Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
ANKRD20A5P	0	broad.mit.edu	37	18	14179589	14179589	+	RNA	SNP	C	C	A			TCGA-DH-A7UR-01A-11D-A33T-08	TCGA-DH-A7UR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f04342d6-2f32-40ec-a731-3e7bd18ffffe	bfcd7244-5a98-40a6-9328-e7fe970754e9	g.chr18:14179589C>A	ENST00000581935.1	+	0	494																				lung(3)	3						CCTGGACAAGCAGCACAGGTA	0.697000													7	25					1.04858e-14	1.10049e-14	1	1	0
TIGD3	220359	broad.mit.edu	37	11	65124210	65124210	+	Missense_Mutation	SNP	C	C	T			TCGA-DH-A7UR-01A-11D-A33T-08	TCGA-DH-A7UR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f04342d6-2f32-40ec-a731-3e7bd18ffffe	bfcd7244-5a98-40a6-9328-e7fe970754e9	g.chr11:65124210C>T	ENST00000309880.5	+	2	1138	c.931C>T	c.(931-933)Cgg>Tgg	p.R311W		NM_145719.2	NP_663771.1	Q6B0B8	TIGD3_HUMAN	tigger transposable element derived 3	311	DDE.				regulation of transcription, DNA-dependent	chromosome, centromeric region|nucleus	DNA binding			endometrium(3)|large_intestine(1)|lung(9)|prostate(2)|skin(2)	17						TTACCGACACCGGCTGTTGGG	0.667000													5	71					0	0	1	0	0
HOXA1	3198	broad.mit.edu	37	7	27134078	27134078	+	Missense_Mutation	SNP	G	G	A			TCGA-DH-A7UR-01A-11D-A33T-08	TCGA-DH-A7UR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f04342d6-2f32-40ec-a731-3e7bd18ffffe	bfcd7244-5a98-40a6-9328-e7fe970754e9	g.chr7:27134078G>A	ENST00000343060.4	-	2	1050	c.989C>T	c.(988-990)aCt>aTt	p.T330I	HOXA1_ENST00000355633.5_3'UTR	NM_005522.4	NP_005513.1	P49639	HXA1_HUMAN	homeobox A1	330						nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(2)|kidney(2)|large_intestine(4)|liver(1)|lung(14)|ovary(4)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	31						GGTAGTCAGAGTGTCTGAGGT	0.597000													38	57					0	0	1	0	0
RADIL	55698	broad.mit.edu	37	7	4874838	4874838	+	Silent	SNP	C	C	T			TCGA-DH-A7UR-01A-11D-A33T-08	TCGA-DH-A7UR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f04342d6-2f32-40ec-a731-3e7bd18ffffe	bfcd7244-5a98-40a6-9328-e7fe970754e9	g.chr7:4874838C>T	ENST00000399583.3	-	4	1003	c.816G>A	c.(814-816)cgG>cgA	p.R272R	RADIL_ENST00000536091.1_Silent_p.R272R|RADIL_ENST00000538469.1_Silent_p.R32R	NM_018059.4	NP_060529.4	Q96JH8	RADIL_HUMAN	Ras association and DIL domains	272					cell adhesion|multicellular organismal development|signal transduction		protein binding			NS(1)|biliary_tract(2)|breast(1)|central_nervous_system(3)|endometrium(2)|large_intestine(2)|lung(22)|pancreas(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	41		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0986)|OV - Ovarian serous cystadenocarcinoma(56;7.41e-15)		CCACCGTGTGCCGGTCCCGGT	0.652000													3	29					0	0	1	0	0
FSCB	84075	broad.mit.edu	37	14	44973903	44973903	+	Missense_Mutation	SNP	G	G	A			TCGA-DH-A7UR-01A-11D-A33T-08	TCGA-DH-A7UR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f04342d6-2f32-40ec-a731-3e7bd18ffffe	bfcd7244-5a98-40a6-9328-e7fe970754e9	g.chr14:44973903G>A	ENST00000340446.4	-	1	2579	c.2288C>T	c.(2287-2289)cCg>cTg	p.P763L		NM_032135.3	NP_115511.3	Q5H9T9	FSCB_HUMAN	fibrous sheath CABYR binding protein	763						cilium				breast(4)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(10)|lung(47)|ovary(2)|pancreas(1)|prostate(5)|skin(5)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(1)	89				GBM - Glioblastoma multiforme(112;0.128)		TGCCACCTGCGGTGACTGAAA	0.433000													33	192					0	0	1	0	0
LPAR4	2846	broad.mit.edu	37	X	78011462	78011462	+	Silent	SNP	C	C	T			TCGA-DH-A7UR-01A-11D-A33T-08	TCGA-DH-A7UR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f04342d6-2f32-40ec-a731-3e7bd18ffffe	bfcd7244-5a98-40a6-9328-e7fe970754e9	g.chrX:78011462C>T	ENST00000435339.2	+	2	1501	c.1096C>T	c.(1096-1098)Cta>Tta	p.L366L	LPAR4_ENST00000373301.2_Silent_p.L366L	NM_005296.2	NP_005287.1	Q99677	LPAR4_HUMAN	lysophosphatidic acid receptor 4	366						integral to plasma membrane	lipid binding|purinergic nucleotide receptor activity, G-protein coupled			breast(3)|endometrium(3)|kidney(4)|large_intestine(4)|lung(16)|ovary(4)|pancreas(1)|skin(1)|upper_aerodigestive_tract(2)	38						TGAATTAATGCTAGAATCCAC	0.363000													8	123					0	0	1	0	0
KRTAP4-11	653240	broad.mit.edu	37	17	39274087	39274087	+	Missense_Mutation	SNP	G	G	C	rs141357429	by1000genomes	TCGA-DH-A7UR-01A-11D-A33T-08	TCGA-DH-A7UR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f04342d6-2f32-40ec-a731-3e7bd18ffffe	bfcd7244-5a98-40a6-9328-e7fe970754e9	g.chr17:39274087G>C	ENST00000391413.2	-	1	519	c.481C>G	c.(481-483)Ctg>Gtg	p.L161V		NM_033059.3	NP_149048.2	Q9BYQ6	KR411_HUMAN	keratin associated protein 4-11	161	27 X 5 AA repeats of C-C-[GIKRQVHEL]- [SPTR]-[STVQRMC].					keratin filament		p.L161V(1)		endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|lung(8)|prostate(5)|skin(1)	33		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000371)			ACTGGACGCAGGcagcagcag	0.657000													4	26					0	0	1	0	0
NAP1L2	4674	broad.mit.edu	37	X	72433893	72433893	+	Missense_Mutation	SNP	G	G	A			TCGA-DH-A7UR-01A-11D-A33T-08	TCGA-DH-A7UR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f04342d6-2f32-40ec-a731-3e7bd18ffffe	bfcd7244-5a98-40a6-9328-e7fe970754e9	g.chrX:72433893G>A	ENST00000373517.3	-	1	791	c.436C>T	c.(436-438)Ccc>Tcc	p.P146S	NAP1L2_ENST00000536638.1_Missense_Mutation_p.P4S	NM_021963.3	NP_068798.1	Q9ULW6	NP1L2_HUMAN	nucleosome assembly protein 1-like 2	146					nucleosome assembly	chromatin assembly complex				NS(1)|breast(2)|endometrium(2)|kidney(3)|large_intestine(6)|lung(12)|skin(3)	29	Renal(35;0.156)					TCCAGTAAGGGTTGGTACATT	0.383000													102	182					0	0	1	0	0
CXorf58	254158	broad.mit.edu	37	X	23953455	23953455	+	Missense_Mutation	SNP	G	G	A			TCGA-DH-A7UR-01A-11D-A33T-08	TCGA-DH-A7UR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f04342d6-2f32-40ec-a731-3e7bd18ffffe	bfcd7244-5a98-40a6-9328-e7fe970754e9	g.chrX:23953455G>A	ENST00000379211.3	+	7	1247	c.698G>A	c.(697-699)cGt>cAt	p.R233H		NM_001169574.1|NM_152761.2	NP_001163045.1|NP_689974.2	Q96LI9	CX058_HUMAN	chromosome X open reading frame 58	233										breast(2)|endometrium(2)|kidney(1)|large_intestine(6)|lung(2)|prostate(1)	14						ATCTCAAACCGTCTACGAAAT	0.373000													7	199					0	0	1	0	0
SLC6A10P	0	broad.mit.edu	37	16	32890622	32890622	+	RNA	SNP	T	T	G			TCGA-DH-A7UR-01A-11D-A33T-08	TCGA-DH-A7UR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f04342d6-2f32-40ec-a731-3e7bd18ffffe	bfcd7244-5a98-40a6-9328-e7fe970754e9	g.chr16:32890622T>G	ENST00000330048.5	-	0	3176					NR_003083.2																						CGTTGGTGTTTTTGTAGACCA	0.617000													3	39					0	0	1	0	0
NUDT11	0	broad.mit.edu	37	X	51239216	51239216	+	Silent	SNP	G	G	A			TCGA-DH-A7UR-01A-11D-A33T-08	TCGA-DH-A7UR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f04342d6-2f32-40ec-a731-3e7bd18ffffe	bfcd7244-5a98-40a6-9328-e7fe970754e9	g.chrX:51239216G>A	ENST00000375992.3	-	1	232	c.81C>T	c.(79-81)agC>agT	p.S27S		NM_018159.3	NP_060629.2	Q96G61	NUD11_HUMAN	nudix (nucleoside diphosphate linked moiety X)-type motif 11	27	Nudix hydrolase.					cytoplasm	diphosphoinositol-polyphosphate diphosphatase activity|metal ion binding			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(2)|prostate(1)|upper_aerodigestive_tract(2)	9	Ovarian(276;0.236)					CCTCGCGTTCGCTCCGGAAGC	0.682000										HNSCC(48;0.14)			19	32					0	0	1	0	0
HECTD2	143279	broad.mit.edu	37	10	93247529	93247529	+	Silent	SNP	C	C	T			TCGA-DH-A7UR-01A-11D-A33T-08	TCGA-DH-A7UR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f04342d6-2f32-40ec-a731-3e7bd18ffffe	bfcd7244-5a98-40a6-9328-e7fe970754e9	g.chr10:93247529C>T	ENST00000446394.1	+	12	1297	c.1197C>T	c.(1195-1197)atC>atT	p.I399I	HECTD2_ENST00000498446.1_3'UTR|HECTD2_ENST00000371667.1_Silent_p.I45I|HECTD2_ENST00000298068.5_Silent_p.I395I|HECTD2_ENST00000536715.1_Intron			Q5U5R9	HECD2_HUMAN	HECT domain containing E3 ubiquitin protein ligase 2	395					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	intracellular	ubiquitin-protein ligase activity	p.I395I(1)		breast(2)|endometrium(2)|kidney(4)|large_intestine(10)|lung(7)|skin(1)|urinary_tract(1)	27						TGATAAACATCGCAAGGGTAA	0.313000													25	151					0	0	1	0	0
DST	667	broad.mit.edu	37	6	56382032	56382032	+	Missense_Mutation	SNP	C	C	T			TCGA-DH-A7UR-01A-11D-A33T-08	TCGA-DH-A7UR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f04342d6-2f32-40ec-a731-3e7bd18ffffe	bfcd7244-5a98-40a6-9328-e7fe970754e9	g.chr6:56382032C>T	ENST00000370754.5	-	71	18227	c.18228G>A	c.(18226-18228)atG>atA	p.M6076I	DST_ENST00000340834.4_5'UTR|DST_ENST00000446842.2_Missense_Mutation_p.M5572I|DST_ENST00000312431.6_3'UTR|DST_ENST00000421834.2_Missense_Mutation_p.M3810I|DST_ENST00000244364.6_Missense_Mutation_p.M3484I|DST_ENST00000370769.4_Missense_Mutation_p.M5898I|DST_ENST00000370788.2_Missense_Mutation_p.M3701I|DST_ENST00000361203.3_Missense_Mutation_p.M5787I			Q03001	DYST_HUMAN	dystonin	5896					cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			NS(1)|breast(5)|central_nervous_system(8)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(22)|lung(43)|ovary(7)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)	105	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			TGCATGCGGTCATGATTTTAT	0.378000													80	178					0	0	1	0	0
TENM3	55714	broad.mit.edu	37	4	183713841	183713841	+	Missense_Mutation	SNP	C	C	T			TCGA-DH-A7UR-01A-11D-A33T-08	TCGA-DH-A7UR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f04342d6-2f32-40ec-a731-3e7bd18ffffe	bfcd7244-5a98-40a6-9328-e7fe970754e9	g.chr4:183713841C>T	ENST00000511685.1	+	26	6139	c.6016C>T	c.(6016-6018)Cgc>Tgc	p.R2006C	TENM3_ENST00000406950.2_Missense_Mutation_p.R2006C					teneurin transmembrane protein 3																		GCAGATTTTCCGCTTTAGTGA	0.438000													37	378					0	0	1	0	0
EEF1B2	1933	broad.mit.edu	37	2	207025366	207025366	+	Silent	SNP	G	G	A			TCGA-DH-A7UR-01A-11D-A33T-08	TCGA-DH-A7UR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f04342d6-2f32-40ec-a731-3e7bd18ffffe	bfcd7244-5a98-40a6-9328-e7fe970754e9	g.chr2:207025366G>A	ENST00000392222.2	+	2	510	c.135G>A	c.(133-135)ccG>ccA	p.P45P	EEF1B2_ENST00000392221.1_Silent_p.P45P|EEF1B2_ENST00000236957.5_Silent_p.P45P	NM_001959.3	NP_001950.1	P24534	EF1B_HUMAN	eukaryotic translation elongation factor 1 beta 2	45	GST C-terminal.					cytosol|eukaryotic translation elongation factor 1 complex	protein binding|translation elongation factor activity	p.P45P(5)		breast(1)|endometrium(5)|kidney(3)|large_intestine(1)|lung(6)	16						CCAGCCCACCGCCTGCCGACT	0.448000													4	164					0	0	1	0	0
MUC17	140453	broad.mit.edu	37	7	100681328	100681328	+	Missense_Mutation	SNP	C	C	T			TCGA-DH-A7UR-01A-11D-A33T-08	TCGA-DH-A7UR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f04342d6-2f32-40ec-a731-3e7bd18ffffe	bfcd7244-5a98-40a6-9328-e7fe970754e9	g.chr7:100681328C>T	ENST00000306151.4	+	3	6695	c.6631C>T	c.(6631-6633)Cca>Tca	p.P2211S		NM_001040105.1	NP_001035194.1	Q685J3	MUC17_HUMAN	mucin 17, cell surface associated	2211	59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			NS(3)|breast(14)|central_nervous_system(2)|cervix(2)|endometrium(27)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(28)|lung(179)|ovary(19)|pancreas(1)|prostate(13)|skin(26)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	343	Lung NSC(181;0.136)|all_lung(186;0.182)					TACCAGCATGCCAACCTCAAC	0.498000													7	814					0	0	1	0	0
LRRC14B	389257	broad.mit.edu	37	5	195061	195061	+	Missense_Mutation	SNP	C	C	G			TCGA-DH-A7UR-01A-11D-A33T-08	TCGA-DH-A7UR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f04342d6-2f32-40ec-a731-3e7bd18ffffe	bfcd7244-5a98-40a6-9328-e7fe970754e9	g.chr5:195061C>G	ENST00000328278.3	+	2	1166	c.1138C>G	c.(1138-1140)Ctg>Gtg	p.L380V		NM_001080478.1	NP_001073947.1	A6NHZ5	LR14B_HUMAN	leucine rich repeat containing 14B	380										endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|skin(1)|upper_aerodigestive_tract(2)	10						CGTTGGCATGCTGATCCTGGG	0.667000													8	26					0	0	1	0	0
