_HUMAN	nebulin isoform 3	1678	Nebulin 43.				muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			ovary(8)|large_intestine(5)|breast(3)|central_nervous_system(2)|skin(1)|pancreas(1)	20				BRCA - Breast invasive adenocarcinoma(221;0.219)		TTTGTACAGATTCTTTACAAT	0.398			NA											9	15					0	0	0.008291	0	0
SCN3A	6328	broad.mit.edu	37	2	165997321	165997321	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr2:165997321C>T	uc002ucx.2	-	13	2351	c.1859G>A	c.(1858-1860)CGA>CAA	p.R620Q	SCN3A_uc002ucy.2_Missense_Mutation_p.R620Q|SCN3A_uc002ucz.2_Missense_Mutation_p.R620Q|SCN3A_uc002uda.1_Missense_Mutation_p.R489Q|SCN3A_uc002udb.1_Missense_Mutation_p.R489Q	NM_006922	NP_008853	Q9NY46	SCN3A_HUMAN	sodium channel, voltage-gated, type III, alpha	620						voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(4)|breast(3)|skin(2)|central_nervous_system(1)	10					Lamotrigine(DB00555)	ACTGTTGCGTCGCTCTCCATG	0.498			NA											18	50					0	0	0.007413	0	0
OLA1	29789	broad.mit.edu	37	2	175111467	175111467	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr2:175111467C>A	uc002uih.2	-	2	263	c.77G>T	c.(76-78)GGT>GTT	p.G26V	OLA1_uc002uii.2_Intron|OLA1_uc010fqq.2_Missense_Mutation_p.G26V|OLA1_uc002uij.2_Intron|OLA1_uc002uik.2_5'UTR|OLA1_uc010fqr.2_Missense_Mutation_p.G26V	NM_013341	NP_037473	Q9NTK5	OLA1_HUMAN	Obg-like ATPase 1 isoform 1	26					ATP catabolic process	cytoplasm	ATP binding|GTP binding|hydrolase activity|protein binding			ovary(1)|breast(1)	2						TCCAACAATACCAATTTTCAG	0.398			NA											31	100					1.45844e-13	1.95492e-13	0.013726	1	0
GPR155	151556	broad.mit.edu	37	2	175300882	175300882	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr2:175300882C>T	uc002uit.2	-	17	2966	c.2575G>A	c.(2575-2577)GAG>AAG	p.E859K	GPR155_uc002uiu.2_Missense_Mutation_p.E859K|GPR155_uc002uiv.2_Missense_Mutation_p.E859K|GPR155_uc010fqs.2_Missense_Mutation_p.E831K	NM_001033045	NP_001028217	Q7Z3F1	GP155_HUMAN	G protein-coupled receptor 155 isoform 9	859					intracellular signal transduction|transmembrane transport	integral to membrane				ovary(1)	1						GATGAATGCTCAATTTCTTTA	0.393			NA											4	164					0	0	0.009096	0	0
TTN	7273	broad.mit.edu	37	2	179415733	179415733	+	Missense_Mutation	SNP	A	A	T			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr2:179415733A>T	uc010zfg.1	-	285	84045	c.83821T>A	c.(83821-83823)TCA>ACA	p.S27941T	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.S21636T|TTN_uc010zfi.1_Missense_Mutation_p.S21569T|TTN_uc010zfj.1_Missense_Mutation_p.S21444T	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	28868							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GAAGACTGTGAGGGCGGGCTT	0.388			NA											8	20					0	0	0.004482	0	0
TTN	7273	broad.mit.edu	37	2	179422644	179422644	+	Missense_Mutation	SNP	A	A	T			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr2:179422644A>T	uc010zfg.1	-	277	79957	c.79733T>A	c.(79732-79734)GTT>GAT	p.V26578D	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.V20273D|TTN_uc010zfi.1_Missense_Mutation_p.V20206D|TTN_uc010zfj.1_Missense_Mutation_p.V20081D	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	27505							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ATCACTAATAACAACAGGGCC	0.433			NA											45	260					0	0	0.01441	0	0
TTN	7273	broad.mit.edu	37	2	179474458	179474458	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr2:179474458C>A	uc010zfg.1	-	221	44212	c.43988G>T	c.(43987-43989)AGT>ATT	p.S14663I	uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.S8358I|TTN_uc010zfi.1_Missense_Mutation_p.S8291I|TTN_uc010zfj.1_Missense_Mutation_p.S8166I	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	15590							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AGAAGGTTCACTAATACCCGC	0.448			NA											52	138					2.43468e-25	3.7281e-25	0.01441	1	0
TTN	7273	broad.mit.edu	37	2	179610734	179610734	+	Silent	SNP	G	G	T			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr2:179610734G>T	uc002unb.2	-	46	16617	c.16393C>A	c.(16393-16395)CGG>AGG	p.R5465R	TTN_uc010zfg.1_Intron|TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Intron	NM_133379	NP_596870	Q8WZ42	TITIN_HUMAN	titin isoform novex-3	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AGGAATCCCCGACAGATAGCC	0.408			NA											36	92					1.04594e-18	1.5173e-18	0.00623	1	0
MARS2	92935	broad.mit.edu	37	2	198571112	198571112	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr2:198571112G>A	uc002uuq.2	+	1	1026	c.983G>A	c.(982-984)GGC>GAC	p.G328D	uc002uup.2_Intron	NM_138395	NP_612404	Q96GW9	SYMM_HUMAN	methionine-tRNA synthetase 2 precursor	328					methionyl-tRNA aminoacylation	mitochondrial matrix	ATP binding|methionine-tRNA ligase activity			ovary(1)|central_nervous_system(1)|skin(1)	3					L-Methionine(DB00134)	TTAGGGGCCGGCATGAGCCCG	0.542			NA											6	351					0	0	0.001984	0	0
ADAM23	8745	broad.mit.edu	37	2	207437900	207437900	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr2:207437900G>T	uc002vbq.2	+	18	1941	c.1718G>T	c.(1717-1719)TGT>TTT	p.C573F	ADAM23_uc010ziv.1_RNA	NM_003812	NP_003803	O75077	ADA23_HUMAN	ADAM metallopeptidase domain 23 preproprotein	573	Disintegrin.|Extracellular (Potential).				cell adhesion|central nervous system development|proteolysis	extracellular region|integral to plasma membrane	integrin binding|metalloendopeptidase activity|zinc ion binding			skin(2)|ovary(1)	3				LUSC - Lung squamous cell carcinoma(261;0.0961)|Lung(261;0.182)|Epithelial(149;0.205)		ACTGAATATTGTACTGGAGAC	0.308	Melanoma(194;1127 2130 19620 24042 27855)		NA											63	161					1.55545e-33	2.53119e-33	0.01441	1	0
ZNF142	7701	broad.mit.edu	37	2	219503486	219503486	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr2:219503486C>A	uc002vin.2	-	10	5076	c.4640G>T	c.(4639-4641)CGG>CTG	p.R1547L	ZNF142_uc002vil.2_Missense_Mutation_p.R1508L|ZNF142_uc010fvt.2_Missense_Mutation_p.R1384L|ZNF142_uc002vim.2_Missense_Mutation_p.R1384L	NM_001105537	NP_001099007	P52746	ZN142_HUMAN	zinc finger protein 142	1547	C2H2-type 28.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|ovary(1)|skin(1)	4		Renal(207;0.0474)		Epithelial(149;5.21e-07)|all cancers(144;0.000106)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)		TGCATCAGCCCGGTTGGTGCA	0.572	Colon(170;867 1942 8995 15834 18053)		NA											12	32					1.02788e-11	1.33323e-11	0.00499	1	0
STK36	27148	broad.mit.edu	37	2	219562210	219562210	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr2:219562210C>T	uc002viu.2	+	24	3052	c.2786C>T	c.(2785-2787)GCC>GTC	p.A929V	STK36_uc002viv.2_Missense_Mutation_p.A908V|STK36_uc002viw.2_Missense_Mutation_p.A107V|STK36_uc002vix.2_5'UTR	NM_015690	NP_056505	Q9NRP7	STK36_HUMAN	serine/threonine kinase 36	929					cilium assembly|positive regulation of hh target transcription factor activity|positive regulation of smoothened signaling pathway|post-embryonic development	aggresome|cytoplasm|focal adhesion|intermediate filament cytoskeleton|nucleus	ATP binding|protein serine/threonine kinase activity|transcription factor binding			ovary(4)|stomach(2)|lung(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)	11		Renal(207;0.0915)		Epithelial(149;9.65e-07)|all cancers(144;0.000174)|LUSC - Lung squamous cell carcinoma(224;0.00813)|Lung(261;0.00984)		CTGAGCCTGGCCATGGCCACC	0.587			NA											17	61					0	0	0.006122	0	0
STK36	27148	broad.mit.edu	37	2	219563440	219563440	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr2:219563440C>T	uc002viu.2	+	26	3439	c.3173C>T	c.(3172-3174)TCC>TTC	p.S1058F	STK36_uc002viv.2_Missense_Mutation_p.S1037F|STK36_uc002viw.2_Missense_Mutation_p.S236F|STK36_uc002vix.2_Missense_Mutation_p.S103F	NM_015690	NP_056505	Q9NRP7	STK36_HUMAN	serine/threonine kinase 36	1058					cilium assembly|positive regulation of hh target transcription factor activity|positive regulation of smoothened signaling pathway|post-embryonic development	aggresome|cytoplasm|focal adhesion|intermediate filament cytoskeleton|nucleus	ATP binding|protein serine/threonine kinase activity|transcription factor binding			ovary(4)|stomach(2)|lung(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)	11		Renal(207;0.0915)		Epithelial(149;9.65e-07)|all cancers(144;0.000174)|LUSC - Lung squamous cell carcinoma(224;0.00813)|Lung(261;0.00984)		GTGTCTGCCTCCCCTAGAACC	0.572			NA											116	284					0	0	0.01441	0	0
ACCN4	55515	broad.mit.edu	37	2	220379514	220379514	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr2:220379514C>A	uc002vma.2	+	1	463	c.449C>A	c.(448-450)GCA>GAA	p.A150E	ACCN4_uc010fwi.1_Missense_Mutation_p.A150E|ACCN4_uc010fwj.1_Missense_Mutation_p.A150E|ACCN4_uc002vly.1_Missense_Mutation_p.A150E|ACCN4_uc002vlz.2_Missense_Mutation_p.A150E|ACCN4_uc002vmb.2_5'Flank	NM_182847	NP_878267	Q96FT7	ACCN4_HUMAN	amiloride-sensitive cation channel 4 isoform 2	150	Cytoplasmic (Potential).					integral to plasma membrane	sodium channel activity|sodium ion transmembrane transporter activity			ovary(2)	2		Renal(207;0.0183)		Epithelial(149;5.47e-10)|all cancers(144;9e-08)|LUSC - Lung squamous cell carcinoma(224;0.00813)|Lung(261;0.0086)|READ - Rectum adenocarcinoma(5;0.156)		GAGAAGGAGGCAGGGGATGAG	0.632			NA											50	154					9.55421e-19	1.39056e-18	0.01441	1	0
CUL3	8452	broad.mit.edu	37	2	225376300	225376300	+	Splice_Site	SNP	C	C	T			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr2:225376300C>T	uc002vny.2	-	6	1039	c.655_splice	c.e6-1	p.M219_splice	CUL3_uc010zls.1_Splice_Site_p.M153_splice|CUL3_uc010fwy.1_Splice_Site_p.M225_splice	NM_003590	NP_003581	Q13618	CUL3_HUMAN	cullin 3						cell cycle arrest|cell migration|cyclin catabolic process|cytokinesis|G1/S transition of mitotic cell cycle|induction of apoptosis by intracellular signals|mitotic anaphase|negative regulation of Rho protein signal transduction|positive regulation of cell proliferation|protein ubiquitination|stress fiber assembly	Cul3-RING ubiquitin ligase complex|Golgi apparatus|nucleus|polar microtubule	ubiquitin protein ligase binding			upper_aerodigestive_tract(1)|ovary(1)|liver(1)|kidney(1)	4		all_lung(227;0.00877)|Lung NSC(271;0.011)|Renal(207;0.0112)|all_hematologic(139;0.138)		Epithelial(121;1.58e-11)|all cancers(144;1.43e-08)|Lung(261;0.00863)|LUSC - Lung squamous cell carcinoma(224;0.00902)		GGCTTTCCATCTGCCatttaa	0.289			NA											17	31					0	0	0.004007	0	0
ARMC9	80210	broad.mit.edu	37	2	232141472	232141472	+	Silent	SNP	C	C	G			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr2:232141472C>G	uc002vrq.3	+	15	1570	c.1458C>G	c.(1456-1458)CTC>CTG	p.L486L	ARMC9_uc002vrp.3_Silent_p.L486L|ARMC9_uc002vrr.1_RNA	NM_025139	NP_079415	Q7Z3E5	ARMC9_HUMAN	armadillo repeat containing 9	486							binding			ovary(1)	1		Renal(207;0.0112)|all_lung(227;0.0744)|all_hematologic(139;0.0749)|Acute lymphoblastic leukemia(138;0.167)|Medulloblastoma(418;0.184)|Lung NSC(271;0.205)		Epithelial(121;1.43e-10)|LUSC - Lung squamous cell carcinoma(224;0.017)|Lung(119;0.0189)		TCATGAACCTCTGCCTCCGCA	0.537			NA											12	144					0	0	0.003163	0	0
DIS3L2	129563	broad.mit.edu	37	2	233075098	233075098	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr2:233075098G>T	uc010fxz.2	+	10	1463	c.1187G>T	c.(1186-1188)TGC>TTC	p.C396F	DIS3L2_uc002vsm.3_RNA|DIS3L2_uc002vso.2_RNA	NM_152383	NP_689596	Q8IYB7	DI3L2_HUMAN	DIS3 mitotic control homolog (S.	396							exonuclease activity|ribonuclease activity|RNA binding			ovary(1)|breast(1)|central_nervous_system(1)	3		all_hematologic(139;0.00809)|Renal(207;0.0113)|Acute lymphoblastic leukemia(138;0.0195)|all_lung(227;0.0465)|Lung NSC(271;0.136)		Epithelial(121;1.6e-13)|BRCA - Breast invasive adenocarcinoma(100;0.00104)|LUSC - Lung squamous cell carcinoma(224;0.0109)|Lung(119;0.0149)		GCCCTCTCCTGCAAGCCACTC	0.507			NA											19	57					6.32553e-13	8.35197e-13	0.004656	1	0
NOP56	10528	broad.mit.edu	37	20	2638609	2638609	+	Missense_Mutation	SNP	A	A	C			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr20:2638609A>C	uc002wgh.2	+	12	1507	c.1454A>C	c.(1453-1455)CAA>CCA	p.Q485P	NOP56_uc010zpy.1_RNA|NOP56_uc002wgi.2_Missense_Mutation_p.Q319P|NOP56_uc002wgm.1_3'UTR	NM_006392	NP_006383	O00567	NOP56_HUMAN	nucleolar protein 5A	485	Lys-rich.				rRNA processing	box C/D snoRNP complex|pre-snoRNP complex	protein binding|snoRNA binding			ovary(1)|pancreas(1)	2						AAGAAAAAGCAAAAGCCCCAG	0.428			NA											177	278					0	0	0.01441	0	0
CRNKL1	51340	broad.mit.edu	37	20	20031146	20031146	+	Nonsense_Mutation	SNP	C	C	A			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr20:20031146C>A	uc002wrs.2	-	3	687	c.655G>T	c.(655-657)GAA>TAA	p.E219*	C20orf26_uc010gcw.1_5'Flank|C20orf26_uc010zse.1_5'Flank|C20orf26_uc002wru.2_5'Flank|CRNKL1_uc002wrt.1_Nonsense_Mutation_p.E207*	NM_016652	NP_057736	Q9BZJ0	CRNL1_HUMAN	crooked neck-like 1 protein	219					spliceosome assembly	catalytic step 2 spliceosome|cytoplasm|nuclear speck	RNA binding			ovary(2)|large_intestine(1)	3						TCATTTAATTCTTCTTCATCT	0.388			NA											28	72					9.39395e-14	1.26303e-13	0.00632	1	0
KIAA1755	85449	broad.mit.edu	37	20	36868046	36868046	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr20:36868046G>A	uc002xhy.1	-	4	1903	c.1631C>T	c.(1630-1632)GCT>GTT	p.A544V	KIAA1755_uc002xhz.1_Missense_Mutation_p.A544V	NM_001029864	NP_001025035	Q5JYT7	K1755_HUMAN	hypothetical protein LOC85449	544										ovary(4)|pancreas(1)	5		Myeloproliferative disorder(115;0.00874)				GCCTGCAGAAGCTTCTGGCAA	0.602			NA											37	116					0	0	0.011902	0	0
HNF4A	3172	broad.mit.edu	37	20	43048493	43048493	+	Missense_Mutation	SNP	A	A	C			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr20:43048493A>C	uc002xma.2	+	7	958	c.869A>C	c.(868-870)AAA>ACA	p.K290T	HNF4A_uc002xlt.2_Missense_Mutation_p.K268T|HNF4A_uc002xlu.2_Missense_Mutation_p.K268T|HNF4A_uc002xlv.2_Missense_Mutation_p.K268T|HNF4A_uc002xly.2_Missense_Mutation_p.K290T|HNF4A_uc002xlz.2_Missense_Mutation_p.K290T|HNF4A_uc010ggq.2_Missense_Mutation_p.K283T	NM_000457	NP_000448	P41235	HNF4A_HUMAN	hepatocyte nuclear factor 4 alpha isoform b	290					blood coagulation|endocrine pancreas development|glucose homeostasis|negative regulation of cell growth|negative regulation of cell proliferation|ornithine metabolic process|phospholipid homeostasis|positive regulation of cholesterol homeostasis|regulation of growth hormone receptor signaling pathway|regulation of insulin secretion|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to glucose stimulus|triglyceride homeostasis|xenobiotic metabolic process	cytoplasm	activating transcription factor binding|protein homodimerization activity|receptor binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|steroid hormone receptor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(1)|lung(1)|skin(1)	3		Myeloproliferative disorder(115;0.0122)	COAD - Colon adenocarcinoma(18;0.00189)			GCCTACCTCAAAGCCATCATC	0.547	Colon(79;2 1269 8820 14841 52347)		NA											45	147					0	0	0.01441	0	0
BIRC7	79444	broad.mit.edu	37	20	61870735	61870735	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr20:61870735G>T	uc002yej.2	+	6	848	c.675G>T	c.(673-675)CAG>CAT	p.Q225H	BIRC7_uc010gkc.1_3'UTR|BIRC7_uc002yei.2_Intron	NM_139317	NP_647478	Q96CA5	BIRC7_HUMAN	livin inhibitor of apoptosis isoform alpha	225					activation of JUN kinase activity|anti-apoptosis|DNA fragmentation involved in apoptotic nuclear change	cytoplasm|nucleus	enzyme binding|zinc ion binding			ovary(1)|lung(1)|kidney(1)	3	all_cancers(38;2.72e-09)					CCGAGGCCCAGAGGGCGTGGT	0.692			NA											63	56					9.65139e-37	1.60614e-36	0.01441	1	0
POTED	317754	broad.mit.edu	37	21	14983042	14983042	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr21:14983042G>T	uc002yjb.1	+	1	545	c.493G>T	c.(493-495)GAC>TAC	p.D165Y		NM_174981	NP_778146	Q86YR6	POTED_HUMAN	pote protein	165						plasma membrane				ovary(3)|skin(3)	6						CAGGGACACTGACATGAACAA	0.577			NA											18	106					2.48779e-11	3.15264e-11	0.005443	1	0
