Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
RP11-146E13.4	0	broad.mit.edu	37	14	19857036	19857036	+	RNA	SNP	A	A	G			TCGA-P5-A737-01A-11D-A32B-08	TCGA-P5-A737-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	936493de-1bf3-4ba3-8fd1-3365e35605c8	732b972d-1257-41a8-905a-7407e4a36995	g.chr14:19857036A>G	ENST00000548109.1	+	0	72																											CTGGATAATAAAGTTCATCTC	0.373000													3	56					0	0	1	0	0
ZFYVE1	53349	broad.mit.edu	37	14	73491039	73491039	+	Missense_Mutation	SNP	G	G	A			TCGA-P5-A737-01A-11D-A32B-08	TCGA-P5-A737-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	936493de-1bf3-4ba3-8fd1-3365e35605c8	732b972d-1257-41a8-905a-7407e4a36995	g.chr14:73491039G>A	ENST00000556143.1	-	2	898	c.178C>T	c.(178-180)Cgg>Tgg	p.R60W	ZFYVE1_ENST00000318876.5_Missense_Mutation_p.R60W|ZFYVE1_ENST00000553891.1_Missense_Mutation_p.R60W	NM_021260.2	NP_067083.1	Q9HBF4	ZFYV1_HUMAN	zinc finger, FYVE domain containing 1	60						endoplasmic reticulum|Golgi stack|perinuclear region of cytoplasm	1-phosphatidylinositol binding|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(6)|lung(17)|ovary(1)|prostate(2)|skin(1)	35		all_lung(585;1.33e-09)		OV - Ovarian serous cystadenocarcinoma(108;1.6e-46)|BRCA - Breast invasive adenocarcinoma(234;0.00349)		AGTCTTATCCGCTCATGGTTT	0.547000													4	110					0	0	1	0	0
ABCA13	154664	broad.mit.edu	37	7	48311922	48311922	+	Missense_Mutation	SNP	A	A	G			TCGA-P5-A737-01A-11D-A32B-08	TCGA-P5-A737-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	936493de-1bf3-4ba3-8fd1-3365e35605c8	732b972d-1257-41a8-905a-7407e4a36995	g.chr7:48311922A>G	ENST00000435803.1	+	17	2683	c.2659A>G	c.(2659-2661)Atg>Gtg	p.M887V		NM_152701.3	NP_689914.2	Q86UQ4	ABCAD_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 13	887					transport	integral to membrane	ATP binding|ATPase activity			breast(13)|central_nervous_system(8)|endometrium(25)|haematopoietic_and_lymphoid_tissue(4)|kidney(20)|large_intestine(51)|lung(100)|ovary(5)|pancreas(2)|prostate(22)|skin(10)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(4)	270						ATCACCAGCTATGAACATAGA	0.353000													34	54					0	0	1	0	0
OCA2	4948	broad.mit.edu	37	15	28202829	28202829	+	Silent	SNP	C	C	T			TCGA-P5-A737-01A-11D-A32B-08	TCGA-P5-A737-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	936493de-1bf3-4ba3-8fd1-3365e35605c8	732b972d-1257-41a8-905a-7407e4a36995	g.chr15:28202829C>T	ENST00000354638.3	-	16	1844	c.1689G>A	c.(1687-1689)ccG>ccA	p.P563P	OCA2_ENST00000353809.5_Silent_p.P539P|OCA2_ENST00000382996.2_Silent_p.P563P	NM_000275.2	NP_000266.2	Q04671	P_HUMAN	oculocutaneous albinism II	563					eye pigment biosynthetic process	endoplasmic reticulum membrane|endosome membrane|integral to membrane|lysosomal membrane|melanosome membrane	arsenite transmembrane transporter activity|citrate transmembrane transporter activity|L-tyrosine transmembrane transporter activity|protein binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(7)|kidney(3)|large_intestine(11)|lung(48)|ovary(4)|pancreas(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	85		all_lung(180;2.93e-12)|Breast(32;0.000315)|Colorectal(260;0.234)		all cancers(64;5.03e-07)|Epithelial(43;2.13e-06)|BRCA - Breast invasive adenocarcinoma(123;0.045)		CGCGGCTGGCCGGGCTGATGC	0.632000									Oculocutaneous Albinism				5	38					0	0	1	0	0