PSD4	23550	broad.mit.edu	37	2	113940279	113940279	+	Silent	SNP	C	C	T	rs147089589		TCGA-DH-A7UR-01A-11D-A33T-08	TCGA-DH-A7UR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f04342d6-2f32-40ec-a731-3e7bd18ffffe	bfcd7244-5a98-40a6-9328-e7fe970754e9	g.chr2:113940279C>T	ENST00000245796.6	+	2	441	c.246C>T	c.(244-246)gaC>gaT	p.D82D	PSD4_ENST00000465917.1_3'UTR|PSD4_ENST00000441564.2_Silent_p.D82D	NM_012455.2	NP_036587.2	Q8NDX1	PSD4_HUMAN	pleckstrin and Sec7 domain containing 4	82					regulation of ARF protein signal transduction	cytoplasm|plasma membrane	ARF guanyl-nucleotide exchange factor activity			cervix(1)|endometrium(2)|large_intestine(4)|lung(13)|ovary(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29						TCCATCAGGACGGGCTGGAGC	0.622000													4	55					0	0	1	0	0
CLASP1	23332	broad.mit.edu	37	2	122125380	122125380	+	Missense_Mutation	SNP	G	G	A			TCGA-DH-A7UR-01A-11D-A33T-08	TCGA-DH-A7UR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f04342d6-2f32-40ec-a731-3e7bd18ffffe	bfcd7244-5a98-40a6-9328-e7fe970754e9	g.chr2:122125380G>A	ENST00000263710.4	-	35	4059	c.3670C>T	c.(3670-3672)Cct>Tct	p.P1224S	CLASP1_ENST00000397587.3_Missense_Mutation_p.P1164S|CLASP1_ENST00000541377.1_Missense_Mutation_p.P1163S|CLASP1_ENST00000455322.2_Missense_Mutation_p.P1180S|CLASP1_ENST00000541859.1_Missense_Mutation_p.P941S|CLASP1_ENST00000545861.1_Missense_Mutation_p.P931S|CLASP1_ENST00000409078.3_Missense_Mutation_p.P1157S	NM_015282.2	NP_056097.1	Q7Z460	CLAP1_HUMAN	cytoplasmic linker associated protein 1	1224					axon guidance|cell division|establishment or maintenance of cell polarity|exit from mitosis|G2/M transition of mitotic cell cycle|microtubule anchoring|microtubule bundle formation|microtubule nucleation|microtubule organizing center organization|mitotic prometaphase|negative regulation of microtubule depolymerization	centrosomal corona|condensed chromosome kinetochore|cortical microtubule cytoskeleton|cytoplasmic microtubule|cytosol|Golgi apparatus|kinetochore microtubule	kinetochore binding|microtubule plus-end binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(8)|kidney(4)|large_intestine(8)|lung(19)|ovary(1)|prostate(1)	47	Renal(3;0.0496)					TCAGTGGCAGGGGAGGCAGCG	0.582000													38	57					0	0	1	0	0
PKP2	5318	broad.mit.edu	37	12	33031009	33031009	+	Missense_Mutation	SNP	C	C	T			TCGA-DH-A7UR-01A-11D-A33T-08	TCGA-DH-A7UR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f04342d6-2f32-40ec-a731-3e7bd18ffffe	bfcd7244-5a98-40a6-9328-e7fe970754e9	g.chr12:33031009C>T	ENST00000340811.4	-	3	913	c.805G>A	c.(805-807)Ggg>Agg	p.G269R	PKP2_ENST00000070846.6_Missense_Mutation_p.G269R	NM_001005242.2	NP_001005242.2	Q99959	PKP2_HUMAN	plakophilin 2	269					cell-cell adhesion	desmosome|integral to membrane|nucleus	binding			NS(1)|breast(2)|endometrium(1)|kidney(9)|large_intestine(8)|lung(21)|ovary(1)|pancreas(2)|prostate(2)|skin(2)|urinary_tract(1)	50	Lung NSC(5;9.35e-07)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.239)					CTGACCTGCCCGACAGTGAGC	0.662000													10	59					0	0	1	0	0
IDH2	3418	broad.mit.edu	37	15	90631839	90631839	+	Missense_Mutation	SNP	T	T	C			TCGA-DH-A7UR-01A-11D-A33T-08	TCGA-DH-A7UR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f04342d6-2f32-40ec-a731-3e7bd18ffffe	bfcd7244-5a98-40a6-9328-e7fe970754e9	g.chr15:90631839T>C	ENST00000330062.3	-	4	627	c.514A>G	c.(514-516)Agg>Ggg	p.R172G	IDH2_ENST00000540499.2_Missense_Mutation_p.R120G|IDH2_ENST00000559482.1_Intron|IDH2_ENST00000539790.1_Missense_Mutation_p.R42G	NM_002168.2	NP_002159.2	P48735	IDHP_HUMAN	isocitrate dehydrogenase 2 (NADP+), mitochondrial	172					2-oxoglutarate metabolic process|glyoxylate cycle|isocitrate metabolic process|tricarboxylic acid cycle	mitochondrial matrix	isocitrate dehydrogenase (NADP+) activity|magnesium ion binding|NAD binding	p.R172W(12)|p.R172G(2)		biliary_tract(11)|bone(19)|central_nervous_system(107)|endometrium(1)|haematopoietic_and_lymphoid_tissue(953)|large_intestine(8)|lung(5)|skin(5)	1109	Melanoma(11;0.00551)|Lung NSC(78;0.0196)|all_lung(78;0.04)		BRCA - Breast invasive adenocarcinoma(143;0.0146)|KIRC - Kidney renal clear cell carcinoma(17;0.0286)|Kidney(142;0.0514)|STAD - Stomach adenocarcinoma(125;0.106)			TGGGCGTGCCTGCCAATGGTG	0.627000			M		GBM								45	78					0	0	1	0	0
SV2C	22987	broad.mit.edu	37	5	75505623	75505623	+	Missense_Mutation	SNP	G	G	A			TCGA-DH-A7UR-01A-11D-A33T-08	TCGA-DH-A7UR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f04342d6-2f32-40ec-a731-3e7bd18ffffe	bfcd7244-5a98-40a6-9328-e7fe970754e9	g.chr5:75505623G>A	ENST00000502798.2	+	4	1266	c.824G>A	c.(823-825)cGg>cAg	p.R275Q	SV2C_ENST00000322285.7_Missense_Mutation_p.R275Q	NM_014979.1	NP_055794.1	Q496J9	SV2C_HUMAN	synaptic vesicle glycoprotein 2C	275					neurotransmitter transport	cell junction|integral to membrane|synaptic vesicle membrane	transmembrane transporter activity			NS(1)|breast(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(5)|lung(14)|ovary(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	37		all_lung(232;0.007)|Lung NSC(167;0.0148)|Ovarian(174;0.0798)|Prostate(461;0.184)		OV - Ovarian serous cystadenocarcinoma(47;1.16e-50)|all cancers(79;7.25e-40)		CGGGAAAAGCGGGGCGAACAC	0.557000													4	102					0	0	1	0	0
AKR1CL1	340811	broad.mit.edu	37	10	5204929	5204929	+	Missense_Mutation	SNP	G	G	A	rs150568767		TCGA-DH-A7UR-01A-11D-A33T-08	TCGA-DH-A7UR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f04342d6-2f32-40ec-a731-3e7bd18ffffe	bfcd7244-5a98-40a6-9328-e7fe970754e9	g.chr10:5204929G>A	ENST00000334314.3	-	2	224	c.148C>T	c.(148-150)Cgc>Tgc	p.R50C						aldo-keto reductase family 1, member C-like 1											cervix(1)|endometrium(1)|large_intestine(2)|lung(2)	6						TCAATATGGCGGAAGCCTACG	0.468000													68	147					0	0	1	0	0
CCNE1	898	broad.mit.edu	37	19	30313174	30313174	+	Missense_Mutation	SNP	G	G	A			TCGA-DH-A7UR-01A-11D-A33T-08	TCGA-DH-A7UR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f04342d6-2f32-40ec-a731-3e7bd18ffffe	bfcd7244-5a98-40a6-9328-e7fe970754e9	g.chr19:30313174G>A	ENST00000262643.3	+	10	1147	c.868G>A	c.(868-870)Gac>Aac	p.D290N	CCNE1_ENST00000357943.5_Missense_Mutation_p.D247N|CCNE1_ENST00000444983.2_Missense_Mutation_p.D275N	NM_001238.2	NP_001229.1	P24864	CCNE1_HUMAN	cyclin E1	290					androgen receptor signaling pathway|cell division|positive regulation of transcription, DNA-dependent|regulation of cyclin-dependent protein kinase activity|regulation of transcription involved in G1/S phase of mitotic cell cycle	cytosol|nucleoplasm	androgen receptor binding|protein kinase binding|transcription coactivator activity			endometrium(1)|kidney(2)|large_intestine(4)|lung(12)|skin(1)	20	all_cancers(1;2.19e-31)|all_epithelial(1;1.49e-30)|all_lung(1;1.37e-11)|Lung NSC(1;2.35e-11)|Ovarian(5;0.000902)|Breast(6;0.0203)|Esophageal squamous(110;0.195)		UCEC - Uterine corpus endometrioid carcinoma (4;2.65e-06)|Epithelial(1;6.85e-98)|all cancers(1;1.38e-94)|OV - Ovarian serous cystadenocarcinoma(1;1.38e-90)|STAD - Stomach adenocarcinoma(5;5.8e-07)|GBM - Glioblastoma multiforme(4;0.0394)|Lung(7;0.092)|LUAD - Lung adenocarcinoma(5;0.115)|BRCA - Breast invasive adenocarcinoma(6;0.183)|COAD - Colon adenocarcinoma(1;0.188)|Colorectal(1;0.202)			CCTGGATGTTGACTGCCTTGA	0.463000			A		serous ovarian								5	160					0	0	1	0	0
DNM1P47	0	broad.mit.edu	37	15	102292820	102292820	+	RNA	SNP	G	G	C			TCGA-DH-A7UR-01A-11D-A33T-08	TCGA-DH-A7UR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f04342d6-2f32-40ec-a731-3e7bd18ffffe	bfcd7244-5a98-40a6-9328-e7fe970754e9	g.chr15:102292820G>C	ENST00000561463.1	+	0	866																		p.T136T(2)									GCGTGGGAACGAGAAGACACT	0.592000													4	53					0	0	1	0	0
AHNAK2	113146	broad.mit.edu	37	14	105408233	105408233	+	Missense_Mutation	SNP	C	C	T			TCGA-DH-A7UR-01A-11D-A33T-08	TCGA-DH-A7UR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f04342d6-2f32-40ec-a731-3e7bd18ffffe	bfcd7244-5a98-40a6-9328-e7fe970754e9	g.chr14:105408233C>T	ENST00000333244.5	-	7	13674	c.13555G>A	c.(13555-13557)Gac>Aac	p.D4519N	AHNAK2_ENST00000557457.1_Intron	NM_138420.2	NP_612429.2	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	4519						nucleus				cervix(4)|endometrium(4)|large_intestine(3)|lung(14)|ovary(2)|prostate(2)|skin(1)|stomach(3)	33		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			ACCTCCAGGTCGGCGGAAGGG	0.627000													6	323					0	0	1	0	0
CENPBD1	92806	broad.mit.edu	37	16	90038172	90038172	+	Silent	SNP	T	T	C			TCGA-DH-A7UR-01A-11D-A33T-08	TCGA-DH-A7UR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f04342d6-2f32-40ec-a731-3e7bd18ffffe	bfcd7244-5a98-40a6-9328-e7fe970754e9	g.chr16:90038172T>C	ENST00000314994.3	-	1	770	c.159A>G	c.(157-159)acA>acG	p.T53T	RP11-566K11.5_ENST00000565150.1_RNA|CENPBD1_ENST00000567035.1_Intron	NM_145039.3	NP_659476.2	B2RD01	CENP1_HUMAN	CENPB DNA-binding domains containing 1	53	HTH psq-type.				regulation of transcription, DNA-dependent	chromosome, centromeric region|nucleus	DNA binding			endometrium(1)|lung(2)	3						TGGTCGCCACTGTAGAGATAG	0.463000													23	45					0	0	1	0	0
FBN3	84467	broad.mit.edu	37	19	8161785	8161785	+	Missense_Mutation	SNP	G	G	A			TCGA-DH-A7UR-01A-11D-A33T-08	TCGA-DH-A7UR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f04342d6-2f32-40ec-a731-3e7bd18ffffe	bfcd7244-5a98-40a6-9328-e7fe970754e9	g.chr19:8161785G>A	ENST00000600128.1	-	43	5807	c.5393C>T	c.(5392-5394)tCg>tTg	p.S1798L	FBN3_ENST00000601739.1_Missense_Mutation_p.S1798L|FBN3_ENST00000270509.2_Missense_Mutation_p.S1798L			Q75N90	FBN3_HUMAN	fibrillin 3	1798	EGF-like 27; calcium-binding.					proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			NS(1)|breast(9)|central_nervous_system(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(15)|lung(53)|ovary(7)|pancreas(2)|prostate(3)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	132						CCCGCCTGGCGACAGTTTGTA	0.617000													54	112					0	0	1	0	0
L1CAM	3897	broad.mit.edu	37	X	153135292	153135292	+	Missense_Mutation	SNP	C	C	A			TCGA-DH-A7UR-01A-11D-A33T-08	TCGA-DH-A7UR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f04342d6-2f32-40ec-a731-3e7bd18ffffe	bfcd7244-5a98-40a6-9328-e7fe970754e9	g.chrX:153135292C>A	ENST00000370060.1	-	10	1278	c.1089G>T	c.(1087-1089)gaG>gaT	p.E363D	L1CAM_ENST00000370057.3_Missense_Mutation_p.E363D|L1CAM_ENST00000361981.3_Missense_Mutation_p.E358D|L1CAM_ENST00000361699.4_Missense_Mutation_p.E363D|L1CAM_ENST00000543994.1_Missense_Mutation_p.E365D|L1CAM_ENST00000538883.1_Missense_Mutation_p.E365D|L1CAM_ENST00000370055.1_Missense_Mutation_p.E358D	NM_001278116.1	NP_001265045.1	P32004	L1CAM_HUMAN	L1 cell adhesion molecule	363	Ig-like C2-type 4.				axon guidance|blood coagulation|cell death|leukocyte migration	integral to membrane				NS(1)|breast(4)|central_nervous_system(3)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(5)|liver(1)|lung(31)|ovary(13)|pancreas(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	81	all_cancers(53;6.72e-15)|all_epithelial(53;3.19e-09)|all_lung(58;3.39e-06)|all_hematologic(71;4.25e-06)|Lung NSC(58;4.7e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					TCCAGGTGACCTCTGGTTGGG	0.657000													6	48					0.00116845	0.00119092	1	1	0
NOS1	4842	broad.mit.edu	37	12	117691483	117691483	+	Missense_Mutation	SNP	T	T	C			TCGA-DH-A7UR-01A-11D-A33T-08	TCGA-DH-A7UR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f04342d6-2f32-40ec-a731-3e7bd18ffffe	bfcd7244-5a98-40a6-9328-e7fe970754e9	g.chr12:117691483T>C	ENST00000317775.6	-	17	3293	c.2608A>G	c.(2608-2610)Aga>Gga	p.R870G	NOS1_ENST00000338101.4_Missense_Mutation_p.R904G|NOS1_ENST00000344089.3_3'UTR	NM_000620.4|NM_001204218.1	NP_000611.1|NP_001191147.1	P29475	NOS1_HUMAN	nitric oxide synthase 1 (neuronal)	870	Flavodoxin-like.				multicellular organismal response to stress|myoblast fusion|negative regulation of calcium ion transport into cytosol|neurotransmitter biosynthetic process|nitric oxide biosynthetic process|platelet activation|positive regulation of vasodilation|regulation of cardiac muscle contraction|response to heat|response to hypoxia	cytoskeleton|cytosol|dendritic spine|perinuclear region of cytoplasm|photoreceptor inner segment|sarcolemma|sarcoplasmic reticulum	arginine binding|cadmium ion binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|tetrahydrobiopterin binding			NS(1)|breast(1)|central_nervous_system(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(17)|large_intestine(21)|lung(43)|ovary(3)|pancreas(1)|prostate(6)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	117	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.0561)	L-Citrulline(DB00155)	AAGTTGTCTCTGAGGTCGGGC	0.557000													10	137					0	0	1	0	0
