Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
TAF3	83860	broad.mit.edu	37	10	8006092	8006092	+	Missense_Mutation	SNP	G	G	T			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr10:8006092G>T	ENST00000344293.5	+	3	825	c.619G>T	c.(619-621)Gtt>Ttt	p.V207F		NM_031923.3	NP_114129.1	Q5VWG9	TAF3_HUMAN	TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 140kDa	207					maintenance of protein location in nucleus|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	transcription factor TFIID complex	protein binding|zinc ion binding			NS(2)|breast(4)|endometrium(2)|kidney(1)|large_intestine(6)|lung(16)|ovary(3)|prostate(4)|skin(2)	40						CACGCTAGATGTTGTGTTATT	0.488000													18	162					8.04996e-18	8.98782e-18	1	1	0
CT47B1	643311	broad.mit.edu	37	X	120007830	120007830	+	Missense_Mutation	SNP	C	C	T			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chrX:120007830C>T	ENST00000371311.3	-	2	1074	c.820G>A	c.(820-822)Gat>Aat	p.D274N		NM_001145718.1	NP_001139190.1	P0C2W7	CT47B_HUMAN	cancer/testis antigen family 47, member B1	274										breast(1)|central_nervous_system(1)|endometrium(7)|kidney(2)|lung(9)|ovary(1)|skin(1)	22						CCTGCAGCATCTTGGGCCTCT	0.463000													25	556					0	0	1	0	0
GLS2	27165	broad.mit.edu	37	12	56871719	56871719	+	Missense_Mutation	SNP	T	T	G			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr12:56871719T>G	ENST00000311966.4	-	6	1054	c.776A>C	c.(775-777)gAa>gCa	p.E259A		NM_013267.2	NP_037399.2	Q9UI32	GLSL_HUMAN	glutaminase 2 (liver, mitochondrial)	259					cellular amino acid biosynthetic process|glutamate secretion|glutamine metabolic process|neurotransmitter secretion	mitochondrial matrix	glutaminase activity|protein binding			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(4)|ovary(1)|stomach(1)|urinary_tract(1)	13					L-Glutamic Acid(DB00142)|L-Glutamine(DB00130)	GTGCTCACCTTCCTCATTGAG	0.527000													13	365					0	0	1	0	0
ANK1	286	broad.mit.edu	37	8	41559142	41559142	+	Splice_Site	SNP	T	T	A			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr8:41559142T>A	ENST00000396942.1	-	22	2472		c.e22-2		ANK1_ENST00000379758.2_Splice_Site|ANK1_ENST00000265709.8_Splice_Site|ANK1_ENST00000289734.7_Splice_Site|ANK1_ENST00000352337.4_Splice_Site|ANK1_ENST00000396945.1_Splice_Site|ANK1_ENST00000347528.4_Splice_Site			P16157	ANK1_HUMAN	ankyrin 1, erythrocytic						axon guidance|cytoskeleton organization|exocytosis|maintenance of epithelial cell apical/basal polarity|signal transduction	basolateral plasma membrane|cytosol|sarcomere|sarcoplasmic reticulum|spectrin-associated cytoskeleton	cytoskeletal adaptor activity|enzyme binding|protein binding|spectrin binding|structural constituent of cytoskeleton			breast(5)|central_nervous_system(4)|endometrium(9)|kidney(1)|large_intestine(26)|lung(62)|ovary(3)|prostate(5)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	122	Ovarian(28;0.00541)|Colorectal(14;0.0398)|Lung SC(25;0.211)	all_lung(54;0.000626)|Lung NSC(58;0.00245)|Esophageal squamous(32;0.0559)|Hepatocellular(245;0.0663)|Renal(179;0.188)	OV - Ovarian serous cystadenocarcinoma(14;0.000984)|Lung(22;0.00108)|Colorectal(10;0.00245)|LUSC - Lung squamous cell carcinoma(45;0.00392)|COAD - Colon adenocarcinoma(11;0.0264)			ACTGACTAACTAAAACGAGAA	0.468000											OREG0018740	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	5	92					0	0	1	0	0
DYNC1H1	1778	broad.mit.edu	37	14	102445654	102445654	+	Splice_Site	SNP	A	A	T			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr14:102445654A>T	ENST00000360184.4	+	3	508		c.e3-1			NM_001376.4	NP_001367.2	Q14204	DYHC1_HUMAN	dynein, cytoplasmic 1, heavy chain 1						cytoplasmic mRNA processing body assembly|G2/M transition of mitotic cell cycle|microtubule-based movement|mitotic spindle organization|stress granule assembly|transport	centrosome|cytoplasmic dynein complex|cytosol|Golgi apparatus|microtubule	ATP binding|ATPase activity, coupled|microtubule motor activity|protein binding			NS(1)|biliary_tract(1)|breast(4)|central_nervous_system(5)|cervix(1)|endometrium(21)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(28)|lung(60)|ovary(9)|pancreas(1)|prostate(6)|skin(7)|stomach(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	166						TTTTCTTTTTAGCTTGGCATT	0.358000													6	141					0	0	1	0	0
ITPR2	3709	broad.mit.edu	37	12	26848562	26848562	+	Missense_Mutation	SNP	C	C	T			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr12:26848562C>T	ENST00000381340.3	-	10	1389	c.973G>A	c.(973-975)Gcc>Acc	p.A325T		NM_002223.2	NP_002214.2	Q14571	ITPR2_HUMAN	inositol 1,4,5-trisphosphate receptor, type 2	325	MIR 4.				activation of phospholipase C activity|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	integral to membrane|plasma membrane enriched fraction|platelet dense tubular network membrane|sarcoplasmic reticulum membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity		ETV6/ITPR2(2)	biliary_tract(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(16)|large_intestine(20)|liver(1)|lung(51)|ovary(5)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(5)|urinary_tract(3)	125	Colorectal(261;0.0847)					TCATTTTGGGCATCTCGATAA	0.299000													18	84					0	0	1	0	0
ARPC2	10109	broad.mit.edu	37	2	219099073	219099073	+	Splice_Site	SNP	A	A	T			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr2:219099073A>T	ENST00000295685.10	+	4	483		c.e4-1		ARPC2_ENST00000315717.5_Splice_Site	NM_005731.2	NP_005722.1	O15144	ARPC2_HUMAN	actin related protein 2/3 complex, subunit 2, 34kDa						cellular component movement	Arp2/3 protein complex|cell projection|Golgi apparatus	actin binding|structural constituent of cytoskeleton			cervix(1)|kidney(1)|large_intestine(2)|lung(1)|ovary(1)	6		Renal(207;0.0474)		Epithelial(149;1.21e-06)|all cancers(144;0.000212)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.0103)		TTTATTTTCTAGTTATTAAAG	0.363000													8	210					0	0	1	0	0
MYH2	4620	broad.mit.edu	37	17	10442759	10442759	+	Splice_Site	SNP	A	A	G			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr17:10442759A>G	ENST00000245503.5	-	13	1651		c.e13+1		MYH2_ENST00000532183.1_Splice_Site|CTC-297N7.7_ENST00000587182.1_RNA|MYH2_ENST00000397183.2_Splice_Site	NM_017534.5	NP_060004.3	Q9UKX2	MYH2_HUMAN	myosin, heavy chain 2, skeletal muscle, adult						muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(16)|lung(99)|ovary(6)|pancreas(4)|prostate(3)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(4)	176						TTATGCACCTACCTGTTCTAC	0.443000													91	235					0	0	1	0	0
CHEK2	11200	broad.mit.edu	37	22	29091841	29091841	+	Silent	SNP	G	G	A	rs146546850	byFrequency	TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr22:29091841G>A	ENST00000544772.1	-	12	1889	c.453C>T	c.(451-453)tcC>tcT	p.S151S	CHEK2_ENST00000382565.1_Intron|CHEK2_ENST00000348295.3_Silent_p.S343S|CHEK2_ENST00000405598.1_Silent_p.S372S|CHEK2_ENST00000328354.6_Silent_p.S372S|CHEK2_ENST00000403642.1_Silent_p.S281S|CHEK2_ENST00000382578.1_Silent_p.S281S|CHEK2_ENST00000382566.1_3'UTR|CHEK2_ENST00000382580.2_Silent_p.S415S|CHEK2_ENST00000404276.1_Silent_p.S372S|CHEK2_ENST00000402731.1_Silent_p.S343S	NM_001257387.1	NP_001244316.1	O96017	CHK2_HUMAN	checkpoint kinase 2	372	FHA.				cell cycle|DNA damage checkpoint|DNA damage response, signal transduction resulting in induction of apoptosis|replicative senescence	PML body	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity	p.S372S(8)		central_nervous_system(17)|endometrium(2)|kidney(11)|large_intestine(2)|lung(11)|ovary(1)|prostate(4)|stomach(2)	50						CCAAAATCTTGGAGTGCCCAA	0.413000			F			breast		Direct reversal of damage;Other conserved DNA damage response genes					6	160					0	0	1	0	0
RBBP6	5930	broad.mit.edu	37	16	24564874	24564874	+	Missense_Mutation	SNP	C	C	A			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr16:24564874C>A	ENST00000319715.4	+	4	776	c.344C>A	c.(343-345)aCa>aAa	p.T115K	RBBP6_ENST00000348022.2_Missense_Mutation_p.T115K|RBBP6_ENST00000381039.3_Missense_Mutation_p.T115K	NM_006910.4	NP_008841.2	Q7Z6E9	RBBP6_HUMAN	retinoblastoma binding protein 6	115					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	chromosome|nucleolus|ubiquitin ligase complex	nucleic acid binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(10)|lung(17)|ovary(4)|pancreas(1)|prostate(2)|urinary_tract(1)	46				GBM - Glioblastoma multiforme(48;0.0518)		GCCCAGCTTACAAAGGTATAT	0.323000													10	53					0.000978159	0.00101341	1	1	0
LAMA1	284217	broad.mit.edu	37	18	7046368	7046368	+	Splice_Site	SNP	T	T	A			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr18:7046368T>A	ENST00000389658.3	-	6	862		c.e6-2			NM_005559.3	NP_005550.2	P25391	LAMA1_HUMAN	laminin, alpha 1						axon guidance|cell adhesion|cell surface receptor linked signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	extracellular space|laminin-1 complex|laminin-3 complex	extracellular matrix structural constituent|receptor binding			NS(4)|breast(7)|central_nervous_system(3)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(49)|liver(1)|lung(71)|ovary(9)|pancreas(3)|prostate(5)|skin(11)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(3)	205		Colorectal(10;0.172)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	ATAATAATACTAAGGAAAAAG	0.338000													5	89					0	0	1	0	0
GRHL1	29841	broad.mit.edu	37	2	10101473	10101473	+	Missense_Mutation	SNP	G	G	C			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr2:10101473G>C	ENST00000324907.9	+	4	713	c.577G>C	c.(577-579)Gac>Cac	p.D193H	GRHL1_ENST00000405379.2_Missense_Mutation_p.D193H|GRHL1_ENST00000324883.5_Silent_p.L29L	NM_198182.2	NP_937825.2	Q9NZI5	GRHL1_HUMAN	grainyhead-like 1 (Drosophila)	193					cellular lipid metabolic process|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	Golgi apparatus|nucleus	DNA binding			cervix(1)|endometrium(1)|large_intestine(2)|lung(8)|ovary(1)|pancreas(1)|skin(1)|stomach(1)|urinary_tract(1)	17	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.172)|OV - Ovarian serous cystadenocarcinoma(76;0.246)		TCTCAATACTGACCAGTTCAG	0.542000													51	146					0	0	1	0	0
SPAG5	10615	broad.mit.edu	37	17	26919344	26919344	+	Silent	SNP	T	T	C	rs113667723	byFrequency	TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr17:26919344T>C	ENST00000321765.5	-	3	1250	c.918A>G	c.(916-918)acA>acG	p.T306T		NM_006461.3	NP_006452.3	Q96R06	SPAG5_HUMAN	sperm associated antigen 5	306					cell division|mitosis|phosphatidylinositol-mediated signaling|spindle organization	condensed chromosome kinetochore|cytoplasm|spindle pole	protein binding			NS(1)|breast(3)|central_nervous_system(1)|endometrium(5)|kidney(4)|large_intestine(8)|lung(17)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	43	Lung NSC(42;0.00431)					GTGTCAGGCATGTGGACAGAA	0.453000													8	215					0	0	1	0	0
PITX2	5308	broad.mit.edu	37	4	111539589	111539589	+	Missense_Mutation	SNP	A	A	T			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr4:111539589A>T	ENST00000354925.2	-	7	2351	c.646T>A	c.(646-648)Tct>Act	p.S216T	PITX2_ENST00000394595.3_Missense_Mutation_p.L147H|PITX2_ENST00000394598.2_Missense_Mutation_p.S216T|PITX2_ENST00000355080.5_Missense_Mutation_p.S170T|PITX2_ENST00000306732.3_Missense_Mutation_p.S223T	NM_001204397.1	NP_001191326.1	Q99697	PITX2_HUMAN	paired-like homeodomain 2	216					determination of left/right symmetry|organ morphogenesis	transcription factor complex	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding			breast(1)|endometrium(3)|large_intestine(1)|lung(5)	10		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.00222)		GACGAGATAGAGTTGGGTGGG	0.547000													55	138					0	0	1	0	0
PRKCI	5584	broad.mit.edu	37	3	170013697	170013697	+	Splice_Site	SNP	A	A	T			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr3:170013697A>T	ENST00000295797.4	+	15	1722		c.e15-1			NM_002740.5	NP_002731.4	P41743	KPCI_HUMAN	protein kinase C, iota						anti-apoptosis|cellular membrane organization|cellular response to insulin stimulus|establishment or maintenance of epithelial cell apical/basal polarity|intracellular signal transduction|nerve growth factor receptor signaling pathway|positive regulation of establishment of protein localization in plasma membrane|positive regulation of glucose import|protein targeting to membrane|secretion|tight junction assembly|vesicle-mediated transport	cytosol|endosome|nucleus|polarisome	ATP binding|phospholipid binding|protein binding|protein kinase C activity|zinc ion binding			breast(2)|endometrium(5)|kidney(1)|large_intestine(4)|lung(16)|ovary(2)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	36	all_cancers(22;6.45e-23)|all_epithelial(15;8.52e-28)|all_lung(20;6.31e-17)|Lung NSC(18;2.61e-16)|Ovarian(172;0.000337)|Breast(254;0.169)		Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.197)			TTATCTTTCTAGTTATTTTGG	0.308000													4	59					0	0	1	0	0
PCF11	51585	broad.mit.edu	37	11	82877725	82877725	+	Missense_Mutation	SNP	A	A	G			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr11:82877725A>G	ENST00000298281.4	+	5	2238	c.1786A>G	c.(1786-1788)Aga>Gga	p.R596G		NM_015885.3	NP_056969.2	O94913	PCF11_HUMAN	PCF11 cleavage and polyadenylation factor subunit	596					mRNA 3'-end processing|mRNA cleavage|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	mRNA cleavage factor complex		p.R695R(1)|p.R596R(1)		cervix(1)|endometrium(3)|kidney(4)|large_intestine(1)|lung(22)|ovary(1)|urinary_tract(1)	33						GTCTGCCAAAAGATGGAAATC	0.348000													47	141					0	0	1	0	0
CHEK2	11200	broad.mit.edu	37	22	29091840	29091840	+	Missense_Mutation	SNP	T	T	C	rs142470496	byFrequency	TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr22:29091840T>C	ENST00000544772.1	-	12	1890	c.454A>G	c.(454-456)Aag>Gag	p.K152E	CHEK2_ENST00000382565.1_Intron|CHEK2_ENST00000348295.3_Missense_Mutation_p.K344E|CHEK2_ENST00000405598.1_Missense_Mutation_p.K373E|CHEK2_ENST00000328354.6_Missense_Mutation_p.K373E|CHEK2_ENST00000403642.1_Missense_Mutation_p.K282E|CHEK2_ENST00000382578.1_Missense_Mutation_p.K282E|CHEK2_ENST00000382566.1_3'UTR|CHEK2_ENST00000382580.2_Missense_Mutation_p.K416E|CHEK2_ENST00000404276.1_Missense_Mutation_p.K373E|CHEK2_ENST00000402731.1_Missense_Mutation_p.K344E	NM_001257387.1	NP_001244316.1	O96017	CHK2_HUMAN	checkpoint kinase 2	373	FHA.				cell cycle|DNA damage checkpoint|DNA damage response, signal transduction resulting in induction of apoptosis|replicative senescence	PML body	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity	p.K373E(9)		central_nervous_system(17)|endometrium(2)|kidney(11)|large_intestine(2)|lung(11)|ovary(1)|prostate(4)|stomach(2)	50						CCCAAAATCTTGGAGTGCCCA	0.418000			F			breast		Direct reversal of damage;Other conserved DNA damage response genes					6	161					0	0	1	0	0
DOCK4	9732	broad.mit.edu	37	7	111555908	111555908	+	Missense_Mutation	SNP	C	C	T			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr7:111555908C>T	ENST00000428084.1	-	13	1390	c.1118G>A	c.(1117-1119)aGg>aAg	p.R373K	DOCK4_ENST00000437633.1_Missense_Mutation_p.R373K|DOCK4_ENST00000476846.1_5'UTR			Q8N1I0	DOCK4_HUMAN	dedicator of cytokinesis 4	373					cell chemotaxis	cytosol|endomembrane system|membrane|stereocilium	GTP binding|guanyl-nucleotide exchange factor activity|PDZ domain binding|Rac GTPase activator activity|Rac GTPase binding|receptor tyrosine kinase binding|SH3 domain binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(4)|kidney(4)|large_intestine(13)|lung(31)|ovary(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(4)	72		Acute lymphoblastic leukemia(1;0.0441)				TGAATATTCCCTTCTGATTTG	0.368000													7	31					0	0	1	0	0
C14orf37	145407	broad.mit.edu	37	14	58604706	58604706	+	Splice_Site	SNP	A	A	T			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr14:58604706A>T	ENST00000267485.7	-	2	1564		c.e2+1		C14orf37_ENST00000334342.5_Splice_Site	NM_001001872.2	NP_001001872.2	Q86TY3	CN037_HUMAN	chromosome 14 open reading frame 37							integral to membrane	binding			breast(7)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(16)|pancreas(1)|skin(1)	33						TCTTTCTTTTACCTTTCATTG	0.323000													6	116					0	0	1	0	0
PAK1IP1	55003	broad.mit.edu	37	6	10709469	10709469	+	Splice_Site	SNP	A	A	T			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr6:10709469A>T	ENST00000379568.3	+	10	1255		c.e10-1			NM_017906.2	NP_060376.2	Q9NWT1	PK1IP_HUMAN	PAK1 interacting protein 1						negative regulation of signal transduction	nucleolus|plasma membrane				kidney(1)|large_intestine(1)|lung(7)|prostate(2)|upper_aerodigestive_tract(1)	12	Ovarian(93;0.107)|Breast(50;0.137)	all_hematologic(90;0.117)				TTTGTGTTTTAGTAAGTAAAG	0.368000													7	79					0	0	1	0	0
CORO7	79585	broad.mit.edu	37	16	4412076	4412076	+	Silent	SNP	G	G	T			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr16:4412076G>T	ENST00000251166.4	-	16	1633	c.1488C>A	c.(1486-1488)acC>acA	p.T496T	CORO7_ENST00000574025.1_Silent_p.T411T|CORO7_ENST00000423908.2_Silent_p.T328T|CORO7-PAM16_ENST00000572467.1_Silent_p.T496T|CORO7_ENST00000539968.1_Silent_p.T276T|CORO7_ENST00000537233.2_Silent_p.T478T	NM_024535.4	NP_078811.3			coronin 7											breast(3)|central_nervous_system(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(1)|lung(8)|prostate(2)|skin(2)|urinary_tract(2)	23						CACCAGGTGTGGTGAGGTTGA	0.647000													2	3					0.0784	0.0790877	1	1	0
BUB1B	701	broad.mit.edu	37	15	40505655	40505655	+	Silent	SNP	G	G	A	rs146821149		TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr15:40505655G>A	ENST00000287598.6	+	20	2853	c.2658G>A	c.(2656-2658)agG>agA	p.R886R	BUB1B_ENST00000412359.3_Silent_p.R900R	NM_001211.5	NP_001202.4	O60566	BUB1B_HUMAN	BUB1 mitotic checkpoint serine/threonine kinase B	886	Protein kinase.				anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|cell division|cell proliferation|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|phosphatidylinositol-mediated signaling|protein localization to kinetochore|spindle organization	anaphase-promoting complex|condensed chromosome outer kinetochore|cytosol|microtubule organizing center|perinuclear region of cytoplasm|spindle midzone	ATP binding|protein binding|protein serine/threonine kinase activity			breast(2)|endometrium(1)|kidney(2)|large_intestine(7)|liver(2)|lung(17)|ovary(1)|stomach(2)|urinary_tract(2)	36		all_cancers(109;1.12e-18)|all_epithelial(112;1.61e-15)|Lung NSC(122;5.63e-11)|all_lung(180;1.4e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;1.83e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0556)		TGAGTCCAAGGTGTCTGATTC	0.348000			"""Mis, N, F, S"""			rhabdomyosarcoma			Mosaic Variegated Aneuploidy Syndrome				42	79					0	0	1	0	0
NEURL3	93082	broad.mit.edu	37	2	97164150	97164150	+	RNA	SNP	T	T	C			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr2:97164150T>C	ENST00000310865.3	-	0	942									neuralized E3 ubiquitin protein ligase 3																		GGCAGCGTGATAGAAGCAGAT	0.607000													36	63					0	0	1	0	0
EPB41	2035	broad.mit.edu	37	1	29319924	29319924	+	Missense_Mutation	SNP	T	T	A			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr1:29319924T>A	ENST00000343067.4	+	3	678	c.551T>A	c.(550-552)gTa>gAa	p.V184E	EPB41_ENST00000398863.2_Missense_Mutation_p.V184E|EPB41_ENST00000373797.1_Missense_Mutation_p.V184E|EPB41_ENST00000373798.1_Missense_Mutation_p.V184E|EPB41_ENST00000373800.3_5'UTR|EPB41_ENST00000356093.2_Missense_Mutation_p.V184E|EPB41_ENST00000349460.4_5'UTR|EPB41_ENST00000347529.3_Missense_Mutation_p.V184E	NM_001166005.1	NP_001159477.1	P11171	41_HUMAN	erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked)	184					blood circulation|cortical actin cytoskeleton organization|positive regulation of protein binding	extrinsic to membrane|Golgi apparatus|nucleus|plasma membrane|protein complex|spectrin|spectrin-associated cytoskeleton	1-phosphatidylinositol binding|actin binding|spectrin binding|structural constituent of cytoskeleton			NS(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(3)|ovary(2)|urinary_tract(1)	14		Colorectal(325;3.46e-05)|Prostate(1639;0.000244)|Lung NSC(340;0.00328)|all_lung(284;0.00412)|Breast(348;0.00765)|all_neural(195;0.0199)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)|Medulloblastoma(700;0.123)		Colorectal(126;3.12e-07)|COAD - Colon adenocarcinoma(152;1.21e-05)|STAD - Stomach adenocarcinoma(196;0.00395)|KIRC - Kidney renal clear cell carcinoma(1967;0.0249)|BRCA - Breast invasive adenocarcinoma(304;0.0289)|READ - Rectum adenocarcinoma(331;0.0757)		AAAATAGAAGTAAAAGAAGAA	0.388000													8	233					0	0	1	0	0
NUP153	9972	broad.mit.edu	37	6	17662260	17662260	+	Silent	SNP	T	T	C			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr6:17662260T>C	ENST00000262077.2	-	10	1256	c.1257A>G	c.(1255-1257)gaA>gaG	p.E419E	NUP153_ENST00000537253.1_Silent_p.E419E	NM_005124.2	NP_005115.2	P49790	NU153_HUMAN	nucleoporin 153kDa	419					carbohydrate metabolic process|glucose transport|interspecies interaction between organisms|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	cytoplasm|nuclear membrane|nuclear pore|nucleolus|nucleoplasm	DNA binding|protein binding|transporter activity|zinc ion binding			NS(2)|breast(6)|endometrium(4)|kidney(3)|large_intestine(7)|lung(23)|ovary(3)|skin(3)|urinary_tract(2)	53	Breast(50;0.0259)|Ovarian(93;0.0584)	all_hematologic(90;0.125)	all cancers(50;0.0981)|Epithelial(50;0.112)			TTTCTCGTTGTTCTCTATTTT	0.303000													86	137					0	0	1	0	0
KIF15	56992	broad.mit.edu	37	3	44856401	44856401	+	Splice_Site	SNP	A	A	T			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr3:44856401A>T	ENST00000326047.4	+	20	2532		c.e20-1		KIF15_ENST00000425755.1_Splice_Site	NM_020242.2	NP_064627.1	Q9NS87	KIF15_HUMAN	kinesin family member 15						blood coagulation|cell proliferation|microtubule-based movement|mitosis	centrosome|cytosol|microtubule|plus-end kinesin complex|spindle	ATP binding|DNA binding|microtubule motor activity			breast(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(7)|liver(2)|lung(9)|ovary(1)|prostate(4)|urinary_tract(5)	36				BRCA - Breast invasive adenocarcinoma(193;0.0099)|KIRC - Kidney renal clear cell carcinoma(197;0.0564)|Kidney(197;0.0707)		TTTGTTTTTTAGTTTTGAAAA	0.358000													5	100					0	0	1	0	0
CEP78	84131	broad.mit.edu	37	9	80856610	80856610	+	Splice_Site	SNP	A	A	T			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr9:80856610A>T	ENST00000424347.2	+	4	788		c.e4-1		CEP78_ENST00000277082.5_Splice_Site|CEP78_ENST00000415759.2_Splice_Site|CEP78_ENST00000376598.2_Splice_Site|CEP78_ENST00000376597.4_Splice_Site			Q5JTW2	CEP78_HUMAN	centrosomal protein 78kDa						G2/M transition of mitotic cell cycle	centrosome|cytosol				breast(1)|cervix(1)|endometrium(5)|large_intestine(7)|lung(4)|ovary(1)|stomach(1)|urinary_tract(1)	21						TTTCCATTTTAGTTATTTGTC	0.338000													6	98					0	0	1	0	0
ACLY	47	broad.mit.edu	37	17	40028034	40028034	+	Missense_Mutation	SNP	C	C	T			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr17:40028034C>T	ENST00000352035.2	-	25	2975	c.2845G>A	c.(2845-2847)Gcc>Acc	p.A949T	ACLY_ENST00000393896.2_Missense_Mutation_p.A939T|ACLY_ENST00000353196.1_Missense_Mutation_p.A939T|ACLY_ENST00000537919.1_Missense_Mutation_p.A678T|ACLY_ENST00000590151.1_Missense_Mutation_p.A949T	NM_001096.2	NP_001087.2	P53396	ACLY_HUMAN	ATP citrate lyase	949					ATP catabolic process|cellular carbohydrate metabolic process|citrate metabolic process|coenzyme A metabolic process|energy reserve metabolic process|long-chain fatty-acyl-CoA biosynthetic process|positive regulation of cellular metabolic process|triglyceride biosynthetic process	citrate lyase complex|cytosol|nucleus	ATP binding|ATP citrate synthase activity|citrate (pro-3S)-lyase activity|metal ion binding|protein binding|succinate-CoA ligase (ADP-forming) activity		NTN1/ACLY(2)	breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(5)|lung(4)|ovary(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	28		Breast(137;0.000143)				CTGTCAAAGGCTTTACTGAAC	0.502000													47	105					0	0	1	0	0
COL5A3	50509	broad.mit.edu	37	19	10116808	10116808	+	Missense_Mutation	SNP	C	C	T	rs144021089	byFrequency	TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr19:10116808C>T	ENST00000264828.3	-	2	273	c.188G>A	c.(187-189)cGg>cAg	p.R63Q		NM_015719.3	NP_056534.2	P25940	CO5A3_HUMAN	collagen, type V, alpha 3	63	TSP N-terminal.				collagen fibril organization|skin development	collagen type V	collagen binding|extracellular matrix structural constituent			NS(2)|breast(3)|central_nervous_system(2)|endometrium(11)|kidney(23)|large_intestine(12)|liver(2)|lung(35)|ovary(8)|prostate(5)|skin(10)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	116			Epithelial(33;7.11e-05)			TCTGAATGCCCGGTCACCCTC	0.657000													4	23					0	0	1	0	0
MSL1	339287	broad.mit.edu	37	17	38289885	38289885	+	Missense_Mutation	SNP	C	C	A			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr17:38289885C>A	ENST00000398532.3	+	7	1970	c.1655C>A	c.(1654-1656)aCc>aAc	p.T552N	MSL1_ENST00000578648.1_Missense_Mutation_p.T536N|MSL1_ENST00000579565.1_Missense_Mutation_p.T289N			Q68DK7	MSL1_HUMAN	male-specific lethal 1 homolog (Drosophila)	552					histone H4-K16 acetylation	MSL complex				endometrium(1)|kidney(2)|large_intestine(2)|lung(2)	7						CCTGAGGTTACCTCATTTTTC	0.433000													4	83					0.014758	0.0150192	1	1	0
GPR158	57512	broad.mit.edu	37	10	25887796	25887796	+	Missense_Mutation	SNP	A	A	C			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr10:25887796A>C	ENST00000376351.3	+	11	3600	c.3241A>C	c.(3241-3243)Att>Ctt	p.I1081L	GPR158_ENST00000490549.1_3'UTR	NM_020752.2	NP_065803.2	Q5T848	GP158_HUMAN	G protein-coupled receptor 158	1081						integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(5)|cervix(1)|endometrium(9)|kidney(10)|large_intestine(20)|lung(56)|ovary(4)|pancreas(1)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	119						AGGCCAGTCCATTTTGGAAGA	0.502000													73	203					0	0	1	0	0
NUP205	23165	broad.mit.edu	37	7	135307659	135307659	+	Missense_Mutation	SNP	C	C	T			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr7:135307659C>T	ENST00000285968.6	+	31	4491	c.4465C>T	c.(4465-4467)Cat>Tat	p.H1489Y		NM_015135.2	NP_055950.1	Q92621	NU205_HUMAN	nucleoporin 205kDa	1489					carbohydrate metabolic process|glucose transport|mRNA transport|protein import into nucleus, docking|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear pore	protein binding			breast(4)|central_nervous_system(2)|endometrium(9)|kidney(7)|large_intestine(17)|liver(4)|lung(36)|ovary(5)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	93						TTGTGATGGTCATGAGATTGG	0.388000													40	134					0	0	1	0	0
CYTH1	9267	broad.mit.edu	37	17	76692093	76692093	+	Splice_Site	SNP	T	T	A			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr17:76692093T>A	ENST00000589297.1	-	10	1327		c.e10-2		CYTH1_ENST00000591455.1_Intron|CYTH1_ENST00000585509.1_Splice_Site|CYTH1_ENST00000361101.4_Intron|CYTH1_ENST00000589296.1_Intron|CYTH1_ENST00000446868.3_Splice_Site			Q15438	CYH1_HUMAN	cytohesin 1						regulation of ARF protein signal transduction|regulation of cell adhesion|vesicle-mediated transport	cytoplasm|plasma membrane	ARF guanyl-nucleotide exchange factor activity|protein binding			endometrium(4)|kidney(1)|large_intestine(2)|lung(7)|ovary(1)|skin(2)|upper_aerodigestive_tract(2)	19						ACATACCTCCTGGAGTTTGGG	0.388000													42	84					0	0	1	0	0
AKAP9	10142	broad.mit.edu	37	7	91667731	91667731	+	Splice_Site	SNP	A	A	T			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr7:91667731A>T	ENST00000359028.2	+	18	4599		c.e18-1		AKAP9_ENST00000358100.2_Splice_Site|AKAP9_ENST00000356239.3_Splice_Site			Q99996	AKAP9_HUMAN	A kinase (PRKA) anchor protein 9						G2/M transition of mitotic cell cycle|signal transduction|synaptic transmission|transport	centrosome|cytosol|Golgi apparatus	receptor binding			NS(1)|autonomic_ganglia(2)|breast(14)|central_nervous_system(3)|cervix(1)|endometrium(13)|kidney(12)|large_intestine(35)|lung(49)|ovary(8)|prostate(6)|skin(8)|stomach(1)|urinary_tract(2)	155	all_cancers(62;2.46e-09)|all_epithelial(64;4.42e-08)|Breast(17;0.00206)|all_lung(186;0.185)|all_hematologic(106;0.215)|Lung NSC(181;0.249)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)			TTATTTCTTTAGGTTATTGTG	0.299000			T	BRAF	papillary thyroid								5	78					0	0	1	0	0
UXS1	80146	broad.mit.edu	37	2	106717553	106717553	+	Silent	SNP	C	C	A			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr2:106717553C>A	ENST00000283148.7	-	12	1042	c.945G>T	c.(943-945)gtG>gtT	p.V315V	UXS1_ENST00000428048.2_Silent_p.V154V|UXS1_ENST00000540130.1_Silent_p.V253V|UXS1_ENST00000409501.3_Silent_p.V310V|UXS1_ENST00000409032.1_Silent_p.V142V	NM_001253875.1|NM_025076.4	NP_001240804.1|NP_079352.2	Q8NBZ7	UXS1_HUMAN	UDP-glucuronate decarboxylase 1	310					cellular metabolic process	Golgi cisterna membrane|integral to membrane	coenzyme binding|UDP-glucuronate decarboxylase activity			cervix(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(7)|ovary(2)	17						TCATGAGAGCCACGAGGCCAT	0.557000													47	262					2.27781e-18	2.56812e-18	1	1	0
PPM1B	5495	broad.mit.edu	37	2	44457623	44457623	+	Missense_Mutation	SNP	T	T	G			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr2:44457623T>G	ENST00000282412.4	+	6	1618	c.1206T>G	c.(1204-1206)aaT>aaG	p.N402K	PPM1B_ENST00000378551.2_Intron|PPM1B_ENST00000378540.4_Intron|PPM1B_ENST00000345249.4_Missense_Mutation_p.N115K|PPM1B_ENST00000409432.3_3'UTR	NM_002706.4	NP_002697.1	O75688	PPM1B_HUMAN	protein phosphatase, Mg2+/Mn2+ dependent, 1B	402					protein dephosphorylation	protein serine/threonine phosphatase complex	magnesium ion binding|manganese ion binding|protein binding|protein serine/threonine phosphatase activity			kidney(4)|large_intestine(3)|lung(7)|skin(2)	16		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)				TGAGAATTAATCATAGGGGAA	0.473000													21	67					0	0	1	0	0
RPLP0P2	113157	broad.mit.edu	37	11	61404307	61404307	+	RNA	SNP	G	G	T			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr11:61404307G>T	ENST00000496593.1	+	0	911					NR_002775.2																						GCAAGGCCGTGGTGCTGATGG	0.552000													16	46					3.45872e-05	3.68289e-05	1	1	0
GRID1	2894	broad.mit.edu	37	10	87966299	87966299	+	Silent	SNP	G	G	C			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr10:87966299G>C	ENST00000327946.7	-	3	427	c.342C>G	c.(340-342)ctC>ctG	p.L114L		NM_017551.2	NP_060021.1	Q9ULK0	GRID1_HUMAN	glutamate receptor, ionotropic, delta 1	114						cell junction|integral to membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(24)|lung(46)|ovary(5)|prostate(4)|skin(5)|stomach(4)|upper_aerodigestive_tract(5)	106					L-Glutamic Acid(DB00142)	GCTGGACAAAGAGGTGTGGGA	0.632000										Multiple Myeloma(13;0.14)			50	117					0	0	1	0	0
DNAJB12	54788	broad.mit.edu	37	10	74100574	74100574	+	Silent	SNP	C	C	T			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr10:74100574C>T	ENST00000338820.3	-	5	947	c.798G>A	c.(796-798)agG>agA	p.R266R	DNAJB12_ENST00000461919.1_5'UTR|DNAJB12_ENST00000394903.2_Silent_p.R266R|DNAJB12_ENST00000444643.2_Silent_p.R232R	NM_001002762.2	NP_001002762.2	Q9NXW2	DJB12_HUMAN	DnaJ (Hsp40) homolog, subfamily B, member 12	232					protein folding	endoplasmic reticulum|integral to membrane	heat shock protein binding|unfolded protein binding			endometrium(1)|large_intestine(2)|skin(1)	4						TGCGGTCCTGCCTTTGCTGGT	0.642000													15	28					0	0	1	0	0
TRIM33	51592	broad.mit.edu	37	1	114967253	114967253	+	Missense_Mutation	SNP	C	C	A			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr1:114967253C>A	ENST00000358465.2	-	10	1903	c.1820G>T	c.(1819-1821)gGc>gTc	p.G607V	TRIM33_ENST00000450349.2_Missense_Mutation_p.G215V|TRIM33_ENST00000369543.2_Missense_Mutation_p.G607V	NM_015906.3	NP_056990.3	Q9UPN9	TRI33_HUMAN	tripartite motif containing 33	607					negative regulation of BMP signaling pathway|negative regulation of transcription, DNA-dependent|protein ubiquitination|regulation of transforming growth factor beta receptor signaling pathway|transcription, DNA-dependent	nucleus	co-SMAD binding|DNA binding|ligase activity|R-SMAD binding|zinc ion binding			breast(2)|central_nervous_system(5)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(10)|lung(14)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	48	all_epithelial(7;0.000132)|all_lung(7;0.00106)|Lung SC(450;0.184)	all_cancers(81;3.03e-08)|all_epithelial(167;3.24e-08)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		ATATTGAGGGCCGCTGTGCCT	0.433000			T	RET	papillary thyroid								61	130					9.12251e-31	1.04909e-30	1	1	0
SLIT2	9353	broad.mit.edu	37	4	20599967	20599967	+	Missense_Mutation	SNP	G	G	A			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr4:20599967G>A	ENST00000504154.1	+	33	3893	c.3641G>A	c.(3640-3642)cGt>cAt	p.R1214H	SLIT2_ENST00000503837.1_Missense_Mutation_p.R1210H|SLIT2_ENST00000503823.1_Missense_Mutation_p.R1206H|SLIT2_ENST00000273739.5_Missense_Mutation_p.R1227H	NM_004787.1	NP_004778.1	O94813	SLIT2_HUMAN	slit homolog 2 (Drosophila)	1214	Laminin G-like.				apoptosis involved in luteolysis|axon extension involved in axon guidance|branching morphogenesis of a tube|cell migration involved in sprouting angiogenesis|cellular response to heparin|cellular response to hormone stimulus|chemorepulsion involved in postnatal olfactory bulb interneuron migration|corticospinal neuron axon guidance through spinal cord|induction of negative chemotaxis|motor axon guidance|negative regulation of actin filament polymerization|negative regulation of cell growth|negative regulation of cellular response to growth factor stimulus|negative regulation of chemokine-mediated signaling pathway|negative regulation of endothelial cell migration|negative regulation of lamellipodium assembly|negative regulation of mononuclear cell migration|negative regulation of neutrophil chemotaxis|negative regulation of protein phosphorylation|negative regulation of retinal ganglion cell axon guidance|negative regulation of small GTPase mediated signal transduction|negative regulation of smooth muscle cell chemotaxis|negative regulation of vascular permeability|positive regulation of apoptosis|positive regulation of axonogenesis|response to cortisol stimulus|retinal ganglion cell axon guidance|Roundabout signaling pathway|ureteric bud development	cell surface|cytoplasm|extracellular space|plasma membrane	calcium ion binding|GTPase inhibitor activity|heparin binding|laminin-1 binding|protein homodimerization activity|proteoglycan binding|Roundabout binding			NS(1)|breast(4)|central_nervous_system(4)|cervix(1)|endometrium(5)|kidney(7)|large_intestine(17)|lung(60)|ovary(3)|pancreas(1)|prostate(2)|skin(10)|upper_aerodigestive_tract(1)	116						TATCGGGGGCGTGTTCGTGCC	0.473000													82	113					0	0	1	0	0
LDLR	3949	broad.mit.edu	37	19	11224382	11224382	+	Silent	SNP	G	G	A			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr19:11224382G>A	ENST00000558518.1	+	10	1717	c.1530G>A	c.(1528-1530)acG>acA	p.T510T	LDLR_ENST00000558013.1_Silent_p.T510T|LDLR_ENST00000557933.1_Silent_p.T510T|LDLR_ENST00000535915.1_Silent_p.T469T|LDLR_ENST00000545707.1_Silent_p.T383T|LDLR_ENST00000455727.2_Silent_p.T342T	NM_000527.4|NM_001195798.1	NP_000518.1|NP_001182727.1	P01130	LDLR_HUMAN	low density lipoprotein receptor	510					cholesterol homeostasis|cholesterol metabolic process|interspecies interaction between organisms|intestinal cholesterol absorption|low-density lipoprotein particle clearance|receptor-mediated endocytosis	clathrin-coated endocytic vesicle membrane|coated pit|early endosome|endosome membrane|external side of plasma membrane|integral to plasma membrane|low-density lipoprotein particle|lysosome	calcium ion binding|low-density lipoprotein receptor activity|protein binding|very-low-density lipoprotein particle receptor activity	p.?(1)		breast(2)|endometrium(2)|large_intestine(5)|lung(8)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	26		Lung NSC(9;0.000245)|Renal(1328;0.0007)|Hepatocellular(1079;0.0524)		GBM - Glioblastoma multiforme(1328;1.36e-05)|STAD - Stomach adenocarcinoma(1328;0.000766)|Lung(535;0.197)	Methyl aminolevulinate(DB00992)|Porfimer(DB00707)	AGAGGAAAACGTTATTCAGGG	0.582000													19	47					0	0	1	0	0
NCAPH2	29781	broad.mit.edu	37	22	50954874	50954874	+	Splice_Site	SNP	A	A	C			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr22:50954874A>C	ENST00000395701.3	+	2	202		c.e2-1		NCAPH2_ENST00000299821.11_Splice_Site|NCAPH2_ENST00000395698.3_Splice_Site|NCAPH2_ENST00000420993.2_Splice_Site			Q6IBW4	CNDH2_HUMAN	non-SMC condensin II complex, subunit H2						chromosome condensation	chromosome|nucleus				breast(1)|cervix(1)|endometrium(2)|kidney(3)|lung(10)|ovary(1)|prostate(2)|skin(3)|stomach(1)	24		all_cancers(38;4.58e-14)|all_epithelial(38;1.12e-12)|all_lung(38;3.07e-05)|Breast(42;6.27e-05)|Lung NSC(38;0.000813)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.212)		TGTTTCTTGCAGCTGGATCAG	0.537000													10	51					0	0	1	0	0
RBM43	375287	broad.mit.edu	37	2	152112099	152112099	+	Missense_Mutation	SNP	T	T	C			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr2:152112099T>C	ENST00000331426.5	-	2	313	c.162A>G	c.(160-162)atA>atG	p.I54M		NM_198557.2	NP_940959.1	Q6ZSC3	RBM43_HUMAN	RNA binding motif protein 43	54	RRM.						nucleotide binding|RNA binding			endometrium(2)|large_intestine(3)|lung(2)|ovary(1)	8				BRCA - Breast invasive adenocarcinoma(221;0.131)		TTGTCGGATATATCACATCTT	0.338000													59	132					0	0	1	0	0
AEBP2	121536	broad.mit.edu	37	12	19646732	19646732	+	Splice_Site	SNP	A	A	T			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr12:19646732A>T	ENST00000266508.9	+	4	988		c.e4-1		AEBP2_ENST00000398864.3_Splice_Site|AEBP2_ENST00000541908.1_Splice_Site|AEBP2_ENST00000360995.4_Splice_Site	NM_153207.4	NP_694939.2	Q6ZN18	AEBP2_HUMAN	AE binding protein 2						chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	ESC/E(Z) complex	DNA binding|zinc ion binding			ovary(1)	1	Acute lymphoblastic leukemia(4;0.000455)|all_hematologic(4;0.00804)|Esophageal squamous(101;0.143)					ATTTTCTTTTAGTGTGTTGTT	0.418000													8	61					0	0	1	0	0
RHOBTB1	9886	broad.mit.edu	37	10	62670706	62670706	+	Missense_Mutation	SNP	A	A	T			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr10:62670706A>T	ENST00000337910.5	-	4	572	c.235T>A	c.(235-237)Tct>Act	p.S79T	RHOBTB1_ENST00000357917.4_Missense_Mutation_p.S79T	NM_001242359.1|NM_014836.4	NP_001229288.1|NP_055651.1	O94844	RHBT1_HUMAN	Rho-related BTB domain containing 1	79	Rho-like.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|plasma membrane	GTP binding			endometrium(4)|large_intestine(6)|lung(11)|ovary(1)|upper_aerodigestive_tract(1)	23	Prostate(12;0.0112)					AGCCTGAGAGAAACACTCACT	0.488000													40	104					0	0	1	0	0
DCAF11	80344	broad.mit.edu	37	14	24587957	24587957	+	Splice_Site	SNP	A	A	T			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr14:24587957A>T	ENST00000446197.3	+	8	1451		c.e8-1		DCAF11_ENST00000396936.1_Splice_Site|DCAF11_ENST00000559115.1_Splice_Site|DCAF11_ENST00000396941.4_Splice_Site	NM_025230.4	NP_079506.3	Q8TEB1	DCA11_HUMAN	DDB1 and CUL4 associated factor 11							CUL4 RING ubiquitin ligase complex	protein binding										TGCTTCTCTTAGTTCATATCT	0.463000													13	314					0	0	1	0	0
WDR46	9277	broad.mit.edu	37	6	33254931	33254931	+	Missense_Mutation	SNP	C	C	T			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr6:33254931C>T	ENST00000374617.4	-	9	1308	c.952G>A	c.(952-954)Ggg>Agg	p.G318R		NM_001164267.1|NM_005452.5	NP_001157739.1|NP_005443.3	O15213	WDR46_HUMAN	WD repeat domain 46	318										NS(1)|breast(2)|kidney(1)|large_intestine(6)|lung(9)|prostate(1)	20						TCGAGCCGCCCAGCTCGAGCA	0.502000													56	150					0	0	1	0	0
SHROOM2	357	broad.mit.edu	37	X	9914789	9914789	+	Missense_Mutation	SNP	C	C	T			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chrX:9914789C>T	ENST00000380913.3	+	10	4753	c.4663C>T	c.(4663-4665)Cgc>Tgc	p.R1555C	SHROOM2_ENST00000418909.2_Missense_Mutation_p.R390C	NM_001649.2	NP_001640.1	Q13796	SHRM2_HUMAN	shroom family member 2	1555	ASD2.				apical protein localization|brain development|cell migration|cell morphogenesis|cellular pigment accumulation|ear development|establishment of melanosome localization|eye pigment granule organization|lens morphogenesis in camera-type eye|melanosome organization	apical plasma membrane|cell-cell adherens junction|microtubule|tight junction	actin filament binding|beta-catenin binding|ligand-gated sodium channel activity	p.R1555C(1)		breast(4)|central_nervous_system(2)|cervix(3)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(13)|ovary(3)|prostate(3)|skin(6)|upper_aerodigestive_tract(2)	57		Hepatocellular(5;0.000888)				CCTGGACCGCCGCGAGCGCAT	0.547000													8	18					0	0	1	0	0
CSTF3	1479	broad.mit.edu	37	11	33123767	33123767	+	Missense_Mutation	SNP	C	C	T			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr11:33123767C>T	ENST00000323959.4	-	10	921	c.782G>A	c.(781-783)aGc>aAc	p.S261N	TCP11L1_ENST00000324357.9_Intron	NM_001326.2	NP_001317.1	Q12996	CSTF3_HUMAN	cleavage stimulation factor, 3' pre-RNA, subunit 3, 77kDa	261					mRNA cleavage|mRNA polyadenylation|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	nucleoplasm	protein binding|RNA binding			breast(2)|endometrium(4)|kidney(1)|large_intestine(5)|lung(4)|prostate(1)|skin(1)|stomach(1)	19						AAGAGGGTTGCTCTTTTCCCA	0.433000													27	104					0	0	1	0	0
WDR66	144406	broad.mit.edu	37	12	122369710	122369710	+	Missense_Mutation	SNP	A	A	T			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr12:122369710A>T	ENST00000288912.4	+	4	1660	c.806A>T	c.(805-807)gAa>gTa	p.E269V	WDR66_ENST00000397454.2_Missense_Mutation_p.E269V	NM_144668.5	NP_653269.3	Q8TBY9	WDR66_HUMAN	WD repeat domain 66	269							calcium ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(11)|liver(2)|lung(13)|ovary(2)|prostate(2)|skin(2)|soft_tissue(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	43	all_neural(191;0.0496)|Medulloblastoma(191;0.0922)			OV - Ovarian serous cystadenocarcinoma(86;0.000155)|Epithelial(86;0.000634)|BRCA - Breast invasive adenocarcinoma(302;0.248)		ATTCGAGAGGAAAGGCAGAGA	0.453000													45	108					0	0	1	0	0
TMEM214	54867	broad.mit.edu	37	2	27256957	27256957	+	Silent	SNP	C	C	A			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr2:27256957C>A	ENST00000238788.9	+	2	236	c.174C>A	c.(172-174)acC>acA	p.T58T	TMEM214_ENST00000404032.3_Silent_p.T58T	NM_017727.4	NP_060197.4	Q6NUQ4	TM214_HUMAN	transmembrane protein 214	58						integral to membrane	protein binding			kidney(1)|large_intestine(5)|lung(9)|prostate(1)|skin(2)	18						CCACAAGCACCCTTTATGAGC	0.547000													91	160					7.22319e-40	8.39058e-40	1	1	0
C1S	716	broad.mit.edu	37	12	7172402	7172402	+	Splice_Site	SNP	A	A	T			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr12:7172402A>T	ENST00000406697.1	+	9	1145		c.e9-1		C1S_ENST00000328916.3_Splice_Site|C1S_ENST00000360817.5_Splice_Site|C1S_ENST00000402681.3_Splice_Site			P09871	C1S_HUMAN	complement component 1, s subcomponent						complement activation, classical pathway|innate immune response|proteolysis	extracellular region	calcium ion binding|serine-type endopeptidase activity			breast(1)|endometrium(5)|kidney(2)|large_intestine(8)|liver(4)|lung(8)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	33					Abciximab(DB00054)|Adalimumab(DB00051)|Basiliximab(DB00074)|Cetuximab(DB00002)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Rituximab(DB00073)|Trastuzumab(DB00072)	TTTCTCTGTTAGTTAATTGCA	0.418000													15	193					0	0	1	0	0
CTPS1	1503	broad.mit.edu	37	1	41471734	41471734	+	Missense_Mutation	SNP	A	A	G			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr1:41471734A>G	ENST00000372621.4	+	13	1772	c.1264A>G	c.(1264-1266)Aca>Gca	p.T422A	CTPS1_ENST00000541520.1_Missense_Mutation_p.T191A|CTPS1_ENST00000372616.1_Missense_Mutation_p.T422A	NM_001905.2	NP_001896.2	P17812	PYRG1_HUMAN	CTP synthase 1	422	Glutamine amidotransferase type-1.				CTP biosynthetic process|glutamine metabolic process|nucleobase, nucleoside and nucleotide interconversion|response to drug	cytosol	ATP binding|CTP synthase activity|protein binding			endometrium(3)|lung(10)	13					L-Glutamine(DB00130)	TGCCAATTCTACAGAGTTTGA	0.408000													37	117					0	0	1	0	0
POM121C	100101267	broad.mit.edu	37	7	75054987	75054987	+	Missense_Mutation	SNP	C	C	G			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr7:75054987C>G	ENST00000453279.2	-	9	1441	c.577G>C	c.(577-579)Gaa>Caa	p.E193Q	POM121C_ENST00000257665.5_Missense_Mutation_p.E435Q|POM121C_ENST00000473168.1_5'UTR	NM_001099415.1	NP_001092885.1	A8CG34	P121C_HUMAN	POM121 transmembrane nucleoporin C	435	Pore side (Potential).|Required for targeting to the nucleus and nuclear pore complex.				mRNA transport|protein transport|transmembrane transport	endoplasmic reticulum membrane|nuclear membrane|nuclear pore	protein binding			central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(6)|prostate(1)|skin(1)|urinary_tract(1)	14						CACAGCTCTTCTTCTCTGTTG	0.453000													11	21					0	0	1	0	0