MAST4	375449	broad.mit.edu	37	5	66055567	66055567	+	Missense_Mutation	SNP	C	C	T			TCGA-P5-A737-01A-11D-A32B-08	TCGA-P5-A737-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	936493de-1bf3-4ba3-8fd1-3365e35605c8	732b972d-1257-41a8-905a-7407e4a36995	g.chr5:66055567C>T	ENST00000404260.3	+	2	702	c.394C>T	c.(394-396)Ccg>Tcg	p.P132S	MAST4_ENST00000406374.1_Missense_Mutation_p.P132S|MAST4_ENST00000406039.1_Missense_Mutation_p.P132S|MAST4_ENST00000403625.2_Missense_Mutation_p.P132S|MAST4_ENST00000478569.1_3'UTR			O15021	MAST4_HUMAN	microtubule associated serine/threonine kinase family member 4	132						cytoplasm	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(1)|kidney(2)|lung(6)|ovary(2)	13		Lung NSC(167;8.56e-06)|Prostate(74;0.00637)|Ovarian(174;0.0563)|Breast(144;0.0586)|Colorectal(97;0.245)		Lung(70;0.011)		TCCACCCATGCCGTTTCGGAA	0.488000													3	36					0	0	1	0	0
PRTG	283659	broad.mit.edu	37	15	55916585	55916585	+	Silent	SNP	T	T	C			TCGA-P5-A737-01A-11D-A32B-08	TCGA-P5-A737-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	936493de-1bf3-4ba3-8fd1-3365e35605c8	732b972d-1257-41a8-905a-7407e4a36995	g.chr15:55916585T>C	ENST00000389286.4	-	18	3095	c.3048A>G	c.(3046-3048)gaA>gaG	p.E1016E		NM_173814.4	NP_776175.2	Q2VWP7	PRTG_HUMAN	protogenin	1016					multicellular organismal development	integral to membrane				breast(1)|endometrium(6)|kidney(4)|large_intestine(7)|liver(1)|lung(18)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	41				all cancers(107;0.00891)|GBM - Glioblastoma multiforme(80;0.135)		GCATTAAAGATTCTTCATTTC	0.473000													3	84					0	0	1	0	0
MOV10L1	54456	broad.mit.edu	37	22	50591600	50591600	+	Missense_Mutation	SNP	G	G	C			TCGA-P5-A737-01A-11D-A32B-08	TCGA-P5-A737-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	936493de-1bf3-4ba3-8fd1-3365e35605c8	732b972d-1257-41a8-905a-7407e4a36995	g.chr22:50591600G>C	ENST00000262794.5	+	22	3102	c.3019G>C	c.(3019-3021)Gag>Cag	p.E1007Q	MOV10L1_ENST00000354853.2_Missense_Mutation_p.E50Q|MOV10L1_ENST00000395852.1_Missense_Mutation_p.E134Q|MOV10L1_ENST00000395843.1_Missense_Mutation_p.E50Q|MOV10L1_ENST00000395858.3_Missense_Mutation_p.E1007Q|MOV10L1_ENST00000545383.1_Missense_Mutation_p.E1007Q|MOV10L1_ENST00000540615.1_Missense_Mutation_p.E987Q	NM_018995.2	NP_061868.1	Q9BXT6	M10L1_HUMAN	Mov10l1, Moloney leukemia virus 10-like 1, homolog (mouse)	1007					germ cell development|multicellular organismal development|spermatogenesis		ATP binding|ATP-dependent RNA helicase activity|magnesium ion binding|RNA binding			breast(2)|endometrium(2)|kidney(5)|large_intestine(18)|lung(20)|ovary(3)|prostate(1)|skin(9)|stomach(4)|urinary_tract(3)	67		all_cancers(38;3.31e-11)|all_epithelial(38;5.69e-10)|all_lung(38;3.73e-05)|Breast(42;0.000525)|Lung NSC(38;0.000954)|Ovarian(80;0.0367)|Lung SC(80;0.114)		LUAD - Lung adenocarcinoma(64;0.0215)|BRCA - Breast invasive adenocarcinoma(115;0.24)		GCTGGGCTGGGAGAAGTTGCC	0.587000													46	42					0	0	1	0	0
SZT2	23334	broad.mit.edu	37	1	43904411	43904411	+	Missense_Mutation	SNP	C	C	T			TCGA-P5-A737-01A-11D-A32B-08	TCGA-P5-A737-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	936493de-1bf3-4ba3-8fd1-3365e35605c8	732b972d-1257-41a8-905a-7407e4a36995	g.chr1:43904411C>T	ENST00000562955.1	+	46	6379	c.6379C>T	c.(6379-6381)Cgc>Tgc	p.R2127C	SZT2_ENST00000471177.1_3'UTR|SZT2_ENST00000372442.1_Missense_Mutation_p.R1285C	NM_015284.3	NP_056099.3	Q5T011	SZT2_HUMAN	seizure threshold 2 homolog (mouse)	2184						peroxisome		p.R1285C(2)|p.R2127C(1)		NS(2)|breast(9)|central_nervous_system(1)|endometrium(17)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(19)|lung(39)|ovary(4)|pancreas(3)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	113						TCTATGTCGGCGCCTGGATGA	0.572000													16	4					0	0	1	0	0
