Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
DNAH8	1769	broad.mit.edu	37	6	38891794	38891794	+	Silent	SNP	G	G	A	rs79890174	byFrequency	TCGA-TQ-A7RQ-01A-11D-A33T-08	TCGA-TQ-A7RQ-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	adbae2bb-eb36-44ff-ad9e-1aa089cff90b	aa8b45fd-3ac5-45c8-a77a-ea08fc5c0654	g.chr6:38891794G>A	ENST00000359357.3	+	71	10421	c.10167G>A	c.(10165-10167)acG>acA	p.T3389T	DNAH8_ENST00000449981.2_Silent_p.T3606T|RP1-207H1.3_ENST00000418399.1_RNA|RP1-207H1.3_ENST00000416948.1_RNA|DNAH8_ENST00000441566.1_Silent_p.T3353T					dynein, axonemal, heavy chain 8											NS(7)|breast(9)|central_nervous_system(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(3)|kidney(16)|large_intestine(44)|liver(4)|lung(101)|ovary(7)|pancreas(2)|prostate(8)|skin(28)|stomach(4)|upper_aerodigestive_tract(6)|urinary_tract(4)	260						TGCTGTGCACGGGATTCCTTT	0.423000													6	235					0	0	1	0	0
MYO1F	4542	broad.mit.edu	37	19	8587611	8587611	+	Missense_Mutation	SNP	G	G	A			TCGA-TQ-A7RQ-01A-11D-A33T-08	TCGA-TQ-A7RQ-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	adbae2bb-eb36-44ff-ad9e-1aa089cff90b	aa8b45fd-3ac5-45c8-a77a-ea08fc5c0654	g.chr19:8587611G>A	ENST00000338257.8	-	26	3224	c.2957C>T	c.(2956-2958)tCc>tTc	p.S986F		NM_012335.3	NP_036467.2	O00160	MYO1F_HUMAN	myosin IF	986				IMSGGGTHRPPRGPPSTSLG -> KFIWPRGHPQASPALRP HPWD (in Ref. 5; CAA67058).		unconventional myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(7)|lung(13)|ovary(3)|prostate(3)|skin(3)|urinary_tract(1)	42						CAGGGATGTGGACGGAGGGCC	0.687000													20	25					0	0	1	0	0
GPR101	83550	broad.mit.edu	37	X	136113803	136113803	+	Missense_Mutation	SNP	C	C	T			TCGA-TQ-A7RQ-01A-11D-A33T-08	TCGA-TQ-A7RQ-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	adbae2bb-eb36-44ff-ad9e-1aa089cff90b	aa8b45fd-3ac5-45c8-a77a-ea08fc5c0654	g.chrX:136113803C>T	ENST00000298110.1	-	1	30	c.31G>A	c.(31-33)Gag>Aag	p.E11K		NM_054021.1	NP_473362.1	Q96P66	GP101_HUMAN	G protein-coupled receptor 101	11						integral to membrane|plasma membrane	G-protein coupled receptor activity			autonomic_ganglia(1)|endometrium(5)|kidney(2)|large_intestine(11)|lung(18)|ovary(3)|skin(1)|urinary_tract(1)	42	Acute lymphoblastic leukemia(192;0.000127)					CTGTTACTCTCGCGCGTGCTG	0.632000													41	87					0	0	1	0	0
ZNF254	9534	broad.mit.edu	37	19	24310731	24310731	+	Silent	SNP	G	G	A			TCGA-TQ-A7RQ-01A-11D-A33T-08	TCGA-TQ-A7RQ-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	adbae2bb-eb36-44ff-ad9e-1aa089cff90b	aa8b45fd-3ac5-45c8-a77a-ea08fc5c0654	g.chr19:24310731G>A	ENST00000357002.4	+	4	2044	c.1929G>A	c.(1927-1929)tcG>tcA	p.S643S	ZNF254_ENST00000342944.6_Silent_p.S558S	NM_001278661.1|NM_001278662.1|NM_001278664.1|NM_001278677.1|NM_001278678.1|NM_203282.2	NP_001265590.1|NP_001265591.1|NP_001265593.1|NP_001265606.1|NP_001265607.1|NP_975011.3	O75437	ZN254_HUMAN	zinc finger protein 254	643					negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding						all_cancers(12;0.086)|all_lung(12;0.00528)|Lung NSC(12;0.00731)|all_epithelial(12;0.0186)				ATCGGTCCTCGCACCTCACCA	0.373000													21	233					0	0	1	0	0
ANKRD36C	400986	broad.mit.edu	37	2	96593016	96593016	+	Missense_Mutation	SNP	C	C	A	rs79307257	by1000genomes	TCGA-TQ-A7RQ-01A-11D-A33T-08	TCGA-TQ-A7RQ-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	adbae2bb-eb36-44ff-ad9e-1aa089cff90b	aa8b45fd-3ac5-45c8-a77a-ea08fc5c0654	g.chr2:96593016C>A	ENST00000456556.1	-	28	1969	c.1885G>T	c.(1885-1887)Gat>Tat	p.D629Y						ankyrin repeat domain 36C									p.D629Y(1)		breast(1)|endometrium(8)|kidney(5)|lung(4)	18						GAAACAGAATCTTTCTCATCA	0.318000													5	127					2.0095e-06	2.27391e-06	1	1	0
IL6ST	3572	broad.mit.edu	37	5	55237255	55237255	+	Silent	SNP	G	G	A			TCGA-TQ-A7RQ-01A-11D-A33T-08	TCGA-TQ-A7RQ-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	adbae2bb-eb36-44ff-ad9e-1aa089cff90b	aa8b45fd-3ac5-45c8-a77a-ea08fc5c0654	g.chr5:55237255G>A	ENST00000381298.2	-	17	2724	c.2412C>T	c.(2410-2412)ggC>ggT	p.G804G	IL6ST_ENST00000381294.3_Silent_p.G743G|IL6ST_ENST00000381287.4_3'UTR|IL6ST_ENST00000502326.3_Silent_p.G804G|IL6ST_ENST00000536319.1_3'UTR|IL6ST_ENST00000336909.5_Silent_p.G804G|CTD-2031P19.5_ENST00000576302.1_RNA	NM_001190981.1|NM_002184.3|NM_175767.2	NP_001177910.1|NP_002175.2|NP_786943.1	P40189	IL6RB_HUMAN	interleukin 6 signal transducer (gp130, oncostatin M receptor)	804					interleukin-6-mediated signaling pathway|leukemia inhibitory factor signaling pathway|negative regulation of interleukin-6-mediated signaling pathway|positive regulation of anti-apoptosis|positive regulation of cardiac muscle hypertrophy|positive regulation of osteoblast differentiation|positive regulation of T cell proliferation|positive regulation of tyrosine phosphorylation of Stat1 protein|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation vascular endothelial growth factor production	ciliary neurotrophic factor receptor complex|extracellular region|extracellular space|interleukin-6 receptor complex|oncostatin-M receptor complex	ciliary neurotrophic factor receptor activity|ciliary neurotrophic factor receptor binding|growth factor binding|protein homodimerization activity			breast(2)|endometrium(5)|kidney(5)|large_intestine(4)|liver(2)|lung(1)|ovary(1)|prostate(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	26		Lung NSC(810;8.69e-05)|Prostate(74;0.00308)|Breast(144;0.0544)|Ovarian(174;0.223)				TACCATCACCGCCATCTACAT	0.443000			O		hepatocellular ca								5	251					0	0	1	0	0
SIRPA	140885	broad.mit.edu	37	20	1902206	1902206	+	Missense_Mutation	SNP	T	T	C			TCGA-TQ-A7RQ-01A-11D-A33T-08	TCGA-TQ-A7RQ-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	adbae2bb-eb36-44ff-ad9e-1aa089cff90b	aa8b45fd-3ac5-45c8-a77a-ea08fc5c0654	g.chr20:1902206T>C	ENST00000358771.4	+	3	754	c.602T>C	c.(601-603)gTa>gCa	p.V201A	SIRPA_ENST00000356025.3_Missense_Mutation_p.V201A|SIRPA_ENST00000400068.3_Missense_Mutation_p.V201A	NM_001040023.1	NP_001035112.1	P78324	SHPS1_HUMAN	signal-regulatory protein alpha	201	Ig-like C1-type 1.		VG -> AR.		blood coagulation|cell adhesion|cell junction assembly|leukocyte migration	integral to membrane|plasma membrane	SH3 domain binding			cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(13)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	21				Colorectal(46;0.018)|READ - Rectum adenocarcinoma(1;0.0556)		GTGGACCCCGTAGGAGAGAGC	0.572000													4	188					0	0	1	0	0
EIF2AK4	440275	broad.mit.edu	37	15	40257951	40257951	+	Silent	SNP	C	C	T			TCGA-TQ-A7RQ-01A-11D-A33T-08	TCGA-TQ-A7RQ-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	adbae2bb-eb36-44ff-ad9e-1aa089cff90b	aa8b45fd-3ac5-45c8-a77a-ea08fc5c0654	g.chr15:40257951C>T	ENST00000263791.5	+	8	967	c.924C>T	c.(922-924)gtC>gtT	p.V308V	EIF2AK4_ENST00000559624.1_Silent_p.V308V|EIF2AK4_ENST00000382727.2_Silent_p.V308V	NM_001013703.2	NP_001013725.2	Q9P2K8	E2AK4_HUMAN	eukaryotic translation initiation factor 2 alpha kinase 4	308	Protein kinase 1.				translation	cytosolic ribosome	aminoacyl-tRNA ligase activity|ATP binding|eukaryotic translation initiation factor 2alpha kinase activity|protein homodimerization activity			NS(1)|breast(2)|endometrium(1)|kidney(3)|large_intestine(8)|lung(18)|ovary(1)|prostate(3)|skin(2)|stomach(1)	40		all_cancers(109;1.05e-19)|all_epithelial(112;4.38e-17)|Lung NSC(122;1.09e-12)|all_lung(180;3.56e-11)|Melanoma(134;0.0575)|Ovarian(310;0.0826)|Colorectal(260;0.119)		GBM - Glioblastoma multiforme(113;5.31e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0616)		GTGGCTTTGTCTTGTTGTATG	0.398000													101	110					0	0	1	0	0