FCAR	2204	broad.mit.edu	37	19	55399613	55399613	+	Missense_Mutation	SNP	C	C	T			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr19:55399613C>T	ENST00000355524.3	+	4	611	c.601C>T	c.(601-603)Ccc>Tcc	p.P201S	FCAR_ENST00000359272.4_Missense_Mutation_p.P189S|FCAR_ENST00000391724.3_Intron|FCAR_ENST00000482092.2_Intron|FCAR_ENST00000391723.3_Intron|FCAR_ENST00000469767.1_Missense_Mutation_p.P201S|FCAR_ENST00000391726.3_Intron|FCAR_ENST00000345937.4_Intron|FCAR_ENST00000353758.4_Missense_Mutation_p.P92S|FCAR_ENST00000391725.3_Intron	NM_002000.2	NP_001991.1	P24071	FCAR_HUMAN	Fc fragment of IgA, receptor for	201					immune response	extracellular region|integral to plasma membrane	IgA binding|receptor activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(14)|ovary(1)|skin(2)	24				GBM - Glioblastoma multiforme(193;0.0443)		CAACAGGAGCCCCTACCTGTG	0.582000													8	27					0	0	1	0	0
ESPNP	284729	broad.mit.edu	37	1	17023321	17023321	+	RNA	SNP	T	T	G			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr1:17023321T>G	ENST00000492551.1	-	0	1626					NR_026567.1																						GTCAGCCCCTTGCTCTGTGGC	0.637000													4	57					0	0	1	0	0
VHL	7428	broad.mit.edu	37	3	10191488	10191488	+	Nonsense_Mutation	SNP	C	C	T	rs5030818		TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr3:10191488C>T	ENST00000256474.2	+	3	1321	c.481C>T	c.(481-483)Cga>Tga	p.R161*	VHL_ENST00000345392.2_Nonsense_Mutation_p.R120*|VHL_ENST00000477538.1_3'UTR	NM_000551.3	NP_000542.1	P40337	VHL_HUMAN	von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase	161	Interaction with Elongin BC complex.		R -> G (in VHLD; type II; dbSNP:rs5030818).|R -> P (in pheochromocytoma and VHLD; type I).|R -> Q (in pheochromocytoma and VHLD; type II).		anti-apoptosis|cell morphogenesis|negative regulation of cell proliferation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of cell differentiation|positive regulation of transcription, DNA-dependent|protein stabilization|protein ubiquitination|proteolysis	cytosol|endoplasmic reticulum|membrane|mitochondrion|nucleus	protein binding|transcription factor binding	p.R161*(13)|p.E160fs*9(2)|p.R161del(1)|p.R161fs*13(1)|p.?fs(1)|p.L158fs*6(1)|p.E160fs*13(1)|p.R161fs*9(1)		adrenal_gland(25)|autonomic_ganglia(3)|central_nervous_system(2)|endometrium(6)|kidney(1662)|large_intestine(14)|lung(6)|pancreas(18)|paratesticular_tissues(1)|pleura(1)|skin(1)|soft_tissue(24)|thyroid(3)|upper_aerodigestive_tract(3)	1769				Kidney(1;0.000404)|KIRC - Kidney renal clear cell carcinoma(1;0.000569)		TCTGAAAGAGCGATGCCTCCA	0.502000		1	"""D, Mis, N, F, S"""		"""renal, hemangioma, pheochromocytoma"""	"""renal, hemangioma, pheochromocytoma"""			von Hippel-Lindau disease;Pheochromocytoma (Adrenal), Familial;Chuvash Polycythemia				18	38					0	0	1	0	0
WDR83	84292	broad.mit.edu	37	19	12783897	12783897	+	Missense_Mutation	SNP	T	T	A			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr19:12783897T>A	ENST00000418543.3	+	9	999	c.650T>A	c.(649-651)cTc>cAc	p.L217H	WDR83_ENST00000242796.4_Missense_Mutation_p.L217H	NM_001099737.2	NP_001093207.1	Q9BRX9	WDR83_HUMAN	WD repeat domain 83	217					nuclear mRNA splicing, via spliceosome	catalytic step 2 spliceosome|cytoplasm				breast(2)|large_intestine(1)|lung(1)	4						ACATTGCGGCTCCTGGACAAA	0.657000													42	86					0	0	1	0	0
CEBPZ	10153	broad.mit.edu	37	2	37428925	37428925	+	Silent	SNP	A	A	T	rs148813970	by1000genomes	TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr2:37428925A>T	ENST00000234170.5	-	16	3292	c.3147T>A	c.(3145-3147)acT>acA	p.T1049T	AC007390.5_ENST00000406711.1_Intron|AC007390.5_ENST00000397064.2_Intron|AC007390.5_ENST00000397226.2_Intron|AC007390.5_ENST00000402297.1_Intron|AC007390.5_ENST00000392061.2_Intron	NM_005760.2	NP_005751.2	Q03701	CEBPZ_HUMAN	CCAAT/enhancer binding protein (C/EBP), zeta	1049					regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleus	DNA binding			breast(3)|endometrium(2)|large_intestine(7)|lung(12)|ovary(1)|pancreas(1)|prostate(1)|skin(1)	28		all_hematologic(82;0.21)				TTTGTTTTTTAGTTTTTTGAG	0.294000													4	29					0	0	1	0	0
C10orf68	79741	broad.mit.edu	37	10	32974970	32974970	+	Missense_Mutation	SNP	T	T	A			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr10:32974970T>A	ENST00000375030.2	+	7	758	c.140T>A	c.(139-141)aTa>aAa	p.I47K	C10orf68_ENST00000375025.4_Missense_Mutation_p.I39K|C10orf68_ENST00000375028.3_Missense_Mutation_p.I53K			Q9H943	CJ068_HUMAN	chromosome 10 open reading frame 68	39										breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(15)|ovary(1)|skin(4)	29						AAATTACAAATAAAGAAACAA	0.289000													4	52					0	0	1	0	0
SETD2	29072	broad.mit.edu	37	3	47162162	47162162	+	Nonsense_Mutation	SNP	G	G	A			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr3:47162162G>A	ENST00000409792.3	-	3	4006	c.3964C>T	c.(3964-3966)Cga>Tga	p.R1322*		NM_014159.6	NP_054878.5	Q9BYW2	SETD2_HUMAN	SET domain containing 2	1322					regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	DNA binding|histone-lysine N-methyltransferase activity|oxidoreductase activity|transition metal ion binding	p.R819*(2)|p.R1322*(2)		breast(6)|central_nervous_system(5)|endometrium(4)|kidney(63)|large_intestine(18)|lung(26)|ovary(6)|prostate(2)|skin(3)|soft_tissue(1)|stomach(2)|urinary_tract(5)	141		Acute lymphoblastic leukemia(5;0.0169)		BRCA - Breast invasive adenocarcinoma(193;0.000302)|KIRC - Kidney renal clear cell carcinoma(197;0.00732)|Kidney(197;0.00844)		CCTTGAGTTCGATCATACACA	0.463000			"""N, F, S, Mis"""		clear cell renal carcinoma								57	106					0	0	1	0	0
MAEA	10296	broad.mit.edu	37	4	1305934	1305934	+	Silent	SNP	C	C	T			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr4:1305934C>T	ENST00000303400.4	+	2	300	c.237C>T	c.(235-237)agC>agT	p.S79S	MAEA_ENST00000505839.1_Silent_p.S31S|MAEA_ENST00000505177.2_Silent_p.S79S|MAEA_ENST00000264750.6_Silent_p.S79S|MAEA_ENST00000514708.1_Silent_p.S79S|MAEA_ENST00000510794.1_Silent_p.S78S|MAEA_ENST00000452175.2_Silent_p.S68S	NM_001017405.1	NP_001017405.1	Q7L5Y9	MAEA_HUMAN	macrophage erythroblast attacher	79	Extracellular and involved in cell to cell contact.				cell adhesion|cell cycle|cell division|erythrocyte maturation|negative regulation of myeloid cell apoptosis|regulation of mitotic cell cycle	actomyosin contractile ring|integral to plasma membrane|membrane fraction|nuclear matrix|spindle	actin binding			NS(2)|central_nervous_system(1)|endometrium(2)|large_intestine(5)|lung(2)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	18			OV - Ovarian serous cystadenocarcinoma(23;0.0201)			AGAAGCTCAGCGTCCTCAAGA	0.622000													15	28					0	0	1	0	0
TSHZ2	128553	broad.mit.edu	37	20	51870416	51870416	+	Missense_Mutation	SNP	G	G	A			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr20:51870416G>A	ENST00000371497.5	+	2	1306	c.419G>A	c.(418-420)gGc>gAc	p.G140D	TSHZ2_ENST00000329613.6_Missense_Mutation_p.G137D|TSHZ2_ENST00000603338.2_Missense_Mutation_p.G137D	NM_001193421.1|NM_173485.5	NP_001180350.1|NP_775756.3	Q9NRE2	TSH2_HUMAN	teashirt zinc finger homeobox 2	140					multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(2)|breast(4)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(16)|lung(38)|ovary(5)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	84			STAD - Stomach adenocarcinoma(23;0.1)			TACTGGTCAGGCCTGGGCCTT	0.512000													14	220					0	0	1	0	0
GRPEL1	80273	broad.mit.edu	37	4	7062876	7062876	+	Nonsense_Mutation	SNP	G	G	A			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr4:7062876G>A	ENST00000264954.4	-	4	531	c.367C>T	c.(367-369)Cag>Tag	p.Q123*	GRPEL1_ENST00000514056.1_5'UTR	NM_025196.2	NP_079472.1	Q9HAV7	GRPE1_HUMAN	GrpE-like 1, mitochondrial (E. coli)	123					protein folding|protein import into mitochondrial matrix	mitochondrial matrix	adenyl-nucleotide exchange factor activity|chaperone binding|protein homodimerization activity|unfolded protein binding			endometrium(1)|kidney(1)|large_intestine(2)|lung(1)	5						GGAACACACTGTGTTGCCTTC	0.463000													47	139					0	0	1	0	0
TRIM3	10612	broad.mit.edu	37	11	6479378	6479378	+	Missense_Mutation	SNP	C	C	T			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr11:6479378C>T	ENST00000525074.1	-	3	674	c.280G>A	c.(280-282)Gat>Aat	p.D94N	TRIM3_ENST00000537602.1_Missense_Mutation_p.D94N|TRIM3_ENST00000536344.1_5'UTR|TRIM3_ENST00000345851.3_Missense_Mutation_p.D94N|TRIM3_ENST00000359518.3_Missense_Mutation_p.D94N	NM_001248006.1	NP_001234935.1	O75382	TRIM3_HUMAN	tripartite motif containing 3	94					nervous system development|protein transport	early endosome	protein C-terminus binding|zinc ion binding			breast(1)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(8)|ovary(1)|prostate(2)|skin(3)	27		all_lung(207;9.97e-06)|Lung NSC(207;1.74e-05)|Medulloblastoma(188;0.00225)|Breast(177;0.0204)|all_neural(188;0.0212)		Epithelial(150;9.34e-10)|Lung(200;0.0234)|LUSC - Lung squamous cell carcinoma(625;0.133)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TGGGCCCCATCAGGTGCCTGC	0.647000													53	112					0	0	1	0	0
PCYOX1	51449	broad.mit.edu	37	2	70502098	70502098	+	Missense_Mutation	SNP	C	C	T			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr2:70502098C>T	ENST00000433351.2	+	4	530	c.502C>T	c.(502-504)Cgc>Tgc	p.R168C	PCYOX1_ENST00000264441.5_Missense_Mutation_p.R168C|PCYOX1_ENST00000505044.2_Missense_Mutation_p.R91C|PCYOX1_ENST00000545138.1_Missense_Mutation_p.R90C	NM_016297.3	NP_057381.3	Q9UHG3	PCYOX_HUMAN	prenylcysteine oxidase 1	168					prenylated protein catabolic process	lysosome|very-low-density lipoprotein particle	prenylcysteine oxidase activity			breast(1)|central_nervous_system(3)|endometrium(1)|kidney(1)|large_intestine(3)|lung(6)	15						AAGGATCTACCGCTACCAGTC	0.408000													7	221					0	0	1	0	0
STYK1	55359	broad.mit.edu	37	12	10783738	10783738	+	Silent	SNP	C	C	T			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr12:10783738C>T	ENST00000075503.3	-	5	877	c.357G>A	c.(355-357)caG>caA	p.Q119Q		NM_018423.2	NP_060893.2	Q6J9G0	STYK1_HUMAN	serine/threonine/tyrosine kinase 1	119	Protein kinase.					integral to membrane|plasma membrane	ATP binding|non-membrane spanning protein tyrosine kinase activity			breast(1)|central_nervous_system(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(1)|liver(1)|lung(8)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)	26						CACTGCAAATCTGCTCCAGAA	0.507000										HNSCC(73;0.22)			9	131					0	0	1	0	0
SUCO	51430	broad.mit.edu	37	1	172547460	172547460	+	Nonsense_Mutation	SNP	G	G	T			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr1:172547460G>T	ENST00000367723.3	+	13	1943	c.1819G>T	c.(1819-1821)Gaa>Taa	p.E607*	SUCO_ENST00000263688.3_Nonsense_Mutation_p.E455*	NM_016227.2	NP_057311.2			SUN domain containing ossification factor																		TAGCATGGTGGAAGAATATGA	0.368000													4	59					1	1	1	1	0
PREP	5550	broad.mit.edu	37	6	105800954	105800954	+	Splice_Site	SNP	T	T	A			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr6:105800954T>A	ENST00000369110.3	-	7	910		c.e7-2			NM_002726.4	NP_002717.3	P48147	PPCE_HUMAN	prolyl endopeptidase						proteolysis		serine-type endopeptidase activity			breast(1)|endometrium(2)|large_intestine(7)|lung(12)|ovary(3)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	29		all_cancers(87;0.000128)|Acute lymphoblastic leukemia(125;1.9e-08)|all_hematologic(75;9.25e-07)|all_epithelial(87;0.0344)|Lung NSC(302;0.191)|Colorectal(196;0.202)			Oxytocin(DB00107)	ATCAGATAACTAAAAAAGAAA	0.343000													10	151					0	0	1	0	0
SIPA1L3	23094	broad.mit.edu	37	19	38573642	38573642	+	Silent	SNP	C	C	T			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr19:38573642C>T	ENST00000222345.6	+	3	1946	c.1437C>T	c.(1435-1437)ccC>ccT	p.P479P		NM_015073.1	NP_055888.1	O60292	SI1L3_HUMAN	signal-induced proliferation-associated 1 like 3	479					regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			NS(1)|breast(3)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(8)|lung(22)|ovary(2)|prostate(4)|skin(3)	59			Lung(45;0.000246)|LUSC - Lung squamous cell carcinoma(53;0.000292)			TGGAAGTTCCCAAGGAGCAGC	0.672000													10	26					0	0	1	0	0
CEBPZ	10153	broad.mit.edu	37	2	37455860	37455860	+	Missense_Mutation	SNP	A	A	T			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr2:37455860A>T	ENST00000234170.5	-	2	621	c.476T>A	c.(475-477)gTa>gAa	p.V159E		NM_005760.2	NP_005751.2	Q03701	CEBPZ_HUMAN	CCAAT/enhancer binding protein (C/EBP), zeta	159					regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleus	DNA binding			breast(3)|endometrium(2)|large_intestine(7)|lung(12)|ovary(1)|pancreas(1)|prostate(1)|skin(1)	28		all_hematologic(82;0.21)				ATCTTTCTTTACTTTCGGTGT	0.363000													8	173					0	0	1	0	0
EEF1B2	1933	broad.mit.edu	37	2	207025358	207025358	+	Missense_Mutation	SNP	A	A	G			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr2:207025358A>G	ENST00000392222.2	+	2	502	c.127A>G	c.(127-129)Agc>Ggc	p.S43G	EEF1B2_ENST00000392221.1_Missense_Mutation_p.S43G|EEF1B2_ENST00000236957.5_Missense_Mutation_p.S43G	NM_001959.3	NP_001950.1	P24534	EF1B_HUMAN	eukaryotic translation elongation factor 1 beta 2	43	GST C-terminal.					cytosol|eukaryotic translation elongation factor 1 complex	protein binding|translation elongation factor activity	p.S43G(4)		breast(1)|endometrium(5)|kidney(3)|large_intestine(1)|lung(6)	16						AGCCGTGTCCAGCCCACCGCC	0.468000													4	70					0	0	1	0	0
ACSL3	2181	broad.mit.edu	37	2	223782769	223782769	+	Missense_Mutation	SNP	A	A	T			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr2:223782769A>T	ENST00000357430.3	+	6	1093	c.562A>T	c.(562-564)Aca>Tca	p.T188S	ACSL3_ENST00000392066.3_Missense_Mutation_p.T188S|AC097461.4_ENST00000446709.1_RNA	NM_004457.3	NP_004448.2	O95573	ACSL3_HUMAN	acyl-CoA synthetase long-chain family member 3	188					long-chain fatty-acyl-CoA biosynthetic process|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane|microsome|mitochondrial outer membrane|peroxisomal membrane	ATP binding|fatty-acyl-CoA synthase activity|long-chain fatty acid-CoA ligase activity|protein binding			cervix(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(5)|ovary(2)|prostate(1)|skin(2)	22		Renal(207;0.0183)		Epithelial(121;1.28e-10)|all cancers(144;8.06e-08)|Lung(261;0.00834)|LUSC - Lung squamous cell carcinoma(224;0.00864)	Icosapent(DB00159)	TTTAGTTGTTACATTATATGC	0.348000			T	ETV1	prostate								7	161					0	0	1	0	0
PPP2R2A	5520	broad.mit.edu	37	8	26221235	26221235	+	Splice_Site	SNP	A	A	T			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr8:26221235A>T	ENST00000380737.3	+	8	1131		c.e8-1		PPP2R2A_ENST00000315985.7_Splice_Site	NM_002717.3	NP_002708.1			protein phosphatase 2, regulatory subunit B, alpha											kidney(1)|large_intestine(2)|ovary(1)	4		all_cancers(63;0.086)|Ovarian(32;2.61e-05)|all_epithelial(46;0.0514)|Prostate(55;0.157)		UCEC - Uterine corpus endometrioid carcinoma (27;0.000754)|Epithelial(17;3.02e-15)|all cancers(2;1.52e-13)|OV - Ovarian serous cystadenocarcinoma(2;1.89e-10)|Colorectal(74;0.155)		ttttgttttTAGTGTTTGAAG	0.373000													4	25					0	0	1	0	0
CTDSPL2	51496	broad.mit.edu	37	15	44751187	44751187	+	Splice_Site	SNP	A	A	T			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr15:44751187A>T	ENST00000260327.4	+	2	539		c.e2-1		CTDSPL2_ENST00000558966.1_Splice_Site|CTDSPL2_ENST00000396780.1_Splice_Site	NM_016396.2	NP_057480.2	Q05D32	CTSL2_HUMAN	CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2								phosphoprotein phosphatase activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(4)|upper_aerodigestive_tract(2)	13		all_cancers(109;4.36e-14)|all_epithelial(112;9.8e-12)|Lung NSC(122;1.66e-07)|all_lung(180;1.47e-06)|Melanoma(134;0.0122)		all cancers(107;1.02e-20)|GBM - Glioblastoma multiforme(94;1.49e-06)|COAD - Colon adenocarcinoma(120;0.0857)|Colorectal(105;0.0905)		tttCTCTTTTAGTTTTACATG	0.343000													7	64					0	0	1	0	0
ASCC3	10973	broad.mit.edu	37	6	101095127	101095127	+	Silent	SNP	C	C	A			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr6:101095127C>A	ENST00000369162.2	-	21	3797	c.3453G>T	c.(3451-3453)ctG>ctT	p.L1151L		NM_006828.2	NP_006819.2	Q8N3C0	HELC1_HUMAN	activating signal cointegrator 1 complex subunit 3	1151	SEC63 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|microtubule cytoskeleton	ATP binding|ATP-dependent helicase activity|nucleic acid binding			breast(4)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(20)|liver(1)|lung(36)|ovary(6)|prostate(4)|skin(3)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	92		all_cancers(76;1.45e-07)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(87;0.00149)|Hepatocellular(1;0.0893)|Colorectal(196;0.13)		BRCA - Breast invasive adenocarcinoma(108;0.0539)|all cancers(137;0.103)|GBM - Glioblastoma multiforme(226;0.199)		TCATGTCTTTCAGCTTATCCA	0.368000													8	72					1.12685e-05	1.2111e-05	1	1	0
COL11A2	1302	broad.mit.edu	37	6	33140387	33140387	+	Missense_Mutation	SNP	C	C	A			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr6:33140387C>A	ENST00000341947.2	-	39	3045	c.2818G>T	c.(2818-2820)Ggg>Tgg	p.G940W	COL11A2_ENST00000395197.1_Missense_Mutation_p.G880W|COL11A2_ENST00000374712.1_Missense_Mutation_p.G859W|COL11A2_ENST00000357486.1_Missense_Mutation_p.G919W|COL11A2_ENST00000374713.1_Missense_Mutation_p.G893W|COL11A2_ENST00000477772.1_Intron|COL11A2_ENST00000361917.1_Missense_Mutation_p.G833W|COL11A2_ENST00000374708.4_Missense_Mutation_p.G854W|COL11A2_ENST00000374714.1_Missense_Mutation_p.G914W	NM_080680.2	NP_542411.2	P13942	COBA2_HUMAN	collagen, type XI, alpha 2	940	Triple-helical region.		Missing (in STL3).		cartilage development|cell adhesion|collagen fibril organization|sensory perception of sound|soft palate development	collagen type XI	extracellular matrix structural constituent conferring tensile strength|protein binding, bridging			biliary_tract(1)|breast(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|liver(1)|lung(27)|ovary(5)|prostate(5)|skin(6)	68						CCTCTCTCCCCCATAGGGCCG	0.627000													19	38					1.36565e-18	1.55494e-18	1	1	0
ITPR2	3709	broad.mit.edu	37	12	26848561	26848561	+	Missense_Mutation	SNP	G	G	C			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr12:26848561G>C	ENST00000381340.3	-	10	1390	c.974C>G	c.(973-975)gCc>gGc	p.A325G		NM_002223.2	NP_002214.2	Q14571	ITPR2_HUMAN	inositol 1,4,5-trisphosphate receptor, type 2	325	MIR 4.				activation of phospholipase C activity|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	integral to membrane|plasma membrane enriched fraction|platelet dense tubular network membrane|sarcoplasmic reticulum membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity		ETV6/ITPR2(2)	biliary_tract(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(16)|large_intestine(20)|liver(1)|lung(51)|ovary(5)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(5)|urinary_tract(3)	125	Colorectal(261;0.0847)					TTCATTTTGGGCATCTCGATA	0.303000													18	86					0	0	1	0	0
HMCN1	83872	broad.mit.edu	37	1	186086589	186086589	+	Splice_Site	SNP	A	A	T			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr1:186086589A>T	ENST00000271588.4	+	77	11912		c.e77-1		HMCN1_ENST00000367492.2_Splice_Site	NM_031935.2	NP_114141.2	Q96RW7	HMCN1_HUMAN	hemicentin 1						response to stimulus|visual perception	basement membrane	calcium ion binding			NS(2)|autonomic_ganglia(1)|breast(10)|central_nervous_system(2)|cervix(1)|endometrium(28)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(58)|liver(3)|lung(101)|ovary(23)|pancreas(4)|prostate(20)|skin(8)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(18)	308						TTGTTGTTTTAGTTCCACCTT	0.403000													6	103					0	0	1	0	0
TOPORS	10210	broad.mit.edu	37	9	32541877	32541877	+	Missense_Mutation	SNP	A	A	T			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr9:32541877A>T	ENST00000360538.2	-	3	2762	c.2646T>A	c.(2644-2646)caT>caA	p.H882Q	TOPORS_ENST00000379858.1_Missense_Mutation_p.H817Q	NM_005802.4	NP_005793.2	Q9NS56	TOPRS_HUMAN	topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase	882	Interaction with TOP1.|Interaction with UBE2I.|Lys-rich.				DNA damage response, signal transduction resulting in induction of apoptosis|maintenance of protein location in nucleus|proteasomal ubiquitin-dependent protein catabolic process|protein sumoylation|transcription, DNA-dependent	nuclear speck|PML body	antigen binding|DNA binding|DNA topoisomerase I binding|SUMO ligase activity|ubiquitin-protein ligase activity|zinc ion binding			large_intestine(6)|ovary(3)|skin(2)|upper_aerodigestive_tract(1)	12			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.0018)		ttttctttttATGGTGTTTAG	0.373000													16	370					0	0	1	0	0
SLC35F1	222553	broad.mit.edu	37	6	118635189	118635189	+	Splice_Site	SNP	A	A	T			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr6:118635189A>T	ENST00000360388.4	+	8	1203		c.e8-1			NM_001029858.3	NP_001025029.2	Q5T1Q4	S35F1_HUMAN	solute carrier family 35, member F1						transport	integral to membrane				breast(3)|kidney(1)|large_intestine(7)|lung(21)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	36				GBM - Glioblastoma multiforme(226;0.217)		GTGTTTTTTTAGTTTTCAGGA	0.473000													5	101					0	0	1	0	0
TAF3	83860	broad.mit.edu	37	10	8006092	8006092	+	Missense_Mutation	SNP	G	G	T			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	14591343-b381-43d0-aea0-0e02221c09c6	g.chr10:8006092G>T	ENST00000344293.5	+	3	825	c.619G>T	c.(619-621)Gtt>Ttt	p.V207F		NM_031923.3	NP_114129.1	Q5VWG9	TAF3_HUMAN	TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 140kDa	207					maintenance of protein location in nucleus|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	transcription factor TFIID complex	protein binding|zinc ion binding			NS(2)|breast(4)|endometrium(2)|kidney(1)|large_intestine(6)|lung(16)|ovary(3)|prostate(4)|skin(2)	40						CACGCTAGATGTTGTGTTATT	0.488000													18	162					8.04996e-18	8.95558e-18	1	1	0
CT47B1	643311	broad.mit.edu	37	X	120007830	120007830	+	Missense_Mutation	SNP	C	C	T			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	14591343-b381-43d0-aea0-0e02221c09c6	g.chrX:120007830C>T	ENST00000371311.3	-	2	1074	c.820G>A	c.(820-822)Gat>Aat	p.D274N		NM_001145718.1	NP_001139190.1	P0C2W7	CT47B_HUMAN	cancer/testis antigen family 47, member B1	274										breast(1)|central_nervous_system(1)|endometrium(7)|kidney(2)|lung(9)|ovary(1)|skin(1)	22						CCTGCAGCATCTTGGGCCTCT	0.463000													25	556					0	0	1	0	0
GLS2	27165	broad.mit.edu	37	12	56871719	56871719	+	Missense_Mutation	SNP	T	T	G			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	14591343-b381-43d0-aea0-0e02221c09c6	g.chr12:56871719T>G	ENST00000311966.4	-	6	1054	c.776A>C	c.(775-777)gAa>gCa	p.E259A		NM_013267.2	NP_037399.2	Q9UI32	GLSL_HUMAN	glutaminase 2 (liver, mitochondrial)	259					cellular amino acid biosynthetic process|glutamate secretion|glutamine metabolic process|neurotransmitter secretion	mitochondrial matrix	glutaminase activity|protein binding			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(4)|ovary(1)|stomach(1)|urinary_tract(1)	13					L-Glutamic Acid(DB00142)|L-Glutamine(DB00130)	GTGCTCACCTTCCTCATTGAG	0.527000													13	365					0	0	1	0	0
ANK1	286	broad.mit.edu	37	8	41559142	41559142	+	Splice_Site	SNP	T	T	A			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	14591343-b381-43d0-aea0-0e02221c09c6	g.chr8:41559142T>A	ENST00000396942.1	-	22	2472		c.e22-2		ANK1_ENST00000289734.7_Splice_Site|ANK1_ENST00000379758.2_Splice_Site|ANK1_ENST00000396945.1_Splice_Site|ANK1_ENST00000352337.4_Splice_Site|ANK1_ENST00000347528.4_Splice_Site|ANK1_ENST00000265709.8_Splice_Site			P16157	ANK1_HUMAN	ankyrin 1, erythrocytic						axon guidance|cytoskeleton organization|exocytosis|maintenance of epithelial cell apical/basal polarity|signal transduction	basolateral plasma membrane|cytosol|sarcomere|sarcoplasmic reticulum|spectrin-associated cytoskeleton	cytoskeletal adaptor activity|enzyme binding|protein binding|spectrin binding|structural constituent of cytoskeleton			breast(5)|central_nervous_system(4)|endometrium(9)|kidney(1)|large_intestine(26)|lung(62)|ovary(3)|prostate(5)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	122	Ovarian(28;0.00541)|Colorectal(14;0.0398)|Lung SC(25;0.211)	all_lung(54;0.000626)|Lung NSC(58;0.00245)|Esophageal squamous(32;0.0559)|Hepatocellular(245;0.0663)|Renal(179;0.188)	OV - Ovarian serous cystadenocarcinoma(14;0.000984)|Lung(22;0.00108)|Colorectal(10;0.00245)|LUSC - Lung squamous cell carcinoma(45;0.00392)|COAD - Colon adenocarcinoma(11;0.0264)			ACTGACTAACTAAAACGAGAA	0.468000											OREG0018740	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	5	92					0	0	1	0	0
ITPR2	3709	broad.mit.edu	37	12	26848562	26848562	+	Missense_Mutation	SNP	C	C	T			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	14591343-b381-43d0-aea0-0e02221c09c6	g.chr12:26848562C>T	ENST00000381340.3	-	10	1389	c.973G>A	c.(973-975)Gcc>Acc	p.A325T		NM_002223.2	NP_002214.2	Q14571	ITPR2_HUMAN	inositol 1,4,5-trisphosphate receptor, type 2	325	MIR 4.				activation of phospholipase C activity|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	integral to membrane|plasma membrane enriched fraction|platelet dense tubular network membrane|sarcoplasmic reticulum membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity		ETV6/ITPR2(2)	biliary_tract(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(16)|large_intestine(20)|liver(1)|lung(51)|ovary(5)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(5)|urinary_tract(3)	125	Colorectal(261;0.0847)					TCATTTTGGGCATCTCGATAA	0.299000													18	84					0	0	1	0	0
MYH2	4620	broad.mit.edu	37	17	10442759	10442759	+	Splice_Site	SNP	A	A	G			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	14591343-b381-43d0-aea0-0e02221c09c6	g.chr17:10442759A>G	ENST00000245503.5	-	13	1651		c.e13+1		CTC-297N7.7_ENST00000587182.1_RNA|MYH2_ENST00000397183.2_Splice_Site|MYH2_ENST00000532183.1_Splice_Site	NM_017534.5	NP_060004.3	Q9UKX2	MYH2_HUMAN	myosin, heavy chain 2, skeletal muscle, adult						muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(16)|lung(99)|ovary(6)|pancreas(4)|prostate(3)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(4)	176						TTATGCACCTACCTGTTCTAC	0.443000													91	235					0	0	1	0	0
RBBP6	5930	broad.mit.edu	37	16	24564874	24564874	+	Missense_Mutation	SNP	C	C	A			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	14591343-b381-43d0-aea0-0e02221c09c6	g.chr16:24564874C>A	ENST00000319715.4	+	4	776	c.344C>A	c.(343-345)aCa>aAa	p.T115K	RBBP6_ENST00000381039.3_Missense_Mutation_p.T115K|RBBP6_ENST00000348022.2_Missense_Mutation_p.T115K	NM_006910.4	NP_008841.2	Q7Z6E9	RBBP6_HUMAN	retinoblastoma binding protein 6	115					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	chromosome|nucleolus|ubiquitin ligase complex	nucleic acid binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(10)|lung(17)|ovary(4)|pancreas(1)|prostate(2)|urinary_tract(1)	46				GBM - Glioblastoma multiforme(48;0.0518)		GCCCAGCTTACAAAGGTATAT	0.323000													10	53					0.000978159	0.00102419	1	1	0
GRHL1	29841	broad.mit.edu	37	2	10101473	10101473	+	Missense_Mutation	SNP	G	G	C			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	14591343-b381-43d0-aea0-0e02221c09c6	g.chr2:10101473G>C	ENST00000324907.9	+	4	713	c.577G>C	c.(577-579)Gac>Cac	p.D193H	GRHL1_ENST00000324883.5_Silent_p.L29L|GRHL1_ENST00000405379.2_Missense_Mutation_p.D193H	NM_198182.2	NP_937825.2	Q9NZI5	GRHL1_HUMAN	grainyhead-like 1 (Drosophila)	193					cellular lipid metabolic process|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	Golgi apparatus|nucleus	DNA binding			cervix(1)|endometrium(1)|large_intestine(2)|lung(8)|ovary(1)|pancreas(1)|skin(1)|stomach(1)|urinary_tract(1)	17	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.172)|OV - Ovarian serous cystadenocarcinoma(76;0.246)		TCTCAATACTGACCAGTTCAG	0.542000													51	146					0	0	1	0	0
PITX2	5308	broad.mit.edu	37	4	111539589	111539589	+	Missense_Mutation	SNP	A	A	T			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	14591343-b381-43d0-aea0-0e02221c09c6	g.chr4:111539589A>T	ENST00000354925.2	-	7	2351	c.646T>A	c.(646-648)Tct>Act	p.S216T	PITX2_ENST00000355080.5_Missense_Mutation_p.S170T|PITX2_ENST00000394595.3_Missense_Mutation_p.L147H|PITX2_ENST00000394598.2_Missense_Mutation_p.S216T|PITX2_ENST00000306732.3_Missense_Mutation_p.S223T	NM_001204397.1	NP_001191326.1	Q99697	PITX2_HUMAN	paired-like homeodomain 2	216					determination of left/right symmetry|organ morphogenesis	transcription factor complex	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding			breast(1)|endometrium(3)|large_intestine(1)|lung(5)	10		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.00222)		GACGAGATAGAGTTGGGTGGG	0.547000													55	138					0	0	1	0	0
PCF11	51585	broad.mit.edu	37	11	82877725	82877725	+	Missense_Mutation	SNP	A	A	G			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	14591343-b381-43d0-aea0-0e02221c09c6	g.chr11:82877725A>G	ENST00000298281.4	+	5	2238	c.1786A>G	c.(1786-1788)Aga>Gga	p.R596G		NM_015885.3	NP_056969.2	O94913	PCF11_HUMAN	PCF11 cleavage and polyadenylation factor subunit	596					mRNA 3'-end processing|mRNA cleavage|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	mRNA cleavage factor complex		p.R695R(1)|p.R596R(1)		cervix(1)|endometrium(3)|kidney(4)|large_intestine(1)|lung(22)|ovary(1)|urinary_tract(1)	33						GTCTGCCAAAAGATGGAAATC	0.348000													47	141					0	0	1	0	0
DOCK4	9732	broad.mit.edu	37	7	111555908	111555908	+	Missense_Mutation	SNP	C	C	T			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	14591343-b381-43d0-aea0-0e02221c09c6	g.chr7:111555908C>T	ENST00000428084.1	-	13	1390	c.1118G>A	c.(1117-1119)aGg>aAg	p.R373K	DOCK4_ENST00000437633.1_Missense_Mutation_p.R373K|DOCK4_ENST00000476846.1_5'UTR			Q8N1I0	DOCK4_HUMAN	dedicator of cytokinesis 4	373					cell chemotaxis	cytosol|endomembrane system|membrane|stereocilium	GTP binding|guanyl-nucleotide exchange factor activity|PDZ domain binding|Rac GTPase activator activity|Rac GTPase binding|receptor tyrosine kinase binding|SH3 domain binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(4)|kidney(4)|large_intestine(13)|lung(31)|ovary(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(4)	72		Acute lymphoblastic leukemia(1;0.0441)				TGAATATTCCCTTCTGATTTG	0.368000													7	31					0	0	1	0	0
C14orf37	145407	broad.mit.edu	37	14	58604706	58604706	+	Splice_Site	SNP	A	A	T			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	14591343-b381-43d0-aea0-0e02221c09c6	g.chr14:58604706A>T	ENST00000267485.7	-	2	1564		c.e2+1		C14orf37_ENST00000334342.5_Splice_Site	NM_001001872.2	NP_001001872.2	Q86TY3	CN037_HUMAN	chromosome 14 open reading frame 37							integral to membrane	binding			breast(7)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(16)|pancreas(1)|skin(1)	33						TCTTTCTTTTACCTTTCATTG	0.323000													6	116					0	0	1	0	0
SPAG5	10615	broad.mit.edu	37	17	26919344	26919344	+	Silent	SNP	T	T	C	rs113667723	byFrequency	TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	14591343-b381-43d0-aea0-0e02221c09c6	g.chr17:26919344T>C	ENST00000321765.5	-	3	1250	c.918A>G	c.(916-918)acA>acG	p.T306T		NM_006461.3	NP_006452.3	Q96R06	SPAG5_HUMAN	sperm associated antigen 5	306					cell division|mitosis|phosphatidylinositol-mediated signaling|spindle organization	condensed chromosome kinetochore|cytoplasm|spindle pole	protein binding			NS(1)|breast(3)|central_nervous_system(1)|endometrium(5)|kidney(4)|large_intestine(8)|lung(17)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	43	Lung NSC(42;0.00431)					GTGTCAGGCATGTGGACAGAA	0.453000													8	215					0	0	1	0	0
BUB1B	701	broad.mit.edu	37	15	40505655	40505655	+	Silent	SNP	G	G	A	rs146821149		TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	14591343-b381-43d0-aea0-0e02221c09c6	g.chr15:40505655G>A	ENST00000287598.6	+	20	2853	c.2658G>A	c.(2656-2658)agG>agA	p.R886R	BUB1B_ENST00000412359.3_Silent_p.R900R	NM_001211.5	NP_001202.4	O60566	BUB1B_HUMAN	BUB1 mitotic checkpoint serine/threonine kinase B	886	Protein kinase.				anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|cell division|cell proliferation|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|phosphatidylinositol-mediated signaling|protein localization to kinetochore|spindle organization	anaphase-promoting complex|condensed chromosome outer kinetochore|cytosol|microtubule organizing center|perinuclear region of cytoplasm|spindle midzone	ATP binding|protein binding|protein serine/threonine kinase activity			breast(2)|endometrium(1)|kidney(2)|large_intestine(7)|liver(2)|lung(17)|ovary(1)|stomach(2)|urinary_tract(2)	36		all_cancers(109;1.12e-18)|all_epithelial(112;1.61e-15)|Lung NSC(122;5.63e-11)|all_lung(180;1.4e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;1.83e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0556)		TGAGTCCAAGGTGTCTGATTC	0.348000			"""Mis, N, F, S"""			rhabdomyosarcoma			Mosaic Variegated Aneuploidy Syndrome				42	79					0	0	1	0	0
NEURL3	93082	broad.mit.edu	37	2	97164150	97164150	+	RNA	SNP	T	T	C			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	14591343-b381-43d0-aea0-0e02221c09c6	g.chr2:97164150T>C	ENST00000310865.3	-	0	942									neuralized E3 ubiquitin protein ligase 3																		GGCAGCGTGATAGAAGCAGAT	0.607000													36	63					0	0	1	0	0
POM121L9P	29774	broad.mit.edu	37	22	24659734	24659734	+	RNA	SNP	T	T	C			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	14591343-b381-43d0-aea0-0e02221c09c6	g.chr22:24659734T>C	ENST00000414583.2	+	0	3259					NR_003714.1																						CTCTCTCCTGTGGGAGGGGGG	0.632000													3	22					0	0	1	0	0
SATB2	23314	broad.mit.edu	37	2	200173596	200173596	+	Missense_Mutation	SNP	G	G	A			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	14591343-b381-43d0-aea0-0e02221c09c6	g.chr2:200173596G>A	ENST00000443023.1	-	9	2915	c.1450C>T	c.(1450-1452)Cgc>Tgc	p.R484C	SATB2_ENST00000428695.1_Missense_Mutation_p.R425C|SATB2_ENST00000417098.1_Missense_Mutation_p.R543C|SATB2_ENST00000260926.5_Missense_Mutation_p.R543C|SATB2_ENST00000457245.1_Missense_Mutation_p.R543C			Q9UPW6	SATB2_HUMAN	SATB homeobox 2	543						cytoplasm|nuclear matrix	sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|lung(40)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	62						TTCAGGAAGCGACGGATGGTA	0.577000													18	311					0	0	1	0	0
NUP153	9972	broad.mit.edu	37	6	17662260	17662260	+	Silent	SNP	T	T	C			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	14591343-b381-43d0-aea0-0e02221c09c6	g.chr6:17662260T>C	ENST00000262077.2	-	10	1256	c.1257A>G	c.(1255-1257)gaA>gaG	p.E419E	NUP153_ENST00000537253.1_Silent_p.E419E	NM_005124.2	NP_005115.2	P49790	NU153_HUMAN	nucleoporin 153kDa	419					carbohydrate metabolic process|glucose transport|interspecies interaction between organisms|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	cytoplasm|nuclear membrane|nuclear pore|nucleolus|nucleoplasm	DNA binding|protein binding|transporter activity|zinc ion binding			NS(2)|breast(6)|endometrium(4)|kidney(3)|large_intestine(7)|lung(23)|ovary(3)|skin(3)|urinary_tract(2)	53	Breast(50;0.0259)|Ovarian(93;0.0584)	all_hematologic(90;0.125)	all cancers(50;0.0981)|Epithelial(50;0.112)			TTTCTCGTTGTTCTCTATTTT	0.303000													86	137					0	0	1	0	0
NCAPH2	29781	broad.mit.edu	37	22	50954874	50954874	+	Splice_Site	SNP	A	A	C			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	14591343-b381-43d0-aea0-0e02221c09c6	g.chr22:50954874A>C	ENST00000395701.3	+	2	202		c.e2-1		NCAPH2_ENST00000420993.2_Splice_Site|NCAPH2_ENST00000299821.11_Splice_Site|NCAPH2_ENST00000395698.3_Splice_Site			Q6IBW4	CNDH2_HUMAN	non-SMC condensin II complex, subunit H2						chromosome condensation	chromosome|nucleus				breast(1)|cervix(1)|endometrium(2)|kidney(3)|lung(10)|ovary(1)|prostate(2)|skin(3)|stomach(1)	24		all_cancers(38;4.58e-14)|all_epithelial(38;1.12e-12)|all_lung(38;3.07e-05)|Breast(42;6.27e-05)|Lung NSC(38;0.000813)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.212)		TGTTTCTTGCAGCTGGATCAG	0.537000													10	51					0	0	1	0	0
ACLY	47	broad.mit.edu	37	17	40028034	40028034	+	Missense_Mutation	SNP	C	C	T			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	14591343-b381-43d0-aea0-0e02221c09c6	g.chr17:40028034C>T	ENST00000352035.2	-	25	2975	c.2845G>A	c.(2845-2847)Gcc>Acc	p.A949T	ACLY_ENST00000393896.2_Missense_Mutation_p.A939T|ACLY_ENST00000537919.1_Missense_Mutation_p.A678T|ACLY_ENST00000353196.1_Missense_Mutation_p.A939T|ACLY_ENST00000590151.1_Missense_Mutation_p.A949T	NM_001096.2	NP_001087.2	P53396	ACLY_HUMAN	ATP citrate lyase	949					ATP catabolic process|cellular carbohydrate metabolic process|citrate metabolic process|coenzyme A metabolic process|energy reserve metabolic process|long-chain fatty-acyl-CoA biosynthetic process|positive regulation of cellular metabolic process|triglyceride biosynthetic process	citrate lyase complex|cytosol|nucleus	ATP binding|ATP citrate synthase activity|citrate (pro-3S)-lyase activity|metal ion binding|protein binding|succinate-CoA ligase (ADP-forming) activity		NTN1/ACLY(2)	breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(5)|lung(4)|ovary(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	28		Breast(137;0.000143)				CTGTCAAAGGCTTTACTGAAC	0.502000													47	105					0	0	1	0	0
MSL1	339287	broad.mit.edu	37	17	38289885	38289885	+	Missense_Mutation	SNP	C	C	A			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	14591343-b381-43d0-aea0-0e02221c09c6	g.chr17:38289885C>A	ENST00000398532.3	+	7	1970	c.1655C>A	c.(1654-1656)aCc>aAc	p.T552N	MSL1_ENST00000579565.1_Missense_Mutation_p.T289N|MSL1_ENST00000578648.1_Missense_Mutation_p.T536N			Q68DK7	MSL1_HUMAN	male-specific lethal 1 homolog (Drosophila)	552					histone H4-K16 acetylation	MSL complex				endometrium(1)|kidney(2)|large_intestine(2)|lung(2)	7						CCTGAGGTTACCTCATTTTTC	0.433000													4	83					0.014758	0.0150973	1	1	0
GPR158	57512	broad.mit.edu	37	10	25887796	25887796	+	Missense_Mutation	SNP	A	A	C			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	14591343-b381-43d0-aea0-0e02221c09c6	g.chr10:25887796A>C	ENST00000376351.3	+	11	3600	c.3241A>C	c.(3241-3243)Att>Ctt	p.I1081L	GPR158_ENST00000490549.1_3'UTR	NM_020752.2	NP_065803.2	Q5T848	GP158_HUMAN	G protein-coupled receptor 158	1081						integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(5)|cervix(1)|endometrium(9)|kidney(10)|large_intestine(20)|lung(56)|ovary(4)|pancreas(1)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	119						AGGCCAGTCCATTTTGGAAGA	0.502000													73	203					0	0	1	0	0
NUP205	23165	broad.mit.edu	37	7	135307659	135307659	+	Missense_Mutation	SNP	C	C	T			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	14591343-b381-43d0-aea0-0e02221c09c6	g.chr7:135307659C>T	ENST00000285968.6	+	31	4491	c.4465C>T	c.(4465-4467)Cat>Tat	p.H1489Y		NM_015135.2	NP_055950.1	Q92621	NU205_HUMAN	nucleoporin 205kDa	1489					carbohydrate metabolic process|glucose transport|mRNA transport|protein import into nucleus, docking|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear pore	protein binding			breast(4)|central_nervous_system(2)|endometrium(9)|kidney(7)|large_intestine(17)|liver(4)|lung(36)|ovary(5)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	93						TTGTGATGGTCATGAGATTGG	0.388000													40	134					0	0	1	0	0
UXS1	80146	broad.mit.edu	37	2	106717553	106717553	+	Silent	SNP	C	C	A			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	14591343-b381-43d0-aea0-0e02221c09c6	g.chr2:106717553C>A	ENST00000283148.7	-	12	1042	c.945G>T	c.(943-945)gtG>gtT	p.V315V	UXS1_ENST00000409032.1_Silent_p.V142V|UXS1_ENST00000540130.1_Silent_p.V253V|UXS1_ENST00000428048.2_Silent_p.V154V|UXS1_ENST00000409501.3_Silent_p.V310V	NM_001253875.1|NM_025076.4	NP_001240804.1|NP_079352.2	Q8NBZ7	UXS1_HUMAN	UDP-glucuronate decarboxylase 1	310					cellular metabolic process	Golgi cisterna membrane|integral to membrane	coenzyme binding|UDP-glucuronate decarboxylase activity			cervix(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(7)|ovary(2)	17						TCATGAGAGCCACGAGGCCAT	0.557000													47	262					2.27781e-18	2.56614e-18	1	1	0
PPM1B	5495	broad.mit.edu	37	2	44457623	44457623	+	Missense_Mutation	SNP	T	T	G			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	14591343-b381-43d0-aea0-0e02221c09c6	g.chr2:44457623T>G	ENST00000282412.4	+	6	1618	c.1206T>G	c.(1204-1206)aaT>aaG	p.N402K	PPM1B_ENST00000378551.2_Intron|PPM1B_ENST00000378540.4_Intron|PPM1B_ENST00000409432.3_3'UTR|PPM1B_ENST00000345249.4_Missense_Mutation_p.N115K	NM_002706.4	NP_002697.1	O75688	PPM1B_HUMAN	protein phosphatase, Mg2+/Mn2+ dependent, 1B	402					protein dephosphorylation	protein serine/threonine phosphatase complex	magnesium ion binding|manganese ion binding|protein binding|protein serine/threonine phosphatase activity			kidney(4)|large_intestine(3)|lung(7)|skin(2)	16		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)				TGAGAATTAATCATAGGGGAA	0.473000													21	67					0	0	1	0	0
RPLP0P2	113157	broad.mit.edu	37	11	61404307	61404307	+	RNA	SNP	G	G	T			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	14591343-b381-43d0-aea0-0e02221c09c6	g.chr11:61404307G>T	ENST00000496593.1	+	0	911					NR_002775.2																						GCAAGGCCGTGGTGCTGATGG	0.552000													16	46					3.45872e-05	3.70875e-05	1	1	0
PCYOX1	51449	broad.mit.edu	37	2	70502098	70502098	+	Missense_Mutation	SNP	C	C	T			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	14591343-b381-43d0-aea0-0e02221c09c6	g.chr2:70502098C>T	ENST00000433351.2	+	4	530	c.502C>T	c.(502-504)Cgc>Tgc	p.R168C	PCYOX1_ENST00000264441.5_Missense_Mutation_p.R168C|PCYOX1_ENST00000545138.1_Missense_Mutation_p.R90C|PCYOX1_ENST00000505044.2_Missense_Mutation_p.R91C	NM_016297.3	NP_057381.3	Q9UHG3	PCYOX_HUMAN	prenylcysteine oxidase 1	168					prenylated protein catabolic process	lysosome|very-low-density lipoprotein particle	prenylcysteine oxidase activity			breast(1)|central_nervous_system(3)|endometrium(1)|kidney(1)|large_intestine(3)|lung(6)	15						AAGGATCTACCGCTACCAGTC	0.408000													7	221					0	0	1	0	0
GRID1	2894	broad.mit.edu	37	10	87966299	87966299	+	Silent	SNP	G	G	C			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	14591343-b381-43d0-aea0-0e02221c09c6	g.chr10:87966299G>C	ENST00000327946.7	-	3	427	c.342C>G	c.(340-342)ctC>ctG	p.L114L		NM_017551.2	NP_060021.1	Q9ULK0	GRID1_HUMAN	glutamate receptor, ionotropic, delta 1	114						cell junction|integral to membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(24)|lung(46)|ovary(5)|prostate(4)|skin(5)|stomach(4)|upper_aerodigestive_tract(5)	106					L-Glutamic Acid(DB00142)	GCTGGACAAAGAGGTGTGGGA	0.632000										Multiple Myeloma(13;0.14)			50	117					0	0	1	0	0
DNAJB12	54788	broad.mit.edu	37	10	74100574	74100574	+	Silent	SNP	C	C	T			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	14591343-b381-43d0-aea0-0e02221c09c6	g.chr10:74100574C>T	ENST00000338820.3	-	5	947	c.798G>A	c.(796-798)agG>agA	p.R266R	DNAJB12_ENST00000461919.1_5'UTR|DNAJB12_ENST00000394903.2_Silent_p.R266R|DNAJB12_ENST00000444643.2_Silent_p.R232R	NM_001002762.2	NP_001002762.2	Q9NXW2	DJB12_HUMAN	DnaJ (Hsp40) homolog, subfamily B, member 12	232					protein folding	endoplasmic reticulum|integral to membrane	heat shock protein binding|unfolded protein binding			endometrium(1)|large_intestine(2)|skin(1)	4						TGCGGTCCTGCCTTTGCTGGT	0.642000													15	28					0	0	1	0	0
TRIM33	51592	broad.mit.edu	37	1	114967253	114967253	+	Missense_Mutation	SNP	C	C	A			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	14591343-b381-43d0-aea0-0e02221c09c6	g.chr1:114967253C>A	ENST00000358465.2	-	10	1903	c.1820G>T	c.(1819-1821)gGc>gTc	p.G607V	TRIM33_ENST00000450349.2_Missense_Mutation_p.G215V|TRIM33_ENST00000369543.2_Missense_Mutation_p.G607V	NM_015906.3	NP_056990.3	Q9UPN9	TRI33_HUMAN	tripartite motif containing 33	607					negative regulation of BMP signaling pathway|negative regulation of transcription, DNA-dependent|protein ubiquitination|regulation of transforming growth factor beta receptor signaling pathway|transcription, DNA-dependent	nucleus	co-SMAD binding|DNA binding|ligase activity|R-SMAD binding|zinc ion binding			breast(2)|central_nervous_system(5)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(10)|lung(14)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	48	all_epithelial(7;0.000132)|all_lung(7;0.00106)|Lung SC(450;0.184)	all_cancers(81;3.03e-08)|all_epithelial(167;3.24e-08)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		ATATTGAGGGCCGCTGTGCCT	0.433000			T	RET	papillary thyroid								61	130					9.12251e-31	1.05442e-30	1	1	0