TTC7A	57217	broad.mit.edu	37	2	47221500	47221500	+	Missense_Mutation	SNP	C	C	T			TCGA-DH-A7UR-01A-11D-A33T-08	TCGA-DH-A7UR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f04342d6-2f32-40ec-a731-3e7bd18ffffe	bfcd7244-5a98-40a6-9328-e7fe970754e9	g.chr2:47221500C>T	ENST00000319190.5	+	7	1216	c.848C>T	c.(847-849)gCg>gTg	p.A283V	TTC7A_ENST00000409245.1_Missense_Mutation_p.A249V|TTC7A_ENST00000394850.2_Missense_Mutation_p.A283V|TTC7A_ENST00000263737.6_Intron|TTC7A_ENST00000461601.1_3'UTR	NM_020458.2	NP_065191.2	Q9ULT0	TTC7A_HUMAN	tetratricopeptide repeat domain 7A	283							binding			breast(4)|endometrium(3)|kidney(2)|large_intestine(4)|lung(8)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	25		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.18)	Lung(47;0.0792)|LUSC - Lung squamous cell carcinoma(58;0.114)			TGCCAGATGGCGGCCAAGCAC	0.632000													14	294					0	0	1	0	0
OR14C36	127066	broad.mit.edu	37	1	248512274	248512274	+	Missense_Mutation	SNP	C	C	G			TCGA-DH-A7UR-01A-11D-A33T-08	TCGA-DH-A7UR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f04342d6-2f32-40ec-a731-3e7bd18ffffe	bfcd7244-5a98-40a6-9328-e7fe970754e9	g.chr1:248512274C>G	ENST00000317861.1	+	1	198	c.198C>G	c.(196-198)atC>atG	p.I66M		NM_001001918.1	NP_001001918.1	Q8NHC7	O14CZ_HUMAN	olfactory receptor, family 14, subfamily C, member 36	66					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(2)|large_intestine(4)|liver(2)|lung(20)|ovary(2)|prostate(3)|skin(7)|upper_aerodigestive_tract(2)	43						ATCTGTCTATCTTGGATGCCT	0.478000													5	152					0	0	1	0	0
OR2A5	393046	broad.mit.edu	37	7	143748408	143748408	+	Missense_Mutation	SNP	T	T	G			TCGA-DH-A7UR-01A-11D-A33T-08	TCGA-DH-A7UR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f04342d6-2f32-40ec-a731-3e7bd18ffffe	bfcd7244-5a98-40a6-9328-e7fe970754e9	g.chr7:143748408T>G	ENST00000408906.2	+	1	948	c.914T>G	c.(913-915)tTg>tGg	p.L305W		NM_012365.1	NP_036497.1	Q96R48	OR2A5_HUMAN	olfactory receptor, family 2, subfamily A, member 5	305					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|endometrium(3)|large_intestine(5)|lung(23)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	38	Melanoma(164;0.0783)					AAAAGAGTGTTGTGGAAACAG	0.473000													8	136					0	0	1	0	0
KIF20B	9585	broad.mit.edu	37	10	91465121	91465121	+	Missense_Mutation	SNP	A	A	G			TCGA-DH-A7UR-01A-11D-A33T-08	TCGA-DH-A7UR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f04342d6-2f32-40ec-a731-3e7bd18ffffe	bfcd7244-5a98-40a6-9328-e7fe970754e9	g.chr10:91465121A>G	ENST00000416354.1	+	2	142	c.70A>G	c.(70-72)Agg>Ggg	p.R24G	KIF20B_ENST00000371728.3_Missense_Mutation_p.R24G|KIF20B_ENST00000260753.4_Missense_Mutation_p.R24G|KIF20B_ENST00000394289.2_Missense_Mutation_p.R24G			Q96Q89	KI20B_HUMAN	kinesin family member 20B	24					cell cycle arrest|cell division|microtubule-based movement|mitosis|regulation of mitosis	centrosome|microtubule|nucleolus|nucleoplasm|spindle	ATP binding|ATPase activity|microtubule motor activity|WW domain binding			endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(20)|lung(15)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)	58						CCCAATTGCAAGGCCTTCAGA	0.358000													58	114					0	0	1	0	0
ACSL6	23305	broad.mit.edu	37	5	131321132	131321132	+	Missense_Mutation	SNP	A	A	C			TCGA-DH-A7UR-01A-11D-A33T-08	TCGA-DH-A7UR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f04342d6-2f32-40ec-a731-3e7bd18ffffe	bfcd7244-5a98-40a6-9328-e7fe970754e9	g.chr5:131321132A>C	ENST00000379264.2	-	9	992	c.884T>G	c.(883-885)cTc>cGc	p.L295R	ACSL6_ENST00000544770.1_Missense_Mutation_p.L179R|ACSL6_ENST00000379272.2_Missense_Mutation_p.L285R|ACSL6_ENST00000296869.4_Missense_Mutation_p.L295R|ACSL6_ENST00000379240.1_Missense_Mutation_p.L270R|ACSL6_ENST00000379255.1_Missense_Mutation_p.L235R|ACSL6_ENST00000379249.3_Missense_Mutation_p.L270R|ACSL6_ENST00000357096.1_Missense_Mutation_p.L235R|ACSL6_ENST00000431707.1_Missense_Mutation_p.L250R|ACSL6_ENST00000379246.1_Missense_Mutation_p.L281R|ACSL6_ENST00000543479.1_Missense_Mutation_p.L270R|ACSL6_ENST00000379244.1_Missense_Mutation_p.L270R	NM_001009185.2	NP_001009185.1	Q9UKU0	ACSL6_HUMAN	acyl-CoA synthetase long-chain family member 6	270					fatty acid metabolic process|long-chain fatty-acyl-CoA biosynthetic process|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane|microsome|mitochondrial outer membrane|peroxisomal membrane|plasma membrane	ATP binding|long-chain fatty acid-CoA ligase activity			NS(1)|breast(1)|endometrium(2)|kidney(4)|large_intestine(8)|lung(12)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	35		all_cancers(142;0.107)|Breast(839;0.198)|Lung NSC(810;0.216)|all_lung(232;0.248)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			CACAATGGAGAGGTCATCAGG	0.627000													9	41					0	0	1	0	0
ADAMTS12	81792	broad.mit.edu	37	5	33588803	33588803	+	Silent	SNP	C	C	T			TCGA-DH-A7UR-01A-11D-A33T-08	TCGA-DH-A7UR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f04342d6-2f32-40ec-a731-3e7bd18ffffe	bfcd7244-5a98-40a6-9328-e7fe970754e9	g.chr5:33588803C>T	ENST00000504830.1	-	18	3101	c.2766G>A	c.(2764-2766)ccG>ccA	p.P922P	ADAMTS12_ENST00000504582.1_5'UTR|ADAMTS12_ENST00000352040.3_Silent_p.P837P	NM_030955.2	NP_112217.2	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 12	922	TSP type-1 3.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding	p.P922P(1)		NS(1)|breast(7)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(11)|large_intestine(31)|liver(1)|lung(135)|ovary(4)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(5)	216						AGTCTGTGGGCGGGAGAGCCT	0.632000										HNSCC(64;0.19)			77	90					0	0	1	0	0
HELZ2	85441	broad.mit.edu	37	20	62196935	62196935	+	Silent	SNP	G	G	A			TCGA-DH-A7UR-01A-11D-A33T-08	TCGA-DH-A7UR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f04342d6-2f32-40ec-a731-3e7bd18ffffe	bfcd7244-5a98-40a6-9328-e7fe970754e9	g.chr20:62196935G>A	ENST00000467148.1	-	8	3309	c.3240C>T	c.(3238-3240)gaC>gaT	p.D1080D	HELZ2_ENST00000427522.2_Silent_p.D511D	NM_001037335.2	NP_001032412.2			helicase with zinc finger 2, transcriptional coactivator																		TCTGGCTCTCGTCCAGAAGCT	0.672000													4	45					0	0	1	0	0
ANKRD32	84250	broad.mit.edu	37	5	94014527	94014527	+	Silent	SNP	A	A	G			TCGA-DH-A7UR-01A-11D-A33T-08	TCGA-DH-A7UR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f04342d6-2f32-40ec-a731-3e7bd18ffffe	bfcd7244-5a98-40a6-9328-e7fe970754e9	g.chr5:94014527A>G	ENST00000265140.5	+	15	2261	c.1842A>G	c.(1840-1842)gaA>gaG	p.E614E		NM_032290.3	NP_115666.2	Q9BQI6	ANR32_HUMAN	ankyrin repeat domain 32	614										NS(1)|breast(2)|endometrium(2)|large_intestine(1)|lung(3)|ovary(2)|prostate(1)|skin(1)	13		all_cancers(142;1.51e-09)|all_epithelial(76;4.68e-12)|all_lung(232;5.94e-05)|Ovarian(174;0.000953)|Lung NSC(167;0.00105)|Colorectal(57;0.122)|Lung SC(612;0.152)		all cancers(79;3.88e-18)		TCAAACATGAACTAGCTTACT	0.313000													46	60					0	0	1	0	0
FAM13C	220965	broad.mit.edu	37	10	61012753	61012753	+	Silent	SNP	C	C	T			TCGA-DH-A7UR-01A-11D-A33T-08	TCGA-DH-A7UR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f04342d6-2f32-40ec-a731-3e7bd18ffffe	bfcd7244-5a98-40a6-9328-e7fe970754e9	g.chr10:61012753C>T	ENST00000373867.3	-	13	1551	c.1086G>A	c.(1084-1086)gaG>gaA	p.E362E	FAM13C_ENST00000373868.2_Silent_p.E446E|FAM13C_ENST00000277705.6_Silent_p.E466E|FAM13C_ENST00000435852.2_Silent_p.E446E|FAM13C_ENST00000468840.2_Silent_p.E363E|FAM13C_ENST00000419214.2_Silent_p.E348E|FAM13C_ENST00000442566.3_Silent_p.E467E	NM_001166698.1	NP_001160170.1	Q8NE31	FA13C_HUMAN	family with sequence similarity 13, member C	446										NS(1)|breast(2)|endometrium(3)|kidney(2)|large_intestine(8)|lung(19)|ovary(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	45						AGTCCTCTTCCTCCTGCTTAT	0.463000													6	87					0	0	1	0	0
FES	2242	broad.mit.edu	37	15	91428384	91428384	+	Missense_Mutation	SNP	C	C	T			TCGA-DH-A7UR-01A-11D-A33T-08	TCGA-DH-A7UR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f04342d6-2f32-40ec-a731-3e7bd18ffffe	bfcd7244-5a98-40a6-9328-e7fe970754e9	g.chr15:91428384C>T	ENST00000328850.3	+	2	251	c.109C>T	c.(109-111)Cgg>Tgg	p.R37W	FES_ENST00000450438.2_Missense_Mutation_p.R37W|FES_ENST00000414248.2_Missense_Mutation_p.R37W|FES_ENST00000394300.3_Missense_Mutation_p.R37W|FES_ENST00000394302.1_Missense_Mutation_p.R37W|FES_ENST00000444422.2_Missense_Mutation_p.R37W	NM_002005.3	NP_001996.1	P07332	FES_HUMAN	feline sarcoma oncogene	37	FCH.|Important for interaction with membranes containing phosphoinositides.				axon guidance|cell proliferation|peptidyl-tyrosine phosphorylation	cytosol	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding			lung(2)|ovary(1)	3	Lung NSC(78;0.0771)|all_lung(78;0.137)		Lung(145;0.229)			GATGGCCCAGCGGGTCAAGAG	0.637000													4	245					0	0	1	0	0
MYH3	4621	broad.mit.edu	37	17	10547674	10547674	+	Silent	SNP	G	G	A			TCGA-DH-A7UR-01A-11D-A33T-08	TCGA-DH-A7UR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f04342d6-2f32-40ec-a731-3e7bd18ffffe	bfcd7244-5a98-40a6-9328-e7fe970754e9	g.chr17:10547674G>A	ENST00000583535.1	-	14	1491	c.1404C>T	c.(1402-1404)atC>atT	p.I468I	MYH3_ENST00000226209.7_Silent_p.I468I	NM_002470.3	NP_002461.2	P11055	MYH3_HUMAN	myosin, heavy chain 3, skeletal muscle, embryonic	468	Myosin head-like.				muscle filament sliding|muscle organ development	cytosol|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(8)|kidney(5)|large_intestine(18)|lung(30)|ovary(4)|pancreas(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(5)|urinary_tract(1)	83						AAACCTCAAAGATTTCAAAGC	0.403000													36	111					0	0	1	0	0
NCOA1	8648	broad.mit.edu	37	2	24952522	24952522	+	Silent	SNP	G	G	A			TCGA-DH-A7UR-01A-11D-A33T-08	TCGA-DH-A7UR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f04342d6-2f32-40ec-a731-3e7bd18ffffe	bfcd7244-5a98-40a6-9328-e7fe970754e9	g.chr2:24952522G>A	ENST00000405141.1	+	18	3750	c.3039G>A	c.(3037-3039)agG>agA	p.R1013R	NCOA1_ENST00000538539.1_Silent_p.R1013R|NCOA1_ENST00000395856.3_Silent_p.R1013R|NCOA1_ENST00000407230.1_Silent_p.R862R|NCOA1_ENST00000406961.1_Silent_p.R1013R|NCOA1_ENST00000288599.5_Silent_p.R1013R|NCOA1_ENST00000348332.3_Silent_p.R1013R			Q15788	NCOA1_HUMAN	nuclear receptor coactivator 1	1013									PAX3/NCOA1(8)	breast(3)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(13)|lung(26)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	53	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GCATGGTCAGGCAAAAACCTT	0.512000			T	PAX3	alveolar rhadomyosarcoma								4	217					0	0	1	0	0
PDC	5132	broad.mit.edu	37	1	186413580	186413580	+	Missense_Mutation	SNP	C	C	T			TCGA-DH-A7UR-01A-11D-A33T-08	TCGA-DH-A7UR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f04342d6-2f32-40ec-a731-3e7bd18ffffe	bfcd7244-5a98-40a6-9328-e7fe970754e9	g.chr1:186413580C>T	ENST00000391997.2	-	4	359	c.272G>A	c.(271-273)cGt>cAt	p.R91H	PDC_ENST00000340129.5_Missense_Mutation_p.R91H|PDC_ENST00000456239.2_Missense_Mutation_p.R39H|PDC_ENST00000497198.1_Missense_Mutation_p.R39H	NM_002597.4	NP_002588.3	P20941	PHOS_HUMAN	phosducin	91					G-protein coupled receptor protein signaling pathway|phototransduction|visual perception	actin cytoskeleton|cytosol|nucleus|photoreceptor inner segment|photoreceptor outer segment	phospholipase inhibitor activity			central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(1)|prostate(1)|skin(1)	7		Breast(1374;1.53e-05)		KIRC - Kidney renal clear cell carcinoma(1967;3.23e-08)|Colorectal(1306;0.0129)		ACGGTATTTACGAAGGCAGTT	0.368000													53	106					0	0	1	0	0
SKIDA1	387640	broad.mit.edu	37	10	21804129	21804129	+	Missense_Mutation	SNP	C	C	A			TCGA-DH-A7UR-01A-11D-A33T-08	TCGA-DH-A7UR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f04342d6-2f32-40ec-a731-3e7bd18ffffe	bfcd7244-5a98-40a6-9328-e7fe970754e9	g.chr10:21804129C>A	ENST00000449193.2	-	4	4875	c.2623G>T	c.(2623-2625)Gat>Tat	p.D875Y	SKIDA1_ENST00000444772.3_Missense_Mutation_p.D796Y	NM_207371.3	NP_997254.3			SKI/DACH domain containing 1																		GTTTGAGAATCCTTAGTGGTG	0.443000													21	37					3.62473e-10	3.73031e-10	1	1	0