EMD	2010	broad.mit.edu	37	X	153608123	153608123	+	Silent	SNP	C	C	T			TCGA-TQ-A7RQ-01A-11D-A33T-08	TCGA-TQ-A7RQ-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	adbae2bb-eb36-44ff-ad9e-1aa089cff90b	aa8b45fd-3ac5-45c8-a77a-ea08fc5c0654	g.chrX:153608123C>T	ENST00000369842.4	+	2	444	c.156C>T	c.(154-156)agC>agT	p.S52S	EMD_ENST00000369835.3_Intron|EMD_ENST00000492448.1_3'UTR	NM_000117.2	NP_000108.1	P50402	EMD_HUMAN	emerin	52	Interaction with F-actin (Probable).				cellular response to growth factor stimulus|muscle contraction|muscle organ development|negative regulation of catenin import into nucleus|negative regulation of fibroblast proliferation|positive regulation of protein export from nucleus|regulation of canonical Wnt receptor signaling pathway	endoplasmic reticulum|integral to membrane|microtubule|nuclear inner membrane|nuclear outer membrane	actin binding|beta-tubulin binding			lung(5)	5	all_cancers(53;3.7e-16)|all_epithelial(53;2.97e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					CGCCCCCCAGCTCGTCCGCCG	0.672000													61	85					0	0	1	0	0
UGT2B28	54490	broad.mit.edu	37	4	70152481	70152481	+	Silent	SNP	A	A	G	rs141618560		TCGA-TQ-A7RQ-01A-11D-A33T-08	TCGA-TQ-A7RQ-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	adbae2bb-eb36-44ff-ad9e-1aa089cff90b	aa8b45fd-3ac5-45c8-a77a-ea08fc5c0654	g.chr4:70152481A>G	ENST00000335568.5	+	3	884	c.882A>G	c.(880-882)gaA>gaG	p.E294E	UGT2B28_ENST00000511240.1_Silent_p.E294E	NM_053039.1	NP_444267.1	Q9BY64	UDB28_HUMAN	UDP glucuronosyltransferase 2 family, polypeptide B28	294					xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity	p.E294E(1)		central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(16)|pancreas(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	31					Flunitrazepam(DB01544)	AAATGGAGGAATTTGTACAGA	0.393000													4	215					0	0	1	0	0
DNAH10	196385	broad.mit.edu	37	12	124297882	124297882	+	Missense_Mutation	SNP	A	A	G			TCGA-TQ-A7RQ-01A-11D-A33T-08	TCGA-TQ-A7RQ-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	adbae2bb-eb36-44ff-ad9e-1aa089cff90b	aa8b45fd-3ac5-45c8-a77a-ea08fc5c0654	g.chr12:124297882A>G	ENST00000409039.3	+	19	2987	c.2962A>G	c.(2962-2964)Aag>Gag	p.K988E		NM_207437.3	NP_997320.2	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	988	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(14)|ovary(4)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	52	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		CAATCTTATGAAGTATCTACA	0.373000													4	240					0	0	1	0	0
ACP1	52	broad.mit.edu	37	2	277249	277249	+	Missense_Mutation	SNP	C	C	T			TCGA-TQ-A7RQ-01A-11D-A33T-08	TCGA-TQ-A7RQ-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	adbae2bb-eb36-44ff-ad9e-1aa089cff90b	aa8b45fd-3ac5-45c8-a77a-ea08fc5c0654	g.chr2:277249C>T	ENST00000272067.6	+	6	518	c.422C>T	c.(421-423)aCg>aTg	p.T141M	ACP1_ENST00000484464.1_3'UTR|ACP1_ENST00000272065.5_Missense_Mutation_p.T141M	NM_007099.3	NP_009030.1	P24666	PPAC_HUMAN	acid phosphatase 1, soluble	141						cytoplasm|internal side of plasma membrane|nucleus|soluble fraction	acid phosphatase activity|identical protein binding|non-membrane spanning protein tyrosine phosphatase activity			endometrium(1)|large_intestine(3)|lung(6)|prostate(1)|skin(1)	12	all_hematologic(175;0.0429)|Acute lymphoblastic leukemia(172;0.0627)	all_cancers(51;0.00175)|Lung NSC(108;0.216)|all_epithelial(98;0.236)		all cancers(51;0.000391)|Epithelial(75;0.00281)|OV - Ovarian serous cystadenocarcinoma(76;0.00542)|GBM - Glioblastoma multiforme(21;0.127)		GACTTTGAGACGGTGTACCAG	0.498000													76	106					0	0	1	0	0
MARCH5	54708	broad.mit.edu	37	10	94110927	94110927	+	Missense_Mutation	SNP	G	G	A			TCGA-TQ-A7RQ-01A-11D-A33T-08	TCGA-TQ-A7RQ-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	adbae2bb-eb36-44ff-ad9e-1aa089cff90b	aa8b45fd-3ac5-45c8-a77a-ea08fc5c0654	g.chr10:94110927G>A	ENST00000358935.2	+	6	1132	c.800G>A	c.(799-801)cGc>cAc	p.R267H		NM_017824.4	NP_060294.1	Q9NX47	MARH5_HUMAN	membrane-associated ring finger (C3HC4) 5	267					cell aging|protein autoubiquitination|protein localization in mitochondrion|protein polyubiquitination|regulation of mitochondrial fission	endoplasmic reticulum membrane|integral to membrane|mitochondrial outer membrane	GTPase binding|ubiquitin-protein ligase activity|zinc ion binding			endometrium(1)|kidney(2)|large_intestine(1)|lung(3)|skin(1)|urinary_tract(1)	9						CAGGCACACCGCAAAATTCTG	0.353000													4	210					0	0	1	0	0
IGFBP1	3484	broad.mit.edu	37	7	45930166	45930166	+	Silent	SNP	C	C	T			TCGA-TQ-A7RQ-01A-11D-A33T-08	TCGA-TQ-A7RQ-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	adbae2bb-eb36-44ff-ad9e-1aa089cff90b	aa8b45fd-3ac5-45c8-a77a-ea08fc5c0654	g.chr7:45930166C>T	ENST00000275525.3	+	2	665	c.369C>T	c.(367-369)agC>agT	p.S123S	IGFBP1_ENST00000468955.1_Silent_p.S123S|IGFBP1_ENST00000457280.1_Silent_p.S123S	NM_000596.2	NP_000587.1	P08833	IBP1_HUMAN	insulin-like growth factor binding protein 1	123						extracellular space	insulin-like growth factor binding			large_intestine(2)|lung(4)	6						GCCCTGAAAGCCCAGAGAGCA	0.552000													4	121					0	0	1	0	0
CDX4	1046	broad.mit.edu	37	X	72667179	72667179	+	Silent	SNP	C	C	T			TCGA-TQ-A7RQ-01A-11D-A33T-08	TCGA-TQ-A7RQ-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	adbae2bb-eb36-44ff-ad9e-1aa089cff90b	aa8b45fd-3ac5-45c8-a77a-ea08fc5c0654	g.chrX:72667179C>T	ENST00000373514.2	+	1	90	c.90C>T	c.(88-90)ggC>ggT	p.G30G		NM_005193.1	NP_005184.1	O14627	CDX4_HUMAN	caudal type homeobox 4	30						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(4)|kidney(1)|large_intestine(1)|lung(11)|skin(1)	18	Renal(35;0.156)					CTGGGACAGGCGGCACAGGGG	0.607000													41	52					0	0	1	0	0
AC008103.5	0	broad.mit.edu	37	22	18846121	18846121	+	RNA	SNP	C	C	T	rs4302302		TCGA-TQ-A7RQ-01A-11D-A33T-08	TCGA-TQ-A7RQ-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	adbae2bb-eb36-44ff-ad9e-1aa089cff90b	aa8b45fd-3ac5-45c8-a77a-ea08fc5c0654	g.chr22:18846121C>T	ENST00000412938.1	+	0	3479																											CACGCACTGGCGCACGATGTA	0.617000													7	49					0	0	1	0	0
DDC	1644	broad.mit.edu	37	7	50595897	50595897	+	Missense_Mutation	SNP	G	G	A	rs150760434		TCGA-TQ-A7RQ-01A-11D-A33T-08	TCGA-TQ-A7RQ-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	adbae2bb-eb36-44ff-ad9e-1aa089cff90b	aa8b45fd-3ac5-45c8-a77a-ea08fc5c0654	g.chr7:50595897G>A	ENST00000444124.2	-	6	852	c.652C>T	c.(652-654)Cgt>Tgt	p.R218C	DDC_ENST00000426377.1_Missense_Mutation_p.R140C|DDC_ENST00000357936.5_Missense_Mutation_p.R218C|DDC_ENST00000489162.1_5'UTR|DDC_ENST00000380984.4_Missense_Mutation_p.R218C|DDC_ENST00000431062.1_Intron	NM_001082971.1	NP_001076440.1	P20711	DDC_HUMAN	dopa decarboxylase (aromatic L-amino acid decarboxylase)	218					cellular amino acid metabolic process|hormone biosynthetic process|neurotransmitter secretion	cytosol	aromatic-L-amino-acid decarboxylase activity|protein binding|pyridoxal phosphate binding			breast(1)|endometrium(4)|kidney(3)|large_intestine(2)|lung(23)|ovary(4)|skin(2)|stomach(1)	40	Glioma(55;0.08)|all_neural(89;0.245)				Amantadine(DB00915)|Carbidopa(DB00190)|Flupenthixol(DB00875)|L-Tryptophan(DB00150)|Levodopa(DB01235)|Pimozide(DB01100)|Pyridoxal Phosphate(DB00114)|Remoxipride(DB00409)	GCAGACGCACGCATGGCGAAG	0.532000													4	158					0	0	1	0	0
CAB39	51719	broad.mit.edu	37	2	231682512	231682512	+	Missense_Mutation	SNP	T	T	C			TCGA-TQ-A7RQ-01A-11D-A33T-08	TCGA-TQ-A7RQ-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	adbae2bb-eb36-44ff-ad9e-1aa089cff90b	aa8b45fd-3ac5-45c8-a77a-ea08fc5c0654	g.chr2:231682512T>C	ENST00000258418.5	+	8	1166	c.737T>C	c.(736-738)aTg>aCg	p.M246T	CAB39_ENST00000409788.3_Missense_Mutation_p.M246T|CAB39_ENST00000410084.3_Missense_Mutation_p.M246T	NM_016289.3	NP_057373.1	Q9Y376	CAB39_HUMAN	calcium binding protein 39	246					cell cycle arrest|insulin receptor signaling pathway|regulation of fatty acid oxidation	cytosol	kinase binding			central_nervous_system(1)|large_intestine(1)|skin(1)	3		all_lung(227;4.63e-07)|all_hematologic(139;1.83e-06)|Lung NSC(271;2.11e-05)|Acute lymphoblastic leukemia(138;5.51e-05)|Hepatocellular(293;0.0207)|Lung SC(224;0.187)		all cancers(144;1.64e-12)|Epithelial(121;5.29e-11)|LUSC - Lung squamous cell carcinoma(224;0.0154)|Lung(119;0.0177)|COAD - Colon adenocarcinoma(134;0.226)		TTCACAATTATGACAAAATAC	0.343000													93	101					0	0	1	0	0
