Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
SLC30A3	7781	broad.mit.edu	37	2	27480105	27480105	+	Missense_Mutation	SNP	C	C	T			TCGA-DU-A7T6-01A-11D-A33T-08	TCGA-DU-A7T6-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	675ce5ef-043a-4057-854c-dc78c82c3138	f00ed66c-116a-4665-b75d-7f5d608e7034	g.chr2:27480105C>T	ENST00000233535.4	-	5	1046	c.694G>A	c.(694-696)Gtc>Atc	p.V232I	SLC30A3_ENST00000447008.2_Missense_Mutation_p.V227I	NM_003459.4	NP_003450.2	Q99726	ZNT3_HUMAN	solute carrier family 30 (zinc transporter), member 3	232					regulation of sequestering of zinc ion	cell junction|integral to plasma membrane|late endosome|membrane fraction|synaptic vesicle membrane	zinc transporting ATPase activity			NS(1)|breast(1)|cervix(1)|endometrium(2)|large_intestine(3)|lung(11)|pancreas(1)	20	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GCCGCCCGGACGCTGGTGTTC	0.647000													20	36					0	0	1	0	0
VWF	7450	broad.mit.edu	37	12	6103064	6103064	+	Missense_Mutation	SNP	C	C	T			TCGA-DU-A7T6-01A-11D-A33T-08	TCGA-DU-A7T6-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	675ce5ef-043a-4057-854c-dc78c82c3138	f00ed66c-116a-4665-b75d-7f5d608e7034	g.chr12:6103064C>T	ENST00000261405.5	-	37	6816	c.6562G>A	c.(6562-6564)Ggg>Agg	p.G2188R		NM_000552.3	NP_000543.2	P04275	VWF_HUMAN	von Willebrand factor	2188					blood coagulation, intrinsic pathway|cell-substrate adhesion|platelet activation|platelet degranulation|protein homooligomerization	endoplasmic reticulum|platelet alpha granule lumen|proteinaceous extracellular matrix|Weibel-Palade body	chaperone binding|collagen binding|glycoprotein binding|immunoglobulin binding|integrin binding|protease binding|protein homodimerization activity|protein N-terminus binding			NS(1)|breast(6)|central_nervous_system(5)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(25)|lung(41)|ovary(7)|pancreas(2)|prostate(6)|skin(15)|stomach(1)|upper_aerodigestive_tract(5)	129					Antihemophilic Factor(DB00025)	ACGCAGACCCCGTTGGTCCGA	0.557000													16	49					0	0	1	0	0
ATP8A2	51761	broad.mit.edu	37	13	26411376	26411376	+	Missense_Mutation	SNP	C	C	T			TCGA-DU-A7T6-01A-11D-A33T-08	TCGA-DU-A7T6-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	675ce5ef-043a-4057-854c-dc78c82c3138	f00ed66c-116a-4665-b75d-7f5d608e7034	g.chr13:26411376C>T	ENST00000381655.2	+	29	2972	c.2830C>T	c.(2830-2832)Ccc>Tcc	p.P944S	ATP8A2_ENST00000491840.1_3'UTR|ATP8A2_ENST00000255283.8_Missense_Mutation_p.P879S	NM_016529.4	NP_057613.4	Q9NTI2	AT8A2_HUMAN	ATPase, aminophospholipid transporter, class I, type 8A, member 2	904					ATP biosynthetic process|negative regulation of cell proliferation	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity	p.P944S(1)		breast(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(17)|lung(31)|ovary(4)|skin(3)|stomach(1)|urinary_tract(1)	72		Breast(139;0.0201)|Lung SC(185;0.0225)		all cancers(112;0.043)|OV - Ovarian serous cystadenocarcinoma(117;0.0748)|Epithelial(112;0.079)		GCTCAGGTTTCCCCAGCTCTA	0.493000													16	133					0	0	1	0	0
SLC22A18	5002	broad.mit.edu	37	11	2940615	2940615	+	Missense_Mutation	SNP	C	C	G			TCGA-DU-A7T6-01A-11D-A33T-08	TCGA-DU-A7T6-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	675ce5ef-043a-4057-854c-dc78c82c3138	f00ed66c-116a-4665-b75d-7f5d608e7034	g.chr11:2940615C>G	ENST00000380574.1	+	8	1273	c.842C>G	c.(841-843)tCc>tGc	p.S281C	SLC22A18_ENST00000312221.5_Missense_Mutation_p.S281C|SLC22A18_ENST00000441077.1_3'UTR|SLC22A18_ENST00000449793.2_Missense_Mutation_p.S183C|SLC22A18_ENST00000347936.2_Missense_Mutation_p.S281C			Q96BI1	S22AI_HUMAN	solute carrier family 22, member 18	281					excretion|organic cation transport	apical plasma membrane|cytoplasmic part|integral to membrane|nuclear envelope	drug:hydrogen antiporter activity|symporter activity|ubiquitin protein ligase binding			central_nervous_system(2)|large_intestine(1)|lung(3)|ovary(1)|prostate(1)	8		all_epithelial(84;0.000124)|Medulloblastoma(188;0.00106)|Breast(177;0.00328)|Ovarian(85;0.00556)|all_neural(188;0.00681)|all_lung(207;0.198)		BRCA - Breast invasive adenocarcinoma(625;0.00256)|LUSC - Lung squamous cell carcinoma(625;0.192)		TACCTCATGTCCTTCTTCGGG	0.632000													15	118					0	0	1	0	0
HTR1F	3355	broad.mit.edu	37	3	88040261	88040261	+	Missense_Mutation	SNP	G	G	A			TCGA-DU-A7T6-01A-11D-A33T-08	TCGA-DU-A7T6-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	675ce5ef-043a-4057-854c-dc78c82c3138	f00ed66c-116a-4665-b75d-7f5d608e7034	g.chr3:88040261G>A	ENST00000319595.4	+	1	416	c.362G>A	c.(361-363)cGg>cAg	p.R121Q		NM_000866.3	NP_000857.1	P30939	5HT1F_HUMAN	5-hydroxytryptamine (serotonin) receptor 1F, G protein-coupled	121					G-protein signaling, coupled to cyclic nucleotide second messenger|synaptic transmission	integral to plasma membrane	serotonin binding|serotonin receptor activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(12)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)	25	all_cancers(8;0.147)	Lung NSC(201;0.0283)		LUSC - Lung squamous cell carcinoma(29;0.00353)|Lung(72;0.00664)	Eletriptan(DB00216)|Naratriptan(DB00952)|Rizatriptan(DB00953)|Sumatriptan(DB00669)|Zolmitriptan(DB00315)	GCTTTGGATCGGTATCGAGCA	0.438000													27	72					0	0	1	0	0
SREBF2	6721	broad.mit.edu	37	22	42280888	42280888	+	Missense_Mutation	SNP	C	C	T			TCGA-DU-A7T6-01A-11D-A33T-08	TCGA-DU-A7T6-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	675ce5ef-043a-4057-854c-dc78c82c3138	f00ed66c-116a-4665-b75d-7f5d608e7034	g.chr22:42280888C>T	ENST00000361204.4	+	11	2247	c.2081C>T	c.(2080-2082)gCg>gTg	p.A694V		NM_004599.2	NP_004590.2	Q12772	SRBP2_HUMAN	sterol regulatory element binding transcription factor 2	694					cholesterol metabolic process	ER to Golgi transport vesicle membrane|Golgi membrane|nucleus|SREBP-SCAP-Insig complex	protein C-terminus binding			NS(2)|breast(6)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(9)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	38						GTACACATGGCGTTGTGTGCC	0.547000													4	89					0	0	1	0	0
ATP2B3	492	broad.mit.edu	37	X	152826216	152826216	+	Silent	SNP	C	C	T			TCGA-DU-A7T6-01A-11D-A33T-08	TCGA-DU-A7T6-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	675ce5ef-043a-4057-854c-dc78c82c3138	f00ed66c-116a-4665-b75d-7f5d608e7034	g.chrX:152826216C>T	ENST00000370186.1	+	17	3206	c.2880C>T	c.(2878-2880)aaC>aaT	p.N960N	ATP2B3_ENST00000393842.1_Silent_p.N960N|ATP2B3_ENST00000370181.2_Silent_p.N960N|ATP2B3_ENST00000359149.3_Silent_p.N974N|ATP2B3_ENST00000349466.2_Silent_p.N974N|ATP2B3_ENST00000263519.4_Silent_p.N974N|ATP2B3_ENST00000460549.1_3'UTR			Q16720	AT2B3_HUMAN	ATPase, Ca++ transporting, plasma membrane 3	974					ATP biosynthetic process|platelet activation	integral to membrane|plasma membrane	ATP binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding			NS(2)|breast(5)|endometrium(7)|large_intestine(8)|lung(23)|ovary(1)|pancreas(1)|skin(3)	50	all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					TCATCTTCAACACGTTCGTCA	0.557000													49	87					0	0	1	0	0
TAF1B	9014	broad.mit.edu	37	2	10008510	10008510	+	Missense_Mutation	SNP	G	G	A			TCGA-DU-A7T6-01A-11D-A33T-08	TCGA-DU-A7T6-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	675ce5ef-043a-4057-854c-dc78c82c3138	f00ed66c-116a-4665-b75d-7f5d608e7034	g.chr2:10008510G>A	ENST00000263663.5	+	6	693	c.505G>A	c.(505-507)Gac>Aac	p.D169N	TAF1B_ENST00000402170.1_3'UTR|TAF1B_ENST00000396242.3_5'UTR	NM_005680.2	NP_005671.2	Q53T94	TAF1B_HUMAN	TATA box binding protein (TBP)-associated factor, RNA polymerase I, B, 63kDa	169					termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription initiation from RNA polymerase I promoter	nucleoplasm	DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(1)|lung(4)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	14	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)					GTCTCAGTCTGACATCCACAC	0.438000													53	67					0	0	1	0	0
LRRC18	474354	broad.mit.edu	37	10	50122062	50122062	+	Missense_Mutation	SNP	G	G	C			TCGA-DU-A7T6-01A-11D-A33T-08	TCGA-DU-A7T6-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	675ce5ef-043a-4057-854c-dc78c82c3138	f00ed66c-116a-4665-b75d-7f5d608e7034	g.chr10:50122062G>C	ENST00000374160.3	-	1	215	c.139C>G	c.(139-141)Ctg>Gtg	p.L47V	LRRC18_ENST00000298124.3_Missense_Mutation_p.L47V|WDFY4_ENST00000325239.5_Intron|WDFY4_ENST00000413659.2_Intron|RP11-523O18.7_ENST00000430438.1_RNA	NM_001006939.3	NP_001006940.3	Q8N456	LRC18_HUMAN	leucine rich repeat containing 18	47						cytoplasm				NS(1)|endometrium(3)|kidney(1)|large_intestine(3)|lung(5)|ovary(2)|pancreas(1)|prostate(1)|skin(1)	18						CTAAGGCGCAGAATACACTTG	0.507000													28	144					0	0	1	0	0
TIAM1	7074	broad.mit.edu	37	21	32493110	32493110	+	Missense_Mutation	SNP	G	G	A			TCGA-DU-A7T6-01A-11D-A33T-08	TCGA-DU-A7T6-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	675ce5ef-043a-4057-854c-dc78c82c3138	f00ed66c-116a-4665-b75d-7f5d608e7034	g.chr21:32493110G>A	ENST00000286827.3	-	29	4823	c.4352C>T	c.(4351-4353)gCt>gTt	p.A1451V	TIAM1_ENST00000541036.1_Missense_Mutation_p.A1391V	NM_003253.2	NP_003244.2	Q13009	TIAM1_HUMAN	T-cell lymphoma invasion and metastasis 1	1451					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cell-cell junction|cytosol	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity	p.A1451G(2)		autonomic_ganglia(3)|breast(7)|central_nervous_system(2)|endometrium(13)|kidney(4)|large_intestine(33)|lung(44)|ovary(2)|prostate(3)|skin(2)|urinary_tract(2)	115						CCTGTTTCGAGCCAGCCGCCG	0.547000													14	63					0	0	1	0	0
LRRIQ4	344657	broad.mit.edu	37	3	169540297	169540297	+	Silent	SNP	C	C	T			TCGA-DU-A7T6-01A-11D-A33T-08	TCGA-DU-A7T6-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	675ce5ef-043a-4057-854c-dc78c82c3138	f00ed66c-116a-4665-b75d-7f5d608e7034	g.chr3:169540297C>T	ENST00000340806.6	+	1	588	c.588C>T	c.(586-588)gaC>gaT	p.D196D		NM_001080460.1	NP_001073929.1	A6NIV6	LRIQ4_HUMAN	leucine-rich repeats and IQ motif containing 4	196								p.D196D(1)		breast(2)|endometrium(2)|kidney(2)|large_intestine(6)|lung(14)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	30						TTGACCTGGACGAGAACAAAA	0.517000													47	114					0	0	1	0	0
PKD1	5310	broad.mit.edu	37	16	2159762	2159762	+	Silent	SNP	C	C	G			TCGA-DU-A7T6-01A-11D-A33T-08	TCGA-DU-A7T6-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	675ce5ef-043a-4057-854c-dc78c82c3138	f00ed66c-116a-4665-b75d-7f5d608e7034	g.chr16:2159762C>G	ENST00000262304.4	-	15	5614	c.5406G>C	c.(5404-5406)gtG>gtC	p.V1802V	PKD1_ENST00000423118.1_Silent_p.V1802V	NM_001009944.2	NP_001009944.2	P98161	PKD1_HUMAN	polycystic kidney disease 1 (autosomal dominant)	1802	PKD 13.				calcium-independent cell-matrix adhesion|homophilic cell adhesion|neuropeptide signaling pathway	basolateral plasma membrane|integral to plasma membrane	protein domain specific binding|sugar binding			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(7)|kidney(6)|lung(34)|prostate(4)|skin(10)|upper_aerodigestive_tract(3)|urinary_tract(3)	72						TGAGGCCACTCACAGGCACCT	0.667000													9	20					0	0	1	0	0
CCDC73	493860	broad.mit.edu	37	11	32635985	32635985	+	Missense_Mutation	SNP	C	C	T			TCGA-DU-A7T6-01A-11D-A33T-08	TCGA-DU-A7T6-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	675ce5ef-043a-4057-854c-dc78c82c3138	f00ed66c-116a-4665-b75d-7f5d608e7034	g.chr11:32635985C>T	ENST00000335185.5	-	16	1922	c.1879G>A	c.(1879-1881)Gca>Aca	p.A627T		NM_001008391.2	NP_001008392.2	Q6ZRK6	CCD73_HUMAN	coiled-coil domain containing 73	627										NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(9)|lung(20)|ovary(2)|prostate(2)|skin(2)|stomach(1)|urinary_tract(2)	51	Breast(20;0.112)					TCCAAATCTGCTTTGGTTTGG	0.343000													4	154					0	0	1	0	0
PCBP4	57060	broad.mit.edu	37	3	51992879	51992879	+	Missense_Mutation	SNP	C	C	G			TCGA-DU-A7T6-01A-11D-A33T-08	TCGA-DU-A7T6-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	675ce5ef-043a-4057-854c-dc78c82c3138	f00ed66c-116a-4665-b75d-7f5d608e7034	g.chr3:51992879C>G	ENST00000461554.1	-	13	1181	c.850G>C	c.(850-852)Gct>Cct	p.A284P	PCBP4_ENST00000395014.2_Missense_Mutation_p.A305P|PCBP4_ENST00000484633.1_Missense_Mutation_p.A241P|PCBP4_ENST00000322099.7_Missense_Mutation_p.A284P|PCBP4_ENST00000471622.1_Missense_Mutation_p.A284P|PCBP4_ENST00000355852.2_Missense_Mutation_p.A284P|PCBP4_ENST00000395013.3_Missense_Mutation_p.A124P|PCBP4_ENST00000428823.2_Missense_Mutation_p.A241P	NM_001174100.1	NP_001167571.1	P57723	PCBP4_HUMAN	poly(rC) binding protein 4	284	KH 3.					cytoplasm|ribonucleoprotein complex	DNA binding|RNA binding			endometrium(2)|large_intestine(2)|lung(2)|prostate(1)|stomach(1)	8				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.000534)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)		CGCTCCCCAGCGCCCTCTGCT	0.637000													18	123					0	0	1	0	0
KRT36	8689	broad.mit.edu	37	17	39646040	39646040	+	Missense_Mutation	SNP	G	G	C			TCGA-DU-A7T6-01A-11D-A33T-08	TCGA-DU-A7T6-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	675ce5ef-043a-4057-854c-dc78c82c3138	f00ed66c-116a-4665-b75d-7f5d608e7034	g.chr17:39646040G>C	ENST00000328119.6	-	1	76	c.77C>G	c.(76-78)tCt>tGt	p.S26C	KRT36_ENST00000393986.2_Intron	NM_003771.4	NP_003762.1	O76013	KRT36_HUMAN	keratin 36	26	Head.					intermediate filament	protein binding|structural constituent of epidermis			breast(2)|cervix(1)|kidney(2)|large_intestine(3)|lung(8)|skin(1)	17		Breast(137;0.000286)				GGACACCCGAGAGATGCCGCC	0.627000													12	85					0	0	1	0	0
ZAN	7455	broad.mit.edu	37	7	100334235	100334235	+	RNA	SNP	G	G	A			TCGA-DU-A7T6-01A-11D-A33T-08	TCGA-DU-A7T6-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	675ce5ef-043a-4057-854c-dc78c82c3138	f00ed66c-116a-4665-b75d-7f5d608e7034	g.chr7:100334235G>A	ENST00000542585.1	+	0	384				ZAN_ENST00000349350.6_RNA|ZAN_ENST00000546292.1_RNA|ZAN_ENST00000421100.1_RNA|ZAN_ENST00000348028.3_RNA|ZAN_ENST00000449052.1_RNA|ZAN_ENST00000538115.1_RNA|ZAN_ENST00000443370.1_RNA|ZAN_ENST00000427578.1_RNA|ZAN_ENST00000546213.1_RNA	NM_003386.1	NP_003377.1	Q9Y493	ZAN_HUMAN	zonadhesin (gene/pseudogene)						binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				NS(2)|breast(3)|central_nervous_system(3)|endometrium(21)|kidney(6)|large_intestine(18)|lung(60)|ovary(4)|pancreas(3)|prostate(5)|skin(8)|stomach(3)|upper_aerodigestive_tract(3)	139	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			GGGGCCCCCGGGGGGTACCCT	0.662000													71	19					0	0	1	0	0
MBOAT2	129642	broad.mit.edu	37	2	8998901	8998901	+	Missense_Mutation	SNP	T	T	A			TCGA-DU-A7T6-01A-11D-A33T-08	TCGA-DU-A7T6-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	675ce5ef-043a-4057-854c-dc78c82c3138	f00ed66c-116a-4665-b75d-7f5d608e7034	g.chr2:8998901T>A	ENST00000305997.3	-	13	1669	c.1471A>T	c.(1471-1473)Aat>Tat	p.N491Y		NM_138799.2	NP_620154.2	Q6ZWT7	MBOA2_HUMAN	membrane bound O-acyltransferase domain containing 2	491					phospholipid biosynthetic process	integral to membrane	1-acylglycerol-3-phosphate O-acyltransferase activity		MBOAT2/PRKCE(2)	endometrium(2)|kidney(1)|large_intestine(9)|lung(2)|skin(1)	15	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)					CCCAAAGAATTTTCTCCTTCA	0.348000													59	85					0	0	1	0	0
TBR1	10716	broad.mit.edu	37	2	162279930	162279930	+	Missense_Mutation	SNP	C	C	G			TCGA-DU-A7T6-01A-11D-A33T-08	TCGA-DU-A7T6-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	675ce5ef-043a-4057-854c-dc78c82c3138	f00ed66c-116a-4665-b75d-7f5d608e7034	g.chr2:162279930C>G	ENST00000389554.3	+	6	1558	c.1241C>G	c.(1240-1242)tCg>tGg	p.S414W	TBR1_ENST00000489530.1_3'UTR|TBR1_ENST00000410035.1_Missense_Mutation_p.S127W|AC009487.4_ENST00000437683.1_RNA	NM_006593.2	NP_006584.1	Q16650	TBR1_HUMAN	T-box, brain, 1	414						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(6)|lung(15)|ovary(1)|prostate(1)|skin(3)	30						CCCAACGACTCGCCGCGCTCG	0.687000													7	68					0	0	1	0	0
RP11-798G7.5	0	broad.mit.edu	37	17	43587730	43587730	+	RNA	SNP	A	A	C	rs142536398	by1000genomes	TCGA-DU-A7T6-01A-11D-A33T-08	TCGA-DU-A7T6-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	675ce5ef-043a-4057-854c-dc78c82c3138	f00ed66c-116a-4665-b75d-7f5d608e7034	g.chr17:43587730A>C	ENST00000253803.2	+	0	267				LRRC37A4P_ENST00000579913.1_RNA																							GTATTGATTCATTTTATTCAT	0.343000													3	87					0	0	1	0	0
GINS4	84296	broad.mit.edu	37	8	41397213	41397213	+	Missense_Mutation	SNP	C	C	T			TCGA-DU-A7T6-01A-11D-A33T-08	TCGA-DU-A7T6-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	675ce5ef-043a-4057-854c-dc78c82c3138	f00ed66c-116a-4665-b75d-7f5d608e7034	g.chr8:41397213C>T	ENST00000523277.2	+	5	481	c.314C>T	c.(313-315)cCt>cTt	p.P105L	RP11-360L9.4_ENST00000523081.1_RNA|GINS4_ENST00000276533.3_Missense_Mutation_p.P105L|GINS4_ENST00000518671.1_Missense_Mutation_p.P105L			Q9BRT9	SLD5_HUMAN	GINS complex subunit 4 (Sld5 homolog)	105					DNA strand elongation involved in DNA replication|S phase of mitotic cell cycle	cytoplasm|nucleoplasm				breast(1)|lung(2)|skin(1)	4	Ovarian(28;0.014)|Colorectal(14;0.0202)|Lung SC(25;0.211)	all_lung(54;0.00732)|Lung NSC(58;0.0207)|Hepatocellular(245;0.0462)|Esophageal squamous(32;0.0844)	Colorectal(10;0.0014)|OV - Ovarian serous cystadenocarcinoma(14;0.00329)|LUSC - Lung squamous cell carcinoma(45;0.0137)|COAD - Colon adenocarcinoma(11;0.0147)			AAGTTTTTCCCTCATGTCCTT	0.458000													86	108					0	0	1	0	0
