Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
TBC1D2B	23102	broad.mit.edu	37	15	78290635	78290635	+	Missense_Mutation	SNP	C	C	T	rs117285325	by1000genomes	TCGA-CS-6670-01A-11D-1893-08	TCGA-CS-6670-10A-01D-1893-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	44e94c3e-4910-440b-b21e-c0fcb9d9de16	b1a2bea4-c820-4301-ad17-0605363483bd	g.chr15:78290635C>T	ENST00000409931.3	-	13	2778	c.2707G>A	c.(2707-2709)Gac>Aac	p.D903N	TBC1D2B_ENST00000300584.3_Missense_Mutation_p.R920Q|TBC1D2B_ENST00000492078.1_5'UTR			Q9UPU7	TBD2B_HUMAN	TBC1 domain family, member 2B	0						intracellular	protein binding|Rab GTPase activator activity	p.D903N(3)|p.R920Q(1)		breast(3)|cervix(2)|endometrium(4)|kidney(1)|large_intestine(7)|lung(2)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	26						GTAGGCGCGTCGGTTCCGGAT	0.617000													4	14					0	0	0.001168	0	0
LDHD	197257	broad.mit.edu	37	16	75149130	75149130	+	Missense_Mutation	SNP	C	C	T			TCGA-CS-6670-01A-11D-1893-08	TCGA-CS-6670-10A-01D-1893-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	44e94c3e-4910-440b-b21e-c0fcb9d9de16	b1a2bea4-c820-4301-ad17-0605363483bd	g.chr16:75149130C>T	ENST00000300051.4	-	3	339	c.293G>A	c.(292-294)gGc>gAc	p.G98D	LDHD_ENST00000450168.2_Missense_Mutation_p.G98D	NM_153486.3	NP_705690.2	Q86WU2	LDHD_HUMAN	lactate dehydrogenase D	98	FAD-binding PCMH-type.						D-lactate dehydrogenase (cytochrome) activity|flavin adenine dinucleotide binding|protein binding			endometrium(1)|large_intestine(2)|lung(12)|upper_aerodigestive_tract(1)	16						AAGCCCGGTGCCGGTGCCGAA	0.672000													4	133					0	0	0.009096	0	0
OR5K4	403278	broad.mit.edu	37	3	98073605	98073605	+	Missense_Mutation	SNP	G	G	A			TCGA-CS-6670-01A-11D-1893-08	TCGA-CS-6670-10A-01D-1893-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	44e94c3e-4910-440b-b21e-c0fcb9d9de16	b1a2bea4-c820-4301-ad17-0605363483bd	g.chr3:98073605G>A	ENST00000354924.2	+	1	908	c.908G>A	c.(907-909)aGg>aAg	p.R303K	RP11-325B23.2_ENST00000508616.1_lincRNA	NM_001005517.1	NP_001005517.1	A6NMS3	OR5K4_HUMAN	olfactory receptor, family 5, subfamily K, member 4	303					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(4)|lung(13)|upper_aerodigestive_tract(1)	21						AAAATTATGAGGAATTATAAC	0.249000													60	138					0	0	0.014410	0	0
FBXO38	81545	broad.mit.edu	37	5	147803622	147803622	+	Silent	SNP	T	T	C			TCGA-CS-6670-01A-11D-1893-08	TCGA-CS-6670-10A-01D-1893-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	44e94c3e-4910-440b-b21e-c0fcb9d9de16	b1a2bea4-c820-4301-ad17-0605363483bd	g.chr5:147803622T>C	ENST00000340253.5	+	13	1848	c.1680T>C	c.(1678-1680)aaT>aaC	p.N560N	FBXO38_ENST00000394370.3_Silent_p.N560N|FBXO38_ENST00000513826.1_Silent_p.N560N|FBXO38_ENST00000296701.6_Silent_p.N560N			Q6PIJ6	FBX38_HUMAN	F-box protein 38	560						cytoplasm|nucleus			ATG4C/FBXO38(2)	NS(1)|breast(2)|endometrium(7)|kidney(5)|large_intestine(9)|lung(15)|ovary(5)|prostate(2)|skin(2)|stomach(2)|urinary_tract(1)	51			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGAGTGGAAATAATACTCCAG	0.413000													6	59					0	0	0.001168	0	0
DCP1B	196513	broad.mit.edu	37	12	2062350	2062350	+	Missense_Mutation	SNP	C	C	G			TCGA-CS-6670-01A-11D-1893-08	TCGA-CS-6670-10A-01D-1893-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	44e94c3e-4910-440b-b21e-c0fcb9d9de16	b1a2bea4-c820-4301-ad17-0605363483bd	g.chr12:2062350C>G	ENST00000280665.6	-	7	835	c.756G>C	c.(754-756)caG>caC	p.Q252H	DCP1B_ENST00000397173.4_Missense_Mutation_p.Q150H|DCP1B_ENST00000541700.1_5'UTR|DCP1B_ENST00000540622.1_Missense_Mutation_p.Q126H	NM_152640.3	NP_689853.3	Q8IZD4	DCP1B_HUMAN	decapping mRNA 1B	252	Poly-Gln.				exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	cytosol|nucleus	hydrolase activity|protein binding	p.Q252H(8)		NS(1)|breast(1)|endometrium(6)|kidney(2)|large_intestine(3)|lung(10)|skin(1)	24			OV - Ovarian serous cystadenocarcinoma(31;0.00193)			gctgctgctgctgGTGGAGAG	0.552000													4	112					0	0	0.009096	0	0
CIC	23152	broad.mit.edu	37	19	42791394	42791394	+	Splice_Site	SNP	T	T	G			TCGA-CS-6670-01A-11D-1893-08	TCGA-CS-6670-10A-01D-1893-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	44e94c3e-4910-440b-b21e-c0fcb9d9de16	b1a2bea4-c820-4301-ad17-0605363483bd	g.chr19:42791394T>G	ENST00000572681.2	+	4	3247		c.e4+2		CIC_ENST00000160740.3_Splice_Site|CIC_ENST00000575354.2_Splice_Site			Q96RK0	CIC_HUMAN	capicua transcriptional repressor						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding			autonomic_ganglia(1)|breast(5)|central_nervous_system(32)|endometrium(10)|kidney(2)|large_intestine(7)|lung(9)|ovary(7)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	82		Prostate(69;0.00682)				TGATGATGCGTGAGTTCCCTG	0.652000			"""Mis, F, S"""		oligodendroglioma								3	14					0	0	0.009096	0	0
GPR85	0	broad.mit.edu	37	7	112723671	112723671	+	Missense_Mutation	SNP	A	A	G			TCGA-CS-6670-01A-11D-1893-08	TCGA-CS-6670-10A-01D-1893-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	44e94c3e-4910-440b-b21e-c0fcb9d9de16	b1a2bea4-c820-4301-ad17-0605363483bd	g.chr7:112723671A>G	ENST00000501255.2	-	3	1729	c.1106T>C	c.(1105-1107)gTt>gCt	p.V369A	GPR85_ENST00000424100.1_Missense_Mutation_p.V369A|GPR85_ENST00000297146.2_Missense_Mutation_p.V369A|GPR85_ENST00000449591.1_Missense_Mutation_p.V369A	NM_001146265.1|NM_001146266.1|NM_018970.6	NP_001139737.1|NP_001139738.1|NP_061843.3	P60893	GPR85_HUMAN	G protein-coupled receptor 85	369						integral to membrane|plasma membrane	G-protein coupled receptor activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(8)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)	17						CCCTCATATAACACAGTAAGG	0.423000													25	167					0	0	0.003330	0	0
MAGI2	9863	broad.mit.edu	37	7	77762326	77762326	+	Missense_Mutation	SNP	G	G	A	rs148526889		TCGA-CS-6670-01A-11D-1893-08	TCGA-CS-6670-10A-01D-1893-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	44e94c3e-4910-440b-b21e-c0fcb9d9de16	b1a2bea4-c820-4301-ad17-0605363483bd	g.chr7:77762326G>A	ENST00000354212.4	-	18	3336	c.3083C>T	c.(3082-3084)gCg>gTg	p.A1028V	MAGI2_ENST00000522391.1_Missense_Mutation_p.A1028V|MAGI2_ENST00000419488.1_Missense_Mutation_p.A1014V	NM_012301.3	NP_036433.2	Q86UL8	MAGI2_HUMAN	membrane associated guanylate kinase, WW and PDZ domain containing 2	1028	Pro-rich.					cell junction|synapse|synaptosome	phosphatase binding			NS(1)|breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(12)|lung(37)|ovary(5)|prostate(1)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(3)	84		all_cancers(73;0.0064)|all_epithelial(88;0.087)|all_neural(109;0.0936)|Medulloblastoma(109;0.166)|Melanoma(862;0.236)				ACTCTGCTGCGCCATGGGACT	0.622000													5	236					0	0	0.000602	0	0