DNAH7	56171	broad.mit.edu	37	2	196788467	196788467	+	Missense_Mutation	SNP	C	C	T			TCGA-TQ-A7RQ-01A-11D-A33T-08	TCGA-TQ-A7RQ-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	adbae2bb-eb36-44ff-ad9e-1aa089cff90b	aa8b45fd-3ac5-45c8-a77a-ea08fc5c0654	g.chr2:196788467C>T	ENST00000312428.6	-	23	3777	c.3677G>A	c.(3676-3678)gGc>gAc	p.G1226D		NM_018897.2	NP_061720.2	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	1226	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(4)|breast(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(28)|liver(3)|lung(100)|ovary(4)|prostate(5)|skin(26)|upper_aerodigestive_tract(2)|urinary_tract(3)	205						GGACAATTTGCCACGCACCAA	0.383000													4	151					0	0	1	0	0
C1QL2	165257	broad.mit.edu	37	2	119914554	119914554	+	Missense_Mutation	SNP	G	G	A			TCGA-TQ-A7RQ-01A-11D-A33T-08	TCGA-TQ-A7RQ-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	adbae2bb-eb36-44ff-ad9e-1aa089cff90b	aa8b45fd-3ac5-45c8-a77a-ea08fc5c0654	g.chr2:119914554G>A	ENST00000272520.3	-	2	1307	c.688C>T	c.(688-690)Cgg>Tgg	p.R230W		NM_182528.3	NP_872334.2	Q7Z5L3	C1QL2_HUMAN	complement component 1, q subcomponent-like 2	230	C1q.					collagen				NS(1)|endometrium(1)|large_intestine(3)|pancreas(1)|prostate(1)	7						GCGCTGGCCCGGACCTGGGGA	0.657000										HNSCC(49;0.14)			4	215					0	0	1	0	0
TECTB	6975	broad.mit.edu	37	10	114057887	114057887	+	Silent	SNP	C	C	T			TCGA-TQ-A7RQ-01A-11D-A33T-08	TCGA-TQ-A7RQ-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	adbae2bb-eb36-44ff-ad9e-1aa089cff90b	aa8b45fd-3ac5-45c8-a77a-ea08fc5c0654	g.chr10:114057887C>T	ENST00000369422.3	+	7	732	c.732C>T	c.(730-732)ttC>ttT	p.F244F		NM_058222.1	NP_478129.1	Q96PL2	TECTB_HUMAN	tectorin beta	244	ZP.					anchored to membrane|plasma membrane|proteinaceous extracellular matrix				kidney(2)|large_intestine(3)|lung(9)|ovary(1)|pancreas(1)|skin(1)|upper_aerodigestive_tract(2)	19		Colorectal(252;0.198)		Epithelial(162;0.0143)|all cancers(201;0.0242)		GGGCAACCTTCCAATTCAATG	0.522000													40	63					0	0	1	0	0
IDH1	3417	broad.mit.edu	37	2	209113112	209113112	+	Missense_Mutation	SNP	C	C	T	rs121913500		TCGA-TQ-A7RQ-01A-11D-A33T-08	TCGA-TQ-A7RQ-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	adbae2bb-eb36-44ff-ad9e-1aa089cff90b	aa8b45fd-3ac5-45c8-a77a-ea08fc5c0654	g.chr2:209113112C>T	ENST00000415913.1	-	4	776	c.395G>A	c.(394-396)cGt>cAt	p.R132H	IDH1_ENST00000345146.2_Missense_Mutation_p.R132H|IDH1_ENST00000446179.1_Missense_Mutation_p.R132H			O75874	IDHC_HUMAN	isocitrate dehydrogenase 1 (NADP+), soluble	132			R -> C (in colorectal cancer and glioma samples; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha- ketoglutarate but instead alpha- ketoglutarate is converted to R(-)-2- hydroxyglutarate).|R -> G (in a glioma sample; glioblastoma multiforme; somatic mutation).|R -> H (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> L (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> S (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).		2-oxoglutarate metabolic process|cellular lipid metabolic process|glyoxylate cycle|isocitrate metabolic process|NADPH regeneration|tricarboxylic acid cycle	cytosol|peroxisomal matrix	isocitrate dehydrogenase (NADP+) activity|magnesium ion binding|NAD binding|protein homodimerization activity	p.R132H(2774)|p.R132L(59)|p.R132V(1)|p.G131_R132>VL(1)		NS(1)|autonomic_ganglia(2)|biliary_tract(24)|bone(237)|central_nervous_system(3764)|endometrium(3)|haematopoietic_and_lymphoid_tissue(794)|kidney(2)|large_intestine(7)|lung(7)|prostate(6)|skin(5)|soft_tissue(12)|thyroid(22)|urinary_tract(1)	4887				Epithelial(149;0.0322)|LUSC - Lung squamous cell carcinoma(261;0.0711)|Lung(261;0.136)		ATAAGCATGACGACCTATGAT	0.393000			Mis		gliobastoma								66	84					0	0	1	0	0
SEC22C	9117	broad.mit.edu	37	3	42594904	42594904	+	Missense_Mutation	SNP	T	T	C			TCGA-TQ-A7RQ-01A-11D-A33T-08	TCGA-TQ-A7RQ-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	adbae2bb-eb36-44ff-ad9e-1aa089cff90b	aa8b45fd-3ac5-45c8-a77a-ea08fc5c0654	g.chr3:42594904T>C	ENST00000264454.3	-	7	891	c.748A>G	c.(748-750)Atg>Gtg	p.M250V	SEC22C_ENST00000536332.1_Intron|SEC22C_ENST00000417572.1_Intron|SEC22C_ENST00000423701.2_Intron|SEC22C_ENST00000273156.7_Intron			Q9BRL7	SC22C_HUMAN	SEC22 vesicle trafficking protein homolog C (S. cerevisiae)	250					ER to Golgi vesicle-mediated transport|protein transport	endoplasmic reticulum membrane|integral to membrane				endometrium(1)|large_intestine(2)	3				KIRC - Kidney renal clear cell carcinoma(284;0.222)		ACCACCTTCATAGTCCTGGCT	0.448000													31	49					0	0	1	0	0
F8	2157	broad.mit.edu	37	X	154158011	154158011	+	Missense_Mutation	SNP	C	C	T			TCGA-TQ-A7RQ-01A-11D-A33T-08	TCGA-TQ-A7RQ-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	adbae2bb-eb36-44ff-ad9e-1aa089cff90b	aa8b45fd-3ac5-45c8-a77a-ea08fc5c0654	g.chrX:154158011C>T	ENST00000360256.4	-	14	4254	c.4054G>A	c.(4054-4056)Gtg>Atg	p.V1352M		NM_000132.3	NP_000123.1	P00451	FA8_HUMAN	coagulation factor VIII, procoagulant component	1352	B.				acute-phase response|blood coagulation, intrinsic pathway|cell adhesion|platelet activation|platelet degranulation	extracellular space|plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity|protein binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(27)|liver(1)|lung(47)|ovary(5)|pancreas(3)|prostate(1)|skin(5)|upper_aerodigestive_tract(5)|urinary_tract(2)	120	all_cancers(53;7.19e-17)|all_epithelial(53;9.83e-11)|all_lung(58;6.63e-07)|Lung NSC(58;2.08e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)				Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Drotrecogin alfa(DB00055)	GTGTCATCCACAATTATCCTT	0.423000													6	457					0	0	1	0	0
ASB9	140462	broad.mit.edu	37	X	15268608	15268608	+	Missense_Mutation	SNP	A	A	T			TCGA-TQ-A7RQ-01A-11D-A33T-08	TCGA-TQ-A7RQ-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	adbae2bb-eb36-44ff-ad9e-1aa089cff90b	aa8b45fd-3ac5-45c8-a77a-ea08fc5c0654	g.chrX:15268608A>T	ENST00000546332.1	-	6	995	c.512T>A	c.(511-513)cTc>cAc	p.L171H	ASB9_ENST00000473862.1_5'UTR|ASB9_ENST00000380483.3_Missense_Mutation_p.L161H|ASB9_ENST00000380485.3_Missense_Mutation_p.L171H|ASB9_ENST00000380488.4_Missense_Mutation_p.L171H	NM_001168531.1	NP_001162003.1	Q96DX5	ASB9_HUMAN	ankyrin repeat and SOCS box containing 9	171					intracellular signal transduction					breast(1)|cervix(1)|kidney(1)|large_intestine(2)|lung(10)	15	Hepatocellular(33;0.183)					AGCCAAATAGAGTGGAGTGCC	0.458000													9	246					0	0	1	0	0
LRBA	987	broad.mit.edu	37	4	151792590	151792590	+	Silent	SNP	G	G	A			TCGA-TQ-A7RQ-01A-11D-A33T-08	TCGA-TQ-A7RQ-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	adbae2bb-eb36-44ff-ad9e-1aa089cff90b	aa8b45fd-3ac5-45c8-a77a-ea08fc5c0654	g.chr4:151792590G>A	ENST00000535741.1	-	19	2747	c.2274C>T	c.(2272-2274)gtC>gtT	p.V758V	LRBA_ENST00000357115.3_Silent_p.V758V|LRBA_ENST00000507224.1_Silent_p.V758V|LRBA_ENST00000510413.1_Silent_p.V758V			P50851	LRBA_HUMAN	LPS-responsive vesicle trafficking, beach and anchor containing	758						endoplasmic reticulum|Golgi apparatus|integral to membrane|lysosome|plasma membrane	protein binding			breast(6)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(20)|lung(32)|ovary(4)|prostate(6)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	91	all_hematologic(180;0.151)					GTCCAAGCATGACTTCTGCTT	0.373000													33	131					0	0	1	0	0
MUC5B	727897	broad.mit.edu	37	11	1265999	1265999	+	Missense_Mutation	SNP	T	T	C			TCGA-TQ-A7RQ-01A-11D-A33T-08	TCGA-TQ-A7RQ-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	adbae2bb-eb36-44ff-ad9e-1aa089cff90b	aa8b45fd-3ac5-45c8-a77a-ea08fc5c0654	g.chr11:1265999T>C	ENST00000447027.1	+	31	7956	c.7898T>C	c.(7897-7899)cTt>cCt	p.L2633P	RP11-532E4.2_ENST00000532061.2_RNA|MUC5B_ENST00000529681.1_Missense_Mutation_p.L2630P			Q9HC84	MUC5B_HUMAN	mucin 5B, oligomeric mucus/gel-forming	2630	11 X approximate tandem repeats, Ser/Thr- rich.|7 X Cys-rich subdomain repeats.|Thr-rich.			Missing (in Ref. 6; AAB61398).	cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding	p.L2630P(1)|p.L2609P(1)		cervix(2)|endometrium(36)|kidney(9)|lung(89)|urinary_tract(1)	137		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		GCACGCACGCTTCCAGTGTGG	0.637000													4	147					0	0	1	0	0