CELSR2	1952	broad.mit.edu	37	1	109792762	109792762	+	Silent	SNP	T	T	C			TCGA-DU-A7T6-01A-11D-A33T-08	TCGA-DU-A7T6-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	675ce5ef-043a-4057-854c-dc78c82c3138	f00ed66c-116a-4665-b75d-7f5d608e7034	g.chr1:109792762T>C	ENST00000271332.3	+	1	122	c.61T>C	c.(61-63)Ttg>Ctg	p.L21L		NM_001408.2	NP_001399.1	Q9HCU4	CELR2_HUMAN	cadherin, EGF LAG seven-pass G-type receptor 2	21					dendrite morphogenesis|homophilic cell adhesion|neural plate anterior/posterior regionalization|neuropeptide signaling pathway|regulation of cell-cell adhesion|regulation of transcription, DNA-dependent|Wnt receptor signaling pathway	cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			NS(1)|autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(14)|lung(27)|ovary(5)|prostate(1)|skin(3)|urinary_tract(2)	82		all_epithelial(167;0.000114)|all_lung(203;0.000321)|Lung NSC(277;0.000626)|Breast(1374;0.244)		Colorectal(144;0.0296)|Lung(183;0.067)|COAD - Colon adenocarcinoma(174;0.114)|Epithelial(280;0.193)|all cancers(265;0.219)		gctgctgctgttgctgctgct	0.746000													3	25					0	0	1	0	0
TRIM33	51592	broad.mit.edu	37	1	114964058	114964058	+	Splice_Site	SNP	C	C	A			TCGA-DU-A7T6-01A-11D-A33T-08	TCGA-DU-A7T6-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	675ce5ef-043a-4057-854c-dc78c82c3138	f00ed66c-116a-4665-b75d-7f5d608e7034	g.chr1:114964058C>A	ENST00000358465.2	-	11	2144	c.2061_splice	c.e11+1	p.Q687_splice	TRIM33_ENST00000369543.2_Splice_Site_p.Q687_splice|TRIM33_ENST00000450349.2_Splice_Site_p.Q295_splice	NM_015906.3	NP_056990.3	Q9UPN9	TRI33_HUMAN	tripartite motif containing 33	687					negative regulation of BMP signaling pathway|negative regulation of transcription, DNA-dependent|protein ubiquitination|regulation of transforming growth factor beta receptor signaling pathway|transcription, DNA-dependent	nucleus	co-SMAD binding|DNA binding|ligase activity|R-SMAD binding|zinc ion binding			breast(2)|central_nervous_system(5)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(10)|lung(14)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	48	all_epithelial(7;0.000132)|all_lung(7;0.00106)|Lung SC(450;0.184)	all_cancers(81;3.03e-08)|all_epithelial(167;3.24e-08)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		AAATACAAACCTGTATGGGTG	0.378000			T	RET	papillary thyroid								65	60					1.33661e-31	1.41734e-31	1	1	0
TNFSF14	0	broad.mit.edu	37	19	6664977	6664977	+	Missense_Mutation	SNP	C	C	T			TCGA-DU-A7T6-01A-11D-A33T-08	TCGA-DU-A7T6-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	675ce5ef-043a-4057-854c-dc78c82c3138	f00ed66c-116a-4665-b75d-7f5d608e7034	g.chr19:6664977C>T	ENST00000326176.9	-	5	956	c.575G>A	c.(574-576)cGt>cAt	p.R192H	TNFSF14_ENST00000599359.1_Missense_Mutation_p.R228H|TNFSF14_ENST00000245912.3_Missense_Mutation_p.R192H	NM_003807.3|NM_172014.2	NP_003798.2|NP_742011.2	O43557	TNF14_HUMAN	tumor necrosis factor (ligand) superfamily, member 14	228					cellular response to mechanical stimulus|immune response|induction of apoptosis|release of cytoplasmic sequestered NF-kappaB|T cell homeostasis|T cell proliferation	cytoplasm|extracellular space|integral to membrane|plasma membrane	caspase inhibitor activity|cytokine activity|tumor necrosis factor receptor binding			breast(1)|kidney(2)|large_intestine(4)|liver(1)|lung(4)|ovary(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	18						GGTACCATCACGCAGTCGAAC	0.602000													40	125					0	0	1	0	0
CXCL1	2919	broad.mit.edu	37	4	74735501	74735501	+	Silent	SNP	C	C	G			TCGA-DU-A7T6-01A-11D-A33T-08	TCGA-DU-A7T6-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	675ce5ef-043a-4057-854c-dc78c82c3138	f00ed66c-116a-4665-b75d-7f5d608e7034	g.chr4:74735501C>G	ENST00000395761.3	+	2	283	c.216C>G	c.(214-216)acC>acG	p.T72T	CXCL1_ENST00000509101.1_3'UTR	NM_001511.3	NP_001502.1	P09341	GROA_HUMAN	chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)	72					actin cytoskeleton organization|cell proliferation|chemotaxis|G-protein coupled receptor protein signaling pathway|immune response|inflammatory response|intracellular signal transduction|negative regulation of cell proliferation|nervous system development	extracellular space|intracellular	chemokine activity|enzyme activator activity|growth factor activity			lung(2)	2	Breast(15;0.00102)		all cancers(17;0.00176)|Lung(101;0.128)|LUSC - Lung squamous cell carcinoma(112;0.187)			GCGCCCAAACCGAAGTCATGT	0.652000													26	175					0	0	1	0	0
HTR5A	3361	broad.mit.edu	37	7	154862767	154862767	+	Missense_Mutation	SNP	C	C	T			TCGA-DU-A7T6-01A-11D-A33T-08	TCGA-DU-A7T6-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	675ce5ef-043a-4057-854c-dc78c82c3138	f00ed66c-116a-4665-b75d-7f5d608e7034	g.chr7:154862767C>T	ENST00000287907.2	+	1	734	c.158C>T	c.(157-159)gCg>gTg	p.A53V	AC093726.4_ENST00000395731.2_Missense_Mutation_p.A83T|AC093726.4_ENST00000493904.1_5'UTR|AC093726.4_ENST00000543018.1_Missense_Mutation_p.A83T	NM_024012.3	NP_076917.1	P47898	5HT5A_HUMAN	5-hydroxytryptamine (serotonin) receptor 5A, G protein-coupled	53						integral to plasma membrane	serotonin receptor activity			NS(1)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(22)|ovary(2)|prostate(3)|stomach(1)	48	all_neural(206;0.119)	all_hematologic(28;0.0592)	OV - Ovarian serous cystadenocarcinoma(82;0.0238)	UCEC - Uterine corpus endometrioid carcinoma (81;0.171)		CTGGTGGCGGCGACGTTCGCC	0.642000													8	80					0	0	1	0	0
TSPAN12	23554	broad.mit.edu	37	7	120478922	120478922	+	Missense_Mutation	SNP	G	G	A			TCGA-DU-A7T6-01A-11D-A33T-08	TCGA-DU-A7T6-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	675ce5ef-043a-4057-854c-dc78c82c3138	f00ed66c-116a-4665-b75d-7f5d608e7034	g.chr7:120478922G>A	ENST00000222747.3	-	4	801	c.194C>T	c.(193-195)cCg>cTg	p.P65L	TSPAN12_ENST00000415871.1_Missense_Mutation_p.P65L	NM_012338.3	NP_036470.1	O95859	TSN12_HUMAN	tetraspanin 12	65					angiogenesis|cell surface receptor linked signaling pathway|regulation of angiogenesis|retina layer formation	integral to plasma membrane|membrane fraction		p.P65Q(1)		endometrium(3)|kidney(1)|lung(4)|ovary(1)|skin(1)	10	all_neural(327;0.117)					AATCATGACCGGATGAACCAC	0.373000													4	324					0	0	1	0	0
LRRC36	55282	broad.mit.edu	37	16	67401214	67401214	+	Missense_Mutation	SNP	G	G	A			TCGA-DU-A7T6-01A-11D-A33T-08	TCGA-DU-A7T6-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	675ce5ef-043a-4057-854c-dc78c82c3138	f00ed66c-116a-4665-b75d-7f5d608e7034	g.chr16:67401214G>A	ENST00000329956.6	+	8	1068	c.1049G>A	c.(1048-1050)aGg>aAg	p.R350K	LRRC36_ENST00000290940.7_Missense_Mutation_p.R82K|LRRC36_ENST00000541146.1_Intron|LRRC36_ENST00000563189.1_Missense_Mutation_p.R229K|LRRC36_ENST00000435835.3_Missense_Mutation_p.R229K	NM_018296.5	NP_060766.5	Q1X8D7	LRC36_HUMAN	leucine rich repeat containing 36	350										endometrium(4)|kidney(2)|large_intestine(5)|lung(4)|ovary(1)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)	24		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0669)|Epithelial(162;0.161)		CTTGGTAAAAGGCCTCAGAGA	0.408000													15	356					0	0	1	0	0
PCDHB15	0	broad.mit.edu	37	5	140627084	140627084	+	Missense_Mutation	SNP	C	C	G			TCGA-DU-A7T6-01A-11D-A33T-08	TCGA-DU-A7T6-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	675ce5ef-043a-4057-854c-dc78c82c3138	f00ed66c-116a-4665-b75d-7f5d608e7034	g.chr5:140627084C>G	ENST00000231173.3	+	1	1938	c.1938C>G	c.(1936-1938)gaC>gaG	p.D646E		NM_018935.2	NP_061758.1	Q9Y5E8	PCDBF_HUMAN		646	Cadherin 6.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			NS(1)|breast(3)|endometrium(8)|kidney(3)|large_intestine(14)|liver(1)|lung(18)|ovary(3)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)	61			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TGGTCAAGGACAATGGCGAGC	0.706000													35	116					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179453777	179453777	+	Missense_Mutation	SNP	C	C	T			TCGA-DU-A7T6-01A-11D-A33T-08	TCGA-DU-A7T6-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	675ce5ef-043a-4057-854c-dc78c82c3138	f00ed66c-116a-4665-b75d-7f5d608e7034	g.chr2:179453777C>T	ENST00000589042.1	-	304	62899	c.62675G>A	c.(62674-62676)gGt>gAt	p.G20892D	TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000590932.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.G11827D|TTN-AS1_ENST00000456053.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.G11952D|TTN_ENST00000342992.6_Missense_Mutation_p.G18324D|TTN-AS1_ENST00000589907.1_RNA|TTN-AS1_ENST00000590743.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.G12019D|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.G19251D|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000586452.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	19251	Fibronectin type-III 51.		T -> N.				ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTCACAGCCACCATCATCTTC	0.403000													11	53					0	0	1	0	0
C17orf53	78995	broad.mit.edu	37	17	42225301	42225301	+	Missense_Mutation	SNP	C	C	T	rs147787171	byFrequency	TCGA-DU-A7T6-01A-11D-A33T-08	TCGA-DU-A7T6-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	675ce5ef-043a-4057-854c-dc78c82c3138	f00ed66c-116a-4665-b75d-7f5d608e7034	g.chr17:42225301C>T	ENST00000319977.4	+	3	367	c.130C>T	c.(130-132)Cct>Tct	p.P44S	C17orf53_ENST00000585683.1_Missense_Mutation_p.P44S|C17orf53_ENST00000245382.6_Missense_Mutation_p.P44S	NM_001171251.1|NM_024032.3	NP_001164722.1|NP_076937.2	Q8N3J3	CQ053_HUMAN	chromosome 17 open reading frame 53	44										NS(1)|breast(3)|cervix(1)|kidney(3)|large_intestine(3)|lung(8)|ovary(1)|skin(1)|urinary_tract(1)	22		Breast(137;0.0364)|Prostate(33;0.0376)		BRCA - Breast invasive adenocarcinoma(366;0.114)		GCGCCTGAGACCTGTCTCTTC	0.567000													43	98					0	0	1	0	0
KCNN2	3781	broad.mit.edu	37	5	113698753	113698753	+	Missense_Mutation	SNP	G	G	C			TCGA-DU-A7T6-01A-11D-A33T-08	TCGA-DU-A7T6-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	675ce5ef-043a-4057-854c-dc78c82c3138	f00ed66c-116a-4665-b75d-7f5d608e7034	g.chr5:113698753G>C	ENST00000512097.3	+	2	1299	c.281G>C	c.(280-282)gGc>gCc	p.G94A	KCNN2_ENST00000264773.3_Missense_Mutation_p.G94A			Q9H2S1	KCNN2_HUMAN	potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2	94	Poly-Gly.					integral to membrane	calmodulin binding|small conductance calcium-activated potassium channel activity			breast(1)|endometrium(5)|kidney(2)|large_intestine(7)|lung(21)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	45		all_cancers(142;2.86e-05)|all_epithelial(76;9.33e-06)|Prostate(80;0.00955)|Ovarian(225;0.0444)|Breast(839;0.159)|Lung NSC(810;0.174)|all_lung(232;0.206)		OV - Ovarian serous cystadenocarcinoma(64;1.89e-08)|Epithelial(69;2.04e-08)|all cancers(49;3.74e-06)|COAD - Colon adenocarcinoma(37;0.142)|Colorectal(14;0.195)		ggaggaggcggcggcggtggc	0.652000													7	28					0	0	1	0	0
SLC35F5	80255	broad.mit.edu	37	2	114508047	114508047	+	Nonsense_Mutation	SNP	C	C	T			TCGA-DU-A7T6-01A-11D-A33T-08	TCGA-DU-A7T6-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	675ce5ef-043a-4057-854c-dc78c82c3138	f00ed66c-116a-4665-b75d-7f5d608e7034	g.chr2:114508047C>T	ENST00000245680.2	-	4	785	c.372G>A	c.(370-372)tgG>tgA	p.W124*	SLC35F5_ENST00000409342.1_Nonsense_Mutation_p.W118*	NM_025181.2	NP_079457.2	Q8WV83	S35F5_HUMAN	solute carrier family 35, member F5	124					transport	integral to membrane				endometrium(1)|kidney(4)|large_intestine(2)|lung(7)|ovary(2)|prostate(3)|skin(1)	20						ACTGTTGTCTCCATGGCTTCC	0.368000													50	67					0	0	1	0	0
TRPM8	79054	broad.mit.edu	37	2	234869448	234869448	+	Missense_Mutation	SNP	C	C	T	rs143538093		TCGA-DU-A7T6-01A-11D-A33T-08	TCGA-DU-A7T6-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	675ce5ef-043a-4057-854c-dc78c82c3138	f00ed66c-116a-4665-b75d-7f5d608e7034	g.chr2:234869448C>T	ENST00000324695.4	+	12	1431	c.1391C>T	c.(1390-1392)aCg>aTg	p.T464M	TRPM8_ENST00000433712.2_Missense_Mutation_p.T152M	NM_024080.4	NP_076985.4	Q7Z2W7	TRPM8_HUMAN	transient receptor potential cation channel, subfamily M, member 8	464						integral to membrane				breast(5)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(15)|liver(2)|lung(27)|prostate(2)|skin(7)|stomach(2)	66		Breast(86;0.00205)|Renal(207;0.00694)|all_lung(227;0.0129)|Lung NSC(271;0.0408)|all_hematologic(139;0.0753)|Acute lymphoblastic leukemia(138;0.224)		Epithelial(121;1.19e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000139)|Lung(119;0.00758)|LUSC - Lung squamous cell carcinoma(224;0.0108)	Menthol(DB00825)	GTCATGTTTACGGCTCTCATA	0.423000													4	134					0	0	1	0	0
GPRASP1	9737	broad.mit.edu	37	X	101909040	101909040	+	Nonsense_Mutation	SNP	G	G	T			TCGA-DU-A7T6-01A-11D-A33T-08	TCGA-DU-A7T6-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	675ce5ef-043a-4057-854c-dc78c82c3138	f00ed66c-116a-4665-b75d-7f5d608e7034	g.chrX:101909040G>T	ENST00000537097.1	+	6	1012	c.199G>T	c.(199-201)Gag>Tag	p.E67*	RP4-769N13.7_ENST00000602441.1_RNA|GPRASP1_ENST00000361600.5_Nonsense_Mutation_p.E67*|GPRASP1_ENST00000444152.1_Nonsense_Mutation_p.E67*|GPRASP1_ENST00000415986.1_Nonsense_Mutation_p.E67*	NM_001184727.1	NP_001171656.1	Q5JY77	GASP1_HUMAN	G protein-coupled receptor associated sorting protein 1	67						cytoplasm	protein binding			NS(1)|breast(3)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(10)|lung(29)|ovary(2)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	60						CACCAAAGTTGAGACAAGTGC	0.542000													8	320					0.000157383	0.000159401	1	1	0
MED13	9969	broad.mit.edu	37	17	60140431	60140431	+	Missense_Mutation	SNP	A	A	G			TCGA-DU-A7T6-01A-11D-A33T-08	TCGA-DU-A7T6-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	675ce5ef-043a-4057-854c-dc78c82c3138	f00ed66c-116a-4665-b75d-7f5d608e7034	g.chr17:60140431A>G	ENST00000397786.2	-	2	374	c.298T>C	c.(298-300)Tca>Cca	p.S100P		NM_005121.2	NP_005112.2	Q9UHV7	MED13_HUMAN	mediator complex subunit 13	100					androgen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			breast(4)|central_nervous_system(1)|endometrium(10)|kidney(24)|large_intestine(15)|liver(1)|lung(20)|ovary(1)|prostate(3)|skin(2)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	88						CTTTCACCTGATAAGTCATGG	0.383000													8	139					0	0	1	0	0
NLRP13	126204	broad.mit.edu	37	19	56443629	56443629	+	Missense_Mutation	SNP	G	G	A			TCGA-DU-A7T6-01A-11D-A33T-08	TCGA-DU-A7T6-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	675ce5ef-043a-4057-854c-dc78c82c3138	f00ed66c-116a-4665-b75d-7f5d608e7034	g.chr19:56443629G>A	ENST00000588751.1	-	1	73	c.49C>T	c.(49-51)Ctt>Ttt	p.L17F	NLRP13_ENST00000342929.3_Missense_Mutation_p.L17F			Q86W25	NAL13_HUMAN	NLR family, pyrin domain containing 13	17	DAPIN.						ATP binding			NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(13)|lung(58)|ovary(4)|pancreas(2)|prostate(2)|skin(13)|stomach(2)|urinary_tract(1)	109		Colorectal(82;3.48e-05)|Ovarian(87;0.0481)|Renal(1328;0.218)		GBM - Glioblastoma multiforme(193;0.0642)		TAAGGCAGAAGCCCTTGGTTG	0.527000													34	74					0	0	1	0	0
UBFD1	56061	broad.mit.edu	37	16	23569512	23569512	+	Missense_Mutation	SNP	G	G	C			TCGA-DU-A7T6-01A-11D-A33T-08	TCGA-DU-A7T6-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	675ce5ef-043a-4057-854c-dc78c82c3138	f00ed66c-116a-4665-b75d-7f5d608e7034	g.chr16:23569512G>C	ENST00000395878.3	+	2	648	c.267G>C	c.(265-267)aaG>aaC	p.K89N	UBFD1_ENST00000571064.1_3'UTR|UBFD1_ENST00000219638.4_Missense_Mutation_p.K313N|UBFD1_ENST00000567264.1_Missense_Mutation_p.K89N|UBFD1_ENST00000567212.1_Missense_Mutation_p.K80N	NM_019116.2	NP_061989.2	O14562	UBFD1_HUMAN	ubiquitin family domain containing 1	89	Ubiquitin-like.									endometrium(1)|kidney(1)|large_intestine(2)|lung(3)	7				GBM - Glioblastoma multiforme(48;0.0331)		TGGACTTGAAGATCATCTGGA	0.637000													12	71					0	0	1	0	0
ZNF687	57592	broad.mit.edu	37	1	151262420	151262420	+	Silent	SNP	G	G	C			TCGA-DU-A7T6-01A-11D-A33T-08	TCGA-DU-A7T6-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	675ce5ef-043a-4057-854c-dc78c82c3138	f00ed66c-116a-4665-b75d-7f5d608e7034	g.chr1:151262420G>C	ENST00000368879.2	+	6	2999	c.2901G>C	c.(2899-2901)ctG>ctC	p.L967L		NM_020832.1	NP_065883.1	Q8N1G0	ZN687_HUMAN	zinc finger protein 687	967					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus	DNA binding|zinc ion binding			breast(2)|central_nervous_system(3)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(11)|ovary(1)|upper_aerodigestive_tract(2)	32	Lung SC(34;0.00471)|Ovarian(49;0.0147)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)			CCTGTGGCCTGTGTCACTCCT	0.662000													7	12					0	0	1	0	0