WDR49	151790	broad.mit.edu	37	3	167246909	167246909	+	Silent	SNP	A	A	G			TCGA-CS-6670-01A-11D-1893-08	TCGA-CS-6670-10A-01D-1893-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	44e94c3e-4910-440b-b21e-c0fcb9d9de16	b1a2bea4-c820-4301-ad17-0605363483bd	g.chr3:167246909A>G	ENST00000308378.3	-	10	1586	c.1281T>C	c.(1279-1281)tcT>tcC	p.S427S	WDR49_ENST00000479765.1_Intron|WDR49_ENST00000453925.2_Silent_p.S491S|WDR49_ENST00000476376.1_Silent_p.S252S	NM_178824.3	NP_849146.1	Q8IV35	WDR49_HUMAN	WD repeat domain 49	427										breast(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(28)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	50						TCTTATCAGTAGACATAATAA	0.353000													11	44					0	0	0.008291	0	0
CECR2	27443	broad.mit.edu	37	22	18020229	18020229	+	Missense_Mutation	SNP	C	C	T			TCGA-CS-6670-01A-11D-1893-08	TCGA-CS-6670-10A-01D-1893-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	44e94c3e-4910-440b-b21e-c0fcb9d9de16	b1a2bea4-c820-4301-ad17-0605363483bd	g.chr22:18020229C>T	ENST00000262608.8	+	13	1561	c.1561C>T	c.(1561-1563)Cgg>Tgg	p.R521W	CECR2_ENST00000400573.4_Missense_Mutation_p.R520W|CECR2_ENST00000400585.2_Missense_Mutation_p.R379W	NM_031413.3	NP_113601.2	Q9BXF3	CECR2_HUMAN	cat eye syndrome chromosome region, candidate 2	562	Bromo.				chromatin modification|cytokinesis|cytoskeleton organization|DNA fragmentation involved in apoptotic nuclear change|vesicle-mediated transport		protein binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(22)|ovary(1)|pancreas(1)|prostate(2)|skin(5)|stomach(1)|urinary_tract(1)	59		all_epithelial(15;0.139)		Lung(27;0.146)		GGAGAAAAGACGGAGTCGGGC	0.527000													6	36					0	0	0.001168	0	0
FOSL2	2355	broad.mit.edu	37	2	28627127	28627127	+	Missense_Mutation	SNP	C	C	T			TCGA-CS-6670-01A-11D-1893-08	TCGA-CS-6670-10A-01D-1893-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	44e94c3e-4910-440b-b21e-c0fcb9d9de16	b1a2bea4-c820-4301-ad17-0605363483bd	g.chr2:28627127C>T	ENST00000264716.4	+	2	1119	c.256C>T	c.(256-258)Ccg>Tcg	p.P86S	FOSL2_ENST00000545753.1_Missense_Mutation_p.P47S|FOSL2_ENST00000460736.1_3'UTR|FOSL2_ENST00000379619.1_Missense_Mutation_p.P61S	NM_005253.3	NP_005244.1	P15408	FOSL2_HUMAN	FOS-like antigen 2	86					cell death|regulation of transcription from RNA polymerase II promoter	nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(1)|large_intestine(3)|lung(1)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	14	Acute lymphoblastic leukemia(172;0.155)					CAGCCCCCTGCCGGGCCTGGC	0.647000													4	138					0	0	0.000602	0	0
OR5H14	403273	broad.mit.edu	37	3	97868884	97868884	+	Missense_Mutation	SNP	A	A	G			TCGA-CS-6670-01A-11D-1893-08	TCGA-CS-6670-10A-01D-1893-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	44e94c3e-4910-440b-b21e-c0fcb9d9de16	b1a2bea4-c820-4301-ad17-0605363483bd	g.chr3:97868884A>G	ENST00000437310.1	+	1	715	c.655A>G	c.(655-657)Ata>Gta	p.I219V		NM_001005514.1	NP_001005514.1	A6NHG9	O5H14_HUMAN	olfactory receptor, family 5, subfamily H, member 14	219					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(2)|endometrium(3)|kidney(1)|large_intestine(3)|lung(17)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	31						TATATCTTACATATTTGTCCT	0.318000													23	34					0	0	0.002780	0	0
IGHV4-28	0	broad.mit.edu	37	14	106780540	106780540	+	RNA	SNP	C	C	T			TCGA-CS-6670-01A-11D-1893-08	TCGA-CS-6670-10A-01D-1893-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	44e94c3e-4910-440b-b21e-c0fcb9d9de16	b1a2bea4-c820-4301-ad17-0605363483bd	g.chr14:106780540C>T	ENST00000390612.2	-	0	395																											CGGCCGTGTCCACGGCGGTCA	0.597000													5	368					0	0	0.006214	0	0
TTN	7273	broad.mit.edu	37	2	179589234	179589234	+	Silent	SNP	C	C	T			TCGA-CS-6670-01A-11D-1893-08	TCGA-CS-6670-10A-01D-1893-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	44e94c3e-4910-440b-b21e-c0fcb9d9de16	b1a2bea4-c820-4301-ad17-0605363483bd	g.chr2:179589234C>T	ENST00000589042.1	-	72	21092	c.20868G>A	c.(20866-20868)ccG>ccA	p.P6956P	TTN_ENST00000591111.1_Silent_p.P6639P|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron|RP11-171I2.1_ENST00000590024.1_RNA|TTN_ENST00000342992.6_Silent_p.P5712P|TTN_ENST00000359218.5_Intron|TTN_ENST00000342175.6_Intron	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	6639	Ig-like 51.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCACCGTCATCGGTCCTGCCT	0.478000													16	36					0	0	0.004990	0	0
PGLYRP1	8993	broad.mit.edu	37	19	46526067	46526067	+	Silent	SNP	G	G	A			TCGA-CS-6670-01A-11D-1893-08	TCGA-CS-6670-10A-01D-1893-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	44e94c3e-4910-440b-b21e-c0fcb9d9de16	b1a2bea4-c820-4301-ad17-0605363483bd	g.chr19:46526067G>A	ENST00000008938.4	-	1	256	c.213C>T	c.(211-213)gcC>gcT	p.A71A		NM_005091.2	NP_005082.1	O75594	PGRP1_HUMAN	peptidoglycan recognition protein 1	71					defense response to Gram-positive bacterium|detection of bacterium|innate immune response|peptidoglycan catabolic process	extracellular region	bacterial cell surface binding|N-acetylmuramoyl-L-alanine amidase activity|peptidoglycan receptor activity|zinc ion binding			endometrium(2)|large_intestine(3)|lung(3)|ovary(2)	10		all_neural(266;0.113)|Ovarian(192;0.127)		OV - Ovarian serous cystadenocarcinoma(262;0.0036)|GBM - Glioblastoma multiforme(486;0.022)|Epithelial(262;0.208)		GCTGGCACGAGGCGGGGGTGT	0.652000													9	22					0	0	0.004482	0	0
ATP9A	10079	broad.mit.edu	37	20	50256040	50256040	+	Missense_Mutation	SNP	C	C	T			TCGA-CS-6670-01A-11D-1893-08	TCGA-CS-6670-10A-01D-1893-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	44e94c3e-4910-440b-b21e-c0fcb9d9de16	b1a2bea4-c820-4301-ad17-0605363483bd	g.chr20:50256040C>T	ENST00000338821.5	-	15	1774	c.1510G>A	c.(1510-1512)Gcc>Acc	p.A504T	ATP9A_ENST00000402822.1_Missense_Mutation_p.A383T|ATP9A_ENST00000311637.5_Missense_Mutation_p.A368T	NM_006045.1	NP_006036.1	O75110	ATP9A_HUMAN	ATPase, class II, type 9A	504					ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			breast(2)|cervix(2)|endometrium(6)|kidney(1)|large_intestine(10)|lung(18)|ovary(5)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	48						TGTACCAGGGCCACCTAAACA	0.567000											OREG0026043	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	11	44					0	0	0.008291	0	0