ELF1	1997	broad.mit.edu	37	13	41556170	41556170	+	Missense_Mutation	SNP	C	C	G			TCGA-DH-A7UR-01A-11D-A33T-08	TCGA-DH-A7UR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f04342d6-2f32-40ec-a731-3e7bd18ffffe	bfcd7244-5a98-40a6-9328-e7fe970754e9	g.chr13:41556170C>G	ENST00000239882.3	-	2	335	c.21G>C	c.(19-21)caG>caC	p.Q7H	ELF1_ENST00000442101.1_Missense_Mutation_p.Q7H|ELF1_ENST00000498824.1_5'UTR	NM_172373.3	NP_758961.1	P32519	ELF1_HUMAN	E74-like factor 1 (ets domain transcription factor)	7					positive regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(8)|lung(12)|ovary(1)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	37		Lung NSC(96;8.3e-05)|Prostate(109;0.0233)|Breast(139;0.0296)|Lung SC(185;0.0367)		all cancers(112;1.87e-08)|Epithelial(112;8.45e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000202)|GBM - Glioblastoma multiforme(144;0.00266)|BRCA - Breast invasive adenocarcinoma(63;0.072)		CTAGGTCGTTCTGTTGGACAA	0.363000													54	97					0	0	1	0	0
ZNF326	284695	broad.mit.edu	37	1	90482967	90482967	+	Missense_Mutation	SNP	T	T	G			TCGA-DH-A7UR-01A-11D-A33T-08	TCGA-DH-A7UR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f04342d6-2f32-40ec-a731-3e7bd18ffffe	bfcd7244-5a98-40a6-9328-e7fe970754e9	g.chr1:90482967T>G	ENST00000340281.4	+	8	1161	c.1018T>G	c.(1018-1020)Tta>Gta	p.L340V	ZNF326_ENST00000370447.2_Missense_Mutation_p.L251V|ZNF326_ENST00000455342.2_Missense_Mutation_p.L134V	NM_182976.2	NP_892021.1	Q5BKZ1	ZN326_HUMAN	zinc finger protein 326	340					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear matrix	DNA binding	p.L340V(1)		central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(12)|lung(7)|ovary(1)	25		all_lung(203;0.0116)|Lung NSC(277;0.0417)		all cancers(265;0.00728)|Epithelial(280;0.0265)		TCAGGAAACATTAGATCATAT	0.299000													3	47					0	0	1	0	0
QRICH2	84074	broad.mit.edu	37	17	74277003	74277003	+	Missense_Mutation	SNP	G	G	A			TCGA-DH-A7UR-01A-11D-A33T-08	TCGA-DH-A7UR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f04342d6-2f32-40ec-a731-3e7bd18ffffe	bfcd7244-5a98-40a6-9328-e7fe970754e9	g.chr17:74277003G>A	ENST00000262765.5	-	9	3976	c.3797C>T	c.(3796-3798)gCc>gTc	p.A1266V		NM_032134.1	NP_115510.1	Q9H0J4	QRIC2_HUMAN	glutamine rich 2	1266							protein binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(6)|lung(17)|ovary(4)|pancreas(2)|prostate(3)|skin(2)|stomach(4)	62						CTGCAGGATGGCACTCTGCAC	0.617000													4	87					0	0	1	0	0
CIC	23152	broad.mit.edu	37	19	42797278	42797278	+	Nonsense_Mutation	SNP	C	C	T			TCGA-DH-A7UR-01A-11D-A33T-08	TCGA-DH-A7UR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f04342d6-2f32-40ec-a731-3e7bd18ffffe	bfcd7244-5a98-40a6-9328-e7fe970754e9	g.chr19:42797278C>T	ENST00000572681.2	+	16	6429	c.6361C>T	c.(6361-6363)Cga>Tga	p.R2121*	CIC_ENST00000160740.3_Nonsense_Mutation_p.R1212*|CIC_ENST00000575354.2_Nonsense_Mutation_p.R1214*			Q96RK0	CIC_HUMAN	capicua transcriptional repressor	1214					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding			autonomic_ganglia(1)|breast(5)|central_nervous_system(32)|endometrium(10)|kidney(2)|large_intestine(7)|lung(9)|ovary(7)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	82		Prostate(69;0.00682)				TGGCCCAGTCCGAGAGCCAAC	0.706000			"""Mis, F, S"""		oligodendroglioma								8	9					0	0	1	0	0
FAM120C	54954	broad.mit.edu	37	X	54161406	54161406	+	Missense_Mutation	SNP	A	A	C			TCGA-DH-A7UR-01A-11D-A33T-08	TCGA-DH-A7UR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f04342d6-2f32-40ec-a731-3e7bd18ffffe	bfcd7244-5a98-40a6-9328-e7fe970754e9	g.chrX:54161406A>C	ENST00000375180.2	-	7	1530	c.1474T>G	c.(1474-1476)Ttt>Gtt	p.F492V	FAM120C_ENST00000328235.4_Missense_Mutation_p.F492V	NM_017848.4	NP_060318.3	Q9NX05	F120C_HUMAN	family with sequence similarity 120C	492										breast(3)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(9)|ovary(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	28						CAATTGGCAAAGGGGCTGTTC	0.522000													24	62					0	0	1	0	0
MRGPRD	116512	broad.mit.edu	37	11	68747839	68747839	+	Missense_Mutation	SNP	C	C	T			TCGA-DH-A7UR-01A-11D-A33T-08	TCGA-DH-A7UR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f04342d6-2f32-40ec-a731-3e7bd18ffffe	bfcd7244-5a98-40a6-9328-e7fe970754e9	g.chr11:68747839C>T	ENST00000309106.3	-	1	616	c.617G>A	c.(616-618)cGg>cAg	p.R206Q		NM_198923.2	NP_944605.2	Q8TDS7	MRGRD_HUMAN	MAS-related GPR, member D	206						integral to membrane|plasma membrane	G-protein coupled receptor activity	p.R206Q(1)		NS(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(7)|lung(7)|pancreas(1)|prostate(2)	22			STAD - Stomach adenocarcinoma(18;0.0208)|LUAD - Lung adenocarcinoma(13;0.0713)			GGAGCTCCTCCGCACCCAGAC	0.627000													5	74					0	0	1	0	0
SEMA6B	10501	broad.mit.edu	37	19	4544495	4544495	+	Silent	SNP	C	C	T			TCGA-DH-A7UR-01A-11D-A33T-08	TCGA-DH-A7UR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f04342d6-2f32-40ec-a731-3e7bd18ffffe	bfcd7244-5a98-40a6-9328-e7fe970754e9	g.chr19:4544495C>T	ENST00000586582.1	-	17	2095	c.1785G>A	c.(1783-1785)tcG>tcA	p.S595S	SEMA6B_ENST00000586965.1_Silent_p.S595S|SEMA6B_ENST00000301293.3_Silent_p.S595S	NM_032108.3	NP_115484.2	Q9H3T3	SEM6B_HUMAN	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B	595					cell differentiation|nervous system development	integral to membrane	receptor activity			breast(1)|central_nervous_system(2)|large_intestine(4)|lung(11)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	21		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0149)|STAD - Stomach adenocarcinoma(1328;0.18)		GCAGGTTCACCGACACCAGCC	0.736000													3	23					0	0	1	0	0
OR4C3	256144	broad.mit.edu	37	11	48346856	48346856	+	Missense_Mutation	SNP	T	T	C			TCGA-DH-A7UR-01A-11D-A33T-08	TCGA-DH-A7UR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f04342d6-2f32-40ec-a731-3e7bd18ffffe	bfcd7244-5a98-40a6-9328-e7fe970754e9	g.chr11:48346856T>C	ENST00000319856.4	+	1	385	c.364T>C	c.(364-366)Tgc>Cgc	p.C122R		NM_001004702.1	NP_001004702.1	Q8NH37	OR4C3_HUMAN	olfactory receptor, family 4, subfamily C, member 3	95					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(18)|prostate(1)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)	32						TTATGAGTGCTGCATGGCTCA	0.458000													9	496					0	0	1	0	0
CCDC160	347475	broad.mit.edu	37	X	133379730	133379730	+	Missense_Mutation	SNP	G	G	T			TCGA-DH-A7UR-01A-11D-A33T-08	TCGA-DH-A7UR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f04342d6-2f32-40ec-a731-3e7bd18ffffe	bfcd7244-5a98-40a6-9328-e7fe970754e9	g.chrX:133379730G>T	ENST00000517294.1	+	3	1283	c.900G>T	c.(898-900)gaG>gaT	p.E300D	CCDC160_ENST00000370809.4_Missense_Mutation_p.E300D			A6NGH7	CC160_HUMAN	coiled-coil domain containing 160	300										endometrium(1)|kidney(2)|large_intestine(10)|lung(2)|prostate(1)|skin(1)	17						GAGCCTTGGAGTTGCTTAGAA	0.373000													3	32					1	1	1	1	0
ANO9	338440	broad.mit.edu	37	11	418476	418476	+	Nonsense_Mutation	SNP	C	C	T			TCGA-DH-A7UR-01A-11D-A33T-08	TCGA-DH-A7UR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f04342d6-2f32-40ec-a731-3e7bd18ffffe	bfcd7244-5a98-40a6-9328-e7fe970754e9	g.chr11:418476C>T	ENST00000332826.6	-	23	2328	c.2244G>A	c.(2242-2244)tgG>tgA	p.W748*		NM_001012302.2	NP_001012302.2	A1A5B4	ANO9_HUMAN	anoctamin 9	748						chloride channel complex	chloride channel activity			central_nervous_system(2)|cervix(1)|endometrium(3)|kidney(1)|lung(5)|ovary(1)|prostate(4)|skin(4)	21						GCCTTCCATGCCACATCTTCT	0.622000													45	88					0	0	1	0	0
TLE4	7091	broad.mit.edu	37	9	82323125	82323125	+	Missense_Mutation	SNP	G	G	T			TCGA-DH-A7UR-01A-11D-A33T-08	TCGA-DH-A7UR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f04342d6-2f32-40ec-a731-3e7bd18ffffe	bfcd7244-5a98-40a6-9328-e7fe970754e9	g.chr9:82323125G>T	ENST00000376520.4	+	13	1953	c.1125G>T	c.(1123-1125)ttG>ttT	p.L375F	TLE4_ENST00000376537.4_Missense_Mutation_p.L375F|TLE4_ENST00000376534.4_5'UTR|TLE4_ENST00000376544.3_Missense_Mutation_p.L274F|TLE4_ENST00000376552.2_Missense_Mutation_p.L343F|TLE4_ENST00000265284.6_Missense_Mutation_p.L318F			O60756	BCE1_HUMAN	transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)	0								p.L375L(1)|p.L343L(1)		breast(2)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(10)|lung(12)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	39						CTCCCGGATTGAGGCCTGTAC	0.418000													15	171					6.81908e-15	7.22822e-15	1	1	0
RP11-156P1.3	0	broad.mit.edu	37	17	45128792	45128792	+	RNA	SNP	G	G	T	rs143713325	by1000genomes	TCGA-DH-A7UR-01A-11D-A33T-08	TCGA-DH-A7UR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f04342d6-2f32-40ec-a731-3e7bd18ffffe	bfcd7244-5a98-40a6-9328-e7fe970754e9	g.chr17:45128792G>T	ENST00000575173.1	-	0	418																											AATTCAGGTTGTCAGAATGCA	0.373000													4	109					0.00909568	0.00918231	1	1	0
PTCHD1	139411	broad.mit.edu	37	X	23398283	23398283	+	Silent	SNP	G	G	A			TCGA-DH-A7UR-01A-11D-A33T-08	TCGA-DH-A7UR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f04342d6-2f32-40ec-a731-3e7bd18ffffe	bfcd7244-5a98-40a6-9328-e7fe970754e9	g.chrX:23398283G>A	ENST00000379361.4	+	2	1787	c.927G>A	c.(925-927)ctG>ctA	p.L309L		NM_173495.2	NP_775766.2	Q96NR3	PTHD1_HUMAN	patched domain containing 1	309	SSD.				cognition|smoothened signaling pathway	integral to membrane|plasma membrane	hedgehog receptor activity			NS(1)|breast(4)|endometrium(3)|kidney(3)|large_intestine(9)|lung(14)|ovary(4)|skin(2)|urinary_tract(2)	42						CCATAAGCCTGGCCACTCTCA	0.517000													71	155					0	0	1	0	0
PPP1R26	9858	broad.mit.edu	37	9	138378891	138378891	+	Silent	SNP	G	G	A			TCGA-DH-A7UR-01A-11D-A33T-08	TCGA-DH-A7UR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f04342d6-2f32-40ec-a731-3e7bd18ffffe	bfcd7244-5a98-40a6-9328-e7fe970754e9	g.chr9:138378891G>A	ENST00000356818.2	+	4	3084	c.2535G>A	c.(2533-2535)ttG>ttA	p.L845L	PPP1R26_ENST00000605660.1_Silent_p.L845L|PPP1R26_ENST00000401470.3_Silent_p.L845L|PPP1R26_ENST00000605286.1_Silent_p.L845L|PPP1R26_ENST00000604351.1_Silent_p.L845L|PPP1R26_ENST00000602993.1_Intron	NM_014811.3	NP_055626.3	Q5T8A7	K0649_HUMAN	protein phosphatase 1, regulatory subunit 26	845						nucleolus	protein binding										GGAAGTTTTTGGCGGAAAAGG	0.612000													4	228					0	0	1	0	0
EHBP1	23301	broad.mit.edu	37	2	63272232	63272232	+	Silent	SNP	C	C	T			TCGA-DH-A7UR-01A-11D-A33T-08	TCGA-DH-A7UR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f04342d6-2f32-40ec-a731-3e7bd18ffffe	bfcd7244-5a98-40a6-9328-e7fe970754e9	g.chr2:63272232C>T	ENST00000263991.5	+	24	4004	c.3522C>T	c.(3520-3522)cgC>cgT	p.R1174R	EHBP1_ENST00000354487.3_Silent_p.R1139R|EHBP1_ENST00000405289.1_Silent_p.R1139R|AC009501.4_ENST00000437346.1_RNA|EHBP1_ENST00000496857.1_3'UTR|EHBP1_ENST00000431489.1_Silent_p.R1103R|AC009501.4_ENST00000429952.1_RNA|EHBP1_ENST00000405015.3_Silent_p.R1103R	NM_015252.3	NP_056067.2	Q8NDI1	EHBP1_HUMAN	EH domain binding protein 1	1174						cytoplasm|membrane				biliary_tract(1)|breast(3)|cervix(1)|endometrium(4)|kidney(4)|large_intestine(8)|lung(22)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	47	Lung NSC(7;0.0951)|all_lung(7;0.169)		LUSC - Lung squamous cell carcinoma(7;7.74e-05)|Epithelial(17;0.189)			AGAAGCGACGCGAACAGCTTC	0.662000													6	11					0	0	1	0	0
MLLT3	4300	broad.mit.edu	37	9	20414298	20414298	+	Silent	SNP	A	A	G	rs143254940	byFrequency	TCGA-DH-A7UR-01A-11D-A33T-08	TCGA-DH-A7UR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f04342d6-2f32-40ec-a731-3e7bd18ffffe	bfcd7244-5a98-40a6-9328-e7fe970754e9	g.chr9:20414298A>G	ENST00000380338.4	-	5	832	c.546T>C	c.(544-546)agT>agC	p.S182S	MLLT3_ENST00000355930.6_5'UTR|MLLT3_ENST00000475957.1_5'UTR|MLLT3_ENST00000429426.2_Silent_p.S179S	NM_004529.2	NP_004520.2	P42568	AF9_HUMAN	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3	182	Poly-Ser.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding			central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(6)|lung(24)|ovary(1)|prostate(4)|skin(1)|urinary_tract(7)	66				GBM - Glioblastoma multiforme(3;4.35e-105)|Lung(42;3.48e-06)|LUSC - Lung squamous cell carcinoma(42;7.92e-05)		tgctgctgctactgctgctgc	0.522000			T	MLL	ALL								5	155					0	0	1	0	0
CRYBA1	1411	broad.mit.edu	37	17	27581333	27581333	+	Missense_Mutation	SNP	C	C	T	rs147836280		TCGA-DH-A7UR-01A-11D-A33T-08	TCGA-DH-A7UR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f04342d6-2f32-40ec-a731-3e7bd18ffffe	bfcd7244-5a98-40a6-9328-e7fe970754e9	g.chr17:27581333C>T	ENST00000225387.3	+	6	615	c.614C>T	c.(613-615)tCg>tTg	p.S205L		NM_005208.4	NP_005199.2	P05813	CRBA1_HUMAN	crystallin, beta A1	205	Beta/gamma crystallin 'Greek key' 4.				visual perception	soluble fraction	structural constituent of eye lens			breast(1)|large_intestine(2)|lung(1)|prostate(1)	5			BRCA - Breast invasive adenocarcinoma(11;3.3e-05)|Colorectal(6;0.0178)|COAD - Colon adenocarcinoma(6;0.0551)			GCCCAGACTTCGCAGATCCAA	0.443000													16	236					0	0	1	0	0