ADAMTS5	11096	broad.mit.edu	37	21	28296491	28296491	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr21:28296491C>G	uc002ymg.2	-	8	3403	c.2674G>C	c.(2674-2676)GAC>CAC	p.D892H		NM_007038	NP_008969	Q9UNA0	ATS5_HUMAN	ADAM metallopeptidase with thrombospondin type 1	892	TSP type-1 2.				proteolysis	proteinaceous extracellular matrix	integrin binding|metalloendopeptidase activity|zinc ion binding			upper_aerodigestive_tract(2)|ovary(1)|pancreas(1)	4						CAACCTGTGTCACAGGTCCTA	0.542	Esophageal Squamous(53;683 1080 10100 14424 45938)		NA											26	73					0	0	0.005443	0	0
KRTAP13-3	337960	broad.mit.edu	37	21	31798219	31798219	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr21:31798219G>T	uc002yob.1	-	1	12	c.12C>A	c.(10-12)AAC>AAA	p.N4K		NM_181622	NP_853653	Q3SY46	KR133_HUMAN	keratin associated protein 13-3	4						intermediate filament				ovary(1)|lung(1)	2						TAGAGCAACAGTTGTAGGACA	0.512			NA											19	91					6.33239e-15	8.64577e-15	0.010504	1	0
KRTAP11-1	337880	broad.mit.edu	37	21	32253670	32253670	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr21:32253670C>G	uc002yov.2	-	1	205	c.174G>C	c.(172-174)GAG>GAC	p.E58D		NM_175858	NP_787054	Q8IUC1	KR111_HUMAN	keratin associated protein 11-1	58						keratin filament	structural molecule activity			pancreas(1)	1						CACAGCAGGTCTCTTGACAGT	0.557			NA											28	67					0	0	0.004656	0	0
SON	6651	broad.mit.edu	37	21	34922564	34922564	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr21:34922564C>T	uc002yse.1	+	3	1076	c.1027C>T	c.(1027-1029)CCT>TCT	p.P343S	SON_uc002ysb.1_Missense_Mutation_p.P343S|SON_uc002ysc.2_Missense_Mutation_p.P343S|SON_uc002ysd.2_5'UTR|SON_uc002ysf.1_Intron|SON_uc002ysg.2_5'Flank	NM_138927	NP_620305	P18583	SON_HUMAN	SON DNA-binding protein isoform F	343					anti-apoptosis|cytokinesis|mRNA processing|regulation of cell cycle|regulation of RNA splicing|RNA splicing|spindle pole body separation	nuclear speck	DNA binding|double-stranded RNA binding			ovary(4)|skin(2)	6						GCCAGAGCAGCCTGTAGACGT	0.517			NA									OREG0003564	type=REGULATORY REGION|Gene=AK074269|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	49	101					0	0	0.01441	0	0
SON	6651	broad.mit.edu	37	21	34923302	34923302	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr21:34923302G>T	uc002yse.1	+	3	1814	c.1765G>T	c.(1765-1767)GTG>TTG	p.V589L	SON_uc002ysb.1_Missense_Mutation_p.V589L|SON_uc002ysc.2_Missense_Mutation_p.V589L|SON_uc002ysd.2_5'UTR|SON_uc002ysf.1_Intron|SON_uc002ysg.2_5'Flank	NM_138927	NP_620305	P18583	SON_HUMAN	SON DNA-binding protein isoform F	589					anti-apoptosis|cytokinesis|mRNA processing|regulation of cell cycle|regulation of RNA splicing|RNA splicing|spindle pole body separation	nuclear speck	DNA binding|double-stranded RNA binding			ovary(4)|skin(2)	6						GGGGCAGCCTGTGGCAACTGG	0.662			NA											21	64					7.41877e-09	8.98813e-09	0.012319	1	0
DOPEY2	9980	broad.mit.edu	37	21	37618548	37618548	+	Missense_Mutation	SNP	A	A	T			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr21:37618548A>T	uc002yvg.2	+	19	4349	c.4270A>T	c.(4270-4272)ATT>TTT	p.I1424F	DOPEY2_uc011aeb.1_Missense_Mutation_p.I1373F|DOPEY2_uc002yvh.2_Missense_Mutation_p.I275F	NM_005128	NP_005119	Q9Y3R5	DOP2_HUMAN	pad-1-like	1424					endoplasmic reticulum organization|Golgi to endosome transport|multicellular organismal development|protein transport	Golgi membrane				ovary(1)|central_nervous_system(1)	2						GGAGAGTCTCATTAACTTGGG	0.612			NA											10	70					0	0	0.001855	0	0
HLCS	3141	broad.mit.edu	37	21	38137445	38137445	+	Silent	SNP	A	A	G			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr21:38137445A>G	uc010gnb.2	-	8	2749	c.1548T>C	c.(1546-1548)CCT>CCC	p.P516P	HLCS_uc002yvs.2_Silent_p.P516P	NM_000411	NP_000402	P50747	BPL1_HUMAN	holocarboxylase synthetase	516					cell proliferation|histone biotinylation|response to biotin	chromatin|cytosol|mitochondrion|nuclear lamina|nuclear matrix	ATP binding|biotin binding|biotin-[acetyl-CoA-carboxylase] ligase activity|biotin-[methylcrotonoyl-CoA-carboxylase] ligase activity|biotin-[methylmalonyl-CoA-carboxytransferase] ligase activity|biotin-[propionyl-CoA-carboxylase (ATP-hydrolyzing)] ligase activity|enzyme binding			ovary(2)|breast(1)|kidney(1)|liver(1)	5		Myeloproliferative disorder(46;0.0422)			Biotin(DB00121)	CACATCCCACAGGGCTCAGCC	0.577			NA											3	73					0	0	0.009096	0	0
ETS2	2114	broad.mit.edu	37	21	40191577	40191577	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr21:40191577C>T	uc002yxg.2	+	8	1158	c.962C>T	c.(961-963)TCT>TTT	p.S321F	ETS2_uc002yxf.2_Missense_Mutation_p.S461F	NM_005239	NP_005230	P15036	ETS2_HUMAN	v-ets erythroblastosis virus E26 oncogene	321					positive regulation of transcription, DNA-dependent|skeletal system development	nucleus	protein binding|sequence-specific DNA binding transcription factor activity			ovary(1)|lung(1)|breast(1)|pancreas(1)	4		Prostate(19;6.33e-08)|all_epithelial(19;0.123)				TGCAGCCAGTCTCTCTGCCTC	0.532			NA											8	29					0	0	0.008291	0	0
COL6A2	1292	broad.mit.edu	37	21	47542430	47542430	+	Silent	SNP	C	C	G			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr21:47542430C>G	uc002zia.1	+	20	1675	c.1593C>G	c.(1591-1593)GGC>GGG	p.G531G	COL6A2_uc002zhy.1_Silent_p.G531G|COL6A2_uc002zhz.1_Silent_p.G531G|COL6A2_uc002zib.1_Intron	NM_001849	NP_001840	P12110	CO6A2_HUMAN	alpha 2 type VI collagen isoform 2C2 precursor	531	Triple-helical region.		G -> R (in UCMD).		axon guidance|cell-cell adhesion|extracellular matrix organization|protein heterotrimerization	collagen|extracellular space|protein complex	extracellular matrix structural constituent|protein binding, bridging			central_nervous_system(7)|ovary(1)	8	Breast(49;0.245)			Colorectal(79;0.0303)|READ - Rectum adenocarcinoma(84;0.0649)		GCGAGCCCGGCCCACGCGGCC	0.637			NA											8	101					0	0	0.006214	0	0
CCT8L2	150160	broad.mit.edu	37	22	17072057	17072057	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr22:17072057C>G	uc002zlp.1	-	1	1644	c.1384G>C	c.(1384-1386)GAC>CAC	p.D462H		NM_014406	NP_055221	Q96SF2	TCPQM_HUMAN	T-complex protein 1	462					cellular protein metabolic process	cytoplasm	anion channel activity|ATP binding|calcium-activated potassium channel activity			ovary(1)	1	all_hematologic(4;0.00567)|Acute lymphoblastic leukemia(84;0.0977)	all_epithelial(15;0.0157)|Lung NSC(13;0.147)|all_lung(157;0.175)				GCCATCACGTCTGAGACAGCT	0.527			NA											71	196					0	0	0.01441	0	0
CCT8L2	150160	broad.mit.edu	37	22	17072155	17072155	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr22:17072155C>T	uc002zlp.1	-	1	1546	c.1286G>A	c.(1285-1287)AGA>AAA	p.R429K		NM_014406	NP_055221	Q96SF2	TCPQM_HUMAN	T-complex protein 1	429					cellular protein metabolic process	cytoplasm	anion channel activity|ATP binding|calcium-activated potassium channel activity			ovary(1)	1	all_hematologic(4;0.00567)|Acute lymphoblastic leukemia(84;0.0977)	all_epithelial(15;0.0157)|Lung NSC(13;0.147)|all_lung(157;0.175)				CCCTTCCAATCTGCTTCCTTT	0.488			NA											40	79					0	0	0.011902	0	0
CCT8L2	150160	broad.mit.edu	37	22	17072228	17072228	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr22:17072228C>G	uc002zlp.1	-	1	1473	c.1213G>C	c.(1213-1215)GAT>CAT	p.D405H		NM_014406	NP_055221	Q96SF2	TCPQM_HUMAN	T-complex protein 1	405					cellular protein metabolic process	cytoplasm	anion channel activity|ATP binding|calcium-activated potassium channel activity			ovary(1)	1	all_hematologic(4;0.00567)|Acute lymphoblastic leukemia(84;0.0977)	all_epithelial(15;0.0157)|Lung NSC(13;0.147)|all_lung(157;0.175)				AGTCTGGGATCTTGACATAGC	0.557			NA											34	60					0	0	0.003755	0	0
CCT8L2	150160	broad.mit.edu	37	22	17072351	17072351	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr22:17072351C>G	uc002zlp.1	-	1	1350	c.1090G>C	c.(1090-1092)GAA>CAA	p.E364Q		NM_014406	NP_055221	Q96SF2	TCPQM_HUMAN	T-complex protein 1	364					cellular protein metabolic process	cytoplasm	anion channel activity|ATP binding|calcium-activated potassium channel activity			ovary(1)	1	all_hematologic(4;0.00567)|Acute lymphoblastic leukemia(84;0.0977)	all_epithelial(15;0.0157)|Lung NSC(13;0.147)|all_lung(157;0.175)				CATTCCCATTCAAATACCACA	0.612			NA											38	116					0	0	0.006999	0	0
CCT8L2	150160	broad.mit.edu	37	22	17072376	17072376	+	Silent	SNP	C	C	G			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr22:17072376C>G	uc002zlp.1	-	1	1325	c.1065G>C	c.(1063-1065)CTG>CTC	p.L355L		NM_014406	NP_055221	Q96SF2	TCPQM_HUMAN	T-complex protein 1	355					cellular protein metabolic process	cytoplasm	anion channel activity|ATP binding|calcium-activated potassium channel activity			ovary(1)	1	all_hematologic(4;0.00567)|Acute lymphoblastic leukemia(84;0.0977)	all_epithelial(15;0.0157)|Lung NSC(13;0.147)|all_lung(157;0.175)				AACCATCTCCCAGCTCCTGCC	0.587			NA											40	120					0	0	0.01441	0	0
CCT8L2	150160	broad.mit.edu	37	22	17073279	17073279	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr22:17073279G>T	uc002zlp.1	-	1	422	c.162C>A	c.(160-162)CAC>CAA	p.H54Q		NM_014406	NP_055221	Q96SF2	TCPQM_HUMAN	T-complex protein 1	54					cellular protein metabolic process	cytoplasm	anion channel activity|ATP binding|calcium-activated potassium channel activity			ovary(1)	1	all_hematologic(4;0.00567)|Acute lymphoblastic leukemia(84;0.0977)	all_epithelial(15;0.0157)|Lung NSC(13;0.147)|all_lung(157;0.175)				TCTGCCGGCCGTGGGGGCCAT	0.637			NA											23	59					2.48779e-11	3.15264e-11	0.005443	1	0
CCT8L2	150160	broad.mit.edu	37	22	17073380	17073380	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr22:17073380C>T	uc002zlp.1	-	1	321	c.61G>A	c.(61-63)GAG>AAG	p.E21K		NM_014406	NP_055221	Q96SF2	TCPQM_HUMAN	T-complex protein 1	21					cellular protein metabolic process	cytoplasm	anion channel activity|ATP binding|calcium-activated potassium channel activity			ovary(1)	1	all_hematologic(4;0.00567)|Acute lymphoblastic leukemia(84;0.0977)	all_epithelial(15;0.0157)|Lung NSC(13;0.147)|all_lung(157;0.175)				CTCGGGCTCTCCCTTGGGTTC	0.657			NA											16	49					0	0	0.010504	0	0
CCT8L2	150160	broad.mit.edu	37	22	17073395	17073395	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr22:17073395C>T	uc002zlp.1	-	1	306	c.46G>A	c.(46-48)GCA>ACA	p.A16T		NM_014406	NP_055221	Q96SF2	TCPQM_HUMAN	T-complex protein 1	16					cellular protein metabolic process	cytoplasm	anion channel activity|ATP binding|calcium-activated potassium channel activity			ovary(1)	1	all_hematologic(4;0.00567)|Acute lymphoblastic leukemia(84;0.0977)	all_epithelial(15;0.0157)|Lung NSC(13;0.147)|all_lung(157;0.175)				GGGTTCAGTGCCAGCCGCTGG	0.647			NA											20	46					0	0	0.00333	0	0
APOBEC3F	200316	broad.mit.edu	37	22	39445556	39445556	+	Silent	SNP	C	C	G	rs34578066	by1000genomes	TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr22:39445556C>G	uc003aww.2	+	5	986	c.693C>G	c.(691-693)GTC>GTG	p.V231V		NM_145298	NP_660341	Q9HC16	ABC3G_HUMAN	apolipoprotein B mRNA editing enzyme, catalytic	233					base conversion or substitution editing|DNA cytosine deamination|innate immune response|interspecies interaction between organisms|negative regulation of retroviral genome replication|negative regulation of transposition|positive regulation of defense response to virus by host|response to virus|viral reproduction	apolipoprotein B mRNA editing enzyme complex|cytosol|mitochondrion	cytidine deaminase activity|dCTP deaminase activity|protein homodimerization activity|RNA binding|zinc ion binding				0	Melanoma(58;0.04)					ACTCACCTGTCTCCTGGAAGA	0.463			NA											30	185					0	0	0.003271	0	0
L3MBTL2	83746	broad.mit.edu	37	22	41615532	41615532	+	Missense_Mutation	SNP	A	A	T			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr22:41615532A>T	uc003azo.2	+	6	764	c.710A>T	c.(709-711)CAG>CTG	p.Q237L	L3MBTL2_uc010gyi.1_Missense_Mutation_p.Q146L|L3MBTL2_uc003azn.2_RNA|uc003azp.1_5'Flank	NM_031488	NP_113676	Q969R5	LMBL2_HUMAN	l(3)mbt-like 2	237	MBT 1.				chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	methylated histone residue binding|transcription corepressor activity|zinc ion binding			ovary(2)|central_nervous_system(1)	3						TCTGTCATCCAGACAGCAGGT	0.552			NA											18	32					0	0	0.014323	0	0
PARVB	29780	broad.mit.edu	37	22	44527413	44527413	+	Silent	SNP	C	C	T			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr22:44527413C>T	uc003ben.2	+	5	475	c.423C>T	c.(421-423)TCC>TCT	p.S141S	PARVB_uc003bem.2_Silent_p.S174S|PARVB_uc010gzn.2_Silent_p.S89S|PARVB_uc003beo.2_Silent_p.S104S	NM_013327	NP_037459	Q9HBI1	PARVB_HUMAN	parvin, beta isoform b	141	CH 1.				cell adhesion|cell junction assembly	cytoskeleton|cytosol|focal adhesion	actin binding				0		Ovarian(80;0.0246)|all_neural(38;0.0423)				TGACACAGTCCGAAATAGGGC	0.537			NA											7	50					0	0	0.00308	0	0
PFKFB4	5210	broad.mit.edu	37	3	48573763	48573763	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr3:48573763G>A	uc003ctv.2	-	8	783	c.766C>T	c.(766-768)CGG>TGG	p.R256W	PFKFB4_uc003ctw.2_Missense_Mutation_p.R65W|PFKFB4_uc010hkc.2_Missense_Mutation_p.R256W|PFKFB4_uc003ctx.2_Missense_Mutation_p.R213W|PFKFB4_uc010hkb.2_Missense_Mutation_p.R256W|PFKFB4_uc011bbm.1_Missense_Mutation_p.R245W|PFKFB4_uc011bbn.1_RNA	NM_004567	NP_004558	Q16877	F264_HUMAN	6-phosphofructo-2-kinase/fructose-2,	256	Fructose-2,6-bisphosphatase.				fructose 2,6-bisphosphate metabolic process|glycolysis	cytosol	6-phosphofructo-2-kinase activity|ATP binding|fructose-2,6-bisphosphate 2-phosphatase activity			breast(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.0003)|KIRC - Kidney renal clear cell carcinoma(197;0.00596)|Kidney(197;0.00684)		TCCCCGTGCCGGCAGAGGTAG	0.637			NA											4	291					0	0	0.009096	0	0
DAG1	1605	broad.mit.edu	37	3	49569641	49569641	+	Missense_Mutation	SNP	A	A	G			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr3:49569641A>G	uc003cxc.3	+	3	2115	c.1697A>G	c.(1696-1698)GAC>GGC	p.D566G		NM_004393	NP_004384	Q14118	DAG1_HUMAN	dystroglycan 1 preproprotein	566	Peptidase S72.				cytoskeletal anchoring at plasma membrane|interspecies interaction between organisms|microtubule anchoring|negative regulation of cell migration|negative regulation of MAPKKK cascade|negative regulation of protein kinase B signaling cascade	basement membrane|contractile ring|cytoplasm|cytoskeleton|dystrophin-associated glycoprotein complex|extracellular space|filopodium|integral to membrane|integral to membrane of membrane fraction|lamellipodium|nucleoplasm	actin binding|alpha-actinin binding|calcium ion binding|laminin-1 binding|receptor activity|structural constituent of muscle|tubulin binding|vinculin binding			ovary(2)	2				BRCA - Breast invasive adenocarcinoma(193;5.13e-05)|Kidney(197;0.00241)|KIRC - Kidney renal clear cell carcinoma(197;0.00258)		GGCCTTCCCGACAGCAGCCAC	0.597			NA											13	56					0	0	0.004007	0	0
DOCK3	1795	broad.mit.edu	37	3	51392314	51392314	+	Missense_Mutation	SNP	A	A	G			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr3:51392314A>G	uc011bds.1	+	41	4132	c.4109A>G	c.(4108-4110)AAC>AGC	p.N1370S		NM_004947	NP_004938	Q8IZD9	DOCK3_HUMAN	dedicator of cytokinesis 3	1370	DHR-2.					cytoplasm	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity|SH3 domain binding				0				BRCA - Breast invasive adenocarcinoma(193;0.00105)|KIRC - Kidney renal clear cell carcinoma(197;0.00449)|Kidney(197;0.00518)		TTGTGGCAGAACAAAGAATAC	0.512			NA											58	151					0	0	0.01441	0	0
STAB1	23166	broad.mit.edu	37	3	52553536	52553536	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr3:52553536G>A	uc003dej.2	+	50	5265	c.5191G>A	c.(5191-5193)GCC>ACC	p.A1731T	STAB1_uc003dek.1_5'UTR|STAB1_uc003del.2_5'Flank	NM_015136	NP_055951	Q9NY15	STAB1_HUMAN	stabilin 1 precursor	1731	Extracellular (Potential).|FAS1 6.				cell adhesion|cell-cell signaling|defense response to bacterium|inflammatory response|negative regulation of angiogenesis|receptor-mediated endocytosis	integral to plasma membrane	bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			large_intestine(3)|upper_aerodigestive_tract(2)|central_nervous_system(1)|breast(1)|skin(1)|pancreas(1)	9				BRCA - Breast invasive adenocarcinoma(193;1.73e-05)|Kidney(197;0.00182)|KIRC - Kidney renal clear cell carcinoma(197;0.00205)|OV - Ovarian serous cystadenocarcinoma(275;0.0482)		TGTCACCGCCGCCGCCCAGGG	0.602			NA											17	93					0	0	0.008871	0	0
