Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
RFX1	5989	broad.mit.edu	37	19	14094339	14094339	+	Missense_Mutation	SNP	C	C	T			TCGA-E1-A7Z2-01A-21D-A34J-08	TCGA-E1-A7Z2-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53d89c8c-9732-4d1b-9cf3-49f1fb294853	2fc2d89c-126c-4a1f-987f-aa357fc63c67	g.chr19:14094339C>T	ENST00000254325.4	-	3	622	c.388G>A	c.(388-390)Gtt>Att	p.V130I		NM_002918.4	NP_002909.4	P22670	RFX1_HUMAN	regulatory factor X, 1 (influences HLA class II expression)	130					immune response	nucleus	DNA binding|protein binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity			NS(1)|breast(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(8)|ovary(2)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	21			OV - Ovarian serous cystadenocarcinoma(19;6.67e-23)			TGAGTAGGAACGCCGGTCTGG	0.706000													5	14					0	0	1	0	0
NCOA3	8202	broad.mit.edu	37	20	46262895	46262895	+	Silent	SNP	A	A	T			TCGA-E1-A7Z2-01A-21D-A34J-08	TCGA-E1-A7Z2-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53d89c8c-9732-4d1b-9cf3-49f1fb294853	2fc2d89c-126c-4a1f-987f-aa357fc63c67	g.chr20:46262895A>T	ENST00000372004.3	+	10	1284	c.1068A>T	c.(1066-1068)gtA>gtT	p.V356V	NCOA3_ENST00000371998.3_Silent_p.V356V|NCOA3_ENST00000371997.3_Silent_p.V366V|NCOA3_ENST00000341724.6_Silent_p.V366V	NM_001174087.1|NM_001174088.1|NM_006534.3|NM_181659.2	NP_001167558.1|NP_001167559.1|NP_006525.2|NP_858045.1	Q9Y6Q9	NCOA3_HUMAN	nuclear receptor coactivator 3	356					androgen receptor signaling pathway|cellular lipid metabolic process|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleoplasm	androgen receptor binding|histone acetyltransferase activity|ligand-dependent nuclear receptor binding|protein N-terminus binding|signal transducer activity|thyroid hormone receptor binding			breast(3)|endometrium(3)|kidney(4)|large_intestine(12)|lung(19)|ovary(4)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	52						GAAATCCTGTAACAAATGATC	0.403000													43	166					0	0	1	0	0
GDAP1L1	78997	broad.mit.edu	37	20	42885841	42885841	+	Missense_Mutation	SNP	G	G	A			TCGA-E1-A7Z2-01A-21D-A34J-08	TCGA-E1-A7Z2-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53d89c8c-9732-4d1b-9cf3-49f1fb294853	2fc2d89c-126c-4a1f-987f-aa357fc63c67	g.chr20:42885841G>A	ENST00000342560.5	+	2	317	c.229G>A	c.(229-231)Gtg>Atg	p.V77M	GDAP1L1_ENST00000372952.3_Missense_Mutation_p.V77M|GDAP1L1_ENST00000537864.1_Intron	NM_001256737.1|NM_024034.4	NP_001243666.1|NP_076939.3	Q96MZ0	GD1L1_HUMAN	ganglioside induced differentiation associated protein 1-like 1	77	GST N-terminal.									endometrium(1)|large_intestine(5)|lung(10)|pancreas(1)|prostate(1)	18		Myeloproliferative disorder(115;0.0122)	COAD - Colon adenocarcinoma(18;0.00189)			GGAGCGGGACGTGAGCCTGCC	0.667000													17	17					0	0	1	0	0
KSR1	8844	broad.mit.edu	37	17	25783779	25783779	+	Missense_Mutation	SNP	C	C	A	rs143611966	by1000genomes	TCGA-E1-A7Z2-01A-21D-A34J-08	TCGA-E1-A7Z2-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53d89c8c-9732-4d1b-9cf3-49f1fb294853	2fc2d89c-126c-4a1f-987f-aa357fc63c67	g.chr17:25783779C>A	ENST00000319524.6	+	1	110	c.110C>A	c.(109-111)gCg>gAg	p.A37E	KSR1_ENST00000509603.2_Missense_Mutation_p.A37E			Q8IVT5	KSR1_HUMAN	kinase suppressor of ras 1	35					Ras protein signal transduction	cytoplasm|membrane	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity	p.A37E(2)		NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|large_intestine(5)|lung(12)|prostate(2)|urinary_tract(1)	28	Lung NSC(42;0.00836)		BRCA - Breast invasive adenocarcinoma(3;0.00122)	UCEC - Uterine corpus endometrioid carcinoma (53;0.168)		GCCAGCCGGGCGCTGCAGCAG	0.741000													4	32					0.00024832	0.000257871	1	1	0
ACRC	93953	broad.mit.edu	37	X	70828953	70828953	+	Missense_Mutation	SNP	G	G	A			TCGA-E1-A7Z2-01A-21D-A34J-08	TCGA-E1-A7Z2-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53d89c8c-9732-4d1b-9cf3-49f1fb294853	2fc2d89c-126c-4a1f-987f-aa357fc63c67	g.chrX:70828953G>A	ENST00000373695.1	+	9	2134	c.1597G>A	c.(1597-1599)Gtc>Atc	p.V533I	ACRC_ENST00000373696.3_Missense_Mutation_p.V533I|ACRC_ENST00000471950.1_3'UTR			Q96QF7	ACRC_HUMAN	acidic repeat containing	533						nucleus				autonomic_ganglia(1)|breast(1)|endometrium(15)|kidney(4)|large_intestine(4)|lung(20)|ovary(5)|prostate(1)|skin(2)|stomach(1)	54	Renal(35;0.156)					TAACAGATCCGTCTGTGATAA	0.393000													20	32					0	0	1	0	0
FAM86FP	0	broad.mit.edu	37	12	8386955	8386955	+	RNA	SNP	T	T	C	rs75997195		TCGA-E1-A7Z2-01A-21D-A34J-08	TCGA-E1-A7Z2-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53d89c8c-9732-4d1b-9cf3-49f1fb294853	2fc2d89c-126c-4a1f-987f-aa357fc63c67	g.chr12:8386955T>C	ENST00000427893.2	-	0	811																											CTTGTGCTCCTGGCAGGCAGC	0.612000													4	87					0	0	1	0	0
IGHG4	0	broad.mit.edu	37	14	106090898	106090898	+	RNA	SNP	C	C	T			TCGA-E1-A7Z2-01A-21D-A34J-08	TCGA-E1-A7Z2-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53d89c8c-9732-4d1b-9cf3-49f1fb294853	2fc2d89c-126c-4a1f-987f-aa357fc63c67	g.chr14:106090898C>T	ENST00000390543.2	-	0	898																											GAAGACATTCCCCTCCTGCCA	0.587000													68	44					0	0	1	0	0
MED28	80306	broad.mit.edu	37	4	17616293	17616293	+	Missense_Mutation	SNP	G	G	C			TCGA-E1-A7Z2-01A-21D-A34J-08	TCGA-E1-A7Z2-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53d89c8c-9732-4d1b-9cf3-49f1fb294853	2fc2d89c-126c-4a1f-987f-aa357fc63c67	g.chr4:17616293G>C	ENST00000237380.6	+	1	40	c.16G>C	c.(16-18)Ggg>Cgg	p.G6R		NM_025205.3	NP_079481.2	Q9H204	MED28_HUMAN	mediator complex subunit 28	6					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|membrane|nucleus	actin binding			lung(6)|skin(2)	8						GGCTCCACTAGGGGGTATGTT	0.652000													19	48					0	0	1	0	0