ZDHHC17	23390	broad.mit.edu	37	12	77242026	77242026	+	Missense_Mutation	SNP	C	C	G			TCGA-DU-A7T6-01A-11D-A33T-08	TCGA-DU-A7T6-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	675ce5ef-043a-4057-854c-dc78c82c3138	f00ed66c-116a-4665-b75d-7f5d608e7034	g.chr12:77242026C>G	ENST00000426126.2	+	15	2170	c.1521C>G	c.(1519-1521)caC>caG	p.H507Q	ZDHHC17_ENST00000334822.5_Missense_Mutation_p.H507Q|ZDHHC17_ENST00000550789.1_3'UTR	NM_015336.2	NP_056151.2	Q8IUH5	ZDH17_HUMAN	zinc finger, DHHC-type containing 17	507					lipoprotein transport|positive regulation of I-kappaB kinase/NF-kappaB cascade	Golgi-associated vesicle membrane|integral to membrane	magnesium ion transmembrane transporter activity|protein binding|protein-cysteine S-palmitoleyltransferase activity|signal transducer activity|zinc ion binding			breast(2)|endometrium(2)|large_intestine(3)|liver(2)|lung(14)	23						GGGGACTCCACTGTGAGACCA	0.428000													7	52					0	0	1	0	0
GPR112	139378	broad.mit.edu	37	X	135439900	135439900	+	Missense_Mutation	SNP	C	C	T			TCGA-DU-A7T6-01A-11D-A33T-08	TCGA-DU-A7T6-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	675ce5ef-043a-4057-854c-dc78c82c3138	f00ed66c-116a-4665-b75d-7f5d608e7034	g.chrX:135439900C>T	ENST00000394143.1	+	10	7256	c.6965C>T	c.(6964-6966)tCc>tTc	p.S2322F	GPR112_ENST00000287534.4_Intron|GPR112_ENST00000412101.1_Missense_Mutation_p.S2117F|GPR112_ENST00000394141.1_Missense_Mutation_p.S2117F|GPR112_ENST00000370652.1_Missense_Mutation_p.S2322F	NM_153834.3	NP_722576.3	Q8IZF6	GP112_HUMAN	G protein-coupled receptor 112	2322					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(2)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(33)|lung(97)|ovary(5)|pancreas(2)|prostate(4)|skin(10)|upper_aerodigestive_tract(1)|urinary_tract(2)	199	Acute lymphoblastic leukemia(192;0.000127)					GCTACAATTTCCTATGTACCA	0.363000													5	397					0	0	1	0	0
GPRASP1	9737	broad.mit.edu	37	X	101909041	101909041	+	Missense_Mutation	SNP	A	A	G			TCGA-DU-A7T6-01A-11D-A33T-08	TCGA-DU-A7T6-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	675ce5ef-043a-4057-854c-dc78c82c3138	f00ed66c-116a-4665-b75d-7f5d608e7034	g.chrX:101909041A>G	ENST00000537097.1	+	6	1013	c.200A>G	c.(199-201)gAg>gGg	p.E67G	RP4-769N13.7_ENST00000602441.1_RNA|GPRASP1_ENST00000361600.5_Missense_Mutation_p.E67G|GPRASP1_ENST00000444152.1_Missense_Mutation_p.E67G|GPRASP1_ENST00000415986.1_Missense_Mutation_p.E67G	NM_001184727.1	NP_001171656.1	Q5JY77	GASP1_HUMAN	G protein-coupled receptor associated sorting protein 1	67						cytoplasm	protein binding			NS(1)|breast(3)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(10)|lung(29)|ovary(2)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	60						ACCAAAGTTGAGACAAGTGCA	0.542000													8	317					0	0	1	0	0
CLEC18A	348174	broad.mit.edu	37	16	69988452	69988452	+	Silent	SNP	C	C	T			TCGA-DU-A7T6-01A-11D-A33T-08	TCGA-DU-A7T6-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	675ce5ef-043a-4057-854c-dc78c82c3138	f00ed66c-116a-4665-b75d-7f5d608e7034	g.chr16:69988452C>T	ENST00000288040.6	+	3	619	c.432C>T	c.(430-432)aaC>aaT	p.N144N	CLEC18A_ENST00000568461.1_Silent_p.N144N|CLEC18A_ENST00000449317.2_Silent_p.N144N|CLEC18A_ENST00000393701.2_Silent_p.N144N	NM_001136214.1|NM_001271197.1	NP_001129686.1|NP_001258126.1	A5D8T8	CL18A_HUMAN	C-type lectin domain family 18, member A	144	SCP.					extracellular region	sugar binding			NS(1)|endometrium(2)|lung(1)|skin(1)	5						GTGCTCGCAACGCCACCTGCA	0.612000													8	37					0	0	1	0	0
CELSR2	1952	broad.mit.edu	37	1	109792765	109792765	+	Silent	SNP	C	C	T			TCGA-DU-A7T6-01A-11D-A33T-08	TCGA-DU-A7T6-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	675ce5ef-043a-4057-854c-dc78c82c3138	f00ed66c-116a-4665-b75d-7f5d608e7034	g.chr1:109792765C>T	ENST00000271332.3	+	1	125	c.64C>T	c.(64-66)Ctg>Ttg	p.L22L		NM_001408.2	NP_001399.1	Q9HCU4	CELR2_HUMAN	cadherin, EGF LAG seven-pass G-type receptor 2	22					dendrite morphogenesis|homophilic cell adhesion|neural plate anterior/posterior regionalization|neuropeptide signaling pathway|regulation of cell-cell adhesion|regulation of transcription, DNA-dependent|Wnt receptor signaling pathway	cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			NS(1)|autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(14)|lung(27)|ovary(5)|prostate(1)|skin(3)|urinary_tract(2)	82		all_epithelial(167;0.000114)|all_lung(203;0.000321)|Lung NSC(277;0.000626)|Breast(1374;0.244)		Colorectal(144;0.0296)|Lung(183;0.067)|COAD - Colon adenocarcinoma(174;0.114)|Epithelial(280;0.193)|all cancers(265;0.219)		gctgctgttgctgctgctgct	0.746000													3	26					0	0	1	0	0
NPEPPS	9520	broad.mit.edu	37	17	45668227	45668227	+	Missense_Mutation	SNP	G	G	A			TCGA-DU-A7T6-01A-11D-A33T-08	TCGA-DU-A7T6-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	675ce5ef-043a-4057-854c-dc78c82c3138	f00ed66c-116a-4665-b75d-7f5d608e7034	g.chr17:45668227G>A	ENST00000322157.4	+	10	1477	c.1240G>A	c.(1240-1242)Gat>Aat	p.D414N	NPEPPS_ENST00000525037.1_3'UTR|NPEPPS_ENST00000530173.1_Missense_Mutation_p.D410N|NPEPPS_ENST00000544660.1_Missense_Mutation_p.D334N	NM_006310.3	NP_006301.3	P55786	PSA_HUMAN	aminopeptidase puromycin sensitive	414					proteolysis	cytosol|nucleus	aminopeptidase activity|metallopeptidase activity|protein binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(6)|lung(7)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	27						TGACGCCTTAGATAACAGCCA	0.403000													24	233					0	0	1	0	0
KRTAP10-2	386679	broad.mit.edu	37	21	45971301	45971301	+	Missense_Mutation	SNP	G	G	C			TCGA-DU-A7T6-01A-11D-A33T-08	TCGA-DU-A7T6-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	675ce5ef-043a-4057-854c-dc78c82c3138	f00ed66c-116a-4665-b75d-7f5d608e7034	g.chr21:45971301G>C	ENST00000391621.1	-	1	87	c.41C>G	c.(40-42)aCc>aGc	p.T14S	TSPEAR_ENST00000397916.1_Intron|TSPEAR_ENST00000323084.4_Intron|KRTAP10-2_ENST00000498210.1_5'UTR	NM_198693.2	NP_941966.1	P60368	KR102_HUMAN	keratin associated protein 10-2	14						keratin filament				large_intestine(1)|lung(4)|skin(1)	6						CCAGGAGTTGGTGCAGGCGCT	0.667000													19	138					0	0	1	0	0
DMD	1756	broad.mit.edu	37	X	31854865	31854865	+	Nonsense_Mutation	SNP	G	G	C			TCGA-DU-A7T6-01A-11D-A33T-08	TCGA-DU-A7T6-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	675ce5ef-043a-4057-854c-dc78c82c3138	f00ed66c-116a-4665-b75d-7f5d608e7034	g.chrX:31854865G>C	ENST00000357033.4	-	49	7376	c.7170C>G	c.(7168-7170)taC>taG	p.Y2390*	DMD_ENST00000378677.2_Nonsense_Mutation_p.Y2386*|DMD_ENST00000378707.3_5'UTR|DMD_ENST00000541735.1_5'UTR|DMD_ENST00000359836.1_5'UTR|DMD_ENST00000474231.1_5'UTR|DMD_ENST00000343523.2_5'UTR	NM_000109.3|NM_004006.2|NM_004007.2|NM_004011.3|NM_004012.3|NM_004014.2	NP_000100.2|NP_003997.1|NP_003998.1|NP_004002.2|NP_004003.1|NP_004005.1	P11532	DMD_HUMAN	dystrophin	2390					muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			NS(2)|breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(17)|liver(1)|lung(25)|ovary(3)|pancreas(3)|prostate(2)|skin(1)|urinary_tract(2)	77		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				GTTTTTCCTTGTACAAATGCT	0.428000													84	150					0	0	1	0	0
ZNF724P	0	broad.mit.edu	37	19	23406026	23406026	+	Missense_Mutation	SNP	C	C	G			TCGA-DU-A7T6-01A-11D-A33T-08	TCGA-DU-A7T6-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	675ce5ef-043a-4057-854c-dc78c82c3138	f00ed66c-116a-4665-b75d-7f5d608e7034	g.chr19:23406026C>G	ENST00000418100.1	-	4	1138	c.1021G>C	c.(1021-1023)Gaa>Caa	p.E341Q																	endometrium(3)|kidney(1)|lung(2)|ovary(2)	8						CCACATTCTTCACATTTATAA	0.383000													5	29					0	0	1	0	0
ESPNL	339768	broad.mit.edu	37	2	239039021	239039021	+	Missense_Mutation	SNP	C	C	G			TCGA-DU-A7T6-01A-11D-A33T-08	TCGA-DU-A7T6-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	675ce5ef-043a-4057-854c-dc78c82c3138	f00ed66c-116a-4665-b75d-7f5d608e7034	g.chr2:239039021C>G	ENST00000343063.3	+	9	1929	c.1666C>G	c.(1666-1668)Ccc>Gcc	p.P556A	ESPNL_ENST00000409506.1_Missense_Mutation_p.P188A|ESPNL_ENST00000409169.1_Missense_Mutation_p.P512A|ESPNL_ENST00000477241.1_3'UTR	NM_194312.2	NP_919288.2	Q6ZVH7	ESPNL_HUMAN	espin-like	556										endometrium(1)|lung(8)|pancreas(2)|skin(2)	13		Breast(86;7.61e-05)|Renal(207;0.00183)|Ovarian(221;0.0481)|all_hematologic(139;0.158)|all_lung(227;0.198)|Melanoma(123;0.203)|Hepatocellular(293;0.244)		Epithelial(121;4.71e-24)|OV - Ovarian serous cystadenocarcinoma(60;3.02e-12)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;5.63e-08)|BRCA - Breast invasive adenocarcinoma(100;0.000109)|Lung(119;0.0108)|LUSC - Lung squamous cell carcinoma(224;0.0253)		CCACTTCCTGCCCCGGGCGCC	0.701000													9	11					0	0	1	0	0
ZNF823	55552	broad.mit.edu	37	19	11833735	11833735	+	Missense_Mutation	SNP	C	C	G			TCGA-DU-A7T6-01A-11D-A33T-08	TCGA-DU-A7T6-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	675ce5ef-043a-4057-854c-dc78c82c3138	f00ed66c-116a-4665-b75d-7f5d608e7034	g.chr19:11833735C>G	ENST00000341191.6	-	4	767	c.614G>C	c.(613-615)aGt>aCt	p.S205T	ZNF823_ENST00000545749.1_Missense_Mutation_p.S23T	NM_001080493.2	NP_001073962.1	P16415	ZN823_HUMAN	zinc finger protein 823	205					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(4)|kidney(1)|large_intestine(3)|lung(10)|ovary(2)|prostate(1)|upper_aerodigestive_tract(4)	26						ATGAAATAAACTGGGCCAAAC	0.418000										HNSCC(68;0.2)			34	187					0	0	1	0	0
IDH1	3417	broad.mit.edu	37	2	209113112	209113112	+	Missense_Mutation	SNP	C	C	T	rs121913500		TCGA-DU-A7T6-01A-11D-A33T-08	TCGA-DU-A7T6-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	675ce5ef-043a-4057-854c-dc78c82c3138	f00ed66c-116a-4665-b75d-7f5d608e7034	g.chr2:209113112C>T	ENST00000415913.1	-	4	776	c.395G>A	c.(394-396)cGt>cAt	p.R132H	IDH1_ENST00000345146.2_Missense_Mutation_p.R132H|IDH1_ENST00000446179.1_Missense_Mutation_p.R132H			O75874	IDHC_HUMAN	isocitrate dehydrogenase 1 (NADP+), soluble	132			R -> C (in colorectal cancer and glioma samples; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha- ketoglutarate but instead alpha- ketoglutarate is converted to R(-)-2- hydroxyglutarate).|R -> G (in a glioma sample; glioblastoma multiforme; somatic mutation).|R -> H (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> L (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> S (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).		2-oxoglutarate metabolic process|cellular lipid metabolic process|glyoxylate cycle|isocitrate metabolic process|NADPH regeneration|tricarboxylic acid cycle	cytosol|peroxisomal matrix	isocitrate dehydrogenase (NADP+) activity|magnesium ion binding|NAD binding|protein homodimerization activity	p.R132H(2774)|p.R132L(59)|p.R132V(1)|p.G131_R132>VL(1)		NS(1)|autonomic_ganglia(2)|biliary_tract(24)|bone(237)|central_nervous_system(3764)|endometrium(3)|haematopoietic_and_lymphoid_tissue(794)|kidney(2)|large_intestine(7)|lung(7)|prostate(6)|skin(5)|soft_tissue(12)|thyroid(22)|urinary_tract(1)	4887				Epithelial(149;0.0322)|LUSC - Lung squamous cell carcinoma(261;0.0711)|Lung(261;0.136)		ATAAGCATGACGACCTATGAT	0.393000			Mis		gliobastoma								47	72					0	0	1	0	0
FAT1	2195	broad.mit.edu	37	4	187539809	187539809	+	Missense_Mutation	SNP	T	T	C			TCGA-DU-A7T6-01A-11D-A33T-08	TCGA-DU-A7T6-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	675ce5ef-043a-4057-854c-dc78c82c3138	f00ed66c-116a-4665-b75d-7f5d608e7034	g.chr4:187539809T>C	ENST00000441802.2	-	10	8140	c.7931A>G	c.(7930-7932)gAg>gGg	p.E2644G		NM_005245.3	NP_005236.2	Q14517	FAT1_HUMAN	FAT atypical cadherin 1	2644	Cadherin 24.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(38)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(33)|lung(88)|ovary(13)|pancreas(2)|prostate(16)|skin(2)|upper_aerodigestive_tract(11)|urinary_tract(4)	228						TTCCAAATTCTCTTTTACACT	0.423000										HNSCC(5;0.00058)			21	50					0	0	1	0	0
CXorf23	256643	broad.mit.edu	37	X	19953961	19953961	+	Missense_Mutation	SNP	C	C	T			TCGA-DU-A7T6-01A-11D-A33T-08	TCGA-DU-A7T6-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	675ce5ef-043a-4057-854c-dc78c82c3138	f00ed66c-116a-4665-b75d-7f5d608e7034	g.chrX:19953961C>T	ENST00000379687.3	-	9	1862	c.1829G>A	c.(1828-1830)gGa>gAa	p.G610E	CXorf23_ENST00000379682.4_Missense_Mutation_p.G639E|CXorf23_ENST00000356980.3_Intron	NM_198279.3	NP_938020.2	A2AJT9	CX023_HUMAN	chromosome X open reading frame 23	639						mitochondrion				endometrium(2)|large_intestine(1)|lung(6)|skin(1)|urinary_tract(1)	11						TCGGTGGTTTCCCTCAACCTC	0.348000													71	422					0	0	1	0	0
FGD3	89846	broad.mit.edu	37	9	95797674	95797674	+	Missense_Mutation	SNP	G	G	C			TCGA-DU-A7T6-01A-11D-A33T-08	TCGA-DU-A7T6-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	675ce5ef-043a-4057-854c-dc78c82c3138	f00ed66c-116a-4665-b75d-7f5d608e7034	g.chr9:95797674G>C	ENST00000375482.3	+	18	2477	c.1981G>C	c.(1981-1983)Gac>Cac	p.D661H	FGD3_ENST00000337352.6_Missense_Mutation_p.D661H|FGD3_ENST00000416701.2_Missense_Mutation_p.D660H|FGD3_ENST00000538555.1_Missense_Mutation_p.D264H	NM_001083536.1	NP_001077005.1	Q5JSP0	FGD3_HUMAN	FYVE, RhoGEF and PH domain containing 3	661	PH 2.				actin cytoskeleton organization|apoptosis|filopodium assembly|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Cdc42 GTPase activity|regulation of cell shape|small GTPase mediated signal transduction	cytoskeleton|cytosol|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(4)|ovary(2)|prostate(1)|urinary_tract(1)	17						GAGTGTGCCGGACCCTGAGGA	0.677000													4	11					0	0	1	0	0
SEL1L	6400	broad.mit.edu	37	14	81950595	81950595	+	Missense_Mutation	SNP	G	G	A			TCGA-DU-A7T6-01A-11D-A33T-08	TCGA-DU-A7T6-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	675ce5ef-043a-4057-854c-dc78c82c3138	f00ed66c-116a-4665-b75d-7f5d608e7034	g.chr14:81950595G>A	ENST00000336735.4	-	19	2136	c.2020C>T	c.(2020-2022)Cat>Tat	p.H674Y		NM_005065.5	NP_005056.3	Q9UBV2	SE1L1_HUMAN	sel-1 suppressor of lin-12-like (C. elegans)	674	Interaction with ERLEC1, OS9 and SYVN1.				Notch signaling pathway	endoplasmic reticulum membrane|integral to membrane	protein binding			breast(2)|central_nervous_system(1)|endometrium(4)|large_intestine(7)|lung(7)|ovary(1)|pancreas(1)|prostate(2)|urinary_tract(3)	28				BRCA - Breast invasive adenocarcinoma(234;0.0299)		CCTTTCTCATGCATATATCCC	0.393000													6	704					0	0	1	0	0
DIAPH3	81624	broad.mit.edu	37	13	60490363	60490363	+	Missense_Mutation	SNP	G	G	A			TCGA-DU-A7T6-01A-11D-A33T-08	TCGA-DU-A7T6-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	675ce5ef-043a-4057-854c-dc78c82c3138	f00ed66c-116a-4665-b75d-7f5d608e7034	g.chr13:60490363G>A	ENST00000400324.4	-	19	2411	c.2191C>T	c.(2191-2193)Cgg>Tgg	p.R731W	DIAPH3_ENST00000400319.1_Missense_Mutation_p.R661W|DIAPH3_ENST00000400320.1_Missense_Mutation_p.R685W|DIAPH3_ENST00000267215.4_Missense_Mutation_p.R731W|DIAPH3_ENST00000377908.2_Missense_Mutation_p.R720W|DIAPH3_ENST00000400330.1_Missense_Mutation_p.R731W|DIAPH3_ENST00000465066.1_5'UTR	NM_001042517.1|NM_001258366.1	NP_001035982.1|NP_001245295.1	Q9NSV4	DIAP3_HUMAN	diaphanous-related formin 3	731	FH2.				actin cytoskeleton organization		actin binding|Rho GTPase binding			cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(7)|liver(1)|lung(20)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	46		Breast(118;0.052)|Prostate(109;0.103)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;2.77e-05)		TATGGCACCCGAAAAGAGCTC	0.343000													14	80					0	0	1	0	0
IL4R	3566	broad.mit.edu	37	16	27374364	27374364	+	Missense_Mutation	SNP	C	C	A			TCGA-DU-A7T6-01A-11D-A33T-08	TCGA-DU-A7T6-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	675ce5ef-043a-4057-854c-dc78c82c3138	f00ed66c-116a-4665-b75d-7f5d608e7034	g.chr16:27374364C>A	ENST00000395762.2	+	11	1950	c.1691C>A	c.(1690-1692)gCt>gAt	p.A564D	IL4R_ENST00000543915.2_Missense_Mutation_p.A564D|IL4R_ENST00000170630.2_Missense_Mutation_p.A564D|IL4R_ENST00000380922.3_Missense_Mutation_p.A549D	NM_000418.3	NP_000409.1	P24394	IL4RA_HUMAN	interleukin 4 receptor	564	Poly-Ala.|Required for IL4-induced gene expression.				immune response|production of molecular mediator involved in inflammatory response	integral to plasma membrane	identical protein binding|interleukin-4 receptor activity|receptor signaling protein activity			breast(3)|endometrium(2)|kidney(2)|large_intestine(2)|lung(15)|ovary(2)|prostate(2)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)	33						CATGGGGCAGCTGCAGCCCCC	0.657000													17	51					7.07596e-05	7.21291e-05	1	1	0
CKMT2	1160	broad.mit.edu	37	5	80547053	80547053	+	Silent	SNP	G	G	A			TCGA-DU-A7T6-01A-11D-A33T-08	TCGA-DU-A7T6-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	675ce5ef-043a-4057-854c-dc78c82c3138	f00ed66c-116a-4665-b75d-7f5d608e7034	g.chr5:80547053G>A	ENST00000424301.2	+	3	340	c.102G>A	c.(100-102)cgG>cgA	p.R34R	CKMT2_ENST00000505704.1_3'UTR|CKMT2_ENST00000437669.1_Silent_p.R34R|CTC-281B15.1_ENST00000505295.1_RNA|CTC-281B15.1_ENST00000512287.1_RNA|CTC-281B15.1_ENST00000511495.1_RNA|CTC-281B15.1_ENST00000501927.2_RNA|CKMT2_ENST00000254035.4_Silent_p.R34R|CTC-281B15.1_ENST00000503483.2_RNA|CTC-281B15.1_ENST00000502041.2_RNA|CTC-281B15.1_ENST00000500148.2_RNA	NM_001825.2	NP_001816.2	P17540	KCRS_HUMAN	creatine kinase, mitochondrial 2 (sarcomeric)	34					creatine metabolic process|muscle contraction	mitochondrial inner membrane	ATP binding|creatine kinase activity			breast(2)|cervix(1)|endometrium(2)|large_intestine(7)|lung(4)|urinary_tract(1)	17		Lung NSC(167;0.00475)|all_lung(232;0.00502)|Ovarian(174;0.0336)		OV - Ovarian serous cystadenocarcinoma(54;2.29e-44)|Epithelial(54;1.05e-38)|all cancers(79;4.15e-34)	Creatine(DB00148)	TGCTGAACCGGCAGAAAGTGT	0.547000													4	269					0	0	1	0	0
