Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
KTN1	0	broad.mit.edu	37	14	56084854	56084854	+	Splice_Site	SNP	T	T	C			TCGA-DU-A76R-01A-11D-A32B-08	TCGA-DU-A76R-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fd703fa-227d-40f8-962b-53c746b2c372	43476bb5-3d68-4d0c-9e1a-2937705a654b	g.chr14:56084854T>C	ENST00000416613.1	+	3	904		c.e3+2		KTN1_ENST00000395308.1_Splice_Site|KTN1_ENST00000395309.3_Splice_Site|KTN1_ENST00000438792.2_Splice_Site|KTN1_ENST00000395311.1_Splice_Site|KTN1_ENST00000413890.2_Splice_Site|KTN1_ENST00000395314.3_Splice_Site			Q86UP2	KTN1_HUMAN	kinectin 1 (kinesin receptor)						microtubule-based movement	endoplasmic reticulum membrane|integral to plasma membrane|membrane fraction		p.?(1)		breast(4)|central_nervous_system(1)|large_intestine(8)|lung(1)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)	19						CTGACAAAGGTAATATATGGG	0.338000			T	RET	papillary thryoid								14	35					0	0	1	0	0
GRM3	0	broad.mit.edu	37	7	86415889	86415889	+	Nonsense_Mutation	SNP	C	C	T			TCGA-DU-A76R-01A-11D-A32B-08	TCGA-DU-A76R-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fd703fa-227d-40f8-962b-53c746b2c372	43476bb5-3d68-4d0c-9e1a-2937705a654b	g.chr7:86415889C>T	ENST00000361669.2	+	3	1880	c.781C>T	c.(781-783)Cga>Tga	p.R261*	AC005009.2_ENST00000418031.1_RNA|GRM3_ENST00000439827.1_Nonsense_Mutation_p.R261*|GRM3_ENST00000394720.2_Nonsense_Mutation_p.R259*|GRM3_ENST00000546348.1_Intron|AC005009.2_ENST00000452471.1_RNA|GRM3_ENST00000536043.1_Nonsense_Mutation_p.R133*	NM_000840.2	NP_000831.2	Q14832	GRM3_HUMAN	glutamate receptor, metabotropic 3	261					synaptic transmission	integral to plasma membrane				NS(2)|breast(6)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(43)|ovary(3)|pancreas(2)|prostate(4)|skin(25)|upper_aerodigestive_tract(5)	109	Esophageal squamous(14;0.0058)|all_lung(186;0.132)|Lung NSC(181;0.142)				Acamprosate(DB00659)|Nicotine(DB00184)	CAGCGTGATCCGAGAACTGTT	0.652000													9	38					0	0	1	0	0
FOXI1	2299	broad.mit.edu	37	5	169533422	169533422	+	Missense_Mutation	SNP	C	C	T			TCGA-DU-A76R-01A-11D-A32B-08	TCGA-DU-A76R-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fd703fa-227d-40f8-962b-53c746b2c372	43476bb5-3d68-4d0c-9e1a-2937705a654b	g.chr5:169533422C>T	ENST00000449804.2	+	1	506	c.461C>T	c.(460-462)gCc>gTc	p.A154V	FOXI1_ENST00000306268.6_Missense_Mutation_p.A154V	NM_012188.4|NM_144769.2	NP_036320.2|NP_658982.1	Q12951	FOXI1_HUMAN	forkhead box I1	154					epidermal cell fate specification|otic placode formation|pattern specification process|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|transcription regulatory region DNA binding			breast(3)|central_nervous_system(3)|endometrium(1)|kidney(1)|large_intestine(7)|lung(16)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	35	Renal(175;0.000159)|Lung NSC(126;0.0267)|all_lung(126;0.04)	Medulloblastoma(196;0.0109)|all_neural(177;0.0298)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			CAGTACGTGGCCGACAACTTC	0.612000									Pendred syndrome				17	14					0	0	1	0	0
SOX5	6660	broad.mit.edu	37	12	23716299	23716299	+	Missense_Mutation	SNP	G	G	C			TCGA-DU-A76R-01A-11D-A32B-08	TCGA-DU-A76R-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fd703fa-227d-40f8-962b-53c746b2c372	43476bb5-3d68-4d0c-9e1a-2937705a654b	g.chr12:23716299G>C	ENST00000546136.1	-	10	1344	c.1342C>G	c.(1342-1344)Caa>Gaa	p.Q448E	SOX5_ENST00000396007.2_Missense_Mutation_p.Q75E|SOX5_ENST00000451604.2_Missense_Mutation_p.Q461E|SOX5_ENST00000541536.1_Intron|SOX5_ENST00000309359.1_Missense_Mutation_p.Q448E|SOX5_ENST00000537393.1_Missense_Mutation_p.Q426E|SOX5_ENST00000545921.1_Missense_Mutation_p.Q451E|SOX5_ENST00000381381.2_Intron			P35711	SOX5_HUMAN	SRY (sex determining region Y)-box 5	461					transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(25)|ovary(5)|skin(2)|upper_aerodigestive_tract(3)	57						CGAGCTTCTTGGATTGCCTTG	0.448000													26	56					0	0	1	0	0
COMMD5	28991	broad.mit.edu	37	8	146076589	146076589	+	Silent	SNP	C	C	T			TCGA-DU-A76R-01A-11D-A32B-08	TCGA-DU-A76R-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fd703fa-227d-40f8-962b-53c746b2c372	43476bb5-3d68-4d0c-9e1a-2937705a654b	g.chr8:146076589C>T	ENST00000450361.2	-	2	556	c.135G>A	c.(133-135)agG>agA	p.R45R	COMMD5_ENST00000305103.3_Silent_p.R45R|COMMD5_ENST00000402718.3_Silent_p.R45R	NM_001081003.1	NP_001074472.1	Q9GZQ3	COMD5_HUMAN	COMM domain containing 5	45						nucleus	protein binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|ovary(1)|pancreas(1)	11	all_cancers(97;1.14e-11)|all_epithelial(106;7.74e-11)|Lung NSC(106;4.08e-05)|all_lung(105;0.000125)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		Epithelial(56;8.75e-39)|OV - Ovarian serous cystadenocarcinoma(54;1.13e-38)|all cancers(56;8.48e-34)|BRCA - Breast invasive adenocarcinoma(115;0.0355)|Colorectal(110;0.055)			TGAACGTGCTCCTGTCTAGGT	0.607000													32	33					0	0	1	0	0
TRIM72	493829	broad.mit.edu	37	16	31230715	31230715	+	Missense_Mutation	SNP	C	C	T			TCGA-DU-A76R-01A-11D-A32B-08	TCGA-DU-A76R-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fd703fa-227d-40f8-962b-53c746b2c372	43476bb5-3d68-4d0c-9e1a-2937705a654b	g.chr16:31230715C>T	ENST00000322122.3	+	4	876	c.592C>T	c.(592-594)Cgg>Tgg	p.R198W		NM_001008274.3	NP_001008275.2	Q6ZMU5	TRI72_HUMAN	tripartite motif containing 72	198					exocytosis|muscle organ development|muscle system process|plasma membrane repair|protein homooligomerization	cytoplasmic vesicle membrane|sarcolemma	phosphatidylserine binding|zinc ion binding			breast(1)|endometrium(2)|large_intestine(2)|lung(9)|skin(1)	15						AGAGCGTGTACGGGGTGAGGC	0.682000													7	37					0	0	1	0	0
OR13C8	138802	broad.mit.edu	37	9	107332225	107332225	+	Silent	SNP	C	C	T			TCGA-DU-A76R-01A-11D-A32B-08	TCGA-DU-A76R-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fd703fa-227d-40f8-962b-53c746b2c372	43476bb5-3d68-4d0c-9e1a-2937705a654b	g.chr9:107332225C>T	ENST00000335040.1	+	1	777	c.777C>T	c.(775-777)taC>taT	p.Y259Y		NM_001004483.1	NP_001004483.1	Q8NGS7	O13C8_HUMAN	olfactory receptor, family 13, subfamily C, member 8	259					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(2)|kidney(3)|large_intestine(5)|lung(12)|ovary(1)|skin(1)	25						TCTTCATGTACGCAAAGCCTG	0.453000													9	40					0	0	1	0	0
KDM6B	23135	broad.mit.edu	37	17	7750173	7750173	+	Missense_Mutation	SNP	C	C	G			TCGA-DU-A76R-01A-11D-A32B-08	TCGA-DU-A76R-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fd703fa-227d-40f8-962b-53c746b2c372	43476bb5-3d68-4d0c-9e1a-2937705a654b	g.chr17:7750173C>G	ENST00000254846.5	+	9	1137	c.748C>G	c.(748-750)Cca>Gca	p.P250A	KDM6B_ENST00000448097.2_Missense_Mutation_p.P250A	NM_001080424.1	NP_001073893.1	O15054	KDM6B_HUMAN	lysine (K)-specific demethylase 6B	250	Pro-rich.				inflammatory response	nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			central_nervous_system(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(3)|lung(18)|ovary(1)|pancreas(1)|skin(5)	37						gcctccaccaccattaccacc	0.622000													6	8					0	0	1	0	0