ZNF721	170960	broad.mit.edu	37	4	436239	436239	+	Missense_Mutation	SNP	C	C	T			TCGA-P5-A737-01A-11D-A32B-08	TCGA-P5-A737-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	936493de-1bf3-4ba3-8fd1-3365e35605c8	732b972d-1257-41a8-905a-7407e4a36995	g.chr4:436239C>T	ENST00000338977.5	-	2	2029	c.1981G>A	c.(1981-1983)Gag>Aag	p.E661K	ZNF721_ENST00000511833.2_Missense_Mutation_p.E673K|ZNF721_ENST00000507078.1_Intron|ZNF721_ENST00000506646.1_Intron|ABCA11P_ENST00000451020.2_RNA					zinc finger protein 721											endometrium(2)|kidney(2)|large_intestine(15)|lung(6)|ovary(1)|skin(1)|stomach(5)|urinary_tract(1)	33						TTGCCACACTCTTCACATTTG	0.418000													4	100					0	0	1	0	0
WDR38	401551	broad.mit.edu	37	9	127618017	127618017	+	Missense_Mutation	SNP	C	C	T			TCGA-P5-A737-01A-11D-A32B-08	TCGA-P5-A737-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	936493de-1bf3-4ba3-8fd1-3365e35605c8	732b972d-1257-41a8-905a-7407e4a36995	g.chr9:127618017C>T	ENST00000373574.1	+	3	351	c.295C>T	c.(295-297)Cgg>Tgg	p.R99W		NM_001045476.1|NM_001276374.1	NP_001038941.1|NP_001263303.1	Q5JTN6	WDR38_HUMAN	WD repeat domain 38	99										breast(1)|large_intestine(1)|lung(4)|prostate(1)|skin(1)	8						GAAGTGTCTGCGGGTCCTGAA	0.617000											OREG0019485	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	87					0	0	1	0	0
GIF	2694	broad.mit.edu	37	11	59612897	59612897	+	Silent	SNP	G	G	A			TCGA-P5-A737-01A-11D-A32B-08	TCGA-P5-A737-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	936493de-1bf3-4ba3-8fd1-3365e35605c8	732b972d-1257-41a8-905a-7407e4a36995	g.chr11:59612897G>A	ENST00000257248.2	-	1	77	c.30C>T	c.(28-30)agC>agT	p.S10S	GIF_ENST00000541311.1_5'UTR	NM_005142.2	NP_005133.2	P27352	IF_HUMAN	gastric intrinsic factor (vitamin B synthesis)	10					cobalamin metabolic process|cobalamin transport|cobalt ion transport	apical plasma membrane|endosome|extracellular space|microvillus	cobalamin binding			large_intestine(4)|liver(1)|lung(6)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	17						CCCAGAGAAGGCTCAGGAGGT	0.512000													14	97					0	0	1	0	0
PLXNA3	55558	broad.mit.edu	37	X	153697253	153697253	+	Missense_Mutation	SNP	G	G	A			TCGA-P5-A737-01A-11D-A32B-08	TCGA-P5-A737-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	936493de-1bf3-4ba3-8fd1-3365e35605c8	732b972d-1257-41a8-905a-7407e4a36995	g.chrX:153697253G>A	ENST00000369682.3	+	25	4550	c.4375G>A	c.(4375-4377)Gca>Aca	p.A1459T		NM_017514.3	NP_059984.2	P51805	PLXA3_HUMAN	plexin A3	1459					axon guidance	integral to membrane|intracellular|plasma membrane	transmembrane receptor activity			breast(2)|central_nervous_system(2)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(26)|ovary(2)|prostate(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	48	all_cancers(53;5.05e-16)|all_epithelial(53;1.87e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					CACGGGCGAGGCACGATACTC	0.617000													3	41					0	0	1	0	0
EP400	57634	broad.mit.edu	37	12	132547087	132547087	+	Silent	SNP	G	G	A	rs12366766		TCGA-P5-A737-01A-11D-A32B-08	TCGA-P5-A737-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	936493de-1bf3-4ba3-8fd1-3365e35605c8	732b972d-1257-41a8-905a-7407e4a36995	g.chr12:132547087G>A	ENST00000333577.4	+	48	8392	c.8283G>A	c.(8281-8283)caG>caA	p.Q2761Q	EP400_ENST00000389561.2_Silent_p.Q2725Q|EP400_ENST00000330386.6_Silent_p.Q2644Q|EP400_ENST00000332482.4_Silent_p.Q2688Q|EP400_ENST00000389562.2_Silent_p.Q2724Q			Q96L91	EP400_HUMAN	E1A binding protein p400	2761	Interaction with ZNF42 (By similarity).|Poly-Gln.				histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nuclear speck	ATP binding|DNA binding|helicase activity	p.Q2724Q(16)|p.Q2725Q(1)		NS(1)|breast(6)|central_nervous_system(10)|cervix(1)|endometrium(21)|kidney(13)|large_intestine(25)|lung(56)|ovary(5)|prostate(8)|skin(6)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	161	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.198)		OV - Ovarian serous cystadenocarcinoma(86;3.01e-08)|Epithelial(86;3.43e-07)|all cancers(50;2.01e-06)		agcagcagcagcaacaacagc	0.562000													3	30					0	0	1	0	0