SLIT2	9353	broad.mit.edu	37	4	20599967	20599967	+	Missense_Mutation	SNP	G	G	A			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	14591343-b381-43d0-aea0-0e02221c09c6	g.chr4:20599967G>A	ENST00000504154.1	+	33	3893	c.3641G>A	c.(3640-3642)cGt>cAt	p.R1214H	SLIT2_ENST00000503837.1_Missense_Mutation_p.R1210H|SLIT2_ENST00000503823.1_Missense_Mutation_p.R1206H|SLIT2_ENST00000273739.5_Missense_Mutation_p.R1227H	NM_004787.1	NP_004778.1	O94813	SLIT2_HUMAN	slit homolog 2 (Drosophila)	1214	Laminin G-like.				apoptosis involved in luteolysis|axon extension involved in axon guidance|branching morphogenesis of a tube|cell migration involved in sprouting angiogenesis|cellular response to heparin|cellular response to hormone stimulus|chemorepulsion involved in postnatal olfactory bulb interneuron migration|corticospinal neuron axon guidance through spinal cord|induction of negative chemotaxis|motor axon guidance|negative regulation of actin filament polymerization|negative regulation of cell growth|negative regulation of cellular response to growth factor stimulus|negative regulation of chemokine-mediated signaling pathway|negative regulation of endothelial cell migration|negative regulation of lamellipodium assembly|negative regulation of mononuclear cell migration|negative regulation of neutrophil chemotaxis|negative regulation of protein phosphorylation|negative regulation of retinal ganglion cell axon guidance|negative regulation of small GTPase mediated signal transduction|negative regulation of smooth muscle cell chemotaxis|negative regulation of vascular permeability|positive regulation of apoptosis|positive regulation of axonogenesis|response to cortisol stimulus|retinal ganglion cell axon guidance|Roundabout signaling pathway|ureteric bud development	cell surface|cytoplasm|extracellular space|plasma membrane	calcium ion binding|GTPase inhibitor activity|heparin binding|laminin-1 binding|protein homodimerization activity|proteoglycan binding|Roundabout binding			NS(1)|breast(4)|central_nervous_system(4)|cervix(1)|endometrium(5)|kidney(7)|large_intestine(17)|lung(60)|ovary(3)|pancreas(1)|prostate(2)|skin(10)|upper_aerodigestive_tract(1)	116						TATCGGGGGCGTGTTCGTGCC	0.473000													82	113					0	0	1	0	0
LDLR	3949	broad.mit.edu	37	19	11224382	11224382	+	Silent	SNP	G	G	A			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	14591343-b381-43d0-aea0-0e02221c09c6	g.chr19:11224382G>A	ENST00000558518.1	+	10	1717	c.1530G>A	c.(1528-1530)acG>acA	p.T510T	LDLR_ENST00000455727.2_Silent_p.T342T|LDLR_ENST00000558013.1_Silent_p.T510T|LDLR_ENST00000535915.1_Silent_p.T469T|LDLR_ENST00000557933.1_Silent_p.T510T|LDLR_ENST00000545707.1_Silent_p.T383T	NM_000527.4|NM_001195798.1	NP_000518.1|NP_001182727.1	P01130	LDLR_HUMAN	low density lipoprotein receptor	510					cholesterol homeostasis|cholesterol metabolic process|interspecies interaction between organisms|intestinal cholesterol absorption|low-density lipoprotein particle clearance|receptor-mediated endocytosis	clathrin-coated endocytic vesicle membrane|coated pit|early endosome|endosome membrane|external side of plasma membrane|integral to plasma membrane|low-density lipoprotein particle|lysosome	calcium ion binding|low-density lipoprotein receptor activity|protein binding|very-low-density lipoprotein particle receptor activity	p.?(1)		breast(2)|endometrium(2)|large_intestine(5)|lung(8)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	26		Lung NSC(9;0.000245)|Renal(1328;0.0007)|Hepatocellular(1079;0.0524)		GBM - Glioblastoma multiforme(1328;1.36e-05)|STAD - Stomach adenocarcinoma(1328;0.000766)|Lung(535;0.197)	Methyl aminolevulinate(DB00992)|Porfimer(DB00707)	AGAGGAAAACGTTATTCAGGG	0.582000													19	47					0	0	1	0	0
CYTH1	9267	broad.mit.edu	37	17	76692093	76692093	+	Splice_Site	SNP	T	T	A			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	14591343-b381-43d0-aea0-0e02221c09c6	g.chr17:76692093T>A	ENST00000589297.1	-	10	1327		c.e10-2		CYTH1_ENST00000585509.1_Splice_Site|CYTH1_ENST00000446868.3_Splice_Site|CYTH1_ENST00000591455.1_Intron|CYTH1_ENST00000361101.4_Intron|CYTH1_ENST00000589296.1_Intron			Q15438	CYH1_HUMAN	cytohesin 1						regulation of ARF protein signal transduction|regulation of cell adhesion|vesicle-mediated transport	cytoplasm|plasma membrane	ARF guanyl-nucleotide exchange factor activity|protein binding			endometrium(4)|kidney(1)|large_intestine(2)|lung(7)|ovary(1)|skin(2)|upper_aerodigestive_tract(2)	19						ACATACCTCCTGGAGTTTGGG	0.388000													42	84					0	0	1	0	0
AEBP2	121536	broad.mit.edu	37	12	19646732	19646732	+	Splice_Site	SNP	A	A	T			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	14591343-b381-43d0-aea0-0e02221c09c6	g.chr12:19646732A>T	ENST00000266508.9	+	4	988		c.e4-1		AEBP2_ENST00000360995.4_Splice_Site|AEBP2_ENST00000541908.1_Splice_Site|AEBP2_ENST00000398864.3_Splice_Site	NM_153207.4	NP_694939.2	Q6ZN18	AEBP2_HUMAN	AE binding protein 2						chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	ESC/E(Z) complex	DNA binding|zinc ion binding			ovary(1)	1	Acute lymphoblastic leukemia(4;0.000455)|all_hematologic(4;0.00804)|Esophageal squamous(101;0.143)					ATTTTCTTTTAGTGTGTTGTT	0.418000													8	61					0	0	1	0	0
RHOBTB1	9886	broad.mit.edu	37	10	62670706	62670706	+	Missense_Mutation	SNP	A	A	T			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	14591343-b381-43d0-aea0-0e02221c09c6	g.chr10:62670706A>T	ENST00000337910.5	-	4	572	c.235T>A	c.(235-237)Tct>Act	p.S79T	RHOBTB1_ENST00000357917.4_Missense_Mutation_p.S79T	NM_001242359.1|NM_014836.4	NP_001229288.1|NP_055651.1	O94844	RHBT1_HUMAN	Rho-related BTB domain containing 1	79	Rho-like.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|plasma membrane	GTP binding			endometrium(4)|large_intestine(6)|lung(11)|ovary(1)|upper_aerodigestive_tract(1)	23	Prostate(12;0.0112)					AGCCTGAGAGAAACACTCACT	0.488000													40	104					0	0	1	0	0
WDR46	9277	broad.mit.edu	37	6	33254931	33254931	+	Missense_Mutation	SNP	C	C	T			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	14591343-b381-43d0-aea0-0e02221c09c6	g.chr6:33254931C>T	ENST00000374617.4	-	9	1308	c.952G>A	c.(952-954)Ggg>Agg	p.G318R		NM_001164267.1|NM_005452.5	NP_001157739.1|NP_005443.3	O15213	WDR46_HUMAN	WD repeat domain 46	318										NS(1)|breast(2)|kidney(1)|large_intestine(6)|lung(9)|prostate(1)	20						TCGAGCCGCCCAGCTCGAGCA	0.502000													56	150					0	0	1	0	0
SHROOM2	357	broad.mit.edu	37	X	9914789	9914789	+	Missense_Mutation	SNP	C	C	T			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	14591343-b381-43d0-aea0-0e02221c09c6	g.chrX:9914789C>T	ENST00000380913.3	+	10	4753	c.4663C>T	c.(4663-4665)Cgc>Tgc	p.R1555C	SHROOM2_ENST00000418909.2_Missense_Mutation_p.R390C	NM_001649.2	NP_001640.1	Q13796	SHRM2_HUMAN	shroom family member 2	1555	ASD2.				apical protein localization|brain development|cell migration|cell morphogenesis|cellular pigment accumulation|ear development|establishment of melanosome localization|eye pigment granule organization|lens morphogenesis in camera-type eye|melanosome organization	apical plasma membrane|cell-cell adherens junction|microtubule|tight junction	actin filament binding|beta-catenin binding|ligand-gated sodium channel activity	p.R1555C(1)		breast(4)|central_nervous_system(2)|cervix(3)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(13)|ovary(3)|prostate(3)|skin(6)|upper_aerodigestive_tract(2)	57		Hepatocellular(5;0.000888)				CCTGGACCGCCGCGAGCGCAT	0.547000													8	18					0	0	1	0	0
CSTF3	1479	broad.mit.edu	37	11	33123767	33123767	+	Missense_Mutation	SNP	C	C	T			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	14591343-b381-43d0-aea0-0e02221c09c6	g.chr11:33123767C>T	ENST00000323959.4	-	10	921	c.782G>A	c.(781-783)aGc>aAc	p.S261N	TCP11L1_ENST00000324357.9_Intron	NM_001326.2	NP_001317.1	Q12996	CSTF3_HUMAN	cleavage stimulation factor, 3' pre-RNA, subunit 3, 77kDa	261					mRNA cleavage|mRNA polyadenylation|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	nucleoplasm	protein binding|RNA binding			breast(2)|endometrium(4)|kidney(1)|large_intestine(5)|lung(4)|prostate(1)|skin(1)|stomach(1)	19						AAGAGGGTTGCTCTTTTCCCA	0.433000													27	104					0	0	1	0	0
WDR66	144406	broad.mit.edu	37	12	122369710	122369710	+	Missense_Mutation	SNP	A	A	T			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	14591343-b381-43d0-aea0-0e02221c09c6	g.chr12:122369710A>T	ENST00000288912.4	+	4	1660	c.806A>T	c.(805-807)gAa>gTa	p.E269V	WDR66_ENST00000397454.2_Missense_Mutation_p.E269V	NM_144668.5	NP_653269.3	Q8TBY9	WDR66_HUMAN	WD repeat domain 66	269							calcium ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(11)|liver(2)|lung(13)|ovary(2)|prostate(2)|skin(2)|soft_tissue(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	43	all_neural(191;0.0496)|Medulloblastoma(191;0.0922)			OV - Ovarian serous cystadenocarcinoma(86;0.000155)|Epithelial(86;0.000634)|BRCA - Breast invasive adenocarcinoma(302;0.248)		ATTCGAGAGGAAAGGCAGAGA	0.453000													45	108					0	0	1	0	0
TMEM214	54867	broad.mit.edu	37	2	27256957	27256957	+	Silent	SNP	C	C	A			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	14591343-b381-43d0-aea0-0e02221c09c6	g.chr2:27256957C>A	ENST00000238788.9	+	2	236	c.174C>A	c.(172-174)acC>acA	p.T58T	TMEM214_ENST00000404032.3_Silent_p.T58T	NM_017727.4	NP_060197.4	Q6NUQ4	TM214_HUMAN	transmembrane protein 214	58						integral to membrane	protein binding			kidney(1)|large_intestine(5)|lung(9)|prostate(1)|skin(2)	18						CCACAAGCACCCTTTATGAGC	0.547000													91	160					7.22319e-40	8.45874e-40	1	1	0
CTPS1	1503	broad.mit.edu	37	1	41471734	41471734	+	Missense_Mutation	SNP	A	A	G			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	14591343-b381-43d0-aea0-0e02221c09c6	g.chr1:41471734A>G	ENST00000372621.4	+	13	1772	c.1264A>G	c.(1264-1266)Aca>Gca	p.T422A	CTPS1_ENST00000541520.1_Missense_Mutation_p.T191A|CTPS1_ENST00000372616.1_Missense_Mutation_p.T422A	NM_001905.2	NP_001896.2	P17812	PYRG1_HUMAN	CTP synthase 1	422	Glutamine amidotransferase type-1.				CTP biosynthetic process|glutamine metabolic process|nucleobase, nucleoside and nucleotide interconversion|response to drug	cytosol	ATP binding|CTP synthase activity|protein binding			endometrium(3)|lung(10)	13					L-Glutamine(DB00130)	TGCCAATTCTACAGAGTTTGA	0.408000													37	117					0	0	1	0	0
POM121C	100101267	broad.mit.edu	37	7	75054987	75054987	+	Missense_Mutation	SNP	C	C	G			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	14591343-b381-43d0-aea0-0e02221c09c6	g.chr7:75054987C>G	ENST00000453279.2	-	9	1441	c.577G>C	c.(577-579)Gaa>Caa	p.E193Q	POM121C_ENST00000257665.5_Missense_Mutation_p.E435Q|POM121C_ENST00000473168.1_5'UTR	NM_001099415.1	NP_001092885.1	A8CG34	P121C_HUMAN	POM121 transmembrane nucleoporin C	435	Pore side (Potential).|Required for targeting to the nucleus and nuclear pore complex.				mRNA transport|protein transport|transmembrane transport	endoplasmic reticulum membrane|nuclear membrane|nuclear pore	protein binding			central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(6)|prostate(1)|skin(1)|urinary_tract(1)	14						CACAGCTCTTCTTCTCTGTTG	0.453000													11	21					0	0	1	0	0
FCAR	2204	broad.mit.edu	37	19	55399613	55399613	+	Missense_Mutation	SNP	C	C	T			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	14591343-b381-43d0-aea0-0e02221c09c6	g.chr19:55399613C>T	ENST00000355524.3	+	4	611	c.601C>T	c.(601-603)Ccc>Tcc	p.P201S	FCAR_ENST00000359272.4_Missense_Mutation_p.P189S|FCAR_ENST00000469767.1_Missense_Mutation_p.P201S|FCAR_ENST00000391724.3_Intron|FCAR_ENST00000391723.3_Intron|FCAR_ENST00000391725.3_Intron|FCAR_ENST00000391726.3_Intron|FCAR_ENST00000345937.4_Intron|FCAR_ENST00000353758.4_Missense_Mutation_p.P92S|FCAR_ENST00000482092.2_Intron	NM_002000.2	NP_001991.1	P24071	FCAR_HUMAN	Fc fragment of IgA, receptor for	201					immune response	extracellular region|integral to plasma membrane	IgA binding|receptor activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(14)|ovary(1)|skin(2)	24				GBM - Glioblastoma multiforme(193;0.0443)		CAACAGGAGCCCCTACCTGTG	0.582000													8	27					0	0	1	0	0
ESPNP	284729	broad.mit.edu	37	1	17023321	17023321	+	RNA	SNP	T	T	G			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	14591343-b381-43d0-aea0-0e02221c09c6	g.chr1:17023321T>G	ENST00000492551.1	-	0	1626					NR_026567.1																						GTCAGCCCCTTGCTCTGTGGC	0.637000													4	57					0	0	1	0	0
VHL	7428	broad.mit.edu	37	3	10191488	10191488	+	Nonsense_Mutation	SNP	C	C	T	rs5030818		TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	14591343-b381-43d0-aea0-0e02221c09c6	g.chr3:10191488C>T	ENST00000256474.2	+	3	1321	c.481C>T	c.(481-483)Cga>Tga	p.R161*	VHL_ENST00000345392.2_Nonsense_Mutation_p.R120*|VHL_ENST00000477538.1_3'UTR	NM_000551.3	NP_000542.1	P40337	VHL_HUMAN	von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase	161	Interaction with Elongin BC complex.		R -> G (in VHLD; type II; dbSNP:rs5030818).|R -> P (in pheochromocytoma and VHLD; type I).|R -> Q (in pheochromocytoma and VHLD; type II).		anti-apoptosis|cell morphogenesis|negative regulation of cell proliferation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of cell differentiation|positive regulation of transcription, DNA-dependent|protein stabilization|protein ubiquitination|proteolysis	cytosol|endoplasmic reticulum|membrane|mitochondrion|nucleus	protein binding|transcription factor binding	p.R161*(13)|p.E160fs*9(2)|p.R161del(1)|p.R161fs*13(1)|p.?fs(1)|p.L158fs*6(1)|p.E160fs*13(1)|p.R161fs*9(1)		adrenal_gland(25)|autonomic_ganglia(3)|central_nervous_system(2)|endometrium(6)|kidney(1662)|large_intestine(14)|lung(6)|pancreas(18)|paratesticular_tissues(1)|pleura(1)|skin(1)|soft_tissue(24)|thyroid(3)|upper_aerodigestive_tract(3)	1769				Kidney(1;0.000404)|KIRC - Kidney renal clear cell carcinoma(1;0.000569)		TCTGAAAGAGCGATGCCTCCA	0.502000		1	"""D, Mis, N, F, S"""		"""renal, hemangioma, pheochromocytoma"""	"""renal, hemangioma, pheochromocytoma"""			von Hippel-Lindau disease;Pheochromocytoma (Adrenal), Familial;Chuvash Polycythemia				18	38					0	0	1	0	0
TUBB8P7	197331	broad.mit.edu	37	16	90161902	90161902	+	RNA	SNP	A	A	G	rs6500471	by1000genomes	TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	14591343-b381-43d0-aea0-0e02221c09c6	g.chr16:90161902A>G	ENST00000567960.1	+	0	638				TUBB8P7_ENST00000564451.1_RNA														p.K213R(8)									ATATGTTCCAAGACCCTAAAA	0.537000													4	88					0	0	1	0	0
WDR83	84292	broad.mit.edu	37	19	12783897	12783897	+	Missense_Mutation	SNP	T	T	A			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	14591343-b381-43d0-aea0-0e02221c09c6	g.chr19:12783897T>A	ENST00000418543.3	+	9	999	c.650T>A	c.(649-651)cTc>cAc	p.L217H	WDR83_ENST00000242796.4_Missense_Mutation_p.L217H	NM_001099737.2	NP_001093207.1	Q9BRX9	WDR83_HUMAN	WD repeat domain 83	217					nuclear mRNA splicing, via spliceosome	catalytic step 2 spliceosome|cytoplasm				breast(2)|large_intestine(1)|lung(1)	4						ACATTGCGGCTCCTGGACAAA	0.657000													42	86					0	0	1	0	0
SETD2	29072	broad.mit.edu	37	3	47162162	47162162	+	Nonsense_Mutation	SNP	G	G	A			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	14591343-b381-43d0-aea0-0e02221c09c6	g.chr3:47162162G>A	ENST00000409792.3	-	3	4006	c.3964C>T	c.(3964-3966)Cga>Tga	p.R1322*		NM_014159.6	NP_054878.5	Q9BYW2	SETD2_HUMAN	SET domain containing 2	1322					regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	DNA binding|histone-lysine N-methyltransferase activity|oxidoreductase activity|transition metal ion binding	p.R819*(2)|p.R1322*(2)		breast(6)|central_nervous_system(5)|endometrium(4)|kidney(63)|large_intestine(18)|lung(26)|ovary(6)|prostate(2)|skin(3)|soft_tissue(1)|stomach(2)|urinary_tract(5)	141		Acute lymphoblastic leukemia(5;0.0169)		BRCA - Breast invasive adenocarcinoma(193;0.000302)|KIRC - Kidney renal clear cell carcinoma(197;0.00732)|Kidney(197;0.00844)		CCTTGAGTTCGATCATACACA	0.463000			"""N, F, S, Mis"""		clear cell renal carcinoma								57	106					0	0	1	0	0
MAEA	10296	broad.mit.edu	37	4	1305934	1305934	+	Silent	SNP	C	C	T			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	14591343-b381-43d0-aea0-0e02221c09c6	g.chr4:1305934C>T	ENST00000303400.4	+	2	300	c.237C>T	c.(235-237)agC>agT	p.S79S	MAEA_ENST00000264750.6_Silent_p.S79S|MAEA_ENST00000510794.1_Silent_p.S78S|MAEA_ENST00000505177.2_Silent_p.S79S|MAEA_ENST00000505839.1_Silent_p.S31S|MAEA_ENST00000514708.1_Silent_p.S79S|MAEA_ENST00000452175.2_Silent_p.S68S	NM_001017405.1	NP_001017405.1	Q7L5Y9	MAEA_HUMAN	macrophage erythroblast attacher	79	Extracellular and involved in cell to cell contact.				cell adhesion|cell cycle|cell division|erythrocyte maturation|negative regulation of myeloid cell apoptosis|regulation of mitotic cell cycle	actomyosin contractile ring|integral to plasma membrane|membrane fraction|nuclear matrix|spindle	actin binding			NS(2)|central_nervous_system(1)|endometrium(2)|large_intestine(5)|lung(2)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	18			OV - Ovarian serous cystadenocarcinoma(23;0.0201)			AGAAGCTCAGCGTCCTCAAGA	0.622000													15	28					0	0	1	0	0
TSHZ2	128553	broad.mit.edu	37	20	51870416	51870416	+	Missense_Mutation	SNP	G	G	A			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	14591343-b381-43d0-aea0-0e02221c09c6	g.chr20:51870416G>A	ENST00000371497.5	+	2	1306	c.419G>A	c.(418-420)gGc>gAc	p.G140D	TSHZ2_ENST00000329613.6_Missense_Mutation_p.G137D|TSHZ2_ENST00000603338.2_Missense_Mutation_p.G137D	NM_001193421.1|NM_173485.5	NP_001180350.1|NP_775756.3	Q9NRE2	TSH2_HUMAN	teashirt zinc finger homeobox 2	140					multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(2)|breast(4)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(16)|lung(38)|ovary(5)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	84			STAD - Stomach adenocarcinoma(23;0.1)			TACTGGTCAGGCCTGGGCCTT	0.512000													14	220					0	0	1	0	0
TRIM3	10612	broad.mit.edu	37	11	6479378	6479378	+	Missense_Mutation	SNP	C	C	T			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	14591343-b381-43d0-aea0-0e02221c09c6	g.chr11:6479378C>T	ENST00000525074.1	-	3	674	c.280G>A	c.(280-282)Gat>Aat	p.D94N	TRIM3_ENST00000345851.3_Missense_Mutation_p.D94N|TRIM3_ENST00000359518.3_Missense_Mutation_p.D94N|TRIM3_ENST00000537602.1_Missense_Mutation_p.D94N|TRIM3_ENST00000536344.1_5'UTR	NM_001248006.1	NP_001234935.1	O75382	TRIM3_HUMAN	tripartite motif containing 3	94					nervous system development|protein transport	early endosome	protein C-terminus binding|zinc ion binding			breast(1)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(8)|ovary(1)|prostate(2)|skin(3)	27		all_lung(207;9.97e-06)|Lung NSC(207;1.74e-05)|Medulloblastoma(188;0.00225)|Breast(177;0.0204)|all_neural(188;0.0212)		Epithelial(150;9.34e-10)|Lung(200;0.0234)|LUSC - Lung squamous cell carcinoma(625;0.133)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TGGGCCCCATCAGGTGCCTGC	0.647000													53	112					0	0	1	0	0
SUCO	51430	broad.mit.edu	37	1	172547460	172547460	+	Nonsense_Mutation	SNP	G	G	T			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	14591343-b381-43d0-aea0-0e02221c09c6	g.chr1:172547460G>T	ENST00000367723.3	+	13	1943	c.1819G>T	c.(1819-1821)Gaa>Taa	p.E607*	SUCO_ENST00000263688.3_Nonsense_Mutation_p.E455*	NM_016227.2	NP_057311.2			SUN domain containing ossification factor																		TAGCATGGTGGAAGAATATGA	0.368000													4	59					1	1	1	1	0
STYK1	55359	broad.mit.edu	37	12	10783738	10783738	+	Silent	SNP	C	C	T			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	14591343-b381-43d0-aea0-0e02221c09c6	g.chr12:10783738C>T	ENST00000075503.3	-	5	877	c.357G>A	c.(355-357)caG>caA	p.Q119Q		NM_018423.2	NP_060893.2	Q6J9G0	STYK1_HUMAN	serine/threonine/tyrosine kinase 1	119	Protein kinase.					integral to membrane|plasma membrane	ATP binding|non-membrane spanning protein tyrosine kinase activity			breast(1)|central_nervous_system(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(1)|liver(1)|lung(8)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)	26						CACTGCAAATCTGCTCCAGAA	0.507000										HNSCC(73;0.22)			9	131					0	0	1	0	0
RBM43	375287	broad.mit.edu	37	2	152112099	152112099	+	Missense_Mutation	SNP	T	T	C			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	14591343-b381-43d0-aea0-0e02221c09c6	g.chr2:152112099T>C	ENST00000331426.5	-	2	313	c.162A>G	c.(160-162)atA>atG	p.I54M		NM_198557.2	NP_940959.1	Q6ZSC3	RBM43_HUMAN	RNA binding motif protein 43	54	RRM.						nucleotide binding|RNA binding			endometrium(2)|large_intestine(3)|lung(2)|ovary(1)	8				BRCA - Breast invasive adenocarcinoma(221;0.131)		TTGTCGGATATATCACATCTT	0.338000													59	132					0	0	1	0	0
SIPA1L3	23094	broad.mit.edu	37	19	38573642	38573642	+	Silent	SNP	C	C	T			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	14591343-b381-43d0-aea0-0e02221c09c6	g.chr19:38573642C>T	ENST00000222345.6	+	3	1946	c.1437C>T	c.(1435-1437)ccC>ccT	p.P479P		NM_015073.1	NP_055888.1	O60292	SI1L3_HUMAN	signal-induced proliferation-associated 1 like 3	479					regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			NS(1)|breast(3)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(8)|lung(22)|ovary(2)|prostate(4)|skin(3)	59			Lung(45;0.000246)|LUSC - Lung squamous cell carcinoma(53;0.000292)			TGGAAGTTCCCAAGGAGCAGC	0.672000													10	26					0	0	1	0	0
EEF1B2	1933	broad.mit.edu	37	2	207025358	207025358	+	Missense_Mutation	SNP	A	A	G			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	14591343-b381-43d0-aea0-0e02221c09c6	g.chr2:207025358A>G	ENST00000392222.2	+	2	502	c.127A>G	c.(127-129)Agc>Ggc	p.S43G	EEF1B2_ENST00000392221.1_Missense_Mutation_p.S43G|EEF1B2_ENST00000236957.5_Missense_Mutation_p.S43G	NM_001959.3	NP_001950.1	P24534	EF1B_HUMAN	eukaryotic translation elongation factor 1 beta 2	43	GST C-terminal.					cytosol|eukaryotic translation elongation factor 1 complex	protein binding|translation elongation factor activity	p.S43G(4)		breast(1)|endometrium(5)|kidney(3)|large_intestine(1)|lung(6)	16						AGCCGTGTCCAGCCCACCGCC	0.468000													4	70					0	0	1	0	0
GRPEL1	80273	broad.mit.edu	37	4	7062876	7062876	+	Nonsense_Mutation	SNP	G	G	A			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	14591343-b381-43d0-aea0-0e02221c09c6	g.chr4:7062876G>A	ENST00000264954.4	-	4	531	c.367C>T	c.(367-369)Cag>Tag	p.Q123*	GRPEL1_ENST00000514056.1_5'UTR	NM_025196.2	NP_079472.1	Q9HAV7	GRPE1_HUMAN	GrpE-like 1, mitochondrial (E. coli)	123					protein folding|protein import into mitochondrial matrix	mitochondrial matrix	adenyl-nucleotide exchange factor activity|chaperone binding|protein homodimerization activity|unfolded protein binding			endometrium(1)|kidney(1)|large_intestine(2)|lung(1)	5						GGAACACACTGTGTTGCCTTC	0.463000													47	139					0	0	1	0	0
ASCC3	10973	broad.mit.edu	37	6	101095127	101095127	+	Silent	SNP	C	C	A			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	14591343-b381-43d0-aea0-0e02221c09c6	g.chr6:101095127C>A	ENST00000369162.2	-	21	3797	c.3453G>T	c.(3451-3453)ctG>ctT	p.L1151L		NM_006828.2	NP_006819.2	Q8N3C0	HELC1_HUMAN	activating signal cointegrator 1 complex subunit 3	1151	SEC63 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|microtubule cytoskeleton	ATP binding|ATP-dependent helicase activity|nucleic acid binding			breast(4)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(20)|liver(1)|lung(36)|ovary(6)|prostate(4)|skin(3)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	92		all_cancers(76;1.45e-07)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(87;0.00149)|Hepatocellular(1;0.0893)|Colorectal(196;0.13)		BRCA - Breast invasive adenocarcinoma(108;0.0539)|all cancers(137;0.103)|GBM - Glioblastoma multiforme(226;0.199)		TCATGTCTTTCAGCTTATCCA	0.368000													8	72					1.12685e-05	1.22305e-05	1	1	0
COL11A2	1302	broad.mit.edu	37	6	33140387	33140387	+	Missense_Mutation	SNP	C	C	A			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	14591343-b381-43d0-aea0-0e02221c09c6	g.chr6:33140387C>A	ENST00000341947.2	-	39	3045	c.2818G>T	c.(2818-2820)Ggg>Tgg	p.G940W	COL11A2_ENST00000395197.1_Missense_Mutation_p.G880W|COL11A2_ENST00000374713.1_Missense_Mutation_p.G893W|COL11A2_ENST00000477772.1_Intron|COL11A2_ENST00000357486.1_Missense_Mutation_p.G919W|COL11A2_ENST00000374712.1_Missense_Mutation_p.G859W|COL11A2_ENST00000361917.1_Missense_Mutation_p.G833W|COL11A2_ENST00000374714.1_Missense_Mutation_p.G914W|COL11A2_ENST00000374708.4_Missense_Mutation_p.G854W	NM_080680.2	NP_542411.2	P13942	COBA2_HUMAN	collagen, type XI, alpha 2	940	Triple-helical region.		Missing (in STL3).		cartilage development|cell adhesion|collagen fibril organization|sensory perception of sound|soft palate development	collagen type XI	extracellular matrix structural constituent conferring tensile strength|protein binding, bridging			biliary_tract(1)|breast(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|liver(1)|lung(27)|ovary(5)|prostate(5)|skin(6)	68						CCTCTCTCCCCCATAGGGCCG	0.627000													19	38					1.36565e-18	1.55824e-18	1	1	0
ITPR2	3709	broad.mit.edu	37	12	26848561	26848561	+	Missense_Mutation	SNP	G	G	C			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	14591343-b381-43d0-aea0-0e02221c09c6	g.chr12:26848561G>C	ENST00000381340.3	-	10	1390	c.974C>G	c.(973-975)gCc>gGc	p.A325G		NM_002223.2	NP_002214.2	Q14571	ITPR2_HUMAN	inositol 1,4,5-trisphosphate receptor, type 2	325	MIR 4.				activation of phospholipase C activity|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	integral to membrane|plasma membrane enriched fraction|platelet dense tubular network membrane|sarcoplasmic reticulum membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity		ETV6/ITPR2(2)	biliary_tract(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(16)|large_intestine(20)|liver(1)|lung(51)|ovary(5)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(5)|urinary_tract(3)	125	Colorectal(261;0.0847)					TTCATTTTGGGCATCTCGATA	0.303000													18	86					0	0	1	0	0
LUZP1	7798	broad.mit.edu	37	1	23417944	23417945	+	Frame_Shift_Ins	INS	-	-	G			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr1:23417944_23417945insG	ENST00000302291.4	-	4	3611_3612	c.2810_2811insC	c.(2809-2811)cacfs	p.H937fs	LUZP1_ENST00000374623.3_Frame_Shift_Ins_p.H937fs|LUZP1_ENST00000314174.5_Frame_Shift_Ins_p.H937fs|LUZP1_ENST00000418342.1_Frame_Shift_Ins_p.H937fs			Q86V48	LUZP1_HUMAN	leucine zipper protein 1	937						nucleus				NS(1)|breast(1)|endometrium(6)|kidney(1)|large_intestine(8)|lung(12)|upper_aerodigestive_tract(2)	31		Colorectal(325;3.46e-05)|Lung NSC(340;4.15e-05)|all_lung(284;6.64e-05)|Renal(390;0.000219)|Ovarian(437;0.00373)|Breast(348;0.00815)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;4.88e-27)|Colorectal(126;8.36e-08)|COAD - Colon adenocarcinoma(152;4.31e-06)|GBM - Glioblastoma multiforme(114;8.64e-05)|BRCA - Breast invasive adenocarcinoma(304;0.00112)|KIRC - Kidney renal clear cell carcinoma(1967;0.00176)|STAD - Stomach adenocarcinoma(196;0.0146)|READ - Rectum adenocarcinoma(331;0.0686)|Lung(427;0.0967)|LUSC - Lung squamous cell carcinoma(448;0.199)		CTATTCGAGTTGGGGGGTCTTC	0.495													14	764	---	---	---	---					
UBXN11	91544	broad.mit.edu	37	1	26608843	26608844	+	In_Frame_Ins	INS	-	-	GGGACA	rs6667693	by1000genomes	TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr1:26608843_26608844insGGGACA	ENST00000314675.7	-	11	1228_1229	c.1149_1150insTGTCCC	c.(1147-1152)ccgtcc>ccTGTCCCgtcc	p.382_383insPV	UBXN11_ENST00000357089.4_In_Frame_Ins_p.469_470insPV|UBXN11_ENST00000374217.2_In_Frame_Ins_p.469_470insPV|UBXN11_ENST00000374223.1_In_Frame_Ins_p.259_260insPV|UBXN11_ENST00000374222.1_In_Frame_Ins_p.502_503insPV|UBXN11_ENST00000374221.3_In_Frame_Ins_p.502_503insPV	NM_001077262.1	NP_001070730.1	Q5T124	UBX11_HUMAN	UBX domain protein 11	502						cytoplasm|cytoskeleton		p.P503_G504insCP(1)|p.G490_P515delGPGPSPGPGPGPSPGPGPGPSPCPGP(1)		endometrium(3)|kidney(2)|large_intestine(4)|lung(6)|ovary(2)|prostate(3)|upper_aerodigestive_tract(3)	23						ggaccgggaccgggactggggc	0.733													9	15	---	---	---	---					
KIAA1522	57648	broad.mit.edu	37	1	33233494	33233495	+	Frame_Shift_Ins	INS	-	-	C			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr1:33233494_33233495insC	ENST00000401073.2	+	2	412_413	c.342_343insC	c.(340-345)cgccccfs	p.RP114fs	KIAA1522_ENST00000294521.3_Frame_Shift_Ins_p.RP55fs|KIAA1522_ENST00000373481.3_Frame_Shift_Ins_p.RP66fs|KIAA1522_ENST00000373480.1_Frame_Shift_Ins_p.RP55fs	NM_020888.2	NP_065939.2	Q9P206	K1522_HUMAN	KIAA1522	55			S -> P (in dbSNP:rs3737994).							breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(2)|lung(5)|ovary(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	24		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Breast(348;0.244)				CCAGTGGGCGACCCCCCCACCT	0.614													7	265	---	---	---	---					
MAP7D1	55700	broad.mit.edu	37	1	36643780	36643781	+	Frame_Shift_Ins	INS	-	-	C			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr1:36643780_36643781insC	ENST00000316156.4	+	8	2028_2029	c.1575_1576insC	c.(1573-1578)caccccfs	p.HP525fs	MAP7D1_ENST00000373148.4_Frame_Shift_Ins_p.HP108fs|MAP7D1_ENST00000373150.4_Frame_Shift_Ins_p.HP530fs|MAP7D1_ENST00000373151.2_Frame_Shift_Ins_p.HP562fs			Q3KQU3	MA7D1_HUMAN	MAP7 domain containing 1	562	Pro-rich.					cytoplasm|spindle				breast(2)|cervix(1)|endometrium(2)|large_intestine(3)|lung(3)|ovary(3)|prostate(3)|skin(1)|urinary_tract(1)	19		Myeloproliferative disorder(586;0.0393)				AGAAGGAGCAGCCCCCCGCGGA	0.698													2	4	---	---	---	---					
CSF3R	1441	broad.mit.edu	37	1	36935322	36935323	+	Frame_Shift_Ins	INS	-	-	G			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr1:36935322_36935323insG	ENST00000373103.1	-	11	1951_1952	c.1404_1405insC	c.(1402-1407)ccgcgcfs	p.R469fs	CSF3R_ENST00000373104.1_Frame_Shift_Ins_p.R469fs|CSF3R_ENST00000373106.1_Frame_Shift_Ins_p.R469fs|CSF3R_ENST00000361632.4_Frame_Shift_Ins_p.R469fs|CSF3R_ENST00000338937.5_Frame_Shift_Ins_p.R469fs|CSF3R_ENST00000440588.2_Frame_Shift_Ins_p.R469fs|CSF3R_ENST00000487540.2_5'UTR|CSF3R_ENST00000418048.2_Frame_Shift_Ins_p.R469fs|CSF3R_ENST00000331941.5_Frame_Shift_Ins_p.R469fs	NM_156039.3	NP_724781.1	Q99062	CSF3R_HUMAN	colony stimulating factor 3 receptor (granulocyte)	469	Fibronectin type-III 4.				cell adhesion|defense response	extracellular region|integral to plasma membrane	cytokine receptor activity			central_nervous_system(3)|endometrium(2)|kidney(3)|large_intestine(9)|lung(16)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	38		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)			Filgrastim(DB00099)|Pegfilgrastim(DB00019)	TTGCTCGCGCTGGGGGGGCCCA	0.634													10	381	---	---	---	---					
HIVEP3	59269	broad.mit.edu	37	1	42049248	42049249	+	Frame_Shift_Ins	INS	-	-	G			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr1:42049248_42049249insG	ENST00000372584.1	-	3	2234_2235	c.1220_1221insC	c.(1219-1221)caafs	p.Q407fs	HIVEP3_ENST00000429157.2_Frame_Shift_Ins_p.Q407fs|HIVEP3_ENST00000372583.1_Frame_Shift_Ins_p.Q407fs|HIVEP3_ENST00000247584.5_Frame_Shift_Ins_p.Q407fs	NM_001127714.2	NP_001121186.1	Q5T1R4	ZEP3_HUMAN	human immunodeficiency virus type I enhancer binding protein 3	407	No DNA binding activity or transactivation activity, but complete prevention of TRAF-dependent NF-Kappa-B activation; associates with TRAF2 and JUN (By similarity).|Ser-rich.				positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			NS(2)|breast(3)|central_nervous_system(5)|endometrium(13)|kidney(3)|large_intestine(13)|lung(33)|ovary(4)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	85	Ovarian(52;0.00769)|all_hematologic(146;0.109)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0367)				CGTTGGTGTTTGGGGGGCTGAC	0.594													10	309	---	---	---	---					
HIVEP3	59269	broad.mit.edu	37	1	42050006	42050007	+	Frame_Shift_Ins	INS	-	-	G	rs138785392		TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr1:42050006_42050007insG	ENST00000372584.1	-	3	1476_1477	c.462_463insC	c.(460-465)ccaggafs	p.G155fs	HIVEP3_ENST00000429157.2_Frame_Shift_Ins_p.G155fs|HIVEP3_ENST00000372583.1_Frame_Shift_Ins_p.G155fs|HIVEP3_ENST00000247584.5_Frame_Shift_Ins_p.G155fs	NM_001127714.2	NP_001121186.1	Q5T1R4	ZEP3_HUMAN	human immunodeficiency virus type I enhancer binding protein 3	155					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			NS(2)|breast(3)|central_nervous_system(5)|endometrium(13)|kidney(3)|large_intestine(13)|lung(33)|ovary(4)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	85	Ovarian(52;0.00769)|all_hematologic(146;0.109)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0367)				GGAAGGTCCTCGGGGGGAATGA	0.604													9	529	---	---	---	---					
ZMYND12	84217	broad.mit.edu	37	1	42898878	42898879	+	Frame_Shift_Ins	INS	-	-	G			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr1:42898878_42898879insG	ENST00000372565.3	-	7	1179_1180	c.910_911insC	c.(910-912)aaafs	p.K304fs	ZMYND12_ENST00000475426.1_5'UTR|ZMYND12_ENST00000433602.2_Frame_Shift_Ins_p.K194fs	NM_032257.4	NP_115633.3	Q9H0C1	ZMY12_HUMAN	zinc finger, MYND-type containing 12	304						intracellular	zinc ion binding			NS(1)|endometrium(2)|large_intestine(3)|lung(5)|ovary(2)|prostate(2)|skin(2)	17	Ovarian(52;0.00744)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				GATGGTTTTTTGGGGGGCTTTG	0.411													9	490	---	---	---	---					
SLC2A1	6513	broad.mit.edu	37	1	43395453	43395454	+	Splice_Site	INS	-	-	G	rs113697235		TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr1:43395453_43395454insG	ENST00000426263.3	-	6	858		c.e6-2		SLC2A1_ENST00000415851.2_Intron|SLC2A1_ENST00000475162.1_Intron	NM_006516.2	NP_006507.2	P11166	GTR1_HUMAN	solute carrier family 2 (facilitated glucose transporter), member 1						carbohydrate metabolic process|energy reserve metabolic process|regulation of insulin secretion|water-soluble vitamin metabolic process	integral to membrane|melanosome|membrane fraction|midbody	D-glucose transmembrane transporter activity|dehydroascorbic acid transporter activity			autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|endometrium(2)|large_intestine(1)|lung(2)|ovary(1)|pancreas(2)	13	Ovarian(52;0.00579)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0122)			Etomidate(DB00292)	TCTTTAGCACTGGGGGGACCGG	0.629													9	670	---	---	---	---					
RNF220	55182	broad.mit.edu	37	1	44878032	44878033	+	Frame_Shift_Ins	INS	-	-	C			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr1:44878032_44878033insC	ENST00000355387.2	+	2	713_714	c.263_264insC	c.(262-264)tccfs	p.S88fs	RNF220_ENST00000372247.2_Frame_Shift_Ins_p.S88fs|RNF220_ENST00000361799.2_Frame_Shift_Ins_p.S88fs			Q5VTB9	RN220_HUMAN	ring finger protein 220	88					protein autoubiquitination	cytoplasm	ubiquitin-protein ligase activity|zinc ion binding			endometrium(6)|kidney(1)|large_intestine(3)|lung(13)|ovary(2)|skin(2)|urinary_tract(2)	29						AATCGTGATTTCCCCCCTTCTC	0.515													11	906	---	---	---	---					
FGGY	55277	broad.mit.edu	37	1	59812016	59812017	+	Frame_Shift_Ins	INS	-	-	G	rs145440779	by1000genomes	TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr1:59812016_59812017insG	ENST00000371218.4	+	4	595_596	c.411_412insG	c.(409-414)gtggggfs	p.VG137fs	FGGY_ENST00000474476.1_3'UTR|FGGY_ENST00000303721.7_Frame_Shift_Ins_p.VG137fs|FGGY_ENST00000371212.1_Intron	NM_001113411.1	NP_001106882.1	Q96C11	FGGY_HUMAN	FGGY carbohydrate kinase domain containing	137					carbohydrate metabolic process|cell death|neuron homeostasis		kinase activity|phosphotransferase activity, alcohol group as acceptor			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(13)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	22	all_cancers(7;7.36e-05)					TCCAGTACGTCGGGGGGGTGAT	0.500													22	264	---	---	---	---					
JAK1	3716	broad.mit.edu	37	1	65325832	65325833	+	Frame_Shift_Ins	INS	-	-	G			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr1:65325832_65325833insG	ENST00000342505.4	-	9	1537_1538	c.1289_1290insC	c.(1288-1290)cttfs	p.L430fs		NM_002227.2	NP_002218.2	P23458	JAK1_HUMAN	Janus kinase 1	430					interferon-gamma-mediated signaling pathway|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|response to antibiotic|type I interferon-mediated signaling pathway	cytoskeleton|cytosol|endomembrane system|membrane|nucleus	ATP binding|growth hormone receptor binding|non-membrane spanning protein tyrosine kinase activity			breast(5)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(48)|kidney(3)|large_intestine(8)|liver(2)|lung(19)|ovary(1)|prostate(12)|skin(1)|soft_tissue(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	120				BRCA - Breast invasive adenocarcinoma(111;0.0485)		GGACGATCAACGGGGGGGCCAC	0.540			Mis		ALL								10	308	---	---	---	---					
RPE65	6121	broad.mit.edu	37	1	68897205	68897206	+	Frame_Shift_Ins	INS	-	-	A			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr1:68897205_68897206insA	ENST00000262340.5	-	11	1244_1245	c.1191_1192insT	c.(1189-1194)agacgafs	p.RR397fs		NM_000329.2	NP_000320.1	Q16518	RPE65_HUMAN	retinal pigment epithelium-specific protein 65kDa	397					visual perception	cytoplasm|plasma membrane	all-trans-retinyl-palmitate hydrolase activity|metal ion binding|retinol isomerase activity			central_nervous_system(1)|kidney(3)|large_intestine(12)|lung(15)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	35						ATAGTCTCGTCACTGCACAGAA	0.470													44	119	---	---	---	---					
GBP7	388646	broad.mit.edu	37	1	89613321	89613322	+	Frame_Shift_Ins	INS	-	-	C	rs138127555		TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr1:89613321_89613322insC	ENST00000294671.2	-	8	1431_1432	c.1293_1294insG	c.(1291-1296)ggacaafs	p.Q432fs		NM_207398.2	NP_997281.2	Q8N8V2	GBP7_HUMAN	guanylate binding protein 7	432						integral to membrane	GTP binding|GTPase activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(2)|large_intestine(9)|lung(5)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	27		Lung NSC(277;0.0908)		all cancers(265;0.00835)|Epithelial(280;0.0322)		TAGATATTGTGCCCCCCCGGAA	0.436													10	254	---	---	---	---					
LRRC8C	84230	broad.mit.edu	37	1	90179646	90179647	+	Frame_Shift_Ins	INS	-	-	C			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr1:90179646_90179647insC	ENST00000370454.4	+	3	1772_1773	c.1517_1518insC	c.(1516-1518)cccfs	p.P506fs	RP11-302M6.4_ENST00000370453.5_Intron|LRRC8C_ENST00000479252.1_Intron	NM_032270.4	NP_115646.2	Q8TDW0	LRC8C_HUMAN	leucine rich repeat containing 8 family, member C	506						endoplasmic reticulum membrane|integral to membrane				breast(1)|central_nervous_system(1)|large_intestine(5)|lung(10)|ovary(3)|pancreas(1)|prostate(1)|skin(5)|urinary_tract(1)	28		all_lung(203;0.126)		all cancers(265;0.00756)|Epithelial(280;0.0313)		ATGAGGGAACTCCCCCCCTGGA	0.500													10	195	---	---	---	---					
EPHX4	253152	broad.mit.edu	37	1	92511121	92511122	+	Frame_Shift_Ins	INS	-	-	G			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr1:92511121_92511122insG	ENST00000370383.4	+	4	606_607	c.508_509insG	c.(508-510)gggfs	p.G170fs		NM_173567.4	NP_775838.3	Q8IUS5	EPHX4_HUMAN	epoxide hydrolase 4	170						integral to membrane	hydrolase activity			central_nervous_system(1)|large_intestine(3)|lung(8)	12						TGGCCATGACTGGGGGGGCATG	0.386													14	399	---	---	---	---					
FAM212B	55924	broad.mit.edu	37	1	112269658	112269659	+	Frame_Shift_Ins	INS	-	-	G			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr1:112269658_112269659insG	ENST00000357260.5	-	2	1006_1007	c.825_826insC	c.(823-828)cccaagfs	p.K276fs	FAM212B_ENST00000444059.2_Frame_Shift_Ins_p.K261fs|FAM212B_ENST00000534365.1_Intron	NM_019099.4	NP_061972.1	Q9NTI7	CA183_HUMAN	family with sequence similarity 212, member B	276										cervix(1)|endometrium(1)	2						GGGCAGCTTGTGGGGGGATTCT	0.574													8	1340	---	---	---	---					
OLFML3	56944	broad.mit.edu	37	1	114523958	114523959	+	Frame_Shift_Ins	INS	-	-	C			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr1:114523958_114523959insC	ENST00000369551.1	+	4	1016_1017	c.728_729insC	c.(727-729)accfs	p.T243fs	OLFML3_ENST00000393300.2_Frame_Shift_Ins_p.T243fs|OLFML3_ENST00000491700.1_3'UTR|OLFML3_ENST00000320334.4_Frame_Shift_Ins_p.T263fs			Q9NRN5	OLFL3_HUMAN	olfactomedin-like 3	263	Olfactomedin-like.				multicellular organismal development	extracellular region				breast(1)|endometrium(2)|large_intestine(3)|lung(3)|prostate(2)|skin(2)|urinary_tract(1)	14	Lung SC(450;0.184)	all_cancers(81;4.5e-08)|all_epithelial(167;1.09e-07)|all_lung(203;1.53e-05)|Lung NSC(69;2.76e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		GAGGGGCTGATCCCCCCCTACG	0.559													12	237	---	---	---	---					
SPAG17	200162	broad.mit.edu	37	1	118584454	118584455	+	Frame_Shift_Ins	INS	-	-	G			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr1:118584454_118584455insG	ENST00000336338.5	-	21	3090_3091	c.3025_3026insC	c.(3025-3027)ccafs	p.P1009fs		NM_206996.2	NP_996879.1	Q6Q759	SPG17_HUMAN	sperm associated antigen 17	1009						cilium|flagellar axoneme|microtubule				NS(1)|biliary_tract(1)|breast(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(30)|liver(2)|lung(56)|ovary(3)|prostate(5)|skin(5)|upper_aerodigestive_tract(6)|urinary_tract(1)	123	Esophageal squamous(2;0.0106)	all_cancers(81;0.0204)|all_lung(203;9.46e-05)|Lung NSC(69;0.000675)|all_epithelial(167;0.01)		Lung(183;0.0858)		TTCTGGTTGGTGGGGGGACTCT	0.371													8	880	---	---	---	---					
PIAS3	10401	broad.mit.edu	37	1	145585532	145585533	+	Frame_Shift_Ins	INS	-	-	G			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr1:145585532_145585533insG	ENST00000393045.2	+	14	1887_1888	c.1797_1798insG	c.(1795-1800)ccggggfs	p.PG599fs	PIAS3_ENST00000369298.1_Frame_Shift_Ins_p.PG564fs	NM_006099.3	NP_006090.2	Q9Y6X2	PIAS3_HUMAN	protein inhibitor of activated STAT, 3	599					positive regulation of protein sumoylation|protein sumoylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear speck	enzyme binding|nucleic acid binding|protein C-terminus binding|zinc ion binding			cervix(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(14)|ovary(1)|prostate(2)	28	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					TTGTGGCCCCTGGGGGGGCCTT	0.663													11	170	---	---	---	---					
BCL9	607	broad.mit.edu	37	1	147094075	147094076	+	Frame_Shift_Ins	INS	-	-	C			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr1:147094075_147094076insC	ENST00000234739.3	+	9	3646_3647	c.2906_2907insC	c.(2905-2907)gccfs	p.A969fs		NM_004326.2	NP_004317.2	O00512	BCL9_HUMAN	B-cell CLL/lymphoma 9	969	Pro-rich.				Wnt receptor signaling pathway	nucleus	protein binding			breast(1)|large_intestine(2)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	7	all_hematologic(923;0.115)					CTTTTAGGTGGCCCCCCACCTC	0.495			T	"""IGH@, IGL@"""	B-ALL								7	338	---	---	---	---					
TARS2	80222	broad.mit.edu	37	1	150477198	150477199	+	Frame_Shift_Ins	INS	-	-	G			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr1:150477198_150477199insG	ENST00000369064.3	+	15	1843_1844	c.1809_1810insG	c.(1807-1812)tgggggfs	p.WG603fs	TARS2_ENST00000606933.1_Frame_Shift_Ins_p.WG521fs|TARS2_ENST00000369054.2_Frame_Shift_Ins_p.WG473fs	NM_025150.3	NP_079426.2	Q9BW92	SYTM_HUMAN	threonyl-tRNA synthetase 2, mitochondrial (putative)	603					threonyl-tRNA aminoacylation	mitochondrial matrix	ATP binding|threonine-tRNA ligase activity	p.C603C(2)|p.G604W(1)		cervix(1)|endometrium(4)|large_intestine(7)|lung(19)|ovary(1)|pancreas(1)|skin(1)|urinary_tract(1)	35	all_cancers(9;3.13e-53)|all_epithelial(9;3.74e-43)|all_lung(15;2.43e-34)|Lung NSC(24;8.86e-31)|Breast(34;0.000326)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Melanoma(130;0.128)|Colorectal(459;0.171)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0757)|all cancers(9;1.51e-21)|BRCA - Breast invasive adenocarcinoma(12;0.000734)|LUSC - Lung squamous cell carcinoma(543;0.171)|STAD - Stomach adenocarcinoma(528;0.206)		L-Threonine(DB00156)	CAGAAAGCTGCGGGGGGAAATG	0.569													8	649	---	---	---	---					
ECM1	1893	broad.mit.edu	37	1	150482150	150482151	+	Frame_Shift_Ins	INS	-	-	C			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr1:150482150_150482151insC	ENST00000369047.4	+	3	260_261	c.135_136insC	c.(133-138)gcccccfs	p.AP45fs	ECM1_ENST00000346569.6_Frame_Shift_Ins_p.AP45fs|ECM1_ENST00000470432.1_3'UTR|ECM1_ENST00000369049.4_Frame_Shift_Ins_p.AP45fs	NM_004425.3	NP_004416.2	Q16610	ECM1_HUMAN	extracellular matrix protein 1	45					angiogenesis|biomineral tissue development|negative regulation of bone mineralization|negative regulation of peptidase activity|ossification|positive regulation of angiogenesis|positive regulation of endothelial cell proliferation|positive regulation of I-kappaB kinase/NF-kappaB cascade	proteinaceous extracellular matrix	laminin binding|protease binding|protein C-terminus binding|signal transducer activity			NS(1)|breast(2)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(1)|lung(7)|ovary(2)|prostate(3)|urinary_tract(1)	22	all_cancers(9;3.13e-53)|all_epithelial(9;3.74e-43)|all_lung(15;2.43e-34)|Lung NSC(24;8.86e-31)|Breast(34;0.000326)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Melanoma(130;0.128)|Colorectal(459;0.171)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0757)|all cancers(9;1.29e-21)|BRCA - Breast invasive adenocarcinoma(12;0.000734)|LUSC - Lung squamous cell carcinoma(543;0.171)|STAD - Stomach adenocarcinoma(528;0.206)			GCTACGCAGCTCCCCCCTCCCC	0.584													11	797	---	---	---	---					
