Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
BPIFB4	149954	broad.mit.edu	37	20	31671236	31671236	+	Missense_Mutation	SNP	G	G	A			TCGA-DU-A7TB-01A-11D-A33T-08	TCGA-DU-A7TB-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7095551c-6180-4cf2-a64a-a51c721f3cd7	97caf281-250f-404a-b54f-adf3225062c4	g.chr20:31671236G>A	ENST00000375483.3	+	3	233	c.233G>A	c.(232-234)gGc>gAc	p.G78D		NM_182519.2	NP_872325.2	P59827	LPLC4_HUMAN	BPI fold containing family B, member 4	78						cytoplasm|extracellular region	lipid binding										TATACCAACGGCAAAAAACTT	0.478000													4	219					0	0	1	0	0
RP11-480I12.7	0	broad.mit.edu	37	1	202843376	202843376	+	RNA	SNP	C	C	T			TCGA-DU-A7TB-01A-11D-A33T-08	TCGA-DU-A7TB-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7095551c-6180-4cf2-a64a-a51c721f3cd7	97caf281-250f-404a-b54f-adf3225062c4	g.chr1:202843376C>T	ENST00000456105.2	+	0	1328					NR_002929.2																						CCATCCTGGCCGCCTTCCAGC	0.537000													10	27					0	0	1	0	0
SLC25A10	1468	broad.mit.edu	37	17	79682550	79682550	+	Missense_Mutation	SNP	C	C	T			TCGA-DU-A7TB-01A-11D-A33T-08	TCGA-DU-A7TB-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7095551c-6180-4cf2-a64a-a51c721f3cd7	97caf281-250f-404a-b54f-adf3225062c4	g.chr17:79682550C>T	ENST00000331531.5	+	3	376	c.256C>T	c.(256-258)Cgg>Tgg	p.R86W	SLC25A10_ENST00000545862.1_Missense_Mutation_p.R43W|SLC25A10_ENST00000541223.1_Missense_Mutation_p.R241W|SLC25A10_ENST00000350690.5_Missense_Mutation_p.R86W|SLC25A10_ENST00000571730.1_Missense_Mutation_p.R241W	NM_001270888.1	NP_001257817.1	Q9UBX3	DIC_HUMAN	solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10	86					gluconeogenesis|mitochondrial transport	integral to membrane|mitochondrial inner membrane|nucleus	protein binding			endometrium(1)|lung(9)|ovary(1)|prostate(1)|skin(2)	14	all_neural(118;0.0878)|Ovarian(332;0.12)|all_lung(278;0.23)		BRCA - Breast invasive adenocarcinoma(99;0.0117)|OV - Ovarian serous cystadenocarcinoma(97;0.0955)		Succinic acid(DB00139)	CGAGACTGTGCGGGACCGTGT	0.697000													5	363					0	0	1	0	0
ARID2	196528	broad.mit.edu	37	12	46231301	46231301	+	Missense_Mutation	SNP	C	C	A			TCGA-DU-A7TB-01A-11D-A33T-08	TCGA-DU-A7TB-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7095551c-6180-4cf2-a64a-a51c721f3cd7	97caf281-250f-404a-b54f-adf3225062c4	g.chr12:46231301C>A	ENST00000334344.6	+	10	1313	c.1141C>A	c.(1141-1143)Ctt>Att	p.L381I	ARID2_ENST00000422737.1_Missense_Mutation_p.L232I|ARID2_ENST00000444670.1_Missense_Mutation_p.L10I|ARID2_ENST00000479608.1_3'UTR	NM_152641.2	NP_689854.2	Q68CP9	ARID2_HUMAN	AT rich interactive domain 2 (ARID, RFX-like)	381					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(7)|central_nervous_system(3)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(21)|liver(20)|lung(34)|ovary(7)|pancreas(1)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	116	Lung SC(27;0.192)|Renal(347;0.236)	Lung NSC(34;0.106)|all_lung(34;0.22)	OV - Ovarian serous cystadenocarcinoma(5;0.00691)	GBM - Glioblastoma multiforme(48;0.0153)		TTTGGGAAATCTTTGCAAAGC	0.323000			"""N, S, F"""		hepatocellular carcinoma								28	162					6.32553e-13	7.19374e-13	1	1	0
OR4M2	390538	broad.mit.edu	37	15	22368774	22368774	+	Missense_Mutation	SNP	G	G	T			TCGA-DU-A7TB-01A-11D-A33T-08	TCGA-DU-A7TB-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7095551c-6180-4cf2-a64a-a51c721f3cd7	97caf281-250f-404a-b54f-adf3225062c4	g.chr15:22368774G>T	ENST00000332663.2	+	1	297	c.199G>T	c.(199-201)Gcc>Tcc	p.A67S	RP11-69H14.6_ENST00000558896.1_RNA	NM_001004719.2	NP_001004719.2	Q8NGB6	OR4M2_HUMAN	olfactory receptor, family 4, subfamily M, member 2	67					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(2)|endometrium(2)|kidney(4)|large_intestine(6)|lung(38)|ovary(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(3)	63		all_cancers(20;1.94e-20)|all_epithelial(15;3.94e-18)|Lung NSC(15;8.53e-15)|all_lung(15;2.87e-14)|Breast(32;0.00519)|Colorectal(260;0.101)	GBM - Glioblastoma multiforme(6;0.124)	all cancers(64;1.64e-11)|Epithelial(43;5.81e-10)|BRCA - Breast invasive adenocarcinoma(123;0.000255)|Kidney(6;0.00736)|KIRC - Kidney renal clear cell carcinoma(6;0.0135)|GBM - Glioblastoma multiforme(186;0.0963)		GGCTAATCTGGCCTTCCTTGA	0.408000													13	1428					0.000274275	0.000279087	1	1	0
GLDN	342035	broad.mit.edu	37	15	51689743	51689743	+	Silent	SNP	C	C	T			TCGA-DU-A7TB-01A-11D-A33T-08	TCGA-DU-A7TB-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7095551c-6180-4cf2-a64a-a51c721f3cd7	97caf281-250f-404a-b54f-adf3225062c4	g.chr15:51689743C>T	ENST00000335449.6	+	6	821	c.765C>T	c.(763-765)agC>agT	p.S255S	GLDN_ENST00000396399.2_Silent_p.S131S	NM_181789.2	NP_861454.2	Q6ZMI3	GLDN_HUMAN	gliomedin	255	Pro-rich.				cell differentiation|nervous system development	collagen|integral to membrane|plasma membrane				central_nervous_system(1)|kidney(2)|large_intestine(4)|lung(6)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	19				all cancers(107;0.00194)|GBM - Glioblastoma multiforme(94;0.00942)		CCCCTGGAAGCAGAAGAGCCA	0.637000													20	53					0	0	1	0	0
KNOP1	400506	broad.mit.edu	37	16	19718262	19718262	+	Silent	SNP	G	G	A			TCGA-DU-A7TB-01A-11D-A33T-08	TCGA-DU-A7TB-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7095551c-6180-4cf2-a64a-a51c721f3cd7	97caf281-250f-404a-b54f-adf3225062c4	g.chr16:19718262G>A	ENST00000219837.7	-	5	1425	c.1347C>T	c.(1345-1347)aaC>aaT	p.N449N	KNOP1_ENST00000568230.1_Silent_p.N128N|AC002550.5_ENST00000565916.1_RNA	NM_001012991.2	NP_001013009.2			lysine-rich nucleolar protein 1																		ACTTGGAAGCGTTCCTGTCAA	0.507000													141	271					0	0	1	0	0