N4BP2L2	10443	broad.mit.edu	37	13	33111032	33111032	+	Nonsense_Mutation	SNP	T	T	A			TCGA-DH-A7UR-01A-11D-A33T-08	TCGA-DH-A7UR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f04342d6-2f32-40ec-a731-3e7bd18ffffe	bfcd7244-5a98-40a6-9328-e7fe970754e9	g.chr13:33111032T>A	ENST00000267068.3	-	2	297	c.133A>T	c.(133-135)Aga>Tga	p.R45*	N4BP2L2_ENST00000357505.6_Intron|N4BP2L2_ENST00000399396.3_Intron|N4BP2L2_ENST00000504114.1_Intron|N4BP2L2_ENST00000446957.2_Nonsense_Mutation_p.R45*	NM_014887.2	NP_055702.1	Q92802	N42L2_HUMAN	NEDD4 binding protein 2-like 2	45										kidney(4)|large_intestine(3)|liver(1)|lung(6)|skin(1)|urinary_tract(1)	16		Lung SC(185;0.0262)		all cancers(112;9.5e-07)|Epithelial(112;5.07e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.00196)|BRCA - Breast invasive adenocarcinoma(63;0.00438)|GBM - Glioblastoma multiforme(144;0.243)		TCTTGGATTCTGTGAAAATCA	0.388000													55	100					0	0	1	0	0
PSMD2	5708	broad.mit.edu	37	3	184022109	184022109	+	Missense_Mutation	SNP	C	C	T			TCGA-DH-A7UR-01A-11D-A33T-08	TCGA-DH-A7UR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f04342d6-2f32-40ec-a731-3e7bd18ffffe	bfcd7244-5a98-40a6-9328-e7fe970754e9	g.chr3:184022109C>T	ENST00000310118.4	+	12	2027	c.1469C>T	c.(1468-1470)gCt>gTt	p.A490V	PSMD2_ENST00000439383.1_Missense_Mutation_p.A360V|PSMD2_ENST00000435761.1_Missense_Mutation_p.A331V|EIF2B5_ENST00000444495.1_Intron	NM_002808.3	NP_002799.3	Q13200	PSMD2_HUMAN	proteasome (prosome, macropain) 26S subunit, non-ATPase, 2	490					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|regulation of protein catabolic process|S phase of mitotic cell cycle|viral reproduction	proteasome regulatory particle	enzyme regulator activity|protein binding			breast(1)|central_nervous_system(1)|cervix(1)|kidney(1)|large_intestine(5)|liver(1)|lung(12)|prostate(3)|upper_aerodigestive_tract(2)	27	all_cancers(143;1.54e-10)|Ovarian(172;0.0339)		Epithelial(37;1.53e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)		Bortezomib(DB00188)	TTGGCTTATGCTGGCTCAAAT	0.478000													4	173					0	0	1	0	0
DNM1P47	0	broad.mit.edu	37	15	102292832	102292832	+	RNA	SNP	G	G	C			TCGA-DH-A7UR-01A-11D-A33T-08	TCGA-DH-A7UR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f04342d6-2f32-40ec-a731-3e7bd18ffffe	bfcd7244-5a98-40a6-9328-e7fe970754e9	g.chr15:102292832G>C	ENST00000561463.1	+	0	878																											GAAGACACTCGTGGAGGCGTC	0.597000													4	49					0	0	1	0	0
WDFY3	23001	broad.mit.edu	37	4	85634366	85634366	+	Missense_Mutation	SNP	G	G	A			TCGA-DH-A7UR-01A-11D-A33T-08	TCGA-DH-A7UR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f04342d6-2f32-40ec-a731-3e7bd18ffffe	bfcd7244-5a98-40a6-9328-e7fe970754e9	g.chr4:85634366G>A	ENST00000322366.6	-	50	8344	c.7937C>T	c.(7936-7938)aCg>aTg	p.T2646M	WDFY3_ENST00000295888.4_Missense_Mutation_p.T2663M			Q8IZQ1	WDFY3_HUMAN	WD repeat and FYVE domain containing 3	2663						cytoplasmic part|extrinsic to membrane|nuclear envelope	1-phosphatidylinositol binding|metal ion binding|protein binding			breast(5)|central_nervous_system(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(32)|lung(50)|ovary(3)|prostate(5)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	134		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000808)		TGAACTGTCCGTTAGAGATGG	0.423000													5	254					0	0	1	0	0
PCLO	27445	broad.mit.edu	37	7	82582077	82582077	+	Missense_Mutation	SNP	C	C	T			TCGA-DH-A7UR-01A-11D-A33T-08	TCGA-DH-A7UR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f04342d6-2f32-40ec-a731-3e7bd18ffffe	bfcd7244-5a98-40a6-9328-e7fe970754e9	g.chr7:82582077C>T	ENST00000423517.2	-	5	8529	c.8192G>A	c.(8191-8193)cGt>cAt	p.R2731H	PCLO_ENST00000333891.8_Missense_Mutation_p.R2731H	NM_014510.2	NP_055325.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein	2662					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						TGGTACTGTACGCAAATCAAT	0.353000													9	64					0	0	1	0	0
NIT2	56954	broad.mit.edu	37	3	100065063	100065063	+	Missense_Mutation	SNP	C	C	T			TCGA-DH-A7UR-01A-11D-A33T-08	TCGA-DH-A7UR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f04342d6-2f32-40ec-a731-3e7bd18ffffe	bfcd7244-5a98-40a6-9328-e7fe970754e9	g.chr3:100065063C>T	ENST00000394140.3	+	6	560	c.469C>T	c.(469-471)Cgg>Tgg	p.R157W		NM_020202.4	NP_064587.1	Q9NQR4	NIT2_HUMAN	nitrilase family, member 2	157	CN hydrolase.				nitrogen compound metabolic process		omega-amidase activity			breast(1)|endometrium(1)|kidney(4)|large_intestine(3)|lung(4)|ovary(1)|prostate(2)|skin(1)	17						CTACGACATGCGGTTTGCAGA	0.493000													3	63					0	0	1	0	0
BAI1	575	broad.mit.edu	37	8	143604041	143604041	+	Missense_Mutation	SNP	C	C	T			TCGA-DH-A7UR-01A-11D-A33T-08	TCGA-DH-A7UR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f04342d6-2f32-40ec-a731-3e7bd18ffffe	bfcd7244-5a98-40a6-9328-e7fe970754e9	g.chr8:143604041C>T	ENST00000517894.1	+	22	4109	c.3215C>T	c.(3214-3216)aCc>aTc	p.T1072I	BAI1_ENST00000323289.5_Missense_Mutation_p.T1072I			O14514	BAI1_HUMAN	brain-specific angiogenesis inhibitor 1	1072					axonogenesis|cell adhesion|negative regulation of angiogenesis|negative regulation of cell proliferation|neuropeptide signaling pathway|peripheral nervous system development	cell-cell junction|integral to plasma membrane	G-protein coupled receptor activity|protein binding			NS(1)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(2)|lung(28)|ovary(4)|pancreas(1)|prostate(7)	57	all_cancers(97;2.84e-12)|all_epithelial(106;5.91e-09)|Lung NSC(106;0.000322)|all_lung(105;0.000616)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0315)|Acute lymphoblastic leukemia(118;0.155)					GTGGGATTCACCAAGGCCAAA	0.627000													7	8					0	0	1	0	0
GRIA3	2892	broad.mit.edu	37	X	122536950	122536950	+	Splice_Site	SNP	G	G	T			TCGA-DH-A7UR-01A-11D-A33T-08	TCGA-DH-A7UR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f04342d6-2f32-40ec-a731-3e7bd18ffffe	bfcd7244-5a98-40a6-9328-e7fe970754e9	g.chrX:122536950G>T	ENST00000264357.5	+	8	1477		c.e8+1		GRIA3_ENST00000542149.1_Splice_Site|GRIA3_ENST00000371251.1_Splice_Site|GRIA3_ENST00000541091.1_Splice_Site|GRIA3_ENST00000371256.5_Splice_Site	NM_000828.4	NP_000819.3	P42263	GRIA3_HUMAN	glutamate receptor, ionotropic, AMPA 3						glutamate signaling pathway|synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|endocytic vesicle membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity	p.?(3)		breast(2)|central_nervous_system(1)|endometrium(8)|kidney(3)|large_intestine(8)|lung(25)|ovary(3)|pancreas(2)|skin(2)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(1)	57					L-Glutamic Acid(DB00142)	CTCTCGAAAAGTAAGTAACCA	0.318000													85	136					1.10345e-40	1.19353e-40	1	1	0
ZNF845	91664	broad.mit.edu	37	19	53856007	53856007	+	Missense_Mutation	SNP	T	T	G			TCGA-DH-A7UR-01A-11D-A33T-08	TCGA-DH-A7UR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f04342d6-2f32-40ec-a731-3e7bd18ffffe	bfcd7244-5a98-40a6-9328-e7fe970754e9	g.chr19:53856007T>G	ENST00000458035.1	+	4	2196	c.2079T>G	c.(2077-2079)tgT>tgG	p.C693W	ZNF845_ENST00000595091.1_Missense_Mutation_p.C693W	NM_138374.1	NP_612383.1	Q96IR2	ZN845_HUMAN	zinc finger protein 845	693				Missing (in Ref. 1; BAG58121).	regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(2)|kidney(10)|lung(7)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|urinary_tract(2)	26						CTTACAAGTGTAATGAGTGTG	0.423000													54	75					0	0	1	0	0
SERGEF	26297	broad.mit.edu	37	11	17981080	17981080	+	Silent	SNP	G	G	A			TCGA-DH-A7UR-01A-11D-A33T-08	TCGA-DH-A7UR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f04342d6-2f32-40ec-a731-3e7bd18ffffe	bfcd7244-5a98-40a6-9328-e7fe970754e9	g.chr11:17981080G>A	ENST00000265965.5	-	9	1099	c.948C>T	c.(946-948)ctC>ctT	p.L316L	SERGEF_ENST00000528200.1_Intron|SERGEF_ENST00000532265.1_Intron	NM_012139.2	NP_036271.1	Q9UGK8	SRGEF_HUMAN	secretion regulating guanine nucleotide exchange factor	316					negative regulation of protein secretion|signal transduction	cytoplasm|nucleus	protein binding|Ran guanyl-nucleotide exchange factor activity			autonomic_ganglia(1)|central_nervous_system(1)|large_intestine(5)|lung(5)	12						TTGAACAGGGGAGAAATGAAT	0.488000													44	66					0	0	1	0	0
TRAF7	84231	broad.mit.edu	37	16	2225554	2225554	+	Silent	SNP	C	C	T			TCGA-DH-A7UR-01A-11D-A33T-08	TCGA-DH-A7UR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f04342d6-2f32-40ec-a731-3e7bd18ffffe	bfcd7244-5a98-40a6-9328-e7fe970754e9	g.chr16:2225554C>T	ENST00000326181.6	+	17	1689	c.1557C>T	c.(1555-1557)ctC>ctT	p.L519L		NM_032271.2	NP_115647.2	Q6Q0C0	TRAF7_HUMAN	TNF receptor-associated factor 7, E3 ubiquitin protein ligase	519					activation of MAPKKK activity|apoptosis|regulation of apoptosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic membrane-bounded vesicle|ubiquitin ligase complex	identical protein binding|ubiquitin-protein ligase activity|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(8)|ovary(1)|pancreas(1)|prostate(2)|skin(1)	23						TCACAGGCCTCAACCACTGGG	0.637000													8	131					0	0	1	0	0
PARK7	0	broad.mit.edu	37	1	8037767	8037767	+	Silent	SNP	C	C	T			TCGA-DH-A7UR-01A-11D-A33T-08	TCGA-DH-A7UR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f04342d6-2f32-40ec-a731-3e7bd18ffffe	bfcd7244-5a98-40a6-9328-e7fe970754e9	g.chr1:8037767C>T	ENST00000493678.1	+	6	445	c.378C>T	c.(376-378)caC>caT	p.H126H	PARK7_ENST00000338639.5_Silent_p.H126H|PARK7_ENST00000377491.1_Silent_p.H126H|PARK7_ENST00000377493.5_Silent_p.H106H|PARK7_ENST00000377488.1_Silent_p.H126H			Q99497	PARK7_HUMAN	parkinson protein 7	126					autophagy|cell death|cellular response to hydrogen peroxide|inflammatory response|mitochondrion organization|negative regulation of cell death|negative regulation of protein binding|neuroprotection|protein stabilization|regulation of androgen receptor signaling pathway|regulation of inflammatory response|single fertilization	mitochondrion|nucleus	mRNA binding|peptidase activity|peroxidase activity|protein homodimerization activity			large_intestine(1)	1	Ovarian(185;0.06)|all_lung(157;0.151)	all_epithelial(116;1.76e-16)|all_lung(118;3.66e-05)|Lung NSC(185;0.000163)|Renal(390;0.000469)|Colorectal(325;0.0033)|Breast(348;0.0044)|Hepatocellular(190;0.0228)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.11)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;1.28e-70)|GBM - Glioblastoma multiforme(8;3.05e-36)|Colorectal(212;6.83e-08)|COAD - Colon adenocarcinoma(227;7.51e-06)|Kidney(185;5.22e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000414)|KIRC - Kidney renal clear cell carcinoma(229;0.000967)|STAD - Stomach adenocarcinoma(132;0.00102)|READ - Rectum adenocarcinoma(331;0.0649)		TTACAACACACCCTCTTGCTA	0.373000													4	73					0	0	1	0	0
FCRL4	83417	broad.mit.edu	37	1	157545510	157545510	+	Silent	SNP	G	G	A			TCGA-DH-A7UR-01A-11D-A33T-08	TCGA-DH-A7UR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f04342d6-2f32-40ec-a731-3e7bd18ffffe	bfcd7244-5a98-40a6-9328-e7fe970754e9	g.chr1:157545510G>A	ENST00000271532.1	-	11	1575	c.1440C>T	c.(1438-1440)tcC>tcT	p.S480S	FCRL4_ENST00000448509.2_5'UTR	NM_031282.2	NP_112572.1	Q96PJ5	FCRL4_HUMAN	Fc receptor-like 4	480						integral to membrane|plasma membrane	receptor activity			breast(2)|central_nervous_system(2)|endometrium(1)|kidney(3)|large_intestine(5)|lung(20)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	40	all_hematologic(112;0.0378)|Hepatocellular(266;0.178)	Prostate(1639;0.245)				GAAGTGTCCTGGAGGTATTAG	0.463000													74	123					0	0	1	0	0
FMNL3	91010	broad.mit.edu	37	12	50045824	50045824	+	Missense_Mutation	SNP	G	G	A			TCGA-DH-A7UR-01A-11D-A33T-08	TCGA-DH-A7UR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f04342d6-2f32-40ec-a731-3e7bd18ffffe	bfcd7244-5a98-40a6-9328-e7fe970754e9	g.chr12:50045824G>A	ENST00000335154.5	-	14	1728	c.1495C>T	c.(1495-1497)Cca>Tca	p.P499S	FMNL3_ENST00000352151.5_Missense_Mutation_p.P448S|FMNL3_ENST00000550488.1_Missense_Mutation_p.P499S|FMNL3_ENST00000293590.5_Missense_Mutation_p.P499S	NM_175736.4	NP_783863.4	Q8IVF7	FMNL3_HUMAN	formin-like 3	499	Pro-rich.				actin cytoskeleton organization		actin binding|Rho GTPase binding			breast(4)|endometrium(7)|kidney(2)|large_intestine(6)|lung(11)|ovary(2)|pancreas(2)|prostate(2)|skin(2)|stomach(1)	39						TCGGAGGGTGGCATGCCCTCA	0.662000													3	32					0	0	1	0	0
