Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_Position	End_Position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_File	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	chromosome_name	start	stop	reference	variant	type	gene_name	transcript_name	transcript_species	transcript_source	transcript_version	strand	transcript_status	trv_type	c_position	amino_acid_change	ucsc_cons	domain	all_domains	deletion_substructures	transcript_error	NormalRefReads_WU	NormalVarReads_WU	NormalVAF_WU	TumorRefReads_WU	TumorVarReads_WU	TumorVAF_WU	RNARefReads_WU	RNAVarReads_WU	RNAVAF_WU
NRAS	0	genome.wustl.edu	36	1	115060267	115060267	+	Missense_Mutation	SNP	C	C	T	rs121434596		TCGA-AB-2839-03B-01W-0728-08	TCGA-AB-2839-11B-01W-0729-08	C	C	C	T	C	C	Verified	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq	1	dbGAP	Illumina HiSeq	e46ca5db-40a6-4119-8f57-d5739cce62fe	2702acd2-a374-44e7-b9d5-c5caecdcbea0	1	115060267	115060267	C	T	SNP	NRAS	NM_002524.3	human	genbank	54_36p	-1	reviewed	missense	c.38	p.G13D	1.000	HMMSmart_SM00173,HMMSmart_SM00174,HMMSmart_SM00175,HMMPfam_Ras,superfamily_P-loop containing nucleoside triphosphate hydrolases	HMMSmart_SM00173,HMMSmart_SM00174,HMMSmart_SM00175,HMMPfam_Ras,superfamily_P-loop containing nucleoside triphosphate hydrolases	-	no_errors	92	2	2.13	58	35	37.63	37	13	26.00
DNMT3A	0	genome.wustl.edu	36	2	25321637	25321637	+	Nonsense_Mutation	SNP	G	G	A			TCGA-AB-2839-03B-01W-0728-08	TCGA-AB-2839-11B-01W-0729-08	G	G	G	A	G	G	Verified	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq	1	dbGAP	Illumina HiSeq	e46ca5db-40a6-4119-8f57-d5739cce62fe	2702acd2-a374-44e7-b9d5-c5caecdcbea0	2	25321637	25321637	G	A	SNP	DNMT3A	NM_022552.3	human	genbank	54_36p	-1	reviewed	nonsense	c.1543	p.Q515*	1.000	NULL	HMMPfam_PWWP,HMMSmart_SM00293,HMMPfam_DNA_methylase,superfamily_FYVE/PHD zinc finger,PatternScan_C5_MTASE_1,superfamily_S-adenosyl-L-methionine-dependent methyltransferases,superfamily_Tudor/PWWP/MBT	-	no_errors	18	0	0.00	12	15	55.56	27	16	37.21
CNTN6	0	genome.wustl.edu	36	3	1390299	1390299	+	Missense_Mutation	SNP	C	C	A			TCGA-AB-2839-03B-01W-0728-08	TCGA-AB-2839-11B-01W-0729-08	C	C	C	A	C	C	Verified	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq	1	dbGAP	Illumina HiSeq	e46ca5db-40a6-4119-8f57-d5739cce62fe	2702acd2-a374-44e7-b9d5-c5caecdcbea0	3	1390299	1390299	C	A	SNP	CNTN6	NM_014461.2	human	genbank	54_36p	+1	reviewed	missense	c.1798	p.P600T	1.000	HMMPfam_fn3,HMMSmart_FN3,superfamily_FN_III-like	HMMSmart_IGc2,HMMSmart_IG,HMMPfam_fn3,HMMSmart_FN3,superfamily_FN_III-like,HMMPfam_I-set,superfamily_SSF48726	-	no_errors	81	0	0.00	60	30	33.33	NA	NA	NA