SPATA31E1	286234	broad.mit.edu	37	9	90501369	90501369	+	Missense_Mutation	SNP	C	C	T			TCGA-CS-6670-01A-11D-1893-08	TCGA-CS-6670-10A-01D-1893-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	44e94c3e-4910-440b-b21e-c0fcb9d9de16	b1a2bea4-c820-4301-ad17-0605363483bd	g.chr9:90501369C>T	ENST00000325643.5	+	4	2033	c.1967C>T	c.(1966-1968)cCt>cTt	p.P656L		NM_178828.4	NP_849150.3			SPATA31 subfamily E, member 1																		CTGCTACAGCCTGATGGGGAA	0.622000													11	68					0	0	0.010729	0	0
IGSF9	57549	broad.mit.edu	37	1	159900616	159900616	+	Missense_Mutation	SNP	A	A	G			TCGA-CS-6670-01A-11D-1893-08	TCGA-CS-6670-10A-01D-1893-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	44e94c3e-4910-440b-b21e-c0fcb9d9de16	b1a2bea4-c820-4301-ad17-0605363483bd	g.chr1:159900616A>G	ENST00000368094.1	-	14	1876	c.1679T>C	c.(1678-1680)tTg>tCg	p.L560S	IGSF9_ENST00000361509.3_Missense_Mutation_p.L544S|IGSF9_ENST00000493195.1_5'UTR	NM_001135050.1	NP_001128522.1	Q9P2J2	TUTLA_HUMAN	immunoglobulin superfamily, member 9	560	Fibronectin type-III 1.					cell junction|integral to membrane|synapse				central_nervous_system(2)|endometrium(8)|kidney(3)|large_intestine(13)|lung(17)|ovary(3)|prostate(4)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	56	all_hematologic(112;0.0597)	Breast(1374;0.000126)	BRCA - Breast invasive adenocarcinoma(70;0.111)			AGGCACTGCCAAGGACACCCA	0.617000													10	38					0	0	0.006214	0	0
PCDHGA2	0	broad.mit.edu	37	5	140720793	140720793	+	Missense_Mutation	SNP	C	C	G			TCGA-CS-6670-01A-11D-1893-08	TCGA-CS-6670-10A-01D-1893-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	44e94c3e-4910-440b-b21e-c0fcb9d9de16	b1a2bea4-c820-4301-ad17-0605363483bd	g.chr5:140720793C>G	ENST00000394576.2	+	1	2255	c.2255C>G	c.(2254-2256)aCc>aGc	p.T752S	PCDHGA1_ENST00000517417.1_Intron	NM_018915.2	NP_061738.1														breast(3)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(20)|lung(32)|ovary(1)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	77			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TTCCTGCAGACCTATTCCCAC	0.612000													20	131					0	0	0.009535	0	0
WASH3P	0	broad.mit.edu	37	15	102515335	102515335	+	RNA	SNP	C	C	G			TCGA-CS-6670-01A-11D-1893-08	TCGA-CS-6670-10A-01D-1893-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	44e94c3e-4910-440b-b21e-c0fcb9d9de16	b1a2bea4-c820-4301-ad17-0605363483bd	g.chr15:102515335C>G	ENST00000557932.1	+	0	1181																		p.L386V(3)		central_nervous_system(1)|endometrium(6)|kidney(11)|prostate(5)|stomach(1)|urinary_tract(1)	25						GGAGCGAAAGCTGGAGAAGAA	0.652000													3	46					0	0	0.009096	0	0
IDH1	3417	broad.mit.edu	37	2	209113112	209113112	+	Missense_Mutation	SNP	C	C	T	rs121913500		TCGA-CS-6670-01A-11D-1893-08	TCGA-CS-6670-10A-01D-1893-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	44e94c3e-4910-440b-b21e-c0fcb9d9de16	b1a2bea4-c820-4301-ad17-0605363483bd	g.chr2:209113112C>T	ENST00000415913.1	-	4	776	c.395G>A	c.(394-396)cGt>cAt	p.R132H	IDH1_ENST00000345146.2_Missense_Mutation_p.R132H|IDH1_ENST00000446179.1_Missense_Mutation_p.R132H			O75874	IDHC_HUMAN	isocitrate dehydrogenase 1 (NADP+), soluble	132			R -> C (in colorectal cancer and glioma samples; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha- ketoglutarate but instead alpha- ketoglutarate is converted to R(-)-2- hydroxyglutarate).|R -> G (in a glioma sample; glioblastoma multiforme; somatic mutation).|R -> H (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> L (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> S (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).		2-oxoglutarate metabolic process|cellular lipid metabolic process|glyoxylate cycle|isocitrate metabolic process|NADPH regeneration|tricarboxylic acid cycle	cytosol|peroxisomal matrix	isocitrate dehydrogenase (NADP+) activity|magnesium ion binding|NAD binding|protein homodimerization activity	p.R132H(2774)|p.R132L(59)|p.R132V(1)|p.G131_R132>VL(1)		NS(1)|autonomic_ganglia(2)|biliary_tract(24)|bone(237)|central_nervous_system(3764)|endometrium(3)|haematopoietic_and_lymphoid_tissue(794)|kidney(2)|large_intestine(7)|lung(7)|prostate(6)|skin(5)|soft_tissue(12)|thyroid(22)|urinary_tract(1)	4887				Epithelial(149;0.0322)|LUSC - Lung squamous cell carcinoma(261;0.0711)|Lung(261;0.136)		ATAAGCATGACGACCTATGAT	0.393000			Mis		gliobastoma								32	45					0	0	0.012213	0	0
C17orf53	78995	broad.mit.edu	37	17	42231994	42231994	+	Missense_Mutation	SNP	G	G	A			TCGA-CS-6670-01A-11D-1893-08	TCGA-CS-6670-10A-01D-1893-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	44e94c3e-4910-440b-b21e-c0fcb9d9de16	b1a2bea4-c820-4301-ad17-0605363483bd	g.chr17:42231994G>A	ENST00000319977.4	+	6	1760	c.1523G>A	c.(1522-1524)aGc>aAc	p.S508N	C17orf53_ENST00000245382.6_Missense_Mutation_p.S432N|C17orf53_ENST00000585683.1_Missense_Mutation_p.S507N	NM_001171251.1|NM_024032.3	NP_001164722.1|NP_076937.2	Q8N3J3	CQ053_HUMAN	chromosome 17 open reading frame 53	508										NS(1)|breast(3)|cervix(1)|kidney(3)|large_intestine(3)|lung(8)|ovary(1)|skin(1)|urinary_tract(1)	22		Breast(137;0.0364)|Prostate(33;0.0376)		BRCA - Breast invasive adenocarcinoma(366;0.114)		CTGACTCGGAGCACAATGGAC	0.552000													12	102					0	0	0.001855	0	0
MATK	4145	broad.mit.edu	37	19	3783831	3783831	+	Missense_Mutation	SNP	T	T	C			TCGA-CS-6670-01A-11D-1893-08	TCGA-CS-6670-10A-01D-1893-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	44e94c3e-4910-440b-b21e-c0fcb9d9de16	b1a2bea4-c820-4301-ad17-0605363483bd	g.chr19:3783831T>C	ENST00000310132.6	-	6	961	c.563A>G	c.(562-564)aAc>aGc	p.N188S	MATK_ENST00000585778.1_Missense_Mutation_p.N188S|MATK_ENST00000395045.2_Missense_Mutation_p.N189S|MATK_ENST00000395040.2_Missense_Mutation_p.N147S	NM_139355.2	NP_647612.1	P42679	MATK_HUMAN	megakaryocyte-associated tyrosine kinase	188	SH2.				cell proliferation|mesoderm development|positive regulation of cell proliferation	cytoplasm|nucleus	ATP binding|non-membrane spanning protein tyrosine kinase activity			central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(13)|ovary(1)|skin(2)|stomach(2)|urinary_tract(1)	26		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00461)|STAD - Stomach adenocarcinoma(1328;0.18)		GTCCATGAGGTTGCAGAAGAA	0.637000													6	47					0	0	0.001984	0	0