SLC2A9	56606	broad.mit.edu	37	4	9998546	9998546	+	Missense_Mutation	SNP	T	T	C			TCGA-DU-A76R-01A-11D-A32B-08	TCGA-DU-A76R-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fd703fa-227d-40f8-962b-53c746b2c372	43476bb5-3d68-4d0c-9e1a-2937705a654b	g.chr4:9998546T>C	ENST00000506583.1	-	5	399	c.182A>G	c.(181-183)aAt>aGt	p.N61S	SLC2A9_ENST00000309065.3_Missense_Mutation_p.N61S|SLC2A9_ENST00000264784.3_Missense_Mutation_p.N90S			Q9NRM0	GTR9_HUMAN	solute carrier family 2 (facilitated glucose transporter), member 9	90					glucose transport|urate metabolic process	integral to membrane|plasma membrane	sugar:hydrogen symporter activity			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(12)|ovary(3)|pancreas(1)|prostate(2)|skin(4)|stomach(1)	35						CCATGACTCATTGTAAAAGGC	0.443000													5	72					0	0	1	0	0
NBPF10	100132406	broad.mit.edu	37	1	145293269	145293269	+	Splice_Site	SNP	G	G	A	rs61350760	by1000genomes	TCGA-DU-A76R-01A-11D-A32B-08	TCGA-DU-A76R-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fd703fa-227d-40f8-962b-53c746b2c372	43476bb5-3d68-4d0c-9e1a-2937705a654b	g.chr1:145293269G>A	ENST00000369338.1	+	1	155		c.e1+1		RP11-458D21.5_ENST00000468030.1_Splice_Site|NBPF10_ENST00000369339.2_Intron			A6NDV3	A6NDV3_HUMAN	neuroblastoma breakpoint family, member 10											NS(3)|breast(1)|central_nervous_system(3)|endometrium(12)|kidney(23)|lung(15)|ovary(1)|prostate(7)|skin(6)|urinary_tract(2)	73	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		TTTCACAACAGTAAGTTAAGA	0.423000													5	33					0	0	1	0	0
SLITRK3	22865	broad.mit.edu	37	3	164907773	164907773	+	Silent	SNP	G	G	T			TCGA-DU-A76R-01A-11D-A32B-08	TCGA-DU-A76R-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fd703fa-227d-40f8-962b-53c746b2c372	43476bb5-3d68-4d0c-9e1a-2937705a654b	g.chr3:164907773G>T	ENST00000475390.1	-	2	1289	c.846C>A	c.(844-846)ccC>ccA	p.P282P	SLITRK3_ENST00000241274.3_Silent_p.P282P			O94933	SLIK3_HUMAN	SLIT and NTRK-like family, member 3	282	LRRCT 1.					integral to membrane				NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(14)|lung(66)|ovary(6)|pancreas(1)|prostate(4)|skin(5)|upper_aerodigestive_tract(5)	119						CAGACAACAAGGGACAGAGTT	0.478000										HNSCC(40;0.11)			13	57					2.27111e-07	2.34321e-07	1	1	0
ARHGAP10	79658	broad.mit.edu	37	4	148985641	148985641	+	Missense_Mutation	SNP	G	G	A			TCGA-DU-A76R-01A-11D-A32B-08	TCGA-DU-A76R-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fd703fa-227d-40f8-962b-53c746b2c372	43476bb5-3d68-4d0c-9e1a-2937705a654b	g.chr4:148985641G>A	ENST00000336498.3	+	22	2494	c.2255G>A	c.(2254-2256)gGa>gAa	p.G752E	ARHGAP10_ENST00000414545.2_Missense_Mutation_p.G350E	NM_024605.3	NP_078881.3	A1A4S6	RHG10_HUMAN	Rho GTPase activating protein 10	752	SH3.				apoptosis|filopodium assembly|regulation of apoptosis|small GTPase mediated signal transduction	cytosol|perinuclear region of cytoplasm|plasma membrane	cytoskeletal adaptor activity|SH3 domain binding			autonomic_ganglia(2)|endometrium(5)|kidney(2)|large_intestine(4)|liver(2)|lung(13)|ovary(1)|pancreas(1)|prostate(1)|skin(2)	33	all_hematologic(180;0.151)	Renal(17;0.0166)		GBM - Glioblastoma multiforme(119;0.0423)		TTTGAAATAGGAGCAATTTTT	0.463000													7	25					0	0	1	0	0
DNAH7	56171	broad.mit.edu	37	2	196728873	196728873	+	Splice_Site	SNP	C	C	T			TCGA-DU-A76R-01A-11D-A32B-08	TCGA-DU-A76R-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fd703fa-227d-40f8-962b-53c746b2c372	43476bb5-3d68-4d0c-9e1a-2937705a654b	g.chr2:196728873C>T	ENST00000312428.6	-	41	7606	c.7506_splice	c.e41+1	p.Q2502_splice		NM_018897.2	NP_061720.2	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	2502	AAA 4 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(4)|breast(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(28)|liver(3)|lung(100)|ovary(4)|prostate(5)|skin(26)|upper_aerodigestive_tract(2)|urinary_tract(3)	205						ATGACAATACCTGAAACCAGT	0.388000													18	23					0	0	1	0	0
CLEC1B	51266	broad.mit.edu	37	12	10145811	10145811	+	Silent	SNP	G	G	A			TCGA-DU-A76R-01A-11D-A32B-08	TCGA-DU-A76R-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fd703fa-227d-40f8-962b-53c746b2c372	43476bb5-3d68-4d0c-9e1a-2937705a654b	g.chr12:10145811G>A	ENST00000428126.2	-	7	791	c.522C>T	c.(520-522)ttC>ttT	p.F174F	CLEC1B_ENST00000298527.6_Silent_p.F207F|CLEC1B_ENST00000348658.4_Silent_p.F174F			Q9P126	CLC1B_HUMAN	C-type lectin domain family 1, member B	207	C-type lectin.				cell surface receptor linked signaling pathway|defense response	integral to plasma membrane	protein binding|sugar binding|transmembrane receptor activity			NS(1)|breast(1)|central_nervous_system(1)|large_intestine(2)|lung(12)|stomach(1)|urinary_tract(1)	19						TGTTCTCACAGAAGGTAGGGT	0.378000													31	105					0	0	1	0	0
TRAF5	7188	broad.mit.edu	37	1	211526628	211526628	+	Missense_Mutation	SNP	G	G	A			TCGA-DU-A76R-01A-11D-A32B-08	TCGA-DU-A76R-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fd703fa-227d-40f8-962b-53c746b2c372	43476bb5-3d68-4d0c-9e1a-2937705a654b	g.chr1:211526628G>A	ENST00000336184.2	+	2	107	c.47G>A	c.(46-48)cGc>cAc	p.R16H	TRAF5_ENST00000462410.1_3'UTR|TRAF5_ENST00000367004.3_Missense_Mutation_p.R16H|TRAF5_ENST00000427925.2_Missense_Mutation_p.R16H|TRAF5_ENST00000261464.5_Missense_Mutation_p.R16H	NM_004619.3	NP_004610.1	O00463	TRAF5_HUMAN	TNF receptor-associated factor 5	16					apoptosis|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|regulation of apoptosis	CD40 receptor complex|centrosome|internal side of plasma membrane	protein binding|ubiquitin-protein ligase activity|zinc ion binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(8)|lung(6)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29				OV - Ovarian serous cystadenocarcinoma(81;0.00946)|all cancers(67;0.0808)|Epithelial(68;0.144)		GGTTTCATCCGCCAGAATTCC	0.483000											OREG0014232	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	18	102					0	0	1	0	0
CCDC68	80323	broad.mit.edu	37	18	52602091	52602091	+	Missense_Mutation	SNP	T	T	C			TCGA-DU-A76R-01A-11D-A32B-08	TCGA-DU-A76R-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fd703fa-227d-40f8-962b-53c746b2c372	43476bb5-3d68-4d0c-9e1a-2937705a654b	g.chr18:52602091T>C	ENST00000591504.1	-	7	834	c.560A>G	c.(559-561)cAa>cGa	p.Q187R	CCDC68_ENST00000337363.4_Missense_Mutation_p.Q187R|CCDC68_ENST00000432185.1_Missense_Mutation_p.Q187R	NM_025214.2	NP_079490.1	Q9H2F9	CCD68_HUMAN	coiled-coil domain containing 68	187										breast(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(5)|skin(3)|stomach(1)	14				Colorectal(16;0.0256)|READ - Rectum adenocarcinoma(59;0.21)		TTCTGTAATTTGACTGTGTTT	0.353000													10	62					0	0	1	0	0