VPRBP	0	genome.wustl.edu	36	3	51441853	51441853	+	Missense_Mutation	SNP	T	T	C			TCGA-AB-2839-03B-01W-0728-08	TCGA-AB-2839-11B-01W-0729-08	T	T	T	C	T	T	Verified	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq	1	dbGAP	Illumina HiSeq	e46ca5db-40a6-4119-8f57-d5739cce62fe	2702acd2-a374-44e7-b9d5-c5caecdcbea0	3	51441853	51441853	T	C	SNP	VPRBP	ENST00000273612	human	ensembl	54_36p	-1	known	missense	c.1589	p.K530R	1.000	superfamily_ARM repeat	HMMSmart_SM00667,superfamily_WD40 repeat-like,HMMPfam_LisH,superfamily_ARM repeat	-	no_errors	67	6	8.22	55	43	43.88	16	7	30.43
KDR	0	genome.wustl.edu	36	4	55675057	55675057	+	Missense_Mutation	SNP	G	G	A			TCGA-AB-2839-03B-01W-0728-08	TCGA-AB-2839-11B-01W-0729-08	G	G	G	A	G	G	Verified	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq	1	dbGAP	Illumina HiSeq	e46ca5db-40a6-4119-8f57-d5739cce62fe	2702acd2-a374-44e7-b9d5-c5caecdcbea0	4	55675057	55675057	G	A	SNP	KDR	NM_002253.2	human	genbank	54_36p	-1	validated	missense	c.791	p.S264F	0.630	HMMSmart_IG,HMMPfam_V-set,superfamily_SSF48726	HMMPfam_Pkinase_Tyr,HMMSmart_TyrKc,PatternScan_RECEPTOR_TYR_KIN_III,HMMSmart_IGc2,HMMSmart_IG,PatternScan_PROTEIN_KINASE_TYR,superfamily_Kinase_like,HMMPfam_I-set,HMMPfam_V-set,HMMPfam_ig,PatternScan_PROTEIN_KINASE_ATP,superfamily_SSF48726	-	no_errors	108	7	6.09	55	65	53.72	NA	NA	NA
TGFBI	0	genome.wustl.edu	36	5	135424452	135424452	+	Missense_Mutation	SNP	C	C	T			TCGA-AB-2839-03B-01W-0728-08	TCGA-AB-2839-11B-01W-0729-08	C	C	C	T	C	C	Verified	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq	1	dbGAP	Illumina HiSeq	e46ca5db-40a6-4119-8f57-d5739cce62fe	2702acd2-a374-44e7-b9d5-c5caecdcbea0	5	135424452	135424452	C	T	SNP	TGFBI	NM_000358.2	human	genbank	54_36p	+1	reviewed	missense	c.1834	p.P612S	0.998	HMMPfam_Fasciclin,HMMSmart_SM00554,superfamily_FAS1 domain	HMMPfam_Fasciclin,HMMSmart_SM00554,superfamily_FAS1 domain,HMMPfam_EMI	-	no_errors	213	3	1.39	49	27	35.53	0	1	100.00
SLC1A1	0	genome.wustl.edu	36	9	4566050	4566050	+	Missense_Mutation	SNP	G	G	A			TCGA-AB-2839-03B-01W-0728-08	TCGA-AB-2839-11B-01W-0729-08	G	G	G	A	G	G	Verified	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq	1	dbGAP	Illumina HiSeq	e46ca5db-40a6-4119-8f57-d5739cce62fe	2702acd2-a374-44e7-b9d5-c5caecdcbea0	9	4566050	4566050	G	A	SNP	SLC1A1	NM_004170.4	human	genbank	54_36p	+1	validated	missense	c.925	p.V309I	0.986	HMMPfam_SDF	HMMPfam_SDF,PatternScan_NA_DICARBOXYL_SYMP_1,PatternScan_NA_DICARBOXYL_SYMP_2	-	no_errors	141	8	5.37	71	75	51.37	NA	NA	NA