ROBO2	6092	broad.mit.edu	37	3	77595510	77595510	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr3:77595510G>A	uc003dpy.3	+	7	1599	c.956G>A	c.(955-957)CGG>CAG	p.R319Q	ROBO2_uc003dpz.2_Missense_Mutation_p.R323Q|ROBO2_uc011bgj.1_RNA|ROBO2_uc011bgk.1_Missense_Mutation_p.R323Q	NM_002942	NP_002933	Q9HCK4	ROBO2_HUMAN	roundabout, axon guidance receptor, homolog 2	319	Ig-like C2-type 4.|Extracellular (Potential).				apoptosis involved in luteolysis|axon midline choice point recognition|cellular response to hormone stimulus|homophilic cell adhesion|metanephros development|negative regulation of negative chemotaxis|negative regulation of synaptogenesis|olfactory bulb interneuron development|positive regulation of axonogenesis|retinal ganglion cell axon guidance|ureteric bud development	axolemma|cell surface|integral to membrane	axon guidance receptor activity|identical protein binding			lung(5)|skin(3)|ovary(1)|large_intestine(1)|liver(1)	11				Epithelial(33;0.00199)|LUSC - Lung squamous cell carcinoma(21;0.008)|BRCA - Breast invasive adenocarcinoma(55;0.00884)|Lung(72;0.0183)|KIRC - Kidney renal clear cell carcinoma(39;0.0832)|Kidney(39;0.103)		TTTGTGGTTCGGCCAAGAGAT	0.398			NA											21	86					0	0	0.008871	0	0
ROBO2	6092	broad.mit.edu	37	3	77612382	77612382	+	Silent	SNP	G	G	T			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr3:77612382G>T	uc003dpy.3	+	11	2227	c.1584G>T	c.(1582-1584)CCG>CCT	p.P528P	ROBO2_uc003dpz.2_Silent_p.P532P|ROBO2_uc011bgj.1_RNA|ROBO2_uc011bgk.1_Silent_p.P532P	NM_002942	NP_002933	Q9HCK4	ROBO2_HUMAN	roundabout, axon guidance receptor, homolog 2	528	Extracellular (Potential).|Fibronectin type-III 1.				apoptosis involved in luteolysis|axon midline choice point recognition|cellular response to hormone stimulus|homophilic cell adhesion|metanephros development|negative regulation of negative chemotaxis|negative regulation of synaptogenesis|olfactory bulb interneuron development|positive regulation of axonogenesis|retinal ganglion cell axon guidance|ureteric bud development	axolemma|cell surface|integral to membrane	axon guidance receptor activity|identical protein binding			lung(5)|skin(3)|ovary(1)|large_intestine(1)|liver(1)	11				Epithelial(33;0.00199)|LUSC - Lung squamous cell carcinoma(21;0.008)|BRCA - Breast invasive adenocarcinoma(55;0.00884)|Lung(72;0.0183)|KIRC - Kidney renal clear cell carcinoma(39;0.0832)|Kidney(39;0.103)		CATCCAAACCGCAGGTCACTG	0.463			NA											14	33					6.31663e-08	7.46818e-08	0.003163	1	0
IMPG2	50939	broad.mit.edu	37	3	100963143	100963143	+	Nonsense_Mutation	SNP	C	C	A			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr3:100963143C>A	uc003duq.1	-	13	2235	c.2032G>T	c.(2032-2034)GAG>TAG	p.E678*	IMPG2_uc011bhe.1_Nonsense_Mutation_p.E541*	NM_016247	NP_057331	Q9BZV3	IMPG2_HUMAN	interphotoreceptor matrix proteoglycan 2	678	Extracellular (Potential).				visual perception	integral to membrane|proteinaceous extracellular matrix	extracellular matrix structural constituent|heparin binding|hyaluronic acid binding|receptor activity			ovary(2)|haematopoietic_and_lymphoid_tissue(1)	3						GGCTCTTCCTCTGGAAAGTGT	0.448			NA											17	25					9.16793e-09	1.10466e-08	0.00499	1	0
MYH15	22989	broad.mit.edu	37	3	108159970	108159970	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr3:108159970C>A	uc003dxa.1	-	24	2910	c.2853G>T	c.(2851-2853)AGG>AGT	p.R951S		NM_014981	NP_055796	Q9Y2K3	MYH15_HUMAN	myosin, heavy polypeptide 15	951	Potential.					myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			ovary(5)|central_nervous_system(2)	7						GTTTCCGCCCCCTGGCAGTCA	0.478			NA											23	94					1.9806e-07	2.3046e-07	0.014323	1	0
ARHGAP31	57514	broad.mit.edu	37	3	119134364	119134364	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr3:119134364G>T	uc003ecj.3	+	12	4120	c.3588G>T	c.(3586-3588)CAG>CAT	p.Q1196H		NM_020754	NP_065805	Q2M1Z3	RHG31_HUMAN	Cdc42 GTPase-activating protein	1196					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|focal adhesion|lamellipodium	GTPase activator activity			ovary(2)	2						AAATGTGCCAGGCCAGGGCGG	0.582	Pancreas(7;176 297 5394 51128 51241)		NA											12	78					2.32078e-09	2.83509e-09	0.003163	1	0
POLQ	10721	broad.mit.edu	37	3	121206886	121206886	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr3:121206886C>G	uc003eee.3	-	16	5021	c.4892G>C	c.(4891-4893)TGG>TCG	p.W1631S	POLQ_uc003eed.2_Missense_Mutation_p.W803S	NM_199420	NP_955452	O75417	DPOLQ_HUMAN	DNA polymerase theta	1631					DNA repair|DNA replication	nucleoplasm	ATP binding|ATP-dependent helicase activity|damaged DNA binding|DNA-directed DNA polymerase activity|single-stranded DNA-dependent ATPase activity			ovary(4)|breast(3)|lung(2)|upper_aerodigestive_tract(1)|skin(1)	11				GBM - Glioblastoma multiforme(114;0.0915)		TGCCCCTGACCATATGAATGA	0.383	Pancreas(152;907 1925 26081 31236 36904)		NA						DNA_polymerases_(catalytic_subunits)					50	130					0	0	0.01441	0	0
PARP14	54625	broad.mit.edu	37	3	122420301	122420301	+	Missense_Mutation	SNP	T	T	A			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr3:122420301T>A	uc003efq.3	+	6	2959	c.2900T>A	c.(2899-2901)GTT>GAT	p.V967D	PARP14_uc010hrk.2_RNA|PARP14_uc003efr.2_Missense_Mutation_p.V684D|PARP14_uc003efs.1_Missense_Mutation_p.V684D	NM_017554	NP_060024	Q460N5	PAR14_HUMAN	poly (ADP-ribose) polymerase family, member 14	967	Macro 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	NAD+ ADP-ribosyltransferase activity			ovary(2)|breast(2)|lung(1)|pancreas(1)	6				GBM - Glioblastoma multiforme(114;0.0531)		GAGAAGACTGTTGAGGCCTTT	0.488			NA											8	32					0	0	0.004482	0	0
RASA2	5922	broad.mit.edu	37	3	141327427	141327427	+	Nonsense_Mutation	SNP	C	C	T			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr3:141327427C>T	uc003etz.1	+	21	2113	c.2113C>T	c.(2113-2115)CGA>TGA	p.R705*	RASA2_uc010huq.1_Nonsense_Mutation_p.R709*|RASA2_uc003eua.1_Nonsense_Mutation_p.R706*	NM_006506	NP_006497	Q15283	RASA2_HUMAN	RAS p21 protein activator 2	705	PH.				intracellular signal transduction|negative regulation of Ras protein signal transduction	intracellular membrane-bounded organelle|intrinsic to internal side of plasma membrane|perinuclear region of cytoplasm	metal ion binding|Ras GTPase activator activity			ovary(2)|lung(2)|breast(1)|skin(1)	6						CAGGGTGAGCCGATGCAATCA	0.448			NA											6	32					0	0	0.004482	0	0
ZBBX	79740	broad.mit.edu	37	3	167068302	167068302	+	Missense_Mutation	SNP	A	A	T			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr3:167068302A>T	uc003fep.2	-	9	757	c.434T>A	c.(433-435)GTA>GAA	p.V145E	ZBBX_uc011bpc.1_Missense_Mutation_p.V145E|ZBBX_uc003feq.2_Missense_Mutation_p.V116E	NM_024687	NP_078963	A8MT70	ZBBX_HUMAN	zinc finger, B-box domain containing	145	B box-type; atypical.					intracellular	zinc ion binding			ovary(2)	2						TTCAAGGCATACCTAAAAAGa	0.289			NA											16	30					0	0	0.003163	0	0
ZBBX	79740	broad.mit.edu	37	3	167086333	167086333	+	Missense_Mutation	SNP	A	A	T			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr3:167086333A>T	uc003fep.2	-	5	421	c.98T>A	c.(97-99)GTA>GAA	p.V33E	ZBBX_uc011bpc.1_Missense_Mutation_p.V33E|ZBBX_uc003feq.2_Missense_Mutation_p.V4E	NM_024687	NP_078963	A8MT70	ZBBX_HUMAN	zinc finger, B-box domain containing	33	Potential.					intracellular	zinc ion binding			ovary(2)	2						CTCTAACTGTACTTTCTCCAT	0.343			NA											15	22					0	0	0.00499	0	0
PIK3CA	5290	broad.mit.edu	37	3	178936091	178936091	+	Missense_Mutation	SNP	G	G	A	rs104886003		TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr3:178936091G>A	uc003fjk.2	+	10	1790	c.1633G>A	c.(1633-1635)GAG>AAG	p.E545K		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	545	PI3K helical.		E -> G (in KERSEB).|E -> A (in cancer).|E -> K (in KERSEB; shows an increase in lipid kinase activity; oncogenic in vivo; occurs in the interface between the PI3K helical domain and the nSH2 (N-terminal SH2) region of the p85 regulatory subunit and may reduce the inhibitory effect of p85; requires interaction with RAS to induce cellular transformation; enhances invadopodia-mediated extracellular matrix degradation and invasion in breast cancer cells).		epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.E545K(735)|p.E545A(75)|p.E545G(55)|p.E545?(19)|p.E545D(15)|p.E545Q(12)|p.E545V(4)		breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			TGAAATCACTGAGCAGGAGAA	0.353	Colon(199;1504 1750 3362 26421 31210 32040)	E545K(RERFLCSQ1_LUNG)|E545K(KYSE510_OESOPHAGUS)|E545K(NCIH508_LARGE_INTESTINE)|E545K(HCC202_BREAST)|E545K(BFTC909_KIDNEY)|E545K(HCT15_LARGE_INTESTINE)|E545K(NCIH596_LUNG)|E545K(L363_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|E545K(DLD1_LARGE_INTESTINE)|E545K(ESS1_ENDOMETRIUM)|E545K(MDAMB361_BREAST)|E545K(MKN1_STOMACH)|E545K(MCF7_BREAST)|E545K(NCIH460_LUNG)|E545K(TCCSUP_URINARY_TRACT)|E545K(HSC4_UPPER_AERODIGESTIVE_TRACT)|E545K(BC3C_URINARY_TRACT)|E545K(HUH28_BILIARY_TRACT)|E545K(HT1197_URINARY_TRACT)|E545K(TE5_OESOPHAGUS)	57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			4	12					0	0	0.001168	0	0
YEATS2	55689	broad.mit.edu	37	3	183432964	183432964	+	Missense_Mutation	SNP	A	A	T			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr3:183432964A>T	uc003fly.2	+	2	209	c.14A>T	c.(13-15)AAG>ATG	p.K5M		NM_018023	NP_060493	Q9ULM3	YETS2_HUMAN	YEATS domain containing 2	5					histone H3 acetylation|negative regulation of transcription from RNA polymerase II promoter	Ada2/Gcn5/Ada3 transcription activator complex	TBP-class protein binding			ovary(3)|large_intestine(1)	4	all_cancers(143;6.55e-10)|Ovarian(172;0.0303)		all cancers(12;2.38e-42)|Epithelial(37;1.9e-36)|OV - Ovarian serous cystadenocarcinoma(80;6.48e-22)			TCTGGAATCAAGCGAACCATC	0.378			NA											38	48					0	0	0.006999	0	0
OSTalpha	200931	broad.mit.edu	37	3	195953990	195953990	+	Silent	SNP	G	G	A	rs139345051		TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr3:195953990G>A	uc003fwd.2	+	3	489	c.288G>A	c.(286-288)ACG>ACA	p.T96T	OSTalpha_uc011btu.1_Silent_p.T96T|OSTalpha_uc010iac.1_5'Flank|OSTalpha_uc003fwe.2_5'Flank	NM_152672	NP_689885	Q86UW1	OSTA_HUMAN	organic solute transporter alpha	96	Helical; (Potential).					integral to membrane|plasma membrane	transporter activity			ovary(1)	1	all_cancers(143;1.68e-08)|Ovarian(172;0.0634)|Breast(254;0.206)		Epithelial(36;8.83e-25)|all cancers(36;8.38e-23)|OV - Ovarian serous cystadenocarcinoma(49;7.08e-19)|LUSC - Lung squamous cell carcinoma(58;7.51e-07)|Lung(62;1.06e-06)	GBM - Glioblastoma multiforme(46;0.00202)		CGGCACCCACGGTGAGGCCCC	0.577			NA											21	103					0	0	0.005443	0	0
PDE6B	5158	broad.mit.edu	37	4	647926	647926	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr4:647926C>A	uc003gap.2	+	5	963	c.910C>A	c.(910-912)CGC>AGC	p.R304S	PDE6B_uc003gao.3_Missense_Mutation_p.R304S|PDE6B_uc011buy.1_Missense_Mutation_p.R25S|PDE6B_uc010ibg.2_Missense_Mutation_p.R25S|uc003gaq.1_RNA	NM_000283	NP_000274	P35913	PDE6B_HUMAN	phosphodiesterase 6B isoform 1	304	GAF 2.				cytosolic calcium ion homeostasis|GMP metabolic process|phototransduction, visible light|platelet activation|visual perception	cytosol|membrane	3',5'-cyclic-GMP phosphodiesterase activity|metal ion binding				0						CTCGGGCCCACGCACGCCTGA	0.642	GBM(71;463 1194 9848 25922 46834)		NA											21	49					8.16277e-20	1.19594e-19	0.006999	1	0
DCAF16	54876	broad.mit.edu	37	4	17805366	17805366	+	Silent	SNP	C	C	A			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr4:17805366C>A	uc003gpn.2	-	3	1460	c.399G>T	c.(397-399)CGG>CGT	p.R133R	DCAF16_uc003gpo.2_RNA	NM_017741	NP_060211	Q9NXF7	DCA16_HUMAN	DDB1 and CUL4 associated factor 16	133						CUL4 RING ubiquitin ligase complex				ovary(1)	1						CTCTAGAGAGCCGGCTGGGAC	0.502			NA											75	144					1.32764e-51	2.28707e-51	0.01441	1	0
PCDH7	5099	broad.mit.edu	37	4	31144129	31144129	+	Silent	SNP	G	G	T			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr4:31144129G>T	uc011bxx.1	+	3	4410	c.3402G>T	c.(3400-3402)GGG>GGT	p.G1134G	PCDH7_uc011bxw.1_Silent_p.G1087G	NM_002589	NP_002580	O60245	PCDH7_HUMAN	protocadherin 7 isoform a precursor	Error:Variant_position_missing_in_O60245_after_alignment					homophilic cell adhesion	integral to plasma membrane	calcium ion binding			upper_aerodigestive_tract(1)|ovary(1)|liver(1)|skin(1)	4						CCCTGACTGGGAAGTGCACTC	0.512			NA											22	99					1.55469e-16	2.1835e-16	0.00333	1	0
KLB	152831	broad.mit.edu	37	4	39408690	39408691	+	Missense_Mutation	DNP	CT	CT	AA			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	CT	CT	-	-	CT	CT	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr4:39408690_39408691CT>AA	uc003gua.2	+	1	218_219	c.121_122CT>AA	c.(121-123)CTG>AAG	p.L41K	KLB_uc011byj.1_Missense_Mutation_p.L41K	NM_175737	NP_783864	Q86Z14	KLOTB_HUMAN	klotho beta	41	Extracellular (Potential).				carbohydrate metabolic process	integral to membrane|plasma membrane	cation binding|fibroblast growth factor binding|hydrolase activity, hydrolyzing O-glycosyl compounds			skin(1)	1						ATCTGTCATCCTGTCAGCACTT	0.416			NA											26	84					0	0	0.004672	0	0
ATP10D	57205	broad.mit.edu	37	4	47556801	47556801	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr4:47556801G>T	uc003gxk.1	+	11	1858	c.1694G>T	c.(1693-1695)CGG>CTG	p.R565L	ATP10D_uc003gxl.1_Intron	NM_020453	NP_065186	Q9P241	AT10D_HUMAN	ATPase, class V, type 10D	565	Cytoplasmic (Potential).				ATP biosynthetic process|cation transport	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(2)|pancreas(1)	3						ATTACACCTCGGCTCTTTATG	0.388			NA											25	94					7.07758e-08	8.34549e-08	0.004656	1	0
GC	2638	broad.mit.edu	37	4	72631270	72631270	+	Nonsense_Mutation	SNP	C	C	A			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr4:72631270C>A	uc003hge.2	-	4	505	c.352G>T	c.(352-354)GAA>TAA	p.E118*	GC_uc003hgd.2_5'UTR|GC_uc010iie.2_Nonsense_Mutation_p.E118*|GC_uc010iif.2_Nonsense_Mutation_p.E137*	NM_000583	NP_000574	P02774	VTDB_HUMAN	vitamin D-binding protein precursor	118	Albumin 1.				hormone biosynthetic process|vitamin D metabolic process	cytosol|lysosomal lumen	actin binding|vitamin D binding|vitamin transporter activity			ovary(2)|upper_aerodigestive_tract(1)	3		all_hematologic(202;0.107)	Lung(101;0.148)		Cholecalciferol(DB00169)	AGCTTTCGTTCCAGGCCCTCT	0.527			NA											28	75					5.60225e-13	7.41919e-13	0.009535	1	0
HELQ	113510	broad.mit.edu	37	4	84348734	84348734	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr4:84348734C>A	uc003hom.2	-	13	2837	c.2658G>T	c.(2656-2658)TGG>TGT	p.W886C	HELQ_uc010ikb.2_Missense_Mutation_p.W819C|HELQ_uc003hol.3_RNA|HELQ_uc010ikc.2_RNA	NM_133636	NP_598375	Q8TDG4	HELQ_HUMAN	DNA helicase HEL308	886							ATP binding|ATP-dependent helicase activity|nucleic acid binding			ovary(1)|breast(1)|skin(1)	3						AGTATATCATCCAATCAGGGT	0.338			NA						Direct_reversal_of_damage|Other_identified_genes_with_known_or_suspected_DNA_repair_function					32	77					3.03874e-20	4.48189e-20	0.003271	1	0
CFI	3426	broad.mit.edu	37	4	110687980	110687980	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr4:110687980C>G	uc003hzr.3	-	2	266	c.58G>C	c.(58-60)GTC>CTC	p.V20L	CFI_uc011cft.1_Missense_Mutation_p.V20L|CFI_uc003hzs.3_Missense_Mutation_p.V20L	NM_000204	NP_000195	P05156	CFAI_HUMAN	complement factor I preproprotein	20					complement activation, classical pathway|innate immune response|proteolysis	extracellular space|membrane	scavenger receptor activity|serine-type endopeptidase activity				0		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.000331)		GTATAAGTGACCTGTAAAATG	0.388			NA											8	55					0	0	0.006214	0	0