FSIP2	401024	broad.mit.edu	37	2	186673362	186673362	+	Missense_Mutation	SNP	A	A	G			TCGA-P5-A737-01A-11D-A32B-08	TCGA-P5-A737-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	936493de-1bf3-4ba3-8fd1-3365e35605c8	732b972d-1257-41a8-905a-7407e4a36995	g.chr2:186673362A>G	ENST00000343098.5	+	17	19596	c.19596A>G	c.(19594-19596)atA>atG	p.I6532M	FSIP2_ENST00000424728.1_Missense_Mutation_p.I6443M	NM_173651.2	NP_775922.2			fibrous sheath interacting protein 2											NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(4)|kidney(1)|large_intestine(11)|lung(46)|pancreas(1)|urinary_tract(2)	69						ATTATGATATAAAAGATACAA	0.289000													23	18					0	0	1	0	0
OR13C5	138799	broad.mit.edu	37	9	107361002	107361002	+	Silent	SNP	C	C	T	rs78992791	byFrequency	TCGA-P5-A737-01A-11D-A32B-08	TCGA-P5-A737-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	936493de-1bf3-4ba3-8fd1-3365e35605c8	732b972d-1257-41a8-905a-7407e4a36995	g.chr9:107361002C>T	ENST00000374779.2	-	1	786	c.693G>A	c.(691-693)tcG>tcA	p.S231S		NM_001004482.1	NP_001004482.1	Q8NGS8	O13C5_HUMAN	olfactory receptor, family 13, subfamily C, member 5	231					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(4)|kidney(1)|large_intestine(2)|lung(11)|ovary(2)|pancreas(2)|prostate(2)|skin(4)	28						TTCTCCCCTCCGAAGAGCTAA	0.428000													40	63					0	0	1	0	0
PHIP	55023	broad.mit.edu	37	6	79770432	79770432	+	Missense_Mutation	SNP	T	T	G			TCGA-P5-A737-01A-11D-A32B-08	TCGA-P5-A737-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	936493de-1bf3-4ba3-8fd1-3365e35605c8	732b972d-1257-41a8-905a-7407e4a36995	g.chr6:79770432T>G	ENST00000275034.4	-	5	460	c.293A>C	c.(292-294)cAa>cCa	p.Q98P		NM_017934.5	NP_060404.3	Q8WWQ0	PHIP_HUMAN	pleckstrin homology domain interacting protein	98					insulin receptor signaling pathway|negative regulation of apoptosis|positive regulation of cell proliferation|positive regulation of insulin-like growth factor receptor signaling pathway|positive regulation of mitosis	nucleus	insulin receptor binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(10)|kidney(4)|large_intestine(20)|lung(20)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	68		all_cancers(76;0.00125)|Acute lymphoblastic leukemia(125;1.1e-05)|all_hematologic(105;0.00117)|all_epithelial(107;0.219)		BRCA - Breast invasive adenocarcinoma(397;0.231)		TAATAAAGTTTGTACTCCAGG	0.343000													12	30					0	0	1	0	0
TTC23	64927	broad.mit.edu	37	15	99678297	99678297	+	Nonsense_Mutation	SNP	G	G	C			TCGA-P5-A737-01A-11D-A32B-08	TCGA-P5-A737-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	936493de-1bf3-4ba3-8fd1-3365e35605c8	732b972d-1257-41a8-905a-7407e4a36995	g.chr15:99678297G>C	ENST00000394132.2	-	14	2079	c.1262C>G	c.(1261-1263)tCa>tGa	p.S421*	TTC23_ENST00000394135.3_Nonsense_Mutation_p.S421*|TTC23_ENST00000394136.1_Nonsense_Mutation_p.S421*|TTC23_ENST00000262074.4_Nonsense_Mutation_p.S421*|TTC23_ENST00000558613.1_Nonsense_Mutation_p.S421*|TTC23_ENST00000558663.1_Nonsense_Mutation_p.S421*			Q5W5X9	TTC23_HUMAN	tetratricopeptide repeat domain 23	421							binding			endometrium(2)|large_intestine(3)|lung(9)|urinary_tract(2)	16	all_cancers(4;1.49e-13)|Lung NSC(78;0.000545)|all_lung(78;0.00121)|Melanoma(26;0.00505)|Medulloblastoma(229;0.163)		all cancers(5;8.11e-09)|OV - Ovarian serous cystadenocarcinoma(32;0.00215)			TTTGGCTTTTGATGCCTGCCT	0.637000													19	19					0	0	1	0	0