CDH17	1015	broad.mit.edu	37	8	95189844	95189844	+	Missense_Mutation	SNP	T	T	C			TCGA-DU-A7T6-01A-11D-A33T-08	TCGA-DU-A7T6-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	675ce5ef-043a-4057-854c-dc78c82c3138	f00ed66c-116a-4665-b75d-7f5d608e7034	g.chr8:95189844T>C	ENST00000027335.3	-	4	380	c.256A>G	c.(256-258)Agg>Ggg	p.R86G	CDH17_ENST00000450165.2_Missense_Mutation_p.R86G|CDH17_ENST00000441892.2_Missense_Mutation_p.R86G	NM_004063.3	NP_004054.3	Q12864	CAD17_HUMAN	cadherin 17, LI cadherin (liver-intestine)	86	Cadherin 1.					integral to membrane	calcium ion binding			NS(1)|endometrium(5)|kidney(3)|large_intestine(10)|lung(18)|ovary(6)|prostate(3)|skin(4)|stomach(2)	52	Breast(36;4.65e-06)		BRCA - Breast invasive adenocarcinoma(8;0.00691)			CTTGTTTCCCTGTCCAAGGCT	0.463000													53	155					0	0	1	0	0
OR4N5	390437	broad.mit.edu	37	14	20612565	20612565	+	Missense_Mutation	SNP	G	G	A	rs143406902	by1000genomes	TCGA-DU-A7T6-01A-11D-A33T-08	TCGA-DU-A7T6-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	675ce5ef-043a-4057-854c-dc78c82c3138	f00ed66c-116a-4665-b75d-7f5d608e7034	g.chr14:20612565G>A	ENST00000333629.1	+	1	671	c.671G>A	c.(670-672)cGt>cAt	p.R224H		NM_001004724.1	NP_001004724.1	Q8IXE1	OR4N5_HUMAN	olfactory receptor, family 4, subfamily N, member 5	224					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|lung(23)|ovary(1)|skin(2)|urinary_tract(1)	29	all_cancers(95;0.00108)		Epithelial(56;7.58e-07)|all cancers(55;3.84e-06)	GBM - Glioblastoma multiforme(265;0.0143)		ATCCTCTGTCGTATAAGGGAG	0.483000													43	226					0	0	1	0	0
RFX7	64864	broad.mit.edu	37	15	56395801	56395801	+	Missense_Mutation	SNP	C	C	G			TCGA-DU-A7T6-01A-11D-A33T-08	TCGA-DU-A7T6-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	675ce5ef-043a-4057-854c-dc78c82c3138	f00ed66c-116a-4665-b75d-7f5d608e7034	g.chr15:56395801C>G	ENST00000423270.1	-	5	468	c.469G>C	c.(469-471)Gtc>Ctc	p.V157L	RFX7_ENST00000317318.6_Missense_Mutation_p.V157L|RFX7_ENST00000422057.1_Missense_Mutation_p.V60L|RFX7_ENST00000559447.2_Missense_Mutation_p.V60L	NM_022841.5	NP_073752.5	Q2KHR2	RFX7_HUMAN	regulatory factor X, 7	60					regulation of transcription, DNA-dependent	nucleus	DNA binding			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(3)|lung(7)|skin(1)|upper_aerodigestive_tract(1)	19						TTTGGAAAGACGTTTTTCATG	0.393000													7	15					0	0	1	0	0
MBL2	4153	broad.mit.edu	37	10	54530513	54530513	+	Missense_Mutation	SNP	C	C	T			TCGA-DU-A7T6-01A-11D-A33T-08	TCGA-DU-A7T6-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	675ce5ef-043a-4057-854c-dc78c82c3138	f00ed66c-116a-4665-b75d-7f5d608e7034	g.chr10:54530513C>T	ENST00000373968.3	-	2	285	c.221G>A	c.(220-222)gGa>gAa	p.G74E	MBL2_ENST00000493043.1_5'UTR	NM_000242.2	NP_000233.1	P11226	MBL2_HUMAN	mannose-binding lectin (protein C) 2, soluble	74	Collagen-like.				acute-phase response|complement activation, classical pathway|complement activation, lectin pathway|defense response to Gram-positive bacterium|negative regulation of growth of symbiont in host|opsonization|response to oxidative stress	collagen|extracellular space	bacterial cell surface binding|calcium-dependent protein binding|eukaryotic cell surface binding|mannose binding|receptor binding			breast(1)|endometrium(2)|lung(12)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	21						CCCCAACTTTCCAGGGGGGCC	0.522000													54	145					0	0	1	0	0
CRIP2	1397	broad.mit.edu	37	14	105945517	105945517	+	Missense_Mutation	SNP	G	G	C			TCGA-DU-A7T6-01A-11D-A33T-08	TCGA-DU-A7T6-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	675ce5ef-043a-4057-854c-dc78c82c3138	f00ed66c-116a-4665-b75d-7f5d608e7034	g.chr14:105945517G>C	ENST00000329146.4	+	6	1175	c.462G>C	c.(460-462)gaG>gaC	p.E154D	CRIP2_ENST00000548989.1_3'UTR|CRIP2_ENST00000483017.3_Missense_Mutation_p.E228D	NM_001312.2	NP_001303.1	P52943	CRIP2_HUMAN	cysteine-rich protein 2	154	LIM zinc-binding 2.						zinc ion binding			lung(2)	2		Melanoma(154;0.226)	OV - Ovarian serous cystadenocarcinoma(23;0.00897)|Epithelial(46;0.026)	Epithelial(152;0.235)		TGCGCTGCGAGCGCTGCGGGA	0.751000													8	46					0	0	1	0	0
CSF2	1437	broad.mit.edu	37	5	131409573	131409573	+	Silent	SNP	C	C	T			TCGA-DU-A7T6-01A-11D-A33T-08	TCGA-DU-A7T6-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	675ce5ef-043a-4057-854c-dc78c82c3138	f00ed66c-116a-4665-b75d-7f5d608e7034	g.chr5:131409573C>T	ENST00000296871.2	+	1	91	c.57C>T	c.(55-57)ccC>ccT	p.P19P		NM_000758.3	NP_000749.2	P04141	CSF2_HUMAN	colony stimulating factor 2 (granulocyte-macrophage)	19					immune response|negative regulation of cytolysis|positive regulation of DNA replication|positive regulation of interleukin-23 production|positive regulation of macrophage derived foam cell differentiation|positive regulation of podosome assembly|positive regulation of tyrosine phosphorylation of Stat5 protein	extracellular space	cytokine activity|granulocyte macrophage colony-stimulating factor receptor binding|growth factor activity			skin(1)	1		all_cancers(142;4.28e-07)|all_lung(232;2.81e-05)|Lung NSC(810;0.000693)|Lung SC(612;0.122)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)		Sargramostim(DB00020)	TCTCTGCACCCGCCCGCTCGC	0.617000													3	54					0	0	1	0	0
COL4A2	1284	broad.mit.edu	37	13	111109707	111109707	+	Missense_Mutation	SNP	A	A	G			TCGA-DU-A7T6-01A-11D-A33T-08	TCGA-DU-A7T6-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	675ce5ef-043a-4057-854c-dc78c82c3138	f00ed66c-116a-4665-b75d-7f5d608e7034	g.chr13:111109707A>G	ENST00000360467.5	+	21	1663	c.1357A>G	c.(1357-1359)Aaa>Gaa	p.K453E	COL4A2-AS2_ENST00000458403.2_RNA	NM_001846.2	NP_001837.2	P08572	CO4A2_HUMAN	collagen, type IV, alpha 2	453	Triple-helical region.				angiogenesis|axon guidance|extracellular matrix organization|negative regulation of angiogenesis	collagen type IV	extracellular matrix structural constituent|protein binding			NS(1)|central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(4)|liver(2)|lung(48)|ovary(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	80	all_cancers(4;2.21e-12)|all_epithelial(4;2.63e-07)|all_lung(23;5.81e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00323)|all_neural(89;0.0565)|Lung SC(71;0.0753)|Medulloblastoma(90;0.0922)	Breast(118;0.212)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.151)			GTTTGGGCTGAAAGGAGCAAA	0.632000													11	54					0	0	1	0	0
CDH8	1006	broad.mit.edu	37	16	61687749	61687749	+	Silent	SNP	G	G	T			TCGA-DU-A7T6-01A-11D-A33T-08	TCGA-DU-A7T6-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	675ce5ef-043a-4057-854c-dc78c82c3138	f00ed66c-116a-4665-b75d-7f5d608e7034	g.chr16:61687749G>T	ENST00000577390.1	-	12	3117	c.2163C>A	c.(2161-2163)gtC>gtA	p.V721V	CDH8_ENST00000577730.1_Intron|CDH8_ENST00000299345.6_Intron	NM_001796.4	NP_001787.2	P55286	CADH8_HUMAN	cadherin 8, type 2	721					adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding	p.V721V(1)		biliary_tract(1)|breast(3)|cervix(1)|endometrium(7)|kidney(6)|large_intestine(22)|liver(2)|lung(49)|ovary(6)|pancreas(2)|prostate(5)|skin(4)|urinary_tract(4)	112		Ovarian(137;0.0799)|Melanoma(118;0.16)		UCEC - Uterine corpus endometrioid carcinoma (183;0.196)|Epithelial(162;0.0155)|all cancers(182;0.0305)|OV - Ovarian serous cystadenocarcinoma(108;0.0499)|BRCA - Breast invasive adenocarcinoma(181;0.249)		TAAATTCATCGACATCAACAC	0.443000													29	149					1.08312e-15	1.13333e-15	1	1	0
MUC16	94025	broad.mit.edu	37	19	9089401	9089401	+	Missense_Mutation	SNP	C	C	G			TCGA-DU-A7T6-01A-11D-A33T-08	TCGA-DU-A7T6-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	675ce5ef-043a-4057-854c-dc78c82c3138	f00ed66c-116a-4665-b75d-7f5d608e7034	g.chr19:9089401C>G	ENST00000397910.4	-	1	2617	c.2414G>C	c.(2413-2415)aGt>aCt	p.S805T		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	805	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						AGTGAGGACACTCCCTGCTGT	0.512000													93	184					0	0	1	0	0
IL1RAPL1	11141	broad.mit.edu	37	X	29938151	29938151	+	Missense_Mutation	SNP	T	T	C			TCGA-DU-A7T6-01A-11D-A33T-08	TCGA-DU-A7T6-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	675ce5ef-043a-4057-854c-dc78c82c3138	f00ed66c-116a-4665-b75d-7f5d608e7034	g.chrX:29938151T>C	ENST00000378993.1	+	8	1670	c.997T>C	c.(997-999)Tcc>Ccc	p.S333P	IL1RAPL1_ENST00000302196.4_Missense_Mutation_p.S333P	NM_014271.3	NP_055086.1	Q9NZN1	IRPL1_HUMAN	interleukin 1 receptor accessory protein-like 1	333	Ig-like C2-type 3.				innate immune response|negative regulation of calcium ion transport via voltage-gated calcium channel activity|negative regulation of exocytosis|regulation of neuron projection development	cytoplasm|integral to membrane|plasma membrane	protein binding|transmembrane receptor activity			biliary_tract(1)|breast(1)|endometrium(5)|large_intestine(9)|lung(38)|ovary(3)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	62						GGGAAATTACTCCTGTTATGT	0.423000													58	128					0	0	1	0	0
FOLR4	390243	broad.mit.edu	37	11	94038838	94038838	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DU-A7T6-01A-11D-A33T-08	TCGA-DU-A7T6-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	675ce5ef-043a-4057-854c-dc78c82c3138	f00ed66c-116a-4665-b75d-7f5d608e7034	g.chr11:94038838G>A	ENST00000440961.2	+	1	80	c.36G>A	c.(34-36)tgG>tgA	p.W12*		NM_001199206.1	NP_001186135.1	A6ND01	FOLR4_HUMAN	folate receptor 4, delta (putative)	12						extracellular region	folic acid binding|receptor activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(4)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	14						TAGAGCTGTGGACAGTCATGC	0.577000													12	161					0	0	1	0	0
PRDM8	56978	broad.mit.edu	37	4	81121392	81121392	+	Missense_Mutation	SNP	A	A	G			TCGA-DU-A7T6-01A-11D-A33T-08	TCGA-DU-A7T6-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	675ce5ef-043a-4057-854c-dc78c82c3138	f00ed66c-116a-4665-b75d-7f5d608e7034	g.chr4:81121392A>G	ENST00000339711.4	+	8	1389	c.158A>G	c.(157-159)gAc>gGc	p.D53G	PRDM8_ENST00000415738.2_Missense_Mutation_p.D53G|PRDM8_ENST00000504452.1_Missense_Mutation_p.D53G	NM_020226.3	NP_064611.3	Q9NQV8	PRDM8_HUMAN	PR domain containing 8	53	SET.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(2)|skin(2)	10						TCCCTATATGACAGCATAGCT	0.443000													48	183					0	0	1	0	0
WNT9A	7483	broad.mit.edu	37	1	228113078	228113078	+	Missense_Mutation	SNP	C	C	G			TCGA-DU-A7T6-01A-11D-A33T-08	TCGA-DU-A7T6-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	675ce5ef-043a-4057-854c-dc78c82c3138	f00ed66c-116a-4665-b75d-7f5d608e7034	g.chr1:228113078C>G	ENST00000272164.5	-	2	248	c.238G>C	c.(238-240)Gag>Cag	p.E80Q	WNT9A_ENST00000497852.1_5'UTR	NM_003395.2	NP_003386.1	O14904	WNT9A_HUMAN	wingless-type MMTV integration site family, member 9A	80					anterior/posterior pattern formation|axis specification|canonical Wnt receptor signaling pathway|cell-cell signaling|cellular response to retinoic acid|cornea development in camera-type eye|embryonic arm morphogenesis|embryonic skeletal joint morphogenesis|endoderm development|iris morphogenesis|mitotic cell cycle G1/S transition checkpoint|negative regulation of cell proliferation|negative regulation of chondrocyte differentiation|neuron differentiation|positive regulation of smoothened signaling pathway|Wnt receptor signaling pathway, calcium modulating pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	extracellular matrix structural constituent|G-protein-coupled receptor binding|signal transducer activity			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(5)|ovary(2)|pancreas(1)|prostate(2)|skin(1)	19		Prostate(94;0.0405)				ACCAGCGTCTCTGCCACGCCC	0.701000													8	24					0	0	1	0	0
MS4A12	54860	broad.mit.edu	37	11	60274258	60274258	+	Missense_Mutation	SNP	G	G	A	rs147008825	byFrequency	TCGA-DU-A7T6-01A-11D-A33T-08	TCGA-DU-A7T6-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	675ce5ef-043a-4057-854c-dc78c82c3138	f00ed66c-116a-4665-b75d-7f5d608e7034	g.chr11:60274258G>A	ENST00000016913.4	+	6	703	c.646G>A	c.(646-648)Gta>Ata	p.V216I	MS4A12_ENST00000537076.1_Missense_Mutation_p.V170I	NM_017716.2	NP_060186.2	Q9NXJ0	M4A12_HUMAN	membrane-spanning 4-domains, subfamily A, member 12	216						integral to membrane	receptor activity			breast(1)|kidney(3)|large_intestine(2)|lung(9)|prostate(2)	17						GGAGTTCTTCGTAGCTTGTGC	0.423000													33	80					0	0	1	0	0
OR4B1	119765	broad.mit.edu	37	11	48238763	48238763	+	Missense_Mutation	SNP	C	C	G			TCGA-DU-A7T6-01A-11D-A33T-08	TCGA-DU-A7T6-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	675ce5ef-043a-4057-854c-dc78c82c3138	f00ed66c-116a-4665-b75d-7f5d608e7034	g.chr11:48238763C>G	ENST00000309562.2	+	1	420	c.402C>G	c.(400-402)atC>atG	p.I134M		NM_001005470.1	NP_001005470.1	Q8NGF8	OR4B1_HUMAN	olfactory receptor, family 4, subfamily B, member 1	134					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|kidney(1)|large_intestine(3)|lung(14)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	28						TGAACATTATCAGTCGTCAAC	0.463000													32	170					0	0	1	0	0
UQCR10	29796	broad.mit.edu	37	22	30163518	30163518	+	Missense_Mutation	SNP	A	A	G			TCGA-DU-A7T6-01A-11D-A33T-08	TCGA-DU-A7T6-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	675ce5ef-043a-4057-854c-dc78c82c3138	f00ed66c-116a-4665-b75d-7f5d608e7034	g.chr22:30163518A>G	ENST00000330029.6	+	1	161	c.131A>G	c.(130-132)tAc>tGc	p.Y44C	UQCR10_ENST00000401406.3_Missense_Mutation_p.Y44C	NM_001003684.1|NM_013387.3	NP_001003684.1|NP_037519.2	Q9UDW1	QCR9_HUMAN	ubiquinol-cytochrome c reductase, complex III subunit X	44					mitochondrial electron transport, ubiquinol to cytochrome c	mitochondrial inner membrane|respiratory chain	ubiquinol-cytochrome-c reductase activity			breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|ovary(1)	5						GACGCTATCTACGACCACATC	0.607000													11	60					0	0	1	0	0
MPHOSPH9	10198	broad.mit.edu	37	12	123678974	123678974	+	Missense_Mutation	SNP	T	T	C			TCGA-DU-A7T6-01A-11D-A33T-08	TCGA-DU-A7T6-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	675ce5ef-043a-4057-854c-dc78c82c3138	f00ed66c-116a-4665-b75d-7f5d608e7034	g.chr12:123678974T>C	ENST00000606320.1	-	13	2406	c.2200A>G	c.(2200-2202)Aaa>Gaa	p.K734E	MPHOSPH9_ENST00000392425.3_Missense_Mutation_p.K582E|MPHOSPH9_ENST00000302349.5_Missense_Mutation_p.K582E|MPHOSPH9_ENST00000541076.2_Missense_Mutation_p.K704E			Q99550	MPP9_HUMAN	M-phase phosphoprotein 9	582					M phase of mitotic cell cycle	centriole|Golgi membrane				NS(1)|breast(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(18)|prostate(2)|skin(1)	33	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000182)|Epithelial(86;0.00046)|BRCA - Breast invasive adenocarcinoma(302;0.169)		TGAGCTTCTTTATCATCTGAG	0.308000													20	32					0	0	1	0	0
ZNF407	55628	broad.mit.edu	37	18	72775721	72775721	+	Missense_Mutation	SNP	G	G	C			TCGA-DU-A7T6-01A-11D-A33T-08	TCGA-DU-A7T6-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	675ce5ef-043a-4057-854c-dc78c82c3138	f00ed66c-116a-4665-b75d-7f5d608e7034	g.chr18:72775721G>C	ENST00000299687.5	+	8	6044	c.6044G>C	c.(6043-6045)gGc>gCc	p.G2015A		NM_017757.2	NP_060227.2	Q9C0G0	ZN407_HUMAN	zinc finger protein 407	2015					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(6)|kidney(7)|large_intestine(21)|lung(23)|ovary(4)|prostate(3)|upper_aerodigestive_tract(2)	67		Esophageal squamous(42;0.131)|Prostate(75;0.173)		BRCA - Breast invasive adenocarcinoma(31;0.184)		GGCAGGCCCGGCGCCAAAGAC	0.677000													6	31					0	0	1	0	0
ZNF143	7702	broad.mit.edu	37	11	9519288	9519288	+	Missense_Mutation	SNP	A	A	C			TCGA-DU-A7T6-01A-11D-A33T-08	TCGA-DU-A7T6-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	675ce5ef-043a-4057-854c-dc78c82c3138	f00ed66c-116a-4665-b75d-7f5d608e7034	g.chr11:9519288A>C	ENST00000396602.2	+	10	1027	c.908A>C	c.(907-909)aAt>aCt	p.N303T	ZNF143_ENST00000299606.2_Missense_Mutation_p.N275T|ZNF143_ENST00000396597.3_Missense_Mutation_p.N272T|ZNF143_ENST00000396604.1_Missense_Mutation_p.N302T|ZNF143_ENST00000530463.1_Missense_Mutation_p.N302T	NM_003442.5	NP_003433.3	P52747	ZN143_HUMAN	zinc finger protein 143	303					regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase III promoter|transcription from RNA polymerase II promoter|transcription from RNA polymerase III promoter	nucleoplasm	DNA binding|zinc ion binding			endometrium(1)|large_intestine(5)|lung(4)|skin(2)|upper_aerodigestive_tract(1)	13				all cancers(16;4.12e-09)|Epithelial(150;2.29e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0212)		TCGGAAGATAATTGTACTAAA	0.308000													36	81					0	0	1	0	0
CEACAM19	56971	broad.mit.edu	37	19	45176219	45176219	+	Missense_Mutation	SNP	C	C	T			TCGA-DU-A7T6-01A-11D-A33T-08	TCGA-DU-A7T6-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	675ce5ef-043a-4057-854c-dc78c82c3138	f00ed66c-116a-4665-b75d-7f5d608e7034	g.chr19:45176219C>T	ENST00000358777.4	+	2	887	c.407C>T	c.(406-408)aCt>aTt	p.T136I	CEACAM19_ENST00000480278.1_3'UTR|CEACAM19_ENST00000403660.3_Missense_Mutation_p.T136I|CTB-171A8.1_ENST00000590796.1_RNA	NM_001127893.1|NM_020219.3	NP_001121365.1|NP_064604.2	Q7Z692	CEA19_HUMAN	carcinoembryonic antigen-related cell adhesion molecule 19	136						integral to membrane				breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(5)	11	Lung NSC(12;0.00308)|all_lung(12;0.00806)	Prostate(69;0.0376)				AAGGCCAAGACTGAGGTCCAG	0.552000													40	32					0	0	1	0	0