RRH	10692	broad.mit.edu	37	4	110754331	110754331	+	Missense_Mutation	SNP	G	G	A			TCGA-DU-A7TB-01A-11D-A33T-08	TCGA-DU-A7TB-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7095551c-6180-4cf2-a64a-a51c721f3cd7	97caf281-250f-404a-b54f-adf3225062c4	g.chr4:110754331G>A	ENST00000317735.4	+	2	177	c.143G>A	c.(142-144)gGc>gAc	p.G48D		NM_006583.2	NP_006574.1	O14718	OPSX_HUMAN	retinal pigment epithelium-derived rhodopsin homolog	48					phototransduction|protein-chromophore linkage|visual perception	integral to plasma membrane	G-protein coupled receptor activity|photoreceptor activity			endometrium(1)|kidney(1)|large_intestine(4)|lung(4)|ovary(1)|pancreas(1)	12		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.00109)		ATAGTTCTGGGCATCTTCATT	0.353000													12	142					0	0	1	0	0
DTX3L	151636	broad.mit.edu	37	3	122287626	122287626	+	Silent	SNP	A	A	G			TCGA-DU-A7TB-01A-11D-A33T-08	TCGA-DU-A7TB-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7095551c-6180-4cf2-a64a-a51c721f3cd7	97caf281-250f-404a-b54f-adf3225062c4	g.chr3:122287626A>G	ENST00000296161.4	+	3	879	c.690A>G	c.(688-690)gaA>gaG	p.E230E	DTX3L_ENST00000383661.3_Intron	NM_138287.3	NP_612144.1	Q8TDB6	DTX3L_HUMAN	deltex 3-like (Drosophila)	230					histone monoubiquitination|response to DNA damage stimulus	cytoplasm|nucleus	histone binding|ubiquitin-protein ligase activity|zinc ion binding			breast(2)|endometrium(2)|kidney(1)|large_intestine(3)|lung(12)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	24				GBM - Glioblastoma multiforme(114;0.0459)		CCAAGGCAGAACAAAAAAGCA	0.383000													37	66					0	0	1	0	0
HIVEP1	3096	broad.mit.edu	37	6	12122606	12122606	+	Missense_Mutation	SNP	C	C	T			TCGA-DU-A7TB-01A-11D-A33T-08	TCGA-DU-A7TB-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7095551c-6180-4cf2-a64a-a51c721f3cd7	97caf281-250f-404a-b54f-adf3225062c4	g.chr6:12122606C>T	ENST00000379388.2	+	4	2910	c.2578C>T	c.(2578-2580)Cca>Tca	p.P860S		NM_002114.2	NP_002105.2	P15822	ZEP1_HUMAN	human immunodeficiency virus type I enhancer binding protein 1	860					transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|protein binding|zinc ion binding			NS(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(11)|liver(1)|lung(31)|ovary(4)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(3)	90	Breast(50;0.0639)|Ovarian(93;0.0816)	all_hematologic(90;0.117)				TCCTCCTCATCCACTAAGAGG	0.448000													50	208					0	0	1	0	0
SLC26A6	65010	broad.mit.edu	37	3	48669775	48669775	+	Missense_Mutation	SNP	G	G	A			TCGA-DU-A7TB-01A-11D-A33T-08	TCGA-DU-A7TB-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7095551c-6180-4cf2-a64a-a51c721f3cd7	97caf281-250f-404a-b54f-adf3225062c4	g.chr3:48669775G>A	ENST00000358747.6	-	4	675	c.425C>T	c.(424-426)cCg>cTg	p.P142L	SLC26A6_ENST00000337000.8_Intron|SLC26A6_ENST00000420764.2_Missense_Mutation_p.P163L|SLC26A6_ENST00000395550.2_Missense_Mutation_p.P163L|SLC26A6_ENST00000482282.1_5'UTR|SLC26A6_ENST00000383733.3_Missense_Mutation_p.P163L|SLC26A6_ENST00000455886.2_Intron	NM_001040454.1	NP_001035544.1			solute carrier family 26 (anion exchanger), member 6										SLC26A6/PRKAR2A(2)	NS(1)|breast(1)|cervix(1)|endometrium(3)|large_intestine(1)|lung(11)|ovary(1)	19				BRCA - Breast invasive adenocarcinoma(193;0.00029)|KIRC - Kidney renal clear cell carcinoma(197;0.00544)|Kidney(197;0.00609)		CAAGGCCTGCGGGGCCAGGGA	0.597000													21	46					0	0	1	0	0
PPP3CA	5530	broad.mit.edu	37	4	101947178	101947178	+	Silent	SNP	G	G	A			TCGA-DU-A7TB-01A-11D-A33T-08	TCGA-DU-A7TB-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7095551c-6180-4cf2-a64a-a51c721f3cd7	97caf281-250f-404a-b54f-adf3225062c4	g.chr4:101947178G>A	ENST00000394854.3	-	14	2093	c.1410C>T	c.(1408-1410)ttC>ttT	p.F470F	PPP3CA_ENST00000507176.1_Silent_p.F372F|PPP3CA_ENST00000512215.1_Silent_p.F238F|PPP3CA_ENST00000394853.4_Silent_p.F460F|PPP3CA_ENST00000323055.6_Silent_p.F418F|PPP3CA_ENST00000523694.2_Silent_p.F403F	NM_000944.4	NP_000935.1	Q08209	PP2BA_HUMAN	protein phosphatase 3, catalytic subunit, alpha isozyme	470	Inhibitory domain.				protein dephosphorylation	calcineurin complex|cytosol|nucleus	calcium ion binding|calmodulin binding			breast(1)|cervix(1)|endometrium(3)|large_intestine(4)|lung(8)|ovary(1)|skin(1)|urinary_tract(1)	20				OV - Ovarian serous cystadenocarcinoma(123;6.79e-08)		TGGCTTCCTCGAAGCTAGTGA	0.438000													4	199					0	0	1	0	0
BRD3	8019	broad.mit.edu	37	9	136899859	136899859	+	Missense_Mutation	SNP	C	C	T			TCGA-DU-A7TB-01A-11D-A33T-08	TCGA-DU-A7TB-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7095551c-6180-4cf2-a64a-a51c721f3cd7	97caf281-250f-404a-b54f-adf3225062c4	g.chr9:136899859C>T	ENST00000303407.7	-	11	2214	c.2029G>A	c.(2029-2031)Ggg>Agg	p.G677R	BRD3_ENST00000473349.1_5'UTR	NM_007371.3	NP_031397.1	Q15059	BRD3_HUMAN	bromodomain containing 3	677	Ser-rich.					nucleus	protein binding	p.G677R(2)	BRD3/C15orf55(3)	kidney(1)|skin(1)|stomach(4)	6				OV - Ovarian serous cystadenocarcinoma(145;1.43e-08)|Epithelial(140;8.41e-08)|all cancers(34;5.21e-07)		CTCAGCTGCCCGCTGACATCC	0.617000			T	C15orf55	lethal midline carcinoma of young people								4	232					0	0	1	0	0
ADAM21P1	0	broad.mit.edu	37	14	70714217	70714217	+	RNA	SNP	C	C	A			TCGA-DU-A7TB-01A-11D-A33T-08	TCGA-DU-A7TB-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7095551c-6180-4cf2-a64a-a51c721f3cd7	97caf281-250f-404a-b54f-adf3225062c4	g.chr14:70714217C>A	ENST00000530196.1	-	0	301					NR_003951.1																						AGCCTTTGCACTTCTGCCCCT	0.502000													41	100					4.17593e-13	4.84408e-13	1	1	0
ANK3	288	broad.mit.edu	37	10	61958141	61958141	+	Missense_Mutation	SNP	G	G	A			TCGA-DU-A7TB-01A-11D-A33T-08	TCGA-DU-A7TB-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7095551c-6180-4cf2-a64a-a51c721f3cd7	97caf281-250f-404a-b54f-adf3225062c4	g.chr10:61958141G>A	ENST00000280772.1	-	14	1837	c.1646C>T	c.(1645-1647)gCg>gTg	p.A549V	ANK3_ENST00000373827.2_Missense_Mutation_p.A543V|ANK3_ENST00000503366.1_Missense_Mutation_p.A532V	NM_020987.3	NP_066267.2	Q12955	ANK3_HUMAN	ankyrin 3, node of Ranvier (ankyrin G)	549					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						CAAAAGGAACGCGGCCACATC	0.502000													19	127					0	0	1	0	0