SS18L2	51188	broad.mit.edu	37	3	42632448	42632448	+	Missense_Mutation	SNP	C	C	T			TCGA-P5-A737-01A-11D-A32B-08	TCGA-P5-A737-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	936493de-1bf3-4ba3-8fd1-3365e35605c8	732b972d-1257-41a8-905a-7407e4a36995	g.chr3:42632448C>T	ENST00000447630.1	+	2	267	c.59C>T	c.(58-60)aCt>aTt	p.T20I	SEC22C_ENST00000417572.1_Intron|SS18L2_ENST00000011691.4_Missense_Mutation_p.T20I			Q9UHA2	S18L2_HUMAN	synovial sarcoma translocation gene on chromosome 18-like 2	20										prostate(1)	1				KIRC - Kidney renal clear cell carcinoma(284;0.214)		AATCAAGAGACTATCCAGCGG	0.667000													24	39					0	0	1	0	0
XCL2	6846	broad.mit.edu	37	1	168510202	168510202	+	Silent	SNP	G	G	A	rs149372418	byFrequency	TCGA-P5-A737-01A-11D-A32B-08	TCGA-P5-A737-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	936493de-1bf3-4ba3-8fd1-3365e35605c8	732b972d-1257-41a8-905a-7407e4a36995	g.chr1:168510202G>A	ENST00000367819.2	-	3	365	c.333C>T	c.(331-333)acC>acT	p.T111T		NM_003175.3	NP_003166.1	Q9UBD3	XCL2_HUMAN	chemokine (C motif) ligand 2	111					blood circulation|chemotaxis|immune response|signal transduction	extracellular space	chemokine activity	p.T111T(1)		large_intestine(1)|lung(6)|ovary(1)	8	all_hematologic(923;0.215)					AGCCAGTCAGGGTCACAGCTG	0.498000													5	39					0	0	1	0	0
SLC34A2	10568	broad.mit.edu	37	4	25678090	25678090	+	Missense_Mutation	SNP	C	C	T			TCGA-P5-A737-01A-11D-A32B-08	TCGA-P5-A737-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	936493de-1bf3-4ba3-8fd1-3365e35605c8	732b972d-1257-41a8-905a-7407e4a36995	g.chr4:25678090C>T	ENST00000382051.3	+	13	1842	c.1792C>T	c.(1792-1794)Cgc>Tgc	p.R598C	SLC34A2_ENST00000503434.1_Missense_Mutation_p.R597C|SLC34A2_ENST00000504570.1_Missense_Mutation_p.R597C	NM_001177998.1|NM_006424.2	NP_001171469.1|NP_006415.2	O95436	NPT2B_HUMAN	solute carrier family 34 (type II sodium/phosphate contransporter), member 2	598					cellular phosphate ion homeostasis	apical plasma membrane|brush border membrane|integral to plasma membrane	phosphate binding|sodium ion binding|sodium-dependent phosphate transmembrane transporter activity|sodium:phosphate symporter activity	p.R598C(1)	SLC34A2/ROS1(14)	breast(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(9)|lung(18)|ovary(1)|prostate(1)|skin(4)	41		Breast(46;0.0503)				GCTGTGGATGCGCTCGCTGAA	0.632000			T	ROS1	NSCLC								4	69					0	0	1	0	0
SLC38A2	54407	broad.mit.edu	37	12	46758436	46758436	+	Silent	SNP	A	A	G			TCGA-P5-A737-01A-11D-A32B-08	TCGA-P5-A737-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	936493de-1bf3-4ba3-8fd1-3365e35605c8	732b972d-1257-41a8-905a-7407e4a36995	g.chr12:46758436A>G	ENST00000256689.5	-	9	1140	c.696T>C	c.(694-696)ttT>ttC	p.F232F	SLC38A2_ENST00000547252.1_5'UTR|SLC38A2_ENST00000551374.1_Silent_p.F70F	NM_018976.4	NP_061849.2	Q96QD8	S38A2_HUMAN	solute carrier family 38, member 2	232					cellular nitrogen compound metabolic process|glutamate secretion|neurotransmitter secretion|sodium ion transport	integral to membrane|plasma membrane	amino acid transmembrane transporter activity|symporter activity			cervix(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(5)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	18	Lung SC(27;0.192)|Renal(347;0.236)		OV - Ovarian serous cystadenocarcinoma(5;0.0048)|Epithelial(2;0.0374)	GBM - Glioblastoma multiforme(48;0.226)		CCACAATCAGAAAGAACACCA	0.328000													22	29					0	0	1	0	0
KPRP	448834	broad.mit.edu	37	1	152732999	152732999	+	Missense_Mutation	SNP	G	G	A			TCGA-P5-A737-01A-11D-A32B-08	TCGA-P5-A737-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	936493de-1bf3-4ba3-8fd1-3365e35605c8	732b972d-1257-41a8-905a-7407e4a36995	g.chr1:152732999G>A	ENST00000368773.1	+	2	993	c.935G>A	c.(934-936)cGc>cAc	p.R312H	KPRP_ENST00000606109.1_Missense_Mutation_p.R312H	NM_001025231.1	NP_001020402.1	Q5T749	KPRP_HUMAN	keratinocyte proline-rich protein	312	Pro-rich.					cytoplasm				NS(1)|breast(1)|endometrium(9)|kidney(1)|large_intestine(10)|lung(21)|ovary(6)|pancreas(1)|prostate(6)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	60	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			TGTCCTCGCCGCCCCATTTCA	0.592000													3	52					0	0	1	0	0