FLT4	2324	broad.mit.edu	37	5	180047675	180047675	+	Silent	SNP	G	G	C			TCGA-DU-A7T6-01A-11D-A33T-08	TCGA-DU-A7T6-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	675ce5ef-043a-4057-854c-dc78c82c3138	f00ed66c-116a-4665-b75d-7f5d608e7034	g.chr5:180047675G>C	ENST00000261937.6	-	16	2418	c.2340C>G	c.(2338-2340)gtC>gtG	p.V780V	FLT4_ENST00000502649.1_Silent_p.V780V|FLT4_ENST00000393347.3_Silent_p.V780V	NM_182925.4	NP_891555.2	P35916	VGFR3_HUMAN	fms-related tyrosine kinase 4	780					positive regulation of cell proliferation	integral to plasma membrane	ATP binding|protein phosphatase binding|vascular endothelial growth factor receptor activity			NS(1)|breast(3)|central_nervous_system(2)|endometrium(1)|kidney(6)|large_intestine(5)|liver(2)|lung(37)|ovary(6)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	71	all_cancers(89;2.21e-05)|all_epithelial(37;5.29e-06)|Renal(175;0.000159)|Lung NSC(126;0.00199)|all_lung(126;0.00351)|Breast(19;0.114)	all_cancers(40;0.00245)|Medulloblastoma(196;0.0133)|all_neural(177;0.0199)|all_hematologic(541;0.163)|Ovarian(839;0.238)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.134)	Sorafenib(DB00398)|Sunitinib(DB01268)	CGCCGGTACCGACAAGGATCA	0.592000													7	60					0	0	1	0	0
CUL9	23113	broad.mit.edu	37	6	43152296	43152296	+	Missense_Mutation	SNP	G	G	A			TCGA-DU-A7T6-01A-11D-A33T-08	TCGA-DU-A7T6-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	675ce5ef-043a-4057-854c-dc78c82c3138	f00ed66c-116a-4665-b75d-7f5d608e7034	g.chr6:43152296G>A	ENST00000252050.4	+	2	332	c.248G>A	c.(247-249)cGg>cAg	p.R83Q	CUL9_ENST00000354495.3_Missense_Mutation_p.R83Q|CUL9_ENST00000372647.2_Missense_Mutation_p.R83Q	NM_015089.2	NP_055904.1	Q8IWT3	CUL9_HUMAN	cullin 9	83					ubiquitin-dependent protein catabolic process	cullin-RING ubiquitin ligase complex|cytoplasm	ATP binding|ubiquitin protein ligase binding|zinc ion binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|liver(1)|lung(30)|ovary(5)|prostate(3)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(4)	92						TTAGGTGAGCGGGCACTATCT	0.572000													33	93					0	0	1	0	0
POLQ	10721	broad.mit.edu	37	3	121151849	121151849	+	Missense_Mutation	SNP	C	C	T			TCGA-DU-A7T6-01A-11D-A33T-08	TCGA-DU-A7T6-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	675ce5ef-043a-4057-854c-dc78c82c3138	f00ed66c-116a-4665-b75d-7f5d608e7034	g.chr3:121151849C>T	ENST00000264233.5	-	29	7703	c.7575G>A	c.(7573-7575)atG>atA	p.M2525I		NM_199420.3	NP_955452.3	O75417	DPOLQ_HUMAN	polymerase (DNA directed), theta	2525					DNA repair|DNA replication	nucleoplasm	ATP binding|ATP-dependent helicase activity|damaged DNA binding|DNA-directed DNA polymerase activity|single-stranded DNA-dependent ATPase activity			NS(2)|breast(7)|central_nervous_system(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(16)|lung(55)|ovary(5)|prostate(3)|skin(4)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(2)	120				GBM - Glioblastoma multiforme(114;0.0915)		TTGGGCAGAACATCCCTTGCA	0.403000								DNA polymerases (catalytic subunits)					6	53					0	0	1	0	0
ZP4	57829	broad.mit.edu	37	1	238049138	238049138	+	Silent	SNP	G	G	A			TCGA-DU-A7T6-01A-11D-A33T-08	TCGA-DU-A7T6-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	675ce5ef-043a-4057-854c-dc78c82c3138	f00ed66c-116a-4665-b75d-7f5d608e7034	g.chr1:238049138G>A	ENST00000366570.4	-	7	1046	c.888C>T	c.(886-888)atC>atT	p.I296I	RP11-193H5.1_ENST00000450451.1_RNA	NM_021186.3	NP_067009.1	Q12836	ZP4_HUMAN	zona pellucida glycoprotein 4	296	ZP.				acrosomal vesicle exocytosis|negative regulation of binding of sperm to zona pellucida|positive regulation of acrosome reaction|positive regulation of humoral immune response|positive regulation of protein kinase activity|positive regulation of T cell proliferation|protein kinase A signaling cascade|protein kinase C signaling cascade	integral to membrane|intracellular|plasma membrane|proteinaceous extracellular matrix	acrosin binding|receptor activity	p.I296I(1)		breast(6)|cervix(2)|endometrium(5)|kidney(2)|large_intestine(8)|lung(42)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	73	Ovarian(103;0.103)	all_cancers(173;0.00175)|all_epithelial(177;0.162)|all_neural(198;0.164)|Melanoma(53;0.211)|Prostate(94;0.214)	OV - Ovarian serous cystadenocarcinoma(106;0.00989)			CCTGGACATTGATTGGGAGAG	0.512000													14	83					0	0	1	0	0
BCR	613	broad.mit.edu	37	22	23613769	23613769	+	Missense_Mutation	SNP	C	C	G			TCGA-DU-A7T6-01A-11D-A33T-08	TCGA-DU-A7T6-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	675ce5ef-043a-4057-854c-dc78c82c3138	f00ed66c-116a-4665-b75d-7f5d608e7034	g.chr22:23613769C>G	ENST00000305877.8	+	6	2662	c.1911C>G	c.(1909-1911)aaC>aaG	p.N637K	BCR_ENST00000359540.3_Missense_Mutation_p.N637K	NM_004327.3	NP_004318.3	P11274	BCR_HUMAN	breakpoint cluster region	637	DH.				regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	ATP binding|GTPase activator activity|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity		BCR/JAK2(6)	central_nervous_system(3)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(9)|ovary(1)|prostate(1)|skin(4)|stomach(1)|urinary_tract(1)	35						CGACCAAGAACTCTCTGGAAA	0.532000			T	"""ABL1,  FGFR1, JAK2 """	"""CML, ALL, AML"""								13	59					0	0	1	0	0
IGF1R	3480	broad.mit.edu	37	15	99500523	99500523	+	Missense_Mutation	SNP	G	G	C			TCGA-DU-A7T6-01A-11D-A33T-08	TCGA-DU-A7T6-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	675ce5ef-043a-4057-854c-dc78c82c3138	f00ed66c-116a-4665-b75d-7f5d608e7034	g.chr15:99500523G>C	ENST00000268035.6	+	21	4567	c.3956G>C	c.(3955-3957)aGa>aCa	p.R1319T	RP11-654A16.3_ENST00000559468.1_RNA|IGF1R_ENST00000558762.1_Missense_Mutation_p.R1318T	NM_000875.3	NP_000866.1	P08069	IGF1R_HUMAN	insulin-like growth factor 1 receptor	1319					anti-apoptosis|immune response|insulin receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of cell migration|positive regulation of cell proliferation|positive regulation of DNA replication|protein autophosphorylation|protein tetramerization	microsome	ATP binding|identical protein binding|insulin binding|insulin receptor binding|insulin receptor substrate binding|insulin-like growth factor I binding|insulin-like growth factor receptor activity|metal ion binding|phosphatidylinositol 3-kinase binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(13)|lung(20)|ovary(1)|prostate(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	63	all_cancers(4;4.17e-14)|all_epithelial(3;4.34e-15)|Lung NSC(78;0.00175)|all_lung(78;0.00351)|Melanoma(26;0.00505)|Medulloblastoma(229;0.163)		Epithelial(2;1.94e-12)|all cancers(5;6.83e-11)|BRCA - Breast invasive adenocarcinoma(2;2.88e-09)|OV - Ovarian serous cystadenocarcinoma(32;0.00261)		Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Mecasermin(DB01277)	CTGCCCGACAGACACTCAGGA	0.687000													6	35					0	0	1	0	0
C5	727	broad.mit.edu	37	9	123742403	123742403	+	Missense_Mutation	SNP	G	G	A			TCGA-DU-A7T6-01A-11D-A33T-08	TCGA-DU-A7T6-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	675ce5ef-043a-4057-854c-dc78c82c3138	f00ed66c-116a-4665-b75d-7f5d608e7034	g.chr9:123742403G>A	ENST00000223642.1	-	28	3645	c.3616C>T	c.(3616-3618)Cgt>Tgt	p.R1206C		NM_001735.2	NP_001726.2	P01031	CO5_HUMAN	complement component 5	1206					activation of MAPK activity|chemotaxis|complement activation, alternative pathway|complement activation, classical pathway|cytolysis|G-protein coupled receptor protein signaling pathway|inflammatory response|negative regulation of macrophage chemotaxis|positive regulation of chemokine secretion|positive regulation vascular endothelial growth factor production	extracellular space|membrane attack complex	chemokine activity|endopeptidase inhibitor activity			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(14)|lung(5)|ovary(2)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	46				OV - Ovarian serous cystadenocarcinoma(323;4.98e-53)|GBM - Glioblastoma multiforme(294;0.0242)	Eculizumab(DB01257)	ACAATTGAACGAAACTGTGGG	0.408000													29	77					0	0	1	0	0
PLEC	5339	broad.mit.edu	37	8	144990713	144990713	+	Missense_Mutation	SNP	G	G	A			TCGA-DU-A7T6-01A-11D-A33T-08	TCGA-DU-A7T6-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	675ce5ef-043a-4057-854c-dc78c82c3138	f00ed66c-116a-4665-b75d-7f5d608e7034	g.chr8:144990713G>A	ENST00000322810.4	-	32	13856	c.13687C>T	c.(13687-13689)Cgt>Tgt	p.R4563C	PLEC_ENST00000527096.1_Missense_Mutation_p.R4449C|PLEC_ENST00000357649.2_Missense_Mutation_p.R4430C|PLEC_ENST00000354589.3_Missense_Mutation_p.R4426C|PLEC_ENST00000356346.3_Missense_Mutation_p.R4412C|PLEC_ENST00000436759.2_Missense_Mutation_p.R4453C|PLEC_ENST00000354958.2_Missense_Mutation_p.R4404C|PLEC_ENST00000398774.2_Missense_Mutation_p.R4394C|PLEC_ENST00000345136.3_Missense_Mutation_p.R4426C	NM_201380.2	NP_958782.1	Q15149	PLEC_HUMAN	plectin	4563	Globular 2.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle			NS(1)|breast(3)|central_nervous_system(4)|cervix(7)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(8)|lung(57)|ovary(4)|pancreas(2)|prostate(11)|skin(9)|stomach(2)|upper_aerodigestive_tract(10)	137						CCCACGTCACGCAGCTTCTGT	0.682000													5	225					0	0	1	0	0
LEFTY2	7044	broad.mit.edu	37	1	226127198	226127198	+	Missense_Mutation	SNP	C	C	G			TCGA-DU-A7T6-01A-11D-A33T-08	TCGA-DU-A7T6-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	675ce5ef-043a-4057-854c-dc78c82c3138	f00ed66c-116a-4665-b75d-7f5d608e7034	g.chr1:226127198C>G	ENST00000366820.5	-	3	948	c.600G>C	c.(598-600)caG>caC	p.Q200H	LEFTY2_ENST00000474493.1_5'UTR|LEFTY2_ENST00000420304.2_Missense_Mutation_p.Q166H	NM_003240.3	NP_003231.2	O00292	LFTY2_HUMAN	left-right determination factor 2	200					cell growth|multicellular organismal development|platelet activation|platelet degranulation|transforming growth factor beta receptor signaling pathway	extracellular space|platelet alpha granule lumen	cytokine activity|growth factor activity|transforming growth factor beta receptor binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(8)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	16	Breast(184;0.197)					GCACCGACACCTGTAGCAGCA	0.716000													7	33					0	0	1	0	0
LILRA1	11024	broad.mit.edu	37	19	55106741	55106741	+	Missense_Mutation	SNP	C	C	T			TCGA-DU-A7T6-01A-11D-A33T-08	TCGA-DU-A7T6-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	675ce5ef-043a-4057-854c-dc78c82c3138	f00ed66c-116a-4665-b75d-7f5d608e7034	g.chr19:55106741C>T	ENST00000453777.1	+	5	705	c.535C>T	c.(535-537)Cgg>Tgg	p.R179W	LILRB1_ENST00000396321.2_Intron|LILRB1_ENST00000418536.2_Intron|LILRA1_ENST00000473156.1_3'UTR|LILRA1_ENST00000251372.3_Missense_Mutation_p.R179W|LILRB1_ENST00000448689.1_Intron	NM_001278318.1	NP_001265247.1	O75019	LIRA1_HUMAN	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1	179	Ig-like C2-type 2.				cell surface receptor linked signaling pathway|defense response|regulation of immune response	integral to membrane|plasma membrane	antigen binding|transmembrane receptor activity			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(5)|liver(1)|lung(23)|ovary(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)	47				GBM - Glioblastoma multiforme(193;0.0348)		TGGGTGGTCCCGGGCCATCTT	0.567000													4	170					0	0	1	0	0
DCX	1641	broad.mit.edu	37	X	110644391	110644391	+	Missense_Mutation	SNP	G	G	A			TCGA-DU-A7T6-01A-11D-A33T-08	TCGA-DU-A7T6-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	675ce5ef-043a-4057-854c-dc78c82c3138	f00ed66c-116a-4665-b75d-7f5d608e7034	g.chrX:110644391G>A	ENST00000338081.3	-	3	946	c.775C>T	c.(775-777)Cgc>Tgc	p.R259C	DCX_ENST00000496551.1_5'UTR|DCX_ENST00000371993.2_Missense_Mutation_p.R178C|DCX_ENST00000356220.3_Missense_Mutation_p.R178C|DCX_ENST00000488120.1_Missense_Mutation_p.R178C|DCX_ENST00000356915.2_Missense_Mutation_p.R178C	NM_000555.3	NP_000546.2	O43602	DCX_HUMAN	doublecortin	259			R -> C (in SBHX).|R -> L (in SBHX).		axon guidance|central nervous system development|intracellular signal transduction	cytosol|microtubule associated complex	microtubule binding	p.R178C(1)|p.R259C(1)		breast(1)|central_nervous_system(2)|endometrium(3)|kidney(1)|large_intestine(10)|lung(17)|skin(6)|upper_aerodigestive_tract(1)	41						AGCTTGGGGCGCACAAAGTCC	0.537000													4	164					0	0	1	0	0
ADAM21P1	0	broad.mit.edu	37	14	70713352	70713352	+	RNA	SNP	C	C	T			TCGA-DU-A7T6-01A-11D-A33T-08	TCGA-DU-A7T6-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	675ce5ef-043a-4057-854c-dc78c82c3138	f00ed66c-116a-4665-b75d-7f5d608e7034	g.chr14:70713352C>T	ENST00000530196.1	-	0	1166					NR_003951.1																						TATGACCTAACTCATGGGCCA	0.418000													104	349					0	0	1	0	0
DNAH9	1770	broad.mit.edu	37	17	11607666	11607666	+	Silent	SNP	C	C	T			TCGA-DU-A7T6-01A-11D-A33T-08	TCGA-DU-A7T6-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	675ce5ef-043a-4057-854c-dc78c82c3138	f00ed66c-116a-4665-b75d-7f5d608e7034	g.chr17:11607666C>T	ENST00000262442.3	+	25	5366	c.5298C>T	c.(5296-5298)ggC>ggT	p.G1766G	DNAH9_ENST00000454412.2_Silent_p.G1766G	NM_001372.3	NP_001363.2	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9	1766	Stem (By similarity).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(2)|autonomic_ganglia(1)|breast(15)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(6)|kidney(17)|large_intestine(49)|liver(2)|lung(123)|ovary(6)|pancreas(1)|prostate(6)|skin(21)|stomach(2)|upper_aerodigestive_tract(13)|urinary_tract(4)	290		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		TGCTGATTGGCCAGCTCTCCA	0.512000													6	115					0	0	1	0	0
IGHMBP2	3508	broad.mit.edu	37	11	68682348	68682348	+	Missense_Mutation	SNP	C	C	G			TCGA-DU-A7T6-01A-11D-A33T-08	TCGA-DU-A7T6-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	675ce5ef-043a-4057-854c-dc78c82c3138	f00ed66c-116a-4665-b75d-7f5d608e7034	g.chr11:68682348C>G	ENST00000255078.3	+	6	880	c.769C>G	c.(769-771)Ctg>Gtg	p.L257V	IGHMBP2_ENST00000539224.1_3'UTR	NM_002180.2	NP_002171.2	P38935	SMBP2_HUMAN	immunoglobulin mu binding protein 2	257	Leu-rich.				cell death|DNA recombination|DNA repair|DNA replication|protein homooligomerization|transcription, DNA-dependent|translation	axon|growth cone|nucleus|ribonucleoprotein complex	ATP binding|ATP-dependent 5'-3' DNA helicase activity|ATP-dependent 5'-3' RNA helicase activity|ribosome binding|single-stranded DNA binding|transcription factor binding|tRNA binding|zinc ion binding			central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(4)|liver(1)|lung(15)|ovary(2)|prostate(2)|soft_tissue(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	36			STAD - Stomach adenocarcinoma(18;0.0208)|LUAD - Lung adenocarcinoma(13;0.0713)			GCGCCTGGCTCTGTGTAAGCA	0.592000													33	162					0	0	1	0	0
PPAPDC1A	196051	broad.mit.edu	37	10	122334784	122334784	+	Missense_Mutation	SNP	G	G	A			TCGA-DU-A7T6-01A-11D-A33T-08	TCGA-DU-A7T6-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	675ce5ef-043a-4057-854c-dc78c82c3138	f00ed66c-116a-4665-b75d-7f5d608e7034	g.chr10:122334784G>A	ENST00000398250.1	+	6	939	c.587G>A	c.(586-588)cGc>cAc	p.R196H	PPAPDC1A_ENST00000439221.1_Missense_Mutation_p.R133H|PPAPDC1A_ENST00000496437.1_3'UTR|PPAPDC1A_ENST00000369073.3_Missense_Mutation_p.R186H|PPAPDC1A_ENST00000541332.1_Missense_Mutation_p.R196H|PPAPDC1A_ENST00000398248.1_Intron	NM_001030059.1	NP_001025230.1	Q5VZY2	PPC1A_HUMAN	phosphatidic acid phosphatase type 2 domain containing 1A	196	Phosphatase sequence motif III.				phospholipid dephosphorylation	integral to membrane	phosphatidate phosphatase activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(12)|ovary(1)|urinary_tract(1)	20		Lung NSC(174;0.1)|all_lung(145;0.132)		all cancers(201;0.0117)		GCCCTGTCCCGCATGTGCGAC	0.607000													4	90					0	0	1	0	0
MUC5B	727897	broad.mit.edu	37	11	1269713	1269713	+	Missense_Mutation	SNP	C	C	G			TCGA-DU-A7T6-01A-11D-A33T-08	TCGA-DU-A7T6-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	675ce5ef-043a-4057-854c-dc78c82c3138	f00ed66c-116a-4665-b75d-7f5d608e7034	g.chr11:1269713C>G	ENST00000447027.1	+	31	11670	c.11612C>G	c.(11611-11613)aCc>aGc	p.T3871S	MUC5B_ENST00000529681.1_Missense_Mutation_p.T3868S|RP11-532E4.2_ENST00000532061.2_RNA			Q9HC84	MUC5B_HUMAN	mucin 5B, oligomeric mucus/gel-forming	3868	11 X approximate tandem repeats, Ser/Thr- rich.|7 X Cys-rich subdomain repeats.|Thr-rich.				cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding			cervix(2)|endometrium(36)|kidney(9)|lung(89)|urinary_tract(1)	137		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		GTGCCGACTACCACAACCACG	0.637000													22	134					0	0	1	0	0