ENPEP	2028	broad.mit.edu	37	4	111430928	111430928	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr4:111430928G>T	uc003iab.3	+	5	1501	c.1159G>T	c.(1159-1161)GTG>TTG	p.V387L		NM_001977	NP_001968	Q07075	AMPE_HUMAN	glutamyl aminopeptidase	387	Extracellular (Potential).				cell migration|cell proliferation|cell-cell signaling|proteolysis	integral to plasma membrane	aminopeptidase activity|metalloexopeptidase activity|zinc ion binding			skin(3)|ovary(1)|breast(1)	5		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.0031)	L-Glutamic Acid(DB00142)	CCAACAGAGGGTGGCCACTGT	0.458			NA											36	58					3.61848e-18	5.17398e-18	0.007835	1	0
ALPK1	80216	broad.mit.edu	37	4	113356422	113356422	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr4:113356422G>T	uc003iap.3	+	12	3432	c.3153G>T	c.(3151-3153)TGG>TGT	p.W1051C	ALPK1_uc003ian.3_Missense_Mutation_p.W1051C|ALPK1_uc011cfx.1_Missense_Mutation_p.W973C|ALPK1_uc003iao.3_RNA|ALPK1_uc010imo.2_Missense_Mutation_p.W879C	NM_025144	NP_079420	Q96QP1	ALPK1_HUMAN	alpha-kinase 1	1051	Alpha-type protein kinase.						ATP binding|protein serine/threonine kinase activity			ovary(5)	5		Ovarian(17;0.0446)|Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.00325)		ATGCTTTTTGGGTTCATCATC	0.358			NA											76	142					4.97629e-18	7.05641e-18	0.01441	1	0
FAT4	79633	broad.mit.edu	37	4	126239750	126239750	+	Missense_Mutation	SNP	A	A	G			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr4:126239750A>G	uc003ifj.3	+	1	2184	c.2184A>G	c.(2182-2184)ATA>ATG	p.I728M		NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	728	Cadherin 7.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18						AATATAGCATATCTGCTGGGG	0.468			NA											20	92					0	0	0.012319	0	0
LRBA	987	broad.mit.edu	37	4	151773298	151773298	+	Silent	SNP	T	T	A			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr4:151773298T>A	uc010ipj.2	-	23	4038	c.3564A>T	c.(3562-3564)TCA>TCT	p.S1188S	LRBA_uc003ilt.3_5'Flank|LRBA_uc003ilu.3_Silent_p.S1188S	NM_006726	NP_006717	P50851	LRBA_HUMAN	LPS-responsive vesicle trafficking, beach and	1188						endoplasmic reticulum|Golgi apparatus|integral to membrane|lysosome|plasma membrane	protein binding			ovary(3)|breast(3)|skin(1)	7	all_hematologic(180;0.151)					GTGACATAGCTGAAGACCCTG	0.398			NA											18	47					0	0	0.010504	0	0
FHDC1	85462	broad.mit.edu	37	4	153864685	153864685	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr4:153864685C>T	uc003inf.2	+	1	551	c.476C>T	c.(475-477)TCC>TTC	p.S159F		NM_033393	NP_203751	Q9C0D6	FHDC1_HUMAN	FH2 domain containing 1	159	FH2.				actin cytoskeleton organization		actin binding			large_intestine(1)|ovary(1)	2	all_hematologic(180;0.093)					TTAAATTCATCCTTCAGAGAA	0.438			NA											21	93					0	0	0.010504	0	0
SPOCK3	50859	broad.mit.edu	37	4	167656177	167656177	+	Silent	SNP	C	C	T			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr4:167656177C>T	uc003iri.1	-	12	1347	c.1206G>A	c.(1204-1206)GAG>GAA	p.E402E	SPOCK3_uc011cjp.1_Silent_p.E359E|SPOCK3_uc011cjq.1_Silent_p.E411E|SPOCK3_uc011cjr.1_Silent_p.E282E|SPOCK3_uc003irj.1_Silent_p.E399E|SPOCK3_uc011cjs.1_Silent_p.E351E|SPOCK3_uc011cjt.1_Silent_p.E310E|SPOCK3_uc011cju.1_Silent_p.E295E|SPOCK3_uc011cjv.1_Silent_p.E304E	NM_016950	NP_058646	Q9BQ16	TICN3_HUMAN	testican 3 isoform 2	402	Asp-rich.				signal transduction	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase inhibitor activity	p.E402*(1)		large_intestine(1)|ovary(1)|central_nervous_system(1)	3	all_hematologic(180;0.221)	Prostate(90;0.0181)|Renal(120;0.0184)|Melanoma(52;0.0198)		GBM - Glioblastoma multiforme(119;0.02)		cttcatcatcctcatcatcag	0.09			NA											4	6					0	0	0.000602	0	0
ODZ3	55714	broad.mit.edu	37	4	183676073	183676073	+	Missense_Mutation	SNP	A	A	C			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr4:183676073A>C	uc003ivd.1	+	21	4590	c.4553A>C	c.(4552-4554)GAT>GCT	p.D1518A	ODZ3_uc003ive.1_Missense_Mutation_p.D931A	NM_001080477	NP_001073946	Q9P273	TEN3_HUMAN	odz, odd Oz/ten-m homolog 3	1518	Extracellular (Potential).|YD 1.				signal transduction	integral to membrane					0		all_lung(41;2.69e-14)|Lung NSC(41;1.92e-11)|Melanoma(52;1.74e-05)|Colorectal(36;0.0062)|Breast(14;0.00748)|all_hematologic(60;0.0162)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|all_neural(102;0.155)|Medulloblastoma(177;0.184)		all cancers(43;1.42e-24)|Epithelial(43;6.86e-23)|OV - Ovarian serous cystadenocarcinoma(60;2.16e-11)|Colorectal(24;9.75e-06)|STAD - Stomach adenocarcinoma(60;2.96e-05)|COAD - Colon adenocarcinoma(29;0.00103)|GBM - Glioblastoma multiforme(59;0.00462)|LUSC - Lung squamous cell carcinoma(40;0.0391)|READ - Rectum adenocarcinoma(43;0.0487)		TCTCCAACTGATCAAGAACTC	0.378			NA											20	57					0	0	0.010504	0	0
EXOC3	11336	broad.mit.edu	37	5	454086	454086	+	Silent	SNP	G	G	T			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr5:454086G>T	uc003jba.2	+	4	1094	c.966G>T	c.(964-966)CGG>CGT	p.R322R		NM_007277	NP_009208	O60645	EXOC3_HUMAN	Sec6 protein	333					exocytosis|protein transport						0		Ovarian(839;0.0563)	Epithelial(17;0.000529)|OV - Ovarian serous cystadenocarcinoma(19;0.00153)|all cancers(22;0.00186)|Lung(60;0.0863)			TGAGCACGCGGATGCAGGACC	0.517			NA											6	38					0.000157383	0.000168053	0.00308	1	0
ADAMTS12	81792	broad.mit.edu	37	5	33577084	33577084	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr5:33577084G>T	uc003jia.1	-	19	3210	c.3047C>A	c.(3046-3048)CCA>CAA	p.P1016Q	ADAMTS12_uc010iuq.1_Missense_Mutation_p.P931Q	NM_030955	NP_112217	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1	1016	Spacer 2.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|kidney(1)	9						TAGTGTTGGTGGGTTTTTTCC	0.537			NA								HNSCC(64;0.19)			31	158					4.02929e-09	4.89508e-09	0.010818	1	0
ADAMTS12	81792	broad.mit.edu	37	5	33683976	33683976	+	Silent	SNP	G	G	T			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr5:33683976G>T	uc003jia.1	-	4	982	c.819C>A	c.(817-819)ACC>ACA	p.T273T	ADAMTS12_uc010iuq.1_Silent_p.T273T	NM_030955	NP_112217	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1	273	Peptidase M12B.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|kidney(1)	9						TGTTCATGATGGTGAGGATGT	0.463			NA								HNSCC(64;0.19)			25	59					1.04121e-07	1.22121e-07	0.005443	1	0
HEATR7B2	133558	broad.mit.edu	37	5	41004553	41004553	+	Silent	SNP	A	A	G			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr5:41004553A>G	uc003jmj.3	-	37	4579	c.4089T>C	c.(4087-4089)TGT>TGC	p.C1363C	HEATR7B2_uc003jmi.3_Silent_p.C918C	NM_173489	NP_775760	Q7Z745	HTRB2_HUMAN	HEAT repeat family member 7B2	1363	HEAT 15.						binding			ovary(6)|central_nervous_system(2)	8						TCAAGCTTTCACAGACGACTT	0.423			NA											32	91					0	0	0.012213	0	0
ITGA2	3673	broad.mit.edu	37	5	52360751	52360751	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr5:52360751G>T	uc003joy.2	+	14	1755	c.1612G>T	c.(1612-1614)GGT>TGT	p.G538C	ITGA2_uc011cqa.1_RNA|ITGA2_uc011cqb.1_RNA|ITGA2_uc011cqc.1_Missense_Mutation_p.G462C|ITGA2_uc011cqd.1_RNA|ITGA2_uc011cqe.1_RNA	NM_002203	NP_002194	P17301	ITA2_HUMAN	integrin alpha 2 precursor	538	FG-GAP 5.|Extracellular (Potential).				axon guidance|blood coagulation|cell-matrix adhesion|integrin-mediated signaling pathway|interspecies interaction between organisms|organ morphogenesis	integrin complex	collagen binding|identical protein binding|receptor activity			lung(1)	1		Lung NSC(810;3.11e-05)|Breast(144;0.014)|Prostate(461;0.0181)				GGGCATTTTGGGTCAGCACCA	0.358			NA											21	47					1.50039e-11	1.92347e-11	0.012319	1	0
FST	10468	broad.mit.edu	37	5	52778792	52778792	+	Nonsense_Mutation	SNP	C	C	A			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr5:52778792C>A	uc003jpd.2	+	2	195	c.168C>A	c.(166-168)TGC>TGA	p.C56*	FST_uc003jpc.2_Nonsense_Mutation_p.C56*	NM_013409	NP_037541	P19883	FST_HUMAN	follistatin isoform FST344 precursor	56	TB.				hemopoietic progenitor cell differentiation|negative regulation of activin receptor signaling pathway|negative regulation of follicle-stimulating hormone secretion|negative regulation of transcription from RNA polymerase II promoter|positive regulation of hair follicle development	extracellular region	activin binding|protein binding|signal transducer activity				0		Ovarian(174;1.78e-06)|Lung NSC(810;3.55e-06)|Breast(144;4.08e-05)				AGGAGTGCTGCAGCACCGGCC	0.597			NA									OREG0016608	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	24	43					3.1745e-13	4.22946e-13	0.008361	1	0
SKIV2L2	23517	broad.mit.edu	37	5	54654435	54654435	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr5:54654435G>C	uc003jpy.3	+	15	1834	c.1568G>C	c.(1567-1569)CGT>CCT	p.R523P	SKIV2L2_uc011cqi.1_Missense_Mutation_p.R422P	NM_015360	NP_056175	P42285	SK2L2_HUMAN	superkiller viralicidic activity 2-like 2	523	Helicase C-terminal.				maturation of 5.8S rRNA	catalytic step 2 spliceosome|nucleolus	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			ovary(1)|skin(1)	2		Lung NSC(810;0.000744)|Breast(144;0.181)|Prostate(74;0.194)				ATGTCTGGTCGTGCTGGAAGG	0.323	Melanoma(2;92 134 23744 29976 33782)		NA											4	39					0	0	0.00308	0	0
SV2C	22987	broad.mit.edu	37	5	75427939	75427939	+	Nonsense_Mutation	SNP	G	G	T			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr5:75427939G>T	uc003kei.1	+	2	498	c.364G>T	c.(364-366)GAG>TAG	p.E122*		NM_014979	NP_055794	Q496J9	SV2C_HUMAN	synaptic vesicle glycoprotein 2C	122	Cytoplasmic (Potential).				neurotransmitter transport	cell junction|integral to membrane|synaptic vesicle membrane	transmembrane transporter activity			skin(1)	1		all_lung(232;0.007)|Lung NSC(167;0.0148)|Ovarian(174;0.0798)|Prostate(461;0.184)		OV - Ovarian serous cystadenocarcinoma(47;1.16e-50)|all cancers(79;7.25e-40)		GGACCGGCGGGAGCTGGAATC	0.547			NA											19	35					3.62473e-10	4.52835e-10	0.012319	1	0
THBS4	7060	broad.mit.edu	37	5	79375018	79375018	+	Silent	SNP	G	G	A			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr5:79375018G>A	uc003kgh.2	+	20	2771	c.2448G>A	c.(2446-2448)ACG>ACA	p.T816T	uc003kgi.3_Intron	NM_003248	NP_003239	P35443	TSP4_HUMAN	thrombospondin 4 precursor	816	TSP C-terminal.				endothelial cell-cell adhesion|myoblast migration|negative regulation of angiogenesis|positive regulation of endothelial cell proliferation|positive regulation of neutrophil chemotaxis|positive regulation of peptidyl-tyrosine phosphorylation	basement membrane|extracellular space	calcium ion binding|heparin binding|integrin binding|structural molecule activity				0		Lung NSC(167;0.00328)|all_lung(232;0.00355)|Ovarian(174;0.0261)		OV - Ovarian serous cystadenocarcinoma(54;6.3e-45)|Epithelial(54;1.77e-39)|all cancers(79;3.2e-34)		GGAAGCAGACGGAGCAGACAT	0.488			NA											10	66					0	0	0.00245	0	0
PCDHA2	56146	broad.mit.edu	37	5	140176000	140176000	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr5:140176000C>A	uc003lhd.2	+	1	1557	c.1451C>A	c.(1450-1452)GCG>GAG	p.A484E	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhc.1_Missense_Mutation_p.A484E|PCDHA2_uc011czy.1_Missense_Mutation_p.A484E	NM_018905	NP_061728	Q9Y5H9	PCDA2_HUMAN	protocadherin alpha 2 isoform 1 precursor	484	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(4)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GATGCGGACGCGCAGGAGAAC	0.657			NA											34	99					1.21353e-23	1.84541e-23	0.01441	1	0
PCDHA12	56137	broad.mit.edu	37	5	140256796	140256796	+	Nonsense_Mutation	SNP	T	T	A			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr5:140256796T>A	uc003lic.2	+	1	1866	c.1739T>A	c.(1738-1740)TTG>TAG	p.L580*	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc003lia.2_Intron|PCDHA12_uc011daf.1_Nonsense_Mutation_p.L580*	NM_018903	NP_061726	Q9UN75	PCDAC_HUMAN	protocadherin alpha 12 isoform 1 precursor	580	Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GTTAGCGAGTTGGTACCGCGG	0.662	Pancreas(113;759 1672 13322 24104 50104)		NA											49	107					0	0	0.01441	0	0
PCDHB16	57717	broad.mit.edu	37	5	140564342	140564342	+	Silent	SNP	G	G	T			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr5:140564342G>T	uc003liv.2	+	1	3363	c.2208G>T	c.(2206-2208)CTG>CTT	p.L736L	PCDHB9_uc003liw.1_5'Flank	NM_020957	NP_066008	Q9NRJ7	PCDBG_HUMAN	protocadherin beta 16 precursor	736	Cytoplasmic (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			ovary(1)|pancreas(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CAGGGCGTCTGGTGGACGTAA	0.632			NA											38	160					2.40579e-17	3.40049e-17	0.00623	1	0
PCDHGA10	56106	broad.mit.edu	37	5	140793377	140793377	+	Missense_Mutation	SNP	A	A	G			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr5:140793377A>G	uc003lkl.1	+	1	635	c.635A>G	c.(634-636)CAC>CGC	p.H212R	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc003lkh.1_Intron|PCDHGB6_uc003lkj.1_Intron|PCDHGA10_uc011day.1_Missense_Mutation_p.H212R	NM_018913	NP_061736	Q9Y5H3	PCDGA_HUMAN	protocadherin gamma subfamily A, 10 isoform 1	212	Extracellular (Potential).|Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GAGGCCATTCACCACCTGGTC	0.582			NA											30	65					0	0	0.012213	0	0
PCDHGB7	56099	broad.mit.edu	37	5	140797646	140797646	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr5:140797646C>A	uc003lkn.1	+	1	365	c.220C>A	c.(220-222)CAC>AAC	p.H74N	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc003lkh.1_Intron|PCDHGB6_uc003lkj.1_Intron|PCDHGA10_uc003lkl.1_Intron|PCDHGB7_uc003lkm.2_Missense_Mutation_p.H74N|PCDHGA11_uc003lko.1_5'Flank|PCDHGA11_uc003lkp.1_5'Flank|PCDHGA11_uc003lkq.1_5'Flank	NM_018927	NP_061750	Q9Y5F8	PCDGJ_HUMAN	protocadherin gamma subfamily B, 7 isoform 1	74	Extracellular (Potential).|Cadherin 1.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGAGAAGCTGCACTTCAGCGT	0.562			NA											37	88					3.62531e-18	5.17398e-18	0.004289	1	0
FBXO38	81545	broad.mit.edu	37	5	147796641	147796641	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr5:147796641G>T	uc003lpf.1	+	12	1612	c.1492G>T	c.(1492-1494)GAT>TAT	p.D498Y	FBXO38_uc003lpg.1_Missense_Mutation_p.D498Y|FBXO38_uc003lph.2_Missense_Mutation_p.D498Y	NM_205836	NP_995308	Q6PIJ6	FBX38_HUMAN	F-box protein 38 isoform b	498				D -> E (in Ref. 1; AAH33454).		cytoplasm|nucleus				ovary(4)|skin(2)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CAACAATGACGATAATAATGC	0.463			NA											8	25					3.09899e-07	3.54975e-07	0.004482	1	0
CSF1R	1436	broad.mit.edu	37	5	149435795	149435795	+	Missense_Mutation	SNP	A	A	G			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr5:149435795A>G	uc003lrl.2	-	17	2624	c.2429T>C	c.(2428-2430)ATT>ACT	p.I810T	CSF1R_uc011dcd.1_Intron|CSF1R_uc010jhc.2_RNA|CSF1R_uc003lrm.2_Missense_Mutation_p.I810T	NM_005211	NP_005202	P07333	CSF1R_HUMAN	colony stimulating factor 1 receptor precursor	810	Protein kinase.|Cytoplasmic (Potential).				cell proliferation|multicellular organismal development|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane|receptor complex	ATP binding|cytokine binding|macrophage colony-stimulating factor receptor activity|protein homodimerization activity			haematopoietic_and_lymphoid_tissue(38)|lung(6)|central_nervous_system(3)|liver(3)|breast(2)|endometrium(1)|ovary(1)	54			KIRC - Kidney renal clear cell carcinoma(527;0.000962)|Kidney(363;0.00147)		Imatinib(DB00619)|Sunitinib(DB01268)	GCCCTTGACAATGTAGTTGGA	0.592			NA											78	113					0	0	0.01441	0	0
ODZ2	57451	broad.mit.edu	37	5	167674480	167674480	+	Missense_Mutation	SNP	A	A	G			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr5:167674480A>G	uc010jjd.2	+	27	6509	c.6509A>G	c.(6508-6510)TAT>TGT	p.Y2170C	ODZ2_uc003lzr.3_Missense_Mutation_p.Y1940C|ODZ2_uc003lzt.3_Missense_Mutation_p.Y1543C|ODZ2_uc010jje.2_Missense_Mutation_p.Y1434C	NM_001122679	NP_001116151			odz, odd Oz/ten-m homolog 2											ovary(6)|central_nervous_system(4)	10	Renal(175;0.00124)|Lung NSC(126;0.136)|all_lung(126;0.242)	Medulloblastoma(196;0.0241)|all_neural(177;0.026)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0444)|OV - Ovarian serous cystadenocarcinoma(192;0.0694)|Epithelial(171;0.124)		ACGGTGCAATATGACAGCATG	0.552			NA											24	71					0	0	0.005443	0	0