TMEM45B	120224	broad.mit.edu	37	11	129722502	129722502	+	Missense_Mutation	SNP	A	A	C			TCGA-DU-A76R-01A-11D-A32B-08	TCGA-DU-A76R-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fd703fa-227d-40f8-962b-53c746b2c372	43476bb5-3d68-4d0c-9e1a-2937705a654b	g.chr11:129722502A>C	ENST00000281441.3	+	2	213	c.125A>C	c.(124-126)tAt>tCt	p.Y42S	TMEM45B_ENST00000524567.1_Missense_Mutation_p.Y42S	NM_138788.3	NP_620143.1	Q96B21	TM45B_HUMAN	transmembrane protein 45B	42						integral to membrane				endometrium(2)|kidney(1)|large_intestine(2)|lung(5)|skin(1)|stomach(1)	12	all_hematologic(175;0.0537)	Breast(109;0.00526)|Lung NSC(97;0.00901)|all_lung(97;0.018)|Medulloblastoma(222;0.0523)|all_neural(223;0.186)		OV - Ovarian serous cystadenocarcinoma(99;0.012)|Lung(977;0.179)|LUSC - Lung squamous cell carcinoma(976;0.189)		CTACATTACTATCAGCGTCTC	0.498000													5	57					0	0	1	0	0
SAMD9	54809	broad.mit.edu	37	7	92733350	92733350	+	Silent	SNP	G	G	A			TCGA-DU-A76R-01A-11D-A32B-08	TCGA-DU-A76R-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fd703fa-227d-40f8-962b-53c746b2c372	43476bb5-3d68-4d0c-9e1a-2937705a654b	g.chr7:92733350G>A	ENST00000379958.2	-	3	2330	c.2061C>T	c.(2059-2061)ggC>ggT	p.G687G		NM_001193307.1|NM_017654.3	NP_001180236.1|NP_060124.2	Q5K651	SAMD9_HUMAN	sterile alpha motif domain containing 9	687						cytoplasm				NS(1)|breast(4)|central_nervous_system(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(20)|lung(32)|ovary(4)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	88	all_cancers(62;5.71e-11)|all_epithelial(64;3.25e-10)|Breast(17;0.000675)|Lung NSC(181;0.0969)|all_lung(186;0.125)		STAD - Stomach adenocarcinoma(171;0.000302)			ATGACACTTTGCCACCTCGAT	0.353000													26	125					0	0	1	0	0
ASB5	140458	broad.mit.edu	37	4	177142621	177142621	+	Missense_Mutation	SNP	G	G	A			TCGA-DU-A76R-01A-11D-A32B-08	TCGA-DU-A76R-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fd703fa-227d-40f8-962b-53c746b2c372	43476bb5-3d68-4d0c-9e1a-2937705a654b	g.chr4:177142621G>A	ENST00000296525.3	-	4	628	c.515C>T	c.(514-516)aCg>aTg	p.T172M	ASB5_ENST00000512254.1_Missense_Mutation_p.T119M	NM_080874.3	NP_543150.1	Q8WWX0	ASB5_HUMAN	ankyrin repeat and SOCS box containing 5	172					intracellular signal transduction			p.T172M(1)		endometrium(2)|kidney(1)|large_intestine(9)|lung(18)|prostate(2)|skin(2)	34		Breast(14;0.00015)|Melanoma(52;0.00886)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;2.13e-20)|Epithelial(43;9.94e-18)|OV - Ovarian serous cystadenocarcinoma(60;2e-09)|GBM - Glioblastoma multiforme(59;0.000254)|STAD - Stomach adenocarcinoma(60;0.000653)|LUSC - Lung squamous cell carcinoma(193;0.0393)		GGCCTCATGCGTTGGGGATGG	0.493000													8	71					0	0	1	0	0
NISCH	11188	broad.mit.edu	37	3	52525392	52525392	+	Missense_Mutation	SNP	C	C	T			TCGA-DU-A76R-01A-11D-A32B-08	TCGA-DU-A76R-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fd703fa-227d-40f8-962b-53c746b2c372	43476bb5-3d68-4d0c-9e1a-2937705a654b	g.chr3:52525392C>T	ENST00000345716.4	+	20	3901	c.3767C>T	c.(3766-3768)aCg>aTg	p.T1256M	NISCH_ENST00000479054.1_Missense_Mutation_p.T1256M	NM_007184.3	NP_009115.2	Q9Y2I1	NISCH_HUMAN	nischarin	1256					apoptosis|cell communication	cytosol|early endosome|plasma membrane|recycling endosome	phosphatidylinositol binding|receptor activity			NS(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(9)|ovary(4)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(4)	33				BRCA - Breast invasive adenocarcinoma(193;1.93e-05)|Kidney(197;0.00216)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)|OV - Ovarian serous cystadenocarcinoma(275;0.0577)		CAGGTGGTCACGTGCTTGACG	0.667000													12	14					0	0	1	0	0
WFIKKN2	124857	broad.mit.edu	37	17	48918243	48918243	+	Missense_Mutation	SNP	G	G	A			TCGA-DU-A76R-01A-11D-A32B-08	TCGA-DU-A76R-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fd703fa-227d-40f8-962b-53c746b2c372	43476bb5-3d68-4d0c-9e1a-2937705a654b	g.chr17:48918243G>A	ENST00000311378.4	+	2	2122	c.1594G>A	c.(1594-1596)Gag>Aag	p.E532K	WFIKKN2_ENST00000426127.1_Missense_Mutation_p.E439K|RP11-506D12.5_ENST00000572491.2_RNA	NM_175575.5	NP_783165.1	Q8TEU8	WFKN2_HUMAN	WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2	532	NTR.					extracellular region	metalloendopeptidase inhibitor activity|protein binding|serine-type endopeptidase inhibitor activity			cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(3)|lung(13)|ovary(4)|skin(1)	29			BRCA - Breast invasive adenocarcinoma(22;1.09e-08)			CATCATGGGGGAGGTGGACGG	0.642000													7	19					0	0	1	0	0
STAMBPL1	57559	broad.mit.edu	37	10	90673204	90673204	+	Missense_Mutation	SNP	G	G	A			TCGA-DU-A76R-01A-11D-A32B-08	TCGA-DU-A76R-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fd703fa-227d-40f8-962b-53c746b2c372	43476bb5-3d68-4d0c-9e1a-2937705a654b	g.chr10:90673204G>A	ENST00000371927.3	+	6	1725	c.767G>A	c.(766-768)aGt>aAt	p.S256N	STAMBPL1_ENST00000371924.1_Missense_Mutation_p.S256N|STAMBPL1_ENST00000371922.1_Missense_Mutation_p.S90N|STAMBPL1_ENST00000371926.3_Missense_Mutation_p.S256N			Q96FJ0	STALP_HUMAN	STAM binding protein-like 1	256							metal ion binding|metallopeptidase activity|protein binding			breast(2)|endometrium(1)|large_intestine(2)|liver(2)|lung(2)|ovary(1)|skin(1)	11		Colorectal(252;0.0381)		Colorectal(12;6.38e-05)|COAD - Colon adenocarcinoma(12;7.75e-05)		GCTACTCTAAGTGCTGTTCAG	0.448000													21	27					0	0	1	0	0
TACC2	10579	broad.mit.edu	37	10	123845220	123845220	+	Missense_Mutation	SNP	G	G	A			TCGA-DU-A76R-01A-11D-A32B-08	TCGA-DU-A76R-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fd703fa-227d-40f8-962b-53c746b2c372	43476bb5-3d68-4d0c-9e1a-2937705a654b	g.chr10:123845220G>A	ENST00000369005.1	+	4	3545	c.3205G>A	c.(3205-3207)Gga>Aga	p.G1069R	TACC2_ENST00000358010.1_Intron|TACC2_ENST00000334433.3_Missense_Mutation_p.G1069R|TACC2_ENST00000515273.1_Missense_Mutation_p.G1069R|TACC2_ENST00000515603.1_Missense_Mutation_p.G1069R|TACC2_ENST00000513429.1_Intron|TACC2_ENST00000453444.2_Missense_Mutation_p.G1069R	NM_206862.2	NP_996744.2	O95359	TACC2_HUMAN	transforming, acidic coiled-coil containing protein 2	1069						microtubule organizing center|nucleus	nuclear hormone receptor binding	p.G1069R(1)		NS(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(15)|lung(27)|ovary(6)|prostate(3)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	83		all_neural(114;0.0656)|Lung NSC(174;0.136)|all_lung(145;0.17)|Breast(234;0.197)				CGCCAGCCCCGGAGTCACACC	0.642000													4	42					0	0	1	0	0