HIST1H1T	3010	broad.mit.edu	37	6	26107808	26107808	+	Missense_Mutation	SNP	C	C	T			TCGA-P5-A737-01A-11D-A32B-08	TCGA-P5-A737-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	936493de-1bf3-4ba3-8fd1-3365e35605c8	732b972d-1257-41a8-905a-7407e4a36995	g.chr6:26107808C>T	ENST00000338379.4	-	1	556	c.514G>A	c.(514-516)Gga>Aga	p.G172R		NM_005323.3	NP_005314.2	P22492	H1T_HUMAN	histone cluster 1, H1t	172					cell differentiation|multicellular organismal development|nucleosome assembly|spermatogenesis	nucleosome	DNA binding			breast(2)|endometrium(1)|lung(3)|ovary(2)|prostate(1)	9						CCCTTGGCTCCTTTAGCCTTT	0.478000													32	58					0	0	1	0	0
DHRS9	10170	broad.mit.edu	37	2	169939889	169939889	+	Missense_Mutation	SNP	A	A	C			TCGA-P5-A737-01A-11D-A32B-08	TCGA-P5-A737-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	936493de-1bf3-4ba3-8fd1-3365e35605c8	732b972d-1257-41a8-905a-7407e4a36995	g.chr2:169939889A>C	ENST00000327239.4	+	6	1868	c.364A>C	c.(364-366)Act>Cct	p.T122P	DHRS9_ENST00000412271.1_Missense_Mutation_p.T122P|DHRS9_ENST00000602501.1_Missense_Mutation_p.T122P|DHRS9_ENST00000436483.2_Missense_Mutation_p.T122P|DHRS9_ENST00000432060.2_Missense_Mutation_p.T182P|DHRS9_ENST00000421653.1_5'UTR|DHRS9_ENST00000357546.2_Missense_Mutation_p.T122P|DHRS9_ENST00000428522.1_Missense_Mutation_p.T122P	NM_005771.4	NP_005762.2	Q9BPW9	DHRS9_HUMAN	dehydrogenase/reductase (SDR family) member 9	122					9-cis-retinoic acid biosynthetic process|androgen metabolic process|epithelial cell differentiation|progesterone metabolic process|retinol metabolic process	integral to endoplasmic reticulum membrane|microsome	alcohol dehydrogenase (NAD) activity|binding|racemase and epimerase activity|retinol dehydrogenase activity|testosterone dehydrogenase (NAD+) activity			breast(1)|endometrium(3)|large_intestine(2)|lung(5)|skin(1)|upper_aerodigestive_tract(1)	13						GCTGGCTCCCACTGACTGGCT	0.473000													42	31					0	0	1	0	0
ZNF333	84449	broad.mit.edu	37	19	14830055	14830055	+	Missense_Mutation	SNP	C	C	G			TCGA-P5-A737-01A-11D-A32B-08	TCGA-P5-A737-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	936493de-1bf3-4ba3-8fd1-3365e35605c8	732b972d-1257-41a8-905a-7407e4a36995	g.chr19:14830055C>G	ENST00000292530.6	+	12	2007	c.1916C>G	c.(1915-1917)aCc>aGc	p.T639S	ZNF333_ENST00000540689.2_Intron|ZNF333_ENST00000536363.1_Missense_Mutation_p.T530S	NM_032433.2	NP_115809.1	Q96JL9	ZN333_HUMAN	zinc finger protein 333	639					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(5)|ovary(2)|pancreas(1)|prostate(1)	21						CACAAAAGAACCCATGTGGGA	0.453000													7	67					0	0	1	0	0
NLRC3	197358	broad.mit.edu	37	16	3606946	3606946	+	RNA	SNP	C	C	T			TCGA-P5-A737-01A-11D-A32B-08	TCGA-P5-A737-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	936493de-1bf3-4ba3-8fd1-3365e35605c8	732b972d-1257-41a8-905a-7407e4a36995	g.chr16:3606946C>T	ENST00000301749.7	-	0	2554				NLRC3_ENST00000359128.5_RNA|NLRC3_ENST00000448023.2_RNA|NLRC3_ENST00000419350.2_RNA|NLRC3_ENST00000603507.1_RNA	NM_178844.2	NP_849172.2	Q7RTR2	NLRC3_HUMAN	NLR family, CARD domain containing 3						I-kappaB kinase/NF-kappaB cascade|negative regulation of NF-kappaB transcription factor activity|T cell activation	cytoplasm	ATP binding			breast(1)|central_nervous_system(2)|endometrium(1)|kidney(3)|large_intestine(1)|liver(1)|lung(16)|ovary(2)|pancreas(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	34						ATCTTCAAAGCGTCTGCCAGC	0.582000													11	10					0	0	1	0	0