NSD1	64324	broad.mit.edu	37	5	176665401	176665401	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr5:176665401G>C	uc003mfr.3	+	7	4223	c.4085G>C	c.(4084-4086)GGA>GCA	p.G1362A	NSD1_uc003mft.3_Missense_Mutation_p.G1093A|NSD1_uc003mfs.1_Missense_Mutation_p.G1259A|NSD1_uc011dfx.1_Missense_Mutation_p.G1010A	NM_022455	NP_071900	Q96L73	NSD1_HUMAN	nuclear receptor binding SET domain protein 1	1362					negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	androgen receptor binding|chromatin binding|estrogen receptor binding|histone methyltransferase activity (H3-K36 specific)|histone methyltransferase activity (H4-K20 specific)|ligand-dependent nuclear receptor binding|retinoid X receptor binding|thyroid hormone receptor binding|transcription corepressor activity|zinc ion binding			ovary(2)|kidney(1)	3	all_cancers(89;1.57e-05)|Renal(175;0.000269)|Lung NSC(126;0.00111)|all_lung(126;0.002)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)|Epithelial(233;0.198)	Kidney(146;0.235)		TCAGAACTTGGAGGTGGACAT	0.532			NA	T	NUP98	AML		Sotos Syndrome		Beckwith-Wiedemann_syndrome|Sotos_syndrome|Weaver_syndrome	HNSCC(47;0.14)			3	148					0	0	0.004672	0	0
CANX	821	broad.mit.edu	37	5	179149988	179149988	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr5:179149988G>T	uc003mkk.2	+	11	1543	c.1366G>T	c.(1366-1368)GGC>TGC	p.G456C	CANX_uc011dgp.1_Missense_Mutation_p.G491C|CANX_uc003mkl.2_Missense_Mutation_p.G456C|CANX_uc011dgq.1_Missense_Mutation_p.G348C	NM_001746	NP_001737	P27824	CALX_HUMAN	calnexin precursor	456	Lumenal (Potential).				post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine|protein secretion	endoplasmic reticulum lumen|endoplasmic reticulum membrane|integral to membrane|melanosome	calcium ion binding|sugar binding|unfolded protein binding				0	all_cancers(89;0.000129)|all_epithelial(37;5.59e-05)|Renal(175;0.000159)|Lung NSC(126;0.00121)|all_lung(126;0.00218)	all_cancers(40;0.0413)|Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)		Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Reteplase(DB00015)|Tenecteplase(DB00031)	TGATGGATGGGGCCTGAAGAA	0.438			NA											22	129					2.48779e-11	3.15264e-11	0.005443	1	0
GABBR1	2550	broad.mit.edu	37	6	29574725	29574725	+	Silent	SNP	G	G	A			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr6:29574725G>A	uc003nmt.3	-	18	2502	c.2166C>T	c.(2164-2166)GTC>GTT	p.V722V	GABBR1_uc003nmp.3_Silent_p.V605V|GABBR1_uc003nms.3_Silent_p.V605V|GABBR1_uc003nmu.3_Silent_p.V660V|GABBR1_uc011dlr.1_Silent_p.V545V	NM_001470	NP_001461	Q9UBS5	GABR1_HUMAN	gamma-aminobutyric acid (GABA) B receptor 1	722	Helical; Name=4; (Potential).				gamma-aminobutyric acid signaling pathway|negative regulation of adenylate cyclase activity|synaptic transmission	cell junction|extracellular region|integral to plasma membrane|postsynaptic membrane	G-protein coupled receptor activity|GABA-B receptor activity			ovary(5)|liver(1)|skin(1)	7					Baclofen(DB00181)|Progabide(DB00837)	CGAGAGTGAGGACATCCATGC	0.572			NA											35	94					0	0	0.005524	0	0
SLC44A4	80736	broad.mit.edu	37	6	31843659	31843659	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr6:31843659G>A	uc010jti.2	-	4	278	c.212C>T	c.(211-213)ACT>ATT	p.T71I	SLC44A4_uc011dol.1_5'UTR|SLC44A4_uc011dom.1_Missense_Mutation_p.T71I	NM_025257	NP_079533	Q53GD3	CTL4_HUMAN	choline transporter-like protein 4	71	Extracellular (Potential).					integral to membrane|plasma membrane	choline transmembrane transporter activity			large_intestine(2)|ovary(1)|central_nervous_system(1)	4					Choline(DB00122)	GTAGGCCCCAGTAGAGTTCCT	0.602			NA											143	296					0	0	0.01441	0	0
KCNK17	89822	broad.mit.edu	37	6	39278775	39278775	+	Silent	SNP	G	G	A			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr6:39278775G>A	uc003ooo.2	-	2	386	c.246C>T	c.(244-246)GTC>GTT	p.V82V	KCNK17_uc003oop.2_Silent_p.V82V	NM_031460	NP_113648	Q96T54	KCNKH_HUMAN	potassium channel, subfamily K, member 17	82						integral to membrane	potassium channel activity|voltage-gated ion channel activity			skin(2)	2						TGTATGCTTGGACGACATCCT	0.493			NA											43	122					0	0	0.010771	0	0
KIF6	221458	broad.mit.edu	37	6	39330242	39330242	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr6:39330242C>A	uc003oot.2	-	17	2009	c.1914G>T	c.(1912-1914)AAG>AAT	p.K638N	KIF6_uc003oos.2_Missense_Mutation_p.K89N|KIF6_uc010jwz.1_Missense_Mutation_p.K13N|KIF6_uc010jxa.1_Missense_Mutation_p.K429N|KIF6_uc011dua.1_Missense_Mutation_p.K621N|KIF6_uc010jxb.1_Missense_Mutation_p.K582N	NM_145027	NP_659464	Q6ZMV9	KIF6_HUMAN	kinesin family member 6	638	Potential.				microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity|protein binding			breast(2)|central_nervous_system(1)	3						GTGATCGCAGCTTCTCCTCCT	0.547			NA									OREG0017415	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	45	224					6.27289e-28	9.95088e-28	0.01441	1	0
TINAG	27283	broad.mit.edu	37	6	54191689	54191689	+	Missense_Mutation	SNP	T	T	A			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr6:54191689T>A	uc003pcj.2	+	4	745	c.599T>A	c.(598-600)ATG>AAG	p.M200K	TINAG_uc010jzt.2_RNA	NM_014464	NP_055279	Q9UJW2	TINAG_HUMAN	tubulointerstitial nephritis antigen	200					cell adhesion|immune response|Malpighian tubule morphogenesis|proteolysis	basement membrane	cysteine-type endopeptidase activity|nucleotide binding|polysaccharide binding|scavenger receptor activity			ovary(3)|central_nervous_system(1)	4	Lung NSC(77;0.0518)		LUSC - Lung squamous cell carcinoma(124;0.246)			CCTAGTCCCATGCTCCTGAGC	0.393			NA											39	67					0	0	0.009718	0	0
BAI3	577	broad.mit.edu	37	6	69348714	69348714	+	Silent	SNP	T	T	A			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr6:69348714T>A	uc003pev.3	+	3	595	c.147T>A	c.(145-147)CCT>CCA	p.P49P	BAI3_uc010kak.2_Silent_p.P49P	NM_001704	NP_001695	O60242	BAI3_HUMAN	brain-specific angiogenesis inhibitor 3	49	CUB.|Extracellular (Potential).				negative regulation of angiogenesis|neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			lung(27)|ovary(8)|skin(6)|pancreas(4)|central_nervous_system(3)|urinary_tract(1)|breast(1)	50		all_lung(197;0.212)				AAATGTTTCCTAAAAACTTTA	0.383			NA											53	63					0	0	0.01441	0	0
COL12A1	1303	broad.mit.edu	37	6	75844451	75844451	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr6:75844451C>A	uc003phs.2	-	32	5681	c.5515G>T	c.(5515-5517)GGC>TGC	p.G1839C	COL12A1_uc003pht.2_Missense_Mutation_p.G675C	NM_004370	NP_004361	Q99715	COCA1_HUMAN	collagen, type XII, alpha 1 long isoform	1839	Fibronectin type-III 13.				cell adhesion|collagen fibril organization|skeletal system development	collagen type XII|extracellular space	extracellular matrix structural constituent conferring tensile strength			ovary(6)|large_intestine(1)|breast(1)|skin(1)	9						CTGGTCTTGCCTCTTCCCGTC	0.453			NA											33	59					1.62565e-12	2.14003e-12	0.012213	1	0
MDN1	23195	broad.mit.edu	37	6	90503894	90503894	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr6:90503894C>G	uc003pnn.1	-	4	703	c.587G>C	c.(586-588)TGT>TCT	p.C196S	MDN1_uc003pnp.1_Missense_Mutation_p.C196S	NM_014611	NP_055426	Q9NU22	MDN1_HUMAN	MDN1, midasin homolog	196					protein complex assembly|regulation of protein complex assembly	nucleus	ATP binding|ATPase activity|unfolded protein binding			ovary(8)|skin(2)	10		all_cancers(76;1.47e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00246)		BRCA - Breast invasive adenocarcinoma(108;0.0193)		TTCATTCATACAGGTAACCAA	0.338			NA											23	44					0	0	0.00632	0	0
CASP8AP2	9994	broad.mit.edu	37	6	90576192	90576192	+	Silent	SNP	A	A	G			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr6:90576192A>G	uc003pnr.2	+	8	3379	c.3183A>G	c.(3181-3183)TCA>TCG	p.S1061S	CASP8AP2_uc003pns.2_Intron|CASP8AP2_uc003pnt.2_Silent_p.S1061S|CASP8AP2_uc011dzz.1_Silent_p.S1061S	NM_001137667	NP_001131139	Q9UKL3	C8AP2_HUMAN	caspase 8 associated protein 2	1061					cell cycle|cellular response to mechanical stimulus|induction of apoptosis via death domain receptors|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	cytoplasm|nucleus	caspase activator activity|death receptor binding|transcription corepressor activity			ovary(2)	2		all_cancers(76;3.64e-09)|Prostate(29;1.16e-10)|Acute lymphoblastic leukemia(125;1.45e-10)|all_hematologic(105;7.74e-07)|all_epithelial(107;4.69e-05)|Lung NSC(302;0.238)		BRCA - Breast invasive adenocarcinoma(108;0.0953)		CAAAATTTTCATTAATACAAT	0.289	Colon(187;1656 2025 17045 31481 39901)		NA											3	1					0	0	0.004672	0	0
POPDC3	64208	broad.mit.edu	37	6	105609367	105609367	+	Missense_Mutation	SNP	T	T	G			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr6:105609367T>G	uc003prb.2	-	2	820	c.418A>C	c.(418-420)AAG>CAG	p.K140Q	uc003pqz.2_Intron|POPDC3_uc003pra.2_Intron	NM_022361	NP_071756	Q9HBV1	POPD3_HUMAN	popeye protein 3	140						integral to membrane				skin(3)|ovary(2)	5		all_cancers(87;4.87e-05)|Acute lymphoblastic leukemia(125;1.9e-08)|all_hematologic(75;9.25e-07)|all_epithelial(87;0.0157)|Colorectal(196;0.202)|Lung NSC(302;0.238)				CAGTGTTCCTTTTCCAAAGTA	0.453			NA											54	145					0	0	0.01441	0	0
LAMA2	3908	broad.mit.edu	37	6	129649532	129649532	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr6:129649532G>T	uc003qbn.2	+	29	4391	c.4286G>T	c.(4285-4287)TGT>TTT	p.C1429F	LAMA2_uc003qbo.2_Missense_Mutation_p.C1429F	NM_000426	NP_000417	P24043	LAMA2_HUMAN	laminin alpha 2 subunit isoform a precursor	1429	Laminin EGF-like 15.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|breast(1)|skin(1)	10				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		AGCAGCCTGTGTGACCCTGAA	0.532			NA											61	125					1.02016e-41	1.71713e-41	0.01441	1	0
UTRN	7402	broad.mit.edu	37	6	144844318	144844318	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr6:144844318G>T	uc003qkt.2	+	40	5992	c.5900G>T	c.(5899-5901)CGG>CTG	p.R1967L		NM_007124	NP_009055	P46939	UTRO_HUMAN	utrophin	1967	Spectrin 13.				muscle contraction|muscle organ development|positive regulation of cell-matrix adhesion	cell junction|cytoplasm|cytoskeleton|membrane fraction|nucleus|postsynaptic membrane	actin binding|calcium ion binding|zinc ion binding			ovary(4)|pancreas(1)	5		Ovarian(120;0.218)		OV - Ovarian serous cystadenocarcinoma(155;5.72e-07)|GBM - Glioblastoma multiforme(68;4.9e-05)|Colorectal(48;0.213)		TACAGTGATCGGAAAGGGTAT	0.378			NA											23	32					4.26978e-12	5.57092e-12	0.00333	1	0
GRM1	2911	broad.mit.edu	37	6	146720730	146720730	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr6:146720730C>A	uc010khw.1	+	8	3025	c.2555C>A	c.(2554-2556)ACC>AAC	p.T852N	GRM1_uc010khv.1_Missense_Mutation_p.T852N|GRM1_uc003qll.2_Missense_Mutation_p.T852N|GRM1_uc011edz.1_Missense_Mutation_p.T852N|GRM1_uc011eea.1_Missense_Mutation_p.T852N	NM_000838	NP_000829	Q13255	GRM1_HUMAN	glutamate receptor, metabotropic 1 isoform alpha	852	Cytoplasmic (Potential).				synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			lung(8)|ovary(4)|central_nervous_system(3)|large_intestine(2)|breast(2)	19		Ovarian(120;0.0387)		OV - Ovarian serous cystadenocarcinoma(155;5.35e-08)|GBM - Glioblastoma multiforme(68;0.00762)	Acamprosate(DB00659)|L-Glutamic Acid(DB00142)	GCCTTCACCACCTCTGATGTT	0.532			NA											18	54					6.94344e-10	8.57719e-10	0.006122	1	0
PLG	5340	broad.mit.edu	37	6	161135878	161135878	+	Silent	SNP	C	C	A			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr6:161135878C>A	uc003qtm.3	+	6	663	c.600C>A	c.(598-600)ACC>ACA	p.T200T		NM_000301	NP_000292	P00747	PLMN_HUMAN	plasminogen	200	Kringle 2.				extracellular matrix disassembly|fibrinolysis|negative regulation of cell proliferation|negative regulation of cell-substrate adhesion|negative regulation of fibrinolysis|platelet activation|platelet degranulation|positive regulation of fibrinolysis|proteolysis|tissue remodeling	extracellular space|extrinsic to external side of plasma membrane|platelet alpha granule lumen	apolipoprotein binding|cell surface binding|serine-type endopeptidase activity			skin(3)|ovary(1)	4				OV - Ovarian serous cystadenocarcinoma(65;5.24e-17)|BRCA - Breast invasive adenocarcinoma(81;7.08e-06)	Aminocaproic Acid(DB00513)|Streptokinase(DB00086)|Tranexamic Acid(DB00302)|Urokinase(DB00013)	TTTCCAAGACCATGTCTGGAC	0.463			NA											26	45					1.06801e-11	1.38121e-11	0.009535	1	0
TTLL2	83887	broad.mit.edu	37	6	167753913	167753913	+	Nonsense_Mutation	SNP	C	C	A			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr6:167753913C>A	uc003qvs.1	+	3	613	c.525C>A	c.(523-525)TAC>TAA	p.Y175*	TTLL2_uc011egr.1_RNA	NM_031949	NP_114155	Q9BWV7	TTLL2_HUMAN	tubulin tyrosine ligase-like family, member 2	175	TTL.				protein modification process		ATP binding|tubulin-tyrosine ligase activity			ovary(1)|central_nervous_system(1)|skin(1)	3		Breast(66;7.8e-06)|Ovarian(120;0.024)		OV - Ovarian serous cystadenocarcinoma(33;2.22e-20)|BRCA - Breast invasive adenocarcinoma(81;6.17e-07)|GBM - Glioblastoma multiforme(31;0.00492)		CTTCCCTGTACCAGTTCATCC	0.507			NA											48	102					2.64894e-19	3.86816e-19	0.01441	1	0
THBS2	7058	broad.mit.edu	37	6	169648860	169648860	+	Silent	SNP	C	C	A			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr6:169648860C>A	uc003qwt.2	-	4	509	c.261G>T	c.(259-261)ACG>ACT	p.T87T		NM_003247	NP_003238	P35442	TSP2_HUMAN	thrombospondin 2 precursor	87	TSP N-terminal.|Heparin-binding (Potential).				cell adhesion	extracellular region	calcium ion binding|heparin binding|protein binding|structural molecule activity			ovary(5)	5		Breast(66;1.78e-05)|Ovarian(120;0.0728)|Esophageal squamous(34;0.247)		OV - Ovarian serous cystadenocarcinoma(33;1.85e-21)|BRCA - Breast invasive adenocarcinoma(81;1.43e-06)|GBM - Glioblastoma multiforme(31;0.000379)		TGAGCTGGGCCGTGAGGAAGA	0.617	Esophageal Squamous(91;219 1934 18562 44706)		NA											40	134					4.00102e-26	6.19105e-26	0.00623	1	0
ANLN	54443	broad.mit.edu	37	7	36483457	36483457	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr7:36483457G>A	uc003tff.2	+	22	3268	c.3064G>A	c.(3064-3066)GAT>AAT	p.D1022N	ANLN_uc011kaz.1_Missense_Mutation_p.D934N|ANLN_uc003tfg.2_Missense_Mutation_p.D985N|ANLN_uc010kxe.2_Missense_Mutation_p.D984N	NM_018685	NP_061155	Q9NQW6	ANLN_HUMAN	anillin, actin binding protein	1022	PH.|Localization to the cleavage furrow.				cytokinesis|mitosis|regulation of exit from mitosis|septin ring assembly	actomyosin contractile ring|nucleus	actin binding			ovary(2)|skin(1)	3						TTATCCAGATGATGAGAAACG	0.408			NA											11	13					0	0	0.010729	0	0
PCLO	27445	broad.mit.edu	37	7	82764745	82764745	+	Silent	SNP	C	C	T			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr7:82764745C>T	uc003uhx.2	-	3	2410	c.2121G>A	c.(2119-2121)GTG>GTA	p.V707V	PCLO_uc003uhv.2_Silent_p.V707V	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	653	Pro-rich.				cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						TTGGTTGTTTCACTAGTGGTG	0.542			NA											15	78					0	0	0.007413	0	0
C7orf64	84060	broad.mit.edu	37	7	92164123	92164123	+	Missense_Mutation	SNP	A	A	G			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr7:92164123A>G	uc003ulz.2	+	4	897	c.856A>G	c.(856-858)AGA>GGA	p.R286G	C7orf64_uc003uma.2_Missense_Mutation_p.R286G	NM_032120	NP_115496	Q5RL73	CG064_HUMAN	hypothetical protein LOC84060	286							nucleotide binding			ovary(2)	2						GGAGCGCAAAAGAAGAAGAGA	0.428			NA											15	19					0	0	0.004007	0	0
SERPINE1	5054	broad.mit.edu	37	7	100771819	100771819	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr7:100771819G>T	uc003uxt.2	+	2	293	c.145G>T	c.(145-147)GCC>TCC	p.A49S	SERPINE1_uc011kkj.1_Missense_Mutation_p.A34S|SERPINE1_uc003uxu.1_5'Flank	NM_000602	NP_000593	P05121	PAI1_HUMAN	plasminogen activator inhibitor-1 isoform 1	49					angiogenesis|cellular response to chemical stimulus|cellular response to lipopolysaccharide|chronological cell aging|defense response to Gram-negative bacterium|fibrinolysis|negative regulation of apoptosis|negative regulation of cell adhesion mediated by integrin|negative regulation of fibrinolysis|negative regulation of plasminogen activation|negative regulation of smooth muscle cell migration|negative regulation of smooth muscle cell-matrix adhesion|negative regulation of vascular wound healing|platelet activation|platelet degranulation|positive regulation of angiogenesis|positive regulation of interleukin-8 production|positive regulation of leukotriene production involved in inflammatory response|positive regulation of monocyte chemotaxis|positive regulation of receptor-mediated endocytosis|regulation of receptor activity	extracellular matrix|extracellular space|plasma membrane|platelet alpha granule lumen	protease binding|serine-type endopeptidase inhibitor activity			ovary(1)|lung(1)|central_nervous_system(1)	3	Lung NSC(181;0.136)|all_lung(186;0.182)				Atorvastatin(DB01076)|Dimethyl sulfoxide(DB01093)|Drotrecogin alfa(DB00055)|Simvastatin(DB00641)|Tenecteplase(DB00031)|Troglitazone(DB00197)|Urokinase(DB00013)	GGTGGCGCAGGCCTCCAAGGA	0.602			NA											31	49					2.08457e-15	2.85495e-15	0.010818	1	0