ARNT	405	broad.mit.edu	37	1	150784508	150784509	+	Frame_Shift_Ins	INS	-	-	G			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr1:150784508_150784509insG	ENST00000358595.5	-	22	2558_2559	c.2358_2359insC	c.(2356-2361)cctttcfs	p.PF786fs	ARNT_ENST00000505755.1_Frame_Shift_Ins_p.PF771fs|ARNT_ENST00000354396.2_Frame_Shift_Ins_p.PF784fs|ARNT_ENST00000515192.1_Frame_Shift_Ins_p.PF772fs	NM_001197325.1|NM_001668.3|NM_178427.2	NP_001184254.1|NP_001659.1|NP_848514.1	P27540	ARNT_HUMAN	aryl hydrocarbon receptor nuclear translocator	786					positive regulation of hormone biosynthetic process|positive regulation vascular endothelial growth factor production|regulation of transcription from RNA polymerase II promoter in response to oxidative stress|response to hypoxia		aryl hydrocarbon receptor binding|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription coactivator activity			central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(9)|lung(11)|prostate(2)|skin(4)|stomach(1)	34	all_lung(15;9e-35)|Lung NSC(24;3.45e-31)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.108)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.02)|BRCA - Breast invasive adenocarcinoma(12;0.00606)|LUSC - Lung squamous cell carcinoma(543;0.211)			TATTCTGAAAAGGGGGGAAACA	0.376			T	ETV6	AML								7	299	---	---	---	---					
LCE1B	353132	broad.mit.edu	37	1	152785008	152785009	+	Frame_Shift_Ins	INS	-	-	C	rs151038984		TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr1:152785008_152785009insC	ENST00000360090.3	+	1	562_563	c.86_87insC	c.(85-87)tccfs	p.S29fs		NM_178349.1	NP_848126.1	Q5T7P3	LCE1B_HUMAN	late cornified envelope 1B	29	Pro-rich.				keratinization					breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(5)|skin(2)	18	Lung NSC(65;9.06e-30)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.171)			ACCCCTAGATGCCCCCCAAAGT	0.629													7	205	---	---	---	---					
CRTC2	200186	broad.mit.edu	37	1	153924672	153924673	+	Frame_Shift_Ins	INS	-	-	C			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr1:153924672_153924673insC	ENST00000368633.1	-	10	945_946	c.818_819insG	c.(817-819)gtcfs	p.V273fs	CRTC2_ENST00000368630.3_Intron	NM_181715.2	NP_859066.1	Q53ET0	CRTC2_HUMAN	CREB regulated transcription coactivator 2	273					interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	protein binding			NS(1)|breast(1)|cervix(2)|endometrium(4)|large_intestine(5)|lung(8)|ovary(3)|skin(1)|upper_aerodigestive_tract(2)	27	all_lung(78;3.05e-32)|Lung NSC(65;3.74e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)			CAGGTAGGGAGCCCCCCGTGTT	0.574													8	357	---	---	---	---					
UBE2Q1	55585	broad.mit.edu	37	1	154523415	154523416	+	Splice_Site	INS	-	-	T			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr1:154523415_154523416insT	ENST00000292211.4	-	12	1314_1315	c.1237_splice	c.e12+1	p.R412_splice		NM_017582.6	NP_060052.3	Q7Z7E8	UB2Q1_HUMAN	ubiquitin-conjugating enzyme E2Q family member 1	412							ATP binding|protein binding|ubiquitin-protein ligase activity	p.N412fs*>12(1)|p.G413fs*>11(1)		endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(3)|lung(6)|upper_aerodigestive_tract(1)	16	all_lung(78;1.72e-29)|Lung NSC(65;2.96e-27)|Hepatocellular(266;0.0877)|all_hematologic(923;0.088)		LUSC - Lung squamous cell carcinoma(543;0.185)			CAGCCTCACCGTTTTTTTCGTG	0.520													11	979	---	---	---	---					
ASH1L	55870	broad.mit.edu	37	1	155491185	155491186	+	Frame_Shift_Ins	INS	-	-	T			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr1:155491185_155491186insT	ENST00000368346.3	-	2	764_765	c.125_126insA	c.(124-126)aacfs	p.N42fs	ASH1L_ENST00000392403.3_Frame_Shift_Ins_p.N42fs|ASH1L_ENST00000548830.1_Frame_Shift_Ins_p.N42fs			Q9NR48	ASH1L_HUMAN	ash1 (absent, small, or homeotic)-like (Drosophila)	42					cell-cell signaling|DNA packaging|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	chromosome|Golgi apparatus|nucleus|tight junction	DNA binding|histone-lysine N-methyltransferase activity|zinc ion binding			autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|endometrium(12)|kidney(13)|large_intestine(28)|lung(39)|ovary(2)|pancreas(1)|prostate(6)|skin(11)|upper_aerodigestive_tract(2)|urinary_tract(4)	124	Hepatocellular(266;0.0997)|all_neural(408;0.129)|all_hematologic(923;0.145)		Epithelial(20;1.74e-08)|all cancers(21;3.29e-08)|BRCA - Breast invasive adenocarcinoma(34;0.021)			CCTCCTTTGTGTTTTTTTCTAG	0.431													10	1609	---	---	---	---					
MRPL24	79590	broad.mit.edu	37	1	156708444	156708445	+	Frame_Shift_Ins	INS	-	-	G			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr1:156708444_156708445insG	ENST00000368211.4	-	2	190_191	c.52_53insC	c.(52-54)ttafs	p.L18fs	MRPL24_ENST00000361531.2_Frame_Shift_Ins_p.L18fs	NM_024540.3|NM_145729.2	NP_078816.2|NP_663781.1	Q96A35	RM24_HUMAN	mitochondrial ribosomal protein L24	18					translation	mitochondrion|ribosome	structural constituent of ribosome			endometrium(1)|large_intestine(1)|lung(4)	6	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					ATAGCGGTAATGGGGGGGCAGA	0.574													7	184	---	---	---	---					
CD1C	911	broad.mit.edu	37	1	158262099	158262100	+	Frame_Shift_Ins	INS	-	-	C			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr1:158262099_158262100insC	ENST00000368170.3	+	3	833_834	c.554_555insC	c.(553-555)tccfs	p.S185fs		NM_001765.2	NP_001756.2	P29017	CD1C_HUMAN	CD1c molecule	185					antigen processing and presentation|T cell activation involved in immune response	endosome membrane|integral to plasma membrane	endogenous lipid antigen binding|exogenous lipid antigen binding|glycolipid binding|lipopeptide binding			NS(1)|endometrium(3)|large_intestine(4)|lung(21)|ovary(2)|pancreas(1)|prostate(1)|skin(4)|stomach(1)|urinary_tract(1)	39	all_hematologic(112;0.0378)					AGAAGCACTTGCCCCCGATTTC	0.450													9	2187	---	---	---	---					
IGSF9	57549	broad.mit.edu	37	1	159904586	159904587	+	Frame_Shift_Ins	INS	-	-	G			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr1:159904586_159904587insG	ENST00000368094.1	-	7	896_897	c.699_700insC	c.(697-702)ccagaafs	p.E234fs	IGSF9_ENST00000361509.3_Frame_Shift_Ins_p.E234fs	NM_001135050.1	NP_001128522.1	Q9P2J2	TUTLA_HUMAN	immunoglobulin superfamily, member 9	234	Ig-like 3.					cell junction|integral to membrane|synapse				central_nervous_system(2)|endometrium(8)|kidney(3)|large_intestine(13)|lung(17)|ovary(3)|prostate(4)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	56	all_hematologic(112;0.0597)	Breast(1374;0.000126)	BRCA - Breast invasive adenocarcinoma(70;0.111)			GTGCTGTTCTTGGGGGGCACCA	0.569													8	387	---	---	---	---					
PAPPA2	60676	broad.mit.edu	37	1	176762723	176762724	+	Frame_Shift_Ins	INS	-	-	C			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr1:176762723_176762724insC	ENST00000367662.3	+	20	6212_6213	c.5048_5049insC	c.(5047-5049)accfs	p.T1683fs		NM_020318.2	NP_064714.2	Q9BXP8	PAPP2_HUMAN	pappalysin 2	1683	Sushi 5.				cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			NS(3)|breast(3)|central_nervous_system(7)|cervix(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(19)|lung(136)|ovary(7)|pancreas(1)|prostate(4)|skin(10)|upper_aerodigestive_tract(8)|urinary_tract(1)	226						TTGTGTGTAATCCCCCCCAGTG	0.470													25	598	---	---	---	---					
ATP2B4	493	broad.mit.edu	37	1	203667345	203667346	+	Frame_Shift_Ins	INS	-	-	C			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr1:203667345_203667346insC	ENST00000357681.5	+	3	1377_1378	c.254_255insC	c.(253-255)accfs	p.T85fs	ATP2B4_ENST00000367219.3_Frame_Shift_Ins_p.T85fs|ATP2B4_ENST00000391954.2_Frame_Shift_Ins_p.T85fs|ATP2B4_ENST00000367218.3_Frame_Shift_Ins_p.T85fs|ATP2B4_ENST00000341360.2_Frame_Shift_Ins_p.T85fs	NM_001684.4	NP_001675.3	P23634	AT2B4_HUMAN	ATPase, Ca++ transporting, plasma membrane 4	85					ATP biosynthetic process|platelet activation	integral to plasma membrane	ATP binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding|protein binding			NS(1)|breast(1)|central_nervous_system(2)|cervix(2)|endometrium(5)|kidney(2)|large_intestine(10)|lung(20)|ovary(2)|prostate(6)|skin(1)|stomach(1)|urinary_tract(3)	56	all_cancers(21;0.071)|all_epithelial(62;0.228)		BRCA - Breast invasive adenocarcinoma(75;0.109)			CACAACGTGATCCCCCCCAAAA	0.480													11	255	---	---	---	---					
CR2	1380	broad.mit.edu	37	1	207642043	207642044	+	Frame_Shift_Ins	INS	-	-	C			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr1:207642043_207642044insC	ENST00000367057.3	+	3	806_807	c.617_618insC	c.(616-618)gccfs	p.A206fs	CR2_ENST00000367059.3_Frame_Shift_Ins_p.A206fs|CR2_ENST00000485707.1_3'UTR|CR2_ENST00000367058.3_Frame_Shift_Ins_p.A206fs|CR2_ENST00000458541.2_Frame_Shift_Ins_p.A206fs	NM_001006658.2	NP_001006659.1	P20023	CR2_HUMAN	complement component (3d/Epstein Barr virus) receptor 2	206	Sushi 3.				complement activation, classical pathway|innate immune response	integral to membrane|plasma membrane	complement receptor activity|protein homodimerization activity	p.T209fs*10(1)		NS(2)|breast(3)|endometrium(4)|kidney(3)|large_intestine(12)|lung(26)|ovary(1)|pancreas(1)|prostate(1)|skin(12)|upper_aerodigestive_tract(3)|urinary_tract(1)	69						TGGAGTGCTGTCCCCCCCACAT	0.396													12	456	---	---	---	---					
PROX1	5629	broad.mit.edu	37	1	214170285	214170286	+	Frame_Shift_Ins	INS	-	-	C			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr1:214170285_214170286insC	ENST00000366958.4	+	2	1015_1016	c.407_408insC	c.(406-408)accfs	p.T136fs	PROX1_ENST00000435016.1_Frame_Shift_Ins_p.T136fs|PROX1_ENST00000498508.2_Frame_Shift_Ins_p.T136fs|PROX1_ENST00000261454.4_Frame_Shift_Ins_p.T136fs	NM_001270616.1	NP_001257545.1	Q92786	PROX1_HUMAN	prospero homeobox 1	136					aorta smooth muscle tissue morphogenesis|atrial cardiac muscle tissue morphogenesis|brain development|dorsal spinal cord development|embryonic retina morphogenesis in camera-type eye|endocardium formation|hepatocyte differentiation|kidney development|lens fiber cell morphogenesis|lung development|lymphangiogenesis|negative regulation of bile acid biosynthetic process|negative regulation of cell proliferation|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of viral genome replication|neural tube development|olfactory placode formation|optic placode formation involved in camera-type eye formation|otic placode formation|pancreas development|positive regulation of cyclin-dependent protein kinase activity|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of heart growth|positive regulation of S phase of mitotic cell cycle|positive regulation of sarcomere organization|positive regulation of transcription, DNA-dependent|regulation of transcription involved in lymphatic endothelial cell fate commitment|skeletal muscle thin filament assembly|venous blood vessel morphogenesis|ventricular cardiac muscle tissue morphogenesis|ventricular cardiac myofibril development|ventricular septum morphogenesis	cytoplasm|nucleus	DBD domain binding|LBD domain binding|ligand-dependent nuclear receptor binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription corepressor activity|transcription regulatory region DNA binding			autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(6)|lung(15)|ovary(3)|prostate(2)|skin(4)	47				OV - Ovarian serous cystadenocarcinoma(81;0.0179)|all cancers(67;0.0488)|GBM - Glioblastoma multiforme(131;0.188)|Epithelial(68;0.219)		TCAAGAGACAGCCCCCCAGAGT	0.530													12	358	---	---	---	---					
ACTA1	58	broad.mit.edu	37	1	229567546	229567547	+	Frame_Shift_Ins	INS	-	-	C			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr1:229567546_229567547insC	ENST00000366684.3	-	6	1013_1014	c.911_912insG	c.(910-912)gacfs	p.D304fs	ACTA1_ENST00000366683.2_Frame_Shift_Ins_p.D216fs	NM_001100.3	NP_001091.1	P68133	ACTS_HUMAN	actin, alpha 1, skeletal muscle	304					muscle filament sliding|skeletal muscle fiber development|skeletal muscle thin filament assembly	actin filament|cytosol|stress fiber|striated muscle thin filament	ADP binding|ATP binding|myosin binding|structural constituent of cytoskeleton			endometrium(4)|large_intestine(4)|lung(18)|prostate(1)|urinary_tract(1)	28	Breast(184;0.0858)|Ovarian(103;0.103)	Prostate(94;0.167)			Dornase Alfa(DB00003)	ACATCGTGGTGCCCCCCGACAT	0.589													7	252	---	---	---	---					
NUP133	55746	broad.mit.edu	37	1	229600610	229600620	+	Frame_Shift_Del	DEL	GGACCACTTGT	GGACCACTTGT	-			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr1:229600610_229600620delGGACCACTTGT	ENST00000261396.3	-	18	2393_2403	c.2302_2312delACAAGTGGTCC	c.(2302-2313)tfs	p.TSGP768fs	NUP133_ENST00000366679.1_Frame_Shift_Del_p.TSGP768fs|NUP133_ENST00000537506.1_Frame_Shift_Del_p.TSGP752fs	NM_018230.2	NP_060700.2	Q8WUM0	NU133_HUMAN	nucleoporin 133kDa	768					carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA export from nucleus|nuclear pore organization|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytosol|Nup107-160 complex	nucleocytoplasmic transporter activity|protein binding			NS(1)|breast(7)|endometrium(1)|kidney(6)|large_intestine(9)|lung(20)|ovary(1)|pancreas(1)|prostate(3)|skin(3)|stomach(4)	56	Breast(184;0.104)|Ovarian(103;0.249)	Prostate(94;0.167)				GATGCCACCAGGACCACTTGTTGCTGTGAAA	0.436													13	191	---	---	---	---					
SIPA1L2	57568	broad.mit.edu	37	1	232650637	232650638	+	Frame_Shift_Ins	INS	-	-	G			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr1:232650637_232650638insG	ENST00000366630.1	-	2	806_807	c.448_449insC	c.(448-450)aagfs	p.K150fs	SIPA1L2_ENST00000262861.4_Frame_Shift_Ins_p.K150fs			Q9P2F8	SI1L2_HUMAN	signal-induced proliferation-associated 1 like 2	150					regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			NS(1)|breast(5)|central_nervous_system(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(13)|lung(49)|ovary(2)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	103		all_cancers(173;0.00605)|Prostate(94;0.128)|all_epithelial(177;0.186)				AAGTCCTCTTTGGGGGGAATGG	0.490													12	649	---	---	---	---					
ANTXR1	84168	broad.mit.edu	37	2	69409763	69409764	+	Frame_Shift_Ins	INS	-	-	C			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr2:69409763_69409764insC	ENST00000303714.4	+	16	1646_1647	c.1324_1325insC	c.(1324-1326)cccfs	p.P442fs		NM_032208.2	NP_115584.1	Q9H6X2	ANTR1_HUMAN	anthrax toxin receptor 1	442					actin cytoskeleton reorganization|substrate adhesion-dependent cell spreading	filopodium membrane|integral to membrane|lamellipodium membrane	actin filament binding|collagen binding|metal ion binding|protein binding|transmembrane receptor activity			haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(16)|ovary(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	29						TCGGCCTTCTTCCCCCCGGAAG	0.421									Familial Infantile Hemangioma				8	517	---	---	---	---					
RAB11FIP5	26056	broad.mit.edu	37	2	73302654	73302655	+	Frame_Shift_Ins	INS	-	-	G			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr2:73302654_73302655insG	ENST00000258098.6	-	5	2196_2197	c.1956_1957insC	c.(1954-1959)ccaatafs	p.I653fs	RAB11FIP5_ENST00000493523.2_5'UTR	NM_015470.2	NP_056285.1	Q9BXF6	RFIP5_HUMAN	RAB11 family interacting protein 5 (class I)	653					protein transport	mitochondrial outer membrane|recycling endosome membrane	gamma-tubulin binding			biliary_tract(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(9)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	23						GAAGGCTATTTGGGGGGGCCCG	0.629													20	264	---	---	---	---					
DCTN1	1639	broad.mit.edu	37	2	74593376	74593377	+	Frame_Shift_Ins	INS	-	-	G			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr2:74593376_74593377insG	ENST00000361874.3	-	23	3071_3072	c.2754_2755insC	c.(2752-2757)ccgcaafs	p.Q919fs	DCTN1_ENST00000407639.2_Frame_Shift_Ins_p.Q785fs|DCTN1_ENST00000409567.3_Frame_Shift_Ins_p.Q899fs|DCTN1_ENST00000394003.3_Frame_Shift_Ins_p.Q912fs|DCTN1_ENST00000409868.1_Frame_Shift_Ins_p.Q902fs|DCTN1_ENST00000409438.1_Frame_Shift_Ins_p.Q785fs|DCTN1_ENST00000409240.1_Frame_Shift_Ins_p.Q882fs|DCTN1_ENST00000495643.1_5'UTR	NM_004082.4	NP_004073.2	Q14203	DCTN1_HUMAN	dynactin 1	919					cell death|G2/M transition of mitotic cell cycle|mitosis|nervous system development	centrosome|cytosol|kinetochore|microtubule|spindle pole	motor activity|protein binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(20)|ovary(4)|prostate(1)|skin(3)	45						CCTACCTTGCTGGGGGGCCGCT	0.559													7	752	---	---	---	---					
HK2	3099	broad.mit.edu	37	2	75104377	75104378	+	Frame_Shift_Ins	INS	-	-	G			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr2:75104377_75104378insG	ENST00000290573.2	+	8	1560_1561	c.960_961insG	c.(958-963)ttggggfs	p.LG320fs	HK2_ENST00000409174.1_Frame_Shift_Ins_p.LG292fs	NM_000189.4	NP_000180.2	P52789	HXK2_HUMAN	hexokinase 2	320	Regulatory.				apoptotic mitochondrial changes|glucose transport|glycolysis|transmembrane transport	cytosol|mitochondrial outer membrane	ATP binding|glucokinase activity			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(5)|lung(22)|ovary(2)|prostate(1)|skin(2)|stomach(1)|urinary_tract(1)	43						AGCTGCTCTTTGGGGGGAAGCT	0.545													8	662	---	---	---	---					
IL1R2	7850	broad.mit.edu	37	2	102638681	102638682	+	Frame_Shift_Ins	INS	-	-	C			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr2:102638681_102638682insC	ENST00000332549.3	+	6	950_951	c.721_722insC	c.(721-723)cccfs	p.P241fs	IL1R2_ENST00000441002.1_Frame_Shift_Ins_p.P241fs|IL1R2_ENST00000393414.2_Frame_Shift_Ins_p.P241fs	NM_004633.3	NP_004624.1	P27930	IL1R2_HUMAN	interleukin 1 receptor, type II	241	Ig-like C2-type 3.				immune response	integral to membrane|plasma membrane	interleukin-1, Type II, blocking receptor activity			breast(3)|endometrium(1)|kidney(1)|large_intestine(8)|lung(13)|ovary(1)|skin(1)	28					Anakinra(DB00026)	TGTGATCATTTCCCCCCTCAAG	0.490													9	657	---	---	---	---					
XIRP2	129446	broad.mit.edu	37	2	168099957	168099958	+	Frame_Shift_Ins	INS	-	-	G			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr2:168099957_168099958insG	ENST00000409195.1	+	9	2144_2145	c.2055_2056insG	c.(2053-2058)acggggfs	p.TG685fs	XIRP2_ENST00000409756.2_Intron|XIRP2_ENST00000409728.1_Intron|XIRP2_ENST00000409273.1_Frame_Shift_Ins_p.TG463fs|XIRP2_ENST00000409605.1_Intron|XIRP2_ENST00000295237.9_Frame_Shift_Ins_p.TG685fs|XIRP2_ENST00000409043.1_Intron|XIRP2_ENST00000420519.1_Intron	NM_152381.5	NP_689594.4	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2	510					actin cytoskeleton organization	cell junction	actin binding			NS(3)|biliary_tract(2)|breast(5)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(51)|lung(160)|ovary(7)|pancreas(3)|prostate(11)|skin(14)|stomach(5)|upper_aerodigestive_tract(8)|urinary_tract(7)	315						AGGACATAACTGGGGGGGATGT	0.421													12	299	---	---	---	---					
MYO3B	140469	broad.mit.edu	37	2	171240258	171240259	+	Frame_Shift_Ins	INS	-	-	C			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr2:171240258_171240259insC	ENST00000334231.6	+	12	1251_1252	c.1251_1252insC	c.(1249-1254)aaccccfs	p.NP417fs	MYO3B_ENST00000409044.3_Frame_Shift_Ins_p.NP408fs|MYO3B_ENST00000602629.1_3'UTR|MYO3B_ENST00000408978.4_Frame_Shift_Ins_p.NP408fs			Q8WXR4	MYO3B_HUMAN	myosin IIIB	408	Myosin head-like.				response to stimulus|visual perception	cytoplasm|myosin complex	actin binding|ATP binding|motor activity|protein serine/threonine kinase activity			breast(1)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(25)|ovary(6)|pancreas(1)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	59						GCGCCTCCAATCCCCCCCACAT	0.465													8	270	---	---	---	---					
PDE11A	50940	broad.mit.edu	37	2	178936666	178936667	+	Frame_Shift_Ins	INS	-	-	G			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr2:178936666_178936667insG	ENST00000286063.5	-	1	815_816	c.498_499insC	c.(496-501)ccccacfs	p.H167fs	PDE11A_ENST00000358450.4_Intron	NM_016953.3	NP_058649.3	Q9HCR9	PDE11_HUMAN	phosphodiesterase 11A	167					platelet activation|signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|metal ion binding			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(13)|lung(28)|ovary(4)|skin(3)|upper_aerodigestive_tract(3)	58			OV - Ovarian serous cystadenocarcinoma(117;0.00121)|Epithelial(96;0.00455)|all cancers(119;0.02)			TGGGCTGTGGTGGGGGGCAGGG	0.564									Primary Pigmented Nodular Adrenocortical Disease, Familial				10	306	---	---	---	---					
NEUROD1	4760	broad.mit.edu	37	2	182542971	182542972	+	Frame_Shift_Ins	INS	-	-	G			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr2:182542971_182542972insG	ENST00000295108.3	-	2	1073_1074	c.616_617insC	c.(616-618)cctfs	p.P206fs	NEUROD1_ENST00000496876.1_Intron|CERKL_ENST00000479558.1_Intron	NM_002500.4	NP_002491.2	Q13562	NDF1_HUMAN	neuronal differentiation 1	206					amacrine cell differentiation|cerebellum development|dentate gyrus development|embryonic organ morphogenesis|enteroendocrine cell differentiation|glucose homeostasis|inner ear development|insulin secretion|negative regulation of apoptosis|nitric oxide mediated signal transduction|positive regulation of apoptosis|positive regulation of neuron differentiation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of cell cycle arrest|regulation of intestinal epithelial structure maintenance|response to glucose stimulus	cytoplasm|nucleus	chromatin binding|E-box binding|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription factor binding			endometrium(3)|kidney(1)|large_intestine(6)|lung(9)|ovary(3)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	25			OV - Ovarian serous cystadenocarcinoma(117;0.088)			CGTCGGCAGGTGGGGGGGCATG	0.619													12	359	---	---	---	---					
ITGAV	3685	broad.mit.edu	37	2	187521084	187521085	+	Frame_Shift_Ins	INS	-	-	G			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr2:187521084_187521085insG	ENST00000261023.3	+	17	1949_1950	c.1675_1676insG	c.(1675-1677)gggfs	p.G559fs	ITGAV_ENST00000374907.3_Frame_Shift_Ins_p.G523fs|ITGAV_ENST00000433736.2_Frame_Shift_Ins_p.G513fs|AC017101.10_ENST00000453665.1_RNA	NM_002210.3	NP_002201.1	P06756	ITAV_HUMAN	integrin, alpha V	559					angiogenesis|axon guidance|blood coagulation|cell-matrix adhesion|entry of bacterium into host cell|entry of symbiont into host cell by promotion of host phagocytosis|entry of virus into host cell|ERK1 and ERK2 cascade|integrin-mediated signaling pathway|leukocyte migration|negative regulation of apoptosis|negative regulation of lipid storage|negative regulation of lipid transport|negative regulation of lipoprotein metabolic process|negative regulation of low-density lipoprotein particle receptor biosynthetic process|negative regulation of macrophage derived foam cell differentiation|positive regulation of cell adhesion|positive regulation of cell proliferation|regulation of apoptotic cell clearance	integrin complex	receptor activity|transforming growth factor beta binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(6)|lung(19)|ovary(2)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	47			OV - Ovarian serous cystadenocarcinoma(117;0.0185)|Epithelial(96;0.072)|all cancers(119;0.189)	STAD - Stomach adenocarcinoma(3;0.106)|COAD - Colon adenocarcinoma(31;0.108)		GACTATTTCAAGGGGGGGACTG	0.431													22	558	---	---	---	---					
FAM117B	150864	broad.mit.edu	37	2	203621968	203621969	+	Frame_Shift_Ins	INS	-	-	C			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr2:203621968_203621969insC	ENST00000303116.6	+	6	1147_1148	c.405_406insC	c.(403-408)ccccccfs	p.PP135fs	FAM117B_ENST00000392238.2_Frame_Shift_Ins_p.PP379fs	NM_173511.3	NP_775782.2	Q6P1L5	F117B_HUMAN	family with sequence similarity 117, member B	379										breast(3)|central_nervous_system(1)|cervix(1)|endometrium(2)|large_intestine(4)|lung(5)|ovary(1)	17						ATCGTGCTCCACCCCCCCTTGT	0.485													12	146	---	---	---	---					
ADAM23	8745	broad.mit.edu	37	2	207460860	207460861	+	Frame_Shift_Ins	INS	-	-	C			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr2:207460860_207460861insC	ENST00000264377.3	+	24	2661_2662	c.2333_2334insC	c.(2332-2334)cccfs	p.P778fs	ADAM23_ENST00000374416.1_Frame_Shift_Ins_p.P778fs|ADAM23_ENST00000374415.3_Frame_Shift_Ins_p.P778fs	NM_003812.2	NP_003803.1	O75077	ADA23_HUMAN	ADAM metallopeptidase domain 23	778					cell adhesion|central nervous system development|proteolysis	extracellular region|integral to plasma membrane	integrin binding|metalloendopeptidase activity|zinc ion binding	p.K781fs*3(2)		NS(2)|breast(1)|endometrium(6)|kidney(3)|large_intestine(5)|liver(2)|lung(22)|ovary(2)|prostate(3)|skin(3)|stomach(1)|urinary_tract(1)	51				LUSC - Lung squamous cell carcinoma(261;0.0961)|Lung(261;0.182)|Epithelial(149;0.205)		AGGAACCTTCACCCCCCCAAGG	0.455													10	128	---	---	---	---					
UGT1A4	54657	broad.mit.edu	37	2	234627976	234627977	+	Frame_Shift_Ins	INS	-	-	T			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr2:234627976_234627977insT	ENST00000373409.3	+	1	553_554	c.510_511insT	c.(508-513)gtttttfs	p.VF170fs	UGT1A5_ENST00000373414.3_Intron|UGT1A8_ENST00000373450.4_Intron|UGT1A6_ENST00000373424.1_Intron|UGT1A10_ENST00000373445.1_Intron|UGT1A6_ENST00000406651.1_Intron|UGT1A7_ENST00000373426.3_Intron|UGT1A9_ENST00000354728.4_Intron|UGT1A6_ENST00000305139.6_Intron|UGT1A10_ENST00000344644.5_Intron|UGT1A6_ENST00000480628.1_Intron	NM_007120.2	NP_009051.1														autonomic_ganglia(1)|breast(2)|endometrium(3)|kidney(2)|large_intestine(5)|lung(9)|ovary(1)|skin(2)|urinary_tract(1)	26		Breast(86;0.000765)|all_lung(227;0.00266)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0327)|Lung NSC(271;0.0456)|Lung SC(224;0.128)		Epithelial(121;3.49e-18)|BRCA - Breast invasive adenocarcinoma(100;0.000504)|Lung(119;0.0026)|LUSC - Lung squamous cell carcinoma(224;0.00624)		TTCCTGCTGTGTTTTTTTGGAG	0.455													9	624	---	---	---	---					
NDUFA10	4705	broad.mit.edu	37	2	240954220	240954221	+	Frame_Shift_Ins	INS	-	-	G			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr2:240954220_240954221insG	ENST00000252711.2	-	5	704_705	c.604_605insC	c.(604-606)cctfs	p.P202fs	NDUFA10_ENST00000404554.1_Frame_Shift_Ins_p.P202fs|NDUFA10_ENST00000307300.4_Frame_Shift_Ins_p.P242fs	NM_004544.3	NP_004535.1	O95299	NDUAA_HUMAN	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 10, 42kDa	202					mitochondrial electron transport, NADH to ubiquinone|nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|transport	mitochondrial matrix|mitochondrial respiratory chain complex I	ATP binding|NADH dehydrogenase (ubiquinone) activity|phosphotransferase activity, alcohol group as acceptor			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(8)	16		all_epithelial(40;4.26e-15)|Breast(86;4.4e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0396)|Lung NSC(271;0.128)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(121;7.82e-28)|OV - Ovarian serous cystadenocarcinoma(60;1.5e-13)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;6.5e-08)|BRCA - Breast invasive adenocarcinoma(100;2.39e-05)|Lung(119;0.00519)|LUSC - Lung squamous cell carcinoma(224;0.0202)	NADH(DB00157)	AATCACCAGGTGGGGGGGCAGG	0.535													15	383	---	---	---	---					
HDLBP	3069	broad.mit.edu	37	2	242195692	242195693	+	Frame_Shift_Ins	INS	-	-	G			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr2:242195692_242195693insG	ENST00000391975.1	-	7	1006_1007	c.779_780insC	c.(778-780)cccfs	p.P260fs	HDLBP_ENST00000310931.4_Frame_Shift_Ins_p.P260fs|HDLBP_ENST00000427183.2_Frame_Shift_Ins_p.P296fs|HDLBP_ENST00000391976.2_Frame_Shift_Ins_p.P260fs	NM_203346.3	NP_976221.1	Q00341	VIGLN_HUMAN	high density lipoprotein binding protein	260	KH 2.				cholesterol metabolic process|lipid transport	cytoplasm|high-density lipoprotein particle|nucleus|plasma membrane	lipid binding|protein binding|RNA binding			breast(7)|cervix(1)|endometrium(8)|kidney(1)|large_intestine(11)|lung(8)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	44		all_cancers(19;7.77e-41)|all_epithelial(40;1.74e-18)|Breast(86;1.53e-05)|Renal(207;0.00179)|all_lung(227;0.00338)|Ovarian(221;0.00556)|Lung NSC(271;0.0121)|Esophageal squamous(248;0.129)|all_hematologic(139;0.158)|Melanoma(123;0.16)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;8.13e-34)|all cancers(36;4.71e-31)|OV - Ovarian serous cystadenocarcinoma(60;2.34e-15)|Kidney(56;3.72e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.76e-08)|BRCA - Breast invasive adenocarcinoma(100;3.38e-06)|Lung(119;0.000109)|LUSC - Lung squamous cell carcinoma(224;0.000964)|Colorectal(34;0.0132)|COAD - Colon adenocarcinoma(134;0.0928)		TCACGCTGGGTGGGGGGATGTT	0.530													8	226	---	---	---	---					
PBRM1	55193	broad.mit.edu	37	3	52702569	52702569	+	Frame_Shift_Del	DEL	T	T	-			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr3:52702569delT	ENST00000356770.4	-	3	331	c.329delA	c.(328-330)atfs	p.N110fs	PBRM1_ENST00000410007.1_Frame_Shift_Del_p.N110fs|PBRM1_ENST00000409114.3_Frame_Shift_Del_p.N110fs|PBRM1_ENST00000394830.3_Frame_Shift_Del_p.N110fs|PBRM1_ENST00000337303.4_Frame_Shift_Del_p.N110fs|PBRM1_ENST00000296302.7_Frame_Shift_Del_p.N110fs|PBRM1_ENST00000409767.1_Frame_Shift_Del_p.N110fs|PBRM1_ENST00000409057.1_Frame_Shift_Del_p.N110fs			Q86U86	PB1_HUMAN	polybromo 1	110	Bromo 1.				chromatin remodeling|mitosis|negative regulation of cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear chromosome	chromatin binding|DNA binding|protein binding	p.N110fs*3(3)		breast(5)|endometrium(5)|kidney(301)|liver(1)|lung(22)|pancreas(1)	335				BRCA - Breast invasive adenocarcinoma(193;1.8e-05)|Kidney(197;0.00105)|KIRC - Kidney renal clear cell carcinoma(197;0.00122)|OV - Ovarian serous cystadenocarcinoma(275;0.0613)		AGTCAGCAAATTAACATCATC	0.328			"""Mis, N, F, S, D, O"""		"""clear cell renal carcinoma, breast"""								21	38	---	---	---	---					
PIK3CB	5291	broad.mit.edu	37	3	138413709	138413710	+	Frame_Shift_Ins	INS	-	-	G			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr3:138413709_138413710insG	ENST00000477593.1	-	13	1883_1884	c.1810_1811insC	c.(1810-1812)ggafs	p.G604fs	PIK3CB_ENST00000544716.1_Frame_Shift_Ins_p.G50fs|PIK3CB_ENST00000289153.2_Frame_Shift_Ins_p.G604fs			P42338	PK3CB_HUMAN	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta	604	PI3K helical.				activation of MAPK activity|chemotaxis|fibroblast growth factor receptor signaling pathway|G-protein coupled receptor protein signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell receptor signaling pathway	phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity			NS(1)|breast(3)|endometrium(5)|kidney(2)|large_intestine(4)|lung(17)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(4)	41						TAGGGCCTCCCGGGGGGGCAGT	0.465													8	146	---	---	---	---					
COPB2	9276	broad.mit.edu	37	3	139090606	139090606	+	Frame_Shift_Del	DEL	A	A	-			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr3:139090606delA	ENST00000333188.5	-	10	1345	c.1164delT	c.(1162-1164)ttfs	p.F388fs	COPB2_ENST00000507777.1_Frame_Shift_Del_p.F359fs	NM_004766.2	NP_004757.1	P35606	COPB2_HUMAN	coatomer protein complex, subunit beta 2 (beta prime)	388					COPI coating of Golgi vesicle|intra-Golgi vesicle-mediated transport|intracellular protein transport|retrograde vesicle-mediated transport, Golgi to ER	COPI vesicle coat|cytosol	protein binding|structural molecule activity			breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(4)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	24						GAGCAGATCCAAAGCTCTTGT	0.468													116	263	---	---	---	---					
HTR3E	285242	broad.mit.edu	37	3	183823745	183823746	+	Frame_Shift_Ins	INS	-	-	C			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr3:183823745_183823746insC	ENST00000415389.2	+	7	1379_1380	c.913_914insC	c.(913-915)cccfs	p.P305fs	HTR3E_ENST00000440596.2_Frame_Shift_Ins_p.P331fs|HTR3E_ENST00000425359.2_Frame_Shift_Ins_p.P290fs|HTR3E_ENST00000436361.2_Frame_Shift_Ins_p.P305fs|HTR3E_ENST00000335304.2_Frame_Shift_Ins_p.P320fs	NM_001256613.1|NM_198313.2	NP_001243542.1|NP_938055.1	A5X5Y0	5HT3E_HUMAN	5-hydroxytryptamine (serotonin) receptor 3E, ionotropic	305						integral to membrane|plasma membrane|postsynaptic membrane	extracellular ligand-gated ion channel activity|receptor activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(8)|lung(20)|ovary(1)|skin(2)|upper_aerodigestive_tract(2)	40	all_cancers(143;1.46e-10)|Ovarian(172;0.0303)		Epithelial(37;7.06e-36)|OV - Ovarian serous cystadenocarcinoma(80;3.11e-22)			CACCAGTGGCACCCCCCTCATC	0.540													9	580	---	---	---	---					
FETUB	26998	broad.mit.edu	37	3	186370136	186370137	+	Frame_Shift_Ins	INS	-	-	C			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr3:186370136_186370137insC	ENST00000265029.3	+	7	966_967	c.865_866insC	c.(865-867)cccfs	p.P289fs	FETUB_ENST00000539949.1_Frame_Shift_Ins_p.P141fs|FETUB_ENST00000382134.3_Frame_Shift_Ins_p.P224fs|FETUB_ENST00000382136.3_Frame_Shift_Ins_p.P252fs|RP11-134F2.2_ENST00000455926.1_RNA|RP11-134F2.2_ENST00000428501.1_RNA|FETUB_ENST00000450521.1_Frame_Shift_Ins_p.P289fs	NM_014375.2	NP_055190.2	Q9UGM5	FETUB_HUMAN	fetuin B	289						extracellular space	cysteine-type endopeptidase inhibitor activity			endometrium(1)|kidney(1)|large_intestine(4)|lung(13)|ovary(1)	20	all_cancers(143;6.64e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;5.73e-20)	GBM - Glioblastoma multiforme(93;0.0479)		GCAGAAAAACACCCCCCCAACA	0.495													16	308	---	---	---	---					
UBXN7	26043	broad.mit.edu	37	3	196094916	196094917	+	Frame_Shift_Ins	INS	-	-	G			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr3:196094916_196094917insG	ENST00000296328.4	-	8	890_891	c.816_817insC	c.(814-819)ccaaaafs	p.PK272fs	UBXN7_ENST00000535858.1_Frame_Shift_Ins_p.PK124fs|UBXN7_ENST00000428095.1_Frame_Shift_Ins_p.PK110fs	NM_015562.1	NP_056377.1	O94888	UBXN7_HUMAN	UBX domain protein 7	272							protein binding			NS(1)|endometrium(2)|large_intestine(4)|lung(6)|ovary(2)|pancreas(1)|prostate(1)|skin(1)	18						GCACATTTTTTGGGGGGACTGC	0.396													7	406	---	---	---	---					
KIAA0226	9711	broad.mit.edu	37	3	197427914	197427915	+	Frame_Shift_Ins	INS	-	-	G			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr3:197427914_197427915insG	ENST00000273582.5	-	7	1195_1196	c.650_651insC	c.(649-651)cgtfs	p.R217fs	KIAA0226_ENST00000389665.5_Frame_Shift_Ins_p.R277fs|KIAA0226_ENST00000449205.1_Frame_Shift_Ins_p.R277fs|KIAA0226_ENST00000296343.5_Frame_Shift_Ins_p.R277fs	NM_001145642.2	NP_001139114.1	Q92622	RUBIC_HUMAN	KIAA0226	277	Ser-rich.				autophagy|endocytosis|negative regulation of autophagy|negative regulation of endocytosis	early endosome|late endosome|lysosome	protein binding			NS(2)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(13)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	31	all_cancers(143;8.26e-10)|Ovarian(172;0.0418)|Breast(254;0.0976)		Epithelial(36;2.19e-23)|all cancers(36;1.39e-21)|OV - Ovarian serous cystadenocarcinoma(49;1.21e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(93;0.0446)		AGACTGAAACTGGGGGGGCTTG	0.554													8	158	---	---	---	---					
FAM193A	8603	broad.mit.edu	37	4	2661592	2661593	+	Frame_Shift_Ins	INS	-	-	C			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr4:2661592_2661593insC	ENST00000324666.5	+	8	1034_1035	c.683_684insC	c.(682-684)gccfs	p.A228fs	FAM193A_ENST00000505311.1_Frame_Shift_Ins_p.A228fs|FAM193A_ENST00000545951.1_Frame_Shift_Ins_p.A228fs|FAM193A_ENST00000502458.1_Frame_Shift_Ins_p.A252fs|FAM193A_ENST00000382839.3_Frame_Shift_Ins_p.A228fs	NM_001256666.1	NP_001243595.1	P78312	F193A_HUMAN	family with sequence similarity 193, member A	228										NS(2)|breast(1)|endometrium(4)|kidney(4)|large_intestine(3)|lung(12)|ovary(4)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(3)	40						GGTATCATGGACCCCCCCGTCA	0.525													8	647	---	---	---	---					
EVC	2121	broad.mit.edu	37	4	5785361	5785362	+	Frame_Shift_Ins	INS	-	-	C			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr4:5785361_5785362insC	ENST00000382674.2	+	12	1830_1831	c.1646_1647insC	c.(1645-1647)cccfs	p.P549fs	EVC_ENST00000264956.6_Frame_Shift_Ins_p.P549fs			P57679	EVC_HUMAN	Ellis van Creveld syndrome	549					muscle organ development	integral to membrane				NS(1)|breast(1)|endometrium(2)|large_intestine(10)|lung(11)|ovary(1)|skin(1)|stomach(1)	28		Myeloproliferative disorder(84;0.117)				ATGACTGGCCTCCCCCCGGAAG	0.584													12	589	---	---	---	---					
ANKRD17	26057	broad.mit.edu	37	4	73956600	73956601	+	Frame_Shift_Ins	INS	-	-	G			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr4:73956600_73956601insG	ENST00000358602.4	-	29	6860_6861	c.6744_6745insC	c.(6742-6747)cctaccfs	p.T2249fs	ANKRD17_ENST00000330838.6_Frame_Shift_Ins_p.T1998fs|ANKRD17_ENST00000509867.2_Frame_Shift_Ins_p.T2136fs	NM_032217.3	NP_115593.3	O75179	ANR17_HUMAN	ankyrin repeat domain 17	2249					interspecies interaction between organisms	cytoplasm|nucleus	RNA binding			NS(3)|breast(2)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(39)|ovary(6)|pancreas(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(3)	96	Breast(15;0.000295)		Epithelial(6;8.86e-07)|OV - Ovarian serous cystadenocarcinoma(6;6.22e-06)|all cancers(17;1.51e-05)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			CCAAATGGTAAGGGGGCACTGA	0.460													7	935	---	---	---	---					
UNC5C	8633	broad.mit.edu	37	4	96091356	96091357	+	Frame_Shift_Ins	INS	-	-	G			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr4:96091356_96091357insG	ENST00000453304.1	-	15	2926_2927	c.2578_2579insC	c.(2578-2580)gacfs	p.D860fs		NM_003728.3	NP_003719.3	O95185	UNC5C_HUMAN	unc-5 homolog C (C. elegans)	860	Death.				apoptosis|axon guidance|brain development	integral to membrane	netrin receptor activity			NS(1)|breast(2)|endometrium(2)|kidney(1)|large_intestine(14)|lung(25)|ovary(3)|pancreas(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	55		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;8.72e-10)		GCCTCTCGTCTGGGGGGCATCC	0.599													7	534	---	---	---	---					
TLR3	7098	broad.mit.edu	37	4	186997804	186997805	+	Frame_Shift_Ins	INS	-	-	G			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr4:186997804_186997805insG	ENST00000296795.2	+	2	135_136	c.31_32insG	c.(31-33)gggfs	p.G11fs		NM_003265.2	NP_003256.1	O15455	TLR3_HUMAN	toll-like receptor 3	11					activation of NF-kappaB-inducing kinase activity|cellular response to mechanical stimulus|defense response to bacterium|defense response to virus|detection of virus|hyperosmotic response|I-kappaB phosphorylation|inflammatory response|innate immune response|MyD88-independent toll-like receptor signaling pathway|negative regulation of osteoclast differentiation|positive regulation of chemokine production|positive regulation of interferon-alpha biosynthetic process|positive regulation of interferon-beta biosynthetic process|positive regulation of interferon-beta production|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-12 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of toll-like receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|toll-like receptor 3 signaling pathway	endoplasmic reticulum membrane|endosome membrane|integral to plasma membrane	double-stranded RNA binding|transmembrane receptor activity			breast(1)|endometrium(5)|large_intestine(8)|lung(8)|ovary(2)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	29		all_cancers(14;4.27e-52)|all_epithelial(14;7.69e-39)|all_lung(41;1.34e-13)|Lung NSC(41;3.58e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.0066)|Hepatocellular(41;0.00886)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|all_neural(102;0.243)		OV - Ovarian serous cystadenocarcinoma(60;1.47e-11)|BRCA - Breast invasive adenocarcinoma(30;1.14e-05)|GBM - Glioblastoma multiforme(59;0.000107)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.16)		TATCTACTTTTGGGGGGGCCTT	0.446													12	280	---	---	---	---					
FAT1	2195	broad.mit.edu	37	4	187558038	187558039	+	Frame_Shift_Ins	INS	-	-	G			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr4:187558038_187558039insG	ENST00000441802.2	-	5	3881_3882	c.3672_3673insC	c.(3670-3675)ccaatcfs	p.I1225fs		NM_005245.3	NP_005236.2	Q14517	FAT1_HUMAN	FAT atypical cadherin 1	1225	Cadherin 10.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(38)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(33)|lung(88)|ovary(13)|pancreas(2)|prostate(16)|skin(2)|upper_aerodigestive_tract(11)|urinary_tract(4)	228						ATGGTTGATTTGGGGGGACTAC	0.361										HNSCC(5;0.00058)			11	986	---	---	---	---					
TRIML2	205860	broad.mit.edu	37	4	189012770	189012771	+	Frame_Shift_Ins	INS	-	-	G			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr4:189012770_189012771insG	ENST00000512729.1	-	7	1294_1295	c.920_921insC	c.(919-921)cctfs	p.P307fs	TRIML2_ENST00000326754.3_Frame_Shift_Ins_p.P332fs	NM_173553.1	NP_775824.1	Q8N7C3	TRIMM_HUMAN	tripartite motif family-like 2	307	B30.2/SPRY.						ligase activity			central_nervous_system(2)|kidney(1)|large_intestine(7)|lung(25)|prostate(3)|urinary_tract(1)	39		all_cancers(14;3.11e-44)|all_epithelial(14;7.86e-31)|all_lung(41;4.3e-13)|Lung NSC(41;9.69e-13)|Melanoma(20;7.86e-05)|Breast(6;0.000148)|all_hematologic(60;0.0202)|Hepatocellular(41;0.0218)|Renal(120;0.0376)|Prostate(90;0.0513)		OV - Ovarian serous cystadenocarcinoma(60;1.79e-11)|BRCA - Breast invasive adenocarcinoma(30;4.52e-06)|GBM - Glioblastoma multiforme(59;1.62e-05)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.0091)|READ - Rectum adenocarcinoma(43;0.163)		GCCTTTTCAGAGGGGGGAAGAC	0.559													8	663	---	---	---	---					
GCNT4	51301	broad.mit.edu	37	5	74324982	74324983	+	Frame_Shift_Ins	INS	-	-	G			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr5:74324982_74324983insG	ENST00000322348.4	-	1	1741_1742	c.880_881insC	c.(880-882)taafs	p.*294fs		NM_016591.2	NP_057675.1	Q9P109	GCNT4_HUMAN	glucosaminyl (N-acetyl) transferase 4, core 2	294					protein O-linked glycosylation	Golgi membrane|integral to membrane	beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity|N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity	p.H294fs*2(1)		NS(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(3)|ovary(2)|skin(1)|stomach(2)	19		all_lung(232;0.0131)|Lung NSC(167;0.0282)|Ovarian(174;0.0798)		OV - Ovarian serous cystadenocarcinoma(47;8.44e-57)		CTGAATGTTATGGGGGGGTGCT	0.366													13	211	---	---	---	---					
PCSK1	5122	broad.mit.edu	37	5	95746639	95746640	+	Frame_Shift_Ins	INS	-	-	C			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr5:95746639_95746640insC	ENST00000311106.3	-	8	1170_1171	c.933_934insG	c.(931-936)gggtcafs	p.S312fs	PCSK1_ENST00000508626.1_Frame_Shift_Ins_p.S265fs|PCSK1_ENST00000513085.1_Intron|CTD-2337A12.1_ENST00000502645.2_RNA	NM_000439.4|NM_001177876.1	NP_000430.3|NP_001171347.1	P29120	NEC1_HUMAN	proprotein convertase subtilisin/kexin type 1	312	Catalytic.				cell-cell signaling|cellular nitrogen compound metabolic process|energy reserve metabolic process|hormone biosynthetic process|peptide biosynthetic process|peptide hormone processing|regulation of insulin secretion	extracellular space|stored secretory granule|transport vesicle	serine-type endopeptidase activity	p.R312C(1)		NS(1)|endometrium(3)|kidney(3)|large_intestine(5)|lung(14)|ovary(2)|prostate(3)|skin(3)|urinary_tract(2)	36		all_cancers(142;2.67e-06)|all_epithelial(76;6.92e-09)|all_lung(232;0.00307)|Lung NSC(167;0.00452)|Ovarian(225;0.0112)|Colorectal(57;0.0341)|Breast(839;0.244)		all cancers(79;3.44e-16)	Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	TCTCCCTGACGCCCCCCGTTTC	0.530													7	380	---	---	---	---					
FBN2	2201	broad.mit.edu	37	5	127610310	127610311	+	Frame_Shift_Ins	INS	-	-	C	rs151053868		TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr5:127610310_127610311insC	ENST00000508053.1	-	66	8633_8634	c.7659_7660insG	c.(7657-7662)ggttacfs	p.Y2554fs	FBN2_ENST00000262464.4_Frame_Shift_Ins_p.Y2554fs			P35556	FBN2_HUMAN	fibrillin 2	2554	EGF-like 43; calcium-binding.				bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			NS(1)|autonomic_ganglia(1)|biliary_tract(1)|breast(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(37)|liver(1)|lung(89)|ovary(9)|pancreas(2)|prostate(6)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	197		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)		TTACAGGTAAACCCCCCCAGGG	0.421													12	255	---	---	---	---					