CTSG	1511	broad.mit.edu	37	14	25043978	25043978	+	Missense_Mutation	SNP	C	C	G			TCGA-DU-A7T6-01A-11D-A33T-08	TCGA-DU-A7T6-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	675ce5ef-043a-4057-854c-dc78c82c3138	f00ed66c-116a-4665-b75d-7f5d608e7034	g.chr14:25043978C>G	ENST00000216336.2	-	3	278	c.242G>C	c.(241-243)aGa>aCa	p.R81T		NM_001911.2	NP_001902.1	P08311	CATG_HUMAN	cathepsin G	81	Peptidase S1.				immune response|proteolysis	cell surface|extracellular space|plasma membrane|stored secretory granule	heparin binding|serine-type endopeptidase activity			autonomic_ganglia(1)|breast(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(12)|ovary(2)|skin(1)|urinary_tract(1)	25				GBM - Glioblastoma multiforme(265;0.0269)		GTTTTCCCGTCTCTGGATATT	0.527000													22	126					0	0	1	0	0
LENG8	114823	broad.mit.edu	37	19	54963363	54963363	+	Silent	SNP	G	G	A			TCGA-DU-A7T6-01A-11D-A33T-08	TCGA-DU-A7T6-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	675ce5ef-043a-4057-854c-dc78c82c3138	f00ed66c-116a-4665-b75d-7f5d608e7034	g.chr19:54963363G>A	ENST00000326764.5	+	3	611	c.132G>A	c.(130-132)caG>caA	p.Q44Q	LENG8_ENST00000376514.2_Intron	NM_052925.2	NP_443157.1	Q96PV6	LENG8_HUMAN	leukocyte receptor cluster (LRC) member 8	44							protein binding			breast(1)|central_nervous_system(3)|endometrium(3)|kidney(1)|large_intestine(6)|lung(9)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	30	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.139)		AGGCCCGTCAGGCCCTGGCCA	0.642000													6	57					0	0	1	0	0
SIAH1	6477	broad.mit.edu	37	16	48399314	48399314	+	Silent	SNP	C	C	T			TCGA-DU-A7T6-01A-11D-A33T-08	TCGA-DU-A7T6-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	675ce5ef-043a-4057-854c-dc78c82c3138	f00ed66c-116a-4665-b75d-7f5d608e7034	g.chr16:48399314C>T	ENST00000356721.3	-	1	498	c.75G>A	c.(73-75)agG>agA	p.R25R	SIAH1_ENST00000394725.2_Intron|SIAH1_ENST00000573005.1_5'UTR	NM_001006610.1	NP_001006611.1	Q8IUQ4	SIAH1_HUMAN	siah E3 ubiquitin protein ligase 1	0					axon guidance|cell cycle|neuron apoptosis|proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|spermatogenesis	beta-catenin destruction complex|cytosol|nucleus	protein C-terminus binding|ubiquitin-protein ligase activity|zinc ion binding			endometrium(2)|large_intestine(2)|lung(1)|ovary(1)|stomach(1)	7		all_cancers(37;0.157)|all_lung(18;0.11)|Breast(268;0.238)				TCTTCCTTGTCCTGGCCGCTG	0.498000													5	41					0	0	1	0	0
CCZ1B	221960	broad.mit.edu	37	7	6844658	6844658	+	Silent	SNP	G	G	A			TCGA-DU-A7T6-01A-11D-A33T-08	TCGA-DU-A7T6-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	675ce5ef-043a-4057-854c-dc78c82c3138	f00ed66c-116a-4665-b75d-7f5d608e7034	g.chr7:6844658G>A	ENST00000316731.8	-	12	1589	c.1017C>T	c.(1015-1017)tgC>tgT	p.C339C	CCZ1B_ENST00000538180.1_Silent_p.C196C	NM_198097.3	NP_932765.1	P86790	CCZ1L_HUMAN	CCZ1 vacuolar protein trafficking and biogenesis associated homolog B (S. cerevisiae)	339						lysosomal membrane											CCAGTCTTCGGCAAAAATCCA	0.458000													4	184					0	0	1	0	0
MSH3	4437	broad.mit.edu	37	5	80064755	80064755	+	Missense_Mutation	SNP	A	A	G			TCGA-DU-A7T6-01A-11D-A33T-08	TCGA-DU-A7T6-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	675ce5ef-043a-4057-854c-dc78c82c3138	f00ed66c-116a-4665-b75d-7f5d608e7034	g.chr5:80064755A>G	ENST00000265081.6	+	15	2266	c.2186A>G	c.(2185-2187)cAt>cGt	p.H729R		NM_002439.4	NP_002430.3	P20585	MSH3_HUMAN	mutS homolog 3	729					maintenance of DNA repeat elements|meiotic mismatch repair|negative regulation of DNA recombination|positive regulation of helicase activity|reciprocal meiotic recombination|somatic recombination of immunoglobulin gene segments	MutSbeta complex|nuclear chromosome	ATP binding|DNA-dependent ATPase activity|double-strand/single-strand DNA junction binding|enzyme binding|loop DNA binding|Y-form DNA binding			NS(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(12)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	29		Lung NSC(167;0.00479)|all_lung(232;0.00507)|Ovarian(174;0.0261)|Breast(144;0.244)		OV - Ovarian serous cystadenocarcinoma(54;2.38e-45)|Epithelial(54;1.58e-38)|all cancers(79;4.93e-33)		ATCCGAATGCATTTGCAAGAA	0.328000								Mismatch excision repair (MMR)					16	116					0	0	1	0	0
S1PR4	8698	broad.mit.edu	37	19	3179151	3179151	+	Missense_Mutation	SNP	C	C	T			TCGA-DU-A7T6-01A-11D-A33T-08	TCGA-DU-A7T6-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	675ce5ef-043a-4057-854c-dc78c82c3138	f00ed66c-116a-4665-b75d-7f5d608e7034	g.chr19:3179151C>T	ENST00000246115.3	+	1	416	c.361C>T	c.(361-363)Cgg>Tgg	p.R121W	S1PR4_ENST00000591346.1_Intron	NM_003775.3	NP_003766.1	O95977	S1PR4_HUMAN	sphingosine-1-phosphate receptor 4	121					activation of phospholipase C activity|elevation of cytosolic calcium ion concentration|immune response	integral to plasma membrane	lipid binding|lysosphingolipid and lysophosphatidic acid receptor activity			breast(1)|kidney(2)|lung(5)|ovary(1)|skin(2)|upper_aerodigestive_tract(2)	13						GTGGTTCCTACGGGAGGGCCT	0.701000													24	95					0	0	1	0	0
KIAA1549	57670	broad.mit.edu	37	7	138603381	138603381	+	Missense_Mutation	SNP	G	G	C			TCGA-DU-A7T6-01A-11D-A33T-08	TCGA-DU-A7T6-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	675ce5ef-043a-4057-854c-dc78c82c3138	f00ed66c-116a-4665-b75d-7f5d608e7034	g.chr7:138603381G>C	ENST00000440172.1	-	2	1039	c.991C>G	c.(991-993)Caa>Gaa	p.Q331E	KIAA1549_ENST00000242365.4_Missense_Mutation_p.Q281E|KIAA1549_ENST00000422774.1_Missense_Mutation_p.Q331E	NM_001164665.1|NM_020910.2	NP_001158137.1|NP_065961.2	Q9HCM3	K1549_HUMAN	KIAA1549	331						integral to membrane			KIAA1549/BRAF(703)	large_intestine(4)|pancreas(1)|upper_aerodigestive_tract(2)	7						TCTAGGCTTTGACTCAACACA	0.517000			O	BRAF	pilocytic astrocytoma								32	163					0	0	1	0	0
ADRA2C	152	broad.mit.edu	37	4	3769015	3769015	+	Missense_Mutation	SNP	C	C	G			TCGA-DU-A7T6-01A-11D-A33T-08	TCGA-DU-A7T6-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	675ce5ef-043a-4057-854c-dc78c82c3138	f00ed66c-116a-4665-b75d-7f5d608e7034	g.chr4:3769015C>G	ENST00000330055.5	+	1	891	c.682C>G	c.(682-684)Ctg>Gtg	p.L228V	ADRA2C_ENST00000509482.1_Missense_Mutation_p.L228V	NM_000683.3	NP_000674.2	P18825	ADA2C_HUMAN	adrenoceptor alpha 2C	228					activation of MAPK activity by adrenergic receptor signaling pathway|activation of protein kinase B activity|blood coagulation|cell-cell signaling|energy reserve metabolic process|epidermal growth factor receptor transactivation by G-protein coupled receptor signaling pathway|negative regulation of epinephrine secretion|negative regulation of norepinephrine secretion|positive regulation of neuron differentiation|regulation of insulin secretion	endosome|integral to plasma membrane	alpha-2A adrenergic receptor binding|alpha2-adrenergic receptor activity|epinephrine binding|protein heterodimerization activity|protein homodimerization activity			endometrium(2)|kidney(1)|large_intestine(1)|lung(4)	8				UCEC - Uterine corpus endometrioid carcinoma (64;0.163)	Bethanidine(DB00217)|Brimonidine(DB00484)|Debrisoquin(DB04840)|Fenoldopam(DB00800)|Guanadrel Sulfate(DB00226)|Guanethidine(DB01170)|Lofexidine(DB04948)|Norepinephrine(DB00368)|Yohimbine(DB01392)	CATCATGGGCCTGGTCTACGC	0.697000													3	21					0	0	1	0	0
FOXD1	2297	broad.mit.edu	37	5	72743502	72743502	+	Missense_Mutation	SNP	G	G	C			TCGA-DU-A7T6-01A-11D-A33T-08	TCGA-DU-A7T6-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	675ce5ef-043a-4057-854c-dc78c82c3138	f00ed66c-116a-4665-b75d-7f5d608e7034	g.chr5:72743502G>C	ENST00000499003.3	-	1	850	c.686C>G	c.(685-687)cCc>cGc	p.P229R		NM_004472.2	NP_004463.1	Q16676	FOXD1_HUMAN	forkhead box D1	229					axon extension involved in axon guidance|cartilage development|dichotomous subdivision of terminal units involved in ureteric bud branching|embryo development|enteric nervous system development|iridophore differentiation|lateral line nerve glial cell development|melanocyte differentiation|metanephric capsule specification|negative regulation of transcription, DNA-dependent|neural crest cell migration|peripheral nervous system development|positive regulation of BMP signaling pathway|positive regulation of kidney development|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity|sympathetic nervous system development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			endometrium(1)|kidney(1)|lung(2)	4		Lung NSC(167;0.00327)|Ovarian(174;0.0175)|Prostate(461;0.151)		OV - Ovarian serous cystadenocarcinoma(47;1.07e-54)		cgcggcgttgggtgggagcag	0.761000													6	24					0	0	1	0	0
IL1RL1	9173	broad.mit.edu	37	2	102956584	102956584	+	Missense_Mutation	SNP	C	C	T	rs141061248		TCGA-DU-A7T6-01A-11D-A33T-08	TCGA-DU-A7T6-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	675ce5ef-043a-4057-854c-dc78c82c3138	f00ed66c-116a-4665-b75d-7f5d608e7034	g.chr2:102956584C>T	ENST00000311734.2	+	4	638	c.299C>T	c.(298-300)gCg>gTg	p.A100V	IL1RL1_ENST00000393393.3_Missense_Mutation_p.A100V|IL1RL1_ENST00000409584.1_Missense_Mutation_p.A100V|IL1RL1_ENST00000233954.1_Missense_Mutation_p.A100V|IL1RL1_ENST00000404917.2_5'UTR|IL1RL1_ENST00000473175.1_3'UTR			Q01638	ILRL1_HUMAN	interleukin 1 receptor-like 1	100	Ig-like C2-type 1.				innate immune response	integral to membrane	interleukin-1 receptor activity|receptor signaling protein activity			NS(1)|central_nervous_system(1)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)|skin(3)|urinary_tract(1)	16						ACTGGATATGCGAATGTCACC	0.299000													23	51					0	0	1	0	0
SMARCA1	6594	broad.mit.edu	37	X	128631957	128631957	+	Missense_Mutation	SNP	G	G	C			TCGA-DU-A7T6-01A-11D-A33T-08	TCGA-DU-A7T6-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	675ce5ef-043a-4057-854c-dc78c82c3138	f00ed66c-116a-4665-b75d-7f5d608e7034	g.chrX:128631957G>C	ENST00000371122.4	-	11	1498	c.1369C>G	c.(1369-1371)Cga>Gga	p.R457G	SMARCA1_ENST00000371123.1_Missense_Mutation_p.R457G|SMARCA1_ENST00000371121.3_Missense_Mutation_p.R457G	NM_003069.3	NP_003060.2	P28370	SMCA1_HUMAN	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1	457					ATP-dependent chromatin remodeling|brain development|neuron differentiation|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	NURF complex	ATP binding|DNA binding|helicase activity|nucleosome binding|protein binding			biliary_tract(1)|breast(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|liver(1)|lung(13)|ovary(5)|prostate(1)|skin(1)	45						CAACACTTTCGAAGCTGCATC	0.373000													23	149					0	0	1	0	0
SAMD12	401474	broad.mit.edu	37	8	119452089	119452089	+	Missense_Mutation	SNP	T	T	G			TCGA-DU-A7T6-01A-11D-A33T-08	TCGA-DU-A7T6-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	675ce5ef-043a-4057-854c-dc78c82c3138	f00ed66c-116a-4665-b75d-7f5d608e7034	g.chr8:119452089T>G	ENST00000409003.4	-	3	432	c.304A>C	c.(304-306)Aaa>Caa	p.K102Q	SAMD12_ENST00000314727.4_Missense_Mutation_p.K102Q	NM_001101676.1	NP_001095146.1	Q8N8I0	SAM12_HUMAN	sterile alpha motif domain containing 12	102	SAM.									endometrium(1)|kidney(1)|large_intestine(3)|lung(2)|ovary(2)	9	all_cancers(13;3.91e-25)|Lung NSC(37;1.13e-07)|Ovarian(258;0.0249)		STAD - Stomach adenocarcinoma(47;0.00391)			TCATGCTGTTTGAATGACTCA	0.433000													92	146					0	0	1	0	0
MYO16	23026	broad.mit.edu	37	13	109777629	109777629	+	Silent	SNP	G	G	C			TCGA-DU-A7T6-01A-11D-A33T-08	TCGA-DU-A7T6-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	675ce5ef-043a-4057-854c-dc78c82c3138	f00ed66c-116a-4665-b75d-7f5d608e7034	g.chr13:109777629G>C	ENST00000356711.2	+	30	3765	c.3639G>C	c.(3637-3639)cgG>cgC	p.R1213R	MYO16_ENST00000357550.2_Silent_p.R1213R|MYO16_ENST00000457511.2_Silent_p.R725R	NM_015011.1	NP_055826.1	Q9Y6X6	MYO16_HUMAN	myosin XVI	1213					cerebellum development|negative regulation of cell proliferation|negative regulation of S phase of mitotic cell cycle	myosin complex|nucleoplasm|perinuclear region of cytoplasm|plasma membrane	actin filament binding|ATP binding|motor activity			NS(3)|breast(4)|central_nervous_system(2)|endometrium(10)|kidney(8)|large_intestine(27)|lung(51)|ovary(9)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	121	all_lung(23;0.000332)|all_neural(89;0.00294)|Medulloblastoma(90;0.00596)|Lung NSC(43;0.00751)|Lung SC(71;0.104)		BRCA - Breast invasive adenocarcinoma(86;0.19)|all cancers(43;0.201)			AAAATGACCGGCTCCGTAGTG	0.473000													33	35					0	0	1	0	0
RP1L1	94137	broad.mit.edu	37	8	10480690	10480690	+	Missense_Mutation	SNP	C	C	A			TCGA-DU-A7T6-01A-11D-A33T-08	TCGA-DU-A7T6-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	675ce5ef-043a-4057-854c-dc78c82c3138	f00ed66c-116a-4665-b75d-7f5d608e7034	g.chr8:10480690C>A	ENST00000382483.3	-	2	245	c.22G>T	c.(22-24)Gcc>Tcc	p.A8S	RP1L1_ENST00000329335.3_5'UTR	NM_178857.5	NP_849188.4	A6NKC6	A6NKC6_HUMAN	retinitis pigmentosa 1-like 1	8					intracellular signal transduction					breast(5)|central_nervous_system(2)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(16)|lung(82)|ovary(8)|prostate(5)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(3)	148				COAD - Colon adenocarcinoma(149;0.0811)		GGGGCCTGGGCATTCCTGGGG	0.632000													41	62					4.44401e-20	4.68103e-20	1	1	0
RBBP8NL	140893	broad.mit.edu	37	20	60992299	60992299	+	Missense_Mutation	SNP	G	G	T			TCGA-DU-A7T6-01A-11D-A33T-08	TCGA-DU-A7T6-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	675ce5ef-043a-4057-854c-dc78c82c3138	f00ed66c-116a-4665-b75d-7f5d608e7034	g.chr20:60992299G>T	ENST00000252998.1	-	4	337	c.181C>A	c.(181-183)Ctg>Atg	p.L61M		NM_080833.2	NP_543023.2			RBBP8 N-terminal like																		AGCACCCGCAGGTTCTCCTTC	0.617000													5	12					0.000602214	0.00060605	1	1	0
MTHFD2P1	0	broad.mit.edu	37	3	95374237	95374237	+	RNA	SNP	G	G	A			TCGA-DU-A7T6-01A-11D-A33T-08	TCGA-DU-A7T6-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	675ce5ef-043a-4057-854c-dc78c82c3138	f00ed66c-116a-4665-b75d-7f5d608e7034	g.chr3:95374237G>A	ENST00000494840.1	-	0	1624					NR_077228.1																						ACATTACAATGGGCATTCCAA	0.458000													30	66					0	0	1	0	0
TDGF1	6997	broad.mit.edu	37	3	46620761	46620761	+	Missense_Mutation	SNP	A	A	G			TCGA-DU-A7T6-01A-11D-A33T-08	TCGA-DU-A7T6-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	675ce5ef-043a-4057-854c-dc78c82c3138	f00ed66c-116a-4665-b75d-7f5d608e7034	g.chr3:46620761A>G	ENST00000296145.5	+	3	861	c.128A>G	c.(127-129)tAc>tGc	p.Y43C	LRRC2_ENST00000296144.3_Intron|TDGF1_ENST00000542931.1_Missense_Mutation_p.Y27C	NM_003212.3	NP_003203.1	P13385	TDGF1_HUMAN	teratocarcinoma-derived growth factor 1	43			Y -> D (in dbSNP:rs2293025).		activation of MAPK activity|anterior/posterior axis specification, embryo|mammary gland development|morphogenesis of a branching structure|negative regulation of apoptosis|peptidyl-serine phosphorylation|positive regulation of cell migration|positive regulation of peptidyl-tyrosine phosphorylation	anchored to membrane|cell surface|extrinsic to plasma membrane	growth factor activity			cervix(2)|endometrium(1)|kidney(1)|lung(4)	8				BRCA - Breast invasive adenocarcinoma(193;0.00114)|KIRC - Kidney renal clear cell carcinoma(197;0.0173)|Kidney(197;0.0204)		TCTCGGGGATACCTGGCCTTC	0.517000													36	60					0	0	1	0	0
PLEC	5339	broad.mit.edu	37	8	144997377	144997377	+	Silent	SNP	C	C	G			TCGA-DU-A7T6-01A-11D-A33T-08	TCGA-DU-A7T6-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	675ce5ef-043a-4057-854c-dc78c82c3138	f00ed66c-116a-4665-b75d-7f5d608e7034	g.chr8:144997377C>G	ENST00000322810.4	-	31	7300	c.7131G>C	c.(7129-7131)ctG>ctC	p.L2377L	PLEC_ENST00000527096.1_Silent_p.L2263L|PLEC_ENST00000357649.2_Silent_p.L2244L|PLEC_ENST00000354589.3_Silent_p.L2240L|PLEC_ENST00000356346.3_Silent_p.L2226L|PLEC_ENST00000436759.2_Silent_p.L2267L|PLEC_ENST00000354958.2_Silent_p.L2218L|PLEC_ENST00000398774.2_Silent_p.L2208L|PLEC_ENST00000345136.3_Silent_p.L2240L	NM_201380.2	NP_958782.1	Q15149	PLEC_HUMAN	plectin	2377	Central fibrous rod domain.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle			NS(1)|breast(3)|central_nervous_system(4)|cervix(7)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(8)|lung(57)|ovary(4)|pancreas(2)|prostate(11)|skin(9)|stomach(2)|upper_aerodigestive_tract(10)	137						TGAGCTTGCTCAGCTCCTCCA	0.637000													8	70					0	0	1	0	0
CCND1	595	broad.mit.edu	37	11	69458623	69458623	+	Missense_Mutation	SNP	C	C	G			TCGA-DU-A7T6-01A-11D-A33T-08	TCGA-DU-A7T6-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	675ce5ef-043a-4057-854c-dc78c82c3138	f00ed66c-116a-4665-b75d-7f5d608e7034	g.chr11:69458623C>G	ENST00000227507.2	+	3	665	c.438C>G	c.(436-438)aaC>aaG	p.N146K	CCND1_ENST00000536559.1_Intron	NM_053056.2	NP_444284.1	P24385	CCND1_HUMAN	cyclin D1	146	Cyclin N-terminal.				cell division|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|mitotic cell cycle G1/S transition DNA damage checkpoint|positive regulation of cyclin-dependent protein kinase activity|positive regulation of protein phosphorylation|response to drug|response to UV-A|S phase of mitotic cell cycle	cyclin-dependent protein kinase holoenzyme complex|cytosol|membrane|nucleoplasm	protein kinase binding			NS(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|lung(7)|ovary(1)|urinary_tract(1)	23	all_cancers(3;2.01e-114)|all_epithelial(3;3.59e-122)|Breast(3;5.4e-34)|all_lung(4;1.99e-21)|Lung NSC(4;4.65e-21)|Hepatocellular(3;8.22e-16)|Melanoma(5;1.89e-05)|Ovarian(3;0.0348)		Epithelial(3;7.2e-57)|all cancers(3;7.75e-51)|BRCA - Breast invasive adenocarcinoma(2;4.9e-48)|Lung(3;1.13e-16)|LUSC - Lung squamous cell carcinoma(11;3.74e-15)|STAD - Stomach adenocarcinoma(18;0.0278)|LUAD - Lung adenocarcinoma(13;0.0537)		Arsenic trioxide(DB01169)	TCCTGGTGAACAAGCTCAAGT	0.622000			T	"""IGH@, FSTL3"""	"""CLL, B-ALL, breast"""					Multiple Myeloma(6;0.086)			16	77					0	0	1	0	0