PRSS3	0	genome.wustl.edu	36	9	33785590	33785590	+	Missense_Mutation	SNP	C	C	T			TCGA-AB-2839-03B-01W-0728-08	TCGA-AB-2839-11B-01W-0729-08	C	C	C	T	C	C	Verified	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq	1	dbGAP	Illumina HiSeq	e46ca5db-40a6-4119-8f57-d5739cce62fe	2702acd2-a374-44e7-b9d5-c5caecdcbea0	9	33785590	33785590	C	T	SNP	PRSS3	NM_002771.3	human	genbank	54_36p	+1	reviewed	missense	c.19	p.L7F	0.941	NULL	HMMPfam_Trypsin,HMMSmart_SM00020,superfamily_Trypsin-like serine proteases,PatternScan_TRYPSIN_HIS	-	no_errors	105	8	7.08	48	37	43.53	NA	NA	NA
SMC3	0	genome.wustl.edu	36	10	112352977	112352977	+	Missense_Mutation	SNP	C	C	T			TCGA-AB-2839-03B-01W-0728-08	TCGA-AB-2839-11B-01W-0729-08	C	C	C	T	C	C	Verified	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq	1	dbGAP	Illumina HiSeq	e46ca5db-40a6-4119-8f57-d5739cce62fe	2702acd2-a374-44e7-b9d5-c5caecdcbea0	10	112352977	112352977	C	T	SNP	SMC3	NM_005445.3	human	genbank	54_36p	+1	reviewed	missense	c.3521	p.T1174I	1.000	HMMPfam_SMC_N,superfamily_P-loop containing nucleoside triphosphate hydrolases	HMMPfam_SMC_N,HMMPfam_SMC_hinge,superfamily_Smc hinge domain,PatternScan_ABC_TRANSPORTER_1,superfamily_P-loop containing nucleoside triphosphate hydrolases,superfamily_BAG domain	-	no_errors	23	4	14.81	50	41	44.57	25	18	41.86
OR5AS1	0	genome.wustl.edu	36	11	55554670	55554670	+	Missense_Mutation	SNP	C	C	A			TCGA-AB-2839-03B-01W-0728-08	TCGA-AB-2839-11B-01W-0729-08	C	C	C	A	C	C	Verified	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq	1	dbGAP	Illumina HiSeq	e46ca5db-40a6-4119-8f57-d5739cce62fe	2702acd2-a374-44e7-b9d5-c5caecdcbea0	11	55554670	55554670	C	A	SNP	OR5AS1	NM_001001921.1	human	genbank	54_36p	+1	provisional	missense	c.200	p.S67Y	0.965	HMMPfam_7tm_1,superfamily_SSF81321	HMMPfam_7tm_1,PatternScan_G_PROTEIN_RECEP_F1_1,superfamily_SSF81321	-	no_errors	67	7	9.46	83	56	40.29	NA	NA	NA
CACNA2D4	0	genome.wustl.edu	36	12	1833394	1833394	+	Missense_Mutation	SNP	C	C	A			TCGA-AB-2839-03B-01W-0728-08	TCGA-AB-2839-11B-01W-0729-08	C	C	C	A	C	C	Verified	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq	1	dbGAP	Illumina HiSeq	e46ca5db-40a6-4119-8f57-d5739cce62fe	2702acd2-a374-44e7-b9d5-c5caecdcbea0	12	1833394	1833394	C	A	SNP	CACNA2D4	NM_172364.4	human	genbank	54_36p	-1	reviewed	missense	c.2230	p.A744S	0.824	NULL	HMMPfam_VWA,HMMSmart_SM00327,HMMPfam_Cache_1,HMMPfam_VWA_N,superfamily_vWA-like	-	no_errors	89	6	6.32	25	35	58.33	6	11	64.71