SLC25A48	153328	broad.mit.edu	37	5	135207263	135207264	+	Frame_Shift_Ins	INS	-	-	G			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr5:135207263_135207264insG	ENST00000274513.5	+	5	707_708	c.535_536insG	c.(535-537)gggfs	p.G179fs	SLC25A48_ENST00000425402.1_Intron|SLC25A48_ENST00000433282.2_Frame_Shift_Ins_p.G125fs|SLC25A48_ENST00000412661.2_Intron|SLC25A48_ENST00000420621.1_Frame_Shift_Ins_p.G179fs			Q6ZT89	S2548_HUMAN	solute carrier family 25, member 48	179					transmembrane transport	integral to membrane|mitochondrial inner membrane	binding			NS(1)|breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(2)|lung(3)|skin(1)	10						GGGGCTATACCGGGGGGCCAGT	0.604													7	448	---	---	---	---					
PSD2	84249	broad.mit.edu	37	5	139193287	139193288	+	Frame_Shift_Ins	INS	-	-	G			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr5:139193287_139193288insG	ENST00000274710.3	+	3	970_971	c.765_766insG	c.(763-768)ccggggfs	p.PG255fs		NM_032289.2	NP_115665.1	Q9BQI7	PSD2_HUMAN	pleckstrin and Sec7 domain containing 2	255					regulation of ARF protein signal transduction	cytoplasm|integral to membrane	ARF guanyl-nucleotide exchange factor activity			breast(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(10)|liver(2)|lung(15)|ovary(1)|prostate(2)	38			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTCAGGGCCCAGGGGGGGATGA	0.614													8	216	---	---	---	---					
ARAP3	64411	broad.mit.edu	37	5	141049341	141049342	+	Frame_Shift_Ins	INS	-	-	C			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr5:141049341_141049342insC	ENST00000239440.4	-	16	2351_2352	c.2286_2287insG	c.(2284-2289)ggggatfs	p.D763fs	ARAP3_ENST00000508305.1_Frame_Shift_Ins_p.D665fs|ARAP3_ENST00000513878.1_Frame_Shift_Ins_p.D425fs	NM_022481.5	NP_071926.4	Q8WWN8	ARAP3_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3	763					cytoskeleton organization|negative regulation of cell migration|negative regulation of Rho protein signal transduction|regulation of ARF GTPase activity|regulation of cell shape|small GTPase mediated signal transduction|vesicle-mediated transport	cytoskeleton|cytosol|lamellipodium|plasma membrane|ruffle	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|Rho GTPase activator activity|zinc ion binding			NS(1)|breast(7)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|lung(14)|ovary(1)|prostate(2)|skin(4)|stomach(1)	53						TGCTGGATCCTCCCCCCAGCGA	0.579													10	748	---	---	---	---					
PCDH12	51294	broad.mit.edu	37	5	141336747	141336748	+	Frame_Shift_Ins	INS	-	-	G			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr5:141336747_141336748insG	ENST00000231484.3	-	1	1879_1880	c.669_670insC	c.(667-672)ccagtcfs	p.V224fs		NM_016580.2	NP_057664.1	Q9NPG4	PCD12_HUMAN	protocadherin 12	224	Cadherin 2.				neuron recognition	integral to plasma membrane	calcium ion binding			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|lung(14)|ovary(3)|prostate(2)|skin(1)	38		all_hematologic(541;0.0999)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GTACCTGACTTGGGGGGGTTCC	0.480													9	339	---	---	---	---					
PPP2R2B	5521	broad.mit.edu	37	5	145969651	145969652	+	Frame_Shift_Ins	INS	-	-	C			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr5:145969651_145969652insC	ENST00000394413.3	-	9	1760_1761	c.1190_1191insG	c.(1189-1191)gaafs	p.E397fs	PPP2R2B_ENST00000394410.2_Frame_Shift_Ins_p.E386fs|PPP2R2B_ENST00000336640.6_Frame_Shift_Ins_p.E400fs|CTB-99A3.1_ENST00000512730.1_RNA|PPP2R2B_ENST00000394411.4_Frame_Shift_Ins_p.E397fs|PPP2R2B_ENST00000394409.3_Frame_Shift_Ins_p.E455fs|PPP2R2B_ENST00000530902.1_5'UTR|PPP2R2B_ENST00000508545.2_Frame_Shift_Ins_p.E386fs|PPP2R2B_ENST00000453001.1_Frame_Shift_Ins_p.E397fs|PPP2R2B_ENST00000504198.1_Frame_Shift_Ins_p.E403fs|PPP2R2B_ENST00000394414.1_Frame_Shift_Ins_p.E463fs|PPP2R2B_ENST00000356826.3_Frame_Shift_Ins_p.E397fs			Q00005	2ABB_HUMAN	protein phosphatase 2, regulatory subunit B, beta	397					apoptosis|signal transduction	cytoskeleton|mitochondrial outer membrane|protein phosphatase type 2A complex	protein binding|protein phosphatase type 2A regulator activity			endometrium(3)|kidney(4)|large_intestine(6)|liver(2)|lung(9)|ovary(1)|prostate(4)|skin(3)	32			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			TTCTCCGCTTGCCCCCCACACA	0.500													7	719	---	---	---	---					
GALNT10	55568	broad.mit.edu	37	5	153789314	153789315	+	Frame_Shift_Ins	INS	-	-	G			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr5:153789314_153789315insG	ENST00000297107.6	+	9	1515_1516	c.1378_1379insG	c.(1378-1380)gggfs	p.G460fs	GALNT10_ENST00000377661.2_Frame_Shift_Ins_p.G398fs|SAP30L-AS1_ENST00000524264.1_RNA|SAP30L-AS1_ENST00000519727.1_RNA|GALNT10_ENST00000377657.3_Frame_Shift_Ins_p.G133fs	NM_198321.3	NP_938080.1	Q86SR1	GLT10_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 10 (GalNAc-T10)	460	Ricin B-type lectin.					Golgi membrane|integral to membrane	metal ion binding|polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(12)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	32	Renal(175;0.00488)	Medulloblastoma(196;0.0354)|all_neural(177;0.147)|all_hematologic(541;0.21)	Kidney(363;8.21e-05)|KIRC - Kidney renal clear cell carcinoma(527;0.000577)			GGCTGCAGCTTGGGGGGAGGTG	0.535													7	185	---	---	---	---					
LARP1	23367	broad.mit.edu	37	5	154181821	154181822	+	Frame_Shift_Ins	INS	-	-	G			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr5:154181821_154181822insG	ENST00000336314.4	+	11	1764_1765	c.1740_1741insG	c.(1738-1743)ccggggfs	p.PG580fs		NM_015315.3	NP_056130.2	Q6PKG0	LARP1_HUMAN	La ribonucleoprotein domain family, member 1	657							protein binding|RNA binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(10)|lung(9)|ovary(3)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	33	Renal(175;0.00488)	Medulloblastoma(196;0.0354)|all_neural(177;0.147)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)			GCCGGCACCCAGGGGGGGACCG	0.550													13	303	---	---	---	---					
GCNT2	2651	broad.mit.edu	37	6	10557409	10557410	+	Frame_Shift_Ins	INS	-	-	C	rs55808116		TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr6:10557409_10557410insC	ENST00000316170.3	+	1	1170_1171	c.753_754insC	c.(751-756)ccccccfs	p.PP251fs	GCNT2_ENST00000410107.1_Intron|GCNT2_ENST00000495262.1_Intron|GCNT2_ENST00000379597.3_Intron|GCNT2_ENST00000397423.2_Intron	NM_001491.2	NP_001482.1	Q8N0V5	GNT2A_HUMAN	glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)	253						Golgi membrane|integral to membrane	N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity			endometrium(2)|kidney(1)|large_intestine(5)|lung(2)|ovary(2)	12	Ovarian(93;0.107)|Breast(50;0.148)	all_hematologic(90;0.107)		KIRC - Kidney renal clear cell carcinoma(1;0.099)|Kidney(1;0.119)		TGAAACCGCCTCCCCCCCATAA	0.485													23	446	---	---	---	---					
PHACTR1	221692	broad.mit.edu	37	6	13206134	13206135	+	Frame_Shift_Ins	INS	-	-	G			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr6:13206134_13206135insG	ENST00000379350.1	+	7	881_882	c.752_753insG	c.(751-753)gggfs	p.G251fs	PHACTR1_ENST00000379345.2_Intron|PHACTR1_ENST00000457702.2_Frame_Shift_Ins_p.G106fs|PHACTR1_ENST00000332995.7_Frame_Shift_Ins_p.G251fs			Q9C0D0	PHAR1_HUMAN	phosphatase and actin regulator 1	251						cell junction|cytoplasm|synapse	actin binding|protein phosphatase inhibitor activity			breast(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(10)|ovary(1)|skin(2)|upper_aerodigestive_tract(3)	26	Breast(50;0.0427)|Ovarian(93;0.12)	all_hematologic(90;0.122)|Lung SC(78;0.195)	Epithelial(50;0.146)|BRCA - Breast invasive adenocarcinoma(129;0.239)			TGTATGCCCGTGGGGGGGCCAG	0.599													12	340	---	---	---	---					
DCDC2	51473	broad.mit.edu	37	6	24205282	24205283	+	Frame_Shift_Ins	INS	-	-	C			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr6:24205282_24205283insC	ENST00000378454.3	-	8	1271_1272	c.970_971insG	c.(970-972)agcfs	p.S324fs	DCDC2_ENST00000378450.3_Frame_Shift_Ins_p.S77fs	NM_001195610.1|NM_016356.3	NP_001182539.1|NP_057440.2	Q9UHG0	DCDC2_HUMAN	doublecortin domain containing 2	324					cellular defense response|intracellular signal transduction|neuron migration					breast(1)|endometrium(2)|kidney(3)|large_intestine(8)|lung(12)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	32		Ovarian(999;0.101)				GACTTCTGCTGCCCCCCGTGTT	0.411													19	1515	---	---	---	---					
ZKSCAN3	80317	broad.mit.edu	37	6	28334004	28334004	+	Frame_Shift_Del	DEL	T	T	-			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr6:28334004delT	ENST00000377255.3	+	7	1856	c.1559delT	c.(1558-1560)atfs	p.I520fs	ZKSCAN3_ENST00000252211.2_Frame_Shift_Del_p.I520fs|ZKSCAN3_ENST00000341464.5_Frame_Shift_Del_p.I372fs	NM_001242894.1	NP_001229823.1	Q9BRR0	ZKSC3_HUMAN	zinc finger with KRAB and SCAN domains 3	520					positive regulation of transcription, DNA-dependent|viral reproduction	nucleus	chromatin binding|DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			kidney(4)|large_intestine(3)|lung(8)|pancreas(1)|skin(2)|stomach(2)|urinary_tract(1)	21						TTCACCCGAATTTCATACCTT	0.433													126	202	---	---	---	---					
MOG	4340	broad.mit.edu	37	6	29627216	29627217	+	Frame_Shift_Ins	INS	-	-	C			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr6:29627216_29627217insC	ENST00000376894.4	+	2	327_328	c.209_210insC	c.(208-210)cccfs	p.P70fs	MOG_ENST00000396704.3_Frame_Shift_Ins_p.P70fs|MOG_ENST00000483013.1_Intron|MOG_ENST00000376917.3_Frame_Shift_Ins_p.P70fs|MOG_ENST00000376888.2_Intron|MOG_ENST00000396701.2_Frame_Shift_Ins_p.P70fs|MOG_ENST00000494692.1_Frame_Shift_Ins_p.P70fs|MOG_ENST00000376898.3_Frame_Shift_Ins_p.P70fs|MOG_ENST00000376891.4_Frame_Shift_Ins_p.P70fs|MOG_ENST00000376902.3_Frame_Shift_Ins_p.P70fs|MOG_ENST00000533330.2_Frame_Shift_Ins_p.P70fs|MOG_ENST00000416766.2_Frame_Shift_Ins_p.P70fs|MOG_ENST00000469603.1_3'UTR|MOG_ENST00000490427.1_Intron|MOG_ENST00000431798.2_Frame_Shift_Ins_p.P70fs			Q16653	MOG_HUMAN	myelin oligodendrocyte glycoprotein	70	Ig-like V-type.				cell adhesion|central nervous system development|positive regulation of MyD88-dependent toll-like receptor signaling pathway	integral to membrane|plasma membrane		p.F73fs*29(1)		endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(8)|ovary(1)|skin(2)	19						GGGTGGTACCGCCCCCCCTTCT	0.569													16	362	---	---	---	---					
ATAT1	79969	broad.mit.edu	37	6	30610713	30610714	+	Frame_Shift_Ins	INS	-	-	C			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr6:30610713_30610714insC	ENST00000376483.4	+	10	903_904	c.893_894insC	c.(892-894)tccfs	p.S298fs	ATAT1_ENST00000376478.2_Frame_Shift_Ins_p.S275fs|ATAT1_ENST00000329992.8_Frame_Shift_Ins_p.S298fs|ATAT1_ENST00000376485.4_Frame_Shift_Ins_p.S298fs|ATAT1_ENST00000330083.5_Frame_Shift_Ins_p.S286fs|ATAT1_ENST00000318999.7_Frame_Shift_Ins_p.S275fs|ATAT1_ENST00000319027.5_Frame_Shift_Ins_p.S275fs|ATAT1_ENST00000468713.1_Intron			Q5SQI0	ATAT_HUMAN	alpha tubulin acetyltransferase 1	298							tubulin N-acetyltransferase activity			cervix(1)|endometrium(1)|large_intestine(1)|lung(1)|ovary(3)|prostate(1)|upper_aerodigestive_tract(1)	9						TTGCGCCTCTGCCCCCCACACC	0.658													7	605	---	---	---	---					
BAG6	7917	broad.mit.edu	37	6	31608570	31608571	+	Splice_Site	INS	-	-	G			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr6:31608570_31608571insG	ENST00000404765.2	-	21	3221_3222	c.2934_splice	c.e21+1	p.A978_splice	BAG6_ENST00000362049.6_Splice_Site_p.A942_splice|BAG6_ENST00000211379.5_Splice_Site_p.A942_splice|BAG6_ENST00000375964.6_Splice_Site_p.A948_splice|BAG6_ENST00000439687.2_Splice_Site_p.A816_splice|BAG6_ENST00000375976.4_Splice_Site_p.A942_splice			P46379	BAG6_HUMAN	BCL2-associated athanogene 6	948					apoptosis in response to endoplasmic reticulum stress|brain development|cell differentiation|chromatin modification|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|embryo development|internal peptidyl-lysine acetylation|kidney development|lung development|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|protein stabilization|spermatogenesis|synaptonemal complex assembly|tail-anchored membrane protein insertion into ER membrane|transport|ubiquitin-dependent protein catabolic process	BAT3 complex|nucleus	polyubiquitin binding|proteasome binding|ribosome binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(18)|ovary(2)|pancreas(2)|skin(3)|urinary_tract(2)	36						GTCCCTTACCTGGGGGGGATCA	0.535													7	296	---	---	---	---					
BAG6	7917	broad.mit.edu	37	6	31608920	31608921	+	Frame_Shift_Ins	INS	-	-	C			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr6:31608920_31608921insC	ENST00000404765.2	-	20	3036_3037	c.2747_2748insG	c.(2746-2748)gcafs	p.A916fs	BAG6_ENST00000362049.6_Frame_Shift_Ins_p.A880fs|BAG6_ENST00000211379.5_Frame_Shift_Ins_p.A880fs|BAG6_ENST00000375964.6_Frame_Shift_Ins_p.A886fs|BAG6_ENST00000439687.2_Frame_Shift_Ins_p.A754fs|BAG6_ENST00000375976.4_Frame_Shift_Ins_p.A880fs			P46379	BAG6_HUMAN	BCL2-associated athanogene 6	886					apoptosis in response to endoplasmic reticulum stress|brain development|cell differentiation|chromatin modification|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|embryo development|internal peptidyl-lysine acetylation|kidney development|lung development|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|protein stabilization|spermatogenesis|synaptonemal complex assembly|tail-anchored membrane protein insertion into ER membrane|transport|ubiquitin-dependent protein catabolic process	BAT3 complex|nucleus	polyubiquitin binding|proteasome binding|ribosome binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(18)|ovary(2)|pancreas(2)|skin(3)|urinary_tract(2)	36						CCATCTGCTGTCCCCCCAAGCA	0.515													11	496	---	---	---	---					
C6orf25	80739	broad.mit.edu	37	6	31692528	31692529	+	Frame_Shift_Ins	INS	-	-	C			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr6:31692528_31692529insC	ENST00000375809.3	+	5	558_559	c.547_548insC	c.(547-549)cccfs	p.P183fs	C6orf25_ENST00000375805.2_Frame_Shift_Ins_p.CP152fs|C6orf25_ENST00000375810.4_Frame_Shift_Ins_p.P183fs|C6orf25_ENST00000480039.1_Intron	NM_025260.3|NM_138272.2|NM_138277.2	NP_079536.2|NP_612116.1|NP_612121.1	O95866	G6B_HUMAN	chromosome 6 open reading frame 25	0						endoplasmic reticulum|Golgi apparatus|integral to membrane|plasma membrane	heparin binding|receptor activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(3)	9						TTCAGCTCTGTCCCCCCCACAT	0.579													8	517	---	---	---	---					
FANCE	2178	broad.mit.edu	37	6	35425714	35425715	+	Frame_Shift_Ins	INS	-	-	C			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr6:35425714_35425715insC	ENST00000229769.2	+	4	1107_1108	c.922_923insC	c.(922-924)cccfs	p.P308fs		NM_021922.2	NP_068741.1	Q9HB96	FANCE_HUMAN	Fanconi anemia, complementation group E	308	Interaction with FANCC.				DNA repair	nucleoplasm	protein binding			NS(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(3)|ovary(1)|skin(2)	13						ATTGGAGGATGCCCCCCCAGTT	0.540			"""N, F, S"""			"""AML, leukemia"""		Involved in tolerance or repair of DNA crosslinks	Fanconi Anemia				19	379	---	---	---	---					
BRPF3	27154	broad.mit.edu	37	6	36196737	36196738	+	Frame_Shift_Ins	INS	-	-	C			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr6:36196737_36196738insC	ENST00000357641.6	+	12	3591_3592	c.3338_3339insC	c.(3337-3339)gccfs	p.A1113fs	BRPF3_ENST00000543502.1_Frame_Shift_Ins_p.A843fs|BRPF3_ENST00000339717.7_Frame_Shift_Ins_p.A843fs|BRPF3_ENST00000534400.1_Frame_Shift_Ins_p.CP1080fs|BRPF3_ENST00000534694.1_Frame_Shift_Ins_p.A779fs|BRPF3_ENST00000443324.2_Frame_Shift_Ins_p.A779fs	NM_015695.2	NP_056510.2	Q9ULD4	BRPF3_HUMAN	bromodomain and PHD finger containing, 3	1113	PWWP.				histone H3 acetylation|platelet activation|platelet degranulation	cytosol|extracellular region|MOZ/MORF histone acetyltransferase complex	protein binding|zinc ion binding			breast(1)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(8)|lung(15)|ovary(1)|prostate(1)|skin(4)|urinary_tract(2)	40						CCCATCCCTGTCCCCCCGCTGG	0.584													8	463	---	---	---	---					
TNFRSF21	27242	broad.mit.edu	37	6	47253988	47253989	+	Frame_Shift_Ins	INS	-	-	G			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr6:47253988_47253989insG	ENST00000296861.2	-	2	832_833	c.439_440insC	c.(439-441)tacfs	p.Y147fs		NM_014452.3	NP_055267.1	O75509	TNR21_HUMAN	tumor necrosis factor receptor superfamily, member 21	147					cellular lipid metabolic process	cytoplasm|integral to membrane	protein binding|receptor activity			breast(1)|central_nervous_system(1)|endometrium(3)|large_intestine(6)|lung(7)|pancreas(1)|skin(2)	21			Lung(136;0.189)			ACACACCGTATGGGGGGCACAG	0.554													7	749	---	---	---	---					
HCRTR2	3062	broad.mit.edu	37	6	55039410	55039411	+	Frame_Shift_Ins	INS	-	-	C	rs76774128		TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr6:55039410_55039411insC	ENST00000370862.3	+	1	361_362	c.25_26insC	c.(25-27)cccfs	p.P9fs		NM_001526.3	NP_001517.2	O43614	OX2R_HUMAN	hypocretin (orexin) receptor 2	9					feeding behavior	integral to plasma membrane	neuropeptide receptor activity	p.P11fs*11(1)		breast(3)|endometrium(2)|kidney(1)|large_intestine(7)|lung(23)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	46	Lung NSC(77;0.107)|Renal(3;0.122)		LUSC - Lung squamous cell carcinoma(124;0.23)			ATTGGAGGACTCCCCCCCTTGT	0.564													10	234	---	---	---	---					
HTR1E	3354	broad.mit.edu	37	6	87725846	87725847	+	Frame_Shift_Ins	INS	-	-	C			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr6:87725846_87725847insC	ENST00000305344.4	+	2	1497_1498	c.794_795insC	c.(793-795)accfs	p.T265fs	HTR1E_ENST00000369584.1_Frame_Shift_Ins_p.T265fs	NM_000865.2	NP_000856.1	P28566	5HT1E_HUMAN	5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled	265					G-protein signaling, coupled to cyclic nucleotide second messenger|synaptic transmission	integral to plasma membrane	protein binding|serotonin binding|serotonin receptor activity	p.F268fs*4(1)		breast(3)|endometrium(2)|kidney(3)|large_intestine(11)|lung(15)|ovary(2)|prostate(2)|skin(3)	41		all_cancers(76;7.11e-06)|Acute lymphoblastic leukemia(125;1.2e-09)|Prostate(29;3.51e-09)|all_hematologic(105;7.43e-06)|all_epithelial(107;0.00819)		BRCA - Breast invasive adenocarcinoma(108;0.055)	Eletriptan(DB00216)	TCCATCAGGATCCCCCCCTTCG	0.510													23	740	---	---	---	---					
AIM1	202	broad.mit.edu	37	6	107011654	107011655	+	Frame_Shift_Del	DEL	TG	TG	-			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr6:107011654_107011655delTG	ENST00000369066.3	+	19	5417_5418	c.4930_4931delTG	c.(4930-4932)cfs	p.C1644fs	AIM1_ENST00000535438.1_Frame_Shift_Del_p.C463fs	NM_001624.2	NP_001615.1	Q9Y4K1	AIM1_HUMAN	absent in melanoma 1	1644	Ricin B-type lectin.						sugar binding			breast(8)|central_nervous_system(1)|cervix(2)|endometrium(6)|kidney(7)|large_intestine(13)|lung(20)|ovary(5)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	69	Breast(9;0.0138)|all_epithelial(6;0.169)	all_cancers(87;4.67e-25)|all_epithelial(87;5.46e-21)|Acute lymphoblastic leukemia(125;2.15e-07)|all_hematologic(75;5.28e-06)|Colorectal(196;3.46e-05)|all_lung(197;5.94e-05)|Lung NSC(302;7.26e-05)|Ovarian(999;0.00473)	Epithelial(6;0.00114)|all cancers(7;0.00726)|BRCA - Breast invasive adenocarcinoma(8;0.0114)|OV - Ovarian serous cystadenocarcinoma(5;0.0305)	all cancers(137;1.73e-50)|Epithelial(106;2.42e-48)|OV - Ovarian serous cystadenocarcinoma(136;1.51e-27)|BRCA - Breast invasive adenocarcinoma(108;0.00104)|GBM - Glioblastoma multiforme(226;0.00858)		AGAAGACTGCTGCCTGACGATT	0.490													46	150	---	---	---	---					
SCML4	256380	broad.mit.edu	37	6	108076790	108076791	+	Frame_Shift_Ins	INS	-	-	G	rs75302347		TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr6:108076790_108076791insG	ENST00000369021.3	-	1	52_53	c.53_54insC	c.(52-54)cttfs	p.L18fs	SCML4_ENST00000369020.3_Intron|SCML4_ENST00000369022.2_Intron			Q8N228	SCML4_HUMAN	sex comb on midleg-like 4 (Drosophila)	50					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			endometrium(2)|large_intestine(7)|lung(11)|ovary(3)|prostate(1)|skin(1)	25		all_cancers(87;3.26e-06)|Acute lymphoblastic leukemia(125;3.08e-08)|all_hematologic(75;1.15e-06)|all_epithelial(87;0.00142)|Colorectal(196;0.0316)		BRCA - Breast invasive adenocarcinoma(108;0.01)|Epithelial(106;0.0509)|all cancers(137;0.0586)|OV - Ovarian serous cystadenocarcinoma(136;0.0758)		TCCAGTGGAATGGGGGGGTTCT	0.480													7	259	---	---	---	---					
KIAA1919	91749	broad.mit.edu	37	6	111587105	111587106	+	Frame_Shift_Ins	INS	-	-	G			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr6:111587105_111587106insG	ENST00000368847.4	+	4	693_694	c.340_341insG	c.(340-342)gggfs	p.G114fs		NM_153369.2	NP_699200.2	Q5TF39	NAGT1_HUMAN	KIAA1919	114					carbohydrate transport|sodium ion transport	apical plasma membrane|integral to membrane	symporter activity			large_intestine(3)|lung(2)|ovary(4)|skin(3)	12		all_cancers(87;2.35e-05)|Acute lymphoblastic leukemia(125;2.13e-07)|all_hematologic(75;5.28e-06)|all_epithelial(87;0.00138)|Colorectal(196;0.0209)		OV - Ovarian serous cystadenocarcinoma(136;0.055)|all cancers(137;0.0871)|Epithelial(106;0.0884)		CTTGGCTATTTGGGGGGACAAA	0.416													7	185	---	---	---	---					
KIAA0408	9729	broad.mit.edu	37	6	127767595	127767596	+	Frame_Shift_Ins	INS	-	-	C			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr6:127767595_127767596insC	ENST00000483725.3	-	5	2204_2205	c.1868_1869insG	c.(1867-1869)gcafs	p.A623fs	SOGA3_ENST00000481848.2_3'UTR|SOGA3_ENST00000556132.1_3'UTR	NM_014702.4	NP_055517.3	Q6ZU52	K0408_HUMAN	KIAA0408	623							protein binding			endometrium(3)|large_intestine(7)|lung(15)|ovary(1)|pancreas(1)|skin(1)	28				GBM - Glioblastoma multiforme(226;0.0217)|all cancers(137;0.13)		TCACTTCCTGTCCCCCCCACAC	0.401													10	488	---	---	---	---					
UST	10090	broad.mit.edu	37	6	149395141	149395142	+	Frame_Shift_Ins	INS	-	-	C			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr6:149395141_149395142insC	ENST00000367463.4	+	8	1213_1214	c.1110_1111insC	c.(1108-1113)aaccccfs	p.NP370fs	UST_ENST00000466695.1_3'UTR	NM_005715.2	NP_005706.1	Q9Y2C2	UST_HUMAN	uronyl-2-sulfotransferase	370					protein sulfation	Golgi membrane|integral to membrane	sulfotransferase activity			breast(1)|endometrium(3)|large_intestine(4)|lung(2)|ovary(2)	12		Ovarian(120;0.0907)		OV - Ovarian serous cystadenocarcinoma(155;1.78e-10)|GBM - Glioblastoma multiforme(68;0.138)		ACGTCAGCAAGCCCCCCCTGAG	0.490													7	235	---	---	---	---					
NOX3	50508	broad.mit.edu	37	6	155750039	155750040	+	Frame_Shift_Ins	INS	-	-	G	rs79326507	byFrequency	TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr6:155750039_155750040insG	ENST00000159060.2	-	9	1135_1136	c.1033_1034insC	c.(1033-1035)ggafs	p.G345fs		NM_015718.2	NP_056533.1	Q9HBY0	NOX3_HUMAN	NADPH oxidase 3	345	FAD-binding FR-type.						electron carrier activity|flavin adenine dinucleotide binding|iron ion binding			cervix(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(16)|ovary(1)|pancreas(1)|prostate(4)|upper_aerodigestive_tract(1)	45		Breast(66;0.0183)		OV - Ovarian serous cystadenocarcinoma(155;2.18e-12)|BRCA - Breast invasive adenocarcinoma(81;0.00815)		AAAGTCCTCCTGGGGGGCAGAG	0.614													8	226	---	---	---	---					
NUPL2	11097	broad.mit.edu	37	7	23224772	23224773	+	Frame_Shift_Ins	INS	-	-	G			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr7:23224772_23224773insG	ENST00000258742.5	+	2	464_465	c.205_206insG	c.(205-207)gggfs	p.G69fs	AC005082.1_ENST00000366347.4_Intron|NUPL2_ENST00000487595.1_3'UTR|NUPL2_ENST00000410002.3_Frame_Shift_Ins_p.G69fs	NM_007342.2	NP_031368.1	O15504	NUPL2_HUMAN	nucleoporin like 2	69					carbohydrate metabolic process|glucose transport|mRNA transport|protein export from nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear membrane|nuclear pore	nuclear export signal receptor activity|nucleic acid binding|zinc ion binding			breast(1)|endometrium(1)|kidney(3)|large_intestine(3)|lung(4)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	19						ATCCACACCATGGGGGGGCAGC	0.406													10	166	---	---	---	---					
FKBP9	11328	broad.mit.edu	37	7	33014803	33014804	+	Frame_Shift_Ins	INS	-	-	C			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr7:33014803_33014804insC	ENST00000242209.4	+	3	546_547	c.377_378insC	c.(376-378)accfs	p.T126fs	FKBP9_ENST00000538336.1_Frame_Shift_Ins_p.T179fs|AVL9_ENST00000404479.1_Intron|FKBP9_ENST00000538443.1_5'UTR	NM_007270.3	NP_009201.2	O95302	FKBP9_HUMAN	FK506 binding protein 9, 63 kDa	126	PPIase FKBP-type 1.				protein folding	endoplasmic reticulum|membrane	calcium ion binding|FK506 binding|peptidyl-prolyl cis-trans isomerase activity			central_nervous_system(13)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(6)|lung(9)|ovary(2)|upper_aerodigestive_tract(1)	39			GBM - Glioblastoma multiforme(11;0.0156)			GCTGGTGTGATCCCCCCCAATT	0.446													14	316	---	---	---	---					
TRIM4	89122	broad.mit.edu	37	7	99489838	99489839	+	Frame_Shift_Ins	INS	-	-	A			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr7:99489838_99489839insA	ENST00000355947.2	-	7	1579_1580	c.1450_1451insT	c.(1450-1452)gttfs	p.V484fs	TRIM4_ENST00000349062.2_Frame_Shift_Ins_p.V458fs	NM_033017.3	NP_148977.2	Q9C037	TRIM4_HUMAN	tripartite motif containing 4	484	B30.2/SPRY.				protein trimerization	cytoplasm|plasma membrane	zinc ion binding			breast(2)|endometrium(1)|kidney(1)|large_intestine(3)|lung(8)|ovary(1)|skin(1)	17	Esophageal squamous(72;0.0166)|Lung NSC(181;0.0211)|all_lung(186;0.0323)	Ovarian(593;0.238)				TGGACTCAACCAAAAAAATGGC	0.505													9	505	---	---	---	---					
SPDYE3	441272	broad.mit.edu	37	7	99912173	99912174	+	Frame_Shift_Ins	INS	-	-	C			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr7:99912173_99912174insC	ENST00000332397.6	+	6	1185_1186	c.1001_1002insC	c.(1000-1002)accfs	p.T334fs	SPDYE3_ENST00000437326.2_5'UTR	NM_001004351.4	NP_001004351.3	A6NKU9	SPDE3_HUMAN	speedy/RINGO cell cycle regulator family member E3	334										endometrium(10)|kidney(1)|lung(8)|urinary_tract(1)	20						GTAGATCCCAGCCCCCCGCGTA	0.569													27	870	---	---	---	---					
ZCWPW1	55063	broad.mit.edu	37	7	100004397	100004398	+	Frame_Shift_Ins	INS	-	-	A			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr7:100004397_100004398insA	ENST00000398027.2	-	12	1336_1337	c.1089_1090insT	c.(1087-1092)ttgagafs	p.LR363fs	ZCWPW1_ENST00000490721.1_Frame_Shift_Ins_p.LR243fs|ZCWPW1_ENST00000360951.4_Frame_Shift_Ins_p.LR364fs|ZCWPW1_ENST00000324725.6_Frame_Shift_Ins_p.LR243fs	NM_017984.4	NP_060454.3	Q9H0M4	ZCPW1_HUMAN	zinc finger, CW type with PWWP domain 1	363	PWWP.						zinc ion binding			breast(1)|kidney(1)|large_intestine(5)|lung(6)|ovary(1)|prostate(1)|skin(1)	16	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					ACTGTTTCTCCAAAAAACGTCA	0.480													8	442	---	---	---	---					
AP1S1	1174	broad.mit.edu	37	7	100802404	100802405	+	Frame_Shift_Ins	INS	-	-	G			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr7:100802404_100802405insG	ENST00000337619.5	+	4	474_475	c.356_357insG	c.(355-357)aggfs	p.R119fs		NM_001283.3	NP_001274.1	P61966	AP1S1_HUMAN	adaptor-related protein complex 1, sigma 1 subunit	119					intracellular protein transport|post-Golgi vesicle-mediated transport|receptor-mediated endocytosis|regulation of defense response to virus by virus|response to virus|viral reproduction	AP-1 adaptor complex|coated pit|cytosol|lysosomal membrane	protein binding|protein transporter activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(2)	8	Lung NSC(181;0.168)|all_lung(186;0.215)					GAGTTTTTGATGGGGGGGGATG	0.564													8	148	---	---	---	---					
LAMB1	3912	broad.mit.edu	37	7	107572729	107572730	+	Frame_Shift_Ins	INS	-	-	C	rs57244800	byFrequency	TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr7:107572729_107572730insC	ENST00000393561.1	-	26	4537_4538	c.4353_4354insG	c.(4351-4356)ggctggfs	p.W1452fs	LAMB1_ENST00000474380.1_5'UTR|LAMB1_ENST00000222399.6_Frame_Shift_Ins_p.W1428fs			P07942	LAMB1_HUMAN	laminin, beta 1	1428	Domain I.				axon guidance|odontogenesis|positive regulation of cell migration|positive regulation of epithelial cell proliferation|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-2 complex|laminin-8 complex|perinuclear region of cytoplasm	extracellular matrix structural constituent			NS(3)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(4)|large_intestine(11)|lung(37)|ovary(6)|prostate(5)|skin(5)|upper_aerodigestive_tract(3)	82					Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	CCACAGCCAGGCCCCCCACACT	0.584													7	372	---	---	---	---					
KEL	3792	broad.mit.edu	37	7	142639979	142639980	+	Frame_Shift_Ins	INS	-	-	C	rs140258059		TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr7:142639979_142639980insC	ENST00000355265.2	-	17	2397_2398	c.1923_1924insG	c.(1921-1926)ggtagcfs	p.S642fs		NM_000420.2	NP_000411.1	P23276	KELL_HUMAN	Kell blood group, metallo-endopeptidase	642					proteolysis|vasoconstriction	integral to membrane|plasma membrane	metal ion binding|metalloendopeptidase activity|protein binding			central_nervous_system(1)|endometrium(3)|kidney(5)|large_intestine(11)|lung(34)|ovary(3)|prostate(2)|skin(1)	60	Melanoma(164;0.059)					GCGATGGCTAGCCCCCCAACGT	0.500													14	1025	---	---	---	---					
SLC18A1	6570	broad.mit.edu	37	8	20004787	20004788	+	Frame_Shift_Ins	INS	-	-	G			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr8:20004787_20004788insG	ENST00000440926.1	-	16	1915_1916	c.1445_1446insC	c.(1444-1446)cgcfs	p.R482fs	SLC18A1_ENST00000381608.4_Intron|SLC18A1_ENST00000519026.1_Frame_Shift_Ins_p.R450fs|SLC18A1_ENST00000276373.5_Frame_Shift_Ins_p.R482fs|SLC18A1_ENST00000437980.1_Intron|SLC18A1_ENST00000265808.7_Frame_Shift_Ins_p.R450fs	NM_001135691.2	NP_001129163.1	P54219	VMAT1_HUMAN	solute carrier family 18 (vesicular monoamine transporter), member 1	482					neurotransmitter transport	clathrin sculpted monoamine transport vesicle membrane|integral to membrane|membrane fraction	drug transmembrane transporter activity|monoamine transmembrane transporter activity			central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(10)|ovary(3)|prostate(1)|upper_aerodigestive_tract(1)	29				Colorectal(74;0.0747)		CTTCCTTTGCCGGGGGGCTCCG	0.500													7	328	---	---	---	---					
DPYSL2	1808	broad.mit.edu	37	8	26513183	26513184	+	Frame_Shift_Ins	INS	-	-	C			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr8:26513183_26513184insC	ENST00000311151.5	+	14	2092_2093	c.1680_1681insC	c.(1678-1683)gcccccfs	p.AP560fs	DPYSL2_ENST00000521913.1_Frame_Shift_Ins_p.AP524fs|DPYSL2_ENST00000523027.1_Frame_Shift_Ins_p.AP524fs	NM_001386.5	NP_001377.1	Q16555	DPYL2_HUMAN	dihydropyrimidinase-like 2	560					axon guidance|pyrimidine base catabolic process|signal transduction	cytosol	dihydropyrimidinase activity|protein binding			breast(1)|endometrium(5)|large_intestine(8)|lung(3)|prostate(1)|skin(1)|stomach(1)	20		all_cancers(63;0.121)|Ovarian(32;2.68e-05)|all_epithelial(46;0.116)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0228)|Epithelial(17;3.33e-10)|Colorectal(74;0.183)		GTATCGTGGCGCCCCCCGGTGG	0.644											OREG0018659	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	9	527	---	---	---	---					
ARFGEF1	10565	broad.mit.edu	37	8	68128855	68128856	+	Frame_Shift_Ins	INS	-	-	G	rs142098461		TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr8:68128855_68128856insG	ENST00000262215.3	-	33	5044_5045	c.4655_4656insC	c.(4654-4656)cccfs	p.P1552fs	ARFGEF1_ENST00000520381.1_Frame_Shift_Ins_p.P1006fs|ARFGEF1_ENST00000518230.1_Frame_Shift_Ins_p.P390fs	NM_006421.4	NP_006412.2	Q9Y6D6	BIG1_HUMAN	ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited)	1552					exocytosis|regulation of ARF protein signal transduction	cytoplasm	ARF guanyl-nucleotide exchange factor activity|myosin binding			breast(1)|endometrium(14)|kidney(4)|large_intestine(17)|lung(20)|ovary(4)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	65	Breast(64;0.214)	Lung NSC(129;0.0908)|all_lung(136;0.152)	Epithelial(68;0.0043)|OV - Ovarian serous cystadenocarcinoma(28;0.00578)|all cancers(69;0.0173)|BRCA - Breast invasive adenocarcinoma(89;0.206)			GAGATGGAGGTGGGGGGGCAGT	0.421													7	194	---	---	---	---					
KIAA0020	9933	broad.mit.edu	37	9	2827084	2827085	+	Frame_Shift_Ins	INS	-	-	G			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr9:2827084_2827085insG	ENST00000397885.2	-	10	1229_1230	c.1023_1024insC	c.(1021-1026)ccaactfs	p.T342fs		NM_014878.4	NP_055693.4	Q15397	K0020_HUMAN	KIAA0020	342	PUM-HD.					endoplasmic reticulum|nucleolus	RNA binding			NS(1)|breast(2)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(7)|lung(4)|ovary(1)	21				GBM - Glioblastoma multiforme(50;0.0319)		GATCTGAGTTTGGGGGGTGCAT	0.366													7	160	---	---	---	---					
RLN2	6019	broad.mit.edu	37	9	5304560	5304561	+	Frame_Shift_Ins	INS	-	-	A			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr9:5304560_5304561insA	ENST00000381627.3	-	1	408_409	c.20_21insT	c.(19-21)tcafs	p.S7fs	RLN2_ENST00000308420.3_Frame_Shift_Ins_p.S7fs	NM_134441.2	NP_604390.1	P04090	REL2_HUMAN	relaxin 2	7					female pregnancy	extracellular region	hormone activity			endometrium(2)|kidney(1)|large_intestine(2)|lung(6)	11	all_hematologic(13;0.137)	Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.0201)|Lung(218;0.0987)		CTAGCAGGTGGAAAAAAAACAG	0.535													7	315	---	---	---	---					
ADAMTSL1	92949	broad.mit.edu	37	9	18829842	18829843	+	Splice_Site	INS	-	-	C			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr9:18829842_18829843insC	ENST00000380548.4	+	23	4455_4456	c.4114_splice	c.e23-1	p.DP1372_splice	ADAMTSL1_ENST00000380545.5_Splice_Site_p.DP73_splice	NM_001040272.5	NP_001035362.3	Q8N6G6	ATL1_HUMAN	ADAMTS-like 1	1372						proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|liver(2)|lung(17)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	42				GBM - Glioblastoma multiforme(50;1.29e-17)		TTCTCACAGATCCCCCCCAAGT	0.564													8	215	---	---	---	---					
FAM219A	203259	broad.mit.edu	37	9	34401027	34401028	+	Frame_Shift_Ins	INS	-	-	G			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr9:34401027_34401028insG	ENST00000445726.1	-	6	798_799	c.492_493insC	c.(490-495)ccagtcfs	p.V165fs	FAM219A_ENST00000379080.1_Frame_Shift_Ins_p.V152fs|FAM219A_ENST00000297620.4_Frame_Shift_Ins_p.V148fs|FAM219A_ENST00000379087.1_Frame_Shift_Ins_p.V146fs|FAM219A_ENST00000379089.1_Frame_Shift_Ins_p.V163fs|FAM219A_ENST00000379084.1_Splice_Site_p.P147_splice|FAM219A_ENST00000379081.1_Frame_Shift_Ins_p.V136fs	NM_001184940.1|NM_001184941.1	NP_001171869.1|NP_001171870.1	Q8IW50	CI025_HUMAN	family with sequence similarity 219, member A	165																	TTCACGGACTTGGGGGGGATGA	0.644													7	129	---	---	---	---					
PIGO	84720	broad.mit.edu	37	9	35091522	35091523	+	Frame_Shift_Ins	INS	-	-	G	rs144233446		TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr9:35091522_35091523insG	ENST00000378617.3	-	7	2755_2756	c.2361_2362insC	c.(2359-2364)cccttcfs	p.F788fs	PIGO_ENST00000361778.2_Intron|PIGO_ENST00000298004.5_Intron|PIGO_ENST00000341666.3_Frame_Shift_Ins_p.F788fs	NM_032634.3	NP_116023.2	Q8TEQ8	PIGO_HUMAN	phosphatidylinositol glycan anchor biosynthesis, class O	788					C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane	transferase activity	p.T788fs*5(1)		endometrium(3)|kidney(2)|large_intestine(8)|lung(13)|ovary(3)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(3)	38			LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00778)			GCTTGAGAAGTGGGGGGGCCTG	0.604													17	299	---	---	---	---					
ANKRD19P	138649	broad.mit.edu	37	9	95649123	95649124	+	RNA	INS	-	-	C			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr9:95649123_95649124insC	ENST00000473204.1	+	0	2259																											GCAATCTAGCACCCCCCAAAAG	0.540													9	366	---	---	---	---					
MRPL50	54534	broad.mit.edu	37	9	104152774	104152775	+	Frame_Shift_Ins	INS	-	-	G			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr9:104152774_104152775insG	ENST00000374865.4	-	2	471_472	c.450_451insC	c.(448-453)ccatttfs	p.F151fs	MRPL50_ENST00000539624.1_Intron	NM_019051.2	NP_061924.1	Q8N5N7	RM50_HUMAN	mitochondrial ribosomal protein L50	151						mitochondrion|ribosome		p.P150P(1)		large_intestine(1)|lung(2)|prostate(2)	5		Acute lymphoblastic leukemia(62;0.0559)				ATTTTCAAATTGGGGGGCAGAT	0.401													8	358	---	---	---	---					
ABCA1	19	broad.mit.edu	37	9	107593322	107593323	+	Frame_Shift_Ins	INS	-	-	C			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr9:107593322_107593323insC	ENST00000374736.3	-	14	2169_2170	c.1775_1776insG	c.(1774-1776)gttfs	p.V592fs		NM_005502.3	NP_005493.2	O95477	ABCA1_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 1	592					Cdc42 protein signal transduction|cellular lipid metabolic process|cholesterol efflux|cholesterol homeostasis|cholesterol metabolic process|endosome transport|G-protein coupled receptor protein signaling pathway|high-density lipoprotein particle assembly|interleukin-1 beta secretion|intracellular cholesterol transport|lysosome organization|negative regulation of cholesterol storage|negative regulation of macrophage derived foam cell differentiation|phospholipid efflux|phospholipid homeostasis|platelet dense granule organization|positive regulation of cAMP biosynthetic process|reverse cholesterol transport	integral to plasma membrane|membrane fraction|membrane raft|phagocytic vesicle	anion transmembrane transporter activity|apolipoprotein A-I receptor activity|ATP binding|ATPase activity|cholesterol transporter activity|phospholipid transporter activity|small GTPase binding|syntaxin-13 binding			NS(1)|autonomic_ganglia(1)|breast(5)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(31)|liver(1)|lung(40)|ovary(5)|pancreas(2)|prostate(4)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	115				OV - Ovarian serous cystadenocarcinoma(323;0.023)	Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	AGTAGGCGAAGCCCCCCCAGAC	0.540													7	348	---	---	---	---					
PHYH	5264	broad.mit.edu	37	10	13325834	13325835	+	Frame_Shift_Ins	INS	-	-	C			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr10:13325834_13325835insC	ENST00000396920.3	-	7	1036_1037	c.632_633insG	c.(631-633)ggtfs	p.G211fs	PHYH_ENST00000396913.2_Frame_Shift_Ins_p.G128fs|PHYH_ENST00000263038.4_Frame_Shift_Ins_p.G228fs			O14832	PAHX_HUMAN	phytanoyl-CoA 2-hydroxylase	228					fatty acid alpha-oxidation|nervous system development	peroxisomal matrix	electron carrier activity|L-ascorbic acid binding|metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|phytanoyl-CoA dioxygenase activity|protein binding			NS(1)|endometrium(5)|kidney(2)|large_intestine(4)|lung(10)|pancreas(1)|prostate(2)	25		Ovarian(717;0.0448)			Antihemophilic Factor(DB00025)|Vitamin C(DB00126)	TTTTGTTAACTCCCCCCTAGAA	0.465													9	689	---	---	---	---					
FRMD4A	55691	broad.mit.edu	37	10	13696451	13696452	+	Frame_Shift_Ins	INS	-	-	G			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr10:13696451_13696452insG	ENST00000357447.2	-	23	3382_3383	c.3014_3015insC	c.(3013-3015)cagfs	p.Q1005fs	FRMD4A_ENST00000378503.1_Frame_Shift_Ins_p.Q1005fs|FRMD4A_ENST00000358621.4_Frame_Shift_Ins_p.Q990fs	NM_018027.3	NP_060497.3	Q9P2Q2	FRM4A_HUMAN	FERM domain containing 4A	1005	Ser-rich.					cytoplasm|cytoskeleton	binding			breast(4)|endometrium(9)|kidney(2)|large_intestine(11)|lung(9)|ovary(2)|pancreas(1)|prostate(2)|skin(1)	41						GGGGGCTGCTTGGGGGGGTGGC	0.535													9	244	---	---	---	---					
MLLT10	8028	broad.mit.edu	37	10	21962451	21962452	+	Frame_Shift_Ins	INS	-	-	G			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr10:21962451_21962452insG	ENST00000377072.3	+	11	1572_1573	c.1224_1225insG	c.(1222-1227)gaggggfs	p.EG408fs	MLLT10_ENST00000446906.2_Frame_Shift_Ins_p.EG408fs|MLLT10_ENST00000377059.3_Frame_Shift_Ins_p.EG408fs|MLLT10_ENST00000307729.7_Frame_Shift_Ins_p.EG408fs	NM_004641.3	NP_004632.1	P55197	AF10_HUMAN	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10	408	DNA-binding.				positive regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding	p.V411fs*3(1)		NS(1)|large_intestine(2)|lung(1)|skin(1)|upper_aerodigestive_tract(1)	6						GAAGCCAGGAAGGGGGGGTAAA	0.436			T	"""MLL, PICALM, CDK6"""	AL								17	509	---	---	---	---					
MYO3A	53904	broad.mit.edu	37	10	26312957	26312958	+	Frame_Shift_Ins	INS	-	-	C			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr10:26312957_26312958insC	ENST00000265944.5	+	9	904_905	c.738_739insC	c.(736-741)ccccccfs	p.PP246fs	MYO3A_ENST00000543632.1_Frame_Shift_Ins_p.PP246fs	NM_017433.4	NP_059129.3	Q8NEV4	MYO3A_HUMAN	myosin IIIA	246	Protein kinase.				protein autophosphorylation|response to stimulus|sensory perception of sound|visual perception	cytoplasm|filamentous actin|filopodium|myosin complex	actin binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|plus-end directed microfilament motor activity|protein serine/threonine kinase activity			NS(2)|breast(9)|central_nervous_system(3)|endometrium(9)|kidney(10)|large_intestine(28)|liver(1)|lung(46)|ovary(11)|pancreas(1)|prostate(6)|skin(11)|stomach(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	146						CTAGGAATCCACCCCCAAAACT	0.386													9	357	---	---	---	---					
ANKRD26	22852	broad.mit.edu	37	10	27322258	27322259	+	Frame_Shift_Ins	INS	-	-	T			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr10:27322258_27322259insT	ENST00000376087.4	-	25	3867_3868	c.3702_3703insA	c.(3700-3705)aaaatcfs	p.I1235fs	ANKRD26_ENST00000436985.2_Frame_Shift_Ins_p.I1251fs|ANKRD26_ENST00000376070.3_Frame_Shift_Ins_p.I792fs	NM_001256053.1|NM_014915.2	NP_001242982.1|NP_055730.2	Q9UPS8	ANR26_HUMAN	ankyrin repeat domain 26	1234						centrosome				breast(4)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(14)|lung(30)|ovary(1)|pancreas(1)|prostate(3)|skin(2)|urinary_tract(2)	70						GACATAGATTGTTTTTTTAGGG	0.322													7	350	---	---	---	---					
ZEB1	6935	broad.mit.edu	37	10	31809832	31809833	+	Frame_Shift_Ins	INS	-	-	G			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr10:31809832_31809833insG	ENST00000446923.2	+	7	1912_1913	c.1521_1522insG	c.(1519-1524)gaggggfs	p.EG507fs	ZEB1_ENST00000320985.10_Frame_Shift_Ins_p.EG523fs|ZEB1_ENST00000542815.3_Frame_Shift_Ins_p.EG456fs|ZEB1_ENST00000559858.1_3'UTR|ZEB1_ENST00000560721.2_Frame_Shift_Ins_p.EG503fs|ZEB1_ENST00000361642.5_Frame_Shift_Ins_p.EG524fs	NM_001128128.2|NM_001174094.1	NP_001121600.1|NP_001167565.1	P37275	ZEB1_HUMAN	zinc finger E-box binding homeobox 1	523					cell proliferation|immune response|negative regulation of transcription from RNA polymerase II promoter|positive regulation of neuron differentiation	cytoplasm	E-box binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity|zinc ion binding			NS(2)|breast(4)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(14)|lung(38)|ovary(3)|skin(6)|upper_aerodigestive_tract(4)	77		Prostate(175;0.0156)				AAAGCTTTGAAGGGGGGGTGAA	0.371													9	257	---	---	---	---					
ZNF248	57209	broad.mit.edu	37	10	38121236	38121237	+	Frame_Shift_Ins	INS	-	-	C	rs34731183		TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr10:38121236_38121237insC	ENST00000395867.3	-	6	1596_1597	c.1046_1047insG	c.(1045-1047)gaafs	p.E349fs	ZNF248_ENST00000374648.3_Intron|ZNF248_ENST00000357328.4_Frame_Shift_Ins_p.E349fs|ZNF248_ENST00000494133.1_Intron	NM_001267605.1|NM_001267606.1|NM_001267607.1|NM_021045.2	NP_001254534.1|NP_001254535.1|NP_001254536.1|NP_066383.1	Q8NDW4	ZN248_HUMAN	zinc finger protein 248	349					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|endometrium(2)|large_intestine(5)|lung(9)|ovary(2)|urinary_tract(1)	20						CATAAGACTTTCCCCCCATGTG	0.401													8	427	---	---	---	---					
FAM21B	55747	broad.mit.edu	37	10	47909192	47909193	+	Frame_Shift_Ins	INS	-	-	C			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr10:47909192_47909193insC	ENST00000358474.5	+	10	762_763	c.762_763insC	c.(760-765)acccccfs	p.TP254fs		NM_018232.1	NP_060702.1	Q5SNT6	FA21B_HUMAN	family with sequence similarity 21, member B	254					retrograde transport, endosome to Golgi	early endosome membrane|WASH complex				endometrium(1)|kidney(1)|large_intestine(2)|lung(3)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	10						ACTTATTCACACCCCCCAAGCT	0.515													14	506	---	---	---	---					
CDHR1	92211	broad.mit.edu	37	10	85972096	85972097	+	Frame_Shift_Ins	INS	-	-	C			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr10:85972096_85972097insC	ENST00000372117.3	+	15	1818_1819	c.1715_1716insC	c.(1714-1716)cccfs	p.P572fs	CDHR1_ENST00000440770.2_Frame_Shift_Ins_p.P276fs|CDHR1_ENST00000332904.3_Frame_Shift_Ins_p.P572fs	NM_033100.2	NP_149091.1	Q96JP9	CDHR1_HUMAN	cadherin-related family member 1	572	Cadherin 5.				homophilic cell adhesion		calcium ion binding|receptor activity			breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(6)|liver(1)|lung(21)|ovary(1)|prostate(1)|skin(1)	36						GTCAATGACCACCCCCCTCAGT	0.510													7	606	---	---	---	---					