ELMO3	79767	broad.mit.edu	37	16	67235520	67235520	+	Missense_Mutation	SNP	G	G	A			TCGA-TQ-A7RQ-01A-11D-A33T-08	TCGA-TQ-A7RQ-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	adbae2bb-eb36-44ff-ad9e-1aa089cff90b	aa8b45fd-3ac5-45c8-a77a-ea08fc5c0654	g.chr16:67235520G>A	ENST00000393997.2	+	10	1109	c.1052G>A	c.(1051-1053)cGg>cAg	p.R351Q	ELMO3_ENST00000360833.1_Missense_Mutation_p.R334Q|ELMO3_ENST00000477898.1_Missense_Mutation_p.R185Q	NM_024712.3	NP_078988.2	Q96BJ8	ELMO3_HUMAN	engulfment and cell motility 3	298	ELMO.				apoptosis|phagocytosis	cytoplasm|cytoskeleton	SH3 domain binding	p.R351Q(2)		cervix(2)|kidney(4)|large_intestine(3)|lung(3)|ovary(2)|prostate(1)|upper_aerodigestive_tract(3)	18		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.00067)|Epithelial(162;0.00442)|all cancers(182;0.0417)		CCGCGCATGCGGACGCCCCTG	0.587000													17	98					0	0	1	0	0
MIER2	54531	broad.mit.edu	37	19	313566	313566	+	Missense_Mutation	SNP	C	C	T			TCGA-TQ-A7RQ-01A-11D-A33T-08	TCGA-TQ-A7RQ-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	adbae2bb-eb36-44ff-ad9e-1aa089cff90b	aa8b45fd-3ac5-45c8-a77a-ea08fc5c0654	g.chr19:313566C>T	ENST00000264819.4	-	8	743	c.733G>A	c.(733-735)Gcg>Acg	p.A245T		NM_017550.1	NP_060020.1	Q8N344	MIER2_HUMAN	mesoderm induction early response 1, family member 2	245	ELM2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			endometrium(4)|kidney(1)|large_intestine(5)|lung(8)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	22		all_cancers(10;1.05e-30)|all_epithelial(18;3.04e-19)|Acute lymphoblastic leukemia(61;4.36e-14)|all_hematologic(61;4.84e-09)|Lung NSC(49;2.49e-05)|all_lung(49;4.36e-05)|Breast(49;0.000304)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CGCTTCACCGCCCTGTACAGG	0.637000													15	192					0	0	1	0	0
GFOD1	54438	broad.mit.edu	37	6	13365582	13365582	+	Missense_Mutation	SNP	C	C	T			TCGA-TQ-A7RQ-01A-11D-A33T-08	TCGA-TQ-A7RQ-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	adbae2bb-eb36-44ff-ad9e-1aa089cff90b	aa8b45fd-3ac5-45c8-a77a-ea08fc5c0654	g.chr6:13365582C>T	ENST00000379287.3	-	2	1230	c.566G>A	c.(565-567)gGc>gAc	p.G189D	GFOD1_ENST00000379284.1_Missense_Mutation_p.G86D	NM_018988.3	NP_061861.1	Q9NXC2	GFOD1_HUMAN	glucose-fructose oxidoreductase domain containing 1	189						extracellular region	binding|oxidoreductase activity			central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(4)|lung(6)|ovary(2)	18	Breast(50;0.0296)|Ovarian(93;0.0454)	all_hematologic(90;0.135)	Epithelial(50;0.0348)|BRCA - Breast invasive adenocarcinoma(129;0.1)|all cancers(50;0.108)			GGCCTTTTGGCCGGTGAGGAA	0.602000													4	50					0	0	1	0	0
IKZF3	22806	broad.mit.edu	37	17	37922280	37922280	+	Silent	SNP	C	C	T			TCGA-TQ-A7RQ-01A-11D-A33T-08	TCGA-TQ-A7RQ-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	adbae2bb-eb36-44ff-ad9e-1aa089cff90b	aa8b45fd-3ac5-45c8-a77a-ea08fc5c0654	g.chr17:37922280C>T	ENST00000346872.3	-	8	1354	c.1293G>A	c.(1291-1293)ccG>ccA	p.P431P	IKZF3_ENST00000467757.1_Silent_p.P375P|IKZF3_ENST00000377952.2_Silent_p.P210P|IKZF3_ENST00000346243.3_Silent_p.P353P|IKZF3_ENST00000583368.1_Silent_p.P184P|IKZF3_ENST00000439167.2_Silent_p.P358P|IKZF3_ENST00000439016.2_Silent_p.P336P|IKZF3_ENST00000377945.3_Silent_p.P297P|IKZF3_ENST00000394189.2_Silent_p.P249P|IKZF3_ENST00000377944.3_Silent_p.P288P|IKZF3_ENST00000351680.3_Silent_p.P392P|IKZF3_ENST00000535189.1_Silent_p.P397P|IKZF3_ENST00000350532.3_Silent_p.P392P|IKZF3_ENST00000377958.2_Silent_p.P344P	NM_012481.4	NP_036613.2	Q9UKT9	IKZF3_HUMAN	IKAROS family zinc finger 3 (Aiolos)	431					B cell activation|mesoderm development|regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(5)|kidney(6)|large_intestine(4)|liver(1)|lung(13)|ovary(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	42	Breast(7;4.5e-103)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)		UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|Colorectal(5;6.23e-08)|COAD - Colon adenocarcinoma(5;8.58e-06)|Lung(15;0.00193)|LUAD - Lung adenocarcinoma(14;0.0664)|LUSC - Lung squamous cell carcinoma(15;0.171)			GGCAGATGGGCGGGGGCTTGA	0.552000													17	219					0	0	1	0	0
RP11-114H24.7	0	broad.mit.edu	37	15	78211548	78211548	+	RNA	SNP	T	T	C			TCGA-TQ-A7RQ-01A-11D-A33T-08	TCGA-TQ-A7RQ-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	adbae2bb-eb36-44ff-ad9e-1aa089cff90b	aa8b45fd-3ac5-45c8-a77a-ea08fc5c0654	g.chr15:78211548T>C	ENST00000565869.1	+	0	111				RP11-114H24.2_ENST00000567226.1_RNA																							CCACCTGGGATTGGAGCTTTC	0.562000													5	264					0	0	1	0	0
IGSF8	93185	broad.mit.edu	37	1	160063551	160063551	+	Missense_Mutation	SNP	G	G	T			TCGA-TQ-A7RQ-01A-11D-A33T-08	TCGA-TQ-A7RQ-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	adbae2bb-eb36-44ff-ad9e-1aa089cff90b	aa8b45fd-3ac5-45c8-a77a-ea08fc5c0654	g.chr1:160063551G>T	ENST00000368086.1	-	3	1069	c.853C>A	c.(853-855)Cag>Aag	p.Q285K	IGSF8_ENST00000314485.7_Missense_Mutation_p.Q285K|IGSF8_ENST00000460351.1_5'UTR			Q969P0	IGSF8_HUMAN	immunoglobulin superfamily, member 8	285	Ig-like C2-type 2.				cell proliferation|cellular component movement|nervous system development|single fertilization|skeletal muscle tissue development	integral to membrane	protein binding			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(19)|pancreas(1)|prostate(1)|skin(1)	33	all_cancers(52;1.11e-16)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)|LUSC - Lung squamous cell carcinoma(543;0.246)			TCTGCAATCTGGGCCCAGCTG	0.607000													3	43					1	1	1	1	0
AC008103.5	0	broad.mit.edu	37	22	18846098	18846098	+	RNA	SNP	G	G	A	rs9306211		TCGA-TQ-A7RQ-01A-11D-A33T-08	TCGA-TQ-A7RQ-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	adbae2bb-eb36-44ff-ad9e-1aa089cff90b	aa8b45fd-3ac5-45c8-a77a-ea08fc5c0654	g.chr22:18846098G>A	ENST00000412938.1	+	0	3456																											ATGCCTCGGCGCTCGATCTCC	0.622000													8	53					0	0	1	0	0
CCT6P1	0	broad.mit.edu	37	7	65222986	65222986	+	RNA	SNP	G	G	T			TCGA-TQ-A7RQ-01A-11D-A33T-08	TCGA-TQ-A7RQ-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	adbae2bb-eb36-44ff-ad9e-1aa089cff90b	aa8b45fd-3ac5-45c8-a77a-ea08fc5c0654	g.chr7:65222986G>T	ENST00000442266.1	+	0	578																											GAATTCTGGCGTTTTTTACAA	0.289000													3	26					0.115264	0.122379	1	1	0
UNC45A	55898	broad.mit.edu	37	15	91486160	91486160	+	Missense_Mutation	SNP	A	A	T			TCGA-TQ-A7RQ-01A-11D-A33T-08	TCGA-TQ-A7RQ-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	adbae2bb-eb36-44ff-ad9e-1aa089cff90b	aa8b45fd-3ac5-45c8-a77a-ea08fc5c0654	g.chr15:91486160A>T	ENST00000394275.2	+	11	1665	c.830A>T	c.(829-831)aAg>aTg	p.K277M	UNC45A_ENST00000418476.2_Missense_Mutation_p.K292M|UNC45A_ENST00000553671.2_3'UTR	NM_001039675.1	NP_001034764.1	Q9H3U1	UN45A_HUMAN	unc-45 homolog A (C. elegans)	292					cell differentiation|muscle organ development	nucleus|perinuclear region of cytoplasm	protein binding			breast(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(7)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	25	Lung NSC(78;0.0771)|all_lung(78;0.137)		Lung(145;0.189)			CGGGAGCTGAAGGTCCTCATC	0.572000													4	261					0	0	1	0	0
AHRR	57491	broad.mit.edu	37	5	428114	428114	+	Missense_Mutation	SNP	G	G	T			TCGA-TQ-A7RQ-01A-11D-A33T-08	TCGA-TQ-A7RQ-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	adbae2bb-eb36-44ff-ad9e-1aa089cff90b	aa8b45fd-3ac5-45c8-a77a-ea08fc5c0654	g.chr5:428114G>T	ENST00000316418.5	+	9	1011	c.967G>T	c.(967-969)Gat>Tat	p.D323Y	AHRR_ENST00000512529.1_Missense_Mutation_p.D151Y|AHRR_ENST00000506456.1_Missense_Mutation_p.D161Y|AHRR_ENST00000505113.1_Missense_Mutation_p.D305Y	NM_020731.4	NP_065782.2	A9YTQ3	AHRR_HUMAN	aryl-hydrocarbon receptor repressor	305					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|signal transducer activity			breast(2)|endometrium(4)|large_intestine(1)|lung(12)|prostate(1)	20			Epithelial(17;0.0011)|OV - Ovarian serous cystadenocarcinoma(19;0.00353)|all cancers(22;0.00354)|Lung(60;0.0863)			AGCCACCGCGGATGCAAAGTG	0.587000													3	32					1	1	1	1	0