TMEM203	94107	broad.mit.edu	37	9	140099751	140099751	+	Missense_Mutation	SNP	C	C	G			TCGA-DU-A7TB-01A-11D-A33T-08	TCGA-DU-A7TB-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7095551c-6180-4cf2-a64a-a51c721f3cd7	97caf281-250f-404a-b54f-adf3225062c4	g.chr9:140099751C>G	ENST00000343666.5	-	1	339	c.116G>C	c.(115-117)gGc>gCc	p.G39A	TMEM203_ENST00000537254.1_Missense_Mutation_p.G39A	NM_053045.1	NP_444273.1	Q969S6	TM203_HUMAN	transmembrane protein 203	39						integral to membrane				central_nervous_system(1)|kidney(1)	2	all_cancers(76;0.0926)		STAD - Stomach adenocarcinoma(284;0.0698)	OV - Ovarian serous cystadenocarcinoma(145;6.37e-05)|Epithelial(140;0.00057)		CGGGACCAGGCCATCCACACG	0.632000													9	19					0	0	1	0	0
USP19	10869	broad.mit.edu	37	3	49152282	49152282	+	Missense_Mutation	SNP	G	G	A			TCGA-DU-A7TB-01A-11D-A33T-08	TCGA-DU-A7TB-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7095551c-6180-4cf2-a64a-a51c721f3cd7	97caf281-250f-404a-b54f-adf3225062c4	g.chr3:49152282G>A	ENST00000453664.1	-	15	2488	c.2170C>T	c.(2170-2172)Cgg>Tgg	p.R724W	USP19_ENST00000417901.1_Missense_Mutation_p.R736W|USP19_ENST00000398888.2_Missense_Mutation_p.R633W|USP19_ENST00000398892.3_Missense_Mutation_p.R673W|USP19_ENST00000398896.1_Missense_Mutation_p.R441W|USP19_ENST00000398898.2_Missense_Mutation_p.R673W|USP19_ENST00000434032.2_Missense_Mutation_p.R734W	NM_001199161.1|NM_001199162.1	NP_001186090.1|NP_001186091.1	O94966	UBP19_HUMAN	ubiquitin specific peptidase 19	633					ER-associated protein catabolic process|positive regulation of cell cycle process|protein deubiquitination|regulation of protein stability|response to endoplasmic reticulum stress|skeletal muscle atrophy	endoplasmic reticulum membrane|integral to membrane	ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			NS(1)|breast(3)|endometrium(5)|kidney(2)|large_intestine(10)|lung(5)|ovary(4)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	38				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00219)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		ATCTTGTGCCGCTGCCATGCT	0.562000													4	100					0	0	1	0	0
BLK	640	broad.mit.edu	37	8	11418859	11418859	+	Missense_Mutation	SNP	G	G	A			TCGA-DU-A7TB-01A-11D-A33T-08	TCGA-DU-A7TB-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7095551c-6180-4cf2-a64a-a51c721f3cd7	97caf281-250f-404a-b54f-adf3225062c4	g.chr8:11418859G>A	ENST00000259089.4	+	11	1670	c.1078G>A	c.(1078-1080)Gac>Aac	p.D360N	BLK_ENST00000529894.1_Missense_Mutation_p.D289N	NM_001715.2	NP_001706.2	P51451	BLK_HUMAN	B lymphoid tyrosine kinase	360	Protein kinase.				intracellular protein kinase cascade|positive regulation of insulin secretion		ATP binding|non-membrane spanning protein tyrosine kinase activity			endometrium(1)|kidney(1)|large_intestine(5)|lung(14)|ovary(1)|skin(4)|stomach(1)	27			STAD - Stomach adenocarcinoma(15;0.00391)	COAD - Colon adenocarcinoma(149;0.207)		CATCCACCGCGACCTGCGGGC	0.557000													16	33					0	0	1	0	0
SLC38A8	146167	broad.mit.edu	37	16	84050239	84050239	+	Silent	SNP	C	C	T			TCGA-DU-A7TB-01A-11D-A33T-08	TCGA-DU-A7TB-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7095551c-6180-4cf2-a64a-a51c721f3cd7	97caf281-250f-404a-b54f-adf3225062c4	g.chr16:84050239C>T	ENST00000299709.3	-	8	1046	c.1047G>A	c.(1045-1047)ccG>ccA	p.P349P		NM_001080442.1	NP_001073911.1	A6NNN8	S38A8_HUMAN	solute carrier family 38, member 8	349					amino acid transport|sodium ion transport	integral to membrane				central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(3)|lung(12)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	26						GGATGGTCAGCGGCATCCGGA	0.637000													31	59					0	0	1	0	0
BACE2	25825	broad.mit.edu	37	21	42613772	42613772	+	Silent	SNP	C	C	T			TCGA-DU-A7TB-01A-11D-A33T-08	TCGA-DU-A7TB-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7095551c-6180-4cf2-a64a-a51c721f3cd7	97caf281-250f-404a-b54f-adf3225062c4	g.chr21:42613772C>T	ENST00000330333.6	+	4	1108	c.645C>T	c.(643-645)ttC>ttT	p.F215F	BACE2_ENST00000328735.6_Silent_p.F215F|BACE2_ENST00000466122.1_3'UTR|BACE2_ENST00000347667.4_Silent_p.F215F	NM_012105.3	NP_036237.2	Q9Y5Z0	BACE2_HUMAN	beta-site APP-cleaving enzyme 2	215					membrane protein ectodomain proteolysis|negative regulation of amyloid precursor protein biosynthetic process|peptide hormone processing	cell surface|endoplasmic reticulum|endosome|Golgi apparatus|integral to membrane	aspartic-type endopeptidase activity			endometrium(2)|large_intestine(3)|lung(4)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	14		Prostate(19;1.57e-07)|all_epithelial(19;0.0251)				AGACCTTCTTCGACTCCCTGG	0.582000													69	139					0	0	1	0	0
RSPO3	84870	broad.mit.edu	37	6	127471594	127471594	+	Missense_Mutation	SNP	T	T	A			TCGA-DU-A7TB-01A-11D-A33T-08	TCGA-DU-A7TB-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7095551c-6180-4cf2-a64a-a51c721f3cd7	97caf281-250f-404a-b54f-adf3225062c4	g.chr6:127471594T>A	ENST00000356698.4	+	3	902	c.313T>A	c.(313-315)Tgt>Agt	p.C105S	RSPO3_ENST00000485757.1_3'UTR|RSPO3_ENST00000368317.3_Missense_Mutation_p.C105S	NM_032784.3	NP_116173.2	Q9BXY4	RSPO3_HUMAN	R-spondin 3	105						extracellular region	heparin binding		PTPRK/RSPO3(10)	breast(1)|cervix(1)|endometrium(3)|large_intestine(3)|lung(8)|skin(1)	17				GBM - Glioblastoma multiforme(226;0.0555)		CTGTGATACCTGTTTCAACAA	0.373000													40	86					0	0	1	0	0
SH3BP5	9467	broad.mit.edu	37	3	15300421	15300421	+	Missense_Mutation	SNP	C	C	T			TCGA-DU-A7TB-01A-11D-A33T-08	TCGA-DU-A7TB-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7095551c-6180-4cf2-a64a-a51c721f3cd7	97caf281-250f-404a-b54f-adf3225062c4	g.chr3:15300421C>T	ENST00000383791.3	-	7	1026	c.806G>A	c.(805-807)cGg>cAg	p.R269Q	SH3BP5_ENST00000253688.5_Missense_Mutation_p.R112Q|SH3BP5_ENST00000426925.1_Missense_Mutation_p.R112Q|SH3BP5-AS1_ENST00000420195.1_RNA|SH3BP5-AS1_ENST00000413977.1_RNA|SH3BP5_ENST00000408919.3_Missense_Mutation_p.R112Q|SH3BP5-AS1_ENST00000436602.1_RNA	NM_004844.4	NP_004835.2	O60239	3BP5_HUMAN	SH3-domain binding protein 5 (BTK-associated)	269					intracellular signal transduction	mitochondrion	protein kinase inhibitor activity|SH3 domain binding			NS(1)|endometrium(3)|large_intestine(3)|lung(3)|ovary(1)|prostate(1)	12						ACCGCATCCCCGAGGCCCCAT	0.597000													37	58					0	0	1	0	0