COL5A1	1289	broad.mit.edu	37	9	137708918	137708918	+	Missense_Mutation	SNP	G	G	A			TCGA-DU-A7T6-01A-11D-A33T-08	TCGA-DU-A7T6-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	675ce5ef-043a-4057-854c-dc78c82c3138	f00ed66c-116a-4665-b75d-7f5d608e7034	g.chr9:137708918G>A	ENST00000371817.3	+	53	4583	c.4169G>A	c.(4168-4170)gGa>gAa	p.G1390E		NM_000093.3|NM_001278074.1	NP_000084.3|NP_001265003.1	P20908	CO5A1_HUMAN	collagen, type V, alpha 1	1390	Triple-helical region.				axon guidance|cell adhesion|collagen biosynthetic process|collagen fibril organization|eye morphogenesis|fibril organization|integrin biosynthetic process|skin development|wound healing, spreading of epidermal cells	collagen type V	heparin binding|integrin binding|platelet-derived growth factor binding|proteoglycan binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(26)|liver(2)|lung(36)|ovary(4)|pancreas(4)|prostate(5)|skin(10)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(4)	115		Myeloproliferative disorder(178;0.0341)		all cancers(34;2.28e-08)|OV - Ovarian serous cystadenocarcinoma(145;6.03e-08)|Epithelial(140;6.4e-08)|GBM - Glioblastoma multiforme(294;0.131)		GGGCCTCCAGGAAAAAGGGTA	0.572000													12	45					0	0	1	0	0
UNC13B	10497	broad.mit.edu	37	9	35389883	35389883	+	Missense_Mutation	SNP	G	G	A	rs147799499		TCGA-DU-A7T6-01A-11D-A33T-08	TCGA-DU-A7T6-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	675ce5ef-043a-4057-854c-dc78c82c3138	f00ed66c-116a-4665-b75d-7f5d608e7034	g.chr9:35389883G>A	ENST00000378495.3	+	24	3110	c.2888G>A	c.(2887-2889)cGg>cAg	p.R963Q	UNC13B_ENST00000396787.1_Missense_Mutation_p.R975Q|UNC13B_ENST00000378496.4_Missense_Mutation_p.R963Q	NM_006377.3	NP_006368.3	O14795	UN13B_HUMAN	unc-13 homolog B (C. elegans)	963					excretion|induction of apoptosis|intracellular signal transduction	cell junction|Golgi apparatus|synapse	metal ion binding|receptor activity	p.R963Q(1)		breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(16)|liver(2)|lung(17)|ovary(3)|pancreas(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	63	all_epithelial(49;0.212)		LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00778)|STAD - Stomach adenocarcinoma(86;0.194)			CCCAGCATTCGGAACCTGGAT	0.493000													48	53					0	0	1	0	0
GDF7	151449	broad.mit.edu	37	2	20870684	20870684	+	Missense_Mutation	SNP	C	C	G			TCGA-DU-A7T6-01A-11D-A33T-08	TCGA-DU-A7T6-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	675ce5ef-043a-4057-854c-dc78c82c3138	f00ed66c-116a-4665-b75d-7f5d608e7034	g.chr2:20870684C>G	ENST00000272224.3	+	2	1428	c.852C>G	c.(850-852)atC>atG	p.I284M		NM_182828.2	NP_878248.2	Q7Z4P5	GDF7_HUMAN	growth differentiation factor 7	284					activin receptor signaling pathway|BMP signaling pathway|growth|pathway-restricted SMAD protein phosphorylation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of transcription, DNA-dependent	extracellular space	cytokine activity|growth factor activity			breast(1)|cervix(1)|endometrium(2)|lung(1)|prostate(1)|skin(1)	7	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TCCGGGAGATCCGCGCCCAGG	0.731000													6	9					0	0	1	0	0
SLIT1	6585	broad.mit.edu	37	10	98924616	98924616	+	Missense_Mutation	SNP	G	G	A			TCGA-DU-A7T6-01A-11D-A33T-08	TCGA-DU-A7T6-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	675ce5ef-043a-4057-854c-dc78c82c3138	f00ed66c-116a-4665-b75d-7f5d608e7034	g.chr10:98924616G>A	ENST00000266058.4	-	2	474	c.229C>T	c.(229-231)Cat>Tat	p.H77Y	ARHGAP19-SLIT1_ENST00000453547.2_Silent_p.S502S|SLIT1_ENST00000371041.3_Missense_Mutation_p.H77Y|SLIT1_ENST00000371070.4_Missense_Mutation_p.H77Y|SLIT1_ENST00000456008.2_5'UTR	NM_003061.2	NP_003052.2	O75093	SLIT1_HUMAN	slit homolog 1 (Drosophila)	77					axon extension involved in axon guidance|forebrain morphogenesis|motor axon guidance|negative chemotaxis|negative regulation of synaptogenesis	cytoplasm|extracellular space	calcium ion binding|Roundabout binding			breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(37)|ovary(5)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	78		Colorectal(252;0.162)		Epithelial(162;2.02e-08)|all cancers(201;1.5e-06)		TCATTCTTATGGATCCGAGTG	0.617000													42	80					0	0	1	0	0
VCX2	51480	broad.mit.edu	37	X	8138193	8138193	+	Missense_Mutation	SNP	C	C	G			TCGA-DU-A7T6-01A-11D-A33T-08	TCGA-DU-A7T6-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	675ce5ef-043a-4057-854c-dc78c82c3138	f00ed66c-116a-4665-b75d-7f5d608e7034	g.chrX:8138193C>G	ENST00000317103.4	-	3	606	c.300G>C	c.(298-300)caG>caC	p.Q100H		NM_016378.2	NP_057462.2	Q9H322	VCX2_HUMAN	variable charge, X-linked 2	100										endometrium(1)	1		Colorectal(8;0.0136)|Medulloblastoma(8;0.184)				GGGGGTCGTGCTGGGTCCCCT	0.677000													36	156					0	0	1	0	0
DCAF8L1	139425	broad.mit.edu	37	X	27998066	27998066	+	Silent	SNP	G	G	C			TCGA-DU-A7T6-01A-11D-A33T-08	TCGA-DU-A7T6-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	675ce5ef-043a-4057-854c-dc78c82c3138	f00ed66c-116a-4665-b75d-7f5d608e7034	g.chrX:27998066G>C	ENST00000441525.1	-	1	1500	c.1386C>G	c.(1384-1386)gtC>gtG	p.V462V		NM_001017930.1	NP_001017930.1	A6NGE4	DC8L1_HUMAN	DDB1 and CUL4 associated factor 8-like 1	462										NS(1)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(10)|lung(24)|ovary(3)|prostate(1)|skin(4)|stomach(1)|urinary_tract(1)	56						CCCAGAAGAAGACGTGCCCAC	0.468000													26	66					0	0	1	0	0
ZSCAN16	80345	broad.mit.edu	37	6	28093396	28093396	+	Missense_Mutation	SNP	C	C	T			TCGA-DU-A7T6-01A-11D-A33T-08	TCGA-DU-A7T6-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	675ce5ef-043a-4057-854c-dc78c82c3138	f00ed66c-116a-4665-b75d-7f5d608e7034	g.chr6:28093396C>T	ENST00000340487.4	+	2	324	c.175C>T	c.(175-177)Ctt>Ttt	p.L59F	RP1-265C24.9_ENST00000600652.1_RNA|RP1-265C24.9_ENST00000602810.1_RNA	NM_025231.1	NP_079507.1	Q9H4T2	ZSC16_HUMAN	zinc finger and SCAN domain containing 16	59	SCAN box.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			large_intestine(5)|liver(1)|lung(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	10						CCGTGAAGCTCTTACCCAGCT	0.537000													61	244					0	0	1	0	0
FLNC	2318	broad.mit.edu	37	7	128482936	128482936	+	Missense_Mutation	SNP	C	C	G			TCGA-DU-A7T6-01A-11D-A33T-08	TCGA-DU-A7T6-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	675ce5ef-043a-4057-854c-dc78c82c3138	f00ed66c-116a-4665-b75d-7f5d608e7034	g.chr7:128482936C>G	ENST00000325888.8	+	16	2739	c.2478C>G	c.(2476-2478)aaC>aaG	p.N826K	FLNC_ENST00000346177.6_Missense_Mutation_p.N826K	NM_001458.4	NP_001449.3	Q14315	FLNC_HUMAN	filamin C, gamma	826					cell junction assembly	cytoskeleton|cytosol|plasma membrane|sarcomere	actin binding			biliary_tract(1)|breast(7)|central_nervous_system(1)|cervix(1)|endometrium(19)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(19)|lung(59)|ovary(2)|pancreas(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)	128						AGAATGACAACGACACCTTCA	0.592000													21	70					0	0	1	0	0
ZNF479	90827	broad.mit.edu	37	7	57188424	57188424	+	Missense_Mutation	SNP	A	A	G			TCGA-DU-A7T6-01A-11D-A33T-08	TCGA-DU-A7T6-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	675ce5ef-043a-4057-854c-dc78c82c3138	f00ed66c-116a-4665-b75d-7f5d608e7034	g.chr7:57188424A>G	ENST00000331162.4	-	5	968	c.698T>C	c.(697-699)aTa>aCa	p.I233T		NM_033273.1	NP_150376.1	Q96JC4	ZN479_HUMAN	zinc finger protein 479	233					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(14)|lung(53)|ovary(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	84			GBM - Glioblastoma multiforme(1;9.18e-12)			AGTATGAATTATTTTATGTGT	0.383000													33	32					0	0	1	0	0
PRR23B	389151	broad.mit.edu	37	3	138738956	138738956	+	Missense_Mutation	SNP	C	C	G			TCGA-DU-A7T6-01A-11D-A33T-08	TCGA-DU-A7T6-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	675ce5ef-043a-4057-854c-dc78c82c3138	f00ed66c-116a-4665-b75d-7f5d608e7034	g.chr3:138738956C>G	ENST00000329447.5	-	1	812	c.548G>C	c.(547-549)aGa>aCa	p.R183T	MRPS22_ENST00000495075.1_Intron	NM_001013650.2	NP_001013672.1	Q6ZRT6	PR23B_HUMAN	proline rich 23B	183										NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|large_intestine(3)|lung(16)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29						GAACATACTTCTAGAGGAGGG	0.647000													11	79					0	0	1	0	0
AIFM1	9131	broad.mit.edu	37	X	129290463	129290463	+	Missense_Mutation	SNP	C	C	G			TCGA-DU-A7T6-01A-11D-A33T-08	TCGA-DU-A7T6-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	675ce5ef-043a-4057-854c-dc78c82c3138	f00ed66c-116a-4665-b75d-7f5d608e7034	g.chrX:129290463C>G	ENST00000287295.3	-	2	451	c.221G>C	c.(220-222)gGc>gCc	p.G74A	AIFM1_ENST00000535724.1_Intron|AIFM1_ENST00000346424.2_Intron|AIFM1_ENST00000319908.3_Intron	NM_001130847.3|NM_004208.3	NP_001124319.1|NP_004199.1	O95831	AIFM1_HUMAN	apoptosis-inducing factor, mitochondrion-associated, 1	74					activation of caspase activity|apoptosis in response to endoplasmic reticulum stress|cell redox homeostasis|DNA damage response, signal transduction resulting in induction of apoptosis|DNA fragmentation involved in apoptotic nuclear change	cytosol|mitochondrial inner membrane|mitochondrial intermembrane space|nucleus|perinuclear region of cytoplasm	DNA binding|electron carrier activity|flavin adenine dinucleotide binding|oxidoreductase activity|protein binding			central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(4)|liver(2)|lung(8)|ovary(4)|prostate(2)|urinary_tract(1)	30						TGTTGATAAGCCCACAATAAG	0.443000													42	335					0	0	1	0	0
XKR4	114786	broad.mit.edu	37	8	56015369	56015369	+	Nonsense_Mutation	SNP	C	C	G			TCGA-DU-A7T6-01A-11D-A33T-08	TCGA-DU-A7T6-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	675ce5ef-043a-4057-854c-dc78c82c3138	f00ed66c-116a-4665-b75d-7f5d608e7034	g.chr8:56015369C>G	ENST00000327381.5	+	1	421	c.321C>G	c.(319-321)taC>taG	p.Y107*		NM_052898.1	NP_443130.1	Q5GH76	XKR4_HUMAN	XK, Kell blood group complex subunit-related family, member 4	107						integral to membrane				NS(1)|autonomic_ganglia(1)|endometrium(1)|kidney(3)|large_intestine(4)|liver(2)|lung(12)|ovary(1)|pancreas(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	34			Epithelial(17;0.000117)|all cancers(17;0.000836)			AGCGGCGCTACTCACTGTGGG	0.771000													15	100					0	0	1	0	0
RNF103	7844	broad.mit.edu	37	2	86831619	86831619	+	Missense_Mutation	SNP	G	G	A			TCGA-DU-A7T6-01A-11D-A33T-08	TCGA-DU-A7T6-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	675ce5ef-043a-4057-854c-dc78c82c3138	f00ed66c-116a-4665-b75d-7f5d608e7034	g.chr2:86831619G>A	ENST00000237455.4	-	4	2373	c.1405C>T	c.(1405-1407)Ccg>Tcg	p.P469S	RNF103-CHMP3_ENST00000604011.1_Intron|AC015971.2_ENST00000424788.1_RNA|AC015971.2_ENST00000439077.1_RNA|AC015971.2_ENST00000597638.1_RNA|CHMP3_ENST00000439940.2_Intron|AC015971.2_ENST00000426549.1_RNA	NM_001198951.1|NM_005667.3	NP_001185880.1|NP_005658.1	O00237	RN103_HUMAN	ring finger protein 103	469					central nervous system development|ER-associated protein catabolic process	endoplasmic reticulum membrane|integral to membrane	protein binding|ubiquitin-protein ligase activity|zinc ion binding			central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(7)|lung(7)|skin(2)	25						GAAGCAATCGGGTGGAAGAGG	0.458000													23	105					0	0	1	0	0
PLEC	5339	broad.mit.edu	37	8	144997340	144997340	+	Missense_Mutation	SNP	C	C	G	rs62641756	by1000genomes	TCGA-DU-A7T6-01A-11D-A33T-08	TCGA-DU-A7T6-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	675ce5ef-043a-4057-854c-dc78c82c3138	f00ed66c-116a-4665-b75d-7f5d608e7034	g.chr8:144997340C>G	ENST00000322810.4	-	31	7337	c.7168G>C	c.(7168-7170)Gca>Cca	p.A2390P	PLEC_ENST00000527096.1_Missense_Mutation_p.A2276P|PLEC_ENST00000357649.2_Missense_Mutation_p.A2257P|PLEC_ENST00000354589.3_Missense_Mutation_p.A2253P|PLEC_ENST00000356346.3_Missense_Mutation_p.A2239P|PLEC_ENST00000436759.2_Missense_Mutation_p.A2280P|PLEC_ENST00000354958.2_Missense_Mutation_p.A2231P|PLEC_ENST00000398774.2_Missense_Mutation_p.A2221P|PLEC_ENST00000345136.3_Missense_Mutation_p.A2253P	NM_201380.2	NP_958782.1	Q15149	PLEC_HUMAN	plectin	2390	Central fibrous rod domain.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle			NS(1)|breast(3)|central_nervous_system(4)|cervix(7)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(8)|lung(57)|ovary(4)|pancreas(2)|prostate(11)|skin(9)|stomach(2)|upper_aerodigestive_tract(10)	137						AAGATGAGTGCGCGGTTCTCA	0.642000													9	47					0	0	1	0	0
NME8	51314	broad.mit.edu	37	7	37903019	37903019	+	Missense_Mutation	SNP	G	G	C			TCGA-DU-A7T6-01A-11D-A33T-08	TCGA-DU-A7T6-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	675ce5ef-043a-4057-854c-dc78c82c3138	f00ed66c-116a-4665-b75d-7f5d608e7034	g.chr7:37903019G>C	ENST00000199447.4	+	8	781	c.409G>C	c.(409-411)Gac>Cac	p.D137H	NME8_ENST00000440017.1_Missense_Mutation_p.D137H|EPDR1_ENST00000476620.1_Intron	NM_016616.4	NP_057700.3	Q8N427	TXND3_HUMAN	NME/NM23 family member 8	137					cell differentiation|cell redox homeostasis|CTP biosynthetic process|GTP biosynthetic process|multicellular organismal development|spermatogenesis|UTP biosynthetic process	cytoplasm|microtubule cytoskeleton	ATP binding|nucleoside diphosphate kinase activity										TCCATTAGTAGACTCAGATTC	0.333000													21	197					0	0	1	0	0
HOXA11	3207	broad.mit.edu	37	7	27224559	27224559	+	Missense_Mutation	SNP	G	G	C			TCGA-DU-A7T6-01A-11D-A33T-08	TCGA-DU-A7T6-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	675ce5ef-043a-4057-854c-dc78c82c3138	f00ed66c-116a-4665-b75d-7f5d608e7034	g.chr7:27224559G>C	ENST00000006015.3	-	1	276	c.205C>G	c.(205-207)Ccc>Gcc	p.P69A	HOXA11-AS_ENST00000522863.1_RNA|HOXA11-AS_ENST00000520360.1_RNA	NM_005523.5	NP_005514.1	P31270	HXA11_HUMAN	homeobox A11	69					branching involved in ureteric bud morphogenesis|cartilage development involved in endochondral bone morphogenesis|developmental growth|dorsal/ventral pattern formation|mesodermal cell fate specification|positive regulation of cell development|positive regulation of chondrocyte differentiation	protein-DNA complex|transcription factor complex	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(1)|endometrium(1)|large_intestine(2)|lung(8)|ovary(1)|skin(2)	16						TTAGTGGCGGGCTCAATGGCG	0.657000			T	NUP98	CML						OREG0003747	type=REGULATORY REGION|Gene=BC025338|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	9	97					0	0	1	0	0
SERPINA1	5265	broad.mit.edu	37	14	94849110	94849110	+	Silent	SNP	C	C	T			TCGA-DU-A7T6-01A-11D-A33T-08	TCGA-DU-A7T6-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	675ce5ef-043a-4057-854c-dc78c82c3138	f00ed66c-116a-4665-b75d-7f5d608e7034	g.chr14:94849110C>T	ENST00000448921.1	-	4	1037	c.465G>A	c.(463-465)ttG>ttA	p.L155L	SERPINA1_ENST00000437397.1_Silent_p.L155L|SERPINA1_ENST00000440909.1_Silent_p.L155L|SERPINA1_ENST00000355814.4_Silent_p.L155L|SERPINA1_ENST00000393088.4_Silent_p.L155L|SERPINA1_ENST00000402629.1_Silent_p.L155L|SERPINA1_ENST00000449399.3_Silent_p.L155L|SERPINA1_ENST00000393087.4_Silent_p.L155L|SERPINA1_ENST00000404814.4_Silent_p.L155L	NM_001002236.2|NM_001127701.1|NM_001127703.1|NM_001127704.1|NM_001127705.1	NP_001002236.1|NP_001121173.1|NP_001121175.1|NP_001121176.1|NP_001121177.1	P01009	A1AT_HUMAN	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1	155					acute-phase response|platelet activation|platelet degranulation|regulation of proteolysis	extracellular space|platelet alpha granule lumen|proteinaceous extracellular matrix	protease binding|serine-type endopeptidase inhibitor activity			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(5)|skin(6)|stomach(1)	24		all_cancers(154;0.0649)|all_epithelial(191;0.223)		Epithelial(152;0.135)|COAD - Colon adenocarcinoma(157;0.207)|all cancers(159;0.221)	Alpha-1-proteinase inhibitor(DB00058)	TAACATCCTCCAAAAACTTAT	0.522000													40	92					0	0	1	0	0
RAB35	11021	broad.mit.edu	37	12	120546229	120546229	+	Missense_Mutation	SNP	G	G	C			TCGA-DU-A7T6-01A-11D-A33T-08	TCGA-DU-A7T6-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	675ce5ef-043a-4057-854c-dc78c82c3138	f00ed66c-116a-4665-b75d-7f5d608e7034	g.chr12:120546229G>C	ENST00000229340.5	-	2	283	c.95C>G	c.(94-96)aCt>aGt	p.T32S	RAB35_ENST00000534951.1_Missense_Mutation_p.T32S	NM_001167606.1|NM_006861.6	NP_001161078.1|NP_006852.1	Q15286	RAB35_HUMAN	RAB35, member RAS oncogene family	32					cytokinesis|endosome transport|protein transport|small GTPase mediated signal transduction	cell projection membrane|clathrin-coated endocytic vesicle|coated pit|endosome|intercellular bridge|melanosome	GTP binding|GTPase activity|phosphatidylinositol-4,5-bisphosphate binding			endometrium(1)|ovary(1)	2	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.248)		ACCTGAGAAAGTGTTGTCTGC	0.572000													12	48					0	0	1	0	0