LCP1	3936	broad.mit.edu	37	13	46718596	46718596	+	Nonsense_Mutation	SNP	G	G	A			TCGA-TQ-A7RQ-01A-11D-A33T-08	TCGA-TQ-A7RQ-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	adbae2bb-eb36-44ff-ad9e-1aa089cff90b	aa8b45fd-3ac5-45c8-a77a-ea08fc5c0654	g.chr13:46718596G>A	ENST00000398576.2	-	14	1622	c.1234C>T	c.(1234-1236)Cga>Tga	p.R412*	LCP1_ENST00000323076.2_Nonsense_Mutation_p.R412*			P13796	PLSL_HUMAN	lymphocyte cytosolic protein 1 (L-plastin)	412	Actin-binding 2.|CH 3.				regulation of intracellular protein transport|T cell activation involved in immune response	cell junction|cytosol|ruffle membrane	calcium ion binding			breast(2)|kidney(1)|large_intestine(6)|lung(18)|ovary(4)|prostate(2)|skin(1)	34		Lung NSC(96;1.27e-05)|Breast(56;8.04e-05)|Prostate(109;0.00217)|Hepatocellular(98;0.0207)|Lung SC(185;0.0262)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;5.39e-05)		TGATTGACTCGAGGGTTAACA	0.418000			T	BCL6	NHL								6	215					0	0	1	0	0
USP11	8237	broad.mit.edu	37	X	47099838	47099838	+	Missense_Mutation	SNP	G	G	A			TCGA-TQ-A7RQ-01A-11D-A33T-08	TCGA-TQ-A7RQ-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	adbae2bb-eb36-44ff-ad9e-1aa089cff90b	aa8b45fd-3ac5-45c8-a77a-ea08fc5c0654	g.chrX:47099838G>A	ENST00000377107.2	+	5	1024	c.670G>A	c.(670-672)Gag>Aag	p.E224K	USP11_ENST00000218348.3_Missense_Mutation_p.E267K			P51784	UBP11_HUMAN	ubiquitin specific peptidase 11	267					protein deubiquitination|ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			breast(2)|central_nervous_system(2)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(14)|ovary(3)|pancreas(1)|stomach(1)	40						TGCGGCCCTTGAGACTGGGCA	0.557000													4	92					0	0	1	0	0
USP38	84640	broad.mit.edu	37	4	144135159	144135159	+	Missense_Mutation	SNP	C	C	A			TCGA-TQ-A7RQ-01A-11D-A33T-08	TCGA-TQ-A7RQ-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	adbae2bb-eb36-44ff-ad9e-1aa089cff90b	aa8b45fd-3ac5-45c8-a77a-ea08fc5c0654	g.chr4:144135159C>A	ENST00000307017.4	+	9	2536	c.2030C>A	c.(2029-2031)aCc>aAc	p.T677N	USP38_ENST00000510377.1_Missense_Mutation_p.T677N	NM_032557.5	NP_115946.2	Q8NB14	UBP38_HUMAN	ubiquitin specific peptidase 38	677					ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity			breast(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(9)|lung(12)|ovary(1)|pancreas(1)|prostate(2)|urinary_tract(3)	33	all_hematologic(180;0.158)					AATGAAAAAACCATAGGCAGT	0.403000													5	209					1	1	1	1	0
LYZL4	131375	broad.mit.edu	37	3	42448742	42448742	+	Translation_Start_Site	SNP	A	A	G			TCGA-TQ-A7RQ-01A-11D-A33T-08	TCGA-TQ-A7RQ-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	adbae2bb-eb36-44ff-ad9e-1aa089cff90b	aa8b45fd-3ac5-45c8-a77a-ea08fc5c0654	g.chr3:42448742A>G	ENST00000287748.3	-	2	277	c.2T>C	c.(1-3)aTg>aCg	p.M1T	LYZL4_ENST00000470991.1_Intron|LYZL4_ENST00000441172.1_Start_Codon_SNP_p.M1T	NM_144634.2	NP_653235.1	Q96KX0	LYZL4_HUMAN	lysozyme-like 4	1					cell wall macromolecule catabolic process	extracellular region	lysozyme activity			central_nervous_system(1)|endometrium(1)|lung(1)	3				KIRC - Kidney renal clear cell carcinoma(284;0.222)		GGATGCCTTCATCTTCTCCAG	0.572000													5	59					0	0	1	0	0
ANKRD36C	400986	broad.mit.edu	37	2	96593000	96593000	+	Missense_Mutation	SNP	A	A	G	rs111976783		TCGA-TQ-A7RQ-01A-11D-A33T-08	TCGA-TQ-A7RQ-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	adbae2bb-eb36-44ff-ad9e-1aa089cff90b	aa8b45fd-3ac5-45c8-a77a-ea08fc5c0654	g.chr2:96593000A>G	ENST00000456556.1	-	28	1985	c.1901T>C	c.(1900-1902)aTa>aCa	p.I634T						ankyrin repeat domain 36C									p.I634T(1)		breast(1)|endometrium(8)|kidney(5)|lung(4)	18						TTCTGTGGCTATATTTGAAAC	0.338000													5	141					0	0	1	0	0
ITIH6	347365	broad.mit.edu	37	X	54783460	54783460	+	Missense_Mutation	SNP	G	G	A			TCGA-TQ-A7RQ-01A-11D-A33T-08	TCGA-TQ-A7RQ-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	adbae2bb-eb36-44ff-ad9e-1aa089cff90b	aa8b45fd-3ac5-45c8-a77a-ea08fc5c0654	g.chrX:54783460G>A	ENST00000218436.6	-	8	3076	c.3047C>T	c.(3046-3048)tCc>tTc	p.S1016F		NM_198510.2	NP_940912.1	Q6UXX5	ITH5L_HUMAN	inter-alpha-trypsin inhibitor heavy chain family, member 6	1016					hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity										CACGAACTTGGATTCCACCAT	0.527000													9	52					0	0	1	0	0
GGT3P	0	broad.mit.edu	37	22	18778610	18778610	+	RNA	SNP	G	G	A			TCGA-TQ-A7RQ-01A-11D-A33T-08	TCGA-TQ-A7RQ-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	adbae2bb-eb36-44ff-ad9e-1aa089cff90b	aa8b45fd-3ac5-45c8-a77a-ea08fc5c0654	g.chr22:18778610G>A	ENST00000412448.1	-	0	795																											CCGCGGCCACGGCAGCCCTGG	0.632000													8	12					0	0	1	0	0
RNF135	84282	broad.mit.edu	37	17	29325786	29325786	+	Nonsense_Mutation	SNP	G	G	A			TCGA-TQ-A7RQ-01A-11D-A33T-08	TCGA-TQ-A7RQ-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	adbae2bb-eb36-44ff-ad9e-1aa089cff90b	aa8b45fd-3ac5-45c8-a77a-ea08fc5c0654	g.chr17:29325786G>A	ENST00000328381.5	+	5	1749	c.876G>A	c.(874-876)tgG>tgA	p.W292*	RNF135_ENST00000535306.2_3'UTR|RNF135_ENST00000324689.4_3'UTR|RNF135_ENST00000443677.2_3'UTR	NM_032322.3	NP_115698.3	Q8IUD6	RN135_HUMAN	ring finger protein 135	292	B30.2/SPRY.				innate immune response|negative regulation of type I interferon production|positive regulation of interferon-beta production|regulation of innate immune response	cytosol	protein binding|ribonucleoprotein binding|ubiquitin-protein ligase activity|zinc ion binding	p.?(1)		breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(2)|lung(1)|skin(2)|urinary_tract(1)	10		all_cancers(10;8.65e-08)|all_hematologic(16;0.00556)|Acute lymphoblastic leukemia(14;0.00593)|Myeloproliferative disorder(56;0.0255)				CCTATCGCTGGAGCTGTGAGA	0.532000													8	129					0	0	1	0	0
ITPR3	3710	broad.mit.edu	37	6	33656147	33656147	+	Silent	SNP	C	C	T			TCGA-TQ-A7RQ-01A-11D-A33T-08	TCGA-TQ-A7RQ-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	adbae2bb-eb36-44ff-ad9e-1aa089cff90b	aa8b45fd-3ac5-45c8-a77a-ea08fc5c0654	g.chr6:33656147C>T	ENST00000374316.5	+	49	7567	c.6507C>T	c.(6505-6507)agC>agT	p.S2169S	ITPR3_ENST00000605930.1_Silent_p.S2169S			Q14573	ITPR3_HUMAN	inositol 1,4,5-trisphosphate receptor, type 3	2169					activation of phospholipase C activity|calcium ion transport into cytosol|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|nerve growth factor receptor signaling pathway|platelet activation|protein heterooligomerization|protein homooligomerization|regulation of insulin secretion|response to calcium ion	apical part of cell|brush border|endoplasmic reticulum membrane|integral to plasma membrane|myelin sheath|neuronal cell body|nuclear outer membrane|platelet dense tubular network membrane	inositol 1,3,4,5 tetrakisphosphate binding|inositol 1,4,5 trisphosphate binding|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|inositol hexakisphosphate binding|intracellular ligand-gated calcium channel activity|protein binding			NS(1)|breast(6)|central_nervous_system(5)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|liver(1)|lung(24)|ovary(8)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	85						GCAAAGTGAGCGACTTCTTCG	0.632000													8	87					0	0	1	0	0
ARHGAP39	80728	broad.mit.edu	37	8	145763155	145763155	+	Missense_Mutation	SNP	T	T	C			TCGA-TQ-A7RQ-01A-11D-A33T-08	TCGA-TQ-A7RQ-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	adbae2bb-eb36-44ff-ad9e-1aa089cff90b	aa8b45fd-3ac5-45c8-a77a-ea08fc5c0654	g.chr8:145763155T>C	ENST00000377307.2	-	6	2648	c.2564A>G	c.(2563-2565)aAg>aGg	p.K855R	ARHGAP39_ENST00000528810.1_5'UTR|ARHGAP39_ENST00000276826.5_Intron|ARHGAP39_ENST00000540274.1_Intron	NM_025251.1	NP_079527.1	Q9C0H5	RHG39_HUMAN	Rho GTPase activating protein 39	840	MyTH4.				axon guidance|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytoskeleton|cytosol|nucleus	GTPase activator activity			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(11)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	22						TTTGGACTTCTTCTTAGTGTT	0.547000													68	194					0	0	1	0	0