RP11-156P1.3	0	broad.mit.edu	37	17	45128792	45128792	+	RNA	SNP	G	G	T	rs143713325	by1000genomes	TCGA-DU-A7TB-01A-11D-A33T-08	TCGA-DU-A7TB-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7095551c-6180-4cf2-a64a-a51c721f3cd7	97caf281-250f-404a-b54f-adf3225062c4	g.chr17:45128792G>T	ENST00000575173.1	-	0	418																											AATTCAGGTTGTCAGAATGCA	0.373000													7	111					8.12818e-05	8.57154e-05	1	1	0
DNM1P47	0	broad.mit.edu	37	15	102304869	102304869	+	RNA	SNP	T	T	C	rs139457262	by1000genomes	TCGA-DU-A7TB-01A-11D-A33T-08	TCGA-DU-A7TB-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7095551c-6180-4cf2-a64a-a51c721f3cd7	97caf281-250f-404a-b54f-adf3225062c4	g.chr15:102304869T>C	ENST00000561463.1	+	0	12915																											GTCCAACCTGTACTCGCGTGG	0.572000													4	36					0	0	1	0	0
ZMYM6	9204	broad.mit.edu	37	1	35476613	35476613	+	Missense_Mutation	SNP	T	T	C			TCGA-DU-A7TB-01A-11D-A33T-08	TCGA-DU-A7TB-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7095551c-6180-4cf2-a64a-a51c721f3cd7	97caf281-250f-404a-b54f-adf3225062c4	g.chr1:35476613T>C	ENST00000357182.4	-	9	1314	c.1087A>G	c.(1087-1089)Aca>Gca	p.T363A	ZMYM6_ENST00000487874.1_Missense_Mutation_p.T363A|ZMYM6_ENST00000373340.2_Missense_Mutation_p.T363A|ZMYM6_ENST00000493328.1_5'UTR	NM_007167.3	NP_009098.3	O95789	ZMYM6_HUMAN	zinc finger, MYM-type 6	363					multicellular organismal development	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(12)|lung(10)|ovary(4)|pancreas(1)|prostate(1)|skin(1)	44		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.13)				GAAGAGTTTGTTCCTTTTGGC	0.433000													33	54					0	0	1	0	0
ROS1	6098	broad.mit.edu	37	6	117700221	117700221	+	Splice_Site	SNP	C	C	A			TCGA-DU-A7TB-01A-11D-A33T-08	TCGA-DU-A7TB-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7095551c-6180-4cf2-a64a-a51c721f3cd7	97caf281-250f-404a-b54f-adf3225062c4	g.chr6:117700221C>A	ENST00000368508.3	-	17	2796		c.e17+1		ROS1_ENST00000368507.3_Splice_Site|GOPC_ENST00000467125.1_Intron	NM_002944.2	NP_002935.2	P08922	ROS_HUMAN	c-ros oncogene 1 , receptor tyrosine kinase						transmembrane receptor protein tyrosine kinase signaling pathway	membrane fraction|sodium:potassium-exchanging ATPase complex	ATP binding|transmembrane receptor protein tyrosine kinase activity		TPM3_ENST00000368530/ROS1(4)|LRIG3/ROS1(2)|CD74_ENST00000009530/ROS1(32)|SLC34A2/ROS1(14)|EZR/ROS1(4)|GOPC/ROS1(14)|SDC4/ROS1(7)	NS(2)|breast(7)|central_nervous_system(5)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(28)|lung(56)|ovary(8)|prostate(5)|skin(19)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(3)	162		all_cancers(87;0.00846)|all_epithelial(87;0.0242)		GBM - Glioblastoma multiforme(226;0.0387)|OV - Ovarian serous cystadenocarcinoma(136;0.0954)|all cancers(137;0.137)		ACTCTACTTACCTCTGTCCCC	0.383000			T	"""GOPC, SDC4, SLC34A2, EZR, LRIG3"""	"""glioblastoma, NSCLC"""								7	91					2.7689e-08	3.08838e-08	1	1	0
FLT3	2322	broad.mit.edu	37	13	28608473	28608473	+	Missense_Mutation	SNP	C	C	T	rs35958982	byFrequency	TCGA-DU-A7TB-01A-11D-A33T-08	TCGA-DU-A7TB-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7095551c-6180-4cf2-a64a-a51c721f3cd7	97caf281-250f-404a-b54f-adf3225062c4	g.chr13:28608473C>T	ENST00000380982.4	-	13	1750	c.1669G>A	c.(1669-1671)Gtt>Att	p.V557I	FLT3_ENST00000537084.1_Missense_Mutation_p.V557I|FLT3_ENST00000241453.7_Missense_Mutation_p.V557I			P36888	FLT3_HUMAN	fms-related tyrosine kinase 3	557			V -> I (in dbSNP:rs35958982).		positive regulation of cell proliferation	integral to plasma membrane	ATP binding|vascular endothelial growth factor receptor activity	p.V557I(1)		NS(1)|breast(3)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(12329)|kidney(2)|large_intestine(8)|lung(30)|ovary(4)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	12390	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0156)|Ovarian(182;0.0392)	Colorectal(13;0.000157)|READ - Rectum adenocarcinoma(15;0.105)	OV - Ovarian serous cystadenocarcinoma(117;0.00154)|all cancers(112;0.00459)|GBM - Glioblastoma multiforme(144;0.00562)|Epithelial(112;0.0959)|Lung(94;0.212)	Sorafenib(DB00398)|Sunitinib(DB01268)	AGGGTTAAAACGACAATGAAG	0.393000			"""Mis, O"""		"""AML, ALL"""								37	89					0	0	1	0	0
VSIG2	23584	broad.mit.edu	37	11	124619648	124619648	+	Missense_Mutation	SNP	C	C	T	rs148389397		TCGA-DU-A7TB-01A-11D-A33T-08	TCGA-DU-A7TB-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7095551c-6180-4cf2-a64a-a51c721f3cd7	97caf281-250f-404a-b54f-adf3225062c4	g.chr11:124619648C>T	ENST00000403470.1	-	4	597	c.542G>A	c.(541-543)cGt>cAt	p.R181H	VSIG2_ENST00000326621.5_Missense_Mutation_p.R181H			Q96IQ7	VSIG2_HUMAN	V-set and immunoglobulin domain containing 2	181	Ig-like C2-type.					integral to plasma membrane|membrane fraction				central_nervous_system(1)|cervix(1)|kidney(2)|large_intestine(2)|lung(8)|ovary(5)	19	all_hematologic(175;0.215)	Breast(109;0.00663)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0215)		AGTTCCAAGACGCACCCAGTT	0.557000													56	84					0	0	1	0	0
EVC2	132884	broad.mit.edu	37	4	5696191	5696191	+	Missense_Mutation	SNP	C	C	T			TCGA-DU-A7TB-01A-11D-A33T-08	TCGA-DU-A7TB-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7095551c-6180-4cf2-a64a-a51c721f3cd7	97caf281-250f-404a-b54f-adf3225062c4	g.chr4:5696191C>T	ENST00000310917.2	-	3	812	c.81G>A	c.(79-81)atG>atA	p.M27I	EVC2_ENST00000344408.5_Missense_Mutation_p.M107I|EVC2_ENST00000344938.1_Missense_Mutation_p.M107I	NM_001166136.1	NP_001159608.1	Q86UK5	LBN_HUMAN	Ellis van Creveld syndrome 2	107						integral to membrane				NS(2)|breast(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(32)|lung(28)|ovary(4)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|urinary_tract(2)	81						TGAAGACTTCCATTTTCTTGT	0.413000													35	93					0	0	1	0	0