CPN1	1369	broad.mit.edu	37	10	101816832	101816833	+	Frame_Shift_Ins	INS	-	-	G			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr10:101816832_101816833insG	ENST00000370418.3	-	6	1199_1200	c.948_949insC	c.(946-951)ccaagafs	p.R317fs		NM_001308.2	NP_001299.1	P15169	CBPN_HUMAN	carboxypeptidase N, polypeptide 1	317	Catalytic.				proteolysis	extracellular space	metallocarboxypeptidase activity|zinc ion binding			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(14)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	33		Colorectal(252;0.234)		Epithelial(162;4.77e-10)|all cancers(201;3.82e-08)		AACTCCTCTTCGGGGGGAAACT	0.470													10	830	---	---	---	---					
PPRC1	23082	broad.mit.edu	37	10	103901076	103901077	+	Frame_Shift_Ins	INS	-	-	C			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr10:103901076_103901077insC	ENST00000278070.2	+	5	2850_2851	c.2811_2812insC	c.(2809-2814)ctccccfs	p.LP937fs	PPRC1_ENST00000413464.2_Frame_Shift_Ins_p.LP937fs	NM_015062.3	NP_055877.3	Q5VV67	PPRC1_HUMAN	peroxisome proliferator-activated receptor gamma, coactivator-related 1	937	Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleotide binding|RNA binding			central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(5)|large_intestine(10)|lung(19)|ovary(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	56		Colorectal(252;0.122)		Epithelial(162;4.97e-08)|all cancers(201;8.99e-07)		ATCCTTGCCTGCCCCCCCCACC	0.604													8	71	---	---	---	---					
TRUB1	142940	broad.mit.edu	37	10	116730191	116730192	+	Frame_Shift_Ins	INS	-	-	C			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr10:116730191_116730192insC	ENST00000298746.3	+	5	649_650	c.588_589insC	c.(586-591)gtccccfs	p.VP196fs		NM_139169.4	NP_631908.1	Q8WWH5	TRUB1_HUMAN	TruB pseudouridine (psi) synthase family member 1	196					pseudouridine synthesis|tRNA processing		pseudouridine synthase activity|RNA binding			breast(2)|kidney(2)|large_intestine(1)|lung(5)|urinary_tract(2)	12		Colorectal(252;0.09)|Breast(234;0.174)|Lung NSC(174;0.245)		Epithelial(162;0.00879)|all cancers(201;0.0243)		TAATGCAAGTGCCCCCCCTGTA	0.317													10	219	---	---	---	---					
OR51E1	143503	broad.mit.edu	37	11	4674216	4674217	+	Frame_Shift_Ins	INS	-	-	G			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr11:4674216_4674217insG	ENST00000396952.5	+	2	1110_1111	c.460_461insG	c.(460-462)gggfs	p.G154fs	OR51E1_ENST00000530215.1_Intron	NM_152430.3	NP_689643.2	Q8TCB6	O51E1_HUMAN	olfactory receptor, family 51, subfamily E, member 1	153					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.A155fs*3(1)		NS(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(13)|ovary(1)|pancreas(1)|skin(1)|stomach(2)	30		Medulloblastoma(188;0.0025)|Breast(177;0.0101)|all_neural(188;0.0227)		Epithelial(150;7.37e-14)|GBM - Glioblastoma multiforme(2;2.85e-05)|BRCA - Breast invasive adenocarcinoma(625;0.00222)|LUSC - Lung squamous cell carcinoma(625;0.19)		TGCTGTGGTGCGGGGGGCTGCA	0.559													17	829	---	---	---	---					
EIF4G2	1982	broad.mit.edu	37	11	10820934	10820935	+	Frame_Shift_Ins	INS	-	-	G			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr11:10820934_10820935insG	ENST00000526148.1	-	20	2871_2872	c.2361_2362insC	c.(2359-2364)ccgcgafs	p.R788fs	EIF4G2_ENST00000525681.1_Frame_Shift_Ins_p.R788fs|EIF4G2_ENST00000396525.2_Frame_Shift_Ins_p.R750fs|RP11-685M7.5_ENST00000532365.1_RNA|EIF4G2_ENST00000339995.5_Frame_Shift_Ins_p.R788fs	NM_001172705.1	NP_001166176.1	P78344	IF4G2_HUMAN	eukaryotic translation initiation factor 4 gamma, 2	788	W2.				cell cycle arrest|cell death|regulation of translational initiation|RNA metabolic process	eukaryotic translation initiation factor 4F complex	protein binding|translation initiation factor activity	p.S788R(1)		NS(1)|breast(2)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(7)|lung(14)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(6)	43				all cancers(16;2.8e-07)|Epithelial(150;4.18e-07)|BRCA - Breast invasive adenocarcinoma(625;0.111)		GTTTCATCGCTGGGGGGGTTTA	0.406													10	149	---	---	---	---					
PAMR1	25891	broad.mit.edu	37	11	35513669	35513670	+	Frame_Shift_Ins	INS	-	-	C			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr11:35513669_35513670insC	ENST00000378880.2	-	3	747_748	c.302_303insG	c.(301-303)gacfs	p.D101fs	PAMR1_ENST00000534803.1_5'UTR|PAMR1_ENST00000278360.3_Frame_Shift_Ins_p.D101fs|PAMR1_ENST00000378878.3_Frame_Shift_Ins_p.D101fs|PAMR1_ENST00000532848.1_Frame_Shift_Ins_p.D61fs	NM_001001991.1	NP_001001991.1	Q6UXH9	PAMR1_HUMAN	peptidase domain containing associated with muscle regeneration 1	101					proteolysis	extracellular region	serine-type endopeptidase activity			breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(8)|ovary(3)|upper_aerodigestive_tract(1)	26						CATCCAAGGTACCCCCCCATGA	0.520													47	947	---	---	---	---					
LRP4	4038	broad.mit.edu	37	11	46880747	46880748	+	Frame_Shift_Ins	INS	-	-	C			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr11:46880747_46880748insC	ENST00000378623.1	-	38	5746_5747	c.5504_5505insG	c.(5503-5505)gctfs	p.A1835fs	LRP4-AS1_ENST00000502049.2_RNA|LRP4-AS1_ENST00000531719.1_RNA	NM_002334.3	NP_002325.2	O75096	LRP4_HUMAN	low density lipoprotein receptor-related protein 4	1835					endocytosis|negative regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	integral to membrane	calcium ion binding|receptor activity			breast(7)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(13)|lung(24)|ovary(3)|pancreas(2)|prostate(5)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)	70				Lung(87;0.159)		CCCGGAGGAGGCCCCCCCGTGA	0.564													8	175	---	---	---	---					
SLC43A3	29015	broad.mit.edu	37	11	57185234	57185235	+	Frame_Shift_Ins	INS	-	-	G			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr11:57185234_57185235insG	ENST00000395123.2	-	8	961_962	c.657_658insC	c.(655-660)ccactafs	p.L220fs	SLC43A3_ENST00000529554.1_Frame_Shift_Ins_p.L220fs|SLC43A3_ENST00000395124.1_Frame_Shift_Ins_p.L220fs|SLC43A3_ENST00000352187.1_Frame_Shift_Ins_p.L220fs|SLC43A3_ENST00000533524.1_Frame_Shift_Ins_p.L233fs|SLC43A3_ENST00000528098.1_5'UTR	NM_001278201.1|NM_014096.2	NP_001265130.1|NP_054815.2	Q8NBI5	S43A3_HUMAN	solute carrier family 43, member 3	220					transmembrane transport	integral to membrane				central_nervous_system(1)|endometrium(1)|large_intestine(10)|lung(4)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	27						TAGCTGTAGTTGGGGGGCAGTG	0.564													12	311	---	---	---	---					
TMX2	51075	broad.mit.edu	37	11	57505845	57505846	+	Frame_Shift_Ins	INS	-	-	C			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr11:57505845_57505846insC	ENST00000278422.4	+	4	396_397	c.384_385insC	c.(382-387)aaccccfs	p.NP128fs	TMX2-CTNND1_ENST00000528395.1_Intron|TMX2_ENST00000378312.4_Frame_Shift_Ins_p.NP90fs	NM_015959.3	NP_057043.1	Q9Y320	TMX2_HUMAN	thioredoxin-related transmembrane protein 2	128	Thioredoxin.				cell redox homeostasis	integral to membrane				NS(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(3)|prostate(1)|urinary_tract(2)	12						TGACGTGCAAACCCCCCCTATA	0.421													15	435	---	---	---	---					
CPSF7	79869	broad.mit.edu	37	11	61183884	61183885	+	Frame_Shift_Ins	INS	-	-	G			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr11:61183884_61183885insG	ENST00000340437.4	-	6	866_867	c.786_787insC	c.(784-789)ccgtgtfs	p.C263fs	CPSF7_ENST00000394888.4_Frame_Shift_Ins_p.C220fs|CPSF7_ENST00000448745.1_Frame_Shift_Ins_p.C211fs|CPSF7_ENST00000439958.3_Frame_Shift_Ins_p.C211fs	NM_024811.3	NP_079087.3	Q8N684	CPSF7_HUMAN	cleavage and polyadenylation specific factor 7, 59kDa	220	Pro-rich.				mRNA 3'-end processing|nuclear mRNA splicing, via spliceosome|protein tetramerization|termination of RNA polymerase II transcription	mRNA cleavage factor complex	nucleotide binding|protein binding|RNA binding			breast(3)|central_nervous_system(1)|cervix(2)|endometrium(1)|kidney(2)|large_intestine(5)|lung(5)|skin(2)|upper_aerodigestive_tract(1)	22						GGCAGCACACTGGGGGGCTTAT	0.594													9	613	---	---	---	---					
BSCL2	26580	broad.mit.edu	37	11	62458782	62458783	+	Frame_Shift_Ins	INS	-	-	C			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr11:62458782_62458783insC	ENST00000433053.1	-	8	1530_1531	c.974_975insG	c.(973-975)gatfs	p.D325fs	BSCL2_ENST00000421906.1_Frame_Shift_Ins_p.D261fs|BSCL2_ENST00000278893.7_Intron|BSCL2_ENST00000403550.1_Frame_Shift_Ins_p.D261fs|BSCL2_ENST00000405837.1_Frame_Shift_Ins_p.D325fs|BSCL2_ENST00000407022.3_Frame_Shift_Ins_p.D261fs|RP11-831H9.16_ENST00000403734.2_3'UTR|BSCL2_ENST00000360796.5_Frame_Shift_Ins_p.D325fs			Q96G97	BSCL2_HUMAN	Berardinelli-Seip congenital lipodystrophy 2 (seipin)	261					cell death	integral to endoplasmic reticulum membrane				endometrium(2)|kidney(2)|large_intestine(2)|lung(4)|prostate(1)|skin(1)	12						GGGGCCAGATGCCCCCCCACAC	0.559													11	177	---	---	---	---					
DPP3	10072	broad.mit.edu	37	11	66272154	66272155	+	Frame_Shift_Ins	INS	-	-	C	rs142447712		TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr11:66272154_66272155insC	ENST00000532677.1	+	17	2408_2409	c.2007_2008insC	c.(2005-2010)gcccccfs	p.AP669fs	DPP3_ENST00000531863.1_Frame_Shift_Ins_p.AP670fs|DPP3_ENST00000360510.2_Frame_Shift_Ins_p.AP650fs|DPP3_ENST00000541961.1_Frame_Shift_Ins_p.AP650fs|DPP3_ENST00000453114.1_Frame_Shift_Ins_p.AP650fs|DPP3_ENST00000530165.1_Frame_Shift_Ins_p.AP620fs	NM_001256670.1|NM_005700.4|NM_130443.3	NP_001243599.1|NP_005691.2|NP_569710.2	Q9NY33	DPP3_HUMAN	dipeptidyl-peptidase 3	650					proteolysis	cytoplasm	aminopeptidase activity|dipeptidyl-peptidase activity|metal ion binding|metallopeptidase activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(8)|ovary(1)|prostate(1)|skin(2)|stomach(1)	23						TCACTGATGCGCCCCCCGAGTG	0.579													7	231	---	---	---	---					
PPFIA1	8500	broad.mit.edu	37	11	70194406	70194407	+	Frame_Shift_Ins	INS	-	-	C			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr11:70194406_70194407insC	ENST00000253925.7	+	16	2258_2259	c.2043_2044insC	c.(2041-2046)atccccfs	p.IP681fs	PPFIA1_ENST00000389547.3_Frame_Shift_Ins_p.IP681fs|AP000487.6_ENST00000528607.1_RNA	NM_003626.3	NP_003617.1	Q13136	LIPA1_HUMAN	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1	681					cell-matrix adhesion	cytoplasm	protein binding|signal transducer activity			breast(3)|cervix(1)|endometrium(5)|kidney(5)|large_intestine(11)|lung(31)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	65			BRCA - Breast invasive adenocarcinoma(2;1.04e-44)|LUSC - Lung squamous cell carcinoma(11;1.46e-14)|STAD - Stomach adenocarcinoma(18;0.0513)			TGAGCTCCATTCCCCCCTACCC	0.554													10	630	---	---	---	---					
SYTL2	54843	broad.mit.edu	37	11	85435355	85435356	+	Frame_Shift_Ins	INS	-	-	G			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr11:85435355_85435356insG	ENST00000359152.5	-	1	3715_3716	c.3716_3717insC	c.(3715-3717)cgafs	p.R1239fs	SYTL2_ENST00000524452.1_Intron|SYTL2_ENST00000389960.4_Intron|SYTL2_ENST00000316356.4_Intron|SYTL2_ENST00000525423.1_Frame_Shift_Ins_p.R715fs|SYTL2_ENST00000354566.3_Frame_Shift_Ins_p.R715fs|SYTL2_ENST00000528231.1_Intron|SYTL2_ENST00000527523.1_Intron	NM_206928.2	NP_996811.1	Q9HCH5	SYTL2_HUMAN	synaptotagmin-like 2	400					intracellular protein transport|vesicle docking involved in exocytosis	exocytic vesicle|extrinsic to plasma membrane|melanosome|membrane fraction	neurexin binding|phosphatidylinositol-4,5-bisphosphate binding|phosphatidylserine binding|Rab GTPase binding			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(22)|ovary(2)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	52		Acute lymphoblastic leukemia(157;4.19e-06)|all_hematologic(158;0.0033)		KIRC - Kidney renal clear cell carcinoma(183;0.202)|Kidney(183;0.237)		CCCTGTCCTCTGGGGGGGTTAC	0.480													12	259	---	---	---	---					
BACE1	23621	broad.mit.edu	37	11	117167622	117167623	+	Frame_Shift_Ins	INS	-	-	G			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr11:117167622_117167623insG	ENST00000313005.6	-	2	776_777	c.316_317insC	c.(316-318)cccfs	p.P106fs	BACE1_ENST00000445823.2_Frame_Shift_Ins_p.P106fs|BACE1_ENST00000428381.2_Frame_Shift_Ins_p.P106fs|BACE1_ENST00000528053.1_Frame_Shift_Ins_p.P106fs|BACE1_ENST00000514464.1_5'UTR|BACE1_ENST00000513780.1_Frame_Shift_Ins_p.P106fs	NM_012104.4|NM_138971.3|NM_138972.3|NM_138973.3	NP_036236.1|NP_620427.1|NP_620428.1|NP_620429.1	P56817	BACE1_HUMAN	beta-site APP-cleaving enzyme 1	106					beta-amyloid metabolic process|membrane protein ectodomain proteolysis	cell surface|cytoplasmic vesicle membrane|endoplasmic reticulum|endosome|integral to plasma membrane|trans-Golgi network	aspartic-type endopeptidase activity|beta-aspartyl-peptidase activity|protein binding			breast(2)|endometrium(4)|kidney(1)|large_intestine(2)|lung(7)|ovary(2)|prostate(1)	19	all_hematologic(175;0.0487)	Breast(348;0.00908)|Medulloblastoma(222;0.0425)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;1.69e-05)|Epithelial(105;0.000563)|all cancers(92;0.0032)		CAGGAAGGGGTGGGGGGCAGCA	0.569													7	305	---	---	---	---					
CCDC153	283152	broad.mit.edu	37	11	119061042	119061043	+	Frame_Shift_Ins	INS	-	-	G			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr11:119061042_119061043insG	ENST00000503566.2	-	6	598_599	c.599_600insC	c.(598-600)cggfs	p.R200fs	CCDC153_ENST00000415318.1_Frame_Shift_Ins_p.R200fs			Q494R4	CC153_HUMAN	coiled-coil domain containing 153	200										lung(3)|stomach(1)	4						TCAAAGATCCAGGGGGGGTGAG	0.569													11	286	---	---	---	---					
OR10G8	219869	broad.mit.edu	37	11	123900396	123900397	+	Frame_Shift_Ins	INS	-	-	C			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr11:123900396_123900397insC	ENST00000431524.1	+	1	100_101	c.67_68insC	c.(67-69)cccfs	p.P23fs		NM_001004464.1	NP_001004464.1	Q8NGN5	O10G8_HUMAN	olfactory receptor, family 10, subfamily G, member 8	23					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.A23T(1)		breast(1)|endometrium(7)|large_intestine(2)|lung(21)|ovary(1)|prostate(5)|skin(1)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	44		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0521)		AGCGCTGGACGCCCCCCTCTTT	0.589													7	1110	---	---	---	---					
PRDM10	56980	broad.mit.edu	37	11	129827737	129827738	+	Frame_Shift_Ins	INS	-	-	G			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr11:129827737_129827738insG	ENST00000358825.5	-	3	368_369	c.137_138insC	c.(136-138)ccafs	p.P46fs	PRDM10_ENST00000528746.1_Frame_Shift_Ins_p.P46fs|PRDM10_ENST00000360871.3_Frame_Shift_Ins_p.P46fs	NM_020228.2	NP_064613.2	Q9NQV6	PRD10_HUMAN	PR domain containing 10	46					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(6)|kidney(3)|large_intestine(14)|lung(15)|pancreas(2)|skin(1)|stomach(3)|urinary_tract(2)	48	all_hematologic(175;0.0537)	Breast(109;0.000496)|Lung NSC(97;0.000693)|all_lung(97;0.00151)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.0174)|Lung(977;0.176)|LUSC - Lung squamous cell carcinoma(976;0.185)		CCACCTGCTGTGGGGGGCGAAC	0.545													13	640	---	---	---	---					
IGSF9B	22997	broad.mit.edu	37	11	133807826	133807827	+	Frame_Shift_Ins	INS	-	-	G			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr11:133807826_133807827insG	ENST00000321016.8	-	4	669_670	c.439_440insC	c.(439-441)gtafs	p.V147fs	IGSF9B_ENST00000533871.2_Frame_Shift_Ins_p.V147fs			Q9UPX0	TUTLB_HUMAN	immunoglobulin superfamily, member 9B	147	Ig-like 2.					integral to membrane|plasma membrane				breast(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(18)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	44	all_hematologic(175;0.127)	all_cancers(12;1.58e-21)|all_epithelial(12;5.17e-16)|all_lung(97;1.6e-05)|Lung NSC(97;3.86e-05)|Breast(109;0.000126)|Medulloblastoma(222;0.0245)|all_neural(223;0.0505)|Esophageal squamous(93;0.0559)		Epithelial(10;7.19e-10)|BRCA - Breast invasive adenocarcinoma(10;9.69e-09)|all cancers(11;1.23e-08)|OV - Ovarian serous cystadenocarcinoma(99;0.00328)|Lung(977;0.221)		CTCGATGTACTGGGGGGGTGTT	0.574													11	160	---	---	---	---					
NCAPD3	23310	broad.mit.edu	37	11	134048585	134048586	+	Frame_Shift_Ins	INS	-	-	G	rs138442478		TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr11:134048585_134048586insG	ENST00000534548.2	-	22	2789_2790	c.2725_2726insC	c.(2725-2727)ggtfs	p.G909fs		NM_015261.2	NP_056076.1	P42695	CNDD3_HUMAN	non-SMC condensin II complex, subunit D3	909					cell division|mitotic chromosome condensation	nuclear centromeric heterochromatin|nuclear condensin complex	methylated histone residue binding	p.Q909fs*12(1)		NS(1)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(10)|kidney(5)|large_intestine(9)|liver(1)|lung(28)|ovary(3)|prostate(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	71	all_hematologic(175;0.127)	all_cancers(12;1.68e-21)|all_epithelial(12;5.86e-16)|all_lung(97;1.19e-05)|Lung NSC(97;2.76e-05)|Breast(109;0.000182)|Medulloblastoma(222;0.0245)|all_neural(223;0.0505)|Esophageal squamous(93;0.0559)		Epithelial(10;8.74e-10)|BRCA - Breast invasive adenocarcinoma(10;1e-08)|all cancers(11;1.46e-08)|OV - Ovarian serous cystadenocarcinoma(99;0.00345)|Lung(977;0.227)		ACCTCTGACCTGGGGGGGTGGC	0.525													7	308	---	---	---	---					
VWF	7450	broad.mit.edu	37	12	6153463	6153464	+	Frame_Shift_Ins	INS	-	-	G	rs137990643	by1000genomes	TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr12:6153463_6153464insG	ENST00000261405.5	-	18	2689_2690	c.2435_2436insC	c.(2434-2436)cggfs	p.R812fs		NM_000552.3	NP_000543.2	P04275	VWF_HUMAN	von Willebrand factor	812	E1.|TIL 3.				blood coagulation, intrinsic pathway|cell-substrate adhesion|platelet activation|platelet degranulation|protein homooligomerization	endoplasmic reticulum|platelet alpha granule lumen|proteinaceous extracellular matrix|Weibel-Palade body	chaperone binding|collagen binding|glycoprotein binding|immunoglobulin binding|integrin binding|protease binding|protein homodimerization activity|protein N-terminus binding			NS(1)|breast(6)|central_nervous_system(5)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(25)|lung(41)|ovary(7)|pancreas(2)|prostate(6)|skin(15)|stomach(1)|upper_aerodigestive_tract(5)	129					Antihemophilic Factor(DB00025)	TCACCATGCCCGGGGGGCAGAG	0.594													8	302	---	---	---	---					
CD4	920	broad.mit.edu	37	12	6924042	6924043	+	Frame_Shift_Ins	INS	-	-	G			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr12:6924042_6924043insG	ENST00000011653.4	+	5	749_750	c.491_492insG	c.(490-492)cggfs	p.R164fs	CD4_ENST00000541982.1_Frame_Shift_Ins_p.R109fs|CD4_ENST00000538827.1_3'UTR	NM_000616.4|NM_001195015.2|NM_001195016.2|NM_001195017.2	NP_000607.1|NP_001181944.1|NP_001181945.1|NP_001181946.1	P01730	CD4_HUMAN	CD4 molecule	164	Ig-like C2-type 1.				cell adhesion|entry into host cell|immune response|induction by virus of host cell-cell fusion|initiation of viral infection|maintenance of protein location in cell|positive regulation of interleukin-2 biosynthetic process|positive regulation of protein kinase activity|protein palmitoleylation|regulation of defense response to virus by virus|T cell costimulation|T cell receptor signaling pathway|T cell selection|transmembrane receptor protein tyrosine kinase signaling pathway	early endosome|endoplasmic reticulum membrane|integral to membrane|T cell receptor complex	coreceptor activity|extracellular matrix structural constituent|glycoprotein binding|MHC class II protein binding|protein homodimerization activity|protein kinase binding|transmembrane receptor activity|zinc ion binding			breast(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(7)|ovary(1)|prostate(1)	23		Myeloproliferative disorder(1001;0.0122)				AAAAACATACAGGGGGGGAAGA	0.564													14	425	---	---	---	---					
M6PR	4074	broad.mit.edu	37	12	9095101	9095102	+	Frame_Shift_Ins	INS	-	-	C			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr12:9095101_9095102insC	ENST00000000412.3	-	6	1089_1090	c.621_622insG	c.(619-624)ggtcctfs	p.P208fs		NM_002355.3	NP_002346.1	P20645	MPRD_HUMAN	mannose-6-phosphate receptor (cation dependent)	208					endosome to lysosome transport|receptor-mediated endocytosis	cell surface|endosome|integral to plasma membrane|lysosomal membrane	mannose binding|mannose transmembrane transporter activity|transmembrane receptor activity			cervix(1)|endometrium(6)|kidney(1)|large_intestine(2)|lung(1)	11		Hepatocellular(102;0.137)		BRCA - Breast invasive adenocarcinoma(232;0.0146)		TGGTATAGGAACCCCCCAACAA	0.450													8	391	---	---	---	---					
PRB1	5542	broad.mit.edu	37	12	11506884	11506885	+	Frame_Shift_Ins	INS	-	-	G			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr12:11506884_11506885insG	ENST00000500254.2	-	3	189_190	c.152_153insC	c.(151-153)cccfs	p.P51fs	PRB1_ENST00000546254.1_Frame_Shift_Ins_p.P51fs|PRB1_ENST00000545626.1_Frame_Shift_Ins_p.P51fs	NM_005039.3|NM_199353.2	NP_005030.2|NP_955385.1	P04280	PRP1_HUMAN	proline-rich protein BstNI subfamily 1	234						extracellular region				NS(1)|central_nervous_system(1)|kidney(4)|large_intestine(1)|lung(9)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	20			OV - Ovarian serous cystadenocarcinoma(49;0.185)			CTGGAGGAGGTGGGGGGCCCTG	0.579													11	1057	---	---	---	---					
PRB2	653247	broad.mit.edu	37	12	11546135	11546137	+	In_Frame_Del	DEL	TGC	TGC	-			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr12:11546135_11546137delTGC	ENST00000389362.4	-	3	910_912	c.875_877delGCA	c.(874-879)aag>a	p.SK292del	PRB1_ENST00000546254.1_Intron	NM_006248.3	NP_006239.3			proline-rich protein BstNI subfamily 2											NS(1)|breast(1)|endometrium(2)|kidney(3)|large_intestine(3)|lung(14)|pancreas(1)|prostate(5)|skin(4)|stomach(2)|urinary_tract(1)	37		all_cancers(2;0.00558)|Acute lymphoblastic leukemia(2;3.94e-11)|all_hematologic(2;3.6e-09)	OV - Ovarian serous cystadenocarcinoma(49;0.185)			CTTCGGGACTTGCTGCCTCCTTG	0.606													7	1267	---	---	---	---					
HEBP1	50865	broad.mit.edu	37	12	13142224	13142225	+	Frame_Shift_Ins	INS	-	-	C			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr12:13142224_13142225insC	ENST00000536942.1	-	2	353_354	c.203_204insG	c.(202-204)gacfs	p.D68fs	HEBP1_ENST00000014930.4_Frame_Shift_Ins_p.D68fs			Q9NRV9	HEBP1_HUMAN	heme binding protein 1	68					circadian rhythm	extracellular region				breast(1)|endometrium(1)|large_intestine(3)|lung(1)|urinary_tract(1)	7		Prostate(47;0.183)		BRCA - Breast invasive adenocarcinoma(232;0.153)		TGTCATTGGTGCCCCCCGCATA	0.554													17	1020	---	---	---	---					
GRIN2B	2904	broad.mit.edu	37	12	14019043	14019044	+	Frame_Shift_Ins	INS	-	-	G	rs77738206		TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr12:14019043_14019044insG	ENST00000279593.3	-	2	308_309	c.99_100insC	c.(97-102)ccgcatfs	p.H34fs		NM_000834.3	NP_000825.2	Q13224	NMDE2_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 2B	34					response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	glycine binding|N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(5)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(12)|liver(1)|lung(70)|ovary(4)|prostate(6)|skin(10)|upper_aerodigestive_tract(5)|urinary_tract(1)	143					Felbamate(DB00949)|Haloperidol(DB00502)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	ATGCCAATGCTGGGGGGGCTCT	0.589													14	203	---	---	---	---					
WBP11	51729	broad.mit.edu	37	12	14940365	14940366	+	Frame_Shift_Ins	INS	-	-	G			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr12:14940365_14940366insG	ENST00000261167.2	-	12	1792_1793	c.1559_1560insC	c.(1558-1560)cggfs	p.R520fs	WBP11_ENST00000537574.1_Frame_Shift_Ins_p.R486fs	NM_016312.2	NP_057396.1	Q9Y2W2	WBP11_HUMAN	WW domain binding protein 11	520	Pro-rich.				mRNA processing|RNA splicing|rRNA processing	cytoplasm	single-stranded DNA binding|WW domain binding	p.G521fs*28(1)		endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(16)|ovary(1)|prostate(1)	30						GGAACAGCCCAGGGGGGGCAGG	0.550													12	246	---	---	---	---					
KLHL42	57542	broad.mit.edu	37	12	27950768	27950769	+	Frame_Shift_Ins	INS	-	-	G	rs145908611	byFrequency	TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr12:27950768_27950769insG	ENST00000381271.2	+	3	1498_1499	c.1187_1188insG	c.(1186-1188)gggfs	p.G396fs		NM_020782.1	NP_065833.1			kelch-like family member 42																		ATCTACATCGTGGGGGGGTGTC	0.594													25	464	---	---	---	---					
SCAF11	9169	broad.mit.edu	37	12	46315840	46315841	+	Frame_Shift_Ins	INS	-	-	T			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr12:46315840_46315841insT	ENST00000465950.1	-	5	4646_4647	c.3437_3438insA	c.(3436-3438)aatfs	p.N1146fs	SCAF11_ENST00000369367.3_Frame_Shift_Ins_p.N1461fs|SCAF11_ENST00000419565.2_Frame_Shift_Ins_p.N1461fs|SCAF11_ENST00000549162.1_Frame_Shift_Ins_p.N1269fs|SCAF11_ENST00000550629.1_Intron			Q99590	SCAFB_HUMAN	SR-related CTD-associated factor 11	1461					spliceosome assembly	nucleus	protein binding|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(8)|large_intestine(17)|lung(25)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	69						TTCAGCCTATGTTTTTTTCAGT	0.376													8	422	---	---	---	---					
AAAS	8086	broad.mit.edu	37	12	53715141	53715142	+	Frame_Shift_Ins	INS	-	-	G	rs138043864		TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr12:53715141_53715142insG	ENST00000209873.4	-	1	273_274	c.108_109insC	c.(106-111)ccacttfs	p.L37fs	AAAS_ENST00000549983.1_Intron|AAAS_ENST00000550286.1_Intron|AAAS_ENST00000394384.3_Frame_Shift_Ins_p.L37fs	NM_015665.5	NP_056480.1	Q9NRG9	AAAS_HUMAN	achalasia, adrenocortical insufficiency, alacrimia	37					carbohydrate metabolic process|glucose transport|nucleocytoplasmic transport|regulation of glucose transport|regulation of nucleocytoplasmic transport|transmembrane transport|viral reproduction	nuclear pore				breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(5)|ovary(1)|prostate(1)|skin(2)	20						CCCCGGAAGTCGGGGGGCGGGC	0.653													7	216	---	---	---	---					
PCBP2	5094	broad.mit.edu	37	12	53856277	53856278	+	Frame_Shift_Ins	INS	-	-	C			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr12:53856277_53856278insC	ENST00000603815.1	+	8	867_868	c.517_518insC	c.(517-519)cccfs	p.P173fs	PCBP2_ENST00000447282.1_Frame_Shift_Ins_p.P173fs|PCBP2_ENST00000359462.5_Frame_Shift_Ins_p.P173fs|PCBP2_ENST00000549863.1_Frame_Shift_Ins_p.P173fs|PCBP2_ENST00000455667.3_Splice_Site_p.P169_splice|PCBP2_ENST00000548933.1_Frame_Shift_Ins_p.P173fs|PCBP2_ENST00000359282.5_Splice_Site_p.P169_splice|PCBP2_ENST00000439930.3_Frame_Shift_Ins_p.P173fs|PCBP2_ENST00000552819.1_Frame_Shift_Ins_p.P173fs|PCBP2_ENST00000552296.2_Splice_Site_p.P169_splice|PCBP2_ENST00000437231.1_Splice_Site_p.P169_splice|PCBP2_ENST00000546463.1_Splice_Site_p.P169_splice|RP11-793H13.8_ENST00000547717.1_RNA|PCBP2_ENST00000541275.1_Splice_Site_p.P169_splice	NM_001128911.1|NM_001128912.1|NM_005016.5|NM_031989.4	NP_001122383.1|NP_001122384.1|NP_005007.2|NP_114366.1	Q15366	PCBP2_HUMAN	poly(rC) binding protein 2	173					innate immune response|negative regulation of defense response to virus|negative regulation of type I interferon production|nuclear mRNA splicing, via spliceosome|proteasomal ubiquitin-dependent protein catabolic process|response to virus	cytosol|nucleoplasm|ribonucleoprotein complex	DNA binding|RNA binding|ubiquitin protein ligase binding			central_nervous_system(4)|endometrium(2)|kidney(1)|large_intestine(2)|lung(4)|skin(1)|upper_aerodigestive_tract(1)	15						TCTCTCCCAGTCCCCCCCGAAG	0.500													19	251	---	---	---	---					
DGKA	1606	broad.mit.edu	37	12	56347513	56347514	+	Frame_Shift_Ins	INS	-	-	C			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr12:56347513_56347514insC	ENST00000331886.5	+	24	2623_2624	c.2169_2170insC	c.(2167-2172)ccccccfs	p.PP723fs	DGKA_ENST00000549079.2_3'UTR|DGKA_ENST00000551156.1_Frame_Shift_Ins_p.PP723fs|DGKA_ENST00000394147.1_Frame_Shift_Ins_p.PP723fs	NM_001345.4	NP_001336.2	P23743	DGKA_HUMAN	diacylglycerol kinase, alpha 80kDa	723					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	plasma membrane	ATP binding|calcium ion binding|diacylglycerol kinase activity			breast(1)|endometrium(3)|large_intestine(1)|lung(11)|ovary(4)|pancreas(1)|skin(3)|urinary_tract(1)	25					Vitamin E(DB00163)	TCATGGGCCCACCCCCCCGCTC	0.579													12	348	---	---	---	---					
IKZF4	64375	broad.mit.edu	37	12	56429092	56429093	+	Frame_Shift_Ins	INS	-	-	G			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr12:56429092_56429093insG	ENST00000262032.5	+	12	2102_2103	c.1735_1736insG	c.(1735-1737)gggfs	p.G579fs	IKZF4_ENST00000431367.2_Frame_Shift_Ins_p.G477fs|IKZF4_ENST00000547167.1_Frame_Shift_Ins_p.G579fs|IKZF4_ENST00000547791.1_Frame_Shift_Ins_p.G534fs|RP11-603J24.4_ENST00000551846.1_RNA			Q9H2S9	IKZF4_HUMAN	IKAROS family zinc finger 4 (Eos)	579					negative regulation of transcription, DNA-dependent	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|endometrium(2)|lung(3)|ovary(1)|prostate(1)	8			UCEC - Uterine corpus endometrioid carcinoma (6;0.025)|OV - Ovarian serous cystadenocarcinoma(18;0.123)			CCACATTGTCCGGGGGGAGCAT	0.554													14	795	---	---	---	---					
SMARCC2	6601	broad.mit.edu	37	12	56559112	56559113	+	Frame_Shift_Ins	INS	-	-	G			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr12:56559112_56559113insG	ENST00000394023.3	-	27	3326_3327	c.3221_3222insC	c.(3220-3222)cggfs	p.R1074fs	SMARCC2_ENST00000550164.1_Frame_Shift_Ins_p.R1074fs|SMARCC2_ENST00000347471.4_Frame_Shift_Ins_p.R1074fs|SMARCC2_ENST00000267064.4_Frame_Shift_Ins_p.R1043fs|RP11-977G19.5_ENST00000553176.1_RNA	NM_001130420.1	NP_001123892.1	Q8TAQ2	SMRC2_HUMAN	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2	1043	Pro-rich.				chromatin remodeling|negative regulation of transcription, DNA-dependent|nervous system development|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nBAF complex|npBAF complex|nucleoplasm|SWI/SNF complex	DNA binding|protein binding|transcription coactivator activity			breast(1)|central_nervous_system(3)|endometrium(6)|kidney(3)|large_intestine(3)|lung(20)|ovary(1)|skin(2)|soft_tissue(1)|upper_aerodigestive_tract(1)	41			OV - Ovarian serous cystadenocarcinoma(18;0.123)			CATGGGGTCCAGGGGGGGGAAC	0.574													19	283	---	---	---	---					
NACA	4666	broad.mit.edu	37	12	57114417	57114418	+	Frame_Shift_Ins	INS	-	-	G			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr12:57114417_57114418insG	ENST00000454682.1	-	3	1177_1178	c.896_897insC	c.(895-897)cgafs	p.R299fs	NACA_ENST00000546392.1_Intron|NACA_ENST00000356769.3_Intron|NACA_ENST00000552540.1_Intron|NACA_ENST00000393891.4_Intron|NACA_ENST00000548563.1_Intron|NACA_ENST00000550952.1_Frame_Shift_Ins_p.R299fs|NACA_ENST00000551793.1_Intron	NM_001113203.2	NP_001106674.2	Q13765	NACA_HUMAN	nascent polypeptide-associated complex alpha subunit	0					interspecies interaction between organisms|protein transport|transcription, DNA-dependent|translation	nascent polypeptide-associated complex|nucleus	DNA binding			breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(1)|ovary(2)|upper_aerodigestive_tract(1)	10						TGGGAAAATCTGGGGGGGTGTT	0.490			T	BCL6	NHL								8	89	---	---	---	---					
LRP1	4035	broad.mit.edu	37	12	57572241	57572242	+	Frame_Shift_Ins	INS	-	-	G	rs139915490		TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr12:57572241_57572242insG	ENST00000243077.3	+	27	4927_4928	c.4461_4462insG	c.(4459-4464)taggggfs	p.*G1487fs		NM_002332.2	NP_002323.2	Q07954	LRP1_HUMAN	low density lipoprotein receptor-related protein 1	1487					aorta morphogenesis|apoptotic cell clearance|negative regulation of platelet-derived growth factor receptor-beta signaling pathway|negative regulation of smooth muscle cell migration|negative regulation of Wnt receptor signaling pathway|positive regulation of cholesterol efflux|regulation of actin cytoskeleton organization|regulation of phospholipase A2 activity	coated pit|integral to plasma membrane|nucleus	apolipoprotein E binding|calcium ion binding|lipoprotein transporter activity|protein complex binding|receptor activity			NS(1)|breast(9)|central_nervous_system(3)|cervix(3)|endometrium(33)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(26)|lung(58)|ovary(10)|pancreas(2)|prostate(11)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(5)	184				BRCA - Breast invasive adenocarcinoma(357;0.0103)	Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Becaplermin(DB00102)|Coagulation Factor IX(DB00100)|Tenecteplase(DB00031)	TGACGCTGTACGGGGGGGAGGT	0.589													18	260	---	---	---	---					
CDK4	1019	broad.mit.edu	37	12	58143030	58143031	+	Frame_Shift_Ins	INS	-	-	G			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr12:58143030_58143031insG	ENST00000257904.6	-	7	1118_1119	c.753_754insC	c.(751-756)ccgaggfs	p.R252fs	CDK4_ENST00000540325.1_Frame_Shift_Ins_p.R132fs|CDK4_ENST00000312990.6_3'UTR|TSPAN31_ENST00000547992.1_3'UTR|CDK4_ENST00000551888.1_5'UTR|CDK4_ENST00000549606.1_5'UTR	NM_000075.3	NP_000066.1	P11802	CDK4_HUMAN	cyclin-dependent kinase 4	252	Protein kinase.				cell division|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|positive regulation of fibroblast proliferation|regulation of gene expression|response to drug|S phase of mitotic cell cycle	cyclin-dependent protein kinase holoenzyme complex|cytosol|membrane	ATP binding|cyclin-dependent protein kinase activity|protein binding			breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(4)|lung(6)|prostate(1)|skin(2)	21	all_cancers(7;4.96e-69)|Lung NSC(6;5.5e-25)|all_lung(6;3.87e-23)|all_epithelial(6;1.66e-15)|Glioma(12;6.95e-05)|all_neural(12;0.00016)|Melanoma(17;0.122)		GBM - Glioblastoma multiforme(5;4.21e-120)|all cancers(5;3.75e-83)|BRCA - Breast invasive adenocarcinoma(9;0.0294)			CGGGGCCCTCTGGGGGGAAAGG	0.624			Mis			melanoma			Hereditary Melanoma				7	242	---	---	---	---					
MDM2	4193	broad.mit.edu	37	12	69233089	69233090	+	Frame_Shift_Ins	INS	-	-	C			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr12:69233089_69233090insC	ENST00000462284.1	+	11	1256_1257	c.954_955insC	c.(952-957)aaccccfs	p.NP318fs	MDM2_ENST00000478070.1_3'UTR|MDM2_ENST00000540827.1_Frame_Shift_Ins_p.NP117fs|MDM2_ENST00000517852.1_Intron|MDM2_ENST00000544561.1_Intron|MDM2_ENST00000545204.1_Intron|MDM2_ENST00000258148.7_Frame_Shift_Ins_p.NP263fs|MDM2_ENST00000393410.1_Frame_Shift_Ins_p.NP64fs|MDM2_ENST00000428863.2_Frame_Shift_Ins_p.NP91fs|MDM2_ENST00000360430.2_Frame_Shift_Ins_p.NP117fs|MDM2_ENST00000299252.4_Frame_Shift_Ins_p.NP142fs|MDM2_ENST00000350057.5_Frame_Shift_Ins_p.NP287fs|MDM2_ENST00000356290.4_Frame_Shift_Ins_p.NP142fs|MDM2_ENST00000393412.3_Frame_Shift_Ins_p.NP39fs|MDM2_ENST00000348801.2_Frame_Shift_Ins_p.NP86fs|MDM2_ENST00000258149.5_Frame_Shift_Ins_p.NP257fs|MDM2_ENST00000393413.3_Frame_Shift_Ins_p.NP39fs	NM_002392.4	NP_002383.2	Q00987	MDM2_HUMAN	MDM2 oncogene, E3 ubiquitin protein ligase	312	Necessary for interaction with USP2.|Region II.				cellular response to hypoxia|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|establishment of protein localization|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell cycle arrest|negative regulation of DNA damage response, signal transduction by p53 class mediator|negative regulation of transcription from RNA polymerase II promoter|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of cell proliferation|positive regulation of mitotic cell cycle|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|protein complex assembly|protein destabilization|protein localization to nucleus|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to antibiotic|synaptic transmission	cytosol|endocytic vesicle membrane|insoluble fraction|nucleolus|nucleoplasm|plasma membrane|protein complex	enzyme binding|identical protein binding|p53 binding|ubiquitin-protein ligase activity|zinc ion binding			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(4)|liver(2)|lung(8)|prostate(1)|urinary_tract(1)	19	all_cancers(1;8.46e-121)|all_epithelial(5;3.21e-36)|Lung NSC(4;2.16e-33)|all_lung(4;3.03e-31)|Glioma(1;1.9e-09)|Breast(13;1.59e-06)|all_neural(1;1.03e-05)|Melanoma(1;0.0171)|Renal(347;0.0684)		all cancers(2;8.67e-65)|GBM - Glioblastoma multiforme(2;8.89e-62)|BRCA - Breast invasive adenocarcinoma(5;2.43e-08)|Lung(24;1.5e-05)|LUAD - Lung adenocarcinoma(15;8.5e-05)|STAD - Stomach adenocarcinoma(21;0.00372)|Kidney(9;0.143)			ATGAAATGAATCCCCCCCTTCC	0.426			A		"""sarcoma, glioma, colorectal, other"""								16	445	---	---	---	---					
NAV3	89795	broad.mit.edu	37	12	78400511	78400512	+	Frame_Shift_Ins	INS	-	-	C			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr12:78400511_78400512insC	ENST00000397909.2	+	8	1366_1367	c.1193_1194insC	c.(1192-1194)cccfs	p.P398fs	NAV3_ENST00000266692.7_Frame_Shift_Ins_p.P398fs|NAV3_ENST00000228327.6_Frame_Shift_Ins_p.P398fs|NAV3_ENST00000536525.2_Frame_Shift_Ins_p.P398fs			Q8IVL0	NAV3_HUMAN	neuron navigator 3	398						nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			NS(2)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(13)|kidney(16)|large_intestine(39)|liver(2)|lung(126)|ovary(5)|pancreas(3)|prostate(6)|skin(5)|stomach(2)|upper_aerodigestive_tract(8)|urinary_tract(1)	236						ACTGCTTTACGCCCCCCGCAGC	0.495										HNSCC(70;0.22)			15	254	---	---	---	---					
UHRF1BP1L	23074	broad.mit.edu	37	12	100451839	100451840	+	Frame_Shift_Ins	INS	-	-	G			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr12:100451839_100451840insG	ENST00000279907.7	-	14	3427_3428	c.3215_3216insC	c.(3214-3216)cgtfs	p.R1072fs	UHRF1BP1L_ENST00000545232.2_Frame_Shift_Ins_p.R722fs	NM_015054.1	NP_055869.1	A0JNW5	UH1BL_HUMAN	UHRF1 binding protein 1-like	1072										breast(3)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(5)|large_intestine(9)|lung(21)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)	50						GTGTTCTAACTGGGGGGGTCTC	0.371													14	281	---	---	---	---					
HECTD4	283450	broad.mit.edu	37	12	112600859	112600860	+	Frame_Shift_Ins	INS	-	-	G			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr12:112600859_112600860insG	ENST00000550722.1	-	75	13063_13064	c.12668_12669insC	c.(12667-12669)cgafs	p.R4223fs	HECTD4_ENST00000430131.2_Frame_Shift_Ins_p.R3947fs|HECTD4_ENST00000377560.5_Frame_Shift_Ins_p.R4197fs	NM_001109662.3	NP_001103132.3			HECT domain containing E3 ubiquitin protein ligase 4																		CTGTGCCATCTGGGGGGGCGAT	0.629													14	319	---	---	---	---					
MSI1	4440	broad.mit.edu	37	12	120800902	120800903	+	Frame_Shift_Ins	INS	-	-	C			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr12:120800902_120800903insC	ENST00000257552.2	-	6	433_434	c.345_346insG	c.(343-348)ggtgtcfs	p.V116fs		NM_002442.3	NP_002433.1	O43347	MSI1H_HUMAN	musashi RNA-binding protein 1	116	RRM 2.				nervous system development	cytoplasm|nucleus	nucleotide binding			breast(4)|central_nervous_system(2)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(5)|skin(2)	19	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					TTCACCGACAGCCCCCCCACAA	0.564													22	362	---	---	---	---					
SLITRK5	26050	broad.mit.edu	37	13	88330396	88330397	+	Frame_Shift_Ins	INS	-	-	C			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr13:88330396_88330397insC	ENST00000325089.6	+	2	2972_2973	c.2753_2754insC	c.(2752-2754)accfs	p.T918fs	SLITRK5_ENST00000400028.3_Frame_Shift_Ins_p.T677fs	NM_015567.1	NP_056382.1	O94991	SLIK5_HUMAN	SLIT and NTRK-like family, member 5	918						integral to membrane		p.S918I(1)		breast(1)|central_nervous_system(2)|endometrium(6)|kidney(6)|large_intestine(14)|lung(40)|ovary(2)|pancreas(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(4)	81	all_neural(89;0.101)|Medulloblastoma(90;0.163)					GTGCTCTACAGCCCCCCGAGTG	0.545													7	134	---	---	---	---					
OR4N5	390437	broad.mit.edu	37	14	20612063	20612064	+	Frame_Shift_Ins	INS	-	-	C			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr14:20612063_20612064insC	ENST00000333629.1	+	1	169_170	c.169_170insC	c.(169-171)cccfs	p.P57fs		NM_001004724.1	NP_001004724.1	Q8IXE1	OR4N5_HUMAN	olfactory receptor, family 4, subfamily N, member 5	57					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|lung(23)|ovary(1)|skin(2)|urinary_tract(1)	29	all_cancers(95;0.00108)		Epithelial(56;7.58e-07)|all cancers(55;3.84e-06)	GBM - Glioblastoma multiforme(265;0.0143)		TGGGCTCACAGCCCCCCTCTAT	0.460													10	1261	---	---	---	---					
ARHGEF40	55701	broad.mit.edu	37	14	21546603	21546604	+	Frame_Shift_Ins	INS	-	-	G			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr14:21546603_21546604insG	ENST00000298694.4	+	10	2329_2330	c.2202_2203insG	c.(2200-2205)gaggggfs	p.EG734fs	ARHGEF40_ENST00000298693.3_Frame_Shift_Ins_p.EG734fs			Q8TER5	ARH40_HUMAN	Rho guanine nucleotide exchange factor (GEF) 40	734					regulation of Rho protein signal transduction	cytoplasm	Rho guanyl-nucleotide exchange factor activity			large_intestine(4)|ovary(3)|upper_aerodigestive_tract(2)	9						TGCAGAGGGATGGGGGGGCCAT	0.629													11	242	---	---	---	---					
KCNH5	27133	broad.mit.edu	37	14	63174302	63174303	+	Frame_Shift_Ins	INS	-	-	G	rs35940222		TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr14:63174302_63174303insG	ENST00000322893.7	-	11	3158_3159	c.2890_2891insC	c.(2890-2892)gatfs	p.D964fs	KCNH5_ENST00000420622.2_3'UTR	NM_139318.3	NP_647479.2	Q8NCM2	KCNH5_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 5	964					regulation of transcription, DNA-dependent	integral to membrane	calmodulin binding|two-component sensor activity|voltage-gated potassium channel activity			NS(1)|biliary_tract(1)|breast(3)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(22)|lung(33)|ovary(5)|prostate(2)|skin(17)|upper_aerodigestive_tract(4)|urinary_tract(2)	99				OV - Ovarian serous cystadenocarcinoma(108;0.00958)|BRCA - Breast invasive adenocarcinoma(234;0.168)		ACATGGTATCTGGGGGGGTACT	0.391													17	368	---	---	---	---					
SIPA1L1	26037	broad.mit.edu	37	14	72165808	72165809	+	Frame_Shift_Ins	INS	-	-	G			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr14:72165808_72165809insG	ENST00000555818.1	+	11	3833_3834	c.3485_3486insG	c.(3484-3486)gggfs	p.G1162fs	SIPA1L1_ENST00000537413.1_Frame_Shift_Ins_p.G637fs|SIPA1L1_ENST00000358550.2_Frame_Shift_Ins_p.G1162fs|SIPA1L1_ENST00000381232.3_Frame_Shift_Ins_p.G1162fs	NM_015556.1	NP_056371.1	O43166	SI1L1_HUMAN	signal-induced proliferation-associated 1 like 1	1162					actin cytoskeleton reorganization|activation of Rap GTPase activity|regulation of dendritic spine morphogenesis	cell junction|cytoplasm|dendritic spine|postsynaptic density|postsynaptic membrane|synaptosome	GTPase activator activity			NS(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(11)|kidney(1)|large_intestine(22)|liver(2)|lung(25)|ovary(3)|prostate(3)|skin(3)|stomach(1)	78				all cancers(60;0.00169)|BRCA - Breast invasive adenocarcinoma(234;0.00912)|OV - Ovarian serous cystadenocarcinoma(108;0.0109)		ACTGGTTCTGTGGGGGGCACTT	0.495													7	393	---	---	---	---					
SERPINA1	5265	broad.mit.edu	37	14	94844884	94844885	+	Frame_Shift_Ins	INS	-	-	G	rs143329723	by1000genomes	TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr14:94844884_94844885insG	ENST00000448921.1	-	7	1730_1731	c.1158_1159insC	c.(1156-1161)ccaggtfs	p.G387fs	SERPINA1_ENST00000393087.4_Frame_Shift_Ins_p.G387fs|SERPINA1_ENST00000404814.4_Frame_Shift_Ins_p.G387fs|SERPINA1_ENST00000355814.4_Frame_Shift_Ins_p.G387fs|SERPINA1_ENST00000440909.1_Frame_Shift_Ins_p.G387fs|SERPINA1_ENST00000449399.3_Frame_Shift_Ins_p.G387fs|SERPINA1_ENST00000393088.4_Frame_Shift_Ins_p.G387fs|SERPINA1_ENST00000437397.1_Frame_Shift_Ins_p.G387fs	NM_001002236.2|NM_001127701.1|NM_001127703.1|NM_001127704.1|NM_001127705.1	NP_001002236.1|NP_001121173.1|NP_001121175.1|NP_001121176.1|NP_001121177.1	P01009	A1AT_HUMAN	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1	387	RCL.		E -> K (in Christchurch).		acute-phase response|platelet activation|platelet degranulation|regulation of proteolysis	extracellular space|platelet alpha granule lumen|proteinaceous extracellular matrix	protease binding|serine-type endopeptidase inhibitor activity			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(5)|skin(6)|stomach(1)	24		all_cancers(154;0.0649)|all_epithelial(191;0.223)		Epithelial(152;0.135)|COAD - Colon adenocarcinoma(157;0.207)|all cancers(159;0.221)	Alpha-1-proteinase inhibitor(DB00058)	AACTTGACCTCGGGGGGGATAG	0.490													8	169	---	---	---	---					
IGHG3	3502	broad.mit.edu	37	14	106236280	106236281	+	RNA	INS	-	-	G			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr14:106236280_106236281insG	ENST00000390551.2	-	0	522_523																											CCTTGGGTTTTGGGGGGAAGAG	0.594													10	275	---	---	---	---					
OR4M2	390538	broad.mit.edu	37	15	22369023	22369024	+	Frame_Shift_Ins	INS	-	-	G			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr15:22369023_22369024insG	ENST00000332663.2	+	1	546_547	c.448_449insG	c.(448-450)gggfs	p.G150fs	RP11-69H14.6_ENST00000558896.1_RNA	NM_001004719.2	NP_001004719.2	Q8NGB6	OR4M2_HUMAN	olfactory receptor, family 4, subfamily M, member 2	150					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.R150M(2)|p.R150W(1)		NS(2)|endometrium(2)|kidney(4)|large_intestine(6)|lung(38)|ovary(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(3)	63		all_cancers(20;1.94e-20)|all_epithelial(15;3.94e-18)|Lung NSC(15;8.53e-15)|all_lung(15;2.87e-14)|Breast(32;0.00519)|Colorectal(260;0.101)	GBM - Glioblastoma multiforme(6;0.124)	all cancers(64;1.64e-11)|Epithelial(43;5.81e-10)|BRCA - Breast invasive adenocarcinoma(123;0.000255)|Kidney(6;0.00736)|KIRC - Kidney renal clear cell carcinoma(6;0.0135)|GBM - Glioblastoma multiforme(186;0.0963)		TCTCTCCTGGAGGGGGGGCTTC	0.500													23	878	---	---	---	---					