MTMR3	8897	broad.mit.edu	37	22	30421720	30421720	+	Missense_Mutation	SNP	G	G	C			TCGA-DU-A7T6-01A-11D-A33T-08	TCGA-DU-A7T6-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	675ce5ef-043a-4057-854c-dc78c82c3138	f00ed66c-116a-4665-b75d-7f5d608e7034	g.chr22:30421720G>C	ENST00000333027.3	+	20	3771	c.3443G>C	c.(3442-3444)aGc>aCc	p.S1148T	MTMR3_ENST00000406629.1_Missense_Mutation_p.S1148T|MTMR3_ENST00000401950.2_Missense_Mutation_p.S1176T|MTMR3_ENST00000351488.3_Missense_Mutation_p.S1139T|CTA-85E5.10_ENST00000429350.1_RNA|MTMR3_ENST00000323630.5_Missense_Mutation_p.S1040T	NM_153050.2|NM_153051.2	NP_694690.1|NP_694691.1	Q13615	MTMR3_HUMAN	myotubularin related protein 3	1176					phosphatidylinositol dephosphorylation	cytoplasm|membrane|membrane fraction|nucleus	metal ion binding|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity			breast(3)|large_intestine(3)|ovary(2)|skin(8)|upper_aerodigestive_tract(1)	17			OV - Ovarian serous cystadenocarcinoma(5;0.00204)|Epithelial(10;0.06)|all cancers(5;0.107)			TCTTGCTATAGCAGCCTACAT	0.512000													29	125					0	0	1	0	0
RYR3	6263	broad.mit.edu	37	15	33955887	33955887	+	Silent	SNP	G	G	A			TCGA-DU-A7T6-01A-11D-A33T-08	TCGA-DU-A7T6-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	675ce5ef-043a-4057-854c-dc78c82c3138	f00ed66c-116a-4665-b75d-7f5d608e7034	g.chr15:33955887G>A	ENST00000389232.4	+	36	5638	c.5568G>A	c.(5566-5568)gcG>gcA	p.A1856A	RYR3_ENST00000415757.3_Silent_p.A1856A	NM_001036.3	NP_001027.3	Q15413	RYR3_HUMAN	ryanodine receptor 3	1856	4 X approximate repeats.				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(3)|breast(9)|central_nervous_system(8)|cervix(2)|endometrium(29)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(55)|lung(148)|ovary(7)|pancreas(1)|prostate(13)|skin(4)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(3)	311		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		ACATGTCTGCGGCCCTGACTG	0.552000													13	11					0	0	1	0	0
TENM2	57451	broad.mit.edu	37	5	167379648	167379648	+	Missense_Mutation	SNP	C	C	G			TCGA-DU-A7T6-01A-11D-A33T-08	TCGA-DU-A7T6-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	675ce5ef-043a-4057-854c-dc78c82c3138	f00ed66c-116a-4665-b75d-7f5d608e7034	g.chr5:167379648C>G	ENST00000519204.1	+	3	523	c.405C>G	c.(403-405)caC>caG	p.H135Q	TENM2_ENST00000520393.1_3'UTR|TENM2_ENST00000520394.1_Missense_Mutation_p.H65Q|TENM2_ENST00000545108.1_Missense_Mutation_p.H256Q|TENM2_ENST00000403607.2_Missense_Mutation_p.H89Q|TENM2_ENST00000518659.1_Missense_Mutation_p.H256Q|CTC-353G13.1_ENST00000523050.1_RNA					teneurin transmembrane protein 2																		CACCCCCTCACAACCACACGC	0.597000													4	25					0	0	1	0	0
ST3GAL2	6483	broad.mit.edu	37	16	70432112	70432112	+	Missense_Mutation	SNP	C	C	A			TCGA-DU-A7T6-01A-11D-A33T-08	TCGA-DU-A7T6-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	675ce5ef-043a-4057-854c-dc78c82c3138	f00ed66c-116a-4665-b75d-7f5d608e7034	g.chr16:70432112C>A	ENST00000393640.4	-	1	2429	c.322G>T	c.(322-324)Gtc>Ttc	p.V108F	ST3GAL2_ENST00000342907.2_Missense_Mutation_p.V108F|RP11-529K1.4_ENST00000566960.1_RNA			Q16842	SIA4B_HUMAN	ST3 beta-galactoside alpha-2,3-sialyltransferase 2	108					amino sugar metabolic process	extracellular region|Golgi cisterna membrane|integral to Golgi membrane	beta-galactoside alpha-2,3-sialyltransferase activity			breast(1)|endometrium(1)|large_intestine(2)|lung(4)|ovary(2)|prostate(1)	11		Ovarian(137;0.0694)				CACCTCTGGACGTCCGGTGGA	0.592000													6	77					2.7689e-08	2.85938e-08	1	1	0
ROBO2	6092	broad.mit.edu	37	3	77645827	77645827	+	Missense_Mutation	SNP	C	C	G			TCGA-DU-A7T6-01A-11D-A33T-08	TCGA-DU-A7T6-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	675ce5ef-043a-4057-854c-dc78c82c3138	f00ed66c-116a-4665-b75d-7f5d608e7034	g.chr3:77645827C>G	ENST00000461745.1	+	19	3680	c.2780C>G	c.(2779-2781)tCt>tGt	p.S927C	ROBO2_ENST00000487694.3_Missense_Mutation_p.S943C|ROBO2_ENST00000332191.8_Missense_Mutation_p.S927C	NM_002942.4	NP_002933.1	Q9HCK4	ROBO2_HUMAN	roundabout, axon guidance receptor, homolog 2 (Drosophila)	927					apoptosis involved in luteolysis|axon midline choice point recognition|cellular response to hormone stimulus|homophilic cell adhesion|metanephros development|negative regulation of negative chemotaxis|negative regulation of synaptogenesis|olfactory bulb interneuron development|positive regulation of axonogenesis|retinal ganglion cell axon guidance|ureteric bud development	axolemma|cell surface|integral to membrane	axon guidance receptor activity|identical protein binding			NS(1)|biliary_tract(5)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(23)|liver(1)|lung(52)|ovary(2)|pancreas(2)|prostate(5)|skin(8)|upper_aerodigestive_tract(1)	117				Epithelial(33;0.00199)|LUSC - Lung squamous cell carcinoma(21;0.008)|BRCA - Breast invasive adenocarcinoma(55;0.00884)|Lung(72;0.0183)|KIRC - Kidney renal clear cell carcinoma(39;0.0832)|Kidney(39;0.103)		CTTGCTGATTCTTGGCCAGCC	0.438000													30	231					0	0	1	0	0
KIAA1217	56243	broad.mit.edu	37	10	24834864	24834864	+	Missense_Mutation	SNP	C	C	G			TCGA-DU-A7T6-01A-11D-A33T-08	TCGA-DU-A7T6-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	675ce5ef-043a-4057-854c-dc78c82c3138	f00ed66c-116a-4665-b75d-7f5d608e7034	g.chr10:24834864C>G	ENST00000376454.3	+	21	5473	c.5443C>G	c.(5443-5445)Ctg>Gtg	p.L1815V	KIAA1217_ENST00000376451.2_3'UTR|KIAA1217_ENST00000458595.1_Missense_Mutation_p.L1221V|KIAA1217_ENST00000376452.3_Missense_Mutation_p.L1246V|KIAA1217_ENST00000376462.1_Missense_Mutation_p.L1136V|KIAA1217_ENST00000396445.1_3'UTR	NM_019590.3	NP_062536.2	Q5T5P2	SKT_HUMAN	KIAA1217	1815	Ser-rich.				embryonic skeletal system development	cytoplasm				breast(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(19)|lung(19)|ovary(5)|prostate(3)|skin(3)|urinary_tract(1)	70						AAGCAGTTCTCTGCCCTCTTC	0.512000													39	203					0	0	1	0	0
TIGD4	201798	broad.mit.edu	37	4	153691335	153691335	+	Silent	SNP	C	C	T			TCGA-DU-A7T6-01A-11D-A33T-08	TCGA-DU-A7T6-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	675ce5ef-043a-4057-854c-dc78c82c3138	f00ed66c-116a-4665-b75d-7f5d608e7034	g.chr4:153691335C>T	ENST00000304337.2	-	2	1642	c.822G>A	c.(820-822)gaG>gaA	p.E274E		NM_145720.3	NP_663772.1	Q8IY51	TIGD4_HUMAN	tigger transposable element derived 4	274	DDE.				regulation of transcription, DNA-dependent	chromosome, centromeric region|nucleus	chromatin binding|DNA binding			breast(1)|endometrium(2)|large_intestine(9)|lung(9)|ovary(1)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(2)	26	all_hematologic(180;0.093)					CTTGAAATTCCTCATCAAGCT	0.398000													33	197					0	0	1	0	0
CASS4	57091	broad.mit.edu	37	20	55027547	55027547	+	Missense_Mutation	SNP	G	G	A			TCGA-DU-A7T6-01A-11D-A33T-08	TCGA-DU-A7T6-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	675ce5ef-043a-4057-854c-dc78c82c3138	f00ed66c-116a-4665-b75d-7f5d608e7034	g.chr20:55027547G>A	ENST00000371336.3	+	5	1516	c.1315G>A	c.(1315-1317)Gtg>Atg	p.V439M	CASS4_ENST00000360314.3_Missense_Mutation_p.V439M|CASS4_ENST00000434344.1_Intron	NM_001164114.1|NM_020356.3	NP_001157586.1|NP_065089.2	Q9NQ75	CASS4_HUMAN	Cas scaffolding protein family member 4	439					cell adhesion	cytoplasm|cytoskeleton|focal adhesion	two-component sensor activity	p.V439M(1)		breast(1)|endometrium(5)|kidney(1)|large_intestine(7)|lung(26)|ovary(4)|prostate(3)|skin(5)|stomach(1)|urinary_tract(1)	54						GGACCTGGATGTGGCCAAGGA	0.567000													26	23					0	0	1	0	0
MAGEE1	57692	broad.mit.edu	37	X	75651163	75651163	+	Missense_Mutation	SNP	G	G	T			TCGA-DU-A7T6-01A-11D-A33T-08	TCGA-DU-A7T6-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	675ce5ef-043a-4057-854c-dc78c82c3138	f00ed66c-116a-4665-b75d-7f5d608e7034	g.chrX:75651163G>T	ENST00000361470.2	+	1	3118	c.2840G>T	c.(2839-2841)gGg>gTg	p.G947V		NM_020932.2	NP_065983.1	Q9HCI5	MAGE1_HUMAN	melanoma antigen family E, 1	947	Interaction with DTNA (By similarity).					dendrite|nucleus|perinuclear region of cytoplasm|postsynaptic membrane				breast(3)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(12)|lung(20)|ovary(1)|pancreas(1)|skin(3)|urinary_tract(1)	51						GCTGATGTTGGGCACAGGCAA	0.522000													32	45					2.70662e-09	2.81346e-09	1	1	0
NOP58	51602	broad.mit.edu	37	2	203162609	203162610	+	Frame_Shift_Del	DEL	AG	AG	-			TCGA-DU-A7T6-01A-11D-A33T-08	TCGA-DU-A7T6-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	675ce5ef-043a-4057-854c-dc78c82c3138	f00ed66c-116a-4665-b75d-7f5d608e7034	g.chr2:203162609_203162610delAG	ENST00000264279.5	+	12	1474_1475	c.1248_1249delAG	c.(1246-1251)acaafs	p.TE416fs		NM_015934.3	NP_057018.1	Q9Y2X3	NOP58_HUMAN	NOP58 ribonucleoprotein	416					cell growth|rRNA processing|snRNP protein import into nucleus	box C/D snoRNP complex|Cajal body|cytoplasm|pre-snoRNP complex	protein binding|snoRNA binding			breast(2)|cervix(1)|endometrium(3)|large_intestine(4)|lung(4)|prostate(2)	16						TAGCAAAAACAGAAAAATATGA	0.257													10	93	---	---	---	---					
ST3GAL6	10402	broad.mit.edu	37	3	98507067	98507068	+	Splice_Site	INS	-	-	T			TCGA-DU-A7T6-01A-11D-A33T-08	TCGA-DU-A7T6-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	675ce5ef-043a-4057-854c-dc78c82c3138	f00ed66c-116a-4665-b75d-7f5d608e7034	g.chr3:98507067_98507068insT	ENST00000265261.6	+	7	686		c.e7+1		ST3GAL6_ENST00000394162.1_Splice_Site|ST3GAL6_ENST00000462152.1_Splice_Site|ST3GAL6_ENST00000483910.1_Splice_Site	NM_001271147.1	NP_001258076.1	Q9Y274	SIA10_HUMAN	ST3 beta-galactoside alpha-2,3-sialyltransferase 6						amino sugar metabolic process|glycolipid metabolic process|protein glycosylation|protein lipoylation	integral to Golgi membrane	sialyltransferase activity			breast(2)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(7)|ovary(1)	19						TGACAAAATAGTAAGTAGGCAA	0.356													63	89	---	---	---	---					
PPP2R3A	5523	broad.mit.edu	37	3	135721813	135721815	+	In_Frame_Del	DEL	ATT	ATT	-			TCGA-DU-A7T6-01A-11D-A33T-08	TCGA-DU-A7T6-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	675ce5ef-043a-4057-854c-dc78c82c3138	f00ed66c-116a-4665-b75d-7f5d608e7034	g.chr3:135721813_135721815delATT	ENST00000264977.3	+	2	2090_2092	c.1473_1475delATT	c.(1471-1476)aat>aa	p.KF491del	PPP2R3A_ENST00000490467.1_Intron	NM_001190447.1|NM_002718.4	NP_001177376.1|NP_002709.2	Q06190	P2R3A_HUMAN	protein phosphatase 2, regulatory subunit B'', alpha	491					protein dephosphorylation	protein phosphatase type 2A complex	calcium ion binding|protein binding|protein phosphatase type 2A regulator activity			breast(2)|cervix(1)|endometrium(2)|large_intestine(7)|lung(10)|ovary(3)|pancreas(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	31						AAGTTTCTAAATTTGAAGAGGGA	0.335													65	102	---	---	---	---					
RP11-254I22.1	0	broad.mit.edu	37	5	95437716	95437716	+	RNA	DEL	G	G	-			TCGA-DU-A7T6-01A-11D-A33T-08	TCGA-DU-A7T6-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	675ce5ef-043a-4057-854c-dc78c82c3138	f00ed66c-116a-4665-b75d-7f5d608e7034	g.chr5:95437716delG	ENST00000507997.1	+	0	87				CTD-2337A12.1_ENST00000511775.1_RNA|CTD-2337A12.1_ENST00000502645.2_RNA																							ggaagcctgagggggtgtgtt	0.582													2	4	---	---	---	---					
BTN2A3P	0	broad.mit.edu	37	6	26426984	26426984	+	RNA	DEL	T	T	-	rs79308421		TCGA-DU-A7T6-01A-11D-A33T-08	TCGA-DU-A7T6-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	675ce5ef-043a-4057-854c-dc78c82c3138	f00ed66c-116a-4665-b75d-7f5d608e7034	g.chr6:26426984delT	ENST00000466808.2	+	0	1067																											GAACCTAGTCTTTTTTTTTTT	0.428													2	4	---	---	---	---					
DPYS	1807	broad.mit.edu	37	8	105440214	105440214	+	Frame_Shift_Del	DEL	T	T	-			TCGA-DU-A7T6-01A-11D-A33T-08	TCGA-DU-A7T6-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	675ce5ef-043a-4057-854c-dc78c82c3138	f00ed66c-116a-4665-b75d-7f5d608e7034	g.chr8:105440214delT	ENST00000351513.2	-	6	1218	c.1086delA	c.(1084-1086)aafs	p.K362fs		NM_001385.2	NP_001376.1	Q14117	DPYS_HUMAN	dihydropyrimidinase	362					protein homotetramerization|pyrimidine nucleoside catabolic process|thymine catabolic process|uracil catabolic process	cytosol	dihydropyrimidinase activity|zinc ion binding			NS(1)|breast(1)|endometrium(2)|kidney(2)|large_intestine(7)|lung(23)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	41			OV - Ovarian serous cystadenocarcinoma(57;1.61e-06)|STAD - Stomach adenocarcinoma(118;0.229)			CCACCACGCCTTTTTCCCATA	0.478													7	362	---	---	---	---					
C11orf63	79864	broad.mit.edu	37	11	122805551	122805554	+	Frame_Shift_Del	DEL	AAAG	AAAG	-			TCGA-DU-A7T6-01A-11D-A33T-08	TCGA-DU-A7T6-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	675ce5ef-043a-4057-854c-dc78c82c3138	f00ed66c-116a-4665-b75d-7f5d608e7034	g.chr11:122805551_122805554delAAAG	ENST00000227349.2	+	5	1699_1702	c.1402_1405delAAAG	c.(1402-1407)aafs	p.KE468fs	C11orf63_ENST00000531316.1_Frame_Shift_Del_p.KE468fs	NM_024806.2	NP_079082.2	Q6NUN7	CK063_HUMAN	chromosome 11 open reading frame 63	468										breast(1)|central_nervous_system(1)|endometrium(4)|kidney(4)|large_intestine(13)|lung(14)|ovary(3)|pancreas(1)|prostate(2)|skin(1)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(1)	47		Breast(109;0.00249)|Lung NSC(97;0.0177)|all_lung(97;0.018)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;5.34e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0311)		GAATGTTAATAAAGAAAGAGGACA	0.377													32	159	---	---	---	---					
MYO15A	51168	broad.mit.edu	37	17	18055210	18055210	+	Frame_Shift_Del	DEL	C	C	-			TCGA-DU-A7T6-01A-11D-A33T-08	TCGA-DU-A7T6-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	675ce5ef-043a-4057-854c-dc78c82c3138	f00ed66c-116a-4665-b75d-7f5d608e7034	g.chr17:18055210delC	ENST00000205890.5	+	41	8176	c.7838delC	c.(7837-7839)gcfs	p.A2613fs		NM_016239.3	NP_057323.3	Q9UKN7	MYO15_HUMAN	myosin XVA	2613	Tail.				sensory perception of sound	cytoplasm|myosin complex|stereocilium	actin binding|ATP binding|calmodulin binding|motor activity			breast(5)|central_nervous_system(2)|endometrium(17)|kidney(3)|large_intestine(16)|lung(27)|ovary(3)|pancreas(1)|prostate(6)|skin(13)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	99	all_neural(463;0.228)					CATGAGGAGGCCCTGATGATC	0.597													2	4	---	---	---	---					
TANC2	26115	broad.mit.edu	37	17	61483525	61483525	+	Frame_Shift_Del	DEL	T	T	-			TCGA-DU-A7T6-01A-11D-A33T-08	TCGA-DU-A7T6-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	675ce5ef-043a-4057-854c-dc78c82c3138	f00ed66c-116a-4665-b75d-7f5d608e7034	g.chr17:61483525delT	ENST00000424789.2	+	19	3258	c.3254delT	c.(3253-3255)ctfs	p.L1087fs	RP11-269G24.3_ENST00000583552.1_RNA|TANC2_ENST00000389520.4_Frame_Shift_Del_p.L1087fs|AC015923.1_ENST00000431604.1_RNA	NM_025185.3	NP_079461.2	Q9HCD6	TANC2_HUMAN	tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2	1087							binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(15)|ovary(2)|upper_aerodigestive_tract(3)	44						ATTGTTGATCTTTTACTCACC	0.502											OREG0024637	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	36	67	---	---	---	---					
RP11-1055B8.7	0	broad.mit.edu	37	17	79428112	79428116	+	Frame_Shift_Del	DEL	GCACA	GCACA	-			TCGA-DU-A7T6-01A-11D-A33T-08	TCGA-DU-A7T6-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	675ce5ef-043a-4057-854c-dc78c82c3138	f00ed66c-116a-4665-b75d-7f5d608e7034	g.chr17:79428112_79428116delGCACA	ENST00000307745.7	+	30	6423_6427	c.6423_6427delGCACA	c.(6421-6429)gtgcfs	p.VHS2141fs	RP11-1055B8.8_ENST00000572590.1_RNA																							TGTTCCCCGTGCACAGCGTGGCCAC	0.707													12	20	---	---	---	---					
CIC	23152	broad.mit.edu	37	19	42794734	42794735	+	Frame_Shift_Del	DEL	GT	GT	-			TCGA-DU-A7T6-01A-11D-A33T-08	TCGA-DU-A7T6-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	675ce5ef-043a-4057-854c-dc78c82c3138	f00ed66c-116a-4665-b75d-7f5d608e7034	g.chr19:42794734_42794735delGT	ENST00000572681.2	+	11	4609_4610	c.4541_4542delGT	c.(4540-4542)afs	p.S1514fs	CIC_ENST00000575354.2_Frame_Shift_Del_p.S605fs|CIC_ENST00000160740.3_Frame_Shift_Del_p.S605fs			Q96RK0	CIC_HUMAN	capicua transcriptional repressor	605					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding	p.V606fs*83(1)		autonomic_ganglia(1)|breast(5)|central_nervous_system(32)|endometrium(10)|kidney(2)|large_intestine(7)|lung(9)|ovary(7)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	82		Prostate(69;0.00682)				AGACCCGAAAGTGTGGGTGGCC	0.673			"""Mis, F, S"""		oligodendroglioma								65	55	---	---	---	---					
GRIA3	2892	broad.mit.edu	37	X	122551721	122551721	+	Frame_Shift_Del	DEL	T	T	-			TCGA-DU-A7T6-01A-11D-A33T-08	TCGA-DU-A7T6-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	675ce5ef-043a-4057-854c-dc78c82c3138	f00ed66c-116a-4665-b75d-7f5d608e7034	g.chrX:122551721delT	ENST00000541091.1	+	11	1948	c.1921delT	c.(1921-1923)ttfs	p.F642fs	GRIA3_ENST00000542149.1_Intron|GRIA3_ENST00000371251.1_Intron|GRIA3_ENST00000264357.5_Intron|GRIA3_ENST00000371256.5_Intron			P42263	GRIA3_HUMAN	glutamate receptor, ionotropic, AMPA 3	0					glutamate signaling pathway|synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|endocytic vesicle membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity			breast(2)|central_nervous_system(1)|endometrium(8)|kidney(3)|large_intestine(8)|lung(25)|ovary(3)|pancreas(2)|skin(2)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(1)	57					L-Glutamic Acid(DB00142)	CAACTCCAGATTTTTTTCATT	0.358													18	59	---	---	---	---