PAPPA2	60676	broad.mit.edu	37	1	176525894	176525894	+	Missense_Mutation	SNP	G	G	A			TCGA-DU-A76R-01A-11D-A32B-08	TCGA-DU-A76R-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fd703fa-227d-40f8-962b-53c746b2c372	43476bb5-3d68-4d0c-9e1a-2937705a654b	g.chr1:176525894G>A	ENST00000367662.3	+	2	1600	c.436G>A	c.(436-438)Gct>Act	p.A146T	PAPPA2_ENST00000367661.3_Missense_Mutation_p.A146T	NM_020318.2	NP_064714.2	Q9BXP8	PAPP2_HUMAN	pappalysin 2	146					cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			NS(3)|breast(3)|central_nervous_system(7)|cervix(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(19)|lung(136)|ovary(7)|pancreas(1)|prostate(4)|skin(10)|upper_aerodigestive_tract(8)|urinary_tract(1)	226						AGATGATGACGCTTATCTCGG	0.542000													14	91					0	0	1	0	0
EPPK1	83481	broad.mit.edu	37	8	144945386	144945386	+	Missense_Mutation	SNP	G	G	A	rs142055364	by1000genomes	TCGA-DU-A76R-01A-11D-A32B-08	TCGA-DU-A76R-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fd703fa-227d-40f8-962b-53c746b2c372	43476bb5-3d68-4d0c-9e1a-2937705a654b	g.chr8:144945386G>A	ENST00000525985.1	-	2	2107	c.2036C>T	c.(2035-2037)gCg>gTg	p.A679V				P58107	EPIPL_HUMAN	epiplakin 1	679						cytoplasm|cytoskeleton	protein binding|structural molecule activity			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(5)|cervix(1)|endometrium(8)|kidney(4)|large_intestine(2)|lung(30)|ovary(2)|pancreas(1)|prostate(10)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	71	all_cancers(97;1.42e-10)|all_epithelial(106;1.99e-09)|Lung NSC(106;0.000126)|all_lung(105;0.000354)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;2.88e-40)|all cancers(56;1.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			CAGCAGCTTCGCGAACACATC	0.602000													3	26					0	0	1	0	0
OS9	10956	broad.mit.edu	37	12	58087892	58087892	+	Translation_Start_Site	SNP	G	G	A			TCGA-DU-A76R-01A-11D-A32B-08	TCGA-DU-A76R-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fd703fa-227d-40f8-962b-53c746b2c372	43476bb5-3d68-4d0c-9e1a-2937705a654b	g.chr12:58087892G>A	ENST00000552285.1	+	0	155							Q13438	OS9_HUMAN	osteosarcoma amplified 9, endoplasmic reticulum lectin						ER-associated protein catabolic process|protein retention in ER lumen|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to endoplasmic reticulum stress	endoplasmic reticulum lumen|Hrd1p ubiquitin ligase complex	glycoprotein binding|protein binding|sugar binding			autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(2)|large_intestine(4)|lung(8)|ovary(2)|prostate(1)|urinary_tract(1)	21	all_neural(12;0.00548)|Glioma(12;0.0126)|Melanoma(17;0.122)		BRCA - Breast invasive adenocarcinoma(9;0.109)			TGTTGAGGCCGCTGCCTGGCT	0.532000											OREG0021950	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	3	34					0	0	1	0	0
TRPM7	54822	broad.mit.edu	37	15	50905958	50905958	+	Silent	SNP	C	C	T			TCGA-DU-A76R-01A-11D-A32B-08	TCGA-DU-A76R-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fd703fa-227d-40f8-962b-53c746b2c372	43476bb5-3d68-4d0c-9e1a-2937705a654b	g.chr15:50905958C>T	ENST00000313478.7	-	15	1997	c.1716G>A	c.(1714-1716)aaG>aaA	p.K572K	TRPM7_ENST00000560955.1_Silent_p.K572K	NM_017672.4	NP_060142.3	Q96QT4	TRPM7_HUMAN	transient receptor potential cation channel, subfamily M, member 7	572					cell death	integral to membrane	ATP binding|calcium channel activity|metal ion binding|protein serine/threonine kinase activity			breast(3)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(17)|lung(13)|ovary(4)|pancreas(1)|skin(4)|stomach(3)	52				all cancers(107;0.000819)|GBM - Glioblastoma multiforme(94;0.0045)		TCATTTTTTCCTTTTTATCTG	0.368000													4	25					0	0	1	0	0
PRPF40B	25766	broad.mit.edu	37	12	50035727	50035727	+	Missense_Mutation	SNP	G	G	A			TCGA-DU-A76R-01A-11D-A32B-08	TCGA-DU-A76R-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fd703fa-227d-40f8-962b-53c746b2c372	43476bb5-3d68-4d0c-9e1a-2937705a654b	g.chr12:50035727G>A	ENST00000261897.1	+	18	2250	c.1699G>A	c.(1699-1701)Gag>Aag	p.E567K	FMNL3_ENST00000335154.5_3'UTR|PRPF40B_ENST00000548825.2_Missense_Mutation_p.E602K|PRPF40B_ENST00000380281.1_Missense_Mutation_p.E580K			Q6NWY9	PR40B_HUMAN	PRP40 pre-mRNA processing factor 40 homolog B (S. cerevisiae)	580					mRNA processing|RNA splicing	nuclear speck				breast(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(11)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	34						CACGGCCTTTGAGGACTTCGC	0.617000													10	33					0	0	1	0	0
IDH1	3417	broad.mit.edu	37	2	209113112	209113112	+	Missense_Mutation	SNP	C	C	T	rs121913500		TCGA-DU-A76R-01A-11D-A32B-08	TCGA-DU-A76R-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fd703fa-227d-40f8-962b-53c746b2c372	43476bb5-3d68-4d0c-9e1a-2937705a654b	g.chr2:209113112C>T	ENST00000415913.1	-	4	776	c.395G>A	c.(394-396)cGt>cAt	p.R132H	IDH1_ENST00000446179.1_Missense_Mutation_p.R132H|IDH1_ENST00000345146.2_Missense_Mutation_p.R132H			O75874	IDHC_HUMAN	isocitrate dehydrogenase 1 (NADP+), soluble	132			R -> C (in colorectal cancer and glioma samples; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha- ketoglutarate but instead alpha- ketoglutarate is converted to R(-)-2- hydroxyglutarate).|R -> G (in a glioma sample; glioblastoma multiforme; somatic mutation).|R -> H (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> L (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> S (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).		2-oxoglutarate metabolic process|cellular lipid metabolic process|glyoxylate cycle|isocitrate metabolic process|NADPH regeneration|tricarboxylic acid cycle	cytosol|peroxisomal matrix	isocitrate dehydrogenase (NADP+) activity|magnesium ion binding|NAD binding|protein homodimerization activity	p.R132H(2774)|p.R132L(59)|p.R132V(1)|p.G131_R132>VL(1)		NS(1)|autonomic_ganglia(2)|biliary_tract(24)|bone(237)|central_nervous_system(3764)|endometrium(3)|haematopoietic_and_lymphoid_tissue(794)|kidney(2)|large_intestine(7)|lung(7)|prostate(6)|skin(5)|soft_tissue(12)|thyroid(22)|urinary_tract(1)	4887				Epithelial(149;0.0322)|LUSC - Lung squamous cell carcinoma(261;0.0711)|Lung(261;0.136)		ATAAGCATGACGACCTATGAT	0.393000			Mis		gliobastoma								18	32					0	0	1	0	0
RASGRF1	5923	broad.mit.edu	37	15	79292184	79292184	+	Missense_Mutation	SNP	C	C	T			TCGA-DU-A76R-01A-11D-A32B-08	TCGA-DU-A76R-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fd703fa-227d-40f8-962b-53c746b2c372	43476bb5-3d68-4d0c-9e1a-2937705a654b	g.chr15:79292184C>T	ENST00000419573.3	-	18	2969	c.2695G>A	c.(2695-2697)Gcc>Acc	p.A899T	RASGRF1_ENST00000558480.2_Missense_Mutation_p.A883T|RASGRF1_ENST00000394745.3_Missense_Mutation_p.A115T|RASGRF1_ENST00000560334.1_5'UTR	NM_002891.4	NP_002882.3	Q13972	RGRF1_HUMAN	Ras protein-specific guanine nucleotide-releasing factor 1	901					activation of Rac GTPase activity|apoptosis|induction of apoptosis by extracellular signals|long-term memory|nerve growth factor receptor signaling pathway|neuron projection development|regulation of Rac protein signal transduction|small GTPase mediated signal transduction|synaptic transmission	cytosol|growth cone|plasma membrane|synaptosome	Rho guanyl-nucleotide exchange factor activity			breast(2)|central_nervous_system(2)|endometrium(7)|kidney(4)|large_intestine(18)|lung(23)|ovary(2)|prostate(6)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	71						GCCGACAAGGCACTGCGGTTA	0.572000													28	34					0	0	1	0	0