SLC6A17	388662	broad.mit.edu	37	1	110741027	110741027	+	Silent	SNP	C	C	T	rs151260028		TCGA-E1-A7Z2-01A-21D-A34J-08	TCGA-E1-A7Z2-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53d89c8c-9732-4d1b-9cf3-49f1fb294853	2fc2d89c-126c-4a1f-987f-aa357fc63c67	g.chr1:110741027C>T	ENST00000331565.4	+	12	2630	c.2145C>T	c.(2143-2145)agC>agT	p.S715S		NM_001010898.2	NP_001010898.1	Q9H1V8	S6A17_HUMAN	solute carrier family 6 (neutral amino acid transporter), member 17	715					alanine transport|glycine transport|leucine transport|proline transport	cell junction|integral to plasma membrane|synaptic vesicle membrane	neurotransmitter:sodium symporter activity			breast(1)|endometrium(4)|kidney(4)|large_intestine(8)|lung(13)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	37		all_cancers(81;9.9e-06)|all_epithelial(167;3.24e-06)|all_lung(203;0.000116)|Lung NSC(277;0.000233)		Lung(183;0.0282)|Epithelial(280;0.0372)|all cancers(265;0.0378)|Colorectal(144;0.0438)|LUSC - Lung squamous cell carcinoma(189;0.151)|COAD - Colon adenocarcinoma(174;0.151)		GCTATGGGAGCGGCTACCTGC	0.667000													31	46					0	0	1	0	0
OR2A5	393046	broad.mit.edu	37	7	143748419	143748419	+	Silent	SNP	A	A	C			TCGA-E1-A7Z2-01A-21D-A34J-08	TCGA-E1-A7Z2-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53d89c8c-9732-4d1b-9cf3-49f1fb294853	2fc2d89c-126c-4a1f-987f-aa357fc63c67	g.chr7:143748419A>C	ENST00000408906.2	+	1	959	c.925A>C	c.(925-927)Aga>Cga	p.R309R		NM_012365.1	NP_036497.1	Q96R48	OR2A5_HUMAN	olfactory receptor, family 2, subfamily A, member 5	309					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|endometrium(3)|large_intestine(5)|lung(23)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	38	Melanoma(164;0.0783)					GTGGAAACAGAGATCAAAGTG	0.473000													28	20					0	0	1	0	0
NAA11	84779	broad.mit.edu	37	4	80246705	80246705	+	Silent	SNP	C	C	A			TCGA-E1-A7Z2-01A-21D-A34J-08	TCGA-E1-A7Z2-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53d89c8c-9732-4d1b-9cf3-49f1fb294853	2fc2d89c-126c-4a1f-987f-aa357fc63c67	g.chr4:80246705C>A	ENST00000286794.4	-	1	499	c.327G>T	c.(325-327)ctG>ctT	p.L109L		NM_032693.2	NP_116082.1	Q9BSU3	NAA11_HUMAN	N(alpha)-acetyltransferase 11, NatA catalytic subunit	109	N-acetyltransferase.					cytoplasm|nucleus	peptide alpha-N-acetyltransferase activity|protein binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|large_intestine(4)|lung(9)|ovary(1)|pancreas(1)|skin(2)	23						TCCTGACGTGCAGAGACACGT	0.532000													19	37					5.35267e-07	5.78088e-07	1	1	0
REXO1	57455	broad.mit.edu	37	19	1827746	1827746	+	Missense_Mutation	SNP	C	C	T			TCGA-E1-A7Z2-01A-21D-A34J-08	TCGA-E1-A7Z2-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53d89c8c-9732-4d1b-9cf3-49f1fb294853	2fc2d89c-126c-4a1f-987f-aa357fc63c67	g.chr19:1827746C>T	ENST00000170168.4	-	2	1136	c.1042G>A	c.(1042-1044)Gac>Aac	p.D348N	REXO1_ENST00000587524.1_5'UTR	NM_020695.3	NP_065746.3	Q8N1G1	REXO1_HUMAN	REX1, RNA exonuclease 1 homolog (S. cerevisiae)	348						nucleus	exonuclease activity|nucleic acid binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(5)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	16		Ovarian(11;1.78e-06)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GGCTGGAGGTCCCCCACGTCG	0.687000													6	11					0	0	1	0	0
NBPF1	55672	broad.mit.edu	37	1	16918653	16918653	+	Splice_Site	SNP	C	C	T			TCGA-E1-A7Z2-01A-21D-A34J-08	TCGA-E1-A7Z2-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53d89c8c-9732-4d1b-9cf3-49f1fb294853	2fc2d89c-126c-4a1f-987f-aa357fc63c67	g.chr1:16918653C>T	ENST00000430580.2	-	6	853		c.e6+1			NM_017940.3	NP_060410.2	Q3BBV0	NBPF1_HUMAN	neuroblastoma breakpoint family, member 1							cytoplasm									UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.52e-06)|COAD - Colon adenocarcinoma(227;1.05e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.179)		TCTTAACTTACTGTTGTGAAA	0.418000													4	42					0	0	1	0	0
ZSCAN10	84891	broad.mit.edu	37	16	3139727	3139727	+	Missense_Mutation	SNP	G	G	A			TCGA-E1-A7Z2-01A-21D-A34J-08	TCGA-E1-A7Z2-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53d89c8c-9732-4d1b-9cf3-49f1fb294853	2fc2d89c-126c-4a1f-987f-aa357fc63c67	g.chr16:3139727G>A	ENST00000252463.2	-	5	1630	c.1543C>T	c.(1543-1545)Cgg>Tgg	p.R515W	ZSCAN10_ENST00000538082.2_Missense_Mutation_p.R433W|ZSCAN10_ENST00000575108.1_Missense_Mutation_p.R176W	NM_032805.1	NP_116194.1	Q96SZ4	ZSC10_HUMAN	zinc finger and SCAN domain containing 10	515					negative regulation of transcription, DNA-dependent|viral reproduction	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|cervix(3)|endometrium(3)|kidney(1)|lung(8)|ovary(2)|prostate(1)|skin(4)|urinary_tract(1)	24						GTGTGCACCCGTTGGTGGCTG	0.721000													6	15					0	0	1	0	0
DCP1B	196513	broad.mit.edu	37	12	2062350	2062350	+	Missense_Mutation	SNP	C	C	G			TCGA-E1-A7Z2-01A-21D-A34J-08	TCGA-E1-A7Z2-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53d89c8c-9732-4d1b-9cf3-49f1fb294853	2fc2d89c-126c-4a1f-987f-aa357fc63c67	g.chr12:2062350C>G	ENST00000280665.6	-	7	835	c.756G>C	c.(754-756)caG>caC	p.Q252H	DCP1B_ENST00000397173.4_Missense_Mutation_p.Q150H|DCP1B_ENST00000541700.1_5'UTR|DCP1B_ENST00000540622.1_Missense_Mutation_p.Q126H	NM_152640.3	NP_689853.3	Q8IZD4	DCP1B_HUMAN	decapping mRNA 1B	252	Poly-Gln.				exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	cytosol|nucleus	hydrolase activity|protein binding	p.Q252H(8)		NS(1)|breast(1)|endometrium(6)|kidney(2)|large_intestine(3)|lung(10)|skin(1)	24			OV - Ovarian serous cystadenocarcinoma(31;0.00193)			gctgctgctgctgGTGGAGAG	0.552000													3	43					0	0	1	0	0