LATS2	26524	broad.mit.edu	37	13	21549235	21549235	+	Missense_Mutation	SNP	G	G	A	rs45523141	byFrequency	TCGA-DH-A7UR-01A-11D-A33T-08	TCGA-DH-A7UR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f04342d6-2f32-40ec-a731-3e7bd18ffffe	bfcd7244-5a98-40a6-9328-e7fe970754e9	g.chr13:21549235G>A	ENST00000382592.4	-	8	3446	c.3041C>T	c.(3040-3042)gCc>gTc	p.A1014V	LATS2_ENST00000542899.1_Missense_Mutation_p.A1014V	NM_014572.2	NP_055387.2	Q9NRM7	LATS2_HUMAN	large tumor suppressor kinase 2	1014	AGC-kinase C-terminal.		A -> G (in dbSNP:rs45523141).		cell division|G1/S transition of mitotic cell cycle|hippo signaling cascade|hormone-mediated signaling pathway|intracellular protein kinase cascade|mitosis|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cyclin-dependent protein kinase activity	microtubule organizing center|nucleus|spindle pole	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			breast(4)|central_nervous_system(3)|endometrium(2)|kidney(2)|large_intestine(7)|lung(19)|ovary(3)|pancreas(1)|prostate(2)|urinary_tract(2)	45		all_cancers(29;4.74e-22)|all_epithelial(30;1.45e-18)|all_lung(29;4.69e-16)|Lung SC(185;0.0262)|Hepatocellular(188;0.244)		all cancers(112;0.000781)|Epithelial(112;0.00144)|OV - Ovarian serous cystadenocarcinoma(117;0.0183)|Lung(94;0.0375)|LUSC - Lung squamous cell carcinoma(192;0.104)		ACCTTCGCTGGCATCGTTCCA	0.547000													5	235					0	0	1	0	0
C10orf76	79591	broad.mit.edu	37	10	103783291	103783291	+	Missense_Mutation	SNP	C	C	G			TCGA-DH-A7UR-01A-11D-A33T-08	TCGA-DH-A7UR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f04342d6-2f32-40ec-a731-3e7bd18ffffe	bfcd7244-5a98-40a6-9328-e7fe970754e9	g.chr10:103783291C>G	ENST00000370033.4	-	8	731	c.612G>C	c.(610-612)gaG>gaC	p.E204D		NM_024541.2	NP_078817.2	Q5T2E6	CJ076_HUMAN	chromosome 10 open reading frame 76	204						integral to membrane				autonomic_ganglia(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(7)|prostate(2)|upper_aerodigestive_tract(2)	24		Colorectal(252;0.123)		Epithelial(162;2.41e-08)|all cancers(201;6.41e-07)		CATACCCATGCTCCCTACGAC	0.438000													46	82					0	0	1	0	0
AREL1	9870	broad.mit.edu	37	14	75134270	75134270	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DH-A7UR-01A-11D-A33T-08	TCGA-DH-A7UR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f04342d6-2f32-40ec-a731-3e7bd18ffffe	bfcd7244-5a98-40a6-9328-e7fe970754e9	g.chr14:75134270G>A	ENST00000356357.4	-	16	2457	c.1942C>T	c.(1942-1944)Caa>Taa	p.Q648*	AREL1_ENST00000557401.1_5'UTR	NM_001039479.1	NP_001034568.1			apoptosis resistant E3 ubiquitin protein ligase 1																		ACTGGAGTTTGAGCTCCACCT	0.443000													46	72					0	0	1	0	0
RPTN	126638	broad.mit.edu	37	1	152129200	152129200	+	Silent	SNP	G	G	A			TCGA-DH-A7UR-01A-11D-A33T-08	TCGA-DH-A7UR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f04342d6-2f32-40ec-a731-3e7bd18ffffe	bfcd7244-5a98-40a6-9328-e7fe970754e9	g.chr1:152129200G>A	ENST00000316073.3	-	3	439	c.375C>T	c.(373-375)caC>caT	p.H125H		NM_001122965.1	NP_001116437.1	Q6XPR3	RPTN_HUMAN	repetin	125	Gln-rich.					proteinaceous extracellular matrix	calcium ion binding			breast(2)|central_nervous_system(1)|endometrium(14)|kidney(2)|large_intestine(1)|lung(32)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	59						TTTCTTCCTCGTGCCTCTGTC	0.542000													41	407					0	0	1	0	0
PITPNM2	57605	broad.mit.edu	37	12	123481449	123481449	+	Missense_Mutation	SNP	G	G	T			TCGA-DH-A7UR-01A-11D-A33T-08	TCGA-DH-A7UR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f04342d6-2f32-40ec-a731-3e7bd18ffffe	bfcd7244-5a98-40a6-9328-e7fe970754e9	g.chr12:123481449G>T	ENST00000280562.5	-	11	1686	c.1481C>A	c.(1480-1482)cCc>cAc	p.P494H	PITPNM2_ENST00000392428.1_Missense_Mutation_p.P215H|PITPNM2_ENST00000320201.4_Missense_Mutation_p.P494H|PITPNM2_ENST00000542749.1_Missense_Mutation_p.P494H			Q9BZ72	PITM2_HUMAN	phosphatidylinositol transfer protein, membrane-associated 2	494					metabolic process|transport	endomembrane system|integral to membrane|intracellular membrane-bounded organelle	calcium ion binding|lipid binding			NS(2)|central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(10)|ovary(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	39	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;2.55e-05)|Epithelial(86;8.43e-05)|BRCA - Breast invasive adenocarcinoma(302;0.123)		ATGGCTGTAGGGGCTGAGGCT	0.662000													24	33					7.92952e-12	8.24048e-12	1	1	0
ZAN	7455	broad.mit.edu	37	7	100350298	100350298	+	RNA	SNP	C	C	T			TCGA-DH-A7UR-01A-11D-A33T-08	TCGA-DH-A7UR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f04342d6-2f32-40ec-a731-3e7bd18ffffe	bfcd7244-5a98-40a6-9328-e7fe970754e9	g.chr7:100350298C>T	ENST00000542585.1	+	0	2718				ZAN_ENST00000538115.1_RNA|ZAN_ENST00000348028.3_RNA|ZAN_ENST00000449052.1_RNA|ZAN_ENST00000421100.1_RNA|ZAN_ENST00000349350.6_RNA|ZAN_ENST00000546292.1_RNA|ZAN_ENST00000546213.1_RNA|ZAN_ENST00000443370.1_RNA|ZAN_ENST00000427578.1_RNA	NM_003386.1	NP_003377.1	Q9Y493	ZAN_HUMAN	zonadhesin (gene/pseudogene)						binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				NS(2)|breast(3)|central_nervous_system(3)|endometrium(21)|kidney(6)|large_intestine(18)|lung(60)|ovary(4)|pancreas(3)|prostate(5)|skin(8)|stomach(3)|upper_aerodigestive_tract(3)	139	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			ACAGAAAAACCCACCATCCCC	0.498000													5	244					0	0	1	0	0
TNR	7143	broad.mit.edu	37	1	175355252	175355252	+	Missense_Mutation	SNP	G	G	A			TCGA-DH-A7UR-01A-11D-A33T-08	TCGA-DH-A7UR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f04342d6-2f32-40ec-a731-3e7bd18ffffe	bfcd7244-5a98-40a6-9328-e7fe970754e9	g.chr1:175355252G>A	ENST00000367674.1	-	8	2401	c.1693C>T	c.(1693-1695)Cgg>Tgg	p.R565W	TNR_ENST00000263525.2_Missense_Mutation_p.R565W	NM_003285.2	NP_003276.3	Q92752	TENR_HUMAN	tenascin R	565	Fibronectin type-III 3.				axon guidance|cell adhesion|signal transduction	proteinaceous extracellular matrix				NS(3)|breast(7)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(29)|lung(98)|ovary(4)|pancreas(5)|prostate(4)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	177	Renal(580;0.146)					GAGCCAGGCCGCAGGGCCTGC	0.607000													4	139					0	0	1	0	0
AJ271736.10	0	broad.mit.edu	37	X	155255043	155255043	+	RNA	SNP	G	G	A			TCGA-DH-A7UR-01A-11D-A33T-08	TCGA-DH-A7UR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f04342d6-2f32-40ec-a731-3e7bd18ffffe	bfcd7244-5a98-40a6-9328-e7fe970754e9	g.chrX:155255043G>A	ENST00000285718.7	+	0	1348				WASH6P_ENST00000461007.1_RNA																							ATCCTAGGGGGCTCCATGACA	0.642000													4	47					0	0	1	0	0
FUBP1	8880	broad.mit.edu	37	1	78430644	78430644	+	Nonsense_Mutation	SNP	C	C	A			TCGA-DH-A7UR-01A-11D-A33T-08	TCGA-DH-A7UR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f04342d6-2f32-40ec-a731-3e7bd18ffffe	bfcd7244-5a98-40a6-9328-e7fe970754e9	g.chr1:78430644C>A	ENST00000370767.1	-	9	733	c.646G>T	c.(646-648)Gga>Tga	p.G216*	FUBP1_ENST00000436586.2_Nonsense_Mutation_p.G237*|FUBP1_ENST00000370768.2_Nonsense_Mutation_p.G216*			Q96AE4	FUBP1_HUMAN	far upstream element (FUSE) binding protein 1	216	KH 2.				transcription from RNA polymerase II promoter	nucleus	protein binding|RNA binding|sequence-specific DNA binding transcription factor activity|single-stranded DNA binding			central_nervous_system(7)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(4)|lung(1)|upper_aerodigestive_tract(3)	17						ATTTTAACTCCAGCCCGTTCC	0.363000			"""F, N"""		oligodendroglioma								71	45					2.40655e-23	2.57671e-23	1	1	0
NCKAP1L	3071	broad.mit.edu	37	12	54917307	54917307	+	Missense_Mutation	SNP	C	C	T			TCGA-DH-A7UR-01A-11D-A33T-08	TCGA-DH-A7UR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f04342d6-2f32-40ec-a731-3e7bd18ffffe	bfcd7244-5a98-40a6-9328-e7fe970754e9	g.chr12:54917307C>T	ENST00000293373.6	+	19	2087	c.2008C>T	c.(2008-2010)Cgc>Tgc	p.R670C	NCKAP1L_ENST00000545638.2_Missense_Mutation_p.R620C	NM_005337.4	NP_005328.2	P55160	NCKPL_HUMAN	NCK-associated protein 1-like	670					actin polymerization-dependent cell motility|B cell homeostasis|B cell receptor signaling pathway|cortical actin cytoskeleton organization|erythrocyte development|maintenance of cell polarity|myeloid cell homeostasis|negative regulation of apoptosis|negative regulation of interleukin-17 production|negative regulation of interleukin-6 production|negative regulation of myosin-light-chain-phosphatase activity|neutrophil chemotaxis|positive regulation of actin filament polymerization|positive regulation of B cell differentiation|positive regulation of B cell proliferation|positive regulation of CD4-positive, alpha-beta T cell differentiation|positive regulation of CD8-positive, alpha-beta T cell differentiation|positive regulation of cell adhesion mediated by integrin|positive regulation of erythrocyte differentiation|positive regulation of gamma-delta T cell differentiation|positive regulation of neutrophil chemotaxis|positive regulation of phagocytosis, engulfment|positive regulation of T cell proliferation|protein complex assembly|response to drug|T cell homeostasis	cytosol|integral to plasma membrane|membrane fraction|SCAR complex	protein complex binding|protein kinase activator activity|Rac GTPase activator activity			NS(3)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(37)|ovary(3)|prostate(3)|skin(3)|stomach(2)	80						CCGGAAGAACCGCAGCATTGT	0.542000													9	121					0	0	1	0	0
OR4S2	219431	broad.mit.edu	37	11	55418641	55418641	+	Missense_Mutation	SNP	A	A	C			TCGA-DH-A7UR-01A-11D-A33T-08	TCGA-DH-A7UR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f04342d6-2f32-40ec-a731-3e7bd18ffffe	bfcd7244-5a98-40a6-9328-e7fe970754e9	g.chr11:55418641A>C	ENST00000312422.2	+	1	262	c.262A>C	c.(262-264)Aaa>Caa	p.K88Q		NM_001004059.2	NP_001004059.2	Q8NH73	OR4S2_HUMAN	olfactory receptor, family 4, subfamily S, member 2	88					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(2)|large_intestine(4)|lung(28)|ovary(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	45		all_epithelial(135;0.0748)				AGCAAAGGACAAAACCATCTC	0.418000													142	262					0	0	1	0	0
ZEB1	6935	broad.mit.edu	37	10	31784731	31784731	+	Missense_Mutation	SNP	G	G	C			TCGA-DH-A7UR-01A-11D-A33T-08	TCGA-DH-A7UR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f04342d6-2f32-40ec-a731-3e7bd18ffffe	bfcd7244-5a98-40a6-9328-e7fe970754e9	g.chr10:31784731G>C	ENST00000446923.2	+	3	626	c.235G>C	c.(235-237)Ggg>Cgg	p.G79R	ZEB1_ENST00000560721.2_Intron|ZEB1_ENST00000320985.10_Missense_Mutation_p.G95R|ZEB1_ENST00000559858.1_3'UTR|ZEB1_ENST00000542815.3_Missense_Mutation_p.G28R|ZEB1_ENST00000361642.5_Missense_Mutation_p.G96R	NM_001128128.2|NM_001174094.1	NP_001121600.1|NP_001167565.1	P37275	ZEB1_HUMAN	zinc finger E-box binding homeobox 1	95					cell proliferation|immune response|negative regulation of transcription from RNA polymerase II promoter|positive regulation of neuron differentiation	cytoplasm	E-box binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity|zinc ion binding			NS(2)|breast(4)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(14)|lung(38)|ovary(3)|skin(6)|upper_aerodigestive_tract(4)	77		Prostate(175;0.0156)				AGAAATCCTGGGGCCTGAAGC	0.383000													5	180					0	0	1	0	0
FAT4	79633	broad.mit.edu	37	4	126373108	126373108	+	Missense_Mutation	SNP	G	G	A			TCGA-DH-A7UR-01A-11D-A33T-08	TCGA-DH-A7UR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f04342d6-2f32-40ec-a731-3e7bd18ffffe	bfcd7244-5a98-40a6-9328-e7fe970754e9	g.chr4:126373108G>A	ENST00000394329.3	+	9	10950	c.10937G>A	c.(10936-10938)aGc>aAc	p.S3646N	FAT4_ENST00000335110.5_Missense_Mutation_p.S1944N	NM_024582.4	NP_078858.4	Q6V0I7	FAT4_HUMAN	FAT atypical cadherin 4	3646					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						GTGTTAGACAGCTTCCACTGC	0.478000													70	137					0	0	1	0	0