FRG1B	0	broad.mit.edu	37	20	29628300	29628300	+	Missense_Mutation	SNP	G	G	A			TCGA-P5-A737-01A-11D-A32B-08	TCGA-P5-A737-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	936493de-1bf3-4ba3-8fd1-3365e35605c8	732b972d-1257-41a8-905a-7407e4a36995	g.chr20:29628300G>A	ENST00000278882.3	+	6	682	c.302G>A	c.(301-303)aGt>aAt	p.S101N	FRG1B_ENST00000358464.4_Missense_Mutation_p.S101N|FRG1B_ENST00000439954.2_Missense_Mutation_p.S106N														p.S101N(2)		endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						GAAGCAAAAAGTAAAACAGCA	0.358000													4	80					0	0	1	0	0
KIAA1211	57482	broad.mit.edu	37	4	57179385	57179385	+	Missense_Mutation	SNP	G	G	A			TCGA-P5-A737-01A-11D-A32B-08	TCGA-P5-A737-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	936493de-1bf3-4ba3-8fd1-3365e35605c8	732b972d-1257-41a8-905a-7407e4a36995	g.chr4:57179385G>A	ENST00000504228.1	+	5	482	c.377G>A	c.(376-378)cGg>cAg	p.R126Q	KIAA1211_ENST00000541073.1_Missense_Mutation_p.R119Q|KIAA1211_ENST00000264229.6_Missense_Mutation_p.R126Q			Q6ZU35	K1211_HUMAN	KIAA1211	126										endometrium(7)|large_intestine(10)|lung(39)|ovary(2)|prostate(3)|skin(3)|stomach(1)	65	Glioma(25;0.08)|all_neural(26;0.101)					AAACCGTCTCGGCCAAAAAGG	0.537000													10	100					0	0	1	0	0
HDHD3	81932	broad.mit.edu	37	9	116136675	116136675	+	Translation_Start_Site	SNP	C	C	T			TCGA-P5-A737-01A-11D-A32B-08	TCGA-P5-A737-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	936493de-1bf3-4ba3-8fd1-3365e35605c8	732b972d-1257-41a8-905a-7407e4a36995	g.chr9:116136675C>T	ENST00000238379.5	-	0	857				HDHD3_ENST00000374180.3_De_novo_Start_OutOfFrame|HDHD3_ENST00000485934.1_5'UTR	NM_031219.2	NP_112496.1	Q9BSH5	HDHD3_HUMAN	haloacid dehalogenase-like hydrolase domain containing 3								phosphoglycolate phosphatase activity|protein binding			large_intestine(2)|liver(1)	3						TCAGGTCCCACGGTGGGTCCC	0.587000													5	9					0	0	1	0	0
OR4C15	81309	broad.mit.edu	37	11	55322861	55322861	+	Missense_Mutation	SNP	T	T	C			TCGA-P5-A737-01A-11D-A32B-08	TCGA-P5-A737-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	936493de-1bf3-4ba3-8fd1-3365e35605c8	732b972d-1257-41a8-905a-7407e4a36995	g.chr11:55322861T>C	ENST00000314644.2	+	1	1079	c.1079T>C	c.(1078-1080)gTg>gCg	p.V360A		NM_001001920.1	NP_001001920.1	Q8NGM1	OR4CF_HUMAN	olfactory receptor, family 4, subfamily C, member 15	306					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(7)|lung(31)|ovary(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(5)	56						AGACTGATGGTGGTTTCTGAT	0.303000										HNSCC(20;0.049)			4	66					0	0	1	0	0
IDH1	3417	broad.mit.edu	37	2	209113112	209113112	+	Missense_Mutation	SNP	C	C	T	rs121913500		TCGA-P5-A737-01A-11D-A32B-08	TCGA-P5-A737-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	936493de-1bf3-4ba3-8fd1-3365e35605c8	732b972d-1257-41a8-905a-7407e4a36995	g.chr2:209113112C>T	ENST00000415913.1	-	4	776	c.395G>A	c.(394-396)cGt>cAt	p.R132H	IDH1_ENST00000345146.2_Missense_Mutation_p.R132H|IDH1_ENST00000446179.1_Missense_Mutation_p.R132H			O75874	IDHC_HUMAN	isocitrate dehydrogenase 1 (NADP+), soluble	132			R -> C (in colorectal cancer and glioma samples; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha- ketoglutarate but instead alpha- ketoglutarate is converted to R(-)-2- hydroxyglutarate).|R -> G (in a glioma sample; glioblastoma multiforme; somatic mutation).|R -> H (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> L (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> S (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).		