IBSP	3381	broad.mit.edu	37	4	88723847	88723847	+	Silent	SNP	C	C	T			TCGA-E1-A7Z2-01A-21D-A34J-08	TCGA-E1-A7Z2-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53d89c8c-9732-4d1b-9cf3-49f1fb294853	2fc2d89c-126c-4a1f-987f-aa357fc63c67	g.chr4:88723847C>T	ENST00000226284.5	+	4	214	c.147C>T	c.(145-147)gcC>gcT	p.A49A		NM_004967.3	NP_004958.2	P21815	SIAL_HUMAN	integrin-binding sialoprotein	49					biomineral tissue development|cell adhesion|ossification					breast(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(10)	21		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000333)|COAD - Colon adenocarcinoma(81;0.154)		ACAAGCATGCCTACTTTTATC	0.259000													17	33					0	0	1	0	0
ALG3	10195	broad.mit.edu	37	3	183963520	183963520	+	Missense_Mutation	SNP	C	C	T			TCGA-E1-A7Z2-01A-21D-A34J-08	TCGA-E1-A7Z2-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53d89c8c-9732-4d1b-9cf3-49f1fb294853	2fc2d89c-126c-4a1f-987f-aa357fc63c67	g.chr3:183963520C>T	ENST00000455059.1	-	2	611	c.157G>A	c.(157-159)Ggt>Agt	p.G53S	ALG3_ENST00000397676.3_Missense_Mutation_p.G93S|ALG3_ENST00000445626.2_Missense_Mutation_p.G45S|EIF2B5_ENST00000444495.1_Intron|ALG3_ENST00000418734.2_Intron			Q92685	ALG3_HUMAN	ALG3, alpha-1,3- mannosyltransferase	93					dolichol-linked oligosaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane|integral to membrane	alpha-1,3-mannosyltransferase activity			kidney(1)|large_intestine(1)|lung(6)|upper_aerodigestive_tract(1)	9	all_cancers(143;1.39e-10)|Ovarian(172;0.0339)		Epithelial(37;8.28e-34)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			CCGGTGTCACCCTGCAGTTGG	0.522000													26	27					0	0	1	0	0
LHX1	3975	broad.mit.edu	37	17	35300251	35300251	+	Silent	SNP	G	G	A			TCGA-E1-A7Z2-01A-21D-A34J-08	TCGA-E1-A7Z2-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53d89c8c-9732-4d1b-9cf3-49f1fb294853	2fc2d89c-126c-4a1f-987f-aa357fc63c67	g.chr17:35300251G>A	ENST00000254457.5	+	5	2455	c.1044G>A	c.(1042-1044)gcG>gcA	p.A348A	RP11-445F12.2_ENST00000607336.1_RNA	NM_005568.3	NP_005559.2	P48742	LHX1_HUMAN	LIM homeobox 1	348					cerebellar Purkinje cell differentiation|cerebellar Purkinje cell-granule cell precursor cell signaling involved in regulation of granule cell precursor cell proliferation|cervix development|comma-shaped body morphogenesis|dorsal/ventral pattern formation|ectoderm formation|embryonic pattern specification|embryonic retina morphogenesis in camera-type eye|embryonic viscerocranium morphogenesis|endoderm formation|forebrain regionalization|head development|motor axon guidance|negative regulation of transcription, DNA-dependent|nephric duct morphogenesis|nephron tubule epithelial cell differentiation|neuron migration|oviduct epithelium development|paramesonephric duct development|positive regulation of anterior head development|positive regulation of branching involved in ureteric bud morphogenesis|positive regulation of embryonic development|positive regulation of gastrulation|positive regulation of transcription, DNA-dependent|post-embryonic development|primitive streak formation|renal vesicle morphogenesis|retina layer formation|S-shaped body morphogenesis|spinal cord association neuron differentiation|transcription from RNA polymerase II promoter|ureteric bud development|uterine epithelium development|vagina development	nucleus|protein complex	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			NS(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(1)|lung(5)|ovary(1)|prostate(1)|skin(1)	16		Breast(25;0.00607)				ACATCCTGGCGCACCCACCCG	0.746000													9	9					0	0	1	0	0
FAM86JP	0	broad.mit.edu	37	3	125647387	125647387	+	RNA	SNP	G	G	A			TCGA-E1-A7Z2-01A-21D-A34J-08	TCGA-E1-A7Z2-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53d89c8c-9732-4d1b-9cf3-49f1fb294853	2fc2d89c-126c-4a1f-987f-aa357fc63c67	g.chr3:125647387G>A	ENST00000485843.1	+	0	532					NR_024251.1																						ACCAGAAACTGTTTCCCTATG	0.502000													4	136					0	0	1	0	0
NCOA3	8202	broad.mit.edu	37	20	46262897	46262897	+	Missense_Mutation	SNP	C	C	G			TCGA-E1-A7Z2-01A-21D-A34J-08	TCGA-E1-A7Z2-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53d89c8c-9732-4d1b-9cf3-49f1fb294853	2fc2d89c-126c-4a1f-987f-aa357fc63c67	g.chr20:46262897C>G	ENST00000372004.3	+	10	1286	c.1070C>G	c.(1069-1071)aCa>aGa	p.T357R	NCOA3_ENST00000371998.3_Missense_Mutation_p.T357R|NCOA3_ENST00000371997.3_Missense_Mutation_p.T367R|NCOA3_ENST00000341724.6_Missense_Mutation_p.T367R	NM_001174087.1|NM_001174088.1|NM_006534.3|NM_181659.2	NP_001167558.1|NP_001167559.1|NP_006525.2|NP_858045.1	Q9Y6Q9	NCOA3_HUMAN	nuclear receptor coactivator 3	357					androgen receptor signaling pathway|cellular lipid metabolic process|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleoplasm	androgen receptor binding|histone acetyltransferase activity|ligand-dependent nuclear receptor binding|protein N-terminus binding|signal transducer activity|thyroid hormone receptor binding			breast(3)|endometrium(3)|kidney(4)|large_intestine(12)|lung(19)|ovary(4)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	52						AATCCTGTAACAAATGATCGA	0.403000													40	165					0	0	1	0	0