RELN	5649	broad.mit.edu	37	7	103126853	103126853	+	Nonsense_Mutation	SNP	G	G	T			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr7:103126853G>T	uc003vca.2	-	61	9934	c.9774C>A	c.(9772-9774)TGC>TGA	p.C3258*	RELN_uc010liz.2_Nonsense_Mutation_p.C3258*	NM_005045	NP_005036	P78509	RELN_HUMAN	reelin isoform a	3258	EGF-like 8.				axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			ovary(8)|upper_aerodigestive_tract(5)|large_intestine(2)|central_nervous_system(2)|skin(1)|pancreas(1)	19				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		TGAAAACAGAGCAGTCATCAC	0.423	NSCLC(146;835 1944 15585 22231 52158)		NA											41	35					3.54561e-26	5.50568e-26	0.009718	1	0
GPR22	2845	broad.mit.edu	37	7	107115753	107115753	+	Missense_Mutation	SNP	T	T	A			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr7:107115753T>A	uc003vef.2	+	3	2594	c.1248T>A	c.(1246-1248)TTT>TTA	p.F416L	COG5_uc003vec.2_Intron|COG5_uc003ved.2_Intron|COG5_uc003vee.2_Intron	NM_005295	NP_005286	Q99680	GPR22_HUMAN	G protein-coupled receptor 22	416	Cytoplasmic (Potential).					integral to plasma membrane	G-protein coupled receptor activity			ovary(2)	2						AAATTACCTTTGAAGATAGTG	0.338			NA											7	5					0	0	0.00308	0	0
PLXNA4	91584	broad.mit.edu	37	7	131888169	131888169	+	Nonsense_Mutation	SNP	C	C	A			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr7:131888169C>A	uc003vra.3	-	11	2537	c.2308G>T	c.(2308-2310)GAA>TAA	p.E770*		NM_020911	NP_065962	Q9HCM2	PLXA4_HUMAN	plexin A4 isoform 1	770	Extracellular (Potential).					integral to membrane|intracellular|plasma membrane				ovary(1)	1						TCCATCCCTTCATAGGAATAC	0.522			NA											4	138					0.00909568	0.0093939	0.009096	1	0
DENND2A	27147	broad.mit.edu	37	7	140301877	140301877	+	Silent	SNP	C	C	T			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr7:140301877C>T	uc010lnj.2	-	1	466	c.321G>A	c.(319-321)GAG>GAA	p.E107E	DENND2A_uc011kre.1_RNA|DENND2A_uc010lnk.2_Silent_p.E107E|DENND2A_uc003vvw.2_Silent_p.E107E|DENND2A_uc003vvx.2_Silent_p.E107E	NM_015689	NP_056504	Q9ULE3	DEN2A_HUMAN	DENN/MADD domain containing 2A	107										ovary(3)|breast(1)	4	Melanoma(164;0.00956)					TCCTCTCCTTCTCTGTGCTCT	0.577			NA											157	153					0	0	0.01441	0	0
BRAF	673	broad.mit.edu	37	7	140434413	140434413	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr7:140434413G>T	uc003vwc.3	-	18	2346	c.2285C>A	c.(2284-2286)GCG>GAG	p.A762E		NM_004333	NP_004324	P15056	BRAF_HUMAN	B-Raf	762					activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding		KIAA1549/BRAF(229)|AKAP9_ENST00000356239/BRAF(10)|AGTRAP/BRAF(2)|FCHSD1/BRAF(2)|SLC45A3/BRAF(2)	thyroid(8166)|large_intestine(5052)|skin(3798)|NS(368)|central_nervous_system(284)|ovary(236)|lung(78)|eye(53)|prostate(44)|endometrium(30)|biliary_tract(28)|soft_tissue(27)|haematopoietic_and_lymphoid_tissue(22)|breast(18)|upper_aerodigestive_tract(13)|stomach(13)|pancreas(10)|small_intestine(10)|testis(7)|bone(6)|cervix(5)|genital_tract(4)|oesophagus(3)|urinary_tract(3)|adrenal_gland(3)|gastrointestinal_tract_(site_indeterminate)(2)|liver(2)|meninges(1)|kidney(1)|autonomic_ganglia(1)|pituitary(1)|salivary_gland(1)	18290	Melanoma(164;0.00956)				Sorafenib(DB00398)	GACAGGAAACGCACCATATCC	0.403	Colon(40;35 892 2973 5743 27438)		61	Mis|T|O	AKAP9|KIAA1549	melanoma|colorectal|papillary thyroid|borderline ov|Non small-cell lung cancer (NSCLC)|cholangiocarcinoma|pilocytic astrocytoma		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous_syndrome				183	189					2.13639e-87	3.75358e-87	0.01441	1	0
GIMAP2	26157	broad.mit.edu	37	7	150389570	150389570	+	Nonsense_Mutation	SNP	G	G	T			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr7:150389570G>T	uc003who.2	+	3	284	c.196G>T	c.(196-198)GGA>TGA	p.G66*	GIMAP1_uc003whp.2_Intron	NM_015660	NP_056475	Q9UG22	GIMA2_HUMAN	GTPase, IMAP family member 2	66						integral to membrane	GTP binding			skin(1)	1			OV - Ovarian serous cystadenocarcinoma(82;0.0145)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		CAAAAGTCAGGGAAGCTGGGG	0.368			NA											44	21					6.21074e-16	8.58601e-16	0.011902	1	0
MLL3	58508	broad.mit.edu	37	7	151962157	151962157	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr7:151962157G>C	uc003wla.2	-	8	1369	c.1150C>G	c.(1150-1152)CAA>GAA	p.Q384E		NM_170606	NP_733751	Q8NEZ4	MLL3_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 3	384	PHD-type 1.|RING-type.				intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			large_intestine(27)|pancreas(13)|ovary(9)|central_nervous_system(8)|breast(3)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	63	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)		TCAGGACATTGCCAACCTGCA	0.428	Colon(68;14 1149 1884 27689 34759)		NA	N		medulloblastoma								18	288					0	0	0.00632	0	0
PTPRN2	5799	broad.mit.edu	37	7	157414082	157414082	+	Silent	SNP	G	G	T			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr7:157414082G>T	uc003wno.2	-	15	2437	c.2316C>A	c.(2314-2316)CCC>CCA	p.P772P	PTPRN2_uc003wnp.2_Silent_p.P755P|PTPRN2_uc003wnq.2_Silent_p.P743P|PTPRN2_uc003wnr.2_Silent_p.P734P|PTPRN2_uc011kwa.1_Silent_p.P795P	NM_002847	NP_002838	Q92932	PTPR2_HUMAN	protein tyrosine phosphatase, receptor type, N	772	Cytoplasmic (Potential).|Tyrosine-protein phosphatase.					integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			ovary(4)|large_intestine(1)|pleura(1)|skin(1)	7	all_neural(206;0.181)	all_cancers(7;8.99e-13)|all_epithelial(9;2.4e-06)|all_hematologic(28;0.0155)|Breast(660;0.132)	OV - Ovarian serous cystadenocarcinoma(82;0.00463)	STAD - Stomach adenocarcinoma(7;0.0875)		AGCGGTTCTTGGGCACGTTCT	0.637			NA											8	537					1.58986e-06	1.79317e-06	0.008291	1	0
DLGAP2	9228	broad.mit.edu	37	8	1497520	1497520	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr8:1497520G>T	uc003wpl.2	+	2	758	c.661G>T	c.(661-663)GAC>TAC	p.D221Y	DLGAP2_uc003wpm.2_Missense_Mutation_p.D221Y	NM_004745	NP_004736	Q9P1A6	DLGP2_HUMAN	discs large-associated protein 2	300					neuron-neuron synaptic transmission	cell junction|neurofilament|postsynaptic density|postsynaptic membrane	protein binding				0		Ovarian(12;0.0271)|Hepatocellular(245;0.0838)|Colorectal(14;0.0846)		BRCA - Breast invasive adenocarcinoma(11;0.000169)|READ - Rectum adenocarcinoma(644;0.171)		GAGCTCGGACGACAACCTGGA	0.697			NA											36	68					6.68952e-21	9.93292e-21	0.013114	1	0
RP1L1	94137	broad.mit.edu	37	8	10470214	10470214	+	Nonsense_Mutation	SNP	G	G	T			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr8:10470214G>T	uc003wtc.2	-	4	1623	c.1394C>A	c.(1393-1395)TCG>TAG	p.S465*		NM_178857	NP_849188	Q8IWN7	RP1L1_HUMAN	retinitis pigmentosa 1-like 1	465					intracellular signal transduction					ovary(4)|breast(3)|central_nervous_system(1)	8				COAD - Colon adenocarcinoma(149;0.0811)		CTCTGGCTCCGAGCCCTCGGG	0.716			NA											13	67					8.10497e-08	9.53145e-08	0.010504	1	0
C8orf74	203076	broad.mit.edu	37	8	10555360	10555360	+	Nonsense_Mutation	SNP	G	G	T			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr8:10555360G>T	uc003wtd.1	+	3	522	c.493G>T	c.(493-495)GAG>TAG	p.E165*	C8orf74_uc003wte.1_RNA	NM_001040032	NP_001035121	Q6P047	CH074_HUMAN	hypothetical protein LOC203076	165											0				COAD - Colon adenocarcinoma(149;0.0811)		GTGGATCCACGAGCAGCAGGT	0.677			NA											26	45					3.1745e-13	4.22946e-13	0.008361	1	0
TEX15	56154	broad.mit.edu	37	8	30704102	30704102	+	Missense_Mutation	SNP	T	T	A			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr8:30704102T>A	uc003xil.2	-	1	2432	c.2432A>T	c.(2431-2433)AAT>ATT	p.N811I		NM_031271	NP_112561	Q9BXT5	TEX15_HUMAN	testis expressed 15	811										ovary(3)|upper_aerodigestive_tract(2)|skin(2)	7				KIRC - Kidney renal clear cell carcinoma(542;0.0918)|Kidney(114;0.111)		ATCTTCCTTATTTATTTCCGG	0.368			NA											4	25					0	0	0.004482	0	0
ADAM9	8754	broad.mit.edu	37	8	38884248	38884248	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr8:38884248G>T	uc003xmr.2	+	11	1127	c.1049G>T	c.(1048-1050)GGT>GTT	p.G350V	ADAM9_uc011lcf.1_RNA|ADAM9_uc011lcg.1_RNA|ADAM9_uc010lwr.2_RNA	NM_003816	NP_003807	Q13443	ADAM9_HUMAN	ADAM metallopeptidase domain 9 isoform 1	350	Extracellular (Potential).|Peptidase M12B.				activation of MAPKK activity|cell-cell adhesion mediated by integrin|cell-matrix adhesion|keratinocyte differentiation|monocyte activation|PMA-inducible membrane protein ectodomain proteolysis|PMA-inducible membrane protein ectodomain proteolysis|positive regulation of cell adhesion mediated by integrin|positive regulation of keratinocyte migration|positive regulation of macrophage fusion|positive regulation of membrane protein ectodomain proteolysis|positive regulation of protein secretion|response to calcium ion|response to glucocorticoid stimulus|response to hydrogen peroxide|response to manganese ion|response to tumor necrosis factor|transforming growth factor beta receptor signaling pathway	extracellular space|extracellular space|integral to membrane|intrinsic to external side of plasma membrane	collagen binding|integrin binding|laminin binding|metalloendopeptidase activity|protein kinase C binding|SH3 domain binding|zinc ion binding			ovary(1)|central_nervous_system(1)	2		all_lung(54;0.00292)|Lung NSC(58;0.0115)|Hepatocellular(245;0.0153)	LUSC - Lung squamous cell carcinoma(45;2.74e-07)			CATGAATTGGGTCATAATCTT	0.423			NA											49	102					3.76525e-18	5.35637e-18	0.01441	1	0
ADAM2	2515	broad.mit.edu	37	8	39624713	39624713	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr8:39624713C>A	uc003xnj.2	-	13	1345	c.1270G>T	c.(1270-1272)GGT>TGT	p.G424C	ADAM2_uc003xnk.2_Missense_Mutation_p.G405C|ADAM2_uc011lck.1_Missense_Mutation_p.G424C|ADAM2_uc003xnl.2_Missense_Mutation_p.G298C	NM_001464	NP_001455	Q99965	ADAM2_HUMAN	ADAM metallopeptidase domain 2 proprotein	424	Extracellular (Potential).|Disintegrin.				cell adhesion|fusion of sperm to egg plasma membrane|proteolysis	integral to plasma membrane	integrin binding|metalloendopeptidase activity|zinc ion binding			ovary(1)|lung(1)	2		all_cancers(7;2.38e-28)|all_epithelial(6;8.85e-21)|all_lung(54;1.24e-07)|Lung NSC(58;1.94e-07)|Hepatocellular(245;0.00745)|Breast(189;0.00908)|Renal(179;0.0183)|Colorectal(162;0.246)	LUSC - Lung squamous cell carcinoma(45;0.000149)	READ - Rectum adenocarcinoma(644;0.0689)|Kidney(114;0.162)		CAGTTTGAACCGGCTTTAAAT	0.358			NA											65	161					5.96624e-29	9.53302e-29	0.01441	1	0
TRPA1	8989	broad.mit.edu	37	8	72984007	72984007	+	Nonsense_Mutation	SNP	A	A	T			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr8:72984007A>T	uc003xza.2	-	2	382	c.207T>A	c.(205-207)TAT>TAA	p.Y69*		NM_007332	NP_015628	O75762	TRPA1_HUMAN	ankyrin-like protein 1	69	Cytoplasmic (Potential).|ANK 1.					integral to plasma membrane				ovary(4)|lung(1)|kidney(1)	6			Epithelial(68;0.223)		Menthol(DB00825)	CTGCTGCAGCATAATGCAAGA	0.353			NA											8	28					0	0	0.004482	0	0
FAM82B	51115	broad.mit.edu	37	8	87498776	87498776	+	Nonsense_Mutation	SNP	A	A	T	rs144513651		TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr8:87498776A>T	uc003ydu.2	-	4	592	c.432T>A	c.(430-432)TAT>TAA	p.Y144*	FAM82B_uc011lfz.1_Nonsense_Mutation_p.Y144*|FAM82B_uc011lga.1_Nonsense_Mutation_p.Y144*	NM_016033	NP_057117	Q96DB5	RMD1_HUMAN	regulator of microtubule dynamics 1	144						microtubule|spindle pole	binding			ovary(1)	1						CTAGGGCTTCATACACCAATA	0.413			NA											27	36					0	0	0.008361	0	0
PGCP	10404	broad.mit.edu	37	8	97797349	97797349	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr8:97797349G>T	uc003yhw.2	+	2	390	c.224G>T	c.(223-225)GGA>GTA	p.G75V	PGCP_uc010mbe.2_Missense_Mutation_p.G75V	NM_016134	NP_057218	Q9Y646	PGCP_HUMAN	plasma glutamate carboxypeptidase precursor	75					peptide metabolic process|proteolysis	cytoplasm|extracellular space	metal ion binding|metallocarboxypeptidase activity			upper_aerodigestive_tract(1)	1	Breast(36;1.86e-05)					GATACTGTTGGACCCAGACTG	0.468			NA											12	64					2.27111e-07	2.62188e-07	0.013537	1	0
NIPAL2	79815	broad.mit.edu	37	8	99264759	99264759	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr8:99264759C>A	uc003yil.1	-	3	564	c.308G>T	c.(307-309)GGG>GTG	p.G103V	NIPAL2_uc011lgw.1_5'Flank|NIPAL2_uc003yim.1_Missense_Mutation_p.G103V	NM_024759	NP_079035	Q9H841	NPAL2_HUMAN	NIPA-like domain containing 2	103	Helical; (Potential).					integral to membrane					0						TGCAAAGTTCCCCGTCTCTCC	0.502			NA											6	34					1.12685e-05	1.24547e-05	0.004482	1	0
RIMS2	9699	broad.mit.edu	37	8	104955095	104955095	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr8:104955095C>A	uc003yls.2	+	12	2217	c.1976C>A	c.(1975-1977)CCT>CAT	p.P659H	RIMS2_uc003ylp.2_Missense_Mutation_p.P881H|RIMS2_uc003ylw.2_Missense_Mutation_p.P673H|RIMS2_uc003ylq.2_Missense_Mutation_p.P673H|RIMS2_uc003ylr.2_Missense_Mutation_p.P720H|RIMS2_uc003ylt.2_Missense_Mutation_p.P266H	NM_014677	NP_055492	Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	943					intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			ovary(6)|lung(2)|breast(2)|skin(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	15			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			CTTCCCCACCCTTCTCCATAT	0.373			NA								HNSCC(12;0.0054)			19	20					2.21704e-12	2.90986e-12	0.00278	1	0
ANGPT1	284	broad.mit.edu	37	8	108264099	108264099	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr8:108264099C>T	uc003ymn.2	-	9	1949	c.1481G>A	c.(1480-1482)CGA>CAA	p.R494Q	ANGPT1_uc011lhv.1_Missense_Mutation_p.R294Q|ANGPT1_uc003ymo.2_Missense_Mutation_p.R493Q	NM_001146	NP_001137	Q15389	ANGP1_HUMAN	angiopoietin 1 precursor	494	Fibrinogen C-terminal.				activation of transmembrane receptor protein tyrosine kinase activity|anti-apoptosis|blood coagulation|cell differentiation|heparin biosynthetic process|leukocyte migration|negative regulation of cell adhesion|negative regulation of endothelial cell apoptosis|negative regulation of vascular permeability|positive chemotaxis|positive regulation of blood vessel endothelial cell migration|positive regulation of ERK1 and ERK2 cascade|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of protein kinase B signaling cascade|positive regulation of protein ubiquitination|positive regulation of receptor internalization|protein localization at cell surface|regulation of satellite cell proliferation|sprouting angiogenesis|Tie receptor signaling pathway	extracellular space|membrane raft|microvillus|plasma membrane	receptor tyrosine kinase binding			ovary(3)|skin(3)|upper_aerodigestive_tract(1)	7	Breast(1;5.06e-08)		OV - Ovarian serous cystadenocarcinoma(57;5.53e-09)			ATCTAAAGGTCGAATCATCAT	0.413			NA											14	79					0	0	0.00245	0	0
CSMD3	114788	broad.mit.edu	37	8	113314033	113314033	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr8:113314033G>T	uc003ynu.2	-	53	8588	c.8429C>A	c.(8428-8430)ACC>AAC	p.T2810N	CSMD3_uc003yns.2_Missense_Mutation_p.T2012N|CSMD3_uc003ynt.2_Missense_Mutation_p.T2770N|CSMD3_uc011lhx.1_Missense_Mutation_p.T2641N	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	2810	Extracellular (Potential).|Sushi 17.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						TAGGCATCTGGTTTCAGATTC	0.438			NA								HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			13	42					1.49906e-05	1.64859e-05	0.00245	1	0