SPTBN5	51332	broad.mit.edu	37	15	42153664	42153664	+	Missense_Mutation	SNP	G	G	A			TCGA-DU-A76R-01A-11D-A32B-08	TCGA-DU-A76R-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fd703fa-227d-40f8-962b-53c746b2c372	43476bb5-3d68-4d0c-9e1a-2937705a654b	g.chr15:42153664G>A	ENST00000320955.6	-	46	7995	c.7768C>T	c.(7768-7770)Cgt>Tgt	p.R2590C		NM_016642.2	NP_057726.4	Q9NRC6	SPTN5_HUMAN	spectrin, beta, non-erythrocytic 5	2590					actin cytoskeleton organization|actin filament capping|axon guidance	cytosol|membrane|spectrin				NS(1)|breast(1)|central_nervous_system(3)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(6)|lung(18)|ovary(5)|prostate(8)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	62		all_cancers(109;1.84e-17)|all_epithelial(112;1.12e-15)|Lung NSC(122;7.6e-10)|all_lung(180;4.15e-09)|Melanoma(134;0.0179)|Ovarian(310;0.143)|Colorectal(260;0.173)		all cancers(2;4.33e-34)|Epithelial(2;1.72e-25)|OV - Ovarian serous cystadenocarcinoma(18;8.32e-20)|GBM - Glioblastoma multiforme(94;4.69e-07)|Colorectal(2;0.00104)|COAD - Colon adenocarcinoma(120;0.0405)|READ - Rectum adenocarcinoma(92;0.0908)		CAAAGCCAACGTTCCATCTTC	0.547000													18	20					0	0	1	0	0
LARP7	51574	broad.mit.edu	37	4	113565994	113565994	+	Missense_Mutation	SNP	C	C	A			TCGA-DU-A76R-01A-11D-A32B-08	TCGA-DU-A76R-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fd703fa-227d-40f8-962b-53c746b2c372	43476bb5-3d68-4d0c-9e1a-2937705a654b	g.chr4:113565994C>A	ENST00000509061.1	+	4	493	c.190C>A	c.(190-192)Ctt>Att	p.L64I	LARP7_ENST00000344442.5_Missense_Mutation_p.L57I|LARP7_ENST00000324052.6_Missense_Mutation_p.L57I	NM_001267039.1	NP_001253968.1	Q4G0J3	LARP7_HUMAN	La ribonucleoprotein domain family, member 7	57	HTH La-type RNA-binding.				RNA processing	nucleoplasm|ribonucleoprotein complex	nucleotide binding|RNA binding			endometrium(2)|large_intestine(2)|lung(8)|ovary(4)|skin(1)	17		Ovarian(17;0.0443)|Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.000603)		GGATAGATTTCTTCGAGAACA	0.343000													16	50					1.45105e-14	1.52126e-14	1	1	0
ITPKB	3707	broad.mit.edu	37	1	226924704	226924704	+	Silent	SNP	C	C	T			TCGA-DU-A76R-01A-11D-A32B-08	TCGA-DU-A76R-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fd703fa-227d-40f8-962b-53c746b2c372	43476bb5-3d68-4d0c-9e1a-2937705a654b	g.chr1:226924704C>T	ENST00000429204.1	-	2	783	c.456G>A	c.(454-456)gcG>gcA	p.A152A	ITPKB_ENST00000272117.3_Silent_p.A152A|ITPKB_ENST00000366784.1_Silent_p.A152A	NM_002221.3	NP_002212.3	P27987	IP3KB_HUMAN	inositol-trisphosphate 3-kinase B	152							ATP binding|calmodulin binding|inositol trisphosphate 3-kinase activity	p.A152A(1)		central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(4)|lung(13)|ovary(4)|prostate(1)|skin(1)	30		Prostate(94;0.0773)				CCTGGATGTGCGCCTCAAACA	0.667000													19	73					0	0	1	0	0
TAAR8	83551	broad.mit.edu	37	6	132874313	132874313	+	Missense_Mutation	SNP	C	C	T	rs140382740		TCGA-DU-A76R-01A-11D-A32B-08	TCGA-DU-A76R-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fd703fa-227d-40f8-962b-53c746b2c372	43476bb5-3d68-4d0c-9e1a-2937705a654b	g.chr6:132874313C>T	ENST00000275200.1	+	1	482	c.482C>T	c.(481-483)aCg>aTg	p.T161M		NM_053278.1	NP_444508.1	Q969N4	TAAR8_HUMAN	trace amine associated receptor 8	161						plasma membrane	G-protein coupled receptor activity			endometrium(3)|large_intestine(2)|lung(14)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	22	Breast(56;0.112)			OV - Ovarian serous cystadenocarcinoma(155;0.00412)|GBM - Glioblastoma multiforme(226;0.00792)		CTGCCTCTCACGTACAGCGGT	0.488000													8	218					0	0	1	0	0
MYH15	22989	broad.mit.edu	37	3	108117645	108117645	+	Missense_Mutation	SNP	C	C	T			TCGA-DU-A76R-01A-11D-A32B-08	TCGA-DU-A76R-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fd703fa-227d-40f8-962b-53c746b2c372	43476bb5-3d68-4d0c-9e1a-2937705a654b	g.chr3:108117645C>T	ENST00000273353.3	-	36	5088	c.5032G>A	c.(5032-5034)Gat>Aat	p.D1678N		NM_014981.1	NP_055796.1	Q9Y2K3	MYH15_HUMAN	myosin, heavy chain 15	1678						myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			NS(1)|breast(3)|central_nervous_system(2)|cervix(4)|endometrium(10)|kidney(4)|large_intestine(14)|lung(47)|ovary(5)|pancreas(2)|prostate(6)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	105						TCCTTCAGATCACTGTTCAGT	0.522000													10	140					0	0	1	0	0
CFHR4	10877	broad.mit.edu	37	1	196871561	196871561	+	Silent	SNP	T	T	C			TCGA-DU-A76R-01A-11D-A32B-08	TCGA-DU-A76R-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fd703fa-227d-40f8-962b-53c746b2c372	43476bb5-3d68-4d0c-9e1a-2937705a654b	g.chr1:196871561T>C	ENST00000367416.2	+	2	206	c.69T>C	c.(67-69)tgT>tgC	p.C23C	CFHR4_ENST00000367418.1_Intron|CFHR4_ENST00000251424.4_Silent_p.C24C|CFHR2_ENST00000367421.3_Intron	NM_001201550.2|NM_001201551.1	NP_001188479.1|NP_001188480.1			complement factor H-related 4									p.C24*(1)|p.C23*(1)		NS(1)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(20)|ovary(1)|pancreas(1)|skin(2)|stomach(1)	36						TGAAACCTTGTGATTTTCCAG	0.279000													6	96					0	0	1	0	0
PIK3CA	5290	broad.mit.edu	37	3	178916944	178916944	+	Missense_Mutation	SNP	A	A	G			TCGA-DU-A76R-01A-11D-A32B-08	TCGA-DU-A76R-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fd703fa-227d-40f8-962b-53c746b2c372	43476bb5-3d68-4d0c-9e1a-2937705a654b	g.chr3:178916944A>G	ENST00000263967.3	+	2	488	c.331A>G	c.(331-333)Aag>Gag	p.K111E		NM_006218.2	NP_006209.2	P42336	PK3CA_HUMAN	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha	111					epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.K111E(13)|p.K111_L113delKIL(2)		NS(16)|autonomic_ganglia(4)|biliary_tract(22)|bone(1)|breast(2150)|central_nervous_system(110)|cervix(33)|endometrium(473)|eye(1)|haematopoietic_and_lymphoid_tissue(35)|kidney(14)|large_intestine(1202)|liver(42)|lung(202)|meninges(1)|oesophagus(28)|ovary(235)|pancreas(17)|penis(8)|pituitary(12)|prostate(10)|skin(155)|small_intestine(1)|soft_tissue(18)|stomach(121)|thyroid(80)|upper_aerodigestive_tract(70)|urinary_tract(208)	5269	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			CCGTGAAGAAAAGATCCTCAA	0.333000		57	Mis		"""colorectal, gastric, gliobastoma, breast"""					HNSCC(19;0.045)|TSP Lung(28;0.18)			33	48					0	0	1	0	0