DENND4B	9909	broad.mit.edu	37	1	153907309	153907309	+	Silent	SNP	C	C	T			TCGA-TQ-A7RQ-01A-11D-A33T-08	TCGA-TQ-A7RQ-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	adbae2bb-eb36-44ff-ad9e-1aa089cff90b	aa8b45fd-3ac5-45c8-a77a-ea08fc5c0654	g.chr1:153907309C>T	ENST00000361217.4	-	18	3118	c.2700G>A	c.(2698-2700)caG>caA	p.Q900Q		NM_014856.2	NP_055671.2	O75064	DEN4B_HUMAN	DENN/MADD domain containing 4B	900	Gln-rich.							p.Q788Q(1)|p.Q900Q(1)		NS(1)|breast(1)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(6)|lung(9)|ovary(1)|prostate(5)|skin(2)|urinary_tract(1)	36	all_lung(78;2.89e-32)|Lung NSC(65;2.27e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)			gctgctgttgctgctgctgct	0.642000													4	116					0	0	1	0	0
IL1RAPL2	26280	broad.mit.edu	37	X	104984645	104984645	+	Missense_Mutation	SNP	A	A	C			TCGA-TQ-A7RQ-01A-11D-A33T-08	TCGA-TQ-A7RQ-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	adbae2bb-eb36-44ff-ad9e-1aa089cff90b	aa8b45fd-3ac5-45c8-a77a-ea08fc5c0654	g.chrX:104984645A>C	ENST00000372582.1	+	8	1765	c.1009A>C	c.(1009-1011)Aat>Cat	p.N337H	IL1RAPL2_ENST00000344799.4_Missense_Mutation_p.N337H|IL1RAPL2_ENST00000485671.1_3'UTR	NM_017416.1	NP_059112.1	Q9NP60	IRPL2_HUMAN	interleukin 1 receptor accessory protein-like 2	337	Ig-like C2-type 3.				central nervous system development|innate immune response	integral to membrane	interleukin-1, Type II, blocking receptor activity			breast(3)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(14)|lung(23)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	49						TGAAAACCGAAATGGACGGAA	0.378000													14	193					0	0	1	0	0
FLNC	2318	broad.mit.edu	37	7	128478760	128478760	+	Silent	SNP	C	C	T			TCGA-TQ-A7RQ-01A-11D-A33T-08	TCGA-TQ-A7RQ-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	adbae2bb-eb36-44ff-ad9e-1aa089cff90b	aa8b45fd-3ac5-45c8-a77a-ea08fc5c0654	g.chr7:128478760C>T	ENST00000325888.8	+	8	1575	c.1314C>T	c.(1312-1314)tgC>tgT	p.C438C	FLNC_ENST00000346177.6_Silent_p.C438C	NM_001458.4	NP_001449.3	Q14315	FLNC_HUMAN	filamin C, gamma	438					cell junction assembly	cytoskeleton|cytosol|plasma membrane|sarcomere	actin binding			biliary_tract(1)|breast(7)|central_nervous_system(1)|cervix(1)|endometrium(19)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(19)|lung(59)|ovary(2)|pancreas(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)	128						CGTTCCGCTGCACATACAGAC	0.642000													9	236					0	0	1	0	0
RNPEP	6051	broad.mit.edu	37	1	201958650	201958650	+	Missense_Mutation	SNP	T	T	C			TCGA-TQ-A7RQ-01A-11D-A33T-08	TCGA-TQ-A7RQ-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	adbae2bb-eb36-44ff-ad9e-1aa089cff90b	aa8b45fd-3ac5-45c8-a77a-ea08fc5c0654	g.chr1:201958650T>C	ENST00000295640.4	+	3	771	c.728T>C	c.(727-729)gTt>gCt	p.V243A	RNPEP_ENST00000367286.3_Missense_Mutation_p.V243A|RNPEP_ENST00000471105.1_Intron	NM_020216.3	NP_064601.3	Q9H4A4	AMPB_HUMAN	arginyl aminopeptidase (aminopeptidase B)	243					leukotriene biosynthetic process		epoxide hydrolase activity|zinc ion binding			breast(1)|endometrium(4)|large_intestine(4)|lung(6)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	21				KIRC - Kidney renal clear cell carcinoma(1967;3.23e-08)|Colorectal(1306;0.005)		TCGGCTGAAGTTGGACCCAGG	0.552000													11	126					0	0	1	0	0
GRIN2A	0	broad.mit.edu	37	16	9858656	9858656	+	Missense_Mutation	SNP	C	C	A			TCGA-TQ-A7RQ-01A-11D-A33T-08	TCGA-TQ-A7RQ-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	adbae2bb-eb36-44ff-ad9e-1aa089cff90b	aa8b45fd-3ac5-45c8-a77a-ea08fc5c0654	g.chr16:9858656C>A	ENST00000396573.2	-	14	3054	c.2745G>T	c.(2743-2745)atG>atT	p.M915I	GRIN2A_ENST00000396575.2_Missense_Mutation_p.M915I|GRIN2A_ENST00000330684.3_Missense_Mutation_p.M915I|GRIN2A_ENST00000535259.1_Missense_Mutation_p.M758I|GRIN2A_ENST00000404927.2_Missense_Mutation_p.M915I|GRIN2A_ENST00000562109.1_Missense_Mutation_p.M915I	NM_000833.3	NP_000824.1	Q12879	NMDE1_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 2A	915					response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			NS(7)|breast(5)|cervix(1)|endometrium(11)|kidney(6)|large_intestine(36)|lung(71)|ovary(4)|prostate(9)|skin(45)|upper_aerodigestive_tract(2)|urinary_tract(1)	198					Felbamate(DB00949)|Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	TGGGTGAGTCCATTCTTGAGG	0.463000													6	408					6.5536e-12	7.51479e-12	1	1	0
ITPK1	3705	broad.mit.edu	37	14	93483148	93483148	+	Splice_Site	SNP	T	T	C			TCGA-TQ-A7RQ-01A-11D-A33T-08	TCGA-TQ-A7RQ-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	adbae2bb-eb36-44ff-ad9e-1aa089cff90b	aa8b45fd-3ac5-45c8-a77a-ea08fc5c0654	g.chr14:93483148T>C	ENST00000267615.6	-	4	294		c.e4-2		ITPK1_ENST00000556954.1_Splice_Site|ITPK1_ENST00000354313.3_Splice_Site|ITPK1_ENST00000555495.1_Splice_Site|ITPK1_ENST00000556603.2_Splice_Site			Q13572	ITPK1_HUMAN	inositol-tetrakisphosphate 1-kinase						blood coagulation|inositol trisphosphate metabolic process|signal transduction	cytosol	ATP binding|hydrolase activity|inositol tetrakisphosphate 1-kinase activity|inositol-1,3,4-trisphosphate 5/6-kinase activity|isomerase activity|ligase activity|magnesium ion binding	p.?(2)		endometrium(1)|large_intestine(3)|lung(6)|ovary(1)	11		all_cancers(154;0.077)|all_epithelial(191;0.247)		Epithelial(152;0.124)|all cancers(159;0.169)		AAGGTTCAGCTGTGAGGCAGG	0.577000													27	57					0	0	1	0	0
RYR3	6263	broad.mit.edu	37	15	33840366	33840366	+	Missense_Mutation	SNP	G	G	A			TCGA-TQ-A7RQ-01A-11D-A33T-08	TCGA-TQ-A7RQ-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	adbae2bb-eb36-44ff-ad9e-1aa089cff90b	aa8b45fd-3ac5-45c8-a77a-ea08fc5c0654	g.chr15:33840366G>A	ENST00000389232.4	+	9	846	c.776G>A	c.(775-777)cGa>cAa	p.R259Q	RYR3_ENST00000415757.3_Missense_Mutation_p.R259Q	NM_001036.3	NP_001027.3	Q15413	RYR3_HUMAN	ryanodine receptor 3	259	MIR 3.				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(3)|breast(9)|central_nervous_system(8)|cervix(2)|endometrium(29)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(55)|lung(148)|ovary(7)|pancreas(1)|prostate(13)|skin(4)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(3)	311		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		GCTGGGACTCGAGCCAGGTCT	0.512000													4	25					0	0	1	0	0
ADAR	103	broad.mit.edu	37	1	154600401	154600401	+	Missense_Mutation	SNP	A	A	C			TCGA-TQ-A7RQ-01A-11D-A33T-08	TCGA-TQ-A7RQ-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	adbae2bb-eb36-44ff-ad9e-1aa089cff90b	aa8b45fd-3ac5-45c8-a77a-ea08fc5c0654	g.chr1:154600401A>C	ENST00000292205.5	-	1	73	c.74T>G	c.(73-75)gTg>gGg	p.V25G	ADAR_ENST00000368471.3_5'UTR|ADAR_ENST00000471068.1_Intron	NM_001025107.2|NM_001193495.1	NP_001020278.1|NP_001180424.1	P55265	DSRAD_HUMAN	adenosine deaminase, RNA-specific	0					adenosine to inosine editing|gene silencing by RNA|mRNA modification|mRNA processing|type I interferon-mediated signaling pathway	cytoplasm|nucleolus|nucleoplasm	DNA binding|double-stranded RNA adenosine deaminase activity|metal ion binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(9)|lung(20)|ovary(4)|prostate(2)|skin(2)	51	all_lung(78;2.22e-29)|Lung NSC(65;3.66e-27)|all_hematologic(923;0.088)|Hepatocellular(266;0.0997)		LUSC - Lung squamous cell carcinoma(543;0.185)	Colorectal(1306;0.115)		CCCTCCCCCCACCCTCCCCCA	0.642000													9	58					0	0	1	0	0
DOCK6	57572	broad.mit.edu	37	19	11352784	11352784	+	Missense_Mutation	SNP	C	C	T			TCGA-TQ-A7RQ-01A-11D-A33T-08	TCGA-TQ-A7RQ-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	adbae2bb-eb36-44ff-ad9e-1aa089cff90b	aa8b45fd-3ac5-45c8-a77a-ea08fc5c0654	g.chr19:11352784C>T	ENST00000294618.7	-	14	1591	c.1580G>A	c.(1579-1581)cGg>cAg	p.R527Q		NM_020812.3	NP_065863.2	Q96HP0	DOCK6_HUMAN	dedicator of cytokinesis 6	527					blood coagulation	cytosol	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			breast(1)|central_nervous_system(1)|endometrium(11)|large_intestine(8)|liver(2)|lung(9)|ovary(4)|prostate(1)|skin(1)|urinary_tract(1)	39						CTTGGTGGGCCGGCCCCTGGG	0.622000													3	36					0	0	1	0	0