ADAM21	8747	broad.mit.edu	37	14	70924377	70924377	+	Missense_Mutation	SNP	G	G	T			TCGA-DU-A7TB-01A-11D-A33T-08	TCGA-DU-A7TB-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7095551c-6180-4cf2-a64a-a51c721f3cd7	97caf281-250f-404a-b54f-adf3225062c4	g.chr14:70924377G>T	ENST00000603540.1	+	2	419	c.161G>T	c.(160-162)aGt>aTt	p.S54I	ADAM21_ENST00000267499.3_Missense_Mutation_p.S54I|RP11-486O13.4_ENST00000556646.1_lincRNA	NM_003813.3	NP_003804.2	Q9UKJ8	ADA21_HUMAN	ADAM metallopeptidase domain 21	54					proteolysis|single fertilization	integral to membrane	metalloendopeptidase activity|zinc ion binding			central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(10)|lung(10)|pancreas(1)|prostate(1)|skin(2)|stomach(1)	31				all cancers(60;0.00326)|BRCA - Breast invasive adenocarcinoma(234;0.00646)|OV - Ovarian serous cystadenocarcinoma(108;0.0401)		AGGGGCAGAAGTGCAAAGGCT	0.522000													18	250					7.33532e-06	7.87868e-06	1	1	0
DISP2	85455	broad.mit.edu	37	15	40661876	40661876	+	Missense_Mutation	SNP	G	G	A			TCGA-DU-A7TB-01A-11D-A33T-08	TCGA-DU-A7TB-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7095551c-6180-4cf2-a64a-a51c721f3cd7	97caf281-250f-404a-b54f-adf3225062c4	g.chr15:40661876G>A	ENST00000267889.3	+	8	3650	c.3563G>A	c.(3562-3564)cGg>cAg	p.R1188Q		NM_033510.1	NP_277045.1	A7MBM2	DISP2_HUMAN	dispatched homolog 2 (Drosophila)	1188					smoothened signaling pathway	integral to membrane				breast(1)|endometrium(4)|kidney(2)|large_intestine(7)|lung(12)|ovary(4)	30		all_cancers(109;9.35e-19)|all_epithelial(112;1.18e-15)|Lung NSC(122;2.45e-11)|all_lung(180;6.47e-10)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;3.39e-06)|Colorectal(105;0.0114)|READ - Rectum adenocarcinoma(2;0.0649)|BRCA - Breast invasive adenocarcinoma(123;0.0798)|Lung(196;0.15)|LUAD - Lung adenocarcinoma(183;0.247)		CTGTCCCACCGGCCCTCAGTA	0.652000													61	137					0	0	1	0	0
NAF1	92345	broad.mit.edu	37	4	164050411	164050411	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DU-A7TB-01A-11D-A33T-08	TCGA-DU-A7TB-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7095551c-6180-4cf2-a64a-a51c721f3cd7	97caf281-250f-404a-b54f-adf3225062c4	g.chr4:164050411G>A	ENST00000274054.2	-	8	1316	c.1123C>T	c.(1123-1125)Cga>Tga	p.R375*	NAF1_ENST00000509434.1_Intron|NAF1_ENST00000422287.2_Intron	NM_138386.2	NP_612395.2	Q96HR8	NAF1_HUMAN	nuclear assembly factor 1 ribonucleoprotein	375					rRNA processing|snRNA pseudouridine synthesis	cytoplasm|nucleus|small nucleolar ribonucleoprotein complex	protein binding|snoRNA binding			NS(1)|autonomic_ganglia(1)|endometrium(3)|kidney(3)|large_intestine(1)|lung(10)|ovary(2)	21	all_hematologic(180;0.166)	Prostate(90;0.109)				GAAAATCCTCGTGTGAATTCT	0.448000													19	83					0	0	1	0	0
TNXB	7148	broad.mit.edu	37	6	32020677	32020677	+	Missense_Mutation	SNP	C	C	T			TCGA-DU-A7TB-01A-11D-A33T-08	TCGA-DU-A7TB-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7095551c-6180-4cf2-a64a-a51c721f3cd7	97caf281-250f-404a-b54f-adf3225062c4	g.chr6:32020677C>T	ENST00000375244.3	-	26	9086	c.8885G>A	c.(8884-8886)gGa>gAa	p.G2962E	TNXB_ENST00000375247.2_Missense_Mutation_p.G2960E			P22105	TENX_HUMAN	tenascin XB	3007	Fibronectin type-III 21.				actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|prostate(1)	8						AGGGGAGGATCCTGTCACTGT	0.667000													6	110					0	0	1	0	0
FRY	10129	broad.mit.edu	37	13	32605977	32605977	+	Silent	SNP	A	A	G			TCGA-DU-A7TB-01A-11D-A33T-08	TCGA-DU-A7TB-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7095551c-6180-4cf2-a64a-a51c721f3cd7	97caf281-250f-404a-b54f-adf3225062c4	g.chr13:32605977A>G	ENST00000380250.3	+	1	541	c.45A>G	c.(43-45)aaA>aaG	p.K15K	FRY_ENST00000463566.1_3'UTR	NM_023037.2	NP_075463.2	Q5TBA9	FRY_HUMAN	furry homolog (Drosophila)	15					regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to membrane				NS(3)|breast(4)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(31)|lung(50)|ovary(5)|pancreas(1)|prostate(6)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	132		Lung SC(185;0.0271)		all cancers(112;4.81e-05)|Epithelial(112;0.000656)|OV - Ovarian serous cystadenocarcinoma(117;0.0123)|BRCA - Breast invasive adenocarcinoma(63;0.0295)|GBM - Glioblastoma multiforme(144;0.104)		TCAGTATCAAATATTTACTGA	0.468000													23	33					0	0	1	0	0
AIFM3	150209	broad.mit.edu	37	22	21330015	21330015	+	Missense_Mutation	SNP	G	G	A			TCGA-DU-A7TB-01A-11D-A33T-08	TCGA-DU-A7TB-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7095551c-6180-4cf2-a64a-a51c721f3cd7	97caf281-250f-404a-b54f-adf3225062c4	g.chr22:21330015G>A	ENST00000399167.2	+	9	995	c.755G>A	c.(754-756)aGg>aAg	p.R252K	AIFM3_ENST00000333607.6_Missense_Mutation_p.R252K|AIFM3_ENST00000335375.5_Missense_Mutation_p.R240K|AIFM3_ENST00000405089.1_Missense_Mutation_p.R258K|AIFM3_ENST00000399163.2_Missense_Mutation_p.R252K|AIFM3_ENST00000465606.1_3'UTR|AIFM3_ENST00000440238.2_Missense_Mutation_p.R252K	NM_144704.2	NP_653305.1			apoptosis-inducing factor, mitochondrion-associated, 3											breast(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(3)|lung(5)|ovary(3)|prostate(1)|skin(2)|urinary_tract(1)	21	all_cancers(11;3.71e-26)|all_epithelial(7;1.59e-23)|Lung NSC(8;3.06e-15)|all_lung(8;5.05e-14)|Melanoma(16;0.000465)|Ovarian(15;0.0028)|Colorectal(54;0.0332)|all_neural(72;0.142)	Lung SC(17;0.0367)	LUSC - Lung squamous cell carcinoma(15;0.000204)|Lung(15;0.00494)|Epithelial(17;0.195)			CTGGCCCTGAGGCCCAAGGAG	0.617000													53	131					0	0	1	0	0