CSMD3	114788	broad.mit.edu	37	8	113702259	113702259	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr8:113702259C>G	uc003ynu.2	-	14	2152	c.1993G>C	c.(1993-1995)GGT>CGT	p.G665R	CSMD3_uc003yns.2_5'UTR|CSMD3_uc003ynt.2_Missense_Mutation_p.G625R|CSMD3_uc011lhx.1_Missense_Mutation_p.G561R	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	665	Extracellular (Potential).|Sushi 3.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						CCAGGATCACCACAACTTTCT	0.363			NA								HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			40	60					0	0	0.006999	0	0
CSMD3	114788	broad.mit.edu	37	8	113988072	113988072	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr8:113988072G>T	uc003ynu.2	-	7	1495	c.1336C>A	c.(1336-1338)CAT>AAT	p.H446N	CSMD3_uc003ynt.2_Missense_Mutation_p.H406N|CSMD3_uc011lhx.1_Intron	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	446	Extracellular (Potential).					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						ATACCTCTATGAGTAACAACT	0.403			NA								HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			23	43					3.28513e-13	4.36368e-13	0.003954	1	0
RAD21	5885	broad.mit.edu	37	8	117868465	117868465	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr8:117868465G>C	uc003yod.2	-	8	1165	c.877C>G	c.(877-879)CAA>GAA	p.Q293E		NM_006265	NP_006256	O60216	RAD21_HUMAN	RAD21 homolog	293	Interaction with WAPAL and PDS5B.				apoptosis|cell division|chromosome segregation|double-strand break repair|mitotic metaphase/anaphase transition|mitotic prometaphase|protein localization to chromatin|reciprocal meiotic recombination|regulation of transcription from RNA polymerase II promoter	chromosome, centromeric region|cohesin complex|nuclear chromosome|nucleoplasm	protein binding			lung(1)|skin(1)	2	all_cancers(13;1.21e-21)|Lung NSC(37;0.000134)|Ovarian(258;0.0172)					AGTGTTGTTTGATCAGTCATG	0.363			NA											3	73					0	0	0.004672	0	0
NOV	4856	broad.mit.edu	37	8	120431528	120431528	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr8:120431528G>T	uc003yoq.2	+	4	941	c.720G>T	c.(718-720)CAG>CAT	p.Q240H		NM_002514	NP_002505	P48745	NOV_HUMAN	nephroblastoma overexpressed precursor	240	TSP type-1.				regulation of cell growth		growth factor activity|insulin-like growth factor binding			ovary(2)|skin(2)|kidney(1)	5	all_cancers(13;3.84e-26)|Lung NSC(37;1.19e-08)|Ovarian(258;0.0249)|Hepatocellular(40;0.161)		STAD - Stomach adenocarcinoma(47;0.000507)		Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	TGCTGAAACAGACTCGGCTCT	0.547			NA											51	151					1.27334e-21	1.90353e-21	0.01441	1	0
SMARCA2	6595	broad.mit.edu	37	9	2101582	2101582	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr9:2101582G>C	uc003zhc.2	+	22	3190	c.3091G>C	c.(3091-3093)GAA>CAA	p.E1031Q	SMARCA2_uc003zhd.2_Missense_Mutation_p.E1031Q|SMARCA2_uc010mha.2_Missense_Mutation_p.E964Q	NM_003070	NP_003061	P51531	SMCA2_HUMAN	SWI/SNF-related matrix-associated	1031					chromatin remodeling|negative regulation of cell growth|negative regulation of transcription from RNA polymerase II promoter|nervous system development	intermediate filament cytoskeleton|nBAF complex|npBAF complex|nuclear chromatin|nucleoplasm|SWI/SNF complex|WINAC complex	ATP binding|DNA-dependent ATPase activity|helicase activity|protein binding|RNA polymerase II transcription coactivator activity|transcription regulatory region DNA binding			ovary(2)|central_nervous_system(1)	3		all_lung(10;2.06e-09)|Lung NSC(10;2.43e-09)		GBM - Glioblastoma multiforme(50;0.0475)		ATCCTTTGCTGAACACCTAGG	0.299			NA											5	28					0	0	0.001984	0	0
RFX3	5991	broad.mit.edu	37	9	3263012	3263012	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr9:3263012G>C	uc003zhr.2	-	14	1840	c.1528C>G	c.(1528-1530)CGT>GGT	p.R510G	RFX3_uc010mhd.2_Missense_Mutation_p.R510G|RFX3_uc003zhs.1_Missense_Mutation_p.R510G	NM_134428	NP_602304	P48380	RFX3_HUMAN	regulatory factor X3 isoform b	510					cell maturation|ciliary cell motility|cilium assembly|cilium movement involved in determination of left/right asymmetry|endocrine pancreas development|negative regulation of transcription, DNA-dependent|positive regulation of transcription from RNA polymerase II promoter|positive regulation of type B pancreatic cell development|regulation of insulin secretion	nuclear chromatin	protein binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding			ovary(2)|central_nervous_system(1)|pancreas(1)	4				GBM - Glioblastoma multiforme(50;0.00124)|Lung(2;0.0337)		AGCACTGCACGAGCTGCCTGG	0.493			NA											38	61					0	0	0.006999	0	0
PTPRD	5789	broad.mit.edu	37	9	8484300	8484300	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr9:8484300C>G	uc003zkk.2	-	29	3943	c.3232G>C	c.(3232-3234)GAG>CAG	p.E1078Q	PTPRD_uc003zkp.2_Missense_Mutation_p.E667Q|PTPRD_uc003zkq.2_Missense_Mutation_p.E667Q|PTPRD_uc003zkr.2_Missense_Mutation_p.E662Q|PTPRD_uc003zks.2_Missense_Mutation_p.E657Q|PTPRD_uc003zkl.2_Missense_Mutation_p.E1069Q|PTPRD_uc003zkm.2_Missense_Mutation_p.E1065Q|PTPRD_uc003zkn.2_Missense_Mutation_p.E667Q|PTPRD_uc003zko.2_Missense_Mutation_p.E664Q	NM_002839	NP_002830	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	1078	Fibronectin type-III 8.|Extracellular (Potential).				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			lung(14)|large_intestine(3)|ovary(2)|breast(2)|urinary_tract(1)	22		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		TATGATTTCTCAGGCTTCAGG	0.428			NA								TSP Lung(15;0.13)			3	65					0	0	0.004672	0	0
MPDZ	8777	broad.mit.edu	37	9	13188859	13188859	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr9:13188859C>A	uc010mia.1	-	16	2345	c.2288G>T	c.(2287-2289)AGT>ATT	p.S763I	MPDZ_uc010mhy.2_Missense_Mutation_p.S763I|MPDZ_uc010mhz.2_Missense_Mutation_p.S763I|MPDZ_uc011lmn.1_Missense_Mutation_p.S763I|MPDZ_uc003zlb.3_Missense_Mutation_p.S763I	NM_003829	NP_003820	O75970	MPDZ_HUMAN	multiple PDZ domain protein	763	PDZ 5.				interspecies interaction between organisms	apical plasma membrane|dendrite|postsynaptic density|postsynaptic membrane|synaptosome|tight junction	protein C-terminus binding			ovary(5)|central_nervous_system(1)	6				GBM - Glioblastoma multiforme(50;2.03e-06)		TTCCTCAAGACTGCTGTTTTC	0.463			NA											67	205					1.31311e-47	2.2445e-47	0.01441	1	0
C9orf93	203238	broad.mit.edu	37	9	15784550	15784550	+	Missense_Mutation	SNP	T	T	G			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr9:15784550T>G	uc003zmd.2	+	21	3440	c.3125T>G	c.(3124-3126)CTA>CGA	p.L1042R	C9orf93_uc003zme.2_Missense_Mutation_p.L957R|C9orf93_uc011lmu.1_Missense_Mutation_p.L1050R|C9orf93_uc003zmf.1_Missense_Mutation_p.L350R	NM_173550	NP_775821	Q6TFL3	CI093_HUMAN	hypothetical protein LOC203238	1042	Potential.										0				GBM - Glioblastoma multiforme(50;4.84e-07)		TGTGAAGAACTAAATAATGCA	0.373			NA											5	22					0	0	0.000602	0	0
BNC2	54796	broad.mit.edu	37	9	16436214	16436214	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr9:16436214G>T	uc003zml.2	-	6	2118	c.1978C>A	c.(1978-1980)CCC>ACC	p.P660T	BNC2_uc011lmw.1_Missense_Mutation_p.P565T|BNC2_uc003zmm.2_Missense_Mutation_p.P618T|BNC2_uc003zmq.1_Missense_Mutation_p.P674T|BNC2_uc003zmr.1_Missense_Mutation_p.P697T|BNC2_uc003zmp.1_Missense_Mutation_p.P688T|BNC2_uc010mij.1_Missense_Mutation_p.P582T|BNC2_uc011lmv.1_Missense_Mutation_p.P486T|BNC2_uc003zmo.1_Missense_Mutation_p.P582T|BNC2_uc003zmj.2_Missense_Mutation_p.P425T|BNC2_uc003zmk.2_RNA|BNC2_uc003zmi.2_Missense_Mutation_p.P425T|BNC2_uc003zmn.1_Missense_Mutation_p.P425T	NM_017637	NP_060107	Q6ZN30	BNC2_HUMAN	basonuclin 2	660					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	zinc ion binding			ovary(2)|central_nervous_system(1)	3				GBM - Glioblastoma multiforme(50;9.01e-08)		CCATCATTGGGGTCATCATCT	0.468			NA											11	76					0.00010058	0.000108185	0.013537	1	0
ARID3C	138715	broad.mit.edu	37	9	34627853	34627853	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr9:34627853C>A	uc011lon.1	-	1	159	c.159G>T	c.(157-159)GAG>GAT	p.E53D		NM_001017363	NP_001017363	A6NKF2	ARI3C_HUMAN	AT rich interactive domain 3C (BRIGHT- like)	53	Glu-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(1)	1	all_epithelial(49;0.102)		STAD - Stomach adenocarcinoma(86;0.178)	GBM - Glioblastoma multiforme(74;0.175)		cagcatcttcctcttcctcAG	0.458			NA											9	9					0.00621372	0.00649348	0.006214	1	0
LOC442421	442421	broad.mit.edu	37	9	66499680	66499680	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr9:66499680C>A	uc004aee.1	+	1	490	c.490C>A	c.(490-492)CCC>ACC	p.P164T	LOC442421_uc004aed.1_RNA					Homo sapiens hypothetical LOC442421, mRNA (cDNA clone IMAGE:40031134).												0						TCATGTTAACCCCTTCCCAGG	0.582			NA											11	65					6.40141e-05	6.93617e-05	0.010729	1	0
TRPM3	80036	broad.mit.edu	37	9	73151524	73151524	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr9:73151524G>T	uc004aid.2	-	25	4713	c.4469C>A	c.(4468-4470)CCT>CAT	p.P1490H	TRPM3_uc004ahu.2_Missense_Mutation_p.P1332H|TRPM3_uc004ahv.2_Missense_Mutation_p.P1292H|TRPM3_uc004ahw.2_Missense_Mutation_p.P1362H|TRPM3_uc004ahx.2_Missense_Mutation_p.P1349H|TRPM3_uc004ahy.2_Missense_Mutation_p.P1352H|TRPM3_uc004ahz.2_Missense_Mutation_p.P1339H|TRPM3_uc004aia.2_Missense_Mutation_p.P1337H|TRPM3_uc004aib.2_Missense_Mutation_p.P1327H|TRPM3_uc004aic.2_Intron	NM_001007471	NP_001007472	Q9HCF6	TRPM3_HUMAN	transient receptor potential cation channel,	1515	Cytoplasmic (Potential).					integral to membrane	calcium channel activity			ovary(3)|pancreas(2)|central_nervous_system(2)|skin(2)	9						GTACATCGGAGGCTCTGAGTC	0.493			NA											40	64					8.01111e-26	1.23528e-25	0.010771	1	0
TRPM3	80036	broad.mit.edu	37	9	73218374	73218374	+	Nonsense_Mutation	SNP	C	C	A			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr9:73218374C>A	uc004aid.2	-	19	2888	c.2644G>T	c.(2644-2646)GGA>TGA	p.G882*	TRPM3_uc004ahu.2_Nonsense_Mutation_p.G712*|TRPM3_uc004ahv.2_Nonsense_Mutation_p.G684*|TRPM3_uc004ahw.2_Nonsense_Mutation_p.G754*|TRPM3_uc004ahx.2_Nonsense_Mutation_p.G741*|TRPM3_uc004ahy.2_Nonsense_Mutation_p.G744*|TRPM3_uc004ahz.2_Nonsense_Mutation_p.G731*|TRPM3_uc004aia.2_Nonsense_Mutation_p.G729*|TRPM3_uc004aib.2_Nonsense_Mutation_p.G719*|TRPM3_uc004aic.2_Nonsense_Mutation_p.G882*	NM_001007471	NP_001007472	Q9HCF6	TRPM3_HUMAN	transient receptor potential cation channel,	907	Helical; (Potential).					integral to membrane	calcium channel activity			ovary(3)|pancreas(2)|central_nervous_system(2)|skin(2)	9						ATCAGGTATCCGATATACGCC	0.522			NA											26	38					3.73148e-12	4.88303e-12	0.007291	1	0
TMEM2	23670	broad.mit.edu	37	9	74313084	74313084	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr9:74313084C>A	uc011lsa.1	-	20	3954	c.3414G>T	c.(3412-3414)AGG>AGT	p.R1138S	TMEM2_uc011lrz.1_Missense_Mutation_p.R131S|TMEM2_uc010mos.2_Missense_Mutation_p.R1075S|TMEM2_uc011lsb.1_RNA|TMEM2_uc004aik.2_5'UTR	NM_013390	NP_037522	Q9UHN6	TMEM2_HUMAN	transmembrane protein 2 isoform a	1138						integral to membrane				ovary(2)	2		all_epithelial(88;4.56e-14)|Myeloproliferative disorder(762;0.0255)		GBM - Glioblastoma multiforme(74;7.45e-21)|OV - Ovarian serous cystadenocarcinoma(323;1.02e-16)		TGTGGCCATGCCTGTGGCTTT	0.418			NA											56	94					1.64573e-32	2.66827e-32	0.01441	1	0
GCNT1	2650	broad.mit.edu	37	9	79118029	79118029	+	Silent	SNP	G	G	T			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr9:79118029G>T	uc010mpf.2	+	3	1073	c.732G>T	c.(730-732)ACG>ACT	p.T244T	GCNT1_uc010mpg.2_Silent_p.T244T|GCNT1_uc010mph.2_Silent_p.T244T|GCNT1_uc004akf.3_Silent_p.T244T|GCNT1_uc010mpi.2_Silent_p.T244T|GCNT1_uc004akh.3_Silent_p.T244T	NM_001490	NP_001481	Q02742	GCNT1_HUMAN	beta-1,3-galactosyl-O-glycosyl-glycoprotein	244	Lumenal (Potential).|Catalytic (By similarity).				protein O-linked glycosylation	Golgi membrane|integral to membrane	beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity				0						ACCTGGAAACGGAGAGGATGC	0.418			NA											11	76					1.08611e-07	1.26713e-07	0.010729	1	0
HNRNPK	3190	broad.mit.edu	37	9	86593299	86593299	+	Translation_Start_Site	SNP	T	T	C			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr9:86593299T>C	uc004ang.3	-	2	186	c.-38A>G	c.(-40--36)ATATA>ATGTA		HNRNPK_uc011lsw.1_5'Flank|HNRNPK_uc004and.3_5'Flank|HNRNPK_uc004ank.3_Translation_Start_Site|HNRNPK_uc004anf.3_Translation_Start_Site|HNRNPK_uc004anh.3_Translation_Start_Site|HNRNPK_uc011lsx.1_Translation_Start_Site|HNRNPK_uc004ani.3_Translation_Start_Site|HNRNPK_uc004anj.3_Translation_Start_Site|HNRNPK_uc004ann.3_Translation_Start_Site|HNRNPK_uc004anl.3_Translation_Start_Site|HNRNPK_uc004anm.3_Translation_Start_Site|RMI1_uc004anq.3_5'Flank|RMI1_uc004anr.3_5'Flank|RMI1_uc004anp.3_5'Flank	NM_031262	NP_112552	P61978	HNRPK_HUMAN	heterogeneous nuclear ribonucleoprotein K						interspecies interaction between organisms|positive regulation of low-density lipoprotein particle receptor biosynthetic process|positive regulation of receptor-mediated endocytosis|regulation of lipid transport by positive regulation of transcription from an RNA polymerase II promoter|regulation of low-density lipoprotein particle clearance|signal transduction	catalytic step 2 spliceosome|cytoplasm|heterogeneous nuclear ribonucleoprotein complex|nuclear chromatin|nucleoplasm	protein binding|RNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|single-stranded DNA binding			skin(1)	1						AGTTATTATATATCCTTGCAG	0.383			NA											6	10					0	0	0.00308	0	0
MURC	347273	broad.mit.edu	37	9	103348672	103348672	+	Missense_Mutation	SNP	A	A	T			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr9:103348672A>T	uc004bba.2	+	2	1124	c.1034A>T	c.(1033-1035)AAA>ATA	p.K345I		NM_001018116	NP_001018126	Q5BKX8	MURC_HUMAN	muscle-related coiled-coil protein	345					cell differentiation|muscle organ development|transcription, DNA-dependent					ovary(1)	1		Acute lymphoblastic leukemia(62;0.0461)				GTTACTTTTAAATCTCAGGTG	0.423			NA											41	50					0	0	0.011902	0	0
ALDOB	229	broad.mit.edu	37	9	104189921	104189921	+	Missense_Mutation	SNP	A	A	T			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr9:104189921A>T	uc004bbk.2	-	5	465	c.383T>A	c.(382-384)CTT>CAT	p.L128H		NM_000035	NP_000026	P05062	ALDOB_HUMAN	aldolase B, fructose-bisphosphate	128					fructose 1,6-bisphosphate metabolic process|fructose catabolic process|gluconeogenesis|glycolysis|NADH oxidation|positive regulation of ATPase activity|vacuolar proton-transporting V-type ATPase complex assembly	centriolar satellite|cytosol	ATPase binding|cytoskeletal protein binding|fructose binding|fructose-bisphosphate aldolase activity|identical protein binding			skin(1)	1		Acute lymphoblastic leukemia(62;0.0559)				GAGGCCATCAAGCCCTGCAAG	0.498			NA											12	54					0	0	0.00245	0	0
OR13C2	392376	broad.mit.edu	37	9	107367202	107367202	+	Missense_Mutation	SNP	T	T	A			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr9:107367202T>A	uc011lvq.1	-	1	707	c.707A>T	c.(706-708)AAA>ATA	p.K236I		NM_001004481	NP_001004481	Q8NGS9	O13C2_HUMAN	olfactory receptor, family 13, subfamily C,	236	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						AGAGGAAGCTTTGCTTCTCCC	0.393			NA											31	55					0	0	0.013726	0	0
ZNF483	158399	broad.mit.edu	37	9	114305028	114305028	+	Missense_Mutation	SNP	A	A	G			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr9:114305028A>G	uc004bff.2	+	6	2037	c.1813A>G	c.(1813-1815)AAA>GAA	p.K605E	ZNF483_uc004bfg.2_Intron	NM_133464	NP_597721	Q8TF39	ZN483_HUMAN	zinc finger protein 483 isoform a	605					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(1)	1						CACTGGAGAAAAACCATATTT	0.378			NA											22	31					0	0	0.014323	0	0
ASTN2	23245	broad.mit.edu	37	9	119770520	119770520	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr9:119770520C>T	uc004bjs.1	-	7	1543	c.1442G>A	c.(1441-1443)AGT>AAT	p.S481N	ASTN2_uc004bjr.1_Missense_Mutation_p.S481N|ASTN2_uc004bjt.1_Missense_Mutation_p.S430N	NM_198187	NP_937830	O75129	ASTN2_HUMAN	astrotactin 2 isoform c	481	Extracellular (Potential).					integral to membrane				skin(4)|ovary(3)|breast(1)|kidney(1)	9						GCTCCCTTCACTCACCACGAA	0.498			NA											12	57					0	0	0.001855	0	0