PTPN4	5775	broad.mit.edu	37	2	120718482	120718482	+	Missense_Mutation	SNP	G	G	A			TCGA-CS-6670-01A-11D-1893-08	TCGA-CS-6670-10A-01D-1893-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	44e94c3e-4910-440b-b21e-c0fcb9d9de16	b1a2bea4-c820-4301-ad17-0605363483bd	g.chr2:120718482G>A	ENST00000263708.2	+	23	3004	c.2233G>A	c.(2233-2235)Ggc>Agc	p.G745S	PTPN4_ENST00000544261.1_Missense_Mutation_p.G378S	NM_002830.3	NP_002821.1	P29074	PTN4_HUMAN	protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte)	745	Tyrosine-protein phosphatase.					cytoplasm|cytoskeleton|internal side of plasma membrane	cytoskeletal protein binding|non-membrane spanning protein tyrosine phosphatase activity	p.G745S(1)		endometrium(3)|kidney(2)|large_intestine(7)|lung(15)|ovary(2)|urinary_tract(1)	30					Alendronate(DB00630)	TTGGGAACAAGGCTCCTCTAT	0.393000													55	83					0	0	0.014410	0	0
TUBB8P7	0	broad.mit.edu	37	16	90162379	90162379	+	RNA	SNP	A	A	G			TCGA-CS-6670-01A-11D-1893-08	TCGA-CS-6670-10A-01D-1893-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	44e94c3e-4910-440b-b21e-c0fcb9d9de16	b1a2bea4-c820-4301-ad17-0605363483bd	g.chr16:90162379A>G	ENST00000567960.1	+	0	1115				TUBB8P7_ENST00000564451.1_RNA																							TGGGAATAATACGGCCATCCA	0.522000													5	187					0	0	0.000602	0	0
CXCR2	3579	broad.mit.edu	37	2	218999633	218999633	+	Missense_Mutation	SNP	G	G	A	rs75759064	by1000genomes	TCGA-CS-6670-01A-11D-1893-08	TCGA-CS-6670-10A-01D-1893-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	44e94c3e-4910-440b-b21e-c0fcb9d9de16	b1a2bea4-c820-4301-ad17-0605363483bd	g.chr2:218999633G>A	ENST00000318507.2	+	3	536	c.109G>A	c.(109-111)Gcc>Acc	p.A37T		NM_001557.3	NP_001548.1	P25025	CXCR2_HUMAN	chemokine (C-X-C motif) receptor 2	37					activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|cellular defense response|dendritic cell chemotaxis|inflammatory response|neutrophil activation|neutrophil chemotaxis|positive regulation of cell proliferation	cell surface|integral to plasma membrane|mast cell granule	interleukin-8 receptor activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(11)|skin(1)|stomach(1)	22						ACTAGATGCCGCCCCATGTGA	0.448000													7	212					0	0	0.001984	0	0
IGF2R	3482	broad.mit.edu	37	6	160497010	160497010	+	Silent	SNP	T	T	C			TCGA-CS-6670-01A-11D-1893-08	TCGA-CS-6670-10A-01D-1893-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	44e94c3e-4910-440b-b21e-c0fcb9d9de16	b1a2bea4-c820-4301-ad17-0605363483bd	g.chr6:160497010T>C	ENST00000356956.1	+	36	5446	c.5298T>C	c.(5296-5298)tgT>tgC	p.C1766C		NM_000876.2	NP_000867.2	P11717	MPRI_HUMAN	insulin-like growth factor 2 receptor	1766					receptor-mediated endocytosis	cell surface|endocytic vesicle|endosome|integral to plasma membrane|lysosomal membrane|trans-Golgi network transport vesicle	glycoprotein binding|insulin-like growth factor receptor activity|phosphoprotein binding|transporter activity			breast(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(27)|lung(31)|ovary(3)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	95		Breast(66;0.000777)|Ovarian(120;0.0305)		OV - Ovarian serous cystadenocarcinoma(65;2.45e-17)|BRCA - Breast invasive adenocarcinoma(81;1.09e-05)		CGTTTCACTGTAAGAGAGGTG	0.468000													21	159					0	0	0.010504	0	0
CUL4B	8450	broad.mit.edu	37	X	119691896	119691896	+	Splice_Site	SNP	T	T	C			TCGA-CS-6670-01A-11D-1893-08	TCGA-CS-6670-10A-01D-1893-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	44e94c3e-4910-440b-b21e-c0fcb9d9de16	b1a2bea4-c820-4301-ad17-0605363483bd	g.chrX:119691896T>C	ENST00000371322.5	-	2	618		c.e2-2		CUL4B_ENST00000404115.3_Splice_Site|CUL4B_ENST00000336592.6_Splice_Site	NM_001079872.1	NP_001073341.1	Q13620	CUL4B_HUMAN	cullin 4B						cell cycle|DNA repair|ubiquitin-dependent protein catabolic process	Cul4B-RING ubiquitin ligase complex|nucleus	protein binding|ubiquitin protein ligase binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(7)|lung(14)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	36						TAGGCTTATCTAGATGATATG	0.313000													11	14					0	0	0.013537	0	0
COBL	23242	broad.mit.edu	37	7	51096959	51096959	+	Missense_Mutation	SNP	G	G	A			TCGA-CS-6670-01A-11D-1893-08	TCGA-CS-6670-10A-01D-1893-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	44e94c3e-4910-440b-b21e-c0fcb9d9de16	b1a2bea4-c820-4301-ad17-0605363483bd	g.chr7:51096959G>A	ENST00000395542.2	-	12	2264	c.2080C>T	c.(2080-2082)Cgt>Tgt	p.R694C	COBL_ENST00000265136.7_Missense_Mutation_p.R612C			O75128	COBL_HUMAN	cordon-bleu WH2 repeat protein	612								p.R612C(1)		NS(2)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(10)|lung(26)|ovary(3)|prostate(4)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	65	Glioma(55;0.08)					AAGGCCACACGGATTCCTTTT	0.527000													20	100					0	0	0.010504	0	0
SPATA9	83890	broad.mit.edu	37	5	94994605	94994605	+	Missense_Mutation	SNP	T	T	C			TCGA-CS-6670-01A-11D-1893-08	TCGA-CS-6670-10A-01D-1893-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	44e94c3e-4910-440b-b21e-c0fcb9d9de16	b1a2bea4-c820-4301-ad17-0605363483bd	g.chr5:94994605T>C	ENST00000274432.8	-	5	628	c.487A>G	c.(487-489)Aat>Gat	p.N163D	RFESD_ENST00000508206.1_Intron|SPATA9_ENST00000477047.2_5'UTR	NM_031952.3	NP_114158.2	Q9BWV2	SPAT9_HUMAN	spermatogenesis associated 9	163					cell differentiation|multicellular organismal development|spermatogenesis	integral to membrane				large_intestine(3)|lung(4)	7		all_cancers(142;1.28e-06)|all_epithelial(76;1.55e-09)|all_lung(232;0.00307)|Lung NSC(167;0.00452)|Ovarian(225;0.00473)|Colorectal(57;0.0846)|Breast(839;0.198)		all cancers(79;8.91e-16)		AGCACAGCATTAACACAGACT	0.348000													21	85					0	0	0.014323	0	0
DBT	1629	broad.mit.edu	37	1	100696303	100696303	+	Missense_Mutation	SNP	G	G	A			TCGA-CS-6670-01A-11D-1893-08	TCGA-CS-6670-10A-01D-1893-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	44e94c3e-4910-440b-b21e-c0fcb9d9de16	b1a2bea4-c820-4301-ad17-0605363483bd	g.chr1:100696303G>A	ENST00000370132.3	-	4	432	c.419C>T	c.(418-420)aCg>aTg	p.T140M	DBT_ENST00000370131.3_Missense_Mutation_p.T140M	NM_001918.3	NP_001909.3	P11182	ODB2_HUMAN	dihydrolipoamide branched chain transacylase E2	140					branched chain family amino acid catabolic process|fatty-acyl-CoA biosynthetic process	microtubule cytoskeleton|mitochondrial alpha-ketoglutarate dehydrogenase complex|mitochondrial nucleoid	acyltransferase activity|cofactor binding|dihydrolipoyllysine-residue (2-methylpropanoyl)transferase activity|protein binding			NS(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(11)|pancreas(1)|prostate(1)|skin(1)	19		all_epithelial(167;5.4e-06)|all_lung(203;0.00125)|Lung NSC(277;0.00131)		Epithelial(280;0.0739)|all cancers(265;0.123)|COAD - Colon adenocarcinoma(174;0.154)|Lung(183;0.199)		TAAAGCTTCCGTTTCTATGTC	0.328000													14	21					0	0	0.002450	0	0