CNOT3	4849	broad.mit.edu	37	19	54646885	54646885	+	Missense_Mutation	SNP	C	C	T			TCGA-DU-A7TB-01A-11D-A33T-08	TCGA-DU-A7TB-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7095551c-6180-4cf2-a64a-a51c721f3cd7	97caf281-250f-404a-b54f-adf3225062c4	g.chr19:54646885C>T	ENST00000406403.1	+	2	1659	c.56C>T	c.(55-57)tCc>tTc	p.S19F	CNOT3_ENST00000358389.3_5'UTR|CNOT3_ENST00000221232.5_Missense_Mutation_p.S19F			O75175	CNOT3_HUMAN	CCR4-NOT transcription complex, subunit 3	19					nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol|nucleus	protein binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(3)|lung(6)|ovary(3)|prostate(7)|urinary_tract(3)	28	all_cancers(19;0.0065)|all_epithelial(19;0.00348)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)					AAGAAGGTGTCCGAGGGCGTG	0.547000													78	89					0	0	1	0	0
FBN1	2200	broad.mit.edu	37	15	48764802	48764802	+	Missense_Mutation	SNP	G	G	A			TCGA-DU-A7TB-01A-11D-A33T-08	TCGA-DU-A7TB-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7095551c-6180-4cf2-a64a-a51c721f3cd7	97caf281-250f-404a-b54f-adf3225062c4	g.chr15:48764802G>A	ENST00000316623.5	-	35	4737	c.4282C>T	c.(4282-4284)Cgc>Tgc	p.R1428C		NM_000138.4	NP_000129.3	P35555	FBN1_HUMAN	fibrillin 1	1428	EGF-like 24; calcium-binding.				heart development|negative regulation of BMP signaling pathway by extracellular sequestering of BMP|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|skeletal system development	basement membrane|extracellular space|microfibril	calcium ion binding|extracellular matrix structural constituent|protein binding			NS(1)|breast(5)|cervix(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(43)|liver(1)|lung(49)|ovary(4)|pancreas(1)|prostate(9)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	139		all_lung(180;0.00279)		all cancers(107;4.24e-07)|GBM - Glioblastoma multiforme(94;1.41e-05)		CATTCACAGCGGTATCCTCCT	0.542000													6	175					0	0	1	0	0
TNFRSF25	8718	broad.mit.edu	37	1	6521665	6521665	+	Missense_Mutation	SNP	G	G	C			TCGA-DU-A7TB-01A-11D-A33T-08	TCGA-DU-A7TB-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7095551c-6180-4cf2-a64a-a51c721f3cd7	97caf281-250f-404a-b54f-adf3225062c4	g.chr1:6521665G>C	ENST00000377782.3	-	10	1177	c.1110C>G	c.(1108-1110)atC>atG	p.I370M	TNFRSF25_ENST00000356876.3_Missense_Mutation_p.I361M|TNFRSF25_ENST00000348333.3_Missense_Mutation_p.I316M|TNFRSF25_ENST00000351959.5_Missense_Mutation_p.I324M|TNFRSF25_ENST00000351748.3_Missense_Mutation_p.I178M	NM_148965.1	NP_683866.1	Q93038	TNR25_HUMAN	tumor necrosis factor receptor superfamily, member 25	361	Death.		R -> L (in dbSNP:rs1064590).		apoptosis|induction of apoptosis by extracellular signals	cytosol|extracellular region|integral to plasma membrane	tumor necrosis factor receptor activity			breast(1)|central_nervous_system(2)|endometrium(1)|lung(4)|prostate(1)|stomach(1)	10	Ovarian(185;0.0386)|all_lung(157;0.154)	all_cancers(23;1.7e-35)|all_epithelial(116;2.78e-22)|all_lung(118;7.57e-07)|Lung NSC(185;4.26e-06)|Colorectal(325;4.47e-05)|all_hematologic(16;0.00014)|Breast(487;0.000688)|Renal(390;0.0007)|Acute lymphoblastic leukemia(12;0.00157)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0448)		Epithelial(90;4.58e-35)|GBM - Glioblastoma multiforme(13;3.06e-27)|Colorectal(212;6.01e-08)|COAD - Colon adenocarcinoma(227;1.3e-05)|Kidney(185;4.88e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000871)|BRCA - Breast invasive adenocarcinoma(365;0.00105)|STAD - Stomach adenocarcinoma(132;0.00158)|READ - Rectum adenocarcinoma(331;0.0419)		CCACGGCTTCGATCTCTGCCT	0.697000													24	23					0	0	1	0	0
ZCCHC11	23318	broad.mit.edu	37	1	52902559	52902559	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DU-A7TB-01A-11D-A33T-08	TCGA-DU-A7TB-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7095551c-6180-4cf2-a64a-a51c721f3cd7	97caf281-250f-404a-b54f-adf3225062c4	g.chr1:52902559G>A	ENST00000371544.3	-	26	4289	c.4027C>T	c.(4027-4029)Cga>Tga	p.R1343*	ZCCHC11_ENST00000257177.4_Nonsense_Mutation_p.R1344*	NM_001009881.2|NM_015269.2	NP_001009881.1|NP_056084.1	Q5TAX3	TUT4_HUMAN	zinc finger, CCHC domain containing 11	1343					miRNA catabolic process|pre-miRNA processing|RNA 3'-end processing|stem cell maintenance	cytoplasm|nucleolus	nucleic acid binding|protein binding|RNA uridylyltransferase activity|zinc ion binding			NS(2)|breast(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(15)|lung(17)|ovary(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	58						TGGAGGTCTCGGGGGTCAAGA	0.458000													74	118					0	0	1	0	0
MROH2B	133558	broad.mit.edu	37	5	41058182	41058182	+	Missense_Mutation	SNP	C	C	A			TCGA-DU-A7TB-01A-11D-A33T-08	TCGA-DU-A7TB-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7095551c-6180-4cf2-a64a-a51c721f3cd7	97caf281-250f-404a-b54f-adf3225062c4	g.chr5:41058182C>A	ENST00000399564.4	-	7	1189	c.739G>T	c.(739-741)Gat>Tat	p.D247Y	MROH2B_ENST00000506092.2_5'UTR	NM_173489.4	NP_775760.3			maestro heat-like repeat family member 2B																		ACATGGAAATCAATCTCTTTG	0.532000													13	56					0.00185496	0.00185496	1	1	0
RHAG	6005	broad.mit.edu	37	6	49585873	49585873	+	Missense_Mutation	SNP	C	C	T			TCGA-DU-A7TB-01A-11D-A33T-08	TCGA-DU-A7TB-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7095551c-6180-4cf2-a64a-a51c721f3cd7	97caf281-250f-404a-b54f-adf3225062c4	g.chr6:49585873C>T	ENST00000371175.4	-	3	426	c.400G>A	c.(400-402)Gga>Aga	p.G134R	RHAG_ENST00000229810.7_Missense_Mutation_p.G134R	NM_000324.2	NP_000315.2	Q02094	RHAG_HUMAN	Rh-associated glycoprotein	134					carbon dioxide transport|cellular ion homeostasis	integral to plasma membrane	ammonia transmembrane transporter activity|ammonium transmembrane transporter activity|ankyrin binding			NS(1)|breast(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(24)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	39	Lung NSC(77;0.0255)					CTCGTTTTTCCCAGGACAGCT	0.393000													26	47					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179445326	179445326	+	Silent	SNP	C	C	T			TCGA-DU-A7TB-01A-11D-A33T-08	TCGA-DU-A7TB-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7095551c-6180-4cf2-a64a-a51c721f3cd7	97caf281-250f-404a-b54f-adf3225062c4	g.chr2:179445326C>T	ENST00000589042.1	-	317	67004	c.66780G>A	c.(66778-66780)gaG>gaA	p.E22260E	TTN-AS1_ENST00000419746.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN_ENST00000359218.5_Silent_p.E13320E|TTN_ENST00000591111.1_Silent_p.E20619E|TTN-AS1_ENST00000590932.1_RNA|TTN_ENST00000342992.6_Silent_p.E19692E|TTN-AS1_ENST00000586831.1_RNA|TTN-AS1_ENST00000438095.1_RNA|TTN_ENST00000342175.6_Silent_p.E13387E|TTN-AS1_ENST00000586707.1_RNA|RP11-171I2.2_ENST00000603521.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Silent_p.E13195E|TTN-AS1_ENST00000456053.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000592600.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	20619	Fibronectin type-III 61.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CAAGTTCTCCCTCAGGTGGAA	0.378000													16	47					0	0	1	0	0