SPINK9	643394	broad.mit.edu	37	5	147715192	147715192	+	Missense_Mutation	SNP	A	A	G			TCGA-TQ-A7RQ-01A-11D-A33T-08	TCGA-TQ-A7RQ-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	adbae2bb-eb36-44ff-ad9e-1aa089cff90b	aa8b45fd-3ac5-45c8-a77a-ea08fc5c0654	g.chr5:147715192A>G	ENST00000377906.1	+	1	71	c.16A>G	c.(16-18)Ata>Gta	p.I6V	RP11-373N22.3_ENST00000501695.3_RNA|SPINK9_ENST00000511717.2_Intron	NM_001040433.1	NP_001035523.1	Q5DT21	ISK9_HUMAN	serine peptidase inhibitor, Kazal type 9	6						extracellular region	protein binding|serine-type endopeptidase inhibitor activity			ovary(1)|urinary_tract(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGCAACAGCCATAGTCCTACT	0.478000													5	146					0	0	1	0	0
SLC12A2	6558	broad.mit.edu	37	5	127520188	127520188	+	Missense_Mutation	SNP	A	A	C			TCGA-TQ-A7RQ-01A-11D-A33T-08	TCGA-TQ-A7RQ-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	adbae2bb-eb36-44ff-ad9e-1aa089cff90b	aa8b45fd-3ac5-45c8-a77a-ea08fc5c0654	g.chr5:127520188A>C	ENST00000262461.2	+	25	3619	c.3430A>C	c.(3430-3432)Acc>Ccc	p.T1144P	SLC12A2_ENST00000507791.1_3'UTR|SLC12A2_ENST00000343225.4_Missense_Mutation_p.T1128P	NM_001046.2	NP_001037.1	P55011	S12A2_HUMAN	solute carrier family 12 (sodium/potassium/chloride transporter), member 2	1144					potassium ion transport|sodium ion transport|transepithelial ammonium transport|transepithelial chloride transport	integral to plasma membrane|membrane fraction	ammonia transmembrane transporter activity|sodium:potassium:chloride symporter activity			breast(3)|endometrium(5)|kidney(5)|large_intestine(12)|lung(16)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	48		all_cancers(142;0.0972)|Prostate(80;0.151)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	Epithelial(69;0.0433)|OV - Ovarian serous cystadenocarcinoma(64;0.0978)	Bumetanide(DB00887)|Potassium Chloride(DB00761)	ACTTTATAAGACCAAGGTATT	0.303000													11	160					0	0	1	0	0
BCOR	54880	broad.mit.edu	37	X	39922919	39922919	+	Missense_Mutation	SNP	C	C	A			TCGA-TQ-A7RQ-01A-11D-A33T-08	TCGA-TQ-A7RQ-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	adbae2bb-eb36-44ff-ad9e-1aa089cff90b	aa8b45fd-3ac5-45c8-a77a-ea08fc5c0654	g.chrX:39922919C>A	ENST00000342274.4	-	8	4049	c.3687G>T	c.(3685-3687)gaG>gaT	p.E1229D	BCOR_ENST00000397354.3_Missense_Mutation_p.E1229D|BCOR_ENST00000378444.4_Missense_Mutation_p.E1263D|BCOR_ENST00000378463.1_Missense_Mutation_p.E106D|BCOR_ENST00000378455.4_Missense_Mutation_p.E1211D	NM_001123383.1	NP_001116855.1	Q6W2J9	BCOR_HUMAN	BCL6 corepressor	1263					heart development|histone H2A monoubiquitination|negative regulation of bone mineralization|negative regulation of histone H3-K36 methylation|negative regulation of histone H3-K4 methylation|negative regulation of tooth mineralization|negative regulation of transcription from RNA polymerase II promoter|odontogenesis|palate development|specification of axis polarity|transcription, DNA-dependent	nucleus	heat shock protein binding|histone deacetylase binding|transcription corepressor activity|transcription factor binding|transcription regulatory region DNA binding			breast(4)|central_nervous_system(11)|cervix(1)|endometrium(24)|eye(6)|haematopoietic_and_lymphoid_tissue(33)|kidney(2)|large_intestine(11)|lung(22)|ovary(2)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	126						TGCCTTTGGCCTCTGCCCTTT	0.567000			"""F, N, S, T"""	RARA	"""retinoblastoma, AML, APL(translocation)"""		oculo-facio-cardio-dental genetic						145	198					1.81449e-70	2.10874e-70	1	1	0
HSCB	150274	broad.mit.edu	37	22	29138096	29138096	+	Missense_Mutation	SNP	A	A	G			TCGA-TQ-A7RQ-01A-11D-A33T-08	TCGA-TQ-A7RQ-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	adbae2bb-eb36-44ff-ad9e-1aa089cff90b	aa8b45fd-3ac5-45c8-a77a-ea08fc5c0654	g.chr22:29138096A>G	ENST00000216027.3	+	1	78	c.13A>G	c.(13-15)Aga>Gga	p.R5G	HSCB_ENST00000398941.2_Missense_Mutation_p.R5G|CHEK2_ENST00000544772.1_5'UTR	NM_172002.3	NP_741999.3	Q8IWL3	HSC20_HUMAN	HscB mitochondrial iron-sulfur cluster co-chaperone	5					iron-sulfur cluster assembly|protein folding	mitochondrion	chaperone binding|heat shock protein binding|metal ion binding			kidney(1)|lung(2)|skin(1)	4						GTGGCGGGGGAGAGCCGGGGC	0.612000													7	16					0	0	1	0	0
CREBZF	58487	broad.mit.edu	37	11	85375402	85375402	+	Missense_Mutation	SNP	C	C	A			TCGA-TQ-A7RQ-01A-11D-A33T-08	TCGA-TQ-A7RQ-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	adbae2bb-eb36-44ff-ad9e-1aa089cff90b	aa8b45fd-3ac5-45c8-a77a-ea08fc5c0654	g.chr11:85375402C>A	ENST00000527447.1	-	1	744	c.518G>T	c.(517-519)tGc>tTc	p.C173F	CREBZF_ENST00000398294.2_Missense_Mutation_p.C91F|CREBZF_ENST00000534224.1_Intron|CREBZF_ENST00000531515.1_Intron	NM_001039618.2	NP_001034707.1	Q9NS37	ZHANG_HUMAN	CREB/ATF bZIP transcription factor	173					negative regulation of gene expression, epigenetic|negative regulation of transcription, DNA-dependent|regulation of sequence-specific DNA binding transcription factor activity|response to virus	nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			cervix(1)|endometrium(1)|kidney(1)|large_intestine(3)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	9		Acute lymphoblastic leukemia(157;4.19e-06)|all_hematologic(158;0.0033)				gctgctgctgcagcctccgat	0.642000											OREG0021274	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	3	49					1	1	1	1	0
OSBPL5	114879	broad.mit.edu	37	11	3128640	3128640	+	Silent	SNP	C	C	T			TCGA-TQ-A7RQ-01A-11D-A33T-08	TCGA-TQ-A7RQ-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	adbae2bb-eb36-44ff-ad9e-1aa089cff90b	aa8b45fd-3ac5-45c8-a77a-ea08fc5c0654	g.chr11:3128640C>T	ENST00000263650.7	-	9	1071	c.912G>A	c.(910-912)tcG>tcA	p.S304S	OSBPL5_ENST00000389989.3_Silent_p.S236S|OSBPL5_ENST00000525498.1_Silent_p.S215S|OSBPL5_ENST00000542243.1_Intron|OSBPL5_ENST00000348039.5_Silent_p.S236S	NM_020896.3	NP_065947.1	Q9H0X9	OSBL5_HUMAN	oxysterol binding protein-like 5	304					cholesterol metabolic process|cholesterol transport|Golgi to plasma membrane transport	cytosol	oxysterol binding|protein binding			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(7)|lung(8)|prostate(1)|upper_aerodigestive_tract(1)	25		all_epithelial(84;0.000236)|Medulloblastoma(188;0.00106)|Breast(177;0.00328)|Ovarian(85;0.00556)|all_neural(188;0.00681)		BRCA - Breast invasive adenocarcinoma(625;0.00607)|LUSC - Lung squamous cell carcinoma(625;0.207)		TCTCTCTCTCCGACTTGTCTG	0.612000													6	320					0	0	1	0	0
CFHR5	81494	broad.mit.edu	37	1	196971684	196971684	+	Missense_Mutation	SNP	A	A	T			TCGA-TQ-A7RQ-01A-11D-A33T-08	TCGA-TQ-A7RQ-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	adbae2bb-eb36-44ff-ad9e-1aa089cff90b	aa8b45fd-3ac5-45c8-a77a-ea08fc5c0654	g.chr1:196971684A>T	ENST00000367414.5	+	8	1348	c.1292A>T	c.(1291-1293)tAt>tTt	p.Y431F	CFHR5_ENST00000256785.4_Missense_Mutation_p.Y407F	NM_030787.3	NP_110414.1	Q9BXR6	FHR5_HUMAN	complement factor H-related 5	407	Sushi 7.				complement activation, alternative pathway	extracellular region				NS(2)|breast(2)|endometrium(2)|kidney(1)|large_intestine(7)|liver(2)|lung(23)|pancreas(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)	49						ACAGTGAATTATCAGGATGGA	0.358000													4	109					0	0	1	0	0
WNK3	65267	broad.mit.edu	37	X	54324778	54324778	+	Nonsense_Mutation	SNP	C	C	A			TCGA-TQ-A7RQ-01A-11D-A33T-08	TCGA-TQ-A7RQ-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	adbae2bb-eb36-44ff-ad9e-1aa089cff90b	aa8b45fd-3ac5-45c8-a77a-ea08fc5c0654	g.chrX:54324778C>A	ENST00000354646.2	-	7	1666	c.1228G>T	c.(1228-1230)Gga>Tga	p.G410*	WNK3_ENST00000375159.2_Nonsense_Mutation_p.G410*|WNK3_ENST00000375169.3_Nonsense_Mutation_p.G410*	NM_020922.4	NP_065973.2	Q9BYP7	WNK3_HUMAN	WNK lysine deficient protein kinase 3	410					intracellular protein kinase cascade|positive regulation of establishment of protein localization in plasma membrane|positive regulation of peptidyl-threonine phosphorylation|positive regulation of rubidium ion transmembrane transporter activity|positive regulation of rubidium ion transport|positive regulation of sodium ion transmembrane transporter activity|positive regulation of sodium ion transport|protein autophosphorylation	adherens junction|tight junction	ATP binding|protein binding|protein serine/threonine kinase activity|rubidium ion transmembrane transporter activity|sodium ion transmembrane transporter activity			autonomic_ganglia(1)|biliary_tract(1)|breast(4)|central_nervous_system(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|lung(24)|ovary(4)|pancreas(2)|prostate(4)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	80						ACCCTCAGTCCTGTATCCTCA	0.373000													4	183					0.000602214	0.000655575	1	1	0