PSD4	23550	broad.mit.edu	37	2	113958749	113958749	+	Silent	SNP	G	G	A			TCGA-DH-A7UR-01A-11D-A33T-08	TCGA-DH-A7UR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f04342d6-2f32-40ec-a731-3e7bd18ffffe	bfcd7244-5a98-40a6-9328-e7fe970754e9	g.chr2:113958749G>A	ENST00000245796.6	+	17	3123	c.2928G>A	c.(2926-2928)gaG>gaA	p.E976E	PSD4_ENST00000441564.2_Silent_p.E947E	NM_012455.2	NP_036587.2	Q8NDX1	PSD4_HUMAN	pleckstrin and Sec7 domain containing 4	976					regulation of ARF protein signal transduction	cytoplasm|plasma membrane	ARF guanyl-nucleotide exchange factor activity			cervix(1)|endometrium(2)|large_intestine(4)|lung(13)|ovary(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29						CCCGCTACGAGACCTACGTGC	0.632000													8	279					0	0	1	0	0
TNFRSF8	0	broad.mit.edu	37	1	12144582	12144582	+	Missense_Mutation	SNP	G	G	A			TCGA-DH-A7UR-01A-11D-A33T-08	TCGA-DH-A7UR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f04342d6-2f32-40ec-a731-3e7bd18ffffe	bfcd7244-5a98-40a6-9328-e7fe970754e9	g.chr1:12144582G>A	ENST00000263932.2	+	2	347	c.125G>A	c.(124-126)aGg>aAg	p.R42K	TNFRSF8_ENST00000417814.2_Intron	NM_001243.3	NP_001234.2	P28908	TNR8_HUMAN	tumor necrosis factor receptor superfamily, member 8	42					cellular response to mechanical stimulus|negative regulation of cell proliferation|positive regulation of apoptosis|positive regulation of TRAIL biosynthetic process|positive regulation of tumor necrosis factor biosynthetic process	cytoplasm|integral to membrane|plasma membrane				NS(1)|breast(2)|central_nervous_system(1)|endometrium(2)|large_intestine(4)|lung(12)|ovary(1)|pancreas(1)|skin(2)|urinary_tract(1)	27	Ovarian(185;0.249)	Lung NSC(185;8.71e-05)|all_lung(284;9.89e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;5.66e-06)|COAD - Colon adenocarcinoma(227;0.000261)|BRCA - Breast invasive adenocarcinoma(304;0.000304)|Kidney(185;0.000777)|KIRC - Kidney renal clear cell carcinoma(229;0.00261)|STAD - Stomach adenocarcinoma(313;0.0073)|READ - Rectum adenocarcinoma(331;0.0649)		AAGGCTGTCAGGAGGTGCTGT	0.582000													45	41					0	0	1	0	0
TUBB8	347688	broad.mit.edu	37	10	93373	93373	+	Missense_Mutation	SNP	C	C	T			TCGA-DH-A7UR-01A-11D-A33T-08	TCGA-DH-A7UR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f04342d6-2f32-40ec-a731-3e7bd18ffffe	bfcd7244-5a98-40a6-9328-e7fe970754e9	g.chr10:93373C>T	ENST00000447903.2	-	4	1058	c.743G>A	c.(742-744)cGc>cAc	p.R248H	TUBB8_ENST00000309812.4_Missense_Mutation_p.R320H			Q3ZCM7	TBB8_HUMAN	tubulin, beta 8 class VIII	320					microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|structural molecule activity			NS(1)|cervix(1)|endometrium(4)|large_intestine(5)|lung(12)|ovary(2)|prostate(3)|skin(3)|stomach(1)	32		all_cancers(4;0.00131)|all_lung(4;0.000777)|Lung NSC(4;0.0043)|all_epithelial(10;0.0154)|Colorectal(49;0.235)		Epithelial(11;0.00341)|all cancers(11;0.00922)|OV - Ovarian serous cystadenocarcinoma(14;0.0508)|Lung(33;0.132)		CATGGGCATGCGACCCCTGAA	0.522000													5	278					0	0	1	0	0
ABCA2	20	broad.mit.edu	37	9	139905168	139905168	+	Silent	SNP	C	C	T			TCGA-DH-A7UR-01A-11D-A33T-08	TCGA-DH-A7UR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f04342d6-2f32-40ec-a731-3e7bd18ffffe	bfcd7244-5a98-40a6-9328-e7fe970754e9	g.chr9:139905168C>T	ENST00000265662.5	-	40	6225	c.6078G>A	c.(6076-6078)aaG>aaA	p.K2026K	ABCA2_ENST00000371605.3_Silent_p.K2025K|ABCA2_ENST00000341511.6_Silent_p.K2026K			Q9BZC7	ABCA2_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 2	2025					cholesterol homeostasis|lipid metabolic process|regulation of intracellular cholesterol transport|regulation of transcription from RNA polymerase II promoter|response to drug|response to steroid hormone stimulus	ATP-binding cassette (ABC) transporter complex|cytoplasmic membrane-bounded vesicle|endosome|integral to membrane|microtubule organizing center	ATP binding|ATPase activity, coupled to transmembrane movement of substances			central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|liver(1)|lung(25)|prostate(2)|skin(1)|stomach(1)|urinary_tract(1)	41	all_cancers(76;0.16)	Myeloproliferative disorder(178;0.0511)	STAD - Stomach adenocarcinoma(284;0.123)	OV - Ovarian serous cystadenocarcinoma(145;2.94e-05)|Epithelial(140;0.00048)		CCTCCACAGGCTTGGTAGACA	0.637000													60	94					0	0	1	0	0
KIF5B	3799	broad.mit.edu	37	10	32320036	32320036	+	Missense_Mutation	SNP	A	A	T			TCGA-DH-A7UR-01A-11D-A33T-08	TCGA-DH-A7UR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f04342d6-2f32-40ec-a731-3e7bd18ffffe	bfcd7244-5a98-40a6-9328-e7fe970754e9	g.chr10:32320036A>T	ENST00000302418.4	-	14	2003	c.1546T>A	c.(1546-1548)Tat>Aat	p.Y516N		NM_004521.2	NP_004512.1	P33176	KINH_HUMAN	kinesin family member 5B	516					stress granule disassembly|vesicle transport along microtubule	kinesin complex|microtubule|perinuclear region of cytoplasm|vesicle	ATP binding|microtubule binding|microtubule motor activity		KIF5B/ALK(8)|KIF5B/RET(79)	NS(2)|breast(1)|endometrium(5)|kidney(2)|large_intestine(12)|lung(11)|ovary(1)|prostate(1)	35		Prostate(175;0.0137)				AGCAATTCATATTCCTTAGTT	0.318000			T	"""RET, ALK"""	NSCLC								18	107					0	0	1	0	0
PRKCI	5584	broad.mit.edu	37	3	169998192	169998192	+	Splice_Site	SNP	G	G	A			TCGA-DH-A7UR-01A-11D-A33T-08	TCGA-DH-A7UR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f04342d6-2f32-40ec-a731-3e7bd18ffffe	bfcd7244-5a98-40a6-9328-e7fe970754e9	g.chr3:169998192G>A	ENST00000295797.4	+	9	1187		c.e9+1			NM_002740.5	NP_002731.4	P41743	KPCI_HUMAN	protein kinase C, iota						anti-apoptosis|cellular membrane organization|cellular response to insulin stimulus|establishment or maintenance of epithelial cell apical/basal polarity|intracellular signal transduction|nerve growth factor receptor signaling pathway|positive regulation of establishment of protein localization in plasma membrane|positive regulation of glucose import|protein targeting to membrane|secretion|tight junction assembly|vesicle-mediated transport	cytosol|endosome|nucleus|polarisome	ATP binding|phospholipid binding|protein binding|protein kinase C activity|zinc ion binding			breast(2)|endometrium(5)|kidney(1)|large_intestine(4)|lung(16)|ovary(2)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	36	all_cancers(22;6.45e-23)|all_epithelial(15;8.52e-28)|all_lung(20;6.31e-17)|Lung NSC(18;2.61e-16)|Ovarian(172;0.000337)|Breast(254;0.169)		Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.197)			TGATGATGAGGTAAGCACTGC	0.348000													19	55					0	0	1	0	0
MFSD5	84975	broad.mit.edu	37	12	53647528	53647528	+	Silent	SNP	C	C	T			TCGA-DH-A7UR-01A-11D-A33T-08	TCGA-DH-A7UR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f04342d6-2f32-40ec-a731-3e7bd18ffffe	bfcd7244-5a98-40a6-9328-e7fe970754e9	g.chr12:53647528C>T	ENST00000534842.1	+	2	1377	c.1230C>T	c.(1228-1230)acC>acT	p.T410T	MFSD5_ENST00000329548.4_Silent_p.T303T	NM_001170790.1	NP_001164261.1	Q6N075	MFSD5_HUMAN	major facilitator superfamily domain containing 5	303					transport	integral to membrane				breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(3)|ovary(1)|skin(3)|urinary_tract(1)	16						GTATCGCCACCTCCAAGAGGT	0.587000													38	81					0	0	1	0	0
NBPF1	55672	broad.mit.edu	37	1	16891370	16891372	+	In_Frame_Del	DEL	TCT	TCT	-			TCGA-DH-A7UR-01A-11D-A33T-08	TCGA-DH-A7UR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f04342d6-2f32-40ec-a731-3e7bd18ffffe	bfcd7244-5a98-40a6-9328-e7fe970754e9	g.chr1:16891370_16891372delTCT	ENST00000430580.2	-	28	3993_3995	c.3106_3108delAGA	c.(3106-3108)del	p.R1036del		NM_017940.3	NP_060410.2	Q3BBV0	NBPF1_HUMAN	neuroblastoma breakpoint family, member 1	1026	NBPF 6.					cytoplasm									UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.52e-06)|COAD - Colon adenocarcinoma(227;1.05e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.179)		tcttcgttgatcttcttcccctt	0.414													31	1771	---	---	---	---					
KIFAP3	22920	broad.mit.edu	37	1	170003518	170003520	+	In_Frame_Del	DEL	TTC	TTC	-			TCGA-DH-A7UR-01A-11D-A33T-08	TCGA-DH-A7UR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f04342d6-2f32-40ec-a731-3e7bd18ffffe	bfcd7244-5a98-40a6-9328-e7fe970754e9	g.chr1:170003518_170003520delTTC	ENST00000367765.1	-	7	2116_2118	c.615_617delGAA	c.(613-618)aaa>aa	p.KK205del	KIFAP3_ENST00000538366.1_In_Frame_Del_p.KK167del|KIFAP3_ENST00000361580.2_In_Frame_Del_p.KK245del|KIFAP3_ENST00000367767.1_In_Frame_Del_p.KK201del	NM_001204517.1	NP_001191446.1	Q92845	KIFA3_HUMAN	kinesin-associated protein 3	245					blood coagulation|plus-end-directed vesicle transport along microtubule|protein complex assembly|signal transduction	centrosome|condensed nuclear chromosome|cytosol|endoplasmic reticulum|kinesin II complex|spindle microtubule	kinesin binding			endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(18)|prostate(2)|skin(3)|urinary_tract(2)	35	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					GATATCAGCTTTCTTCTTCTTTG	0.330													16	124	---	---	---	---					
USP40	55230	broad.mit.edu	37	2	234465531	234465534	+	Frame_Shift_Del	DEL	ACAA	ACAA	-			TCGA-DH-A7UR-01A-11D-A33T-08	TCGA-DH-A7UR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f04342d6-2f32-40ec-a731-3e7bd18ffffe	bfcd7244-5a98-40a6-9328-e7fe970754e9	g.chr2:234465531_234465534delACAA	ENST00000251722.6	-	5	630_633	c.513_516delTTGT	c.(511-516)gtfs	p.VC171fs	USP40_ENST00000450966.1_Frame_Shift_Del_p.VC183fs|USP40_ENST00000427112.2_Frame_Shift_Del_p.VC171fs			Q9NVE5	UBP40_HUMAN	ubiquitin specific peptidase 40	171					ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity			breast(1)|endometrium(6)|kidney(5)|large_intestine(5)|lung(10)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	30		Breast(86;0.0013)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0179)|Acute lymphoblastic leukemia(138;0.0326)|Lung NSC(271;0.0539)		Epithelial(121;1.71e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000407)|Lung(119;0.00277)|LUSC - Lung squamous cell carcinoma(224;0.00646)		TACATTCTTTACAAACAATCTGGT	0.363													27	55	---	---	---	---					
RFC4	5984	broad.mit.edu	37	3	186509619	186509620	+	Frame_Shift_Del	DEL	TT	TT	-			TCGA-DH-A7UR-01A-11D-A33T-08	TCGA-DH-A7UR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f04342d6-2f32-40ec-a731-3e7bd18ffffe	bfcd7244-5a98-40a6-9328-e7fe970754e9	g.chr3:186509619_186509620delTT	ENST00000392481.2	-	8	976_977	c.695_696delAA	c.(694-696)afs	p.K232fs	RFC4_ENST00000433496.1_Frame_Shift_Del_p.K232fs|RFC4_ENST00000296273.2_Frame_Shift_Del_p.K232fs	NM_181573.2	NP_853551.1	P35249	RFC4_HUMAN	replication factor C (activator 1) 4, 37kDa	232					cell cycle checkpoint|DNA strand elongation involved in DNA replication|nucleotide-excision repair, DNA gap filling|phosphatidylinositol-mediated signaling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	DNA replication factor C complex|nucleoplasm	ATP binding|DNA clamp loader activity|protein binding			breast(3)|kidney(3)|large_intestine(5)|lung(9)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	26	all_cancers(143;2.92e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;7.41e-21)	GBM - Glioblastoma multiforme(93;0.0739)		CTTCTGACACTTTAACAAGATA	0.322													20	146	---	---	---	---					
EVC2	132884	broad.mit.edu	37	4	5642373	5642375	+	In_Frame_Del	DEL	CTC	CTC	-			TCGA-DH-A7UR-01A-11D-A33T-08	TCGA-DH-A7UR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f04342d6-2f32-40ec-a731-3e7bd18ffffe	bfcd7244-5a98-40a6-9328-e7fe970754e9	g.chr4:5642373_5642375delCTC	ENST00000310917.2	-	10	1827_1829	c.1096_1098delGAG	c.(1096-1098)del	p.E366del	EVC2_ENST00000344408.5_In_Frame_Del_p.E446del|EVC2_ENST00000344938.1_In_Frame_Del_p.E446del	NM_001166136.1	NP_001159608.1	Q86UK5	LBN_HUMAN	Ellis van Creveld syndrome 2	446						integral to membrane		p.E446G(1)		NS(2)|breast(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(32)|lung(28)|ovary(4)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|urinary_tract(2)	81						TCCGATCGTACTCCTCTTGTATT	0.438													116	298	---	---	---	---					