ZBED4	9889	broad.mit.edu	37	22	50280050	50280050	+	Missense_Mutation	SNP	G	G	A	rs55681922		TCGA-CS-6670-01A-11D-1893-08	TCGA-CS-6670-10A-01D-1893-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	44e94c3e-4910-440b-b21e-c0fcb9d9de16	b1a2bea4-c820-4301-ad17-0605363483bd	g.chr22:50280050G>A	ENST00000216268.4	+	2	3217	c.2740G>A	c.(2740-2742)Gtc>Atc	p.V914I		NM_014838.2	NP_055653.2	O75132	ZBED4_HUMAN	zinc finger, BED-type containing 4	914						cytoplasm|nucleus	DNA binding|metal ion binding|protein dimerization activity			breast(2)|endometrium(3)|kidney(2)|large_intestine(11)|lung(20)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)	44		all_cancers(38;8.58e-10)|all_epithelial(38;1.15e-08)|all_lung(38;0.000109)|Lung NSC(38;0.0018)|Breast(42;0.00191)|Ovarian(80;0.0164)|Lung SC(80;0.164)		UCEC - Uterine corpus endometrioid carcinoma (28;0.168)|BRCA - Breast invasive adenocarcinoma(115;0.2)|LUAD - Lung adenocarcinoma(64;0.247)		CGAGATGTCCGTCGAGTGTAA	0.582000													13	62					0	0	0.002450	0	0
NPY1R	0	broad.mit.edu	37	4	164246627	164246627	+	Missense_Mutation	SNP	T	T	C			TCGA-CS-6670-01A-11D-1893-08	TCGA-CS-6670-10A-01D-1893-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	44e94c3e-4910-440b-b21e-c0fcb9d9de16	b1a2bea4-c820-4301-ad17-0605363483bd	g.chr4:164246627T>C	ENST00000296533.2	-	3	1514	c.983A>G	c.(982-984)cAg>cGg	p.Q328R	NPY1R_ENST00000509586.1_Missense_Mutation_p.Q85R	NM_000909.5	NP_000900.1	P25929	NPY1R_HUMAN	neuropeptide Y receptor Y1	328					inhibition of adenylate cyclase activity by G-protein signaling pathway|outflow tract morphogenesis	integral to plasma membrane	protein binding			breast(1)|cervix(1)|large_intestine(4)|lung(18)|pancreas(1)|skin(1)|upper_aerodigestive_tract(4)	30	all_hematologic(180;0.166)	Prostate(90;0.0959)|all_neural(102;0.223)				CAAGTCTCTCTGGAAGTTTTT	0.428000													25	95					0	0	0.003330	0	0
FRG1B	0	broad.mit.edu	37	20	29628263	29628263	+	Missense_Mutation	SNP	A	A	G			TCGA-CS-6670-01A-11D-1893-08	TCGA-CS-6670-10A-01D-1893-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	44e94c3e-4910-440b-b21e-c0fcb9d9de16	b1a2bea4-c820-4301-ad17-0605363483bd	g.chr20:29628263A>G	ENST00000278882.3	+	6	645	c.265A>G	c.(265-267)Att>Gtt	p.I89V	FRG1B_ENST00000358464.4_Missense_Mutation_p.I89V|FRG1B_ENST00000439954.2_Missense_Mutation_p.I94V														p.I89V(4)		endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						TAGCTGCTTTATTAGATGCAA	0.363000													6	86					0	0	0.003080	0	0
MYO3B	140469	broad.mit.edu	37	2	171264279	171264279	+	Missense_Mutation	SNP	G	G	A			TCGA-CS-6670-01A-11D-1893-08	TCGA-CS-6670-10A-01D-1893-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	44e94c3e-4910-440b-b21e-c0fcb9d9de16	b1a2bea4-c820-4301-ad17-0605363483bd	g.chr2:171264279G>A	ENST00000334231.6	+	22	2602	c.2602G>A	c.(2602-2604)Gat>Aat	p.D868N	MYO3B_ENST00000409044.3_Missense_Mutation_p.D859N|MYO3B_ENST00000408978.4_Missense_Mutation_p.D859N|MYO3B_ENST00000602629.1_3'UTR			Q8WXR4	MYO3B_HUMAN	myosin IIIB	859	Myosin head-like.				response to stimulus|visual perception	cytoplasm|myosin complex	actin binding|ATP binding|motor activity|protein serine/threonine kinase activity			breast(1)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(25)|ovary(6)|pancreas(1)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	59						TCTCCCTGCCGATGTGGTTGT	0.463000													6	184					0	0	0.001984	0	0
LRRIQ1	84125	broad.mit.edu	37	12	85518209	85518209	+	Missense_Mutation	SNP	A	A	G			TCGA-CS-6670-01A-11D-1893-08	TCGA-CS-6670-10A-01D-1893-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	44e94c3e-4910-440b-b21e-c0fcb9d9de16	b1a2bea4-c820-4301-ad17-0605363483bd	g.chr12:85518209A>G	ENST00000393217.2	+	17	3980	c.3919A>G	c.(3919-3921)Att>Gtt	p.I1307V		NM_001079910.1	NP_001073379.1	Q96JM4	LRIQ1_HUMAN	leucine-rich repeats and IQ motif containing 1	1307										breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(21)|liver(1)|lung(28)|ovary(5)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)	83				GBM - Glioblastoma multiforme(134;0.212)		GGCAAGCAGTATTCCCACCAT	0.373000													7	320					0	0	0.004482	0	0
EHHADH	1962	broad.mit.edu	37	3	184910182	184910182	+	Silent	SNP	G	G	A			TCGA-CS-6670-01A-11D-1893-08	TCGA-CS-6670-10A-01D-1893-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	44e94c3e-4910-440b-b21e-c0fcb9d9de16	b1a2bea4-c820-4301-ad17-0605363483bd	g.chr3:184910182G>A	ENST00000231887.3	-	7	2079	c.2004C>T	c.(2002-2004)tcC>tcT	p.S668S	EHHADH_ENST00000456310.1_Silent_p.S572S	NM_001166415.1|NM_001966.3	NP_001159887.1|NP_001957.2	Q08426	ECHP_HUMAN	enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase	668						peroxisome	3-hydroxyacyl-CoA dehydrogenase activity|coenzyme binding|dodecenoyl-CoA delta-isomerase activity|enoyl-CoA hydratase activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(9)|ovary(3)|prostate(2)|skin(3)	24	all_cancers(143;4.04e-11)|Ovarian(172;0.0339)|Breast(254;0.247)		Epithelial(37;1.98e-32)|OV - Ovarian serous cystadenocarcinoma(80;5.55e-21)		NADH(DB00157)	ACCCAACTGTGGAAGCATAGA	0.473000													4	71					0	0	0.009096	0	0
LATS2	26524	broad.mit.edu	37	13	21549263	21549263	+	Missense_Mutation	SNP	C	C	T			TCGA-CS-6670-01A-11D-1893-08	TCGA-CS-6670-10A-01D-1893-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	44e94c3e-4910-440b-b21e-c0fcb9d9de16	b1a2bea4-c820-4301-ad17-0605363483bd	g.chr13:21549263C>T	ENST00000382592.4	-	8	3418	c.3013G>A	c.(3013-3015)Gta>Ata	p.V1005I	LATS2_ENST00000542899.1_Missense_Mutation_p.V1005I	NM_014572.2	NP_055387.2	Q9NRM7	LATS2_HUMAN	large tumor suppressor kinase 2	1005	AGC-kinase C-terminal.				cell division|G1/S transition of mitotic cell cycle|hippo signaling cascade|hormone-mediated signaling pathway|intracellular protein kinase cascade|mitosis|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cyclin-dependent protein kinase activity	microtubule organizing center|nucleus|spindle pole	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			breast(4)|central_nervous_system(3)|endometrium(2)|kidney(2)|large_intestine(7)|lung(19)|ovary(3)|pancreas(1)|prostate(2)|urinary_tract(2)	45		all_cancers(29;4.74e-22)|all_epithelial(30;1.45e-18)|all_lung(29;4.69e-16)|Lung SC(185;0.0262)|Hepatocellular(188;0.244)		all cancers(112;0.000781)|Epithelial(112;0.00144)|OV - Ovarian serous cystadenocarcinoma(117;0.0183)|Lung(94;0.0375)|LUSC - Lung squamous cell carcinoma(192;0.104)		TCTTCATCTACGGGGTCGAAA	0.557000													32	154					0	0	0.013726	0	0