SLC39A5	0	genome.wustl.edu	36	12	54917304	54917304	+	Silent	SNP	G	G	T			TCGA-AB-2839-03B-01W-0728-08	TCGA-AB-2839-11B-01W-0729-08	G	G	G	T	G	G	Verified	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq	1	dbGAP	Illumina HiSeq	e46ca5db-40a6-4119-8f57-d5739cce62fe	2702acd2-a374-44e7-b9d5-c5caecdcbea0	12	54917304	54917304	G	T	SNP	SLC39A5	NM_173596.1	human	genbank	54_36p	+1	validated	silent	c.1389	p.V463	0.997	HMMPfam_Zip	HMMPfam_Zip	-	no_errors	37	1	2.63	14	12	46.15	2	0	0.00
PTPN11	0	genome.wustl.edu	36	12	111424364	111424364	+	Missense_Mutation	SNP	A	A	C			TCGA-AB-2839-03B-01W-0728-08	TCGA-AB-2839-11B-01W-0729-08	A	A	A	C	A	A	Verified	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq	1	dbGAP	Illumina HiSeq	e46ca5db-40a6-4119-8f57-d5739cce62fe	2702acd2-a374-44e7-b9d5-c5caecdcbea0	12	111424364	111424364	A	C	SNP	PTPN11	NM_002834.3	human	genbank	54_36p	+1	reviewed	missense	c.1633	p.I545L	1.000	NULL	HMMPfam_Y_phosphatase,HMMSmart_SM00194,HMMPfam_SH2,HMMSmart_SM00252,HMMSmart_SM00404,PatternScan_TYR_PHOSPHATASE_1,superfamily_(Phosphotyrosine protein) phosphatases II,superfamily_SH2 domain	-	no_errors	65	3	4.41	35	36	50.70	23	22	48.89
C15orf57	0	genome.wustl.edu	36	15	38642377	38642377	+	Missense_Mutation	SNP	C	C	T			TCGA-AB-2839-03B-01W-0728-08	TCGA-AB-2839-11B-01W-0729-08	C	C	C	T	C	C	Verified	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq	1	dbGAP	Illumina HiSeq	e46ca5db-40a6-4119-8f57-d5739cce62fe	2702acd2-a374-44e7-b9d5-c5caecdcbea0	15	38642377	38642377	C	T	SNP	C15orf57	NM_001080791.1	human	genbank	54_36p	-1	validated	missense	c.157	p.V53M	0.251	NULL	NULL	-	no_errors	119	3	2.46	33	27	45.00	26	20	43.48
DUOXA2	0	genome.wustl.edu	36	15	43195656	43195656	+	Missense_Mutation	SNP	C	C	A			TCGA-AB-2839-03B-01W-0728-08	TCGA-AB-2839-11B-01W-0729-08	C	C	C	A	C	C	Verified	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq	1	dbGAP	Illumina HiSeq	e46ca5db-40a6-4119-8f57-d5739cce62fe	2702acd2-a374-44e7-b9d5-c5caecdcbea0	15	43195656	43195656	C	A	SNP	DUOXA2	NM_207581.2	human	genbank	54_36p	+1	validated	missense	c.248	p.T83N	0.999	HMMPfam_DuoxA	HMMPfam_DuoxA	-	no_errors	29	1	3.33	15	12	44.44	NA	NA	NA
TM6SF1	0	genome.wustl.edu	36	15	81575626	81575626	+	Silent	SNP	C	C	T			TCGA-AB-2839-03B-01W-0728-08	TCGA-AB-2839-11B-01W-0729-08	C	C	C	T	C	C	Verified	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq	1	dbGAP	Illumina HiSeq	e46ca5db-40a6-4119-8f57-d5739cce62fe	2702acd2-a374-44e7-b9d5-c5caecdcbea0	15	81575626	81575626	C	T	SNP	TM6SF1	NM_023003.1	human	genbank	54_36p	+1	validated	silent	c.222	p.S74	0.954	NULL	NULL	-	no_errors	222	11	4.72	56	37	39.78	NA	NA	NA