SGK1	6446	broad.mit.edu	37	6	134491421	134491421	+	Silent	SNP	C	C	T			TCGA-DU-A76R-01A-11D-A32B-08	TCGA-DU-A76R-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fd703fa-227d-40f8-962b-53c746b2c372	43476bb5-3d68-4d0c-9e1a-2937705a654b	g.chr6:134491421C>T	ENST00000367858.5	-	14	2163	c.1566G>A	c.(1564-1566)acG>acA	p.T522T	SGK1_ENST00000528577.1_Silent_p.T455T|SGK1_ENST00000237305.7_Silent_p.T427T|SGK1_ENST00000367857.5_Silent_p.T417T|SGK1_ENST00000413996.3_Silent_p.T441T|SGK1_ENST00000475719.2_Silent_p.T383T	NM_001143676.1	NP_001137148.1	O00141	SGK1_HUMAN	serum/glucocorticoid regulated kinase 1	427					apoptosis|response to stress|sodium ion transport	endoplasmic reticulum|nucleus|plasma membrane	ATP binding|protein binding|protein serine/threonine kinase activity			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(21)|kidney(3)|large_intestine(3)|lung(10)|ovary(1)|skin(4)|stomach(1)	46	Colorectal(23;0.221)			OV - Ovarian serous cystadenocarcinoma(155;0.00317)|GBM - Glioblastoma multiforme(68;0.00847)		GGAAAGAGTCCGTGGGAGGCG	0.527000													8	27					0	0	1	0	0
LL22NC03-80A10.6	0	broad.mit.edu	37	22	22663086	22663086	+	RNA	SNP	T	T	G	rs1054157	by1000genomes	TCGA-DU-A76R-01A-11D-A32B-08	TCGA-DU-A76R-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fd703fa-227d-40f8-962b-53c746b2c372	43476bb5-3d68-4d0c-9e1a-2937705a654b	g.chr22:22663086T>G	ENST00000426066.1	+	0	525					NR_027293.1																						AGCTGCCACATAAGTTGTCCT	0.299000													3	31					0	0	1	0	0
GPR174	84636	broad.mit.edu	37	X	78427140	78427140	+	Silent	SNP	G	G	A			TCGA-DU-A76R-01A-11D-A32B-08	TCGA-DU-A76R-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fd703fa-227d-40f8-962b-53c746b2c372	43476bb5-3d68-4d0c-9e1a-2937705a654b	g.chrX:78427140G>A	ENST00000276077.1	+	1	672	c.636G>A	c.(634-636)ctG>ctA	p.L212L		NM_032553.1	NP_115942.1	Q9BXC1	GP174_HUMAN	G protein-coupled receptor 174	212						integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(4)|liver(1)|lung(19)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	38						TTTTATCACTGCAAGATAAAT	0.438000										HNSCC(63;0.18)			19	43					0	0	1	0	0
NCF1	653361	broad.mit.edu	37	7	74193659	74193659	+	Missense_Mutation	SNP	G	G	A			TCGA-DU-A76R-01A-11D-A32B-08	TCGA-DU-A76R-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fd703fa-227d-40f8-962b-53c746b2c372	43476bb5-3d68-4d0c-9e1a-2937705a654b	g.chr7:74193659G>A	ENST00000289473.4	+	4	356	c.286G>A	c.(286-288)Gag>Aag	p.E96K	NCF1_ENST00000443956.3_3'UTR	NM_000265.4	NP_000256.3	P14598	NCF1_HUMAN	neutrophil cytosolic factor 1	96	PX.				cell communication|cellular defense response|innate immune response|protein targeting to membrane|respiratory burst|superoxide anion generation	cytosol|NADPH oxidase complex|soluble fraction	electron carrier activity|GTP binding|GTPase activity|phosphatidylinositol binding|SH3 domain binding|superoxide-generating NADPH oxidase activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(2)|skin(3)	10						CACACTTACCGAGTACTGCGG	0.642000													4	6					0	0	1	0	0
IFT140	9742	broad.mit.edu	37	16	1614053	1614053	+	Missense_Mutation	SNP	C	C	T			TCGA-DU-A76R-01A-11D-A32B-08	TCGA-DU-A76R-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fd703fa-227d-40f8-962b-53c746b2c372	43476bb5-3d68-4d0c-9e1a-2937705a654b	g.chr16:1614053C>T	ENST00000426508.2	-	17	2375	c.2012G>A	c.(2011-2013)cGc>cAc	p.R671H	IFT140_ENST00000439987.2_5'UTR	NM_014714.3	NP_055529.2	Q96RY7	IF140_HUMAN	intraflagellar transport 140 homolog (Chlamydomonas)	671										breast(1)|central_nervous_system(2)|endometrium(7)|kidney(4)|large_intestine(12)|lung(10)|ovary(5)|pancreas(1)|prostate(4)|skin(4)|stomach(2)|urinary_tract(1)	53		Hepatocellular(780;0.219)				AGGCTGGGAGCGCGGCGTCTC	0.582000													19	49					0	0	1	0	0
NRCAM	4897	broad.mit.edu	37	7	107823282	107823282	+	Missense_Mutation	SNP	G	G	A			TCGA-DU-A76R-01A-11D-A32B-08	TCGA-DU-A76R-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fd703fa-227d-40f8-962b-53c746b2c372	43476bb5-3d68-4d0c-9e1a-2937705a654b	g.chr7:107823282G>A	ENST00000379028.3	-	23	2857	c.2387C>T	c.(2386-2388)aCa>aTa	p.T796I	NRCAM_ENST00000351718.4_Missense_Mutation_p.T780I|NRCAM_ENST00000379022.4_Missense_Mutation_p.T796I|NRCAM_ENST00000379024.4_Missense_Mutation_p.T777I|NRCAM_ENST00000413765.2_Missense_Mutation_p.T777I|NRCAM_ENST00000425651.2_Missense_Mutation_p.T796I			Q92823	NRCAM_HUMAN	neuronal cell adhesion molecule	796	Fibronectin type-III 2.				angiogenesis|axon guidance|axonal fasciculation|cell-cell adhesion|central nervous system development|clustering of voltage-gated sodium channels|neuron migration|positive regulation of neuron differentiation|regulation of axon extension|synapse assembly	external side of plasma membrane|integral to plasma membrane	ankyrin binding			breast(4)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(8)|liver(1)|lung(36)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(4)	65						AACCACAGATGTCCATTCATC	0.453000													30	40					0	0	1	0	0
LL22NC03-80A10.6	0	broad.mit.edu	37	22	22663087	22663087	+	RNA	SNP	A	A	G	rs1054158		TCGA-DU-A76R-01A-11D-A32B-08	TCGA-DU-A76R-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fd703fa-227d-40f8-962b-53c746b2c372	43476bb5-3d68-4d0c-9e1a-2937705a654b	g.chr22:22663087A>G	ENST00000426066.1	+	0	526					NR_027293.1																						GCTGCCACATAAGTTGTCCTT	0.303000													3	32					0	0	1	0	0
DZIP3	9666	broad.mit.edu	37	3	108353774	108353774	+	Silent	SNP	C	C	T			TCGA-DU-A76R-01A-11D-A32B-08	TCGA-DU-A76R-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fd703fa-227d-40f8-962b-53c746b2c372	43476bb5-3d68-4d0c-9e1a-2937705a654b	g.chr3:108353774C>T	ENST00000361582.3	+	10	1103	c.873C>T	c.(871-873)tgC>tgT	p.C291C	DZIP3_ENST00000463306.1_Silent_p.C291C	NM_014648.3	NP_055463.1	Q86Y13	DZIP3_HUMAN	DAZ interacting zinc finger protein 3	291					protein polyubiquitination	cytoplasm	polyubiquitin binding|RNA binding|ubiquitin-protein ligase activity|zinc ion binding			breast(3)|central_nervous_system(1)|endometrium(3)|large_intestine(9)|lung(21)|ovary(1)|pancreas(1)|prostate(5)|skin(1)	45						ATAAAATTTGCTGGAAAAAGT	0.308000													3	42					0	0	1	0	0
WDR72	256764	broad.mit.edu	37	15	53908182	53908182	+	Missense_Mutation	SNP	C	C	T			TCGA-DU-A76R-01A-11D-A32B-08	TCGA-DU-A76R-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fd703fa-227d-40f8-962b-53c746b2c372	43476bb5-3d68-4d0c-9e1a-2937705a654b	g.chr15:53908182C>T	ENST00000396328.1	-	15	2460	c.2221G>A	c.(2221-2223)Gca>Aca	p.A741T	WDR72_ENST00000559418.1_Missense_Mutation_p.A751T|WDR72_ENST00000557913.1_Missense_Mutation_p.A738T|WDR72_ENST00000360509.5_Missense_Mutation_p.A741T	NM_001277176.1|NM_182758.2	NP_001264105.1|NP_877435.3	Q3MJ13	WDR72_HUMAN	WD repeat domain 72	741										NS(1)|breast(1)|endometrium(4)|kidney(4)|large_intestine(18)|lung(29)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	71				all cancers(107;0.0511)		TTGGCTAGTGCCTCTGCTGAA	0.443000													9	35					0	0	1	0	0