MPPED1	758	broad.mit.edu	37	22	43821099	43821099	+	Silent	SNP	G	G	A			TCGA-E1-A7Z2-01A-21D-A34J-08	TCGA-E1-A7Z2-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53d89c8c-9732-4d1b-9cf3-49f1fb294853	2fc2d89c-126c-4a1f-987f-aa357fc63c67	g.chr22:43821099G>A	ENST00000417669.1	+	2	552	c.108G>A	c.(106-108)cgG>cgA	p.R36R	MPPED1_ENST00000414469.2_Intron|MPPED1_ENST00000538182.1_Silent_p.R69R|MPPED1_ENST00000439548.1_Intron|MPPED1_ENST00000542779.1_Silent_p.R36R|MPPED1_ENST00000443721.1_Silent_p.R36R			O15442	MPPD1_HUMAN	metallophosphoesterase domain containing 1	36							hydrolase activity			endometrium(3)|large_intestine(3)|lung(4)|prostate(2)|skin(1)	13		all_neural(38;0.0244)|Ovarian(80;0.0694)				TGGCCGCTCGGCGGCACCAGC	0.662000													22	18					0	0	1	0	0
TSHZ3	57616	broad.mit.edu	37	19	31768091	31768091	+	Missense_Mutation	SNP	C	C	T			TCGA-E1-A7Z2-01A-21D-A34J-08	TCGA-E1-A7Z2-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53d89c8c-9732-4d1b-9cf3-49f1fb294853	2fc2d89c-126c-4a1f-987f-aa357fc63c67	g.chr19:31768091C>T	ENST00000240587.4	-	2	2935	c.2608G>A	c.(2608-2610)Gag>Aag	p.E870K		NM_020856.2	NP_065907.2	Q63HK5	TSH3_HUMAN	teashirt zinc finger homeobox 3	870					negative regulation of transcription, DNA-dependent|regulation of respiratory gaseous exchange by neurological system process	growth cone|nucleus	chromatin binding|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(4)|endometrium(15)|kidney(9)|large_intestine(20)|lung(60)|ovary(4)|pancreas(2)|prostate(4)|skin(5)	123	Esophageal squamous(110;0.226)					TCAGACTTCTCGGAGATGCTG	0.572000													42	77					0	0	1	0	0
GAL3ST3	89792	broad.mit.edu	37	11	65810541	65810541	+	Missense_Mutation	SNP	C	C	T			TCGA-E1-A7Z2-01A-21D-A34J-08	TCGA-E1-A7Z2-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53d89c8c-9732-4d1b-9cf3-49f1fb294853	2fc2d89c-126c-4a1f-987f-aa357fc63c67	g.chr11:65810541C>T	ENST00000312006.4	-	3	1014	c.733G>A	c.(733-735)Gac>Aac	p.D245N	GAL3ST3_ENST00000527878.1_Missense_Mutation_p.D245N	NM_033036.2	NP_149025.1	Q96A11	G3ST3_HUMAN	galactose-3-O-sulfotransferase 3	245					monosaccharide metabolic process|oligosaccharide metabolic process|poly-N-acetyllactosamine metabolic process|proteoglycan biosynthetic process|sulfur compound metabolic process	Golgi cisterna membrane|integral to membrane	3'-phosphoadenosine 5'-phosphosulfate binding|carbohydrate binding|galactosylceramide sulfotransferase activity|proteoglycan sulfotransferase activity			kidney(1)|lung(9)|ovary(2)|skin(2)	14						AGCGACTCGTCGAAGTACTCG	0.692000													35	46					0	0	1	0	0
ANKRD30B	374860	broad.mit.edu	37	18	14850370	14850370	+	Missense_Mutation	SNP	A	A	G			TCGA-E1-A7Z2-01A-21D-A34J-08	TCGA-E1-A7Z2-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53d89c8c-9732-4d1b-9cf3-49f1fb294853	2fc2d89c-126c-4a1f-987f-aa357fc63c67	g.chr18:14850370A>G	ENST00000358984.4	+	35	3376	c.3196A>G	c.(3196-3198)Aat>Gat	p.N1066D		NM_001145029.1	NP_001138501.1	Q9BXX2	AN30B_HUMAN	ankyrin repeat domain 30B	1151										breast(3)|endometrium(4)|kidney(3)|lung(8)|ovary(1)|prostate(2)|skin(1)	22						TGTAACAAGTAATTTGAATCA	0.289000													4	11					0	0	1	0	0
CUX1	1523	broad.mit.edu	37	7	101459365	101459365	+	Nonsense_Mutation	SNP	C	C	T			TCGA-E1-A7Z2-01A-21D-A34J-08	TCGA-E1-A7Z2-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53d89c8c-9732-4d1b-9cf3-49f1fb294853	2fc2d89c-126c-4a1f-987f-aa357fc63c67	g.chr7:101459365C>T	ENST00000360264.3	+	1	75	c.55C>T	c.(55-57)Cag>Tag	p.Q19*	CUX1_ENST00000547394.2_Nonsense_Mutation_p.Q19*|CUX1_ENST00000292538.4_Nonsense_Mutation_p.Q19*|CUX1_ENST00000425244.2_Nonsense_Mutation_p.Q19*|CUX1_ENST00000437600.4_Nonsense_Mutation_p.Q19*|CUX1_ENST00000393824.3_Nonsense_Mutation_p.Q19*	NM_001202543.1	NP_001189472.1	P39880	CUX1_HUMAN	cut-like homeobox 1	8					negative regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|central_nervous_system(1)|cervix(2)|endometrium(6)|kidney(3)|large_intestine(8)|lung(26)|ovary(7)|pancreas(1)|prostate(6)|skin(2)|stomach(1)|urinary_tract(5)	70						TGATTTACAGCAGCTGCAGGT	0.672000													64	26					0	0	1	0	0
FAM86JP	0	broad.mit.edu	37	3	125647396	125647396	+	RNA	SNP	T	T	C			TCGA-E1-A7Z2-01A-21D-A34J-08	TCGA-E1-A7Z2-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53d89c8c-9732-4d1b-9cf3-49f1fb294853	2fc2d89c-126c-4a1f-987f-aa357fc63c67	g.chr3:125647396T>C	ENST00000485843.1	+	0	541					NR_024251.1																						TGTTTCCCTATGAAGAGCACT	0.502000													4	140					0	0	1	0	0
XRCC2	7516	broad.mit.edu	37	7	152345781	152345781	+	Missense_Mutation	SNP	G	G	C			TCGA-E1-A7Z2-01A-21D-A34J-08	TCGA-E1-A7Z2-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53d89c8c-9732-4d1b-9cf3-49f1fb294853	2fc2d89c-126c-4a1f-987f-aa357fc63c67	g.chr7:152345781G>C	ENST00000359321.1	-	3	874	c.789C>G	c.(787-789)aaC>aaG	p.N263K	XRCC2_ENST00000495707.1_5'UTR	NM_005431.1	NP_005422.1	O43543	XRCC2_HUMAN	X-ray repair complementing defective repair in Chinese hamster cells 2	263					meiosis	nucleus	ATP binding|DNA binding|DNA-dependent ATPase activity			NS(1)|breast(1)|large_intestine(5)|liver(1)|lung(1)|prostate(2)	11		all_hematologic(28;0.0592)|Prostate(32;0.081)	OV - Ovarian serous cystadenocarcinoma(82;0.0423)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0429)		TTTTTAAACTGTTACTTTTTA	0.333000								Homologous recombination					27	51					0	0	1	0	0