ATG2A	23130	broad.mit.edu	37	11	64674138	64674138	+	Splice_Site	SNP	T	T	C			TCGA-CS-6670-01A-11D-1893-08	TCGA-CS-6670-10A-01D-1893-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	44e94c3e-4910-440b-b21e-c0fcb9d9de16	b1a2bea4-c820-4301-ad17-0605363483bd	g.chr11:64674138T>C	ENST00000421419.2	-	20	3096	c.2983_splice	c.e20+1	p.R994_splice	ATG2A_ENST00000377264.3_Splice_Site_p.R994_splice			Q2TAZ0	ATG2A_HUMAN	autophagy related 2A	994							protein binding			breast(3)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(19)|ovary(3)|prostate(5)|skin(1)|stomach(1)|urinary_tract(3)	55						GCCTCACACCTCGGTGGTAGA	0.617000													13	112					0	0	0.001855	0	0
URB2	9816	broad.mit.edu	37	1	229773892	229773892	+	Missense_Mutation	SNP	G	G	A			TCGA-CS-6670-01A-11D-1893-08	TCGA-CS-6670-10A-01D-1893-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	44e94c3e-4910-440b-b21e-c0fcb9d9de16	b1a2bea4-c820-4301-ad17-0605363483bd	g.chr1:229773892G>A	ENST00000258243.2	+	4	3668	c.3532G>A	c.(3532-3534)Gcc>Acc	p.A1178T		NM_014777.2	NP_055592.2	Q14146	URB2_HUMAN	URB2 ribosome biogenesis 2 homolog (S. cerevisiae)	1178						nucleolus				breast(1)|central_nervous_system(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(33)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(6)	73						TTTTCAGGCAGCCTTGCAGTT	0.498000													27	89					0	0	0.005443	0	0
KIAA0947	23379	broad.mit.edu	37	5	5466481	5466481	+	Nonsense_Mutation	SNP	C	C	G			TCGA-CS-6670-01A-11D-1893-08	TCGA-CS-6670-10A-01D-1893-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	44e94c3e-4910-440b-b21e-c0fcb9d9de16	b1a2bea4-c820-4301-ad17-0605363483bd	g.chr5:5466481C>G	ENST00000296564.7	+	14	6149	c.5927C>G	c.(5926-5928)tCa>tGa	p.S1976*		NM_015325.2	NP_056140.1	Q9Y2F5	K0947_HUMAN	KIAA0947	1976										breast(2)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(14)|ovary(1)|prostate(4)|upper_aerodigestive_tract(1)	35						TCTATTCTCTCAGAACTAAAA	0.388000													7	58					0	0	0.001984	0	0
SP110	3431	broad.mit.edu	37	2	231036817	231036817	+	Missense_Mutation	SNP	T	T	C			TCGA-CS-6670-01A-11D-1893-08	TCGA-CS-6670-10A-01D-1893-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	44e94c3e-4910-440b-b21e-c0fcb9d9de16	b1a2bea4-c820-4301-ad17-0605363483bd	g.chr2:231036817T>C	ENST00000258381.6	-	16	1857	c.1780A>G	c.(1780-1782)Acc>Gcc	p.T594A	SP110_ENST00000358662.4_Missense_Mutation_p.T594A|AC009950.2_ENST00000594622.1_RNA	NM_080424.2	NP_536349.2	Q9HB58	SP110_HUMAN	SP110 nuclear body protein	594	Bromo.				interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|signal transducer activity|zinc ion binding			breast(4)|endometrium(3)|large_intestine(5)|lung(8)|ovary(2)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	29		Renal(207;0.0112)|all_lung(227;0.0223)|Lung NSC(271;0.0983)|all_hematologic(139;0.104)|Acute lymphoblastic leukemia(138;0.169)		Epithelial(121;2.61e-12)|all cancers(144;6.39e-10)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.0097)		CTCTCCAGGGTCTTAGATACA	0.522000													5	159					0	0	0.000602	0	0
KRT5	3852	broad.mit.edu	37	12	52913647	52913647	+	Missense_Mutation	SNP	A	A	G			TCGA-CS-6670-01A-11D-1893-08	TCGA-CS-6670-10A-01D-1893-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	44e94c3e-4910-440b-b21e-c0fcb9d9de16	b1a2bea4-c820-4301-ad17-0605363483bd	g.chr12:52913647A>G	ENST00000252242.4	-	1	824	c.434T>C	c.(433-435)gTc>gCc	p.V145A		NM_000424.3	NP_000415.2	P13647	K2C5_HUMAN	keratin 5	145	Head.				epidermis development|hemidesmosome assembly	cytosol|keratin filament	protein binding|structural constituent of cytoskeleton			endometrium(5)|kidney(1)|large_intestine(8)|lung(15)|prostate(4)|skin(2)	35				BRCA - Breast invasive adenocarcinoma(357;0.189)		ACTCTGGTTGACAGTGACCTC	0.602000													20	99					0	0	0.008871	0	0
CDK18	5129	broad.mit.edu	37	1	205492349	205492349	+	Silent	SNP	C	C	T			TCGA-CS-6670-01A-11D-1893-08	TCGA-CS-6670-10A-01D-1893-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	44e94c3e-4910-440b-b21e-c0fcb9d9de16	b1a2bea4-c820-4301-ad17-0605363483bd	g.chr1:205492349C>T	ENST00000360066.2	+	2	355	c.54C>T	c.(52-54)ccC>ccT	p.P18P	CDK18_ENST00000506784.1_Silent_p.P18P|CDK18_ENST00000509056.1_Intron|CDK18_ENST00000429964.2_Silent_p.P18P	NM_002596.3|NM_212502.2|NM_212503.2	NP_002587.2|NP_997667.1|NP_997668.1	Q07002	CDK18_HUMAN	cyclin-dependent kinase 18	16							ATP binding|cyclin-dependent protein kinase activity|protein binding|signal transducer activity			breast(2)|endometrium(2)|large_intestine(2)|lung(10)|stomach(2)|urinary_tract(1)	19						TGTCAGTGCCCCGCACTGAGA	0.552000													40	62					0	0	0.007835	0	0
CTNNA3	29119	broad.mit.edu	37	10	69366623	69366623	+	Missense_Mutation	SNP	C	C	T			TCGA-CS-6670-01A-11D-1893-08	TCGA-CS-6670-10A-01D-1893-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	44e94c3e-4910-440b-b21e-c0fcb9d9de16	b1a2bea4-c820-4301-ad17-0605363483bd	g.chr10:69366623C>T	ENST00000433211.1	-	3	458	c.284G>A	c.(283-285)cGc>cAc	p.R95H	CTNNA3_ENST00000373744.4_Missense_Mutation_p.R95H|CTNNA3_ENST00000545309.1_Missense_Mutation_p.R95H	NM_013266.2	NP_037398.2	Q9UI47	CTNA3_HUMAN	catenin (cadherin-associated protein), alpha 3	95					cell-cell adhesion	actin cytoskeleton|cytoplasm|fascia adherens	cadherin binding|structural molecule activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(14)|liver(1)|lung(50)|ovary(2)|pancreas(2)|prostate(2)|skin(7)|stomach(1)|urinary_tract(1)	95						ACTTTCTTTGCGAACTTCCTC	0.423000													24	102					0	0	0.003330	0	0
DLGAP2	9228	broad.mit.edu	37	8	1626399	1626399	+	Missense_Mutation	SNP	T	T	A			TCGA-CS-6670-01A-11D-1893-08	TCGA-CS-6670-10A-01D-1893-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	44e94c3e-4910-440b-b21e-c0fcb9d9de16	b1a2bea4-c820-4301-ad17-0605363483bd	g.chr8:1626399T>A	ENST00000421627.2	+	9	2202	c.2068T>A	c.(2068-2070)Tct>Act	p.S690T		NM_004745.3	NP_004736.2	Q9P1A6	DLGP2_HUMAN	discs, large (Drosophila) homolog-associated protein 2	769					neuron-neuron synaptic transmission	cell junction|neurofilament|postsynaptic density|postsynaptic membrane	protein binding			breast(1)|endometrium(6)|lung(31)|prostate(3)	41		Ovarian(12;0.0271)|Hepatocellular(245;0.0838)|Colorectal(14;0.0846)		BRCA - Breast invasive adenocarcinoma(11;0.000169)|READ - Rectum adenocarcinoma(644;0.171)		TTTTAAACGTTCTAACAGCGT	0.552000													13	82					0	0	0.003163	0	0