PLEKHA8	84725	broad.mit.edu	37	7	30113727	30113727	+	Missense_Mutation	SNP	G	G	C			TCGA-DU-A7TB-01A-11D-A33T-08	TCGA-DU-A7TB-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7095551c-6180-4cf2-a64a-a51c721f3cd7	97caf281-250f-404a-b54f-adf3225062c4	g.chr7:30113727G>C	ENST00000449726.1	+	13	1691	c.1341G>C	c.(1339-1341)tgG>tgC	p.W447C	PLEKHA8_ENST00000396259.1_Intron|PLEKHA8_ENST00000396257.2_Missense_Mutation_p.W447C|PLEKHA8_ENST00000258679.7_Intron|AC007285.7_ENST00000433088.1_RNA	NM_001197027.1	NP_001183956.1	Q96JA3	PKHA8_HUMAN	pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 8	447					protein transport	cytoplasm	glycolipid binding|glycolipid transporter activity			breast(4)|large_intestine(3)|lung(8)|ovary(1)|prostate(1)	17						ACCATGGCTGGGTAGTTCGAG	0.408000													28	65					0	0	1	0	0
SCO2	9997	broad.mit.edu	37	22	50962164	50962164	+	Missense_Mutation	SNP	A	A	G	rs150742660		TCGA-DU-A7TB-01A-11D-A33T-08	TCGA-DU-A7TB-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7095551c-6180-4cf2-a64a-a51c721f3cd7	97caf281-250f-404a-b54f-adf3225062c4	g.chr22:50962164A>G	ENST00000543927.1	-	2	883	c.677T>C	c.(676-678)aTt>aCt	p.I226T	SCO2_ENST00000252785.3_Missense_Mutation_p.I226T|SCO2_ENST00000395693.3_Missense_Mutation_p.I226T|SCO2_ENST00000535425.1_Missense_Mutation_p.I226T	NM_001169109.1	NP_001162580.1	O43819	SCO2_HUMAN	SCO2 cytochrome c oxidase assembly protein	226	Thioredoxin.				cell redox homeostasis|cellular copper ion homeostasis|copper ion transport|oxidation-reduction process|respiratory chain complex IV assembly	mitochondrial inner membrane	copper ion binding			endometrium(1)|lung(1)	2		all_cancers(38;4.58e-14)|all_epithelial(38;1.12e-12)|all_lung(38;3.07e-05)|Breast(42;6.27e-05)|Lung NSC(38;0.000813)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		GTAGATGGCAATGGAGTGGTC	0.587000													66	130					0	0	1	0	0
SYNM	23336	broad.mit.edu	37	15	99669671	99669671	+	Missense_Mutation	SNP	A	A	G			TCGA-DU-A7TB-01A-11D-A33T-08	TCGA-DU-A7TB-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7095551c-6180-4cf2-a64a-a51c721f3cd7	97caf281-250f-404a-b54f-adf3225062c4	g.chr15:99669671A>G	ENST00000336292.6	+	5	1223	c.1103A>G	c.(1102-1104)aAt>aGt	p.N368S	RP11-6O2.4_ENST00000566974.1_RNA|SYNM_ENST00000561323.1_3'UTR|SYNM_ENST00000328642.7_Missense_Mutation_p.N368S|SYNM_ENST00000560674.1_Missense_Mutation_p.N83S	NM_145728.2	NP_663780.2	O15061	SYNEM_HUMAN	synemin, intermediate filament protein	369	Tail.				intermediate filament cytoskeleton organization	adherens junction|costamere|intermediate filament|neurofilament cytoskeleton	intermediate filament binding|structural constituent of cytoskeleton|structural constituent of muscle|vinculin binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(3)|kidney(1)|large_intestine(8)|lung(6)|ovary(3)|prostate(1)|skin(2)|urinary_tract(1)	29						GCAAGTTTCAATCACAGCTCG	0.468000													8	288					0	0	1	0	0
SLC22A6	9356	broad.mit.edu	37	11	62744732	62744732	+	Missense_Mutation	SNP	C	C	A			TCGA-DU-A7TB-01A-11D-A33T-08	TCGA-DU-A7TB-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7095551c-6180-4cf2-a64a-a51c721f3cd7	97caf281-250f-404a-b54f-adf3225062c4	g.chr11:62744732C>A	ENST00000377871.3	-	9	1755	c.1489G>T	c.(1489-1491)Gcc>Tcc	p.A497S	SLC22A6_ENST00000458333.2_Intron|SLC22A6_ENST00000421062.2_Intron|SLC22A6_ENST00000360421.4_Missense_Mutation_p.A497S	NM_004790.4|NM_153278.2	NP_004781.2|NP_695010.1	Q4U2R8	S22A6_HUMAN	solute carrier family 22 (organic anion transporter), member 6	497					alpha-ketoglutarate transport	basolateral plasma membrane|integral to plasma membrane|membrane fraction	inorganic anion exchanger activity|protein binding	p.A497T(1)		breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|lung(18)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	36						ACAGCGCTGGCGGCCACAGGA	0.642000													21	107					2.70639e-06	2.96171e-06	1	1	0
WBP11P1	0	broad.mit.edu	37	18	30091975	30091975	+	RNA	SNP	C	C	T			TCGA-DU-A7TB-01A-11D-A33T-08	TCGA-DU-A7TB-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7095551c-6180-4cf2-a64a-a51c721f3cd7	97caf281-250f-404a-b54f-adf3225062c4	g.chr18:30091975C>T	ENST00000567636.1	+	0	350					NR_003558.1																						ACAGATGATCCGAGACATGGA	0.413000													32	59					0	0	1	0	0
NT5C1A	84618	broad.mit.edu	37	1	40131320	40131320	+	Silent	SNP	A	A	T			TCGA-DU-A7TB-01A-11D-A33T-08	TCGA-DU-A7TB-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7095551c-6180-4cf2-a64a-a51c721f3cd7	97caf281-250f-404a-b54f-adf3225062c4	g.chr1:40131320A>T	ENST00000235628.1	-	3	305	c.306T>A	c.(304-306)gcT>gcA	p.A102A		NM_032526.1	NP_115915.1	Q9BXI3	5NT1A_HUMAN	5'-nucleotidase, cytosolic IA	102					purine base metabolic process|purine nucleotide catabolic process|pyrimidine base metabolic process|pyrimidine nucleoside catabolic process	cytosol	5'-nucleotidase activity|magnesium ion binding|nucleotide binding			breast(1)|large_intestine(3)|lung(7)|ovary(2)|prostate(2)	15	Lung NSC(20;3.81e-06)|Ovarian(52;0.00769)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0393)	OV - Ovarian serous cystadenocarcinoma(33;1.87e-18)|Epithelial(16;4.3e-17)|all cancers(16;8.48e-16)|LUSC - Lung squamous cell carcinoma(16;0.000261)|Lung(16;0.000457)			CGGCCTCCAGAGCCTGGAAAG	0.577000													4	86					0	0	1	0	0