MAP3K19	80122	broad.mit.edu	37	2	135782204	135782204	+	Missense_Mutation	SNP	G	G	A			TCGA-E1-A7Z2-01A-21D-A34J-08	TCGA-E1-A7Z2-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53d89c8c-9732-4d1b-9cf3-49f1fb294853	2fc2d89c-126c-4a1f-987f-aa357fc63c67	g.chr2:135782204G>A	ENST00000375845.3	-	1	44	c.14C>T	c.(13-15)cCa>cTa	p.P5L	MAP3K19_ENST00000392917.3_Missense_Mutation_p.P5L|MAP3K19_ENST00000392918.3_Missense_Mutation_p.P5L|MAP3K19_ENST00000358371.4_Missense_Mutation_p.P5L|MAP3K19_ENST00000375844.3_Missense_Mutation_p.P5L	NM_025052.3	NP_079328.3			mitogen-activated protein kinase kinase kinase 19																		ACCTGGTTTTGGCATAGAACT	0.333000													36	82					0	0	1	0	0
TMEM105	284186	broad.mit.edu	37	17	79288241	79288241	+	Missense_Mutation	SNP	C	C	T			TCGA-E1-A7Z2-01A-21D-A34J-08	TCGA-E1-A7Z2-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53d89c8c-9732-4d1b-9cf3-49f1fb294853	2fc2d89c-126c-4a1f-987f-aa357fc63c67	g.chr17:79288241C>T	ENST00000332900.1	-	2	571	c.22G>A	c.(22-24)Gcg>Acg	p.A8T		NM_178520.3	NP_848615.1	Q8N8V8	TM105_HUMAN	transmembrane protein 105	8						integral to membrane				NS(1)|large_intestine(3)|lung(1)|ovary(2)	7	all_neural(118;0.0804)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0272)|OV - Ovarian serous cystadenocarcinoma(97;0.0892)			TTCAAGGACGCCCTCCTCACC	0.647000													13	13					0	0	1	0	0
PTPRG	5793	broad.mit.edu	37	3	62153675	62153675	+	Missense_Mutation	SNP	G	G	A			TCGA-E1-A7Z2-01A-21D-A34J-08	TCGA-E1-A7Z2-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53d89c8c-9732-4d1b-9cf3-49f1fb294853	2fc2d89c-126c-4a1f-987f-aa357fc63c67	g.chr3:62153675G>A	ENST00000474889.1	+	8	1248	c.871G>A	c.(871-873)Gag>Aag	p.E291K	PTPRG_ENST00000295874.10_Missense_Mutation_p.E291K	NM_002841.3	NP_002832.3	P23470	PTPRG_HUMAN	protein tyrosine phosphatase, receptor type, G	291	Alpha-carbonic anhydrase.				transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	identical protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(4)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(12)|liver(2)|lung(15)|ovary(7)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	62				BRCA - Breast invasive adenocarcinoma(55;0.000376)|KIRC - Kidney renal clear cell carcinoma(10;0.0499)|Kidney(10;0.065)		CTTCACCACGGAGCAGCAAGA	0.478000													40	84					0	0	1	0	0
CDON	50937	broad.mit.edu	37	11	125887050	125887050	+	Silent	SNP	G	G	A			TCGA-E1-A7Z2-01A-21D-A34J-08	TCGA-E1-A7Z2-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53d89c8c-9732-4d1b-9cf3-49f1fb294853	2fc2d89c-126c-4a1f-987f-aa357fc63c67	g.chr11:125887050G>A	ENST00000392693.3	-	6	988	c.861C>T	c.(859-861)aaC>aaT	p.N287N	CDON_ENST00000263577.7_Silent_p.N287N	NM_001243597.1|NM_016952.4	NP_001230526.1|NP_058648.4	Q4KMG0	CDON_HUMAN	cell adhesion associated, oncogene regulated	287	Ig-like C2-type 3.				cell adhesion|muscle cell differentiation|positive regulation of muscle cell differentiation	integral to membrane|plasma membrane	protein binding			breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(22)|lung(9)|ovary(3)|prostate(2)|skin(4)|stomach(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	61	all_hematologic(175;0.177)	Breast(109;0.00157)|Lung NSC(97;0.0127)|all_lung(97;0.0133)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.51e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0604)		TGCAGGAATAGTTTCCGGAGT	0.428000													28	43					0	0	1	0	0
RNF113B	140432	broad.mit.edu	37	13	98828793	98828793	+	Missense_Mutation	SNP	C	C	A			TCGA-E1-A7Z2-01A-21D-A34J-08	TCGA-E1-A7Z2-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53d89c8c-9732-4d1b-9cf3-49f1fb294853	2fc2d89c-126c-4a1f-987f-aa357fc63c67	g.chr13:98828793C>A	ENST00000267291.6	-	1	726	c.698G>T	c.(697-699)gGt>gTt	p.G233V	FARP1_ENST00000595437.1_Intron|FARP1_ENST00000319562.6_Intron|FARP1_ENST00000376581.5_Intron|FARP1_ENST00000376586.2_Intron	NM_178861.4	NP_849192.1	Q8IZP6	R113B_HUMAN	ring finger protein 113B	233							nucleic acid binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(3)|large_intestine(3)|lung(3)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	18	all_neural(89;0.101)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)		BRCA - Breast invasive adenocarcinoma(86;0.13)			ACAGTAGCGACCCTCTTCAAG	0.527000													25	54					3.08376e-08	3.39843e-08	1	1	0
SHCBP1	79801	broad.mit.edu	37	16	46655218	46655218	+	Silent	SNP	C	C	T			TCGA-E1-A7Z2-01A-21D-A34J-08	TCGA-E1-A7Z2-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53d89c8c-9732-4d1b-9cf3-49f1fb294853	2fc2d89c-126c-4a1f-987f-aa357fc63c67	g.chr16:46655218C>T	ENST00000303383.3	-	1	320	c.54G>A	c.(52-54)ccG>ccA	p.P18P	SHCBP1_ENST00000564272.1_5'UTR	NM_024745.4	NP_079021.3	Q8NEM2	SHCBP_HUMAN	SHC SH2-domain binding protein 1	18										breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(7)|ovary(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	28		all_cancers(37;0.00404)|all_epithelial(9;0.00527)|all_lung(18;0.0413)|Lung NSC(13;0.213)				CCATGCGCTCCGGCGCCATGG	0.697000													24	39					0	0	1	0	0
NEK6	10783	broad.mit.edu	37	9	127074826	127074826	+	Silent	SNP	G	G	A			TCGA-E1-A7Z2-01A-21D-A34J-08	TCGA-E1-A7Z2-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53d89c8c-9732-4d1b-9cf3-49f1fb294853	2fc2d89c-126c-4a1f-987f-aa357fc63c67	g.chr9:127074826G>A	ENST00000373600.3	+	4	446	c.231G>A	c.(229-231)gcG>gcA	p.A77A	NEK6_ENST00000539416.1_Silent_p.A68A|NEK6_ENST00000545174.1_Silent_p.A43A|NEK6_ENST00000546191.1_Silent_p.A43A|NEK6_ENST00000394199.2_Silent_p.A77A|NEK6_ENST00000540326.1_Silent_p.A61A|NEK6_ENST00000320246.5_Silent_p.A43A|NEK6_ENST00000373603.1_Silent_p.A43A	NM_001145001.2	NP_001138473.1	Q9HC98	NEK6_HUMAN	NIMA-related kinase 6	43	Protein kinase.				apoptosis|cell division|chromosome segregation|mitosis|peptidyl-serine phosphorylation|positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of mitotic metaphase/anaphase transition	cytoplasm|nucleus	ATP binding|kinesin binding|magnesium ion binding|protein kinase binding|protein serine/threonine kinase activity|signal transducer activity			endometrium(1)|kidney(1)|large_intestine(4)|lung(4)|ovary(2)|prostate(1)|skin(1)|stomach(1)	15						GCTCGCTGGCGGACTTCCAGA	0.612000													13	37					0	0	1	0	0