RALGAPA2	0	genome.wustl.edu	36	20	20558211	20558211	+	Missense_Mutation	SNP	C	C	A			TCGA-AB-2839-03B-01W-0728-08	TCGA-AB-2839-11B-01W-0729-08	C	C	C	A	C	C	Verified	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq	1	dbGAP	Illumina HiSeq	e46ca5db-40a6-4119-8f57-d5739cce62fe	2702acd2-a374-44e7-b9d5-c5caecdcbea0	20	20558211	20558211	C	A	SNP	C20orf74	NM_020343.2	human	genbank	54_36p	-1	validated	missense	c.1029	p.Q343H	0.972	NULL	HMMPfam_Rap_GAP,superfamily_Rap/Ran-GAP (Pfam 02145)	-	no_errors	78	5	6.02	74	56	43.08	9	14	60.87
IGSF5	0	genome.wustl.edu	36	21	40064940	40064940	+	Missense_Mutation	SNP	G	G	A			TCGA-AB-2839-03B-01W-0728-08	TCGA-AB-2839-11B-01W-0729-08	G	G	G	A	G	G	Verified	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq	1	dbGAP	Illumina HiSeq	e46ca5db-40a6-4119-8f57-d5739cce62fe	2702acd2-a374-44e7-b9d5-c5caecdcbea0	21	40064940	40064940	G	A	SNP	IGSF5	NM_001080444.1	human	genbank	54_36p	+1	provisional	missense	c.646	p.V216M	0.992	HMMSmart_IG,superfamily_SSF48726	HMMSmart_IG,HMMPfam_I-set,superfamily_SSF48726	-	no_errors	36	2	5.26	42	33	44.00	NA	NA	NA
NPM1	0	genome.wustl.edu	36	5	170770148	170770149	+	Frame_Shift_Ins	INS	-	-	TATG			TCGA-AB-2839-03B-01W-0728-08	TCGA-AB-2839-11B-01W-0729-08	-	-	-	TATG	-	-	Verified	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq	1	dbGAP	Illumina HiSeq	e46ca5db-40a6-4119-8f57-d5739cce62fe	2702acd2-a374-44e7-b9d5-c5caecdcbea0	5	170770148	170770149	-	TATG	INS	NPM1	NM_002520.1	human	genbank	54_36p	+1	validated	frame_shift_ins	c.859_860	p.W288fs	1.000:1.000	NULL	HMMPfam_Nucleoplasmin,superfamily_Nucleoplasmin-like core domain	-	no_errors	NA	NA	NA	NA	NA	NA	NA	NA	NA
WT1	0	genome.wustl.edu	36	11	32374484	32374485	+	Frame_Shift_Ins	INS	-	-	CCGA			TCGA-AB-2839-03B-01W-0728-08	TCGA-AB-2839-11B-01W-0729-08	-	-	-	CCGA	-	-	Verified	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq	1	dbGAP	Illumina HiSeq	e46ca5db-40a6-4119-8f57-d5739cce62fe	2702acd2-a374-44e7-b9d5-c5caecdcbea0	11	32374484	32374485	-	CCGA	INS	WT1	NM_024426.3	human	genbank	54_36p	-1	reviewed	frame_shift_ins	c.1144_1143	p.A381fs	0.833:0.771	HMMPfam_WT1	HMMPfam_WT1,HMMPfam_zf-C2H2,PatternScan_ZINC_FINGER_C2H2_1,HMMSmart_SM00355,superfamily_C2H2 and C2HC zinc fingers	-	no_errors	NA	NA	NA	NA	NA	NA	NA	NA	NA
CEBPA	0	genome.wustl.edu	36	19	38484134	38484134	+	Frame_Shift_Del	DEL	G	G	-			TCGA-AB-2839-03B-01W-0728-08	TCGA-AB-2839-11B-01W-0729-08	G	G	G	-	G	G	Verified	Valid	Somatic	Phase_IV	WXS	Hybrid_Capture_Illumina_Seq	1	dbGAP	Illumina HiSeq	e46ca5db-40a6-4119-8f57-d5739cce62fe	2702acd2-a374-44e7-b9d5-c5caecdcbea0	19	38484134	38484134	G	-	DEL	CEBPA	NM_004364.3	human	genbank	54_36p	-1	reviewed	frame_shift_del	c.1027	p.R343fs	1.000	HMMSmart_BRLZ	HMMSmart_BRLZ,PatternScan_BZIP_BASIC,HMMPfam_bZIP_2	-	no_errors	1	0	0.00	9	4	30.77	66	47	41.59