2-oxoglutarate metabolic process|cellular lipid metabolic process|glyoxylate cycle|isocitrate metabolic process|NADPH regeneration|tricarboxylic acid cycle	cytosol|peroxisomal matrix	isocitrate dehydrogenase (NADP+) activity|magnesium ion binding|NAD binding|protein homodimerization activity	p.R132H(2774)|p.R132L(59)|p.R132V(1)|p.G131_R132>VL(1)		NS(1)|autonomic_ganglia(2)|biliary_tract(24)|bone(237)|central_nervous_system(3764)|endometrium(3)|haematopoietic_and_lymphoid_tissue(794)|kidney(2)|large_intestine(7)|lung(7)|prostate(6)|skin(5)|soft_tissue(12)|thyroid(22)|urinary_tract(1)	4887				Epithelial(149;0.0322)|LUSC - Lung squamous cell carcinoma(261;0.0711)|Lung(261;0.136)		ATAAGCATGACGACCTATGAT	0.393000			Mis		gliobastoma								23	16					0	0	1	0	0
OR14I1	401994	broad.mit.edu	37	1	248844917	248844917	+	Missense_Mutation	SNP	T	T	C			TCGA-P5-A737-01A-11D-A32B-08	TCGA-P5-A737-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	936493de-1bf3-4ba3-8fd1-3365e35605c8	732b972d-1257-41a8-905a-7407e4a36995	g.chr1:248844917T>C	ENST00000342623.3	-	1	712	c.689A>G	c.(688-690)cAg>cGg	p.Q230R		NM_001004734.1	NP_001004734.1	A6ND48	O14I1_HUMAN	olfactory receptor, family 14, subfamily I, member 1	230					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(4)|large_intestine(2)|lung(24)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)	35						TGCTCGACTCTGTCCTGAAGG	0.493000													5	63					0	0	1	0	0
AHDC1	27245	broad.mit.edu	37	1	27875316	27875316	+	Missense_Mutation	SNP	C	C	T			TCGA-P5-A737-01A-11D-A32B-08	TCGA-P5-A737-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	936493de-1bf3-4ba3-8fd1-3365e35605c8	732b972d-1257-41a8-905a-7407e4a36995	g.chr1:27875316C>T	ENST00000374011.2	-	6	4279	c.3311G>A	c.(3310-3312)gGg>gAg	p.G1104E	AHDC1_ENST00000482400.2_Intron|AHDC1_ENST00000247087.5_Missense_Mutation_p.G1104E	NM_001029882.2	NP_001025053.1	Q5TGY3	AHDC1_HUMAN	AT hook, DNA binding motif, containing 1	1104							DNA binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(8)|lung(20)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	42		all_lung(284;1.06e-05)|Lung NSC(340;1.86e-05)|Colorectal(325;3.46e-05)|Renal(390;0.0007)|Breast(348;0.0021)|Ovarian(437;0.00503)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0434)|OV - Ovarian serous cystadenocarcinoma(117;8.48e-25)|Colorectal(126;9.17e-09)|COAD - Colon adenocarcinoma(152;1.84e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.00192)|BRCA - Breast invasive adenocarcinoma(304;0.00259)|STAD - Stomach adenocarcinoma(196;0.00311)|READ - Rectum adenocarcinoma(331;0.0291)		CTGAGAAGCCCCCGCAAACTG	0.637000													5	39					0	0	1	0	0
LIPE-AS1	0	broad.mit.edu	37	19	43009588	43009589	+	RNA	INS	-	-	T			TCGA-P5-A737-01A-11D-A32B-08	TCGA-P5-A737-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	936493de-1bf3-4ba3-8fd1-3365e35605c8	732b972d-1257-41a8-905a-7407e4a36995	g.chr19:43009588_43009589insT	ENST00000594688.1	+	0	1450				LIPE-AS1_ENST00000457234.2_RNA|LIPE-AS1_ENST00000594624.2_RNA	NR_073179.1																						GAAGAAACttcttttttttctt	0.455													2	4	---	---	---	---					
ZNF444	55311	broad.mit.edu	37	19	56658436	56658436	+	Frame_Shift_Del	DEL	G	G	-			TCGA-P5-A737-01A-11D-A32B-08	TCGA-P5-A737-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	936493de-1bf3-4ba3-8fd1-3365e35605c8	732b972d-1257-41a8-905a-7407e4a36995	g.chr19:56658436delG	ENST00000337080.3	+	3	523	c.156delG	c.(154-156)gafs	p.E52fs	ZNF444_ENST00000592949.1_Frame_Shift_Del_p.E52fs	NM_001253792.1|NM_018337.3	NP_001240721.1|NP_060807.2	Q8N0Y2	ZN444_HUMAN	zinc finger protein 444	52	SCAN box.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|endometrium(1)|lung(5)	7		Colorectal(82;3.46e-05)|Ovarian(87;0.0822)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0531)		TGCGGCCCGAGGTGCACACCA	0.746													2	4	---	---	---	---