BAT2L1	84726	broad.mit.edu	37	9	134334625	134334625	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr9:134334625G>C	uc004can.3	+	10	1341	c.1286G>C	c.(1285-1287)CGA>CCA	p.R429P	BAT2L1_uc010mzj.1_Missense_Mutation_p.R13P	NM_013318	NP_037450	Q5JSZ5	PRC2B_HUMAN	HLA-B associated transcript 2-like	429							protein binding				0						AAGCGGACTCGAGAGGAAGGG	0.592			NA											39	111					0	0	0.010771	0	0
CEL	1056	broad.mit.edu	37	9	135947032	135947032	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr9:135947032C>A	uc010naa.1	+	11	2168	c.2152C>A	c.(2152-2154)CCG>ACG	p.P718T		NM_001807	NP_001798	P19835	CEL_HUMAN	carboxyl ester lipase precursor	715	17 X 11 AA tandem repeats, glycodomain, O-linked (mucin type).|15.				cholesterol catabolic process|fatty acid catabolic process|intestinal cholesterol absorption|intestinal lipid catabolic process|pancreatic juice secretion|protein esterification	cytosol|extracellular space	acylglycerol lipase activity|carboxylesterase activity|heparin binding|sterol esterase activity|triglyceride lipase activity			pancreas(1)	1				OV - Ovarian serous cystadenocarcinoma(145;1.03e-40)|Epithelial(140;3.58e-37)|GBM - Glioblastoma multiforme(294;0.00164)|READ - Rectum adenocarcinoma(205;0.196)		CGCCCCCGTGCCGCCCACGGG	0.731			NA											3	15					1.23904e-05	1.36604e-05	0.000602	1	0
LCN9	392399	broad.mit.edu	37	9	138556120	138556120	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr9:138556120G>T	uc004cgk.1	+	2	209	c.209G>T	c.(208-210)AGC>ATC	p.S70I		NM_001001676	NP_001001676	Q8WX39	LCN9_HUMAN	lipocalin 9	70						extracellular region	pheromone binding|transporter activity			large_intestine(2)	2		Myeloproliferative disorder(178;0.0821)		OV - Ovarian serous cystadenocarcinoma(145;3.43e-07)|Epithelial(140;1.97e-06)|all cancers(34;6.1e-05)		AAGAACGGCAGCCTAATATTT	0.473			NA											63	97					4.66136e-34	7.61356e-34	0.01441	1	0
TLR8	51311	broad.mit.edu	37	X	12938519	12938519	+	Nonsense_Mutation	SNP	C	C	T			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chrX:12938519C>T	uc004cve.2	+	2	1428	c.1360C>T	c.(1360-1362)CGA>TGA	p.R454*	TLR8_uc004cvd.2_Nonsense_Mutation_p.R472*	NM_138636	NP_619542	Q9NR97	TLR8_HUMAN	toll-like receptor 8 precursor	454	Extracellular (Potential).				cellular response to mechanical stimulus|defense response to virus|I-kappaB kinase/NF-kappaB cascade|immunoglobulin mediated immune response|inflammatory response|innate immune response|positive regulation of innate immune response|positive regulation of interferon-alpha biosynthetic process|positive regulation of interferon-beta biosynthetic process|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-8 biosynthetic process	endosome membrane	DNA binding|double-stranded RNA binding|single-stranded RNA binding|transmembrane receptor activity			ovary(4)|lung(2)|large_intestine(1)	7						TATCCGGAAACGACGCTCAAC	0.388			NA											39	28					0	0	0.010771	0	0
WAS	7454	broad.mit.edu	37	X	48546470	48546470	+	Silent	SNP	C	C	A			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chrX:48546470C>A	uc004dkm.3	+	8	819	c.762C>A	c.(760-762)CCC>CCA	p.P254P		NM_000377	NP_000368	P42768	WASP_HUMAN	Wiskott-Aldrich syndrome protein	254					blood coagulation|defense response|epidermis development|immune response|T cell receptor signaling pathway	actin cytoskeleton|cytosol	identical protein binding|small GTPase regulator activity			ovary(1)	1		all_lung(315;1.27e-10)				GGTGGGACCCCCAGAATGGAT	0.552			NA	Mis|N|F|S			lymphoma			Wiskott-Aldrich_syndrome				4	10					0.00909568	0.0093939	0.009096	1	0
OGT	8473	broad.mit.edu	37	X	70774416	70774416	+	Silent	SNP	C	C	G			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chrX:70774416C>G	uc004eaa.1	+	6	919	c.702C>G	c.(700-702)GTC>GTG	p.V234V	BCYRN1_uc011mpt.1_Intron|OGT_uc004eab.1_Silent_p.V224V|OGT_uc004eac.2_Silent_p.V95V|OGT_uc004ead.2_5'UTR	NM_181672	NP_858058	O15294	OGT1_HUMAN	O-linked GlcNAc transferase isoform 1	234	TPR 6.				cellular response to retinoic acid|positive regulation of granulocyte differentiation|positive regulation of histone H3-K4 methylation|positive regulation of proteolysis|protein O-linked glycosylation|signal transduction	cytosol|MLL5-L complex	enzyme activator activity|protein binding|protein N-acetylglucosaminyltransferase activity			ovary(3)|kidney(1)|pancreas(1)	5	Renal(35;0.156)					TAGGAAATGTCTTGAAAGAGG	0.358			NA											3	69					0	0	0.009096	0	0
COL4A5	1287	broad.mit.edu	37	X	107814662	107814662	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chrX:107814662G>T	uc004enz.1	+	7	606	c.404G>T	c.(403-405)GGC>GTC	p.G135V	COL4A5_uc011mso.1_Missense_Mutation_p.G135V	NM_033380	NP_203699	P29400	CO4A5_HUMAN	type IV collagen alpha 5 isoform 2 precursor	135	Triple-helical region.				axon guidance	collagen type IV	extracellular matrix structural constituent|protein binding			ovary(3)|central_nervous_system(1)	4						GGATTTCCAGGCAGTCCCGGT	0.373			NA							Alport_syndrome_with_Diffuse_Leiomyomatosis				64	33					3.39796e-24	5.18512e-24	0.01441	1	0
ALG13	79868	broad.mit.edu	37	X	110988103	110988103	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chrX:110988103G>A	uc011msy.1	+	24	2937	c.2903G>A	c.(2902-2904)TGT>TAT	p.C968Y	ALG13_uc011msx.1_Intron|ALG13_uc011msz.1_Missense_Mutation_p.C890Y|ALG13_uc011mta.1_Intron|ALG13_uc011mtb.1_Intron			Q9NP73	ALG13_HUMAN	SubName: Full=Asparagine-linked glycosylation 13 homolog (S. cerevisiae);	968	Pro-rich.				dolichol-linked oligosaccharide biosynthetic process|lipid glycosylation|post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane	carbohydrate binding|N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity			lung(1)	1						ccTTATTCCTGTGATCCAAGC	0.264			NA											10	4					0	0	0.013537	0	0
TRPC5	7224	broad.mit.edu	37	X	111020010	111020010	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chrX:111020010G>T	uc004epl.1	-	11	3372	c.2453C>A	c.(2452-2454)CCA>CAA	p.P818Q		NM_012471	NP_036603	Q9UL62	TRPC5_HUMAN	transient receptor potential cation channel,	818	Cytoplasmic (Potential).				axon guidance	calcium channel complex|integral to plasma membrane	protein binding|store-operated calcium channel activity			urinary_tract(1)	1						ACTGGACCTTGGCATGGTTCT	0.498			NA											89	54					2.75442e-36	4.56654e-36	0.01441	1	0
LHFPL1	340596	broad.mit.edu	37	X	111874652	111874652	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chrX:111874652G>T	uc004epq.2	-	4	992	c.659C>A	c.(658-660)CCT>CAT	p.P220H	LHFPL1_uc004epp.2_Missense_Mutation_p.P243H|LHFPL1_uc010nqa.2_RNA|LHFPL1_uc010nqb.2_Missense_Mutation_p.P187H	NM_178175	NP_835469	Q86WI0	LHPL1_HUMAN	lipoma HMGIC fusion partner-like 1 precursor	220						integral to membrane					0						CAAAGCTCAAGGTTTGAGGCA	0.463			NA											40	38					1.41504e-22	2.12255e-22	0.011902	1	0
ZSWIM5	57643	broad.mit.edu	37	1	45508890	45508890	+	Splice_Site	DEL	C	C	-			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr1:45508890delC	uc001cnd.2	-	6	1837	c.1609_splice	c.e6+1	p.E537_splice		NM_020883	NP_065934	Q9P217	ZSWM5_HUMAN	zinc finger, SWIM domain containing 5								zinc ion binding				0	Acute lymphoblastic leukemia(166;0.155)					GCTAGACTTACCAAGCCACAG	0.478			NA											39	108	---	---	---	---	NA	NA	NA	NA	NA
BCL9	607	broad.mit.edu	37	1	147091501	147091501	+	Frame_Shift_Del	DEL	C	C	-			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr1:147091501delC	uc001epq.2	+	8	2280	c.1540delC	c.(1540-1542)CCCfs	p.P514fs	BCL9_uc010ozr.1_Frame_Shift_Del_p.P440fs	NM_004326	NP_004317	O00512	BCL9_HUMAN	B-cell CLL/lymphoma 9	514	Poly-Pro.|Pro-rich.				Wnt receptor signaling pathway	nucleus	protein binding			ovary(2)|large_intestine(2)|breast(1)|skin(1)	6	all_hematologic(923;0.115)					GGTCCGAGGACCCCCCCCTCC	0.582			NA	T	IGH@|IGL@	B-ALL								7	467	---	---	---	---	NA	NA	NA	NA	NA
OBSCN	84033	broad.mit.edu	37	1	228558786	228558786	+	Frame_Shift_Del	DEL	C	C	-			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr1:228558786delC	uc009xez.1	+	94	20351	c.20307delC	c.(20305-20307)GGCfs	p.G6769fs	OBSCN_uc001hsr.1_Frame_Shift_Del_p.G1398fs	NM_001098623	NP_001092093	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and	6769					apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			stomach(8)|large_intestine(7)|breast(5)|ovary(4)|skin(2)|central_nervous_system(1)|pancreas(1)	28		Prostate(94;0.0405)				TGCTGCGGGGCCCACCCGACA	0.662			NA											60	55	---	---	---	---	NA	NA	NA	NA	NA
PBLD	64081	broad.mit.edu	37	10	70048359	70048375	+	Frame_Shift_Del	DEL	CCTGTGTTTTCAACTTG	CCTGTGTTTTCAACTTG	-			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	CCTGTGTTTTCAACTTG	CCTGTGTTTTCAACTTG	-	-	CCTGTGTTTTCAACTTG	CCTGTGTTTTCAACTTG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr10:70048359_70048375delCCTGTGTTTTCAACTTG	uc001jns.1	-	8	759_775	c.556_572delCAAGTTGAAAACACAGG	c.(556-573)CAAGTTGAAAACACAGGGfs	p.Q186fs	PBLD_uc001jnr.1_Frame_Shift_Del_p.Q153fs|PBLD_uc001jnt.1_Frame_Shift_Del_p.Q186fs|PBLD_uc001jnu.1_Frame_Shift_Del_p.Q186fs|PBLD_uc001jnv.1_3'UTR	NM_022129	NP_071412	P30039	PBLD_HUMAN	MAWD binding protein isoform a	186_191					biosynthetic process		isomerase activity			skin(2)|ovary(1)	3						TTTCACCTTCCCTGTGTTTTCAACTTGCAGCAGATTC	0.461			NA											15	152	---	---	---	---	NA	NA	NA	NA	NA
RPH3A	22895	broad.mit.edu	37	12	113303262	113303262	+	Frame_Shift_Del	DEL	G	G	-			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr12:113303262delG	uc010syl.1	+	6	636	c.274delG	c.(274-276)GGAfs	p.G92fs	RPH3A_uc001ttz.2_Frame_Shift_Del_p.G92fs|RPH3A_uc001tty.2_Frame_Shift_Del_p.G88fs|RPH3A_uc009zwe.1_Frame_Shift_Del_p.G88fs|RPH3A_uc010sym.1_Frame_Shift_Del_p.G43fs|RPH3A_uc001tua.2_5'Flank	NM_001143854	NP_001137326	Q9Y2J0	RP3A_HUMAN	rabphilin 3A homolog isoform 1	92	RabBD.|FYVE-type.				intracellular protein transport	cell junction|synaptic vesicle	Rab GTPase binding|transporter activity|zinc ion binding	p.N92N(1)		ovary(3)|central_nervous_system(2)|skin(2)	7				BRCA - Breast invasive adenocarcinoma(302;0.00453)		GAACGTGGCTGGAGATGGGGT	0.532			NA											70	167	---	---	---	---	NA	NA	NA	NA	NA
KRTAP1-1	81851	broad.mit.edu	37	17	39197262	39197262	+	Frame_Shift_Del	DEL	G	G	-			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr17:39197262delG	uc002hvw.1	-	1	452	c.388delC	c.(388-390)CTGfs	p.L130fs		NM_030967	NP_112229	Q07627	KRA11_HUMAN	keratin associated protein 1-1	130						extracellular region|keratin filament					0		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000371)			CAGGGGGGCAGGCAGGTACCC	0.667			NA											8	74	---	---	---	---	NA	NA	NA	NA	NA
RUNDC1	146923	broad.mit.edu	37	17	41143406	41143406	+	Frame_Shift_Del	DEL	G	G	-			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr17:41143406delG	uc002ici.1	+	5	1527	c.1515delG	c.(1513-1515)ACGfs	p.T505fs	RUNDC1_uc010whi.1_Frame_Shift_Del_p.T275fs	NM_173079	NP_775102	Q96C34	RUND1_HUMAN	RUN domain containing 1	505	RUN.										0		Breast(137;0.00499)		BRCA - Breast invasive adenocarcinoma(366;0.161)		TTCCTGTTACGGGAGGCACTG	0.542			NA											72	91	---	---	---	---	NA	NA	NA	NA	NA
COL5A3	50509	broad.mit.edu	37	19	10080331	10080332	+	Frame_Shift_Ins	INS	-	-	T			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr19:10080331_10080332insT	uc002mmq.1	-	56	4103_4104	c.4017_4018insA	c.(4015-4020)CCAGGGfs	p.P1339fs		NM_015719	NP_056534	P25940	CO5A3_HUMAN	collagen, type V, alpha 3 preproprotein	1339_1340	Triple-helical region.				collagen fibril organization|skin development	collagen type V	collagen binding|extracellular matrix structural constituent			ovary(7)|lung(1)|central_nervous_system(1)|skin(1)	10			Epithelial(33;7.11e-05)			CCCGTCCTCCCTGGGGGCCCAT	0.673			NA											12	36	---	---	---	---	NA	NA	NA	NA	NA
ZNF536	9745	broad.mit.edu	37	19	30935349	30935350	+	Frame_Shift_Ins	INS	-	-	T			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr19:30935349_30935350insT	uc002nsu.1	+	2	1018_1019	c.880_881insT	c.(880-882)CGCfs	p.R294fs	ZNF536_uc010edd.1_Frame_Shift_Ins_p.R294fs	NM_014717	NP_055532	O15090	ZN536_HUMAN	zinc finger protein 536	294	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(7)|large_intestine(2)|skin(2)	11	Esophageal squamous(110;0.0834)					CCGCCACATCCGCATCTTGCAC	0.644			NA											68	183	---	---	---	---	NA	NA	NA	NA	NA
PSG1	5669	broad.mit.edu	37	19	43348706	43348706	+	Frame_Shift_Del	DEL	G	G	-			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr19:43348706delG	uc002oux.1	-	5	1239	c.1090delC	c.(1090-1092)CTTfs	p.L364fs	PSG3_uc002ouf.2_Intron|PSG1_uc002oug.1_Intron|PSG11_uc002ouw.2_Intron|PSG7_uc002ous.1_Intron|PSG7_uc002out.1_Intron|PSG10_uc002ouv.1_Intron|PSG8_uc002ouj.3_Intron|PSG8_uc002ouk.3_Intron|PSG8_uc002oul.3_Intron|PSG8_uc002oum.3_Intron|PSG1_uc002oun.2_RNA|PSG8_uc002oup.3_Intron|PSG10_uc010eip.2_RNA|PSG1_uc002our.1_Intron|PSG1_uc010eio.1_Intron|PSG1_uc002ouy.1_Frame_Shift_Del_p.L342fs	NM_006905	NP_008836	P11464	PSG1_HUMAN	pregnancy specific beta-1-glycoprotein 1	350	Ig-like C2-type 3.				female pregnancy	extracellular region				ovary(2)	2		Prostate(69;0.00682)				GACAAGTAAAGGTTTTGTCCT	0.458			NA											96	212	---	---	---	---	NA	NA	NA	NA	NA
FRK	2444	broad.mit.edu	37	6	116289825	116289827	+	In_Frame_Del	DEL	TTC	TTC	-			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	TTC	TTC	-	-	TTC	TTC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr6:116289825_116289827delTTC	uc003pwi.1	-	3	989_991	c.542_544delGAA	c.(541-546)AGAATC>ATC	p.R181del		NM_002031	NP_002022	P42685	FRK_HUMAN	fyn-related kinase	181	SH2.				negative regulation of cell proliferation	cytoplasm|nucleus	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding			ovary(3)|lung(3)	6		all_cancers(87;0.00559)|all_epithelial(87;0.00738)|Colorectal(196;0.0465)		all cancers(137;0.0128)|OV - Ovarian serous cystadenocarcinoma(136;0.0209)|GBM - Glioblastoma multiforme(226;0.0459)|Epithelial(106;0.0625)		GTTGAAAAGATTCTTCTTCGCGT	0.409			NA											22	148	---	---	---	---	NA	NA	NA	NA	NA
SHPRH	257218	broad.mit.edu	37	6	146276182	146276182	+	Frame_Shift_Del	DEL	A	A	-			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr6:146276182delA	uc003qlf.2	-	2	676	c.277delT	c.(277-279)TCCfs	p.S93fs	SHPRH_uc003qld.2_Frame_Shift_Del_p.S93fs|SHPRH_uc003qle.2_Frame_Shift_Del_p.S93fs|SHPRH_uc003qlg.1_5'UTR|SHPRH_uc003qlj.1_Intron|SHPRH_uc003qlk.1_Frame_Shift_Del_p.S93fs	NM_001042683	NP_001036148	Q149N8	SHPRH_HUMAN	SNF2 histone linker PHD RING helicase isoform a	93					DNA repair|nucleosome assembly	nucleosome|nucleus	ATP binding|DNA binding|helicase activity|ligase activity|zinc ion binding			ovary(1)|kidney(1)|central_nervous_system(1)	3		Ovarian(120;0.0365)		OV - Ovarian serous cystadenocarcinoma(155;1.47e-07)|GBM - Glioblastoma multiforme(68;0.0124)		GACAAAGGGGAAAAAATACCA	0.363			NA											8	74	---	---	---	---	NA	NA	NA	NA	NA
ISCA1	81689	broad.mit.edu	37	9	88881102	88881103	+	Frame_Shift_Ins	INS	-	-	A			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chr9:88881102_88881103insA	uc004aop.2	-	4	362_363	c.245_246insT	c.(244-246)GTCfs	p.V82fs	GOLM1_uc010mqd.1_Intron	NM_030940	NP_112202	Q9BUE6	ISCA1_HUMAN	HESB like domain containing 2 precursor	82					iron-sulfur cluster assembly	mitochondrion	iron-sulfur cluster binding|metal ion binding|structural molecule activity				0				OV - Ovarian serous cystadenocarcinoma(323;5.4e-34)|Lung(182;0.0375)		TGAATACTCTGACTCCTTGGAG	0.287			NA											16	102	---	---	---	---	NA	NA	NA	NA	NA
FAM58A	92002	broad.mit.edu	37	X	152860006	152860006	+	Frame_Shift_Del	DEL	T	T	-			TCGA-05-4249-01A-01D-1105-08	TCGA-05-4249-10A-01D-1105-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	8be717b5-5b65-4631-a175-1f4c063d447e	5d48c4d0-e1bd-4a65-9ecf-b6bad02196d7	g.chrX:152860006delT	uc010nug.2	-	2	345	c.242delA	c.(241-243)AAGfs	p.K81fs				Q8N1B3	FA58A_HUMAN	RecName: Full=Cyclin-related protein FAM58B;	143					regulation of cyclin-dependent protein kinase activity|regulation of transcription, DNA-dependent		protein kinase binding				0	all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					AGTATGTACCTTGTGTGGATG	0.537			NA											76	55	---	---	---	---	NA	NA	NA	NA	NA