PIK3R1	5295	broad.mit.edu	37	5	67591247	67591249	+	Splice_Site	DEL	GGT	GGT	-			TCGA-DU-A7TB-01A-11D-A33T-08	TCGA-DU-A7TB-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7095551c-6180-4cf2-a64a-a51c721f3cd7	97caf281-250f-404a-b54f-adf3225062c4	g.chr5:67591247_67591249delGGT	ENST00000521381.1	+	14	2361_2363	c.1745_splice	c.e14-1	p.R582_splice	PIK3R1_ENST00000274335.5_Splice_Site_p.R582_splice|PIK3R1_ENST00000320694.8_Splice_Site_p.R282_splice|PIK3R1_ENST00000523872.1_Splice_Site_p.R219_splice|PIK3R1_ENST00000336483.5_Splice_Site_p.R312_splice|PIK3R1_ENST00000396611.1_Splice_Site_p.R582_splice|PIK3R1_ENST00000521657.1_Splice_Site_p.R582_splice	NM_181523.2	NP_852664.1	P27986	P85A_HUMAN	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	582					epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|growth hormone receptor signaling pathway|insulin receptor signaling pathway|insulin-like growth factor receptor signaling pathway|interspecies interaction between organisms|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol 3-kinase cascade|phosphatidylinositol phosphorylation|phosphatidylinositol-mediated signaling|platelet activation|positive regulation of establishment of protein localization in plasma membrane|positive regulation of glucose import|T cell costimulation|T cell receptor signaling pathway	1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex	1-phosphatidylinositol binding|ErbB-3 class receptor binding|insulin binding|insulin receptor binding|insulin receptor substrate binding|insulin-like growth factor receptor binding|phosphatidylinositol 3-kinase regulator activity|protein phosphatase binding	p.M582_D605>I(4)|p.?(4)|p.Y580fs*1(1)|p.0?(1)		breast(12)|central_nervous_system(31)|cervix(1)|endometrium(68)|haematopoietic_and_lymphoid_tissue(5)|kidney(1)|large_intestine(32)|lung(10)|ovary(9)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	178		Lung NSC(167;1.99e-05)|Prostate(74;0.00308)|Ovarian(174;0.00473)|Colorectal(97;0.0176)		OV - Ovarian serous cystadenocarcinoma(47;3.76e-51)|Lung(70;0.0211)	Isoproterenol(DB01064)	CTGTTTTTCAGGTGGTTGACTCA	0.365			"""Mis, F, O"""		"""gliobastoma, ovarian, colorectal"""					TCGA GBM(4;<1E-08)			44	90	---	---	---	---					
TDP2	51567	broad.mit.edu	37	6	24651110	24651110	+	Frame_Shift_Del	DEL	C	C	-			TCGA-DU-A7TB-01A-11D-A33T-08	TCGA-DU-A7TB-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7095551c-6180-4cf2-a64a-a51c721f3cd7	97caf281-250f-404a-b54f-adf3225062c4	g.chr6:24651110delC	ENST00000341060.3	-	6	1216	c.821delG	c.(820-822)cafs	p.R274fs	TDP2_ENST00000545995.1_Frame_Shift_Del_p.R362fs|TDP2_ENST00000378198.4_Frame_Shift_Del_p.R332fs			O95551	TYDP2_HUMAN	tyrosyl-DNA phosphodiesterase 2	332					cell surface receptor linked signaling pathway|double-strand break repair	PML body	5'-tyrosyl-DNA phosphodiesterase activity|magnesium ion binding|nuclease activity|protein binding|transcription corepressor activity			kidney(2)|large_intestine(1)|lung(5)|ovary(1)	9						GTCCAAACTTCGGGGAATAAT	0.383								Direct reversal of damage					59	98	---	---	---	---					
CCDC146	57639	broad.mit.edu	37	7	76916122	76916122	+	Frame_Shift_Del	DEL	A	A	-			TCGA-DU-A7TB-01A-11D-A33T-08	TCGA-DU-A7TB-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7095551c-6180-4cf2-a64a-a51c721f3cd7	97caf281-250f-404a-b54f-adf3225062c4	g.chr7:76916122delA	ENST00000285871.4	+	16	2283	c.2156delA	c.(2155-2157)cgfs	p.Q719fs	CCDC146_ENST00000415740.2_3'UTR|CCDC146_ENST00000431197.1_Frame_Shift_Del_p.Q433fs	NM_020879.2	NP_065930.2	Q8IYE0	CC146_HUMAN	coiled-coil domain containing 146	719										breast(3)|central_nervous_system(3)|endometrium(1)|kidney(4)|large_intestine(7)|lung(10)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|stomach(2)	34		all_cancers(73;0.128)|all_lung(88;0.0986)|all_epithelial(88;0.163)|Myeloproliferative disorder(862;0.205)				TAGTTTTCACAGTGTACAGAC	0.373													59	116	---	---	---	---					
C11orf95	65998	broad.mit.edu	37	11	63533335	63533337	+	RNA	DEL	TCC	TCC	-			TCGA-DU-A7TB-01A-11D-A33T-08	TCGA-DU-A7TB-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7095551c-6180-4cf2-a64a-a51c721f3cd7	97caf281-250f-404a-b54f-adf3225062c4	g.chr11:63533335_63533337delTCC	ENST00000433688.1	-	0	597_599							C9JLR9	CK095_HUMAN	chromosome 11 open reading frame 95							intracellular	zinc ion binding										ctcctcttcttcctcctcctcct	0.670													2	4	---	---	---	---					
THRA	7067	broad.mit.edu	37	17	38245687	38245690	+	Frame_Shift_Del	DEL	TCTT	TCTT	-			TCGA-DU-A7TB-01A-11D-A33T-08	TCGA-DU-A7TB-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7095551c-6180-4cf2-a64a-a51c721f3cd7	97caf281-250f-404a-b54f-adf3225062c4	g.chr17:38245687_38245690delTCTT	ENST00000450525.2	+	9	1702_1705	c.1211_1214delTCTT	c.(1210-1215)gtfs	p.VF404fs	THRA_ENST00000394121.4_Intron|THRA_ENST00000546243.1_Frame_Shift_Del_p.VF404fs|THRA_ENST00000264637.4_Intron|THRA_ENST00000584985.1_Intron	NM_199334.3	NP_955366.1	P10827	THA_HUMAN	thyroid hormone receptor, alpha	0					negative regulation of RNA polymerase II transcriptional preinitiation complex assembly|negative regulation of transcription initiation, DNA-dependent|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|transcription from RNA polymerase II promoter	cytosol|nucleoplasm	protein domain specific binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|TBP-class protein binding|thyroid hormone binding|thyroid hormone receptor activity|transcription regulatory region DNA binding|zinc ion binding			endometrium(1)|kidney(3)|large_intestine(2)|lung(4)|prostate(1)	11	Colorectal(19;0.000442)	Myeloproliferative disorder(1115;0.0255)			Levothyroxine(DB00451)|Liothyronine(DB00279)	TTCCTCGAGGTCTTTGAGGATCAG	0.637													22	50	---	---	---	---