PLCB1	23236	broad.mit.edu	37	20	8678347	8678347	+	Missense_Mutation	SNP	C	C	A			TCGA-DU-A76R-01A-11D-A32B-08	TCGA-DU-A76R-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fd703fa-227d-40f8-962b-53c746b2c372	43476bb5-3d68-4d0c-9e1a-2937705a654b	g.chr20:8678347C>A	ENST00000378641.3	+	11	1559	c.1084C>A	c.(1084-1086)Ctg>Atg	p.L362M	PLCB1_ENST00000338037.6_Missense_Mutation_p.L362M|PLCB1_ENST00000378637.2_Missense_Mutation_p.L362M	NM_182734.1	NP_877398.1	Q9NQ66	PLCB1_HUMAN	phospholipase C, beta 1 (phosphoinositide-specific)	362	PI-PLC X-box.				activation of meiosis involved in egg activation|CD24 biosynthetic process|cerebral cortex development|G1 phase|G2/M transition of mitotic cell cycle|glutamate signaling pathway|insulin-like growth factor receptor signaling pathway|interleukin-1-mediated signaling pathway|interleukin-12-mediated signaling pathway|interleukin-15-mediated signaling pathway|intracellular signal transduction|lipid catabolic process|memory|muscarinic acetylcholine receptor signaling pathway|negative regulation of monocyte extravasation|negative regulation of transcription, DNA-dependent|phosphatidylinositol metabolic process|positive regulation of acrosome reaction|positive regulation of developmental growth|positive regulation of embryonic development|positive regulation of interleukin-12 production|positive regulation of JNK cascade|positive regulation of myoblast differentiation|positive regulation of transcription, DNA-dependent|regulation of fertilization|regulation of G-protein coupled receptor protein signaling pathway|synaptic transmission	cytosol|nuclear chromatin|nuclear speck	calcium ion binding|calmodulin binding|enzyme binding|GTPase activator activity|phosphatidylinositol phospholipase C activity|phosphatidylinositol-4,5-bisphosphate binding|protein homodimerization activity|signal transducer activity			NS(2)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(11)|liver(2)|lung(41)|ovary(4)|prostate(3)|skin(12)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(4)	95						CTGTGTGGAGCTGGACTGCTG	0.483000													4	98					0.150653	0.150653	1	1	0
AHNAK	79026	broad.mit.edu	37	11	62298554	62298554	+	Missense_Mutation	SNP	G	G	A			TCGA-DU-A76R-01A-11D-A32B-08	TCGA-DU-A76R-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fd703fa-227d-40f8-962b-53c746b2c372	43476bb5-3d68-4d0c-9e1a-2937705a654b	g.chr11:62298554G>A	ENST00000378024.4	-	5	3609	c.3335C>T	c.(3334-3336)gCa>gTa	p.A1112V	AHNAK_ENST00000257247.7_Intron|AHNAK_ENST00000530124.1_Intron	NM_001620.1	NP_001611.1	Q09666	AHNK_HUMAN	AHNAK nucleoprotein	1112					nervous system development	nucleus	protein binding			NS(3)|autonomic_ganglia(1)|breast(10)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(33)|large_intestine(40)|liver(1)|lung(108)|ovary(13)|pancreas(4)|prostate(5)|skin(16)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(6)	268		Melanoma(852;0.155)				CACATCTGGTGCTTTAATATC	0.488000													23	120					0	0	1	0	0
CLTC	1213	broad.mit.edu	37	17	57744174	57744174	+	Missense_Mutation	SNP	T	T	G			TCGA-DU-A76R-01A-11D-A32B-08	TCGA-DU-A76R-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fd703fa-227d-40f8-962b-53c746b2c372	43476bb5-3d68-4d0c-9e1a-2937705a654b	g.chr17:57744174T>G	ENST00000269122.3	+	13	2238	c.1964T>G	c.(1963-1965)tTt>tGt	p.F655C	CLTC_ENST00000579456.1_Intron|CLTC_ENST00000393043.1_Missense_Mutation_p.F655C	NM_004859.3	NP_004850.1	Q00610	CLH1_HUMAN	clathrin, heavy chain (Hc)	655	Heavy chain arm.|Proximal segment.				axon guidance|epidermal growth factor receptor signaling pathway|intracellular protein transport|mitosis|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|post-Golgi vesicle-mediated transport|receptor internalization|transferrin transport	clathrin coat of coated pit|clathrin coat of trans-Golgi network vesicle|cytosol|melanosome|spindle	protein binding|structural molecule activity		CLTC/ALK(44)|CLTC/TFE3(2)	breast(2)|large_intestine(6)|ovary(1)	9	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)					GTCAACTACTTTGGTTCCTTA	0.363000			T	"""ALK, TFE3"""	"""ALCL, renal """								19	31					0	0	1	0	0
SFSWAP	6433	broad.mit.edu	37	12	132262624	132262624	+	Silent	SNP	G	G	A			TCGA-DU-A76R-01A-11D-A32B-08	TCGA-DU-A76R-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fd703fa-227d-40f8-962b-53c746b2c372	43476bb5-3d68-4d0c-9e1a-2937705a654b	g.chr12:132262624G>A	ENST00000261674.4	+	14	2298	c.2157G>A	c.(2155-2157)acG>acA	p.T719T	SFSWAP_ENST00000541286.1_Silent_p.T719T	NM_004592.3	NP_004583.2	Q12872	SFSWA_HUMAN	splicing factor, suppressor of white-apricot homolog (Drosophila)	719					mRNA splice site selection|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding|RNA binding			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(8)|ovary(1)|skin(2)	25						CCAGCACTACGCCCTGCCCTC	0.448000													10	29					0	0	1	0	0
CCL16	6360	broad.mit.edu	37	17	34304693	34304693	+	Missense_Mutation	SNP	G	G	A			TCGA-DU-A76R-01A-11D-A32B-08	TCGA-DU-A76R-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fd703fa-227d-40f8-962b-53c746b2c372	43476bb5-3d68-4d0c-9e1a-2937705a654b	g.chr17:34304693G>A	ENST00000293275.3	-	3	347	c.272C>T	c.(271-273)cCc>cTc	p.P91L		NM_004590.2	NP_004581.1	O15467	CCL16_HUMAN	chemokine (C-C motif) ligand 16	91					cell-cell signaling|immune response|inflammatory response	extracellular space	chemoattractant activity|chemokine activity			endometrium(1)|lung(2)	3		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		AGGTAGGTTGGGATCCTTGAT	0.507000													30	87					0	0	1	0	0
NBPF10	100132406	broad.mit.edu	37	1	145367739	145367739	+	Silent	SNP	A	A	G	rs146714035	by1000genomes	TCGA-DU-A76R-01A-11D-A32B-08	TCGA-DU-A76R-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fd703fa-227d-40f8-962b-53c746b2c372	43476bb5-3d68-4d0c-9e1a-2937705a654b	g.chr1:145367739A>G	ENST00000342960.5	+	83	10370	c.10335A>G	c.(10333-10335)aaA>aaG	p.K3445K	NBPF10_ENST00000369338.1_Intron|NBPF10_ENST00000369339.2_Intron	NM_001039703.4	NP_001034792.4	A6NDV3	A6NDV3_HUMAN	neuroblastoma breakpoint family, member 10	3445								p.K3445K(4)		NS(3)|breast(1)|central_nervous_system(3)|endometrium(12)|kidney(23)|lung(15)|ovary(1)|prostate(7)|skin(6)|urinary_tract(2)	73	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		ggaaggggaaaaaaagaaggg	0.413000													3	62					0	0	1	0	0