AC024560.3	0	broad.mit.edu	37	3	197348646	197348646	+	RNA	SNP	T	T	C	rs138265355	by1000genomes	TCGA-CS-6670-01A-11D-1893-08	TCGA-CS-6670-10A-01D-1893-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	44e94c3e-4910-440b-b21e-c0fcb9d9de16	b1a2bea4-c820-4301-ad17-0605363483bd	g.chr3:197348646T>C	ENST00000418868.1	-	0	613					NR_003266.2																						TGGGCCTGCCTGCCCTTTCCA	0.532000													3	88					0	0	0.004672	0	0
PTPN13	0	broad.mit.edu	37	4	87643480	87643480	+	Silent	SNP	T	T	C			TCGA-CS-6670-01A-11D-1893-08	TCGA-CS-6670-10A-01D-1893-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	44e94c3e-4910-440b-b21e-c0fcb9d9de16	b1a2bea4-c820-4301-ad17-0605363483bd	g.chr4:87643480T>C	ENST00000436978.1	+	10	1981	c.1501T>C	c.(1501-1503)Ttg>Ctg	p.L501L	PTPN13_ENST00000511467.1_Silent_p.L501L|PTPN13_ENST00000411767.2_Silent_p.L501L|PTPN13_ENST00000427191.2_Silent_p.L501L|PTPN13_ENST00000316707.6_Silent_p.L501L	NM_080683.2|NM_080685.2	NP_542414.1|NP_542416.1	Q12923	PTN13_HUMAN	protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)	501						cytoplasm|cytoskeleton|plasma membrane	protein binding|protein tyrosine phosphatase activity			NS(4)|breast(3)|central_nervous_system(1)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(12)|large_intestine(23)|lung(24)|ovary(4)|prostate(3)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(2)	93		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.242)		OV - Ovarian serous cystadenocarcinoma(123;0.00082)		ACAGTCTCGGTTGAGCCTATA	0.443000													20	126					0	0	0.010504	0	0
ZNF799	90576	broad.mit.edu	37	19	12501372	12501372	+	Missense_Mutation	SNP	T	T	C			TCGA-CS-6670-01A-11D-1893-08	TCGA-CS-6670-10A-01D-1893-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	44e94c3e-4910-440b-b21e-c0fcb9d9de16	b1a2bea4-c820-4301-ad17-0605363483bd	g.chr19:12501372T>C	ENST00000419318.1	-	4	2493	c.1744A>G	c.(1744-1746)Act>Gct	p.T582A	CTD-3105H18.14_ENST00000435033.1_Intron|ZNF799_ENST00000430385.3_Missense_Mutation_p.T614A			Q96GE5	ZN799_HUMAN	zinc finger protein 799	614					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(3)|kidney(2)|large_intestine(4)|lung(4)|ovary(2)|prostate(2)|skin(2)	19						CCAGTGTGAGTTTTTTTCCAG	0.408000													4	184					0	0	0.009096	0	0
SHC4	399694	broad.mit.edu	37	15	49148220	49148220	+	Missense_Mutation	SNP	A	A	C			TCGA-CS-6670-01A-11D-1893-08	TCGA-CS-6670-10A-01D-1893-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	44e94c3e-4910-440b-b21e-c0fcb9d9de16	b1a2bea4-c820-4301-ad17-0605363483bd	g.chr15:49148220A>C	ENST00000332408.4	-	8	1600	c.1172T>G	c.(1171-1173)aTg>aGg	p.M391R	SHC4_ENST00000537958.1_Missense_Mutation_p.M105R|SHC4_ENST00000396535.3_Missense_Mutation_p.M148R	NM_203349.3	NP_976224.3	Q6S5L8	SHC4_HUMAN	SHC (Src homology 2 domain containing) family, member 4	391	CH1.				intracellular signal transduction	cell junction|postsynaptic membrane				breast(1)|endometrium(2)|large_intestine(8)|lung(11)|ovary(3)|pancreas(2)|skin(1)|upper_aerodigestive_tract(1)	29		all_lung(180;0.00466)		all cancers(107;9.4e-08)|GBM - Glioblastoma multiforme(94;5.94e-07)		TTTGATCCGCATATCTGAAAC	0.428000													19	138					0	0	0.007413	0	0
ULK4	54986	broad.mit.edu	37	3	41795900	41795900	+	Silent	SNP	A	A	G			TCGA-CS-6670-01A-11D-1893-08	TCGA-CS-6670-10A-01D-1893-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	44e94c3e-4910-440b-b21e-c0fcb9d9de16	b1a2bea4-c820-4301-ad17-0605363483bd	g.chr3:41795900A>G	ENST00000301831.4	-	22	2736	c.2274T>C	c.(2272-2274)taT>taC	p.Y758Y		NM_017886.2	NP_060356.2	Q96C45	ULK4_HUMAN	unc-51 like kinase 4	758							ATP binding|protein serine/threonine kinase activity			breast(2)|cervix(1)|large_intestine(6)|lung(7)|prostate(5)|skin(1)	22				KIRC - Kidney renal clear cell carcinoma(284;0.214)		AAATCAAAATATATAGAAGAA	0.383000													21	114					0	0	0.012319	0	0
SCN2B	6327	broad.mit.edu	37	11	118037639	118037639	+	Missense_Mutation	SNP	G	G	A	rs140034265		TCGA-CS-6670-01A-11D-1893-08	TCGA-CS-6670-10A-01D-1893-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	44e94c3e-4910-440b-b21e-c0fcb9d9de16	b1a2bea4-c820-4301-ad17-0605363483bd	g.chr11:118037639G>A	ENST00000278947.5	-	4	852	c.611C>T	c.(610-612)aCg>aTg	p.T204M		NM_004588.4	NP_004579.1	O60939	SCN2B_HUMAN	sodium channel, voltage-gated, type II, beta subunit	204					synaptic transmission	voltage-gated sodium channel complex	voltage-gated sodium channel activity			haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(2)	7	all_hematologic(175;0.046)	Medulloblastoma(222;0.0425)|Breast(348;0.181)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;3.19e-05)|Epithelial(105;0.00117)		TTCACCGTCCGTCTTGCCCTC	0.602000													52	70					0	0	0.014410	0	0
ZPBP	11055	broad.mit.edu	37	7	50023024	50023024	+	Missense_Mutation	SNP	C	C	T			TCGA-CS-6670-01A-11D-1893-08	TCGA-CS-6670-10A-01D-1893-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	44e94c3e-4910-440b-b21e-c0fcb9d9de16	b1a2bea4-c820-4301-ad17-0605363483bd	g.chr7:50023024C>T	ENST00000046087.2	-	7	944	c.875G>A	c.(874-876)gGt>gAt	p.G292D	ZPBP_ENST00000419417.1_Missense_Mutation_p.G291D|ZPBP_ENST00000491129.1_5'UTR	NM_001159878.1|NM_007009.2	NP_001153350.1|NP_008940.2	Q9BS86	ZPBP1_HUMAN	zona pellucida binding protein	292					binding of sperm to zona pellucida	extracellular region				NS(1)|breast(1)|endometrium(3)|kidney(1)|large_intestine(3)|lung(17)|prostate(3)	29	Glioma(55;0.08)|all_neural(89;0.245)					TTGGAGAGTACCTTCAATATA	0.353000													3	47					0	0	0.004672	0	0