NAPSA	9476	broad.mit.edu	37	19	50862030	50862030	+	Missense_Mutation	SNP	C	C	T			TCGA-E1-A7Z2-01A-21D-A34J-08	TCGA-E1-A7Z2-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53d89c8c-9732-4d1b-9cf3-49f1fb294853	2fc2d89c-126c-4a1f-987f-aa357fc63c67	g.chr19:50862030C>T	ENST00000253719.2	-	9	1251	c.1043G>A	c.(1042-1044)cGa>cAa	p.R348Q	NR1H2_ENST00000542413.1_Intron|NR1H2_ENST00000600978.1_Intron	NM_004851.1	NP_004842.1	O96009	NAPSA_HUMAN	napsin A aspartic peptidase	348					proteolysis	extracellular region	aspartic-type endopeptidase activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(4)|skin(3)	12		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00743)|GBM - Glioblastoma multiforme(134;0.0183)		GACGCCATTTCGAGTAGTCTG	0.622000													7	15					0	0	1	0	0
PLXNB3	5365	broad.mit.edu	37	X	153033031	153033031	+	Missense_Mutation	SNP	G	G	A			TCGA-E1-A7Z2-01A-21D-A34J-08	TCGA-E1-A7Z2-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53d89c8c-9732-4d1b-9cf3-49f1fb294853	2fc2d89c-126c-4a1f-987f-aa357fc63c67	g.chrX:153033031G>A	ENST00000538966.1	+	4	1089	c.818G>A	c.(817-819)cGc>cAc	p.R273H	PLXNB3_ENST00000538282.1_Intron|PLXNB3_ENST00000361971.5_Missense_Mutation_p.R250H|PLXNB3_ENST00000538776.1_Intron|PLXNB3_ENST00000538543.1_Intron	NM_001163257.1	NP_001156729.1	Q9ULL4	PLXB3_HUMAN	plexin B3	250	Sema.				axon guidance	integral to membrane|intracellular|plasma membrane	protein binding|receptor activity			central_nervous_system(1)|endometrium(7)|large_intestine(2)|lung(15)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	32	all_hematologic(71;4.25e-06)|all_lung(58;3.83e-05)|Lung NSC(58;5.54e-05)|Acute lymphoblastic leukemia(192;6.56e-05)					GTGTTccgccgccgcggggcc	0.706000													8	13					0	0	1	0	0
TSHZ3	57616	broad.mit.edu	37	19	31769601	31769601	+	Silent	SNP	G	G	A			TCGA-E1-A7Z2-01A-21D-A34J-08	TCGA-E1-A7Z2-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53d89c8c-9732-4d1b-9cf3-49f1fb294853	2fc2d89c-126c-4a1f-987f-aa357fc63c67	g.chr19:31769601G>A	ENST00000240587.4	-	2	1425	c.1098C>T	c.(1096-1098)taC>taT	p.Y366Y		NM_020856.2	NP_065907.2	Q63HK5	TSH3_HUMAN	teashirt zinc finger homeobox 3	366					negative regulation of transcription, DNA-dependent|regulation of respiratory gaseous exchange by neurological system process	growth cone|nucleus	chromatin binding|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding	p.Y366_G367>*(1)|p.Y183_G184>*(1)		breast(4)|endometrium(15)|kidney(9)|large_intestine(20)|lung(60)|ovary(4)|pancreas(2)|prostate(4)|skin(5)	123	Esophageal squamous(110;0.226)					TCTGGTGGCCGTACCGATTAT	0.562000													75	150					0	0	1	0	0
ANKRD30A	91074	broad.mit.edu	37	10	37430975	37430975	+	Missense_Mutation	SNP	G	G	A			TCGA-E1-A7Z2-01A-21D-A34J-08	TCGA-E1-A7Z2-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53d89c8c-9732-4d1b-9cf3-49f1fb294853	2fc2d89c-126c-4a1f-987f-aa357fc63c67	g.chr10:37430975G>A	ENST00000374660.1	+	7	1081	c.982G>A	c.(982-984)Gca>Aca	p.A328T	ANKRD30A_ENST00000602533.1_Missense_Mutation_p.A328T|ANKRD30A_ENST00000361713.1_Missense_Mutation_p.A328T			Q9BXX3	AN30A_HUMAN	ankyrin repeat domain 30A	384						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(8)|endometrium(14)|kidney(21)|large_intestine(13)|lung(70)|ovary(8)|pancreas(1)|prostate(3)|skin(15)|stomach(1)|urinary_tract(3)	158						TAGGAAGATCGCATGGGAGAA	0.433000													5	72					0	0	1	0	0
RIMS2	9699	broad.mit.edu	37	8	105261789	105261789	+	Missense_Mutation	SNP	G	G	T			TCGA-E1-A7Z2-01A-21D-A34J-08	TCGA-E1-A7Z2-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53d89c8c-9732-4d1b-9cf3-49f1fb294853	2fc2d89c-126c-4a1f-987f-aa357fc63c67	g.chr8:105261789G>T	ENST00000507740.1	+	20	3342	c.3106G>T	c.(3106-3108)Gta>Tta	p.V1036L	RIMS2_ENST00000339750.2_Missense_Mutation_p.V158L|RIMS2_ENST00000262231.10_Missense_Mutation_p.V1061L|RIMS2_ENST00000406091.3_Missense_Mutation_p.V1222L|RIMS2_ENST00000436393.2_Missense_Mutation_p.V1240L	NM_014677.4	NP_055492.3	Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	1284					intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			NS(1)|breast(4)|central_nervous_system(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(22)|liver(1)|lung(68)|ovary(6)|pancreas(2)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(10)|urinary_tract(1)	144			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			TGGCCTTGTTGTAAAACCAGG	0.403000										HNSCC(12;0.0054)			10	29					0.00829132	0.00829132	1	1	0
OBSCN	84033	broad.mit.edu	37	1	228471427	228471427	+	Silent	SNP	C	C	T			TCGA-E1-A7Z2-01A-21D-A34J-08	TCGA-E1-A7Z2-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53d89c8c-9732-4d1b-9cf3-49f1fb294853	2fc2d89c-126c-4a1f-987f-aa357fc63c67	g.chr1:228471427C>T	ENST00000570156.2	+	38	10322	c.10248C>T	c.(10246-10248)tgC>tgT	p.C3416C	OBSCN_ENST00000366707.4_Silent_p.C106C|OBSCN_ENST00000359599.6_Silent_p.C1834C|OBSCN_ENST00000422127.1_Silent_p.C2987C|OBSCN_ENST00000284548.11_Silent_p.C2987C|OBSCN_ENST00000366709.4_Silent_p.C106C	NM_001271223.2	NP_001258152.2	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	2451	Ig-like 34.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding	p.C3270C(1)|p.C3041C(1)		NS(2)|breast(7)|central_nervous_system(5)|cervix(2)|endometrium(30)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(37)|lung(89)|ovary(8)|pancreas(3)|prostate(13)|skin(6)|stomach(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	223		Prostate(94;0.0405)				CCTATACCTGCGACATTGGCC	0.647000													32	77					0	0	1	0	0