SNHG14	104472715	broad.mit.edu	37	15	25456924	25456925	+	RNA	INS	-	-	G			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr15:25456924_25456925insG	ENST00000424208.1	+	0	2516				SNHG14_ENST00000450809.1_RNA|SNHG14_ENST00000424333.1_RNA	NR_003305.1																						ATGTGTGGGCAGGGGGGGTGCC	0.554													7	113	---	---	---	---					
HERC1	8925	broad.mit.edu	37	15	63918305	63918306	+	Frame_Shift_Ins	INS	-	-	G			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr15:63918305_63918306insG	ENST00000443617.2	-	71	13240_13241	c.13153_13154insC	c.(13153-13155)gtafs	p.V4385fs		NM_003922.3	NP_003913.3	Q15751	HERC1_HUMAN	HECT and RLD domain containing E3 ubiquitin protein ligase family member 1	4385					protein modification process|transport	cytosol|Golgi apparatus|membrane	acid-amino acid ligase activity|ARF guanyl-nucleotide exchange factor activity			NS(3)|breast(9)|central_nervous_system(4)|endometrium(23)|haematopoietic_and_lymphoid_tissue(1)|kidney(12)|large_intestine(22)|liver(1)|lung(36)|ovary(7)|prostate(4)|skin(3)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	132						CGCCCCATACTGGGGGGGCACT	0.559													8	122	---	---	---	---					
ZNF609	23060	broad.mit.edu	37	15	64973566	64973567	+	Frame_Shift_Ins	INS	-	-	C			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr15:64973566_64973567insC	ENST00000326648.3	+	8	4349_4350	c.4221_4222insC	c.(4219-4224)ccccccfs	p.PP1407fs		NM_015042.1	NP_055857.1	O15014	ZN609_HUMAN	zinc finger protein 609	1407						nucleus	zinc ion binding			breast(3)|central_nervous_system(2)|endometrium(5)|kidney(1)|large_intestine(9)|lung(11)|ovary(1)|pancreas(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	39						CACTCTACCCACCCCCCAGGAG	0.470											OREG0023182	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	8	731	---	---	---	---					
MYO9A	4649	broad.mit.edu	37	15	72270549	72270550	+	Frame_Shift_Ins	INS	-	-	T			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr15:72270549_72270550insT	ENST00000356056.5	-	12	2278_2279	c.1806_1807insA	c.(1804-1809)aacaacfs	p.NN602fs	MYO9A_ENST00000564571.1_Frame_Shift_Ins_p.NN602fs|MYO9A_ENST00000444904.1_Frame_Shift_Ins_p.NN583fs|RP11-390D11.1_ENST00000568391.1_RNA|MYO9A_ENST00000566885.1_Frame_Shift_Ins_p.NN197fs|MYO9A_ENST00000563542.1_5'UTR|MYO9A_ENST00000424560.1_Frame_Shift_Ins_p.NN602fs	NM_006901.3	NP_008832.2	B2RTY4	MYO9A_HUMAN	myosin IXA	602	Myosin head-like 1.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction|visual perception	cytosol|integral to membrane|unconventional myosin complex	actin binding|ATP binding|GTPase activator activity|metal ion binding|motor activity			NS(4)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(29)|lung(27)|ovary(1)|pancreas(1)|prostate(5)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	88						AGTCCTGTTGGTTTTTTGCTAA	0.332													8	449	---	---	---	---					
CHSY1	22856	broad.mit.edu	37	15	101775436	101775437	+	Frame_Shift_Ins	INS	-	-	C	rs74545602	byFrequency	TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr15:101775436_101775437insC	ENST00000254190.3	-	2	1141_1142	c.666_667insG	c.(664-669)ggctggfs	p.W223fs		NM_014918.4	NP_055733.2	Q86X52	CHSS1_HUMAN	chondroitin sulfate synthase 1	223					chondroitin sulfate biosynthetic process	Golgi cisterna membrane|integral to membrane	glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity|metal ion binding|N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity			central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(10)|lung(5)|skin(1)	24	Lung NSC(78;0.00217)|all_lung(78;0.00271)|Melanoma(26;0.00505)		OV - Ovarian serous cystadenocarcinoma(32;0.000932)|LUSC - Lung squamous cell carcinoma(107;0.187)|Lung(145;0.23)			ATCACGCCAGGCCCCCCCATGC	0.614													7	157	---	---	---	---					
ABCC1	4363	broad.mit.edu	37	16	16142119	16142120	+	Frame_Shift_Ins	INS	-	-	C			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr16:16142119_16142120insC	ENST00000399408.2	+	10	1514_1515	c.1339_1340insC	c.(1339-1341)cccfs	p.P447fs	ABCC1_ENST00000399410.3_Frame_Shift_Ins_p.P447fs|ABCC1_ENST00000345148.5_Frame_Shift_Ins_p.P447fs|ABCC1_ENST00000346370.5_Frame_Shift_Ins_p.P447fs|ABCC1_ENST00000351154.5_Frame_Shift_Ins_p.P447fs|ABCC1_ENST00000349029.5_Frame_Shift_Ins_p.P447fs			P33527	MRP1_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 1	447	ABC transmembrane type-1 1.				hormone biosynthetic process|leukotriene biosynthetic process|prostanoid metabolic process|response to drug	Golgi apparatus|integral to plasma membrane|membrane fraction|nucleus	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(3)|endometrium(9)|kidney(3)|large_intestine(12)|lung(20)|ovary(5)|prostate(1)|skin(3)	56					Daunorubicin(DB00694)|Glibenclamide(DB01016)|Probenecid(DB01032)|Saquinavir(DB01232)|Sulfinpyrazone(DB01138)	GATCTGGTCAGCCCCCCTGCAA	0.545													9	360	---	---	---	---					
ACSM5	54988	broad.mit.edu	37	16	20429493	20429494	+	Frame_Shift_Ins	INS	-	-	G			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr16:20429493_20429494insG	ENST00000331849.4	+	3	464_465	c.317_318insG	c.(316-318)cggfs	p.R106fs	ACSM5_ENST00000575584.1_Frame_Shift_Ins_p.R106fs	NM_017888.2	NP_060358.2	Q6NUN0	ACSM5_HUMAN	acyl-CoA synthetase medium-chain family member 5	106					fatty acid metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|GTP binding|metal ion binding	p.L106L(1)		breast(1)|endometrium(6)|kidney(2)|large_intestine(6)|lung(28)|ovary(3)|prostate(1)|skin(3)|urinary_tract(1)	51						GCCAATGTGCTGGGGGGTGCAT	0.619													7	229	---	---	---	---					
RRN3P1	730092	broad.mit.edu	37	16	21814059	21814060	+	RNA	INS	-	-	G			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr16:21814059_21814060insG	ENST00000546471.1	-	0	1607																											CCTATAACAAAGGGGGGGGAAA	0.381													7	122	---	---	---	---					
POLR3E	55718	broad.mit.edu	37	16	22339833	22339834	+	Frame_Shift_Ins	INS	-	-	C			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr16:22339833_22339834insC	ENST00000299853.5	+	19	2036_2037	c.1869_1870insC	c.(1867-1872)ttccccfs	p.FP623fs	POLR3E_ENST00000359210.4_Frame_Shift_Ins_p.FP623fs|POLR3E_ENST00000418581.2_Frame_Shift_Ins_p.FP587fs|POLR3E_ENST00000564209.1_Frame_Shift_Ins_p.FP623fs	NM_001258033.1|NM_001258035.1|NM_018119.3	NP_001244962.1|NP_001244964.1|NP_060589.1	Q9NVU0	RPC5_HUMAN	polymerase (RNA) III (DNA directed) polypeptide E (80kD)	623					innate immune response|response to virus|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase III promoter	nucleoplasm	DNA-directed RNA polymerase activity			central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(7)|lung(10)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	27				GBM - Glioblastoma multiforme(48;0.012)		TTGGTCAGTTTCCCCCCCAGAC	0.574													7	193	---	---	---	---					
TNRC6A	27327	broad.mit.edu	37	16	24802365	24802366	+	Frame_Shift_Ins	INS	-	-	G	rs139212478	byFrequency	TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr16:24802365_24802366insG	ENST00000395799.3	+	6	2531_2532	c.2402_2403insG	c.(2401-2403)cggfs	p.R801fs	TNRC6A_ENST00000315183.7_Frame_Shift_Ins_p.R801fs	NM_014494.2	NP_055309.2	Q8NDV7	TNR6A_HUMAN	trinucleotide repeat containing 6A	801	Sufficient for interaction with EIF2C1 and EIF2C4.				negative regulation of translation involved in gene silencing by miRNA	cytoplasmic mRNA processing body|micro-ribonucleoprotein complex	nucleotide binding|RNA binding			breast(1)|cervix(1)|endometrium(13)|kidney(5)|large_intestine(13)|liver(1)|lung(20)|ovary(3)|skin(2)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	64				GBM - Glioblastoma multiforme(48;0.0394)		TCAAACTGCCAGGGGGGGTGGG	0.510													8	85	---	---	---	---					
ZNF646	9726	broad.mit.edu	37	16	31089750	31089751	+	Frame_Shift_Ins	INS	-	-	T			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr16:31089750_31089751insT	ENST00000394979.2	+	1	2528_2529	c.2105_2106insT	c.(2104-2106)agafs	p.R702fs	ZNF646_ENST00000300850.5_Frame_Shift_Ins_p.R702fs			O15015	ZN646_HUMAN	zinc finger protein 646	702					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			NS(1)|breast(4)|cervix(2)|endometrium(8)|kidney(4)|large_intestine(1)|lung(21)|ovary(1)|prostate(4)|skin(3)	49						CTAGAAGACAATGAAGGCCTGG	0.619													8	36	---	---	---	---					
ITGAD	3681	broad.mit.edu	37	16	31422475	31422476	+	Frame_Shift_Ins	INS	-	-	C			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr16:31422475_31422476insC	ENST00000389202.2	+	13	1484_1485	c.1435_1436insC	c.(1435-1437)cccfs	p.P479fs		NM_005353.2	NP_005344.2	Q13349	ITAD_HUMAN	integrin, alpha D	479					cell-cell adhesion|cell-matrix adhesion|immune response|integrin-mediated signaling pathway	integrin complex	receptor activity			breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|liver(2)|lung(43)|ovary(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	71						CCTCATTGGGGCCCCCCATTAC	0.649													9	694	---	---	---	---					
NKD1	85407	broad.mit.edu	37	16	50667134	50667135	+	Frame_Shift_Ins	INS	-	-	C			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr16:50667134_50667135insC	ENST00000268459.3	+	10	1079_1080	c.855_856insC	c.(853-858)ctccccfs	p.LP285fs		NM_033119.4	NP_149110.1	Q969G9	NKD1_HUMAN	naked cuticle homolog 1 (Drosophila)	285					Wnt receptor signaling pathway	cytoplasm|plasma membrane	calcium ion binding|protein binding			NS(1)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(5)|lung(9)|prostate(1)|urinary_tract(2)	23		all_cancers(37;0.229)		GBM - Glioblastoma multiforme(240;0.243)		AGTCAGAACTGCCCCCCCGCAC	0.599													9	125	---	---	---	---					
COQ9	57017	broad.mit.edu	37	16	57485112	57485113	+	Frame_Shift_Ins	INS	-	-	C			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr16:57485112_57485113insC	ENST00000262507.6	+	2	303_304	c.234_235insC	c.(232-237)tcccccfs	p.SP78fs	COQ9_ENST00000567933.1_Frame_Shift_Ins_p.SP78fs|COQ9_ENST00000567384.1_3'UTR|COQ9_ENST00000567072.1_Frame_Shift_Ins_p.SP78fs	NM_020312.3	NP_064708.1	O75208	COQ9_HUMAN	coenzyme Q9	78					ubiquinone biosynthetic process	mitochondrion				breast(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(3)|lung(6)|prostate(1)	16						CTTCTCATTCACCCCCCAGGTA	0.495													7	228	---	---	---	---					
NPIPB15	440348	broad.mit.edu	37	16	74423894	74423895	+	Splice_Site	INS	-	-	C			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr16:74423894_74423895insC	ENST00000429990.1	+	6	704_705	c.606_splice	c.e6-1	p.T203_splice						nuclear pore complex interacting protein family, member B15																		CTTTTTCAGATCCCCCCTTCTG	0.455													9	951	---	---	---	---					
CFDP1	10428	broad.mit.edu	37	16	75446448	75446449	+	Frame_Shift_Ins	INS	-	-	G			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr16:75446448_75446449insG	ENST00000283882.3	-	3	518_519	c.386_387insC	c.(385-387)cagfs	p.Q129fs	CFDP1_ENST00000564286.1_5'UTR	NM_006324.2	NP_006315.1	Q9UEE9	CFDP1_HUMAN	craniofacial development protein 1	129	Glu-rich.				multicellular organismal development					endometrium(1)|kidney(1)|large_intestine(1)|lung(1)|upper_aerodigestive_tract(1)	5						CTTGTGTACTTGGGGGCACTTT	0.455													11	1515	---	---	---	---					
TERF2IP	54386	broad.mit.edu	37	16	75690386	75690388	+	In_Frame_Del	DEL	TCC	TCC	-			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr16:75690386_75690388delTCC	ENST00000300086.4	+	3	1174_1176	c.1077_1079delTCC	c.(1075-1080)tac>ta	p.YP359del		NM_018975.3	NP_061848.2	Q9NYB0	TE2IP_HUMAN	telomeric repeat binding factor 2, interacting protein	359					negative regulation of DNA recombination at telomere|negative regulation of telomere maintenance|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|protection from non-homologous end joining at telomere|protein localization to chromosome, telomeric region|regulation of double-strand break repair via homologous recombination|telomere maintenance via telomerase|transcription, DNA-dependent	cytoplasm|nuclear telomere cap complex|nucleoplasm	DNA binding|protein binding			central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(1)	5						CTGATGGATATCCCATTTGGTCC	0.453													10	529	---	---	---	---					
TLDC1	57707	broad.mit.edu	37	16	84514302	84514303	+	Frame_Shift_Ins	INS	-	-	C			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr16:84514302_84514303insC	ENST00000343629.6	-	7	1271_1272	c.1089_1090insG	c.(1087-1092)ggagcafs	p.A364fs	TLDC1_ENST00000535580.1_Frame_Shift_Ins_p.A337fs	NM_020947.3	NP_065998.3			TBC/LysM-associated domain containing 1																		TAATTGTGCTGCCCCCCCATAC	0.550													10	122	---	---	---	---					
PRPF8	10594	broad.mit.edu	37	17	1565283	1565284	+	Frame_Shift_Ins	INS	-	-	G	rs35169383	byFrequency	TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr17:1565283_1565284insG	ENST00000572621.1	-	24	4203_4204	c.3938_3939insC	c.(3937-3939)cgtfs	p.R1313fs	PRPF8_ENST00000304992.6_Frame_Shift_Ins_p.R1313fs			Q6P2Q9	PRP8_HUMAN	pre-mRNA processing factor 8	1313						catalytic step 2 spliceosome|nuclear speck|U5 snRNP	protein binding|RNA binding			NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(13)|lung(24)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(5)|urinary_tract(3)	77				UCEC - Uterine corpus endometrioid carcinoma (25;0.0855)		AGAACACAACCGGGGGGAACCG	0.525													7	299	---	---	---	---					
CAMTA2	23125	broad.mit.edu	37	17	4875737	4875738	+	Frame_Shift_Ins	INS	-	-	G	rs145218609		TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr17:4875737_4875738insG	ENST00000361571.5	-	15	3005_3006	c.2594_2595insC	c.(2593-2595)cgcfs	p.R865fs	CAMTA2_ENST00000414043.3_Frame_Shift_Ins_p.R889fs|CAMTA2_ENST00000358183.4_Frame_Shift_Ins_p.R866fs|CAMTA2_ENST00000381311.5_Frame_Shift_Ins_p.R868fs|CAMTA2_ENST00000572543.1_Frame_Shift_Ins_p.R871fs|CAMTA2_ENST00000348066.3_Frame_Shift_Ins_p.R866fs	NM_001171168.1	NP_001164639.1	O94983	CMTA2_HUMAN	calmodulin binding transcription activator 2	866					cardiac muscle hypertrophy in response to stress|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	calmodulin binding|chromatin binding|histone deacetylase binding|transcription factor binding			breast(2)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(6)|lung(5)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	31						GCAGAGGTGCAGGGGGGGGACT	0.614													8	71	---	---	---	---					
CAMTA2	23125	broad.mit.edu	37	17	4884523	4884524	+	Frame_Shift_Ins	INS	-	-	C			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr17:4884523_4884524insC	ENST00000361571.5	-	7	1104_1105	c.693_694insG	c.(691-696)ggttggfs	p.W232fs	CAMTA2_ENST00000414043.3_Frame_Shift_Ins_p.W256fs|CAMTA2_ENST00000358183.4_Frame_Shift_Ins_p.W233fs|CAMTA2_ENST00000381311.5_Frame_Shift_Ins_p.W235fs|CAMTA2_ENST00000572543.1_Frame_Shift_Ins_p.W238fs|CAMTA2_ENST00000348066.3_Frame_Shift_Ins_p.W233fs	NM_001171168.1	NP_001164639.1	O94983	CMTA2_HUMAN	calmodulin binding transcription activator 2	233					cardiac muscle hypertrophy in response to stress|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	calmodulin binding|chromatin binding|histone deacetylase binding|transcription factor binding			breast(2)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(6)|lung(5)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	31						AACTTACCAAGCCCCCCACTGC	0.550											OREG0024111	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	7	594	---	---	---	---					
WSCD1	23302	broad.mit.edu	37	17	6012978	6012979	+	Frame_Shift_Ins	INS	-	-	C	rs41314099	byFrequency	TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr17:6012978_6012979insC	ENST00000574946.1	+	6	1291_1292	c.901_902insC	c.(901-903)cccfs	p.P301fs	WSCD1_ENST00000539421.1_Frame_Shift_Ins_p.P301fs|WSCD1_ENST00000573634.1_Frame_Shift_Ins_p.P185fs|WSCD1_ENST00000317744.5_Frame_Shift_Ins_p.P301fs|WSCD1_ENST00000574232.1_Frame_Shift_Ins_p.P301fs			Q658N2	WSCD1_HUMAN	WSC domain containing 1	301	WSC 2.					integral to membrane	sulfotransferase activity			breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(14)|ovary(1)|prostate(1)	35						TGCTTACCCTACCCCCCGGTTC	0.564													7	1259	---	---	---	---					
ALOX12	239	broad.mit.edu	37	17	6903739	6903740	+	Frame_Shift_Ins	INS	-	-	C			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr17:6903739_6903740insC	ENST00000251535.6	+	7	945_946	c.892_893insC	c.(892-894)cccfs	p.P298fs	AC027763.2_ENST00000574377.1_Intron|RP11-589P10.7_ENST00000572547.1_RNA|AC027763.2_ENST00000575727.1_Intron|AC027763.2_ENST00000399541.2_Intron	NM_000697.2	NP_000688.2	P18054	LOX12_HUMAN	arachidonate 12-lipoxygenase	298	Lipoxygenase.		A -> T.		anti-apoptosis|cellular component movement|fatty acid oxidation|leukotriene biosynthetic process|positive regulation of cell adhesion|positive regulation of cell growth|positive regulation of cell proliferation|superoxide anion generation	cytosol|sarcolemma	arachidonate 12-lipoxygenase activity|hepoxilin-epoxide hydrolase activity|iron ion binding|lipoxygenase activity|protein binding			breast(2)|central_nervous_system(1)|endometrium(3)|large_intestine(4)|lung(4)|ovary(1)|prostate(3)|urinary_tract(1)	19						ATACCTGGCTGCCCCCCTCGTT	0.554													7	982	---	---	---	---					
PLSCR3	57048	broad.mit.edu	37	17	7294058	7294059	+	Frame_Shift_Ins	INS	-	-	C			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr17:7294058_7294059insC	ENST00000535512.1	-	10	1742_1743	c.725_726insG	c.(724-726)gctfs	p.A242fs	PLSCR3_ENST00000324822.11_Frame_Shift_Ins_p.A242fs|PLSCR3_ENST00000576362.1_Frame_Shift_Ins_p.A218fs|PLSCR3_ENST00000576201.1_Frame_Shift_Ins_p.A242fs|C17orf61-PLSCR3_ENST00000573331.1_3'UTR|PLSCR3_ENST00000574401.1_Frame_Shift_Ins_p.A242fs			Q9NRY6	PLS3_HUMAN	phospholipid scramblase 3	242					phospholipid scrambling	integral to membrane|plasma membrane	calcium ion binding|calcium-dependent protein binding|phospholipid scramblase activity|SH3 domain binding			endometrium(1)|kidney(2)|urinary_tract(1)	4		Prostate(122;0.173)				CTCGGACCAGGCCCCCCCACTG	0.614													16	411	---	---	---	---					
TP53	7157	broad.mit.edu	37	17	7579470	7579471	+	Frame_Shift_Ins	INS	-	-	G	rs56275308		TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr17:7579470_7579471insG	ENST00000420246.2	-	4	348_349	c.216_217insC	c.(214-219)cctggcfs	p.G73fs	TP53_ENST00000413465.2_Frame_Shift_Ins_p.G73fs|TP53_ENST00000359597.4_Frame_Shift_Ins_p.G73fs|TP53_ENST00000269305.4_Frame_Shift_Ins_p.G73fs|TP53_ENST00000455263.2_Frame_Shift_Ins_p.G73fs|TP53_ENST00000445888.2_Frame_Shift_Ins_p.G73fs	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	73	Interaction with HRMT1L2.|Interaction with WWOX.		V -> E (in a sporadic cancer; somatic mutation).|V -> L (in sporadic cancers; somatic mutation).|V -> M (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.V73fs*76(11)|p.0?(8)|p.V73L(3)|p.G59fs*23(3)|p.R72fs*51(2)|p.V73M(2)|p.V73fs*9(1)|p.R65fs*38(1)|p.E68fs*76(1)|p.V73fs*50(1)|p.D48fs*55(1)|p.P13fs*18(1)|p.S33fs*23(1)|p.D57_A76del20(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GCAGGGGCCACGGGGGGAGCAG	0.604		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			7	623	---	---	---	---					
WRAP53	55135	broad.mit.edu	37	17	7606714	7606715	+	Frame_Shift_Ins	INS	-	-	G	rs146634933		TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr17:7606714_7606715insG	ENST00000316024.5	+	10	3905_3906	c.1557_1558insG	c.(1555-1560)tgggggfs	p.WG519fs	WRAP53_ENST00000534050.1_Frame_Shift_Ins_p.WG486fs|WRAP53_ENST00000457584.2_Frame_Shift_Ins_p.WG519fs|WRAP53_ENST00000396463.2_Frame_Shift_Ins_p.WG519fs|WRAP53_ENST00000431639.2_Frame_Shift_Ins_p.WG519fs			Q9BUR4	WAP53_HUMAN	WD repeat containing, antisense to TP53	519					positive regulation of telomerase activity|telomere formation via telomerase	Cajal body|cytoplasm|telomerase holoenzyme complex	protein binding|RNA binding			endometrium(4)|kidney(1)|large_intestine(2)|lung(7)|prostate(2)|stomach(2)	18						TCTGGTGGTGTGGGGGGGCGCC	0.599													11	104	---	---	---	---					
MYOCD	93649	broad.mit.edu	37	17	12655969	12655970	+	Frame_Shift_Ins	INS	-	-	C			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr17:12655969_12655970insC	ENST00000425538.1	+	10	1564_1565	c.1364_1365insC	c.(1363-1365)accfs	p.T455fs	MYOCD_ENST00000343344.4_Frame_Shift_Ins_p.T455fs|MYOCD_ENST00000395988.1_Frame_Shift_Ins_p.T359fs	NM_001146312.1|NM_153604.2	NP_001139784.1|NP_705832.1	Q8IZQ8	MYCD_HUMAN	myocardin	455	Ser-rich.				cardiac muscle cell differentiation|negative regulation of cell proliferation|negative regulation of cyclin-dependent protein kinase activity|positive regulation of smooth muscle cell differentiation|positive regulation of smooth muscle contraction|positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation|regulation of histone acetylation|smooth muscle cell differentiation	nucleus	nucleic acid binding|RNA polymerase II transcription factor binding transcription factor activity|transcription factor binding			breast(2)|central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(11)|liver(2)|lung(33)|ovary(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	70				UCEC - Uterine corpus endometrioid carcinoma (92;0.0969)		ACCAGCTCCAGCCCCCCGATCT	0.614													7	230	---	---	---	---					
SLC47A1	55244	broad.mit.edu	37	17	19459097	19459098	+	Frame_Shift_Ins	INS	-	-	C			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr17:19459097_19459098insC	ENST00000571335.1	+	7	563_564	c.143_144insC	c.(142-144)gccfs	p.A48fs	SLC47A1_ENST00000457293.1_Intron|SLC47A1_ENST00000395585.1_Intron|SLC47A1_ENST00000542886.1_Intron|SLC47A1_ENST00000436810.2_Intron|SLC47A1_ENST00000270570.4_Intron|SLC47A1_ENST00000575023.1_Intron			Q96FL8	S47A1_HUMAN	solute carrier family 47 (multidrug and toxin extrusion), member 1	0						integral to membrane|plasma membrane	drug:hydrogen antiporter activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(4)|lung(5)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(1)	23	all_cancers(12;2.49e-05)|all_epithelial(12;0.00263)|Hepatocellular(7;0.00345)					AATGTGTGTGTCCCCCCCACAG	0.599													8	93	---	---	---	---					
FAM222B	55731	broad.mit.edu	37	17	27086257	27086258	+	Frame_Shift_Ins	INS	-	-	G			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr17:27086257_27086258insG	ENST00000341217.5	-	3	934_935	c.719_720insC	c.(718-720)caafs	p.Q240fs	FAM222B_ENST00000581407.1_Frame_Shift_Ins_p.Q240fs|FAM222B_ENST00000582266.1_3'UTR|FAM222B_ENST00000452648.3_Frame_Shift_Ins_p.Q240fs	NM_018182.2	NP_060652.2	Q8WU58	CQ063_HUMAN	family with sequence similarity 222, member B	240																	CGGTCACATTCGGGGGGGCATC	0.619													10	62	---	---	---	---					
RAB11FIP4	84440	broad.mit.edu	37	17	29758897	29758898	+	Frame_Shift_Ins	INS	-	-	G			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr17:29758897_29758898insG	ENST00000325874.8	+	2	455_456	c.226_227insG	c.(226-228)gggfs	p.G76fs		NM_032932.3	NP_116321.2	Q86YS3	RFIP4_HUMAN	RAB11 family interacting protein 4 (class II)	76	EF-hand.				cytokinesis|interspecies interaction between organisms|protein transport	cleavage furrow|endocytic vesicle|midbody|recycling endosome membrane	ADP-ribosylation factor binding|calcium ion binding|protein homodimerization activity|Rab GTPase binding	p.?(1)		endometrium(2)|kidney(1)|large_intestine(5)|lung(3)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	19		all_cancers(10;3.62e-13)|all_epithelial(10;0.000387)|all_lung(9;0.0132)|Breast(31;0.014)|all_hematologic(16;0.015)|Myeloproliferative disorder(56;0.0255)|Acute lymphoblastic leukemia(14;0.0259)|Ovarian(249;0.0423)|Lung NSC(157;0.066)				GGACTTTTGCCGGGGGGTGTTC	0.579													7	300	---	---	---	---					
ASIC2	40	broad.mit.edu	37	17	31439004	31439005	+	Frame_Shift_Ins	INS	-	-	C			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr17:31439004_31439005insC	ENST00000225823.2	-	2	1661_1662	c.789_790insG	c.(787-792)ggcaggfs	p.R264fs	RP11-40A13.1_ENST00000584688.1_RNA|ASIC2_ENST00000448983.1_5'UTR|ASIC2_ENST00000359872.6_Frame_Shift_Ins_p.R213fs	NM_183377.1	NP_899233.1	Q16515	ACCN1_HUMAN	acid-sensing (proton-gated) ion channel 2	213					central nervous system development|peripheral nervous system development|synaptic transmission	integral to plasma membrane	ligand-gated sodium channel activity|protein binding									Amiloride(DB00594)	CCGTTGCCTGTCCCCCCCTTGA	0.550													8	244	---	---	---	---					
HNF1B	6928	broad.mit.edu	37	17	36059173	36059174	+	Frame_Shift_Ins	INS	-	-	G			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr17:36059173_36059174insG	ENST00000225893.4	-	8	1922_1923	c.1561_1562insC	c.(1561-1563)gtafs	p.V521fs	HNF1B_ENST00000427275.2_Intron|HNF1B_ENST00000561193.1_Frame_Shift_Ins_p.V495fs|HNF1B_ENST00000560016.1_Intron	NM_000458.2|NM_001165923.1	NP_000449.1|NP_001159395.1	P35680	HNF1B_HUMAN	HNF1 homeobox B	521					endocrine pancreas development|genitalia development|kidney development|positive regulation of transcription initiation from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|pronephric nephron tubule development|regulation of pronephros size	nucleus	DNA binding|protein homodimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|central_nervous_system(3)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(6)|kidney(3)|large_intestine(2)|liver(1)|lung(3)|ovary(3)|prostate(1)|skin(2)	28		Breast(25;0.00765)|Ovarian(249;0.15)	STAD - Stomach adenocarcinoma(1;0.0142)			GTGGGAATACTGGGGGGGTTCC	0.515													8	213	---	---	---	---					
PCGF2	7703	broad.mit.edu	37	17	36896586	36896587	+	Frame_Shift_Ins	INS	-	-	C			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr17:36896586_36896587insC	ENST00000580830.1	-	4	770_771	c.69_70insG	c.(67-72)ggacttfs	p.L24fs	PCGF2_ENST00000581345.1_Frame_Shift_Ins_p.L24fs|PCGF2_ENST00000585100.1_Frame_Shift_Ins_p.L24fs|PCGF2_ENST00000578109.1_Intron|PCGF2_ENST00000579882.1_Frame_Shift_Ins_p.L24fs|PCGF2_ENST00000360797.2_Frame_Shift_Ins_p.L24fs			P35227	PCGF2_HUMAN	polycomb group ring finger 2	24					negative regulation of transcription from RNA polymerase II promoter	PcG protein complex	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(4)|skin(1)	10	Breast(7;9.07e-22)					TCGATGAAGTACCCCCCGCAGA	0.629													7	388	---	---	---	---					
CDK12	51755	broad.mit.edu	37	17	37687471	37687472	+	Frame_Shift_Ins	INS	-	-	G			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr17:37687471_37687472insG	ENST00000447079.4	+	14	4408_4409	c.4375_4376insG	c.(4375-4377)gggfs	p.G1459fs	CDK12_ENST00000430627.2_Frame_Shift_Ins_p.G1450fs	NM_015083.1|NM_016507.2	NP_055898.1|NP_057591.2	Q9NYV4	CDK12_HUMAN	cyclin-dependent kinase 12	1459					mRNA processing|phosphorylation of RNA polymerase II C-terminal domain|protein autophosphorylation|regulation of MAP kinase activity|RNA splicing	nuclear cyclin-dependent protein kinase holoenzyme complex|nuclear speck|nucleolus	ATP binding|cyclin-dependent protein kinase activity|protein binding|RNA polymerase II carboxy-terminal domain kinase activity			NS(4)|breast(3)|endometrium(5)|kidney(4)|large_intestine(11)|lung(23)|ovary(11)|prostate(4)|skin(2)|urinary_tract(3)	70						AGGCCTTCACTGGGGGGGCCCA	0.559			"""Mis, N, F"""		serous ovarian					TCGA Ovarian(9;0.13)			8	154	---	---	---	---					
CNTNAP1	8506	broad.mit.edu	37	17	40843872	40843873	+	Frame_Shift_Ins	INS	-	-	C			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr17:40843872_40843873insC	ENST00000264638.4	+	16	2610_2611	c.2393_2394insC	c.(2392-2394)tccfs	p.S798fs	CTD-3193K9.3_ENST00000592440.1_RNA	NM_003632.2	NP_003623.1	P78357	CNTP1_HUMAN	contactin associated protein 1	798					axon guidance|cell adhesion	paranode region of axon	receptor activity|receptor binding|SH3 domain binding|SH3/SH2 adaptor activity			NS(1)|breast(4)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(11)|lung(15)|ovary(5)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	49		Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.143)		GCACTACGCTTCCCCCCAATCC	0.564													11	1274	---	---	---	---					
OSBPL7	114881	broad.mit.edu	37	17	45886342	45886343	+	Frame_Shift_Ins	INS	-	-	G	rs143462261		TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr17:45886342_45886343insG	ENST00000007414.3	-	21	2375_2376	c.2184_2185insC	c.(2182-2187)ccaccafs	p.P729fs	OSBPL7_ENST00000392507.3_Frame_Shift_Ins_p.P729fs	NM_145798.2	NP_665741.1	Q9BZF2	OSBL7_HUMAN	oxysterol binding protein-like 7	729					lipid transport		lipid binding	p.D729fs*3(1)		autonomic_ganglia(1)|endometrium(6)|kidney(2)|large_intestine(5)|liver(2)|lung(13)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	32						CGCTCATGGTCGGGGGGCATTG	0.619													14	425	---	---	---	---					
MARCH10	162333	broad.mit.edu	37	17	60814265	60814266	+	Frame_Shift_Ins	INS	-	-	C			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr17:60814265_60814266insC	ENST00000544856.2	-	7	1338_1339	c.960_961insG	c.(958-963)ggcatcfs	p.I321fs	MARCH10_ENST00000311269.5_Frame_Shift_Ins_p.I322fs|MARCH10_ENST00000456609.2_Frame_Shift_Ins_p.I322fs|MARCH10_ENST00000583600.1_Frame_Shift_Ins_p.I360fs|RP11-156L14.1_ENST00000582564.1_RNA|RP11-156L14.1_ENST00000577270.1_RNA			Q8NA82	MARHA_HUMAN	membrane-associated ring finger (C3HC4) 10, E3 ubiquitin protein ligase	322							ligase activity|zinc ion binding			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(11)|liver(1)|lung(15)	38						GGGGTCGATGTCCCCCCAAATC	0.460													9	1097	---	---	---	---					
ACE	1636	broad.mit.edu	37	17	61559936	61559937	+	Frame_Shift_Ins	INS	-	-	G	rs145172277	byFrequency	TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr17:61559936_61559937insG	ENST00000290866.4	+	8	1252_1253	c.1228_1229insG	c.(1228-1230)gggfs	p.G410fs	ACE_ENST00000428043.1_Frame_Shift_Ins_p.G410fs|ACE_ENST00000584529.1_3'UTR|ACE_ENST00000538928.1_Frame_Shift_Ins_p.G410fs	NM_000789.3	NP_000780.1	P12821	ACE_HUMAN	angiotensin I converting enzyme	410	Peptidase M2 1.				arachidonic acid secretion|hormone catabolic process|kidney development|peptide catabolic process|regulation of smooth muscle cell migration	endosome|external side of plasma membrane|extracellular space|integral to membrane|membrane fraction|plasma membrane	actin binding|bradykinin receptor binding|carboxypeptidase activity|chloride ion binding|drug binding|metallopeptidase activity|peptidyl-dipeptidase activity|zinc ion binding			autonomic_ganglia(1)|breast(2)|endometrium(5)|kidney(3)|large_intestine(3)|lung(22)|ovary(6)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	51					Benazepril(DB00542)|Captopril(DB01197)|Deserpidine(DB01089)|Enalapril(DB00584)|Fosinopril(DB00492)|Lisinopril(DB00722)|Moexipril(DB00691)|Perindopril(DB00790)|Quinapril(DB00881)|Ramipril(DB00178)|Rescinnamine(DB01180)|Spirapril(DB01348)|Trandolapril(DB00519)	CTCCCTGCGTCGGGGGGCCAAC	0.609													8	154	---	---	---	---					
ABCA6	23460	broad.mit.edu	37	17	67083603	67083604	+	Frame_Shift_Ins	INS	-	-	G			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr17:67083603_67083604insG	ENST00000284425.2	-	29	3883_3884	c.3709_3710insC	c.(3709-3711)aagfs	p.K1237fs	ABCA6_ENST00000446604.2_5'UTR	NM_080284.2	NP_525023.2	Q8N139	ABCA6_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 6	1237					transport	integral to membrane	ATP binding|ATPase activity			breast(6)|endometrium(5)|kidney(17)|large_intestine(18)|lung(20)|ovary(3)|prostate(2)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	82	Breast(10;5.65e-12)					ATCTCTACTTTGGGGGGAAATT	0.376													11	1076	---	---	---	---					
MUC16	94025	broad.mit.edu	37	19	9064309	9064310	+	Frame_Shift_Ins	INS	-	-	G			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr19:9064309_9064310insG	ENST00000397910.4	-	3	23339_23340	c.23136_23137insC	c.(23134-23139)ccctccfs	p.S7713fs		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	7715	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GGAAGGGGAGAGGGGGGGATAT	0.530													9	410	---	---	---	---					
MUC16	94025	broad.mit.edu	37	19	9072450	9072451	+	Frame_Shift_Ins	INS	-	-	G			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr19:9072450_9072451insG	ENST00000397910.4	-	3	15198_15199	c.14995_14996insC	c.(14995-14997)ggcfs	p.G4999fs		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	5001	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GATCCCTGCCTGGGGGGTTGTA	0.465													9	416	---	---	---	---					
DNMT1	1786	broad.mit.edu	37	19	10291083	10291084	+	Frame_Shift_Ins	INS	-	-	G			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr19:10291083_10291084insG	ENST00000340748.4	-	4	622_623	c.387_388insC	c.(385-390)ccaaccfs	p.T130fs	DNMT1_ENST00000540357.1_Frame_Shift_Ins_p.T130fs|DNMT1_ENST00000359526.4_Frame_Shift_Ins_p.T130fs			P26358	DNMT1_HUMAN	DNA (cytosine-5-)-methyltransferase 1	130	Interaction with DNMT3A.|Interaction with the PRC2/EED-EZH2 complex (By similarity).				chromatin modification|maintenance of DNA methylation|negative regulation of histone H3-K9 methylation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of gene expression|positive regulation of histone H3-K4 methylation|transcription, DNA-dependent	nucleus	DNA (cytosine-5-)-methyltransferase activity|DNA binding|transcription factor binding			breast(5)|endometrium(8)|kidney(5)|large_intestine(21)|lung(11)|ovary(2)|pancreas(1)|prostate(10)|skin(5)|stomach(1)|urinary_tract(1)	70			OV - Ovarian serous cystadenocarcinoma(20;1.59e-09)|Epithelial(33;2.86e-06)|all cancers(31;6.68e-06)		Azacitidine(DB00928)|Decitabine(DB01262)|Flucytosine(DB01099)|Ifosfamide(DB01181)|Procainamide(DB01035)	GAAAGGGGTTTGGGGGGGCTGT	0.495													17	215	---	---	---	---					
ZNF878	729747	broad.mit.edu	37	19	12155624	12155625	+	Frame_Shift_Ins	INS	-	-	T			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr19:12155624_12155625insT	ENST00000602107.1	-	5	731_732	c.732_733insA	c.(730-735)aacctafs	p.NL244fs	CTD-2006C1.2_ENST00000591838.1_RNA|CTD-2006C1.2_ENST00000476474.1_RNA|ZNF878_ENST00000547628.1_Frame_Shift_Ins_p.NL197fs|CTD-2006C1.10_ENST00000547473.1_Intron|CTD-2006C1.2_ENST00000591898.1_RNA			C9JN71	ZN878_HUMAN	zinc finger protein 878	197					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			cervix(1)|endometrium(1)|kidney(1)|lung(4)|urinary_tract(1)	8						CATTCATAGGGTTTTTTTGCAG	0.396													11	580	---	---	---	---					
NOTCH3	4854	broad.mit.edu	37	19	15276860	15276861	+	Frame_Shift_Ins	INS	-	-	C			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr19:15276860_15276861insC	ENST00000263388.2	-	30	5479_5480	c.5404_5405insG	c.(5404-5406)tctfs	p.S1802fs		NM_000435.2	NP_000426.2	Q9UM47	NOTC3_HUMAN	notch 3	1802					Notch receptor processing|Notch signaling pathway|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			breast(4)|central_nervous_system(3)|endometrium(10)|kidney(3)|large_intestine(16)|liver(1)|lung(31)|ovary(8)|prostate(3)|skin(7)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	93			OV - Ovarian serous cystadenocarcinoma(3;2.6e-20)|Epithelial(3;1.34e-16)|all cancers(3;5.13e-15)			TGGCTCCAGAGCCCCCCCACAG	0.569													8	240	---	---	---	---					
CPAMD8	27151	broad.mit.edu	37	19	17039883	17039884	+	Frame_Shift_Ins	INS	-	-	C			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr19:17039883_17039884insC	ENST00000443236.1	-	24	3184_3185	c.3153_3154insG	c.(3151-3156)ggatcafs	p.S1052fs		NM_015692.2	NP_056507.2	Q8IZJ3	CPMD8_HUMAN	C3 and PZP-like, alpha-2-macroglobulin domain containing 8	1005						extracellular space|plasma membrane	serine-type endopeptidase inhibitor activity	p.H1052fs*30(1)		breast(11)|central_nervous_system(3)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(17)|lung(14)|ovary(7)|pancreas(2)|prostate(4)|skin(5)	82						GTGTTCTGATGCCCCCCCAGGA	0.584													7	99	---	---	---	---					
TSHZ3	57616	broad.mit.edu	37	19	31769141	31769142	+	Frame_Shift_Ins	INS	-	-	C			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr19:31769141_31769142insC	ENST00000240587.4	-	2	1884_1885	c.1557_1558insG	c.(1555-1560)ggttgafs	p.*520fs		NM_020856.2	NP_065907.2	Q63HK5	TSH3_HUMAN	teashirt zinc finger homeobox 3	520					negative regulation of transcription, DNA-dependent|regulation of respiratory gaseous exchange by neurological system process	growth cone|nucleus	chromatin binding|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(4)|endometrium(15)|kidney(9)|large_intestine(20)|lung(60)|ovary(4)|pancreas(2)|prostate(4)|skin(5)	123	Esophageal squamous(110;0.226)					AGGATATCAAGCCCCCCCTTGG	0.500													20	532	---	---	---	---					
FBL	2091	broad.mit.edu	37	19	40325192	40325193	+	Frame_Shift_Ins	INS	-	-	G			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr19:40325192_40325193insG	ENST00000221801.3	-	9	1064_1065	c.951_952insC	c.(949-954)ccaggtfs	p.G318fs	FBL_ENST00000593503.1_5'UTR	NM_001436.3	NP_001427.2	P22087	FBRL_HUMAN	fibrillarin	318					rRNA processing|tRNA processing	box C/D snoRNP complex|Cajal body	methyltransferase activity|protein binding|RNA binding			endometrium(1)|kidney(1)|large_intestine(4)|lung(2)|ovary(1)	9	all_cancers(60;5.79e-06)|all_lung(34;5.2e-08)|Lung NSC(34;6.14e-08)|Ovarian(47;0.06)	Renal(1328;0.000518)|Hepatocellular(1079;0.0893)	Epithelial(26;5.74e-25)|OV - Ovarian serous cystadenocarcinoma(5;3.13e-24)|all cancers(26;8.59e-23)	GBM - Glioblastoma multiforme(1328;0.000826)|STAD - Stomach adenocarcinoma(1328;0.138)		TTCTTCACCTTGGGGGGTGGCC	0.505													9	497	---	---	---	---					
AXL	558	broad.mit.edu	37	19	41743932	41743933	+	Frame_Shift_Ins	INS	-	-	C			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr19:41743932_41743933insC	ENST00000301178.4	+	7	1057_1058	c.867_868insC	c.(865-870)gtccccfs	p.VP289fs	AXL_ENST00000593513.1_Frame_Shift_Ins_p.VP21fs|AXL_ENST00000359092.3_Frame_Shift_Ins_p.VP289fs	NM_001278599.1|NM_021913.3	NP_001265528.1|NP_068713.2	P30530	UFO_HUMAN	AXL receptor tyrosine kinase	289	Fibronectin type-III 1.					integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity			breast(3)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(9)|lung(12)|ovary(3)|pancreas(1)|prostate(4)|skin(3)|stomach(3)|upper_aerodigestive_tract(1)	48						AAGCATCCGTGCCCCCCCATCA	0.649													11	396	---	---	---	---					
MEGF8	1954	broad.mit.edu	37	19	42838297	42838298	+	Frame_Shift_Ins	INS	-	-	G			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr19:42838297_42838298insG	ENST00000334370.4	+	3	1125_1126	c.490_491insG	c.(490-492)gggfs	p.G164fs	MEGF8_ENST00000251268.6_Frame_Shift_Ins_p.G164fs	NM_001410.2	NP_001401.2	Q7Z7M0	MEGF8_HUMAN	multiple EGF-like-domains 8	164	EGF-like 1.					integral to membrane	calcium ion binding|structural molecule activity			breast(2)|cervix(1)|endometrium(11)|kidney(2)|large_intestine(9)|lung(20)|ovary(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	50		Prostate(69;0.00682)				CGAGCCGGGCTGGGGGGGTCCT	0.703													7	169	---	---	---	---					
MARK4	57787	broad.mit.edu	37	19	45805663	45805664	+	Frame_Shift_Ins	INS	-	-	C			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr19:45805663_45805664insC	ENST00000300843.4	+	18	2331_2332	c.2034_2035insC	c.(2032-2037)ccccccfs	p.PP678fs	MARK4_ENST00000262891.4_Frame_Shift_Ins_p.P652fs	NM_031417.3	NP_113605.2	Q96L34	MARK4_HUMAN	MAP/microtubule affinity-regulating kinase 4	0					microtubule bundle formation|nervous system development|positive regulation of programmed cell death	centrosome|neuron projection	ATP binding|gamma-tubulin binding|microtubule binding|protein serine/threonine kinase activity|tau-protein kinase activity|ubiquitin binding			NS(1)|biliary_tract(1)|central_nervous_system(4)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(6)|lung(7)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	31		all_neural(266;0.224)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.0102)		AACGGAAACCGCCCCCCGGCTG	0.639													9	444	---	---	---	---					
HRC	3270	broad.mit.edu	37	19	49657097	49657098	+	Frame_Shift_Ins	INS	-	-	G			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr19:49657097_49657098insG	ENST00000252825.4	-	1	1583_1584	c.1397_1398insC	c.(1396-1398)cggfs	p.R466fs	HRC_ENST00000595625.1_Frame_Shift_Ins_p.R466fs	NM_002152.2	NP_002143.1	P23327	SRCH_HUMAN	histidine rich calcium binding protein	466					muscle contraction	sarcoplasmic reticulum lumen	calcium ion binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(10)|lung(10)|ovary(1)|prostate(3)|urinary_tract(2)	34		all_lung(116;3.16e-06)|Lung NSC(112;6.25e-06)|all_neural(266;0.0189)|Ovarian(192;0.0392)		all cancers(93;2.01e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.00019)|GBM - Glioblastoma multiforme(486;0.00279)|Epithelial(262;0.00622)		CTGTGTGTCCTGGGGGGTGATG	0.550													10	554	---	---	---	---					
TSKS	60385	broad.mit.edu	37	19	50243063	50243064	+	Frame_Shift_Ins	INS	-	-	G			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr19:50243063_50243064insG	ENST00000246801.3	-	11	1830_1831	c.1748_1749insC	c.(1747-1749)caafs	p.Q583fs	TSKS_ENST00000358830.3_Frame_Shift_Ins_p.Q383fs	NM_021733.1	NP_068379.1	Q9UJT2	TSKS_HUMAN	testis-specific serine kinase substrate	583							protein binding			breast(3)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(12)|liver(1)|lung(9)|prostate(3)|skin(3)	38		all_lung(116;3.24e-07)|Lung NSC(112;1.6e-06)|all_neural(266;0.0459)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.00153)|GBM - Glioblastoma multiforme(134;0.0145)		CCCCCTGTTTTGGGGGGGTTCC	0.545													14	418	---	---	---	---					
TSKS	60385	broad.mit.edu	37	19	50243087	50243088	+	Frame_Shift_Ins	INS	-	-	C			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr19:50243087_50243088insC	ENST00000246801.3	-	11	1806_1807	c.1724_1725insG	c.(1723-1725)gggfs	p.G575fs	TSKS_ENST00000358830.3_Frame_Shift_Ins_p.G375fs	NM_021733.1	NP_068379.1	Q9UJT2	TSKS_HUMAN	testis-specific serine kinase substrate	575							protein binding			breast(3)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(12)|liver(1)|lung(9)|prostate(3)|skin(3)	38		all_lung(116;3.24e-07)|Lung NSC(112;1.6e-06)|all_neural(266;0.0459)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.00153)|GBM - Glioblastoma multiforme(134;0.0145)		CACTGCTGCCTCCCCCCATTGT	0.554													7	544	---	---	---	---					
ZNF600	162966	broad.mit.edu	37	19	53270877	53270877	+	Frame_Shift_Del	DEL	A	A	-			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr19:53270877delA	ENST00000338230.3	-	3	399	c.132delT	c.(130-132)atfs	p.I44fs		NM_198457.2	NP_940859.2	Q6ZNG1	ZN600_HUMAN	zinc finger protein 600	44					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(2)|kidney(4)|large_intestine(9)|liver(1)|lung(10)|prostate(1)|upper_aerodigestive_tract(1)	30				OV - Ovarian serous cystadenocarcinoma(262;0.0241)|GBM - Glioblastoma multiforme(134;0.0404)		ACTGAAACTCAATATCATGAA	0.378													249	564	---	---	---	---					
KIR2DL3	3804	broad.mit.edu	37	19	55263920	55263921	+	Frame_Shift_Ins	INS	-	-	C			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr19:55263920_55263921insC	ENST00000342376.3	+	8	1006_1007	c.975_976insC	c.(973-978)acccccfs	p.TP325fs	CTB-61M7.1_ENST00000400864.3_RNA|KIR3DL1_ENST00000402254.2_Intron|KIR3DL1_ENST00000541392.1_Intron|KIR3DL1_ENST00000538269.1_Intron|KIR2DL3_ENST00000434419.2_Intron|KIR2DL4_ENST00000396284.2_Intron	NM_015868.2	NP_056952.2			killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 3											breast(1)|cervix(1)|large_intestine(1)|lung(11)|ovary(3)|pancreas(1)|skin(2)|urinary_tract(1)	21				GBM - Glioblastoma multiforme(193;0.0192)		GGCCCAAGACACCCCCAACAGA	0.505													8	1169	---	---	---	---					
NRSN2	80023	broad.mit.edu	37	20	333922	333923	+	Frame_Shift_Ins	INS	-	-	C			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr20:333922_333923insC	ENST00000382291.3	+	4	498_499	c.258_259insC	c.(256-261)gtccccfs	p.VP86fs	NRSN2_ENST00000492242.1_3'UTR|NRSN2_ENST00000382285.2_Frame_Shift_Ins_p.VP86fs	NM_024958.2	NP_079234.1	Q9GZP1	NRSN2_HUMAN	neurensin 2	86						integral to membrane|plasma membrane|transport vesicle				endometrium(1)|large_intestine(2)|lung(4)|urinary_tract(1)	8		all_cancers(10;0.0834)				GCTATGCAGTGCCCCCCAAGCT	0.644													13	406	---	---	---	---					
FASTKD5	60493	broad.mit.edu	37	20	3128000	3128001	+	Frame_Shift_Ins	INS	-	-	C			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr20:3128000_3128001insC	ENST00000380266.3	-	2	2037_2038	c.1716_1717insG	c.(1714-1719)ggcccafs	p.GP572fs	UBOX5_ENST00000217173.2_Intron|UBOX5-AS1_ENST00000446537.1_RNA|UBOX5_ENST00000348031.2_Intron	NM_021826.4	NP_068598.1	Q7L8L6	FAKD5_HUMAN	FAST kinase domains 5	572					apoptosis|cellular respiration	mitochondrion	ATP binding|protein kinase activity			breast(2)|endometrium(2)|large_intestine(2)|lung(8)|prostate(2)|skin(1)|urinary_tract(2)	19						ACGTACTGGGGCCCCCCCAGCA	0.436													8	165	---	---	---	---					