TLE3	7090	broad.mit.edu	37	15	70366872	70366872	+	Splice_Site	SNP	C	C	T			TCGA-CS-6670-01A-11D-1893-08	TCGA-CS-6670-10A-01D-1893-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	44e94c3e-4910-440b-b21e-c0fcb9d9de16	b1a2bea4-c820-4301-ad17-0605363483bd	g.chr15:70366872C>T	ENST00000558939.1	-	6	1749	c.372_splice	c.e6+1	p.G124_splice	TLE3_ENST00000442299.2_Splice_Site_p.G124_splice|TLE3_ENST00000557997.1_Splice_Site_p.G124_splice|TLE3_ENST00000558379.1_Splice_Site_p.G124_splice|TLE3_ENST00000560939.1_Splice_Site_p.G130_splice|TLE3_ENST00000317509.8_Splice_Site_p.G124_splice|TLE3_ENST00000451782.2_Splice_Site_p.G124_splice|TLE3_ENST00000558201.1_Splice_Site_p.G130_splice|TLE3_ENST00000539550.1_Silent_p.G58G|TLE3_ENST00000557907.1_Splice_Site_p.G124_splice|TLE3_ENST00000559929.1_Silent_p.G124G|TLE3_ENST00000560589.1_Splice_Site_p.G68_splice|TLE3_ENST00000440567.3_Splice_Site_p.G117_splice|TLE3_ENST00000559048.1_Splice_Site_p.G130_splice|TLE3_ENST00000559191.1_Intron			Q04726	TLE3_HUMAN	transducin-like enhancer of split 3 (E(sp1) homolog, Drosophila)	124	Gln-rich.				organ morphogenesis|regulation of transcription, DNA-dependent|transcription, DNA-dependent|Wnt receptor signaling pathway	nucleus	protein binding			breast(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(16)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	31						GTCCACGTACCCCGATGATGG	0.557000													4	28					0	0	0.000602	0	0
UGT1A7	0	broad.mit.edu	37	2	234591431	234591431	+	Missense_Mutation	SNP	T	T	C			TCGA-CS-6670-01A-11D-1893-08	TCGA-CS-6670-10A-01D-1893-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	44e94c3e-4910-440b-b21e-c0fcb9d9de16	b1a2bea4-c820-4301-ad17-0605363483bd	g.chr2:234591431T>C	ENST00000373426.3	+	1	848	c.848T>C	c.(847-849)gTg>gCg	p.V283A	UGT1A10_ENST00000373445.1_Intron|UGT1A8_ENST00000373450.4_Intron|UGT1A9_ENST00000354728.4_Intron|UGT1A10_ENST00000344644.5_Intron	NM_019077.2	NP_061950.2														NS(1)|endometrium(6)|kidney(5)|large_intestine(5)|liver(1)|lung(12)|ovary(1)|prostate(1)|skin(1)	33		Breast(86;0.000765)|all_lung(227;0.00267)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0328)|Lung NSC(271;0.0457)|Lung SC(224;0.128)		Epithelial(121;8.93e-18)|BRCA - Breast invasive adenocarcinoma(100;0.000412)|Lung(119;0.00333)|LUSC - Lung squamous cell carcinoma(224;0.00746)		GGAAAGCCAGTGCCTATGGTA	0.368000													32	191					0	0	0.013726	0	0
DYNC2H1	79659	broad.mit.edu	37	11	103056994	103056994	+	Silent	SNP	T	T	C			TCGA-CS-6670-01A-11D-1893-08	TCGA-CS-6670-10A-01D-1893-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	44e94c3e-4910-440b-b21e-c0fcb9d9de16	b1a2bea4-c820-4301-ad17-0605363483bd	g.chr11:103056994T>C	ENST00000375735.2	+	42	6801	c.6657T>C	c.(6655-6657)tcT>tcC	p.S2219S	DYNC2H1_ENST00000334267.7_Intron|DYNC2H1_ENST00000398093.3_Silent_p.S2219S	NM_001080463.1|NM_001377.2	NP_001073932.1|NP_001368.2	Q8NCM8	DYHC2_HUMAN	dynein, cytoplasmic 2, heavy chain 1	2219					cell projection organization|Golgi organization|microtubule-based movement|multicellular organismal development	cilium axoneme|dynein complex|Golgi apparatus|microtubule|plasma membrane	ATP binding|ATPase activity|microtubule motor activity			NS(1)|endometrium(4)|kidney(5)|large_intestine(9)|lung(9)|ovary(1)|prostate(2)|upper_aerodigestive_tract(2)	33		Acute lymphoblastic leukemia(157;0.000966)|all_hematologic(158;0.00348)		BRCA - Breast invasive adenocarcinoma(274;0.000177)|Epithelial(105;0.0785)		CACGAGAATCTCCTCCAGACT	0.378000													8	34					0	0	0.006214	0	0
SLC4A2	6522	broad.mit.edu	37	7	150767364	150767364	+	Missense_Mutation	SNP	G	G	T			TCGA-CS-6670-01A-11D-1893-08	TCGA-CS-6670-10A-01D-1893-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	44e94c3e-4910-440b-b21e-c0fcb9d9de16	b1a2bea4-c820-4301-ad17-0605363483bd	g.chr7:150767364G>T	ENST00000485713.1	+	10	2420	c.1380G>T	c.(1378-1380)gaG>gaT	p.E460D	SLC4A2_ENST00000392826.2_Missense_Mutation_p.E451D|SLC4A2_ENST00000413384.2_Missense_Mutation_p.E460D|SLC4A2_ENST00000461735.1_Missense_Mutation_p.E446D|SLC4A2_ENST00000310317.5_Missense_Mutation_p.E378D	NM_001199692.1	NP_001186621.1	P04920	B3A2_HUMAN	solute carrier family 4 (anion exchanger), member 2	460				LLGHHHGQGAESDPHVTEPLMGGVPE -> CWGITMVRGLR VTPTSPSLSWEVFLR (in Ref. 6; CAA27556).	bicarbonate transport	integral to membrane|membrane fraction	inorganic anion exchanger activity			NS(1)|central_nervous_system(2)|endometrium(3)|kidney(1)|large_intestine(2)|liver(2)|lung(14)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	33			OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		AGGGGGCTGAGAGTGACCCCC	0.652000													10	83					9.70103e-10	1.3176e-09	0.008291	1	0
AC074391.1	0	broad.mit.edu	37	2	65738847	65738847	+	RNA	DEL	T	T	-	rs111377658		TCGA-CS-6670-01A-11D-1893-08	TCGA-CS-6670-10A-01D-1893-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	44e94c3e-4910-440b-b21e-c0fcb9d9de16	b1a2bea4-c820-4301-ad17-0605363483bd	g.chr2:65738847delT	ENST00000377977.3	+	0	862																											ttttTTGAAATTTTTTTTTTT	0.294													2	4	---	---	---	---					
PTPRZ1	5803	broad.mit.edu	37	7	121659248	121659249	+	Frame_Shift_Ins	INS	-	-	A			TCGA-CS-6670-01A-11D-1893-08	TCGA-CS-6670-10A-01D-1893-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	44e94c3e-4910-440b-b21e-c0fcb9d9de16	b1a2bea4-c820-4301-ad17-0605363483bd	g.chr7:121659248_121659249insA	ENST00000393386.2	+	13	5325_5326	c.4914_4915insA	c.(4912-4917)gttaccfs	p.T1639fs	PTPRZ1_ENST00000449182.1_Frame_Shift_Ins_p.T779fs	NM_001206838.1|NM_002851.2	NP_001193767.1|NP_002842.2	P23471	PTPRZ_HUMAN	protein tyrosine phosphatase, receptor-type, Z polypeptide 1	1639					central nervous system development	integral to plasma membrane	protein binding|protein tyrosine/threonine phosphatase activity|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(3)|central_nervous_system(4)|cervix(1)|endometrium(4)|kidney(12)|large_intestine(17)|liver(1)|lung(42)|ovary(4)|prostate(5)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(2)	106						AGAAGGCAGTTATACCCCTTGT	0.426													44	64	---	---	---	---					
RP11-798G7.5	0	broad.mit.edu	37	17	43591984	43591985	+	RNA	INS	-	-	G			TCGA-CS-6670-01A-11D-1893-08	TCGA-CS-6670-10A-01D-1893-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	44e94c3e-4910-440b-b21e-c0fcb9d9de16	b1a2bea4-c820-4301-ad17-0605363483bd	g.chr17:43591984_43591985insG	ENST00000253803.2	+	0	267				LRRC37A4P_ENST00000579913.1_RNA																							GTGGGTCATGCGGAGCGAGTTT	0.411													7	90	---	---	---	---					
RP5-1043L13.1	0	broad.mit.edu	37	20	58889651	58889662	+	RNA	DEL	CATTCTCCCATT	CATTCTCCCATT	-	rs117834183	by1000genomes	TCGA-CS-6670-01A-11D-1893-08	TCGA-CS-6670-10A-01D-1893-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	44e94c3e-4910-440b-b21e-c0fcb9d9de16	b1a2bea4-c820-4301-ad17-0605363483bd	g.chr20:58889651_58889662delCATTCTCCCATT	ENST00000432910.1	+	0	332					NR_046099.1																						tccatccatccattctcccattcatccatcct	0.538													4	4	---	---	---	---