RBPJ	3516	broad.mit.edu	37	4	26426292	26426293	+	Frame_Shift_Del	DEL	GA	GA	-			TCGA-DH-A7UR-01A-11D-A33T-08	TCGA-DH-A7UR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f04342d6-2f32-40ec-a731-3e7bd18ffffe	bfcd7244-5a98-40a6-9328-e7fe970754e9	g.chr4:26426292_26426293delGA	ENST00000342320.4	+	7	847_848	c.671_672delGA	c.(670-672)cfs	p.R224fs	RBPJ_ENST00000345843.3_Frame_Shift_Del_p.R223fs|RBPJ_ENST00000504907.1_Frame_Shift_Del_p.R224fs|RBPJ_ENST00000361572.6_Frame_Shift_Del_p.R238fs|RBPJ_ENST00000342295.1_Frame_Shift_Del_p.R238fs|RBPJ_ENST00000507561.1_Frame_Shift_Del_p.R203fs|RBPJ_ENST00000355476.3_Frame_Shift_Del_p.R224fs|RBPJ_ENST00000348160.4_Frame_Shift_Del_p.R225fs			Q06330	SUH_HUMAN	recombination signal binding protein for immunoglobulin kappa J region	238					DNA recombination|negative regulation of transcription, DNA-dependent|positive regulation of transcription of Notch receptor target	cytoplasm|nucleolus|nucleoplasm	DNA binding|protein binding|recombinase activity|sequence-specific DNA binding transcription factor activity			central_nervous_system(2)|kidney(3)|large_intestine(5)|lung(4)|ovary(1)	15		Breast(46;0.0503)				TTCACAGTCCGAGATGGCTACA	0.376													7	107	---	---	---	---					
WDR19	57728	broad.mit.edu	37	4	39276459	39276462	+	Frame_Shift_Del	DEL	TGAG	TGAG	-			TCGA-DH-A7UR-01A-11D-A33T-08	TCGA-DH-A7UR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f04342d6-2f32-40ec-a731-3e7bd18ffffe	bfcd7244-5a98-40a6-9328-e7fe970754e9	g.chr4:39276459_39276462delTGAG	ENST00000399820.3	+	33	3751_3754	c.3597_3600delTGAG	c.(3595-3600)atfs	p.IE1199fs	WDR19_ENST00000288634.7_Frame_Shift_Del_p.IE1039fs	NM_025132.3	NP_079408.3	Q8NEZ3	WDR19_HUMAN	WD repeat domain 19	1199					cell projection organization	microtubule basal body|motile cilium|photoreceptor connecting cilium	binding			large_intestine(1)	1						CAACTGTGATTGAGTGTCACAGGG	0.490													16	240	---	---	---	---					
AASDH	132949	broad.mit.edu	37	4	57204654	57204658	+	Frame_Shift_Del	DEL	GAGAA	GAGAA	-	rs112962387		TCGA-DH-A7UR-01A-11D-A33T-08	TCGA-DH-A7UR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f04342d6-2f32-40ec-a731-3e7bd18ffffe	bfcd7244-5a98-40a6-9328-e7fe970754e9	g.chr4:57204654_57204658delGAGAA	ENST00000205214.6	-	15	3387_3391	c.3207_3211delTTCTC	c.(3205-3213)tcctfs	p.SSP1069fs	AASDH_ENST00000434343.2_Frame_Shift_Del_p.SSP584fs|AASDH_ENST00000513376.1_Frame_Shift_Del_p.SSP969fs|AASDH_ENST00000451613.1_3'UTR	NM_181806.2	NP_861522.2	Q4L235	ACSF4_HUMAN	aminoadipate-semialdehyde dehydrogenase	1069					fatty acid metabolic process		acid-thiol ligase activity|acyl carrier activity|ATP binding|cofactor binding			endometrium(2)|kidney(2)|large_intestine(8)|lung(17)|ovary(4)|prostate(3)|skin(2)|stomach(1)|urinary_tract(1)	40	Glioma(25;0.08)|all_neural(26;0.101)	all_hematologic(202;0.0017)				AGGACCACAGGAGAAGAGAAGACTT	0.400													25	104	---	---	---	---					
SMARCA5	8467	broad.mit.edu	37	4	144468620	144468622	+	In_Frame_Del	DEL	AAG	AAG	-			TCGA-DH-A7UR-01A-11D-A33T-08	TCGA-DH-A7UR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f04342d6-2f32-40ec-a731-3e7bd18ffffe	bfcd7244-5a98-40a6-9328-e7fe970754e9	g.chr4:144468620_144468622delAAG	ENST00000283131.3	+	21	3198_3200	c.2736_2738delAAG	c.(2734-2739)caa>ca	p.QR912del		NM_003601.3	NP_003592.3	O60264	SMCA5_HUMAN	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5	912					CenH3-containing nucleosome assembly at centromere|nucleosome positioning|regulation of transcription from RNA polymerase II promoter|transcription initiation, DNA-dependent	condensed chromosome|nucleolus|nucleoplasm|NURF complex|RSF complex	ATP binding|ATPase activity|DNA binding|helicase activity|nucleosome binding|protein binding	p.Q912Q(1)	EWSR1/SMARCA5(2)	endometrium(2)|kidney(2)|large_intestine(9)|lung(4)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	21	all_hematologic(180;0.158)					CGAGAATTCAAAGAAGAATAAGC	0.389													10	153	---	---	---	---					
STAG3L4	0	broad.mit.edu	37	7	66772494	66772495	+	RNA	INS	-	-	T	rs113583073		TCGA-DH-A7UR-01A-11D-A33T-08	TCGA-DH-A7UR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f04342d6-2f32-40ec-a731-3e7bd18ffffe	bfcd7244-5a98-40a6-9328-e7fe970754e9	g.chr7:66772494_66772495insT	ENST00000416602.2	+	0	362					NR_040586.1		Q8TBR4	STG34_HUMAN												endometrium(2)|lung(5)	7		Lung NSC(55;0.0839)|all_lung(88;0.181)				TGCTTGATTCCTTTTTTTTTTT	0.426													2	4	---	---	---	---					
ZNF212	7988	broad.mit.edu	37	7	148947380	148947382	+	In_Frame_Del	DEL	AGA	AGA	-			TCGA-DH-A7UR-01A-11D-A33T-08	TCGA-DH-A7UR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f04342d6-2f32-40ec-a731-3e7bd18ffffe	bfcd7244-5a98-40a6-9328-e7fe970754e9	g.chr7:148947380_148947382delAGA	ENST00000335870.2	+	2	283_285	c.155_157delAGA	c.(154-159)gag>g	p.EK52del		NM_012256.3	NP_036388.2	Q9UDV6	ZN212_HUMAN	zinc finger protein 212	52					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|identical protein binding|zinc ion binding			endometrium(2)|kidney(1)|large_intestine(4)|ovary(1)|prostate(1)	9	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00171)			CAGGCTGTGGAGAAGAAGATGGA	0.567													7	136	---	---	---	---					
MAP3K8	1326	broad.mit.edu	37	10	30739449	30739452	+	Splice_Site	DEL	GTAA	GTAA	-			TCGA-DH-A7UR-01A-11D-A33T-08	TCGA-DH-A7UR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f04342d6-2f32-40ec-a731-3e7bd18ffffe	bfcd7244-5a98-40a6-9328-e7fe970754e9	g.chr10:30739449_30739452delGTAA	ENST00000263056.1	+	5	1462		c.e5+1		MAP3K8_ENST00000542547.1_Splice_Site|MAP3K8_ENST00000375321.1_Splice_Site	NM_001244134.1|NM_005204.3	NP_001231063.1|NP_005195.2	P41279	M3K8_HUMAN	mitogen-activated protein kinase kinase kinase 8						cell cycle|T cell costimulation	cytosol	ATP binding|magnesium ion binding|MAP kinase kinase kinase activity|protein binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	23		Prostate(175;0.151)				GATATTAAACGTAAGTATCTTTGG	0.387													27	86	---	---	---	---					
TCF7L2	6934	broad.mit.edu	37	10	114905777	114905780	+	Frame_Shift_Del	DEL	CAAC	CAAC	-			TCGA-DH-A7UR-01A-11D-A33T-08	TCGA-DH-A7UR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f04342d6-2f32-40ec-a731-3e7bd18ffffe	bfcd7244-5a98-40a6-9328-e7fe970754e9	g.chr10:114905777_114905780delCAAC	ENST00000545257.1	+	8	1303_1306	c.796_799delCAAC	c.(796-801)cafs	p.QP266fs	TCF7L2_ENST00000352065.5_Frame_Shift_Del_p.QP243fs|TCF7L2_ENST00000369395.1_Frame_Shift_Del_p.QP291fs|TCF7L2_ENST00000369397.4_Frame_Shift_Del_p.QP243fs|TCF7L2_ENST00000536810.1_Frame_Shift_Del_p.QP266fs|TCF7L2_ENST00000349937.2_Frame_Shift_Del_p.QP262fs|TCF7L2_ENST00000369389.1_5'UTR|TCF7L2_ENST00000538897.1_Frame_Shift_Del_p.QP266fs|TCF7L2_ENST00000542695.1_5'UTR|TCF7L2_ENST00000543371.1_Frame_Shift_Del_p.QP266fs|TCF7L2_ENST00000355717.4_Frame_Shift_Del_p.QP290fs|TCF7L2_ENST00000534894.1_Frame_Shift_Del_p.QP266fs|TCF7L2_ENST00000355995.4_Frame_Shift_Del_p.QP266fs			Q9NQB0	TF7L2_HUMAN	transcription factor 7-like 2 (T-cell specific, HMG-box)	266	Mediates interaction with MAD2L2.|Pro-rich.				anti-apoptosis|blood vessel development|canonical Wnt receptor signaling pathway involved in positive regulation of epithelial to mesenchymal transition|cell cycle arrest|cell proliferation|fat cell differentiation|glucose homeostasis|maintenance of DNA repeat elements|myoblast cell fate commitment|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|pancreas development|positive regulation of heparan sulfate proteoglycan biosynthetic process|positive regulation of insulin secretion|positive regulation of protein binding|positive regulation of protein export from nucleus|positive regulation of protein kinase B signaling cascade|positive regulation of transcription from RNA polymerase II promoter|regulation of hormone metabolic process|regulation of smooth muscle cell proliferation|response to glucose stimulus	beta-catenin-TCF7L2 complex|PML body|protein-DNA complex	armadillo repeat domain binding|beta-catenin binding|gamma-catenin binding|nuclear hormone receptor binding|protein kinase binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription regulatory region DNA binding		VTI1A/TCF7L2(8)	central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(24)|liver(2)|lung(8)|ovary(1)|skin(1)	41		Breast(234;0.058)|Colorectal(252;0.0615)		Epithelial(162;0.00554)|all cancers(201;0.02)		TAGGCAAGGTCAACCAGTGTACCC	0.505			T	VTI1A	colorectal								21	243	---	---	---	---					
ARID2	196528	broad.mit.edu	37	12	46123899	46123903	+	Frame_Shift_Del	DEL	TACTT	TACTT	-			TCGA-DH-A7UR-01A-11D-A33T-08	TCGA-DH-A7UR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f04342d6-2f32-40ec-a731-3e7bd18ffffe	bfcd7244-5a98-40a6-9328-e7fe970754e9	g.chr12:46123899_46123903delTACTT	ENST00000334344.6	+	2	337_341	c.165_169delTACTT	c.(163-171)actafs	p.TTL55fs	ARID2_ENST00000422737.1_5'UTR	NM_152641.2	NP_689854.2	Q68CP9	ARID2_HUMAN	AT rich interactive domain 2 (ARID, RFX-like)	55	ARID.				chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(7)|central_nervous_system(3)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(21)|liver(20)|lung(34)|ovary(7)|pancreas(1)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	116	Lung SC(27;0.192)|Renal(347;0.236)	Lung NSC(34;0.106)|all_lung(34;0.22)	OV - Ovarian serous cystadenocarcinoma(5;0.00691)	GBM - Glioblastoma multiforme(48;0.0153)		CCAGAGTCACTACTTTAGGCGGATT	0.537			"""N, S, F"""		hepatocellular carcinoma								30	83	---	---	---	---					
NAV3	89795	broad.mit.edu	37	12	78515813	78515815	+	In_Frame_Del	DEL	ATT	ATT	-			TCGA-DH-A7UR-01A-11D-A33T-08	TCGA-DH-A7UR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f04342d6-2f32-40ec-a731-3e7bd18ffffe	bfcd7244-5a98-40a6-9328-e7fe970754e9	g.chr12:78515813_78515815delATT	ENST00000397909.2	+	16	4016_4018	c.3843_3845delATT	c.(3841-3846)aca>ac	p.TL1281del	NAV3_ENST00000536525.2_In_Frame_Del_p.TL1281del|NAV3_ENST00000228327.6_In_Frame_Del_p.TL1281del|NAV3_ENST00000266692.7_Intron			Q8IVL0	NAV3_HUMAN	neuron navigator 3	1281	Ser-rich.					nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			NS(2)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(13)|kidney(16)|large_intestine(39)|liver(2)|lung(126)|ovary(5)|pancreas(3)|prostate(6)|skin(5)|stomach(2)|upper_aerodigestive_tract(8)|urinary_tract(1)	236						CTAGTACCACATTAGCGCGGCAA	0.562										HNSCC(70;0.22)			10	80	---	---	---	---					
MYO9A	4649	broad.mit.edu	37	15	72231199	72231199	+	Frame_Shift_Del	DEL	T	T	-			TCGA-DH-A7UR-01A-11D-A33T-08	TCGA-DH-A7UR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f04342d6-2f32-40ec-a731-3e7bd18ffffe	bfcd7244-5a98-40a6-9328-e7fe970754e9	g.chr15:72231199delT	ENST00000356056.5	-	16	2844	c.2372delA	c.(2371-2373)acfs	p.N791fs	MYO9A_ENST00000566885.1_Frame_Shift_Del_p.N411fs|MYO9A_ENST00000564571.1_Frame_Shift_Del_p.N791fs|MYO9A_ENST00000563542.1_5'UTR|MYO9A_ENST00000424560.1_Frame_Shift_Del_p.N791fs|MYO9A_ENST00000444904.1_Frame_Shift_Del_p.N772fs	NM_006901.3	NP_008832.2	B2RTY4	MYO9A_HUMAN	myosin IXA	791					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction|visual perception	cytosol|integral to membrane|unconventional myosin complex	actin binding|ATP binding|GTPase activator activity|metal ion binding|motor activity			NS(4)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(29)|lung(27)|ovary(1)|pancreas(1)|prostate(5)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	88						TTACTGTTGGTTTTTTTCATT	0.303													55	67	---	---	---	---					
MLX	6945	broad.mit.edu	37	17	40722112	40722113	+	Frame_Shift_Del	DEL	CA	CA	-			TCGA-DH-A7UR-01A-11D-A33T-08	TCGA-DH-A7UR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f04342d6-2f32-40ec-a731-3e7bd18ffffe	bfcd7244-5a98-40a6-9328-e7fe970754e9	g.chr17:40722112_40722113delCA	ENST00000246912.4	+	7	804_805	c.751_752delCA	c.(751-753)gfs	p.Q251fs	MLX_ENST00000346833.4_Frame_Shift_Del_p.Q167fs|MLX_ENST00000435881.2_Frame_Shift_Del_p.Q197fs	NM_170607.2	NP_733752.1	Q9UH92	MLX_HUMAN	MLX, MAX dimerization protein	251					energy reserve metabolic process|negative regulation of transcription, DNA-dependent|positive regulation of cellular metabolic process	cytoplasm|nucleus	DNA binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|transcription factor binding			kidney(3)|large_intestine(4)|lung(1)|ovary(1)|urinary_tract(1)	10		all_cancers(22;4.26e-05)|Breast(137;0.000153)|all_epithelial(22;0.00148)		BRCA - Breast invasive adenocarcinoma(366;0.129)		TTCCCTGTTCCAGTCCTTCAAT	0.550													18	121	---	---	---	---					
SLC9B1P1	0	broad.mit.edu	37	Y	13501672	13501674	+	In_Frame_Del	DEL	AAT	AAT	-			TCGA-DH-A7UR-01A-11D-A33T-08	TCGA-DH-A7UR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	f04342d6-2f32-40ec-a731-3e7bd18ffffe	bfcd7244-5a98-40a6-9328-e7fe970754e9	g.chrY:13501672_13501674delAAT	ENST00000331172.6	-	4	534_536	c.535_537delATT	c.(535-537)del	p.I179del																								TCTTACCAACAATATTTGATTCA	0.241													3	6	---	---	---	---