SMOX	54498	broad.mit.edu	37	20	4163027	4163028	+	Frame_Shift_Ins	INS	-	-	G	rs145014650	by1000genomes	TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr20:4163027_4163028insG	ENST00000305958.4	+	5	1126_1127	c.901_902insG	c.(901-903)gggfs	p.G301fs	SMOX_ENST00000379460.2_Frame_Shift_Ins_p.G301fs|SMOX_ENST00000346595.2_Intron|SMOX_ENST00000278795.3_Intron|SMOX_ENST00000339123.6_Intron	NM_175839.1	NP_787033.1	Q9NWM0	SMOX_HUMAN	spermine oxidase	301			R -> P (in dbSNP:rs6084654).		polyamine biosynthetic process|xenobiotic metabolic process	cytosol|nucleus	polyamine oxidase activity	p.R301W(1)		breast(1)|cervix(1)|endometrium(8)|kidney(1)|large_intestine(7)|lung(5)|skin(2)|urinary_tract(1)	26					Spermine(DB00127)	AGAGGAGCCCCGGGGGGGCAGG	0.673													7	119	---	---	---	---					
CST4	1472	broad.mit.edu	37	20	23667825	23667826	+	Frame_Shift_Ins	INS	-	-	C	rs140501583		TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr20:23667825_23667826insC	ENST00000217423.3	-	2	311_312	c.241_242insG	c.(241-243)gaafs	p.E81fs		NM_001899.2	NP_001890.1	P01036	CYTS_HUMAN	cystatin S	81						extracellular region	cysteine-type endopeptidase inhibitor activity			breast(1)|endometrium(1)|large_intestine(2)|lung(10)|skin(1)|upper_aerodigestive_tract(1)	16	Lung NSC(19;0.0789)|Colorectal(13;0.0993)|all_lung(19;0.169)					GAAGTAATTCACCCCCCCAAAG	0.554													19	438	---	---	---	---					
TM9SF4	9777	broad.mit.edu	37	20	30737490	30737491	+	Frame_Shift_Ins	INS	-	-	C			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr20:30737490_30737491insC	ENST00000217315.5	+	10	1297_1298	c.957_958insC	c.(955-960)agccccfs	p.SP319fs	TM9SF4_ENST00000398022.2_Frame_Shift_Ins_p.SP336fs			Q92544	TM9S4_HUMAN	transmembrane 9 superfamily protein member 4	336						integral to membrane				central_nervous_system(2)|kidney(1)|large_intestine(4)|lung(8)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	20			UCEC - Uterine corpus endometrioid carcinoma (5;0.0241)			ACGTCTTCAGGCCCCCCCAGTA	0.604													8	128	---	---	---	---					
DNMT3B	1789	broad.mit.edu	37	20	31384650	31384651	+	Frame_Shift_Ins	INS	-	-	G			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr20:31384650_31384651insG	ENST00000328111.2	+	13	1673_1674	c.1352_1353insG	c.(1351-1353)gggfs	p.G451fs	DNMT3B_ENST00000375623.4_Stop_Codon_Ins|DNMT3B_ENST00000348286.2_Frame_Shift_Ins_p.G431fs|DNMT3B_ENST00000344505.4_Frame_Shift_Ins_p.G431fs|DNMT3B_ENST00000353855.2_Frame_Shift_Ins_p.G431fs|DNMT3B_ENST00000456297.2_Frame_Shift_Ins_p.G355fs|DNMT3B_ENST00000201963.3_Frame_Shift_Ins_p.G443fs|DNMT3B_ENST00000443239.3_Frame_Shift_Ins_p.G389fs	NM_006892.3	NP_008823.1	Q9UBC3	DNM3B_HUMAN	DNA (cytosine-5-)-methyltransferase 3 beta	451	ADD.|Interaction with the PRC2/EED-EZH2 complex (By similarity).				negative regulation of histone H3-K9 methylation|positive regulation of gene expression|positive regulation of histone H3-K4 methylation		metal ion binding|protein binding|transcription corepressor activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(16)|ovary(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	39						CCTCTCTTTGAGGGGGGGCTCT	0.559													18	262	---	---	---	---					
RALGAPB	57148	broad.mit.edu	37	20	37146232	37146233	+	Frame_Shift_Ins	INS	-	-	C			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr20:37146232_37146233insC	ENST00000262879.6	+	8	1419_1420	c.1135_1136insC	c.(1135-1137)cccfs	p.P379fs	RALGAPB_ENST00000397038.1_Frame_Shift_Ins_p.P157fs|RALGAPB_ENST00000397042.3_Frame_Shift_Ins_p.P379fs|RALGAPB_ENST00000397040.1_Frame_Shift_Ins_p.P379fs|RALGAPB_ENST00000537204.1_Frame_Shift_Ins_p.P379fs			Q86X10	RLGPB_HUMAN	Ral GTPase activating protein, beta subunit (non-catalytic)	379					activation of Ral GTPase activity	intracellular	protein heterodimerization activity|Ral GTPase activator activity	p.H382fs*2(1)		breast(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(8)|lung(29)|ovary(1)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	65						TGTCAGTACCACCCCCCCACAT	0.446													9	195	---	---	---	---					
LPIN3	64900	broad.mit.edu	37	20	39977798	39977799	+	Frame_Shift_Ins	INS	-	-	C			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr20:39977798_39977799insC	ENST00000373257.3	+	5	715_716	c.624_625insC	c.(622-627)tgccccfs	p.CP208fs		NM_022896.1	NP_075047.1	Q9BQK8	LPIN3_HUMAN	lipin 3	208					fatty acid metabolic process	nucleus	phosphatidate phosphatase activity			breast(2)|central_nervous_system(1)|cervix(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|liver(2)|lung(7)|ovary(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	31		Myeloproliferative disorder(115;0.000739)				ATGGCGAGTGGCCCCCCCAGGC	0.540													8	192	---	---	---	---					
SLPI	6590	broad.mit.edu	37	20	43881730	43881731	+	Frame_Shift_Ins	INS	-	-	G			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr20:43881730_43881731insG	ENST00000338380.2	-	3	326_327	c.306_307insC	c.(304-309)ccatttfs	p.F103fs		NM_003064.2	NP_003055.1	P03973	SLPI_HUMAN	secretory leukocyte peptidase inhibitor	103	Elastase inhibitory domain.|WAP 2.					extracellular region	serine-type endopeptidase inhibitor activity			lung(3)|ovary(1)	4		Myeloproliferative disorder(115;0.0122)				TCACAGAAATTGGGGGGGTTAA	0.535													12	388	---	---	---	---					
EYA2	2139	broad.mit.edu	37	20	45771755	45771757	+	In_Frame_Del	DEL	GCA	GCA	-			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr20:45771755_45771757delGCA	ENST00000327619.5	+	10	1320_1322	c.946_948delGCA	c.(946-948)del	p.A316del	EYA2_ENST00000317304.6_Intron|EYA2_ENST00000357410.3_In_Frame_Del_p.A316del	NM_005244.4	NP_005235.3	O00167	EYA2_HUMAN	eyes absent homolog 2 (Drosophila)	316					DNA repair|histone dephosphorylation|mesodermal cell fate specification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	magnesium ion binding|protein binding|protein tyrosine phosphatase activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(7)|lung(11)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	32		Myeloproliferative disorder(115;0.0241)				CTTCAACCTTGCAGATACACATC	0.468													24	157	---	---	---	---					
KCNB1	3745	broad.mit.edu	37	20	47989771	47989772	+	Frame_Shift_Ins	INS	-	-	G			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr20:47989771_47989772insG	ENST00000371741.4	-	2	2491_2492	c.2325_2326insC	c.(2323-2328)ccaaagfs	p.PK775fs		NM_004975.2	NP_004966.1	Q14721	KCNB1_HUMAN	potassium voltage-gated channel, Shab-related subfamily, member 1	775					energy reserve metabolic process|regulation of insulin secretion	voltage-gated potassium channel complex	protein binding|voltage-gated potassium channel activity			central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(8)|liver(1)|lung(22)|pancreas(2)|prostate(7)|skin(4)|stomach(1)|urinary_tract(1)	53			BRCA - Breast invasive adenocarcinoma(12;0.000405)|COAD - Colon adenocarcinoma(4;0.14)|Colorectal(8;0.166)			GGGAGGCTTTTGGGGGGGCTGG	0.545													42	929	---	---	---	---					
KCNB1	3745	broad.mit.edu	37	20	47989890	47989891	+	Frame_Shift_Ins	INS	-	-	G	rs151175979	by1000genomes	TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr20:47989890_47989891insG	ENST00000371741.4	-	2	2372_2373	c.2206_2207insC	c.(2206-2208)gtcfs	p.V736fs		NM_004975.2	NP_004966.1	Q14721	KCNB1_HUMAN	potassium voltage-gated channel, Shab-related subfamily, member 1	736					energy reserve metabolic process|regulation of insulin secretion	voltage-gated potassium channel complex	protein binding|voltage-gated potassium channel activity			central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(8)|liver(1)|lung(22)|pancreas(2)|prostate(7)|skin(4)|stomach(1)|urinary_tract(1)	53			BRCA - Breast invasive adenocarcinoma(12;0.000405)|COAD - Colon adenocarcinoma(4;0.14)|Colorectal(8;0.166)			CTCAGGAGACCGGGGGGGTGTC	0.559													12	259	---	---	---	---					
SALL4	57167	broad.mit.edu	37	20	50400982	50400983	+	Frame_Shift_Ins	INS	-	-	C			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr20:50400982_50400983insC	ENST00000217086.4	-	4	3094_3095	c.2983_2984insG	c.(2983-2985)tccfs	p.S995fs	SALL4_ENST00000395997.3_Frame_Shift_Ins_p.S558fs|SALL4_ENST00000371539.3_Frame_Shift_Ins_p.S218fs	NM_020436.3	NP_065169.1	Q9UJQ4	SALL4_HUMAN	spalt-like transcription factor 4	995					transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(27)|ovary(5)|prostate(2)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	63						GAGGGTAGGAACCCCCCCACTC	0.559													8	119	---	---	---	---					
PMEPA1	56937	broad.mit.edu	37	20	56227348	56227349	+	Frame_Shift_Ins	INS	-	-	G			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr20:56227348_56227349insG	ENST00000341744.3	-	4	943_944	c.624_625insC	c.(622-627)ccgcagfs	p.Q209fs	PMEPA1_ENST00000347215.4_Frame_Shift_Ins_p.Q174fs|PMEPA1_ENST00000265626.4_Frame_Shift_Ins_p.Q159fs|PMEPA1_ENST00000395816.3_Frame_Shift_Ins_p.Q159fs|PMEPA1_ENST00000395814.1_Frame_Shift_Ins_p.Q159fs	NM_020182.4	NP_064567.2	Q969W9	PMEPA_HUMAN	prostate transmembrane protein, androgen induced 1	209					androgen receptor signaling pathway	integral to membrane|plasma membrane	WW domain binding			breast(3)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(4)|pancreas(1)|prostate(1)	16						GAGTTACTGCTGGGGGGGCAGG	0.683													13	150	---	---	---	---					
OSBPL2	9885	broad.mit.edu	37	20	60854257	60854258	+	Frame_Shift_Ins	INS	-	-	C	rs79735057		TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr20:60854257_60854258insC	ENST00000313733.3	+	7	738_739	c.536_537insC	c.(535-537)cccfs	p.P179fs	OSBPL2_ENST00000439951.2_Frame_Shift_Ins_p.P87fs|OSBPL2_ENST00000358053.2_Frame_Shift_Ins_p.P167fs	NM_144498.1	NP_653081.1	Q9H1P3	OSBL2_HUMAN	oxysterol binding protein-like 2	179					lipid transport		lipid binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|large_intestine(2)|lung(8)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	17	Breast(26;7.76e-09)		BRCA - Breast invasive adenocarcinoma(19;1.33e-06)			GTCAGTCACCACCCCCCCATCA	0.465													11	190	---	---	---	---					
HUNK	30811	broad.mit.edu	37	21	33296950	33296951	+	Frame_Shift_Ins	INS	-	-	G	rs55847614	byFrequency	TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr21:33296950_33296951insG	ENST00000270112.2	+	2	792_793	c.432_433insG	c.(430-435)ccggggfs	p.PG144fs		NM_014586.1	NP_055401.1	P57058	HUNK_HUMAN	hormonally up-regulated Neu-associated kinase	144	Protein kinase.				multicellular organismal development|signal transduction		ATP binding|protein serine/threonine kinase activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(15)|ovary(1)|skin(2)|stomach(1)	30						AGCTGTGCCCTGGGGGCAACCT	0.535													7	754	---	---	---	---					
DSCAM	1826	broad.mit.edu	37	21	41514614	41514615	+	Frame_Shift_Ins	INS	-	-	G			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr21:41514614_41514615insG	ENST00000400454.1	-	18	3753_3754	c.3276_3277insC	c.(3274-3279)ccaaaafs	p.PK1092fs		NM_001389.3	NP_001380.2	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule	1092	Fibronectin type-III 3.				cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding	p.E1093K(1)		NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(22)|lung(47)|ovary(7)|pancreas(2)|prostate(3)|skin(14)|upper_aerodigestive_tract(6)|urinary_tract(4)	142		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				TGGACATTTTCGGGGGGGTAAC	0.406													15	673	---	---	---	---					
PDE9A	5152	broad.mit.edu	37	21	44171249	44171250	+	Frame_Shift_Ins	INS	-	-	T			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr21:44171249_44171250insT	ENST00000291539.6	+	9	737_738	c.677_678insT	c.(676-678)attfs	p.I226fs	PDE9A_ENST00000349112.3_Frame_Shift_Ins_p.I98fs|PDE9A_ENST00000398227.3_Frame_Shift_Ins_p.I66fs|PDE9A_ENST00000335440.6_Frame_Shift_Ins_p.I124fs|PDE9A_ENST00000380328.2_Frame_Shift_Ins_p.I173fs|PDE9A_ENST00000398234.3_Frame_Shift_Ins_p.I125fs|PDE9A_ENST00000328862.6_Frame_Shift_Ins_p.I200fs|PDE9A_ENST00000398232.3_Frame_Shift_Ins_p.I159fs|PDE9A_ENST00000470987.1_3'UTR|PDE9A_ENST00000398224.3_Frame_Shift_Ins_p.I99fs|PDE9A_ENST00000398225.3_Frame_Shift_Ins_p.I185fs|PDE9A_ENST00000398236.3_Frame_Shift_Ins_p.I140fs|PDE9A_ENST00000398229.3_Frame_Shift_Ins_p.I92fs|PDE9A_ENST00000539837.1_Frame_Shift_Ins_p.I98fs|PDE9A_ENST00000335512.4_Frame_Shift_Ins_p.I166fs	NM_002606.2	NP_002597.1	O76083	PDE9A_HUMAN	phosphodiesterase 9A	226					platelet activation|signal transduction	cytosol|endoplasmic reticulum|Golgi apparatus|perinuclear region of cytoplasm|ruffle membrane	3',5'-cyclic-GMP phosphodiesterase activity|metal ion binding|protein binding			breast(1)|endometrium(4)|large_intestine(6)|lung(8)|ovary(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	27						TGTAAGTACAGTTTTTTGGATA	0.520													8	873	---	---	---	---					
MCM3AP	8888	broad.mit.edu	37	21	47666704	47666705	+	Frame_Shift_Ins	INS	-	-	G			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr21:47666704_47666705insG	ENST00000397708.1	-	22	4640_4641	c.4386_4387insC	c.(4384-4389)ccaaatfs	p.N1463fs	MCM3AP_ENST00000467026.1_5'UTR|MCM3AP_ENST00000291688.1_Frame_Shift_Ins_p.N1463fs|MCM3AP-AS1_ENST00000590829.1_RNA|MCM3AP-AS1_ENST00000455567.1_RNA|MCM3AP-AS1_ENST00000414659.1_RNA			O60318	MCM3A_HUMAN	minichromosome maintenance complex component 3 associated protein	1463					DNA replication|protein import into nucleus	cytosol|nucleus	DNA binding|nucleotide binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(10)|kidney(5)|large_intestine(17)|lung(24)|ovary(4)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	72	Breast(49;0.112)					CTCTTCATTTTGGGGGGAAGCA	0.609													8	613	---	---	---	---					
CECR2	27443	broad.mit.edu	37	22	18022285	18022286	+	Frame_Shift_Ins	INS	-	-	C			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr22:18022285_18022286insC	ENST00000262608.8	+	15	2390_2391	c.2390_2391insC	c.(2389-2391)gccfs	p.A797fs	CECR2_ENST00000400585.2_Frame_Shift_Ins_p.A655fs|CECR2_ENST00000400573.4_Frame_Shift_Ins_p.A796fs	NM_031413.3	NP_113601.2	Q9BXF3	CECR2_HUMAN	cat eye syndrome chromosome region, candidate 2	838					chromatin modification|cytokinesis|cytoskeleton organization|DNA fragmentation involved in apoptotic nuclear change|vesicle-mediated transport		protein binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(22)|ovary(1)|pancreas(1)|prostate(2)|skin(5)|stomach(1)|urinary_tract(1)	59		all_epithelial(15;0.139)		Lung(27;0.146)		AGACCACCTGTCCCCCCCAACC	0.609													12	247	---	---	---	---					
PI4KA	5297	broad.mit.edu	37	22	21119387	21119388	+	Splice_Site	INS	-	-	G			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr22:21119387_21119388insG	ENST00000255882.6	-	21	2660_2661		c.e21+1		PI4KA_ENST00000466162.1_Splice_Site|PI4KA_ENST00000572273.1_Splice_Site	NM_058004.3	NP_477352.3	P42356	PI4KA_HUMAN	phosphatidylinositol 4-kinase, catalytic, alpha						phosphatidylinositol biosynthetic process|phosphatidylinositol-mediated signaling|synaptic transmission	Golgi-associated vesicle	1-phosphatidylinositol 4-kinase activity|ATP binding|protein binding			breast(3)|endometrium(8)|kidney(9)|large_intestine(19)|lung(29)|ovary(1)|pancreas(1)|prostate(3)|salivary_gland(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	79	all_cancers(11;7.59e-25)|all_epithelial(7;1.34e-22)|Melanoma(16;0.000465)|Ovarian(15;0.00167)|Colorectal(54;0.0332)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.000536)|Lung(15;0.0108)|Epithelial(17;0.196)			TGAATCCTTACGGGGGTGACCG	0.490													8	564	---	---	---	---					
SERPIND1	3053	broad.mit.edu	37	22	21138419	21138420	+	Frame_Shift_Ins	INS	-	-	G			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr22:21138419_21138420insG	ENST00000215727.5	+	3	1332_1333	c.1049_1050insG	c.(1048-1050)gggfs	p.G350fs	PI4KA_ENST00000466162.1_Intron|SERPIND1_ENST00000406799.1_Frame_Shift_Ins_p.G350fs|PI4KA_ENST00000572273.1_Intron|PI4KA_ENST00000255882.6_Intron	NM_000185.3	NP_000176.2	P05546	HEP2_HUMAN	serpin peptidase inhibitor, clade D (heparin cofactor), member 1	350					blood coagulation|chemotaxis|regulation of proteolysis	extracellular region	heparin binding|serine-type endopeptidase inhibitor activity			breast(2)|endometrium(3)|kidney(1)|large_intestine(2)|lung(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	13	all_cancers(11;6.16e-25)|all_epithelial(7;1.02e-22)|Melanoma(16;0.000465)|Ovarian(15;0.00167)|Colorectal(54;0.0332)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.000536)|Lung(15;0.0108)|Epithelial(17;0.196)		Ardeparin(DB00407)	CTGGAATACGTGGGGGGCATCA	0.540											OREG0026325	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	7	422	---	---	---	---					
BMS1P20	96610	broad.mit.edu	37	22	22661173	22661174	+	RNA	INS	-	-	C	rs7410785		TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr22:22661173_22661174insC	ENST00000426066.1	+	0	265_266					NR_027293.1																						ATACAGGTTTTCCCCCCCCACC	0.406													7	127	---	---	---	---					
ZNF70	7621	broad.mit.edu	37	22	24087085	24087086	+	Frame_Shift_Ins	INS	-	-	G			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr22:24087085_24087086insG	ENST00000341976.3	-	2	702_703	c.242_243insC	c.(241-243)cggfs	p.R81fs		NM_021916.2	NP_068735.1	Q9UC06	ZNF70_HUMAN	zinc finger protein 70	81						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(7)|ovary(3)|prostate(1)|urinary_tract(1)	21						GTCTGGTTCCTGGGGGGATACT	0.495													8	1008	---	---	---	---					
DDX17	10521	broad.mit.edu	37	22	38895454	38895455	+	Frame_Shift_Ins	INS	-	-	C			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr22:38895454_38895455insC	ENST00000396821.3	-	3	587_588	c.488_489insG	c.(487-489)ggafs	p.G163fs	DDX17_ENST00000432525.1_5'UTR|DDX17_ENST00000381633.3_Frame_Shift_Ins_p.G84fs	NM_001098504.1|NM_006386.4	NP_001091974.1|NP_006377.2	Q92841	DDX17_HUMAN	DEAD (Asp-Glu-Ala-Asp) box helicase 17	84	Helicase ATP-binding.				RNA processing	nucleus	ATP binding|ATP-dependent helicase activity|RNA binding|RNA helicase activity|RNA-dependent ATPase activity	p.G163fs*20(1)		breast(1)|endometrium(1)|kidney(3)|large_intestine(9)|lung(6)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	25	Melanoma(58;0.0286)					GACAAACATCTCCCCCCCTCAC	0.381													13	286	---	---	---	---					
TBC1D22A	25771	broad.mit.edu	37	22	47188443	47188444	+	Frame_Shift_Ins	INS	-	-	C			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chr22:47188443_47188444insC	ENST00000337137.4	+	2	255_256	c.89_90insC	c.(88-90)cccfs	p.P30fs	TBC1D22A_ENST00000472791.1_3'UTR|TBC1D22A_ENST00000407381.3_Frame_Shift_Ins_p.P30fs|TBC1D22A_ENST00000406733.1_5'UTR|TBC1D22A_ENST00000380995.1_5'UTR|TBC1D22A_ENST00000355704.3_Intron	NM_014346.2	NP_055161.1	Q8WUA7	TB22A_HUMAN	TBC1 domain family, member 22A	30						intracellular	protein homodimerization activity|Rab GTPase activator activity			breast(1)|endometrium(3)|large_intestine(10)|lung(5)|ovary(2)|prostate(1)	22		all_cancers(38;4.44e-05)|all_epithelial(38;0.000507)|Breast(42;0.0488)|all_lung(38;0.0682)|Ovarian(80;0.0731)|all_neural(38;0.0966)|Glioma(61;0.222)|Lung SC(80;0.236)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0347)|BRCA - Breast invasive adenocarcinoma(115;0.231)		GGTGCCCAGCACCCCCCCTTTG	0.569													13	501	---	---	---	---					
TFE3	7030	broad.mit.edu	37	X	48887951	48887952	+	Frame_Shift_Ins	INS	-	-	C			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chrX:48887951_48887952insC	ENST00000315869.7	-	10	1704_1705	c.1445_1446insG	c.(1444-1446)gccfs	p.A482fs	TFE3_ENST00000493583.1_5'UTR	NM_006521.4	NP_006512.2	P19532	TFE3_HUMAN	transcription factor binding to IGHM enhancer 3	482					humoral immune response|positive regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding		NONO/TFE3(2)|PRCC/TFE3(25)|SFPQ/TFE3(6)|CLTC/TFE3(2)|ASPSCR1/TFE3(167)	central_nervous_system(1)	1						TCTGGGCAGGTCCCCCCCCTAC	0.649			T	"""SFPQ, ASPSCR1, PRCC, NONO, CLTC"""	"""papillary renal, alveolar soft part sarcoma, renal"""								39	237	---	---	---	---					
DGKK	139189	broad.mit.edu	37	X	50165268	50165269	+	RNA	INS	-	-	T			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chrX:50165268_50165269insT	ENST00000376025.2	-	0	897							Q5KSL6	DGKK_HUMAN	diacylglycerol kinase, kappa						activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|diacylglycerol metabolic process|intracellular signal transduction|platelet activation|response to oxidative stress	cytoplasm|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			central_nervous_system(1)|endometrium(12)|kidney(4)|large_intestine(5)|lung(18)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	45	Ovarian(276;0.236)					AAGACCATCACTTTTTTTCTTC	0.381													2	4	---	---	---	---					
SHROOM4	57477	broad.mit.edu	37	X	50350711	50350713	+	In_Frame_Del	DEL	TCC	TCC	-	rs6614551		TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chrX:50350711_50350713delTCC	ENST00000376020.2	-	6	3454_3456	c.3429_3431delGGA	c.(3427-3432)gaa>ga	p.EE1149del	SHROOM4_ENST00000289292.7_In_Frame_Del_p.EE1149del|SHROOM4_ENST00000460112.3_In_Frame_Del_p.EE1033del	NM_020717.3	NP_065768.2	Q9ULL8	SHRM4_HUMAN	shroom family member 4	1149	Glu-rich.				actin filament organization|brain development|cell morphogenesis|cognition	apical plasma membrane|basal plasma membrane|internal side of plasma membrane|nucleus	actin filament binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(5)|large_intestine(6)|liver(1)|lung(20)|ovary(1)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)	52	Ovarian(276;0.236)					ctcttcctcttcctcttcttctt	0.547													8	26	---	---	---	---					
IL2RG	3561	broad.mit.edu	37	X	70327613	70327614	+	Frame_Shift_Ins	INS	-	-	G			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chrX:70327613_70327614insG	ENST00000374202.2	-	8	1173_1174	c.1082_1083insC	c.(1081-1083)ctgfs	p.L361fs	IL2RG_ENST00000456850.2_Frame_Shift_Ins_p.L171fs|IL2RG_ENST00000374188.3_Frame_Shift_Ins_p.L90fs	NM_000206.2	NP_000197.1	P31785	IL2RG_HUMAN	interleukin 2 receptor, gamma	361					immune response|interleukin-4-mediated signaling pathway|interspecies interaction between organisms	external side of plasma membrane|integral to plasma membrane	cytokine receptor activity|interleukin-2 binding			breast(1)|endometrium(3)|large_intestine(1)|lung(7)|pancreas(1)|prostate(1)|urinary_tract(1)	15	Renal(35;0.156)				Aldesleukin(DB00041)|Denileukin diftitox(DB00004)	GGGTGTAACATGGGGGGGCCCA	0.584									Severe Combined Immunodeficiency, X-linked				7	110	---	---	---	---					
FRMPD3	84443	broad.mit.edu	37	X	106844202	106844203	+	Frame_Shift_Ins	INS	-	-	C			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chrX:106844202_106844203insC	ENST00000276185.4	+	16	3032_3033	c.3032_3033insC	c.(3031-3033)accfs	p.T1011fs				Q5JV73	FRPD3_HUMAN	FERM and PDZ domain containing 3	1011						cytoskeleton				breast(3)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(16)|ovary(2)|urinary_tract(1)	28						GCTTTGGGGAACCCCCCCAGCA	0.559													7	43	---	---	---	---					
FRMPD3	84443	broad.mit.edu	37	X	106845402	106845403	+	Frame_Shift_Ins	INS	-	-	G			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chrX:106845402_106845403insG	ENST00000276185.4	+	16	4232_4233	c.4232_4233insG	c.(4231-4233)tggfs	p.W1411fs				Q5JV73	FRPD3_HUMAN	FERM and PDZ domain containing 3	1411						cytoskeleton				breast(3)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(16)|ovary(2)|urinary_tract(1)	28						ACGTGTGCCTCGGGGGGCGAGT	0.609													7	261	---	---	---	---					
ZCCHC12	170261	broad.mit.edu	37	X	117960135	117960136	+	Frame_Shift_Ins	INS	-	-	C			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chrX:117960135_117960136insC	ENST00000310164.2	+	4	1435_1436	c.928_929insC	c.(928-930)cccfs	p.P310fs		NM_173798.2	NP_776159.1	Q6PEW1	ZCH12_HUMAN	zinc finger, CCHC domain containing 12	310					regulation of transcription, DNA-dependent|transcription, DNA-dependent		nucleic acid binding|zinc ion binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(13)|ovary(1)|prostate(2)	22						GGTCATTGATTCCCCCCACAAT	0.564													8	546	---	---	---	---					
F8	2157	broad.mit.edu	37	X	154157685	154157686	+	Frame_Shift_Ins	INS	-	-	T			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01D-0966-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	c1c63fb7-47c4-4d5c-ad01-6a51f605475e	g.chrX:154157685_154157686insT	ENST00000360256.4	-	14	4579_4580	c.4379_4380insA	c.(4378-4380)aaafs	p.K1460fs		NM_000132.3	NP_000123.1	P00451	FA8_HUMAN	coagulation factor VIII, procoagulant component	1460	B.		N -> K (in HEMA).		acute-phase response|blood coagulation, intrinsic pathway|cell adhesion|platelet activation|platelet degranulation	extracellular space|plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity|protein binding	p.N1460fs*5(2)|p.N1460fs*2(2)		NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(27)|liver(1)|lung(47)|ovary(5)|pancreas(3)|prostate(1)|skin(5)|upper_aerodigestive_tract(5)|urinary_tract(2)	120	all_cancers(53;7.19e-17)|all_epithelial(53;9.83e-11)|all_lung(58;6.63e-07)|Lung NSC(58;2.08e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)				Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Drotrecogin alfa(DB00055)	AAGAAAGGTTATTTTTTTTGGC	0.416													8	466	---	---	---	---					
RPE65	6121	broad.mit.edu	37	1	68897205	68897206	+	Frame_Shift_Ins	INS	-	-	A			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	14591343-b381-43d0-aea0-0e02221c09c6	g.chr1:68897205_68897206insA	ENST00000262340.5	-	11	1244_1245	c.1191_1192insT	c.(1189-1194)agacgafs	p.RR397fs		NM_000329.2	NP_000320.1	Q16518	RPE65_HUMAN	retinal pigment epithelium-specific protein 65kDa	397					visual perception	cytoplasm|plasma membrane	all-trans-retinyl-palmitate hydrolase activity|metal ion binding|retinol isomerase activity			central_nervous_system(1)|kidney(3)|large_intestine(12)|lung(15)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	35						ATAGTCTCGTCACTGCACAGAA	0.470													44	119	---	---	---	---					
NUP133	55746	broad.mit.edu	37	1	229600610	229600620	+	Frame_Shift_Del	DEL	GGACCACTTGT	GGACCACTTGT	-			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	14591343-b381-43d0-aea0-0e02221c09c6	g.chr1:229600610_229600620delGGACCACTTGT	ENST00000261396.3	-	18	2393_2403	c.2302_2312delACAAGTGGTCC	c.(2302-2313)tfs	p.TSGP768fs	NUP133_ENST00000537506.1_Frame_Shift_Del_p.TSGP752fs|NUP133_ENST00000366679.1_Frame_Shift_Del_p.TSGP768fs	NM_018230.2	NP_060700.2	Q8WUM0	NU133_HUMAN	nucleoporin 133kDa	768					carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA export from nucleus|nuclear pore organization|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytosol|Nup107-160 complex	nucleocytoplasmic transporter activity|protein binding			NS(1)|breast(7)|endometrium(1)|kidney(6)|large_intestine(9)|lung(20)|ovary(1)|pancreas(1)|prostate(3)|skin(3)|stomach(4)	56	Breast(184;0.104)|Ovarian(103;0.249)	Prostate(94;0.167)				GATGCCACCAGGACCACTTGTTGCTGTGAAA	0.436													13	191	---	---	---	---					
PBRM1	55193	broad.mit.edu	37	3	52702569	52702569	+	Frame_Shift_Del	DEL	T	T	-			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	14591343-b381-43d0-aea0-0e02221c09c6	g.chr3:52702569delT	ENST00000356770.4	-	3	331	c.329delA	c.(328-330)atfs	p.N110fs	PBRM1_ENST00000296302.7_Frame_Shift_Del_p.N110fs|PBRM1_ENST00000409767.1_Frame_Shift_Del_p.N110fs|PBRM1_ENST00000410007.1_Frame_Shift_Del_p.N110fs|PBRM1_ENST00000409114.3_Frame_Shift_Del_p.N110fs|PBRM1_ENST00000409057.1_Frame_Shift_Del_p.N110fs|PBRM1_ENST00000337303.4_Frame_Shift_Del_p.N110fs|PBRM1_ENST00000394830.3_Frame_Shift_Del_p.N110fs			Q86U86	PB1_HUMAN	polybromo 1	110	Bromo 1.				chromatin remodeling|mitosis|negative regulation of cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear chromosome	chromatin binding|DNA binding|protein binding	p.N110fs*3(3)		breast(5)|endometrium(5)|kidney(301)|liver(1)|lung(22)|pancreas(1)	335				BRCA - Breast invasive adenocarcinoma(193;1.8e-05)|Kidney(197;0.00105)|KIRC - Kidney renal clear cell carcinoma(197;0.00122)|OV - Ovarian serous cystadenocarcinoma(275;0.0613)		AGTCAGCAAATTAACATCATC	0.328			"""Mis, N, F, S, D, O"""		"""clear cell renal carcinoma, breast"""								21	38	---	---	---	---					
COPB2	9276	broad.mit.edu	37	3	139090606	139090606	+	Frame_Shift_Del	DEL	A	A	-			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	14591343-b381-43d0-aea0-0e02221c09c6	g.chr3:139090606delA	ENST00000333188.5	-	10	1345	c.1164delT	c.(1162-1164)ttfs	p.F388fs	COPB2_ENST00000507777.1_Frame_Shift_Del_p.F359fs	NM_004766.2	NP_004757.1	P35606	COPB2_HUMAN	coatomer protein complex, subunit beta 2 (beta prime)	388					COPI coating of Golgi vesicle|intra-Golgi vesicle-mediated transport|intracellular protein transport|retrograde vesicle-mediated transport, Golgi to ER	COPI vesicle coat|cytosol	protein binding|structural molecule activity			breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(4)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	24						GAGCAGATCCAAAGCTCTTGT	0.468													116	263	---	---	---	---					
ZKSCAN3	80317	broad.mit.edu	37	6	28334004	28334004	+	Frame_Shift_Del	DEL	T	T	-			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	14591343-b381-43d0-aea0-0e02221c09c6	g.chr6:28334004delT	ENST00000377255.3	+	7	1856	c.1559delT	c.(1558-1560)atfs	p.I520fs	ZKSCAN3_ENST00000252211.2_Frame_Shift_Del_p.I520fs|ZKSCAN3_ENST00000341464.5_Frame_Shift_Del_p.I372fs	NM_001242894.1	NP_001229823.1	Q9BRR0	ZKSC3_HUMAN	zinc finger with KRAB and SCAN domains 3	520					positive regulation of transcription, DNA-dependent|viral reproduction	nucleus	chromatin binding|DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			kidney(4)|large_intestine(3)|lung(8)|pancreas(1)|skin(2)|stomach(2)|urinary_tract(1)	21						TTCACCCGAATTTCATACCTT	0.433													126	202	---	---	---	---					
BAG6	7917	broad.mit.edu	37	6	31608570	31608571	+	Splice_Site	INS	-	-	G			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	14591343-b381-43d0-aea0-0e02221c09c6	g.chr6:31608570_31608571insG	ENST00000404765.2	-	21	3221_3222	c.2934_splice	c.e21+1	p.A978_splice	BAG6_ENST00000211379.5_Splice_Site_p.A942_splice|BAG6_ENST00000375964.6_Splice_Site_p.A948_splice|BAG6_ENST00000362049.6_Splice_Site_p.A942_splice|BAG6_ENST00000439687.2_Splice_Site_p.A816_splice|BAG6_ENST00000375976.4_Splice_Site_p.A942_splice			P46379	BAG6_HUMAN	BCL2-associated athanogene 6	948					apoptosis in response to endoplasmic reticulum stress|brain development|cell differentiation|chromatin modification|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|embryo development|internal peptidyl-lysine acetylation|kidney development|lung development|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|protein stabilization|spermatogenesis|synaptonemal complex assembly|tail-anchored membrane protein insertion into ER membrane|transport|ubiquitin-dependent protein catabolic process	BAT3 complex|nucleus	polyubiquitin binding|proteasome binding|ribosome binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(18)|ovary(2)|pancreas(2)|skin(3)|urinary_tract(2)	36						GTCCCTTACCTGGGGGGGATCA	0.535													7	296	---	---	---	---					
AIM1	202	broad.mit.edu	37	6	107011654	107011655	+	Frame_Shift_Del	DEL	TG	TG	-			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	14591343-b381-43d0-aea0-0e02221c09c6	g.chr6:107011654_107011655delTG	ENST00000369066.3	+	19	5417_5418	c.4930_4931delTG	c.(4930-4932)cfs	p.C1644fs	AIM1_ENST00000535438.1_Frame_Shift_Del_p.C463fs	NM_001624.2	NP_001615.1	Q9Y4K1	AIM1_HUMAN	absent in melanoma 1	1644	Ricin B-type lectin.						sugar binding			breast(8)|central_nervous_system(1)|cervix(2)|endometrium(6)|kidney(7)|large_intestine(13)|lung(20)|ovary(5)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	69	Breast(9;0.0138)|all_epithelial(6;0.169)	all_cancers(87;4.67e-25)|all_epithelial(87;5.46e-21)|Acute lymphoblastic leukemia(125;2.15e-07)|all_hematologic(75;5.28e-06)|Colorectal(196;3.46e-05)|all_lung(197;5.94e-05)|Lung NSC(302;7.26e-05)|Ovarian(999;0.00473)	Epithelial(6;0.00114)|all cancers(7;0.00726)|BRCA - Breast invasive adenocarcinoma(8;0.0114)|OV - Ovarian serous cystadenocarcinoma(5;0.0305)	all cancers(137;1.73e-50)|Epithelial(106;2.42e-48)|OV - Ovarian serous cystadenocarcinoma(136;1.51e-27)|BRCA - Breast invasive adenocarcinoma(108;0.00104)|GBM - Glioblastoma multiforme(226;0.00858)		AGAAGACTGCTGCCTGACGATT	0.490													46	150	---	---	---	---					
ZCWPW1	55063	broad.mit.edu	37	7	100004397	100004398	+	Frame_Shift_Ins	INS	-	-	A			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	14591343-b381-43d0-aea0-0e02221c09c6	g.chr7:100004397_100004398insA	ENST00000398027.2	-	12	1336_1337	c.1089_1090insT	c.(1087-1092)ttgagafs	p.LR363fs	ZCWPW1_ENST00000490721.1_Frame_Shift_Ins_p.LR243fs|ZCWPW1_ENST00000360951.4_Frame_Shift_Ins_p.LR364fs|ZCWPW1_ENST00000324725.6_Frame_Shift_Ins_p.LR243fs	NM_017984.4	NP_060454.3	Q9H0M4	ZCPW1_HUMAN	zinc finger, CW type with PWWP domain 1	363	PWWP.						zinc ion binding			breast(1)|kidney(1)|large_intestine(5)|lung(6)|ovary(1)|prostate(1)|skin(1)	16	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					ACTGTTTCTCCAAAAAACGTCA	0.480													8	442	---	---	---	---					
PLXNA4	91584	broad.mit.edu	37	7	131831316	131831317	+	Frame_Shift_Ins	INS	-	-	C			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	14591343-b381-43d0-aea0-0e02221c09c6	g.chr7:131831316_131831317insC	ENST00000359827.3	-	28	5969_5970	c.5007_5008insG	c.(5005-5010)gggcaafs	p.Q1670fs	PLXNA4_ENST00000321063.4_Frame_Shift_Ins_p.Q1670fs			Q9HCM2	PLXA4_HUMAN	plexin A4	1670						integral to membrane|intracellular|plasma membrane				NS(1)|breast(1)|endometrium(3)|kidney(4)|large_intestine(14)|lung(17)|ovary(1)|prostate(2)|skin(1)|stomach(1)	45						ACCATCTTGCTCCCCCGGTCCC	0.569													8	1455	---	---	---	---					
FAM66D	100132923	broad.mit.edu	37	8	11994626	11994627	+	RNA	DEL	GT	GT	-	rs138516564	by1000genomes	TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	14591343-b381-43d0-aea0-0e02221c09c6	g.chr8:11994626_11994627delGT	ENST00000434078.2	+	0	608					NR_027425.1																						gtatttgtgcgtgtgtgtgtgt	0.510													10	93	---	---	---	---					
BACE1	23621	broad.mit.edu	37	11	117167622	117167623	+	Frame_Shift_Ins	INS	-	-	G			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	14591343-b381-43d0-aea0-0e02221c09c6	g.chr11:117167622_117167623insG	ENST00000313005.6	-	2	776_777	c.316_317insC	c.(316-318)cccfs	p.P106fs	BACE1_ENST00000445823.2_Frame_Shift_Ins_p.P106fs|BACE1_ENST00000528053.1_Frame_Shift_Ins_p.P106fs|BACE1_ENST00000428381.2_Frame_Shift_Ins_p.P106fs|BACE1_ENST00000514464.1_5'UTR|BACE1_ENST00000513780.1_Frame_Shift_Ins_p.P106fs	NM_012104.4|NM_138971.3|NM_138972.3|NM_138973.3	NP_036236.1|NP_620427.1|NP_620428.1|NP_620429.1	P56817	BACE1_HUMAN	beta-site APP-cleaving enzyme 1	106					beta-amyloid metabolic process|membrane protein ectodomain proteolysis	cell surface|cytoplasmic vesicle membrane|endoplasmic reticulum|endosome|integral to plasma membrane|trans-Golgi network	aspartic-type endopeptidase activity|beta-aspartyl-peptidase activity|protein binding			breast(2)|endometrium(4)|kidney(1)|large_intestine(2)|lung(7)|ovary(2)|prostate(1)	19	all_hematologic(175;0.0487)	Breast(348;0.00908)|Medulloblastoma(222;0.0425)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;1.69e-05)|Epithelial(105;0.000563)|all cancers(92;0.0032)		CAGGAAGGGGTGGGGGGCAGCA	0.569													7	305	---	---	---	---					
PRB2	653247	broad.mit.edu	37	12	11546135	11546137	+	In_Frame_Del	DEL	TGC	TGC	-			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	14591343-b381-43d0-aea0-0e02221c09c6	g.chr12:11546135_11546137delTGC	ENST00000389362.4	-	3	910_912	c.875_877delGCA	c.(874-879)aag>a	p.SK292del	PRB1_ENST00000546254.1_Intron	NM_006248.3	NP_006239.3			proline-rich protein BstNI subfamily 2											NS(1)|breast(1)|endometrium(2)|kidney(3)|large_intestine(3)|lung(14)|pancreas(1)|prostate(5)|skin(4)|stomach(2)|urinary_tract(1)	37		all_cancers(2;0.00558)|Acute lymphoblastic leukemia(2;3.94e-11)|all_hematologic(2;3.6e-09)	OV - Ovarian serous cystadenocarcinoma(49;0.185)			CTTCGGGACTTGCTGCCTCCTTG	0.606													7	1267	---	---	---	---					
ZNF646	9726	broad.mit.edu	37	16	31089750	31089751	+	Frame_Shift_Ins	INS	-	-	T			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	14591343-b381-43d0-aea0-0e02221c09c6	g.chr16:31089750_31089751insT	ENST00000394979.2	+	1	2528_2529	c.2105_2106insT	c.(2104-2106)agafs	p.R702fs	ZNF646_ENST00000300850.5_Frame_Shift_Ins_p.R702fs			O15015	ZN646_HUMAN	zinc finger protein 646	702					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			NS(1)|breast(4)|cervix(2)|endometrium(8)|kidney(4)|large_intestine(1)|lung(21)|ovary(1)|prostate(4)|skin(3)	49						CTAGAAGACAATGAAGGCCTGG	0.619													8	36	---	---	---	---					
RP11-252A24.2	0	broad.mit.edu	37	16	74372597	74372597	+	RNA	DEL	A	A	-			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	14591343-b381-43d0-aea0-0e02221c09c6	g.chr16:74372597delA	ENST00000429810.2	-	0	1599																											TTCCCAGGACAAAAAAAAAAA	0.403													8	39	---	---	---	---					
NPIPB15	440348	broad.mit.edu	37	16	74423894	74423895	+	Splice_Site	INS	-	-	C			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	14591343-b381-43d0-aea0-0e02221c09c6	g.chr16:74423894_74423895insC	ENST00000429990.1	+	6	704_705	c.606_splice	c.e6-1	p.T203_splice						nuclear pore complex interacting protein family, member B15																		CTTTTTCAGATCCCCCCTTCTG	0.455													9	951	---	---	---	---					
TLDC1	57707	broad.mit.edu	37	16	84514302	84514303	+	Frame_Shift_Ins	INS	-	-	C			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	14591343-b381-43d0-aea0-0e02221c09c6	g.chr16:84514302_84514303insC	ENST00000343629.6	-	7	1271_1272	c.1089_1090insG	c.(1087-1092)ggagcafs	p.A364fs	TLDC1_ENST00000535580.1_Frame_Shift_Ins_p.A337fs	NM_020947.3	NP_065998.3			TBC/LysM-associated domain containing 1																		TAATTGTGCTGCCCCCCCATAC	0.550													10	122	---	---	---	---					
RPA1	6117	broad.mit.edu	37	17	1782982	1782983	+	Frame_Shift_Ins	INS	-	-	G			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	14591343-b381-43d0-aea0-0e02221c09c6	g.chr17:1782982_1782983insG	ENST00000254719.5	+	11	1191_1192	c.1081_1082insG	c.(1081-1083)gggfs	p.G361fs		NM_002945.3	NP_002936.1	P27694	RFA1_HUMAN	replication protein A1, 70kDa	361					cell cycle checkpoint|DNA recombinase assembly|DNA strand elongation involved in DNA replication|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|nucleotide-excision repair, DNA damage removal|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	actin cytoskeleton|cytoplasm|DNA replication factor A complex|PML body	metal ion binding|protein binding|single-stranded DNA binding			breast(1)|endometrium(3)|large_intestine(2)|lung(2)|ovary(2)	10						TGCTACACTGTGGGGGGAAGAT	0.530								Nucleotide excision repair (NER)					7	895	---	---	---	---					
CHERP	10523	broad.mit.edu	37	19	16633993	16633994	+	Frame_Shift_Ins	INS	-	-	G			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	14591343-b381-43d0-aea0-0e02221c09c6	g.chr19:16633993_16633994insG	ENST00000546361.2	-	11	2000_2001	c.1849_1850insC	c.(1849-1851)tggfs	p.W617fs	CTD-3222D19.2_ENST00000409035.1_Intron|CHERP_ENST00000544299.1_5'UTR|CHERP_ENST00000198939.6_Frame_Shift_Ins_p.W628fs	NM_006387.5	NP_006378.3	Q8IWX8	CHERP_HUMAN	calcium homeostasis endoplasmic reticulum protein	617	Pro-rich.				cellular calcium ion homeostasis|negative regulation of cell proliferation|nervous system development|RNA processing	endoplasmic reticulum|perinuclear region of cytoplasm	RNA binding			endometrium(3)|kidney(2)|large_intestine(4)|lung(9)|ovary(2)|stomach(1)|urinary_tract(3)	24						GTTGAAGCCATGGGGGGGAGGG	0.673													7	53	---	---	---	---					
ZNF600	162966	broad.mit.edu	37	19	53270877	53270877	+	Frame_Shift_Del	DEL	A	A	-			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	14591343-b381-43d0-aea0-0e02221c09c6	g.chr19:53270877delA	ENST00000338230.3	-	3	399	c.132delT	c.(130-132)atfs	p.I44fs		NM_198457.2	NP_940859.2	Q6ZNG1	ZN600_HUMAN	zinc finger protein 600	44					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(2)|kidney(4)|large_intestine(9)|liver(1)|lung(10)|prostate(1)|upper_aerodigestive_tract(1)	30				OV - Ovarian serous cystadenocarcinoma(262;0.0241)|GBM - Glioblastoma multiforme(134;0.0404)		ACTGAAACTCAATATCATGAA	0.378													249	564	---	---	---	---					
KIR2DL4	3805	broad.mit.edu	37	19	55324675	55324675	+	Frame_Shift_Del	DEL	A	A	-	rs148484482		TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	14591343-b381-43d0-aea0-0e02221c09c6	g.chr19:55324675delA	ENST00000396284.2	+	6	796	c.796delA	c.(796-798)aafs	p.K268fs	KIR2DL4_ENST00000357494.4_Intron|KIR2DL4_ENST00000396293.1_Intron|KIR2DL4_ENST00000359085.4_Frame_Shift_Del_p.K270fs|KIR2DL4_ENST00000346587.4_Intron|KIR2DL4_ENST00000463062.1_3'UTR|KIR3DL1_ENST00000541392.1_Intron|KIR3DL1_ENST00000538269.1_Intron|KIR2DL4_ENST00000345540.5_Intron|KIR3DL1_ENST00000402254.2_Intron					killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 4									p.M271fs*>3(1)		NS(1)|breast(2)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|liver(2)|lung(2)|ovary(2)|prostate(3)|skin(1)	17				GBM - Glioblastoma multiforme(193;0.0192)		CTGGTGCTCCAAAAAAAAAGT	0.532													7	171	---	---	---	---					
EYA2	2139	broad.mit.edu	37	20	45771755	45771757	+	In_Frame_Del	DEL	GCA	GCA	-			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	14591343-b381-43d0-aea0-0e02221c09c6	g.chr20:45771755_45771757delGCA	ENST00000327619.5	+	10	1320_1322	c.946_948delGCA	c.(946-948)del	p.A316del	EYA2_ENST00000317304.6_Intron|EYA2_ENST00000357410.3_In_Frame_Del_p.A316del	NM_005244.4	NP_005235.3	O00167	EYA2_HUMAN	eyes absent homolog 2 (Drosophila)	316					DNA repair|histone dephosphorylation|mesodermal cell fate specification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	magnesium ion binding|protein binding|protein tyrosine phosphatase activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(7)|lung(11)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	32		Myeloproliferative disorder(115;0.0241)				CTTCAACCTTGCAGATACACATC	0.468													24	157	---	---	---	---					
ERG	2078	broad.mit.edu	37	21	39755553	39755554	+	Frame_Shift_Ins	INS	-	-	G			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	14591343-b381-43d0-aea0-0e02221c09c6	g.chr21:39755553_39755554insG	ENST00000442448.1	-	11	1431_1432	c.1160_1161insC	c.(1159-1161)cgafs	p.R387fs	ERG_ENST00000398897.1_Frame_Shift_Ins_p.R288fs|ERG_ENST00000453032.2_Frame_Shift_Ins_p.R312fs|ERG_ENST00000288319.7_Frame_Shift_Ins_p.R404fs|ERG_ENST00000398905.1_Frame_Shift_Ins_p.R380fs|ERG_ENST00000398919.2_Frame_Shift_Ins_p.R411fs|ERG_ENST00000398910.1_Frame_Shift_Ins_p.R388fs|ERG_ENST00000398911.1_Frame_Shift_Ins_p.R387fs|ERG_ENST00000398907.1_Frame_Shift_Ins_p.R381fs|ERG_ENST00000417133.2_Frame_Shift_Ins_p.R411fs	NM_004449.4	NP_004440.1	P11308	ERG_HUMAN	v-ets avian erythroblastosis virus E26 oncogene homolog	411					cell proliferation|multicellular organismal development|protein phosphorylation	cytoplasm|nucleus|ribonucleoprotein complex	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|signal transducer activity		EWSR1/ERG(178)|NDRG1/ERG(5)|TMPRSS2/ERG(3582)|FUS/ERG(167)|SLC45A3/ERG(50)	lung(2)|ovary(1)|skin(1)	4		Prostate(19;3.6e-06)				GAGATGACTCCGGGGGGTGGGG	0.589			T	"""EWSR1, TMPRSS2, ELF4, FUS, HERPUD1, NDRG1"""	"""Ewing sarcoma, prostate, AML"""								7	179	---	---	---	---					
DGKK	139189	broad.mit.edu	37	X	50165268	50165269	+	RNA	INS	-	-	T			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	14591343-b381-43d0-aea0-0e02221c09c6	g.chrX:50165268_50165269insT	ENST00000376025.2	-	0	897							Q5KSL6	DGKK_HUMAN	diacylglycerol kinase, kappa						activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|diacylglycerol metabolic process|intracellular signal transduction|platelet activation|response to oxidative stress	cytoplasm|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			central_nervous_system(1)|endometrium(12)|kidney(4)|large_intestine(5)|lung(18)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	45	Ovarian(276;0.236)					AAGACCATCACTTTTTTTCTTC	0.381													2	4	---	---	---	---					
FRMPD3	84443	broad.mit.edu	37	X	106845402	106845403	+	Frame_Shift_Ins	INS	-	-	G			TCGA-A3-3383-01A-01W-0886-08	TCGA-A3-3383-11A-01W-0886-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0fbb49c4-1739-433f-ae39-d26e927afff8	14591343-b381-43d0-aea0-0e02221c09c6	g.chrX:106845402_106845403insG	ENST00000276185.4	+	16	4232_4233	c.4232_4233insG	c.(4231-4233)tggfs	p.W1411fs				Q5JV73	FRPD3_HUMAN	FERM and PDZ domain containing 3	1411						cytoskeleton				breast(3)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(16)|ovary(2)|urinary_tract(1)	28						ACGTGTGCCTCGGGGGGCGAGT	0.609													7	261	---	---	---	---