AFTPH	54812	broad.mit.edu	37	2	64778672	64778674	+	In_Frame_Del	DEL	GAT	GAT	-			TCGA-TQ-A7RQ-01A-11D-A33T-08	TCGA-TQ-A7RQ-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	adbae2bb-eb36-44ff-ad9e-1aa089cff90b	aa8b45fd-3ac5-45c8-a77a-ea08fc5c0654	g.chr2:64778672_64778674delGAT	ENST00000422803.1	+	2	378_380	c.64_66delGAT	c.(64-66)del	p.D26del	AFTPH_ENST00000409933.1_In_Frame_Del_p.D26del|AFTPH_ENST00000238855.7_In_Frame_Del_p.D26del|AFTPH_ENST00000238856.4_In_Frame_Del_p.D26del			Q6ULP2	AFTIN_HUMAN	aftiphilin	26					protein transport	AP-1 adaptor complex|cytosol|nucleus	clathrin binding			breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(11)|ovary(2)|prostate(1)|skin(3)|urinary_tract(1)	35						TGGAGCAGAGGATGATGATGATG	0.409													8	304	---	---	---	---					
MCC	4163	broad.mit.edu	37	5	112824048	112824049	+	In_Frame_Ins	INS	-	-	GCC	rs35336557		TCGA-TQ-A7RQ-01A-11D-A33T-08	TCGA-TQ-A7RQ-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	adbae2bb-eb36-44ff-ad9e-1aa089cff90b	aa8b45fd-3ac5-45c8-a77a-ea08fc5c0654	g.chr5:112824048_112824049insGCC	ENST00000408903.3	-	1	478_479	c.63_64insGGC	c.(61-66)gggcgg>ggGGCgcgg	p.21_22GR>GAR		NM_001085377.1	NP_001078846.1	P23508	CRCM_HUMAN	mutated in colorectal cancers	549					negative regulation of canonical Wnt receptor signaling pathway|negative regulation of epithelial cell migration|negative regulation of epithelial cell proliferation|Wnt receptor signaling pathway	cytoplasm|nucleus|plasma membrane	protein binding|receptor activity			endometrium(4)|kidney(3)|large_intestine(15)|liver(2)|lung(8)|ovary(2)|pancreas(1)|prostate(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	42		all_cancers(142;5.89e-08)|all_epithelial(76;3.57e-11)|all_lung(232;0.000605)|Lung NSC(810;0.000697)|Colorectal(10;0.00146)|Prostate(80;0.00174)|Ovarian(225;0.0175)|Breast(839;0.198)		OV - Ovarian serous cystadenocarcinoma(64;2.04e-54)|Epithelial(69;9.69e-49)|all cancers(49;6.25e-44)|COAD - Colon adenocarcinoma(37;0.0432)|Colorectal(14;0.0766)		ctgctgccgctgccgccgccgc	0.738													7	25	---	---	---	---					
ZNF292	23036	broad.mit.edu	37	6	87968903	87968903	+	Frame_Shift_Del	DEL	C	C	-			TCGA-TQ-A7RQ-01A-11D-A33T-08	TCGA-TQ-A7RQ-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	adbae2bb-eb36-44ff-ad9e-1aa089cff90b	aa8b45fd-3ac5-45c8-a77a-ea08fc5c0654	g.chr6:87968903delC	ENST00000369577.3	+	8	5599	c.5556delC	c.(5554-5556)gafs	p.D1852fs	ZNF292_ENST00000339907.4_Frame_Shift_Del_p.D1847fs	NM_015021.1	NP_055836.1	O60281	ZN292_HUMAN	zinc finger protein 292	1852					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(27)|lung(21)|ovary(4)|prostate(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	89		all_cancers(76;3.82e-09)|Prostate(29;1.34e-10)|Acute lymphoblastic leukemia(125;2.17e-10)|all_hematologic(105;1.08e-06)|all_epithelial(107;5.31e-05)		BRCA - Breast invasive adenocarcinoma(108;0.0199)		TAGAAAATGACCTATCCACTC	0.378													51	87	---	---	---	---					
TRBV7-3	0	broad.mit.edu	37	7	142247473	142247474	+	RNA	DEL	AT	AT	-	rs150154096	by1000genomes	TCGA-TQ-A7RQ-01A-11D-A33T-08	TCGA-TQ-A7RQ-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	adbae2bb-eb36-44ff-ad9e-1aa089cff90b	aa8b45fd-3ac5-45c8-a77a-ea08fc5c0654	g.chr7:142247473_142247474delAT	ENST00000390361.3	-	0	99																											acacacacacatacagacacac	0.559													7	296	---	---	---	---					
WRN	7486	broad.mit.edu	37	8	30945377	30945379	+	In_Frame_Del	DEL	AAG	AAG	-			TCGA-TQ-A7RQ-01A-11D-A33T-08	TCGA-TQ-A7RQ-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	adbae2bb-eb36-44ff-ad9e-1aa089cff90b	aa8b45fd-3ac5-45c8-a77a-ea08fc5c0654	g.chr8:30945377_30945379delAAG	ENST00000298139.5	+	12	1766_1768	c.1517_1519delAAG	c.(1516-1521)aaa>a	p.KE506del		NM_000553.4	NP_000544.2	Q14191	WRN_HUMAN	Werner syndrome, RecQ helicase-like	506					base-excision repair|cellular response to starvation|DNA recombination|DNA synthesis involved in DNA repair|multicellular organismal aging|nucleolus to nucleoplasm transport|positive regulation of hydrolase activity|regulation of apoptosis|replication fork processing|response to oxidative stress|response to UV-C|telomere maintenance	centrosome|nucleolus|nucleoplasm	3'-5' exonuclease activity|ATP binding|ATP-dependent 3'-5' DNA helicase activity|bubble DNA binding|four-way junction helicase activity|G-quadruplex DNA binding|magnesium ion binding|manganese ion binding|protein complex binding|protein homodimerization activity|Y-form DNA binding			central_nervous_system(2)|endometrium(4)|kidney(4)|large_intestine(13)|lung(28)|ovary(3)|skin(3)|upper_aerodigestive_tract(3)	60		Breast(100;0.195)		KIRC - Kidney renal clear cell carcinoma(542;0.147)|Kidney(114;0.176)|Colorectal(111;0.192)		CTTCCTACTAaagaagaagaaga	0.360			"""Mis, N, F, S"""			"""osteosarcoma, meningioma, others"""		Genes defective in diseases associated with sensitivity to DNA damaging agents	Werner syndrome				7	266	---	---	---	---					
IGHJ6	0	broad.mit.edu	37	14	106329450	106329451	+	RNA	INS	-	-	ACC	rs74454466	by1000genomes	TCGA-TQ-A7RQ-01A-11D-A33T-08	TCGA-TQ-A7RQ-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	adbae2bb-eb36-44ff-ad9e-1aa089cff90b	aa8b45fd-3ac5-45c8-a77a-ea08fc5c0654	g.chr14:106329450_106329451insACC	ENST00000390560.2	-	0	17_18																											CAGACGTCCATGTAGTAGTAGT	0.540													7	116	---	---	---	---					
CIC	23152	broad.mit.edu	37	19	42795426	42795450	+	Frame_Shift_Del	DEL	CTTCAGGTGGCACCTGCCCCAGCAC	CTTCAGGTGGCACCTGCCCCAGCAC	-			TCGA-TQ-A7RQ-01A-11D-A33T-08	TCGA-TQ-A7RQ-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	adbae2bb-eb36-44ff-ad9e-1aa089cff90b	aa8b45fd-3ac5-45c8-a77a-ea08fc5c0654	g.chr19:42795426_42795450delCTTCAGGTGGCACCTGCCCCAGCAC	ENST00000572681.2	+	11	5301_5325	c.5233_5257delCTTCAGGTGGCACCTGCCCCAGCAC	c.(5233-5259)cafs	p.LQVAPAPAP1745fs	CIC_ENST00000575354.2_Frame_Shift_Del_p.LQVAPAPAP836fs|CIC_ENST00000160740.3_Frame_Shift_Del_p.LQVAPAPAP836fs			Q96RK0	CIC_HUMAN	capicua transcriptional repressor	836					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding			autonomic_ganglia(1)|breast(5)|central_nervous_system(32)|endometrium(10)|kidney(2)|large_intestine(7)|lung(9)|ovary(7)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	82		Prostate(69;0.00682)				GCCCCAGCAGCTTCAGGTGGCACCTGCCCCAGCACCAGCCCCTGG	0.667			"""Mis, F, S"""		oligodendroglioma								18	11	---	---	---	---					
ANKRD20A11P	0	broad.mit.edu	37	21	15343608	15343609	+	RNA	INS	-	-	A			TCGA-TQ-A7RQ-01A-11D-A33T-08	TCGA-TQ-A7RQ-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	adbae2bb-eb36-44ff-ad9e-1aa089cff90b	aa8b45fd-3ac5-45c8-a77a-ea08fc5c0654	g.chr21:15343608_15343609insA	ENST00000344693.5	-	0	736					NR_027270.1																						TAAAACAGCAGAAAAAATTAAT	0.272													9	269	---	---	---	---					
MAGEC1	9947	broad.mit.edu	37	X	140994639	140994641	+	In_Frame_Del	DEL	CTC	CTC	-	rs144357389	byFrequency	TCGA-TQ-A7RQ-01A-11D-A33T-08	TCGA-TQ-A7RQ-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	adbae2bb-eb36-44ff-ad9e-1aa089cff90b	aa8b45fd-3ac5-45c8-a77a-ea08fc5c0654	g.chrX:140994639_140994641delCTC	ENST00000285879.4	+	4	1735_1737	c.1449_1451delCTC	c.(1447-1452)agc>ag	p.SS487del	MAGEC1_ENST00000406005.2_Intron	NM_005462.4	NP_005453.2	O60732	MAGC1_HUMAN	melanoma antigen family C, 1	487							protein binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(22)|lung(60)|ovary(1)|pancreas(1)|prostate(1)|skin(7)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(1)	127	Acute lymphoblastic leukemia(192;6.56e-05)					TTCCTGTGAGCTCCTCCTCCTCC	0.473										HNSCC(15;0.026)			9	573	---	---	---	---