SLC25A39	51629	broad.mit.edu	37	17	42400907	42400907	+	Silent	SNP	G	G	A			TCGA-E1-A7Z2-01A-21D-A34J-08	TCGA-E1-A7Z2-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53d89c8c-9732-4d1b-9cf3-49f1fb294853	2fc2d89c-126c-4a1f-987f-aa357fc63c67	g.chr17:42400907G>A	ENST00000225308.8	-	2	198	c.24C>T	c.(22-24)ggC>ggT	p.G8G	SLC25A39_ENST00000590194.1_Silent_p.G8G|SLC25A39_ENST00000537904.2_Silent_p.G8G|SLC25A39_ENST00000377095.5_Silent_p.G8G|SLC25A39_ENST00000586016.1_Intron	NM_016016.2	NP_057100.1	Q9BZJ4	S2539_HUMAN	solute carrier family 25, member 39	8					heme biosynthetic process|transport	integral to membrane|mitochondrial inner membrane				endometrium(2)|lung(3)|prostate(1)|upper_aerodigestive_tract(1)	7		Prostate(33;0.0233)		BRCA - Breast invasive adenocarcinoma(366;0.189)		GGGGGCTGATGCCCGCAGGGT	0.607000													4	4					0	0	1	0	0
KCNS3	3790	broad.mit.edu	37	2	18112378	18112378	+	Missense_Mutation	SNP	C	C	T			TCGA-E1-A7Z2-01A-21D-A34J-08	TCGA-E1-A7Z2-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53d89c8c-9732-4d1b-9cf3-49f1fb294853	2fc2d89c-126c-4a1f-987f-aa357fc63c67	g.chr2:18112378C>T	ENST00000403915.1	+	3	554	c.103C>T	c.(103-105)Cgg>Tgg	p.R35W	KCNS3_ENST00000304101.4_Missense_Mutation_p.R35W|KCNS3_ENST00000465292.1_Intron			Q9BQ31	KCNS3_HUMAN	potassium voltage-gated channel, delayed-rectifier, subfamily S, member 3	35					energy reserve metabolic process|regulation of insulin secretion	Golgi apparatus|voltage-gated potassium channel complex	delayed rectifier potassium channel activity|potassium channel regulator activity			endometrium(5)|kidney(1)|large_intestine(7)|lung(11)|ovary(4)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	32	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.158)					CACCCTCCTGCGGTTTCCTCA	0.512000													40	77					0	0	1	0	0
RASGEF1C	255426	broad.mit.edu	37	5	179563505	179563505	+	Missense_Mutation	SNP	C	C	T			TCGA-E1-A7Z2-01A-21D-A34J-08	TCGA-E1-A7Z2-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53d89c8c-9732-4d1b-9cf3-49f1fb294853	2fc2d89c-126c-4a1f-987f-aa357fc63c67	g.chr5:179563505C>T	ENST00000393371.2	-	3	607	c.311G>A	c.(310-312)cGg>cAg	p.R104Q	RASGEF1C_ENST00000522500.1_5'UTR|RASGEF1C_ENST00000361132.4_Missense_Mutation_p.R104Q			Q8N431	RGF1C_HUMAN	RasGEF domain family, member 1C	104	N-terminal Ras-GEF.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	intracellular	guanyl-nucleotide exchange factor activity			breast(1)|kidney(2)|large_intestine(3)|lung(3)|ovary(1)|prostate(1)|stomach(1)	12	all_cancers(89;3.44e-05)|all_epithelial(37;1.22e-05)|Renal(175;0.000269)|Lung NSC(126;0.00199)|all_lung(126;0.00351)|Breast(19;0.137)	all_cancers(40;0.0242)|Medulloblastoma(196;0.00498)|all_neural(177;0.0137)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			GCCGAACTTCCGGACCCGGGC	0.687000													5	7					0	0	1	0	0
EGFR	1956	broad.mit.edu	37	7	55210075	55210075	+	Missense_Mutation	SNP	T	T	G			TCGA-E1-A7Z2-01A-21D-A34J-08	TCGA-E1-A7Z2-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53d89c8c-9732-4d1b-9cf3-49f1fb294853	2fc2d89c-126c-4a1f-987f-aa357fc63c67	g.chr7:55210075T>G	ENST00000275493.2	+	2	362	c.185T>G	c.(184-186)cTt>cGt	p.L62R	EGFR_ENST00000442591.1_Missense_Mutation_p.L62R|EGFR_ENST00000454757.2_Missense_Mutation_p.L9R|EGFR_ENST00000420316.2_Missense_Mutation_p.L62R|EGFR_ENST00000342916.3_Missense_Mutation_p.L62R|EGFR_ENST00000455089.1_Missense_Mutation_p.L62R|EGFR_ENST00000344576.2_Missense_Mutation_p.L62R	NM_005228.3	NP_005219.2	P00533	EGFR_HUMAN	epidermal growth factor receptor	62					activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.L62R(3)		NS(2)|adrenal_gland(5)|biliary_tract(8)|bone(3)|breast(18)|central_nervous_system(106)|endometrium(26)|eye(3)|haematopoietic_and_lymphoid_tissue(9)|kidney(11)|large_intestine(85)|liver(2)|lung(13575)|oesophagus(21)|ovary(38)|pancreas(3)|peritoneum(11)|pleura(2)|prostate(35)|salivary_gland(11)|skin(9)|small_intestine(1)|soft_tissue(4)|stomach(41)|thymus(2)|thyroid(14)|upper_aerodigestive_tract(59)|urinary_tract(6)	14110	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	GAGGTGGTCCTTGGGAATTTG	0.408000		8	"""A, O, Mis"""		"""glioma, NSCLC"""	NSCLC			Lung Cancer, Familial Clustering of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			44	167					0	0	1	0	0