ZNF574	64763	broad.mit.edu	37	19	42584408	42584408	+	Silent	SNP	C	C	G			TCGA-DU-A76R-01A-11D-A32B-08	TCGA-DU-A76R-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fd703fa-227d-40f8-962b-53c746b2c372	43476bb5-3d68-4d0c-9e1a-2937705a654b	g.chr19:42584408C>G	ENST00000600245.1	+	2	2305	c.1650C>G	c.(1648-1650)ccC>ccG	p.P550P	ZNF574_ENST00000222339.7_Silent_p.P640P|ZNF574_ENST00000359044.4_Silent_p.P550P			Q6ZN55	ZN574_HUMAN	zinc finger protein 574	550					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(4)|kidney(1)|large_intestine(3)|lung(6)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	20		Prostate(69;0.059)				GAGAGCGGCCCTACCGGTGTG	0.647000													51	25					0	0	1	0	0
CHST15	51363	broad.mit.edu	37	10	125804102	125804102	+	Missense_Mutation	SNP	G	G	A			TCGA-DU-A76R-01A-11D-A32B-08	TCGA-DU-A76R-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fd703fa-227d-40f8-962b-53c746b2c372	43476bb5-3d68-4d0c-9e1a-2937705a654b	g.chr10:125804102G>A	ENST00000346248.5	-	3	1522	c.880C>T	c.(880-882)Cgc>Tgc	p.R294C	CHST15_ENST00000421115.1_Missense_Mutation_p.R294C|CHST15_ENST00000435907.1_Missense_Mutation_p.R294C	NM_001270764.1|NM_015892.3	NP_001257693.1|NP_056976.2	Q7LFX5	CHSTF_HUMAN	carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15	294					hexose biosynthetic process	Golgi membrane|integral to membrane	3'-phosphoadenosine 5'-phosphosulfate binding|N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity			endometrium(4)|kidney(1)|large_intestine(11)|lung(6)|ovary(3)|stomach(1)	26						TCACCAAAGCGCTTCCGGGTC	0.637000													6	9					0	0	1	0	0
ZNF563	147837	broad.mit.edu	37	19	12430201	12430201	+	Missense_Mutation	SNP	C	C	T	rs113773973	byFrequency	TCGA-DU-A76R-01A-11D-A32B-08	TCGA-DU-A76R-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fd703fa-227d-40f8-962b-53c746b2c372	43476bb5-3d68-4d0c-9e1a-2937705a654b	g.chr19:12430201C>T	ENST00000293725.5	-	4	843	c.638G>A	c.(637-639)cGt>cAt	p.R213H	ZNF563_ENST00000595977.1_Intron	NM_145276.2	NP_660319.1	Q8TA94	ZN563_HUMAN	zinc finger protein 563	213					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(4)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	20						TTCATGCATACGTAATAAACT	0.393000													55	77					0	0	1	0	0
MYH2	4620	broad.mit.edu	37	17	10432210	10432210	+	Missense_Mutation	SNP	G	G	A			TCGA-DU-A76R-01A-11D-A32B-08	TCGA-DU-A76R-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fd703fa-227d-40f8-962b-53c746b2c372	43476bb5-3d68-4d0c-9e1a-2937705a654b	g.chr17:10432210G>A	ENST00000245503.5	-	27	3925	c.3541C>T	c.(3541-3543)Cgc>Tgc	p.R1181C	CTC-297N7.7_ENST00000399342.2_RNA|CTC-297N7.7_ENST00000581304.1_RNA|CTC-297N7.7_ENST00000587182.1_RNA|MYH2_ENST00000532183.1_Intron|MYH2_ENST00000397183.2_Missense_Mutation_p.R1181C	NM_017534.5	NP_060004.3	Q9UKX2	MYH2_HUMAN	myosin, heavy chain 2, skeletal muscle, adult	1181					muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(16)|lung(99)|ovary(6)|pancreas(4)|prostate(3)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(4)	176						AGGTCCCTGCGCATTTTCTGG	0.592000													26	125					0	0	1	0	0
SRM	6723	broad.mit.edu	37	1	11115092	11115092	+	Missense_Mutation	SNP	G	G	A			TCGA-DU-A76R-01A-11D-A32B-08	TCGA-DU-A76R-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fd703fa-227d-40f8-962b-53c746b2c372	43476bb5-3d68-4d0c-9e1a-2937705a654b	g.chr1:11115092G>A	ENST00000376957.2	-	7	895	c.815C>T	c.(814-816)gCg>gTg	p.A272V		NM_003132.2	NP_003123.2	P19623	SPEE_HUMAN	spermidine synthase	272					spermidine biosynthetic process	cytosol	protein homodimerization activity|spermidine synthase activity			large_intestine(1)|lung(1)|urinary_tract(1)	3	Ovarian(185;0.249)	Lung NSC(185;1.74e-05)|all_lung(284;2.05e-05)|Renal(390;0.000147)|Colorectal(325;0.00205)|Breast(348;0.00262)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)	STAD - Stomach adenocarcinoma(5;0.228)	UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.14e-07)|COAD - Colon adenocarcinoma(227;7.11e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000294)|Kidney(185;0.000728)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|READ - Rectum adenocarcinoma(331;0.0487)|STAD - Stomach adenocarcinoma(313;0.192)	S-Adenosylmethionine(DB00118)|Spermine(DB00127)	CTGCATCTGCGCCACCTGCTG	0.632000													22	7					0	0	1	0	0
AC073321.4	0	broad.mit.edu	37	2	217475010	217475010	+	RNA	DEL	G	G	-			TCGA-DU-A76R-01A-11D-A32B-08	TCGA-DU-A76R-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fd703fa-227d-40f8-962b-53c746b2c372	43476bb5-3d68-4d0c-9e1a-2937705a654b	g.chr2:217475010delG	ENST00000441803.1	+	0	195																											ttttttttttGAAAGAAAGGC	0.393													2	4	---	---	---	---					
ANTXR2	118429	broad.mit.edu	37	4	80905990	80905990	+	Frame_Shift_Del	DEL	C	C	-	rs12647691	by1000genomes	TCGA-DU-A76R-01A-11D-A32B-08	TCGA-DU-A76R-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fd703fa-227d-40f8-962b-53c746b2c372	43476bb5-3d68-4d0c-9e1a-2937705a654b	g.chr4:80905990delC	ENST00000403729.2	-	13	1594	c.1069delG	c.(1069-1071)ccfs	p.A357fs	ANTXR2_ENST00000307333.7_Frame_Shift_Del_p.A357fs|ANTXR2_ENST00000404191.1_Frame_Shift_Del_p.A280fs|ANTXR2_ENST00000346652.6_Frame_Shift_Del_p.A254fs	NM_058172.5	NP_477520.2	P58335	ANTR2_HUMAN	anthrax toxin receptor 2	357	Poly-Pro.		A -> P (in dbSNP:rs12647691).			endoplasmic reticulum membrane|extracellular region|integral to membrane|plasma membrane	metal ion binding|protein binding|receptor activity			endometrium(2)|kidney(1)|large_intestine(2)|lung(7)|ovary(1)	13						GGTGCAGGGGCGGGTGGTGGT	0.348									Juvenile Hyaline Fibromatosis				4	9	---	---	---	---					
LRRN4	164312	broad.mit.edu	37	20	6033401	6033401	+	Frame_Shift_Del	DEL	G	G	-			TCGA-DU-A76R-01A-11D-A32B-08	TCGA-DU-A76R-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fd703fa-227d-40f8-962b-53c746b2c372	43476bb5-3d68-4d0c-9e1a-2937705a654b	g.chr20:6033401delG	ENST00000378858.4	-	2	269	c.45delC	c.(43-45)ccfs	p.P15fs		NM_152611.4	NP_689824.2	Q8WUT4	LRRN4_HUMAN	leucine rich repeat neuronal 4	15						integral to membrane				breast(1)|endometrium(3)|large_intestine(3)|lung(10)|ovary(2)|prostate(1)|skin(5)|urinary_tract(2)	27						CTGCCCAGCTGGGGCGCAGCA	0.682													2	4	---	---	---	---					
HDX	139324	broad.mit.edu	37	X	83730327	83730331	+	Frame_Shift_Del	DEL	TTTGA	TTTGA	-			TCGA-DU-A76R-01A-11D-A32B-08	TCGA-DU-A76R-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6fd703fa-227d-40f8-962b-53c746b2c372	43476bb5-3d68-4d0c-9e1a-2937705a654b	g.chrX:83730327_83730331delTTTGA	ENST00000297977.5	-	2	186_190	c.75_79delTCAAA	c.(73-81)aagtfs	p.NQS25fs	HDX_ENST00000373177.2_Frame_Shift_Del_p.NQS25fs|HDX_ENST00000506585.2_Intron	NM_001177479.1|NM_144657.4	NP_001170950.1|NP_653258.2	Q7Z353	HDX_HUMAN	highly divergent homeobox	25						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(6)|kidney(2)|large_intestine(12)|liver(1)|lung(19)|ovary(1)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	48						CAATTTTTACTTTGATTTGTCATTC	0.327													8	28	---	---	---	---