SLC6A4	6532	broad.mit.edu	37	17	28537613	28537613	+	Missense_Mutation	SNP	C	C	T			TCGA-E1-A7Z2-01A-21D-A34J-08	TCGA-E1-A7Z2-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53d89c8c-9732-4d1b-9cf3-49f1fb294853	2fc2d89c-126c-4a1f-987f-aa357fc63c67	g.chr17:28537613C>T	ENST00000401766.2	-	10	1881	c.1369G>A	c.(1369-1371)Gtc>Atc	p.V457I	SLC6A4_ENST00000261707.3_Missense_Mutation_p.V457I			P31645	SC6A4_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 4	457					response to toxin|serotonin uptake|thalamus development	cytosol|endomembrane system|endosome membrane|membrane raft	actin filament binding|Rab GTPase binding|serotonin transmembrane transporter activity|serotonin:sodium symporter activity	p.V457I(1)		breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(8)|ovary(1)|prostate(1)|skin(4)	25					Amineptine(DB04836)|Amitriptyline(DB00321)|Amoxapine(DB00543)|Citalopram(DB00215)|Clomipramine(DB01242)|Cocaine(DB00907)|Desipramine(DB01151)|Dexfenfluramine(DB01191)|Dextromethorphan(DB00514)|Doxepin(DB01142)|Duloxetine(DB00476)|Escitalopram(DB01175)|Fluoxetine(DB00472)|Fluvoxamine(DB00176)|Imipramine(DB00458)|Methylphenidate(DB00422)|Milnacipran(DB04896)|Minaprine(DB00805)|Nefazodone(DB01149)|Nortriptyline(DB00540)|Paroxetine(DB00715)|Phentermine(DB00191)|Protriptyline(DB00344)|Sertraline(DB01104)|Sibutramine(DB01105)|Tegaserod(DB01079)|Tramadol(DB00193)|Trazodone(DB00656)|Trimipramine(DB00726)|Venlafaxine(DB00285)|Zimelidine(DB04832)	TTGGCCCAGACGTGTGGGAAC	0.597000													25	62					0	0	1	0	0
SPEG	10290	broad.mit.edu	37	2	220313697	220313697	+	Translation_Start_Site	DEL	A	A	-			TCGA-E1-A7Z2-01A-21D-A34J-08	TCGA-E1-A7Z2-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53d89c8c-9732-4d1b-9cf3-49f1fb294853	2fc2d89c-126c-4a1f-987f-aa357fc63c67	g.chr2:220313697delA	ENST00000396695.2	+	0	1342				SPEG_ENST00000312358.7_Frame_Shift_Del_p.E606fs|SPEG_ENST00000485813.1_3'UTR|SPEG_ENST00000396698.1_Frame_Shift_Del_p.E502fs			Q15772	SPEG_HUMAN	SPEG complex locus						muscle organ development|negative regulation of cell proliferation	nucleus	ATP binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(3)|endometrium(10)|kidney(2)|large_intestine(9)|lung(42)|ovary(5)|pancreas(1)|prostate(8)|skin(1)|stomach(9)|upper_aerodigestive_tract(4)|urinary_tract(4)	100		Renal(207;0.0183)		Epithelial(149;4.5e-10)|all cancers(144;7.93e-08)|Lung(261;0.00639)|LUSC - Lung squamous cell carcinoma(224;0.00829)|READ - Rectum adenocarcinoma(5;0.163)		GCCATCCAGGAGTGCAGGAGC	0.756													2	4	---	---	---	---					
KMT2C	58508	broad.mit.edu	37	7	151859576	151859576	+	Frame_Shift_Del	DEL	G	G	-			TCGA-E1-A7Z2-01A-21D-A34J-08	TCGA-E1-A7Z2-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53d89c8c-9732-4d1b-9cf3-49f1fb294853	2fc2d89c-126c-4a1f-987f-aa357fc63c67	g.chr7:151859576delG	ENST00000355193.2	-	43	11304	c.11086delC	c.(11086-11088)aafs	p.Q3697fs	KMT2C_ENST00000262189.6_Frame_Shift_Del_p.Q3697fs					lysine (K)-specific methyltransferase 2C																		TACGTCTGTTGATTTGGAGTT	0.468													112	234	---	---	---	---					
ELMOD1	55531	broad.mit.edu	37	11	107521064	107521064	+	Frame_Shift_Del	DEL	T	T	-			TCGA-E1-A7Z2-01A-21D-A34J-08	TCGA-E1-A7Z2-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53d89c8c-9732-4d1b-9cf3-49f1fb294853	2fc2d89c-126c-4a1f-987f-aa357fc63c67	g.chr11:107521064delT	ENST00000265840.7	+	8	823	c.558delT	c.(556-558)tafs	p.Y186fs	ELMOD1_ENST00000531234.1_Frame_Shift_Del_p.Y180fs|ELMOD1_ENST00000443271.2_Frame_Shift_Del_p.Y186fs	NM_018712.3	NP_061182.3	Q8N336	ELMD1_HUMAN	ELMO/CED-12 domain containing 1	186	ELMO.				phagocytosis	cytoskeleton	GTPase activator activity			endometrium(2)|large_intestine(5)|liver(2)|lung(7)|pancreas(2)|prostate(1)	19		Melanoma(852;0.000288)|Acute lymphoblastic leukemia(157;0.000966)|all_hematologic(158;0.00301)|all_epithelial(67;0.00304)|Breast(348;0.104)		BRCA - Breast invasive adenocarcinoma(274;3.4e-05)|Epithelial(105;0.00027)|all cancers(92;0.00481)		GCTGCAGGTATTTCGCGGAAA	0.413													2	4	---	---	---	---					
CDC27	996	broad.mit.edu	37	17	45219612	45219612	+	Frame_Shift_Del	DEL	A	A	-			TCGA-E1-A7Z2-01A-21D-A34J-08	TCGA-E1-A7Z2-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53d89c8c-9732-4d1b-9cf3-49f1fb294853	2fc2d89c-126c-4a1f-987f-aa357fc63c67	g.chr17:45219612delA	ENST00000066544.3	-	11	1454	c.1361delT	c.(1360-1362)cafs	p.L454fs	CDC27_ENST00000527547.1_Frame_Shift_Del_p.L454fs|CDC27_ENST00000446365.2_Frame_Shift_Del_p.L393fs|CDC27_ENST00000531206.1_Frame_Shift_Del_p.L460fs	NM_001114091.1|NM_001256.3	NP_001107563.1|NP_001247.3	P30260	CDC27_HUMAN	cell division cycle 27	454					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell proliferation|mitotic cell cycle spindle assembly checkpoint|mitotic metaphase/anaphase transition|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination	anaphase-promoting complex|centrosome|cytosol|nucleoplasm|spindle microtubule	protein phosphatase binding			NS(1)|breast(5)|central_nervous_system(3)|cervix(1)|endometrium(2)|kidney(17)|large_intestine(18)|lung(11)|ovary(5)|pancreas(1)|prostate(19)|skin(5)|upper_aerodigestive_tract(2)	90						TGCTTTTTGTAGATTAAAGGC	0.308													7	38	---	---	---	---					
SLC25A10	1468	broad.mit.edu	37	17	79682008	79682008	+	Frame_Shift_Del	DEL	T	T	-			TCGA-E1-A7Z2-01A-21D-A34J-08	TCGA-E1-A7Z2-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	53d89c8c-9732-4d1b-9cf3-49f1fb294853	2fc2d89c-126c-4a1f-987f-aa357fc63c67	g.chr17:79682008delT	ENST00000331531.5	+	2	239	c.119delT	c.(118-120)ggfs	p.V40fs	SLC25A10_ENST00000350690.5_Frame_Shift_Del_p.V40fs|SLC25A10_ENST00000545862.1_5'UTR|SLC25A10_ENST00000541223.1_Frame_Shift_Del_p.V195fs|SLC25A10_ENST00000571730.1_Frame_Shift_Del_p.V195fs	NM_001270888.1	NP_001257817.1	Q9UBX3	DIC_HUMAN	solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10	40					gluconeogenesis|mitochondrial transport	integral to membrane|mitochondrial inner membrane|nucleus	protein binding			endometrium(1)|lung(9)|ovary(1)|prostate(1)|skin(2)	14	all_neural(118;0.0878)|Ovarian(332;0.12)|all_lung(278;0.23)		BRCA - Breast invasive adenocarcinoma(99;0.0117)|OV - Ovarian serous cystadenocarcinoma(97;0.0955)		Succinic acid(DB00139)	CAGCAGGAGGTGAAGCTGCGC	0.657													9	38	---	---	---	---